# gene_set_details

systematic_name: M25901
exact_source: GO:0070847
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070847
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The core mediator complex has a stimulatory effect on basal transcription, and contains most of the same subdomains as the larger form of mediator complex -- a head domain comprising proteins known in Saccharomyces as Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; and a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p -- but lacks the regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan core mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. [PMID:11454195, PMID:16168358, PMID:17870225]


systematic_name: M25902
exact_source: GO:0070852
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070852
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A neuron projection that is found in unipolar neurons and corresponds to the region between the cell body and the point at which the single projection branches. [GOC:dos, GOC:mah]


systematic_name: M25903
exact_source: GO:0070937
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070937
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the coding region instability determinant (CRD). In human, it may consist of IGF2BP1, HNRNPU, SYNCRIP/HNRNPQ, YBX1, and DHX9. [GOC:mah, PMID:19029303]


systematic_name: M25904
exact_source: GO:0070938
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070938
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles. [GOC:mah, ISBN:0123645859, ISBN:0792354923, PMID:10791428, PMID:17913889]


systematic_name: M25905
exact_source: GO:0070971
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070971
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An endoplasmic reticulum part at which COPII-coated vesicles are produced. [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052]


systematic_name: M17745
exact_source: GO:0070993
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0070993
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonucleoprotein complex that contains the small ribosomal subunit, a translation initiation ternary complex (i.e. an initiator tRNA, GTP, and an IF2 or eIF2 complex), and an mRNA. [GOC:hjd, GOC:mah]


systematic_name: M25906
exact_source: GO:0071007
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071007
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]


systematic_name: M17478
exact_source: GO:0071010
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071010
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal complex that is formed by association of the 5' splice site and the branch point sequence with specific snRNPs. The prespliceosome includes many proteins in addition to those found in the bound snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation. Prespliceosome complexes are not active for splicing, but are instead an early step in the assembly of a spliceosomal complex. [GOC:ab, GOC:krc, GOC:mah, PMID:17332742, PMID:19239890]


systematic_name: M17178
exact_source: GO:0071011
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071011
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal complex that is formed by the recruitment of a preassembled U5-containing tri-snRNP to the prespliceosome. Although all 5 snRNPs are present, the precatalytic spliceosome is catalytically inactive. The precatalytic spliceosome includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]


systematic_name: M25907
exact_source: GO:0071012
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071012
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal complex that is formed by the displacement of the two snRNPs from the precatalytic spliceosome; three snRNPs including U5 remain associated with the mRNA. This complex, sometimes called the activated spliceosome, is the catalytically active form of the spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, PMID:18322460, PMID:19239890]


systematic_name: M17484
exact_source: GO:0071013
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071013
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal complex that contains three snRNPs, including U5, bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the associated snRNPs. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393, PMID:18322460, PMID:19239890]


systematic_name: M25908
exact_source: GO:0071014
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071014
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, either U2 or U12, U5, and either U6 or U6atac. [GOC:ab, GOC:krc, GOC:mah, ISBN:0879695897, PMID:19239890, PMID:20149226]


systematic_name: M25909
exact_source: GO:0071141
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071141
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. Heteromeric complexes act as transcription factors while homomeric complexes exist but are transcriptionally inactive. Hetero- versus homotrimerization is largely enthalpy driven. [GOC:bhm, GOC:mah, PMID:9670020]


systematic_name: M48594
exact_source: GO:0071159
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071159
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. [ISBN:0849327946]


systematic_name: M46944
exact_source: GO:0071162
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071162
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that contains the GINS complex, Cdc45p, and the heterohexameric MCM complex, and that is involved in unwinding DNA during replication. [GOC:rb, PMID:19228417]


systematic_name: M17688
exact_source: GO:0071203
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071203
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In human, the WASH complex is composed of F-actin-capping protein subunits alpha and beta, WASH1, FAM21, KIAA1033, KIAA0196 and CCDC53. [GOC:sp, PMID:19922875]


systematic_name: M25910
exact_source: GO:0071204
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071204
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonucleoprotein that binds to specific sites in, and is required for cleavage of, the 3'-end of histone pre-mRNAs. The complex contains the U7 snRNP and additional proteins, including the stem-loop binding protein (SLBP) and the exonuclease 3'hExo/Eri-1. [GOC:mah, PMID:19470752]


systematic_name: M25911
exact_source: GO:0071256
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071256
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that constitutes a specific site of protein translocation across the endoplasmic reticulum, which involves the signal recognition particle receptor. The complex contains a core heterotrimer of alpha, beta and gamma subunits, and may contain additional proteins. [GOC:mah, PMID:10611978, PMID:18166647, PMID:8612571]


systematic_name: M25913
exact_source: GO:0071439
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071439
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that consists of three clathrin heavy chains and three clathrin light chains, organized into a symmetrical three-legged structure called a triskelion. In clathrin-coated vesicles clathrin is the main component of the coat and forms a polymeric mechanical scaffold on the vesicle surface. [GOC:mah, PMID:16493411]


systematic_name: M25915
exact_source: GO:0071541
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071541
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An eukaryotic translation initiation factor 3 complex that contains the PCI-domain protein eIF3m. [PMID:15904532, PMID:19061185]


systematic_name: M25916
exact_source: GO:0071546
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071546
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A P granule that contains the PIWIL2-TDRD1 module, a set of proteins that act in the primary piRNA pathway. The pi-body corresponds to the cementing material between mitochondria found in gonocytes. [GOC:sp, PMID:20011505]


systematic_name: M25917
exact_source: GO:0071547
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071547
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A P granule that contains the PIWIL4-TDRD9 module, a set of proteins that act in the secondary piRNA pathway. [GOC:sp, PMID:20011505]


systematic_name: M17209
exact_source: GO:0071564
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071564
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A SWI/SNF-type complex that is found in neural stem or progenitor cells, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A genes. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. [GOC:mah, GOC:ss, PMID:17640523]


systematic_name: M17757
exact_source: GO:0071565
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071565
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A SWI/SNF-type complex that is found in post-mitotic neurons, and in human contains actin and proteins encoded by the ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B genes. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [GOC:mah, GOC:ss, PMID:17640523]


systematic_name: M43130
exact_source: GO:0071598
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071598
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonucleoprotein complex that is found in the cytoplasm of axons and dendrites, and transports translationally silenced mRNAs to dendritic synapses, where they are released and translated in response to specific exogenous stimuli. [GOC:BHF, GOC:go_curators, GOC:mah, PMID:19015237, PMID:20368989]


systematic_name: M45316
exact_source: GO:0071735
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071735
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex composed of two identical immunoglobulin heavy chains of an IgG isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgG immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]


systematic_name: M45317
exact_source: GO:0071738
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071738
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex composed of two identical immunoglobulin heavy chains of the IgD isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgD immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:11282392]


systematic_name: M45318
exact_source: GO:0071742
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071742
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex composed of two identical immunoglobulin heavy chains of the IgE isotype and two identical immunoglobulin light chains, held together by disulfide bonds. An IgE immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196]


systematic_name: M40608
exact_source: GO:0071745
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071745
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex composed of two identical immunoglobulin heavy chains of the IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and sometimes complexed with J chain or J chain and secretory component. An IgA immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]


systematic_name: M45319
exact_source: GO:0071746
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071746
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex composed of two identical immunoglobulin heavy chains of an IgA isotype and two identical immunoglobulin light chains, held together by disulfide bonds, sometimes complexed with J chain or J chain and secretory component, and present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:16362985]


systematic_name: M45320
exact_source: GO:0071753
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071753
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex composed of two identical immunoglobulin heavy chains of the IgM isotype and two identical immunoglobulin light chains, held together by disulfide bonds, and in its circulating form complexed with J chain in polymeric forms. An IgM immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. [GOC:add, ISBN:0781765196, PMID:20176268]


systematic_name: M17015
exact_source: GO:0071782
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071782
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A subcompartment of the endoplasmic reticulum consisting of tubules having membranes with high curvature in cross-section. [GOC:vw, PMID:16469703, PMID:20434336]


systematic_name: M25919
exact_source: GO:0071817
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071817
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that contains the proteins MMS19, MIP18 and XPD, localizes to mitotic spindle during mitosis, and is required for proper chromosome segregation. [GOC:sp, PMID:20797633]


systematic_name: M40609
exact_source: GO:0071953
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071953
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An supramolecular fiber that consists of an insoluble core of polymerized tropoelastin monomers and a surrounding mantle of microfibrils. Elastic fibers provide elasticity and recoiling to tissues and organs, and maintain structural integrity against mechanical strain. [GOC:BHF, GOC:mah, PMID:20236620]


systematic_name: M25920
exact_source: GO:0071986
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0071986
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A vacuolar membrane-anchored guanine nucleotide exchange factor (GEF) complex for the Rag GTPases (Gtr1-Gtr2 GTPase complex GO:1990131) in TORC1 signaling pathway. In human, Ragulator is comprised of the membrane anchor subunit LAMTOR1 (Meh1p in S. cerevisiae, Lam1 in S. pombe), a GEF subunit LAMTOR2 ( Slm4 in S. cerevisiae , Lam2 in S. pombe ) , LAMTOR3 (no S. cerevisiae ortholog identified, Lam3 in S. pombe) , LAMTOR4 (no S. cerevisiae ortholog identified, Lam4 in S. pombe), and LAMTOR5 (no S. cerevisiae or S. pombe ortholog identified). [GOC:vw, PMID:15989961, PMID:16732272, PMID:19177150, PMID:19748353, PMID:20381137, PMID:22980980, PMID:29199950]


systematic_name: M25921
exact_source: GO:0072357
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072357
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein serine/threonine phosphatase complex that contains a catalytic subunit (PPP1CA, PPP1CB or PPP1CC) and the regulatory subunits PPP1R10 (PNUTS), TOX4 and WDR82, and plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. [GOC:mah, PMID:20516061]


systematic_name: M25922
exact_source: GO:0072379
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072379
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that is involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum. TA membrane proteins, also called type II transmembrane proteins, contain a single C-terminal transmembrane region. Some ER membrane insertion complex subunits are conserved between different species such as mammals and budding yeast. [GOC:mah, PMID:20676083, PMID:20850366]


systematic_name: M25923
exact_source: GO:0072487
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072487
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3. [PMID:16227571, PMID:20018852]


systematic_name: M46945
exact_source: GO:0072534
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072534
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A dense extracellular matrix (ECM) that forms around many neuronal cell bodies and dendrites late in development and is responsible for synaptic stabilization in the adult brain. [GOC:sl, PMID:18364019]


systematic_name: M25924
exact_source: GO:0072546
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072546
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transmembrane protein complex located in the endoplasmic reticulum (ER) involved in the insertion of newly synthesized proteins in the membrane of the ER. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6. [PMID:29242231, PMID:30415835, PMID:32459176]


systematic_name: M48595
exact_source: GO:0072558
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072558
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An inflammasome complex that consists of two components, NLRP1 (NALP1) and caspase-1 or caspase-5. The exact mechanisms of NLRP1 activation remain obscure, but potassium ion efflux appears to be essential. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]


systematic_name: M25925
exact_source: GO:0072559
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072559
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An inflammasome complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. [GOC:add, GOC:BHF, GOC:vp, PMID:20303873]


systematic_name: M17273
exact_source: GO:0072562
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072562
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A phospholipid microvesicle that is derived from any of several cell types, such as platelets, blood cells, endothelial cells, or others, and contains membrane receptors as well as other proteins characteristic of the parental cell. Microparticles are heterogeneous in size, and are characterized as microvesicles free of nucleic acids. [GOC:BHF, GOC:mah, PMID:16373184]


systematic_name: M25926
exact_source: GO:0072588
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072588
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonucleoprotein complex that contains an RNA of the box H/ACA type and the four core proteins dyskerin, NOP10, NHP2, and GAR1 (human protein nomenclature). RNA pseudouridylation (isomerization of uridine to pseudouridine) is the major, and most likely the ancestral, function of H/ACA RNPs. Pseudouridylation targets include both large and small ribosomal RNAs (rRNAs), and small nuclear RNA (U2 snRNA). In addition to these catalytic H/ACA RNPs, a less abundant but more diverse class of structural H/ACA RNPs exists, which does not have pseudouridylation activity. These include the vertebrate telomerase RNP complex. [GOC:BHF, GOC:BHF_telomerase, GOC:jbu, GOC:krc, GOC:mah, GOC:vw, PMID:17284456, PMID:20227365, PMID:25590339]


systematic_name: M25927
exact_source: GO:0072669
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072669
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that catalyzes the ligation of cleaved pre-tRNAs by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. [GOC:sp, PMID:21311021]


systematic_name: M17132
exact_source: GO:0072686
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072686
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]


systematic_name: M25928
exact_source: GO:0072687
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0072687
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]


systematic_name: M17638
exact_source: GO:0080008
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0080008
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. [PMID:16792691, PMID:18223036, PMID:18552200]


systematic_name: M25929
exact_source: GO:0089701
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0089701
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point. [GOC:dos, GOC:mah, PMID:15231733, PMID:1538748, PMID:2963698, PMID:8657565]


systematic_name: M48596
exact_source: GO:0090443
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090443
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body. [GOC:vw, PMID:21561862, PMID:22119525]


systematic_name: M17038
exact_source: GO:0090533
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090533
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in). [GOC:BHF]


systematic_name: M25931
exact_source: GO:0090543
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090543
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge. [GOC:pm, PMID:18641129, PMID:22522702]


systematic_name: M25932
exact_source: GO:0090571
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090571
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. [GOC:tb]


systematic_name: M17103
exact_source: GO:0090575
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090575
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]


systematic_name: M25933
exact_source: GO:0090576
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090576
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III. [GOC:tb]


systematic_name: M25934
exact_source: GO:0090661
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090661
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell. [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:22527283]


systematic_name: M17092
exact_source: GO:0090665
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090665
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds. [GOC:pf, PMID:7693675, PMID:8662961]


systematic_name: M25936
exact_source: GO:0090734
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0090734
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix. [GOC:pg]


systematic_name: M46946
exact_source: GO:0097014
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097014
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  All of the contents of a cilium, excluding the plasma membrane surrounding the cilium. [GOC:BHF, GOC:cilia, GOC:dos, PMID:17895364]


systematic_name: M25937
exact_source: GO:0097025
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097025
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions. [GOC:BHF, PMID:17237226]


systematic_name: M17229
exact_source: GO:0097038
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097038
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes. [GOC:bf, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]


systematic_name: M17824
exact_source: GO:0097060
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097060
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, PMID:20410104]


systematic_name: M25938
exact_source: GO:0097136
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097136
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621]


systematic_name: M25939
exact_source: GO:0097165
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097165
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress. [GOC:ans, PMID:10359787, PMID:12865437]


systematic_name: M43133
exact_source: GO:0097179
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097179
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity. [GOC:ans, PMID:6323392]


systematic_name: M43134
exact_source: GO:0097180
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097180
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity. [GOC:ans, PMID:6323392]


systematic_name: M25940
exact_source: GO:0097197
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097197
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities. [GOC:ans, PMID:19709882, PMID:21930792]


systematic_name: M25941
exact_source: GO:0097208
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097208
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant. [GOC:cjm, Wikipedia:Lamellar_granule]


systematic_name: M34357
exact_source: GO:0097224
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097224
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum. [GOC:cjm, MP:0009830]


systematic_name: M17503
exact_source: GO:0097225
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097225
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece. [GOC:cjm, MP:0009831]


systematic_name: M45322
exact_source: GO:0097226
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097226
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum. [GOC:cjm, MP:0009832, PMID:32791035]


systematic_name: M25942
exact_source: GO:0097227
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097227
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity. [GOC:cjm, MP:0009834]


systematic_name: M17483
exact_source: GO:0097228
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097228
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece. [GOC:cjm, MP:0009836]


systematic_name: M25943
exact_source: GO:0097255
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097255
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others. [GOC:mcc, PMID:15766533, PMID:21925213]


systematic_name: M25944
exact_source: GO:0097342
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097342
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more. [GOC:bhm, GOC:mtg_apoptosis, PMID:22265414, PMID:22274400]


systematic_name: M17104
exact_source: GO:0097346
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097346
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair. [GOC:rb, PMID:19355820]


systematic_name: M40610
exact_source: GO:0097356
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097356
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC. [GOC:vw, PMID:21385875, Wikipedia:Perinucleolar_compartment]


systematic_name: M25945
exact_source: GO:0097361
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097361
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity. [GOC:sp, PMID:22678362]


systematic_name: M17782
exact_source: GO:0097381
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097381
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane. [GOC:bj, GOC:krc, GOC:pde, PMID:11826267, PMID:19501669, PMID:2537204, PMID:26574505, PMID:6771304, PMID:7507907]


systematic_name: M25946
exact_source: GO:0097413
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097413
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein. [NIF_Subcellular:sao4933778419]


systematic_name: M25947
exact_source: GO:0097418
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097418
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star. [NIF_Subcellular:nlx_subcell_20090201, NIF_Subcellular:nlx_subcell_20090202, NIF_Subcellular:sao2409833926]


systematic_name: M25948
exact_source: GO:0097422
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097422
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A network of fine tubules in the vicinity of the Golgi complex and around the centriole. [NIF_Subcellular:sao1570660411, NIF_Subcellular:sao694815499, PMID:11896161]


systematic_name: M25949
exact_source: GO:0097427
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097427
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An arrangement of closely apposed microtubules running parallel to each other. [NIF_Subcellular:sao1872343973]


systematic_name: M25950
exact_source: GO:0097431
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097431
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. [GOC:vw]


systematic_name: M17282
exact_source: GO:0097440
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097440
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon. [NIF_Subcellular:sao273773228]


systematic_name: M25952
exact_source: GO:0097441
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097441
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon. [GOC:aruk, GOC:bc, NIF_Subcellular:sao1079900774, PMID:17046728, PMID:22683681]


systematic_name: M25953
exact_source: GO:0097443
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097443
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles. [NIF_Subcellular:sao1028571114]


systematic_name: M25954
exact_source: GO:0097447
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097447
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches. [GOC:aruk, GOC:bc, NIF_Subcellular:sao172297168]


systematic_name: M25955
exact_source: GO:0097449
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097449
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A prolongation or process extending from the soma of an astrocyte and wrapping around neurons. [NIF_Subcellular:sao1630537580]


systematic_name: M25956
exact_source: GO:0097450
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097450
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Terminal process of astrocyte abutting non-neuronal surfaces in the brain. [NIF_Subcellular:sao388182739]


systematic_name: M40611
exact_source: GO:0097457
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097457
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An axon of a hippocampal granule cell, including dentate gyrus granule cell and CA3 granule cell, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal. [NIF_Subcellular:nlx_subcell_100312, PMID:17765709, PMID:20554881, PMID:24336151]


systematic_name: M25957
exact_source: GO:0097470
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097470
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm. [NIF_Subcellular:sao1884931180, PMID:15626493]


systematic_name: M17140
exact_source: GO:0097504
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097504
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA). [GOC:pr, PMID:11031238, PMID:9683623, Wikipedia:Cell_nucleus#Cajal_bodies_and_gems]


systematic_name: M17317
exact_source: GO:0097526
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097526
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP. [GOC:krc, GOC:pr, ISBN:0879695897, PMID:9452384]


systematic_name: M25961
exact_source: GO:0097539
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097539
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium). [GOC:cilia, GOC:kmv, GOC:krc, PMID:22653444, PMID:24231678, PMID:5064817, PMID:5335827]


systematic_name: M17230
exact_source: GO:0097542
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097542
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction. [GOC:cilia, PMID:23970417]


systematic_name: M48597
exact_source: GO:0097545
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097545
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium. [GOC:cilia, GOC:krc, GOC:pr, PMID:5044758, PMID:5664206, Wikipedia:Axoneme]


systematic_name: M17574
exact_source: GO:0097546
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097546
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area. [GOC:cilia, GOC:krc, PMID:22653444]


systematic_name: M25962
exact_source: GO:0097550
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097550
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription. [GOC:di, PMID:22751016]


systematic_name: M43136
exact_source: GO:0097574
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097574
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells. [GOC:pr]


systematic_name: M25964
exact_source: GO:0097651
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097651
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast. [GOC:ha, PMID:24587488]


systematic_name: M45323
exact_source: GO:0097728
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097728
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). [GOC:cilia, PMID:10330409, PMID:22118931]


systematic_name: M25965
exact_source: GO:0097729
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097729
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme). [GOC:cilia, PMID:22118931]


systematic_name: M25966
exact_source: GO:0097730
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097730
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors. [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931]


systematic_name: M25967
exact_source: GO:0097731
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0097731
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme). [GOC:cilia, PMID:22118931]


systematic_name: M25968
exact_source: GO:0098533
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098533
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transmembrane protein complex that functions in ATPase dependent active transport across a membrane. [GOC:dos]


systematic_name: M25969
exact_source: GO:0098536
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098536
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles. [GOC:cilia, GOC:dos, PMID:24075808, PMID:25047614, PMID:5661997]


systematic_name: M17514
exact_source: GO:0098552
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098552
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos]


systematic_name: M48598
exact_source: GO:0098556
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098556
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The side (leaflet) of the rough endoplasmic reticulum membrane that faces the cytoplasm. [GOC:ab, GOC:dos]


systematic_name: M34359
exact_source: GO:0098591
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098591
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:ab, GOC:dos]


systematic_name: M45971
exact_source: GO:0098635
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098635
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any protein complex that is capable of carrying out some part of the process of cell-cell adhesion. [GOC:dos]


systematic_name: M17195
exact_source: GO:0098636
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098636
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. [GOC:dos]


systematic_name: M43137
exact_source: GO:0098637
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098637
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any protein complex that is capable of carrying out some part of the process of cell-matrix adhesion. [GOC:dos]


systematic_name: M45972
exact_source: GO:0098665
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098665
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that is capable of serotonin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16116092]


systematic_name: M25975
exact_source: GO:0098684
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098684
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribbon synapse between a retinal photoreceptor cell (rod or cone) and a retinal bipolar cell. These contain a plate-like synaptic ribbon. [PMID:15626493]


systematic_name: M25976
exact_source: GO:0098685
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098685
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell. [PMID:16399689]


systematic_name: M25977
exact_source: GO:0098686
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098686
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  One of the giant synapses that form between the mossy fiber axons of dentate gyrus granule cells and the large complex spines of CA3 pyramidal cells. It consists of a giant bouton known as the mossy fiber expansion, synapsed to the complex, multiheaded spine (thorny excresence) of a CA3 pyramidal cell. [DOI:10.1002/1096-9861, PMID:13869693, PMID:23264762]


systematic_name: M25978
exact_source: GO:0098688
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098688
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An excitatory synapse formed by the parallel fibers of granule cells synapsing onto the dendrites of Purkinje cells. [PMID:16623829, PMID:3209740]


systematic_name: M40612
exact_source: GO:0098791
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098791
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A compartment that consists of a lumen and an enclosing membrane, and is part of the Golgi apparatus. [GOC:dos]


systematic_name: M17073
exact_source: GO:0098802
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098802
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any protein complex that is part of the plasma membrane and which functions as a signaling receptor. [GOC:dos]


systematic_name: M25984
exact_source: GO:0098831
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098831
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. [GOC:dos]


systematic_name: M25985
exact_source: GO:0098833
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098833
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A specialized region of the plasma membrane and underlying cytoplasm which surround the the active zone, into which synaptic vesicle membranes are recycled following exocytosis. It is especially enriched in endocytic proteins following intense activity. [PMID:17455288]


systematic_name: M25986
exact_source: GO:0098837
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098837
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. [PMID:20820847]


systematic_name: M25987
exact_source: GO:0098839
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098839
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]


systematic_name: M25988
exact_source: GO:0098843
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098843
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A stably positioned site of clathrin adjacent and physically attached to the postsynaptic specialization, which is the site of endocytosis of post-synaptic proteins. [PMID:17880892]


systematic_name: M25989
exact_source: GO:0098845
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098845
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An endosomal compartment that is part of the post-synapse. Only early and recycling endosomes are typically present in the postsynapse. [PMID:20820847]


systematic_name: M43139
exact_source: GO:0098850
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098850
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The component of the synaptic vesicle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]


systematic_name: M40613
exact_source: GO:0098857
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098857
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A membrane region with a lipid composition that is distinct from that of the membrane regions that surround it. [PMID:20044567, PMID:26253820]


systematic_name: M17655
exact_source: GO:0098858
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098858
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cell projection supported by an assembly of actin filaments, and which lacks microtubules. [PMID:15661519]


systematic_name: M45974
exact_source: GO:0098888
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098888
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The component of the presynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]


systematic_name: M25994
exact_source: GO:0098890
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098890
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The component of the postsynaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]


systematic_name: M46947
exact_source: GO:0098892
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098892
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The component of the postsynaptic specialization membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:autophagy, GOC:mf]


systematic_name: M26003
exact_source: GO:0098985
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098985
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A neuron to neuron synapse with a postsynaptic density, that uses glutamate as a neurotransmitter and whose activity results in excitatory postsynaptic potentials. [GOC:dos]


systematic_name: M26004
exact_source: GO:0098992
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0098992
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A dense core vesicle (granule) that is part of a neuron. These vesicles typically contain neuropeptides. They can be found in all parts of neurons, including the soma, dendrites, axonal swellings (varicosities) and synaptic terminals. [GOC:dos, ISBN:978-0-07-181001-2, Wikipedia:Neuropeptide&oldid=713905176]


systematic_name: M26010
exact_source: GO:0099078
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099078
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that is involved in positioning of the lysosome within the cytoplasm and which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN. The BORC complex recruits ARL8 at the cytosolic face of lysosomes and couples them to microtubule plus-end-directed kinesin motors. [GOC:dos, GOC:li, PMID:25898167]


systematic_name: M26011
exact_source: GO:0099080
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099080
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cellular component that consists of an indeterminate number of proteins or macromolecular complexes, organized into a regular, higher-order structure such as a polymer, sheet, network or a fiber. [GOC:dos]


systematic_name: M26013
exact_source: GO:0099091
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099091
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A network of proteins adjacent to the postsynaptic membrane. Its major components include the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:dos]


systematic_name: M26019
exact_source: GO:0099243
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099243
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The component of the synaptic membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. [GOC:dos]


systematic_name: M17119
exact_source: GO:0099503
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099503
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A cytoplasmic, membrane bound vesicle that is capable of fusing to the plasma membrane to release its contents into the extracellular space. [GOC:dos]


systematic_name: M26020
exact_source: GO:0099513
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099513
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits. [GOC:dos]


systematic_name: M26021
exact_source: GO:0099522
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099522
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any (proper) part of the cytosol of a single cell of sufficient size to still be considered cytosol. [GOC:dos]


systematic_name: M45975
exact_source: GO:0099535
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099535
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The extracellular matrix of the perisynaptic space (the extracellular space adjacent to the synapse) and the synaptic cleft. [GOC:dos]


systematic_name: M17085
exact_source: GO:0099568
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099568
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. [GOC:dos]


systematic_name: M45976
exact_source: GO:0099572
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099572
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A network of proteins within and adjacent to the postsynaptic membrane. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [PMID:22046028]


systematic_name: M26026
exact_source: GO:0099634
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099634
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos]


systematic_name: M17262
exact_source: GO:0099738
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0099738
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The complete extent of cell cortex that underlies some some region of the plasma membrane. [GOC:dos]


systematic_name: M26027
exact_source: GO:0101002
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0101002
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Highly exocytosable gelatinase-poor granules found in neutrophils and rich in ficolin-1. Ficolin-1 is released from neutrophil granules by stimulation with fMLP or PMA, and the majority becomes associated with the surface membrane of the cells and can be detected by flow cytometry. [GOC:mec, PMID:19741154]


systematic_name: M45325
exact_source: GO:0101019
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0101019
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonuclease complex that has 3-prime to 5-prime distributive hydrolytic exoribonuclease activity and in some taxa (e.g. yeast) endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured. [PMID:17174896, PMID:20531386, PMID:26726035]


systematic_name: M26029
exact_source: GO:0101031
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0101031
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. [GOC:bhm, PMID:21855797]


systematic_name: M43141
exact_source: GO:0106002
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0106002
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that binds to, and promotes stabilization of, mRNA molecules containing the major coding region instability determinant (mCRD) by bridging the mCRD domain and the poly(A) tail of the mRNA. In human, it consists of CSDE1, HNRPD, PABPC1, PAIP1 and SYNCRIP. [GOC:bhm, PMID:11051545]


systematic_name: M29441
exact_source: GO:0106068
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0106068
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein ligase complex that enables protein sumoylation. Consists of a SUMO-protein transferase and other proteins that may confer substrate specificity of the complex. [PMID:16847351]


systematic_name: M43142
exact_source: GO:0110016
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0110016
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A chromatin remodeling complex that positively regulates histone H3 acetylation, in particular H3K9, by recruiting histone acetyltransferases to rDNA gene regions. Located in the nucleolus where it assembles on RNA Polymerase I (Pol I) and possibly on RNA Polymerase III (Pol III) promoter and coding regions during early G1 phase and activates the post-initiation phases of Pol I transcription. May also activate RNA Polymerase II (Pol II) gene transcription. In mammals, B-WICH contains the WICH complex core of BAZ1B and SMARCA5, additional protein subunits and possibly rRNAs. Although it contains several catalytic subunits it is not clear which functions are carried out by the complex itself. [GOC:bhm, PMID:16603771, PMID:21559432, PMID:23555303, PMID:26044184]


systematic_name: M43143
exact_source: GO:0110142
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0110142
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The cytosolic ubiquinone biosynthesis complex is composed of enzymes and accessory factors of the ubiquinone biosynthesis pathway and enables synthesis of the extremely hydrophobic molecule ubiquinone. In E. coli, the complex is composed of seven proteins: UbiE, F, G, H, I, J and K. [GOC:imk, PMID:27060254, PMID:28927698, PMID:30686758]


systematic_name: M40615
exact_source: GO:0120044
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120044
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The tapered base of the stereocilium adjacent to where it joins the hair cell body. This region contains a rootlet comprised of bundled actin filaments which spans the joint and stabilizes the stereocilium. [GOC:krc, PMID:20170899]


systematic_name: M43144
exact_source: GO:0120099
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120099
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that acts as a chaperone or scaffold for centriolar proteins during the maturation of the procentriole. Some of its members may become integrated into the growing centriole. Examples are the CPAP(CENPJ)-STIL complex, CEP192-PLK4 complex or CEP152-PLK4 complex in vertebrates. [GOC:bhm, PMID:17576815, PMID:18207742, PMID:21059844, PMID:22020124, PMID:24997597]


systematic_name: M26031
exact_source: GO:0120103
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120103
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which assembles on the mother centriole during cilium formation, adjacent and proximal to a centriolar distal appendage. In human, it contains ODF2, CNTRL, NIN, CCDC120c and CCDC68. [GOC:cilia, PMID:23213374, PMID:27818179, PMID:28422092]


systematic_name: M26032
exact_source: GO:0120111
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120111
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  All of the contents of a plasma membrane bounded neuron projection, excluding the plasma membrane surrounding the projection. [GOC:ha]


systematic_name: M26033
exact_source: GO:0120114
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120114
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex containing members of the Like-Sm family of proteins, which includes both the Sm proteins and the Lsm proteins, and which generally form hexameric or heptameric ring structures which bind to RNA. While some of these ring complexes may form independently of RNA, many only form in association with their target RNA. In addition to Lsm-family proteins, many of these complexes contain additional protein members. Members of this family of complexes include the snRNPs which comprise the majority of the spliceosome. Others are involved in the 5' to 3' degradation pathways of mRNAs in the cytoplasm and of unspliced transcripts in the nucleus, as well as other diverse roles. [GOC:bhm, GOC:krc, PMID:19121818, PMID:27627834]


systematic_name: M34361
exact_source: GO:0120115
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120115
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A heteroheptameric, nuclear protein complex composed of Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Lsm8, or orthologs thereof, that selectively binds to snRNAs, in particular U6 or U6atac snRNAs, and also to unspliced transcripts localized within the nucleus. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23221597, PMID:27627834, PMID:28768202]


systematic_name: M45977
exact_source: GO:0120157
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120157
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein kinase complex that is required for the establishment of a cell polarity axis during the cell division cycle. Binds directly to activated CDC42 GTPase and is required for orchestrating a cellular gradient of CDC42. In S. cerevisiae components are: BEM1, CDC24 and CLA4; from worms to vertebrates it contains a PAR6 protein, PAR3 protein and an atypical PKC. [GOC:lnp, PMID:11113154, PMID:18005931, PMID:22500799, PMID:28682236]


systematic_name: M45326
exact_source: GO:0120199
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120199
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The outer segment of a vertebrate cone photoreceptor that contains membrane discs that are contiguous with the ciliary membrane and containing opsin photoreceptor proteins. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]


systematic_name: M45327
exact_source: GO:0120200
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120200
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The outer segment of a vertebrate rod photoreceptor that contains sealed membrane discs that are not connected to the ciliary membrane and containing rhodopsin photoreceptor proteins. [GOC:krc, GOC:pde, PMID:19501669, PMID:26574505, PMID:6771304]


systematic_name: M43145
exact_source: GO:0120293
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0120293
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An aggregation of axonemal dyneins, their specific assembly factors, and broadly-acting chaperones that is located in the cytoplasm. [GOC:krc, PMID:30561330, PMID:32898505, PMID:33263282]


systematic_name: M45328
exact_source: GO:0140092
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140092
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A brain-specific SWI/SNF-type complex that contains eight or nine proteins, including both conserved (core) and nonconserved components; contains the ATPase product of either the SMARCA4/BAF190A/BRG1 gene, the mammalian ortholog of the yeast SNF2 gene, or the SMARCA2/BAF190B/BRM gene, the mammalian ortholog of the Drosophila brm (brahma) gene, or an ortholog of either of these genes. Compared to the neuron-specific nBAF complex (GO:0071565) it does not contain DPF1, DPF3 or SMARCC1 or their orthologs. May contain PB1/BAF180. [GOC:bhm, PMID:12368262, PMID:12620226, PMID:15525990, PMID:17640523, PMID:17920018, PMID:8804307, PMID:8895581]


systematic_name: M40617
exact_source: GO:0140268
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140268
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A contact site between the endoplasmic reticulum membrane and the plasma membrane, structured by bridging complexes. [PMID:23041194, PMID:27955928, PMID:29290560, PMID:29782498, PMID:30012696]


systematic_name: M43146
exact_source: GO:0140275
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140275
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A mitochondrial intermembrane space bridging complex consisting of components of the MICOS complex in the inner mitochondrial membrane, the SAM complex in the outer membrane, a conserved DNAJ protein (human DNAJC11) and Metaxin 1. [PMID:26477565]


systematic_name: M45329
exact_source: GO:0140288
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140288
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A SWI/SNF subcomplex that incorporates two mutually exclusive paralogs, GLTSCR1 (glioma tumor suppressor candidate region gene 1) or GLTSCR1L (GLTSCR1-like), BRD9 (bromodomain-containing 9) and the BAF subunits BAF155, BAF60, SS18, BAF53a, and BRG1/BRM. [PMID:29374058]


systematic_name: M43147
exact_source: GO:0140445
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140445
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A complex of DNA and protein that seals the end of a chromosome. The telomeric repeat DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA and seal the telomeric loop. [PMID:11352055, PMID:30208292]


systematic_name: M48600
exact_source: GO:0140494
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140494
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A vesicular organelle that forms on retraction fibers behind migrating cells and mediates the release of cytoplasmic contents during cell migration. [PMID:25342562, PMID:31371827]


systematic_name: M40618
exact_source: GO:0140513
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140513
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. [GOC:pg]


systematic_name: M48601
exact_source: GO:0140596
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140596
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A large mitochondrial outer membrane translocase complex that mediates transport of proteins into mitochondrial compartments. TOM transports beta-barrel precursors across the outer membrane and the sorting and assembly machinery (SAM complex) inserts them into the target membrane. [PMID:33035511]


systematic_name: M43148
exact_source: GO:0140672
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0140672
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A chromatin remodeling complex that regulates transcription via acetylation primarily of nucleosomal histones H3 and possibly H4. Shares the histone acetylation (HAT) module of GCN5/PCAF-ADA2-ADA3-SGF29 (or orthologs) with the related SAGA complex (GO:0000124). Contains HAT subunits GCN5 or PCAF in a mutually exclusive manner. In addition to the HAT module contains DR1/NC2B, KAT14, MBIP, WDR5, YEATS2 and ZZZ3 or orthologs. Also regulates the activity of non-histone targets and orchestrates mitotic progression by regulating Cyclin A degradation through acetylation. [GOC:bhm, PMID:19936620, PMID:20562830, PMID:28966424]


systematic_name: M40621
exact_source: GO:0150005
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0150005
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active. [GOC:bhm, PMID:16244137, PMID:28710280]


systematic_name: M26036
exact_source: GO:0150034
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0150034
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  That part of an axon close to and including the growth cone or the axon terminus. [GOC:aruk, GOC:bc, PMID:17202468]


systematic_name: M45978
exact_source: GO:0150053
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0150053
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A synapse of a climbing fiber onto the dendrites of a Purkinje cell in cerebellum. The climbing fiber originates from the inferior olivary nucleus of the medulla oblongata. [GOC:aruk, GOC:bc, PMID:19597563, PMID:23811844, PMID:5044254]


systematic_name: M46949
exact_source: GO:0160064
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0160064
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that mediates the insertion of multi-pass transmembrane proteins into endoplasmic reticulum (ER) membrane. Substrates enter via the lateral gate of the Sec61 translocon. The complex comprises the GEL subcomplex (composed of RAB5IF/OPTI and TMCO1), the BOS subcomplex (composed of NCLN/Nicalin, NOMO and TMEM147) and the PAT subcomplex (composed of WDR83OS/Asterix and CCDC47). [PMID:36261522, PMID:36261528]


systematic_name: M48602
exact_source: GO:0160111
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0160111
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A structural network of microtubule inner proteins (MIPs) located inside the lumen of the A tubule of the axonemal microtubule doublet that helps stabilize the A tubule. [GOC:krc, PMID:29430673, PMID:37295417]


systematic_name: M48603
exact_source: GO:0160112
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0160112
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A structural network of microtubule inner proteins (MIPs) located inside the lumen of the B tubule of the axonemal microtubule doublet that helps stabilize the B tubule. [GOC:krc, PMID:29430673, PMID:37295417]


systematic_name: M46950
exact_source: GO:0170014
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0170014
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A complex composed of ANK1, RHCE, RHAG, SLC4A1, EPB42, GYPA, GYPB and AQP1, that functions in the stability and shape of the erythrocyte membrane in human. [PMID:35835865]


systematic_name: M25743
exact_source: GO:0170049
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0170049
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonucleoprotein complex consisting of a box C/D type snRNA and three (Archaea) or four (Eukaryotes) core proteins that have diverse functions, including site-specific methylation of rRNA and processing rRNA. [PMID:28505386, PMID:30254138]


systematic_name: M45979
exact_source: GO:1902493
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902493
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of acetyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:8077207]


systematic_name: M17054
exact_source: GO:1902562
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902562
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of H4 histone acetyltransferase activity. [GOC:bhm, GOC:TermGenie, PMID:23775086]


systematic_name: M17014
exact_source: GO:1902710
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902710
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of GABA receptor activity. Upon binding of gamma-aminobutyric acid (GABA) it transmits the signal from one side of the membrane to the other to initiate a change in cell activity. Major inhibitory receptor in vertebrate brain. Also found in other vertebrate tissues, invertebrates and possibly in plants. Effective benzodiazepine receptor. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]


systematic_name: M46952
exact_source: GO:1902773
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902773
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of GTPase activator activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:16449187]


systematic_name: M17191
exact_source: GO:1902911
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1902911
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of protein kinase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24606918]


systematic_name: M29443
exact_source: GO:1903293
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1903293
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of phosphatase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:24766807]


systematic_name: M26038
exact_source: GO:1903439
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1903439
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of calcitonin family receptor activity. Calcitonin family receptors may form dimers, trimers or tetramers; adrenomedullin and amylin receptors have only been observed as dimers so far. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:10871296, PMID:12037140, PMID:18687416]


systematic_name: M26039
exact_source: GO:1904090
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1904090
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of peptidase inhibitor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:20860624]


systematic_name: M26040
exact_source: GO:1904724
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1904724
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]


systematic_name: M40622
exact_source: GO:1904813
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1904813
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]


systematic_name: M17442
exact_source: GO:1904949
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1904949
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of ATPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9606181]


systematic_name: M43151
exact_source: GO:1905286
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905286
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of serine-type peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18640965]


systematic_name: M48604
exact_source: GO:1905347
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905347
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of endodeoxyribonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]


systematic_name: M45331
exact_source: GO:1905348
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905348
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of endonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18413719]


systematic_name: M29445
exact_source: GO:1905354
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905354
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of exoribonuclease activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:17174896]


systematic_name: M40624
exact_source: GO:1905360
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905360
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of GTPase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:9178006]


systematic_name: M26042
exact_source: GO:1905368
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905368
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of peptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]


systematic_name: M26043
exact_source: GO:1905369
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905369
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of endopeptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]


systematic_name: M46953
exact_source: GO:1905370
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1905370
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex which is capable of serine-type endopeptidase activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:1689240]


systematic_name: M26044
exact_source: GO:1990023
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990023
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The area in the center of the anaphase spindle consisting of microtubules, microtubule bundling factors and kinesin motors where the spindle microtubules from opposite poles overlap in an antiparallel manner. [GOC:mtg_cell_cycle, GOC:vw]


systematic_name: M43153
exact_source: GO:1990062
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990062
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity. [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]


systematic_name: M45332
exact_source: GO:1990071
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990071
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. [GOC:bhm, PMID:20375281, PMID:22669257]


systematic_name: M45333
exact_source: GO:1990072
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990072
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins. [GOC:bhm, PMID:20375281, PMID:22669257]


systematic_name: M26045
exact_source: GO:1990075
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990075
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A plasma membrane region adjacent to the base of eukaryotic cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to regulate ciliary membrane homeostasis. [GOC:cilia, GOC:dr, GOC:krc, PMID:22342749]


systematic_name: M26046
exact_source: GO:1990111
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990111
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity. [GOC:sp, PMID:23706739]


systematic_name: M26047
exact_source: GO:1990124
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990124
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules. [GOC:bf, PMID:15574591, PMID:21915786]


systematic_name: M48605
exact_source: GO:1990130
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990130
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, the GATOR1 complex consists of DEPDC5, NPRL2, and NPRL3. In S. cerevisiae, this complex is referred to as SEACIT and contains the Iml1p, Npr2p, and Npr3p proteins. [GOC:krc, GOC:rb, PMID:21900499, PMID:23723238, PMID:23974112, PMID:25934700, PMID:28199306, PMID:29199950]


systematic_name: M17155
exact_source: GO:1990234
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990234
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). [GOC:bhm, PMID:16540464]


systematic_name: M26049
exact_source: GO:1990246
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990246
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE. [PMID:24231807]


systematic_name: M26050
exact_source: GO:1990316
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990316
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex consisting of Atg1 (or Atg1 homologs e.g. ULK1, ULK2 in mammals) and Atg13 along with other proteins that regulate its function (e.g. Atg17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation. [GOC:bhm, GOC:DOS, GOC:rb, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]


systematic_name: M17513
exact_source: GO:1990351
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990351
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. [GOC:bhm, PMID:15449578]


systematic_name: M17380
exact_source: GO:1990391
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990391
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. [GOC:bhm, PMID:17217467, PMID:20551348, PMID:22749910, PMID:24192350]


systematic_name: M48606
exact_source: GO:1990393
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990393
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity. [PMID:24793695, PMID:24793696]


systematic_name: M26052
exact_source: GO:1990454
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990454
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation. [GOC:ame, PMID:12946355]


systematic_name: M40625
exact_source: GO:1990462
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990462
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the phagophore assembly sites. [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]


systematic_name: M46954
exact_source: GO:1990508
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990508
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8. [GOC:bhm, PMID:12200444]


systematic_name: M43155
exact_source: GO:1990513
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990513
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms. [GOC:bhm, PMID:23229515]


systematic_name: M40627
exact_source: GO:1990531
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990531
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that functions as a phospholipid-translocating P-Type ATPase. [GOC:dph, GOC:rb, PMID:15090616]


systematic_name: M29446
exact_source: GO:1990635
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990635
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The dendrite of the dendritic tree that is closest to the neuronal cell body (the soma). [GOC:aruk, GOC:bc, PMID:16899232]


systematic_name: M26053
exact_source: GO:1990712
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990712
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription. [GOC:BHF, GOC:kom, PMID:25147378]


systematic_name: M26054
exact_source: GO:1990726
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990726
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A conserved, heteroheptameric, cytoplasmic protein complex composed of Lsm1, Lsm2, Lsm3, Lsm4, Lsm5, Lsm6, Lsm7, and Pat1, or orthologs thereof, that shows a strong binding preference for oligoadenylated RNAs over polyadenylated RNAs. May bind further associated proteins. Facilitates the deadenylation-dependent decapping of mRNA in the P-body thereby regulating mRNA decay and subsequent degradation by the 5' to 3' pathway. [GOC:bhm, GOC:krc, PMID:19121818, PMID:23620288, PMID:24139796, PMID:27627834, PMID:28768202]


systematic_name: M26055
exact_source: GO:1990742
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990742
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm. [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles]


systematic_name: M17598
exact_source: GO:1990752
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990752
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end. [GOC:pr]


systematic_name: M45334
exact_source: GO:1990779
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990779
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transmembrane signaling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation. [GOC:bhm, PMID:1730602, PMID:23336709, PMID:25297919]


systematic_name: M26057
exact_source: GO:1990907
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990907
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors. [GOC:bf, GOC:PARL, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]


systematic_name: M17654
exact_source: GO:1990909
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:1990909
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein. [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]


systematic_name: M26058
exact_source: GO:0000014
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000014
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks. [GOC:mah]


systematic_name: M18522
exact_source: GO:0000030
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000030
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai, GOC:cjm]


systematic_name: M26060
exact_source: GO:0000064
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000064
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26061
exact_source: GO:0000099
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000099
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18569
exact_source: GO:0000146
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000146
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A motor activity that generates movement along a microfilament, driven by ATP hydrolysis. [PMID:29716949]


systematic_name: M18857
exact_source: GO:0000149
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000149
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein. [PMID:12642621]


systematic_name: M17955
exact_source: GO:0000217
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000217
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA secondary structure element such as a four-way junction, a bubble, a loop, Y-form DNA, or a double-strand/single-strand junction. [GOC:krc]


systematic_name: M48608
exact_source: GO:0000253
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000253
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+. [EC:1.1.1.270, GOC:mah, PMID:9811880]


systematic_name: M26065
exact_source: GO:0000268
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000268
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a peroxisomal targeting sequence, a sequence of amino acids within a protein that acts as a signal for the localization of a protein into the peroxisome. [GOC:mah, ISBN:0879693568]


systematic_name: M34364
exact_source: GO:0000298
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000298
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues. [EC:3.6.1.10]


systematic_name: M18244
exact_source: GO:0000339
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000339
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule. [GOC:krc]


systematic_name: M26066
exact_source: GO:0000340
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000340
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II. [GOC:krc]


systematic_name: M18636
exact_source: GO:0000400
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000400
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA segment containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. [GOC:krc, ISBN:0815332181, PMID:15563464]


systematic_name: M26068
exact_source: GO:0000405
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000405
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to DNA segment that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA. [GOC:elh, GOC:vw, PMID:16781730]


systematic_name: M26070
exact_source: GO:0000774
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000774
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. [GOC:kd]


systematic_name: M43156
exact_source: GO:0000827
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000827
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown. [GOC:elh, PMID:11311242]


systematic_name: M26072
exact_source: GO:0000900
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000900
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid. [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370]


systematic_name: M18499
exact_source: GO:0000979
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000979
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene. [GOC:pg, GOC:txnOH, PMID:12381658]


systematic_name: M46955
exact_source: GO:0000987
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000987
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. [GOC:txnOH-2018]


systematic_name: M26074
exact_source: GO:0000995
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0000995
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC. RNA polymerase III transcribes genes encoding short RNAs, including tRNAs, 5S rRNA, U6 snRNA, the short ncRNA component of RNases P, the mitochondrial RNA processing (MRP) RNA, the signal recognition particle SRP RNA, and in higher eukaryotes a number of micro and other small RNAs, though there is some variability across species as to whether a given small noncoding RNA is transcribed by RNA polymerase II or RNA polymerase III. [GOC:txnOH-2018, PMID:12381659, PMID:17977614, PMID:20413673, PMID:27068803, Wikipedia:RNA_polymerase_III]


systematic_name: M45980
exact_source: GO:0001006
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001006
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae. [GOC:txnOH, PMID:12381659]


systematic_name: M26076
exact_source: GO:0001016
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001016
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. [GOC:txnOH, GOC:vw, PMID:12381659]


systematic_name: M19190
exact_source: GO:0001046
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001046
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon. [GOC:pg, GOC:txnOH]


systematic_name: M45981
exact_source: GO:0001054
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001054
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]


systematic_name: M40628
exact_source: GO:0001055
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001055
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]


systematic_name: M45982
exact_source: GO:0001056
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001056
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. [GOC:txnOH]


systematic_name: M26083
exact_source: GO:0001091
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001091
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor. [GOC:txnOH, PMID:16858867]


systematic_name: M26084
exact_source: GO:0001094
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001094
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II. [GOC:krc, PMID:16858867]


systematic_name: M18809
exact_source: GO:0001098
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001098
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a component of the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase. [GOC:txnOH]


systematic_name: M34367
exact_source: GO:0001161
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001161
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]


systematic_name: M26086
exact_source: GO:0001162
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001162
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within. [GOC:txnOH]


systematic_name: M34368
exact_source: GO:0001163
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001163
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I. [GOC:txnOH]


systematic_name: M34369
exact_source: GO:0001181
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001181
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3. In all species characterized, RNA polymerase I transcribes a large polycistronic transcript that is processed into several mature rRNAs (3 or 4 depending on the species), including the large subunit rRNA (28S in humans), the small subunit rRNA (18S in humans), as well as one or two additional smaller rRNAs (the 5.8S rRNA in humans). In most species, this large rRNA transcript is the sole product of RNA polymerase I. However there are rare exceptions, such as Trypanosoma brucei, where RNA polymerase I also transcribes certain mRNAs. [GOC:txnOH-2018, PMID:11500378, PMID:17972917, PMID:25346433, PMID:28340337, PMID:28842442, PMID:31358304]


systematic_name: M26087
exact_source: GO:0001216
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001216
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets. [GOC:txnOH-2018]


systematic_name: M29448
exact_source: GO:0001217
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001217
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A DNA-binding transcription factor activity that represses or decreases the transcription of specific gene sets. [GOC:txnOH-2018]


systematic_name: M18371
exact_source: GO:0001221
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001221
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a transcription coregulator, a protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery. [GOC:krc]


systematic_name: M26088
exact_source: GO:0001222
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001222
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a transcription corepressor, a protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery. [GOC:krc]


systematic_name: M18770
exact_source: GO:0001223
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001223
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a transcription coactivator, a protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery. [GOC:krc]


systematic_name: M46956
exact_source: GO:0001409
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001409
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other. [GOC:mcc]


systematic_name: M26090
exact_source: GO:0001517
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001517
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate. [GOC:ai, GOC:hjd]


systematic_name: M26091
exact_source: GO:0001537
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001537
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate. [EC:2.8.2.-, GOC:ai]


systematic_name: M26094
exact_source: GO:0001594
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001594
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. [GOC:mah, PMID:19325074]


systematic_name: M26096
exact_source: GO:0001609
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001609
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah, PMID:9755289]


systematic_name: M19026
exact_source: GO:0001637
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001637
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:mah]


systematic_name: M45337
exact_source: GO:0001648
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001648
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A G protein-coupled receptor activity that is activated by cleavage by a serine protease, exposing a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it. [GOC:mah, PMID:11356985, PMID:33742547]


systematic_name: M14461
exact_source: GO:0001653
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001653
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an extracellular or intracellular peptide to initiate a change in cell activity. [GOC:jl]


systematic_name: M26097
exact_source: GO:0001665
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001665
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein. [EC:2.4.3.3]


systematic_name: M26099
exact_source: GO:0001758
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001758
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal. [EC:1.2.1.36]


systematic_name: M18494
exact_source: GO:0001786
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001786
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine. [ISBN:0198506732, PMID:12000961]


systematic_name: M19126
exact_source: GO:0001846
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001846
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material. [GOC:add, ISBN:0781735149]


systematic_name: M45984
exact_source: GO:0001847
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001847
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:signaling, ISBN:0781735149]


systematic_name: M26101
exact_source: GO:0001849
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001849
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a C1q complex, a component of the classical complement cascade. [GOC:add, ISBN:0781735149]


systematic_name: M26103
exact_source: GO:0001875
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001875
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate an innate immune response. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system. [PMID:14609719, PMID:15379975]


systematic_name: M43158
exact_source: GO:0001882
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001882
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose. [GOC:hjd]


systematic_name: M18468
exact_source: GO:0001968
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001968
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids. [GOC:hjd]


systematic_name: M18010
exact_source: GO:0001972
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0001972
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]


systematic_name: M40630
exact_source: GO:0002046
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0002046
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception. [GOC:hjd]


systematic_name: M26105
exact_source: GO:0002151
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0002151
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a G-quadruplex RNA structure, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad. [PMID:18294969, PMID:18568163, PMID:19330720]


systematic_name: M26106
exact_source: GO:0002162
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0002162
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to dystroglycan, a glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal). [GOC:hjd]


systematic_name: M26107
exact_source: GO:0003680
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003680
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA structure formed by the minor groove of adenine-thymine-rich DNA regions. Examples of proteins having this function are AT-rich interaction domain (ARID)-containing proteins. [GOC:jl, PMID:10545119, PMID:15802641, PMID:26223912, PMID:2670564]


systematic_name: M17106
exact_source: GO:0003682
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003682
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]


systematic_name: M26108
exact_source: GO:0003688
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003688
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. [GOC:curators]


systematic_name: M26109
exact_source: GO:0003689
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003689
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Facilitating the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:16082778]


systematic_name: M45985
exact_source: GO:0003700
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003700
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]


systematic_name: M18238
exact_source: GO:0003707
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003707
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function. [GOC:signaling, PMID:14708019]


systematic_name: M9985
exact_source: GO:0003711
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003711
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function that stimulates the elongation properties of the RNA polymerase during the elongation phase of transcription. A subclass of transcription elongation factors enable the transition from transcription initiation to elongation, while another class rescue stalled RNA polymerases. [GOC:txnOH-2018, PMID:23878398, PMID:28892040]


systematic_name: M26113
exact_source: GO:0003712
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003712
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator]


systematic_name: M19071
exact_source: GO:0003713
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003713
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription coregulator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coactivators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]


systematic_name: M19029
exact_source: GO:0003714
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003714
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]


systematic_name: M26114
exact_source: GO:0003720
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003720
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence. [GOC:krc, PMID:28732250]


systematic_name: M26115
exact_source: GO:0003726
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003726
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule. [GOC:mah, RHEA:10120]


systematic_name: M18154
exact_source: GO:0003729
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003729
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. [GOC:kmv, GOC:pr, SO:0000234]


systematic_name: M11538
exact_source: GO:0003743
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003743
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. [ISBN:0198506732]


systematic_name: M26116
exact_source: GO:0003756
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003756
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins. [EC:5.3.4.1, GOC:vw, Wikipedia:Protein_disulfide-isomerase#Function]


systematic_name: M13226
exact_source: GO:0003774
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003774
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Generation of force resulting in movement, for example along a microfilament or microtubule, or in torque resulting in membrane scission or rotation of a flagellum. The energy required is obtained either from the hydrolysis of a nucleoside triphosphate or by an electrochemical proton gradient (proton-motive force). [GOC:mah, GOC:vw, PMID:11242086, PMID:29716949]


systematic_name: M18964
exact_source: GO:0003777
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003777
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. [PMID:19686686, PMID:32684327, PMID:32842864]


systematic_name: M18340
exact_source: GO:0003796
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003796
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan. [EC:3.2.1.17, PMID:22748813]


systematic_name: M26117
exact_source: GO:0003810
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003810
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: L-glutaminyl-[protein] + L-lysyl-[protein] = [protein]-L-lysyl-N(6)-5-L-glutamyl-[protein] + NH4+. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links. [EC:2.3.2.13]


systematic_name: M18965
exact_source: GO:0003823
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003823
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. Antigen binding by an MHC protein complex allows the antigen to be displayed to a T cell or NK cell. [GOC:jl, ISBN:0198506732, ISBN:0721662544]


systematic_name: M26118
exact_source: GO:0003828
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003828
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R. [EC:2.4.3.8]


systematic_name: M43159
exact_source: GO:0003836
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003836
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R. [EC:2.4.3.4]


systematic_name: M26120
exact_source: GO:0003846
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003846
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol. [PMID:4016575, RHEA:16741]


systematic_name: M26121
exact_source: GO:0003847
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003847
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate. [EC:3.1.1.47]


systematic_name: M26122
exact_source: GO:0003854
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003854
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H+. [EC:1.1.1.145]


systematic_name: M355
exact_source: GO:0003887
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003887
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. [EC:2.7.7.7, GOC:vw, ISBN:0198547684]


systematic_name: M26124
exact_source: GO:0003906
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003906
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). [Wikipedia:AP_endonuclease]


systematic_name: M26125
exact_source: GO:0003916
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003916
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. [GOC:mah, PMID:8811192]


systematic_name: M43160
exact_source: GO:0003925
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003925
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function regulator that cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular processes. Intrinsic GTPase activity returns the G protein to its GDP-bound state. The return to the GDP-bound state can be accelerated by the action of a GTPase-activating protein (GAP). [PMID:16923326, PMID:24470015]


systematic_name: M26127
exact_source: GO:0003945
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003945
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine. [EC:2.4.1.90]


systematic_name: M34373
exact_source: GO:0003953
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003953
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose. [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847]


systematic_name: M18385
exact_source: GO:0003964
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003964
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. [EC:2.7.7.49]


systematic_name: M19037
exact_source: GO:0003993
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003993
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. [EC:3.1.3.2]


systematic_name: M26135
exact_source: GO:0003997
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0003997
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide. [EC:1.3.3.6]


systematic_name: M26139
exact_source: GO:0004024
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004024
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc. [EC:1.1.1.1, GOC:mah]


systematic_name: M45986
exact_source: GO:0004028
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004028
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid. [UM-BBD_enzymeID:e0432]


systematic_name: M43162
exact_source: GO:0004035
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004035
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1]


systematic_name: M46957
exact_source: GO:0004045
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004045
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA. [EC:3.1.1.29]


systematic_name: M26143
exact_source: GO:0004046
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004046
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid. [EC:3.5.1.14]


systematic_name: M18102
exact_source: GO:0004062
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004062
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate. [EC:2.8.2.1]


systematic_name: M26146
exact_source: GO:0004126
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004126
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: cytidine + H+ + H2O = uridine + NH4 and deoxycytidine + H+ + H2O = deoxyuridine + NH4+. [EC:3.5.4.5]


systematic_name: M26147
exact_source: GO:0004128
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004128
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5). [EC:1.6.2.2, ISBN:0198547684]


systematic_name: M18011
exact_source: GO:0004143
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004143
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H+. [GOC:elh, RHEA:10272]


systematic_name: M26148
exact_source: GO:0004169
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004169
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein. [EC:2.4.1.109, GOC:pr]


systematic_name: M6078
exact_source: GO:0004175
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004175
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


systematic_name: M18202
exact_source: GO:0004177
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004177
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837]


systematic_name: M18129
exact_source: GO:0004180
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004180
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


systematic_name: M18179
exact_source: GO:0004181
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004181
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


systematic_name: M18236
exact_source: GO:0004185
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004185
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]


systematic_name: M5822
exact_source: GO:0004197
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004197
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


systematic_name: M19063
exact_source: GO:0004198
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004198
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. [GOC:mah]


systematic_name: M6339
exact_source: GO:0004222
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004222
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


systematic_name: M34375
exact_source: GO:0004298
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004298
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]


systematic_name: M26150
exact_source: GO:0004300
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004300
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 3-hydroxy-fatty acyl-CoA = a enoyl-CoA + H2O. This reaction usually occurs in the reverse direction, leading to the reduction of the double bound of enoyl-CoA in position 2 or 3. Specific reactions catalyzed include: a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O and a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O. [EC:4.2.1.17]


systematic_name: M18313
exact_source: GO:0004303
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004303
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: estradiol-17-beta + NAD(P)+ = estrone + NAD(P)H + H+. The activity can use NAD+ or NADP+ as the acceptor. [EC:1.1.1.62]


systematic_name: M43164
exact_source: GO:0004321
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004321
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+. [EC:2.3.1.86]


systematic_name: M26154
exact_source: GO:0004331
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004331
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate. [EC:3.1.3.46]


systematic_name: M45339
exact_source: GO:0004336
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004336
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46]


systematic_name: M11836
exact_source: GO:0004364
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004364
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. [EC:2.5.1.18]


systematic_name: M46959
exact_source: GO:0004366
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004366
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate. [EC:2.3.1.15]


systematic_name: M34376
exact_source: GO:0004376
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004376
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage. [GOC:ai]


systematic_name: M18442
exact_source: GO:0004386
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004386
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. [GOC:jl]


systematic_name: M26158
exact_source: GO:0004415
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004415
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. [EC:3.2.1.35]


systematic_name: M26160
exact_source: GO:0004439
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004439
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. [RHEA:22764]


systematic_name: M26161
exact_source: GO:0004445
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004445
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56]


systematic_name: M34378
exact_source: GO:0004464
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004464
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). [EC:4.4.1.20, RHEA:17617]


systematic_name: M34379
exact_source: GO:0004465
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004465
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein. [EC:3.1.1.34, GOC:bf]


systematic_name: M18624
exact_source: GO:0004467
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004467
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [RHEA:15421]


systematic_name: M26165
exact_source: GO:0004468
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004468
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine. [EC:2.3.1.32]


systematic_name: M19831
exact_source: GO:0004497
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004497
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water. [ISBN:0198506732]


systematic_name: M26166
exact_source: GO:0004499
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004499
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O. [RHEA:24468]


systematic_name: M10284
exact_source: GO:0004519
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004519
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. [GOC:mah, ISBN:0198547684]


systematic_name: M16353
exact_source: GO:0004520
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004520
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]


systematic_name: M12611
exact_source: GO:0004521
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004521
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks. [GOC:mah, ISBN:0198547684]


systematic_name: M18084
exact_source: GO:0004523
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004523
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. [EC:3.1.26.4]


systematic_name: M19004
exact_source: GO:0004526
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004526
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor. [EC:3.1.26.5]


systematic_name: M15530
exact_source: GO:0004527
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004527
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end. [GOC:mah, ISBN:0198547684]


systematic_name: M26167
exact_source: GO:0004528
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004528
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides. [EC:3.1.4.1]


systematic_name: M19160
exact_source: GO:0004529
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004529
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. [GOC:mah, ISBN:0198547684]


systematic_name: M46961
exact_source: GO:0004530
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004530
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products. [EC:3.1.21.1]


systematic_name: M26169
exact_source: GO:0004532
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004532
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule. [GOC:mah, ISBN:0198547684]


systematic_name: M3657
exact_source: GO:0004536
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004536
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid. [GOC:mah, ISBN:0198547684]


systematic_name: M18187
exact_source: GO:0004550
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004550
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. [EC:2.7.4.6]


systematic_name: M45987
exact_source: GO:0004556
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004556
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. [PMID:12527308]


systematic_name: M48610
exact_source: GO:0004558
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004558
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose. [EC:3.2.1.20]


systematic_name: M26171
exact_source: GO:0004563
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004563
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides. [EC:3.2.1.52]


systematic_name: M26172
exact_source: GO:0004565
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004565
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. [EC:3.2.1.23]


systematic_name: M43167
exact_source: GO:0004568
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004568
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]


systematic_name: M26173
exact_source: GO:0004571
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004571
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide. [GOC:bf, PMID:25092655]


systematic_name: M26174
exact_source: GO:0004576
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004576
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]


systematic_name: M26175
exact_source: GO:0004596
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004596
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein. [GOC:mah, PMID:30054468]


systematic_name: M18209
exact_source: GO:0004602
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004602
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. [EC:1.11.1.9, PMID:36771108]


systematic_name: M18143
exact_source: GO:0004622
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004622
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid + H+ + sn-glycerol 3-phosphocholine. [EC:3.1.1.5]


systematic_name: M18817
exact_source: GO:0004623
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004623
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides. [RHEA:15801]


systematic_name: M26177
exact_source: GO:0004645
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004645
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase. [EC:2.4.1.1]


systematic_name: M18551
exact_source: GO:0004653
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004653
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis. [EC:2.4.1.41, ISBN:0879695595]


systematic_name: M26179
exact_source: GO:0004656
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004656
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2. [EC:1.14.11.2]


systematic_name: M18062
exact_source: GO:0004659
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004659
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). [GOC:mah]


systematic_name: M26180
exact_source: GO:0004661
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004661
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein. [PMID:8621375]


systematic_name: M46962
exact_source: GO:0004668
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004668
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. [PMID:27393304]


systematic_name: M18091
exact_source: GO:0004672
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004672
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]


systematic_name: M18940
exact_source: GO:0004674
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004674
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925]


systematic_name: M19094
exact_source: GO:0004675
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004675
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [EC:2.7.11.30]


systematic_name: M26182
exact_source: GO:0004679
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004679
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP. [GOC:mah]


systematic_name: M18568
exact_source: GO:0004683
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004683
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Calmodulin-dependent catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. [GOC:mah, PMID:11264466]


systematic_name: M46963
exact_source: GO:0004694
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004694
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate. [GOC:mah, InterPro:IPR015516]


systematic_name: M18716
exact_source: GO:0004697
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004697
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol. [EC:2.7.11.13]


systematic_name: M26186
exact_source: GO:0004703
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004703
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate. [GOC:dph]


systematic_name: M26188
exact_source: GO:0004706
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004706
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs). [GOC:bf]


systematic_name: M4513
exact_source: GO:0004707
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004707
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. [GOC:ma, ISBN:0198547684]


systematic_name: M18962
exact_source: GO:0004708
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004708
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. [ISBN:0198547684]


systematic_name: M18500
exact_source: GO:0004709
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004709
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases. [PMID:9561267]


systematic_name: M26189
exact_source: GO:0004711
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004711
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP. [GOC:mah, PMID:9822608]


systematic_name: M5810
exact_source: GO:0004712
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004712
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [GOC:mah]


systematic_name: M6622
exact_source: GO:0004713
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004713
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]


systematic_name: M5106
exact_source: GO:0004714
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004714
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. [EC:2.7.10.1, GOC:mah]


systematic_name: M18321
exact_source: GO:0004715
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004715
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]


systematic_name: M26190
exact_source: GO:0004720
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004720
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide. [EC:1.4.3.13]


systematic_name: M26191
exact_source: GO:0004721
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004721
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684]


systematic_name: M18297
exact_source: GO:0004722
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004722
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate. [GOC:bf]


systematic_name: M26192
exact_source: GO:0004723
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004723
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions. [EC:3.1.3.16, GOC:mah]


systematic_name: M18580
exact_source: GO:0004725
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004725
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48]


systematic_name: M26194
exact_source: GO:0004726
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004726
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate. [EC:3.1.3.48]


systematic_name: M40634
exact_source: GO:0004740
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004740
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate. [EC:2.7.11.2]


systematic_name: M45988
exact_source: GO:0004741
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004741
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + H2O = L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + phosphate. [EC:3.1.3.43]


systematic_name: M26196
exact_source: GO:0004749
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004749
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H+. [EC:2.7.6.1, RHEA:15609]


systematic_name: M26197
exact_source: GO:0004767
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004767
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: H2O + sphingomyelin = ceramide + choline phosphate + H+. [EC:3.1.4.12, RHEA:19253]


systematic_name: M48611
exact_source: GO:0004784
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004784
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide. [EC:1.15.1.1, GOC:vw, PMID:15064408]


systematic_name: M26199
exact_source: GO:0004791
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004791
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. [RHEA:20345]


systematic_name: M18365
exact_source: GO:0004859
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004859
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid. [GOC:ai, GOC:rl]


systematic_name: M18246
exact_source: GO:0004861
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004861
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:mah, GOC:pr]


systematic_name: M18103
exact_source: GO:0004865
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004865
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate. [GOC:dph, GOC:tb]


systematic_name: M19182
exact_source: GO:0004869
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004869
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of a cysteine-type endopeptidase. [GOC:dph, GOC:tb]


systematic_name: M26201
exact_source: GO:0004875
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004875
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446]


systematic_name: M48612
exact_source: GO:0004890
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004890
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. [PMID:8974333]


systematic_name: M3179
exact_source: GO:0004896
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004896
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:add, GOC:mah]


systematic_name: M26205
exact_source: GO:0004904
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004904
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling, PMID:9607096]


systematic_name: M26206
exact_source: GO:0004908
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004908
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response. [GOC:jl]


systematic_name: M19267
exact_source: GO:0004930
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004930
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]


systematic_name: M40635
exact_source: GO:0004931
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004931
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a monoatomic cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane. [GOC:bf, GOC:mah, PMID:9755289]


systematic_name: M18081
exact_source: GO:0004935
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004935
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex. [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]


systematic_name: M26207
exact_source: GO:0004936
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004936
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274]


systematic_name: M26208
exact_source: GO:0004952
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004952
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the neurotransmitter dopamine to initiate a change in cell activity. [GOC:PARL, IUPHAR_GPCR:1282, PMID:21711983]


systematic_name: M26209
exact_source: GO:0004954
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004954
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity. [ISBN:0198506732]


systematic_name: M26212
exact_source: GO:0004969
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004969
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:ai]


systematic_name: M10552
exact_source: GO:0004970
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004970
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [ISBN:0198506732]


systematic_name: M26214
exact_source: GO:0004972
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004972
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages. [GOC:mah, PMID:10049997]


systematic_name: M17885
exact_source: GO:0004984
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004984
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]


systematic_name: M26218
exact_source: GO:0004985
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004985
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein. [GOC:ai, GOC:bf, PMID:20494127]


systematic_name: M10342
exact_source: GO:0004993
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004993
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai]


systematic_name: M26219
exact_source: GO:0004994
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0004994
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28). [GOC:ai, GOC:bf, Wikipedia:Somatostatin]


systematic_name: M19086
exact_source: GO:0005003
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005003
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an ephrin receptor ligand to initiate a change in cell activity. [GOC:mah, PMID:9530499]


systematic_name: M45989
exact_source: GO:0005005
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005005
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a transmembrane ephrin to initiate a change in cell activity. [GOC:mah, PMID:9530499]


systematic_name: M26222
exact_source: GO:0005007
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005007
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a fibroblast growth factor receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah]


systematic_name: M26223
exact_source: GO:0005021
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005021
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. [GOC:mah, GOC:signaling, PMID:19909239]


systematic_name: M29453
exact_source: GO:0005024
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005024
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:mah, GOC:signaling]


systematic_name: M26224
exact_source: GO:0005025
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005025
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals. [GOC:mah, Reactome:R-HSA-170846]


systematic_name: M43170
exact_source: GO:0005030
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005030
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]


systematic_name: M26226
exact_source: GO:0005031
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005031
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function. [GOC:jl, http://lookwayup.com/]


systematic_name: M48613
exact_source: GO:0005034
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005034
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell. [GOC:dph, GOC:tb]


systematic_name: M19031
exact_source: GO:0005035
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005035
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death. [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]


systematic_name: M26227
exact_source: GO:0005041
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005041
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis. [GOC:bf, ISBN:0198506732]


systematic_name: M46964
exact_source: GO:0005042
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005042
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:dph, GOC:signaling, PMID:15960985]


systematic_name: M18245
exact_source: GO:0005044
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005044
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs). [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]


systematic_name: M17958
exact_source: GO:0005048
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005048
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized. [GOC:ai]


systematic_name: M26229
exact_source: GO:0005049
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005049
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein. [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport]


systematic_name: M26230
exact_source: GO:0005068
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005068
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]


systematic_name: M26232
exact_source: GO:0005078
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005078
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently. [PMID:12511654, PMID:15213240, PMID:9405336]


systematic_name: M17485
exact_source: GO:0005085
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005085
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. [GOC:kd, GOC:mah, PMID:23303910, PMID:27218782]


systematic_name: M18132
exact_source: GO:0005095
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005095
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate. [GOC:ai]


systematic_name: M701
exact_source: GO:0005096
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005096
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP. [GOC:mah]


systematic_name: M15583
exact_source: GO:0005102
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005102
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]


systematic_name: M18625
exact_source: GO:0005123
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005123
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD). [GOC:ceb, GOC:rl, PMID:15654015]


systematic_name: M14581
exact_source: GO:0005125
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005125
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The activity of a soluble extracellular gene product that interacts with a receptor to effect a change in the activity of the receptor to control the survival, growth, differentiation and effector function of tissues and cells. [ISBN:0198599471, PMID:11530802]


systematic_name: M18767
exact_source: GO:0005132
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005132
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2). [GOC:ai, GOC:signaling, PMID:17502368]


systematic_name: M18237
exact_source: GO:0005179
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005179
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. [GOC:dph, GOC:mah, ISBN:0198506732]


systematic_name: M19177
exact_source: GO:0005198
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005198
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of a complex. [GOC:mah, GOC:vw]


systematic_name: M18984
exact_source: GO:0005200
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005200
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of a cytoskeletal structure. [GOC:mah]


systematic_name: M12927
exact_source: GO:0005201
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005201
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of the extracellular matrix. [GOC:mah]


systematic_name: M18222
exact_source: GO:0005212
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005212
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The action of a molecule that contributes to the structural integrity of the lens of an eye. [GOC:mah]


systematic_name: M19156
exact_source: GO:0005215
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005215
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. [GOC:ai, GOC:dgf]


systematic_name: M18812
exact_source: GO:0005217
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005217
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26243
exact_source: GO:0005222
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005222
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]


systematic_name: M26244
exact_source: GO:0005223
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005223
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport]


systematic_name: M26245
exact_source: GO:0005225
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005225
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a monoatomic anion by a volume-sensitive channel. A volume-sensitive channel is a channel that responds to changes in the volume of a cell. [GOC:dph, GOC:tb]


systematic_name: M48614
exact_source: GO:0005229
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005229
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, PMID:29236691]


systematic_name: M18911
exact_source: GO:0005230
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005230
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18473
exact_source: GO:0005231
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005231
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential. [GOC:mah, ISBN:0323037070]


systematic_name: M19001
exact_source: GO:0005242
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005242
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself. [GOC:cb, GOC:mah, PMID:14977398]


systematic_name: M19052
exact_source: GO:0005243
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005243
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes. [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M19157
exact_source: GO:0005245
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005245
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:tb, ISBN:0815340729]


systematic_name: M18444
exact_source: GO:0005247
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005247
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18754
exact_source: GO:0005248
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005248
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18703
exact_source: GO:0005249
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005249
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18859
exact_source: GO:0005251
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005251
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow. [GOC:mah, PMID:11343411, PMID:2462513]


systematic_name: M18341
exact_source: GO:0005253
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005253
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the energy-independent passage of a monoatomic anion across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


systematic_name: M48615
exact_source: GO:0005254
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005254
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


systematic_name: M19194
exact_source: GO:0005261
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005261
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the energy-independent passage of monoatomic cations across a lipid bilayer down a concentration gradient. [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


systematic_name: M18977
exact_source: GO:0005267
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005267
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


systematic_name: M19217
exact_source: GO:0005272
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005272
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


systematic_name: M46965
exact_source: GO:0005275
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005275
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


systematic_name: M43171
exact_source: GO:0005280
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005280
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in). [GOC:ai]


systematic_name: M26248
exact_source: GO:0005283
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005283
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in). [GOC:ai]


systematic_name: M48616
exact_source: GO:0005290
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005290
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M45340
exact_source: GO:0005295
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005295
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral L-amino acid(out) + Na+(out) = neutral L-amino acid(in) + Na+(in). [TC:2.A.23.3.1]


systematic_name: M45341
exact_source: GO:0005298
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005298
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in). [TC:2.A.22.2.1]


systematic_name: M18862
exact_source: GO:0005310
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005310
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups. [GOC:ai]


systematic_name: M45342
exact_source: GO:0005313
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005313
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26250
exact_source: GO:0005315
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005315
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of phosphate ions from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]


systematic_name: M26251
exact_source: GO:0005324
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005324
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a long-chain fatty acid from one side of a membrane to the other. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [ISBN:0198506732]


systematic_name: M19111
exact_source: GO:0005326
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005326
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. [GOC:ai, ISBN:0198506732]


systematic_name: M45343
exact_source: GO:0005332
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005332
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) + Cl-(out) = gamma-aminobutyric acid(in) + Na+(in) + Cl(in). [PMID:7589472, PMID:7861179]


systematic_name: M26252
exact_source: GO:0005337
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005337
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. [GOC:ai]


systematic_name: M26253
exact_source: GO:0005338
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005338
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]


systematic_name: M18623
exact_source: GO:0005342
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005342
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage. [ISBN:0198506732]


systematic_name: M18672
exact_source: GO:0005343
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005343
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in). [TC:2.A.28.1.1]


systematic_name: M45991
exact_source: GO:0005346
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005346
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]


systematic_name: M26256
exact_source: GO:0005347
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005347
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other. [GOC:ai]


systematic_name: M46966
exact_source: GO:0005350
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005350
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other. [GOC:ai]


systematic_name: M26257
exact_source: GO:0005351
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005351
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: carbohydrate(out) + H+(out) = carbohydrate(in) + H+(in). [TC:2.A.1.1]


systematic_name: M43172
exact_source: GO:0005353
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005353
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M48617
exact_source: GO:0005368
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005368
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats. [GOC:ai]


systematic_name: M26262
exact_source: GO:0005388
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005388
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(in) = ADP + phosphate + Ca2+(out). [RHEA:18105]


systematic_name: M26263
exact_source: GO:0005402
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005402
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in). [GOC:ai]


systematic_name: M26264
exact_source: GO:0005412
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005412
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). [TC:2.A.21.3.-]


systematic_name: M26265
exact_source: GO:0005416
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005416
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in). [GOC:ai]


systematic_name: M46967
exact_source: GO:0005432
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005432
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in). [GOC:curators, PMID:16371597]


systematic_name: M26267
exact_source: GO:0005436
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005436
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in). [TC:2.A.1.14.6]


systematic_name: M18926
exact_source: GO:0005452
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005452
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). [GOC:mah]


systematic_name: M48618
exact_source: GO:0005462
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005462
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18317
exact_source: GO:0005484
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005484
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion. [GOC:mah, PMID:14570579]


systematic_name: M18012
exact_source: GO:0005496
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005496
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]


systematic_name: M26268
exact_source: GO:0005499
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005499
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3). [GOC:mah, ISBN:0471331309]


systematic_name: M26269
exact_source: GO:0005502
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005502
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A. [PMID:24403072]


systematic_name: M43173
exact_source: GO:0005503
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005503
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A. [GOC:curators]


systematic_name: M18199
exact_source: GO:0005504
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005504
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]


systematic_name: M9182
exact_source: GO:0005516
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005516
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]


systematic_name: M7392
exact_source: GO:0005518
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005518
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]


systematic_name: M18333
exact_source: GO:0005520
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005520
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it. [ISBN:0198506732]


systematic_name: M18450
exact_source: GO:0005521
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005521
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. [GOC:jl, ISBN:0198506732]


systematic_name: M26270
exact_source: GO:0005522
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005522
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin. [ISBN:0721662544]


systematic_name: M18336
exact_source: GO:0005523
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005523
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle. [GOC:curators, ISBN:0815316194]


systematic_name: M18331
exact_source: GO:0005527
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005527
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species. [GOC:jl, ISBN:0198506732]


systematic_name: M18293
exact_source: GO:0005537
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005537
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans. [GOC:jl, ISBN:0192800981]


systematic_name: M14266
exact_source: GO:0005539
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005539
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues. [GOC:jl, ISBN:0198506732]


systematic_name: M18882
exact_source: GO:0005540
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005540
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine. [GOC:jl]


systematic_name: M18301
exact_source: GO:0005542
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005542
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:jl, ISBN:0198506732]


systematic_name: M19021
exact_source: GO:0005543
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005543
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester. [ISBN:0198506732]


systematic_name: M19226
exact_source: GO:0005544
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005544
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium. [GOC:jl]


systematic_name: M18814
exact_source: GO:0005545
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005545
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a phosphatidylinositol, a glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]


systematic_name: M18061
exact_source: GO:0005546
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005546
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions. [GOC:bf, GOC:jl]


systematic_name: M19183
exact_source: GO:0005547
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005547
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions. [GOC:bf, GOC:jl]


systematic_name: M18802
exact_source: GO:0005548
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005548
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester. [GOC:ai, ISBN:0198506732]


systematic_name: M19181
exact_source: GO:0005549
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0005549
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an odorant, any substance capable of stimulating the sense of smell. [GOC:jl, ISBN:0721662544]


systematic_name: M14051
exact_source: GO:0008009
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008009
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria. [GOC:BHF, GOC:rl, PMID:12183377, Wikipedia:Chemokine]


systematic_name: M18805
exact_source: GO:0008028
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008028
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group. [GOC:ai]


systematic_name: M26272
exact_source: GO:0008035
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008035
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE. [GOC:mah]


systematic_name: M26273
exact_source: GO:0008046
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008046
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance. [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666]


systematic_name: M26274
exact_source: GO:0008048
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008048
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration. [GOC:mah]


systematic_name: M26275
exact_source: GO:0008061
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008061
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues. [GOC:jl, ISBN:0198506732]


systematic_name: M18783
exact_source: GO:0008066
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008066
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling]


systematic_name: M18226
exact_source: GO:0008081
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008081
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. [EC:3.1.4.-]


systematic_name: M11386
exact_source: GO:0008083
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008083
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation. [ISBN:0815316194]


systematic_name: M18503
exact_source: GO:0008092
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008092
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton). [GOC:mah]


systematic_name: M18023
exact_source: GO:0008093
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008093
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way. [GOC:mtg_MIT_16mar07, PMID:30323238]


systematic_name: M26277
exact_source: GO:0008097
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008097
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 5S ribosomal RNA, the smallest RNA constituent of a ribosome. [GOC:jl, ISBN:0321000382]


systematic_name: M40640
exact_source: GO:0008121
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008121
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+. [RHEA:11484]


systematic_name: M26279
exact_source: GO:0008131
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008131
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide. [EC:1.4.3.21]


systematic_name: M18797
exact_source: GO:0008134
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008134
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a transcription factor, a protein required to initiate or regulate transcription. [ISBN:0198506732]


systematic_name: M14882
exact_source: GO:0008135
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008135
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Functions during translation by binding to RNA during polypeptide synthesis at the ribosome. [GOC:ai, GOC:vw]


systematic_name: M48619
exact_source: GO:0008137
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008137
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). [RHEA:29091]


systematic_name: M18402
exact_source: GO:0008138
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008138
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]


systematic_name: M18380
exact_source: GO:0008139
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008139
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus. [GOC:ai]


systematic_name: M18049
exact_source: GO:0008143
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008143
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA. [GOC:jl]


systematic_name: M5179
exact_source: GO:0008146
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008146
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. [GOC:curators]


systematic_name: M17928
exact_source: GO:0008173
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008173
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. [GOC:mah]


systematic_name: M26283
exact_source: GO:0008174
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008174
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule. [GOC:mah]


systematic_name: M19112
exact_source: GO:0008175
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008175
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule. [GOC:mah]


systematic_name: M29454
exact_source: GO:0008186
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008186
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction. [GOC:jl]


systematic_name: M26285
exact_source: GO:0008190
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008190
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation. [ISBN:0198506732]


systematic_name: M19121
exact_source: GO:0008191
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008191
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity. [GOC:ai]


systematic_name: M18680
exact_source: GO:0008194
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008194
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule. [InterPro:IPR004224, PMID:11846783]


systematic_name: M19108
exact_source: GO:0008195
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008195
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. [GOC:pr, PMID:25814022, RHEA:27429]


systematic_name: M15815
exact_source: GO:0008201
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008201
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to heparin, a member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:jl, ISBN:0198506732]


systematic_name: M18316
exact_source: GO:0008227
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008227
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph]


systematic_name: M18200
exact_source: GO:0008233
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008233
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]


systematic_name: M1297
exact_source: GO:0008234
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008234
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


systematic_name: M18163
exact_source: GO:0008235
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008235
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml]


systematic_name: M10611
exact_source: GO:0008237
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008237
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]


systematic_name: M18845
exact_source: GO:0008238
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008238
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both. [https://www.ebi.ac.uk/merops/about/glossary.shtml#EXOPEPTIDASE]


systematic_name: M18309
exact_source: GO:0008239
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008239
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]


systematic_name: M18512
exact_source: GO:0008242
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008242
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of non-standard peptide bonds releasing substituted amino acids such as pyroglutamate or cleave isopeptide bonds, such as many deubiquitinating enzymes. [EC:3.4.19.-, PMID:20157488, PMID:9920379]


systematic_name: M34392
exact_source: GO:0008271
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008271
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport]


systematic_name: M26289
exact_source: GO:0008273
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008273
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in). [TC:2.A.19.4.1]


systematic_name: M26290
exact_source: GO:0008296
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008296
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule. [GOC:mah]


systematic_name: M26291
exact_source: GO:0008297
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008297
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule. [GOC:mah]


systematic_name: M17927
exact_source: GO:0008301
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008301
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence. [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758]


systematic_name: M17947
exact_source: GO:0008308
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008308
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, GOC:vw, ISBN:0815340729]


systematic_name: M46969
exact_source: GO:0008309
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008309
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule. [GOC:mah]


systematic_name: M26292
exact_source: GO:0008310
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008310
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule. [GOC:mah, PMID:22562358]


systematic_name: M46970
exact_source: GO:0008311
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008311
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule. [GOC:mah, PMID:22562358]


systematic_name: M26293
exact_source: GO:0008312
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008312
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a 7S RNA, the RNA component of the signal recognition particle (SRP). [GOC:jl, PMID:6181418]


systematic_name: M26294
exact_source: GO:0008318
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008318
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein. [GOC:mah]


systematic_name: M18216
exact_source: GO:0008324
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008324
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of cation from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M34393
exact_source: GO:0008330
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008330
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [GOC:mah]


systematic_name: M19060
exact_source: GO:0008331
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008331
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729, PMID:16382099]


systematic_name: M43174
exact_source: GO:0008349
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008349
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli. [GOC:bf, PMID:11790549]


systematic_name: M26295
exact_source: GO:0008353
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008353
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + RNA polymerase II large subunit CTD heptapeptide repeat (consensus YSPTSPS) = ADP + H+ + phosphorylated RNA polymerase II. [EC:2.7.11.23, GOC:mah, PMID:28248323]


systematic_name: M26296
exact_source: GO:0008373
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008373
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins. [GOC:cjm, PMID:26192491]


systematic_name: M18865
exact_source: GO:0008375
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008375
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar. [ISBN:0198506732]


systematic_name: M17878
exact_source: GO:0008376
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008376
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide. [ISBN:0198506732]


systematic_name: M18584
exact_source: GO:0008378
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008378
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [ISBN:0198506732]


systematic_name: M26298
exact_source: GO:0008381
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008381
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M19168
exact_source: GO:0008391
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008391
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water. [GOC:mah]


systematic_name: M18916
exact_source: GO:0008395
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008395
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]


systematic_name: M29455
exact_source: GO:0008401
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008401
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid. [PMID:19519282, PMID:9250660]


systematic_name: M18526
exact_source: GO:0008408
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008408
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. [GOC:ai]


systematic_name: M17852
exact_source: GO:0008409
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008409
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end. [GOC:ai]


systematic_name: M29456
exact_source: GO:0008410
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008410
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor). [GOC:jl]


systematic_name: M18847
exact_source: GO:0008417
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008417
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid. [GOC:ai]


systematic_name: M26299
exact_source: GO:0008420
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008420
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: RNA polymerase II large subunit CTD heptapeptide repeat--phospho-L-serine/threonine (consensus YSPTSPS) + H2O = RNA polymerase II large subunit + phosphate. [PMID:22622228]


systematic_name: M45346
exact_source: GO:0008422
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008422
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539]


systematic_name: M26301
exact_source: GO:0008429
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008429
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a phosphatidylethanolamine, a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine. [ISBN:0198506732]


systematic_name: M26303
exact_source: GO:0008432
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008432
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family. [GOC:jl]


systematic_name: M26304
exact_source: GO:0008443
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008443
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule. [GOC:jl]


systematic_name: M26305
exact_source: GO:0008467
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008467
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S. [EC:2.8.2.23]


systematic_name: M18875
exact_source: GO:0008484
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008484
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. [GOC:ai]


systematic_name: M26309
exact_source: GO:0008494
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008494
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide. [GOC:ai]


systematic_name: M26310
exact_source: GO:0008499
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008499
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP. [PMID:10212226]


systematic_name: M26311
exact_source: GO:0008503
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008503
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity. [GOC:jl]


systematic_name: M26312
exact_source: GO:0008504
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008504
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other. [GOC:mah]


systematic_name: M29457
exact_source: GO:0008508
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008508
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in). [TC:2.A.28.-.-]


systematic_name: M18578
exact_source: GO:0008509
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008509
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a negatively charged ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M45993
exact_source: GO:0008510
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008510
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in). [TC:2.A.31.2.1]


systematic_name: M18663
exact_source: GO:0008514
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008514
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai]


systematic_name: M43175
exact_source: GO:0008517
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008517
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines. [GOC:ai]


systematic_name: M18196
exact_source: GO:0008519
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008519
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. [PMID:17710640]


systematic_name: M26314
exact_source: GO:0008525
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008525
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. [GOC:ai, ISBN:0198506732]


systematic_name: M26315
exact_source: GO:0008526
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008526
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Removes phosphatidylinositol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. [GOC:krc, PMID:20823909, PMID:24220498, PMID:25797198]


systematic_name: M18738
exact_source: GO:0008527
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008527
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste. [GOC:dph]


systematic_name: M26316
exact_source: GO:0008532
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008532
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R. [EC:2.4.1.149]


systematic_name: M43176
exact_source: GO:0008556
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008556
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). [RHEA:16777]


systematic_name: M34395
exact_source: GO:0008559
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008559
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). [EC:7.6.2.2]


systematic_name: M18318
exact_source: GO:0008568
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008568
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP. [PMID:10910766]


systematic_name: M26318
exact_source: GO:0008569
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008569
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A motor activity that generates movement along a microtubule toward the minus end, driven by ATP hydrolysis. [GOC:mah, GOC:vw, PMID:15659646, PMID:32842864]


systematic_name: M26319
exact_source: GO:0008574
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008574
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864]


systematic_name: M40642
exact_source: GO:0008597
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008597
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase. [GOC:ai]


systematic_name: M26321
exact_source: GO:0008641
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008641
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. [GOC:jl, GOC:mah]


systematic_name: M26323
exact_source: GO:0008821
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008821
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). [EC:3.1.21.10]


systematic_name: M43177
exact_source: GO:0008889
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008889
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. [EC:3.1.4.46]


systematic_name: M26325
exact_source: GO:0008970
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0008970
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate. [EC:3.1.1.32]


systematic_name: M26326
exact_source: GO:0009008
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009008
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a methyl group to a DNA molecule. [GOC:jl, ISBN:0198506732, PMID:7862522]


systematic_name: M5558
exact_source: GO:0009055
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009055
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. [Wikipedia:Electron_transfer]


systematic_name: M26328
exact_source: GO:0009374
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009374
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions. [GOC:jl, ISBN:0198506732]


systematic_name: M26329
exact_source: GO:0009378
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009378
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Unwinding a DNA helix of DNA containing four-way junctions, including Holliday junctions, driven by ATP hydrolysis. [GOC:al, PMID:22723423, PMID:9442895]


systematic_name: M18022
exact_source: GO:0009881
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009881
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation. [GOC:ai, GOC:go_curators]


systematic_name: M46971
exact_source: GO:0009922
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009922
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. [PMID:16564093, PMID:19763486, RHEA:32727]


systematic_name: M18210
exact_source: GO:0009982
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0009982
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a uridine in RNA = a pseudouridine in RNA. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. [GOC:mah, RHEA:48348]


systematic_name: M18037
exact_source: GO:0010181
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010181
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. [GOC:tb]


systematic_name: M18014
exact_source: GO:0010314
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010314
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position. [GOC:bf, GOC:tair_curators]


systematic_name: M26330
exact_source: GO:0010385
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010385
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks. [GOC:imk, PMID:17242155]


systematic_name: M26331
exact_source: GO:0010851
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010851
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and modulates the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]


systematic_name: M45994
exact_source: GO:0010852
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010852
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and decreases the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]


systematic_name: M45995
exact_source: GO:0010853
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010853
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of an enzyme that catalyzes a ring closure reaction. [GOC:dph, GOC:tb]


systematic_name: M18871
exact_source: GO:0010857
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010857
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Calcium-dependent catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. [GOC:dph, GOC:tb]


systematic_name: M48620
exact_source: GO:0010945
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010945
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction:an acyl-coenzyme A or its derivatives + H2O = adenosine 3',5'-bisphosphate + 4'-phosphopantetheine. This reaction can also use coenzyme A as a substrate. [PMID:10922370, PMID:16185196, RHEA:50044]


systematic_name: M26333
exact_source: GO:0010997
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0010997
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. [GOC:BHF, GOC:dph, GOC:tb]


systematic_name: M18654
exact_source: GO:0015020
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015020
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]


systematic_name: M18700
exact_source: GO:0015026
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015026
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity. [GOC:go_curators]


systematic_name: M18223
exact_source: GO:0015036
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015036
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds. [GOC:curators]


systematic_name: M26335
exact_source: GO:0015038
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015038
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor. [GOC:mah]


systematic_name: M26337
exact_source: GO:0015075
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015075
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an ion from one side of a membrane to the other. [GOC:dgf, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M19223
exact_source: GO:0015081
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015081
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of sodium ions (Na+) from one side of a membrane to the other. [GOC:ai, GOC:BHF, RHEA:34963]


systematic_name: M18544
exact_source: GO:0015085
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015085
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. [GOC:dgf, RHEA:29671]


systematic_name: M45347
exact_source: GO:0015093
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015093
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. [ISBN:0198506732]


systematic_name: M18739
exact_source: GO:0015101
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015101
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18067
exact_source: GO:0015103
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015103
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:ai]


systematic_name: M18629
exact_source: GO:0015106
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015106
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-. [GOC:ai]


systematic_name: M18613
exact_source: GO:0015125
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015125
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine. [GOC:ai]


systematic_name: M26344
exact_source: GO:0015129
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015129
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices. [GOC:ai, ISBN:0198506732, RHEA:34987]


systematic_name: M46974
exact_source: GO:0015139
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015139
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle. [GOC:ai, ISBN:0198547684]


systematic_name: M26347
exact_source: GO:0015141
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015141
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other. [ISBN:0198506732]


systematic_name: M26348
exact_source: GO:0015144
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015144
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of carbohydrate from one side of a membrane to the other. [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M45348
exact_source: GO:0015149
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015149
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M29462
exact_source: GO:0015165
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015165
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18955
exact_source: GO:0015166
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015166
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol. [ISBN:0198506732]


systematic_name: M26350
exact_source: GO:0015168
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015168
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. [GOC:ai]


systematic_name: M18337
exact_source: GO:0015171
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015171
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M34397
exact_source: GO:0015172
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015172
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have side chains with a negative charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26351
exact_source: GO:0015173
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015173
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26352
exact_source: GO:0015174
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015174
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have side chains with a positive charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26353
exact_source: GO:0015175
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015175
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of neutral L-amino acids from one side of a membrane to the other. Neutral amino acids have side chains with no charge at pH 7.3. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18123
exact_source: GO:0015179
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015179
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M34398
exact_source: GO:0015180
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015180
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid. [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


systematic_name: M26355
exact_source: GO:0015183
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015183
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid. [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


systematic_name: M26356
exact_source: GO:0015185
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015185
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA). [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


systematic_name: M26357
exact_source: GO:0015186
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015186
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26358
exact_source: GO:0015187
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015187
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid. [GOC:ai]


systematic_name: M34399
exact_source: GO:0015189
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015189
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M34400
exact_source: GO:0015190
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015190
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26360
exact_source: GO:0015193
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015193
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26361
exact_source: GO:0015194
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015194
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid. [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, RHEA:35031]


systematic_name: M45999
exact_source: GO:0015203
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015203
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other. [GOC:ai]


systematic_name: M26362
exact_source: GO:0015204
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015204
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2. [ISBN:0198506732]


systematic_name: M26363
exact_source: GO:0015205
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015205
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. [ISBN:0198506732]


systematic_name: M46975
exact_source: GO:0015207
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015207
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other. [GOC:go_curators]


systematic_name: M34401
exact_source: GO:0015214
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015214
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other. [GOC:ai]


systematic_name: M18846
exact_source: GO:0015215
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015215
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other. [ISBN:0198506732]


systematic_name: M40645
exact_source: GO:0015216
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015216
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other. [GOC:ai]


systematic_name: M40646
exact_source: GO:0015217
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015217
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other. [GOC:ai]


systematic_name: M34402
exact_source: GO:0015220
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015220
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. [GOC:ai]


systematic_name: M45349
exact_source: GO:0015226
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015226
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane. [GOC:ai]


systematic_name: M46000
exact_source: GO:0015234
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015234
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M26370
exact_source: GO:0015245
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015245
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]


systematic_name: M40647
exact_source: GO:0015247
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015247
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of aminophospholipids from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group. [GOC:pg]


systematic_name: M26371
exact_source: GO:0015252
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015252
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


systematic_name: M34403
exact_source: GO:0015254
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015254
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18059
exact_source: GO:0015269
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015269
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient. [GOC:dph, GOC:mtg_transport]


systematic_name: M26372
exact_source: GO:0015271
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015271
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force. [GOC:mah]


systematic_name: M34404
exact_source: GO:0015272
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015272
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. [GOC:cb, GOC:mah]


systematic_name: M26374
exact_source: GO:0015277
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015277
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist. [GOC:mah, PMID:10049997, PMID:8804111]


systematic_name: M26375
exact_source: GO:0015278
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015278
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]


systematic_name: M18870
exact_source: GO:0015279
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015279
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores. [GOC:dph, GOC:tb, PMID:15788710]


systematic_name: M26376
exact_source: GO:0015280
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015280
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. [GOC:mah]


systematic_name: M26377
exact_source: GO:0015288
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015288
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-]


systematic_name: M18878
exact_source: GO:0015291
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015291
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters. [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820]


systematic_name: M45350
exact_source: GO:0015292
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015292
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]


systematic_name: M19009
exact_source: GO:0015293
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015293
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]


systematic_name: M18800
exact_source: GO:0015294
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015294
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in). [GOC:ai]


systematic_name: M18848
exact_source: GO:0015295
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015295
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in). [GOC:ai]


systematic_name: M18063
exact_source: GO:0015296
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015296
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in). [TC:2.A.1.14.-]


systematic_name: M7104
exact_source: GO:0015297
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015297
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out). [GOC:mtg_transport, ISBN:0815340729, PMID:10839820]


systematic_name: M48622
exact_source: GO:0015315
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015315
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + phosphate(in) = organophosphate(in) +  phosphate(out). [TC:2.A.1.4.-]


systematic_name: M43182
exact_source: GO:0015318
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015318
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon. [GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18868
exact_source: GO:0015347
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015347
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner. [GOC:go_curators]


systematic_name: M34405
exact_source: GO:0015349
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015349
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine. [GOC:ai]


systematic_name: M26380
exact_source: GO:0015355
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015355
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism. [GOC:bf, GOC:jl]


systematic_name: M26381
exact_source: GO:0015368
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015368
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in). [TC:2.A.19.-.-]


systematic_name: M19106
exact_source: GO:0015370
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015370
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in). [GOC:ai]


systematic_name: M26382
exact_source: GO:0015373
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015373
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monoatomic anion(out) + Na+(out) = monoatomic anion(in) + Na+(in). [TC:2.A.21.5.-]


systematic_name: M26385
exact_source: GO:0015379
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015379
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in). [TC:2.A.30.1.5]


systematic_name: M45351
exact_source: GO:0015385
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015385
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). [TC:2.A.35.1.1, TC:2.A.36.-.-]


systematic_name: M43183
exact_source: GO:0015386
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015386
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in). [TC:2.A.37.-.-]


systematic_name: M26386
exact_source: GO:0015399
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015399
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy. [GOC:mtg_transport, PMID:31613498]


systematic_name: M40648
exact_source: GO:0015431
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015431
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). [GOC:jl, PMID:1455517, RHEA:19121]


systematic_name: M43184
exact_source: GO:0015453
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015453
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-]


systematic_name: M18124
exact_source: GO:0015464
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015464
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:jl, GOC:signaling]


systematic_name: M34406
exact_source: GO:0015485
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015485
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. [GOC:jl, ISBN:0198506732]


systematic_name: M43185
exact_source: GO:0015501
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015501
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in). [TC:2.A.27.1.1]


systematic_name: M26389
exact_source: GO:0015562
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015562
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M18780
exact_source: GO:0015605
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015605
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds. [GOC:mcc]


systematic_name: M26390
exact_source: GO:0015616
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015616
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Generation of movement along a single- or double-stranded DNA molecule, driven by ATP hydrolysis. [GOC:mah, PMID:16428451, PMID:17631491]


systematic_name: M18310
exact_source: GO:0015643
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015643
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to a toxic substance, a poisonous substance that causes damage to biological systems. [GOC:bf, GOC:curators, GOC:jl, GOC:pr]


systematic_name: M26391
exact_source: GO:0015651
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015651
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. [ISBN:0198506732]


systematic_name: M34407
exact_source: GO:0015658
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015658
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. [GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729]


systematic_name: M46976
exact_source: GO:0015665
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015665
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group. [ISBN:0198506732]


systematic_name: M18069
exact_source: GO:0015923
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015923
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative. [GOC:ai]


systematic_name: M26392
exact_source: GO:0015924
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015924
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides. [GOC:ai]


systematic_name: M26393
exact_source: GO:0015925
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015925
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative. [GOC:ai]


systematic_name: M18136
exact_source: GO:0015926
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015926
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative. [ISBN:0198506732]


systematic_name: M19210
exact_source: GO:0015929
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015929
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides. [ISBN:0721662544]


systematic_name: M1331
exact_source: GO:0015932
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0015932
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other. [GOC:ai]


systematic_name: M46977
exact_source: GO:0016004
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016004
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid. [GOC:ai]


systematic_name: M26395
exact_source: GO:0016015
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016015
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient. [GOC:go_curators]


systematic_name: M26396
exact_source: GO:0016018
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016018
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binding to cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids. [GOC:mb]


systematic_name: M26397
exact_source: GO:0016019
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016019
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a peptidoglycan and transmitting the signal to initiate an innate immune response. [PMID:14698226]


systematic_name: M48623
exact_source: GO:0016167
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016167
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:mah, GOC:signaling]


systematic_name: M26399
exact_source: GO:0016174
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016174
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide. [EC:1.6.3.1, PMID:10401672, PMID:10601291, PMID:11822874, RHEA:11260]


systematic_name: M15021
exact_source: GO:0016209
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016209
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. [ISBN:0198506732]


systematic_name: M8055
exact_source: GO:0016229
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016229
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative. [GOC:mah]


systematic_name: M40649
exact_source: GO:0016251
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016251
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. [GOC:txnOH-2018, PMID:10384286, PMID:10747032, PMID:23442138, PMID:25693126]


systematic_name: M26404
exact_source: GO:0016274
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016274
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine. [GOC:mah, PMID:12351636, PMID:31284549]


systematic_name: M19077
exact_source: GO:0016278
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016278
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue. [GOC:mah]


systematic_name: M48624
exact_source: GO:0016300
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016300
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule. [GOC:mah]


systematic_name: M18231
exact_source: GO:0016301
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016301
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]


systematic_name: M29465
exact_source: GO:0016303
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016303
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H+. [EC:2.7.1.137, RHEA:12709]


systematic_name: M26405
exact_source: GO:0016308
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016308
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H+. [EC:2.7.1.68, RHEA:14425]


systematic_name: M43186
exact_source: GO:0016312
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016312
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate. [GOC:hb]


systematic_name: M34408
exact_source: GO:0016314
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016314
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate. [EC:3.1.3.67]


systematic_name: M29466
exact_source: GO:0016361
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016361
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals. [GOC:mah, PMID:8622651]


systematic_name: M26409
exact_source: GO:0016423
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016423
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + guanosine in tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine. [GOC:go-curators]


systematic_name: M26411
exact_source: GO:0016427
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016427
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine. [GOC:go-curators]


systematic_name: M48626
exact_source: GO:0016428
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016428
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H+. This modification can occur on seversal residues, including cytidine(34), cytidine(40), cytidine(48), and cytidine(49). [RHEA:61468]


systematic_name: M26413
exact_source: GO:0016433
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016433
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine. [GOC:go-curators]


systematic_name: M34409
exact_source: GO:0016434
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016434
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine. [GOC:go-curators]


systematic_name: M3466
exact_source: GO:0016491
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016491
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. [GOC:go_curators]


systematic_name: M26417
exact_source: GO:0016494
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016494
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif. [GOC:signaling, PMID:8662823]


systematic_name: M26418
exact_source: GO:0016502
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016502
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule. [GOC:signaling, ISBN:0198506732]


systematic_name: M26419
exact_source: GO:0016503
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016503
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior. [GOC:hjd, ISBN:0198506732]


systematic_name: M18614
exact_source: GO:0016505
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016505
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Binds to and increases the activity of a peptidase that is involved in the apoptotic process. [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]


systematic_name: M18723
exact_source: GO:0016538
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016538
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins. [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]


systematic_name: M15309
exact_source: GO:0016614
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016614
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M26423
exact_source: GO:0016615
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016615
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate. [GOC:mah, ISBN:0582227089]


systematic_name: M26424
exact_source: GO:0016624
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016624
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide. [GOC:jl]


systematic_name: M10741
exact_source: GO:0016627
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016627
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M18730
exact_source: GO:0016628
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016628
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]


systematic_name: M26425
exact_source: GO:0016634
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016634
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]


systematic_name: M18746
exact_source: GO:0016638
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016638
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M18823
exact_source: GO:0016641
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016641
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule. [GOC:ai]


systematic_name: M15811
exact_source: GO:0016645
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016645
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M18622
exact_source: GO:0016646
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016646
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]


systematic_name: M15170
exact_source: GO:0016651
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016651
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M26427
exact_source: GO:0016653
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016653
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein. [GOC:ai]


systematic_name: M19066
exact_source: GO:0016655
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016655
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. [GOC:ai]


systematic_name: M26428
exact_source: GO:0016661
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016661
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M41802
exact_source: GO:0016662
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016662
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome. [GOC:jl]


systematic_name: M4191
exact_source: GO:0016667
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016667
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M26429
exact_source: GO:0016668
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016668
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. [GOC:jl]


systematic_name: M26430
exact_source: GO:0016670
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016670
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen. [GOC:jl]


systematic_name: M18370
exact_source: GO:0016671
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016671
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. [GOC:jl]


systematic_name: M43187
exact_source: GO:0016675
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016675
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M43188
exact_source: GO:0016679
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016679
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M15214
exact_source: GO:0016684
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016684
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M18671
exact_source: GO:0016701
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016701
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor. [GOC:mah]


systematic_name: M10622
exact_source: GO:0016705
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016705
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. [GOC:mah]


systematic_name: M8499
exact_source: GO:0016706
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016706
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor. [GOC:mah]


systematic_name: M19163
exact_source: GO:0016709
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016709
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


systematic_name: M19039
exact_source: GO:0016712
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016712
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


systematic_name: M26433
exact_source: GO:0016713
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016713
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


systematic_name: M26434
exact_source: GO:0016714
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016714
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


systematic_name: M26435
exact_source: GO:0016715
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016715
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor. [GOC:mah]


systematic_name: M45355
exact_source: GO:0016716
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016716
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor. [GOC:mah]


systematic_name: M26436
exact_source: GO:0016717
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016717
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water. [GOC:mah]


systematic_name: M18474
exact_source: GO:0016723
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016723
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction in which the metal ion is reduced and NAD+ or NADP+ acts as an electron acceptor. [GOC:mah]


systematic_name: M26437
exact_source: GO:0016724
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016724
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor. [GOC:mah]


systematic_name: M26438
exact_source: GO:0016725
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016725
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. [GOC:ai]


systematic_name: M45356
exact_source: GO:0016728
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016728
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group. [GOC:ai]


systematic_name: M18995
exact_source: GO:0016741
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016741
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M26439
exact_source: GO:0016742
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016742
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor). [EC:2.1.2.-, GOC:mah]


systematic_name: M34410
exact_source: GO:0016744
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016744
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M18399
exact_source: GO:0016746
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016746
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M46978
exact_source: GO:0016747
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016747
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). [GOC:jl]


systematic_name: M18564
exact_source: GO:0016755
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016755
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor). [GOC:jl]


systematic_name: M18527
exact_source: GO:0016757
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016757
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M18100
exact_source: GO:0016758
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016758
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor). [GOC:jl]


systematic_name: M19109
exact_source: GO:0016763
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016763
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). [GOC:jl]


systematic_name: M3387
exact_source: GO:0016765
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016765
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M18611
exact_source: GO:0016769
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016769
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M19204
exact_source: GO:0016772
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016772
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M18853
exact_source: GO:0016775
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016775
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor). [GOC:jl]


systematic_name: M18585
exact_source: GO:0016776
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016776
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor). [GOC:jl]


systematic_name: M26440
exact_source: GO:0016778
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016778
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor). [GOC:jl, PMID:1651917]


systematic_name: M18376
exact_source: GO:0016780
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016780
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor). [GOC:jl]


systematic_name: M19961
exact_source: GO:0016782
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016782
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor). [GOC:jl, ISBN:0198506732]


systematic_name: M26441
exact_source: GO:0016783
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016783
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). [GOC:ai, ISBN:0721662544]


systematic_name: M18174
exact_source: GO:0016790
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016790
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. [EC:3.1.2.-]


systematic_name: M26442
exact_source: GO:0016791
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016791
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]


systematic_name: M19142
exact_source: GO:0016796
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016796
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters. [GOC:mah]


systematic_name: M19206
exact_source: GO:0016801
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016801
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively. [GOC:ai, GOC:jl]


systematic_name: M18271
exact_source: GO:0016805
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016805
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of a dipeptide. [https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDASE, PMID:19879002]


systematic_name: M19151
exact_source: GO:0016810
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016810
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. [GOC:jl]


systematic_name: M18089
exact_source: GO:0016813
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016813
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2. [ISBN:0198506732]


systematic_name: M17851
exact_source: GO:0016814
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016814
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2. [ISBN:0198506732]


systematic_name: M4469
exact_source: GO:0016829
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016829
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. [ISBN:0198547684]


systematic_name: M18396
exact_source: GO:0016830
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016830
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]


systematic_name: M18027
exact_source: GO:0016831
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016831
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. [GOC:curators]


systematic_name: M26444
exact_source: GO:0016832
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016832
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. [GOC:curators]


systematic_name: M26445
exact_source: GO:0016833
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016833
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid. [EC:4.1.3.-, GOC:jl]


systematic_name: M26446
exact_source: GO:0016840
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016840
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99). [EC:4.3.-.-]


systematic_name: M26447
exact_source: GO:0016841
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016841
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. [EC:4.3.-.-, GOC:krc]


systematic_name: M26448
exact_source: GO:0016842
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016842
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate. [EC:4.3.-.-, GOC:krc]


systematic_name: M26449
exact_source: GO:0016849
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016849
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. [GOC:jl]


systematic_name: M19150
exact_source: GO:0016853
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016853
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. [ISBN:0198506732]


systematic_name: M18025
exact_source: GO:0016854
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016854
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. [GOC:mah, ISBN:0198506732]


systematic_name: M26450
exact_source: GO:0016857
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016857
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule. [GOC:mah]


systematic_name: M18178
exact_source: GO:0016859
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016859
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers. [GOC:mah, ISBN:0198506732]


systematic_name: M19024
exact_source: GO:0016860
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016860
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears. [EC:5.3.-.-, GOC:curators]


systematic_name: M19174
exact_source: GO:0016861
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016861
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. [GOC:jl]


systematic_name: M18866
exact_source: GO:0016863
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016863
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears. [EC:5.3.3.-, GOC:mah]


systematic_name: M18435
exact_source: GO:0016866
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016866
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a functional group from one position to another within a single molecule. [GOC:mah]


systematic_name: M18764
exact_source: GO:0016868
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016868
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of a phosphate group from one position to another within a single molecule. [GOC:mah]


systematic_name: M819
exact_source: GO:0016874
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016874
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient. [GOC:mah]


systematic_name: M19098
exact_source: GO:0016875
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016875
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.1.-.-, GOC:mah]


systematic_name: M18291
exact_source: GO:0016877
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016877
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.-.-, GOC:mah]


systematic_name: M19175
exact_source: GO:0016878
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016878
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.2.1.-, GOC:mah]


systematic_name: M14478
exact_source: GO:0016879
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016879
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:mah]


systematic_name: M14561
exact_source: GO:0016881
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016881
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [GOC:jl, GOC:mah]


systematic_name: M18621
exact_source: GO:0016884
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016884
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen. [PMID:12360532]


systematic_name: M26451
exact_source: GO:0016885
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016885
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.4.-.-, GOC:jl, GOC:mah]


systematic_name: M26452
exact_source: GO:0016886
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016886
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. [EC:6.5.-.-, GOC:mah]


systematic_name: M19090
exact_source: GO:0016887
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016887
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065]


systematic_name: M17920
exact_source: GO:0016888
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016888
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:ai]


systematic_name: M26453
exact_source: GO:0016889
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016889
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:ai]


systematic_name: M46979
exact_source: GO:0016891
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016891
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters. [GOC:ai]


systematic_name: M26454
exact_source: GO:0016892
external_details_URL: http://amigo.geneontology.org/amigo/term/GO:0016892
source_species_code: HS
contributor: Gene Ontology
contrib_organization: Gene Ontology Consortium
description_brief:
  Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters. [GOC:ai]


