Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | p53_full_useme_maxed_cs.gct |
| Phenotype | WT |
| GeneSet | s2.symbols.gmt#p53_signalling |
| Enrichment Score (ES) | 0.34070346 |
| Normalized Enrichment Score (NES) | 1.4658169 |
| Nominal p-value | 0.028037382 |
| FDR q-value | 0.6143147 |
| FWER p-Value | 0.994 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RES | CORE_ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CDKN1A | CDKN1A StanfordSource, GeneCards | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0 | 0.843 | 0.0598 | Yes |
| 2 | BAX | BAX StanfordSource, GeneCards | BCL2-associated X protein | 1 | 0.823 | 0.1182 | Yes |
| 3 | MDM2 | MDM2 StanfordSource, GeneCards | Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) | 2 | 0.631 | 0.1629 | Yes |
| 4 | BCL2 | BCL2 StanfordSource, GeneCards | B-cell CLL/lymphoma 2 | 71 | 0.420 | 0.1859 | Yes |
| 5 | PML | PML StanfordSource, GeneCards | promyelocytic leukemia | 73 | 0.420 | 0.2156 | Yes |
| 6 | BBC3 | BBC3 StanfordSource, GeneCards | BCL2 binding component 3 | 79 | 0.416 | 0.2446 | Yes |
| 7 | TNF | TNF StanfordSource, GeneCards | tumor necrosis factor (TNF superfamily, member 2) | 264 | 0.340 | 0.2503 | Yes |
| 8 | TP53AP1 | TP53AP1 StanfordSource, GeneCards | TP53 activated protein 1 | 285 | 0.335 | 0.2721 | Yes |
| 9 | MAP2K7 | MAP2K7 StanfordSource, GeneCards | mitogen-activated protein kinase kinase 7 | 465 | 0.304 | 0.2758 | Yes |
| 10 | ACTA1 | ACTA1 StanfordSource, GeneCards | actin, alpha 1, skeletal muscle | 622 | 0.281 | 0.2802 | Yes |
| 11 | ESR1 | ESR1 StanfordSource, GeneCards | estrogen receptor 1 | 729 | 0.267 | 0.2885 | Yes |
| 12 | GAPD | GAPD StanfordSource, GeneCards | glyceraldehyde-3-phosphate dehydrogenase | 823 | 0.257 | 0.2975 | Yes |
| 13 | NDRG4 | NDRG4 StanfordSource, GeneCards | NDRG family member 4 | 851 | 0.253 | 0.3127 | Yes |
| 14 | WT1 | WT1 StanfordSource, GeneCards | Wilms tumor 1 | 961 | 0.244 | 0.3191 | Yes |
| 15 | BRAP | BRAP StanfordSource, GeneCards | BRCA1 associated protein | 1067 | 0.235 | 0.3253 | Yes |
| 16 | ATR | ATR StanfordSource, GeneCards | ataxia telangiectasia and Rad3 related | 1182 | 0.227 | 0.3301 | Yes |
| 17 | MAPK8IP2 | MAPK8IP2 StanfordSource, GeneCards | mitogen-activated protein kinase 8 interacting protein 2 | 1236 | 0.224 | 0.3407 | Yes |
| 18 | PPIA | PPIA StanfordSource, GeneCards | peptidylprolyl isomerase A (cyclophilin A) | 1881 | 0.182 | 0.2893 | No |
| 19 | TNFRSF10B | TNFRSF10B StanfordSource, GeneCards | tumor necrosis factor receptor superfamily, member 10b | 2660 | 0.138 | 0.2214 | No |
| 20 | RPL13A | RPL13A StanfordSource, GeneCards | ribosomal protein L13a | 2766 | 0.132 | 0.2203 | No |
| 21 | TNFAIP1 | TNFAIP1 StanfordSource, GeneCards | tumor necrosis factor, alpha-induced protein 1 (endothelial) | 2877 | 0.127 | 0.2183 | No |
| 22 | TP53BP2 | TP53BP2 StanfordSource, GeneCards | tumor protein p53 binding protein, 2 | 3118 | 0.116 | 0.2025 | No |
| 23 | STAT5A | STAT5A StanfordSource, GeneCards | signal transducer and activator of transcription 5A | 3259 | 0.109 | 0.1963 | No |
| 24 | ABCB1 | ABCB1 StanfordSource, GeneCards | ATP-binding cassette, sub-family B (MDR/TAP), member 1 | 3353 | 0.105 | 0.1944 | No |
| 25 | TRAF4 | TRAF4 StanfordSource, GeneCards | TNF receptor-associated factor 4 | 3355 | 0.105 | 0.2017 | No |
| 26 | PMAIP1 | PMAIP1 StanfordSource, GeneCards | phorbol-12-myristate-13-acetate-induced protein 1 | 3490 | 0.098 | 0.1953 | No |
| 27 | PCAF | PCAF StanfordSource, GeneCards | p300/CBP-associated factor | 3512 | 0.097 | 0.2001 | No |
| 28 | APEX1 | APEX1 StanfordSource, GeneCards | APEX nuclease (multifunctional DNA repair enzyme) 1 | 3738 | 0.086 | 0.1838 | No |
| 29 | RB1 | RB1 StanfordSource, GeneCards | retinoblastoma 1 (including osteosarcoma) | 3854 | 0.081 | 0.1780 | No |
| 30 | PRKCQ | PRKCQ StanfordSource, GeneCards | protein kinase C, theta | 3861 | 0.081 | 0.1832 | No |
| 31 | TTRAP | TTRAP StanfordSource, GeneCards | TRAF and TNF receptor associated protein | 4198 | 0.065 | 0.1542 | No |
| 32 | MAP2K4 | MAP2K4 StanfordSource, GeneCards | mitogen-activated protein kinase kinase 4 | 4310 | 0.060 | 0.1474 | No |
| 33 | CREBBP | CREBBP StanfordSource, GeneCards | CREB binding protein (Rubinstein-Taybi syndrome) | 4356 | 0.059 | 0.1471 | No |
| 34 | HSPA4 | HSPA4 StanfordSource, GeneCards | heat shock 70kDa protein 4 | 5076 | 0.027 | 0.0772 | No |
| 35 | PRKCA | PRKCA StanfordSource, GeneCards | protein kinase C, alpha | 5086 | 0.027 | 0.0782 | No |
| 36 | BAI1 | BAI1 StanfordSource, GeneCards | brain-specific angiogenesis inhibitor 1 | 5113 | 0.026 | 0.0775 | No |
| 37 | MYC | MYC StanfordSource, GeneCards | v-myc myelocytomatosis viral oncogene homolog (avian) | 5372 | 0.015 | 0.0528 | No |
| 38 | GTSE1 | GTSE1 StanfordSource, GeneCards | G-2 and S-phase expressed 1 | 5486 | 0.010 | 0.0422 | No |
| 39 | NFKB1 | NFKB1 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 5616 | 0.004 | 0.0296 | No |
| 40 | HIPK2 | HIPK2 StanfordSource, GeneCards | homeodomain interacting protein kinase 2 | 5668 | 0.002 | 0.0247 | No |
| 41 | APAF1 | APAF1 StanfordSource, GeneCards | apoptotic protease activating factor | 5864 | -0.007 | 0.0057 | No |
| 42 | CSNK2A2 | CSNK2A2 StanfordSource, GeneCards | casein kinase 2, alpha prime polypeptide | 5876 | -0.007 | 0.0051 | No |
| 43 | WRN | WRN StanfordSource, GeneCards | Werner syndrome | 5973 | -0.011 | -0.0036 | No |
| 44 | BZRP | BZRP StanfordSource, GeneCards | benzodiazapine receptor (peripheral) | 6059 | -0.016 | -0.0110 | No |
| 45 | NDRG1 | NDRG1 StanfordSource, GeneCards | N-myc downstream regulated gene 1 | 6229 | -0.024 | -0.0262 | No |
| 46 | TNFSF6 | TNFSF6 StanfordSource, GeneCards | tumor necrosis factor (ligand) superfamily, member 6 | 6238 | -0.024 | -0.0252 | No |
| 47 | HIF1A | HIF1A StanfordSource, GeneCards | hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 6266 | -0.026 | -0.0261 | No |
| 48 | BRCA1 | BRCA1 StanfordSource, GeneCards | breast cancer 1, early onset | 6297 | -0.027 | -0.0272 | No |
| 49 | PRKCB1 | PRKCB1 StanfordSource, GeneCards | protein kinase C, beta 1 | 6340 | -0.029 | -0.0293 | No |
| 50 | E2F1 | E2F1 StanfordSource, GeneCards | E2F transcription factor 1 | 6448 | -0.034 | -0.0375 | No |
| 51 | THRA | THRA StanfordSource, GeneCards | thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian) | 6629 | -0.042 | -0.0525 | No |
| 52 | TP53 | TP53 StanfordSource, GeneCards | tumor protein p53 (Li-Fraumeni syndrome) | 6783 | -0.050 | -0.0642 | No |
| 53 | PRKDC | PRKDC StanfordSource, GeneCards | protein kinase, DNA-activated, catalytic polypeptide | 6840 | -0.054 | -0.0660 | No |
| 54 | BAP1 | BAP1 StanfordSource, GeneCards | BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) | 7179 | -0.070 | -0.0948 | No |
| 55 | PRKCG | PRKCG StanfordSource, GeneCards | protein kinase C, gamma | 7186 | -0.071 | -0.0904 | No |
| 56 | TEAD1 | TEAD1 StanfordSource, GeneCards | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 7300 | -0.076 | -0.0963 | No |
| 57 | CHEK2 | CHEK2 StanfordSource, GeneCards | CHK2 checkpoint homolog (S. pombe) | 7442 | -0.084 | -0.1044 | No |
| 58 | RASA1 | RASA1 StanfordSource, GeneCards | RAS p21 protein activator (GTPase activating protein) 1 | 7533 | -0.089 | -0.1071 | No |
| 59 | CDK7 | CDK7 StanfordSource, GeneCards | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 7615 | -0.093 | -0.1086 | No |
| 60 | ATM | ATM StanfordSource, GeneCards | ataxia telangiectasia mutated (includes complementation groups A, C and D) | 7735 | -0.100 | -0.1134 | No |
| 61 | SP1 | SP1 StanfordSource, GeneCards | Sp1 transcription factor | 7738 | -0.100 | -0.1065 | No |
| 62 | THBS1 | THBS1 StanfordSource, GeneCards | thrombospondin 1 | 7849 | -0.106 | -0.1099 | No |
| 63 | CTSD | CTSD StanfordSource, GeneCards | cathepsin D (lysosomal aspartyl protease) | 7985 | -0.113 | -0.1153 | No |
| 64 | ACTB | ACTB StanfordSource, GeneCards | actin, beta | 7993 | -0.114 | -0.1080 | No |
| 65 | CSNK2A1 | CSNK2A1 StanfordSource, GeneCards | casein kinase 2, alpha 1 polypeptide | 8167 | -0.125 | -0.1164 | No |
| 66 | MAP4 | MAP4 StanfordSource, GeneCards | microtubule-associated protein 4 | 8194 | -0.128 | -0.1099 | No |
| 67 | CSNK1A1 | CSNK1A1 StanfordSource, GeneCards | casein kinase 1, alpha 1 | 8207 | -0.128 | -0.1020 | No |
| 68 | TRAF1 | TRAF1 StanfordSource, GeneCards | TNF receptor-associated factor 1 | 8266 | -0.133 | -0.0984 | No |
| 69 | FADD | FADD StanfordSource, GeneCards | Fas (TNFRSF6)-associated via death domain | 8327 | -0.137 | -0.0947 | No |
| 70 | PMP22 | PMP22 StanfordSource, GeneCards | peripheral myelin protein 22 | 8345 | -0.138 | -0.0866 | No |
| 71 | DAXX | DAXX StanfordSource, GeneCards | death-associated protein 6 | 8486 | -0.148 | -0.0901 | No |
| 72 | GADD45A | GADD45A StanfordSource, GeneCards | growth arrest and DNA-damage-inducible, alpha | 8507 | -0.149 | -0.0815 | No |
| 73 | CASP9 | CASP9 StanfordSource, GeneCards | caspase 9, apoptosis-related cysteine protease | 8578 | -0.154 | -0.0776 | No |
| 74 | CDC2 | CDC2 StanfordSource, GeneCards | cell division cycle 2, G1 to S and G2 to M | 8582 | -0.154 | -0.0670 | No |
| 75 | CSNK2B | CSNK2B StanfordSource, GeneCards | casein kinase 2, beta polypeptide | 8855 | -0.173 | -0.0819 | No |
| 76 | TRAF5 | TRAF5 StanfordSource, GeneCards | TNF receptor-associated factor 5 | 8880 | -0.175 | -0.0719 | No |
| 77 | TP73L | TP73L StanfordSource, GeneCards | tumor protein p73-like | 8978 | -0.183 | -0.0685 | No |
| 78 | TBP | TBP StanfordSource, GeneCards | TATA box binding protein | 9007 | -0.185 | -0.0582 | No |
| 79 | NUMB | NUMB StanfordSource, GeneCards | numb homolog (Drosophila) | 9019 | -0.187 | -0.0461 | No |
| 80 | SFN | SFN StanfordSource, GeneCards | stratifin | 9070 | -0.190 | -0.0376 | No |
| 81 | SERPINB5 | SERPINB5 StanfordSource, GeneCards | serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5 | 9232 | -0.203 | -0.0392 | No |
| 82 | EI24 | EI24 StanfordSource, GeneCards | etoposide induced 2.4 mRNA | 9475 | -0.231 | -0.0470 | No |
| 83 | CCNH | CCNH StanfordSource, GeneCards | cyclin H | 9565 | -0.244 | -0.0386 | No |
| 84 | CHEK1 | CHEK1 StanfordSource, GeneCards | CHK1 checkpoint homolog (S. pombe) | 9845 | -0.299 | -0.0452 | No |
| 85 | RELA | RELA StanfordSource, GeneCards | v-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65 (avian) | 9904 | -0.317 | -0.0285 | No |
| 86 | CDKN2A | CDKN2A StanfordSource, GeneCards | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) | 9931 | -0.324 | -0.0081 | No |
| 87 | EP300 | EP300 StanfordSource, GeneCards | E1A binding protein p300 | 9993 | -0.349 | 0.0106 | No |
