Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | Gender_collapsed.gct |
| Phenotype | MALE |
| GeneSet | C2.symbols.gmt#ST_T_Cell_Signal_Transduction |
| Enrichment Score (ES) | 0.33428615 |
| Normalized Enrichment Score (NES) | 1.2139854 |
| Nominal p-value | 0.19723183 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.974 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RES | CORE_ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | SOS2 | SOS2 StanfordSource, GeneCards | son of sevenless homolog 2 (Drosophila) | 170 | 0.420 | 0.0549 | Yes |
| 2 | LCP2 | LCP2 StanfordSource, GeneCards | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 402 | 0.355 | 0.0954 | Yes |
| 3 | PAK4 | PAK4 StanfordSource, GeneCards | p21(CDKN1A)-activated kinase 4 | 494 | 0.337 | 0.1425 | Yes |
| 4 | ZAP70 | ZAP70 StanfordSource, GeneCards | zeta-chain (TCR) associated protein kinase 70kDa | 579 | 0.323 | 0.1878 | Yes |
| 5 | NFKB2 | NFKB2 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 815 | 0.293 | 0.2183 | Yes |
| 6 | RASGRP1 | RASGRP1 StanfordSource, GeneCards | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 1194 | 0.256 | 0.2334 | Yes |
| 7 | NFKBIB | NFKBIB StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 1243 | 0.251 | 0.2698 | Yes |
| 8 | RASGRP2 | RASGRP2 StanfordSource, GeneCards | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 1334 | 0.244 | 0.3024 | Yes |
| 9 | LAT | LAT StanfordSource, GeneCards | linker for activation of T cells | 1520 | 0.232 | 0.3266 | Yes |
| 10 | GRAP2 | GRAP2 StanfordSource, GeneCards | GRB2-related adaptor protein 2 | 2185 | 0.195 | 0.3131 | Yes |
| 11 | PAK6 | PAK6 StanfordSource, GeneCards | p21(CDKN1A)-activated kinase 6 | 2314 | 0.189 | 0.3343 | Yes |
| 12 | NFKBIE | NFKBIE StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 3433 | 0.140 | 0.2819 | No |
| 13 | LCK | LCK StanfordSource, GeneCards | lymphocyte-specific protein tyrosine kinase | 3439 | 0.140 | 0.3037 | No |
| 14 | PAK3 | PAK3 StanfordSource, GeneCards | p21 (CDKN1A)-activated kinase 3 | 5503 | 0.069 | 0.1772 | No |
| 15 | PLCG1 | PLCG1 StanfordSource, GeneCards | phospholipase C, gamma 1 (formerly subtype 148) | 5548 | 0.068 | 0.1849 | No |
| 16 | NFKBIL1 | NFKBIL1 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 5639 | 0.065 | 0.1891 | No |
| 17 | NFKBIA | NFKBIA StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 5710 | 0.063 | 0.1944 | No |
| 18 | CD28 | CD28 StanfordSource, GeneCards | CD28 antigen (Tp44) | 6841 | 0.031 | 0.1239 | No |
| 19 | CD3D | CD3D StanfordSource, GeneCards | CD3D antigen, delta polypeptide (TiT3 complex) | 6910 | 0.029 | 0.1239 | No |
| 20 | NFAT5 | NFAT5 StanfordSource, GeneCards | nuclear factor of activated T-cells 5, tonicity-responsive | 7944 | -0.003 | 0.0555 | No |
| 21 | CBL | CBL StanfordSource, GeneCards | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 8201 | -0.009 | 0.0399 | No |
| 22 | PAK7 | PAK7 StanfordSource, GeneCards | p21(CDKN1A)-activated kinase 7 | 8225 | -0.010 | 0.0399 | No |
| 23 | FBXW7 | FBXW7 StanfordSource, GeneCards | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) | 8520 | -0.018 | 0.0232 | No |
| 24 | ITK | ITK StanfordSource, GeneCards | IL2-inducible T-cell kinase | 9007 | -0.031 | -0.0043 | No |
| 25 | PAK1 | PAK1 StanfordSource, GeneCards | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 9468 | -0.045 | -0.0279 | No |
| 26 | RASGRP3 | RASGRP3 StanfordSource, GeneCards | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | 9798 | -0.054 | -0.0412 | No |
| 27 | DAG1 | DAG1 StanfordSource, GeneCards | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 9820 | -0.055 | -0.0339 | No |
| 28 | MAPK1 | MAPK1 StanfordSource, GeneCards | mitogen-activated protein kinase 1 | 10319 | -0.071 | -0.0559 | No |
| 29 | VAV1 | VAV1 StanfordSource, GeneCards | vav 1 oncogene | 10476 | -0.076 | -0.0543 | No |
| 30 | EPHB2 | EPHB2 StanfordSource, GeneCards | EphB2 | 10656 | -0.082 | -0.0533 | No |
| 31 | PAK2 | PAK2 StanfordSource, GeneCards | p21 (CDKN1A)-activated kinase 2 | 11832 | -0.123 | -0.1122 | No |
| 32 | CSK | CSK StanfordSource, GeneCards | c-src tyrosine kinase | 11838 | -0.123 | -0.0932 | No |
| 33 | SOS1 | SOS1 StanfordSource, GeneCards | son of sevenless homolog 1 (Drosophila) | 11971 | -0.128 | -0.0818 | No |
| 34 | DTYMK | DTYMK StanfordSource, GeneCards | deoxythymidylate kinase (thymidylate kinase) | 11996 | -0.129 | -0.0630 | No |
| 35 | ITPKB | ITPKB StanfordSource, GeneCards | inositol 1,4,5-trisphosphate 3-kinase B | 12205 | -0.138 | -0.0552 | No |
| 36 | ITPKA | ITPKA StanfordSource, GeneCards | inositol 1,4,5-trisphosphate 3-kinase A | 12468 | -0.148 | -0.0493 | No |
| 37 | RAF1 | RAF1 StanfordSource, GeneCards | v-raf-1 murine leukemia viral oncogene homolog 1 | 12554 | -0.152 | -0.0309 | No |
| 38 | CTLA4 | CTLA4 StanfordSource, GeneCards | cytotoxic T-lymphocyte-associated protein 4 | 12644 | -0.156 | -0.0123 | No |
| 39 | NFKB1 | NFKB1 StanfordSource, GeneCards | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 13726 | -0.215 | -0.0504 | No |
| 40 | NCK1 | NCK1 StanfordSource, GeneCards | NCK adaptor protein 1 | 14507 | -0.290 | -0.0567 | No |
| 41 | GRB2 | GRB2 StanfordSource, GeneCards | growth factor receptor-bound protein 2 | 14519 | -0.291 | -0.0115 | No |
| 42 | PTPRC | PTPRC StanfordSource, GeneCards | protein tyrosine phosphatase, receptor type, C | 14573 | -0.299 | 0.0321 | No |
