Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | p53_full_useme_maxed_cs.gct |
| Phenotype | MUT |
| GeneSet | s2.symbols.gmt#igf1Pathway |
| Enrichment Score (ES) | -0.55741864 |
| Normalized Enrichment Score (NES) | -1.815263 |
| Nominal p-value | 0.0 |
| FDR q-value | 0.20555986 |
| FWER p-Value | 0.325 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RES | CORE_ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAPK3 | MAPK3 StanfordSource, GeneCards | mitogen-activated protein kinase 3 | 2905 | 0.125 | -0.2413 | No |
| 2 | IGF1R | IGF1R StanfordSource, GeneCards | insulin-like growth factor 1 receptor | 3110 | 0.116 | -0.2180 | No |
| 3 | PIK3R1 | PIK3R1 StanfordSource, GeneCards | phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha) | 3882 | 0.080 | -0.2646 | No |
| 4 | GRB2 | GRB2 StanfordSource, GeneCards | growth factor receptor-bound protein 2 | 4102 | 0.070 | -0.2602 | No |
| 5 | PTPN11 | PTPN11 StanfordSource, GeneCards | protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1) | 4511 | 0.053 | -0.2810 | No |
| 6 | JUN | JUN StanfordSource, GeneCards | v-jun sarcoma virus 17 oncogene homolog (avian) | 5283 | 0.019 | -0.3502 | No |
| 7 | SHC1 | SHC1 StanfordSource, GeneCards | SHC (Src homology 2 domain containing) transforming protein 1 | 6401 | -0.032 | -0.4491 | No |
| 8 | IRS1 | IRS1 StanfordSource, GeneCards | insulin receptor substrate 1 | 7494 | -0.087 | -0.5247 | Yes |
| 9 | RASA1 | RASA1 StanfordSource, GeneCards | RAS p21 protein activator (GTPase activating protein) 1 | 7533 | -0.089 | -0.4952 | Yes |
| 10 | HRAS | HRAS StanfordSource, GeneCards | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | 7563 | -0.090 | -0.4642 | Yes |
| 11 | SRF | SRF StanfordSource, GeneCards | serum response factor (c-fos serum response element-binding transcription factor) | 7906 | -0.109 | -0.4572 | Yes |
| 12 | MAPK8 | MAPK8 StanfordSource, GeneCards | mitogen-activated protein kinase 8 | 7956 | -0.112 | -0.4202 | Yes |
| 13 | SOS1 | SOS1 StanfordSource, GeneCards | son of sevenless homolog 1 (Drosophila) | 8043 | -0.116 | -0.3851 | Yes |
| 14 | CSNK2A1 | CSNK2A1 StanfordSource, GeneCards | casein kinase 2, alpha 1 polypeptide | 8167 | -0.125 | -0.3505 | Yes |
| 15 | IGF1 | IGF1 StanfordSource, GeneCards | insulin-like growth factor 1 (somatomedin C) | 8346 | -0.138 | -0.3165 | Yes |
| 16 | FOS | FOS StanfordSource, GeneCards | v-fos FBJ murine osteosarcoma viral oncogene homolog | 8716 | -0.163 | -0.2921 | Yes |
| 17 | RAF1 | RAF1 StanfordSource, GeneCards | v-raf-1 murine leukemia viral oncogene homolog 1 | 8728 | -0.164 | -0.2318 | Yes |
| 18 | ELK1 | ELK1 StanfordSource, GeneCards | ELK1, member of ETS oncogene family | 9250 | -0.205 | -0.2067 | Yes |
| 19 | PIK3CA | PIK3CA StanfordSource, GeneCards | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 10023 | -0.366 | -0.1461 | Yes |
| 20 | MAP2K1 | MAP2K1 StanfordSource, GeneCards | mitogen-activated protein kinase kinase 1 | 10067 | -0.410 | 0.0032 | Yes |
