# gene_set_details

systematic_name: M3461
exact_source: GSE1460_2140_200_UP
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from adult blood.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3465
exact_source: GSE1460_2140_200_DN
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus naive CD4 [GeneID=920] T cells from adult blood.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3470
exact_source: GSE1460_2142_200_UP
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from cord blood.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3472
exact_source: GSE1460_2142_200_DN
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from cord blood.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3474
exact_source: GSE1460_2143_200_UP
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from adult blood.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3476
exact_source: GSE1460_2143_200_DN
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] thymocytes versus naive CD4 [GeneID=920] T cells from adult blood.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3488
exact_source: GSE1460_2147_200_DN
source_species_code: HS
GEO_id: GSE1460
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in naive CD4 [GeneID=920] T cells from adult blood versus thymic stromal cells.

description_full:
[cell repeats an earlier one in this file: 402 characters]


systematic_name: M3490
exact_source: GSE14769_1129_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 20 min.

description_full:
  The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-κB, C/EBPδ, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally validated the prediction that the combination of an initiator (NF-κB), an amplifier (C/EBPδ) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately.


systematic_name: M3491
exact_source: GSE14769_1129_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 20 min.

description_full:
  The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-κB, C/EBPδ, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally validated the prediction that the combination of an initiator (NF-κB), an amplifier (C/EBPδ) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately.


systematic_name: M3493
exact_source: GSE14769_1130_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 40 min.

description_full:
  The innate immune system is a two-edged sword; it is absolutely required for host defense against infection, but if left uncontrolled can trigger a plethora of inflammatory diseases. Here we used systems biology approaches to predict and validate a gene regulatory network involving a dynamic interplay between the transcription factors NF-κB, C/EBPδ, and ATF3 that controls inflammatory responses. We mathematically modeled transcriptional regulation of Il6 and Cebpd genes and experimentally validated the prediction that the combination of an initiator (NF-κB), an amplifier (C/EBPδ) and an attenuator (ATF3) forms a regulatory circuit that discriminates between transient and persistent Toll-like receptor 4-induced signals. Our results suggest a mechanism that enables the innate immune system to detect the duration of infection and to respond appropriately.


systematic_name: M3497
exact_source: GSE14769_1130_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 40 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3498
exact_source: GSE14769_1131_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 60 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3499
exact_source: GSE14769_1131_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 60 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3500
exact_source: GSE14769_1132_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 80 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3502
exact_source: GSE14769_1132_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 80 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3503
exact_source: GSE14769_1133_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 120 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3504
exact_source: GSE14769_1133_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 120 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3507
exact_source: GSE14769_1134_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 240 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3508
exact_source: GSE14769_1134_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 240 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3509
exact_source: GSE14769_1135_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3510
exact_source: GSE14769_1135_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3511
exact_source: GSE14769_1136_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of macrophage cells stimulated with LPS (TLR4 agonist) for 20 min versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3513
exact_source: GSE14769_1136_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of macrophage cells stimulated with LPS (TLR4 agonist) for 20 min versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3514
exact_source: GSE14769_1137_200_UP
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of macrophage cells stimulated with LPS (TLR4 agonist) for 40 min versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3517
exact_source: GSE14769_1137_200_DN
source_species_code: MM
GEO_id: GSE14769
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of macrophage cells stimulated with LPS (TLR4 agonist) for 40 min versus macrophage cells stimulated with LPS (TLR4 agonist) for 360 min.

description_full:
[cell repeats an earlier one in this file: 864 characters]


description_brief: Genes up-regulated in comparison of CD2+ plasmacytoid dendritic cells (DC) versus CD2- cells.
systematic_name: M3519
exact_source: GSE15215_1537_200_UP
source_species_code: HS
GEO_id: GSE15215
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Plasmacytoid dendritic cells (pDCs) are key regulators of anti-viral immunity. They rapidly secrete IFN-alpha and cross-present viral antigens thereby launching adaptive immunity. Here we show that activated human pDCs inhibit replication of cancer cells, and kill them in a contact dependent fashion. Expression of CD2 distinguishes two pDC subsets with distinct phenotype and function. Both subsets secrete IFN-alpha and express Granzyme B and TRAIL. CD2high pDCs uniquely express lysozyme and can be found in tonsils and in tumors. Both subsets launch recall T cell response. However, CD2high pDCs secrete higher levels of IL12 p40, express higher levels of co-stimulatory molecule CD80 and are more efficient in triggering proliferation of naïve allogeneic T cells. Thus, human blood pDCs are composed of subsets with specific phenotype and functions.


description_brief: Genes up-regulated in comparison of naive CD8 T cells versus activated CD8 T cells.
systematic_name: M3523
exact_source: GSE15324_1138_200_UP
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Transcription factors that regulate quiescence, proliferation, and homing of lymphocytes are critical for effective immune system function. In the present study, we demonstrated that the transcription factor ELF4 directly activates the tumor suppressor KLF4 downstream of T cell receptor (TCR) signaling to induce cell cycle arrest in naive CD8+ T cells. Elf4- and Klf4-deficient mice accumulated CD8+CD44hi T cells during steady-state conditions and generated more memory T cells after immunization. The homeostatic expansion of CD8+CD44hi T cells in Elf4-null mice resulted in a redistribution of cells to non-lymphoid tissue due to reduced expression of the transcription factor KLF2, and the surface proteins CCR7 and CD62L. This work describes the combinatorial role of lymphocyte-intrinsic factors in the control of T cell homeostasis, activation and homing.


systematic_name: M3526
exact_source: GSE15324_1139_200_UP
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD8 T cells from ELF4 [GeneID=2000] defficient mice versus activated CD8 T cells from ELF4 [GeneID=2000] defficient animals.

description_full:
  Transcription factors that regulate quiescence, proliferation, and homing of lymphocytes are critical for effective immune system function. In the present study, we demonstrated that the transcription factor ELF4 directly activates the tumor suppressor KLF4 downstream of T cell receptor (TCR) signaling to induce cell cycle arrest in naive CD8+ T cells. Elf4- and Klf4-deficient mice accumulated CD8+CD44hi T cells during steady-state conditions and generated more memory T cells after immunization. The homeostatic expansion of CD8+CD44hi T cells in Elf4-null mice resulted in a redistribution of cells to non-lymphoid tissue due to reduced expression of the transcription factor KLF2, and the surface proteins CCR7 and CD62L. This work describes the combinatorial role of lymphocyte-intrinsic factors in the control of T cell homeostasis, activation and homing.


systematic_name: M3527
exact_source: GSE15324_1139_200_DN
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD8 T cells from ELF4 [GeneID=2000] defficient mice versus activated CD8 T cells from ELF4 [GeneID=2000] defficient animals.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3529
exact_source: GSE15324_1140_200_UP
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD8 T cells from ELF4 [GeneID=2000] defficient mice versus those from wild type animals.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3530
exact_source: GSE15324_1140_200_DN
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD8 T cells from ELF4 [GeneID=2000] defficient mice versus those from wild type animals.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3531
exact_source: GSE15324_1141_200_UP
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of activated CD8 T cells from ELF4 [GeneID=2000] defficient mice versus those from wild type animals.

description_full:
[cell repeats an earlier one in this file: 864 characters]


systematic_name: M3533
exact_source: GSE15324_1141_200_DN
source_species_code: MM
GEO_id: GSE15324
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of activated CD8 T cells from ELF4 [GeneID=2000] defficient mice versus those from wild type animals.

description_full:
[cell repeats an earlier one in this file: 864 characters]


description_brief: Genes up-regulated in comparison of regulatory T cell (Treg) versus conventional T cells.
systematic_name: M3534
exact_source: GSE15659_1415_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of three phenotypically and functionally distinct subpopulations: CD45RA+FoxP3low resting Tregs (rTregs) and CD45RA-FoxP3high activated Tregs (aTregs), both of which are suppressive in vitro, and cytokine-secreting CD45RA-FoxP3low non-suppressive T cells. The proportion of the three subpopulations characteristically altered in cord blood, aged individuals, and patients with immunological diseases. Terminally differentiated aTregs rapidly die while rTregs proliferate and convert into aTregs in vitro and in vivo as shown by the transfer of rTregs into NOD-scid-common gamma-chain-knockout mice and by TCR sequence-based T cell clonotype tracing in peripheral blood of normal individuals. Taken together, the dissection of FoxP3+ cells into subsets enables one to analyze Treg differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP3+ subpopulations.


systematic_name: M3536
exact_source: GSE15659_1416_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus PTPRC+ [GeneID=5788] CD4 [GeneID=920] T cells.

description_full:
  Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of three phenotypically and functionally distinct subpopulations: CD45RA+FoxP3low resting Tregs (rTregs) and CD45RA-FoxP3high activated Tregs (aTregs), both of which are suppressive in vitro, and cytokine-secreting CD45RA-FoxP3low non-suppressive T cells. The proportion of the three subpopulations characteristically altered in cord blood, aged individuals, and patients with immunological diseases. Terminally differentiated aTregs rapidly die while rTregs proliferate and convert into aTregs in vitro and in vivo as shown by the transfer of rTregs into NOD-scid-common gamma-chain-knockout mice and by TCR sequence-based T cell clonotype tracing in peripheral blood of normal individuals. Taken together, the dissection of FoxP3+ cells into subsets enables one to analyze Treg differentiation dynamics and interactions in normal and disease states, and to control immune responses through manipulating particular FoxP3+ subpopulations.


systematic_name: M3538
exact_source: GSE15659_1416_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus PTPRC+ [GeneID=5788] CD4 [GeneID=920] T cells.

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3540
exact_source: GSE15659_1417_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus resting regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3542
exact_source: GSE15659_1417_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus resting regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3547
exact_source: GSE15659_1418_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus non-suppressive T cells.

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3549
exact_source: GSE15659_1419_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3550
exact_source: GSE15659_1419_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3551
exact_source: GSE15659_1420_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus PTPRC+ [GeneID=5788] resting regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3552
exact_source: GSE15659_1420_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus PTPRC+ [GeneID=5788] resting regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3553
exact_source: GSE15659_1421_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus non-suppressive T cells.

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3554
exact_source: GSE15659_1421_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus non-suppressive T cells.

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3555
exact_source: GSE15659_1422_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3557
exact_source: GSE15659_1422_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3558
exact_source: GSE15659_1423_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of resting regulatory T cell (Treg) versus non-suppressive T cells.

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3560
exact_source: GSE15659_1423_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of resting regulatory T cell (Treg) versus non-suppressive T cells.

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3561
exact_source: GSE15659_1424_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of resting regulatory T cell (Treg) versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3563
exact_source: GSE15659_1424_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of resting regulatory T cell (Treg) versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3566
exact_source: GSE15659_1425_200_UP
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of non-suppressive T cells versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3567
exact_source: GSE15659_1425_200_DN
source_species_code: HS
GEO_id: GSE15659
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of non-suppressive T cells versus activated regulatory T cell (Treg).

description_full:
[cell repeats an earlier one in this file: 1224 characters]


systematic_name: M3568
exact_source: GSE15733_1142_200_UP
source_species_code: MM
GEO_id: GSE15733
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells from bone marrow versus those from spleen.

description_full:
  CD4+ T lymphocytes are key to immunological memory, but little is known about the lifestyle of memory CD4+ T lymphocytes. We showed that in the memory phase of specific immune responses to antigens, most of the memory CD4+ T lymphocytes relocated into the bone marrow (BM) within 3-8 weeks after their generation, a process involving integrin a2. Antigen-specific memory CD4+ T lymphocytes expressed Ly-6C to a high degree, unlike most splenic CD44hiCD62L- CD4+ T lymphocytes. In adult mice, more than 80% of Ly-6Chi CD44hiCD62L- memory CD4+ T lymphocytes were in the BM. In the BM, they are located next to IL-7-expressing VCAM-1+ stroma cells, and were in a resting state. Upon challenge with antigen, they rapidly expressed cytokines and CD154 and induced the production of high-affinity antibodies, indicating their functional activity in vivo and marking them as professional memory T helper cells


systematic_name: M3569
exact_source: GSE15733_1142_200_DN
source_species_code: MM
GEO_id: GSE15733
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells from bone marrow versus those from spleen.

description_full:
  CD4+ T lymphocytes are key to immunological memory, but little is known about the lifestyle of memory CD4+ T lymphocytes. We showed that in the memory phase of specific immune responses to antigens, most of the memory CD4+ T lymphocytes relocated into the bone marrow (BM) within 3-8 weeks after their generation, a process involving integrin a2. Antigen-specific memory CD4+ T lymphocytes expressed Ly-6C to a high degree, unlike most splenic CD44hiCD62L- CD4+ T lymphocytes. In adult mice, more than 80% of Ly-6Chi CD44hiCD62L- memory CD4+ T lymphocytes were in the BM. In the BM, they are located next to IL-7-expressing VCAM-1+ stroma cells, and were in a resting state. Upon challenge with antigen, they rapidly expressed cytokines and CD154 and induced the production of high-affinity antibodies, indicating their functional activity in vivo and marking them as professional memory T helper cells


systematic_name: M3570
exact_source: GSE15750_1738_200_UP
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those  from mice defficient for TRAF6 [GeneID=7189] at day 6.

description_full:
  CD8 T cells play a crucial role in immunity to infection and cancer. They are maintained in constant numbers, but upon stimulation with antigen undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific populations, followed by the persistence of long-lived memory cells. Although this predictable pattern of a CD8 T cell response is well established, the underlying cellular mechanisms regulating the transition to memory remain undefined. Here we show that TRAF6, an adapter protein in the TNF-receptor (TNFR) and IL-1R/TLR superfamily, regulates CD8 T cell memory development following infection by modulating fatty acid metabolism. We show that mice with a T cell-specific deletion of TRAF6 mount robust primary CD8 T cell effector responses, but have a profound defect in their ability to generate memory. This defect is CD8 T cell intrinsic and is characterized by the disappearance of antigen-specific cells in the weeks following primary immunization. Microarray analyses revealed that TRAF6-deficient CD8 T cells from early timepoints following immunization exhibit altered expression of genes that regulate fatty acid metabolism. Consistent with this, activated CD8 T cells lacking TRAF6 are unable to upregulate mitochondrial β-oxidation in response to growth factor withdrawal in vitro. Treatment with drugs that induce fatty acid oxidation enabled CD8 T cell memory generation in the absence of TRAF6. Remarkably, these treatments also increased CD8 T cell memory in wild type mice, and consequently were able to significantly improve the efficacy of an experimental anti-cancer vaccine.


systematic_name: M3571
exact_source: GSE15750_1738_200_DN
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of wild type CD8 effector T cells at day 6 versus those  from mice defficient for TRAF6 [GeneID=7189] at day 6.

description_full:
  CD8 T cells play a crucial role in immunity to infection and cancer. They are maintained in constant numbers, but upon stimulation with antigen undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific populations, followed by the persistence of long-lived memory cells. Although this predictable pattern of a CD8 T cell response is well established, the underlying cellular mechanisms regulating the transition to memory remain undefined. Here we show that TRAF6, an adapter protein in the TNF-receptor (TNFR) and IL-1R/TLR superfamily, regulates CD8 T cell memory development following infection by modulating fatty acid metabolism. We show that mice with a T cell-specific deletion of TRAF6 mount robust primary CD8 T cell effector responses, but have a profound defect in their ability to generate memory. This defect is CD8 T cell intrinsic and is characterized by the disappearance of antigen-specific cells in the weeks following primary immunization. Microarray analyses revealed that TRAF6-deficient CD8 T cells from early timepoints following immunization exhibit altered expression of genes that regulate fatty acid metabolism. Consistent with this, activated CD8 T cells lacking TRAF6 are unable to upregulate mitochondrial β-oxidation in response to growth factor withdrawal in vitro. Treatment with drugs that induce fatty acid oxidation enabled CD8 T cell memory generation in the absence of TRAF6. Remarkably, these treatments also increased CD8 T cell memory in wild type mice, and consequently were able to significantly improve the efficacy of an experimental anti-cancer vaccine.


systematic_name: M3573
exact_source: GSE15750_1739_200_UP
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of wild type CD8 effector T cells at day 10 versus those  from mice defficient for TRAF6 [GeneID=7189] at day 10.

description_full:
  CD8 T cells play a crucial role in immunity to infection and cancer. They are maintained in constant numbers, but upon stimulation with antigen undergo a developmental program characterized by distinct phases encompassing the expansion and then contraction of antigen-specific populations, followed by the persistence of long-lived memory cells. Although this predictable pattern of a CD8 T cell response is well established, the underlying cellular mechanisms regulating the transition to memory remain undefined. Here we show that TRAF6, an adapter protein in the TNF-receptor (TNFR) and IL-1R/TLR superfamily, regulates CD8 T cell memory development following infection by modulating fatty acid metabolism. We show that mice with a T cell-specific deletion of TRAF6 mount robust primary CD8 T cell effector responses, but have a profound defect in their ability to generate memory. This defect is CD8 T cell intrinsic and is characterized by the disappearance of antigen-specific cells in the weeks following primary immunization. Microarray analyses revealed that TRAF6-deficient CD8 T cells from early timepoints following immunization exhibit altered expression of genes that regulate fatty acid metabolism. Consistent with this, activated CD8 T cells lacking TRAF6 are unable to upregulate mitochondrial β-oxidation in response to growth factor withdrawal in vitro. Treatment with drugs that induce fatty acid oxidation enabled CD8 T cell memory generation in the absence of TRAF6. Remarkably, these treatments also increased CD8 T cell memory in wild type mice, and consequently were able to significantly improve the efficacy of an experimental anti-cancer vaccine.


systematic_name: M3575
exact_source: GSE15750_1739_200_DN
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of wild type CD8 effector T cells at day 10 versus those  from mice defficient for TRAF6 [GeneID=7189] at day 10.

description_full:
[cell repeats an earlier one in this file: 1674 characters]


systematic_name: M3579
exact_source: GSE15750_1740_200_DN
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of wild type CD8 effector T cells at day 6 versus those at day 10.

description_full:
[cell repeats an earlier one in this file: 1674 characters]


systematic_name: M3580
exact_source: GSE15750_1741_200_UP
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of wild type CD8 effector T cells at day 6 versus those  from mice defficient for TRAF6 [GeneID=7189] at day 10.

description_full:
[cell repeats an earlier one in this file: 1674 characters]


systematic_name: M3583
exact_source: GSE15750_1741_200_DN
source_species_code: MM
GEO_id: GSE15750
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of wild type CD8 effector T cells at day 6 versus those  from mice defficient for TRAF6 [GeneID=7189] at day 10.

description_full:
[cell repeats an earlier one in this file: 1674 characters]


systematic_name: M3584
exact_source: GSE15767_1760_200_UP
source_species_code: MM
GEO_id: GSE15767
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of medullary macrophages versus subcapsular sinus (SCS) macrophages.

description_full:
  LN resident macrophages lining the lymphatic sinuses play critical roles in antigen capture and presentation as well as degradation. We used microarray to examine global gene expression profiles to compare SCS and med macrophages to determine the underlying molecular basis of their differential handling of antigens.


systematic_name: M3585
exact_source: GSE15767_1760_200_DN
source_species_code: MM
GEO_id: GSE15767
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of medullary macrophages versus subcapsular sinus (SCS) macrophages.

description_full:
  LN resident macrophages lining the lymphatic sinuses play critical roles in antigen capture and presentation as well as degradation. We used microarray to examine global gene expression profiles to compare SCS and med macrophages to determine the underlying molecular basis of their differential handling of antigens.


description_brief: Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h.
systematic_name: M3587
exact_source: GSE15930_1346_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Differentiation of naive CD8 T cells into cytotoxic effector cells requires three distinct signals- antigen (signal 1), costimulation -B7-1 (signal 2) and cytokine, either interleukin-12 or interferon-a/b (signal 3). Interaction of naive CD8 T cells with antigen and B7-1 programs cell division and proliferation whereas the presence of cytokines- IL-12 or IFNa/b promote survival, differentiation and memory establishment. In the absence of signal 3, the cells interacting with antigen/B7-1 undergo tolerance induction. The objective of this study was to elucidate the mechanisms how the provision of signal 3 promotes differentiation and averts tolerance induction in CD8 T cells. Trichostatin A is a pharmacological agent that inhibits histone deacetylase activity, hence regulating chromatin structure and gene expression and differentiation in many cell types. Gene signature profiles of IL-12, IFNa/b and trichostatin A stimulated cells were compared to elucidate the molecular mechanisms of gene regulation. Oligonucleotide microarray analysis is carried out to determine the extent and molecular nature of the CD8 T cell differentiation program induced by IL-12 or IFNa/b in concert with antigen and B7-1 signal.


systematic_name: M3589
exact_source: GSE15930_1347_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with IL12 .

description_full:
  Differentiation of naive CD8 T cells into cytotoxic effector cells requires three distinct signals- antigen (signal 1), costimulation -B7-1 (signal 2) and cytokine, either interleukin-12 or interferon-a/b (signal 3). Interaction of naive CD8 T cells with antigen and B7-1 programs cell division and proliferation whereas the presence of cytokines- IL-12 or IFNa/b promote survival, differentiation and memory establishment. In the absence of signal 3, the cells interacting with antigen/B7-1 undergo tolerance induction. The objective of this study was to elucidate the mechanisms how the provision of signal 3 promotes differentiation and averts tolerance induction in CD8 T cells. Trichostatin A is a pharmacological agent that inhibits histone deacetylase activity, hence regulating chromatin structure and gene expression and differentiation in many cell types. Gene signature profiles of IL-12, IFNa/b and trichostatin A stimulated cells were compared to elucidate the molecular mechanisms of gene regulation. Oligonucleotide microarray analysis is carried out to determine the extent and molecular nature of the CD8 T cell differentiation program induced by IL-12 or IFNa/b in concert with antigen and B7-1 signal.


systematic_name: M3591
exact_source: GSE15930_1347_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with IL12 .

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3593
exact_source: GSE15930_1348_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3594
exact_source: GSE15930_1348_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 24 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3599
exact_source: GSE15930_1350_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3600
exact_source: GSE15930_1350_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3601
exact_source: GSE15930_1351_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3604
exact_source: GSE15930_1352_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 48 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3608
exact_source: GSE15930_1354_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3610
exact_source: GSE15930_1354_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3612
exact_source: GSE15930_1355_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3613
exact_source: GSE15930_1355_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3614
exact_source: GSE15930_1356_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3619
exact_source: GSE15930_1356_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3620
exact_source: GSE15930_1357_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3622
exact_source: GSE15930_1357_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3623
exact_source: GSE15930_1358_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3626
exact_source: GSE15930_1358_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3627
exact_source: GSE15930_1359_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3628
exact_source: GSE15930_1359_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 24 h versus CD8 T cells at 24 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3629
exact_source: GSE15930_1360_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3631
exact_source: GSE15930_1360_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3633
exact_source: GSE15930_1361_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3635
exact_source: GSE15930_1361_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3636
exact_source: GSE15930_1362_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3638
exact_source: GSE15930_1362_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3639
exact_source: GSE15930_1363_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3640
exact_source: GSE15930_1363_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after stimulation with IL12.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3641
exact_source: GSE15930_1364_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3646
exact_source: GSE15930_1364_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after stimulation with antigen-B7-1.

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3648
exact_source: GSE15930_1365_200_UP
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3653
exact_source: GSE15930_1365_200_DN
source_species_code: MM
GEO_id: GSE15930
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated CD8 T cells at 72 h versus CD8 T cells at 72 h after treatment with trichostatin A (TSA) [PubChem=5562].

description_full:
[cell repeats an earlier one in this file: 1220 characters]


systematic_name: M3655
exact_source: GSE16522_1391_200_UP
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of rested memory CD8 T cells from pmel-1 mice versus rested naive CD8 T cells from pmel-1 mice.

description_full:
  Effector cells for adoptive immunotherapy can be generated by in vitro stimulation of naïve or memory subsets of CD8+ T cells. While the characteristics of CD8+ T cell subsets are well defined, the heritable influence of those populations on their effector cell progeny is not well understood. We studied effector cells generated from naïve or central memory CD8+ T cells and found that they retained distinct gene expression signatures and developmental programs. Effector cells derived from central memory cells tended to retain their CD62L+ phenotype, but also to acquire KLRG1, an indicator of cellular senescence. In contrast, the effector cell progeny of naïve cells displayed reduced terminal differentiation, and, following infusion, they displayed greater expansion, cytokine production, and tumor destruction. These data indicate that effector cells retain a gene expression imprint conferred by their naïve or central memory progenitors, and they suggest a strategy for enhancing cancer immunotherapy.


systematic_name: M3659
exact_source: GSE16522_1391_200_DN
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of rested memory CD8 T cells from pmel-1 mice versus rested naive CD8 T cells from pmel-1 mice.

description_full:
  Effector cells for adoptive immunotherapy can be generated by in vitro stimulation of naïve or memory subsets of CD8+ T cells. While the characteristics of CD8+ T cell subsets are well defined, the heritable influence of those populations on their effector cell progeny is not well understood. We studied effector cells generated from naïve or central memory CD8+ T cells and found that they retained distinct gene expression signatures and developmental programs. Effector cells derived from central memory cells tended to retain their CD62L+ phenotype, but also to acquire KLRG1, an indicator of cellular senescence. In contrast, the effector cell progeny of naïve cells displayed reduced terminal differentiation, and, following infusion, they displayed greater expansion, cytokine production, and tumor destruction. These data indicate that effector cells retain a gene expression imprint conferred by their naïve or central memory progenitors, and they suggest a strategy for enhancing cancer immunotherapy.


systematic_name: M3660
exact_source: GSE16522_1392_200_UP
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus stimulated naive CD8 T cells from pmel-1 mice.

description_full:
  Effector cells for adoptive immunotherapy can be generated by in vitro stimulation of naïve or memory subsets of CD8+ T cells. While the characteristics of CD8+ T cell subsets are well defined, the heritable influence of those populations on their effector cell progeny is not well understood. We studied effector cells generated from naïve or central memory CD8+ T cells and found that they retained distinct gene expression signatures and developmental programs. Effector cells derived from central memory cells tended to retain their CD62L+ phenotype, but also to acquire KLRG1, an indicator of cellular senescence. In contrast, the effector cell progeny of naïve cells displayed reduced terminal differentiation, and, following infusion, they displayed greater expansion, cytokine production, and tumor destruction. These data indicate that effector cells retain a gene expression imprint conferred by their naïve or central memory progenitors, and they suggest a strategy for enhancing cancer immunotherapy.


systematic_name: M3662
exact_source: GSE16522_1392_200_DN
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus stimulated naive CD8 T cells from pmel-1 mice.

description_full:
[cell repeats an earlier one in this file: 1012 characters]


systematic_name: M3663
exact_source: GSE16522_1393_200_UP
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus unstimulated memory CD8 T cells from pmel-1 mice.

description_full:
[cell repeats an earlier one in this file: 1012 characters]


systematic_name: M3664
exact_source: GSE16522_1393_200_DN
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of stimulated memory CD8 T cells from pmel-1 mice versus unstimulated memory CD8 T cells from pmel-1 mice.

description_full:
[cell repeats an earlier one in this file: 1012 characters]


systematic_name: M3666
exact_source: GSE16522_1394_200_UP
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of stimulated naive CD8 T cells from pmel-1 mice versus unstimulated naive CD8 T cells from pmel-1 mice.

description_full:
[cell repeats an earlier one in this file: 1012 characters]


systematic_name: M3667
exact_source: GSE16522_1394_200_DN
source_species_code: MM
GEO_id: GSE16522
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of stimulated naive CD8 T cells from pmel-1 mice versus unstimulated naive CD8 T cells from pmel-1 mice.

description_full:
[cell repeats an earlier one in this file: 1012 characters]


systematic_name: M3668
exact_source: GSE16755_2032_200_UP
source_species_code: HS
GEO_id: GSE16755
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control macrophages versus macrophages treated with interferon alpha.

description_full:
  To study effects of IFNalpha treatment on monocyte-derived macrophages which may influence susceptibility or resistance to HIV.


systematic_name: M3669
exact_source: GSE16755_2032_200_DN
source_species_code: HS
GEO_id: GSE16755
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control macrophages versus macrophages treated with interferon alpha.

description_full:
  To study effects of IFNalpha treatment on monocyte-derived macrophages which may influence susceptibility or resistance to HIV.


systematic_name: M3670
exact_source: GSE17580_1295_200_UP
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of regulatory T cell (Treg) from uninfected mice versus T effector cells from uninfected mice.

description_full:
  Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic helminth infection model S. mansoni to address the impact on the Treg gene repertoire. Before gene expression profiling we first chose to study the localization and antigen-specific suppressive nature of classically defined Treg during infection. Presence of Foxp3+ cells were found especially in the periphery of granulomas and isolated CD4+CD25hiFoxp3+ Treg from infected mice blocked IFN-gamma and IL-10 cytokine secretion from infected CD4+CD25- effector T cells (Teff). Furthermore the gene expression patterns of Treg and Teff showed that in total 474 genes were significantly regulated during chronic schistosomiasis. Upon k-means clustering we identified genes exclusively regulated in all four populations including Foxp3, CD103, GITR, OX40 and CTLA-4: classical Treg markers. During infection however, several non-classical genes were up-regulated solely within the Treg population such as Slpi, Gzmb, Mt1, Fabp5, Nfil3, Socs2, Gpr177 and Klrg1. Using RT-PCR we confirmed aspects of the microarray data and in addition showed that the expression profile of Treg from S. mansoni-infected mice is simultaneously unique and comparative with Treg derived from other infections


systematic_name: M3671
exact_source: GSE17580_1295_200_DN
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of regulatory T cell (Treg) from uninfected mice versus T effector cells from uninfected mice.

description_full:
  Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic helminth infection model S. mansoni to address the impact on the Treg gene repertoire. Before gene expression profiling we first chose to study the localization and antigen-specific suppressive nature of classically defined Treg during infection. Presence of Foxp3+ cells were found especially in the periphery of granulomas and isolated CD4+CD25hiFoxp3+ Treg from infected mice blocked IFN-gamma and IL-10 cytokine secretion from infected CD4+CD25- effector T cells (Teff). Furthermore the gene expression patterns of Treg and Teff showed that in total 474 genes were significantly regulated during chronic schistosomiasis. Upon k-means clustering we identified genes exclusively regulated in all four populations including Foxp3, CD103, GITR, OX40 and CTLA-4: classical Treg markers. During infection however, several non-classical genes were up-regulated solely within the Treg population such as Slpi, Gzmb, Mt1, Fabp5, Nfil3, Socs2, Gpr177 and Klrg1. Using RT-PCR we confirmed aspects of the microarray data and in addition showed that the expression profile of Treg from S. mansoni-infected mice is simultaneously unique and comparative with Treg derived from other infections


systematic_name: M3673
exact_source: GSE17580_1296_200_UP
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of regulatory T cell (Treg) from mice infected with S. mansoni versus T effector cells from the infected mice.

description_full:
  Although several markers have been associated with the characterization of regulatory T cells (Treg) and their function, no studies have investigated the dynamics of their phenotype during infection. Since the necessity of Treg to control immunopathology has been demonstrated, we used the chronic helminth infection model S. mansoni to address the impact on the Treg gene repertoire. Before gene expression profiling we first chose to study the localization and antigen-specific suppressive nature of classically defined Treg during infection. Presence of Foxp3+ cells were found especially in the periphery of granulomas and isolated CD4+CD25hiFoxp3+ Treg from infected mice blocked IFN-gamma and IL-10 cytokine secretion from infected CD4+CD25- effector T cells (Teff). Furthermore the gene expression patterns of Treg and Teff showed that in total 474 genes were significantly regulated during chronic schistosomiasis. Upon k-means clustering we identified genes exclusively regulated in all four populations including Foxp3, CD103, GITR, OX40 and CTLA-4: classical Treg markers. During infection however, several non-classical genes were up-regulated solely within the Treg population such as Slpi, Gzmb, Mt1, Fabp5, Nfil3, Socs2, Gpr177 and Klrg1. Using RT-PCR we confirmed aspects of the microarray data and in addition showed that the expression profile of Treg from S. mansoni-infected mice is simultaneously unique and comparative with Treg derived from other infections


systematic_name: M3674
exact_source: GSE17580_1296_200_DN
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of regulatory T cell (Treg) from mice infected with S. mansoni versus T effector cells from the infected mice.

description_full:
[cell repeats an earlier one in this file: 1480 characters]


systematic_name: M3675
exact_source: GSE17580_1297_200_UP
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of T effector cells from uninfected mice versus T effector cells from mice infected with S. mansoni.

description_full:
[cell repeats an earlier one in this file: 1480 characters]


systematic_name: M3676
exact_source: GSE17580_1297_200_DN
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of T effector cells from uninfected mice versus T effector cells from mice infected with S. mansoni.

description_full:
[cell repeats an earlier one in this file: 1480 characters]


systematic_name: M3677
exact_source: GSE17580_1298_200_UP
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of regulatory T cell (Treg) from uninfected mice versus regulatory T cell (Treg) from mice infected with S. mansoni.

description_full:
[cell repeats an earlier one in this file: 1480 characters]


systematic_name: M3678
exact_source: GSE17580_1298_200_DN
source_species_code: MM
GEO_id: GSE17580
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of regulatory T cell (Treg) from uninfected mice versus regulatory T cell (Treg) from mice infected with S. mansoni.

description_full:
[cell repeats an earlier one in this file: 1480 characters]


systematic_name: M3679
exact_source: GSE17721_1853_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with LPS (TLR4 agonist) at 0.5 h.

description_full:
  mouse primary BMDCs were stimulated with tlr ligands and gene expression changes were profiled on Affymetrix arrays


systematic_name: M3680
exact_source: GSE17721_1853_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with LPS (TLR4 agonist) at 0.5 h.

description_full:
  mouse primary BMDCs were stimulated with tlr ligands and gene expression changes were profiled on Affymetrix arrays


systematic_name: M3683
exact_source: GSE17721_1854_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with LPS (TLR4 agonist) at 1 h.

description_full:
  mouse primary BMDCs were stimulated with tlr ligands and gene expression changes were profiled on Affymetrix arrays


systematic_name: M3685
exact_source: GSE17721_1854_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with LPS (TLR4 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3687
exact_source: GSE17721_1855_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with LPS (TLR4 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3688
exact_source: GSE17721_1855_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with LPS (TLR4 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3689
exact_source: GSE17721_1856_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with LPS (TLR4 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3690
exact_source: GSE17721_1856_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with LPS (TLR4 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3691
exact_source: GSE17721_1857_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with LPS (TLR4 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3692
exact_source: GSE17721_1857_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with LPS (TLR4 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3699
exact_source: GSE17721_1858_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with LPS (TLR4 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3700
exact_source: GSE17721_1858_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with LPS (TLR4 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3701
exact_source: GSE17721_1859_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with LPS (TLR4 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3702
exact_source: GSE17721_1859_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with LPS (TLR4 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3703
exact_source: GSE17721_1860_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with LPS (TLR4 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3704
exact_source: GSE17721_1860_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with LPS (TLR4 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3705
exact_source: GSE17721_1861_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with poly(I:C) (TLR3 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3706
exact_source: GSE17721_1861_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with poly(I:C) (TLR3 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3707
exact_source: GSE17721_1862_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with poly(I:C) (TLR3 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3709
exact_source: GSE17721_1862_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with poly(I:C) (TLR3 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3711
exact_source: GSE17721_1863_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with poly(I:C) (TLR3 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3712
exact_source: GSE17721_1863_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with poly(I:C) (TLR3 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3713
exact_source: GSE17721_1864_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with poly(I:C) (TLR3 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3714
exact_source: GSE17721_1864_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with poly(I:C) (TLR3 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3715
exact_source: GSE17721_1865_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with poly(I:C) (TLR3 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3716
exact_source: GSE17721_1865_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with poly(I:C) (TLR3 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3717
exact_source: GSE17721_1866_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with poly(I:C) (TLR3 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3718
exact_source: GSE17721_1866_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with poly(I:C) (TLR3 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3719
exact_source: GSE17721_1867_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with poly(I:C) (TLR3 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3722
exact_source: GSE17721_1867_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with poly(I:C) (TLR3 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3723
exact_source: GSE17721_1868_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with poly(I:C) (TLR3 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3725
exact_source: GSE17721_1868_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with poly(I:C) (TLR3 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3728
exact_source: GSE17721_1869_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3729
exact_source: GSE17721_1869_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3730
exact_source: GSE17721_1870_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3731
exact_source: GSE17721_1870_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3733
exact_source: GSE17721_1871_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3734
exact_source: GSE17721_1871_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3735
exact_source: GSE17721_1872_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3738
exact_source: GSE17721_1872_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3740
exact_source: GSE17721_1873_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3742
exact_source: GSE17721_1873_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3743
exact_source: GSE17721_1874_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3747
exact_source: GSE17721_1874_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3749
exact_source: GSE17721_1875_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3750
exact_source: GSE17721_1875_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3751
exact_source: GSE17721_1876_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3752
exact_source: GSE17721_1876_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3754
exact_source: GSE17721_1877_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3755
exact_source: GSE17721_1877_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3756
exact_source: GSE17721_1878_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3757
exact_source: GSE17721_1878_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3759
exact_source: GSE17721_1879_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3760
exact_source: GSE17721_1879_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3761
exact_source: GSE17721_1880_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3763
exact_source: GSE17721_1880_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3764
exact_source: GSE17721_1881_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3765
exact_source: GSE17721_1881_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3767
exact_source: GSE17721_1882_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3768
exact_source: GSE17721_1882_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3769
exact_source: GSE17721_1883_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3770
exact_source: GSE17721_1883_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3771
exact_source: GSE17721_1884_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3772
exact_source: GSE17721_1884_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3774
exact_source: GSE17721_1885_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3775
exact_source: GSE17721_1885_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3776
exact_source: GSE17721_1886_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3777
exact_source: GSE17721_1886_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 1 h versus those stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3778
exact_source: GSE17721_1887_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3779
exact_source: GSE17721_1887_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3780
exact_source: GSE17721_1888_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3781
exact_source: GSE17721_1888_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3785
exact_source: GSE17721_1889_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3787
exact_source: GSE17721_1889_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 6 h versus those stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3788
exact_source: GSE17721_1890_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3790
exact_source: GSE17721_1890_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3791
exact_source: GSE17721_1891_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3792
exact_source: GSE17721_1891_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3793
exact_source: GSE17721_1892_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3795
exact_source: GSE17721_1892_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control dendritic cells (DC) at 24 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3796
exact_source: GSE17721_1893_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3797
exact_source: GSE17721_1893_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3798
exact_source: GSE17721_1894_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3800
exact_source: GSE17721_1894_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3801
exact_source: GSE17721_1895_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3802
exact_source: GSE17721_1895_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3803
exact_source: GSE17721_1896_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3807
exact_source: GSE17721_1896_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3808
exact_source: GSE17721_1897_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3809
exact_source: GSE17721_1897_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3811
exact_source: GSE17721_1898_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3813
exact_source: GSE17721_1898_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3814
exact_source: GSE17721_1899_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3817
exact_source: GSE17721_1899_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3818
exact_source: GSE17721_1900_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3819
exact_source: GSE17721_1900_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3820
exact_source: GSE17721_1901_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3821
exact_source: GSE17721_1901_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with poly(I:C) (TLR3 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3822
exact_source: GSE17721_1902_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3823
exact_source: GSE17721_1902_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3824
exact_source: GSE17721_1903_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3826
exact_source: GSE17721_1903_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3830
exact_source: GSE17721_1904_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3831
exact_source: GSE17721_1904_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3832
exact_source: GSE17721_1905_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3833
exact_source: GSE17721_1905_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3834
exact_source: GSE17721_1906_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3836
exact_source: GSE17721_1906_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3838
exact_source: GSE17721_1907_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3839
exact_source: GSE17721_1907_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3840
exact_source: GSE17721_1908_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3841
exact_source: GSE17721_1908_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3842
exact_source: GSE17721_1909_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 16 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3843
exact_source: GSE17721_1909_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 16 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3846
exact_source: GSE17721_1910_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3847
exact_source: GSE17721_1910_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3850
exact_source: GSE17721_1911_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3851
exact_source: GSE17721_1911_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3852
exact_source: GSE17721_1912_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3853
exact_source: GSE17721_1912_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3857
exact_source: GSE17721_1913_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3858
exact_source: GSE17721_1913_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3860
exact_source: GSE17721_1914_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3861
exact_source: GSE17721_1914_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3863
exact_source: GSE17721_1915_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3864
exact_source: GSE17721_1915_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3865
exact_source: GSE17721_1916_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3866
exact_source: GSE17721_1916_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3867
exact_source: GSE17721_1917_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3868
exact_source: GSE17721_1917_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3869
exact_source: GSE17721_1918_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3870
exact_source: GSE17721_1918_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3874
exact_source: GSE17721_1919_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3875
exact_source: GSE17721_1919_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3876
exact_source: GSE17721_1920_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3877
exact_source: GSE17721_1920_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3878
exact_source: GSE17721_1921_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3880
exact_source: GSE17721_1921_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3881
exact_source: GSE17721_1922_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3882
exact_source: GSE17721_1922_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3883
exact_source: GSE17721_1923_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3885
exact_source: GSE17721_1923_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3886
exact_source: GSE17721_1924_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3891
exact_source: GSE17721_1924_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3892
exact_source: GSE17721_1925_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3893
exact_source: GSE17721_1925_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3894
exact_source: GSE17721_1926_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3895
exact_source: GSE17721_1926_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3897
exact_source: GSE17721_1927_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3899
exact_source: GSE17721_1927_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3901
exact_source: GSE17721_1928_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3904
exact_source: GSE17721_1928_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3906
exact_source: GSE17721_1929_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3907
exact_source: GSE17721_1929_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3908
exact_source: GSE17721_1930_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3912
exact_source: GSE17721_1930_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3913
exact_source: GSE17721_1931_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3914
exact_source: GSE17721_1931_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3915
exact_source: GSE17721_1932_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3917
exact_source: GSE17721_1932_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3918
exact_source: GSE17721_1933_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3919
exact_source: GSE17721_1933_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3920
exact_source: GSE17721_1934_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3921
exact_source: GSE17721_1934_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3925
exact_source: GSE17721_1935_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3926
exact_source: GSE17721_1935_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3927
exact_source: GSE17721_1936_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3929
exact_source: GSE17721_1936_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3930
exact_source: GSE17721_1937_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3931
exact_source: GSE17721_1937_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3932
exact_source: GSE17721_1938_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3933
exact_source: GSE17721_1938_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3934
exact_source: GSE17721_1939_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3936
exact_source: GSE17721_1939_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3937
exact_source: GSE17721_1940_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3939
exact_source: GSE17721_1940_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3940
exact_source: GSE17721_1941_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3942
exact_source: GSE17721_1941_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3943
exact_source: GSE17721_1942_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3944
exact_source: GSE17721_1942_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3945
exact_source: GSE17721_1943_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3947
exact_source: GSE17721_1943_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3948
exact_source: GSE17721_1944_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3949
exact_source: GSE17721_1944_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3950
exact_source: GSE17721_1945_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3951
exact_source: GSE17721_1945_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3953
exact_source: GSE17721_1946_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3954
exact_source: GSE17721_1946_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3957
exact_source: GSE17721_1947_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3960
exact_source: GSE17721_1947_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3962
exact_source: GSE17721_1948_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3963
exact_source: GSE17721_1948_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3964
exact_source: GSE17721_1949_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3965
exact_source: GSE17721_1949_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3968
exact_source: GSE17721_1950_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3969
exact_source: GSE17721_1950_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3970
exact_source: GSE17721_1951_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3971
exact_source: GSE17721_1951_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3972
exact_source: GSE17721_1952_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3973
exact_source: GSE17721_1952_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3974
exact_source: GSE17721_1953_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3975
exact_source: GSE17721_1953_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3976
exact_source: GSE17721_1954_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3978
exact_source: GSE17721_1954_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3979
exact_source: GSE17721_1955_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3981
exact_source: GSE17721_1955_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3982
exact_source: GSE17721_1956_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3983
exact_source: GSE17721_1956_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3984
exact_source: GSE17721_1957_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3987
exact_source: GSE17721_1957_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3989
exact_source: GSE17721_1958_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3991
exact_source: GSE17721_1958_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3995
exact_source: GSE17721_1959_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3997
exact_source: GSE17721_1959_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3998
exact_source: GSE17721_1960_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M3999
exact_source: GSE17721_1960_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4003
exact_source: GSE17721_1961_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4004
exact_source: GSE17721_1961_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4005
exact_source: GSE17721_1962_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4006
exact_source: GSE17721_1962_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4007
exact_source: GSE17721_1963_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4009
exact_source: GSE17721_1963_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4010
exact_source: GSE17721_1964_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4011
exact_source: GSE17721_1964_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4012
exact_source: GSE17721_1965_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4015
exact_source: GSE17721_1965_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4016
exact_source: GSE17721_1966_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4017
exact_source: GSE17721_1966_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4018
exact_source: GSE17721_1967_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4020
exact_source: GSE17721_1967_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4021
exact_source: GSE17721_1968_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4022
exact_source: GSE17721_1968_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4024
exact_source: GSE17721_1969_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4025
exact_source: GSE17721_1969_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4026
exact_source: GSE17721_1970_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4027
exact_source: GSE17721_1970_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4028
exact_source: GSE17721_1971_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4030
exact_source: GSE17721_1971_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4031
exact_source: GSE17721_1972_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4032
exact_source: GSE17721_1972_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4033
exact_source: GSE17721_1973_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4036
exact_source: GSE17721_1973_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4037
exact_source: GSE17721_1974_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4039
exact_source: GSE17721_1974_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4040
exact_source: GSE17721_1975_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4041
exact_source: GSE17721_1975_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 1 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 1 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4043
exact_source: GSE17721_1976_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4044
exact_source: GSE17721_1976_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 2 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4048
exact_source: GSE17721_1977_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4049
exact_source: GSE17721_1977_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4050
exact_source: GSE17721_1978_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4055
exact_source: GSE17721_1978_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4056
exact_source: GSE17721_1979_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4057
exact_source: GSE17721_1979_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4058
exact_source: GSE17721_1980_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4059
exact_source: GSE17721_1980_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4060
exact_source: GSE17721_1981_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4062
exact_source: GSE17721_1981_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4063
exact_source: GSE17721_1982_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4066
exact_source: GSE17721_1982_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4067
exact_source: GSE17721_1983_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4069
exact_source: GSE17721_1983_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4070
exact_source: GSE17721_1984_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4073
exact_source: GSE17721_1984_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4074
exact_source: GSE17721_1985_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4075
exact_source: GSE17721_1985_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4079
exact_source: GSE17721_1986_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4080
exact_source: GSE17721_1986_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 0.5 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4081
exact_source: GSE17721_1988_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4083
exact_source: GSE17721_1988_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4084
exact_source: GSE17721_1989_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4087
exact_source: GSE17721_1989_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4089
exact_source: GSE17721_1990_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4091
exact_source: GSE17721_1990_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4096
exact_source: GSE17721_1992_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4097
exact_source: GSE17721_1992_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4098
exact_source: GSE17721_1993_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4099
exact_source: GSE17721_1993_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4101
exact_source: GSE17721_1994_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4102
exact_source: GSE17721_1994_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4103
exact_source: GSE17721_1995_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4104
exact_source: GSE17721_1995_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4105
exact_source: GSE17721_1996_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4108
exact_source: GSE17721_1996_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4110
exact_source: GSE17721_1997_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4111
exact_source: GSE17721_1997_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4112
exact_source: GSE17721_1998_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4114
exact_source: GSE17721_1998_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4115
exact_source: GSE17721_1999_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at all time points versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h only.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4116
exact_source: GSE17721_1999_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at all time points versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h only.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4117
exact_source: GSE17721_2000_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4118
exact_source: GSE17721_2000_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4119
exact_source: GSE17721_2001_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4122
exact_source: GSE17721_2001_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4124
exact_source: GSE17721_2002_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4125
exact_source: GSE17721_2002_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4126
exact_source: GSE17721_2003_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4127
exact_source: GSE17721_2003_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4128
exact_source: GSE17721_2004_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4129
exact_source: GSE17721_2004_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4130
exact_source: GSE17721_2005_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 4 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4131
exact_source: GSE17721_2005_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 4 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4132
exact_source: GSE17721_2006_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 12 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4133
exact_source: GSE17721_2006_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 12 h versus those stimulated with CpG DNA (TLR9 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4135
exact_source: GSE17721_2007_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4136
exact_source: GSE17721_2007_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 12 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4139
exact_source: GSE17721_2008_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4140
exact_source: GSE17721_2008_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 4 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4141
exact_source: GSE17721_2009_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4142
exact_source: GSE17721_2009_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4143
exact_source: GSE17721_2010_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4145
exact_source: GSE17721_2010_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 0.5 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4146
exact_source: GSE17721_2011_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 4 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4147
exact_source: GSE17721_2011_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 4 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4148
exact_source: GSE17721_2012_200_UP
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 12 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4150
exact_source: GSE17721_2012_200_DN
source_species_code: MM
GEO_id: GSE17721
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with Gardiquimod (TLR7 agonist) at 12 h versus those stimulated with Gardiquimod (TLR7 agonist) at 24 h.

description_full:
[cell repeats an earlier one in this file: 115 characters]


systematic_name: M4152
exact_source: GSE17974_1179_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 0.5 h.

description_full:
  The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells.


systematic_name: M4154
exact_source: GSE17974_1179_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 0.5 h.

description_full:
  The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells.


systematic_name: M4156
exact_source: GSE17974_1180_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 1 h.

description_full:
  The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells.


systematic_name: M4157
exact_source: GSE17974_1180_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 1 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4158
exact_source: GSE17974_1181_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 2 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4159
exact_source: GSE17974_1181_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 2 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4160
exact_source: GSE17974_1182_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 4 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4161
exact_source: GSE17974_1182_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 4 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4164
exact_source: GSE17974_1183_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 6 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4166
exact_source: GSE17974_1183_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 6 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4167
exact_source: GSE17974_1184_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4168
exact_source: GSE17974_1184_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4169
exact_source: GSE17974_1185_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 24 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4173
exact_source: GSE17974_1185_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 24 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4174
exact_source: GSE17974_1186_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4176
exact_source: GSE17974_1186_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4177
exact_source: GSE17974_1187_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4178
exact_source: GSE17974_1187_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4179
exact_source: GSE17974_1188_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4180
exact_source: GSE17974_1188_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4181
exact_source: GSE17974_1189_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4182
exact_source: GSE17974_1189_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4185
exact_source: GSE17974_1190_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4186
exact_source: GSE17974_1190_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4187
exact_source: GSE17974_1191_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 4 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4188
exact_source: GSE17974_1191_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 4 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4189
exact_source: GSE17974_1192_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4190
exact_source: GSE17974_1192_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4192
exact_source: GSE17974_1193_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 12 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4194
exact_source: GSE17974_1193_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 12 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4195
exact_source: GSE17974_1194_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 24 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4197
exact_source: GSE17974_1194_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 24 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4199
exact_source: GSE17974_1195_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 48 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4200
exact_source: GSE17974_1195_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 48 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4201
exact_source: GSE17974_1196_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4202
exact_source: GSE17974_1196_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4206
exact_source: GSE17974_1197_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 0.5 h versus the untreated cells at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4207
exact_source: GSE17974_1197_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 0.5 h versus the untreated cells at 0.5 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4208
exact_source: GSE17974_1198_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h versus the untreated cells at 1 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4209
exact_source: GSE17974_1198_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h versus the untreated cells at 1 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4211
exact_source: GSE17974_1199_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h versus the untreated cells at 2 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4212
exact_source: GSE17974_1199_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h versus the untreated cells at 2 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4213
exact_source: GSE17974_1200_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 4 h versus the untreated cells at 4 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4214
exact_source: GSE17974_1200_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 4 h versus the untreated cells at 4 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4216
exact_source: GSE17974_1201_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h versus the untreated cells at 6 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4218
exact_source: GSE17974_1201_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h versus the untreated cells at 6 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4221
exact_source: GSE17974_1202_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 12 h versus the untreated cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4222
exact_source: GSE17974_1202_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 12 h versus the untreated cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4224
exact_source: GSE17974_1203_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 24 h versus the untreated cells at 24 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4227
exact_source: GSE17974_1203_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 24 h versus the untreated cells at 24 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4228
exact_source: GSE17974_1204_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 48 h versus the untreated cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4231
exact_source: GSE17974_1204_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 48 h versus the untreated cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4232
exact_source: GSE17974_1205_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4233
exact_source: GSE17974_1205_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 72 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4234
exact_source: GSE17974_1206_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0.5 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4236
exact_source: GSE17974_1206_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0.5 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4237
exact_source: GSE17974_1207_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 1 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4239
exact_source: GSE17974_1207_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 1 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4240
exact_source: GSE17974_1208_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 2 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4243
exact_source: GSE17974_1208_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 2 h versus the untreated cells at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4244
exact_source: GSE17974_1209_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 0.5 h versus those at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4245
exact_source: GSE17974_1209_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 0.5 h versus those at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4247
exact_source: GSE17974_1210_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 1.5 h versus those at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4248
exact_source: GSE17974_1210_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 1.5 h versus those at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4249
exact_source: GSE17974_1211_200_UP
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h versus those at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4250
exact_source: GSE17974_1211_200_DN
source_species_code: HS
GEO_id: GSE17974
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] T cells treated with IL4 [GeneID=3565] and anti-IL12 at 2 h versus those at 72 h.

description_full:
[cell repeats an earlier one in this file: 139 characters]


systematic_name: M4251
exact_source: GSE18148_1212_200_UP
source_species_code: MM
GEO_id: GSE18148
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regualted in comparison of regulatory T cell (Treg) from CBFB [GeneID=865] deficient mice versus those from wild type animals.

description_full:
  Gene expression profiles of Cbfb-deficient and control Treg cells were compared. Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with another transcription factor Runx1 (also known as AML1). Here we showed that Treg cell-specific deficiency of Cbfβ, a cofactor for all Runx proteins, or that of Runx1, but not Runx3, induced lymphoproliferation, autoimmune disease, and hyper-production of IgE. Cbfb-deleted Treg cells exhibited impaired suppressive function in vitro and in vivo, with altered gene expression profiles including attenuated expression of FoxP3 and high expression of interleukin-4. The Runx complex bound to more than 3000 gene loci in Treg cells, including the Foxp3 regulatory regions and the Il4 silencer. In addition, knockdown of RUNX1 showed that RUNX1 is required for the optimal regulation of FoxP3 expression in human T cells. Taken together, our results indicate that the Runx1-Cbfβ heterodimer is indispensable for in vivo Treg cell function, in particular, suppressive activity and optimal expression of FoxP3.


systematic_name: M4252
exact_source: GSE18148_1212_200_DN
source_species_code: MM
GEO_id: GSE18148
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regualted in comparison of regulatory T cell (Treg) from CBFB [GeneID=865] deficient mice versus those from wild type animals.

description_full:
  Gene expression profiles of Cbfb-deficient and control Treg cells were compared. Naturally arising regulatory T (Treg) cells express the transcription factor FoxP3, which critically controls the development and function of Treg cells. FoxP3 interacts with


systematic_name: M4255
exact_source: GSE18791_1538_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 1 h.

description_full:
  The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system requires knowledge of the underlying genetic regulatory network that operates during an uninhibited antiviral response. In order to isolate and identify this network, we studied DCs infected with Newcastle Disease Virus (NDV), which is able to stimulate innate immunity and DC maturation through activation of RIG-I signaling, but lacks the ability to evade the human interferon response. To analyze this experimental model, we developed a new approach integrating genome-wide expression kinetics and time-dependent promoter analysis. We found that the genetic program underlying the antiviral cell state transition during the first 18-hours post-infection could be explained by a single regulatory network. Gene expression changes were driven by a step-wise multi-factor cascading control mechanism, where the specific transcription factors controlling expression changed over time. Within this network, most individual genes are regulated by multiple factors, indicating robustness against virus-encoded immune evasion genes. In addition to effectively recapitulating current biological knowledge, we predicted, and validated experimentally, antiviral roles for several novel transcription factors. More generally, our results show how a genetic program can be temporally controlled through a single regulatory network to achieve the large-scale genetic reprogramming characteristic of cell state transitions.


systematic_name: M4256
exact_source: GSE18791_1538_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 1 h.

description_full:
  The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system requires knowledge of the underlying genetic regulatory network that operates during an uninhibited antiviral response. In order to isolate and identify this network, we studied DCs infected with Newcastle Disease Virus (NDV), which is able to stimulate innate immunity and DC maturation through activation of RIG-I signaling, but lacks the ability to evade the human interferon response. To analyze this experimental model, we developed a new approach integrating genome-wide expression kinetics and time-dependent promoter analysis. We found that the genetic program underlying the antiviral cell state transition during the first 18-hours post-infection could be explained by a single regulatory network. Gene expression changes were driven by a step-wise multi-factor cascading control mechanism, where the specific transcription factors controlling expression changed over time. Within this network, most individual genes are regulated by multiple factors, indicating robustness against virus-encoded immune evasion genes. In addition to effectively recapitulating current biological knowledge, we predicted, and validated experimentally, antiviral roles for several novel transcription factors. More generally, our results show how a genetic program can be temporally controlled through a single regulatory network to achieve the large-scale genetic reprogramming characteristic of cell state transitions.


systematic_name: M4257
exact_source: GSE18791_1539_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 2 h.

description_full:
  The dendritic cell (DC) is a master regulator of immune responses. Pathogenic viruses subvert normal immune function in DCs through the expression of immune antagonists. Understanding how these antagonists interact with the host immune system requires knowledge of the underlying genetic regulatory network that operates during an uninhibited antiviral response. In order to isolate and identify this network, we studied DCs infected with Newcastle Disease Virus (NDV), which is able to stimulate innate immunity and DC maturation through activation of RIG-I signaling, but lacks the ability to evade the human interferon response. To analyze this experimental model, we developed a new approach integrating genome-wide expression kinetics and time-dependent promoter analysis. We found that the genetic program underlying the antiviral cell state transition during the first 18-hours post-infection could be explained by a single regulatory network. Gene expression changes were driven by a step-wise multi-factor cascading control mechanism, where the specific transcription factors controlling expression changed over time. Within this network, most individual genes are regulated by multiple factors, indicating robustness against virus-encoded immune evasion genes. In addition to effectively recapitulating current biological knowledge, we predicted, and validated experimentally, antiviral roles for several novel transcription factors. More generally, our results show how a genetic program can be temporally controlled through a single regulatory network to achieve the large-scale genetic reprogramming characteristic of cell state transitions.


systematic_name: M4259
exact_source: GSE18791_1539_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 2 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4260
exact_source: GSE18791_1540_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 4 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4261
exact_source: GSE18791_1540_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 4 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4262
exact_source: GSE18791_1541_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4264
exact_source: GSE18791_1541_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4266
exact_source: GSE18791_1542_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 8 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4267
exact_source: GSE18791_1542_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 8 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4268
exact_source: GSE18791_1543_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 10 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4269
exact_source: GSE18791_1543_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 10 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4271
exact_source: GSE18791_1544_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 12 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4272
exact_source: GSE18791_1544_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 12 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4274
exact_source: GSE18791_1545_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 14 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4277
exact_source: GSE18791_1545_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 14 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4278
exact_source: GSE18791_1546_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 16 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4279
exact_source: GSE18791_1546_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 16 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4283
exact_source: GSE18791_1547_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4284
exact_source: GSE18791_1547_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4285
exact_source: GSE18791_1548_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 1 h versus cDCs infected with Newcastle disease virus (NDV) at 1 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4286
exact_source: GSE18791_1548_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 1 h versus cDCs infected with Newcastle disease virus (NDV) at 1 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4287
exact_source: GSE18791_1549_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 2 h versus cDCs infected with Newcastle disease virus (NDV) at 2 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4289
exact_source: GSE18791_1549_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 2 h versus cDCs infected with Newcastle disease virus (NDV) at 2 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4291
exact_source: GSE18791_1550_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 6 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4292
exact_source: GSE18791_1550_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 6 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4293
exact_source: GSE18791_1551_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 10 h versus cDCs infected with Newcastle disease virus (NDV) at 10 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4294
exact_source: GSE18791_1551_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 10 h versus cDCs infected with Newcastle disease virus (NDV) at 10 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4295
exact_source: GSE18791_1552_200_UP
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of control conventional dendritic cells (cDC) at 18 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4296
exact_source: GSE18791_1552_200_DN
source_species_code: HS
GEO_id: GSE18791
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 18 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h.

description_full:
[cell repeats an earlier one in this file: 1654 characters]


systematic_name: M4297
exact_source: GSE19825_1387_200_UP
source_species_code: MM
GEO_id: GSE19825
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] low T cells at.

description_full:
  CD25, the high affinity interleukin-2 (IL-2) receptor alpha-chain, is rapidly upregulated by antigen-specific CD8+ T cells after T cell receptor stimulation. We demonstrated that during an acute viral infection, CD25 expression was dynamic, and a subset of virus-specific CD8+ T cells sustained CD25 expression longer than the rest. Examination of the in vivo fate of effector CD8+ T cells exhibiting differential responsiveness to IL-2 revealed that CD25lo cells, which were relatively less sensitive to IL-2, preferentially upregulated CD127 and CD62L and gave rise to the functional long-lived memory pool. In contrast, CD25hi cells that accumulate enhanced IL-2 signals, proliferated more rapidly, were prone to apoptosis, exhibited a more pronounced effector phenotype, and appeared to be terminally differentiated. Sustained IL-2 receptor signaling resulted in increased CD8+ T cell proliferation, higher granzyme B expression and exaggerated contraction after antigen clearance. These data support the hypothesis that prolonged IL-2 signals during priming promote terminal effector differentiation of CD8+ T cells.


systematic_name: M4298
exact_source: GSE19825_1387_200_DN
source_species_code: MM
GEO_id: GSE19825
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] low T cells at.

description_full:
  CD25, the high affinity interleukin-2 (IL-2) receptor alpha-chain, is rapidly upregulated by antigen-specific CD8+ T cells after T cell receptor stimulation. We demonstrated that during an acute viral infection, CD25 expression was dynamic, and a subset of virus-specific CD8+ T cells sustained CD25 expression longer than the rest. Examination of the in vivo fate of effector CD8+ T cells exhibiting differential responsiveness to IL-2 revealed that CD25lo cells, which were relatively less sensitive to IL-2, preferentially upregulated CD127 and CD62L and gave rise to the functional long-lived memory pool. In contrast, CD25hi cells that accumulate enhanced IL-2 signals, proliferated more rapidly, were prone to apoptosis, exhibited a more pronounced effector phenotype, and appeared to be terminally differentiated. Sustained IL-2 receptor signaling resulted in increased CD8+ T cell proliferation, higher granzyme B expression and exaggerated contraction after antigen clearance. These data support the hypothesis that prolonged IL-2 signals during priming promote terminal effector differentiation of CD8+ T cells.


systematic_name: M4299
exact_source: GSE19825_1388_200_UP
source_species_code: MM
GEO_id: GSE19825
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] high T cells at.

description_full:
  CD25, the high affinity interleukin-2 (IL-2) receptor alpha-chain, is rapidly upregulated by antigen-specific CD8+ T cells after T cell receptor stimulation. We demonstrated that during an acute viral infection, CD25 expression was dynamic, and a subset of virus-specific CD8+ T cells sustained CD25 expression longer than the rest. Examination of the in vivo fate of effector CD8+ T cells exhibiting differential responsiveness to IL-2 revealed that CD25lo cells, which were relatively less sensitive to IL-2, preferentially upregulated CD127 and CD62L and gave rise to the functional long-lived memory pool. In contrast, CD25hi cells that accumulate enhanced IL-2 signals, proliferated more rapidly, were prone to apoptosis, exhibited a more pronounced effector phenotype, and appeared to be terminally differentiated. Sustained IL-2 receptor signaling resulted in increased CD8+ T cell proliferation, higher granzyme B expression and exaggerated contraction after antigen clearance. These data support the hypothesis that prolonged IL-2 signals during priming promote terminal effector differentiation of CD8+ T cells.


systematic_name: M4300
exact_source: GSE19825_1388_200_DN
source_species_code: MM
GEO_id: GSE19825
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD8 T cells versus effector CD8 IL2RA [GeneID=3559] high T cells at.

description_full:
[cell repeats an earlier one in this file: 1121 characters]


systematic_name: M4301
exact_source: GSE19825_1389_200_UP
source_species_code: MM
GEO_id: GSE19825
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of effector CD8 IL2RA [GeneID=3559] low T cells versus effector CD8 IL2RA [GeneID=3559] high cells.

description_full:
[cell repeats an earlier one in this file: 1121 characters]


systematic_name: M4302
exact_source: GSE19825_1389_200_DN
source_species_code: MM
GEO_id: GSE19825
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of effector CD8 IL2RA [GeneID=3559] low T cells versus effector CD8 IL2RA [GeneID=3559] high cells.

description_full:
[cell repeats an earlier one in this file: 1121 characters]


systematic_name: M4309
exact_source: GSE20151_2128_200_UP
source_species_code: HS
GEO_id: GSE20151
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of contols neutrophils versus those infected with a bacterium (F. nucleatum).

description_full:
  Neutrophils are known to be stimulated by different periodontal bacteria to produce reactive oxygen species and cytokines. It is inportant to investigate the gene changes made by bacteria of importance, of which, for periodontal disease, fusobaterium nucleatum is one. we used microarrays to investigate gene experssion changes in peripheral blood neutrophils werwhich e stimulated with or with out Fusobacterium Nucleatum (10953).


systematic_name: M4310
exact_source: GSE20151_2128_200_DN
source_species_code: HS
GEO_id: GSE20151
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of contols neutrophils versus those infected with a bacterium (F. nucleatum).

description_full:
  Neutrophils are known to be stimulated by different periodontal bacteria to produce reactive oxygen species and cytokines. It is inportant to investigate the gene changes made by bacteria of importance, of which, for periodontal disease, fusobaterium nucleatum is one. we used microarrays to investigate gene experssion changes in peripheral blood neutrophils werwhich e stimulated with or with out Fusobacterium Nucleatum (10953).


systematic_name: M4311
exact_source: GSE20366_1426_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TregCD103-Klrg1 versus TconvLP (see Table 1S in the paper for details).

description_full:
  Regulatory T (Treg) cells that express the FoxP3 transcription factor are essential for lymphoid homeostasis and immune tolerance to self. Other non-immunological functions of Treg cells, such as controlling metabolic function in adipose tissue, are also emerging. Treg cells originate primarily in the thymus, but can also be elicited from conventional T cells by in vivo exposure to low-dose antigen or homeostatic expansion, or by activation in the presence of TGFβ in vitro. Treg cells are characterized by a distinct transcriptional signature controlled in part, but not solely, by FoxP3. For a better perspective on transcriptional control in Treg cells, we compared gene expression profiles of a broad panel of Treg cells from various origins or anatomical locations. Treg cells generated by different means form different sub-phenotypes identifiable by particular combinations of transcripts, none of which fully encompass the entire Treg signature. Molecules involved in Treg effector function, chemokine receptors, and the transcription factors that control them are differentially represented in these subphenotypes. Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFβ, but instead they resembled a CD103+Klrg1+ subphenotype preferentially generated in response to lymphopenia.


systematic_name: M4312
exact_source: GSE20366_1426_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregCD103-Klrg1 versus TconvLP (see Table 1S in the paper for details).

description_full:
  Regulatory T (Treg) cells that express the FoxP3 transcription factor are essential for lymphoid homeostasis and immune tolerance to self. Other non-immunological functions of Treg cells, such as controlling metabolic function in adipose tissue, are also emerging. Treg cells originate primarily in the thymus, but can also be elicited from conventional T cells by in vivo exposure to low-dose antigen or homeostatic expansion, or by activation in the presence of TGFβ in vitro. Treg cells are characterized by a distinct transcriptional signature controlled in part, but not solely, by FoxP3. For a better perspective on transcriptional control in Treg cells, we compared gene expression profiles of a broad panel of Treg cells from various origins or anatomical locations. Treg cells generated by different means form different sub-phenotypes identifiable by particular combinations of transcripts, none of which fully encompass the entire Treg signature. Molecules involved in Treg effector function, chemokine receptors, and the transcription factors that control them are differentially represented in these subphenotypes. Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFβ, but instead they resembled a CD103+Klrg1+ subphenotype preferentially generated in response to lymphopenia.


systematic_name: M4313
exact_source: GSE20366_1427_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TregLP versus Homeo Convert (see Table 1S in the paper for details).

description_full:
  Regulatory T (Treg) cells that express the FoxP3 transcription factor are essential for lymphoid homeostasis and immune tolerance to self. Other non-immunological functions of Treg cells, such as controlling metabolic function in adipose tissue, are also emerging. Treg cells originate primarily in the thymus, but can also be elicited from conventional T cells by in vivo exposure to low-dose antigen or homeostatic expansion, or by activation in the presence of TGFβ in vitro. Treg cells are characterized by a distinct transcriptional signature controlled in part, but not solely, by FoxP3. For a better perspective on transcriptional control in Treg cells, we compared gene expression profiles of a broad panel of Treg cells from various origins or anatomical locations. Treg cells generated by different means form different sub-phenotypes identifiable by particular combinations of transcripts, none of which fully encompass the entire Treg signature. Molecules involved in Treg effector function, chemokine receptors, and the transcription factors that control them are differentially represented in these subphenotypes. Treg cells from the gut proved dissimilar to cells elicited by exposure to TGFβ, but instead they resembled a CD103+Klrg1+ subphenotype preferentially generated in response to lymphopenia.


systematic_name: M4314
exact_source: GSE20366_1427_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregLP versus Homeo Convert (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4316
exact_source: GSE20366_1428_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TregLP versus DEC-Pept Convert (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4318
exact_source: GSE20366_1428_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregLP versus DEC-Pept Convert (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4323
exact_source: GSE20366_1429_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TconvLP versus Homeo Foxp3- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4326
exact_source: GSE20366_1429_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TconvLP versus Homeo Foxp3- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4327
exact_source: GSE20366_1430_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TconvLP versus DEC-Pept CD25- (see Table S1 in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4328
exact_source: GSE20366_1430_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TconvLP versus DEC-Pept CD25- (see Table S1 in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4330
exact_source: GSE20366_1431_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of Homeo Convert versus Homeo Foxp3- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4331
exact_source: GSE20366_1431_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of Homeo Convert versus Homeo Foxp3- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4332
exact_source: GSE20366_1432_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of DEC-Pept Convert versus DEC-Pept CD25- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4334
exact_source: GSE20366_1432_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of DEC-Pept Convert versus DEC-Pept CD25- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4335
exact_source: GSE20366_1433_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TregCD103-Klrg1- versus TregCD103+Klrg1- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4338
exact_source: GSE20366_1433_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregCD103-Klrg1- versus TregCD103+Klrg1- (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4341
exact_source: GSE20366_1434_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TregCD103-Klrg1- versus TregCD103+Klrg1+ (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4343
exact_source: GSE20366_1434_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregCD103-Klrg1- versus TregCD103+Klrg1+ (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4344
exact_source: GSE20366_1435_200_UP
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of TregCD103+Klrg1- versus TregCD103+Klrg1+ (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4346
exact_source: GSE20366_1435_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregCD103+Klrg1- versus TregCD103+Klrg1+ (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4348
exact_source: GSE20366_1436_200_DN
source_species_code: MM
GEO_id: GSE20366
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of TregLP versus TconvLP (see Table 1S in the paper for details).

description_full:
[cell repeats an earlier one in this file: 1316 characters]


systematic_name: M4349
exact_source: GSE20715_2072_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice versus that from TLR4 [GeneID=7099] deficient animals.

description_full:
  We previously identified toll-like receptor 4 (Tlr4) as a candidate gene responsible for ozone (O3)-induced pulmonary hyperpermeability and inflammation. The objective of this study was to determine the mechanism through which TLR4 modulates O3-induced pulmonary responses and to utilize transcriptomics to determine TLR4 effector molecules. C3H/HeJ (HeJ; Tlr4 mutant) and C3H/HeOuJ (OuJ; Tlr4 normal), mice were exposed continuously to 0.3 ppm O3 or filtered air for 6, 24, 48 or 72 hr. Affymetrix Mouse430A_MOE gene arrays were used to analyze lung homogenates from HeJ and OuJ mice followed using a bioinformatic analysis. Inflammation was assessed by bronchoalveolar lavage and molecular analysis by ELISA, immunoblotting, and transcription factor activity. TLR4 signals through both the MYD88-dependent and independent pathways in OuJ mice, which involves MAP kinase activation, NF-kappaB, AP-1, and KC. Microarray analyses identifiedTLR4 responsive genes for strain and time in OuJ versus HeJ mice (p&lt;0.05). One significantly upregulated cluster of genes in OuJ were the heat shock proteins (Hspa1b; Hsp70), Hsp90ab1). Furthermore, O3-induced expression of HSP70 protein was increased in OuJ compared to HeJ mice following 24-48 h O3. Moreover, BAL polymorphonuclear leukocytes (PMN) and total protein were significantly reduced in response to O3 in Hspa1a/Hspa1btm1Dix (Hsp70-/-) compared to Hsp70+/+ mice (p&lt;0.05). TLR4 signaling (MYD88-dependent), ERK1/2, AP-1 activity, and KC protein content were also significantly reduced after O3 exposure in Hsp70-/- compared to Hsp70+/+ mice (p&lt;0.05). These studies suggest that HSP70 is involved in the regulation of O3-induced lung inflammation through the TLR4 pathway and provide evidence that HSP70 is an endogenous in vivo TLR4 ligand.


systematic_name: M4350
exact_source: GSE20715_2072_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice versus that from TLR4 [GeneID=7099] deficient animals.

description_full:
  We previously identified toll-like receptor 4 (Tlr4) as a candidate gene responsible for ozone (O3)-induced pulmonary hyperpermeability and inflammation. The objective of this study was to determine the mechanism through which TLR4 modulates O3-induced pulmonary responses and to utilize transcriptomics to determine TLR4 effector molecules. C3H/HeJ (HeJ; Tlr4 mutant) and C3H/HeOuJ (OuJ; Tlr4 normal), mice were exposed continuously to 0.3 ppm O3 or filtered air for 6, 24, 48 or 72 hr. Affymetrix Mouse430A_MOE gene arrays were used to analyze lung homogenates from HeJ and OuJ mice followed using a bioinformatic analysis. Inflammation was assessed by bronchoalveolar lavage and molecular analysis by ELISA, immunoblotting, and transcription factor activity. TLR4 signals through both the MYD88-dependent and independent pathways in OuJ mice, which involves MAP kinase activation, NF-kappaB, AP-1, and KC. Microarray analyses identifiedTLR4 responsive genes for strain and time in OuJ versus HeJ mice (p&lt;0.05). One significantly upregulated cluster of genes in OuJ were the heat shock proteins (Hspa1b; Hsp70), Hsp90ab1). Furthermore, O3-induced expression of HSP70 protein was increased in OuJ compared to HeJ mice following 24-48 h O3. Moreover, BAL polymorphonuclear leukocytes (PMN) and total protein were significantly reduced in response to O3 in Hspa1a/Hspa1btm1Dix (Hsp70-/-) compared to Hsp70+/+ mice (p&lt;0.05). TLR4 signaling (MYD88-dependent), ERK1/2, AP-1 activity, and KC protein content were also significantly reduced after O3 exposure in Hsp70-/- compared to Hsp70+/+ mice (p&lt;0.05). These studies suggest that HSP70 is involved in the regulation of O3-induced lung inflammation through the TLR4 pathway and provide evidence that HSP70 is an endogenous in vivo TLR4 ligand.


systematic_name: M4351
exact_source: GSE20715_2073_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparson of lung tissue from wild type mice subjected to ozone for 6 h vs that from TLR4 [GeneID=7099] deficient animal subjected to ozone for 6 h.

description_full:
  We previously identified toll-like receptor 4 (Tlr4) as a candidate gene responsible for ozone (O3)-induced pulmonary hyperpermeability and inflammation. The objective of this study was to determine the mechanism through which TLR4 modulates O3-induced pulmonary responses and to utilize transcriptomics to determine TLR4 effector molecules. C3H/HeJ (HeJ; Tlr4 mutant) and C3H/HeOuJ (OuJ; Tlr4 normal), mice were exposed continuously to 0.3 ppm O3 or filtered air for 6, 24, 48 or 72 hr. Affymetrix Mouse430A_MOE gene arrays were used to analyze lung homogenates from HeJ and OuJ mice followed using a bioinformatic analysis. Inflammation was assessed by bronchoalveolar lavage and molecular analysis by ELISA, immunoblotting, and transcription factor activity. TLR4 signals through both the MYD88-dependent and independent pathways in OuJ mice, which involves MAP kinase activation, NF-kappaB, AP-1, and KC. Microarray analyses identifiedTLR4 responsive genes for strain and time in OuJ versus HeJ mice (p&lt;0.05). One significantly upregulated cluster of genes in OuJ were the heat shock proteins (Hspa1b; Hsp70), Hsp90ab1). Furthermore, O3-induced expression of HSP70 protein was increased in OuJ compared to HeJ mice following 24-48 h O3. Moreover, BAL polymorphonuclear leukocytes (PMN) and total protein were significantly reduced in response to O3 in Hspa1a/Hspa1btm1Dix (Hsp70-/-) compared to Hsp70+/+ mice (p&lt;0.05). TLR4 signaling (MYD88-dependent), ERK1/2, AP-1 activity, and KC protein content were also significantly reduced after O3 exposure in Hsp70-/- compared to Hsp70+/+ mice (p&lt;0.05). These studies suggest that HSP70 is involved in the regulation of O3-induced lung inflammation through the TLR4 pathway and provide evidence that HSP70 is an endogenous in vivo TLR4 ligand.


systematic_name: M4352
exact_source: GSE20715_2073_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparson of lung tissue from wild type mice subjected to ozone for 6 h vs that from TLR4 [GeneID=7099] deficient animal subjected to ozone for 6 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4353
exact_source: GSE20715_2074_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 24 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 24 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4354
exact_source: GSE20715_2074_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 24 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 24 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4355
exact_source: GSE20715_2075_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 48 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4358
exact_source: GSE20715_2075_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 48 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4360
exact_source: GSE20715_2076_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 6 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4365
exact_source: GSE20715_2076_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 6 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4366
exact_source: GSE20715_2077_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 24 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4367
exact_source: GSE20715_2077_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 24 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4368
exact_source: GSE20715_2078_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 48 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4369
exact_source: GSE20715_2078_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from wild type mice subjected to ozone for 48 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4370
exact_source: GSE20715_2079_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 6 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4373
exact_source: GSE20715_2079_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 6 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4374
exact_source: GSE20715_2080_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 24 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4375
exact_source: GSE20715_2080_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 24 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4379
exact_source: GSE20715_2081_200_UP
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4386
exact_source: GSE20715_2081_200_DN
source_species_code: MM
GEO_id: GSE20715
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 48 h.

description_full:
[cell repeats an earlier one in this file: 1799 characters]


systematic_name: M4387
exact_source: GSE2197_1052_200_UP
source_species_code: MM
GEO_id: GSE2197
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) treated with immunosuppressive DNA versus the untreated cells.

description_full:
  Bone marrow-derived dendritic cells were left untreated or stimulated with lipid-transfected double-stranded DNA or CpG oligonucleotides for four hours before harvesting.


systematic_name: M4390
exact_source: GSE2197_1052_200_DN
source_species_code: MM
GEO_id: GSE2197
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) treated with immunosuppressive DNA versus the untreated cells.

description_full:
  Bone marrow-derived dendritic cells were left untreated or stimulated with lipid-transfected double-stranded DNA or CpG oligonucleotides for four hours before harvesting.


systematic_name: M4393
exact_source: GSE2197_1051_200_UP
source_species_code: MM
GEO_id: GSE2197
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) treated with CpG DNA (TLR9 agonist) DNA versus the untreated cells.

description_full:
  Bone marrow-derived dendritic cells were left untreated or stimulated with lipid-transfected double-stranded DNA or CpG oligonucleotides for four hours before harvesting.


systematic_name: M4398
exact_source: GSE2197_1051_200_DN
source_species_code: MM
GEO_id: GSE2197
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) treated with CpG DNA (TLR9 agonist) DNA versus the untreated cells.

description_full:
[cell repeats an earlier one in this file: 170 characters]


description_brief: Genes up-regulated in comparison of regulatory T cell (Treg) versus conventional T cells.
systematic_name: M4400
exact_source: GSE22045_1301_200_UP
source_species_code: HS
GEO_id: GSE22045
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Human regulatory T cells (TR) cells have potential for the treatment of immune mediated diseases, such as graft versus host disease, but the anergic phenotype of these cells makes them difficult to expand in vitro. We have examined the requirements for growth and cytokine expression from highly purified human TR cells, and correlated these findings with the signal transduction events of these cells. We demonstrate that these cells do not proliferate or secrete IL-10 even in the presence of high doses of IL-2. Stimulation with a superagonistic anti-CD28 antibody (clone 9D4) and IL-2 partially reversed the proliferative defect, and this correlated with reversal of the defective calcium mobilization in these cells. Dendritic cells were effective at promoting TR cell proliferation, and under these conditions the proliferative capacity of TR cells was comparable to conventional CD4 lymphocytes. Blocking TGF-beta activity abrogated IL-10 expression from these cells, while addition of TGF-beta resulted in IL-10 production. These data demonstrate the ability of dendritic cells to provide proper costimulation to overcome the anergic phenotype of TR cells. In addition, these data demonstrate for the first time that TGF-beta is critical to enable TR cells to express IL-10.


description_brief: Genes up-regulated in comparison of naive CD8 T cells versus naive CD4 [GeneID=920] T cells.
systematic_name: M4402
exact_source: GSE22886_1626_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. In order to identify such patterns, we set out to broadly profile gene expression in a variety of immune cells.


systematic_name: M4408
exact_source: GSE22886_1628_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated memory CD4 [GeneID=920] CD8 T cells versus stimulated CD4 [GeneID=920] CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4410
exact_source: GSE22886_1628_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated memory CD4 [GeneID=920] CD8 T cells versus stimulated CD4 [GeneID=920] CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4411
exact_source: GSE22886_1629_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulated memory CD4 [GeneID=920] CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4412
exact_source: GSE22886_1629_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulated memory CD4 [GeneID=920] CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4413
exact_source: GSE22886_1630_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated NK cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4415
exact_source: GSE22886_1630_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated NK cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4416
exact_source: GSE22886_1631_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated memory CD4 [GeneID=920] CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4417
exact_source: GSE22886_1631_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated memory CD4 [GeneID=920] CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4443
exact_source: GSE22886_1641_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive B cells  versus plasma cells from bone marrow and blood.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4449
exact_source: GSE22886_1643_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of memory IgG IgA B cells versus plasma cells from bone marrow and blood.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4450
exact_source: GSE22886_1643_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of memory IgG IgA B cells versus plasma cells from bone marrow and blood.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4456
exact_source: GSE22886_1645_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of memory IgM B cells versus plasma cells from bone marrow and blood.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4457
exact_source: GSE22886_1645_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of memory IgM B cells versus plasma cells from bone marrow and blood.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4459
exact_source: GSE22886_1646_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes cultured for 0 days versus those cultured for 1 day.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4461
exact_source: GSE22886_1647_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes cultured for 0 days versus those cultured for 7 days.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4463
exact_source: GSE22886_1648_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes cultured for 1 day versus those cultured for 7 days.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4473
exact_source: GSE22886_1652_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4474
exact_source: GSE22886_1652_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated neutrophils.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4475
exact_source: GSE22886_1653_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC).

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4476
exact_source: GSE22886_1653_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus unstimulated dendritic cells (DC).

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4478
exact_source: GSE22886_1654_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus monocytes cultured for 0 days.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4480
exact_source: GSE22886_1654_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus monocytes cultured for 0 days.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4498
exact_source: GSE22886_1661_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulated neutrophils.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4501
exact_source: GSE22886_1662_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulatd dendritic cells (DC).

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4503
exact_source: GSE22886_1662_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulatd dendritic cells (DC).

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4507
exact_source: GSE22886_1664_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 12 h versus stimulated CD4 [GeneID=920] Th2 cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4509
exact_source: GSE22886_1664_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 12 h versus stimulated CD4 [GeneID=920] Th2 cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4510
exact_source: GSE22886_1665_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 48 h versus stimulated CD4 [GeneID=920] Th2 cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4512
exact_source: GSE22886_1665_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 48 h versus stimulated CD4 [GeneID=920] Th2 cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4514
exact_source: GSE22886_1666_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of NK cells stimulated with IL2 [GeneID=3558] at 16 h versus NK cells stimulated with IL15 [GeneID=3600] at 16 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4516
exact_source: GSE22886_1666_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of NK cells stimulated with IL2 [GeneID=3558] at 16 h versus NK cells stimulated with IL15 [GeneID=3600] at 16 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4518
exact_source: GSE22886_1667_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) versus 1 day DC stimulated with LPS (TLR4 agonist).

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4520
exact_source: GSE22886_1667_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) versus 1 day DC stimulated with LPS (TLR4 agonist).

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4521
exact_source: GSE22886_1668_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4523
exact_source: GSE22886_1668_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4524
exact_source: GSE22886_1669_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4525
exact_source: GSE22886_1669_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th1 cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4526
exact_source: GSE22886_1670_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4527
exact_source: GSE22886_1670_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 12 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4528
exact_source: GSE22886_1671_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4529
exact_source: GSE22886_1671_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 48 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4530
exact_source: GSE22886_1672_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3558] at 16 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4531
exact_source: GSE22886_1672_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL2 [GeneID=3558] at 16 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4532
exact_source: GSE22886_1673_200_UP
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated NK cells versus those stimulated with IL15 [GeneID=3600] at 16 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4533
exact_source: GSE22886_1673_200_DN
source_species_code: HS
GEO_id: GSE22886
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated NK cells versus those stimulated with IL15 [GeneID=3600] at 16 h.

description_full:
[cell repeats an earlier one in this file: 220 characters]


systematic_name: M4534
exact_source: GSE24026_1553_200_UP
source_species_code: HS
GEO_id: GSE24026
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of Jurkat T cells stimulated in the presence of PD-1 versus controls.

description_full:
  CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1). PD-1 inhibition contributes to impaired virus-specific T cell function in chronic infection because antibody-mediated blockade of its ligand, Programmed Death Ligand 1 (PD-L1) is sufficient to improve T cell function and reduce viral replication in animal models. Reversing PD-1 inhibition is therefore an attractive therapeutic target, but the cellular mechanisms by which PD-1 ligation results in T cell inhibition are not fully understood. PD-1 is thought to limit T cell activation by attenuating T cell receptor (TCR) signaling. It is not known whether PD-1 ligation also acts by upregulating genes in exhausted T cells that impair their function. Here, we analyzed gene-expression profiles from HIV-specific CD8+ T cells in patients with HIV and show that PD-1 coordinately upregulates a program of genes in exhausted CD8+ T cells from humans and mice. This program includes upregulation of basic leucine transcription factor, ATF-like (BATF), a transcription factor in the AP-1 family. Enforced expression of BATF was sufficient to impair T cell proliferation and cytokine secretion, while BATF knockdown reduced PD-1 inhibition. Silencing BATF in CD4+ and CD8+ T cells from chronic viremic patients rescued HIV-specific T cell function. Thus inhibitory receptors can cause T cell exhaustion by upregulating genes – such as BATF – that inhibit T cell function.


systematic_name: M4538
exact_source: GSE24026_1553_200_DN
source_species_code: HS
GEO_id: GSE24026
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of Jurkat T cells stimulated in the presence of PD-1 versus controls.

description_full:
  CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1). PD-1 inhibition contributes to impaired virus-specific T cell function in chronic infection because antibody-mediated blockade of its ligand, Programmed Death Ligand 1 (PD-L1) is sufficient to improve T cell function and reduce viral replication in animal models. Reversing PD-1 inhibition is therefore an attractive therapeutic target, but the cellular mechanisms by which PD-1 ligation results in T cell inhibition are not fully understood. PD-1 is thought to limit T cell activation by attenuating T cell receptor (TCR) signaling. It is not known whether PD-1 ligation also acts by upregulating genes in exhausted T cells that impair their function. Here, we analyzed gene-expression profiles from HIV-specific CD8+ T cells in patients with HIV and show that PD-1 coordinately upregulates a program of genes in exhausted CD8+ T cells from humans and mice. This program includes upregulation of basic leucine transcription factor, ATF-like (BATF), a transcription factor in the AP-1 family. Enforced expression of BATF was sufficient to impair T cell proliferation and cytokine secretion, while BATF knockdown reduced PD-1 inhibition. Silencing BATF in CD4+ and CD8+ T cells from chronic viremic patients rescued HIV-specific T cell function. Thus inhibitory receptors can cause T cell exhaustion by upregulating genes – such as BATF – that inhibit T cell function.


systematic_name: M4539
exact_source: GSE24081_1554_200_UP
source_species_code: HS
GEO_id: GSE24081
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD8 T cells with progressing HIV infection versus those with controlled HIV infection.

description_full:
  CD8+ T cells in chronic viral infections like HIV develop functional defects such as loss of IL-2 secretion and decreased proliferative potential that are collectively termed exhaustion1. Exhausted T cells express increased levels of multiple inhibitory receptors, such as Programmed Death 1 (PD-1). PD-1 inhibition contributes to impaired virus-specific T cell function in chronic infection because antibody-mediated blockade of its ligand, Programmed Death Ligand 1 (PD-L1) is sufficient to improve T cell function and reduce viral replication in animal models. Reversing PD-1 inhibition is therefore an attractive therapeutic target, but the cellular mechanisms by which PD-1 ligation results in T cell inhibition are not fully understood. PD-1 is thought to limit T cell activation by attenuating T cell receptor (TCR) signaling. It is not known whether PD-1 ligation also acts by upregulating genes in exhausted T cells that impair their function. Here, we analyzed gene-expression profiles from HIV-specific CD8+ T cells in patients with HIV and show that PD-1 coordinately upregulates a program of genes in exhausted CD8+ T cells from humans and mice. This program includes upregulation of basic leucine transcription factor, ATF-like (BATF), a transcription factor in the AP-1 family. Enforced expression of BATF was sufficient to impair T cell proliferation and cytokine secretion, while BATF knockdown reduced PD-1 inhibition. Silencing BATF in CD4+ and CD8+ T cells from chronic viremic patients rescued HIV-specific T cell function. Thus inhibitory receptors can cause T cell exhaustion by upregulating genes – such as BATF – that inhibit T cell function.


systematic_name: M4540
exact_source: GSE24081_1554_200_DN
source_species_code: HS
GEO_id: GSE24081
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD8 T cells with progressing HIV infection versus those with controlled HIV infection.

description_full:
[cell repeats an earlier one in this file: 1667 characters]


systematic_name: M4541
exact_source: GSE24102_2127_200_UP
source_species_code: MM
GEO_id: GSE24102
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of granulocytic myeloid derived suppressor cells (MDSC) versus neutrophils.

description_full:
  Myeloid derived suppressor cells (MDSC) playing the immune suppressive roles in tumor bearing host consists of two major subsets of granulocytic and monocytic cells. Granulocytic MDSC (G-MDSC) express CD11b+ Gr-1high Ly6G+ Ly6Clow and produce high level of reactive oxygen species (ROS). Interestingly, neutrophils are well known ROS producing cells during immune defensive process and share same surface markers with G-MDSC. These similar features always brought the fundamental questions what’s the difference between G-MDSC and neutrophils but it’s not yet proven clearly. In this study, we examined the gene expression of G-MDSC and neutrophils using Affymetrix microarray.


systematic_name: M4542
exact_source: GSE24102_2127_200_DN
source_species_code: MM
GEO_id: GSE24102
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of granulocytic myeloid derived suppressor cells (MDSC) versus neutrophils.

description_full:
  Myeloid derived suppressor cells (MDSC) playing the immune suppressive roles in tumor bearing host consists of two major subsets of granulocytic and monocytic cells. Granulocytic MDSC (G-MDSC) express CD11b+ Gr-1high Ly6G+ Ly6Clow and produce high level of reactive oxygen species (ROS). Interestingly, neutrophils are well known ROS producing cells during immune defensive process and share same surface markers with G-MDSC. These similar features always brought the fundamental questions what’s the difference between G-MDSC and neutrophils but it’s not yet proven clearly. In this study, we examined the gene expression of G-MDSC and neutrophils using Affymetrix microarray.


description_brief: Genes up-regulated in comparison of thymic progenitors versus DN2 thymocytes.
systematic_name: M4545
exact_source: GSE24142_2148_200_UP
source_species_code: MM
GEO_id: GSE24142
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Development of T-cells provides a unique opportunity to study cell-fate determination due to the accessability and the well defined stages of developmental stages. In order to understand the genetic programs underlying fetal and adult T‑cell fate specification we subjected highly purified fetal and adult T-cell progenitor populations to a genome‑wide transcriptional analysis. The aim was to identify molecular elements that govern T-cell fate specification as a whole but ultimately to isolate elements that were specific for a given population in a specific developmental window.


systematic_name: M4586
exact_source: GSE24634_1437_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3.

description_full:
  CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). The mechanisms that regulate the generation of peripheral iTregs are largely unknown. We used microarrays to gain insights into the molecular program of extrathymic Treg development.


systematic_name: M4587
exact_source: GSE24634_1437_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3.

description_full:
  CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). The mechanisms that regulate the generation of peripheral iTregs are largely unknown. We used microarrays to gain insights into the molecular program of extrathymic Treg development.


systematic_name: M4588
exact_source: GSE24634_1438_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 5.

description_full:
  CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). The mechanisms that regulate the generation of peripheral iTregs are largely unknown. We used microarrays to gain insights into the molecular program of extrathymic Treg development.


systematic_name: M4589
exact_source: GSE24634_1438_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4590
exact_source: GSE24634_1439_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4593
exact_source: GSE24634_1439_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4596
exact_source: GSE24634_1440_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 10.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4597
exact_source: GSE24634_1440_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 10.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4599
exact_source: GSE24634_1445_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3 versus CD25- T cells incubated with IL4 [GeneID=3565] at day 3.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4600
exact_source: GSE24634_1445_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3 versus CD25- T cells incubated with IL4 [GeneID=3565] at day 3.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4601
exact_source: GSE24634_1446_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25+ T cells treated with IL4 [GeneID=3565] versus CD25- T cells treated with IL4 [GeneID=3565] at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4603
exact_source: GSE24634_1446_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25+ T cells treated with IL4 [GeneID=3565] versus CD25- T cells treated with IL4 [GeneID=3565] at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4604
exact_source: GSE24634_1447_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4606
exact_source: GSE24634_1447_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4607
exact_source: GSE24634_1448_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 10 versus CD25- T cells treated with IL4 [GeneID=3565] at 10 h.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4612
exact_source: GSE24634_1448_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 10 versus CD25- T cells treated with IL4 [GeneID=3565] at 10 h.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4613
exact_source: GSE24634_1449_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25+ T effector cells treated with IL4 [GeneID=3565] at day 3 versus untreated CD25- T cells at day 3.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4616
exact_source: GSE24634_1449_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25+ T effector cells treated with IL4 [GeneID=3565] at day 3 versus untreated CD25- T cells at day 3.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4617
exact_source: GSE24634_1450_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD25+ T effector cells at day 5 versus untreated CD25- T cells at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4620
exact_source: GSE24634_1450_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD25+ T effector cells at day 5 versus untreated CD25- T cells at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4622
exact_source: GSE24634_1451_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD25+ T effector cells at day 7 versus untreated CD25- T cells at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4624
exact_source: GSE24634_1451_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD25+ T effector cells at day 7 versus untreated CD25- T cells at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4626
exact_source: GSE24634_1452_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD25+ T effector cells at day 10 versus untreated CD25- T cells at day 10.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4628
exact_source: GSE24634_1452_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD25+ T effector cells at day 10 versus untreated CD25- T cells at day 10.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4630
exact_source: GSE24634_1453_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 3 versus untreated CD25- T cells at day 3.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4632
exact_source: GSE24634_1453_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 3 versus untreated CD25- T cells at day 3.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4633
exact_source: GSE24634_1454_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 5 versus untreated CD25- T cells at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4635
exact_source: GSE24634_1454_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 5 versus untreated CD25- T cells at day 5.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4636
exact_source: GSE24634_1455_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 7 versus untreated CD25- T cells at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4638
exact_source: GSE24634_1455_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 7 versus untreated CD25- T cells at day 7.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4639
exact_source: GSE24634_1456_200_UP
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 10 versus untreated CD25- T cells at day 10.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4640
exact_source: GSE24634_1456_200_DN
source_species_code: HS
GEO_id: GSE24634
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 10 versus untreated CD25- T cells at day 10.

description_full:
[cell repeats an earlier one in this file: 359 characters]


systematic_name: M4641
exact_source: GSE25087_1323_200_UP
source_species_code: HS
GEO_id: GSE25087
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of fetal regulatory T cell (Treg) versus adult regulatory T cell (Treg).

description_full:
  We compared differences in fetal and adult T cells by performing whole genome profiling on sort-purified T cells (naïve CD4+ and Treg cells) from human fetal specimens (18-22 gestational weeks) and adult specimens (age 25-40 years old). Fetal and Adult Naïve CD4+ T cells phenotype: CD3+CD4+CD45RA+CCR7+CD27+, Fetal and Adult CD4+CD25+ Treg phenotype: CD3+CD4+CD25bright


systematic_name: M4643
exact_source: GSE25087_1323_200_DN
source_species_code: HS
GEO_id: GSE25087
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of fetal regulatory T cell (Treg) versus adult regulatory T cell (Treg).

description_full:
  We compared differences in fetal and adult T cells by performing whole genome profiling on sort-purified T cells (naïve CD4+ and Treg cells) from human fetal specimens (18-22 gestational weeks) and adult specimens (age 25-40 years old). Fetal and Adult Naïve CD4+ T cells phenotype: CD3+CD4+CD45RA+CCR7+CD27+, Fetal and Adult CD4+CD25+ Treg phenotype: CD3+CD4+CD25bright


systematic_name: M4647
exact_source: GSE25087_1325_200_UP
source_species_code: HS
GEO_id: GSE25087
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of fetal regulatory T cell (Treg) versus fetal conventional T cells.

description_full:
[cell repeats an earlier one in this file: 370 characters]


systematic_name: M4649
exact_source: GSE25087_1325_200_DN
source_species_code: HS
GEO_id: GSE25087
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of fetal regulatory T cell (Treg) versus fetal conventional T cells.

description_full:
[cell repeats an earlier one in this file: 370 characters]


systematic_name: M4650
exact_source: GSE25087_1326_200_UP
source_species_code: HS
GEO_id: GSE25087
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of adult regulatory T cell (Treg) versus adult conventional T cells.

description_full:
[cell repeats an earlier one in this file: 370 characters]


systematic_name: M4652
exact_source: GSE25087_1326_200_DN
source_species_code: HS
GEO_id: GSE25087
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of adult regulatory T cell (Treg) versus adult conventional T cells.

description_full:
[cell repeats an earlier one in this file: 370 characters]


description_brief: Genes up-regulated in comparison of naive CD8 T cells versus PD-1 high CD8 T cells.
systematic_name: M4654
exact_source: GSE26495_1502_200_UP
source_species_code: HS
GEO_id: GSE26495
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that PD-1 regulates T cell dysfunction during chronic LCMV infection in mice and PD-1 high cells exhibit an intense exhausted gene signature. These findings were extended to human chronic infections such as HIV, HCV and HBV. However, it is not known if PD-1 high cells of healthy humans have the traits of exhausted cells. In this study, we provide a comprehensive description of phenotype, function and gene expression profiles of PD-1 high versus PD-1 low CD8 T cells in the peripheral blood of healthy human adults as following: 1) The percentage of naive and memory CD8 T cells varied widely in the peripheral blood cells of healthy humans and PD-1 was expressed by the memory CD8 T cells. 2) PD-1 high CD8 T cells in healthy humans did not significantly correlated with the PD-1 high exhausted gene signature of HIV specific human CD8 T cells or chronic LCMV specific CD8 T cells from mice. 3) PD-1 expression did not directly affect the ability of CD8 T cells to secrete cytokines in healthy adults. 4) PD-1 was expressed by the effector memory (TEM) compared to ‘terminally differentiated effector’ (TEMRA) CD8 T cells. 5) Finally, an interesting inverse relationship between CD45RA and PD-1 expression was observed.


systematic_name: M4663
exact_source: GSE26669_2330_200_UP
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus CD4 [GeneID=920] T cells treated with leukocyte costimulatory blockade antibodies.

description_full:
  To elucidate the gene expression “footprint” of antigenically challenged T-cells which had been treated with anti-LFA-1, CTLA4Ig, anti-CD40-ligand antibodies, we performed microarray gene expression analysis comparing the expression profile of costimulatory blockade treated and untreated responder T-cells.


systematic_name: M4664
exact_source: GSE26669_2330_200_DN
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus CD4 [GeneID=920] T cells treated with leukocyte costimulatory blockade antibodies.

description_full:
  To elucidate the gene expression “footprint” of antigenically challenged T-cells which had been treated with anti-LFA-1, CTLA4Ig, anti-CD40-ligand antibodies, we performed microarray gene expression analysis comparing the expression profile of costimulatory blockade treated and untreated responder T-cells.


systematic_name: M4666
exact_source: GSE26669_2331_200_UP
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD8 T cells versus CD8 T cells treated with leukocyte costimulatory blockade antibodies.

description_full:
  To elucidate the gene expression “footprint” of antigenically challenged T-cells which had been treated with anti-LFA-1, CTLA4Ig, anti-CD40-ligand antibodies, we performed microarray gene expression analysis comparing the expression profile of costimulatory blockade treated and untreated responder T-cells.


systematic_name: M4667
exact_source: GSE26669_2331_200_DN
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD8 T cells versus CD8 T cells treated with leukocyte costimulatory blockade antibodies.

description_full:
[cell repeats an earlier one in this file: 307 characters]


systematic_name: M4668
exact_source: GSE26669_2332_200_UP
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus the untreated CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 307 characters]


systematic_name: M4670
exact_source: GSE26669_2332_200_DN
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus the untreated CD8 T cells.

description_full:
[cell repeats an earlier one in this file: 307 characters]


systematic_name: M4672
exact_source: GSE26669_2333_200_UP
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus CD8 T cells treated with leukocyte costimulatory blockade antibodies.

description_full:
[cell repeats an earlier one in this file: 307 characters]


systematic_name: M4673
exact_source: GSE26669_2333_200_DN
source_species_code: MM
GEO_id: GSE26669
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus CD8 T cells treated with leukocyte costimulatory blockade antibodies.

description_full:
[cell repeats an earlier one in this file: 307 characters]


systematic_name: M4674
exact_source: GSE26928_1712_200_UP
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] effector memory T cells.


systematic_name: M4676
exact_source: GSE26928_1712_200_DN
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] effector memory T cells.


systematic_name: M4677
exact_source: GSE26928_1713_200_UP
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] central memory T cells.


systematic_name: M4678
exact_source: GSE26928_1713_200_DN
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] central memory T cells.


systematic_name: M4682
exact_source: GSE26928_1714_200_UP
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] CXCR5+ [GeneID=643] T cells.


systematic_name: M4683
exact_source: GSE26928_1714_200_DN
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus CD4 [GeneID=920] CXCR5+ [GeneID=643] T cells.


systematic_name: M4684
exact_source: GSE26928_1715_200_UP
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] effector memory T cells versus CD4 [GeneID=920] central memory T cells.


systematic_name: M4685
exact_source: GSE26928_1715_200_DN
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] effector memory T cells versus CD4 [GeneID=920] central memory T cells.


systematic_name: M4686
exact_source: GSE26928_1716_200_UP
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] effector memory T cells versus CD4 [GeneID=920] CXCR5+ [GeneID=643] T cells.


systematic_name: M4687
exact_source: GSE26928_1716_200_DN
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] effector memory T cells versus CD4 [GeneID=920] CXCR5+ [GeneID=643] T cells.


systematic_name: M4688
exact_source: GSE26928_1717_200_UP
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of CD4 [GeneID=920] central memory T cells versus CD4 [GeneID=920] CXCR5+ [GeneID=643] T cells.


systematic_name: M4689
exact_source: GSE26928_1717_200_DN
source_species_code: HS
GEO_id: GSE26928
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of CD4 [GeneID=920] central memory T cells versus CD4 [GeneID=920] CXCR5+ [GeneID=643] T cells.


systematic_name: M4691
exact_source: GSE2706_1837_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with R848 for 2 h.

description_full:
  Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently synergize with TLR7, TLR8 or TLR9 in the induction of selected cytokine genes. Upon synergistic stimulation, IL-12, IL-23 and Delta-4 are induced at levels 50-100 fold higher than those induced by optimal concentrations of single agonists, leading to enhanced and sustained TH1 polarizing capacity. Using microarray analysis we show that only 1.5% of the transcripts induced by single TLR agonists are synergistically regulated by combinations of TLR4 and TLR8 agonists. These results identify a combinatorial code by which DCs discriminate pathogens and provide (suggest) a rationale to design adjuvants for TH1 responses. Series_overall_design: 3 untreated, 3 treated with LPS at 2h, 3 treated with LPS at 8h, 3 treated with R848 at 2h, 3 treated with R848 at 8h, 3 treated with LPS + R848 at 2h, 3 treated with LPS + R848 at 8h


systematic_name: M4692
exact_source: GSE2706_1837_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with R848 for 2 h.

description_full:
  Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently synergize with TLR7, TLR8 or TLR9 in the induction of selected cytokine genes. Upon synergistic stimulation, IL-12, IL-23 and Delta-4 are induced at levels 50-100 fold higher than those induced by optimal concentrations of single agonists, leading to enhanced and sustained TH1 polarizing capacity. Using microarray analysis we show that only 1.5% of the transcripts induced by single TLR agonists are synergistically regulated by combinations of TLR4 and TLR8 agonists. These results identify a combinatorial code by which DCs discriminate pathogens and provide (suggest) a rationale to design adjuvants for TH1 responses. Series_overall_design: 3 untreated, 3 treated with LPS at 2h, 3 treated with LPS at 8h, 3 treated with R848 at 2h, 3 treated with R848 at 8h, 3 treated with LPS + R848 at 2h, 3 treated with LPS + R848 at 8h


systematic_name: M4693
exact_source: GSE2706_1838_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with R848 for 8 h.

description_full:
  Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently synergize with TLR7, TLR8 or TLR9 in the induction of selected cytokine genes. Upon synergistic stimulation, IL-12, IL-23 and Delta-4 are induced at levels 50-100 fold higher than those induced by optimal concentrations of single agonists, leading to enhanced and sustained TH1 polarizing capacity. Using microarray analysis we show that only 1.5% of the transcripts induced by single TLR agonists are synergistically regulated by combinations of TLR4 and TLR8 agonists. These results identify a combinatorial code by which DCs discriminate pathogens and provide (suggest) a rationale to design adjuvants for TH1 responses. Series_overall_design: 3 untreated, 3 treated with LPS at 2h, 3 treated with LPS at 8h, 3 treated with R848 at 2h, 3 treated with R848 at 8h, 3 treated with LPS + R848 at 2h, 3 treated with LPS + R848 at 8h


systematic_name: M4694
exact_source: GSE2706_1838_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4695
exact_source: GSE2706_1839_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4696
exact_source: GSE2706_1839_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4698
exact_source: GSE2706_1840_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4701
exact_source: GSE2706_1840_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4702
exact_source: GSE2706_1841_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4703
exact_source: GSE2706_1841_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4704
exact_source: GSE2706_1842_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4705
exact_source: GSE2706_1842_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of unstimulated dendritic cells (DC) at 0 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4706
exact_source: GSE2706_1843_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4708
exact_source: GSE2706_1843_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4712
exact_source: GSE2706_1844_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 8 h versus DCs stimulated with LPS (TLR4 agonist) for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4713
exact_source: GSE2706_1844_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 8 h versus DCs stimulated with LPS (TLR4 agonist) for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4714
exact_source: GSE2706_1845_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4715
exact_source: GSE2706_1845_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4719
exact_source: GSE2706_1846_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4720
exact_source: GSE2706_1846_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4722
exact_source: GSE2706_1847_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4724
exact_source: GSE2706_1847_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4727
exact_source: GSE2706_1848_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4728
exact_source: GSE2706_1848_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4729
exact_source: GSE2706_1849_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulatd with R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4730
exact_source: GSE2706_1849_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulatd with R848 for 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4731
exact_source: GSE2706_1850_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DCs stimulated with LPS (TLR4 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4733
exact_source: GSE2706_1850_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 2 h versus DCs stimulated with LPS (TLR4 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4736
exact_source: GSE2706_1851_200_UP
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


systematic_name: M4738
exact_source: GSE2706_1851_200_DN
source_species_code: HS
GEO_id: GSE2706
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) at 8 h.

description_full:
[cell repeats an earlier one in this file: 1126 characters]


description_brief: Genes up-regulated in comparison of LSK versus lineage negative cells.
systematic_name: M4739
exact_source: GSE27786_2082_200_UP
source_species_code: MM
GEO_id: GSE27786
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_full:
  Each fraction of mouse hematopoietic cells was purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and its gene expression was analyzed.


systematic_name: M4884
exact_source: GSE28237_1750_200_UP
source_species_code: MM
GEO_id: GSE28237
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of naive follicular B cells versus early germinal center (GC) B cells.

description_full:
  Upon immunization with a T cell dependent antigen naive follicular B cells (Fo) are activated and a germinal center reaction is induced. Within the next 2 weeks large germinal centers develop where the process of affinity maturation takes place. To analyze the gene expression profile of resting and activated B cells, follicular B cells (Fo), B cells from early (GC1) and late germinal centers (GC2) were isolated and their gene expression profile compared.


systematic_name: M4885
exact_source: GSE28237_1750_200_DN
source_species_code: MM
GEO_id: GSE28237
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of naive follicular B cells versus early germinal center (GC) B cells.

description_full:
  Upon immunization with a T cell dependent antigen naive follicular B cells (Fo) are activated and a germinal center reaction is induced. Within the next 2 weeks large germinal centers develop where the process of affinity maturation takes place. To analyze the gene expression profile of resting and activated B cells, follicular B cells (Fo), B cells from early (GC1) and late germinal centers (GC2) were isolated and their gene expression profile compared.


systematic_name: M4895
exact_source: GSE2826_1718_200_UP
source_species_code: MM
GEO_id: GSE2826
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of primary splenic B cells from wild type mice versus those from Xid mice.

description_full:
  Bruton's tyrosine kinase (Btk) is important for B lymphocyte development. To identify genes that are differentially expressed in primary B cells lacking functional Btk, splenocytes from X-linked immunodeficiency (Xid), Btk knockout (KO) and immunocompetent CBA mice, were used in microarrays containing more than 12,000 genes and expressed sequence tags (ESTs). We found 4515 transcripts expressed in duplicate experiments in all three strains. Out of these, 38 were differentially expressed genes (21 up-regulated &gt;2 fold and 17 down-regulated &lt;-2 fold) between CBA and Btk defective mice. Ten out of these genes were selected and quantitative Real-Time PCR was conducted for validation and further investigation. Real-Time experiments correlated nicely with the microarray data. No definitive phenotypic difference has previously been reported between Xid and Btk KO mice. We found 7 genes, whose expression differed (&gt;2 fold) between the two strains. Moreover, when the 38 genes, which differed between immunocompetent CBA and Btk defective mice were ranked according to fold-increase, the levels in Btk KO mice were significantly more altered. This suggests that the defect in Btk KO mice is more severe and demonstrates that the mutant Btk protein in Xid mice does not generally function as dominant negative form.


systematic_name: M4897
exact_source: GSE2826_1718_200_DN
source_species_code: MM
GEO_id: GSE2826
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of primary splenic B cells from wild type mice versus those from Xid mice.

description_full:
  Bruton's tyrosine kinase (Btk) is important for B lymphocyte development. To identify genes that are differentially expressed in primary B cells lacking functional Btk, splenocytes from X-linked immunodeficiency (Xid), Btk knockout (KO) and immunocompetent CBA mice, were used in microarrays containing more than 12,000 genes and expressed sequence tags (ESTs). We found 4515 transcripts expressed in duplicate experiments in all three strains. Out of these, 38 were differentially expressed genes (21 up-regulated &gt;2 fold and 17 down-regulated &lt;-2 fold) between CBA and Btk defective mice. Ten out of these genes were selected and quantitative Real-Time PCR was conducted for validation and further investigation. Real-Time experiments correlated nicely with the microarray data. No definitive phenotypic difference has previously been reported between Xid and Btk KO mice. We found 7 genes, whose expression differed (&gt;2 fold) between the two strains. Moreover, when the 38 genes, which differed between immunocompetent CBA and Btk defective mice were ranked according to fold-increase, the levels in Btk KO mice were significantly more altered. This suggests that the defect in Btk KO mice is more severe and demonstrates that the mutant Btk protein in Xid mice does not generally function as dominant negative form.


systematic_name: M4898
exact_source: GSE2826_1719_200_UP
source_species_code: MM
GEO_id: GSE2826
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of primary splenic B cells from wild type mice versus those from BTK [GeneID=695] knockout mice.

description_full:
  Bruton's tyrosine kinase (Btk) is important for B lymphocyte development. To identify genes that are differentially expressed in primary B cells lacking functional Btk, splenocytes from X-linked immunodeficiency (Xid), Btk knockout (KO) and immunocompetent CBA mice, were used in microarrays containing more than 12,000 genes and expressed sequence tags (ESTs). We found 4515 transcripts expressed in duplicate experiments in all three strains. Out of these, 38 were differentially expressed genes (21 up-regulated &gt;2 fold and 17 down-regulated &lt;-2 fold) between CBA and Btk defective mice. Ten out of these genes were selected and quantitative Real-Time PCR was conducted for validation and further investigation. Real-Time experiments correlated nicely with the microarray data. No definitive phenotypic difference has previously been reported between Xid and Btk KO mice. We found 7 genes, whose expression differed (&gt;2 fold) between the two strains. Moreover, when the 38 genes, which differed between immunocompetent CBA and Btk defective mice were ranked according to fold-increase, the levels in Btk KO mice were significantly more altered. This suggests that the defect in Btk KO mice is more severe and demonstrates that the mutant Btk protein in Xid mice does not generally function as dominant negative form.


systematic_name: M4899
exact_source: GSE2826_1719_200_DN
source_species_code: MM
GEO_id: GSE2826
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of primary splenic B cells from wild type mice versus those from BTK [GeneID=695] knockout mice.

description_full:
[cell repeats an earlier one in this file: 1328 characters]


systematic_name: M4900
exact_source: GSE2826_1720_200_UP
source_species_code: MM
GEO_id: GSE2826
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of primary splenic B cells from Xid mice versus those from BTK [GeneID=695] knockout mice.

description_full:
[cell repeats an earlier one in this file: 1328 characters]


systematic_name: M4901
exact_source: GSE2826_1720_200_DN
source_species_code: MM
GEO_id: GSE2826
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of primary splenic B cells from Xid mice versus those from BTK [GeneID=695] knockout mice.

description_full:
[cell repeats an earlier one in this file: 1328 characters]


systematic_name: M4903
exact_source: GSE29614_2205_200_UP
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus that after the vaccination

description_full:
  Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivated influenza (TIV) and live attenuated influenza (LAIV) vaccination in humans, and to identify early gene signatures that predict the magnitude of the antibody responses to influenza vaccination.


systematic_name: M4905
exact_source: GSE29614_2205_200_DN
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus that after the vaccination

description_full:
  Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivated influenza (TIV) and live attenuated influenza (LAIV) vaccination in humans, and to identify early gene signatures that predict the magnitude of the antibody responses to influenza vaccination.


systematic_name: M4906
exact_source: GSE29614_2206_200_UP
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 3 post-vaccination.

description_full:
  Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying the innate responses to the trivalent inactivated influenza (TIV) and live attenuated influenza (LAIV) vaccination in humans, and to identify early gene signatures that predict the magnitude of the antibody responses to influenza vaccination.


systematic_name: M4907
exact_source: GSE29614_2206_200_DN
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 3 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4908
exact_source: GSE29614_2207_200_UP
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4912
exact_source: GSE29614_2207_200_DN
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those from day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4914
exact_source: GSE29614_2208_200_UP
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee at day 3 post-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4915
exact_source: GSE29614_2208_200_DN
source_species_code: HS
GEO_id: GSE29614
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee at day 3 post-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4916
exact_source: GSE29615_2226_200_UP
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4917
exact_source: GSE29615_2226_200_DN
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4918
exact_source: GSE29615_2227_200_UP
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccine pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4919
exact_source: GSE29615_2227_200_DN
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccine pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4921
exact_source: GSE29615_2228_200_UP
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccinee at day 3 post-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4922
exact_source: GSE29615_2228_200_DN
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccinee at day 3 post-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4923
exact_source: GSE29615_2229_200_UP
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4924
exact_source: GSE29615_2229_200_DN
source_species_code: HS
GEO_id: GSE29615
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those post-vaccination.

description_full:
[cell repeats an earlier one in this file: 495 characters]


systematic_name: M4926
exact_source: GSE29617_2201_200_UP
source_species_code: HS
GEO_id: GSE29617
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee before vaccination versus that after the vaccination.

description_full:
  Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying th


systematic_name: M4927
exact_source: GSE29617_2201_200_DN
source_species_code: HS
GEO_id: GSE29617
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee before vaccination versus that after the vaccination.

description_full:
  Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying th


systematic_name: M4928
exact_source: GSE29617_2202_200_UP
source_species_code: HS
GEO_id: GSE29617
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination.

description_full:
  Systems vaccinology has emerged as an interdisciplinary field that combines systems wide measurements and network and predictive modeling applied to vaccinology. Here we used the systems vaccinology approach to study the molecular mechanisms underlying th


systematic_name: M4929
exact_source: GSE29617_2202_200_DN
source_species_code: HS
GEO_id: GSE29617
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4930
exact_source: GSE29617_2203_200_UP
source_species_code: HS
GEO_id: GSE29617
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4931
exact_source: GSE29617_2203_200_DN
source_species_code: HS
GEO_id: GSE29617
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4954
exact_source: GSE29618_2179_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 versus monocytes from influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4955
exact_source: GSE29618_2179_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 versus monocytes from influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4958
exact_source: GSE29618_2180_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (pDC) at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4959
exact_source: GSE29618_2180_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (pDC) at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4961
exact_source: GSE29618_2181_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells (mDC) at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4962
exact_source: GSE29618_2181_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells (mDC) at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4963
exact_source: GSE29618_2182_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (mDC) at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4964
exact_source: GSE29618_2182_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (mDC) at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4966
exact_source: GSE29618_2183_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4968
exact_source: GSE29618_2183_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes from influenza vaccinee at day 7 post-vaccination versus myeloid dendritic cells at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4970
exact_source: GSE29618_2184_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 7 post-vaccination versus myeloid DCs at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4971
exact_source: GSE29618_2184_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 7 post-vaccination versus myeloid DCs at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4972
exact_source: GSE29618_2185_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4973
exact_source: GSE29618_2185_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4975
exact_source: GSE29618_2186_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of monocytes from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4977
exact_source: GSE29618_2186_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4978
exact_source: GSE29618_2187_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of plasmacytoid dendritic cells (pDC) from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4979
exact_source: GSE29618_2187_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of plasmacytoid dendritic cells (pDC) from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4980
exact_source: GSE29618_2188_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 0 versus myeloid DCs at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4981
exact_source: GSE29618_2188_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of plasmacytoid dendritic cells (DC) from influenza vaccinee at day 0 versus myeloid DCs at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4982
exact_source: GSE29618_2189_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4984
exact_source: GSE29618_2189_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4985
exact_source: GSE29618_2190_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4990
exact_source: GSE29618_2190_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4993
exact_source: GSE29618_2191_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of monocytes from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4994
exact_source: GSE29618_2191_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4996
exact_source: GSE29618_2192_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of monocytes from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M4997
exact_source: GSE29618_2192_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5003
exact_source: GSE29618_2194_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of plasmacytoid dendritic cells (pDC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5005
exact_source: GSE29618_2194_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of plasmacytoid dendritic cells (pDC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5007
exact_source: GSE29618_2195_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of myeloid dendritic cells (mDC) from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5008
exact_source: GSE29618_2195_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of myeloid dendritic cells (mDC) from LAIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5009
exact_source: GSE29618_2196_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of myeloid dendritic cells (mDC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5010
exact_source: GSE29618_2196_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of myeloid dendritic cells (mDC) from TIV influenza vaccinee pre-vaccination versus those at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5011
exact_source: GSE29618_2197_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of B cells from LAIV influenza vaccinee at day 7 post-vaccination versus those from TIV influenza vaccinee at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5013
exact_source: GSE29618_2197_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of B cells from LAIV influenza vaccinee at day 7 post-vaccination versus those from TIV influenza vaccinee at day 7 post-vaccination.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5015
exact_source: GSE29618_2198_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of monocytes from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5016
exact_source: GSE29618_2198_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of monocytes from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5018
exact_source: GSE29618_2199_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of plasmacytoid dendritic cells from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5019
exact_source: GSE29618_2199_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of plasmacytoid dendritic cells from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5020
exact_source: GSE29618_2200_200_UP
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes up-regulated in comparison of myeloid dendritic cells from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


systematic_name: M5022
exact_source: GSE29618_2200_200_DN
source_species_code: HS
GEO_id: GSE29618
contributor: Jernej Godec
contrib_organization: Dana-Farber Cancer Institute
description_brief:
  Genes down-regulated in comparison of myeloid dendritic cells from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7.

description_full:
[cell repeats an earlier one in this file: 255 characters]


