Tune H. Pers, Juha M. Karjalainen, Yingleong Chan, Harm-Jan Westra, Andrew R. Wood, Jian Yang, Julian C. Lui, Sailaja Svedantam, Stefan Gustafsson, Tonu Esko, Tim Frayling, Elizabeth K. Speliotes, Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Michael Boehnke, Soumya Raychaudhuri, Rudolf S.N. Fehrmann, Joel N. Hirschhorn* and Lude Franke*
The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.