# gene_set_details

systematic_name: M47854
exact_source: N01465
external_details_URL: https://www.kegg.jp/entry/N01465
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: FANCD2+FANCI+Ub -> FAN1 == SLX+MUS81+EME1 == ERCC4+ERCC1+SNM1A -> REV1,REV3L,REV7

description_full:
  Lesion bypass by TLS and DSB formation. Pathway ID: N01465. Pathway type: Reference. Pathway class: nt06508 Interstrand crosslink repair.


systematic_name: M47855
exact_source: N01466
external_details_URL: https://www.kegg.jp/entry/N01466
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: FANCD2+FANCI+Ub -> BRCA1+BARD1 == BRIP1 == BRCA2+PALB2+DSS1 == RPA == HROB+MCM8+MCM9

description_full:
  Homologous recombination in ICLR. Pathway ID: N01466. Pathway type: Reference. Pathway class: nt06508 Interstrand crosslink repair.


description_brief: Pathway Definition from KEGG: Palmitate -- (ACSL,ACSBG) >> CPT1A/B/C >> CPT2 -> Palmitoyl-CoA
systematic_name: M47626
exact_source: N00765
external_details_URL: https://www.kegg.jp/entry/N00765
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  beta-Oxidation, acyl-CoA synthesis. Pathway ID: N00765. Pathway type: Reference. Pathway class: nt06020 beta-Oxidation in mitochondria.


description_brief: Pathway Definition from KEGG: Ca2+ -> PTK2B -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47592
exact_source: N00538
external_details_URL: https://www.kegg.jp/entry/N00538
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+-PYK2-RAS-ERK signaling pathway. Pathway ID: N00538. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


systematic_name: M47618
exact_source: N00699
external_details_URL: https://www.kegg.jp/entry/N00699
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: G13092+CDP-Rib-ol -- FKTN >> FKRP >> TMEM5 >> B4GAT1 >> LARGE1/2 -> G13099

description_full:
  Mannose type O-glycan biosynthesis, FKTN to LARGE. Pathway ID: N00699. Pathway type: Reference. Pathway class: nt06013 O-Glycan biosynthesis.


systematic_name: M47945
exact_source: N01624
external_details_URL: https://www.kegg.jp/entry/N01624
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Farnesyl-PP -- FDFT1 >> SQLE >> LSS >> CYP51A1 >> (TM7SF2,LBR) >> MSMO1 >> NSDHL >> HSD17B7 >> DHCR24 >> EBP >> SC5D -> 7-DHC -- DHCR7 -> Cholesterol

description_full:
  Cholesterol biosynthesis. Pathway ID: N01624. Pathway type: Reference. Pathway class: nt06034 Cholesterol biosynthesis.


description_brief: Pathway Definition from KEGG: FG -- (F2a,((MBL2,COLEC10/11,FCN)+MASP1)) -> Fibrin
systematic_name: M47879
exact_source: N01502
external_details_URL: https://www.kegg.jp/entry/N01502
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Lectin pathway of coagulation cascade, fibrinogen to fibrin. Pathway ID: N01502. Pathway type: Reference. Pathway class: nt06171 SARS coronavirus 2 (SARS-CoV-2).


description_brief: Pathway Definition from KEGG: FGF -> FGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47379
exact_source: N00019
external_details_URL: https://www.kegg.jp/entry/N00019
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FGF-FGFR-RAS-ERK signaling pathway. Pathway ID: N00019. Pathway type: Reference. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: FGF -> FGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47396
exact_source: N00037
external_details_URL: https://www.kegg.jp/entry/N00037
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FGF-FGFR-PI3K signaling pathway. Pathway ID: N00037. Pathway type: Reference. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: FGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47380
exact_source: N00020
external_details_URL: https://www.kegg.jp/entry/N00020
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified FGFR to RAS-ERK signaling pathway. Pathway ID: N00020. Pathway type: Variant. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: FGFR* -> PI3K -> PIP3 -> AKT -> MTOR
systematic_name: M47397
exact_source: N00038
external_details_URL: https://www.kegg.jp/entry/N00038
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified FGFR to PI3K signaling pathway. Pathway ID: N00038. Pathway type: Variant. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: FGFR3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> MSK1 -> MYC
systematic_name: M47373
exact_source: N00011
external_details_URL: https://www.kegg.jp/entry/N00011
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated FGFR3 to RAS-ERK signaling pathway. Pathway ID: N00011. Pathway type: Variant. Pathway class: nt06265 Bladder cancer.


description_brief: Pathway Definition from KEGG: (MRAS+SHOC2+PP1) -> RAF
systematic_name: M47933
exact_source: N01598
external_details_URL: https://www.kegg.jp/entry/N01598
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of GF-RTK-RAS-ERK signaling, MRAS-SHOC2-PP1 holophosphatase. Pathway ID: N01598. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


description_brief: Pathway Definition from KEGG: (NLRP1+PYCARD) -> CASP1 -> (IL1B,IL18)
systematic_name: M48984
exact_source: N01567
external_details_URL: https://www.kegg.jp/entry/N01567
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  NLRP1 inflammasome signaling pathway. Pathway ID: N01567. Pathway type: Reference. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: (CARD8,GPSM3,IRGM,NO) -| (NLRP3+PYCARD)
systematic_name: M48985
exact_source: N01568
external_details_URL: https://www.kegg.jp/entry/N01568
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of NLRP3 inflammasome signaling pathway, NLRP3 inhibition. Pathway ID: N01568. Pathway type: Reference. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: EBNA2 == SNW1 -> RBPJ => (LMP1,CR2,HES1,FCER2,RUNX3,MYC)
systematic_name: M47478
exact_source: N00225
external_details_URL: https://www.kegg.jp/entry/N00225
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA2 to RBP-Jk-mediated transcription. Pathway ID: N00225. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: SifA -> PLEKHM2 == (KIF5+KLC) == (TUBA+TUBB)
systematic_name: M47775
exact_source: N01298
external_details_URL: https://www.kegg.jp/entry/N01298
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Salmonella SifA to microtubule plus-end directed transport. Pathway ID: N01298. Pathway type: Pathogen. Pathway class: nt06125 Membrane trafficking (bacteria).


description_brief: Pathway Definition from KEGG: FLT3* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47366
exact_source: N00004
external_details_URL: https://www.kegg.jp/entry/N00004
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Duplication or mutation-activated FLT3 to RAS-ERK signaling pathway. Pathway ID: N00004. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: FLT3* -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47390
exact_source: N00031
external_details_URL: https://www.kegg.jp/entry/N00031
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Duplication or mutation-activated FLT3 to RAS-PI3K signaling pathway. Pathway ID: N00031. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: FLT3* -> STAT5 => PIM1/2
systematic_name: M48986
exact_source: N00054
external_details_URL: https://www.kegg.jp/entry/N00054
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway. Pathway ID: N00054. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47474
exact_source: N00217
external_details_URL: https://www.kegg.jp/entry/N00217
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FLT3LG-FLT3-RAS-ERK signaling pathway. Pathway ID: N00217. Pathway type: Reference. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: FLT3LG -> FLT3 -> GRB2 -> SOS -> RAS -> PI3K -> PIP3 -> AKT -> MTOR
systematic_name: M47475
exact_source: N00218
external_details_URL: https://www.kegg.jp/entry/N00218
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FLT3LG-FLT3-RAS-PI3K signaling pathway. Pathway ID: N00218. Pathway type: Reference. Pathway class: nt06262 Pancreatic cancer.


description_brief: Pathway Definition from KEGG: ICOSLG -> ICOS -> PI3Kdelta -> PIP3 -> AKT
systematic_name: M47972
exact_source: N01696
external_details_URL: https://www.kegg.jp/entry/N01696
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ICOSLG/ICOS-PI3K signaling pathway. Pathway ID: N01696. Pathway type: Reference. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> RHOG -> (DOCK1+ELMO) -> RAC
systematic_name: M47655
exact_source: N00951
external_details_URL: https://www.kegg.jp/entry/N00951
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ITGA/B-RHOG-RAC signaling pathway. Pathway ID: N00951. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


systematic_name: M47724
exact_source: N01080
external_details_URL: https://www.kegg.jp/entry/N01080
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> (PTK2+PXN+ILK) -> (TLN+ACTN1/4+VCN) -> (ACTB,ACTG1)

description_full:
  ITGA/B-TALIN/VINCULIN signaling pathway. Pathway ID: N01080. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> PTK2 -> ARHGEF28 -> RHOA
systematic_name: M47720
exact_source: N01072
external_details_URL: https://www.kegg.jp/entry/N01072
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ITGA/B-RhoGEF-RhoA signaling pathway. Pathway ID: N01072. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> SRC -> ARHGAP35 -| RHOA
systematic_name: M47537
exact_source: N00393
external_details_URL: https://www.kegg.jp/entry/N00393
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ITGA/B-RhoGAP-RhoA signaling pathway. Pathway ID: N00393. Pathway type: Reference. Pathway class: nt06167 Human cytomegalovirus (HCMV).


systematic_name: M47718
exact_source: N01068
external_details_URL: https://www.kegg.jp/entry/N01068
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> (SRC,PTK2) -> (PXN,CRK+BCAR1) -> (DOCK1+ELMO1) -> RAC

description_full:
  ITGA/B-FAK-RAC signaling pathway. Pathway ID: N01068. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: FN1 -> (ITGA+ITGB) -> (SRC,PTK2) -> PXN -> (GIT2+ARHGEF7) -> CDC42
systematic_name: M47719
exact_source: N01070
external_details_URL: https://www.kegg.jp/entry/N01070
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ITGA/B-FAK-CDC42 signaling pathway. Pathway ID: N01070. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: TARDBP* -| CxI -> Q
systematic_name: M47741
exact_source: N01136
external_details_URL: https://www.kegg.jp/entry/N01136
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant TDP43 to electron transfer in Complex I. Pathway ID: N01136. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: RNA -> RIGI -> MAVS -> IKK -> NFKBIA -> NFKB => (IFNA,IFNB1)
systematic_name: M47616
exact_source: N00688
external_details_URL: https://www.kegg.jp/entry/N00688
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  RIG-I-NFKB signaling pathway. Pathway ID: N00688. Pathway type: Reference. Pathway class: nt06519 RLR signaling.


systematic_name: M47576
exact_source: N00469
external_details_URL: https://www.kegg.jp/entry/N00469
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RNA -> RIGI -> MAVS -> TRAF3 -> (TANK+NAP1+SINTBAD) -> (TBK1+IKBKE) -> (IRF7,IRF3) => (IFNA,IFNB1)

description_full:
  RIG-I-IRF7/3 signaling pathway. Pathway ID: N00469. Pathway type: Reference. Pathway class: nt06519 RLR signaling.


description_brief: Pathway Definition from KEGG: EML4-ALK -> RAS -> RAF -> MEK -> ERK -> CCND1
systematic_name: M47369
exact_source: N00007
external_details_URL: https://www.kegg.jp/entry/N00007
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EML4-ALK fusion kinase to RAS-ERK signaling pathway. Pathway ID: N00007. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: EML4-ALK -> JAK3 -> STAT3,STAT5
systematic_name: M48987
exact_source: N00105
external_details_URL: https://www.kegg.jp/entry/N00105
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EML4-ALK fusion kinase to Jak-STAT signaling pathway. Pathway ID: N00105. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: EML4-ALK -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47405
exact_source: N00047
external_details_URL: https://www.kegg.jp/entry/N00047
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EML4-ALK fusion kinase to PI3K signaling pathway. Pathway ID: N00047. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


systematic_name: M47384
exact_source: N00025
external_details_URL: https://www.kegg.jp/entry/N00025
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: EML4-ALK -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1

description_full:
  EML4-ALK fusion kinase to PLCG-ERK signaling pathway. Pathway ID: N00025. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: mTORC1 -> ULK1_complex -> PI3KC3-C1
systematic_name: M47457
exact_source: N00155
external_details_URL: https://www.kegg.jp/entry/N00155
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagy-vesicle nucleation/elongation/maturation, mTORC1-PI3KC3-C1. Pathway ID: N00155. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: BCR-ABL -> (CRKL+CBL+CRK) -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47406
exact_source: N00048
external_details_URL: https://www.kegg.jp/entry/N00048
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  BCR-ABL fusion kinase to PI3K signaling pathway. Pathway ID: N00048. Pathway type: Variant. Pathway class: nt06276 Chronic myeloid leukemia.


description_brief: Pathway Definition from KEGG: BCR-ABL -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47364
exact_source: N00002
external_details_URL: https://www.kegg.jp/entry/N00002
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  BCR-ABL fusion kinase to RAS-ERK signaling pathway. Pathway ID: N00002. Pathway type: Variant. Pathway class: nt06276 Chronic myeloid leukemia.


description_brief: Pathway Definition from KEGG: KS -- GALNS >> GLB1 >> GNS >> HEXA/B -> G01391
systematic_name: M47609
exact_source: N00623
external_details_URL: https://www.kegg.jp/entry/N00623
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Keratan sulfate degradation. Pathway ID: N00623. Pathway type: Reference. Pathway class: nt06012 Glycosaminoglycan degradation.


description_brief: Pathway Definition from KEGG: SopB -> ARHGEF26 -> RHOG -> ELMO
systematic_name: M48988
exact_source: N01133
external_details_URL: https://www.kegg.jp/entry/N01133
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Salmonella SopB to RhoG signaling pathway. Pathway ID: N01133. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: Arg+Gly -- GATM >> GAMT -> Cr -- CK -> Crn
systematic_name: M47940
exact_source: N01612
external_details_URL: https://www.kegg.jp/entry/N01612
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Creatine pathway. Pathway ID: N01612. Pathway type: Reference. Pathway class: nt06033 Glycine, serine and arginine metabolism.


description_brief: Pathway Definition from KEGG: BORCS == ARL8 == PLEKHM2 == (KIF5+KLC) == (TUBA+TUBB)
systematic_name: M47774
exact_source: N01297
external_details_URL: https://www.kegg.jp/entry/N01297
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Arl8-regulated microtubule plus-end directed transport. Pathway ID: N01297. Pathway type: Reference. Pathway class: nt06125 Membrane trafficking (bacteria).


description_brief: Pathway Definition from KEGG: BMP9/10 -> ((BMPR2,ACVR2A)+ACVRL1) -> (SMAD1,SMAD5,SMAD9) == SMAD4
systematic_name: M47822
exact_source: N01426
external_details_URL: https://www.kegg.jp/entry/N01426
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  BMP9/10 signaling pathway. Pathway ID: N01426. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: MSTN -> (ACVR2B+(ACVR1B,TGFBR1)) -> (SMAD1,SMAD5,SMAD9) == SMAD4
systematic_name: M47847
exact_source: N01457
external_details_URL: https://www.kegg.jp/entry/N01457
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Myostatin signaling pathway. Pathway ID: N01457. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: AMH -> (AMHR2+(ACVR1,BMPR1A,BMPR1B)) -> (SMAD1,SMAD5,SMAD9) == SMAD4
systematic_name: M47844
exact_source: N01454
external_details_URL: https://www.kegg.jp/entry/N01454
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  AMH signaling pathway. Pathway ID: N01454. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: GH -> GHR -> JAK2 -> STAT5 => IGF1
systematic_name: M47646
exact_source: N00907
external_details_URL: https://www.kegg.jp/entry/N00907
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  GH-Jak-STAT signaling pathway. Pathway ID: N00907. Pathway type: Reference. Pathway class: nt06324 GHRH-GH-IGF signaling.


systematic_name: M47647
exact_source: N00910
external_details_URL: https://www.kegg.jp/entry/N00910
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: GHRH -> GHRHR -> GNAS -> ADCY -> cAMP -> PKA -> CREB => POU1F1 => (GH1,GH2)

description_full:
  GHRHR-PKA-GH signaling pathway. Pathway ID: N00910. Pathway type: Reference. Pathway class: nt06324 GHRH-GH-IGF signaling.


systematic_name: M47716
exact_source: N01066
external_details_URL: https://www.kegg.jp/entry/N01066
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)

description_full:
  ARNO-ARF-ACTB_G signaling pathway. Pathway ID: N01066. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: Cys+Glu -- (GCLC+GCLM) >> GSS -> GSH -- GPX -> GSSG
systematic_name: M47926
exact_source: N01589
external_details_URL: https://www.kegg.jp/entry/N01589
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Glutathione biosynthesis. Pathway ID: N01589. Pathway type: Reference. Pathway class: nt06026 Glutathione biosynthesis.


description_brief: Pathway Definition from KEGG: (RABGEF1+RABEP1) -> RAB5 -> (PIK3C3+PIK3R4) -> PI3P -> EEA1
systematic_name: M47778
exact_source: N01302
external_details_URL: https://www.kegg.jp/entry/N01302
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Early endosomal fusion. Pathway ID: N01302. Pathway type: Reference. Pathway class: nt06125 Membrane trafficking (bacteria).


description_brief: Pathway Definition from KEGG: Met -- MAT >> (GNMT,DNMT) >> AHCY -> Hcy+Adenosine
systematic_name: M47939
exact_source: N01607
external_details_URL: https://www.kegg.jp/entry/N01607
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Methionine degradation. Pathway ID: N01607. Pathway type: Reference. Pathway class: nt06030 Methionine metabolism.


description_brief: Pathway Definition from KEGG: Glycogen -- AMY >> (MGAM,GAA,GANC) -> Glc
systematic_name: M47622
exact_source: N00720
external_details_URL: https://www.kegg.jp/entry/N00720
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Glycogen degradation (amylase). Pathway ID: N00720. Pathway type: Reference. Pathway class: nt06017 Glycogen metabolism.


description_brief: Pathway Definition from KEGG: UL33 -> (GNAI,GNAO) -| ADCY -> cAMP -> PKA -> CREB
systematic_name: M47553
exact_source: N00412
external_details_URL: https://www.kegg.jp/entry/N00412
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCMV UL33 to GNAI-AC-PKA signaling pathway. Pathway ID: N00412. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


systematic_name: M47543
exact_source: N00402
external_details_URL: https://www.kegg.jp/entry/N00402
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: US28 -> GNAQ -> PLCB -> IP3 -> Ca2+ -> CALM == CN -> NFAT => (CXCL8,PTGS2)

description_full:
  HCMV US28 to GNAQ-PLCB/G-calcineurin signaling pathway. Pathway ID: N00402. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: UL33 -> (GNAQ,GNA11) -> PLCB
systematic_name: M47548
exact_source: N00407
external_details_URL: https://www.kegg.jp/entry/N00407
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCMV UL33 to GNAQ-PLCB/G-calcineurin signaling pathway. Pathway ID: N00407. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: GNAS* -> ADCY -> cAMP -> PKA -> CREB -> ACTH
systematic_name: M47520
exact_source: N00326
external_details_URL: https://www.kegg.jp/entry/N00326
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated GNAS to CRHR-PKA-ACTH signaling pathway. Pathway ID: N00326. Pathway type: Variant. Pathway class: nt06360 Cushing syndrome.


systematic_name: M47515
exact_source: N00321
external_details_URL: https://www.kegg.jp/entry/N00321
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: GNAS* -> ADCY -> cAMP -> PKA -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol

description_full:
  Mutation-activated GNAS to ACTH-cortisol signaling pathway. Pathway ID: N00321. Pathway type: Variant. Pathway class: nt06360 Cushing syndrome.


systematic_name: M47459
exact_source: N00157
external_details_URL: https://www.kegg.jp/entry/N00157
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: vGPCR -> GNB/G -> RAS -> RAF1 -> MEK -> ERK -> (HIF1A,FOS,JUN) => (VEGFA,PDGFB,ANGPT2)

description_full:
  KSHV vGPCR to GNB/G-ERK signaling pathway. Pathway ID: N00157. Pathway type: Pathogen. Pathway class: nt06224 CXCR signaling.


description_brief: Pathway Definition from KEGG: UL33 -> GNB/G -> RHOA -> MAP2K6 -> p38 -> CREB
systematic_name: M47550
exact_source: N00409
external_details_URL: https://www.kegg.jp/entry/N00409
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCMV UL33 to GNB/G-Rho signaling pathway. Pathway ID: N00409. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


systematic_name: M47541
exact_source: N00400
external_details_URL: https://www.kegg.jp/entry/N00400
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: US28 -> GNB/G -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB => (IL6,CXCL8)

description_full:
  HCMV US28 to GNB/G-PI3K-NFKB signaling pathway. Pathway ID: N00400. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: vGPCR -> GNB/G -> PI3Kgamma -> PIP3 -> AKT -> MTOR
systematic_name: M47460
exact_source: N00158
external_details_URL: https://www.kegg.jp/entry/N00158
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway. Pathway ID: N00158. Pathway type: Pathogen. Pathway class: nt06224 CXCR signaling.


systematic_name: M47466
exact_source: N00178
external_details_URL: https://www.kegg.jp/entry/N00178
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: vGPCR -> GNB/G -> PI3Kgamma -> PREX1 -> RAC1 -> JNK -> NFKB => (IL6,CXCL8)

description_full:
  KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway. Pathway ID: N00178. Pathway type: Pathogen. Pathway class: nt06224 CXCR signaling.


description_brief: Pathway Definition from KEGG: Glc-6P -- GPI >> MPI >> PMM1/2 >> GMPP >> DPM1/2/3 -> Man-P-Dol
systematic_name: M47613
exact_source: N00667
external_details_URL: https://www.kegg.jp/entry/N00667
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  N-Glycan precursor biosynthesis, Glc-6P to Man-P-Dol. Pathway ID: N00667. Pathway type: Reference. Pathway class: nt06015 N-Glycan biosynthesis.


systematic_name: M47623
exact_source: N00731
external_details_URL: https://www.kegg.jp/entry/N00731
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Glc-6P -- GPI >> PFK >> ALDO >> GAPDH >> PGK1/2 >> (PGAM,BPGM) >> ENO1/2/3/4 >> (PKLR,PKM) >> (LDH,LDHAL6) -> Lactate

description_full:
  Glycolysis. Pathway ID: N00731. Pathway type: Reference. Pathway class: nt06017 Glycogen metabolism.


description_brief: Pathway Definition from KEGG: (RSPO+LGR4/5/6)) -| (ZNRF3,RNF43) -| FZD
systematic_name: M47833
exact_source: N01440
external_details_URL: https://www.kegg.jp/entry/N01440
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Wnt signaling modulation, LGR/RSPO. Pathway ID: N01440. Pathway type: Reference. Pathway class: nt06505 WNT signaling.


description_brief: Pathway Definition from KEGG: (DLL,JAG) -> NOTCH -> (NICD+RBPJ) => (HES1,HEY1)
systematic_name: M47423
exact_source: N00086
external_details_URL: https://www.kegg.jp/entry/N00086
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Notch signaling pathway. Pathway ID: N00086. Pathway type: Reference. Pathway class: nt06511 NOTCH signaling.


systematic_name: M47424
exact_source: N00087
external_details_URL: https://www.kegg.jp/entry/N00087
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (DLL,JAG) -> (NOTCH1*,NOTCH4*) -> (NICD+RBPJ) => (ERBB2,HES1,HES5,HEY,FLT4)

description_full:
  NOTCH-overexpression to Notch signaling pathway. Pathway ID: N00087. Pathway type: Variant. Pathway class: nt06270 Breast cancer.


description_brief: Pathway Definition from KEGG: Glutamate -> NMDAR -> Ca2+
systematic_name: M47667
exact_source: N00970
external_details_URL: https://www.kegg.jp/entry/N00970
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Transport of calcium. Pathway ID: N00970. Pathway type: Reference. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47656
exact_source: N00953
external_details_URL: https://www.kegg.jp/entry/N00953
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -> PKC -| TRPC3 -> Ca2+

description_full:
  mGluR1-TRPC3 signaling pathway. Pathway ID: N00953. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


systematic_name: M47659
exact_source: N00957
external_details_URL: https://www.kegg.jp/entry/N00957
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> (ITPR1+(ATXN2*,ATXN3*)) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS

description_full:
  Mutation-caused abberant ATXN2/3 to mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N00957. Pathway type: Variant. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: (PDL1,PDL2) -> PDCD1 -> SHP1/2 -| PI3Kdelta
systematic_name: M47757
exact_source: N01165
external_details_URL: https://www.kegg.jp/entry/N01165
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PDL/PD1-SHP-PI3K signaling pathway. Pathway ID: N01165. Pathway type: Reference. Pathway class: nt06530 PI3K signaling.


systematic_name: M47676
exact_source: N00985
external_details_URL: https://www.kegg.jp/entry/N00985
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> (ITPR+HTT*) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

description_full:
  Mutation-caused aberrant Htt to mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N00985. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


systematic_name: M47675
exact_source: N00984
external_details_URL: https://www.kegg.jp/entry/N00984
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

description_full:
  mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N00984. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: LANA -| GSK3B -| CTNNB1 -> TCF/LEF => CCND1
systematic_name: M47465
exact_source: N00175
external_details_URL: https://www.kegg.jp/entry/N00175
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV LANA to Wnt signaling pathway. Pathway ID: N00175. Pathway type: Pathogen. Pathway class: nt06505 WNT signaling.


description_brief: Pathway Definition from KEGG: (GSK3B+APC) // AXIN* // CTNNB1 -> TCF/LEF => (MYC,CCND1)
systematic_name: M47486
exact_source: N00242
external_details_URL: https://www.kegg.jp/entry/N00242
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated AXIN to Wnt signaling pathway. Pathway ID: N00242. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: Zn2+ -> GSK3B -> MAPT -| (TUBA+TUBB)
systematic_name: M47813
exact_source: N01403
external_details_URL: https://www.kegg.jp/entry/N01403
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Zn to anterograde axonal transport. Pathway ID: N01403. Pathway type: Env factor. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: G00007+Glc-P-Dol -- ALG6 >> ALG8 >> ALG10 >> (STT+OST) -> G00009
systematic_name: M47614
exact_source: N00681
external_details_URL: https://www.kegg.jp/entry/N00681
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  N-Glycan precursor biosynthesis, ALG6 to OST. Pathway ID: N00681. Pathway type: Reference. Pathway class: nt06015 N-Glycan biosynthesis.


description_brief: Pathway Definition from KEGG: UBQLN2* -| (Protein+UB) -- 26S -> Peptide
systematic_name: M47749
exact_source: N01146
external_details_URL: https://www.kegg.jp/entry/N01146
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated UBQLN2 to 26S proteasome-mediated protein degradation. Pathway ID: N01146. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: HTT* -| (CREB+TAF4) => PPARGC1A
systematic_name: M47674
exact_source: N00981
external_details_URL: https://www.kegg.jp/entry/N00981
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to CREB-mediated transcription. Pathway ID: N00981. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


systematic_name: M47677
exact_source: N00987
external_details_URL: https://www.kegg.jp/entry/N00987
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: HTT* // DLG4 -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  Mutation-caused aberrant Htt to transport of calcium. Pathway ID: N00987. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* // (HIP1+IFT57) -> CASP8 -> CASP3
systematic_name: M48989
exact_source: N00983
external_details_URL: https://www.kegg.jp/entry/N00983
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to extrinsic apoptotic pathway. Pathway ID: N00983. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* -> MLK2 -> MKK7 -> JNK
systematic_name: M47680
exact_source: N00992
external_details_URL: https://www.kegg.jp/entry/N00992
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to TNF-JNK signaling pathway. Pathway ID: N00992. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* -> JNK3 -| (KIF5+KLC) == (TUBA+TUBB)
systematic_name: M47672
exact_source: N00979
external_details_URL: https://www.kegg.jp/entry/N00979
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to anterograde axonal transport. Pathway ID: N00979. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* -| 26S
systematic_name: M47714
exact_source: N01061
external_details_URL: https://www.kegg.jp/entry/N01061
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to 26S proteasome-mediated protein degradation. Pathway ID: N01061. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* // REST == (SIN3A+RCOR1+(HDAC1,HDAC2)) =| BDNF
systematic_name: M47673
exact_source: N00980
external_details_URL: https://www.kegg.jp/entry/N00980
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to REST-mediated transcriptional repression. Pathway ID: N00980. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* -| CxII -> QH2
systematic_name: M48990
exact_source: N00989
external_details_URL: https://www.kegg.jp/entry/N00989
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to electron transfer in Complex II. Pathway ID: N00989. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* -| CxIII -> CytC
systematic_name: M47679
exact_source: N00991
external_details_URL: https://www.kegg.jp/entry/N00991
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to electron transfer in Complex III. Pathway ID: N00991. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: HTT* -| (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1)
systematic_name: M47681
exact_source: N00993
external_details_URL: https://www.kegg.jp/entry/N00993
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to autophagy-vesicle nucleation. Pathway ID: N00993. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


description_brief: Pathway Definition from KEGG: (HTT*+HAP1) -| (DCTN+DNAH+DNAI+DNALI1+DNAL) == (TUBA+TUBB)
systematic_name: M47670
exact_source: N00977
external_details_URL: https://www.kegg.jp/entry/N00977
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Htt to retrograde axonal transport. Pathway ID: N00977. Pathway type: Variant. Pathway class: nt06461 Huntington disease.


systematic_name: M47875
exact_source: N01496
external_details_URL: https://www.kegg.jp/entry/N01496
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (C3b+Bb) -- (CFH,(CD55+CR1)) -> C3b -- (CFI+(CFH,CR1,CD46)) -> iC3b -- (CFI+CR1) -> C3dg -- Plasmin -> C3d

description_full:
  Alternative pathway of complement cascade, C3b breakdown. Pathway ID: N01496. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


description_brief: Pathway Definition from KEGG: CFHR -| CFH
systematic_name: M47880
exact_source: N01504
external_details_URL: https://www.kegg.jp/entry/N01504
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of complement cascade, CFHR. Pathway ID: N01504. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


description_brief: Pathway Definition from KEGG: NRG // ERBB4*
systematic_name: M48991
exact_source: N01164
external_details_URL: https://www.kegg.jp/entry/N01164
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated ERBB4 to NRG-ERBB4-PI3K signaling pathway. Pathway ID: N01164. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: NRG -> ERBB4 -> PI3K -> PIP3 -> AKT
systematic_name: M47756
exact_source: N01163
external_details_URL: https://www.kegg.jp/entry/N01163
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  NRG-ERBB4-PI3K signaling pathway. Pathway ID: N01163. Pathway type: Reference. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: HIF1A == ARNT => (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)
systematic_name: M47421
exact_source: N00079
external_details_URL: https://www.kegg.jp/entry/N00079
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIF-1 signaling pathway. Pathway ID: N00079. Pathway type: Reference. Pathway class: nt06264 Renal cell carcinoma.


description_brief: Pathway Definition from KEGG: E5 -| (MHCI+BCAP31)
systematic_name: M47530
exact_source: N00364
external_details_URL: https://www.kegg.jp/entry/N00364
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HPV E5 to antigen processing and presentation by MHC class I molecules. Pathway ID: N00364. Pathway type: Pathogen. Pathway class: nt06166 Human papillomavirus (HPV).


description_brief: Pathway Definition from KEGG: P12 -| (MHCI+B2M)
systematic_name: M47582
exact_source: N00492
external_details_URL: https://www.kegg.jp/entry/N00492
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 p12 to antigen processing and presentation by MHC class I molecules. Pathway ID: N00492. Pathway type: Pathogen. Pathway class: nt06229 MHC presentation.


description_brief: Pathway Definition from KEGG: RAS // (RASSF1*+RASSF5) // STK4
systematic_name: M47433
exact_source: N00097
external_details_URL: https://www.kegg.jp/entry/N00097
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Loss of RASSF1 to RAS-RASSF1 signaling pathway. Pathway ID: N00097. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: Metals -> ROS -> RAS -> RAF -> MEK -> ERK -> AP1
systematic_name: M47815
exact_source: N01408
external_details_URL: https://www.kegg.jp/entry/N01408
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Metals to RAS-ERK signaling pathway. Pathway ID: N01408. Pathway type: Env factor. Pathway class: nt06210 ERK signaling.


description_brief: Pathway Definition from KEGG: XIAP -| (RIPK1+RIPK3+FADD+CASP8)
systematic_name: M48992
exact_source: N01583
external_details_URL: https://www.kegg.jp/entry/N01583
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of extrinsic apoptotic pathway, XIAP. Pathway ID: N01583. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: MIR2 -| (ICAM1,CD86,MICA,MICB,CLEC2B,IFNGR1)
systematic_name: M47469
exact_source: N00185
external_details_URL: https://www.kegg.jp/entry/N00185
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV MIR2 to cell surface molecule-endocytosis. Pathway ID: N00185. Pathway type: Pathogen. Pathway class: nt06229 MHC presentation.


systematic_name: M47630
exact_source: N00804
external_details_URL: https://www.kegg.jp/entry/N00804
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Acyl-CoA(n) -- (ACADM,ACADL,ACADVL,ACADS,ACADSB) >> ((ECHS1+HADH),HADHA) >> (ACAA2,HADHB,ACAT1) -> Acyl-CoA(n-2)

description_full:
  beta-Oxidation. Pathway ID: N00804. Pathway type: Reference. Pathway class: nt06020 beta-Oxidation in mitochondria.


description_brief: Pathway Definition from KEGG: DS -- IDS >> IDUA >> ARSB >> HYAL -> G00872
systematic_name: M47607
exact_source: N00610
external_details_URL: https://www.kegg.jp/entry/N00610
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Dermatan sulfate degradation. Pathway ID: N00610. Pathway type: Reference. Pathway class: nt06012 Glycosaminoglycan degradation.


description_brief: Pathway Definition from KEGG: HS -- IDS >> IDUA >> SGSH >> HGSNAT >> NAGLU >> GUSB >> GNS -> G02632
systematic_name: M47608
exact_source: N00615
external_details_URL: https://www.kegg.jp/entry/N00615
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Heparan sulfate degradation. Pathway ID: N00615. Pathway type: Reference. Pathway class: nt06012 Glycosaminoglycan degradation.


systematic_name: M47452
exact_source: N00150
external_details_URL: https://www.kegg.jp/entry/N00150
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IFNA,IFNB1) -> (IFNAR1+IFNAR2) -> (JAK1,TYK2) -> (STAT1+STAT2+IRF9) => (IRF7,EIF2AK2)

description_full:
  Type I IFN signaling pathway. Pathway ID: N00150. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


systematic_name: M47908
exact_source: N01558
external_details_URL: https://www.kegg.jp/entry/N01558
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IFNA,IFNB1,IFNW1,IFNK,IFNE) -> (IFNAR1+IFNAR2) -> (JAK1+TYK2) -> (STAT1+STAT2) == IRF9

description_full:
  Type I interferon to Jak-STAT signaling pathway. Pathway ID: N01558. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.


description_brief: Pathway Definition from KEGG: IFN -> IFNR -> JAKs -> STAT+IRF9 => (RIPK1+RIPK3)
systematic_name: M47964
exact_source: N01662
external_details_URL: https://www.kegg.jp/entry/N01662
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  IFN-RIPK1/3 signaling pathway. Pathway ID: N01662. Pathway type: Reference. Pathway class: nt06527 Necroptosis.


systematic_name: M47909
exact_source: N01559
external_details_URL: https://www.kegg.jp/entry/N01559
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: IFNG -> (IFNGR1,IFNGR2) -> (JAK1+JAK2) -> (STAT1,STAT3) => (IL27,IFNA,IFNG)

description_full:
  Type II interferon to Jak-STAT signaling pathway. Pathway ID: N01559. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.


description_brief: Pathway Definition from KEGG: IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
systematic_name: M47467
exact_source: N00182
external_details_URL: https://www.kegg.jp/entry/N00182
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  IGF-IGFR-PI3K-NFKB signaling pathway. Pathway ID: N00182. Pathway type: Reference. Pathway class: nt06214 PI3K signaling.


systematic_name: M47603
exact_source: N00582
external_details_URL: https://www.kegg.jp/entry/N00582
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: IGF1 -> IGF1R -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -| EIF4EBP1

description_full:
  IGF-IGF1R-PI3K signaling pathway. Pathway ID: N00582. Pathway type: Reference. Pathway class: nt06168 Herpes simplex virus 1 (HSV-1).


description_brief: Pathway Definition from KEGG: IGF -> IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47483
exact_source: N00233
external_details_URL: https://www.kegg.jp/entry/N00233
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  IGF-IGF1R-RAS-ERK signaling pathway. Pathway ID: N00233. Pathway type: Reference. Pathway class: nt06324 GHRH-GH-IGF signaling.


systematic_name: M47634
exact_source: N00852
external_details_URL: https://www.kegg.jp/entry/N00852
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: IB-CoA -- (ACADS,ACAD8,ACADM) >> (ECHS1,HADHA) >> HIBCH >> HIBADH >> ALDH6A1 -> Propanoyl-CoA

description_full:
  Valine degradation. Pathway ID: N00852. Pathway type: Reference. Pathway class: nt06024 Valine, leucine and isoleucine degradation.


systematic_name: M47635
exact_source: N00856
external_details_URL: https://www.kegg.jp/entry/N00856
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: 2-MB-CoA -- (ACADS,ACADSB,ACADM) >> (ECHS1,HADHA) >> (HSD17B10,HADH) >> (ACAA1/2,HADHB) -> Propanoyl-CoA

description_full:
  Isoleucine degradation. Pathway ID: N00856. Pathway type: Reference. Pathway class: nt06024 Valine, leucine and isoleucine degradation.


systematic_name: M47689
exact_source: N01001
external_details_URL: https://www.kegg.jp/entry/N01001
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> mAChR -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS

description_full:
  Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway. Pathway ID: N01001. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47685
exact_source: N00997
external_details_URL: https://www.kegg.jp/entry/N00997
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 == CDK5 -> MAPT -| CxI -> Q

description_full:
  Mutation-caused aberrant Abeta to electron transfer in Complex I. Pathway ID: N00997. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47700
exact_source: N01018
external_details_URL: https://www.kegg.jp/entry/N01018
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> CHRNA7 -> Ca2+ -> CAPN -> CDK5R1 == CDK5 -> MAPT -| (TUBA+TUBB)

description_full:
  Mutation-caused aberrant Abeta to anterograde axonal transport. Pathway ID: N01018. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47684
exact_source: N00996
external_details_URL: https://www.kegg.jp/entry/N00996
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> AGER -> RAS -> RAF -> MEK -> ERK -> NFKB => (TNF,IL6,NOS2)

description_full:
  Mutation-caused aberrant Abeta to AGE-RAGE signaling pathway. Pathway ID: N00996. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: APP* -> Abeta -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS
systematic_name: M47691
exact_source: N01003
external_details_URL: https://www.kegg.jp/entry/N01003
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Abeta to transport of calcium. Pathway ID: N01003. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47690
exact_source: N01002
external_details_URL: https://www.kegg.jp/entry/N01002
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  Mutation-caused aberrant Abeta to mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N01002. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47693
exact_source: N01005
external_details_URL: https://www.kegg.jp/entry/N01005
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> FAS -> FADD -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  Mutation-caused aberrant Abeta to crosstalk between extrinsic and intrinsic apoptotic pathways. Pathway ID: N01005. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: APP* -> Abeta -> MAP3K5 -> MAP2K7 -> JNK
systematic_name: M47698
exact_source: N01014
external_details_URL: https://www.kegg.jp/entry/N01014
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Abeta to IRE1a-JNK signaling pathway. Pathway ID: N01014. Pathway type: Variant. Pathway class: nt06534 Unfolded protein response.


description_brief: Pathway Definition from KEGG: APP* -> Abeta -| CxIV -> H2O
systematic_name: M47687
exact_source: N00999
external_details_URL: https://www.kegg.jp/entry/N00999
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Abeta to electron transfer in Complex IV. Pathway ID: N00999. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: APP* -> Abeta -> PPID -> MPTP -> CYCS
systematic_name: M47694
exact_source: N01006
external_details_URL: https://www.kegg.jp/entry/N01006
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway. Pathway ID: N01006. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: APP* -> Abeta -| 26S
systematic_name: M47713
exact_source: N01060
external_details_URL: https://www.kegg.jp/entry/N01060
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant Abeta to 26S proteasome-mediated protein degradation. Pathway ID: N01060. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47692
exact_source: N01004
external_details_URL: https://www.kegg.jp/entry/N01004
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: APP* -> Abeta -> VGCC(L-type) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS

description_full:
  Mutation-caused aberrant Abeta to VGCC-Ca2+ -apoptotic pathway. Pathway ID: N01004. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: (NICD+RBPJ+TBX6) => MESP2 => (RIPPLY2,LFNG,EPHA4)
systematic_name: M47867
exact_source: N01481
external_details_URL: https://www.kegg.jp/entry/N01481
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Notch-MESP2 signaling. Pathway ID: N01481. Pathway type: Reference. Pathway class: nt06511 NOTCH signaling.


systematic_name: M47470
exact_source: N00186
external_details_URL: https://www.kegg.jp/entry/N00186
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK3/6 -> MAPK14 -> MK2 -| TTP

description_full:
  IL1-IL1R-p38 signaling pathway. Pathway ID: N00186. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


systematic_name: M47471
exact_source: N00188
external_details_URL: https://www.kegg.jp/entry/N00188
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: IL1 -> IL1R -> MYD88 -> IRAK1/4 -> TRAF6 -> TAB1/2/3 -> TAK1 -> MKK4/7 -> JNK -> AP1

description_full:
  IL1-IL1R-JNK signaling pathway. Pathway ID: N00188. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


description_brief: Pathway Definition from KEGG: Cytokine -> Receptor -> JAK -> STAT => PIM1
systematic_name: M47408
exact_source: N00053
external_details_URL: https://www.kegg.jp/entry/N00053
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Cytokine-Jak-STAT signaling pathway. Pathway ID: N00053. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


systematic_name: M47904
exact_source: N01554
external_details_URL: https://www.kegg.jp/entry/N01554
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IL2,IL4,IL7,IL9,IL15,IL21,TSLP) -> ((IL2RG+IL2RB+(IL2RA,IL15RA),(IL2RG+(IL4R,IL7R,IL9R,IL21R),(IL7R+CRLF2)) -> (JAK1+JAK3) -> (STAT1,STAT3,STAT5,STAT6)

description_full:
  IL2 family to Jak-STAT signaling pathway. Pathway ID: N01554. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.


description_brief: Pathway Definition from KEGG: FASLG -> FAS -> (DAXX+ASK1) -> JNK
systematic_name: M47711
exact_source: N01056
external_details_URL: https://www.kegg.jp/entry/N01056
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FAS-JNK signaling pathway. Pathway ID: N01056. Pathway type: Reference. Pathway class: nt06524 Apoptosis.


description_brief: Pathway Definition from KEGG: FASLG -> FAS -> FADD -> (RIPK1+RIPK3)
systematic_name: M48993
exact_source: N01632
external_details_URL: https://www.kegg.jp/entry/N01632
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FASLG-RIPK1/3 signaling pathway. Pathway ID: N01632. Pathway type: Reference. Pathway class: nt06527 Necroptosis.


systematic_name: M47448
exact_source: N00146
external_details_URL: https://www.kegg.jp/entry/N00146
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (FASLG,TNFSF10) -> (FAS,TNFRSF10B) -> FADD -> (CASP8,CASP10) -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

description_full:
  Crosstalk between extrinsic and intrinsic apoptotic pathways. Pathway ID: N00146. Pathway type: Reference. Pathway class: nt06524 Apoptosis.


description_brief: Pathway Definition from KEGG: P12 -> IL2RB/G -> JAK1/3 -> STAT5 => IL2
systematic_name: M47581
exact_source: N00491
external_details_URL: https://www.kegg.jp/entry/N00491
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 p12 to Jak-STAT signaling pathway. Pathway ID: N00491. Pathway type: Pathogen. Pathway class: nt06518 JAK-STAT signaling.


systematic_name: M47906
exact_source: N01556
external_details_URL: https://www.kegg.jp/entry/N01556
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IL6,IL11,IL13,IL27,IL31,OSM,LIF,CNTF,CTF1,CLCF1) -> ((IL6ST+(IL6R,IL11RA,IL27RA,OSMR,LIFR,CNTFR)),(IL4R+IL13RA),(IL31RA+OSMR)) -> (JAK1+JAK2+TYK2) -> (STAT1,STAT3,STAT6)

description_full:
  IL6 family to Jak-STAT signaling pathway. Pathway ID: N01556. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.


description_brief: Pathway Definition from KEGG: CXCL8 -> CXCR2 -> GNB/G -> RAS -> RAF1 -> MEK -> ERK
systematic_name: M47454
exact_source: N00152
external_details_URL: https://www.kegg.jp/entry/N00152
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CXCR-GNB/G-ERK signaling pathway. Pathway ID: N00152. Pathway type: Reference. Pathway class: nt06224 CXCR signaling.


description_brief: Pathway Definition from KEGG: CXCL8 -> CXCR2 -> GNB/G -> PI3Kgamma -> PIP3 -> AKT -> MTOR
systematic_name: M47456
exact_source: N00154
external_details_URL: https://www.kegg.jp/entry/N00154
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CXCR-GNB/G-PI3K-AKT signaling pathway. Pathway ID: N00154. Pathway type: Reference. Pathway class: nt06224 CXCR signaling.


systematic_name: M47556
exact_source: N00415
external_details_URL: https://www.kegg.jp/entry/N00415
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IL10,IL19,IL20,IL22,IL24,IL26) -> ((IL10RB+(IL10RA,IL20RA,IL22RA1)) -> (JAK1+TYK2) -> STAT3

description_full:
  IL10 family to Jak-STAT signaling pathway. Pathway ID: N00415. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.


systematic_name: M47907
exact_source: N01557
external_details_URL: https://www.kegg.jp/entry/N01557
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IL12,IL23A) -> ((IL12RB1+IL12RB2),(IL12RB1+IL23R)) -> (JAK2+TYK2) -> (STAT3,STAT4)

description_full:
  IL12/23 to Jak-STAT signaling pathway. Pathway ID: N01557. Pathway type: Reference. Pathway class: nt06518 JAK-STAT signaling.


description_brief: Pathway Definition from KEGG: INHBA -> ((ACVR2A,ACVR2B)+(ACVR1B,ACVR1C)) -> (SMAD2,SMAD3) == SMAD4
systematic_name: M47846
exact_source: N01456
external_details_URL: https://www.kegg.jp/entry/N01456
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Activin signaling pathway. Pathway ID: N01456. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


systematic_name: M47725
exact_source: N01081
external_details_URL: https://www.kegg.jp/entry/N01081
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (IpaB+IpaC,IpaD) -> (ITGA5+ITGB1) -> (PTK2+PXN) -> (TLN+VCN) -> (ACTB,ACTG1)

description_full:
  Shigella IpaB/C/D to ITGA/B-TALIN/VINCULIN signaling pathway. Pathway ID: N01081. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: UL75 -> (ITGAV+ITGB3) -> SRC -> RAC -| RHOA
systematic_name: M47538
exact_source: N00394
external_details_URL: https://www.kegg.jp/entry/N00394
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCMV gH to ITGA/B-RhoA signaling pathway. Pathway ID: N00394. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: IV-CoA -- (IVD,ACADM) >> MCCC1/2 >> AUH >> (HMGCL,HMGCLL1) -> AcCoA
systematic_name: M47633
exact_source: N00851
external_details_URL: https://www.kegg.jp/entry/N00851
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Leucine degradation. Pathway ID: N00851. Pathway type: Reference. Pathway class: nt06024 Valine, leucine and isoleucine degradation.


description_brief: Pathway Definition from KEGG: AREG -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47501
exact_source: N00284
external_details_URL: https://www.kegg.jp/entry/N00284
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  AREG-EGFR-PI3K signaling pathway. Pathway ID: N00284. Pathway type: Reference. Pathway class: nt06260 Colorectal cancer.


systematic_name: M47510
exact_source: N00303
external_details_URL: https://www.kegg.jp/entry/N00303
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: KCNJ5* -> Na+ -> (CACNA1D,CACNA1H) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone

description_full:
  Mutation-activated KCNJ5 to angiotensin-aldosterone signaling pathway. Pathway ID: N00303. Pathway type: Variant. Pathway class: nt06316 Renin-angiotensin-aldosterone signaling.


systematic_name: M47946
exact_source: N01635
external_details_URL: https://www.kegg.jp/entry/N01635
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Acetyl-CoA -- ACAT >> HMGCS >> HMGCR >> MVK >> PMVK >> MVD >> IDI >> (FDPS,GGPS1) -> Farnesyl-PP

description_full:
  Mevalonate pathway. Pathway ID: N01635. Pathway type: Reference. Pathway class: nt06034 Cholesterol biosynthesis.


description_brief: Pathway Definition from KEGG: KIT* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47365
exact_source: N00003
external_details_URL: https://www.kegg.jp/entry/N00003
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated KIT to RAS-ERK signaling pathway. Pathway ID: N00003. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: KIT* -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47404
exact_source: N00046
external_details_URL: https://www.kegg.jp/entry/N00046
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated KIT to PI3K signaling pathway. Pathway ID: N00046. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: (KRAS*,NRAS*) -> RAF -> MEK -> ERK -> CCND1
systematic_name: M47374
exact_source: N00012
external_details_URL: https://www.kegg.jp/entry/N00012
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated KRAS/NRAS to ERK signaling pathway. Pathway ID: N00012. Pathway type: Variant. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: (KRAS*,NRAS*) -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47391
exact_source: N00032
external_details_URL: https://www.kegg.jp/entry/N00032
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated KRAS/NRAS to PI3K signaling pathway. Pathway ID: N00032. Pathway type: Variant. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: IpaA -> RHOA -> ROCK1/2 -> MLC
systematic_name: M47721
exact_source: N01074
external_details_URL: https://www.kegg.jp/entry/N01074
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Shigella IpaA to ITGA/B-RhoGEF-RhoA signaling pathway. Pathway ID: N01074. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: SopB -> RHOA -> ROCK2 -> MLC
systematic_name: M47739
exact_source: N01130
external_details_URL: https://www.kegg.jp/entry/N01130
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Salmonella SopB to RhoA signaling pathway. Pathway ID: N01130. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: LAMP2 == GORASP2 == LC3-II
systematic_name: M47979
exact_source: N01722
external_details_URL: https://www.kegg.jp/entry/N01722
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagosome and lysosome fusion, tethering factor, GRASP55. Pathway ID: N01722. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: YopH -| (SLP76,LAT,VAV)
systematic_name: M48994
exact_source: N01108
external_details_URL: https://www.kegg.jp/entry/N01108
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Yersinia YopH to TCR-NFAT signaling pathway. Pathway ID: N01108. Pathway type: Pathogen. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: (LHB+CGA) -> LHCGR -> GNAS -> ADCY -> cAMP -> PKA
systematic_name: M47645
exact_source: N00885
external_details_URL: https://www.kegg.jp/entry/N00885
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  LHCGR-GNAS-PKA signaling pathway. Pathway ID: N00885. Pathway type: Reference. Pathway class: nt06323 KISS1-GnRH-LH/FSH-E2 signaling.


description_brief: Pathway Definition from KEGG: (LMO2*+LDB1) == (LYL1+TCF3) =| PTCRA
systematic_name: M48995
exact_source: N00122
external_details_URL: https://www.kegg.jp/entry/N00122
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  LMO2-rearrangement to transcriptional repression. Pathway ID: N00122. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: (LMO2*+LDB1) == (LYL1+TCF3) => HHEX
systematic_name: M48996
exact_source: N00121
external_details_URL: https://www.kegg.jp/entry/N00121
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  LMO2-rearrangement to transcriptional activation. Pathway ID: N00121. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: LMP2A -> (LYN,SYK) -> PI3K
systematic_name: M48997
exact_source: N00266
external_details_URL: https://www.kegg.jp/entry/N00266
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV LMP2A to PI3K signaling pathway. Pathway ID: N00266. Pathway type: Pathogen. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: (S,N) -> (MBL2,COLEC10/11,FCN)
systematic_name: M47785
exact_source: N01316
external_details_URL: https://www.kegg.jp/entry/N01316
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  SARS-CoV-2 S/N to lectin pathway of coagulation cascade. Pathway ID: N01316. Pathway type: Pathogen. Pathway class: nt06171 SARS coronavirus 2 (SARS-CoV-2).


description_brief: Pathway Definition from KEGG: EBNA3C -> MDM2 -| TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
systematic_name: M47491
exact_source: N00263
external_details_URL: https://www.kegg.jp/entry/N00263
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA3C to p53-mediated transcription. Pathway ID: N00263. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: MDM2* -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
systematic_name: M47417
exact_source: N00068
external_details_URL: https://www.kegg.jp/entry/N00068
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified MDM2 to p21-cell cycle G1/S. Pathway ID: N00068. Pathway type: Variant. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: (MEFV+PYCARD) -> CASP1 -> (IL1B,IL18)
systematic_name: M48998
exact_source: N00868
external_details_URL: https://www.kegg.jp/entry/N00868
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Pyrin inflammasome signaling pathway. Pathway ID: N00868. Pathway type: Reference. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: Metals -> ROS -> MAP3K5 -> MKK4/7 -> JNK -> AP1
systematic_name: M47814
exact_source: N01407
external_details_URL: https://www.kegg.jp/entry/N01407
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Metals to JNK signaling pathway. Pathway ID: N01407. Pathway type: Env factor. Pathway class: nt06211 Other MAPK signaling.


description_brief: Pathway Definition from KEGG: MET* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
systematic_name: M47367
exact_source: N00005
external_details_URL: https://www.kegg.jp/entry/N00005
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated MET to RAS-ERK signaling pathway. Pathway ID: N00005. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: E6 -| MFNG -| NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)
systematic_name: M47533
exact_source: N00381
external_details_URL: https://www.kegg.jp/entry/N00381
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HPV E6 to Notch signaling pathway. Pathway ID: N00381. Pathway type: Pathogen. Pathway class: nt06511 NOTCH signaling.


description_brief: Pathway Definition from KEGG: KITLG -> KIT -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47472
exact_source: N00215
external_details_URL: https://www.kegg.jp/entry/N00215
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KITLG-KIT-RAS-ERK signaling pathway. Pathway ID: N00215. Pathway type: Reference. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: KITLG -> KIT -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47403
exact_source: N00045
external_details_URL: https://www.kegg.jp/entry/N00045
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KITLG-KIT-PI3K signaling pathway. Pathway ID: N00045. Pathway type: Reference. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: ATXN3* // (BECN1+PIK3C3+ATG14+PIK3R4+AMBRA1)
systematic_name: M47662
exact_source: N00962
external_details_URL: https://www.kegg.jp/entry/N00962
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated ATXN3 to autophagy-vesicle nucleation. Pathway ID: N00962. Pathway type: Variant. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: MLK -> MKK4/7 -> JNK
systematic_name: M47929
exact_source: N01594
external_details_URL: https://www.kegg.jp/entry/N01594
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  MLK-JNK signaling pathway. Pathway ID: N01594. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


systematic_name: M47440
exact_source: N00120
external_details_URL: https://www.kegg.jp/entry/N00120
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: MLL-ENL => (MEIS1,HOXA9,HOXA10,HOXA11,SIX1,SIX4,EYA1,CDKN2C,HPGD,GRIA3,FUT8)

description_full:
  MLL-ENL fusion to transcriptional activation. Pathway ID: N00120. Pathway type: Variant. Pathway class: nt06240 Transcription.


systematic_name: M47439
exact_source: N00119
external_details_URL: https://www.kegg.jp/entry/N00119
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: MLL-AF4 == ((CDK9,CCNT)+(MLLT1,MLLT3)+DOT1L) => (LMO2,PBX3,RUNX2,SMAD1,KLF3,MEF2C,HOXA9,HOXA10,JMJD1C,HMGA2,KDM6A,SUPT3H,PROM1,FLT3,BMP2K,IGF1R,CDKN1B,CDK14)

description_full:
  MLL-AF4 fusion to transcriptional activation. Pathway ID: N00119. Pathway type: Variant. Pathway class: nt06240 Transcription.


systematic_name: M47832
exact_source: N01439
external_details_URL: https://www.kegg.jp/entry/N01439
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: MRN == ATM == H2AX -> MRN+ATM+MDC1+H2AX == RNF8+HERC2+UBE2V2+UBE2N -> MRN+ATM+RNF8+MDC1+H2AX == L3MBTL2 == RNF168+UBE2V2+UBE2N+HERC2 == PIAS4

description_full:
  Double-strand break signaling. Pathway ID: N01439. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


systematic_name: M47838
exact_source: N01446
external_details_URL: https://www.kegg.jp/entry/N01446
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: MRN == CtIP == BRCA1+BARD1 == UIMC1+ABRAXAS+BABAM1+BRE+BRCC3 -> BLM,WRN+DNA2+MRN == RPA

description_full:
  DNA end resection and RPA loading. Pathway ID: N01446. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


systematic_name: M47827
exact_source: N01432
external_details_URL: https://www.kegg.jp/entry/N01432
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (MSH2+MSH6,MSH3) == (MLH1+PMS2,PMS1,MLH3) == PCNA == RFC -> RPA == EXO1 -> POLD,POLE -> LIG1

description_full:
  Mismatch repair. Pathway ID: N01432. Pathway type: Reference. Pathway class: nt06503 Mismatch repair.


description_brief: Pathway Definition from KEGG: CytC -- CxIV -> H2O
systematic_name: M47686
exact_source: N00998
external_details_URL: https://www.kegg.jp/entry/N00998
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Electron transfer in Complex IV. Pathway ID: N00998. Pathway type: Reference. Pathway class: nt06252 Mitochondrial ROS formation.


systematic_name: M47428
exact_source: N00092
external_details_URL: https://www.kegg.jp/entry/N00092
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (MYC*+MAX) => CKS1B -> (SCF+SKP2) -| CDKN1B -| (CCNE+CDK2) -> RB1 // E2F

description_full:
  Amplified MYC to p27-cell cycle G1/S. Pathway ID: N00092. Pathway type: Variant. Pathway class: nt06267 Small cell lung cancer.


description_brief: Pathway Definition from KEGG: (MYC*+MAX) => (CCND+CDK4/6) -> RB1 // E2F
systematic_name: M47426
exact_source: N00089
external_details_URL: https://www.kegg.jp/entry/N00089
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified MYC to cell cycle G1/S. Pathway ID: N00089. Pathway type: Variant. Pathway class: nt06267 Small cell lung cancer.


description_brief: Pathway Definition from KEGG: MYCN* == MAX => (MDM2,PTK2,TP53,BMI1)
systematic_name: M47444
exact_source: N00131
external_details_URL: https://www.kegg.jp/entry/N00131
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified MYCN to transcriptional activation. Pathway ID: N00131. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: MYCN* == MAX == (SP1+ZBTB17) => (NTRK1,NGFR)
systematic_name: M47445
exact_source: N00132
external_details_URL: https://www.kegg.jp/entry/N00132
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified MYCN to transcriptional repression. Pathway ID: N00132. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: Eae -> Tir -> NCK -> (WASL+WIPF) -> ARP2/3 -> (ACTB,ACTG1)
systematic_name: M47728
exact_source: N01092
external_details_URL: https://www.kegg.jp/entry/N01092
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia Eae/Tir to Actin signaling pathway. Pathway ID: N01092. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: CxI == CxII == CxIII == CxIV == ATPase -> UCP1
systematic_name: M47970
exact_source: N01691
external_details_URL: https://www.kegg.jp/entry/N01691
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  mitochondrial complex - UCP1 in Thermogenesis. Pathway ID: N01691. Pathway type: Reference. Pathway class: nt06529 Thermogenesis.


systematic_name: M47524
exact_source: N00347
external_details_URL: https://www.kegg.jp/entry/N00347
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (ATM,ATR) -> TADA3 -> EP300 -> TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F

description_full:
  p300-p21-Cell cycle G1/S. Pathway ID: N00347. Pathway type: Reference. Pathway class: nt06166 Human papillomavirus (HPV).


description_brief: Pathway Definition from KEGG: (ATM,ATR) -> CHEK1/2 -| CDC25B/C -> (CCNB+CDK1)
systematic_name: M47572
exact_source: N00455
external_details_URL: https://www.kegg.jp/entry/N00455
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CDC25-Cell cycle G2/M. Pathway ID: N00455. Pathway type: Reference. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: (ATM,ATR) -> CHEK1 -> TP53 => CDKN1A -| (CDK1+CCNB)
systematic_name: M47586
exact_source: N00499
external_details_URL: https://www.kegg.jp/entry/N00499
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ATR-p21-Cell cycle G2/M. Pathway ID: N00499. Pathway type: Reference. Pathway class: nt06230 Cell cycle.


systematic_name: M47511
exact_source: N00304
external_details_URL: https://www.kegg.jp/entry/N00304
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: ATP1A1* -> Na+ -> (CACNA1D,CACNA1H) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone

description_full:
  Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway. Pathway ID: N00304. Pathway type: Variant. Pathway class: nt06316 Renin-angiotensin-aldosterone signaling.


description_brief: Pathway Definition from KEGG: Tat -> NFKB => (TNF,IFNA,IFNB1)
systematic_name: M47564
exact_source: N00436
external_details_URL: https://www.kegg.jp/entry/N00436
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIV Tat to TLR2/4-NFKB signaling pathway. Pathway ID: N00436. Pathway type: Pathogen. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: E6 -> (NFX1+PSEN1) -> NOTCH -> (NICD+RBPJ+MAML) => (HES1,HEY1)
systematic_name: M47534
exact_source: N00382
external_details_URL: https://www.kegg.jp/entry/N00382
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HPV E6 to Notch signaling pathway. Pathway ID: N00382. Pathway type: Pathogen. Pathway class: nt06511 NOTCH signaling.


description_brief: Pathway Definition from KEGG: TAX -> NFYB => MHCII
systematic_name: M47588
exact_source: N00508
external_details_URL: https://www.kegg.jp/entry/N00508
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 Tax to NFY-mediated transcription. Pathway ID: N00508. Pathway type: Pathogen. Pathway class: nt06160 Human T-cell leukemia virus 1 (HTLV-1).


description_brief: Pathway Definition from KEGG: NKX3-1* // AKT -| BAD
systematic_name: M48999
exact_source: N00082
external_details_URL: https://www.kegg.jp/entry/N00082
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Loss of NKX3-1 to PI3K signaling pathway. Pathway ID: N00082. Pathway type: Variant. Pathway class: nt06272 Prostate cancer.


description_brief: Pathway Definition from KEGG: NODAL -> ((ACVR2A,ACVR2B)+(ACVR1B,ACVR1C)) -> (SMAD2,SMAD3) == SMAD4
systematic_name: M47849
exact_source: N01459
external_details_URL: https://www.kegg.jp/entry/N01459
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Nodal signaling pathway. Pathway ID: N01459. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: NOTCH -- ADAM17 >> (PSEN+PSENEN+NCSTN+APH1) -> NICD
systematic_name: M47865
exact_source: N01478
external_details_URL: https://www.kegg.jp/entry/N01478
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Notch proteolytic activation. Pathway ID: N01478. Pathway type: Reference. Pathway class: nt06511 NOTCH signaling.


description_brief: Pathway Definition from KEGG: TRK* -> RAS -> RAF -> MEK -> ERK
systematic_name: M47371
exact_source: N00009
external_details_URL: https://www.kegg.jp/entry/N00009
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TRK fusion kinase to RAS-ERK signaling pathway. Pathway ID: N00009. Pathway type: Variant. Pathway class: nt06274 Thyroid cancer.


description_brief: Pathway Definition from KEGG: ATP2B3* -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone
systematic_name: M47512
exact_source: N00305
external_details_URL: https://www.kegg.jp/entry/N00305
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated ATP2B3 to angiotensin-aldosterone signaling pathway. Pathway ID: N00305. Pathway type: Variant. Pathway class: nt06316 Renin-angiotensin-aldosterone signaling.


description_brief: Pathway Definition from KEGG: glycosylase -> APEX == POLB+XRCC1 == PARP,PARG,ADPRS
systematic_name: M47829
exact_source: N01434
external_details_URL: https://www.kegg.jp/entry/N01434
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Base excision and strand cleavage by bifunctional glycosylase. Pathway ID: N01434. Pathway type: Reference. Pathway class: nt06504 Base excision repair.


description_brief: Pathway Definition from KEGG: ORC == CDC6 == CDT1 == MCM -> pre-RC+DDK == CDC45+TICRR+MTBP == CDK
systematic_name: M47857
exact_source: N01468
external_details_URL: https://www.kegg.jp/entry/N01468
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  DNA replication licensing. Pathway ID: N01468. Pathway type: Reference. Pathway class: nt06509 DNA replication.


description_brief: Pathway Definition from KEGG: PAI -| (PLAU,PLAT)
systematic_name: M47883
exact_source: N01524
external_details_URL: https://www.kegg.jp/entry/N01524
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of fibrinolytic system, PAI. Pathway ID: N01524. Pathway type: Reference. Pathway class: nt06514 Coagulation cascade.


description_brief: Pathway Definition from KEGG: PRKN* -> PLCG1 -> IP3 -> ITPR -> Ca2+
systematic_name: M49000
exact_source: N01032
external_details_URL: https://www.kegg.jp/entry/N01032
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PRKN to mGluR1 signaling pathway. Pathway ID: N01032. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: PRKN* // BAX -> CYCS == APAF1 -> CASP9 -> CASP3
systematic_name: M47708
exact_source: N01049
external_details_URL: https://www.kegg.jp/entry/N01049
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PRKN to intrinsic apoptotic pathway. Pathway ID: N01049. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: Pyruvate -- PC -> OA -- MDH1/2 >> PCK1/2 -> PEP
systematic_name: M47938
exact_source: N01605
external_details_URL: https://www.kegg.jp/entry/N01605
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Gluconeogenesis. Pathway ID: N01605. Pathway type: Reference. Pathway class: nt06031 Citrate cycle and pyruvate metabolism.


description_brief: Pathway Definition from KEGG: ((CDON,BOC),GAS1,LRP2) -> (HH+PTCH)
systematic_name: M47893
exact_source: N01538
external_details_URL: https://www.kegg.jp/entry/N01538
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Hedgehog signaling pathway, PTCH coreceptor. Pathway ID: N01538. Pathway type: Reference. Pathway class: nt06501 HH signaling.


systematic_name: M47517
exact_source: N00323
external_details_URL: https://www.kegg.jp/entry/N00323
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (PDE11A*,PDE8B*) // cAMP -> (PRKAR1A+PRKACA) -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol

description_full:
  Mutation-inactivated PDE11A/PDE8B to ACTH-cortisol signaling pathway. Pathway ID: N00323. Pathway type: Variant. Pathway class: nt06310 CRH-ACTH-cortisol signaling.


description_brief: Pathway Definition from KEGG: (SOST+LRP4) -| (FZD+LRP5/6)
systematic_name: M47834
exact_source: N01441
external_details_URL: https://www.kegg.jp/entry/N01441
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Wnt signaling modulation, SOST/LRP4. Pathway ID: N01441. Pathway type: Reference. Pathway class: nt06505 WNT signaling.


systematic_name: M49001
exact_source: N00776
external_details_URL: https://www.kegg.jp/entry/N00776
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Very-long-chain-acyl-CoA(n) -- ACOX1/3 >> HSD17B4 >> (ACAA1,SCP2) -> Very-long-chain-acyl-CoA(n-2)

description_full:
  beta-Oxidation, peroxisome, VLCFA. Pathway ID: N00776. Pathway type: Reference. Pathway class: nt06021 beta-Oxidation in peroxisome.


systematic_name: M47897
exact_source: N01543
external_details_URL: https://www.kegg.jp/entry/N01543
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (TLR7+TLR8+TLR9) -> MYD88 -> (IRAK4+IRAK1) -> TRAF6 -> IRF5 => (IFNA,IFNB1)

description_full:
  TLR7/8/9-IRF5 signaling pathway. Pathway ID: N01543. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: (TLR7,TLR9) -> MYD88 -> (IRAK4+IRAK1) -> IRF7 => (IFNA,IFNB1)
systematic_name: M47617
exact_source: N00690
external_details_URL: https://www.kegg.jp/entry/N00690
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TLR7/9-IRF7 signaling pathway. Pathway ID: N00690. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: PDGF -> PDGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47398
exact_source: N00039
external_details_URL: https://www.kegg.jp/entry/N00039
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PDGF-PDGFR-PI3K signaling pathway. Pathway ID: N00039. Pathway type: Reference. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: PDGF -> PDGFR -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK
systematic_name: M47387
exact_source: N00028
external_details_URL: https://www.kegg.jp/entry/N00028
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PDGF-PDGFR-PLCG-CAMK signaling pathway. Pathway ID: N00028. Pathway type: Reference. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: PDGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47378
exact_source: N00018
external_details_URL: https://www.kegg.jp/entry/N00018
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified PDGFR to RAS-ERK signaling pathway. Pathway ID: N00018. Pathway type: Variant. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: UL55 -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47535
exact_source: N00386
external_details_URL: https://www.kegg.jp/entry/N00386
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCMV gB to PDGFR-RAS-ERK signaling pathway. Pathway ID: N00386. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: PDGFR* -> PI3K -> PIP3 -> AKT -> MTOR
systematic_name: M47399
exact_source: N00040
external_details_URL: https://www.kegg.jp/entry/N00040
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified PDGFR to PI3K signaling pathway. Pathway ID: N00040. Pathway type: Variant. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: PDGFR* -> PLCG -> IP3 -> Ca2+ -> CALM == CAMK
systematic_name: M47388
exact_source: N00029
external_details_URL: https://www.kegg.jp/entry/N00029
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified PDGFR to PLCG-CAMK signaling pathway. Pathway ID: N00029. Pathway type: Variant. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: RASD1* // GNAI // ADCY -> cAMP -> PKA -> CREB -> ACTH
systematic_name: M47519
exact_source: N00325
external_details_URL: https://www.kegg.jp/entry/N00325
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated RASD1 to CRHR-PKA-ACTH signaling pathway. Pathway ID: N00325. Pathway type: Variant. Pathway class: nt06310 CRH-ACTH-cortisol signaling.


description_brief: Pathway Definition from KEGG: PDYN* -> NMDAR -> Ca2+
systematic_name: M47668
exact_source: N00971
external_details_URL: https://www.kegg.jp/entry/N00971
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant PDYN to transport of calcium. Pathway ID: N00971. Pathway type: Variant. Pathway class: nt06462 Spinocerebellar ataxia.


systematic_name: M47864
exact_source: N01477
external_details_URL: https://www.kegg.jp/entry/N01477
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RTEL1+RAP1+TRF2+TIN2+TRF1+POT1+ACD == telomerase -> Shelterin == CTC1+STN1+TEN1

description_full:
  Telomere elongation. Pathway ID: N01477. Pathway type: Reference. Pathway class: nt06510 Telomere length regulation.


description_brief: Pathway Definition from KEGG: Metals -> ROS -| PTP -| SRC -> ABL -> PKD -> IKK -> NFKBIA -> NFKB
systematic_name: M47816
exact_source: N01411
external_details_URL: https://www.kegg.jp/entry/N01411
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Metals to NFKB signaling pathway. Pathway ID: N01411. Pathway type: Env factor. Pathway class: nt06223 TNF signaling.


description_brief: Pathway Definition from KEGG: P4 -> PGR => (CCND1,TNFSF11,WNT4,CXCL12)
systematic_name: M49002
exact_source: N01362
external_details_URL: https://www.kegg.jp/entry/N01362
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Nuclear-initiated progesterone signaling pathway. Pathway ID: N01362. Pathway type: Reference. Pathway class: nt06227 Nuclear receptor signaling.


description_brief: Pathway Definition from KEGG: E5 -| V-ATPase -| EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47531
exact_source: N00367
external_details_URL: https://www.kegg.jp/entry/N00367
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HPV E5 to EGFR-RAS-ERK signaling pathway. Pathway ID: N00367. Pathway type: Pathogen. Pathway class: nt06166 Human papillomavirus (HPV).


systematic_name: M47625
exact_source: N00748
external_details_URL: https://www.kegg.jp/entry/N00748
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: PI+UDP-GlcNAc -- (PIGA+PIGC+PIGH+PIGP+PIGQ+PIGY+DPM2) >> PIGL >> PIGW >> (PIGM+PIGX) >> PIGV >> PIGN >> PIGB >> (PIGO+PIGF) >> (PIGG+PIGF) >> (GPAA1+PIGK+PIGS+PIGT+PIGU) >> PGAP1 >> PGAP5 -> G13046

description_full:
  GPI-anchor biosynthesis. Pathway ID: N00748. Pathway type: Reference. Pathway class: nt06018 GPI-anchor biosynthesis.


systematic_name: M47717
exact_source: N01067
external_details_URL: https://www.kegg.jp/entry/N01067
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: IpgD -> PI(5)P -> PI3K -> PIP3 -> ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)

description_full:
  Shigella IpgD to ARNO-ARF-ACTB_G signaling pathway. Pathway ID: N01067. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


systematic_name: M47738
exact_source: N01129
external_details_URL: https://www.kegg.jp/entry/N01129
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: SopB -> (PIK3CA/B/G/D,PIK3C2B) -> PIP3 -> ARNO -> ARF6 -> ARF1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)

description_full:
  Salmonella SopB to ARNO-ARF-ACTB/G signaling pathway. Pathway ID: N01129. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: Ca2+(cyto) -> PLCD -> IP3 -> ITPR -> Ca2+(cyto)
systematic_name: M47960
exact_source: N01655
external_details_URL: https://www.kegg.jp/entry/N01655
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+-PLCD-ITPR signaling pathway. Pathway ID: N01655. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: PLG -> FBN1 == LTBP1/3/4 // TGFB
systematic_name: M47850
exact_source: N01460
external_details_URL: https://www.kegg.jp/entry/N01460
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Plasmin mediated activation of latent TGF-beta. Pathway ID: N01460. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: PLK1 -> KIF2A == DDA3 == microtubule
systematic_name: M47911
exact_source: N01562
external_details_URL: https://www.kegg.jp/entry/N01562
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Microtubule depolymerization at the minus ends. Pathway ID: N01562. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: PLK1,AURKB,CDK1 -- NCAPD3,NCAPG2,NCAPH2
systematic_name: M47877
exact_source: N01499
external_details_URL: https://www.kegg.jp/entry/N01499
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Modifying of condensin II subunits. Pathway ID: N01499. Pathway type: Reference. Pathway class: nt06512 Chromosome cohesion and segregation.


description_brief: Pathway Definition from KEGG: (PLN,SLN,MLN,ELN,ALN) -| ATP2A
systematic_name: M47955
exact_source: N01646
external_details_URL: https://www.kegg.jp/entry/N01646
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of SERCA. Pathway ID: N01646. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


systematic_name: M47434
exact_source: N00098
external_details_URL: https://www.kegg.jp/entry/N00098
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (PMAIP1,BBC3,BAD,BCL2L11) -| (BCL2,BCL2L1) -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

description_full:
  Intrinsic apoptotic pathway. Pathway ID: N00098. Pathway type: Reference. Pathway class: nt06524 Apoptosis.


description_brief: Pathway Definition from KEGG: POLB == (POLD,POLE) == PCNA == RFC -> PCNA+FEN1 -> PCNA+LIG1
systematic_name: M47831
exact_source: N01436
external_details_URL: https://www.kegg.jp/entry/N01436
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Long patch BER. Pathway ID: N01436. Pathway type: Reference. Pathway class: nt06504 Base excision repair.


description_brief: Pathway Definition from KEGG: POLD+PCNA -> DNA2 == RNaseH2 == FEN1 -> LIG1
systematic_name: M47860
exact_source: N01472
external_details_URL: https://www.kegg.jp/entry/N01472
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Okazaki fragment maturation. Pathway ID: N01472. Pathway type: Reference. Pathway class: nt06509 DNA replication.


systematic_name: M47825
exact_source: N01430
external_details_URL: https://www.kegg.jp/entry/N01430
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (POLR2+UVSSA) == (ERCC6+ERCC8+CRL4) -> (POLR2+UVSSA+ERCC6+ERCC8+CRL4) == (ERCC3+ERCC2) == (GTF2H) == (CAK)

description_full:
  Transcription-coupled NER. Pathway ID: N01430. Pathway type: Reference. Pathway class: nt06502 Nucleotide excision repair.


systematic_name: M47507
exact_source: N00298
external_details_URL: https://www.kegg.jp/entry/N00298
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: ACTH -> (MC2R+MRAP) -> GNAS -> ADCY -> cAMP -> PKA -> (NR5A1,NR4A1,SP1,PBX1,CREB) => CYP11B2* -> Aldosterone

description_full:
  CYP11B1-CYP11B2 fusion to ACTH-cortisol signaling pathway. Pathway ID: N00298. Pathway type: Variant. Pathway class: nt06310 CRH-ACTH-cortisol signaling.


systematic_name: M47506
exact_source: N00297
external_details_URL: https://www.kegg.jp/entry/N00297
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: ACTH -> (MC2R+MRAP) -> GNAS -> ADCY -> cAMP -> PKA -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol

description_full:
  ACTH-cortisol signaling pathway. Pathway ID: N00297. Pathway type: Reference. Pathway class: nt06310 CRH-ACTH-cortisol signaling.


description_brief: Pathway Definition from KEGG: ATR -> CHEK1 -> WEE1 -| (CCNB+CDK1)
systematic_name: M47574
exact_source: N00459
external_details_URL: https://www.kegg.jp/entry/N00459
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  WEE1-Cell cycle G2/M. Pathway ID: N00459. Pathway type: Reference. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: SLX == MUS81+EME1 == GEN1
systematic_name: M47839
exact_source: N01448
external_details_URL: https://www.kegg.jp/entry/N01448
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Double Holliday junction resolution. Pathway ID: N01448. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


description_brief: Pathway Definition from KEGG: AVP -> AVPR2 -> GNAS -> ADCY3/6/9 -> cAMP -> PKA -> AQP2
systematic_name: M47648
exact_source: N00915
external_details_URL: https://www.kegg.jp/entry/N00915
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  AVP-V2R-PKA signaling pathway. Pathway ID: N00915. Pathway type: Reference. Pathway class: nt06326 AVP signaling.


description_brief: Pathway Definition from KEGG: PP2A -| AKT
systematic_name: M47525
exact_source: N00355
external_details_URL: https://www.kegg.jp/entry/N00355
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PP2A-AKT signaling pathway. Pathway ID: N00355. Pathway type: Reference. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: PP2A == Condensin_II -> TOP2A+KIF4A+DNMT3B == Condensin_I
systematic_name: M47876
exact_source: N01497
external_details_URL: https://www.kegg.jp/entry/N01497
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Condensin loading. Pathway ID: N01497. Pathway type: Reference. Pathway class: nt06512 Chromosome cohesion and segregation.


description_brief: Pathway Definition from KEGG: RFWD3 -| RPA,RAD51 == BCDX2+HELQ
systematic_name: M47894
exact_source: N01539
external_details_URL: https://www.kegg.jp/entry/N01539
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  RAD51 -dsDNA destabilization. Pathway ID: N01539. Pathway type: Reference. Pathway class: nt06508 Interstrand crosslink repair.


description_brief: Pathway Definition from KEGG: ARL8B == PLEKHM1 == RAB7 == HOPS
systematic_name: M47776
exact_source: N01300
external_details_URL: https://www.kegg.jp/entry/N01300
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Tethering of late endosomes and lysosomes. Pathway ID: N01300. Pathway type: Reference. Pathway class: nt06125 Membrane trafficking (bacteria).


systematic_name: M47798
exact_source: N01350
external_details_URL: https://www.kegg.jp/entry/N01350
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (NNK,NNN) -> CHRNA9 -> PI3K -> PIP3 -> AKT -> (ESR1/2,AP1) => (CHRNA9,CCND3)

description_full:
  NNK/NNN to PI3K signaling pathway. Pathway ID: N01350. Pathway type: Env factor. Pathway class: nt06214 PI3K signaling.


description_brief: Pathway Definition from KEGG: PRKACA* -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol
systematic_name: M47514
exact_source: N00320
external_details_URL: https://www.kegg.jp/entry/N00320
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated PRKACA to ACTH-cortisol signaling pathway. Pathway ID: N00320. Pathway type: Variant. Pathway class: nt06360 Cushing syndrome.


systematic_name: M47516
exact_source: N00322
external_details_URL: https://www.kegg.jp/entry/N00322
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (PRKAR1A*+PRKACA) -> (NR5A1,NR4A1,SP1,PBX1,CREB) => (STAR,CYP11B1) -> Cortisol

description_full:
  Mutation-inactivated PRKAR1A to ACTH-cortisol signaling pathway. Pathway ID: N00322. Pathway type: Variant. Pathway class: nt06360 Cushing syndrome.


description_brief: Pathway Definition from KEGG: PRKAR -| PKA
systematic_name: M47896
exact_source: N01542
external_details_URL: https://www.kegg.jp/entry/N01542
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PKA holoenzyme. Pathway ID: N01542. Pathway type: Reference. Pathway class: nt06310 CRH-ACTH-cortisol signaling.


description_brief: Pathway Definition from KEGG: HHAT -> HH -- DISP1 >> SCUBE2 -> HH(extracellular)
systematic_name: M47892
exact_source: N01537
external_details_URL: https://www.kegg.jp/entry/N01537
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Hedgehog signaling pathway, HH ligand secretion. Pathway ID: N01537. Pathway type: Reference. Pathway class: nt06501 HH signaling.


description_brief: Pathway Definition from KEGG: CDK5RAP2 == gamma-TuRC+TPX2 == ch-TOG == microtubule
systematic_name: M47898
exact_source: N01544
external_details_URL: https://www.kegg.jp/entry/N01544
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Microtubule nucleation. Pathway ID: N01544. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: US27 -> Ca2+ -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)
systematic_name: M47555
exact_source: N00414
external_details_URL: https://www.kegg.jp/entry/N00414
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCMV US27 to CXCR4-GNB/G-PLCB-PKC signaling pathway. Pathway ID: N00414. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: S -> PKC -> RAF -> MEK -> ERK -> AP1
systematic_name: M47597
exact_source: N00547
external_details_URL: https://www.kegg.jp/entry/N00547
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HBV LHBs to PKC-ERK signaling pathway. Pathway ID: N00547. Pathway type: Pathogen. Pathway class: nt06263 Hepatocellular carcinoma.


systematic_name: M47920
exact_source: N01580
external_details_URL: https://www.kegg.jp/entry/N01580
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: G00157 -- CSGALNACT1/2 >> CHSY1/3,CHPF -> Chondroitin -- CHST3/7 -> Chondroitin_6-sulfate

description_full:
  Chondroitin sulfate biosynthesis. Pathway ID: N01580. Pathway type: Reference. Pathway class: nt06029 Glycosaminoglycan biosynthesis.


description_brief: Pathway Definition from KEGG: HDAC8 -| ESCO1,ESCO2 -- SMC3 -> CDCA5
systematic_name: M49003
exact_source: N01483
external_details_URL: https://www.kegg.jp/entry/N01483
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Cohesin acetylation. Pathway ID: N01483. Pathway type: Reference. Pathway class: nt06512 Chromosome cohesion and segregation.


description_brief: Pathway Definition from KEGG: OspF -| (ERK,p38)
systematic_name: M47766
exact_source: N01283
external_details_URL: https://www.kegg.jp/entry/N01283
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Shigella OspF to TLR2/4-MAPK signaling pathway. Pathway ID: N01283. Pathway type: Pathogen. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: X -> ERK -> AP1 => MMP9
systematic_name: M49004
exact_source: N00545
external_details_URL: https://www.kegg.jp/entry/N00545
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HBV HBx to ERK signaling pathway. Pathway ID: N00545. Pathway type: Pathogen. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: ERK -> RSK
systematic_name: M47936
exact_source: N01601
external_details_URL: https://www.kegg.jp/entry/N01601
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ERK-RSK signaling. Pathway ID: N01601. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


systematic_name: M47729
exact_source: N01094
external_details_URL: https://www.kegg.jp/entry/N01094
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Eae -> Tir -> (IRTKS,IRSp53) -> TccP -> WASL -> ARP2/3 -> (ACTB,ACTG1)

description_full:
  Escherichia Eae/Tir/TccP to Actin signaling pathway. Pathway ID: N01094. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: (Vpr,Tat) -> JNK -> AP1
systematic_name: M47570
exact_source: N00447
external_details_URL: https://www.kegg.jp/entry/N00447
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIV Vpr/Tat to TNF-JNK signaling pathway. Pathway ID: N00447. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: TAX -> (MAPK8,MAPK9,MAPK10) -> JUN => MMP7
systematic_name: M49005
exact_source: N00503
external_details_URL: https://www.kegg.jp/entry/N00503
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 Tax to TNF-JNK signaling pathway. Pathway ID: N00503. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: YopP/J -| (MEK,MKK3/6,MKK4/7)
systematic_name: M47636
exact_source: N00862
external_details_URL: https://www.kegg.jp/entry/N00862
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Yersinia YopP/J to TLR2/4-MAPK signaling pathway. Pathway ID: N00862. Pathway type: Pathogen. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: EIF2AK2 -> EIF2S1 -| EIF2B
systematic_name: M47602
exact_source: N00571
external_details_URL: https://www.kegg.jp/entry/N00571
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PKR-eIF2alpha signaling pathway. Pathway ID: N00571. Pathway type: Reference. Pathway class: nt06170 Influenza A virus (IAV).


description_brief: Pathway Definition from KEGG: PRL -> PRLR -> JAK2 -> STAT5
systematic_name: M49006
exact_source: N00920
external_details_URL: https://www.kegg.jp/entry/N00920
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PRL-JAK-STAT signaling pathway. Pathway ID: N00920. Pathway type: Reference. Pathway class: nt06325 PRL signaling.


systematic_name: M47761
exact_source: N01200
external_details_URL: https://www.kegg.jp/entry/N01200
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: PRNP* -> NMDAR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  Scrapie conformation PrPSc to transport of calcium. Pathway ID: N01200. Pathway type: Variant. Pathway class: nt06465 Prion disease.


description_brief: Pathway Definition from KEGG: PRNP* -> (GSK3B,CK2) -| (KIF5+KLC)
systematic_name: M47763
exact_source: N01202
external_details_URL: https://www.kegg.jp/entry/N01202
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Oligomeric conformation PrPc to anterograde axonal transport. Pathway ID: N01202. Pathway type: Variant. Pathway class: nt06465 Prion disease.


description_brief: Pathway Definition from KEGG: PRNP* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3
systematic_name: M47759
exact_source: N01198
external_details_URL: https://www.kegg.jp/entry/N01198
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Scrapie conformation PrPSc to PERK-ATF4 signaling pathway. Pathway ID: N01198. Pathway type: Variant. Pathway class: nt06534 Unfolded protein response.


description_brief: Pathway Definition from KEGG: PRNP* -| 26S
systematic_name: M47758
exact_source: N01197
external_details_URL: https://www.kegg.jp/entry/N01197
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Scrapie conformation PrPSc to 26S proteasome-mediated protein degradation. Pathway ID: N01197. Pathway type: Variant. Pathway class: nt06465 Prion disease.


systematic_name: M47760
exact_source: N01199
external_details_URL: https://www.kegg.jp/entry/N01199
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: PRNP* -> (RYR,ITPR) -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  Scrapie conformation PrPSc to mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N01199. Pathway type: Variant. Pathway class: nt06465 Prion disease.


description_brief: Pathway Definition from KEGG: PRNP* -| VGCC(N,L-type) -> Ca2+
systematic_name: M47762
exact_source: N01201
external_details_URL: https://www.kegg.jp/entry/N01201
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Scrapie conformation PrPSc to VGCC-Ca2+ -apoptotic pathway. Pathway ID: N01201. Pathway type: Variant. Pathway class: nt06465 Prion disease.


description_brief: Pathway Definition from KEGG: PRNP -> CAV -> FYN -> PI3K -> PRKCD -> NOX2 -> ERK -> CREB => EGR1
systematic_name: M47764
exact_source: N01204
external_details_URL: https://www.kegg.jp/entry/N01204
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PRNP-PI3K-NOX2 signaling pathway. Pathway ID: N01204. Pathway type: Reference. Pathway class: nt06465 Prion disease.


systematic_name: M47663
exact_source: N00963
external_details_URL: https://www.kegg.jp/entry/N00963
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RELN -> VLDLR == DAB1 -> PI3K -> PIP3 -> AKT -| (TSC1+TSC2) -| RHEB -> MTOR -> S6K

description_full:
  RELN-VLDLR-PI3K signaling pathway. Pathway ID: N00963. Pathway type: Reference. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: PSEN1* -> GSK3B -| (KIF5+KLC)
systematic_name: M47699
exact_source: N01017
external_details_URL: https://www.kegg.jp/entry/N01017
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant PSEN1 to anterograde axonal transport. Pathway ID: N01017. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: PSEN1* -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS
systematic_name: M47696
exact_source: N01008
external_details_URL: https://www.kegg.jp/entry/N01008
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant PSEN1 to mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N01008. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


systematic_name: M47695
exact_source: N01007
external_details_URL: https://www.kegg.jp/entry/N01007
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (PSEN1*,PSEN2*) -> RYR3 -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

description_full:
  Mutation-caused aberrant PSEN to mGluR5-Ca2+ -apoptotic pathway. Pathway ID: N01007. Pathway type: Variant. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: PSEN1* -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3
systematic_name: M49007
exact_source: N01010
external_details_URL: https://www.kegg.jp/entry/N01010
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant PSEN1 to PERK-ATF4 signaling pathway. Pathway ID: N01010. Pathway type: Variant. Pathway class: nt06534 Unfolded protein response.


description_brief: Pathway Definition from KEGG: PI(3.5)P2 -> MCOLN1 -> Ca2+(cyto) -> CALM == CN -> TFEB
systematic_name: M47954
exact_source: N01644
external_details_URL: https://www.kegg.jp/entry/N01644
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Lysosomal Ca2+ release. Pathway ID: N01644. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: PTCH1* // SMO -> (SUFU+KIF7) // GLI => (BMP2/4,HHIP,GLI1,PTCH,WNT)
systematic_name: M47372
exact_source: N00010
external_details_URL: https://www.kegg.jp/entry/N00010
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PTCH1 to Hedgehog signaling pathway. Pathway ID: N00010. Pathway type: Variant. Pathway class: nt06269 Basal cell carcinoma.


description_brief: Pathway Definition from KEGG: PTH -> PTH1R -> GNAS -> ADCY -> cAMP -> PKA
systematic_name: M47504
exact_source: N00288
external_details_URL: https://www.kegg.jp/entry/N00288
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PTH-PTH1R-PKA signaling pathway. Pathway ID: N00288. Pathway type: Reference. Pathway class: nt06318 CaSR-PTH signaling.


description_brief: Pathway Definition from KEGG: As -- AS3MT >> GSTO1 -> MMA -| CxIV
systematic_name: M47811
exact_source: N01394
external_details_URL: https://www.kegg.jp/entry/N01394
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Arsenic to electron transfer in complex IV. Pathway ID: N01394. Pathway type: Env factor. Pathway class: nt06252 Mitochondrial ROS formation.


description_brief: Pathway Definition from KEGG: (MIB,NEUR) -> (DLL,JAG)
systematic_name: M47866
exact_source: N01479
external_details_URL: https://www.kegg.jp/entry/N01479
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Notch ligand ubiquitylation. Pathway ID: N01479. Pathway type: Reference. Pathway class: nt06511 NOTCH signaling.


systematic_name: M47853
exact_source: N01464
external_details_URL: https://www.kegg.jp/entry/N01464
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: FANCM+TOPBP1+MHF+FAAP24 -> ATR -> FAcore == FANCL+UBE2T -> FANCD2+FANCI+Ub

description_full:
  Fanconi anemia pathway. Pathway ID: N01464. Pathway type: Reference. Pathway class: nt06508 Interstrand crosslink repair.


description_brief: Pathway Definition from KEGG: Tir -> SHP1/2 -| (TRAF6+TAK1+TAB2)
systematic_name: M49008
exact_source: N00926
external_details_URL: https://www.kegg.jp/entry/N00926
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia Tir to TLR2/4-MAPK signaling pathway. Pathway ID: N00926. Pathway type: Pathogen. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: (PTPN11,SHC,GAB,GRB2) -> SOS
systematic_name: M47930
exact_source: N01595
external_details_URL: https://www.kegg.jp/entry/N01595
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of GF-RTK-RAS-ERK signaling pathway, adaptor proteins. Pathway ID: N01595. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


description_brief: Pathway Definition from KEGG: Glycogen -- (PYG+AGL) >> PGM1/2 -> Glc-6P -- G6PC1/2/3 -> Glc
systematic_name: M47621
exact_source: N00718
external_details_URL: https://www.kegg.jp/entry/N00718
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Glycogen degradation. Pathway ID: N00718. Pathway type: Reference. Pathway class: nt06017 Glycogen metabolism.


description_brief: Pathway Definition from KEGG: (NLRC4+PYCARD) -> CASP1 -> (IL1B,IL18)
systematic_name: M49009
exact_source: N00867
external_details_URL: https://www.kegg.jp/entry/N00867
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  NLRC4 inflammasome signaling pathway. Pathway ID: N00867. Pathway type: Reference. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: TRAPPI -> RAB1
systematic_name: M47771
exact_source: N01291
external_details_URL: https://www.kegg.jp/entry/N01291
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TRAPPI-RAB1 signaling pathway. Pathway ID: N01291. Pathway type: Reference. Pathway class: nt06125 Membrane trafficking (bacteria).


description_brief: Pathway Definition from KEGG: EspT -> RAC1 -> (WASF2+ABI1) -> ARP2/3 -> (ACTB,ACTG1)
systematic_name: M47726
exact_source: N01086
external_details_URL: https://www.kegg.jp/entry/N01086
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia EspT to RAC signaling pathway. Pathway ID: N01086. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


systematic_name: M47737
exact_source: N01128
external_details_URL: https://www.kegg.jp/entry/N01128
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: SopE -> RAC1 -> (WASF+ABI1+HSPC300+CYFIP+NCKAP1) -> ARP2/3 -> (ACTB,ACTG1)

description_full:
  Salmonella SopE to RAC signaling pathway. Pathway ID: N01128. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: (RAC1,CDC42) -> PAK1 -> RAF -> MEK -> ERK
systematic_name: M47735
exact_source: N01119
external_details_URL: https://www.kegg.jp/entry/N01119
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  RAC/CDC42-PAK-ERK signaling pathway. Pathway ID: N01119. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


systematic_name: M47856
exact_source: N01467
external_details_URL: https://www.kegg.jp/entry/N01467
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RAG1+RAG2 -> Ku == DNAPKC -> DNAPK+ARTEMIS -> DNAPK+POLX -> DNAPK == LIG4+XRCC4+XLF

description_full:
  V(D)J recombination. Pathway ID: N01467. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


description_brief: Pathway Definition from KEGG: RasGAP -| RAS
systematic_name: M47935
exact_source: N01600
external_details_URL: https://www.kegg.jp/entry/N01600
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of GF-RTK-RAS-ERK signaling, RasGAP. Pathway ID: N01600. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


description_brief: Pathway Definition from KEGG: E7 -> (RB1,RBL1,RBL2) // E2F
systematic_name: M47528
exact_source: N00361
external_details_URL: https://www.kegg.jp/entry/N00361
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HPV E7 to cell cycle G1/S. Pathway ID: N00361. Pathway type: Pathogen. Pathway class: nt06166 Human papillomavirus (HPV).


systematic_name: M47781
exact_source: N01307
external_details_URL: https://www.kegg.jp/entry/N01307
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: S -| ACE2 -| AngII -> AGTR1 -> NOX2 -> ROS -> NFKB -> (TNF,IL6,IL1B,IL12,MMP3,MMP1,CCL2,CXCL8)

description_full:
  SARS-CoV-2 S to AngII-AT1R-NOX2 signaling pathway. Pathway ID: N01307. Pathway type: Pathogen. Pathway class: nt06171 SARS coronavirus 2 (SARS-CoV-2).


description_brief: Pathway Definition from KEGG: (CCND1*+CDK4) -> RB1 // E2F
systematic_name: M47494
exact_source: N00275
external_details_URL: https://www.kegg.jp/entry/N00275
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified CCND1 to cell cycle G1/S. Pathway ID: N00275. Pathway type: Variant. Pathway class: nt06270 Breast cancer.


description_brief: Pathway Definition from KEGG: EBNA3C -> (CCND+CDK4/6) -> RB1 // E2F
systematic_name: M49010
exact_source: N00483
external_details_URL: https://www.kegg.jp/entry/N00483
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA3C to cell cycle G1/S. Pathway ID: N00483. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: BCL2* -| BAX -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)
systematic_name: M47435
exact_source: N00100
external_details_URL: https://www.kegg.jp/entry/N00100
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  BCL2-overexpression to intrinsic apoptotic pathway. Pathway ID: N00100. Pathway type: Variant. Pathway class: nt06267 Small cell lung cancer.


description_brief: Pathway Definition from KEGG: BARF1 -> BCL2 -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3
systematic_name: M47577
exact_source: N00478
external_details_URL: https://www.kegg.jp/entry/N00478
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV BARF1 to intrinsic apoptotic pathway. Pathway ID: N00478. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: REL* => (CCND2,BCL2A1,BIRC3,TRAF1,BCL2L1,CD86,CD40)
systematic_name: M47441
exact_source: N00123
external_details_URL: https://www.kegg.jp/entry/N00123
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified REL to transcription. Pathway ID: N00123. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: RET* -> PI3K -> PIP3 -> AKT -> MTOR
systematic_name: M47715
exact_source: N01065
external_details_URL: https://www.kegg.jp/entry/N01065
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated RET to PI3K signaling pathway. Pathway ID: N01065. Pathway type: Variant. Pathway class: nt06214 PI3K signaling.


description_brief: Pathway Definition from KEGG: PROK2* -> PROKR1/2 -> GNAI -> ERK
systematic_name: M47642
exact_source: N00880
external_details_URL: https://www.kegg.jp/entry/N00880
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PROK2 to PROK-PRKR-Gi-ERK signaling pathway. Pathway ID: N00880. Pathway type: Variant. Pathway class: nt06361 Hypogonadotropic hypogonadism.


description_brief: Pathway Definition from KEGG: (RORA+KAT5) => (ITPR1,SLC1A6,GRM1)
systematic_name: M49011
exact_source: N00965
external_details_URL: https://www.kegg.jp/entry/N00965
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  RORA-mediated transcription. Pathway ID: N00965. Pathway type: Reference. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: RPA == RAD17+9-1-1 == TOPBP1 == ATR+ATRIP -> CHEK1
systematic_name: M47841
exact_source: N01451
external_details_URL: https://www.kegg.jp/entry/N01451
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ATR signaling. Pathway ID: N01451. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


systematic_name: M47842
exact_source: N01452
external_details_URL: https://www.kegg.jp/entry/N01452
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RPA == BRCA1+BARD1 == BRCA2+PALB2+DSS1 == RAD51 == BCDX2,CX3 -> RAD54 -> PCNA+RFC == POLD,POLE,POLK,POLH

description_full:
  Homologous recombination. Pathway ID: N01452. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


description_brief: Pathway Definition from KEGG: 40S == mRNA == 60S
systematic_name: M47786
exact_source: N01317
external_details_URL: https://www.kegg.jp/entry/N01317
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Translation initiation. Pathway ID: N01317. Pathway type: Reference. Pathway class: nt06171 SARS coronavirus 2 (SARS-CoV-2).


description_brief: Pathway Definition from KEGG: (Protein+UB) -- 26S -> Peptide
systematic_name: M47701
exact_source: N01029
external_details_URL: https://www.kegg.jp/entry/N01029
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  26S proteasome-mediated protein degradation. Pathway ID: N01029. Pathway type: Reference. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: (CLIP1,CLIP2)+(CLASP1,CLASP2) == EB1 == microtubule
systematic_name: M47903
exact_source: N01553
external_details_URL: https://www.kegg.jp/entry/N01553
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Promotion of microtubule growth. Pathway ID: N01553. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: Core -> (RXRA+PPARA) => (CCND1,CDK4,MYC)
systematic_name: M49012
exact_source: N00529
external_details_URL: https://www.kegg.jp/entry/N00529
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HCV core to RXRA/PPARA-mediated transcription. Pathway ID: N00529. Pathway type: Pathogen. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: ATXN1* -| (RORA+KAT5) => (ITPR1,SLC1A6,GRM1)
systematic_name: M47665
exact_source: N00966
external_details_URL: https://www.kegg.jp/entry/N00966
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant ATXN1 to RORA-mediated transcription. Pathway ID: N00966. Pathway type: Variant. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: (CC,CXC) -> (CCR,CXCR) -> GNB/G -> PI3Kgamma -> PREX1 -> RAC1
systematic_name: M47455
exact_source: N00153
external_details_URL: https://www.kegg.jp/entry/N00153
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CCR/CXCR-GNB/G-PI3K-RAC signaling pathway. Pathway ID: N00153. Pathway type: Reference. Pathway class: nt06224 CXCR signaling.


systematic_name: M47547
exact_source: N00406
external_details_URL: https://www.kegg.jp/entry/N00406
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (CCL2,CCL3,CCL4,CCL5,CX3CL1) -> US28 -> GNA12/13 -> (ARHGEF12,ARHGEF1) -> RHOA -> ROCK1/2 -> CTNNB1

description_full:
  HCMV US28 to GNA12/13-Rho signaling pathway. Pathway ID: N00406. Pathway type: Pathogen. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: CCL2 -> CCR2 -> GNB/G -> PI3K -> PIP3 -> AKT -> IKK -> NFKBIA -> NFKB
systematic_name: M47540
exact_source: N00399
external_details_URL: https://www.kegg.jp/entry/N00399
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CCR2-GNB/G-PI3K-NFKB signaling pathway. Pathway ID: N00399. Pathway type: Reference. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: CCL5 -> CCR5 -> GNB/G -> PLCB -> (Ca2+,DAG) -> PKC
systematic_name: M47557
exact_source: N00428
external_details_URL: https://www.kegg.jp/entry/N00428
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CCR5-GNB/G-PLCB/G-PKC signaling pathway. Pathway ID: N00428. Pathway type: Reference. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: CX3CL1 -> CX3CR1 -> GNAI -| ADCY -> cAMP -> PKA
systematic_name: M47544
exact_source: N00403
external_details_URL: https://www.kegg.jp/entry/N00403
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CX3CR1-GNAI-AC-PKA signaling pathway. Pathway ID: N00403. Pathway type: Reference. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNA12/13 -> (ARHGEF12,ARHGEF1) -> RHOA -> ROCK1/2
systematic_name: M47546
exact_source: N00405
external_details_URL: https://www.kegg.jp/entry/N00405
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CXCR4-GNA12/13-Rho signaling pathway. Pathway ID: N00405. Pathway type: Reference. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNAI -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47558
exact_source: N00430
external_details_URL: https://www.kegg.jp/entry/N00430
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CXCR4-GNAI-PI3K-BAD signaling pathway. Pathway ID: N00430. Pathway type: Reference. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


systematic_name: M47596
exact_source: N00546
external_details_URL: https://www.kegg.jp/entry/N00546
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> PKC -> RAF -> MEK -> ERK

description_full:
  CXCL12-CXCR4-PKC-ERK signaling pathaway. Pathway ID: N00546. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


systematic_name: M47542
exact_source: N00401
external_details_URL: https://www.kegg.jp/entry/N00401
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNAQ -> (PLCB,PLCG) -> IP3 -> Ca2+ -> CALM == CN -> NFAT

description_full:
  CXCR4-GNAQ-PLCB/G-calcineurin signaling pathway. Pathway ID: N00401. Pathway type: Reference. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


systematic_name: M47554
exact_source: N00413
external_details_URL: https://www.kegg.jp/entry/N00413
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNB/G -> PLCB -> (Ca2+,DAG) -> PKC -> PTK2B -> (PTK2+BCAR1+CRK+PXN)

description_full:
  CXCR4-GNB/G-PLCB-PKC signaling pathway. Pathway ID: N00413. Pathway type: Reference. Pathway class: nt06167 Human cytomegalovirus (HCMV).


description_brief: Pathway Definition from KEGG: CXCL12 -> CXCR4 -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL
systematic_name: M47561
exact_source: N00433
external_details_URL: https://www.kegg.jp/entry/N00433
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CXCR4-GNB/G-RAC signaling pathway. Pathway ID: N00433. Pathway type: Reference. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: Protein-Ser -- XYLT1/2 >> B4GALT7 >> B3GALT6 >> B3GAT3 -> G00157
systematic_name: M47914
exact_source: N01574
external_details_URL: https://www.kegg.jp/entry/N01574
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Glycosaminoglycan biosynthesis, linkage tetrasaccharide. Pathway ID: N01574. Pathway type: Reference. Pathway class: nt06029 Glycosaminoglycan biosynthesis.


systematic_name: M47782
exact_source: N01308
external_details_URL: https://www.kegg.jp/entry/N01308
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RNA -> MDA5 -> MAVS -> TRAF3 -> (TANK+NAP1+SINTBAD) -> (TBK1+IKBKE) -> (IRF7,IRF3) => (IFNA,IFNB1)

description_full:
  MDA5-IRF7/3 signaling pathway. Pathway ID: N01308. Pathway type: Reference. Pathway class: nt06519 RLR signaling.


description_brief: Pathway Definition from KEGG: (SFRP,WIF1,CER1,NOTUM,TRABD2) -| WNT
systematic_name: M47835
exact_source: N01442
external_details_URL: https://www.kegg.jp/entry/N01442
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Wnt signaling modulation, Wnt inhibitor. Pathway ID: N01442. Pathway type: Reference. Pathway class: nt06505 WNT signaling.


description_brief: Pathway Definition from KEGG: TAX -> (ANAPC+CDC20) -| PTTG -| ESPL1
systematic_name: M47476
exact_source: N00221
external_details_URL: https://www.kegg.jp/entry/N00221
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 Tax to spindle assembly checkpoint signaling. Pathway ID: N00221. Pathway type: Pathogen. Pathway class: nt06230 Cell cycle.


description_brief: Pathway Definition from KEGG: ANAPC+CDC20 -| PTTG1 -| ESPL1 -| RAD21
systematic_name: M47871
exact_source: N01486
external_details_URL: https://www.kegg.jp/entry/N01486
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Cohesin dissociation in anaphase. Pathway ID: N01486. Pathway type: Reference. Pathway class: nt06512 Chromosome cohesion and segregation.


systematic_name: M47414
exact_source: N00062
external_details_URL: https://www.kegg.jp/entry/N00062
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: HH -> PTCH // SMO -> (SMO+EVC) -> (SUFU+KIF7) // GLI => (GLI1,PTCH,HHIP)

description_full:
  Hedgehog signaling pathway. Pathway ID: N00062. Pathway type: Reference. Pathway class: nt06501 HH signaling.


description_brief: Pathway Definition from KEGG: PORCN -> WNT
systematic_name: M47836
exact_source: N01443
external_details_URL: https://www.kegg.jp/entry/N01443
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Wnt signaling modulation, Wnt acylation. Pathway ID: N01443. Pathway type: Reference. Pathway class: nt06505 WNT signaling.


systematic_name: M47843
exact_source: N01453
external_details_URL: https://www.kegg.jp/entry/N01453
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: BMP -> ((ACVR2A,ACVR2B,BMPR2)+(BMPR1A,BMPR1B,ACVR1)) -> (SMAD1,SMAD5,SMAD9) == SMAD4

description_full:
  BMP signaling pathway. Pathway ID: N01453. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


systematic_name: M47848
exact_source: N01458
external_details_URL: https://www.kegg.jp/entry/N01458
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: BMP2/6 -> ((ACVR2B,BMPR2)+(ACVR1,BMPR1A) -> (SMAD1,SMAD5,SMAD9) == SMAD4 => HAMP

description_full:
  BMP-HAMP signaling pathway. Pathway ID: N01458. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: (SCF+SKP2) -| CDKN1B -| ((CCNA,CCNE)+CDK2) -> RB1 // E2F
systematic_name: M47427
exact_source: N00091
external_details_URL: https://www.kegg.jp/entry/N00091
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  p27-Cell cycle G1/S. Pathway ID: N00091. Pathway type: Reference. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: PINK1* // (HTRA2,TRAP1) // CYCS == APAF1 -> CASP9 -> CASP3
systematic_name: M47707
exact_source: N01048
external_details_URL: https://www.kegg.jp/entry/N01048
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PINK1 to intrinsic apoptotic pathway. Pathway ID: N01048. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: PINK1* -| CxI -> Q
systematic_name: M47706
exact_source: N01043
external_details_URL: https://www.kegg.jp/entry/N01043
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PINK1 to electron transfer in Complex I. Pathway ID: N01043. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) // OPTN*
systematic_name: M47743
exact_source: N01138
external_details_URL: https://www.kegg.jp/entry/N01138
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated OPTN to PINK-Parkin-mediated autophagosome formation. Pathway ID: N01138. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


systematic_name: M47742
exact_source: N01137
external_details_URL: https://www.kegg.jp/entry/N01137
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) == (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3

description_full:
  PINK-Parkin-mediated autophagosome formation. Pathway ID: N01137. Pathway type: Reference. Pathway class: nt06464 Amyotrophic lateral sclerosis.


systematic_name: M47744
exact_source: N01139
external_details_URL: https://www.kegg.jp/entry/N01139
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: PINK1 -> PRKN -> (CISD1,CISD2,FAF2,FKBP8,TOMM70,HK1) // SQSTM1* // LC3

description_full:
  Mutation-inactivated p62 to PINK-Parkin-mediated autophagosome formation. Pathway ID: N01139. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: PINK1* // PRKN // BAX -> CYCS == APAF1 -> CASP9 -> CASP3
systematic_name: M47709
exact_source: N01050
external_details_URL: https://www.kegg.jp/entry/N01050
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PINK1 to intrinsic apoptotic pathway. Pathway ID: N01050. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: EBNA3C -> SKP2 -| CDKN1B -| ((CCNA,CCNE)+CDK2) -> RB1 // E2F
systematic_name: M47492
exact_source: N00264
external_details_URL: https://www.kegg.jp/entry/N00264
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA3C to p27-Cell cycle G1/S. Pathway ID: N00264. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: EBNA3C -> SKP2 -> RB1 // E2F
systematic_name: M49013
exact_source: N00484
external_details_URL: https://www.kegg.jp/entry/N00484
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA3C to cell cycle G1/S. Pathway ID: N00484. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: SMO* -> (SUFU+KIF7) // GLI => (BMP2/4,HHIP,GLI1,PTCH,WNT)
systematic_name: M47377
exact_source: N00017
external_details_URL: https://www.kegg.jp/entry/N00017
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated SMO to Hedgehog signaling pathway. Pathway ID: N00017. Pathway type: Variant. Pathway class: nt06269 Basal cell carcinoma.


description_brief: Pathway Definition from KEGG: Sphingomyelin -- SMPD -> Ceramide -- ASAH -> Sphingosine
systematic_name: M47611
exact_source: N00649
external_details_URL: https://www.kegg.jp/entry/N00649
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Hydrolysis of sphingomyelin. Pathway ID: N00649. Pathway type: Reference. Pathway class: nt06014 Sphingolipid degradation.


description_brief: Pathway Definition from KEGG: SNCA* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3
systematic_name: M47704
exact_source: N01035
external_details_URL: https://www.kegg.jp/entry/N01035
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SNCA to PERK-ATF4 signaling pathway. Pathway ID: N01035. Pathway type: Variant. Pathway class: nt06534 Unfolded protein response.


description_brief: Pathway Definition from KEGG: SNCA* -| (KIF5+KLC) // (TUBA+TUBB)
systematic_name: M47710
exact_source: N01055
external_details_URL: https://www.kegg.jp/entry/N01055
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SNCA to anterograde axonal transport. Pathway ID: N01055. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: SNCA* -| CxI -> Q
systematic_name: M47705
exact_source: N01042
external_details_URL: https://www.kegg.jp/entry/N01042
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SNCA to electron transfer in Complex I. Pathway ID: N01042. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: SNCA* -| 26S
systematic_name: M47702
exact_source: N01030
external_details_URL: https://www.kegg.jp/entry/N01030
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SNCA to 26S proteasome-mediated protein degradation. Pathway ID: N01030. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


systematic_name: M47703
exact_source: N01031
external_details_URL: https://www.kegg.jp/entry/N01031
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Ca2+(extracellular) -- SNCA* -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  Mutation-caused aberrant SNCA to VGCC-Ca2+ -apoptotic pathway. Pathway ID: N01031. Pathway type: Variant. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: SOD1* -| (DCTN+DNAH+DNAI+DNALI1+DNAL)
systematic_name: M47755
exact_source: N01160
external_details_URL: https://www.kegg.jp/entry/N01160
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SOD1 to retrograde axonal transport. Pathway ID: N01160. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: SOD1* -| BIP -| EIF2AK3 -> EIF2S1 -> ATF4 => DDIT3
systematic_name: M47750
exact_source: N01149
external_details_URL: https://www.kegg.jp/entry/N01149
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SOD1 to PERK-ATF4 signaling pathway. Pathway ID: N01149. Pathway type: Variant. Pathway class: nt06534 Unfolded protein response.


description_brief: Pathway Definition from KEGG: SOD1* -| BCL2 -| (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3
systematic_name: M47740
exact_source: N01135
external_details_URL: https://www.kegg.jp/entry/N01135
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SOD1 to intrinsic apoptotic pathway. Pathway ID: N01135. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: SOD1* -| DERL1 -> (Protein+UB) -- 26S -> Peptide
systematic_name: M47747
exact_source: N01144
external_details_URL: https://www.kegg.jp/entry/N01144
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SOD1 to 26S proteasome-mediated protein degradation. Pathway ID: N01144. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: SPTBN2* -| GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+
systematic_name: M47661
exact_source: N00960
external_details_URL: https://www.kegg.jp/entry/N00960
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-caused aberrant SPTBN2 to mGluR1-TRPC3 signaling pathway. Pathway ID: N00960. Pathway type: Variant. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: IpaC -> SRC -> CTTN -> ARP2/3 -> (ACTB,ACTG1)
systematic_name: M47723
exact_source: N01079
external_details_URL: https://www.kegg.jp/entry/N01079
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Shigella IpaC to Actin signaling pathway. Pathway ID: N01079. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: EspJ -| SRC -> FCGR
systematic_name: M49014
exact_source: N01091
external_details_URL: https://www.kegg.jp/entry/N01091
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia EspJ to IGG-FCGR-RAC signaling pathway. Pathway ID: N01091. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: X -> SRC -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> ELK1
systematic_name: M47593
exact_source: N00540
external_details_URL: https://www.kegg.jp/entry/N00540
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HBV HBx to RAS-ERK signaling pathway. Pathway ID: N00540. Pathway type: Pathogen. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: TAX -> SRF => (FOS,FOSL1,EGR1,EGR2)
systematic_name: M49015
exact_source: N00509
external_details_URL: https://www.kegg.jp/entry/N00509
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 Tax to SRF-mediated transcription. Pathway ID: N00509. Pathway type: Pathogen. Pathway class: nt06160 Human T-cell leukemia virus 1 (HTLV-1).


description_brief: Pathway Definition from KEGG: BRAF* -> MEK -> ERK
systematic_name: M49016
exact_source: N00013
external_details_URL: https://www.kegg.jp/entry/N00013
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated BRAF to ERK signaling pathway. Pathway ID: N00013. Pathway type: Variant. Pathway class: nt06268 Melanoma.


description_brief: Pathway Definition from KEGG: Ca2+(er/sr) -| STIM -> ORAI -> Ca2+(cyto)
systematic_name: M49017
exact_source: N01643
external_details_URL: https://www.kegg.jp/entry/N01643
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+ entry, Store-operated Ca2+ channel. Pathway ID: N01643. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


systematic_name: M47900
exact_source: N01547
external_details_URL: https://www.kegg.jp/entry/N01547
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: AURKA -- (TACC3+ch-TOG) -> (TACC3+ch-TOG) == microtubule -> clathrin == (TACC3+ch-TOG) == microtubule

description_full:
  Kinetochore fiber organization. Pathway ID: N01547. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: (AURKA,AURKB) -| (MCAK+KIF18B) == EB1,EB3 == microtubule
systematic_name: M47910
exact_source: N01561
external_details_URL: https://www.kegg.jp/entry/N01561
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Microtubule depolymerization. Pathway ID: N01561. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: (AURKA,AURKB) -| PP1 -- CENPE+(SKAP+Astrin) == NDC80C
systematic_name: M47887
exact_source: N01531
external_details_URL: https://www.kegg.jp/entry/N01531
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CENPE interaction with NDC80 complex. Pathway ID: N01531. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: TAP1/2 == TAPBP == (PDIA3+CALR) -> (MHCI+B2M)
systematic_name: M47529
exact_source: N00363
external_details_URL: https://www.kegg.jp/entry/N00363
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Antigen processing and presentation by MHC class I molecules. Pathway ID: N00363. Pathway type: Reference. Pathway class: nt06229 MHC presentation.


description_brief: Pathway Definition from KEGG: Tyr -- TAT >> HPD >> HGD >> GSTZ1 >> FAH -> Fumarate+Acetoacetate
systematic_name: M47619
exact_source: N00708
external_details_URL: https://www.kegg.jp/entry/N00708
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Tyrosine degradation. Pathway ID: N00708. Pathway type: Reference. Pathway class: nt06016 Phenylalanine and tyrosine metabolism.


description_brief: Pathway Definition from KEGG: TAX -| E47 => (POLB,LCK,BAX,CDKN2C)
systematic_name: M49018
exact_source: N00511
external_details_URL: https://www.kegg.jp/entry/N00511
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 Tax to E47-mediated transcription. Pathway ID: N00511. Pathway type: Pathogen. Pathway class: nt06160 Human T-cell leukemia virus 1 (HTLV-1).


description_brief: Pathway Definition from KEGG: BUB1+CENPF == RZZ == (NDE1+NDEL1+LIS1),SPDL1,Dynactin == Dynein
systematic_name: M47889
exact_source: N01534
external_details_URL: https://www.kegg.jp/entry/N01534
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Dynein recruitment to the kinetochore. Pathway ID: N01534. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


systematic_name: M47980
exact_source: N01723
external_details_URL: https://www.kegg.jp/entry/N01723
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Trp -- (TDO2,IDO1/2) >> AFMID -> Kyn -- KMO >> KYNU >> HAAO >> QPRT >> NMNAT >> NADSYN1 -> NAD+

description_full:
  NAD biosynthesis. Pathway ID: N01723. Pathway type: Reference. Pathway class: nt06036 Lysine degradation.


systematic_name: M47863
exact_source: N01476
external_details_URL: https://www.kegg.jp/entry/N01476
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TERC+TERT+Pontin+Reptin == DKC1+NOP10+NHP2+GAR1+NAF1 -> TERC+TERT+Pontin+Reptin+Dyskerins == WRAP53+TriC

description_full:
  Assembly and trafficking of telomerase. Pathway ID: N01476. Pathway type: Reference. Pathway class: nt06510 Telomere length regulation.


description_brief: Pathway Definition from KEGG: TERC+TGS1 -> TERC+PAPD5 -> TERC+PARN+ZCCHC8
systematic_name: M49019
exact_source: N01475
external_details_URL: https://www.kegg.jp/entry/N01475
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Telomerase RNA maturation. Pathway ID: N01475. Pathway type: Reference. Pathway class: nt06510 Telomere length regulation.


description_brief: Pathway Definition from KEGG: TGFA* -> EGFR -> PI3K -> PIP3 -> AKT
systematic_name: M47482
exact_source: N00232
external_details_URL: https://www.kegg.jp/entry/N00232
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TGFA-overexpression to PI3K signaling pathway. Pathway ID: N00232. Pathway type: Variant. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: TGFA -> EGFR -> PI3K -> PIP3 -> AKT -> MTOR
systematic_name: M47481
exact_source: N00231
external_details_URL: https://www.kegg.jp/entry/N00231
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TGFA-EGFR-PI3K signaling pathway. Pathway ID: N00231. Pathway type: Reference. Pathway class: nt06260 Colorectal cancer.


systematic_name: M47563
exact_source: N00435
external_details_URL: https://www.kegg.jp/entry/N00435
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (TLR1,TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B)

description_full:
  TLR1/2/4-NFKB signaling pathway. Pathway ID: N00435. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


systematic_name: M47565
exact_source: N00438
external_details_URL: https://www.kegg.jp/entry/N00438
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (TLR2,TLR4) -> (TIRAP+MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> (MEK,MKK3/6,MKK4/7) -> (ERK,p38,JNK) -> AP1

description_full:
  TLR2/4-MAPK signaling pathway. Pathway ID: N00438. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


systematic_name: M47451
exact_source: N00149
external_details_URL: https://www.kegg.jp/entry/N00149
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF3 -> (CREBBP,EP300) => IFNB1

description_full:
  TLR3-IRF3 signaling pathway. Pathway ID: N00149. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: TLR3 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> IRF7 => IFNA
systematic_name: M47450
exact_source: N00148
external_details_URL: https://www.kegg.jp/entry/N00148
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TLR3-IRF7 signaling pathway. Pathway ID: N00148. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: TLR3 -> TICAM1 -> TRAF6 -> TAK1 -> IKK -> NFKBIA -> NFKB
systematic_name: M47601
exact_source: N00563
external_details_URL: https://www.kegg.jp/entry/N00563
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TLR3-NFKB signaling pathway. Pathway ID: N00563. Pathway type: Reference. Pathway class: nt06168 Herpes simplex virus 1 (HSV-1).


systematic_name: M47598
exact_source: N00553
external_details_URL: https://www.kegg.jp/entry/N00553
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TLR4 -> TICAM2 -> TICAM1 -> TRAF3 -> (IKBKE+TBK1) -> (IRF3,IRF7) => IFNB1

description_full:
  TLR4-IRF3/7 signaling pathway. Pathway ID: N00553. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: SERPING1 -| (F11a,F12a,Kallikrein,Plasmin,PLAU,C1R,C1S,MASP1/2)
systematic_name: M47882
exact_source: N01520
external_details_URL: https://www.kegg.jp/entry/N01520
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of fibrinolytic system, C1INH. Pathway ID: N01520. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


systematic_name: M47912
exact_source: N01566
external_details_URL: https://www.kegg.jp/entry/N01566
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TLR5 -> (MYD88) -> (IRAK4+IRAK1) -> (TRAF6+TAK1+TAB2) -> IKK -> NFKBIA -> NFKB => (TNF,IL6,IL12A,IL12B)

description_full:
  TLR5-NFKB signaling pathway. Pathway ID: N01566. Pathway type: Reference. Pathway class: nt06517 TLR signaling.


description_brief: Pathway Definition from KEGG: TNF -> TNFRSF1A -> (TRAF2/5+TRADD+RIPK1+RIPK3)
systematic_name: M47944
exact_source: N01621
external_details_URL: https://www.kegg.jp/entry/N01621
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TNF-RIPK1/3 signaling pathway. Pathway ID: N01621. Pathway type: Reference. Pathway class: nt06527 Necroptosis.


systematic_name: M47453
exact_source: N00151
external_details_URL: https://www.kegg.jp/entry/N00151
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB

description_full:
  TNF-NFKB signaling pathway. Pathway ID: N00151. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


systematic_name: M47568
exact_source: N00444
external_details_URL: https://www.kegg.jp/entry/N00444
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK3/6 -> MAPK14 -> MSK1/2 -> CREB

description_full:
  TNF-p38 signaling pathway. Pathway ID: N00444. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


systematic_name: M47569
exact_source: N00446
external_details_URL: https://www.kegg.jp/entry/N00446
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAK1+TAB1/2) -> MKK4/7 -> JNK -> AP1

description_full:
  TNF-JNK signaling pathway. Pathway ID: N00446. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


systematic_name: M47447
exact_source: N00145
external_details_URL: https://www.kegg.jp/entry/N00145
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TNF -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> FADD -> CASP8 -> (CASP3,CASP7)

description_full:
  Extrinsic apoptotic pathway. Pathway ID: N00145. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


systematic_name: M47566
exact_source: N00441
external_details_URL: https://www.kegg.jp/entry/N00441
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Env -> TNFRSF1A -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB

description_full:
  HIV gp120 to TNF-NFKB signaling pathway. Pathway ID: N00441. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: TAX -| TP53 => CDKN1A -| (CDK2+CCNE) -> RB1 // E2F
systematic_name: M47584
exact_source: N00497
external_details_URL: https://www.kegg.jp/entry/N00497
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HTLV-1 Tax to p21-cell cycle G1/S. Pathway ID: N00497. Pathway type: Pathogen. Pathway class: nt06160 Human T-cell leukemia virus 1 (HTLV-1).


systematic_name: M47837
exact_source: N01445
external_details_URL: https://www.kegg.jp/entry/N01445
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TP53BP1+RIF1+PAXIP1 -> Ku == DNAPKC -> DNAPK+ARTEMIS -> DNAPK+POLX -> DNAPK == LIG4+XRCC4+XLF

description_full:
  Non-homologous end-joining. Pathway ID: N01445. Pathway type: Reference. Pathway class: nt06506 Double-strand break repair.


description_brief: Pathway Definition from KEGG: Trp -- TPH1/2 >> DDC -> Serotonin -- MAO -> 5-HIAL
systematic_name: M47902
exact_source: N01551
external_details_URL: https://www.kegg.jp/entry/N01551
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Serotonin metabolism. Pathway ID: N01551. Pathway type: Reference. Pathway class: nt06028 Dopamine and serotonin metabolism.


description_brief: Pathway Definition from KEGG: vFLIP -> TRAF2 -> IKK -> NFKBIA -> NFKB
systematic_name: M47464
exact_source: N00174
external_details_URL: https://www.kegg.jp/entry/N00174
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV vFLIP to TNF-NFKB signaling pathway. Pathway ID: N00174. Pathway type: Pathogen. Pathway class: nt06223 TNF signaling.


description_brief: Pathway Definition from KEGG: K15 -> TRAF2 -> TAK1 -> IKK -> NFKBIA -> NFKB
systematic_name: M47463
exact_source: N00173
external_details_URL: https://www.kegg.jp/entry/N00173
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV K15 to TNF-NFKB signaling pathway. Pathway ID: N00173. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: LMP1 -> (TRAF3,TRAF5) -> PI3K
systematic_name: M49020
exact_source: N00485
external_details_URL: https://www.kegg.jp/entry/N00485
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV LMP1 to PI3K signaling pathway. Pathway ID: N00485. Pathway type: Pathogen. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: [C4,C2] -- ((MBL2,COLEC10/11,FCN)+MASP1/2) -> [C4b,C2a] -> (C4b+C2a)
systematic_name: M47874
exact_source: N01491
external_details_URL: https://www.kegg.jp/entry/N01491
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Lectin pathway of complement cascade, C4/C2 to C3 convertase formation. Pathway ID: N01491. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


description_brief: Pathway Definition from KEGG: [C4,C2] -- ((C1QA,C1QB,C1QC)+C1R+C1S) -> [C4b,C2a] -> (C4b+C2a)
systematic_name: M47872
exact_source: N01487
external_details_URL: https://www.kegg.jp/entry/N01487
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Classical pathway of complement cascade, C4/C2 to C3 convertase formation. Pathway ID: N01487. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


description_brief: Pathway Definition from KEGG: TRH -> TRHR -> GNAQ/11 -> PLCB -> (Ca2+,DAG) -> PKC -> TSHB
systematic_name: M47649
exact_source: N00918
external_details_URL: https://www.kegg.jp/entry/N00918
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TRH-TRHR-PLCB-PKC signaling pathway. Pathway ID: N00918. Pathway type: Reference. Pathway class: nt06322 TRH-TSH-TH signaling.


description_brief: Pathway Definition from KEGG: (TSC1+TSC2+TBC1D7) -| RHEB -> mTORC1
systematic_name: M47915
exact_source: N01575
external_details_URL: https://www.kegg.jp/entry/N01575
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TSC1/2-mTORC1 signaling pathway. Pathway ID: N01575. Pathway type: Reference. Pathway class: nt06522 mTOR signaling.


systematic_name: M47628
exact_source: N00793
external_details_URL: https://www.kegg.jp/entry/N00793
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TSHB -> TSHR -> GNAQ -> PLCB -> (Ca2+,DAG) -> PKC -> DUOX2 -> H2O2 -> TG

description_full:
  TSH-DUOX2-TG signaling pathway. Pathway ID: N00793. Pathway type: Reference. Pathway class: nt06322 TRH-TSH-TH signaling.


systematic_name: M47627
exact_source: N00782
external_details_URL: https://www.kegg.jp/entry/N00782
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: TSHB -> TSHR -> GNAS -> ADCY -> cAMP -> PKA -> (TTF1,TTF2,PAX8,CREB) => TG

description_full:
  TSH-TG signaling pathway. Pathway ID: N00782. Pathway type: Reference. Pathway class: nt06322 TRH-TSH-TH signaling.


description_brief: Pathway Definition from KEGG: C5 -- ((C4b+C2a+C3b),(C3b+Bb+C3b)) -> C5b -> (C5b+C6+C7+C8+C9)
systematic_name: M47873
exact_source: N01490
external_details_URL: https://www.kegg.jp/entry/N01490
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Common pathway of complement cascade, MAC formation. Pathway ID: N01490. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


description_brief: Pathway Definition from KEGG: PQ -> ROS -| TRX1 -| ASK1 -> JNK
systematic_name: M49021
exact_source: N01417
external_details_URL: https://www.kegg.jp/entry/N01417
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Paraquat to FAS-JNK signaling pathway. Pathway ID: N01417. Pathway type: Env factor. Pathway class: nt06463 Parkinson disease.


systematic_name: M47975
exact_source: N01716
external_details_URL: https://www.kegg.jp/entry/N01716
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Ubiquitinated_protein == (SQSTM1,NBR1,OPTN,CALCOCO2,TAX1BP1,WDFY3) == LC3-II

description_full:
  Autophagy-vesicle nucleation/elongation/maturation, sequestosome-1-like receptor. Pathway ID: N01716. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: OspG -| (UBE2D2+(RBX1+CUL1+SKP1)+FBXW1/11) -> NFKBIA
systematic_name: M47653
exact_source: N00942
external_details_URL: https://www.kegg.jp/entry/N00942
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Shigella OspG to TNF-NFKB signaling pathway. Pathway ID: N00942. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: Glc-1P -- UGP2 >> (GYG1/2+GYS1/2) >> GBE1 -> Glycogen
systematic_name: M47620
exact_source: N00713
external_details_URL: https://www.kegg.jp/entry/N00713
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Glycogen biosynthesis. Pathway ID: N00713. Pathway type: Reference. Pathway class: nt06017 Glycogen metabolism.


description_brief: Pathway Definition from KEGG: glycosylase -> APEX == POLB
systematic_name: M47828
exact_source: N01433
external_details_URL: https://www.kegg.jp/entry/N01433
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Base excision and strand cleavage by monofunctional glycosylase. Pathway ID: N01433. Pathway type: Reference. Pathway class: nt06504 Base excision repair.


description_brief: Pathway Definition from KEGG: VCP* -| (Protein+UB) -- 26S -> Peptide
systematic_name: M47748
exact_source: N01145
external_details_URL: https://www.kegg.jp/entry/N01145
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated VCP to 26S proteasome-mediated protein degradation. Pathway ID: N01145. Pathway type: Variant. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: FimA -> VDAC1 == HK -| BAX
systematic_name: M47654
exact_source: N00950
external_details_URL: https://www.kegg.jp/entry/N00950
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Shigella FimA to crosstalk between extrinsic and intrinsic apoptotic pathways. Pathway ID: N00950. Pathway type: Pathogen. Pathway class: nt06524 Apoptosis.


description_brief: Pathway Definition from KEGG: Vpr -> WEE1 -| (CCNB+CDK1)
systematic_name: M49022
exact_source: N00460
external_details_URL: https://www.kegg.jp/entry/N00460
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIV Vpr to WEE1-cell cycle G2M. Pathway ID: N00460. Pathway type: Pathogen. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: IGH-MMSET -> H3 => CCND2
systematic_name: M47442
exact_source: N00125
external_details_URL: https://www.kegg.jp/entry/N00125
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  IGH-MMSET fusion to transcriptional activation. Pathway ID: N00125. Pathway type: Variant. Pathway class: nt06240 Transcription.


systematic_name: M47412
exact_source: N00060
external_details_URL: https://www.kegg.jp/entry/N00060
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: WNT -> (FZD+LRP6*) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)

description_full:
  LRP6-overexpression to Wnt signaling pathway. Pathway ID: N00060. Pathway type: Variant. Pathway class: nt06270 Breast cancer.


systematic_name: M47409
exact_source: N00056
external_details_URL: https://www.kegg.jp/entry/N00056
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: WNT -> (FZD+LRP5/6) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)

description_full:
  Wnt signaling pathway. Pathway ID: N00056. Pathway type: Reference. Pathway class: nt06505 WNT signaling.


systematic_name: M47411
exact_source: N00059
external_details_URL: https://www.kegg.jp/entry/N00059
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: WNT -> (FZD7*+LRP5/6) -> (DVL+FRAT) -| (GSK3B+AXIN+APC) -| CTNNB1 -> TCF/LEF => (MYC,CCND1)

description_full:
  FZD7-overexpression to Wnt signaling pathway. Pathway ID: N00059. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: WNT5A -> (FZD,(ROR1,ROR2)) -> DVL
systematic_name: M47823
exact_source: N01427
external_details_URL: https://www.kegg.jp/entry/N01427
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  WNT5A-ROR signaling pathway. Pathway ID: N01427. Pathway type: Reference. Pathway class: nt06505 WNT signaling.


description_brief: Pathway Definition from KEGG: EWSR1-WT1 => (PDGFA,IL2RB,BAIAP3,TSPAN7,MLF1)
systematic_name: M47446
exact_source: N00137
external_details_URL: https://www.kegg.jp/entry/N00137
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EWSR1-WT1 fusion to transcriptional activation. Pathway ID: N00137. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: Ca2+(extracellular) -- CAV -> Ca2+(cyto)
systematic_name: M47948
exact_source: N01637
external_details_URL: https://www.kegg.jp/entry/N01637
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+ entry, Voltage-gated Ca2+ channel. Pathway ID: N01637. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


systematic_name: M47950
exact_source: N01639
external_details_URL: https://www.kegg.jp/entry/N01639
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Ca2+(extracellular) -- CAV1.2 -> Ca2+(cyto) -> (RYR2+TRDN+JCN+CASQ) -> Ca2+(cyto)

description_full:
  Cardiac-type VGCC-RYR signaling. Pathway ID: N01639. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


systematic_name: M47509
exact_source: N00302
external_details_URL: https://www.kegg.jp/entry/N00302
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (CACNA1D*,CACNA1H*) -> Ca2+ -> CALM -> CAMK -> CREB => CYP11B2 -> Aldosterone

description_full:
  Mutation-activated CACNA1D/H to angiotensin-aldosterone signaling pathway. Pathway ID: N00302. Pathway type: Variant. Pathway class: nt06316 Renin-angiotensin-aldosterone signaling.


systematic_name: M47666
exact_source: N00967
external_details_URL: https://www.kegg.jp/entry/N00967
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Ca2+(extracellular) -- VGCC -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)

description_full:
  VGCC-Ca2+ -apoptotic pathway. Pathway ID: N00967. Pathway type: Reference. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: CAV1.1 -> (RYR1+TRDN+JCN+CASQ) -> Ca2+(cyto)
systematic_name: M47949
exact_source: N01638
external_details_URL: https://www.kegg.jp/entry/N01638
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Skeletal-type VGCC-RYR signaling. Pathway ID: N01638. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


systematic_name: M47632
exact_source: N00820
external_details_URL: https://www.kegg.jp/entry/N00820
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: G00009 -- MOGS >> GANAB >> MAN1 >> MGAT1 >> MAN2 >> MGAT2 >> FUT8 >> B4GALT >> ST6GAL -> G00018

description_full:
  N-Glycan biosynthesis. Pathway ID: N00820. Pathway type: Reference. Pathway class: nt06015 N-Glycan biosynthesis.


description_brief: Pathway Definition from KEGG: (EspG,EspG2) -| (TUBA+TUBB)
systematic_name: M47768
exact_source: N01286
external_details_URL: https://www.kegg.jp/entry/N01286
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia EspG to Microtubule-RHOA signaling pathway. Pathway ID: N01286. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: (TUBA+TUBB) -| ARHGEF2 -> RHOA -> ROCK1/2
systematic_name: M47767
exact_source: N01285
external_details_URL: https://www.kegg.jp/entry/N01285
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Microtubule-RHOA signaling pathway. Pathway ID: N01285. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: PAX8-PPARG -| (RXR+PPARG)
systematic_name: M49023
exact_source: N00126
external_details_URL: https://www.kegg.jp/entry/N00126
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PAX8-PPARG fusion to PPARG-mediated transcription. Pathway ID: N00126. Pathway type: Variant. Pathway class: nt06274 Thyroid cancer.


description_brief: Pathway Definition from KEGG: Env -> (CXCR4,CCR5) -> GNAI -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47559
exact_source: N00431
external_details_URL: https://www.kegg.jp/entry/N00431
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIV gp120 to CXCR4-GNAI-PI3K-BAD signaling pathway. Pathway ID: N00431. Pathway type: Pathogen. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


systematic_name: M47560
exact_source: N00432
external_details_URL: https://www.kegg.jp/entry/N00432
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Env -> (CXCR4,CCR5) -> GNAQ -> PLCG -> IP3 -> Ca2+ -> CALM == CN -> NFAT

description_full:
  HIV gp120 to CXCR4-GNAQ-PLCB/G-calcineurin. Pathway ID: N00432. Pathway type: Pathogen. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: Env -> (CXCR4,CCR5) -> GNB/G -> RAC -> PAK1 -> LIMK1 -> CFL
systematic_name: M47562
exact_source: N00434
external_details_URL: https://www.kegg.jp/entry/N00434
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIV gp120 to CXCR4-GNB/G-RAC signaling pathway. Pathway ID: N00434. Pathway type: Pathogen. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: EBNA1 -| USP7 -> TP53 => (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
systematic_name: M47477
exact_source: N00223
external_details_URL: https://www.kegg.jp/entry/N00223
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA1 to p53-mediated transcription. Pathway ID: N00223. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: RAB7 == (EPG5,PLEKHM1,BIRC6,HOPS,TECPR2) == LC3-II
systematic_name: M47978
exact_source: N01721
external_details_URL: https://www.kegg.jp/entry/N01721
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagosome and lysosome fusion, tethering factor. Pathway ID: N01721. Pathway type: Reference. Pathway class: nt06532 Autophagy.


systematic_name: M47773
exact_source: N01295
external_details_URL: https://www.kegg.jp/entry/N01295
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: RAB7 == RILP == OSBPL1A == (DYNC+DYNL+DCTN+ACTR1+ACTR10) == (TUBA+TUBB)

description_full:
  Rab7-regulated microtubule minus-end directed transport. Pathway ID: N01295. Pathway type: Reference. Pathway class: nt06125 Membrane trafficking (bacteria).


description_brief: Pathway Definition from KEGG: (EPM2A+NHLRC1) -> (BECN1,PIK3C3,PIK3R4,ATG14,UVRAG)
systematic_name: M47977
exact_source: N01719
external_details_URL: https://www.kegg.jp/entry/N01719
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagy-vesicle nucleation/elongation/maturation, E3 ubiquitin-ligase Malin. Pathway ID: N01719. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: glycosylase -> TDP1+PNKP == POLB+XRCC1 == PARP
systematic_name: M47830
exact_source: N01435
external_details_URL: https://www.kegg.jp/entry/N01435
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Base excision and strand cleavage by NEIL glycosylase. Pathway ID: N01435. Pathway type: Reference. Pathway class: nt06504 Base excision repair.


description_brief: Pathway Definition from KEGG: Ca2+(cyto) -> CALM == CN -> NFAT
systematic_name: M47956
exact_source: N01647
external_details_URL: https://www.kegg.jp/entry/N01647
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+/CAM-CN signaling pathway. Pathway ID: N01647. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: Ca2+(cyto) == CALM == (CAV,RYR)
systematic_name: M47958
exact_source: N01649
external_details_URL: https://www.kegg.jp/entry/N01649
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+/CAM-VGCC/RYR signaling pathway. Pathway ID: N01649. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: Ca2+(cyto) -> CALM == CAMK
systematic_name: M47957
exact_source: N01648
external_details_URL: https://www.kegg.jp/entry/N01648
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Ca2+/CAM-CAMK signaling pathway. Pathway ID: N01648. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: RUBCNL -| RUBCN -| PI3KC3-C2
systematic_name: M47976
exact_source: N01718
external_details_URL: https://www.kegg.jp/entry/N01718
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagy-vesicle nucleation/elongation/maturation, PACER-RUBCN-PI3KC3-C2. Pathway ID: N01718. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: (SLC7A5+SLC3A2) -> FLCN -> (RRAGA+RRAGB+RRAGC+RRAGD) -> mTORC1
systematic_name: M47922
exact_source: N01584
external_details_URL: https://www.kegg.jp/entry/N01584
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  FLCN-mTORC1 signaling pathway. Pathway ID: N01584. Pathway type: Reference. Pathway class: nt06522 mTOR signaling.


description_brief: Pathway Definition from KEGG: (LZTR1+CUL3) -| (RAS,RIT1)
systematic_name: M47931
exact_source: N01596
external_details_URL: https://www.kegg.jp/entry/N01596
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of GF-RTK-RAS-ERK signaling, RAS ubiquitination by CUL3 complex. Pathway ID: N01596. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


systematic_name: M47868
exact_source: N01482
external_details_URL: https://www.kegg.jp/entry/N01482
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Cohesin -> ATRX == Cohesin == NIPBL+MAU2 -> DDX11 == Cohesin+NIPBL+MAU2

description_full:
  Cohesin loading. Pathway ID: N01482. Pathway type: Reference. Pathway class: nt06512 Chromosome cohesion and segregation.


description_brief: Pathway Definition from KEGG: PR-DUB -| cPRC1
systematic_name: M47923
exact_source: N01585
external_details_URL: https://www.kegg.jp/entry/N01585
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Deubiquitination of H2AK119. Pathway ID: N01585. Pathway type: Reference. Pathway class: nt06523 Epigenetic regulation by Polycomb complexes.


description_brief: Pathway Definition from KEGG: CMG+TRAIP -> CMG == MCM7+Ub -> MCM7+VCP+UFD1+NPL4
systematic_name: M47862
exact_source: N01474
external_details_URL: https://www.kegg.jp/entry/N01474
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TRAIP-dependent replisome disassembly. Pathway ID: N01474. Pathway type: Reference. Pathway class: nt06509 DNA replication.


systematic_name: M47859
exact_source: N01471
external_details_URL: https://www.kegg.jp/entry/N01471
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: CMG+POLE+MCM10 == POLA+PRIM == RPA -> CMG+MCM10+CTF4+POLA+POLE == RFC+PCNA

description_full:
  Origin unwinding and elongation. Pathway ID: N01471. Pathway type: Reference. Pathway class: nt06509 DNA replication.


description_brief: Pathway Definition from KEGG: CMG+PIF1 -> CMG+CRL2-LRR1 -> CMG == MCM7+Ub -> MCM7+VCP+UFD1+NPL4
systematic_name: M47861
exact_source: N01473
external_details_URL: https://www.kegg.jp/entry/N01473
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  DNA replication termination. Pathway ID: N01473. Pathway type: Reference. Pathway class: nt06509 DNA replication.


description_brief: Pathway Definition from KEGG: LPS -> CASP4/5 -> (NLRP3+PYCARD+CASP1) -> (IL1B,IL18)
systematic_name: M47651
exact_source: N00934
external_details_URL: https://www.kegg.jp/entry/N00934
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Non-canonical inflammasome signaling pathway. Pathway ID: N00934. Pathway type: Reference. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: MAD1L1 -> (MAD2L1/2+BUB1B+BUB3) -| (ANAPC+CDC20) -| PTTG -| ESPL1
systematic_name: M47583
exact_source: N00493
external_details_URL: https://www.kegg.jp/entry/N00493
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Spindle assembly checkpoint signaling. Pathway ID: N00493. Pathway type: Reference. Pathway class: nt06230 Cell cycle.


systematic_name: M47965
exact_source: N01666
external_details_URL: https://www.kegg.jp/entry/N01666
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: LacCer -- B3GNT5 >> B4GALT1/2/3/4 -> nLc4Cer -- FUT1*H -> TypeIIH // ABO*O

description_full:
  Blood group H (O) antigen type 2 biosynthesis. Pathway ID: N01666. Pathway type: Reference. Pathway class: nt06035 Blood group carbohydrate antigen biosynthesis.


systematic_name: M47959
exact_source: N01651
external_details_URL: https://www.kegg.jp/entry/N01651
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: LacCer -- B3GNT5 >> B3GALT1/2/5 -> Lc4Cer -- FUT2*H -> TypeIH // ABO*O

description_full:
  Blood group H (O) antigen type 1 biosynthesis. Pathway ID: N01651. Pathway type: Reference. Pathway class: nt06035 Blood group carbohydrate antigen biosynthesis.


systematic_name: M47571
exact_source: N00449
external_details_URL: https://www.kegg.jp/entry/N00449
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (Tat,Nef) -> CASP8 -> BID -> (BAX,BAK1) -> CYCS == APAF1 -> CASP9 -> CASP3

description_full:
  HIV Tat/Nef to crosstalk between extrinsic and intrinsic apoptotic pathways. Pathway ID: N00449. Pathway type: Pathogen. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: PRC1.6 -- (MGA,MAX+L3MBTL2+E2F6) -- H2AK119+UB -> PRC2.2
systematic_name: M47941
exact_source: N01614
external_details_URL: https://www.kegg.jp/entry/N01614
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Activation of PRC2.2 by ubiquitination of H2AK119 in germline genes. Pathway ID: N01614. Pathway type: Reference. Pathway class: nt06523 Epigenetic regulation by Polycomb complexes.


description_brief: Pathway Definition from KEGG: PROK1/2 -> PROKR1/2 -> GNAI -> ERK
systematic_name: M47641
exact_source: N00879
external_details_URL: https://www.kegg.jp/entry/N00879
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PROK-PRKR-Gi-ERK signaling pathway. Pathway ID: N00879. Pathway type: Reference. Pathway class: nt06361 Hypogonadotropic hypogonadism.


description_brief: Pathway Definition from KEGG: PROK1/2 -> PROKR2* -> GNAI -> ERK
systematic_name: M47643
exact_source: N00881
external_details_URL: https://www.kegg.jp/entry/N00881
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated PROKR2 to PROK-PRKR-Gi-ERK signaling pathway. Pathway ID: N00881. Pathway type: Variant. Pathway class: nt06361 Hypogonadotropic hypogonadism.


description_brief: Pathway Definition from KEGG: LC3 -- ATG4 >> ATG7 >> ATG3 >> (ATG12+ATG5+ATG16L1) -> LC3-II
systematic_name: M47458
exact_source: N00156
external_details_URL: https://www.kegg.jp/entry/N00156
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagy-vesicle nucleation/elongation/maturation, LC3-II formation. Pathway ID: N00156. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: Ca2+ -> CASR -> GNAQ -> PLCB -> IP3 -> Ca2+ -| PTH
systematic_name: M47505
exact_source: N00291
external_details_URL: https://www.kegg.jp/entry/N00291
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CaSR-PTH signaling pathway. Pathway ID: N00291. Pathway type: Reference. Pathway class: nt06318 CaSR-PTH signaling.


description_brief: Pathway Definition from KEGG: PRC1.1 -- (USP7+TRIM27) -- H2AK119+UB -> PRC2.2
systematic_name: M47924
exact_source: N01586
external_details_URL: https://www.kegg.jp/entry/N01586
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Activation of PRC2.2 by ubiquitination of H2AK119. Pathway ID: N01586. Pathway type: Reference. Pathway class: nt06523 Epigenetic regulation by Polycomb complexes.


description_brief: Pathway Definition from KEGG: RUNX1* // (CSF1R,MPO,CSF2,IL3)
systematic_name: M49024
exact_source: N00116
external_details_URL: https://www.kegg.jp/entry/N00116
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated RUNX1 to transcription. Pathway ID: N00116. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: TEL-AML1 == (HDAC+SIN3A+NCOR1) =| (IL3,CSF2,MPO,DEFA3,ELANE,GZMB)
systematic_name: M47438
exact_source: N00118
external_details_URL: https://www.kegg.jp/entry/N00118
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TEL-AML1 fusion to transcriptional repression. Pathway ID: N00118. Pathway type: Variant. Pathway class: nt06240 Transcription.


description_brief: Pathway Definition from KEGG: AML1-ETO -| SPI1 => (CD14,ITGAM,FCGR1A)
systematic_name: M49025
exact_source: N00112
external_details_URL: https://www.kegg.jp/entry/N00112
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  AML1-ETO fusion to PU.1-mediated transcription. Pathway ID: N00112. Pathway type: Variant. Pathway class: nt06275 Acute myeloid leukemia.


description_brief: Pathway Definition from KEGG: CBL -| RTK
systematic_name: M47934
exact_source: N01599
external_details_URL: https://www.kegg.jp/entry/N01599
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of GF-RTK-RAS-ERK signaling, ubiquitination of RTK by CBL. Pathway ID: N01599. Pathway type: Reference. Pathway class: nt06526 MAPK signaling.


description_brief: Pathway Definition from KEGG: (VAMP8,STX7) == SNAP29 == (STX17,YKT6)
systematic_name: M49026
exact_source: N01720
external_details_URL: https://www.kegg.jp/entry/N01720
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagosome and lysosome fusion, trans-SNARE. Pathway ID: N01720. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: PI -- PI3KC3-C1 -> PI3P -> (WIPI,ZFYVE1)
systematic_name: M47974
exact_source: N01715
external_details_URL: https://www.kegg.jp/entry/N01715
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Autophagy-vesicle nucleation/elongation/maturation, PI3P synthesis by PI3KC3-C1. Pathway ID: N01715. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: LMP1 -> (TRADD+TRAF6) -> (TAB1/2+TAK1) -> IKK -> NFKBIA -> NFKB
systematic_name: M47493
exact_source: N00265
external_details_URL: https://www.kegg.jp/entry/N00265
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV LMP1 to NFKB signaling pathway. Pathway ID: N00265. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: GBF1 -> ARF1 == (KDELR+TMED2+TMED10) == (COPI+TMED4/9+TMED1/3/5/6/7)
systematic_name: M47772
exact_source: N01293
external_details_URL: https://www.kegg.jp/entry/N01293
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  COPI vesicle formation. Pathway ID: N01293. Pathway type: Reference. Pathway class: nt06125 Membrane trafficking (bacteria).


systematic_name: M47567
exact_source: N00442
external_details_URL: https://www.kegg.jp/entry/N00442
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Nef -> (RIPK1+TRADD+TRAF2/5) -> (TAB1/2/3+TAK1) -> IKK -> NFKBIA -> NFKB

description_full:
  HIV Nef to TNF-NFKB signaling pathway. Pathway ID: N00442. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: TNFSF14 -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB
systematic_name: M47599
exact_source: N00559
external_details_URL: https://www.kegg.jp/entry/N00559
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  LIGHT-HVEM-NFKB signaling pathway. Pathway ID: N00559. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: TNFSF10 -> TNFRSF10 -> (RIPK1+RIPK3)
systematic_name: M49027
exact_source: N01631
external_details_URL: https://www.kegg.jp/entry/N01631
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TNFSF10-RIPK1/3 signaling pathway. Pathway ID: N01631. Pathway type: Reference. Pathway class: nt06527 Necroptosis.


systematic_name: M47600
exact_source: N00560
external_details_URL: https://www.kegg.jp/entry/N00560
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: GD -> TNFRSF14 -> TRAF2/5 -> IKK -> NFKBIA -> NFKB => (BIRC2,BIRC3,NFKB1,RELA,CCL2)

description_full:
  HSV gD to HVEM-NFKB signaling pathway. Pathway ID: N00560. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: SucCoA -- SUCL >> SDH >> FH >> MDH1/2 -> OA
systematic_name: M47942
exact_source: N01617
external_details_URL: https://www.kegg.jp/entry/N01617
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Citrate cycle, second carbon oxidation 2. Pathway ID: N01617. Pathway type: Reference. Pathway class: nt06031 Citrate cycle and pyruvate metabolism.


description_brief: Pathway Definition from KEGG: FGF17* // FGFR1 -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47640
exact_source: N00877
external_details_URL: https://www.kegg.jp/entry/N00877
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated FGF17 to RAS-ERK signaling pathway. Pathway ID: N00877. Pathway type: Variant. Pathway class: nt06361 Hypogonadotropic hypogonadism.


description_brief: Pathway Definition from KEGG: EBNA3C -> ((CCNA,CCNE)+CDK2) -> RB1 // E2F
systematic_name: M47578
exact_source: N00482
external_details_URL: https://www.kegg.jp/entry/N00482
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EBV EBNA3C to p27-Cell cycle G1/S. Pathway ID: N00482. Pathway type: Pathogen. Pathway class: nt06165 Epstein-Barr virus (EBV).


description_brief: Pathway Definition from KEGG: (CCNE*+CDK2) -> RB1 // E2F
systematic_name: M47489
exact_source: N00255
external_details_URL: https://www.kegg.jp/entry/N00255
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified CCNE to cell cycle G1/S. Pathway ID: N00255. Pathway type: Variant. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: USP8* -> EGFR -> ERK1/2 -> ACTH
systematic_name: M49028
exact_source: N00319
external_details_URL: https://www.kegg.jp/entry/N00319
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated USP8 to EGFR-ERK-ACTH signaling pathway. Pathway ID: N00319. Pathway type: Variant. Pathway class: nt06310 CRH-ACTH-cortisol signaling.


systematic_name: M47733
exact_source: N01106
external_details_URL: https://www.kegg.jp/entry/N01106
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (TCR+CD3+CD4) -> (LCK,FYN,ZAP70) -> (SLP76+GADS+LAT+VAV) -> PLCG -> IP3 -> ITPR -> Ca2+(cyto)

description_full:
  TCR-PLCG-ITPR signaling pathway. Pathway ID: N01106. Pathway type: Reference. Pathway class: nt06528 Calcium signaling.


description_brief: Pathway Definition from KEGG: (NLRP12+PYCARD) -> CASP1 -> (IL1B,IL18)
systematic_name: M49029
exact_source: N01569
external_details_URL: https://www.kegg.jp/entry/N01569
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  NALP12 inflammasome signaling pathway. Pathway ID: N01569. Pathway type: Reference. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: BMP15 -> (BMPR2+BMPR1B) -> (SMAD1,SMAD5,SMAD9) == SMAD4
systematic_name: M47845
exact_source: N01455
external_details_URL: https://www.kegg.jp/entry/N01455
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  BMP15 signaling pathway. Pathway ID: N01455. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


systematic_name: M47886
exact_source: N01529
external_details_URL: https://www.kegg.jp/entry/N01529
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: AURKB -- NDC80 == MPS1 -- KNL1 == (BUB1+BUB3+BUBR1) == (MAD1+MAD2) -> KNL1+MCC

description_full:
  Recruitment and formation of the MCC. Pathway ID: N01529. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


systematic_name: M47885
exact_source: N01526
external_details_URL: https://www.kegg.jp/entry/N01526
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: CPC == CENPC == MIS12C+KNL1C+CENP-TWSX -> CPC+CENPC+MIS12C+KNLC == CENP-TWSX == NDC80C

description_full:
  Organization of the outer kinetochore. Pathway ID: N01526. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: AURKB,CDK1 -- NCAPD2,NCAPG,NCAPH
systematic_name: M49030
exact_source: N01500
external_details_URL: https://www.kegg.jp/entry/N01500
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Modifying of condensin I subunits. Pathway ID: N01500. Pathway type: Reference. Pathway class: nt06512 Chromosome cohesion and segregation.


description_brief: Pathway Definition from KEGG: MAGI -> PTEN -| PIP3 -> AKT
systematic_name: M47523
exact_source: N00342
external_details_URL: https://www.kegg.jp/entry/N00342
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  MAGI-PTEN signaling pathway. Pathway ID: N00342. Pathway type: Reference. Pathway class: nt06166 Human papillomavirus (HPV).


description_brief: Pathway Definition from KEGG: (STRADA+STRADB+STK11) -> (PRKAA1+PPKAA2) -> (TSC1+TSC2+TBC1D7)
systematic_name: M47916
exact_source: N01576
external_details_URL: https://www.kegg.jp/entry/N01576
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  STRAD/STK11- TSC signaling pathway. Pathway ID: N01576. Pathway type: Reference. Pathway class: nt06522 mTOR signaling.


description_brief: Pathway Definition from KEGG: (NOG,GREM,CHRD,NBL1) -| BMP
systematic_name: M47824
exact_source: N01428
external_details_URL: https://www.kegg.jp/entry/N01428
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  BMP signaling pathway, BMP antagonist. Pathway ID: N01428. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: TRIP13+MAD2L1BP -| MCC -| ANAPC
systematic_name: M47888
exact_source: N01533
external_details_URL: https://www.kegg.jp/entry/N01533
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Disassembly of MCC. Pathway ID: N01533. Pathway type: Reference. Pathway class: nt06515 Regulation of kinetochore-microtubule interactions.


description_brief: Pathway Definition from KEGG: Map -> NHERF1 -> EZR -> RHOA -> ROCK1/2
systematic_name: M49031
exact_source: N01095
external_details_URL: https://www.kegg.jp/entry/N01095
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia Map to LPA-GNA12/13-RhoA signaling pathway. Pathway ID: N01095. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: (CD80,CD86) -> CTLA4 -> PP2A -| AKT
systematic_name: M47919
exact_source: N01579
external_details_URL: https://www.kegg.jp/entry/N01579
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CD80/CD86-CTLA4-PP2A signaling pathway. Pathway ID: N01579. Pathway type: Reference. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: (CD80,CD86) -> CD28 -> PI3K -> PIP3 -> AKT -| GSK3B
systematic_name: M47615
exact_source: N00683
external_details_URL: https://www.kegg.jp/entry/N00683
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CD80/CD86-CD28-PI3K signaling pathway. Pathway ID: N00683. Pathway type: Reference. Pathway class: nt06530 PI3K signaling.


description_brief: Pathway Definition from KEGG: ATG5/7 -> NCOA4 -- (Fe3++(FTH1+FTL))
systematic_name: M49032
exact_source: N01588
external_details_URL: https://www.kegg.jp/entry/N01588
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Fe3+ Ferritin transport. Pathway ID: N01588. Pathway type: Reference. Pathway class: nt06525 Ferroptosis.


description_brief: Pathway Definition from KEGG: CD40LG -> CD40 -> (TRAF2+TRAF3) -> NIK -> IKKA -> (NFKB2+RELB)
systematic_name: M47587
exact_source: N00505
external_details_URL: https://www.kegg.jp/entry/N00505
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CD40-NFKB signaling pathway. Pathway ID: N00505. Pathway type: Reference. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: (CD59,CLU,VTN) -| (C5b+C6+C7+C8+C9)
systematic_name: M47881
exact_source: N01505
external_details_URL: https://www.kegg.jp/entry/N01505
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Regulation of complement cascade, MAC inhibition. Pathway ID: N01505. Pathway type: Reference. Pathway class: nt06513 Complement cascade.


description_brief: Pathway Definition from KEGG: CD74 -> MHCII
systematic_name: M47604
exact_source: N00590
external_details_URL: https://www.kegg.jp/entry/N00590
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Antigen processing and presentation by MHC class II molecules. Pathway ID: N00590. Pathway type: Reference. Pathway class: nt06168 Herpes simplex virus 1 (HSV-1).


description_brief: Pathway Definition from KEGG: Vpr == (DCAF1+DDB1+CUL4) -> ATR -> CHEK1 -| CDC25C -> (CCNB+CDK1)
systematic_name: M47573
exact_source: N00456
external_details_URL: https://www.kegg.jp/entry/N00456
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HIV Vpr to CDC25-cell cycle G2M. Pathway ID: N00456. Pathway type: Pathogen. Pathway class: nt06161 Human immunodeficiency virus 1 (HIV-1).


description_brief: Pathway Definition from KEGG: Metals -> ROS -| KEAP1 -| NRF2 => (HMOX1,NQO1,AKR)
systematic_name: M47817
exact_source: N01413
external_details_URL: https://www.kegg.jp/entry/N01413
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Metals to KEAP1-NRF2 signalig pathway. Pathway ID: N01413. Pathway type: Env factor. Pathway class: nt06226 KEAP1-NRF2 signaling.


description_brief: Pathway Definition from KEGG: SifA == PLEKHM1 == RAB7 == HOPS
systematic_name: M47777
exact_source: N01301
external_details_URL: https://www.kegg.jp/entry/N01301
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Salmonella SifA to Tethering of late endosomes and lysosomes. Pathway ID: N01301. Pathway type: Pathogen. Pathway class: nt06125 Membrane trafficking (bacteria).


systematic_name: M47821
exact_source: N01425
external_details_URL: https://www.kegg.jp/entry/N01425
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (CRL4+DDB2) == (XPC+RAD23A,RAD23B+CETN2) -> (XPC+CETN2) == (ERCC3+ERCC2) == (GTF2H) == (CAK)

description_full:
  Global genome NER. Pathway ID: N01425. Pathway type: Reference. Pathway class: nt06502 Nucleotide excision repair.


description_brief: Pathway Definition from KEGG: SopE/E2 -> CDC42 -> NOD1 -> RIPK2 -> IKK -> NFKBIA -> NFKB
systematic_name: M47734
exact_source: N01112
external_details_URL: https://www.kegg.jp/entry/N01112
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Salmonella SopE/E2 to NOD-NFKB signaling pathway. Pathway ID: N01112. Pathway type: Pathogen. Pathway class: nt06521 NLR signaling.


description_brief: Pathway Definition from KEGG: Map -> CDC42 -> WASL -> ARP2/3 -> (ACTB,ACTG1)
systematic_name: M47730
exact_source: N01096
external_details_URL: https://www.kegg.jp/entry/N01096
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Escherichia Map to CDC42 signaling pathway. Pathway ID: N01096. Pathway type: Pathogen. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: CDKN1B* // (CCNE+CDK2) -> RB1 // E2F
systematic_name: M47429
exact_source: N00093
external_details_URL: https://www.kegg.jp/entry/N00093
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Loss of CDKN1B to p27-cell cycle G1/S. Pathway ID: N00093. Pathway type: Variant. Pathway class: nt06272 Prostate cancer.


description_brief: Pathway Definition from KEGG: CDKN2A -| MDM2 -| TP53 => CDKN1A -| (CCND+CDK4/6) -> RB1 // E2F
systematic_name: M47416
exact_source: N00066
external_details_URL: https://www.kegg.jp/entry/N00066
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  MDM2-p21-Cell cycle G1/S. Pathway ID: N00066. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: CDKN2A -| (CCND+CDK4/6) -> RB1 // E2F
systematic_name: M47418
exact_source: N00069
external_details_URL: https://www.kegg.jp/entry/N00069
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  p16-Cell cycle G1/S. Pathway ID: N00069. Pathway type: Reference. Pathway class: nt06262 Pancreatic cancer.


description_brief: Pathway Definition from KEGG: ACh -> CHRNA7 -> Ca2+ -> PI3K -> PIP3 -> AKT
systematic_name: M47790
exact_source: N01338
external_details_URL: https://www.kegg.jp/entry/N01338
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ACH-CHRN-PI3K signaling pathway. Pathway ID: N01338. Pathway type: Reference. Pathway class: nt06214 PI3K signaling.


description_brief: Pathway Definition from KEGG: vFLIP -> IKK -> NFKBIA -> NFKB
systematic_name: M47462
exact_source: N00171
external_details_URL: https://www.kegg.jp/entry/N00171
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV vFLIP to NFKB signaling pathway. Pathway ID: N00171. Pathway type: Pathogen. Pathway class: nt06516 TNF signaling.


description_brief: Pathway Definition from KEGG: P4 -> mPR -> PI3K -> PIP3 -> AKT
systematic_name: M47802
exact_source: N01356
external_details_URL: https://www.kegg.jp/entry/N01356
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Membrane-initiated progesterone signaling pathway. Pathway ID: N01356. Pathway type: Reference. Pathway class: nt06214 PI3K signaling.


systematic_name: M47808
exact_source: N01381
external_details_URL: https://www.kegg.jp/entry/N01381
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: NNK -- (AKR1C2,CBR1,HSD11B1) >> (CYP2A6,CYP2A13) -> C19577 -> C19568 -> C20302 == DNA

description_full:
  NNK to DNA adducts. Pathway ID: N01381. Pathway type: Env factor. Pathway class: nt06250 DNA adduct formation.


description_brief: Pathway Definition from KEGG: EGF -> (ERBB2+EGFR) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47381
exact_source: N00021
external_details_URL: https://www.kegg.jp/entry/N00021
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EGF-ERBB2-RAS-ERK signaling pathway. Pathway ID: N00021. Pathway type: Reference. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: EGF -> (ERBB2*+EGFR) -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47393
exact_source: N00034
external_details_URL: https://www.kegg.jp/entry/N00034
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ERBB2-overexpression to PI3K signaling pathway. Pathway ID: N00034. Pathway type: Variant. Pathway class: nt06262 Pancreatic cancer.


description_brief: Pathway Definition from KEGG: EGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
systematic_name: M47375
exact_source: N00014
external_details_URL: https://www.kegg.jp/entry/N00014
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated EGFR to RAS-ERK signaling pathway. Pathway ID: N00014. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: EGFR* -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47400
exact_source: N00042
external_details_URL: https://www.kegg.jp/entry/N00042
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EGFR-overexpression to PI3K signaling pathway. Pathway ID: N00042. Pathway type: Variant. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: EGFR* -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47395
exact_source: N00036
external_details_URL: https://www.kegg.jp/entry/N00036
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated EGFR to PI3K signaling pathway. Pathway ID: N00036. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: EREG -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47496
exact_source: N00277
external_details_URL: https://www.kegg.jp/entry/N00277
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  EREG-EGFR-RAS-ERK signaling pathway. Pathway ID: N00277. Pathway type: Reference. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: nLc4Cer -- FUT3/4/5/6/9 -> Lex
systematic_name: M47966
exact_source: N01672
external_details_URL: https://www.kegg.jp/entry/N01672
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Lewis x antigen biosynthesis. Pathway ID: N01672. Pathway type: Reference. Pathway class: nt06035 Blood group carbohydrate antigen biosynthesis.


systematic_name: M47638
exact_source: N00873
external_details_URL: https://www.kegg.jp/entry/N00873
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: GNRH1/2 -> GNRHR -> (GNAQ,GNA11) -> PLCB -> (Ca2+,DAG) -> PKC -> RAF1 -> MEK -> ERK -> ELK1 => (LHB,CGA,FSHB)

description_full:
  GnRH-GnRHR-PLCB-PKC signaling pathway. Pathway ID: N00873. Pathway type: Reference. Pathway class: nt06323 KISS1-GnRH-LH/FSH-E2 signaling.


systematic_name: M49033
exact_source: N00956
external_details_URL: https://www.kegg.jp/entry/N00956
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: Glutamate -> GRM1 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -> PRKCG* -| TRPC3

description_full:
  Mutation-activated PRKCG to mGluR1-TRPC3 signaling pathway. Pathway ID: N00956. Pathway type: Variant. Pathway class: nt06462 Spinocerebellar ataxia.


description_brief: Pathway Definition from KEGG: TBK1 -> (SQSTM1,OPTN,NDP52,TAX1BP1,NBR1) == LC3-II
systematic_name: M47745
exact_source: N01140
external_details_URL: https://www.kegg.jp/entry/N01140
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TBK1-mediated autophagosome formation. Pathway ID: N01140. Pathway type: Reference. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: (GSK3B+AXIN) // APC* // CTNNB1 -> TCF/LEF => (BIRC5,MYC,CCND1)
systematic_name: M47410
exact_source: N00057
external_details_URL: https://www.kegg.jp/entry/N00057
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated APC to Wnt signaling pathway. Pathway ID: N00057. Pathway type: Variant. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: (ANXA2+S100A10) == AHNAK == (ACTB,ACTG1)
systematic_name: M49034
exact_source: N01304
external_details_URL: https://www.kegg.jp/entry/N01304
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  ANXA2-S100A10-regulated actin cytoskeleton. Pathway ID: N01304. Pathway type: Reference. Pathway class: nt06135 Cytoskeletal regulation (viruses and bacteria).


description_brief: Pathway Definition from KEGG: HGF -> MET -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47401
exact_source: N00043
external_details_URL: https://www.kegg.jp/entry/N00043
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HGF-MET-PI3K signaling pathway. Pathway ID: N00043. Pathway type: Reference. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: HGF -> MET -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47473
exact_source: N00216
external_details_URL: https://www.kegg.jp/entry/N00216
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HGF-MET-RAS-ERK signaling pathway. Pathway ID: N00216. Pathway type: Reference. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: (MIR1,MIR2) -| MHCI
systematic_name: M47468
exact_source: N00184
external_details_URL: https://www.kegg.jp/entry/N00184
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KSHV MIR1/2 to antigen processing and presentation by MHC class I molecules. Pathway ID: N00184. Pathway type: Pathogen. Pathway class: nt06229 MHC presentation.


description_brief: Pathway Definition from KEGG: HRAS* -> RAF -> MEK -> ERK -> MSK1 -> MYC
systematic_name: M47420
exact_source: N00077
external_details_URL: https://www.kegg.jp/entry/N00077
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HRAS-overexpression to ERK signaling pathway. Pathway ID: N00077. Pathway type: Variant. Pathway class: nt06265 Bladder cancer.


description_brief: Pathway Definition from KEGG: IGF2* -> IGF1R -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47485
exact_source: N00235
external_details_URL: https://www.kegg.jp/entry/N00235
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  IGF2-overexpression to RAS-ERK signaling pathway. Pathway ID: N00235. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: IGF2 -> IGF1R -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47484
exact_source: N00234
external_details_URL: https://www.kegg.jp/entry/N00234
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  IGF2-IGF1R-PI3K signaling pathway. Pathway ID: N00234. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: AREG -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47497
exact_source: N00279
external_details_URL: https://www.kegg.jp/entry/N00279
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  AREG-EGFR-RAS-ERK signaling pathway. Pathway ID: N00279. Pathway type: Reference. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: (KIF5+KLC) == (TUBA+TUBB)
systematic_name: M47671
exact_source: N00978
external_details_URL: https://www.kegg.jp/entry/N00978
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Anterograde axonal transport. Pathway ID: N00978. Pathway type: Reference. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: KISS1 -> KISS1R -> (GNAQ,GNA11) -> PLCB -> (Ca2+,DAG) -> PKC
systematic_name: M47637
exact_source: N00869
external_details_URL: https://www.kegg.jp/entry/N00869
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  KISS1-KISS1R-PLCB-PKC signaling pathway. Pathway ID: N00869. Pathway type: Reference. Pathway class: nt06323 KISS1-GnRH-LH/FSH-E2 signaling.


description_brief: Pathway Definition from KEGG: MET* -> GAB1 -> PI3K -> PIP3 -> AKT -> MTOR
systematic_name: M47490
exact_source: N00260
external_details_URL: https://www.kegg.jp/entry/N00260
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified MET to PI3K signaling pathway. Pathway ID: N00260. Pathway type: Variant. Pathway class: nt06261 Gastric cancer.


description_brief: Pathway Definition from KEGG: MET* -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD
systematic_name: M47402
exact_source: N00044
external_details_URL: https://www.kegg.jp/entry/N00044
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated MET to PI3K signaling pathway. Pathway ID: N00044. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: MET* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47488
exact_source: N00248
external_details_URL: https://www.kegg.jp/entry/N00248
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  MET-overexpression to RAS-ERK signaling pathway. Pathway ID: N00248. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: NADH -- CxI -> Q
systematic_name: M47683
exact_source: N00995
external_details_URL: https://www.kegg.jp/entry/N00995
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Electron transfer in Complex I. Pathway ID: N00995. Pathway type: Reference. Pathway class: nt06460 Alzheimer disease.


description_brief: Pathway Definition from KEGG: (MYC+MAX) -| ZBTB17 => CDKN2B -| (CCND+CDK4/6) -> RB1 // E2F
systematic_name: M49035
exact_source: N00090
external_details_URL: https://www.kegg.jp/entry/N00090
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  p15-Cell cycle G1/S. Pathway ID: N00090. Pathway type: Reference. Pathway class: nt06267 Small cell lung cancer.


systematic_name: M47752
exact_source: N01152
external_details_URL: https://www.kegg.jp/entry/N01152
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (mRNA(nuclear)+CBP+ALY+SR+TAP+p15) -- (NPC+GLE1+DDX19B) -> (mRNA(cytoplasmic),CBP,ALY,SR,TAP,p15)

description_full:
  Nuclear export of mRNA. Pathway ID: N01152. Pathway type: Reference. Pathway class: nt06464 Amyotrophic lateral sclerosis.


description_brief: Pathway Definition from KEGG: PDGF -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47376
exact_source: N00015
external_details_URL: https://www.kegg.jp/entry/N00015
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  PDGF-PDGFR-RAS-ERK signaling pathway. Pathway ID: N00015. Pathway type: Reference. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: P4 -> (PGR+SRC) -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK -> CCND1
systematic_name: M47804
exact_source: N01360
external_details_URL: https://www.kegg.jp/entry/N01360
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  P4-PR-RAS-ERK signaling pathway. Pathway ID: N01360. Pathway type: Reference. Pathway class: nt06210 ERK signaling.


description_brief: Pathway Definition from KEGG: P4 -> (PGR+SRC) -> PI3K -> PIP3 -> AKT
systematic_name: M47803
exact_source: N01358
external_details_URL: https://www.kegg.jp/entry/N01358
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  P4-PR-PI3K signaling pathway. Pathway ID: N01358. Pathway type: Reference. Pathway class: nt06214 PI3K signaling.


description_brief: Pathway Definition from KEGG: PI3K* -> PIP3 -> AKT -> MTOR -> S6K
systematic_name: M47407
exact_source: N00049
external_details_URL: https://www.kegg.jp/entry/N00049
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-activated PI3K to PI3K signaling pathway. Pathway ID: N00049. Pathway type: Variant. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: As -- AS3MT >> GSTO1 -> MMA -| CxII
systematic_name: M47810
exact_source: N01392
external_details_URL: https://www.kegg.jp/entry/N01392
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Arsenic to electron transfer in complex II. Pathway ID: N01392. Pathway type: Pathogen. Pathway class: nt06252 Mitochondrial ROS formation.


description_brief: Pathway Definition from KEGG: RAB1A -> (C9orf72+WDR41+SMCR8) -> ULK1_complex
systematic_name: M47746
exact_source: N01142
external_details_URL: https://www.kegg.jp/entry/N01142
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  C9orf72-mediated autophagy initiation. Pathway ID: N01142. Pathway type: Reference. Pathway class: nt06532 Autophagy.


description_brief: Pathway Definition from KEGG: (CCND+CDK4*) -> RB1 // E2F
systematic_name: M47419
exact_source: N00072
external_details_URL: https://www.kegg.jp/entry/N00072
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Amplified CDK4 to cell cycle G1/S. Pathway ID: N00072. Pathway type: Variant. Pathway class: nt06273 Glioma.


description_brief: Pathway Definition from KEGG: RET* -> RAS -> RAF -> MEK -> ERK
systematic_name: M47370
exact_source: N00008
external_details_URL: https://www.kegg.jp/entry/N00008
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  RET fusion kinase to RAS-ERK signaling pathway. Pathway ID: N00008. Pathway type: Variant. Pathway class: nt06266 Non-small cell lung cancer.


description_brief: Pathway Definition from KEGG: UB(chain) -- UCHL1 -> UB(free)
systematic_name: M49036
exact_source: N01027
external_details_URL: https://www.kegg.jp/entry/N01027
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  UCHL1-mediated hydrolysis. Pathway ID: N01027. Pathway type: Reference. Pathway class: nt06463 Parkinson disease.


description_brief: Pathway Definition from KEGG: TAC3 -> TACR3 -> GNAQ -> PLCB -> (Ca2+,DAG) -> PKC
systematic_name: M47644
exact_source: N00882
external_details_URL: https://www.kegg.jp/entry/N00882
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TAC3-TACR3-PLC-PKC signaling pathway. Pathway ID: N00882. Pathway type: Reference. Pathway class: nt06323 KISS1-GnRH-LH/FSH-E2 signaling.


description_brief: Pathway Definition from KEGG: TGFA -> EGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
systematic_name: M47480
exact_source: N00229
external_details_URL: https://www.kegg.jp/entry/N00229
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TGFA-EGFR-RAS-ERK signaling pathway. Pathway ID: N00229. Pathway type: Reference. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: TGFA -> EGFR -> PLCG -> IP3 -> (Ca2+,DAG) -> PKC -> ELK1
systematic_name: M47479
exact_source: N00227
external_details_URL: https://www.kegg.jp/entry/N00227
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TGFA-EGFR-PLCG-PKC signaling pathway. Pathway ID: N00227. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: TGFB -> (TGFBR2+TGFBR1) -> (SMAD2,SMAD3) == SMAD4
systematic_name: M47415
exact_source: N00063
external_details_URL: https://www.kegg.jp/entry/N00063
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  TGF-beta signaling pathway. Pathway ID: N00063. Pathway type: Reference. Pathway class: nt06507 TGFB signaling.


description_brief: Pathway Definition from KEGG: TP53* // (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
systematic_name: M47437
exact_source: N00115
external_details_URL: https://www.kegg.jp/entry/N00115
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Mutation-inactivated TP53 to transcription. Pathway ID: N00115. Pathway type: Variant. Pathway class: nt06260 Colorectal cancer.


description_brief: Pathway Definition from KEGG: QH2 -- CxIII -> CytC
systematic_name: M47678
exact_source: N00990
external_details_URL: https://www.kegg.jp/entry/N00990
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  Electron transfer in Complex III. Pathway ID: N00990. Pathway type: Reference. Pathway class: nt06252 Mitochondrial ROS formation.


systematic_name: M47422
exact_source: N00080
external_details_URL: https://www.kegg.jp/entry/N00080
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (VHL*+RBX1+ELOC+ELOB+CUL2) // HIF1A == ARNT => (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)

description_full:
  Loss of VHL to HIF-1 signaling pathway. Pathway ID: N00080. Pathway type: Variant. Pathway class: nt06264 Renal cell carcinoma.


description_brief: Pathway Definition from KEGG: E7 -> (CCNE+CDK2) -> RB1 // E2F
systematic_name: M47527
exact_source: N00360
external_details_URL: https://www.kegg.jp/entry/N00360
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  HPV E7 to p27-cell cycle G1/S. Pathway ID: N00360. Pathway type: Pathogen. Pathway class: nt06166 Human papillomavirus (HPV).


systematic_name: M47487
exact_source: N00243
external_details_URL: https://www.kegg.jp/entry/N00243
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_brief:
  Pathway Definition from KEGG: (O2-,HO2,H2O2,OH,ACRL,4HNE,NO) -| KEAP1 -| NRF2 => (HMOX1,NQO1,GST,TXNRD1)

description_full:
  KEAP1-NRF2 signaling pathway. Pathway ID: N00243. Pathway type: Reference. Pathway class: nt06263 Hepatocellular carcinoma.


description_brief: Pathway Definition from KEGG: CDH1* // CTNNB1 -> TCF/LEF => (MYC,CCND1)
systematic_name: M47413
exact_source: N00061
external_details_URL: https://www.kegg.jp/entry/N00061
source_species_code: HS
contributor: KEGG
contrib_organization: Kyoto Encyclopedia of Genes and Genomes
description_full:
  CDH1-reduced expression to beta-catenin signaling pathway. Pathway ID: N00061. Pathway type: Variant. Pathway class: nt06274 Thyroid cancer.


systematic_name: M19434
source_species_code: HS
contributor: Xiaohui Xie
contrib_organization: Broad Institute
description_brief:
  Genes having at least one occurrence of the motif KDMAYYNTGACCT in the regions spanning 4 kb centered on their transcription starting sites [-2kb, +2kb].  This matches the ESR1 [GeneSymbol=ESR1] transcription factor binding site V$ER_Q6_01 (v7.4 TRANSFAC).


systematic_name: M40145
exact_source: descartes DE_gene_by_organ.csv, fold.change>5, qval<0.05, pval<0.05
external_details_URL: https://descartes.brotmanbaty.org/bbi/human-gene-expression-during-development/
source_species_code: HS
GEO_id: GSE156793
contributor: Anthony Castanza
contrib_organization: MSigDB Team
description_brief:
  Marker genes curated from the annotated cluster as represented in the Descartes Human Gene Expression During Development database.

description_full:
  The gene expression program underlying the specification of human cell types is of fundamental interest. The study authors generated human cell atlases of gene expression and chromatin accessibility in fetal tissues. For gene expression, the study authors applied three-level combinatorial indexing to >110 samples representing 15 organs, ultimately profiling ~4 million single cells. The study authors leveraged the literature and other atlases to identify and annotate hundreds of cell types and subtypes, both within and across tissues. Our analyses focused on organ-specific specializations of broadly distributed cell types (such as blood, endothelial, and epithelial), sites of fetal erythropoiesis (which notably included the adrenal gland), and integration with mouse developmental atlases (such as conserved specification of blood cells). These data represent a rich resource for the exploration of in vivo human gene expression in diverse tissues and cell types.


systematic_name: M26940
exact_source: R-HSA-1362300
external_details_URL: https://www.reactome.org/content/detail/R-HSA-1362300
source_species_code: HS
contributor: Reactome
contrib_organization: Reactome
description_brief:
  Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1


systematic_name: M489
exact_source: R-HSA-141405
external_details_URL: https://www.reactome.org/content/detail/R-HSA-141405
source_species_code: HS
contributor: Reactome
contrib_organization: Reactome
description_brief:
  Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components


