# gene_set_details

systematic_name: M8317
exact_source: GO:0016893
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016893
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:mah]


systematic_name: M17986
exact_source: GO:0016894
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016894
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:mah]


systematic_name: M43190
exact_source: GO:0016896
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016896
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. [GOC:ai]


systematic_name: M9511
exact_source: GO:0016903
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016903
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M26455
exact_source: GO:0016907
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016907
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah]


systematic_name: M18726
exact_source: GO:0016917
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016917
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms. [GOC:jl, GOC:signaling, PMID:10637650]


systematic_name: M18525
exact_source: GO:0016918
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016918
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina. [ISBN:0198506732]


systematic_name: M26456
exact_source: GO:0016922
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016922
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nuclear receptor protein. Nuclear receptor proteins are DNA-binding transcription factors which are regulated by binding to a ligand. [PMID:7776974]


systematic_name: M26457
exact_source: GO:0016929
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016929
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An thiol-dependent isopeptidase activity that cleaves SUMO from a target protein to which it is conjugated. [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250, PMID:23746258]


systematic_name: M48627
exact_source: GO:0016937
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016937
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a short-chain 2,3-saturated fatty acyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = a short-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons. [RHEA:47196]


systematic_name: M26459
exact_source: GO:0017002
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017002
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta. [GOC:mah, GOC:signaling, ISBN:0198506732]


systematic_name: M43191
exact_source: GO:0017017
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017017
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate. [GOC:mah, PMID:12184814]


systematic_name: M18958
exact_source: GO:0017022
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017022
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a myosin; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments. [GOC:mah]


systematic_name: M19065
exact_source: GO:0017025
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017025
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]


systematic_name: M18343
exact_source: GO:0017056
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017056
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules. [GOC:mah, PMID:25802992]


systematic_name: M46002
exact_source: GO:0017076
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017076
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. [GOC:ai]


systematic_name: M43192
exact_source: GO:0017077
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017077
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis. [PMID:15738989, PMID:16179945]


systematic_name: M34411
exact_source: GO:0017083
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017083
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,3)]-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.152, RHEA:14257]


systematic_name: M18148
exact_source: GO:0017110
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017110
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleoside monophosphate + phosphate. [EC:3.6.1.6]


systematic_name: M29470
exact_source: GO:0017116
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017116
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix. [GOC:jl]


systematic_name: M7113
exact_source: GO:0017124
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017124
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]


systematic_name: M26463
exact_source: GO:0017128
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017128
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. [GOC:cjm, PMID:20043909, PMID:20302864]


systematic_name: M45358
exact_source: GO:0017136
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017136
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone. [PMID:28450737]


systematic_name: M26466
exact_source: GO:0017154
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017154
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:15239958]


systematic_name: M26468
exact_source: GO:0017166
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017166
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane. [ISBN:0721662544]


systematic_name: M4452
exact_source: GO:0017171
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0017171
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase]


systematic_name: M34412
exact_source: GO:0018685
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0018685
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O. [EC:1.14.15.3]


systematic_name: M29472
exact_source: GO:0019103
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019103
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a pyrimidine nucleotide, a pyrimidine nucleoside esterified with (ortho)phosphate. [GOC:ai]


systematic_name: M18043
exact_source: GO:0019104
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019104
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site. [GOC:elh, PMID:11554296]


systematic_name: M43194
exact_source: GO:0019136
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019136
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate. [EC:2.7.1.145]


systematic_name: M18781
exact_source: GO:0019198
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019198
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. [GOC:hjd]


systematic_name: M14378
exact_source: GO:0019199
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019199
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:mah]


systematic_name: M18440
exact_source: GO:0019200
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019200
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule. [GOC:jl]


systematic_name: M19155
exact_source: GO:0019205
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019205
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate. [GOC:jl]


systematic_name: M7387
exact_source: GO:0019207
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019207
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]


systematic_name: M19186
exact_source: GO:0019208
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019208
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule. [GOC:ai]


systematic_name: M12088
exact_source: GO:0019209
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019209
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [GOC:ai]


systematic_name: M18545
exact_source: GO:0019215
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019215
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. [ISBN:0198506732]


systematic_name: M26472
exact_source: GO:0019237
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019237
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis. [GOC:jl, SO:0000577]


systematic_name: M26473
exact_source: GO:0019238
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019238
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring. [GOC:mah]


systematic_name: M19047
exact_source: GO:0019239
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019239
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH3/NH2R). [GOC:jl]


systematic_name: M26474
exact_source: GO:0019531
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019531
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals. [ISBN:0198506732]


systematic_name: M26475
exact_source: GO:0019534
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019534
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. [ISBN:0198506732]


systematic_name: M26476
exact_source: GO:0019763
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019763
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:signaling, ISBN:0198547684]


systematic_name: M48628
exact_source: GO:0019770
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019770
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


systematic_name: M19020
exact_source: GO:0019783
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019783
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An isopeptidase activity that cleaves ubiquitin or ubiquitin-like proteins (ULP; e.g. ATG8, ISG15, NEDD8, SUMO) from target proteins. [PMID:19489724]


systematic_name: M26477
exact_source: GO:0019784
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019784
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An isopeptidase activity that cleaves NEDD8 from a target protein to which it is conjugated. [GOC:mah, PMID:25628956]


systematic_name: M26478
exact_source: GO:0019788
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019788
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y = Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages. [GOC:mah]


systematic_name: M18557
exact_source: GO:0019789
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019789
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y = Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages. [GOC:rn, PMID:11031248, PMID:11265250]


systematic_name: M26479
exact_source: GO:0019798
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019798
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2. [GOC:mah, PMID:4371784]


systematic_name: M43195
exact_source: GO:0019826
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019826
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2). [GOC:mah]


systematic_name: M43196
exact_source: GO:0019829
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019829
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:ai]


systematic_name: M6854
exact_source: GO:0019838
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019838
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate. [GOC:curators]


systematic_name: M18637
exact_source: GO:0019840
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019840
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. [GOC:jl]


systematic_name: M18925
exact_source: GO:0019841
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019841
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation. [GOC:curators]


systematic_name: M18676
exact_source: GO:0019842
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019842
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. [GOC:ai]


systematic_name: M18710
exact_source: GO:0019894
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019894
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation. [GOC:curators, PMID:8606779]


systematic_name: M17960
exact_source: GO:0019905
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019905
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse. [ISBN:0198506732]


systematic_name: M26486
exact_source: GO:0019911
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019911
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve. [GOC:mah]


systematic_name: M18255
exact_source: GO:0019955
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019955
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity. [GOC:ai, GOC:bf, ISBN:0198599471]


systematic_name: M18707
exact_source: GO:0019956
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019956
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:ai, GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]


systematic_name: M26487
exact_source: GO:0019957
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019957
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]


systematic_name: M26488
exact_source: GO:0019958
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019958
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:ai]


systematic_name: M26489
exact_source: GO:0019960
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0019960
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif. [GOC:ai]


systematic_name: M18151
exact_source: GO:0022803
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022803
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18537
exact_source: GO:0022804
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022804
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M46980
exact_source: GO:0022810
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022810
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26491
exact_source: GO:0022821
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022821
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18665
exact_source: GO:0022829
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022829
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M43198
exact_source: GO:0022832
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022832
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M46981
exact_source: GO:0022834
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022834
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18082
exact_source: GO:0022836
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022836
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus. [GOC:mtg_transport]


systematic_name: M48629
exact_source: GO:0022839
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022839
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus. [GOC:mtg_transport]


systematic_name: M26492
exact_source: GO:0022841
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022841
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M17932
exact_source: GO:0022842
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022842
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M17981
exact_source: GO:0022843
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022843
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26493
exact_source: GO:0022848
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022848
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine. [GOC:mah, PMID:2466967]


systematic_name: M26494
exact_source: GO:0022849
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022849
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26495
exact_source: GO:0022850
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022850
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, PMID:12867984]


systematic_name: M17881
exact_source: GO:0022853
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022853
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26497
exact_source: GO:0022858
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022858
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18872
exact_source: GO:0022884
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0022884
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a macromolecule from one side of a membrane to the other. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26500
exact_source: GO:0030020
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030020
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress. [GOC:mah, ISBN:0815316194]


systematic_name: M26501
exact_source: GO:0030021
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030021
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan. [GOC:mah, ISBN:0815316194]


systematic_name: M26502
exact_source: GO:0030023
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030023
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A component of the extracellular matrix that enables the matrix to recoil after transient stretching. [GOC:mah, ISBN:0815316194]


systematic_name: M18838
exact_source: GO:0030159
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030159
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that provides a physical support for the assembly of a multiprotein receptor signaling complex. [GOC:mah]


systematic_name: M6526
exact_source: GO:0030165
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030165
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595]


systematic_name: M18096
exact_source: GO:0030169
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030169
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm. [GOC:mah]


systematic_name: M18721
exact_source: GO:0030228
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030228
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids. [GOC:bf, GOC:mah, PMID:12827279]


systematic_name: M9636
exact_source: GO:0030246
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030246
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. [GOC:mah]


systematic_name: M19396
exact_source: GO:0030247
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030247
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. [GOC:mah]


systematic_name: M26507
exact_source: GO:0030274
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030274
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions. [GOC:go_curators, Pfam:PF00412]


systematic_name: M18189
exact_source: GO:0030276
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030276
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles. [GOC:jl, GOC:mah, ISBN:0198506732]


systematic_name: M26508
exact_source: GO:0030280
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030280
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure. [GOC:mah]


systematic_name: M29477
exact_source: GO:0030283
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030283
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+. [EC:1.1.1.51]


systematic_name: M18368
exact_source: GO:0030291
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030291
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a protein serine/threonine kinase. [GOC:mah]


systematic_name: M19229
exact_source: GO:0030296
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030296
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein. [GOC:ai, ISBN:0198506732]


systematic_name: M17994
exact_source: GO:0030332
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030332
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis. [GOC:ai]


systematic_name: M26514
exact_source: GO:0030368
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030368
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:jl, GOC:signaling]


systematic_name: M26515
exact_source: GO:0030374
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030374
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:dph, GOC:tb]


systematic_name: M26516
exact_source: GO:0030492
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030492
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin. [GOC:jl]


systematic_name: M18041
exact_source: GO:0030506
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030506
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732]


systematic_name: M18603
exact_source: GO:0030507
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030507
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers. [GOC:mah, ISBN:0198506732]


systematic_name: M34414
exact_source: GO:0030533
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030533
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis. [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]


systematic_name: M18452
exact_source: GO:0030551
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030551
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue. [GOC:ai]


systematic_name: M18960
exact_source: GO:0030594
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030594
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]


systematic_name: M19028
exact_source: GO:0030742
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030742
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein or protein complex when at least one of the interacting partners is in the GTP-bound state. [GOC:go_curators, GOC:krc]


systematic_name: M26526
exact_source: GO:0030911
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030911
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices. [GOC:mah]


systematic_name: M40654
exact_source: GO:0030943
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030943
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion. [GOC:mah]


systematic_name: M26527
exact_source: GO:0030957
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030957
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus. [GOC:mah, PMID:9094689]


systematic_name: M26529
exact_source: GO:0030976
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0030976
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. [GOC:mlg]


systematic_name: M18554
exact_source: GO:0031005
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031005
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain. [GOC:mah, PMID:11336782]


systematic_name: M17893
exact_source: GO:0031072
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031072
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a heat shock protein, a protein synthesized or activated in response to heat shock. [GOC:mah, GOC:vw]


systematic_name: M43199
exact_source: GO:0031210
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031210
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:mah, ISBN:0198506732]


systematic_name: M18612
exact_source: GO:0031369
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031369
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. [GOC:mah]


systematic_name: M18269
exact_source: GO:0031418
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031418
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species. [GOC:mah]


systematic_name: M26534
exact_source: GO:0031419
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031419
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. [GOC:mah]


systematic_name: M18586
exact_source: GO:0031420
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031420
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen. [GOC:mah]


systematic_name: M18819
exact_source: GO:0031432
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031432
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively. [GOC:mah, PMID:10481174]


systematic_name: M26535
exact_source: GO:0031433
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031433
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase. [GOC:mah, PMID:10481174]


systematic_name: M17903
exact_source: GO:0031434
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031434
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase. [GOC:mah]


systematic_name: M18906
exact_source: GO:0031435
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031435
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase. [GOC:bf]


systematic_name: M18842
exact_source: GO:0031489
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031489
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


systematic_name: M18054
exact_source: GO:0031491
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031491
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. [GOC:mah]


systematic_name: M26536
exact_source: GO:0031543
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031543
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2. [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462]


systematic_name: M26537
exact_source: GO:0031545
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031545
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2. [GOC:mah]


systematic_name: M26544
exact_source: GO:0031720
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031720
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex. [GOC:mah, ISBN:0198506732]


systematic_name: M26553
exact_source: GO:0031956
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031956
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a medium-chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate. A medium-chain fatty acid has an aliphatic tail containing 6 to 12 carbons. [RHEA:48340]


systematic_name: M26554
exact_source: GO:0031957
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0031957
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate. A very long-chain fatty acid has an aliphatic tail containing more than 22 carbons. [PMID:18024425, RHEA:54536]


systematic_name: M26566
exact_source: GO:0032190
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032190
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities. [GOC:mah, PMID:12398221]


systematic_name: M29483
exact_source: GO:0032217
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032217
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins. [GOC:rn, PMID:16204239]


systematic_name: M18687
exact_source: GO:0032266
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032266
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position. [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775]


systematic_name: M26568
exact_source: GO:0032393
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032393
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149]


systematic_name: M26569
exact_source: GO:0032394
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032394
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families. [GOC:add, GOC:signaling, ISBN:0781735149]


systematic_name: M18156
exact_source: GO:0032395
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032395
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


systematic_name: M43201
exact_source: GO:0032396
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032396
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte. [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134]


systematic_name: M26573
exact_source: GO:0032453
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032453
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein. [GOC:mah]


systematic_name: M26574
exact_source: GO:0032454
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032454
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. [PMID:16362057]


systematic_name: M48630
exact_source: GO:0032561
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032561
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety. [GOC:mah]


systematic_name: M18284
exact_source: GO:0032934
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032934
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. [GOC:mah]


systematic_name: M40656
exact_source: GO:0032977
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0032977
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds transmembrane domain-containing proteins and mediates their integration into a membrane. [PMID:14739936, PMID:29809151, PMID:30415835, PMID:32459176]


systematic_name: M18715
exact_source: GO:0033038
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033038
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste. [GOC:mah]


systematic_name: M26578
exact_source: GO:0033192
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033192
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin. [GOC:mah, PMID:15359118]


systematic_name: M18547
exact_source: GO:0033218
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033218
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. [GOC:mah]


systematic_name: M19149
exact_source: GO:0033293
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033293
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). [GOC:mah]


systematic_name: M29486
exact_source: GO:0033300
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033300
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of dehydroascorbate, 5-(1,2-dihydroxyethyl)furan-2,3,4(5H)-trione, from one side of a membrane to the other. [GOC:go_curators]


systematic_name: M18661
exact_source: GO:0033549
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033549
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate. [GOC:mah, PMID:12184814, PMID:17208316]


systematic_name: M17984
exact_source: GO:0033558
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033558
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: H2O + N6-acetyl-L-lysyl-[protein] = acetate + L-lysyl-[protein]. [PMID:27296530, RHEA:58108]


systematic_name: M26580
exact_source: GO:0033691
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033691
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sialic acid, a N- or O- substituted derivative of neuraminic acid, a nine carbon monosaccharide. Sialic acids often occur in polysaccharides, glycoproteins, and glycolipids in animals and bacteria. [GOC:add, ISBN:9780721601465]


systematic_name: M12203
exact_source: GO:0033764
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0033764
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP, and in which one substrate is a sterol derivative. [GOC:mah]


systematic_name: M29487
exact_source: GO:0034040
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034040
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). [GOC:BHF, GOC:rl]


systematic_name: M46984
exact_source: GO:0034056
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034056
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an estrogen response element (ERE), a conserved sequence found in the promoters of genes whose expression is regulated in response to estrogen. [GOC:ecd, PMID:15036253, PMID:17975005]


systematic_name: M12881
exact_source: GO:0034061
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034061
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. [EC:2.7.7.7, GOC:mah]


systematic_name: M18531
exact_source: GO:0034212
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034212
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the acetylation of an amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-acetylpeptide. [GOC:mah]


systematic_name: M26585
exact_source: GO:0034235
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034235
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a glycosylphosphatidylinositol anchor. GPI anchors serve to attach membrane proteins to the lipid bilayer of cell membranes. [GOC:vw]


systematic_name: M29488
exact_source: GO:0034338
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034338
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion, where the carboxylic chain has 8 or fewer carbon atoms. [GOC:jp]


systematic_name: M48631
exact_source: GO:0034432
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034432
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate. [PMID:10085096, PMID:9450008]


systematic_name: M18036
exact_source: GO:0034450
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034450
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Isoenergetic transfer of ubiquitin from one protein to an existing ubiquitin chain via the reaction X-ubiquitin + Y-ubiquitin = Y-ubiquitin-ubiquitin + X, where both the X-ubiquitin and Y-ubiquitin-ubiquitin linkages are thioester bonds between the C-terminal glycine of ubiquitin and a sulfhydryl side group of a cysteine residue. [GOC:mah, GOC:mcc, PMID:10089879, PMID:17190603]


systematic_name: M26586
exact_source: GO:0034452
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034452
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a dynactin complex; a large protein complex that activates dynein-based motor activity. [GOC:BHF, GOC:mah]


systematic_name: M26588
exact_source: GO:0034481
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034481
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin sulfate. [EC:2.8.2.17, EC:2.8.2.5, GOC:mah]


systematic_name: M17962
exact_source: GO:0034483
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034483
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + sulfated heparan sulfate. [GOC:mah]


systematic_name: M43202
exact_source: GO:0034485
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034485
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate. [EC:3.1.3.86, GOC:pf]


systematic_name: M43203
exact_source: GO:0034584
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034584
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a piRNA, a Piwi-associated RNA, a 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism. [GOC:kmv]


systematic_name: M26592
exact_source: GO:0034594
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034594
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylinositol trisphosphate + H2O = phosphatidylinositol bisphosphate + phosphate. [GOC:mah]


systematic_name: M43204
exact_source: GO:0034634
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034634
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other. [GOC:mah]


systematic_name: M46986
exact_source: GO:0034647
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034647
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a tri, a di or a monomethyl-lysine residue at position 4 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17550896, PMID:22473470]


systematic_name: M18860
exact_source: GO:0034979
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0034979
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: N(6)-acetyl-L-lysyl-[protein] + NAD+ + H2O = L-lysyl-[protein] + 2''-O-acetyl-ADP-D-ribose + nicotinamide. [GOC:BHF, GOC:mah, RHEA:43636]


systematic_name: M26597
exact_source: GO:0035005
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035005
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + ADP + 2 H+. [EC:2.7.1.154, RHEA:18373]


systematic_name: M48632
exact_source: GO:0035014
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035014
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Modulates the activity of a phosphatidylinositol 3-kinase (PI3K). Regulatory subunits can link a PI3K catalytic subunit to upstream signaling events and help position the catalytic subunits close to their lipid substrates. [GOC:bf, PMID:9255069]


systematic_name: M18286
exact_source: GO:0035091
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035091
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an inositol-containing glycerophospholipid, i.e. phosphatidylinositol (PtdIns) and its phosphorylated derivatives. [GOC:bf, ISBN:0198506732, PMID:11395417]


systematic_name: M26601
exact_source: GO:0035197
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035197
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a small interfering RNA, a 21-23 nucleotide RNA that is processed from double stranded RNA (dsRNA) by an RNAse enzyme. [PMID:15066275, PMID:15066283]


systematic_name: M18028
exact_source: GO:0035198
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035198
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a microRNA, a 21-23 nucleotide RNA that is processed from a stem-loop RNA precursor (pre-miRNA) that is encoded within plant and animal genomes. [PMID:15066283]


systematic_name: M18923
exact_source: GO:0035240
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035240
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. [ISBN:0198506732]


systematic_name: M34425
exact_source: GO:0035241
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035241
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the addition of a methyl group to either of the unmethylated terminal nitrogen atoms (also called omega nitrogen) in peptidyl-arginine to form an omega-N-G-monomethylated arginine residue. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-Nomega-methyl-L-arginine. [EC:2.1.1.321, PMID:14705965, RESID:AA0069]


systematic_name: M34426
exact_source: GO:0035242
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035242
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the addition of a second methyl group to methylated peptidyl-arginine. Methylation is on the same terminal nitrogen (omega nitrogen) residue that was previously methylated, resulting in asymmetrical peptidyl-N(omega),N(omega)-dimethylated arginine residues. [PMID:14705965]


systematic_name: M26603
exact_source: GO:0035251
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035251
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a glucosyl group from UDP-glucose to an acceptor molecule. [PMID:19858195]


systematic_name: M26604
exact_source: GO:0035252
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035252
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a xylosyl group from UDP-xylose to an acceptor molecule. [PMID:30127001]


systematic_name: M17872
exact_source: GO:0035255
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035255
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. [GOC:bf, ISBN:0198506732]


systematic_name: M26605
exact_source: GO:0035256
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035256
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a G protein-coupled glutamate receptor (a metabotropic glutamate receptor). [GOC:bf, ISBN:0198506732, PMID:9069287]


systematic_name: M26607
exact_source: GO:0035312
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035312
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of a DNA molecule. [ISBN:0198547684]


systematic_name: M26608
exact_source: GO:0035325
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035325
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a Toll-like protein, a pattern recognition receptor that binds pattern motifs from a variety of microbial sources to initiate an innate immune response. [PMID:19076341]


systematic_name: M26609
exact_source: GO:0035374
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035374
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to chondroitin sulfate, a glycosaminoglycan made up of two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). [GOC:kmv, ISBN:0198506732]


systematic_name: M26610
exact_source: GO:0035381
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035381
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts. [GOC:bf]


systematic_name: M18539
exact_source: GO:0035497
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035497
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP. [PMID:2875459, PMID:2900470]


systematic_name: M45362
exact_source: GO:0035514
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035514
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from one or more nucleosides within a DNA molecule. [GOC:bf]


systematic_name: M26612
exact_source: GO:0035515
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035515
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [PMID:12594517, PMID:16482161, PMID:18775698]


systematic_name: M18918
exact_source: GO:0035591
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035591
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity. [GOC:bf, PMID:19104498]


systematic_name: M40658
exact_source: GO:0035594
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035594
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues. [GOC:yaf]


systematic_name: M26615
exact_source: GO:0035612
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035612
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). [GOC:BHF, PMID:12221107, PMID:15728179, PMID:21097499]


systematic_name: M26616
exact_source: GO:0035613
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035613
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop. [GOC:sart, PMID:16568238, PMID:20455544]


systematic_name: M26618
exact_source: GO:0035650
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035650
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C). [PMID:21097499]


systematic_name: M43207
exact_source: GO:0035662
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035662
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response. [GOC:BHF, PMID:18304834]


systematic_name: M26619
exact_source: GO:0035671
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035671
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: an enone + NADPH + H+ = a ketone + NADP+. [GOC:kad, PMID:17945329, PMID:19166903]


systematic_name: M26620
exact_source: GO:0035673
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035673
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages. [GOC:vw, ISBN:0198506732]


systematic_name: M26621
exact_source: GO:0035727
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035727
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors. [GOC:curators]


systematic_name: M40659
exact_source: GO:0035925
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0035925
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs. [GOC:vw, PMID:31511872, PMID:7892223, PMID:8578590]


systematic_name: M19092
exact_source: GO:0036002
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036002
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]


systematic_name: M17877
exact_source: GO:0036041
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036041
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [GOC:pm, PMID:12641450]


systematic_name: M26626
exact_source: GO:0036310
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036310
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule. [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634, PMID:22888405]


systematic_name: M26627
exact_source: GO:0036312
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036312
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location. [GOC:bf, PMID:20505341]


systematic_name: M26628
exact_source: GO:0036374
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036374
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. [EC:3.4.19.13, GOC:imk]


systematic_name: M43209
exact_source: GO:0036402
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036402
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome. [GOC:rb, PMID:11430818]


systematic_name: M46004
exact_source: GO:0036408
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036408
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14). [GOC:vw, PMID:21289066]


systematic_name: M26630
exact_source: GO:0036435
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0036435
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein. [GOC:al, PMID:20739285]


systematic_name: M18649
exact_source: GO:0038024
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0038024
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span membranes (for instance the plasma membrane or the endoplasmic reticulum membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit the cargo molecules to nascent vesicles. [PMID:15239958, PMID:27903609]


systematic_name: M26632
exact_source: GO:0038036
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0038036
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, PMID:12728273, Wikipedia:S1PR1]


systematic_name: M26633
exact_source: GO:0038064
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0038064
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:bf, GOC:uh, PMID:21568710]


systematic_name: M46988
exact_source: GO:0038100
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0038100
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nodal protein, a member of the transforming growth factor-beta superfamily. [GOC:bf, PMID:20629020]


systematic_name: M26637
exact_source: GO:0038187
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0038187
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. [GOC:ar, GOC:bf]


systematic_name: M26638
exact_source: GO:0039706
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0039706
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell. [GOC:bf, GOC:jl]


systematic_name: M18776
exact_source: GO:0042043
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042043
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals. [GOC:curators, GOC:pr, PMID:18923512]


systematic_name: M19228
exact_source: GO:0042054
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042054
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or a lysine residue. [GOC:curators]


systematic_name: M18697
exact_source: GO:0042056
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042056
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal. [GOC:go_curators, ISBN:0198506732]


systematic_name: M18482
exact_source: GO:0042162
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042162
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end. [GOC:jl, SO:0000624]


systematic_name: M18573
exact_source: GO:0042166
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042166
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. [GOC:ai]


systematic_name: M12764
exact_source: GO:0042169
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042169
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class. [GOC:go_curators, Pfam:PF00017]


systematic_name: M3935
exact_source: GO:0042277
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042277
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl]


systematic_name: M18976
exact_source: GO:0042287
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042287
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a major histocompatibility complex molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]


systematic_name: M18641
exact_source: GO:0042288
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042288
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a major histocompatibility complex class I molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]


systematic_name: M26641
exact_source: GO:0042289
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042289
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a major histocompatibility complex class II molecule; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation. [GOC:jl]


systematic_name: M34428
exact_source: GO:0042392
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042392
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate. [GOC:jl, PMID:8663293]


systematic_name: M17924
exact_source: GO:0042393
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042393
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription. [GOC:jl, PMID:16209651, PMID:30212449, PMID:9305837]


systematic_name: M26643
exact_source: GO:0042500
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042500
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane. [GOC:jl, ISBN:0198506732]


systematic_name: M9558
exact_source: GO:0042562
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042562
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an hormone, a naturally occurring substance secreted by specialized cells that affect the metabolism or behavior of cells possessing functional receptors for the hormone. Hormones may be produced by the same, or different, cell as express the receptor. [GOC:jl]


systematic_name: M18348
exact_source: GO:0042578
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042578
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. [GOC:jl]


systematic_name: M26646
exact_source: GO:0042609
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042609
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a CD4, a receptor found on the surface of T cells, monocytes and macrophages. [GOC:jl, MSH:D015704]


systematic_name: M46989
exact_source: GO:0042625
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042625
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M43210
exact_source: GO:0042626
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042626
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M45363
exact_source: GO:0042731
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042731
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. [GOC:jl, Pfam:PF00169]


systematic_name: M26647
exact_source: GO:0042799
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042799
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group to the lysine residue at position 20 of the histone H4 protein. [PMID:12086618]


systematic_name: M19113
exact_source: GO:0042800
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042800
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of up to three methyl groups to the lysine residue at position 4 of the histone H3 protein. [PMID:12086618]


systematic_name: M18366
exact_source: GO:0042805
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042805
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to actinin, any member of a family of proteins that crosslink F-actin. [GOC:jl, ISBN:0198506732]


systematic_name: M18261
exact_source: GO:0042809
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042809
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nuclear vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes. [GOC:jl, PMID:12637589]


systematic_name: M18686
exact_source: GO:0042813
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042813
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:go_curators]


systematic_name: M18879
exact_source: GO:0042834
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042834
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. [GOC:go_curators, PMID:14698226]


systematic_name: M18240
exact_source: GO:0042887
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042887
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of a membrane to the other. [GOC:jl, ISBN:0198506732]


systematic_name: M29492
exact_source: GO:0042910
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042910
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc]


systematic_name: M4273
exact_source: GO:0042923
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042923
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators). [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]


systematic_name: M48633
exact_source: GO:0042937
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042937
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a tripeptide, a compound containing three amino acids linked together by peptide bonds, from one side of a membrane to the other. [GOC:jl]


systematic_name: M18772
exact_source: GO:0042974
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042974
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nuclear retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily. [GOC:jl, PMID:12476796]


systematic_name: M18893
exact_source: GO:0042975
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0042975
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a peroxisome proliferator activated receptor, alpha, beta or gamma. [GOC:jl, PMID:12769781]


systematic_name: M18466
exact_source: GO:0043027
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043027
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]


systematic_name: M19227
exact_source: GO:0043028
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043028
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process. [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]


systematic_name: M34429
exact_source: GO:0043035
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043035
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription. [GOC:jl, PMID:12783795]


systematic_name: M34431
exact_source: GO:0043120
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043120
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages. [GOC:jl, http://lookwayup.com/]


systematic_name: M26654
exact_source: GO:0043121
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043121
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth. [GOC:jl]


systematic_name: M26655
exact_source: GO:0043130
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043130
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation. [GOC:ecd]


systematic_name: M18443
exact_source: GO:0043175
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043175
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme. [GOC:jl, GOC:txnOH]


systematic_name: M18373
exact_source: GO:0043176
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043176
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group. [GOC:jl]


systematic_name: M18642
exact_source: GO:0043177
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043177
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an organic acid, any acidic compound containing carbon in covalent linkage. [GOC:jl, ISBN:0198506732]


systematic_name: M18268
exact_source: GO:0043178
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043178
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group. [GOC:jl, ISBN:0198506732]


systematic_name: M26660
exact_source: GO:0043208
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043208
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide. [GOC:jl]


systematic_name: M43211
exact_source: GO:0043225
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043225
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). [GOC:mlg]


systematic_name: M26661
exact_source: GO:0043237
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043237
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1. [GOC:go_curators]


systematic_name: M46991
exact_source: GO:0043273
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043273
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: CTP + H2O = CDP + H+ + phosphate. May or may not be coupled to another reaction. [RHEA:29387]


systematic_name: M18936
exact_source: GO:0043325
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043325
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions. [GOC:bf, GOC:go_curators]


systematic_name: M18556
exact_source: GO:0043394
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043394
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans. [ISBN:0198506732]


systematic_name: M18662
exact_source: GO:0043395
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043395
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit. [ISBN:0198506732]


systematic_name: M26662
exact_source: GO:0043422
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043422
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, http://www.heartandmetabolism.org/]


systematic_name: M17935
exact_source: GO:0043425
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043425
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways. [PMID:9144210]


systematic_name: M29494
exact_source: GO:0043426
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043426
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors. [PMID:10966875]


systematic_name: M26663
exact_source: GO:0043495
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043495
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together a protein or a protein complex with a membrane, or bringing together two membranes, either via membrane lipid binding or by interacting with a membrane protein, to establish or maintain the localization of the protein, protein complex or organelle. [GOC:go_curators]


systematic_name: M26664
exact_source: GO:0043515
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043515
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached. [GOC:jl]


systematic_name: M18013
exact_source: GO:0043522
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043522
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. [GOC:jl, InterPro:IPR002158]


systematic_name: M26666
exact_source: GO:0043546
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043546
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. [ISSN:09498257]


systematic_name: M18733
exact_source: GO:0043548
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043548
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring. [PMID:10209156, PMID:9255069]


systematic_name: M26667
exact_source: GO:0043559
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043559
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [ISBN:0198506732]


systematic_name: M18901
exact_source: GO:0043560
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043560
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an insulin receptor substrate (IRS) protein, an adaptor protein that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex. [PMID:12829233]


systematic_name: M19027
exact_source: GO:0043565
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043565
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl]


systematic_name: M43212
exact_source: GO:0043813
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043813
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. [PMID:10806194, PMID:16607019, RHEA:32955]


systematic_name: M48634
exact_source: GO:0043855
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043855
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts. [GOC:jl]


systematic_name: M26668
exact_source: GO:0043878
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043878
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+. [PMID:9497334]


systematic_name: M46007
exact_source: GO:0043995
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043995
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5). [EC:2.3.1.48]


systematic_name: M46008
exact_source: GO:0043997
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0043997
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12). [EC:2.3.1.48]


systematic_name: M26670
exact_source: GO:0044183
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0044183
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein or a protein-containing complex to assist the protein folding process. [GOC:mtg_cambridge_2009]


systematic_name: M29495
exact_source: GO:0044323
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0044323
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind. [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671]


systematic_name: M18553
exact_source: GO:0044325
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0044325
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]


systematic_name: M18713
exact_source: GO:0044390
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0044390
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme. [GOC:jl]


systematic_name: M18228
exact_source: GO:0044548
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0044548
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]


systematic_name: M34434
exact_source: GO:0045028
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045028
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:mah, PMID:9755289]


systematic_name: M18869
exact_source: GO:0045125
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045125
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes. [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]


systematic_name: M46992
exact_source: GO:0045145
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045145
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule. [GOC:ai, GOC:elh, PMID:20086101]


systematic_name: M26676
exact_source: GO:0045159
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045159
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


systematic_name: M1220
exact_source: GO:0045182
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045182
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. [GOC:ai]


systematic_name: M34436
exact_source: GO:0045322
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045322
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to uan nmethylated CpG motif. Unmethylated CpG dinucleotides are often associated with gene promoters. [GOC:ai, PMID:10688657]


systematic_name: M18961
exact_source: GO:0045499
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045499
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal. [GOC:ai]


systematic_name: M26681
exact_source: GO:0045545
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045545
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells. [GOC:go_curators, PMID:9355727]


systematic_name: M26682
exact_source: GO:0045569
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0045569
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to TRAIL (TNF-related apoptosis inducing ligand), a member of the tumor necrosis factor ligand family that rapidly induces apoptosis in a variety of transformed cell lines. [GOC:go_curators, PMID:9082980]


systematic_name: M19203
exact_source: GO:0046030
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046030
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: myo-inositol trisphosphate + H2O = myo-inositol bisphosphate + phosphate. [GOC:bf]


systematic_name: M19003
exact_source: GO:0046527
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046527
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a glucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732]


systematic_name: M26683
exact_source: GO:0046624
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046624
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ai, ISBN:0198506732]


systematic_name: M26684
exact_source: GO:0046625
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046625
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sphingolipid, a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [ISBN:0198506732]


systematic_name: M18904
exact_source: GO:0046906
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046906
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a tetrapyrrole, a compound containing four pyrrole nuclei variously substituted and linked to each other through carbons at the alpha position. [GOC:curators, ISBN:0198506732]


systematic_name: M26688
exact_source: GO:0046912
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046912
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. [GOC:jl]


systematic_name: M11903
exact_source: GO:0046914
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046914
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a transition metal ions; a transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]


systematic_name: M18477
exact_source: GO:0046915
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046915
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of transition metal ions from one side of a membrane to the other. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver. [ISBN:0198506732]


systematic_name: M26689
exact_source: GO:0046920
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046920
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->3) linkage. [GOC:ai]


systematic_name: M26690
exact_source: GO:0046923
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046923
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an endoplasmic reticulum (ER) retention sequence, a specific peptide sequence that ensures a protein is retained within the ER. [GOC:ai]


systematic_name: M19007
exact_source: GO:0046933
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046933
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + H2O + phosphate + H+(in) -> ATP + H+(out). [RHEA:57722]


systematic_name: M43214
exact_source: GO:0046934
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046934
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+. [EC:2.7.1.153, RHEA:21292]


systematic_name: M46009
exact_source: GO:0046972
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046972
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 16) = CoA + histone H4 N6-acetyl-L-lysine (position 16). This reaction represents the addition of an acetyl group to the lysine at position 16 of histone H4. [EC:2.3.1.48]


systematic_name: M26693
exact_source: GO:0046974
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046974
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of up to three methyl groups to the lysine residue at position 9 of the histone H3 protein. [GOC:ai]


systematic_name: M26694
exact_source: GO:0046975
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046975
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 36) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 36). This reaction is the addition of a methyl group to the lysine residue at position 36 of the histone H3 protein. [GOC:ai]


systematic_name: M46010
exact_source: GO:0046976
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046976
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 27) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 27). This reaction is the addition of a methyl group to the lysine residue at position 27 of the histone H3 protein. [GOC:ai]


systematic_name: M34438
exact_source: GO:0046977
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046977
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. [PMID:11133832]


systematic_name: M18046
exact_source: GO:0046983
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0046983
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. [ISBN:0198506732]


systematic_name: M40662
exact_source: GO:0047024
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047024
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 5alpha-androstane-3beta,17beta-diol + NADP+ = 17beta-hydroxy-5alpha-androstan-3-one + H+ + NADPH. [EC:1.1.1.210, RHEA:16297]


systematic_name: M40663
exact_source: GO:0047044
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047044
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN]


systematic_name: M40664
exact_source: GO:0047045
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047045
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NADP+ + testosterone = NADPH + H+ + androst-4-ene-3,17-dione. [EC:1.1.1.64, MetaCyc:1.1.1.64-RXN]


systematic_name: M26697
exact_source: GO:0047086
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047086
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: O2 + NADPH + progesterone = H2O + NADP+ + testosterone acetate. [EC:1.14.13.54, MetaCyc:1.14.13.54-RXN]


systematic_name: M48635
exact_source: GO:0047134
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047134
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: protein-dithiol + NAD(P)+ = protein-disulfide + NAD(P)H + H+. [EC:1.8.1.8, MetaCyc:1.6.4.4-RXN]


systematic_name: M43216
exact_source: GO:0047144
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047144
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 2-acyl-sn-glycerol 3-phosphate + acyl-CoA = L-phosphatidate + CoA. [GOC:ab, RHEA:14233]


systematic_name: M26698
exact_source: GO:0047184
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047184
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine + acyl-CoA = phosphatidylcholine + CoA. [EC:2.3.1.23, MetaCyc:2.3.1.23-RXN]


systematic_name: M34440
exact_source: GO:0047238
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047238
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP-N-acetylgalactosamine = N-acetyl-D-galactosaminyl-1,4-beta-D-glucuronyl-N-acetyl-1,3-beta-D-galactosaminylproteoglycan + UDP. [EC:2.4.1.175, MetaCyc:2.4.1.175-RXN]


systematic_name: M26699
exact_source: GO:0047372
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047372
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: H2O + acylglycerol = a fatty acid + glycerol. [EC:3.1.1.23, MetaCyc:3.1.1.23-RXN]


systematic_name: M26700
exact_source: GO:0047429
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047429
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a nucleoside triphosphate + H2O = a nucleotide + H+ + diphosphate. [EC:3.6.1.9]


systematic_name: M26701
exact_source: GO:0047498
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047498
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction requires Ca2+. [EC:3.1.1.4]


systematic_name: M26702
exact_source: GO:0047499
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047499
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate. This reaction does not require Ca2+. [EC:3.1.1.4]


systematic_name: M26703
exact_source: GO:0047631
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047631
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ADP-ribose + H2O = AMP + D-ribose 5-phosphate. [EC:3.6.1.13, MetaCyc:ADP-RIBOSE-PYROPHOSPHATASE-RXN]


systematic_name: M29497
exact_source: GO:0047676
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047676
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: arachidonate + ATP + CoA = AMP + arachidonoyl-CoA + diphosphate + H+. [RHEA:19713]


systematic_name: M26705
exact_source: GO:0047961
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0047961
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acyl-CoA + glycine = CoA + N-acylglycine. [EC:2.3.1.13, MetaCyc:GLYCINE-N-ACYLTRANSFERASE-RXN]


systematic_name: M26706
exact_source: GO:0048019
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048019
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The activity of a gene product that interacts with a receptor to decrease the ability of the receptor agonist to bind and activate the receptor. [GOC:ceb, ISBN:0198506732]


systematic_name: M6223
exact_source: GO:0048029
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048029
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a monosaccharide. Monosaccharides are the simplest carbohydrates; they are polyhydroxy aldehydes H[CH(OH)]nC(=O)H or polyhydroxy ketones H[CHOH]nC(=O)[CHOH]mH with three or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. [GOC:jid]


systematic_name: M17900
exact_source: GO:0048038
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048038
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. [ISBN:0198506732]


systematic_name: M26708
exact_source: GO:0048039
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048039
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to ubiquinone, a quinone derivative with a tail of isoprene units. [GOC:jid, ISBN:0582227089]


systematic_name: M17965
exact_source: GO:0048156
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048156
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to tau protein. tau is a microtubule-associated protein, implicated in Alzheimer's disease, Down Syndrome and ALS. [GOC:jid]


systematic_name: M26710
exact_source: GO:0048256
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048256
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA synthesis. [GOC:jid]


systematic_name: M26711
exact_source: GO:0048273
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048273
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to mitogen-activated protein kinase p38, an enzyme that catalyzes the transfer of phosphate from ATP to hydroxyl side chains on proteins in response to mitogen activation. [GOC:curators, PMID:17827184]


systematic_name: M26713
exact_source: GO:0048495
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048495
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to Roundabout (ROBO) receptor, a transmembrane receptor. [GOC:ecd, PMID:10102268, PMID:10197527]


systematic_name: M18409
exact_source: GO:0048531
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048531
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a galactose residue from a donor molecule to an oligosaccharide, forming a beta-1,3-linkage. [PMID:11551958]


systematic_name: M46994
exact_source: GO:0048763
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0048763
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables transmembrane transfer of calcium ions from an intracellular store to the cytosol on induction by increased calcium concentration. [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]


systematic_name: M26715
exact_source: GO:0050145
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050145
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + nucleoside monophosphate = ADP + nucleoside diphosphate. [GOC:ai, ISBN:0198506732]


systematic_name: M26716
exact_source: GO:0050291
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050291
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine. [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]


systematic_name: M19067
exact_source: GO:0050321
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050321
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein. [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]


systematic_name: M18288
exact_source: GO:0050431
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050431
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types. [ISBN:0198506732]


systematic_name: M26717
exact_source: GO:0050542
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050542
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids. [ISBN:0198506732]


systematic_name: M26720
exact_source: GO:0050656
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050656
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems. [GOC:ai]


systematic_name: M18994
exact_source: GO:0050660
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050660
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. [GOC:ai, GOC:imk, ISBN:0198506732]


systematic_name: M18782
exact_source: GO:0050661
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050661
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. [GOC:ai]


systematic_name: M18682
exact_source: GO:0050664
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050664
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule. [EC:1.6.3.-]


systematic_name: M26721
exact_source: GO:0050693
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050693
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein's ligand binding domain (LBD) domain, found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket. [PMID:9682036]


systematic_name: M18529
exact_source: GO:0050699
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050699
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions. [PMID:14531730]


systematic_name: M26722
exact_source: GO:0050700
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050700
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family. [PMID:12054670]


systematic_name: M45365
exact_source: GO:0050733
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050733
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing. [PMID:11684676, PMID:12215544]


systematic_name: M26725
exact_source: GO:0050833
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050833
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of pyruvate, 2-oxopropanoate, from one side of a membrane to the other. [GOC:ai]


systematic_name: M18701
exact_source: GO:0050997
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0050997
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [GOC:ai]


systematic_name: M9766
exact_source: GO:0051015
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051015
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]


systematic_name: M18579
exact_source: GO:0051087
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051087
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443]


systematic_name: M18351
exact_source: GO:0051119
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051119
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a sugar from one side of a membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M29499
exact_source: GO:0051139
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051139
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in). [GOC:mlg]


systematic_name: M18375
exact_source: GO:0051213
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051213
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]


systematic_name: M18577
exact_source: GO:0051287
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051287
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. [GOC:ai]


systematic_name: M26730
exact_source: GO:0051371
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051371
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to muscle isoforms of actinin. Muscle alpha-actinin isoforms are found in skeletal and cardiac muscle and are localized to the Z-disc. [PMID:10984498, PMID:11699871, PMID:15014165]


systematic_name: M26731
exact_source: GO:0051373
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051373
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the FATZ family of proteins, filamin-, actinin-, and telethonin-binding proteins of the Z-disc of striated muscle. FATZ proteins are located in the Z-disc of the sarcomere and are involved in a complex network of interactions with other Z-band components. [PMID:10984498, PMID:11699871]


systematic_name: M48637
exact_source: GO:0051378
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051378
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai]


systematic_name: M26732
exact_source: GO:0051379
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051379
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai]


systematic_name: M18989
exact_source: GO:0051393
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051393
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to alpha-actinin, one of a family of proteins that cross-link F-actin as antiparallel homodimers. Alpha-actinin has a molecular mass of 93-103 KDa; at the N-terminus there are two calponin homology domains, at the C-terminus there are two EF-hands. These two domains are connected by the rod domain. This domain is formed by triple-helical spectrin repeats. [PMID:10984498, PMID:11699871, PMID:15014165]


systematic_name: M26734
exact_source: GO:0051400
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051400
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409]


systematic_name: M26735
exact_source: GO:0051429
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051429
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a receptor for corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. It is released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland. [GOC:ai]


systematic_name: M26736
exact_source: GO:0051434
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051434
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259]


systematic_name: M26737
exact_source: GO:0051525
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051525
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to NFAT (nuclear factor of activated T cells) proteins, a family of transcription factors. NFAT proteins have crucial roles in the development and function of the immune system. [PMID:15928679]


systematic_name: M18987
exact_source: GO:0051537
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051537
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]


systematic_name: M19161
exact_source: GO:0051539
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051539
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. [GOC:ai, PMID:15952888, Wikipedia:Iron-sulfur_cluster]


systematic_name: M18616
exact_source: GO:0051540
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051540
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a cluster of atoms including both metal ions and nonmetal atoms, usually sulfur and oxygen. Examples include iron-sulfur clusters and nickel-iron-sulfur clusters. [GOC:jsg]


systematic_name: M26738
exact_source: GO:0051575
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051575
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site in DNA where a DNA-(apurinic or apyrimidinic site) lyase has already cleaved the C-O-P bond 3' to the apurinic or apyrimidinic site. [PMID:11251121, PMID:16120966]


systematic_name: M46011
exact_source: GO:0051765
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051765
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. [GOC:ai]


systematic_name: M18495
exact_source: GO:0051861
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051861
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. [PMID:19635802]


systematic_name: M26739
exact_source: GO:0051864
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051864
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16362057]


systematic_name: M26740
exact_source: GO:0051880
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0051880
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to G-quadruplex DNA structures, in which groups of four guanines adopt a flat, cyclic Hoogsteen hydrogen-bonding arrangement known as a guanine tetrad. The stacking of guanine tetrads results in G-quadruplex DNA structures. G-quadruplex DNA can form under physiological conditions from some G-rich sequences, such as those found in telomeres, immunoglobulin switch regions, gene promoters, fragile X repeats, and the dimerization domain in the human immunodeficiency virus (HIV) genome. [PMID:16142245, PMID:9512530]


systematic_name: M17992
exact_source: GO:0052629
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052629
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. [PMID:19901554, RHEA:39019]


systematic_name: M43219
exact_source: GO:0052642
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052642
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: lysophosphatidic acid + H2O = phosphate + monoacylglycerol. [PMID:20045079, PMID:7966317]


systematic_name: M43220
exact_source: GO:0052658
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052658
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. [EC:3.1.3.56, RHEA:19797]


systematic_name: M43221
exact_source: GO:0052739
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052739
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylserine + H2O = 2-acyl-sn-glycero-3-phosphoserine + fatty acid. [KEGG_REACTION:R04034]


systematic_name: M18451
exact_source: GO:0052742
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052742
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + a phosphatidylinositol = ADP + a phosphatidylinositol phosphate. [GOC:ai]


systematic_name: M18218
exact_source: GO:0052743
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052743
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: myo-inositol tetrakisphosphate + H2O = myo-inositol trisphosphate + phosphate. [GOC:ai]


systematic_name: M18045
exact_source: GO:0052744
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052744
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidyl-1D-myo-inositol monophosphate + H2O = phosphatidylinositol + phosphate. [GOC:ai]


systematic_name: M18633
exact_source: GO:0052745
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052745
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: inositol phosphate(n) + H2O = inositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from an inositol phosphate. [GOC:ai]


systematic_name: M48638
exact_source: GO:0052816
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052816
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [RHEA:67680]


systematic_name: M17963
exact_source: GO:0052866
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052866
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylinositol phosphate(n) + H2O = phosphatidylinositol phosphate(n-1) + phosphate. This reaction is the removal of a phosphate group from a phosphatidylinositol phosphate. [GOC:ai]


systematic_name: M45367
exact_source: GO:0052890
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0052890
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a flavin. [GOC:jl]


systematic_name: M43222
exact_source: GO:0055077
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0055077
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction. [GOC:dgh]


systematic_name: M18446
exact_source: GO:0055102
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0055102
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:rl]


systematic_name: M26747
exact_source: GO:0055105
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0055105
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a ubiquitin-protein transferase. [GOC:BHF, GOC:rl]


systematic_name: M26748
exact_source: GO:0055106
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0055106
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein. [GOC:BHF, GOC:rl]


systematic_name: M26749
exact_source: GO:0055131
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0055131
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a C3HC4-type zinc finger domain of a protein. The C3HC4-type zinc finger is a variant of RING finger, is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid. Many proteins containing a C3HC4-type RING finger play a key role in the ubiquitination pathway. [GOC:amm, InterPro:IPR001841, InterPro:IPR018957]


systematic_name: M26750
exact_source: GO:0060089
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0060089
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A compound molecular function in which an effector function is controlled by one or more regulatory components. [GOC:dos, GOC:pdt]


systematic_name: M3632
exact_source: GO:0060090
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0060090
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way. [GOC:mtg_MIT_16mar07, GOC:vw]


systematic_name: M26752
exact_source: GO:0060228
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0060228
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of phosphatidylcholine-sterol O-acyltransferase. [GOC:BHF, GOC:dph, GOC:tb, PMID:4335615]


systematic_name: M18651
exact_source: GO:0060229
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0060229
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of a lipase, an enzyme that catalyzes of the hydrolysis of a lipid. [GOC:BHF, GOC:dph, GOC:tb]


systematic_name: M17907
exact_source: GO:0061134
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061134
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds. [GOC:dph, GOC:tb]


systematic_name: M26754
exact_source: GO:0061135
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061135
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates the activity of a peptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides. [GOC:dph, GOC:tb]


systematic_name: M26755
exact_source: GO:0061575
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061575
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]


systematic_name: M26756
exact_source: GO:0061578
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061578
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys63 residue of ubiquitin. [GOC:dph, GOC:pg, PMID:18313383]


systematic_name: M26757
exact_source: GO:0061608
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061608
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a nuclear import signal (NIS) on a cargo to be transported, to mediate transport of the cargo through the nuclear pore, from the cytoplasm to the nuclear lumen. The cargo can be either a RNA or a protein. [GOC:dph, GOC:pg, GOC:vw, PMID:28713609, Wikipedia:Nuclear_transport]


systematic_name: M26758
exact_source: GO:0061629
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061629
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sequence-specific DNA binding RNA polymerase II transcription factor, any of the factors that interact selectively and non-covalently with a specific DNA sequence in order to modulate transcription. [GOC:dph, GOC:vw]


systematic_name: M46997
exact_source: GO:0061649
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061649
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular adaptor that recognizes and binds a histone protein containing a ubiquitination modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. [GOC:dph, PMID:24526689]


systematic_name: M18055
exact_source: GO:0061650
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061650
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Isoenergetic transfer of a ubiquitin-like protein (ULP) from one protein to another molecule, usually another protein, via the reaction X-SCP + Y = Y-SCP + X, where both the X-SCP and Y-SCP linkages are thioester bonds between the C-terminal amino acid of SCP and a sulfhydryl side group of a cysteine residue. [GOC:dph]


systematic_name: M18729
exact_source: GO:0061659
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061659
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a ubiquitin-like protein (ULP) to a substrate protein via the reaction X-ULP + S = X + S-ULP, where X is either an E2 or E3 enzyme, the X-ULP linkage is a thioester bond, and the S-ULP linkage is an isopeptide bond between the C-terminal glycine of ULP and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]


systematic_name: M26759
exact_source: GO:0061665
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061665
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of SUMO to a substrate protein via the reaction X-SUMO + S = X + S-SUMO, where X is either an E2 or E3 enzyme, the X-SUMO linkage is a thioester bond, and the S-SUMO linkage is an isopeptide bond between the C-terminal amino acid of SUMO and the epsilon-amino group of lysine residues in the substrate. [GOC:dph]


systematic_name: M34445
exact_source: GO:0061733
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061733
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + lysine in peptide = CoA + N-acetyl-lysine-peptide. [GOC:dph, RHEA:45948]


systematic_name: M26761
exact_source: GO:0061783
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061783
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A catalytic activity that contributes to the degradation of peptidoglycan. [GOC:dph, GOC:jh, PMID:22748813]


systematic_name: M48639
exact_source: GO:0061809
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061809
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose, in a two steps reaction: first an ADP-ribosyl cyclase reaction, followed by a cyclic ADP-ribose hydrolase reaction. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528]


systematic_name: M26762
exact_source: GO:0061980
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0061980
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a small regulatory RNA, a short RNA (usually 50-200 nt long) that is either independently transcribed or processed from a longer RNA by an RNAse enzyme. [PMID:14622403, PMID:23475961]


systematic_name: M40665
exact_source: GO:0062037
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0062037
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA D-loop. A D-loop is a three-stranded DNA structure formed by the invasion of a single DNA strand that base pairs with one strand of duplex DNA, while the rest of the double-stranded DNA does not unwind. [PMID:20924116]


systematic_name: M26763
exact_source: GO:0062105
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0062105
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + RNA = S-adenosyl-L-homocysteine + RNA containing 2'-O-methylribonucleotide. [PMID:30626973, RHEA:58956]


systematic_name: M19143
exact_source: GO:0070001
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070001
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


systematic_name: M18419
exact_source: GO:0070003
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070003
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


systematic_name: M29503
exact_source: GO:0070004
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070004
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of C- or N-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]


systematic_name: M19051
exact_source: GO:0070006
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070006
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE]


systematic_name: M17886
exact_source: GO:0070008
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070008
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]


systematic_name: M19192
exact_source: GO:0070016
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070016
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an armadillo repeat domain, an approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity protein armadillo. Arm-repeat proteins are involved in various processes, including intracellular signaling and cytoskeletal regulation. [GOC:BHF, GOC:mah, GOC:vk, InterPro:IPR000225]


systematic_name: M46998
exact_source: GO:0070051
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070051
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to fibrinogen, a highly soluble hexameric glycoprotein complex that is found in blood plasma and is converted to fibrin by thrombin in the coagulation cascade. [GOC:BHF, GOC:mah, GOC:vk]


systematic_name: M26764
exact_source: GO:0070061
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070061
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to the D- or L-enantiomer of fructose, the ketohexose arabino-hex-2-ulose. [CHEBI:28757, GOC:BHF, GOC:mah]


systematic_name: M18753
exact_source: GO:0070064
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070064
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein. [GOC:mah]


systematic_name: M26765
exact_source: GO:0070087
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070087
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a chromo shadow domain, a protein domain that is distantly related, and found in association with, the chromo domain. [GOC:BHF, GOC:vk, InterPro:IPR008251, PMID:7667093]


systematic_name: M43223
exact_source: GO:0070137
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070137
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of peptide bonds between an alpha-carboxyl group and an alpha-amino group within a small protein such as ubiquitin or a ubiquitin-like protein (e.g. APG8, ISG15, NEDD8, SUMO). [GOC:mah]


systematic_name: M26768
exact_source: GO:0070180
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070180
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. [GOC:elh]


systematic_name: M26769
exact_source: GO:0070181
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070181
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to small ribosomal subunit RNA (SSU rRNA), a constituent of the small ribosomal subunit. In S. cerevisiae, this is the 18S rRNA. [GOC:elh]


systematic_name: M19214
exact_source: GO:0070273
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070273
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position. [GOC:bf, GOC:mah]


systematic_name: M26770
exact_source: GO:0070279
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070279
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a vitamin B6 compound: pyridoxal, pyridoxamine, pyridoxine, or the active form, pyridoxal phosphate. [GOC:mah]


systematic_name: M18861
exact_source: GO:0070300
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070300
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidic acid, any of a class of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids. [CHEBI:16337, GOC:jp, ISBN:0198506732]


systematic_name: M26772
exact_source: GO:0070324
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070324
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. [GOC:rph]


systematic_name: M18204
exact_source: GO:0070402
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070402
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to the reduced form, NADPH, of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]


systematic_name: M26774
exact_source: GO:0070403
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070403
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions. [GOC:mah]


systematic_name: M26775
exact_source: GO:0070492
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070492
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an oligosaccharide, a molecule with between two and (about) 20 monosaccharide residues connected by glycosidic linkages. [GOC:mah]


systematic_name: M26776
exact_source: GO:0070513
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070513
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a death domain of a protein. The death domain (DD) is a homotypic protein interaction module composed of a bundle of six alpha-helices. DD bind each other forming oligomers. Some DD-containing proteins are involved in the regulation of apoptosis and inflammation through their activation of caspases and NF-kappaB. [GOC:BHF, GOC:rl, InterPro:IPR000488, Pfam:PF00531]


systematic_name: M26777
exact_source: GO:0070530
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070530
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 63 in the target protein. [GOC:mah, PMID:15556404, PMID:17525341]


systematic_name: M34446
exact_source: GO:0070573
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070573
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


systematic_name: M18042
exact_source: GO:0070628
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070628
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a proteasome, a large multisubunit protein complex that catalyzes protein degradation. [GOC:mah]


systematic_name: M45368
exact_source: GO:0070696
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070696
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a receptor that spans a cell membrane and possesses protein serine/threonine kinase activity. [GOC:BHF, GOC:mah]


systematic_name: M26786
exact_source: GO:0070739
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070739
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the posttranslational transfer of one or more glutamate residues to a specific residue on a target protein. [GOC:mah, PMID:19524510]


systematic_name: M18057
exact_source: GO:0070742
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070742
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a C2H2-type zinc finger domain of a protein. The C2H2 zinc finger is the classical zinc finger domain, in which two conserved cysteines and histidines co-ordinate a zinc ion. [GOC:BHF, GOC:mah, Pfam:PF00096]


systematic_name: M26787
exact_source: GO:0070840
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070840
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a dynein complex, a protein complex that contains two or three dynein heavy chains and several light chains, and has microtubule motor activity. [GOC:bf, GOC:BHF, GOC:mah]


systematic_name: M26788
exact_source: GO:0070878
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070878
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a primary microRNA (pri-miRNA) transcript, an RNA molecule that is processed into a short hairpin-shaped structure called a pre-miRNA and finally into a functional miRNA. Both double-stranded and single-stranded regions of a pri-miRNA are required for binding. [GOC:sl, PMID:15531877, PMID:15574589]


systematic_name: M26789
exact_source: GO:0070883
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070883
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a precursor microRNA (pre-miRNA) transcript, a stem-loop-containing precursor of microRNA. [PMID:18951094]


systematic_name: M18303
exact_source: GO:0070888
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070888
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an E-box, a DNA motif with the consensus sequence CANNTG that is found in the promoters of a wide array of genes expressed in neurons, muscle and other tissues. [GOC:BHF, GOC:vk, PMID:11812799]


systematic_name: M34447
exact_source: GO:0070915
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070915
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the phospholipid derivative lysophosphatidic acid, and transmitting the signal across the membrane by activating an associated G-protein. [GOC:bf, GOC:mah, PMID:15755723]


systematic_name: M47000
exact_source: GO:0070974
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070974
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a POU domain of a protein. The POU domain is a bipartite DNA binding domain composed of two subunits separated by a non-conserved region of 15-55 amino acids; it is found in several eukaryotic transcription factors. [GOC:mah, GOC:yaf, InterPro:IPR000327]


systematic_name: M46013
exact_source: GO:0071077
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071077
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of adenosine 3',5'-bisphosphate from one side of a membrane to the other. [GOC:mah]


systematic_name: M26791
exact_source: GO:0071253
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071253
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a connexin, any of a group of related proteins that assemble to form gap junctions. [GOC:mah, PMID:19864490]


systematic_name: M26792
exact_source: GO:0071532
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071532
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an ankyrin repeat of a protein. Ankyrin repeats are tandemly repeated modules of about 33 amino acids; each repeat folds into a helix-loop-helix structure with a beta-hairpin/loop region projecting out from the helices at a 90-degree angle, and repeats stack to form an L-shaped structure. [GOC:mah, InterPro:IPR002110]


systematic_name: M26793
exact_source: GO:0071558
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071558
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a tri- or a dimethyl-lysine residue at position 27 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [GOC:sp, PMID:20622853]


systematic_name: M26794
exact_source: GO:0071723
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071723
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a lipopeptide, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds and containing a nonprotein group consisting of a lipid or lipids. [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]


systematic_name: M18026
exact_source: GO:0071814
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071814
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein-lipid complex, any macromolecular complex that contains both protein and lipid molecules. [GOC:BHF, GOC:mah]


systematic_name: M18516
exact_source: GO:0071837
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071837
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an HMG box domain, a protein domain that consists of three helices in an irregular array. HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. [GOC:yaf, InterPro:IPR009071, PMID:18445004]


systematic_name: M18423
exact_source: GO:0071889
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071889
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins. [GOC:cna, GOC:mah, PMID:15167810, PMID:19575580]


systematic_name: M48641
exact_source: GO:0071916
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071916
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a dipeptide from one side of a membrane to the other. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond. [GOC:mah]


systematic_name: M26795
exact_source: GO:0071933
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071933
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an Arp2/3 complex, a protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5). [GOC:mah]


systematic_name: M18188
exact_source: GO:0071949
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071949
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:mah]


systematic_name: M26797
exact_source: GO:0071987
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071987
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a WD40 repeat domain of a protein. The WD40 repeat is a short structural motif of approximately 40 amino acids, often terminating in a tryptophan-aspartic acid (W-D) dipeptide. Several of these repeats are combined to form a type of protein domain called the WD domain. [GOC:yaf, InterPro:IPR017986]


systematic_name: M26798
exact_source: GO:0072345
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072345
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ion by a channel that opens when nicotinic acid adenine dinucleotide phosphate (NAADP) has been bound by the channel complex or one of its constituent parts. [PMID:19387438, PMID:19557428]


systematic_name: M45370
exact_source: GO:0072572
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072572
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to polymeric ADP-D-ribose, a polymer that is composed of poly-ADP-D-ribose units linked through 1,2-glycosidic bonds at the ribose ring. [GOC:mah, GOC:sart, PMID:20088964]


systematic_name: M17889
exact_source: GO:0080025
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0080025
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-3,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 5' positions. [GOC:bf, PMID:18397324]


systematic_name: M26800
exact_source: GO:0086006
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0086006
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]


systematic_name: M26801
exact_source: GO:0086007
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0086007
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]


systematic_name: M26802
exact_source: GO:0086008
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0086008
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]


systematic_name: M43226
exact_source: GO:0086075
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0086075
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]


systematic_name: M26803
exact_source: GO:0086080
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0086080
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein or protein complex contributing to the adhesion of two different types of cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]


systematic_name: M26804
exact_source: GO:0086083
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0086083
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]


systematic_name: M18944
exact_source: GO:0090079
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090079
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. [GOC:dph, GOC:tb, GOC:vw]


systematic_name: M34448
exact_source: GO:0090554
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090554
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, RHEA:38583]


systematic_name: M40666
exact_source: GO:0090555
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090555
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, PMID:20043909, RHEA:36440]


systematic_name: M43227
exact_source: GO:0090556
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090556
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [GOC:ab, PMID:16452632, PMID:20224745, RHEA:38567]


systematic_name: M26807
exact_source: GO:0090599
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090599
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose. [GOC:tb]


systematic_name: M26808
exact_source: GO:0097001
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097001
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes. [GOC:sart]


systematic_name: M26810
exact_source: GO:0097100
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097100
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA. [GOC:pr, GOC:rph, PMID:20723754, PMID:21345933, Wikipedia:DNA_supercoil]


systematic_name: M26811
exact_source: GO:0097109
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097109
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation. [GOC:BHF, GOC:pr, GOC:sjp, PMID:21424692]


systematic_name: M18486
exact_source: GO:0097110
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097110
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]


systematic_name: M19216
exact_source: GO:0097153
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097153
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process. [GOC:mtg_apoptosis]


systematic_name: M26813
exact_source: GO:0097199
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097199
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway. [GOC:mtg_apoptosis, PMID:11717445, Wikipedia:Caspase]


systematic_name: M46015
exact_source: GO:0097200
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097200
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis. [GOC:mtg_apoptosis, Wikipedia:Caspase]


systematic_name: M26815
exact_source: GO:0097371
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097371
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the MDM2/MDM4 protein family, comprising negative regulators of p53. [InterPro:IPR016495]


systematic_name: M18704
exact_source: GO:0097472
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097472
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:pr]


systematic_name: M26816
exact_source: GO:0097493
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097493
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling. [GOC:BHF, GOC:rl, PMID:23283722]


systematic_name: M18898
exact_source: GO:0097602
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097602
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3). [GOC:ha, InterPro:IPR016158, PMID:18698375]


systematic_name: M26817
exact_source: GO:0097642
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097642
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity. [GOC:bhm, InterPro:IPR003287, PMID:10871296, PMID:12037140, PMID:18687416]


systematic_name: M26818
exact_source: GO:0097677
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097677
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses. [GOC:mr, InterPro:IPR001217, PMID:21447371, PMID:24470978]


systematic_name: M19144
exact_source: GO:0097747
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097747
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template. [GOC:pf]


systematic_name: M48642
exact_source: GO:0098531
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098531
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific genes and gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors. [GOC:dos, PMID:25568920, PMID:8735275]


systematic_name: M46016
exact_source: GO:0098599
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098599
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of a hydrolase reaction that removes a palmitoyl moiety from some substrate. [GOC:dos, GOC:pg]


systematic_name: M26821
exact_source: GO:0098631
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098631
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding by a cell-adhesion protein on a cell surface to an adhesion molecule on another cell surface or an external substrate, to mediate adhesion of the cell to the external substrate or to another cell. [GOC:vw, Wikipedia:Cell_adhesion]


systematic_name: M40667
exact_source: GO:0098632
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098632
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to another cell. [Wikipedia:Cell_adhesion]


systematic_name: M26823
exact_source: GO:0098634
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098634
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the extracellular matrix. [Wikipedia:Cell_adhesion]


systematic_name: M40668
exact_source: GO:0098809
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098809
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: nitrite + acceptor = product(s) of nitrate reduction + reduced acceptor. [GOC:dos, GOC:jh]


systematic_name: M26827
exact_source: GO:0098821
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098821
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity. [GOC:BHF, GOC:dos]


systematic_name: M26830
exact_source: GO:0098960
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098960
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Neurotransmitter receptor activity occuring in the postsynaptic membrane during synaptic transmission. [GOC:dos, GOC:signaling]


systematic_name: M29508
exact_source: GO:0098973
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098973
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of a postsynaptic actin cytoskeleton. [GOC:dos]


systematic_name: M29509
exact_source: GO:0098988
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098988
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with glutamate and transmitting a signal from one side of the membrane to the other by activating an associated G-protein, initiating a change in cell activity. [GOC:dos]


systematic_name: M26831
exact_source: GO:0099094
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099094
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an inorganic cation by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26832
exact_source: GO:0099095
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099095
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an inorganic anion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26834
exact_source: GO:0099122
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099122
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to the C-terminal domain (CTD) of the largest subunit of RNA polymerase II. The CTD is comprised of repeats of a heptapeptide with the consensus sequence YSPTSPS. The number of repeats varies with the species and a minimum number of repeats is required for RNAP II function. [PMID:20889714]


systematic_name: M46021
exact_source: GO:0099507
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099507
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:15145529, PMID:19558451]


systematic_name: M46022
exact_source: GO:0099508
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099508
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Voltage-gated ion channel activity, occurring in the presynaptic membrane, involved in regulation of presynaptic membrane potential. This is a key step in synaptic transmission, following the arrival of an action potential at the synapse. [GOC:dos]


systematic_name: M17938
exact_source: GO:0099528
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099528
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a neurotransmitter and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:fj, GOC:mah]


systematic_name: M48644
exact_source: GO:0099529
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099529
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Neurotransmitter receptor activity occurring in the postsynaptic membrane that is involved in regulating postsynaptic membrane potential, either directly (ionotropic receptors) or indirectly (e.g. via GPCR activation of an ion channel). [GOC:dos]


systematic_name: M18162
exact_source: GO:0099589
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099589
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the biogenic amine serotonin and transmitting a signal across a membrane by activating some effector activity. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:dos]


systematic_name: M26837
exact_source: GO:0099602
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099602
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function that directly (via physical interaction or direct modification) activates, inhibits or otherwise modulates the activity of a neurotransmitter receptor. Modulation of activity includes changes in desensitization rate, ligand affinity, ion selectivity and pore-opening/closing. [GOC:dos, PMID:12740117, PMID:18387948]


systematic_name: M18509
exact_source: GO:0099604
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099604
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ions by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:dos]


systematic_name: M45371
exact_source: GO:0101005
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0101005
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [GOC:mec, PMID:30783221]


systematic_name: M34450
exact_source: GO:0101021
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0101021
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: estrogen + donor-H2 + O2 = 2-hydroxyestrogen + H2O. [GOC:BHF, GOC:rl, PMID:14559847]


systematic_name: M34451
exact_source: GO:0102545
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0102545
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate. [GOC:pz, MetaCyc:RXN-14899]


systematic_name: M47001
exact_source: GO:0103068
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0103068
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. [GOC:pz, PMID:1676842, PMID:9139674]


systematic_name: M26846
exact_source: GO:0106018
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0106018
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]


systematic_name: M26847
exact_source: GO:0106019
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0106019
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol phosphate + phosphate. [GOC:hjd]


systematic_name: M48645
exact_source: GO:0106029
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0106029
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [PMID:11095668]


systematic_name: M45373
exact_source: GO:0106274
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0106274
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-arginyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide. [RHEA:19149]


systematic_name: M26848
exact_source: GO:0120013
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120013
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes a lipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. This results in intermembrane transfer of lipids. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]


systematic_name: M29512
exact_source: GO:0120014
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120014
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]


systematic_name: M34452
exact_source: GO:0120015
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120015
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes a sterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]


systematic_name: M29513
exact_source: GO:0120016
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120016
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes a sphingolipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]


systematic_name: M40673
exact_source: GO:0120019
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120019
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes phosphatidylcholine from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]


systematic_name: M34453
exact_source: GO:0120146
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120146
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to sulfatide, also known as 3-O-sulfogalactosylceramide, SM4, or sulfated galactocerebroside. Sulfatide is a class of sulfoglycolipid, which are glycolipids that contain a sulfate group. [GOC:krc, PMID:21525289, PMID:22619219, PMID:22977233, PMID:23574804, PMID:29497057, PMID:3549017, Wikipedia:Sulfatide]


systematic_name: M34454
exact_source: GO:0120227
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120227
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an acyl-CoA, a thioester that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of any carboxylic acid. [GOC:krc]


systematic_name: M40674
exact_source: GO:0120250
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120250
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: an omega-methyl fatty acid + O2 + reduced [NADPH--hemoprotein reductase] = an omega-hydroxy fatty acid + H+ + H2O + oxidized [NADPH--hemoprotein reductase]. [GOC:krc, RHEA:39023]


systematic_name: M26850
exact_source: GO:0140035
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140035
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular adaptor that recognizes and binds a target protein containing a ubiquitin-like modification and that brings the target protein into contact with another protein to allow those proteins to function in a coordinated way. [PMID:26060076]


systematic_name: M26851
exact_source: GO:0140078
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140078
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of an AP site 3' of the baseless site by a beta-lyase mechanism, leaving an unsaturated aldehyde, termed a 3'-(4-hydroxy-5-phospho-2-pentenal) residue, and a 5'-phosphate. [PMID:1698278, RHEA:66592]


systematic_name: M26853
exact_source: GO:0140098
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140098
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. [GOC:molecular_function_refactoring, GOC:pdt]


systematic_name: M26855
exact_source: GO:0140102
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140102
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalytic activity that acts to modify a ribosomal RNA. [GOC:molecular_function_refactoring, GOC:pdt]


systematic_name: M26856
exact_source: GO:0140103
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140103
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of a biochemical reaction at physiological temperatures in which one of the substrates is a glycoprotein. [GOC:molecular_function_refactoring, GOC:pdt]


systematic_name: M26857
exact_source: GO:0140104
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140104
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Directly binding to a specific ion or molecule and delivering it either to an acceptor molecule or to a specific location. [GOC:molecular_function_refactoring, GOC:pdt]


systematic_name: M29515
exact_source: GO:0140110
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140110
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons. [GOC:pg, GOC:txnOH-2018, Wikipedia:Transcription_factor]


systematic_name: M48649
exact_source: GO:0140135
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140135
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a monoatomic cation by a channel that opens in response to a mechanical stress. [GOC:ha, PMID:22343900]


systematic_name: M26858
exact_source: GO:0140142
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140142
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to and carrying a cargo between the nucleus and the cytoplasm by moving along with the cargo. The cargo can be either a RNA or a protein. [GOC:pg]


systematic_name: M40676
exact_source: GO:0140161
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140161
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monocarboxylate(out) + Na+(out) = monocarboxylate(in) + Na+(in). [GOC:ln, PMID:15322102]


systematic_name: M26860
exact_source: GO:0140223
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140223
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function required for core promoter activity that mediates the assembly of the RNA polymerase holoenzyme at promoter DNA to form the pre-initiation complex (PIC). General transcription factors (GTFs) bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present at all promoters to initiate transcription. GTFs act at each promoter, although the exact subunit composition at individual promoters may vary. [GOC:txnOH-2018]


systematic_name: M26861
exact_source: GO:0140272
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140272
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein or protein complex from a different species, for example a pathogen molecule binding to a host protein. [PMID:28861068]


systematic_name: M26862
exact_source: GO:0140296
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140296
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. [GOC:txnOH-2018]


systematic_name: M26863
exact_source: GO:0140297
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140297
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA-binding transcription factor, a protein that interacts with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. [GOC:txnOH-2018]


systematic_name: M29516
exact_source: GO:0140299
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140299
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a small molecule and eliciting a change in the protein's activity in response to the intracellular level of that small molecule. [PMID:26328879]


systematic_name: M29517
exact_source: GO:0140303
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140303
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transport of a lipid from a region of a membrane to a different region on the same membrane. [PMID:16828084]


systematic_name: M43234
exact_source: GO:0140311
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140311
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:1493333]


systematic_name: M29518
exact_source: GO:0140312
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140312
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding directly to the structural scaffolding elements of a vesicle coat (such as clathrin or COPII), and bridging the membrane, cargo receptor, and membrane deformation machinery. [PMID:25795254]


systematic_name: M43235
exact_source: GO:0140313
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140313
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a specific molecule to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:13130076]


systematic_name: M40677
exact_source: GO:0140318
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140318
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Directly binding to a specific protein and delivering it to a specific cellular location. [PMID:18706423]


systematic_name: M29520
exact_source: GO:0140326
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140326
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of lipids from one membrane leaflet to the other, driven by ATP hydrolysis. This includes flippases and floppases. [PMID:16828084]


systematic_name: M29521
exact_source: GO:0140327
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140327
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of lipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:20043909, PMID:25284293, Wikipedia:Flippase]


systematic_name: M29522
exact_source: GO:0140328
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140328
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of a lipid from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:20043909, PMID:25284293, Wikipedia:Flippase]


systematic_name: M40678
exact_source: GO:0140333
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140333
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of a glycerophospholipid from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:26212235]


systematic_name: M40679
exact_source: GO:0140345
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140345
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of phosphatidylcholine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:11870854]


systematic_name: M40680
exact_source: GO:0140346
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140346
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of phosphatidylserine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. [PMID:11870854]


systematic_name: M40681
exact_source: GO:0140358
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140358
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Primary active transporter that auto-phosphorylates (hence P) at a key conserved aspartate residue, generating a conformational change that allows transport of the substrate. Hydrolysis of the phosphorylated Asp residue, catalyzed by the actuator (A) domain, results in another state with occluded substrates. Upon dissociation of Mg2+ and Pi, the enzyme reverts to the initial state, in which the counter-transported substrate is released into the cytosol. [PMID:18075584, PMID:25918123]


systematic_name: M40682
exact_source: GO:0140359
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140359
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. [PMID:26517899]


systematic_name: M29523
exact_source: GO:0140375
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140375
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Receiving a signal and transmitting it in a cell to initiate an immune response. [PMID:31415752, Wikipedia:Immune_receptor]


systematic_name: M34456
exact_source: GO:0140410
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140410
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic cation(out) + HCO3-(out) = monoatomic cation(in) + HCO3-(in). [PMID:27166256]


systematic_name: M40683
exact_source: GO:0140416
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140416
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function regulator that inhibits the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:10652346]


systematic_name: M43236
exact_source: GO:0140439
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140439
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740]


systematic_name: M40684
exact_source: GO:0140444
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140444
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together a cytoskeletal protein or protein complex and a nuclear membrane lipid or membrane-associated protein, in order to maintain the localization of the cytoskeleton at a specific location of the nuclear membrane. [PMID:16237665]


systematic_name: M45376
exact_source: GO:0140463
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140463
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together a protein or a protein complex with a nucleosome, to establish or maintain the chromatin localization of the protein, or protein complex. [PMID:32277274]


systematic_name: M47003
exact_source: GO:0140487
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140487
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a metal ion to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active. [PMID:12050156]


systematic_name: M43237
exact_source: GO:0140492
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140492
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An metal-dependent isopeptidase activity that cleaves ubiquitin from a target protein to which it is conjugated. [PMID:19489724]


systematic_name: M47004
exact_source: GO:0140517
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140517
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a protein that brings together another protein and an RNA, permitting those molecules to function in a coordinated way. [PMID:24470144]


systematic_name: M46024
exact_source: GO:0140537
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140537
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function regulator that increases the activity of a transcription regulator via direct binding and/or post-translational modification. [PMID:9597751]


systematic_name: M43238
exact_source: GO:0140545
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140545
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An ATP-dependent molecular chaperone activity that mediates the solubilization of ordered protein aggregates. [PMID:26312418]


systematic_name: M45377
exact_source: GO:0140566
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140566
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A chromatin adaptor that recognizes specific forms of histones, either modified by a post-translational modification, or the unmodified form. Histone readers have roles in many processes, including in centromere function or in modulating the accessibility of cis-regulatory regions to the transcription machinery. [PMID:11498575, PMID:25688442, PMID:31082667, PMID:32260176, PMID:34726351]


systematic_name: M48650
exact_source: GO:0140585
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140585
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Bridging together two cis-regulatory elements, colloquially referred to as promoters and/or enhancers, holding two loop anchors together to maintain a chromatin loop. [PMID:32213323]


systematic_name: M43239
exact_source: GO:0140597
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140597
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to and carrying a protein between two different cellular components by moving along with the target protein. [PMID:7628437]


systematic_name: M45378
exact_source: GO:0140612
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140612
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecule that recognises toxic DNA structures, for example, double-strand breaks or collapsed replication forks, and initiates a signaling response. [PMID:31995034]


systematic_name: M43241
exact_source: GO:0140657
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140657
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function characterized by the coupling of ATP hydrolysis to other steps of a reaction mechanism to make the reaction energetically favorable, for example to catalyze a reaction or drive transport against a concentration gradient. [PMID:24878343, PMID:25750732, PMID:32933017, PMID:33818025, PMID:33873056, PMID:33988324]


systematic_name: M43242
exact_source: GO:0140658
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140658
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An activity, driven by ATP hydrolysis, that modulates the contacts between histones and DNA, resulting in a change in chromosome architecture within the nucleosomal array, leading to chromatin remodeling. [PMID:14729263, PMID:19165147, PMID:21862382, PMID:30867599, PMID:34313222]


systematic_name: M45379
exact_source: GO:0140662
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140662
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein or a protein-containing complex to assist the protein folding process, driven by ATP hydrolysis. [PMID:27365453]


systematic_name: M47005
exact_source: GO:0140664
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140664
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. [PMID:33302090, PMID:33510387]


systematic_name: M18655
exact_source: GO:0140666
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140666
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An activity that facilitates the formation of a complementary double-stranded polynucleotide molecule. [PMID:22888405]


systematic_name: M43243
exact_source: GO:0140677
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140677
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators]


systematic_name: M43244
exact_source: GO:0140678
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140678
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. [GOC:curators]


systematic_name: M43245
exact_source: GO:0140683
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140683
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a di or a monomethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16603238]


systematic_name: M43246
exact_source: GO:0140684
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140684
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20208542, PMID:20531378]


systematic_name: M45380
exact_source: GO:0140693
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140693
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding and bringing together two or more macromolecules in contact, permitting those molecules to organize as a molecular condensate. [PMID:28225081]


systematic_name: M45381
exact_source: GO:0140713
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140713
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to and carrying a histone or a histone complex to unload or deposit it as a nucleosome. The histone can be newly synthesized or result from nucleosome disassembly (either spontaneously, or by a histone chaperone). [PMID:26459557]


systematic_name: M45382
exact_source: GO:0140767
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140767
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An adaptor that brings together an enzyme and its substrate. Adaptors recruit the substrate to its enzyme, thus contributing to substrate selection and specificity. [PMID:16250895, PMID:34358446]


systematic_name: M45383
exact_source: GO:0140776
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140776
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function that involves direct binding to one of the subunits of a protein-containing complex and promoting the dissociation of one or many subunits. This often happens by changing the conformation of the protein being bound, which decreases its affinity for the rest of the complex. [PMID:23727094, PMID:29779865, PMID:34836783]


systematic_name: M47006
exact_source: GO:0140784
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140784
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to and responding, e.g. by conformational change, to changes in the cellular level of a metal ion. [GOC:pg]


systematic_name: M45384
exact_source: GO:0140803
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140803
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-cysteinyl-[protein] + NAD+ = H+ + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein]. [PMID:25043379, RHEA:56612]


systematic_name: M45385
exact_source: GO:0140804
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140804
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl-[protein] + NAD+ = H+ + N(6)-(ADP-D-ribosyl)-L-lysyl-[protein] + nicotinamide. [PMID:25043379, RHEA:58220]


systematic_name: M45386
exact_source: GO:0140806
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140806
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-aspartyl-[protein] + NAD+ = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide. [PMID:19764761, PMID:25043379, RHEA:54424]


systematic_name: M46026
exact_source: GO:0140824
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140824
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: [thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O. [PMID:12707274, PMID:19820102, RHEA:62620]


systematic_name: M45387
exact_source: GO:0140828
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140828
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(in) = solute(in) + Na+(out). [GOC:pg]


systematic_name: M46027
exact_source: GO:0140829
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140829
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(in) + HCO3-(out) = solute(out) + HCO3-(in). [PMID:12440690]


systematic_name: M46028
exact_source: GO:0140848
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140848
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + monoatomic cation(in) = solute(in) + monoatomic cation(out). Monoatomic cations include H+, Mg2+, Ca2+, etc. [GOC:curators]


systematic_name: M47008
exact_source: GO:0140869
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140869
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Stops, prevents or reduces the activity of miRNA-mediated gene silencing activity by base-pairing with a target miRNA. An example of this activity is mediated by long non-coding RNAs (lncRNAs). [PMID:34454184]


systematic_name: M48653
exact_source: GO:0140933
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140933
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 5'-end (N7-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + N7-methyl-GDP + H+. [PMID:18820299, PMID:29483298]


systematic_name: M47009
exact_source: GO:0140934
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140934
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A deubiquitinase that cleaves ubiquitin from a histone protein to which it is conjugated. [PMID:18206972, PMID:18226187]


systematic_name: M46029
exact_source: GO:0140938
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140938
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + a histone H3 = S-adenosyl-L-homocysteine + a methylated histone H3. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737]


systematic_name: M46030
exact_source: GO:0140939
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140939
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: Catalysis of the reaction: S-adenosyl-L-methionine + a histone H4 = S-adenosyl-L-homocysteine + a methylated histone H4. Histone methylation generally occurs on either an arginine or a lysine residue. [PMID:28450737]


systematic_name: M46031
exact_source: GO:0140944
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140944
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl20-[histone H4] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl20-[histone H4] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 20 of histone H4, producing histone H4K20me. [RHEA:60344]


systematic_name: M46032
exact_source: GO:0140945
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140945
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl4-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me. [RHEA:60264]


systematic_name: M46033
exact_source: GO:0140947
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140947
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: N6,N6-dimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a single methyl group to the dimethylated lysine residue at position 9 of histone H3, producing histone H3K9me3. [RHEA:60280]


systematic_name: M46034
exact_source: GO:0140948
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140948
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl9-[histone H3] + S-adenosyl-L-methionine = H+ + N6-methyl-L-lysyl9-[histone H3] + S-adenosyl-L-homocysteine. This reaction is the addition of a methyl group to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me. [RHEA:60288]


systematic_name: M47010
exact_source: GO:0140949
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140949
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl9-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl9-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 9 of histone H3, producing histone H3K9me3. [RHEA:60276]


systematic_name: M48654
exact_source: GO:0140950
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140950
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A histone deubiquitinase that cleaves ubiquitin from a histone H2A protein to which it is conjugated. [PMID:18226187, PMID:20436459]


systematic_name: M47011
exact_source: GO:0140955
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140955
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl36-[histone H3] + 3 S-adenosyl-L-methionine = 3 H+ + N6,N6,N6-trimethyl-L-lysyl36-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the lysine residue at position 36 of histone H3, producing histone H3K36me3. [RHEA:60324]


systematic_name: M47012
exact_source: GO:0140993
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140993
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A catalytic activity that acts on a histone protein. Reversible histone modifications contribute to regulation of gene expression. [GOC:pg]


systematic_name: M47013
exact_source: GO:0140994
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140994
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A catalytic activity that acts on the RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS). Reversible modifications cof the RNA polymerase II CTD repeats contribute to regulation of RNA polymerase activity. [GOC:pg]


systematic_name: M47015
exact_source: GO:0140999
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140999
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-lysyl4-[histone H3] + 3 S-adenosyl-L-methionine = 2 H+ + N6,N6-trimethyl-L-lysyl4-[histone H3] + 3 S-adenosyl-L-homocysteine. This reaction is the successive addition of three methyl groups to the unmethylated lysine residue at position 4 of histone H3, producing histone H3K4me3. [PMID:18375658, RHEA:60260]


systematic_name: M47016
exact_source: GO:0141047
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0141047
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another molecule (for example a protein or a lipid) where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation. [PMID:17632063]


systematic_name: M47018
exact_source: GO:0141058
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0141058
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the removal of a methyl group from a modified lysine residue of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:17947579]


systematic_name: M47020
exact_source: GO:0160009
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0160009
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: H2O + N6-(2E)-butenoyl-L-lysyl-[histone] = (2E)-2-butenoate + L-lysyl-[histone]. [PMID:28497810]


systematic_name: M47021
exact_source: GO:0160041
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0160041
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The receptor ligand activity of any polypeptide expressed in, and secreted from a neuron. [PMID:18806786, PMID:21922398]


systematic_name: M47022
exact_source: GO:0160072
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0160072
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together an ubiquitin ligase and an ubiquitin ligase-substrate adaptor, permitting those molecules to function in a coordinated way. [PMID:27664236]


systematic_name: M26864
exact_source: GO:1901474
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1901474
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, from one side of a membrane to the other. [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]


systematic_name: M43247
exact_source: GO:1901480
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1901480
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of oleate from one side of a membrane to the other. [GOC:TermGenie, PMID:19493158, RHEA:33655]


systematic_name: M26865
exact_source: GO:1901505
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1901505
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of carbohydrate derivative from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]


systematic_name: M18137
exact_source: GO:1901618
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1901618
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of organic hydroxy compound from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]


systematic_name: M17921
exact_source: GO:1901682
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1901682
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a sulfur compound from one side of a membrane to the other. [GOC:pr, GOC:TermGenie]


systematic_name: M26869
exact_source: GO:1902282
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902282
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a ventricular cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:8528244]


systematic_name: M40685
exact_source: GO:1902388
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902388
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes a ceramide 1-phosphate from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:TermGenie, PMID:23863933]


systematic_name: M18543
exact_source: GO:1902936
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902936
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol bisphosphate. [GO_REF:0000067, GOC:bhm, GOC:TermGenie, PMID:18690034]


systematic_name: M46035
exact_source: GO:1903135
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1903135
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a cupric ion, copper(2+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]


systematic_name: M26871
exact_source: GO:1903136
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1903136
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a cuprous ion, copper(1+). [GO_REF:0000067, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24567322]


systematic_name: M29525
exact_source: GO:1903763
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1903763
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any gap junction channel activity that is involved in cell communication by electrical coupling. [GO_REF:0000061, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:24587307]


systematic_name: M26873
exact_source: GO:1904047
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1904047
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to S-adenosyl-L-methionine. [GO_REF:0000067, GOC:BHF, GOC:hal, GOC:TermGenie, PMID:22985361]


systematic_name: M26874
exact_source: GO:1904680
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1904680
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a peptide from one side of a membrane to the other. [GO_REF:0000070, GOC:TermGenie, GOC:vw]


systematic_name: M26877
exact_source: GO:1990050
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990050
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes a phosphatidic acid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. Phosphatidic acid refers to a glycophospholipids with, in general, a saturated fatty acid bonded to carbon-1, an unsaturated fatty acid bonded to carbon-2, and a phosphate group bonded to carbon-3. [PMID:23042293]


systematic_name: M26880
exact_source: GO:1990247
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990247
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein adaptor that recognizes and binds an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs. [PMID:22575960, PMID:24284625]


systematic_name: M26881
exact_source: GO:1990254
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990254
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. [GOC:krc, PMID:6170061]


systematic_name: M26882
exact_source: GO:1990380
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990380
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Hydrolysis of a ubiquitin unit from a ubiquitinated protein linked via the Lys48 residue of ubiquitin. [GOC:bf, GOC:PARL, PMID:22970133]


systematic_name: M46036
exact_source: GO:1990404
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990404
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: amino acyl-[protein] + NAD+ = H+ + (ADP-D-ribosyl)-amino acyl-[protein] + nicotinamide. [PMID:1899243]


systematic_name: M47024
exact_source: GO:1990756
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990756
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together a ubiquitin-like ligase (including ubiquitin ligase and UFM1 ligase) and its substrate. Usually mediated by F-box BTB/POZ domain proteins. [PMID:24658274]


systematic_name: M26889
exact_source: GO:1990763
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990763
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors. [PMID:23911909]


systematic_name: M43249
exact_source: GO:1990814
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990814
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An activity that faciliates the formation of a complementary double-stranded DNA molecule. [PMID:22888405, PMID:25520186]


systematic_name: M26890
exact_source: GO:1990817
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990817
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide. The primer may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group. [PMID:13965521, RHEA:11332]


systematic_name: M26891
exact_source: GO:1990825
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990825
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif. [PMID:11886857]


systematic_name: M26893
exact_source: GO:1990841
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990841
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a section of chromatin that is associated with gene promoter sequences of DNA. [PMID:19948729]


systematic_name: M45390
exact_source: GO:1990935
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990935
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein involved in the process of removing sections of the primary RNA transcript to form the mature form of the RNA. [PMID:11118435]


systematic_name: M47025
exact_source: GO:1990948
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990948
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a ubiquitin ligase. [GOC:dph, GOC:vw, PMID:21389117]


systematic_name: M5895
source_species_code: HS
contributor: Arthur Liberzon
contrib_organization: MSigDB Team
description_brief:
  Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499].


systematic_name: M5916
source_species_code: HS
contributor: Arthur Liberzon
contrib_organization: MSigDB Team
description_brief:
  Genes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area).


systematic_name: M5922
source_species_code: HS
contributor: Arthur Liberzon
contrib_organization: MSigDB Team
description_brief:
  Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum.


systematic_name: M5945
source_species_code: HS
contributor: Arthur Liberzon
contrib_organization: MSigDB Team
description_brief:
  Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation.


description_brief: Multicystic kidney dysplasia
systematic_name: M34476
exact_source: HP:0000003
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000003
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Multicystic dysplasia of the kidney is characterized by multiple cysts of varying size in the kidney and the absence of a normal pelvicaliceal system. The condition is associated with ureteral or ureteropelvic atresia, and the affected kidney is nonfunctional. [https://orcid.org/0000-0002-0736-9199]


description_brief: Neurogenic bladder
systematic_name: M34478
exact_source: HP:0000011
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000011
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A type of bladder dysfunction caused by neurologic damage. Neurogenic bladder can be flaccid or spastic. Common manifestatios of neurogenic bladder are overflow incontinence, frequency, urgency, urge incontinence, and retention. [https://orcid.org/0000-0002-0736-9199, PMID:18095004, PMID:22400020]


description_brief: Urinary urgency
systematic_name: M34479
exact_source: HP:0000012
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000012
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Urge incontinence is the strong, sudden need to urinate. [https://orcid.org/0000-0002-0736-9199, PMID:12559262]


description_brief: Bladder diverticulum
systematic_name: M34482
exact_source: HP:0000015
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000015
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Diverticulum (sac or pouch) in the wall of the urinary bladder. [https://orcid.org/0000-0002-0736-9199]


description_brief: Urinary retention
systematic_name: M34483
exact_source: HP:0000016
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000016
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Inability to completely empty the urinary bladder during the process of urination. [https://orcid.org/0000-0002-0736-9199]


description_brief: Nocturia
systematic_name: M34484
exact_source: HP:0000017
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000017
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormally increased production of urine during the night leading to an unusually frequent need to urinate. [https://orcid.org/0009-0006-4530-3154]


description_brief: Urinary incontinence
systematic_name: M41211
exact_source: HP:0000020
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000020
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Loss of the ability to control the urinary bladder leading to involuntary urination. [https://orcid.org/0009-0006-4530-3154, PMID:12559262]


description_brief: Inguinal hernia
systematic_name: M34486
exact_source: HP:0000023
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000023
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Protrusion of the contents of the abdominal cavity through the inguinal canal. [https://orcid.org/0000-0002-0736-9199]


description_brief: Male hypogonadism
systematic_name: M34489
exact_source: HP:0000026
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000026
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Decreased functionality of the male gonad, i.e., of the testis, with reduced spermatogenesis or testosterone synthesis. [https://orcid.org/0000-0002-0736-9199]


description_brief: Azoospermia
systematic_name: M48669
exact_source: HP:0000027
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000027
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Absence of any measurable level of sperm,whereby spermatozoa cannot be observed even after centrifugation of the semen pellet. [https://orcid.org/0000-0002-0736-9199, PMID:20514278]


description_brief: Cryptorchidism
systematic_name: M34490
exact_source: HP:0000028
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000028
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Testis in inguinal canal. That is, absence of one or both testes from the scrotum owing to failure of the testis or testes to descend through the inguinal canal to the scrotum. [https://orcid.org/0000-0002-0736-9199, PMID:23650202]


description_brief: Testicular atrophy
systematic_name: M34491
exact_source: HP:0000029
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000029
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Wasting (atrophy) of the testicle (the male gonad) manifested by a decrease in size and potentially by a loss of fertility. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ambiguous genitalia, male
systematic_name: M34492
exact_source: HP:0000033
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000033
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Ambiguous genitalia in an individual with XY genetic gender. [https://orcid.org/0000-0002-0736-9199]


description_brief: Hydrocele testis
systematic_name: M34493
exact_source: HP:0000034
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000034
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Accumulation of clear fluid in the between the layers of membrane (tunica vaginalis) surrounding the testis. [PMID:32644551]


description_brief: Male pseudohermaphroditism
systematic_name: M34496
exact_source: HP:0000037
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000037
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Hermaphroditism refers to a discrepancy between the morphology of the gonads and that of the external genitalia. In male pseudohermaphroditism, the genotype is male (XY) and the external genitalia are imcompletely virilized, ambiguous, or complete female. If gonads are present, they are testes. [https://orcid.org/0000-0002-0736-9199]


description_brief: Epispadias
systematic_name: M34497
exact_source: HP:0000039
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000039
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Epispadias is a urogenital malformation characterized by the failure of the urethral tube to tubularize on the dorsal aspect. Unlike in hypospadias, where the meatus is on the ventral aspect, children with epispadias have a wide-open urethral plate on the dorsum. It is commonly seen as a component in the spectrum of bladder exstrophy-epispadias-complex. Isolated epispadias constitutes less than 10 percent of the total cases of epispadias. [https://orcid.org/0000-0002-0736-9199, PMID:23650202, PMID:33085327]


description_brief: Chordee
systematic_name: M34499
exact_source: HP:0000041
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000041
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Ventral, lateral, or ventrolateral bowing of the shaft and glans penis of more than 30 degrees. [https://orcid.org/0000-0002-0736-9199, PMID:23650202]


description_brief: Hypogonadotropic hypogonadism
systematic_name: M34500
exact_source: HP:0000044
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000044
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH). [https://orcid.org/0000-0002-0736-9199, PMID:23503957]


description_brief: Abnormal scrotum morphology
systematic_name: M34501
exact_source: HP:0000045
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000045
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any structural abnormality of the scrotum, i.e., the sac that contains the testes, epididymis, and the lower part of the spermatic cord. []


description_brief: Shawl scrotum
systematic_name: M34504
exact_source: HP:0000049
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000049
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Superior margin of the scrotum superior to the base of the penis. [https://orcid.org/0000-0002-0736-9199, PMID:23650202]


description_brief: Perineal hypospadias
systematic_name: M47026
exact_source: HP:0000051
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000051
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Hypospadias with location of the urethral meatus in the perineal region. [https://orcid.org/0000-0002-0736-9199, PMID:8097257]


description_brief: Micropenis
systematic_name: M34507
exact_source: HP:0000054
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000054
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormally small penis. At birth, the normal penis is about 3 cm (stretched length from pubic tubercle to tip of penis) with micropenis less than 2.0-2.5 cm. [https://orcid.org/0000-0002-0736-9199, PMID:15102623]


description_brief: Abnormal female external genitalia morphology
systematic_name: M34508
exact_source: HP:0000055
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000055
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any structural abnormality of the female external genitalia. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal labia morphology
systematic_name: M34510
exact_source: HP:0000058
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000058
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly of the labia, the externally visible portions of the vulva. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ambiguous genitalia, female
systematic_name: M34512
exact_source: HP:0000061
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000061
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Ambiguous genitalia in an individual with XX genetic gender. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ambiguous genitalia
systematic_name: M34513
exact_source: HP:0000062
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000062
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A genital phenotype that is not clearly assignable to a single gender. Ambiguous genitalia can be evaluated using the Prader scale: Prader 0: Normal female external genitalia. Prader 1: Female external genitalia with clitoromegaly. Prader 2: Clitoromegaly with partial labial fusion forming a funnel-shaped urogenital sinus. Prader 3: Increased phallic enlargement. Complete labioscrotal fusion forming a urogenital sinus with a single opening. Prader 4: Complete scrotal fusion with urogenital opening at the base or on the shaft of the phallus. Prader 5: Normal male external genitalia. The diagnosis of ambiguous genitalia is made for Prader 1-4. [https://orcid.org/0000-0002-0736-9199, PMID:15102623]


description_brief: Urethral atresia
systematic_name: M34517
exact_source: HP:0000068
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000068
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Congenital anomaly characterized by closure or failure to develop an opening in the urethra. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of the ureter
systematic_name: M34518
exact_source: HP:0000069
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000069
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the ureter. The ureter is the duct by which urine passes from the kidney to the bladder. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ureterocele
systematic_name: M34519
exact_source: HP:0000070
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000070
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A ureterocele is a congenital saccular dilatation of the distal segment of the ureter. [eMedicine:453993]


description_brief: Ureteral duplication
systematic_name: M34521
exact_source: HP:0000073
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000073
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A developmental anomaly characterized by the presence of two, instead of one, ureter connecting a kidney to the bladder. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ureteropelvic junction obstruction
systematic_name: M34522
exact_source: HP:0000074
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000074
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Blockage of urine flow from the renal pelvis to the proximal ureter. [HPO_CONTRIBUTOR:Eurenomics_ewuehl]


description_brief: Renal duplication
systematic_name: M34523
exact_source: HP:0000075
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000075
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A congenital anomaly of the urinary tract, in which the kidney is duplicated and is drained via two separate renal pelves and ureters. [https://orcid.org/0000-0002-0736-9199]


description_brief: Duplicated collecting system
systematic_name: M34525
exact_source: HP:0000081
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000081
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A duplication of the collecting system of the kidney, defined as a kidney with two (instead of, normally, one) pyelocaliceal systems. The pyelocaliceal system is comprised of the renal pelvis and calices. The duplicated renal collecting system can be associated with a single ureter or with double ureters. In the latter case, the two ureters empty separately into the bladder or fuse to form a single ureteral orifice. [https://orcid.org/0000-0002-0736-9199]


description_brief: Renal insufficiency
systematic_name: M34526
exact_source: HP:0000083
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000083
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism. [https://orcid.org/0000-0002-0736-9199]


description_brief: Horseshoe kidney
systematic_name: M34527
exact_source: HP:0000085
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000085
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A connection of the right and left kidney by an isthmus of functioning renal parenchyma or fibrous tissue that crosses the midline. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ectopic kidney
systematic_name: M34528
exact_source: HP:0000086
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000086
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A developmental defect in which a kidney is located in an abnormal anatomic position. [https://orcid.org/0000-0002-0736-9199]


description_brief: Nephronophthisis
systematic_name: M34530
exact_source: HP:0000090
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000090
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Presence of cysts at the corticomedullary junction of the kidney in combination with tubulointerstitial fibrosis. [HPO_CONTRIBUTOR:Eurenomics_fschaefer]


description_brief: Renal tubular atrophy
systematic_name: M48672
exact_source: HP:0000092
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000092
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of renal tubules with thick redundant basement membranes, or a reduction of greater than 50% in tubular diameter compared to surrounding non-atrophic tubules. [https://orcid.org/0000-0002-0736-9199, PMID:27211375]


description_brief: Focal segmental glomerulosclerosis
systematic_name: M34534
exact_source: HP:0000097
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000097
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Segmental accumulation of scar tissue in individual (but not all) glomeruli. [HPO_CONTRIBUTOR:Eurenomics_fschaefer, PMID:16164633]


description_brief: Tall stature
systematic_name: M34535
exact_source: HP:0000098
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000098
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A height above that which is expected according to age and gender norms. [https://orcid.org/0000-0002-0736-9199]


description_brief: Nephrotic syndrome
systematic_name: M34537
exact_source: HP:0000100
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000100
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria. Nephrotic syndrome refers to the constellation of clinical findings that result from severe renal loss of protein, with Proteinuria and hypoalbuminemia, edema, and hyperlipidemia. [https://orcid.org/0000-0002-0736-9199]


description_brief: Renal agenesis
systematic_name: M34539
exact_source: HP:0000104
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000104
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Agenesis, that is, failure of the kidney to develop during embryogenesis and development. [https://orcid.org/0000-0002-0736-9199]


description_brief: Renal corticomedullary cysts
systematic_name: M34542
exact_source: HP:0000108
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000108
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of multiple cysts at the border between the renal cortex and medulla. [https://orcid.org/0000-0002-0736-9199]


description_brief: Nephropathy
systematic_name: M34544
exact_source: HP:0000112
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000112
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A nonspecific term referring to disease or damage of the kidneys. [https://orcid.org/0000-0002-0736-9199]


description_brief: Proximal tubulopathy
systematic_name: M34546
exact_source: HP:0000114
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000114
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Dysfunction of the proximal tubule, which is the portion of the duct system of the nephron of the kidney which leads from Bowman's capsule to the loop of Henle. [https://orcid.org/0000-0002-0736-9199]


description_brief: Nephrocalcinosis
systematic_name: M34548
exact_source: HP:0000121
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000121
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Nephrocalcinosis is the deposition of calcium salts in renal parenchyma. [https://orcid.org/0000-0002-0736-9199]


description_brief: Renal tubular dysfunction
systematic_name: M34551
exact_source: HP:0000124
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000124
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormal function of the renal tubule. The basic functional unit of the kidney, the nephron, consists of a renal corpuscle attached to a renal tubule, with roughly 0.8 to 1.5 nephrons per adult kidney. The functions of the renal tubule include reabsorption of water, electrolytes, glucose, and amino acids and secretion of substances such as uric acid. []


description_brief: Pelvic kidney
systematic_name: M34552
exact_source: HP:0000125
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000125
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A developmental defect in which a kidney is located in an abnormal anatomic position within the pelvis. [https://orcid.org/0000-0002-0736-9199]


description_brief: Renal salt wasting
systematic_name: M34553
exact_source: HP:0000127
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000127
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A high concentration of one or more electrolytes in the urine in the presence of low serum concentrations of the electrolyte(s). [HPO_CONTRIBUTOR:Eurenomics_fschaefer]


description_brief: Menorrhagia
systematic_name: M34556
exact_source: HP:0000132
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000132
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Prolonged and excessive menses at regular intervals in excess of 80 mL or lasting longer than 7 days. [https://orcid.org/0000-0002-0736-9199, PMID:22594864]


description_brief: Female hypogonadism
systematic_name: M34558
exact_source: HP:0000134
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000134
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Decreased functionality of the female gonads, i.e., of the ovary. [https://orcid.org/0000-0002-0736-9199]


description_brief: Amenorrhea
systematic_name: M34564
exact_source: HP:0000141
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000141
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Absence of menses for an interval of time equivalent to a total of more than (or equal to) 3 previous cycles or 6 months. [PMID:22594864]


description_brief: Rectovaginal fistula
systematic_name: M46052
exact_source: HP:0000143
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000143
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of a fistula between the vagina and the rectum. [https://orcid.org/0000-0002-0736-9199]


description_brief: Vaginal atresia
systematic_name: M48673
exact_source: HP:0000148
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000148
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Congenital occlusion of the vagina or adhesion of the walls of the vagina causing occlusion. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ovarian gonadoblastoma
systematic_name: M34568
exact_source: HP:0000149
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000149
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of a gonadoblastoma of the ovary. [eMedicine:986581, https://orcid.org/0000-0002-0736-9199]


description_brief: Gonadoblastoma
systematic_name: M34569
exact_source: HP:0000150
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000150
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of a gonadoblastoma, a neoplasm of a gonad that consists of aggregates of germ cells and sex cord elements. [https://orcid.org/0000-0002-0736-9199]


description_brief: Wide mouth
systematic_name: M34571
exact_source: HP:0000154
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000154
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between the oral commissures more than 2 SD above the mean. Alternatively, an apparently increased width of the oral aperture (subjective). [PMID:19125428]


description_brief: Oral ulcer
systematic_name: M34572
exact_source: HP:0000155
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000155
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Erosion of the mucous mebrane of the mouth with local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. [https://orcid.org/0000-0002-0736-9199]


description_brief: Narrow mouth
systematic_name: M34576
exact_source: HP:0000160
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000160
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between the commissures of the mouth more than 2 SD below the mean. Alternatively, an apparently decreased width of the oral aperture (subjective). [PMID:19125428]


description_brief: Median cleft upper lip
systematic_name: M34577
exact_source: HP:0000161
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000161
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A type of cleft lip presenting as a midline (median) gap in the upper lip. [https://orcid.org/0000-0002-0736-9199]


description_brief: Glossoptosis
systematic_name: M34578
exact_source: HP:0000162
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000162
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Posterior displacement of the tongue into the pharynx, i.e., a tongue that is mislocalised posteriorly. [https://orcid.org/0000-0002-0736-9199, PMID:19125428]


description_brief: Abnormal uvula morphology
systematic_name: M34583
exact_source: HP:0000172
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000172
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormality of the uvula, the conic projection from the posterior edge of the middle of the soft palate. [https://orcid.org/0000-0002-0736-9199]


description_brief: Cleft palate
systematic_name: M48674
exact_source: HP:0000175
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000175
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Cleft palate is a developmental defect of the palate resulting from a failure of fusion of the palatine processes and manifesting as a separation of the roof of the mouth (soft and hard palate). [https://orcid.org/0000-0002-0736-9199]


description_brief: Thick lower lip vermilion
systematic_name: M34588
exact_source: HP:0000179
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000179
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Increased thickness of the lower lip, leading to a prominent appearance of the lower lip. The height of the vermilion of the lower lip in the midline is more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the lower lip in the frontal view (subjective). [https://orcid.org/0000-0002-0736-9199, PMID:19125428]


description_brief: Lobulated tongue
systematic_name: M34589
exact_source: HP:0000180
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000180
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Multiple indentations and/or elevations on the edge and/or surface of the tongue producing an irregular surface contour. [PMID:19125428]


description_brief: Cleft soft palate
systematic_name: M34592
exact_source: HP:0000185
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000185
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Cleft of the soft palate (also known as the velum, or muscular palate) as a result of a developmental defect occurring between the 7th and 12th week of pregnancy. Cleft soft palate can cause functional abnormalities of the Eustachian tube with resulting middle ear anomalies and hearing difficulties, as well as speech problems associated with hypernasal speech due to velopharyngeal insufficiency. [https://orcid.org/0000-0002-0736-9199]


description_brief: Narrow palate
systematic_name: M34595
exact_source: HP:0000189
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000189
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Width of the palate more than 2 SD below the mean (objective) or apparently decreased palatal width (subjective). [PMID:19125428]


description_brief: Abnormal oral frenulum morphology
systematic_name: M34596
exact_source: HP:0000190
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000190
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the lingual frenulum, that is of the small fold of mucous membrane that attaches the tongue to the floor of the mouth, or the presence of accessory frenula in the oral cavity. [https://orcid.org/0000-0002-0736-9199, PMID:23633765]


description_brief: Accessory oral frenulum
systematic_name: M34597
exact_source: HP:0000191
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000191
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Extra fold of tissue extending from the alveolar ridge to the inner surface of the upper or lower lip. [PMID:19125428]


description_brief: Open mouth
systematic_name: M34598
exact_source: HP:0000194
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000194
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A facial appearance characterized by a permanently or nearly permanently opened mouth. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal parotid gland morphology
systematic_name: M34599
exact_source: HP:0000197
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000197
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any abnormality of the parotid glands, which are the salivary glands that are located in the subcutaneous tissues of the face overlying the mandibular ramus and anterior and inferior to the external ear. [https://orcid.org/0000-0002-0736-9199]


description_brief: Pierre-Robin sequence
systematic_name: M34602
exact_source: HP:0000201
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000201
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Pierre Robin malformation is a sequence of developmental malformations characterized by micrognathia (mandibular hypoplasia), glossoptosis and cleft palate. [https://orcid.org/0000-0002-0736-9199]


description_brief: Cleft upper lip
systematic_name: M41218
exact_source: HP:0000204
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000204
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A gap or groove in the upper lip. This is a congenital defect resulting from nonfusion of tissues of the lip during embryonal development. [https://orcid.org/0000-0002-0736-9199]


description_brief: Pursed lips
systematic_name: M43252
exact_source: HP:0000205
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000205
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the appearance of the face caused by constant contraction of the lips leading to a puckered or pursed appearance. [https://orcid.org/0000-0002-0736-9199]


description_brief: Gingival overgrowth
systematic_name: M34607
exact_source: HP:0000212
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000212
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Hyperplasia of the gingiva (that is, a thickening of the soft tissue overlying the alveolar ridge. The degree of thickening ranges from involvement of the interdental papillae alone to gingival overgrowth covering the entire tooth crown. [PMID:19125428]


description_brief: Lip telangiectasia
systematic_name: M48675
exact_source: HP:0000214
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000214
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Telangiectasia (that is, the presence of small dilated superficial blood vessels) of the lips. [https://orcid.org/0000-0002-0736-9199]


description_brief: Thick upper lip vermilion
systematic_name: M34608
exact_source: HP:0000215
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000215
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Height of the vermilion of the upper lip in the midline more than 2 SD above the mean. Alternatively, an apparently increased height of the vermilion of the upper lip in the frontal view (subjective). [PMID:19125428]


description_brief: High palate
systematic_name: M34610
exact_source: HP:0000218
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000218
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Height of the palate more than 2 SD above the mean (objective) or palatal height at the level of the first permanent molar more than twice the height of the teeth (subjective). [PMID:19125428]


description_brief: Thin upper lip vermilion
systematic_name: M34611
exact_source: HP:0000219
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000219
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Height of the vermilion of the upper lip in the midline more than 2 SD below the mean. Alternatively, an apparently reduced height of the vermilion of the upper lip in the frontal view (subjective). [PMID:19125428]


description_brief: Velopharyngeal insufficiency
systematic_name: M34612
exact_source: HP:0000220
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000220
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Inability of velopharyngeal sphincter to sufficiently separate the nasal cavity from the oral cavity during speech. [HPO_CONTRIBUTOR:DDD_jhurst]


description_brief: Everted lower lip vermilion
systematic_name: M46053
exact_source: HP:0000232
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000232
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormal configuration of the lower lip such that it is turned outward i.e., everted, with the Inner aspect of the lower lip vermilion (normally opposing the teeth) being visible in a frontal view. [PMID:19125428]


description_brief: Thin vermilion border
systematic_name: M34617
exact_source: HP:0000233
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000233
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Height of the vermilion of the medial part of the lip more than 2 SD below the mean, or apparently reduced height of the vermilion of the lip in the frontal view. The vermilion is the red part of the lips (and confusingly, the vermilion itself is also often referred to as being equivalent the lips). [https://orcid.org/0000-0002-0736-9199, PMID:19125428]


description_brief: Abnormality of the fontanelles or cranial sutures
systematic_name: M34618
exact_source: HP:0000235
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000235
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any abnormality of the fontanelles (the regions covered by a thick membrane that normally ossify in the first two years of life) or the cranial sutures (the fibrous joints in which the articulating bones or cartilages of the skull are connected by sutural ligaments). [https://orcid.org/0000-0002-0736-9199, PMID:12825844]


description_brief: Abnormality of the anterior fontanelle
systematic_name: M34619
exact_source: HP:0000236
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000236
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the anterior fontanelle, i.e., the cranial fontanelle that is located at the intersection of the coronal and sagittal sutures. [https://orcid.org/0000-0002-0736-9199]


description_brief: Small anterior fontanelle
systematic_name: M34620
exact_source: HP:0000237
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000237
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormally decreased size of the anterior fontanelle with respect to age-dependent norms. [https://orcid.org/0000-0002-0736-9199]


description_brief: Hydrocephalus
systematic_name: M34621
exact_source: HP:0000238
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000238
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Hydrocephalus is an active distension of the ventricular system of the brain resulting from inadequate passage of CSF from its point of production within the cerebral ventricles to its point of absorption into the systemic circulation. [https://orcid.org/0000-0002-0736-9199, PMID:18211712, PMID:19410151]


description_brief: Large fontanelles
systematic_name: M46054
exact_source: HP:0000239
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000239
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  In newborns, the two frontal bones, two parietal bones, and one occipital bone are joined by fibrous sutures, which form a small posterior fontanelle, and a larger, diamond-shaped anterior fontanelle. These regions allow for the skull to pass the birth canal and for later growth. The fontanelles gradually ossify, whereby the posterior fontanelle usually closes by eight weeks and the anterior fontanelle by the 9th to 16th month of age. Large fontanelles are diagnosed if the fontanelles are larger than age-dependent norms. [https://orcid.org/0000-0002-0736-9199]


description_brief: Parietal bossing
systematic_name: M34623
exact_source: HP:0000242
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000242
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Parietal bossing is a marked prominence in the parietal region. [https://orcid.org/0000-0002-0736-9199]


description_brief: Trigonocephaly
systematic_name: M34624
exact_source: HP:0000243
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000243
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Wedge-shaped, or triangular head, with the apex of the triangle at the midline of the forehead and the base of the triangle at the occiput. [PMID:19125436]


description_brief: Brachyturricephaly
systematic_name: M34625
exact_source: HP:0000244
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000244
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormal vertical height of the skull and a shortening of its anterior-posterior length, frequently combined with malformations of the occipital region. [PMID:8460563]


description_brief: Abnormal paranasal sinus morphology
systematic_name: M34626
exact_source: HP:0000245
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000245
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormality of the paranasal (cranial) sinuses, which are air-filled spaces that are located within the bones of the skull and face and communicate with the nasal cavity. They comprise the maxillary sinuses, the frontal sinuses, the ethmoid sinuses, and the sphenoid sinuses. [https://orcid.org/0000-0002-0736-9199]


description_brief: Brachycephaly
systematic_name: M34627
exact_source: HP:0000248
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000248
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of skull shape characterized by a decreased anterior-posterior diameter. That is, a cephalic index greater than 81%. Alternatively, an apparently shortened anteroposterior dimension (length) of the head compared to width. [https://orcid.org/0000-0002-0736-9199, PMID:19125436]


description_brief: Progressive microcephaly
systematic_name: M34628
exact_source: HP:0000253
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000253
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Progressive microcephaly is diagnosed when the head circumference falls progressively behind age- and gender-dependent norms. [https://orcid.org/0000-0002-0736-9199]


description_brief: Macrocephaly
systematic_name: M48676
exact_source: HP:0000256
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000256
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Occipitofrontal (head) circumference greater than 97th centile compared to appropriate, age matched, sex-matched normal standards. Alternatively, a apparently increased size of the cranium. [PMID:19125436]


description_brief: Wide anterior fontanel
systematic_name: M34629
exact_source: HP:0000260
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000260
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Enlargement of the anterior fontanelle with respect to age-dependent norms. [https://orcid.org/0000-0002-0736-9199]


description_brief: Oxycephaly
systematic_name: M34631
exact_source: HP:0000263
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000263
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Oxycephaly (from Greek oxus, sharp, and kephalos, head) refers to a conical or pointed shape of the skull. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal mastoid morphology
systematic_name: M34632
exact_source: HP:0000264
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000264
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the mastoid process, which is the conical prominence projecting from the undersurface of the mastoid portion of the temporal bone. [https://orcid.org/0000-0002-0736-9199]


description_brief: Dolichocephaly
systematic_name: M34635
exact_source: HP:0000268
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000268
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of skull shape characterized by a increased anterior-posterior diameter, i.e., an increased antero-posterior dimension of the skull. Cephalic index less than 76%. Alternatively, an apparently increased antero-posterior length of the head compared to width. Often due to premature closure of the sagittal suture. [https://orcid.org/0000-0002-0736-9199, PMID:19125436]


description_brief: Delayed cranial suture closure
systematic_name: M34637
exact_source: HP:0000270
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000270
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Infants normally have two fontanels at birth, the diamond-shaped anterior fontanelle at the junction of the coronal and sagittal sutures, and the posterior fontanelle at the intersection of the occipital and parietal bones. The posterior fontanelle usually closes by the 8th week of life, and the anterior fontanel closes by the 18th month of life on average. This term applies if there is delay of closure of the fontanelles beyond the normal age. [https://orcid.org/0000-0002-0736-9199]


description_brief: Malar flattening
systematic_name: M46055
exact_source: HP:0000272
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000272
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Underdevelopment of the malar prominence of the jugal bone (zygomatic bone in mammals), appreciated in profile, frontal view, and/or by palpation. [https://orcid.org/0000-0001-5889-4463, https://orcid.org/0000-0002-0736-9199, PMID:19125436]


description_brief: Narrow face
systematic_name: M43253
exact_source: HP:0000275
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000275
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Bizygomatic (upper face) and bigonial (lower face) width are both more than 2 standard deviations below the mean (objective); or, an apparent reduction in the width of the upper and lower face (subjective). [PMID:19125436]


description_brief: Retrognathia
systematic_name: M34641
exact_source: HP:0000278
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000278
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality in which the mandible is mislocalised posteriorly. [https://orcid.org/0000-0002-0736-9199]


description_brief: Coarse facial features
systematic_name: M34642
exact_source: HP:0000280
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000280
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Absence of fine and sharp appearance of brows, nose, lips, mouth, and chin, usually because of rounded and heavy features or thickened skin with or without thickening of subcutaneous and bony tissues. [PMID:19125436]


description_brief: Broad face
systematic_name: M34644
exact_source: HP:0000283
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000283
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Bizygomatic (upper face) and bigonial (lower face) width greater than 2 standard deviations above the mean (objective); or an apparent increase in the width of the face (subjective). [PMID:19125436]


description_brief: Epicanthus
systematic_name: M34645
exact_source: HP:0000286
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000286
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A fold of skin starting above the medial aspect of the upper eyelid and arching downward to cover, pass in front of and lateral to the medial canthus. [https://orcid.org/0000-0002-0736-9199]


description_brief: Broad philtrum
systematic_name: M34647
exact_source: HP:0000289
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000289
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between the philtral ridges, measured just above the vermilion border, more than 2 standard deviations above the mean, or alternatively, an apparently increased distance between the ridges of the philtrum. [PMID:19152422]


description_brief: Full cheeks
systematic_name: M34650
exact_source: HP:0000293
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000293
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Increased prominence or roundness of soft tissues between zygomata and mandible. [https://orcid.org/0000-0002-2972-5481]


description_brief: Low anterior hairline
systematic_name: M34651
exact_source: HP:0000294
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000294
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between the hairline (trichion) and the glabella (the most prominent point on the frontal bone above the root of the nose), in the midline, more than two SD below the mean. Alternatively, an apparently decreased distance between the hairline and the glabella. [PMID:19125436]


description_brief: Facial hypotonia
systematic_name: M34652
exact_source: HP:0000297
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000297
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Reduced muscle tone of a muscle that is innervated by the facial nerve (the seventh cranial nerve). [https://orcid.org/0000-0002-0736-9199]


description_brief: Mask-like facies
systematic_name: M34653
exact_source: HP:0000298
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000298
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A lack of facial expression often with staring eyes and a slightly open mouth. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of facial musculature
systematic_name: M34655
exact_source: HP:0000301
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000301
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly of a muscle that is innervated by the facial nerve (the seventh cranial nerve). [https://orcid.org/0000-0002-0736-9199]


description_brief: Mandibular prognathia
systematic_name: M34656
exact_source: HP:0000303
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000303
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormal prominence of the chin related to increased length of the mandible. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of the chin
systematic_name: M34657
exact_source: HP:0000306
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000306
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the chin, i.e., of the inferior portion of the face lying inferior to the lower lip and including the central prominence of the lower jaw. [https://orcid.org/0000-0002-0736-9199, PMID:19125436]


description_brief: Microretrognathia
systematic_name: M34659
exact_source: HP:0000308
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000308
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A form of developmental hypoplasia of the mandible in which the mandible is mislocalised posteriorly. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal midface morphology
systematic_name: M34660
exact_source: HP:0000309
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000309
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly of the midface, which is a region and not an anatomical term. It extends, superiorly, from the inferior orbital margin to, inferiorly, the level of nasal base. It is formed by the maxilla (upper jaw) and zygoma and cheeks and malar region. Traditionally, the nose and premaxilla are not included in the midface. [https://orcid.org/0000-0002-0736-9199, PMID:19125436]


description_brief: Hypertelorism
systematic_name: M34663
exact_source: HP:0000316
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000316
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Interpupillary distance more than 2 SD above the mean (alternatively, the appearance of an increased interpupillary distance or widely spaced eyes). [PMID:19125427]


description_brief: Facial myokymia
systematic_name: M34664
exact_source: HP:0000317
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000317
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Facial myokymia is a fine fibrillary activity of one or more muscles innervated by the facial nerve (the seventh cranial nerve). [https://orcid.org/0000-0002-0736-9199]


description_brief: Smooth philtrum
systematic_name: M34665
exact_source: HP:0000319
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000319
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Flat skin surface, with no ridge formation in the central region of the upper lip between the nasal base and upper vermilion border. [PMID:19152422]


description_brief: Square face
systematic_name: M34667
exact_source: HP:0000321
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000321
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Facial contours, as viewed from the front, show a broad upper face/cranium and lower face/mandible, creating a square appearance. [PMID:19125436]


description_brief: Short philtrum
systematic_name: M34668
exact_source: HP:0000322
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000322
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between nasal base and midline upper lip vermilion border more than 2 SD below the mean. Alternatively, an apparently decreased distance between nasal base and midline upper lip vermilion border. [PMID:19152422]


description_brief: Facial asymmetry
systematic_name: M34669
exact_source: HP:0000324
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000324
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormal difference between the left and right sides of the face. [https://orcid.org/0000-0002-0736-9199]


description_brief: Triangular face
systematic_name: M34670
exact_source: HP:0000325
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000325
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Facial contour, as viewed from the front, triangular in shape, with breadth at the temples and tapering to a narrow chin. [https://orcid.org/0000-0002-9602-2321, PMID:19125436, PMID:21166787, PMID:30515601]


description_brief: Facial hemangioma
systematic_name: M34672
exact_source: HP:0000329
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000329
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Hemangioma, a benign tumor of the vascular endothelial cells, occurring in the face. [https://orcid.org/0000-0002-0736-9199]


description_brief: Short chin
systematic_name: M34673
exact_source: HP:0000331
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000331
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Decreased vertical distance from the vermilion border of the lower lip to the inferior-most point of the chin. [https://orcid.org/0000-0002-0736-9199, PMID:19125436]


description_brief: Prominent supraorbital ridges
systematic_name: M34674
exact_source: HP:0000336
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000336
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Greater than average forward and/or lateral protrusion of the supraorbital portion of the frontal bones. [PMID:19125436]


description_brief: Broad forehead
systematic_name: M34675
exact_source: HP:0000337
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000337
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Width of the forehead or distance between the frontotemporales is more than two standard deviations above the mean (objective); or apparently increased distance between the two sides of the forehead. [PMID:19125436]


description_brief: Hypomimic face
systematic_name: M34676
exact_source: HP:0000338
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000338
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation. [https://orcid.org/0000-0002-0736-9199]


description_brief: Sloping forehead
systematic_name: M34677
exact_source: HP:0000340
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000340
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Inclination of the anterior surface of the forehead from the vertical more than two standard deviations above the mean (objective); or apparently excessive posterior sloping of the forehead in a lateral view. [PMID:19125436]


description_brief: Narrow forehead
systematic_name: M34678
exact_source: HP:0000341
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000341
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Width of the forehead or distance between the frontotemporales is more than two standard deviations below the mean (objective); or apparently narrow intertemporal region (subjective). [PMID:19125436]


description_brief: Long philtrum
systematic_name: M34679
exact_source: HP:0000343
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000343
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between nasal base and midline upper lip vermilion border more than 2 SD above the mean. Alternatively, an apparently increased distance between nasal base and midline upper lip vermilion border. [PMID:19152422]


description_brief: Posteriorly rotated ears
systematic_name: M34685
exact_source: HP:0000358
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000358
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A type of abnormal location of the ears in which the position of the ears is characterized by posterior rotation (the superior part of the ears is rotated towards the back of the head, and the inferior part of the ears towards the front). [https://orcid.org/0000-0002-0736-9199, PMID:19152421]


description_brief: Tinnitus
systematic_name: M34687
exact_source: HP:0000360
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000360
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Tinnitus is an auditory perception that can be described as the experience of sound, in the ear or in the head, in the absence of external acoustic stimulation. []


description_brief: Otosclerosis
systematic_name: M34688
exact_source: HP:0000362
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000362
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  In otosclerosis, a callus of bone accumulates on the stapes creating a partial fixation. This limits the movement of the stapes bone, which results in hearing loss. [https://orcid.org/0000-0002-0736-9199, PMID:15931303]


description_brief: Low-set ears
systematic_name: M47032
exact_source: HP:0000369
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000369
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Upper insertion of the ear to the scalp below an imaginary horizontal line drawn between the inner canthi of the eye and extending posteriorly to the ear. [https://orcid.org/0000-0002-0736-9199, PMID:19152421]


description_brief: Acute otitis media
systematic_name: M34692
exact_source: HP:0000371
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000371
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Acute otitis media is a short and generally painful infection of the middle ear. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal auditory canal morphology
systematic_name: M34693
exact_source: HP:0000372
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000372
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any structural abnormality of the external acoustic tube (also known as the auditory canal). [https://orcid.org/0000-0002-0736-9199]


description_brief: Incomplete partition of the cochlea type II
systematic_name: M43254
exact_source: HP:0000376
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000376
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  With incomplete partition II, the cochlea consists of 1.5 turns; the apical and middle cochlea turns are undifferentiated and form a cystic apex. The vestibule is normal while the vestibular aqueduct is always enlarged. Developmental arrest occurs at the seventh week of gestation. [https://orcid.org/0000-0002-0736-9199, PMID:21849370, PMID:34698066]


description_brief: Cupped ear
systematic_name: M34696
exact_source: HP:0000378
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000378
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Laterally protruding ear that lacks antihelical folding (including absence of inferior and superior crura). [https://orcid.org/0000-0002-0736-9199, PMID:19162421, PMID:22073081]


description_brief: Stapes ankylosis
systematic_name: M41219
exact_source: HP:0000381
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000381
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Stapes ankylosis refers to congenital or acquired fixation of the stapes (the stirrup-shaped small bone or ossicle in the middle ear), which is associated with conductive hearing resulting from impairment of the sound-conduction mechanism (the external auditory canal, tympanic membrane, and/or middle-ear ossicles). [https://orcid.org/0000-0002-0736-9199, PMID:12089654]


description_brief: Preauricular skin tag
systematic_name: M48677
exact_source: HP:0000384
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000384
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A rudimentary tag of skin often containing ear tissue including a core of cartilage and located just anterior to the auricle (outer part of the ear). [https://orcid.org/0000-0002-0736-9199]


description_brief: Absent earlobe
systematic_name: M34700
exact_source: HP:0000387
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000387
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Absence of fleshy non-cartilaginous tissue inferior to the tragus and incisura. [https://orcid.org/0000-0002-0736-9199, PMID:19152421]


description_brief: Chronic otitis media
systematic_name: M34702
exact_source: HP:0000389
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000389
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Chronic otitis media refers to fluid, swelling, or infection of the middle ear that does not heal and may cause permanent damage to the ear. [https://orcid.org/0000-0002-0736-9199]


description_brief: Lop ear
systematic_name: M34704
exact_source: HP:0000394
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000394
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Anterior and inferior folding of the upper portion of the ear that obliterates triangular fossa and scapha. [https://orcid.org/0000-0002-0736-9199, PMID:19152421]


description_brief: Prelingual sensorineural hearing impairment
systematic_name: M34706
exact_source: HP:0000399
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000399
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A form of sensorineural deafness with either congenital onset or infantile onset, i.e., before the acquisition of speech. [https://orcid.org/0000-0002-0736-9199]


description_brief: Macrotia
systematic_name: M34707
exact_source: HP:0000400
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000400
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Median longitudinal ear length greater than two standard deviations above the mean and median ear width greater than two standard deviations above the mean (objective); or, apparent increase in length and width of the pinna (subjective). [PMID:19152421]


description_brief: Recurrent otitis media
systematic_name: M34709
exact_source: HP:0000403
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000403
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Increased susceptibility to otitis media, as manifested by recurrent episodes of otitis media. [https://orcid.org/0000-0002-0736-9199]


description_brief: Mixed hearing impairment
systematic_name: M34711
exact_source: HP:0000410
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000410
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A type of hearing loss resulting from a combination of conductive hearing impairment and sensorineural hearing impairment. [https://orcid.org/0000-0002-0736-9199]


description_brief: Protruding ear
systematic_name: M34712
exact_source: HP:0000411
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000411
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Angle formed by the plane of the ear and the mastoid bone greater than the 97th centile for age (objective); or, outer edge of the helix more than 2 cm from the mastoid at the point of maximum distance (objective). [PMID:19152421]


description_brief: Epistaxis
systematic_name: M34718
exact_source: HP:0000421
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000421
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Epistaxis, or nosebleed, refers to a hemorrhage localized in the nose. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal nasal bridge morphology
systematic_name: M34719
exact_source: HP:0000422
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000422
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormality of the nasal bridge, which is the saddle-shaped area that includes the nasal root and the lateral aspects of the nose. It lies between the glabella and the inferior boundary of the nasal bone, and extends laterally to the inner canthi. [https://orcid.org/0000-0002-0736-9199, PMID:19152422]


description_brief: Prominent nasal bridge
systematic_name: M34720
exact_source: HP:0000426
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000426
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Anterior positioning of the nasal root in comparison to the usual positioning for age. [PMID:19152422]


description_brief: Wide nasal bridge
systematic_name: M34723
exact_source: HP:0000431
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000431
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Increased breadth of the nasal bridge (and with it, the nasal root). [https://orcid.org/0000-0002-0736-9199, PMID:19152422]


description_brief: Convex nasal ridge
systematic_name: M34727
exact_source: HP:0000444
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000444
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Nasal ridge curving anteriorly to an imaginary line that connects the nasal root and tip. The nose appears often also prominent, and the columella low. [PMID:19152422]


description_brief: Wide nose
systematic_name: M34728
exact_source: HP:0000445
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000445
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Interalar distance more than two standard deviations above the mean for age, i.e., an apparently increased width of the nasal base and alae. [PMID:19152422]


description_brief: Prominent nose
systematic_name: M34730
exact_source: HP:0000448
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000448
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between subnasale and pronasale more than two standard deviations above the mean, or alternatively, an apparently increased anterior protrusion of the nasal tip. [PMID:19152422]


description_brief: Choanal stenosis
systematic_name: M34731
exact_source: HP:0000452
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000452
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormal narrowing of the choana (the posterior nasal aperture). [https://orcid.org/0000-0002-0736-9199]


description_brief: Choanal atresia
systematic_name: M48678
exact_source: HP:0000453
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000453
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Absence or abnormal closure of the choana (the posterior nasal aperture). Most embryologists believe that posterior choanal atresia results from a failure of rupture between the 35th and 38th day of fetal life of the partition which separates the bucconasal or buccopharyngeal membranes. The resultant choanal atresia may be unilateral or bilateral, bony or membranous, complete or incomplete. In over 90 per cent of cases the obstruction is bony, while in the remainder it is membranous. The bony type of atresia is commonly located 1-2 mm. anterior to the posterior edge of the hard palate, and the osseous septum varies in thickness from 1 to 10 mm. In the membranous form of choanal atresia the obstruction usually occurs further posteriorly. In approximately one third of cases the atresia is bilateral. [https://orcid.org/0000-0001-5889-4463, PMID:4996574]


description_brief: Bifid nasal tip
systematic_name: M34734
exact_source: HP:0000456
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000456
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A splitting of the nasal tip. Visually assessable vertical indentation, cleft, or depression of the nasal tip. [https://orcid.org/0009-0006-4530-3154, PMID:19152422]


description_brief: Depressed nasal ridge
systematic_name: M34735
exact_source: HP:0000457
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000457
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Lack of prominence of the nose resulting from a posteriorly-placed nasal ridge. [https://orcid.org/0000-0002-0736-9199, PMID:19152422]


description_brief: Anosmia
systematic_name: M34736
exact_source: HP:0000458
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000458
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An inability to perceive odors. This is a general term describing inability to smell arising in any part of the process of smelling from absorption of odorants into the nasal mucous overlying the olfactory epithelium, diffusion to the cilia, binding to olfactory receptor sites, generation of action potentials in olfactory neurons, and perception of a smell. [https://orcid.org/0000-0002-0736-9199]


description_brief: Narrow nose
systematic_name: M34737
exact_source: HP:0000460
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000460
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Interalar distance more than 2 SD below the mean for age, or alternatively, an apparently decreased width of the nasal base and alae. [PMID:19152422]


description_brief: Webbed neck
systematic_name: M34739
exact_source: HP:0000465
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000465
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Pterygium colli is a congenital skin fold that runs along the sides of the neck down to the shoulders. It involves an ectopic fibrotic facial band superficial to the trapezius muscle. Excess hair-bearing skin is also present and extends down the cervical region well beyond the normal hairline. [https://orcid.org/0000-0002-0736-9199, PMID:24523736]


description_brief: Thickened nuchal skin fold
systematic_name: M34743
exact_source: HP:0000474
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000474
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A thickening of the skin thickness in the posterior aspect of the fetal neck. A nuchal fold (NF) measurement is obtained in a transverse section of the fetal head at the level of the cavum septum pellucidum and thalami, angled posteriorly to include the cerebellum. The measurement is taken from the outer edge of the occiput bone to the outer skin limit directly in the midline. An NF measurement greater than 5 mm at 14 to 17+6 weeks of gestation, or 6 mm at 18 to 28 weeks has been associated with a markedly increased risk for Down syndrome. [https://orcid.org/0000-0002-0736-9199, PMID:16100637, PMID:30431620]


description_brief: Abnormal cornea morphology
systematic_name: M34748
exact_source: HP:0000481
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000481
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any abnormality of the cornea, which is the transparent tissue at the front of the eye that covers the iris, pupil, and anterior chamber. [https://orcid.org/0000-0002-0736-9199]


description_brief: Microcornea
systematic_name: M34749
exact_source: HP:0000482
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000482
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A congenital abnormality of the cornea in which the cornea and the anterior segment of the eye are smaller than normal. The horizontal diameter of the cornea does not reach 10 mm even in adulthood. [https://orcid.org/0000-0002-0736-9199]


description_brief: Astigmatism
systematic_name: M34750
exact_source: HP:0000483
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000483
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A type of astigmatism associated with abnormal curvatures on the anterior and/or posterior surface of the cornea. [HPO_CONTRIBUTOR:DDD_ncarter, https://orcid.org/0000-0002-0736-9199, https://orcid.org/0000-0003-0986-4123]


description_brief: Hyperopic astigmatism
systematic_name: M46056
exact_source: HP:0000484
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000484
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A form of astigmatism in which one meridian is hyperopic while the one at a right angle to it has no refractive error. [https://orcid.org/0000-0002-0736-9199]


description_brief: Megalocornea
systematic_name: M34751
exact_source: HP:0000485
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000485
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An enlargement of the cornea with normal clarity and function. Megalocornea is diagnosed with a horizontal corneal diameter of 12 mm or more at birth or 13 mm or more after two years of age. [https://orcid.org/0000-0002-0736-9199]


description_brief: Retinopathy
systematic_name: M34752
exact_source: HP:0000488
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000488
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal foveal morphology
systematic_name: M34756
exact_source: HP:0000493
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000493
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the fovea centralis, the central area of the macula that mediates central, high resolution vision and contains the largest concentration of cone cells in the retina. [https://orcid.org/0000-0002-0736-9199]


description_brief: Downslanted palpebral fissures
systematic_name: M34757
exact_source: HP:0000494
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000494
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The palpebral fissure inclination is more than two standard deviations below the mean. [PMID:19125427]


description_brief: Recurrent corneal erosions
systematic_name: M34758
exact_source: HP:0000495
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000495
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of recurrent corneal epithelial erosions. Although most corneal epithelial defects heal quickly, some may show recurrent ulcerations. [https://orcid.org/0000-0002-0736-9199]


description_brief: Glaucoma
systematic_name: M34761
exact_source: HP:0000501
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000501
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure. [https://orcid.org/0000-0002-0736-9199, PMID:11815354]


description_brief: Visual impairment
systematic_name: M34764
exact_source: HP:0000505
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000505
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery. [https://orcid.org/0000-0001-8727-6592]


description_brief: Telecanthus
systematic_name: M34765
exact_source: HP:0000506
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000506
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between the inner canthi more than two standard deviations above the mean (objective); or, apparently increased distance between the inner canthi. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ptosis
systematic_name: M34766
exact_source: HP:0000508
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000508
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The upper eyelid margin is positioned 3 mm or more lower than usual and covers the superior portion of the iris (objective); or, the upper lid margin obscures at least part of the pupil (subjective). [PMID:19125427]


description_brief: Rod-cone dystrophy
systematic_name: M34767
exact_source: HP:0000510
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000510
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An inherited retinal disease subtype in which the rod photoreceptors appear to be more severely affected than the cone photoreceptors. Typical presentation is with nyctalopia (due to rod dysfunction) followed by loss of mid-peripheral field of vision, which gradually extends and leaves many patients with a small central island of vision due to the preservation of macular cones. [https://orcid.org/0000-0002-0736-9199, PMID:20212494]


description_brief: Vertical supranuclear gaze palsy
systematic_name: M34768
exact_source: HP:0000511
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000511
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A supranuclear gaze palsy is an inability to look in a vertical direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal. [https://orcid.org/0000-0002-0736-9199, PMID:20671861]


description_brief: Abnormal electroretinogram
systematic_name: M34769
exact_source: HP:0000512
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000512
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any abnormality of the electrical responses of various cell types in the retina as measured by electroretinography. [https://orcid.org/0000-0002-0736-9199]


description_brief: Developmental cataract
systematic_name: M34772
exact_source: HP:0000519
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000519
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A cataract that occurs congenitally as the result of a developmental defect, in contrast to the majority of cataracts that occur in adulthood as the result of degenerative changes of the lens. [https://orcid.org/0000-0002-0736-9199]


description_brief: Proptosis
systematic_name: M34773
exact_source: HP:0000520
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000520
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An eye that is protruding anterior to the plane of the face to a greater extent than is typical. [https://orcid.org/0009-0006-4530-3154, PMID:19125427]


description_brief: Subcapsular cataract
systematic_name: M34775
exact_source: HP:0000523
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000523
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A cataract that affects the region of the lens directly beneath the capsule of the lens. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality iris morphology
systematic_name: M34776
exact_source: HP:0000525
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000525
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the iris, which is the pigmented muscular tissue between the cornea and the lens, that is perforated by an opening called the pupil. [https://orcid.org/0000-0002-0736-9199]


description_brief: Aniridia
systematic_name: M34777
exact_source: HP:0000526
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000526
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormality of the iris characterized by, typically bilateral, complete or partial iris hypoplasia. The phenotype ranges from mild defects of anterior iris stroma only to almost complete absence of the iris. [https://orcid.org/0000-0002-0736-9199, https://orcid.org/0000-0003-0986-4123, PMID:24138039, PMID:25313118, PMID:29850208]


description_brief: Long eyelashes
systematic_name: M34778
exact_source: HP:0000527
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000527
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Mid upper eyelash length >10 mm or increased length of the eyelashes (subjective). [PMID:19125427, PMID:26288407]


description_brief: Chorioretinal atrophy
systematic_name: M34782
exact_source: HP:0000533
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000533
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Atrophy of the choroid and retinal layers of the fundus. [https://orcid.org/0000-0002-0736-9199, PMID:20224472]


description_brief: Epicanthus inversus
systematic_name: M34784
exact_source: HP:0000537
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000537
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A fold of skin starting at or just below the medial aspect of the lower lid and arching upward to cover, extend in front of and lateral to the medial canthus. [PMID:19125427]


description_brief: Abnormality of refraction
systematic_name: M34785
exact_source: HP:0000539
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000539
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality in the process of focusing of light by the eye in order to produce a sharp image on the retina. [https://orcid.org/0000-0002-0736-9199]


description_brief: Hypermetropia
systematic_name: M34786
exact_source: HP:0000540
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000540
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of refraction characterized by the ability to see objects in the distance clearly, while objects nearby appear blurry. [https://orcid.org/0000-0002-0736-9199]


description_brief: Retinal detachment
systematic_name: M34787
exact_source: HP:0000541
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000541
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Separation of the inner layers of the retina (neural retina) from the pigment epithelium. [https://orcid.org/0000-0002-0736-9199]


description_brief: Impaired ocular adduction
systematic_name: M47035
exact_source: HP:0000542
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000542
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Reduced ability to move the eye in the direction of the nose. [https://orcid.org/0000-0002-0736-9199]


description_brief: Optic disc pallor
systematic_name: M34788
exact_source: HP:0000543
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000543
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A pale yellow discoloration of the optic disc (the area of the optic nerve head in the retina). The optic disc normally has a pinkish hue with a central yellowish depression. [https://orcid.org/0000-0002-0736-9199]


description_brief: Myopia
systematic_name: M34790
exact_source: HP:0000545
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000545
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of refraction characterized by the ability to see objects nearby clearly, while objects in the distance appear blurry. [https://orcid.org/0000-0002-0736-9199]


description_brief: Retinal degeneration
systematic_name: M34791
exact_source: HP:0000546
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000546
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells. [https://orcid.org/0000-0002-0736-9199, https://orcid.org/0000-0003-0986-4123]


description_brief: Abnormal conjugate eye movement
systematic_name: M34793
exact_source: HP:0000549
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000549
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object. [https://orcid.org/0000-0002-0736-9199]


description_brief: Undetectable electroretinogram
systematic_name: M34794
exact_source: HP:0000550
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000550
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Lack of any response to stimulation upon electroretinography. [https://orcid.org/0000-0002-0736-9199]


description_brief: Color vision defect
systematic_name: M34795
exact_source: HP:0000551
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000551
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly in the ability to discriminate between or recognize colors. [https://orcid.org/0000-0002-0736-9199]


description_brief: Tritanomaly
systematic_name: M34796
exact_source: HP:0000552
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000552
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Difficulty distinguishing between yellow and blue, possible related to dysfunction of the S photopigment. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal uvea morphology
systematic_name: M34797
exact_source: HP:0000553
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000553
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the uvea, the vascular layer of the eyeball. [https://orcid.org/0000-0002-0736-9199]


description_brief: Leukocoria
systematic_name: M45393
exact_source: HP:0000555
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000555
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormal white reflection from the pupil rather than the usual black reflection. [https://orcid.org/0000-0002-0736-9199]


description_brief: Retinal dystrophy
systematic_name: M34799
exact_source: HP:0000556
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000556
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Retinal dystrophy is an abnormality of the retina associated with a hereditary process. Retinal dystrophies are defined by their predominantly monogenic inheritance and they are frequently associated with loss or dysfunction of photoreceptor cells as a primary or secondary event. [https://orcid.org/0000-0003-0986-4123]


description_brief: Rieger anomaly
systematic_name: M34801
exact_source: HP:0000558
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000558
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A congenital malformation of the anterior segment characterized by iridicorneal malformation, glaucoma, iris stroma hypoplasia, posterior embryotoxon, and corneal opacities. [https://orcid.org/0000-0002-0736-9199]


description_brief: Lacrimal duct atresia
systematic_name: M41220
exact_source: HP:0000564
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000564
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A developmental disorder of the lacrimal drainage system that most often affects the lacrimal ostium and resulting in non-opening of the nasolacrimal duct. It usually results from a non-canalization of the nasolacrimal duct. [https://orcid.org/0000-0002-0736-9199]


description_brief: Chorioretinal coloboma
systematic_name: M34803
exact_source: HP:0000567
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000567
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Absence of a region of the retina, retinal pigment epithelium, and choroid. [https://orcid.org/0000-0002-0736-9199]


description_brief: Microphthalmia
systematic_name: M47036
exact_source: HP:0000568
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000568
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A developmental anomaly characterized by abnormal smallness of one or both eyes. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal saccadic eye movements
systematic_name: M34804
exact_source: HP:0000570
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000570
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of eye movement characterized by impairment of fast (saccadic) eye movements. [https://orcid.org/0000-0002-0736-9199]


description_brief: Hypometric saccades
systematic_name: M34805
exact_source: HP:0000571
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000571
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Saccadic undershoot, i.e., a saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object. [https://orcid.org/0000-0002-0736-9199, PMID:572501]


description_brief: Visual loss
systematic_name: M34806
exact_source: HP:0000572
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000572
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Loss of visual acuity (implying that vision was better at a certain time point in life). Otherwise the term reduced visual acuity should be used (or a subclass of that). [https://orcid.org/0009-0006-4530-3154]


description_brief: Scotoma
systematic_name: M34809
exact_source: HP:0000575
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000575
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A regional and pathological increase of the light detection threshold in any region of the visual field surrounded by a field of normal or relatively well-preserved vision. [https://orcid.org/0000-0002-0736-9199]


description_brief: Centrocecal scotoma
systematic_name: M34810
exact_source: HP:0000576
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000576
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A scotoma (area of diminished vision within the visual field) located between the central point of fixation and the blind spot with a roughly horizontal oval shape. [https://orcid.org/0000-0002-0736-9199]


description_brief: Pigmentary retinopathy
systematic_name: M34812
exact_source: HP:0000580
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000580
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the retina characterized by pigment deposition. It is typically associated with migration and proliferation of macrophages or retinal pigment epithelial cells into the retina; melanin from these cells causes the pigmentary changes. Pigmentary retinopathy is a common final pathway of many retinal conditions and is often associated with visual loss. [https://orcid.org/0000-0003-0986-4123]


description_brief: Blepharophimosis
systematic_name: M34813
exact_source: HP:0000581
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000581
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A fixed reduction in the vertical distance between the upper and lower eyelids with short palpebral fissures. [PMID:19125427]


description_brief: Upslanted palpebral fissure
systematic_name: M34814
exact_source: HP:0000582
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000582
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The palpebral fissure inclination is more than two standard deviations above the mean for age (objective); or, the inclination of the palpebral fissure is greater than typical for age. [PMID:19125427]


description_brief: Band keratopathy
systematic_name: M34815
exact_source: HP:0000585
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000585
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the cornea characterized by the deposition of calcium in a band across the central cornea, leading to decreased vision, foreign body sensation, and ocular irritation. [https://orcid.org/0000-0002-0736-9199]


description_brief: Shallow orbits
systematic_name: M48679
exact_source: HP:0000586
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000586
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Reduced depth of the orbits associated with prominent-appearing ocular globes. [https://orcid.org/0000-0002-0736-9199]


description_brief: Optic disc coloboma
systematic_name: M34818
exact_source: HP:0000588
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000588
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A cleft of the optic nerve that extends inferiorly. [https://orcid.org/0000-0002-0736-9199, PMID:16219745]


description_brief: Coloboma
systematic_name: M34819
exact_source: HP:0000589
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000589
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A developmental defect characterized by a cleft of some portion of the eye or ocular adnexa. [https://orcid.org/0000-0002-0736-9199]


description_brief: Progressive external ophthalmoplegia
systematic_name: M34820
exact_source: HP:0000590
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000590
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Initial bilateral ptosis followed by limitation of eye movements in all directions and slowing of saccades. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormal anterior chamber morphology
systematic_name: M34823
exact_source: HP:0000593
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000593
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormality of the anterior chamber, which is the space in the eye that is behind the cornea and in front of the iris. [https://orcid.org/0000-0002-0736-9199]


description_brief: Shallow anterior chamber
systematic_name: M34824
exact_source: HP:0000594
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000594
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Reduced depth of the anterior chamber, i.e., the anteroposterior distance between the cornea and the iris is decreased. [https://orcid.org/0000-0002-0736-9199]


description_brief: Ophthalmoparesis
systematic_name: M34825
exact_source: HP:0000597
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000597
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of the frontal hairline
systematic_name: M34826
exact_source: HP:0000599
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000599
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly in the placement or shape of the hairline (trichion) on the forehead, that is, the border between skin on the forehead that has head hair and that does not. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of the pharynx
systematic_name: M34827
exact_source: HP:0000600
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000600
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly of the pharynx, i.e., of the tubular structure extending from the base of the skull superiorly to the esophageal inlet inferiorly. [https://orcid.org/0000-0002-0736-9199]


description_brief: Hypotelorism
systematic_name: M34828
exact_source: HP:0000601
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000601
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Interpupillary distance less than 2 SD below the mean (alternatively, the appearance of an decreased interpupillary distance or closely spaced eyes). [https://orcid.org/0000-0002-0736-9199, PMID:19125427]


description_brief: Central scotoma
systematic_name: M34829
exact_source: HP:0000603
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000603
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An area of depressed vision located at the point of fixation and that interferes with central vision. [https://orcid.org/0000-0002-0736-9199]


description_brief: Supranuclear gaze palsy
systematic_name: M34830
exact_source: HP:0000605
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000605
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A supranuclear gaze palsy is an inability to look in a particular direction as a result of cerebral impairment. There is a loss of the voluntary aspect of eye movements, but, as the brainstem is still intact, all the reflex conjugate eye movements are normal. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of the periorbital region
systematic_name: M34831
exact_source: HP:0000606
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000606
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the region situated around the orbit of the eye. [https://orcid.org/0000-0002-0736-9199]


description_brief: Macular degeneration
systematic_name: M34832
exact_source: HP:0000608
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000608
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A nonspecific term denoting degeneration of the retinal pigment epithelium and/or retinal photoreceptor cells of the macula lutea. [https://orcid.org/0000-0002-0736-9199, https://orcid.org/0000-0003-0986-4123]


description_brief: Photophobia
systematic_name: M34836
exact_source: HP:0000613
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000613
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light. []


description_brief: Abnormal nasolacrimal system morphology
systematic_name: M34837
exact_source: HP:0000614
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000614
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of the nasolacrimal drainage system, which serves as a conduit for tear flow from the external eye to the nasal cavity. [HPO_CONTRIBUTOR:DDD_ncarter]


description_brief: Abnormality of ocular smooth pursuit
systematic_name: M34840
exact_source: HP:0000617
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000617
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormality of eye movement characterized by impaired smooth-pursuit eye movements. [https://orcid.org/0000-0002-0736-9199]


description_brief: Blindness
systematic_name: M34841
exact_source: HP:0000618
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000618
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Blindness is the condition of lacking visual perception defined as a profound reduction in visual perception. On the 6m visual acuity scale, blindness is defined as less than 3/60. On the 20ft visual acuity scale, blindness is defined as less than 20/400. On the decimal visual acuity scale, blindness is defined as less than 0.05. Blindness is typically characterized by a visual field of no greater than 10 degrees in radius around central fixation. [https://orcid.org/0000-0001-8727-6592, PMID:28779882]


description_brief: Entropion
systematic_name: M34843
exact_source: HP:0000621
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000621
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An abnormal inversion (turning inward) of the eyelid (usually the lower) towards the globe. Entropion is usually acquired as a result of involutional or cicatricial processes but may occasionally be congenital. [https://orcid.org/0000-0003-0986-4123, PMID:19125427]


description_brief: Blurred vision
systematic_name: M34844
exact_source: HP:0000622
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000622
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Lack of sharpness of vision resulting in the inability to see fine detail. [https://orcid.org/0000-0002-0736-9199]


description_brief: Supranuclear ophthalmoplegia
systematic_name: M34845
exact_source: HP:0000623
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000623
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A vertical gaze palsy with inability to direct the gaze of the eyes downwards. [https://orcid.org/0000-0002-0736-9199, PMID:20629667]


description_brief: Posterior embryotoxon
systematic_name: M48680
exact_source: HP:0000627
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000627
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A posterior embryotoxon is the presence of a prominent and anteriorly displaced line of Schwalbe. [https://orcid.org/0000-0002-0736-9199]


description_brief: Retinal arterial tortuosity
systematic_name: M48681
exact_source: HP:0000631
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000631
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The presence of an increased number of twists and turns of the retinal artery. [https://orcid.org/0000-0002-0736-9199]


description_brief: Decreased lacrimation
systematic_name: M34851
exact_source: HP:0000633
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000633
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Abnormally decreased lacrimation, that is, reduced ability to produce tears. [https://orcid.org/0000-0002-0736-9199]


description_brief: Impaired ocular abduction
systematic_name: M46058
exact_source: HP:0000634
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000634
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An impaired ability of the eye to move in the outward direction (towards the side of the head). [https://orcid.org/0000-0002-0736-9199]


description_brief: Long palpebral fissure
systematic_name: M34854
exact_source: HP:0000637
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000637
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Distance between medial and lateral canthi is more than two standard deviations above the mean for age (objective); or, apparently increased length of the palpebral fissures. [PMID:19125427]


description_brief: Gaze-evoked nystagmus
systematic_name: M34855
exact_source: HP:0000640
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000640
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Nystagmus made apparent by looking to the right or to the left. [https://orcid.org/0000-0002-0736-9199]


description_brief: Dysmetric saccades
systematic_name: M34856
exact_source: HP:0000641
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000641
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  The controller signal for saccadic eye movements has two components: the pulse that moves the eye rapidly from one point to the next, and the step that holds the eye in the new position. When both the pulse and the step are not the correct size, a dysmetric refixation eye movement results. [https://orcid.org/0000-0002-0736-9199, PMID:572501]


description_brief: Amblyopia
systematic_name: M34858
exact_source: HP:0000646
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000646
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Reduced visual acuity that is uncorrectable by lenses in the absence of detectable anatomic defects in the eye or visual pathways. [https://orcid.org/0000-0002-0736-9199]


description_brief: Sclerocornea
systematic_name: M34859
exact_source: HP:0000647
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000647
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  A congenital anomaly in which a part or the whole of the cornea acquires the characteristics of sclera, resulting in clouding of the cornea. [https://orcid.org/0000-0002-0736-9199]


description_brief: Optic atrophy
systematic_name: M41221
exact_source: HP:0000648
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000648
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  Atrophy of the optic nerve. Optic atrophy results from the death of the retinal ganglion cell axons that comprise the optic nerve and manifesting as a pale optic nerve on fundoscopy. [https://orcid.org/0000-0002-0736-9199]


description_brief: Abnormality of visual evoked potentials
systematic_name: M34860
exact_source: HP:0000649
external_details_URL: https://hpo.jax.org/app/browse/term/HP:0000649
source_species_code: HS
contributor: Human Phenotype Ontology Group
contrib_organization: The Jackson Laboratory (JAX)
description_full:
  An anomaly of visually evoked potentials (VEP), which are electrical potentials, initiated by brief visual stimuli, which are recorded from the scalp overlying the visual cortex. [https://orcid.org/0000-0002-0736-9199, PMID:19826847]


