ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A01 compound treatment 6.7265594E7 -8.94E7 -2.34 6.8878447E7 -9.84E7 -2.77 -3.6158 -0.9965 3186889 PK04_093001 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A02 compound treatment 7.9884395E7 -7.68E7 -2.01 7.9853254E7 -8.74E7 -2.46 -3.1636 -0.9949 3067555 PK04_093002 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A03 compound treatment 1.79428404E8 2.27E7 0.59 1.72388286E8 5130000.0 0.14 0.5229 0.854 3186890 PK04_093003 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A04 compound treatment 1.59659401E8 2960000.0 0.08 1.72230973E8 4970000.0 0.14 0.1538 0.9611 3186891 PK04_093004 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A05 compound treatment 1.48350279E8 -8350000.0 -0.22 1.5765686E8 -9610000.0 -0.27 -0.3459 -0.9944 3067558 PK04_093005 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A06 compound treatment 1.06092075E8 -5.06E7 -1.32 1.10872426E8 -5.64E7 -1.59 -2.0604 -0.9959 3186892 PK04_093006 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A07 compound treatment 1.11134315E8 -4.56E7 -1.19 1.11779408E8 -5.55E7 -1.56 -1.949 -0.9911 3067559 PK04_093007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A08 compound treatment 1.56220785E8 -479000.0 -0.01 1.74144292E8 6880000.0 0.19 0.1283 0.6601 3186893 PK04_093008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A09 compound treatment 1.44665005E8 -1.2E7 -0.32 1.64390975E8 -2870000.0 -0.08 -0.28 -0.8608 3186894 PK04_093009 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A10 compound treatment 7.9975936E7 -7.67E7 -2.01 7.9458224E7 -8.78E7 -2.47 -3.1698 -0.9946 3067560 PK04_093010 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A11 compound treatment 1.49253328E8 -7450000.0 -0.19 1.64956806E8 -2310000.0 -0.06 -0.1838 -0.8944 3186895 PK04_093011 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A12 compound treatment 1.27533362E8 -2.92E7 -0.76 1.3667282E8 -3.06E7 -0.86 -1.1494 -0.9982 3186896 PK04_093012 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A13 mock treatment 1.62987472E8 6290000.0 0.16 1.75563602E8 8300000.0 0.23 0.2818 0.9852 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A14 mock treatment 1.49219612E8 -7480000.0 -0.2 1.57038382E8 -1.02E7 -0.29 -0.3422 -0.9823 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A15 compound treatment 7.145902E7 -8.52E7 -2.23 7.2202962E7 -9.51E7 -2.68 -3.472 -0.9959 3067562 PK04_093013 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A16 compound treatment 1.24057873E8 -3.26E7 -0.85 1.52447298E8 -1.48E7 -0.42 -0.8994 -0.9457 3186897 PK04_093014 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A17 compound treatment 1.5335355E8 -3350000.0 -0.09 1.70441429E8 3180000.0 0.09 0.0014 0.0114 3067564 PK04_093015 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A18 compound treatment 9.5984743E7 -6.07E7 -1.59 1.20758088E8 -4.65E7 -1.31 -2.0505 -0.9954 3186898 PK04_093016 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A19 compound treatment 1.35717259E8 -2.1E7 -0.55 1.4237907E8 -2.49E7 -0.7 -0.8842 -0.9927 3186899 PK04_093017 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A20 compound treatment 1.42484852E8 -1.42E7 -0.37 1.44455662E8 -2.28E7 -0.64 -0.7176 -0.9662 3067604 PK04_093018 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A21 compound treatment 1.51027058E8 -5670000.0 -0.15 1.51730237E8 -1.55E7 -0.44 -0.4145 -0.8968 3186900 PK04_093019 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A22 compound treatment 1.69755428E8 1.31E7 0.34 1.63861635E8 -3400000.0 -0.1 0.1739 0.4899 3067607 PK04_093020 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A23 compound treatment 1.90610522E8 3.39E7 0.89 1.88704197E8 2.14E7 0.6 1.055 0.9824 3186901 PK04_093021 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 A24 compound treatment 1.52936171E8 -3760000.0 -0.1 1.36146936E8 -3.11E7 -0.88 -0.6897 -0.7816 3186902 PK04_093022 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B01 compound treatment 1.53808202E8 -2890000.0 -0.08 1.60616887E8 -6650000.0 -0.19 -0.1859 -0.9205 3067612 PK04_093023 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B02 compound treatment 1.53815525E8 -2880000.0 -0.08 1.60443259E8 -6820000.0 -0.19 -0.1893 -0.9167 3186903 PK04_093024 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B03 compound treatment 1.4373205E8 -1.3E7 -0.34 1.4828518E8 -1.9E7 -0.53 -0.6182 -0.9759 3067614 PK04_093025 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B04 compound treatment 1.50541108E8 -6160000.0 -0.16 1.49718608E8 -1.75E7 -0.49 -0.4636 -0.8915 3186904 PK04_093026 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B05 compound treatment 7.7779229E7 -7.89E7 -2.07 9.4668623E7 -7.26E7 -2.05 -2.9073 -1.0 3186905 PK04_093027 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B06 compound treatment 1.41401162E8 -1.53E7 -0.4 1.45691113E8 -2.16E7 -0.61 -0.713 -0.9795 3068180 PK04_093028 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B07 compound treatment 1.29948724E8 -2.68E7 -0.7 1.30335849E8 -3.69E7 -1.04 -1.231 -0.9814 3186906 PK04_093029 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B08 compound treatment 5.8221583E7 -9.85E7 -2.58 6.0165446E7 -1.07E8 -3.02 -3.9569 -0.9969 3186992 PK04_093030 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B09 compound treatment 7.7425878E7 -7.93E7 -2.08 9.606784E7 -7.12E7 -2.01 -2.886 -0.9999 3068181 PK04_093031 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B10 compound treatment 1.10417404E8 -4.63E7 -1.21 1.05013904E8 -6.22E7 -1.75 -2.0971 -0.9837 3186993 PK04_093032 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B11 compound treatment 7.7838321E7 -7.89E7 -2.06 6.8426506E7 -9.88E7 -2.79 -3.4292 -0.9891 3068182 PK04_093033 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B12 compound treatment 1.22727265E8 -3.4E7 -0.89 1.1917291E8 -4.81E7 -1.36 -1.5871 -0.9791 3186994 PK04_093034 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B13 mock treatment 1.46272549E8 -1.04E7 -0.27 1.39599454E8 -2.77E7 -0.78 -0.7442 -0.9011 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B14 mock treatment 1.48585432E8 -8110000.0 -0.21 1.41598844E8 -2.57E7 -0.72 -0.6616 -0.8777 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B15 compound treatment 1.43449646E8 -1.32E7 -0.35 1.55534611E8 -1.17E7 -0.33 -0.4789 -0.9997 3068183 PK04_093035 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B16 compound treatment 1.31630966E8 -2.51E7 -0.66 1.27856312E8 -3.94E7 -1.11 -1.2492 -0.9685 3186995 PK04_093036 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B17 compound treatment 6.631604E7 -9.04E7 -2.37 4.8945122E7 -1.18E8 -3.33 -4.0306 -0.9859 3186996 PK04_093037 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B18 compound treatment 1.49511671E8 -7190000.0 -0.19 1.51848476E8 -1.54E7 -0.43 -0.4402 -0.9299 3068184 PK04_093038 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B19 compound treatment 1.1354196E8 -4.32E7 -1.13 1.13409212E8 -5.39E7 -1.52 -1.8719 -0.9894 3186997 PK04_093039 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B20 compound treatment 1.49350229E8 -7350000.0 -0.19 1.52073733E8 -1.52E7 -0.43 -0.4387 -0.9348 3186998 PK04_093040 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B21 compound treatment 1.35909527E8 -2.08E7 -0.54 1.39494601E8 -2.78E7 -0.78 -0.9381 -0.9843 3068185 PK04_093041 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B22 compound treatment 1.67629789E8 1.09E7 0.29 1.61752716E8 -5510000.0 -0.16 0.0925 0.2843 3186999 PK04_093042 CN(C)C(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B23 compound treatment 1.60782952E8 4080000.0 0.11 1.55766157E8 -1.15E7 -0.32 -0.1535 -0.4499 3068186 PK04_093043 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 B24 compound treatment 1.61287641E8 4590000.0 0.12 1.52891671E8 -1.44E7 -0.4 -0.2014 -0.4769 3187000 PK04_093044 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C01 compound treatment 6.2200725E7 -9.45E7 -2.47 7.0126751E7 -9.71E7 -2.74 -3.6847 -0.9987 3187001 PK04_093045 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C02 compound treatment 1.31147234E8 -2.56E7 -0.67 1.38053971E8 -2.92E7 -0.82 -1.055 -0.9947 3068187 PK04_093046 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C03 compound treatment 1.44534684E8 -1.22E7 -0.32 1.55136471E8 -1.21E7 -0.34 -0.4668 -0.9994 3187002 PK04_093047 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C04 compound treatment 1.49718501E8 -6980000.0 -0.18 1.52734892E8 -1.45E7 -0.41 -0.4187 -0.9339 3068188 PK04_093048 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C05 compound treatment 1.29057773E8 -2.76E7 -0.72 1.41382666E8 -2.59E7 -0.73 -1.0273 -1.0 3187003 PK04_093049 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C06 compound treatment 1.29606882E8 -2.71E7 -0.71 1.38516092E8 -2.87E7 -0.81 -1.0743 -0.9978 3187004 PK04_093050 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C07 compound treatment 1.47131488E8 -9570000.0 -0.25 1.65241549E8 -2020000.0 -0.06 -0.2174 -0.8463 3068189 PK04_093051 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C08 compound treatment 1.31028651E8 -2.57E7 -0.67 1.51678451E8 -1.56E7 -0.44 -0.7857 -0.9787 3187005 PK04_093052 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C09 compound treatment 1.26870279E8 -2.98E7 -0.78 1.55354637E8 -1.19E7 -0.34 -0.7894 -0.9288 3187006 PK04_093053 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C10 compound treatment 8.4782168E7 -7.19E7 -1.88 9.3056486E7 -7.42E7 -2.09 -2.8098 -0.9986 3068190 PK04_093054 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C11 mock treatment 1.453707E8 -1.13E7 -0.3 1.58062492E8 -9200000.0 -0.26 -0.393 -0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C12 mock treatment 1.44799061E8 -1.19E7 -0.31 1.44969363E8 -2.23E7 -0.63 -0.6645 -0.9476 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C13 compound treatment 7.5184106E7 -8.15E7 -2.13 5.764007E7 -1.1E8 -3.09 -3.6932 -0.9837 3187007 PK04_093055 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C14 compound treatment 1.34714439E8 -2.2E7 -0.58 1.31236829E8 -3.6E7 -1.02 -1.1248 -0.9639 3068191 PK04_093056 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C15 mock treatment 1.48670099E8 -8030000.0 -0.21 1.4930627E8 -1.8E7 -0.51 -0.5064 -0.9243 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C16 mock treatment 1.44608091E8 -1.21E7 -0.32 1.47214323E8 -2.0E7 -0.56 -0.6233 -0.9625 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C17 compound treatment 4.368627E7 -1.13E8 -2.96 4.3514093E7 -1.24E8 -3.49 -4.5577 -0.9966 3187008 PK04_093057 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C18 compound treatment 1.10718561E8 -4.6E7 -1.2 1.26965274E8 -4.03E7 -1.14 -1.6541 -0.9996 3068193 PK04_093058 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C19 compound treatment 8.0585408E7 -7.61E7 -1.99 8.7361065E7 -7.99E7 -2.25 -3.001 -0.9981 3187009 PK04_093059 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C20 compound treatment 1.14530948E8 -4.22E7 -1.1 1.18051755E8 -4.92E7 -1.39 -1.7611 -0.9936 3187010 PK04_093060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C21 compound treatment 1.39235499E8 -1.75E7 -0.46 1.42979249E8 -2.43E7 -0.68 -0.8071 -0.9808 3068197 PK04_093061 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C22 compound treatment 1.48282793E8 -8420000.0 -0.22 1.45405882E8 -2.19E7 -0.62 -0.5913 -0.904 3187011 PK04_093062 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C23 compound treatment 1.69842779E8 1.31E7 0.34 1.74646131E8 7380000.0 0.21 0.3904 0.971 3068199 PK04_093063 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 C24 compound treatment 1.7650362E8 1.98E7 0.52 1.86041918E8 1.88E7 0.53 0.7408 0.9999 3187012 PK04_093064 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCCCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D01 compound treatment 1.81668472E8 2.5E7 0.65 1.74208628E8 6950000.0 0.2 0.6006 0.8803 3187091 PK04_093065 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D02 compound treatment 1.4535248E8 -1.13E7 -0.3 1.4945539E8 -1.78E7 -0.5 -0.5649 -0.9687 3068202 PK04_093066 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D03 compound treatment 1.63567779E8 6870000.0 0.18 1.64183144E8 -3080000.0 -0.09 0.0658 0.3295 3187092 PK04_093067 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D04 compound treatment 5.9490301E7 -9.72E7 -2.54 6.2278668E7 -1.05E8 -2.96 -3.8913 -0.9972 3187093 PK04_093068 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D05 compound treatment 5.6027044E7 -1.01E8 -2.64 8.0726749E7 -8.65E7 -2.44 -3.5878 -0.9992 3068220 PK04_093069 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D06 compound treatment 4.6204709E7 -1.1E8 -2.89 4.624536E7 -1.21E8 -3.41 -4.4567 -0.9966 3187094 PK04_093070 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D07 compound treatment 1.422654E8 -1.44E7 -0.38 1.57724068E8 -9540000.0 -0.27 -0.4572 -0.9861 3068223 PK04_093071 COC(=O)[C@H]1COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D08 compound treatment 5.2083459E7 -1.05E8 -2.74 5.8033479E7 -1.09E8 -3.08 -4.113 -0.9983 3187095 PK04_093072 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D09 compound treatment 5.8266036E7 -9.84E7 -2.58 5.8388582E7 -1.09E8 -3.07 -3.9915 -0.9962 3068225 PK04_093073 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D10 compound treatment 1.35411449E8 -2.13E7 -0.56 1.4410099E8 -2.32E7 -0.65 -0.8556 -0.9969 3187096 PK04_093074 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D11 mock treatment 1.40141748E8 -1.66E7 -0.43 1.56804431E8 -1.05E7 -0.29 -0.5149 -0.9823 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D12 mock treatment 1.49324004E8 -7380000.0 -0.19 1.59451769E8 -7810000.0 -0.22 -0.2921 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D13 compound treatment 5.820484E7 -9.85E7 -2.58 6.6808623E7 -1.0E8 -2.83 -3.8248 -0.9989 3187097 PK04_093075 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D14 compound treatment 1.15519679E8 -4.12E7 -1.08 1.24717178E8 -4.25E7 -1.2 -1.61 -0.9986 3068228 PK04_093076 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D15 mock treatment 1.47257996E8 -9440000.0 -0.25 1.53564126E8 -1.37E7 -0.39 -0.4477 -0.9768 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D16 mock treatment 1.53434729E8 -3260000.0 -0.09 1.6695126E8 -311000.0 -0.01 -0.0666 -0.7755 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D17 compound treatment 1.24944583E8 -3.18E7 -0.83 1.40382454E8 -2.69E7 -0.76 -1.1234 -0.9989 3187098 PK04_093077 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D18 compound treatment 1.44156496E8 -1.25E7 -0.33 1.57734705E8 -9530000.0 -0.27 -0.422 -0.995 3187099 PK04_093078 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D19 compound treatment 1.44049482E8 -1.26E7 -0.33 1.5783709E8 -9430000.0 -0.27 -0.422 -0.994 3068229 PK04_093079 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D20 compound treatment 1.46415462E8 -1.03E7 -0.27 1.59529148E8 -7730000.0 -0.22 -0.3444 -0.9945 3187100 PK04_093080 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D21 compound treatment 1.08521312E8 -4.82E7 -1.26 1.19886132E8 -4.74E7 -1.34 -1.8358 -0.9996 3068232 PK04_093081 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D22 compound treatment 1.52777281E8 -3920000.0 -0.1 1.51724277E8 -1.55E7 -0.44 -0.3822 -0.8499 3187101 PK04_093082 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D23 compound treatment 1.07988339E8 -4.87E7 -1.28 1.0506762E8 -6.22E7 -1.75 -2.141 -0.9878 3187102 PK04_093083 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 D24 compound treatment 1.60005845E8 3310000.0 0.09 1.54402184E8 -1.29E7 -0.36 -0.1951 -0.5235 3068234 PK04_093084 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E01 mock treatment 1.97296857E8 4.06E7 1.06 1.85208876E8 1.79E7 0.51 1.1091 0.9423 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E02 mock treatment 1.79986083E8 2.33E7 0.61 1.6266268E8 -4600000.0 -0.13 0.3394 0.5446 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E03 compound treatment 1.63573982E8 6870000.0 0.18 1.68895692E8 1630000.0 0.05 0.1598 0.8603 3187103 PK04_093085 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E04 compound treatment 6.0540916E7 -9.62E7 -2.52 5.9442117E7 -1.08E8 -3.04 -3.9284 -0.9956 3187104 PK04_093086 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E05 compound treatment 1.46937568E8 -9760000.0 -0.26 1.55643839E8 -1.16E7 -0.33 -0.4122 -0.9925 3068237 PK04_093087 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E06 compound treatment 1.41202755E8 -1.55E7 -0.41 1.57118474E8 -1.01E7 -0.29 -0.489 -0.9853 3187105 PK04_093088 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E07 compound treatment 4.3333992E7 -1.13E8 -2.97 4.5104509E7 -1.22E8 -3.44 -4.5325 -0.9973 3068240 PK04_093089 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E08 compound treatment 6.0559368E7 -9.61E7 -2.52 6.9438168E7 -9.78E7 -2.76 -3.7288 -0.999 3187106 PK04_093090 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E09 mock treatment 1.42778799E8 -1.39E7 -0.36 1.6012977E8 -7130000.0 -0.2 -0.3998 -0.9607 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E10 mock treatment 1.40259052E8 -1.64E7 -0.43 1.58340041E8 -8920000.0 -0.25 -0.4821 -0.9672 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E11 compound treatment 1.19992328E8 -3.67E7 -0.96 1.3719903E8 -3.01E7 -0.85 -1.2785 -0.998 3068242 PK04_093091 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E12 compound treatment 1.06980093E8 -4.97E7 -1.3 1.16942371E8 -5.03E7 -1.42 -1.923 -0.9991 3187107 PK04_093092 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E13 compound treatment 1.17351539E8 -3.93E7 -1.03 1.15970173E8 -5.13E7 -1.45 -1.7504 -0.9862 3068264 PK04_093093 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E14 compound treatment 1.07712052E8 -4.9E7 -1.28 1.25191981E8 -4.21E7 -1.19 -1.7451 -0.9992 3187108 PK04_093094 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E15 compound treatment 7.1567687E7 -8.51E7 -2.23 7.629816E7 -9.1E7 -2.56 -3.3884 -0.9976 3187109 PK04_093095 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E16 compound treatment 1.0570619E8 -5.1E7 -1.33 1.2769718E8 -3.96E7 -1.11 -1.7323 -0.996 3068267 PK04_093096 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E17 mock treatment 1.54359617E8 -2340000.0 -0.06 1.70906034E8 3640000.0 0.1 0.0293 0.2451 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E18 mock treatment 1.61719716E8 5020000.0 0.13 1.72277465E8 5020000.0 0.14 0.1929 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E19 compound treatment 1.63167217E8 6470000.0 0.17 1.75539895E8 8280000.0 0.23 0.2847 0.9876 3187110 PK04_093097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E20 compound treatment 1.4245722E8 -1.42E7 -0.37 1.57893345E8 -9370000.0 -0.26 -0.4503 -0.9857 3187111 PK04_093098 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E21 compound treatment 1.50179796E8 -6520000.0 -0.17 1.58795203E8 -8470000.0 -0.24 -0.2894 -0.9865 3068269 PK04_093099 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E22 compound treatment 1.43687977E8 -1.3E7 -0.34 1.48735454E8 -1.85E7 -0.52 -0.61 -0.9786 3187184 PK04_093100 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E23 compound treatment 1.45801479E8 -1.09E7 -0.29 1.51595496E8 -1.57E7 -0.44 -0.5139 -0.9777 3068272 PK04_093101 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 E24 compound treatment 8.108125E7 -7.56E7 -1.98 8.024114E7 -8.7E7 -2.45 -3.1337 -0.9944 3187185 PK04_093102 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F01 mock treatment 1.9324663E8 3.65E7 0.96 1.88001958E8 2.07E7 0.58 1.0898 0.972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F02 mock treatment 1.78668601E8 2.2E7 0.58 1.82192046E8 1.49E7 0.42 0.7041 0.9882 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F03 compound treatment 7.0531412E7 -8.62E7 -2.26 7.1532128E7 -9.57E7 -2.7 -3.5025 -0.996 3068274 PK04_093103 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F04 compound treatment 6.8246869E7 -8.85E7 -2.32 7.238034E7 -9.49E7 -2.67 -3.5279 -0.9974 3187186 PK04_093104 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F05 compound treatment 9.5339614E7 -6.14E7 -1.61 9.6737302E7 -7.05E7 -1.99 -2.5411 -0.9944 3068276 PK04_093105 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F06 compound treatment 1.11250358E8 -4.54E7 -1.19 1.22858817E8 -4.44E7 -1.25 -1.7261 -0.9997 3187187 PK04_093106 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F07 compound treatment 1.00538372E8 -5.62E7 -1.47 1.14723033E8 -5.25E7 -1.48 -2.0865 -1.0 3187188 PK04_093107 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F08 compound treatment 8.2253464E7 -7.44E7 -1.95 9.0444812E7 -7.68E7 -2.16 -2.9087 -0.9986 3068278 PK04_093108 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F09 mock treatment 1.4933573E8 -7360000.0 -0.19 1.65907651E8 -1350000.0 -0.04 -0.1633 -0.831 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F10 mock treatment 1.39430414E8 -1.73E7 -0.45 1.58107693E8 -9150000.0 -0.26 -0.5021 -0.9646 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F11 compound treatment 8.5470587E7 -7.12E7 -1.86 1.08177057E8 -5.91E7 -1.67 -2.4958 -0.9984 3187189 PK04_093109 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F12 compound treatment 1.3986513E8 -1.68E7 -0.44 1.55572541E8 -1.17E7 -0.33 -0.5445 -0.9897 3068280 PK04_093110 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F13 compound treatment 8.5658339E7 -7.1E7 -1.86 9.791475E7 -6.93E7 -1.95 -2.6968 -0.9997 3187190 PK04_093111 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F14 compound treatment 9.1992567E7 -6.47E7 -1.69 9.6230734E7 -7.1E7 -2.0 -2.6131 -0.9965 3187191 PK04_093112 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F15 compound treatment 5.1060202E7 -1.06E8 -2.77 6.1125276E7 -1.06E8 -2.99 -4.0703 -0.9992 3068282 PK04_093113 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F16 compound treatment 7.2315552E7 -8.44E7 -2.21 8.6369644E7 -8.09E7 -2.28 -3.1738 -0.9999 3187192 PK04_093114 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F17 mock treatment 1.5432109E8 -2380000.0 -0.06 1.67299932E8 37800.0 0.0 -0.0433 -0.6949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F18 mock treatment 1.60054205E8 3350000.0 0.09 1.73358007E8 6100000.0 0.17 0.1836 0.9515 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F19 compound treatment 4.9208747E7 -1.07E8 -2.81 5.1934826E7 -1.15E8 -3.25 -4.2877 -0.9974 3187193 PK04_093115 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F20 compound treatment 1.67246401E8 1.05E7 0.28 1.76783089E8 9520000.0 0.27 0.3849 0.9999 3068312 PK04_093116 NC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F21 compound treatment 1.34315623E8 -2.24E7 -0.59 1.44737645E8 -2.25E7 -0.63 -0.8632 -0.9992 3068314 PK04_093117 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F22 compound treatment 1.63930229E8 7230000.0 0.19 1.64881328E8 -2380000.0 -0.07 0.0864 0.4302 3187194 PK04_093118 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F23 compound treatment 9.4555231E7 -6.21E7 -1.63 9.5844237E7 -7.14E7 -2.01 -2.5734 -0.9944 3187195 PK04_093119 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 F24 compound treatment 2.02710439E8 4.6E7 1.2 2.03550295E8 3.63E7 1.02 1.5748 0.9967 3068317 PK04_093120 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G01 compound treatment 1.87124583E8 3.04E7 0.8 1.87579143E8 2.03E7 0.57 0.968 0.9869 3187196 PK04_093121 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G02 compound treatment 1.79887829E8 2.32E7 0.61 1.66542779E8 -719000.0 -0.02 0.4149 0.6831 3068319 PK04_093122 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCCCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G03 mock treatment 1.67670692E8 1.1E7 0.29 1.67435138E8 173000.0 0.0 0.2065 0.719 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G04 mock treatment 1.58072913E8 1370000.0 0.04 1.68099065E8 837000.0 0.02 0.0421 0.9791 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G05 compound treatment 1.42813131E8 -1.39E7 -0.36 1.52196928E8 -1.51E7 -0.42 -0.5572 -0.997 3187197 PK04_093123 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G06 compound treatment 9.2221073E7 -6.45E7 -1.69 1.01792991E8 -6.55E7 -1.84 -2.4981 -0.999 3187198 PK04_093124 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G07 compound treatment 1.33385919E8 -2.33E7 -0.61 1.49115302E8 -1.81E7 -0.51 -0.7931 -0.9961 3068323 PK04_093125 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G08 compound treatment 1.18196412E8 -3.85E7 -1.01 1.36296396E8 -3.1E7 -0.87 -1.3297 -0.9974 3187199 PK04_093126 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G09 compound treatment 1.43825075E8 -1.29E7 -0.34 1.65573761E8 -1690000.0 -0.05 -0.2719 -0.799 3068325 PK04_093127 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G10 compound treatment 1.39681485E8 -1.7E7 -0.45 1.52333954E8 -1.49E7 -0.42 -0.6125 -0.9996 3187200 PK04_093128 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G11 compound treatment 1.23647683E8 -3.31E7 -0.87 1.4108878E8 -2.62E7 -0.74 -1.1333 -0.9968 3187201 PK04_093129 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G12 compound treatment 5.5688891E7 -1.01E8 -2.64 5.8486213E7 -1.09E8 -3.07 -4.0372 -0.9973 3068327 PK04_093130 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G13 compound treatment 4.4742922E7 -1.12E8 -2.93 4.8121613E7 -1.19E8 -3.36 -4.4463 -0.9977 3187202 PK04_093131 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G14 compound treatment 1.50362307E8 -6340000.0 -0.17 1.68698755E8 1440000.0 0.04 -0.0887 -0.5193 3187203 PK04_093132 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G15 compound treatment 1.43487057E8 -1.32E7 -0.35 1.63282506E8 -3980000.0 -0.11 -0.3239 -0.8907 3068330 PK04_093133 COC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G16 compound treatment 1.13256085E8 -4.34E7 -1.14 1.16744054E8 -5.05E7 -1.42 -1.8108 -0.9938 3068332 PK04_093134 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G17 compound treatment 1.45941501E8 -1.08E7 -0.28 1.538653E8 -1.34E7 -0.38 -0.4661 -0.9896 3187278 PK04_093135 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G18 compound treatment 1.46958518E8 -9740000.0 -0.25 1.53110539E8 -1.42E7 -0.4 -0.4623 -0.9766 3187279 PK04_093136 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G19 mock treatment 1.62824394E8 6130000.0 0.16 1.78475796E8 1.12E7 0.32 0.3368 0.9505 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G20 mock treatment 1.62518672E8 5820000.0 0.15 1.81064141E8 1.38E7 0.39 0.3827 0.9163 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G21 compound treatment 1.77480245E8 2.08E7 0.54 1.81030654E8 1.38E7 0.39 0.659 0.9863 3187280 PK04_093137 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G22 compound treatment 1.36590995E8 -2.01E7 -0.53 1.34995451E8 -3.23E7 -0.91 -1.0152 -0.9662 3068361 PK04_093138 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G23 compound treatment 1.72531677E8 1.58E7 0.41 1.68879208E8 1620000.0 0.05 0.3253 0.7802 3187281 PK04_093139 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 G24 compound treatment 1.30171683E8 -2.65E7 -0.69 1.30070604E8 -3.72E7 -1.05 -1.2321 -0.98 3187282 PK04_093140 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H01 compound treatment 6.3508533E7 -9.32E7 -2.44 6.900484E7 -9.83E7 -2.77 -3.6829 -0.998 3068365 PK04_093141 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H02 compound treatment 7.6915321E7 -7.98E7 -2.09 7.2379516E7 -9.49E7 -2.67 -3.3675 -0.9925 3187283 PK04_093142 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H03 mock treatment 1.62759648E8 6060000.0 0.16 1.75838962E8 8580000.0 0.24 0.2831 0.9791 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H04 mock treatment 1.51238877E8 -5460000.0 -0.14 1.67083598E8 -179000.0 -0.01 -0.1046 -0.7315 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H05 compound treatment 7.8197272E7 -7.85E7 -2.05 9.0813348E7 -7.64E7 -2.15 -2.9764 -0.9997 3068368 PK04_093143 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H06 compound treatment 1.4402628E8 -1.27E7 -0.33 1.59673499E8 -7590000.0 -0.21 -0.3858 -0.9774 3187284 PK04_093144 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H07 compound treatment 7.3169332E7 -8.35E7 -2.19 8.5619313E7 -8.16E7 -2.3 -3.173 -0.9997 3187285 PK04_093145 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H08 compound treatment 1.36340359E8 -2.04E7 -0.53 1.59570548E8 -7690000.0 -0.22 -0.5301 -0.9214 3068370 PK04_093146 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H09 compound treatment 5.969664E7 -9.7E7 -2.54 6.4944731E7 -1.02E8 -2.88 -3.8343 -0.998 3187286 PK04_093147 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H10 compound treatment 9.574251E7 -6.1E7 -1.6 1.07546632E8 -5.97E7 -1.68 -2.3182 -0.9996 3187287 PK04_093148 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H11 compound treatment 1.03411565E8 -5.33E7 -1.39 1.15030711E8 -5.22E7 -1.47 -2.0271 -0.9996 3068373 PK04_093149 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H12 compound treatment 1.26834449E8 -2.99E7 -0.78 1.47273786E8 -2.0E7 -0.56 -0.9511 -0.9871 3187288 PK04_093150 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCc3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H13 compound treatment 6.6632661E7 -9.01E7 -2.36 6.8546885E7 -9.87E7 -2.78 -3.6342 -0.9966 3187289 PK04_093151 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H14 compound treatment 4.7609023E7 -1.09E8 -2.86 5.0342326E7 -1.17E8 -3.29 -4.349 -0.9975 3068375 PK04_093152 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H15 compound treatment 6.4443111E7 -9.23E7 -2.41 7.0248706E7 -9.7E7 -2.73 -3.6408 -0.9981 3187290 PK04_093153 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H16 compound treatment 1.4261733E8 -1.41E7 -0.37 1.54126307E8 -1.31E7 -0.37 -0.5224 -1.0 3187291 PK04_093154 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H17 compound treatment 1.33703673E8 -2.3E7 -0.6 1.43520759E8 -2.37E7 -0.67 -0.8987 -0.9986 3068378 PK04_093155 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H18 compound treatment 1.55461453E8 -1240000.0 -0.03 1.70964372E8 3700000.0 0.1 0.0509 0.4656 3187292 PK04_093156 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H19 mock treatment 1.59854108E8 3150000.0 0.08 1.74045142E8 6780000.0 0.19 0.1936 0.9296 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H20 mock treatment 1.59605164E8 2910000.0 0.08 1.73086869E8 5820000.0 0.16 0.1699 0.9389 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H21 compound treatment 1.01281893E8 -5.54E7 -1.45 6.9663196E7 -9.76E7 -2.75 -2.9706 -0.9553 3187293 PK04_093157 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H22 compound treatment 1.24740853E8 -3.2E7 -0.84 1.18802217E8 -4.85E7 -1.37 -1.5572 -0.9723 3068380 PK04_093158 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H23 compound treatment 8.054535E7 -7.62E7 -1.99 7.7208587E7 -9.01E7 -2.54 -3.2041 -0.9929 3068402 PK04_093159 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 H24 compound treatment 1.62139589E8 5440000.0 0.14 1.35836525E8 -3.14E7 -0.89 -0.5255 -0.5859 3187294 PK04_093160 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I01 compound treatment 1.83791289E8 2.71E7 0.71 1.70735981E8 3470000.0 0.1 0.5707 0.7972 3068406 PK04_093161 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I02 compound treatment 8.0538576E7 -7.62E7 -1.99 8.3067199E7 -8.42E7 -2.37 -3.0874 -0.9963 3187295 PK04_093162 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I03 compound treatment 1.58509986E8 1810000.0 0.05 1.57195765E8 -1.01E7 -0.28 -0.1671 -0.5809 3068409 PK04_093163 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I04 compound treatment 1.56867683E8 168000.0 0.0 1.68605287E8 1340000.0 0.04 0.0299 0.7842 3187296 PK04_093164 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I05 mock treatment 1.52098878E8 -4600000.0 -0.12 1.69060393E8 1800000.0 0.05 -0.0493 -0.3775 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I06 mock treatment 1.48682988E8 -8020000.0 -0.21 1.68771043E8 1510000.0 0.04 -0.1183 -0.5526 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I07 compound treatment 1.34238863E8 -2.25E7 -0.59 1.41050828E8 -2.62E7 -0.74 -0.938 -0.9936 3187297 PK04_093165 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I08 compound treatment 1.52338981E8 -4360000.0 -0.11 1.69513067E8 2250000.0 0.06 -0.0359 -0.2746 3068413 PK04_093166 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I09 compound treatment 1.44427801E8 -1.23E7 -0.32 1.64569917E8 -2690000.0 -0.08 -0.2808 -0.8507 3187298 PK04_093167 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I10 compound treatment 1.38227945E8 -1.85E7 -0.48 1.50221764E8 -1.7E7 -0.48 -0.6815 -1.0 3187366 PK04_093168 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I11 compound treatment 1.49710717E8 -6990000.0 -0.18 1.71604179E8 4340000.0 0.12 -0.0428 -0.1946 3068416 PK04_093169 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I12 compound treatment 1.1391226E8 -4.28E7 -1.12 1.00980868E8 -6.63E7 -1.87 -2.1127 -0.9701 3187367 PK04_093170 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I13 compound treatment 1.34926805E8 -2.18E7 -0.57 1.53307041E8 -1.4E7 -0.39 -0.6811 -0.9836 3068419 PK04_093171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I14 compound treatment 1.17290848E8 -3.94E7 -1.03 1.23484853E8 -4.38E7 -1.23 -1.6018 -0.996 3187368 PK04_093172 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I15 compound treatment 1.42171006E8 -1.45E7 -0.38 1.65772259E8 -1490000.0 -0.04 -0.2986 -0.7804 3068421 PK04_093173 COC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I16 compound treatment 1.14571953E8 -4.21E7 -1.1 1.21975229E8 -4.53E7 -1.28 -1.6822 -0.9974 3187369 PK04_093174 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I17 compound treatment 1.50547556E8 -6150000.0 -0.16 1.73200033E8 5940000.0 0.17 0.0045 0.0192 3068423 PK04_093175 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I18 compound treatment 1.59207501E8 2510000.0 0.07 1.72474761E8 5210000.0 0.15 0.1503 0.9341 3187370 PK04_093176 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I19 compound treatment 1.55163522E8 -1540000.0 -0.04 1.71118398E8 3860000.0 0.11 0.0484 0.4178 3187371 PK04_093177 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I20 compound treatment 1.18444871E8 -3.83E7 -1.0 1.30205422E8 -3.71E7 -1.04 -1.4465 -0.9998 3068425 PK04_093178 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I21 mock treatment 1.69169909E8 1.25E7 0.33 1.7546468E8 8200000.0 0.23 0.3943 0.9857 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I22 mock treatment 1.72335451E8 1.56E7 0.41 1.74915705E8 7650000.0 0.22 0.4419 0.9552 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I23 compound treatment 1.74085767E8 1.74E7 0.46 1.73205025E8 5940000.0 0.17 0.4402 0.9078 3187372 PK04_093179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 I24 compound treatment 1.94781981E8 3.81E7 1.0 2.03120863E8 3.59E7 1.01 1.4194 1.0 3068456 PK04_093180 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J01 compound treatment 4.5679978E7 -1.11E8 -2.91 4.5298048E7 -1.22E8 -3.44 -4.4853 -0.9965 3187373 PK04_093181 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J02 compound treatment 5.9826879E7 -9.69E7 -2.54 5.5878093E7 -1.11E8 -3.14 -4.0126 -0.9944 3187374 PK04_093182 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J03 compound treatment 6.7475843E7 -8.92E7 -2.34 1.00422841E8 -6.68E7 -1.88 -2.9834 -0.9943 3068460 PK04_093183 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J04 compound treatment 1.42363107E8 -1.43E7 -0.38 1.66696436E8 -566000.0 -0.02 -0.2766 -0.7365 3187375 PK04_093184 COCCCNC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J05 mock treatment 1.45611771E8 -1.11E7 -0.29 1.63962591E8 -3300000.0 -0.09 -0.271 -0.8891 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J06 mock treatment 1.48884801E8 -7810000.0 -0.2 1.60353667E8 -6910000.0 -0.19 -0.2823 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J07 compound treatment 5.7720865E7 -9.9E7 -2.59 8.3741996E7 -8.35E7 -2.35 -3.4963 -0.9989 3187376 PK04_093185 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J08 compound treatment 7.3718669E7 -8.3E7 -2.17 8.4956341E7 -8.23E7 -2.32 -3.176 -0.9995 3068463 PK04_093186 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J09 compound treatment 1.21424032E8 -3.53E7 -0.92 1.34027836E8 -3.32E7 -0.94 -1.3152 -1.0 3187377 PK04_093187 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J10 compound treatment 1.29422033E8 -2.73E7 -0.71 1.50252377E8 -1.7E7 -0.48 -0.8438 -0.9812 3068465 PK04_093188 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J11 compound treatment 5.7285373E7 -9.94E7 -2.6 6.8984365E7 -9.83E7 -2.77 -3.7985 -0.9995 3187378 PK04_093189 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J12 compound treatment 1.38857046E8 -1.78E7 -0.47 1.56533098E8 -1.07E7 -0.3 -0.544 -0.9778 3068467 PK04_093190 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J13 compound treatment 4.0914988E7 -1.16E8 -3.03 5.325221E7 -1.14E8 -3.21 -4.415 -0.9996 3187379 PK04_093191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J14 compound treatment 4.0863754E7 -1.16E8 -3.03 4.1088082E7 -1.26E8 -3.56 -4.6583 -0.9969 3187380 PK04_093192 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J15 compound treatment 1.14757476E8 -4.19E7 -1.1 1.06307117E8 -6.1E7 -1.72 -1.991 -0.9766 3068470 PK04_093193 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J16 compound treatment 1.39030737E8 -1.77E7 -0.46 1.5155952E8 -1.57E7 -0.44 -0.6399 -0.9998 3187381 PK04_093194 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J17 compound treatment 1.01214949E8 -5.55E7 -1.45 1.06071527E8 -6.12E7 -1.72 -2.2463 -0.9964 3187382 PK04_093195 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J18 compound treatment 7.846516E7 -7.82E7 -2.05 8.8958172E7 -7.83E7 -2.21 -3.0084 -0.9993 3068473 PK04_093196 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J19 compound treatment 1.17074496E8 -3.96E7 -1.04 1.31738702E8 -3.55E7 -1.0 -1.4413 -0.9998 3187383 PK04_093197 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J20 compound treatment 1.00942354E8 -5.58E7 -1.46 1.12653327E8 -5.46E7 -1.54 -2.1202 -0.9996 3068475 PK04_093198 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J21 mock treatment 1.62964927E8 6270000.0 0.16 1.73916051E8 6650000.0 0.19 0.2486 0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J22 mock treatment 1.77737313E8 2.1E7 0.55 1.80934888E8 1.37E7 0.39 0.6619 0.9847 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J23 compound treatment 1.51308575E8 -5390000.0 -0.14 1.5292391E8 -1.43E7 -0.4 -0.3855 -0.9007 3187384 PK04_093199 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 J24 compound treatment 8.0908269E7 -7.58E7 -1.98 6.2155593E7 -1.05E8 -2.96 -3.4973 -0.981 3068477 PK04_093200 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K01 compound treatment 2.20483194E8 6.38E7 1.67 1.79751514E8 1.25E7 0.35 1.4295 0.8378 3187385 PK04_093201 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K02 compound treatment 1.09599422E8 -4.71E7 -1.23 9.9389267E7 -6.79E7 -1.91 -2.2243 -0.9774 3187386 PK04_093202 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K03 compound treatment 1.50343389E8 -6360000.0 -0.17 1.50441569E8 -1.68E7 -0.47 -0.4528 -0.9014 3187447 PK04_093203 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K04 compound treatment 8.517003E7 -7.15E7 -1.87 1.01668287E8 -6.56E7 -1.85 -2.6311 -1.0 3068500 PK04_093204 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K05 compound treatment 7.7137949E7 -7.96E7 -2.08 1.08860656E8 -5.84E7 -1.65 -2.6364 -0.9932 3187448 PK04_093205 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K06 compound treatment 8.1475088E7 -7.52E7 -1.97 8.4798112E7 -8.25E7 -2.32 -3.0356 -0.9966 3187449 PK04_093206 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K07 mock treatment 1.45799584E8 -1.09E7 -0.29 1.60319823E8 -6940000.0 -0.2 -0.3401 -0.9831 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K08 mock treatment 1.50426667E8 -6270000.0 -0.16 1.68722745E8 1460000.0 0.04 -0.087 -0.514 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K09 compound treatment 1.54924009E8 -1780000.0 -0.05 1.71121719E8 3860000.0 0.11 0.044 0.3724 3068503 PK04_093207 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K10 compound treatment 1.24426166E8 -3.23E7 -0.84 1.36924709E8 -3.03E7 -0.85 -1.2019 -1.0 3187450 PK04_093208 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K11 compound treatment 8.3255001E7 -7.34E7 -1.92 8.2733705E7 -8.45E7 -2.38 -3.0438 -0.9944 3068506 PK04_093209 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K12 compound treatment 1.15087336E8 -4.16E7 -1.09 1.22597096E8 -4.47E7 -1.26 -1.6602 -0.9974 3187451 PK04_093210 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K13 compound treatment 1.42724627E8 -1.4E7 -0.37 1.64480225E8 -2780000.0 -0.08 -0.3141 -0.8396 3187452 PK04_093211 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K14 compound treatment 1.27777111E8 -2.89E7 -0.76 1.34601012E8 -3.27E7 -0.92 -1.1862 -0.9953 3068509 PK04_093212 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K15 mock treatment 1.41941917E8 -1.48E7 -0.39 1.61930894E8 -5330000.0 -0.15 -0.3794 -0.9153 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K16 mock treatment 1.5612546E8 -574000.0 -0.02 1.70758097E8 3500000.0 0.1 0.059 0.5924 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K17 compound treatment 1.38503084E8 -1.82E7 -0.48 1.61158037E8 -6100000.0 -0.17 -0.4584 -0.9052 3187453 PK04_093213 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K18 compound treatment 1.44151461E8 -1.25E7 -0.33 1.54300243E8 -1.3E7 -0.37 -0.4905 -0.9986 3187454 PK04_093214 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K19 compound treatment 5.0596884E7 -1.06E8 -2.78 4.9641861E7 -1.18E8 -3.31 -4.3077 -0.9961 3068511 PK04_093215 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K20 compound treatment 1.23691228E8 -3.3E7 -0.86 1.23690549E8 -4.36E7 -1.23 -1.4792 -0.9852 3187455 PK04_093216 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K21 compound treatment 1.60341421E8 3640000.0 0.1 1.63922812E8 -3340000.0 -0.09 9.0E-4 0.0065 3068513 PK04_093217 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K22 compound treatment 1.33822536E8 -2.29E7 -0.6 8.2051166E7 -8.52E7 -2.4 -2.1214 -0.8572 3187456 PK04_093218 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K23 mock treatment 1.78124167E8 2.14E7 0.56 1.70517225E8 3260000.0 0.09 0.4614 0.812 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 K24 mock treatment 1.99866642E8 4.32E7 1.13 2.09046569E8 4.18E7 1.18 1.6316 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L01 compound treatment 6.742541E7 -8.93E7 -2.34 6.2969406E7 -1.04E8 -2.94 -3.7306 -0.9936 3187457 PK04_093219 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L02 compound treatment 6.3051133E7 -9.36E7 -2.45 6.5276718E7 -1.02E8 -2.87 -3.7656 -0.9969 3068516 PK04_093220 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L03 compound treatment 7.6507033E7 -8.02E7 -2.1 7.9909767E7 -8.74E7 -2.46 -3.225 -0.9969 3187458 PK04_093221 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L04 compound treatment 1.012091E8 -5.55E7 -1.45 1.19576273E8 -4.77E7 -1.34 -1.9773 -0.9992 3187459 PK04_093222 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L05 compound treatment 8.7502496E7 -6.92E7 -1.81 9.2682097E7 -7.46E7 -2.1 -2.7669 -0.9973 3068518 PK04_093223 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L06 compound treatment 9.387379E7 -6.28E7 -1.64 9.9436553E7 -6.78E7 -1.91 -2.5144 -0.9972 3187460 PK04_093224 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L07 mock treatment 1.45472273E8 -1.12E7 -0.29 1.69144986E8 1880000.0 0.05 -0.1703 -0.5702 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L08 mock treatment 1.43757157E8 -1.29E7 -0.34 1.66924E8 -338000.0 -0.01 -0.2463 -0.7267 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L09 compound treatment 1.15087445E8 -4.16E7 -1.09 1.22636055E8 -4.46E7 -1.26 -1.6595 -0.9974 3068520 PK04_093225 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L10 compound treatment 1.50519877E8 -6180000.0 -0.16 1.73193566E8 5930000.0 0.17 0.0038 0.0164 3187461 PK04_093226 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L11 compound treatment 5.9218763E7 -9.75E7 -2.55 6.3968742E7 -1.03E8 -2.91 -3.8626 -0.9978 3187462 PK04_093227 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L12 compound treatment 1.40853836E8 -1.58E7 -0.41 1.50659308E8 -1.66E7 -0.47 -0.6241 -0.9982 3187463 PK04_093228 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L13 compound treatment 5.8329886E7 -9.84E7 -2.57 6.0589249E7 -1.07E8 -3.01 -3.9464 -0.997 3068543 PK04_093229 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L14 compound treatment 4.7729395E7 -1.09E8 -2.85 4.7948687E7 -1.19E8 -3.36 -4.3945 -0.9967 3187464 PK04_093230 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L15 mock treatment 1.57170375E8 471000.0 0.01 1.64156296E8 -3110000.0 -0.09 -0.0532 -0.6015 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L16 mock treatment 1.39537315E8 -1.72E7 -0.45 1.72148424E8 4890000.0 0.14 -0.2203 -0.4688 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L17 compound treatment 9.1911942E7 -6.48E7 -1.7 9.2327663E7 -7.49E7 -2.11 -2.6924 -0.9941 3068545 PK04_093231 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L18 compound treatment 6.619814E7 -9.05E7 -2.37 6.9888322E7 -9.74E7 -2.74 -3.6155 -0.9973 3187465 PK04_093232 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L19 compound treatment 9.5272847E7 -6.14E7 -1.61 9.7586965E7 -6.97E7 -1.96 -2.5254 -0.9951 3187466 PK04_093233 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L20 compound treatment 1.53718976E8 -2980000.0 -0.08 1.63007453E8 -4250000.0 -0.12 -0.1399 -0.9783 3068547 PK04_093234 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L21 compound treatment 1.12385344E8 -4.43E7 -1.16 1.05632585E8 -6.16E7 -1.74 -2.0483 -0.9807 3187467 PK04_093235 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L22 compound treatment 7.1210534E7 -8.55E7 -2.24 6.3101086E7 -1.04E8 -2.94 -3.658 -0.991 3068549 PK04_093236 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L23 mock treatment 1.78688458E8 2.2E7 0.58 1.76213181E8 8950000.0 0.25 0.5854 0.9315 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 L24 mock treatment 1.97390443E8 4.07E7 1.07 2.02793913E8 3.55E7 1.0 1.4612 0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M01 compound treatment 1.12444353E8 -4.43E7 -1.16 1.07051563E8 -6.02E7 -1.7 -2.0189 -0.9827 3187528 PK04_093237 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M02 compound treatment 1.15066445E8 -4.16E7 -1.09 1.06511199E8 -6.08E7 -1.71 -1.9812 -0.9762 3187529 PK04_093238 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M03 compound treatment 1.6291469E8 6220000.0 0.16 1.62813145E8 -4450000.0 -0.13 0.0264 0.1285 3068551 PK04_093239 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M04 compound treatment 1.42541199E8 -1.42E7 -0.37 1.47638504E8 -1.96E7 -0.55 -0.6531 -0.9811 3187530 PK04_093240 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M05 compound treatment 1.5979444E8 3100000.0 0.08 1.70962031E8 3700000.0 0.1 0.131 0.9922 3068553 PK04_093241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M06 compound treatment 1.39980206E8 -1.67E7 -0.44 1.4659815E8 -2.07E7 -0.58 -0.7212 -0.9901 3187531 PK04_093242 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M07 compound treatment 1.52723113E8 -3980000.0 -0.1 1.62345356E8 -4920000.0 -0.14 -0.1716 -0.9901 3187532 PK04_093243 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M08 compound treatment 8.7993847E7 -6.87E7 -1.8 8.431878E7 -8.29E7 -2.34 -2.9245 -0.9916 3068555 PK04_093244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M09 mock treatment 1.5356905E8 -3130000.0 -0.08 1.81368582E8 1.41E7 0.4 0.2232 0.5498 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M10 mock treatment 1.46033678E8 -1.07E7 -0.28 1.61136556E8 -6130000.0 -0.17 -0.3195 -0.9733 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M11 compound treatment 1.24275028E8 -3.24E7 -0.85 1.32687391E8 -3.46E7 -0.97 -1.2891 -0.9976 3187533 PK04_093245 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M12 compound treatment 4.8680126E7 -1.08E8 -2.83 4.9601598E7 -1.18E8 -3.32 -4.344 -0.9969 3187534 PK04_093246 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M13 mock treatment 1.35151222E8 -2.15E7 -0.56 1.59304276E8 -7960000.0 -0.22 -0.5574 -0.9183 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M14 mock treatment 1.35233759E8 -2.15E7 -0.56 1.52461478E8 -1.48E7 -0.42 -0.6922 -0.9892 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M15 compound treatment 1.27514327E8 -2.92E7 -0.76 1.46012412E8 -2.12E7 -0.6 -0.9636 -0.9927 3068558 PK04_093247 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M16 compound treatment 1.48314526E8 -8380000.0 -0.22 1.59006957E8 -8260000.0 -0.23 -0.3197 -0.9996 3187535 PK04_093248 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M17 compound treatment 1.58319816E8 1620000.0 0.04 1.72675176E8 5410000.0 0.15 0.1379 0.8707 3068560 PK04_093249 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M18 compound treatment 1.20938393E8 -3.58E7 -0.94 1.1406162E8 -5.32E7 -1.5 -1.722 -0.9743 3187536 PK04_093250 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M19 compound treatment 1.59146619E8 2450000.0 0.06 1.73459552E8 6200000.0 0.17 0.1688 0.9074 3187537 PK04_093251 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M20 compound treatment 1.54006784E8 -2690000.0 -0.07 1.59398499E8 -7860000.0 -0.22 -0.2065 -0.8882 3068562 PK04_093252 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCOCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M21 compound treatment 1.79647956E8 2.29E7 0.6 1.87812447E8 2.06E7 0.58 0.8343 0.9998 3068586 PK04_093253 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M22 compound treatment 1.67579514E8 1.09E7 0.28 1.6115319E8 -6110000.0 -0.17 0.0797 0.2394 3187538 PK04_093254 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M23 compound treatment 3.9169509E7 -1.18E8 -3.08 4.4067562E7 -1.23E8 -3.47 -4.6303 -0.9982 3068589 PK04_093255 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 M24 compound treatment 1.07255908E8 -4.94E7 -1.29 9.3281199E7 -7.4E7 -2.08 -2.3894 -0.9737 3187539 PK04_093256 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N01 compound treatment 6.7003365E7 -8.97E7 -2.35 6.3834103E7 -1.03E8 -2.91 -3.7212 -0.9943 3187540 PK04_093257 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N02 compound treatment 1.46295359E8 -1.04E7 -0.27 1.48725522E8 -1.85E7 -0.52 -0.5619 -0.9539 3187541 PK04_093258 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N03 compound treatment 5.42397E7 -1.02E8 -2.68 5.3586379E7 -1.14E8 -3.2 -4.1617 -0.9961 3068594 PK04_093259 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CC=C)C3=O)[C@@H](O2)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N04 compound treatment 1.66655048E8 9960000.0 0.26 1.64933291E8 -2330000.0 -0.07 0.1379 0.513 3187542 PK04_093260 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N05 compound treatment 1.22953723E8 -3.37E7 -0.88 1.22654848E8 -4.46E7 -1.26 -1.5135 -0.9851 3068597 PK04_093261 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N06 compound treatment 1.48140863E8 -8560000.0 -0.22 1.55771304E8 -1.15E7 -0.32 -0.3874 -0.9838 3187543 PK04_093262 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N07 compound treatment 9.3923111E7 -6.28E7 -1.64 9.2331412E7 -7.49E7 -2.11 -2.6551 -0.9923 3187544 PK04_093263 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CC=C)C3=O)[C@H](O2)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N08 compound treatment 5.7990214E7 -9.87E7 -2.58 5.1810964E7 -1.15E8 -3.25 -4.1276 -0.9935 3068600 PK04_093264 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N09 mock treatment 1.49304417E8 -7390000.0 -0.19 1.59639838E8 -7620000.0 -0.21 -0.2888 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N10 mock treatment 1.401234E8 -1.66E7 -0.43 1.62734706E8 -4530000.0 -0.13 -0.397 -0.8779 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N11 compound treatment 5.7775744E7 -9.89E7 -2.59 5.7174759E7 -1.1E8 -3.1 -4.0247 -0.996 3187545 PK04_093265 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N12 compound treatment 1.41316451E8 -1.54E7 -0.4 1.53303312E8 -1.4E7 -0.39 -0.5629 -0.9999 3187546 PK04_093266 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N13 mock treatment 1.27133768E8 -2.96E7 -0.77 1.28757895E8 -3.85E7 -1.09 -1.3145 -0.9863 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N14 mock treatment 1.33672234E8 -2.3E7 -0.6 1.51095542E8 -1.62E7 -0.46 -0.7484 -0.9905 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N15 compound treatment 6.6264299E7 -9.04E7 -2.37 5.5647916E7 -1.12E8 -3.15 -3.898 -0.9902 3068603 PK04_093267 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N16 compound treatment 1.481749E8 -8520000.0 -0.22 1.66389152E8 -873000.0 -0.02 -0.1752 -0.7803 3187547 PK04_093268 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N17 compound treatment 5.9908521E7 -9.68E7 -2.53 5.0505965E7 -1.17E8 -3.29 -4.1181 -0.9917 3068605 PK04_093269 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N18 compound treatment 7.2108898E7 -8.46E7 -2.21 6.9044978E7 -9.82E7 -2.77 -3.5229 -0.9939 3187548 PK04_093270 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N19 compound treatment 1.25608705E8 -3.11E7 -0.81 1.13763347E8 -5.35E7 -1.51 -1.6415 -0.9581 3068607 PK04_093271 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N20 compound treatment 1.54717921E8 -1980000.0 -0.05 1.49888037E8 -1.74E7 -0.49 -0.3829 -0.7777 3186297 PK04_093272 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N21 compound treatment 1.11433616E8 -4.53E7 -1.18 8.5954764E7 -8.13E7 -2.29 -2.458 -0.9529 3186298 PK04_093273 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CC=C)C3=O)[C@@H](O2)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N22 compound treatment 1.81299308E8 2.46E7 0.64 1.59081159E8 -8180000.0 -0.23 0.2923 0.4274 3068610 PK04_093274 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N23 compound treatment 1.10657798E8 -4.6E7 -1.21 9.3950622E7 -7.33E7 -2.07 -2.3131 -0.9671 3068635 PK04_093275 CC(=O)N1Cc2ccccc2C[C@]3(N=C(O[C@@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 N24 compound treatment 1.8978346E8 3.31E7 0.87 1.91962451E8 2.47E7 0.7 1.1046 0.9941 3186299 PK04_093276 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O01 compound treatment 1.22371587E8 -3.43E7 -0.9 1.34551769E8 -3.27E7 -0.92 -1.2872 -0.9999 3068638 PK04_093277 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O02 compound treatment 1.36795172E8 -1.99E7 -0.52 1.47671007E8 -1.96E7 -0.55 -0.7588 -0.9996 3186300 PK04_093278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O03 compound treatment 3.0664706E7 -1.26E8 -3.3 4.0990577E7 -1.26E8 -3.56 -4.849 -0.9993 3068640 PK04_093279 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O04 compound treatment 1.68922146E8 1.22E7 0.32 1.69566452E8 2300000.0 0.06 0.2722 0.8336 3186301 PK04_093280 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O05 compound treatment 1.55840513E8 -859000.0 -0.02 1.57193746E8 -1.01E7 -0.28 -0.2165 -0.7607 3068642 PK04_093281 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O06 compound treatment 1.56144963E8 -554000.0 -0.01 1.6735245E8 90300.0 0.0 -0.0085 -0.5744 3186302 PK04_093282 COCCCNC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O07 compound treatment 1.69852624E8 1.32E7 0.34 1.68109964E8 848000.0 0.02 0.2604 0.7544 3186303 PK04_093283 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O08 compound treatment 1.05456321E8 -5.12E7 -1.34 9.0376617E7 -7.69E7 -2.17 -2.4806 -0.9734 3068645 PK04_093284 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O09 compound treatment 3.4962166E7 -1.22E8 -3.19 3.267172E7 -1.35E8 -3.79 -4.9353 -0.9963 3186304 PK04_093285 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O10 compound treatment 7.5675918E7 -8.1E7 -2.12 7.340296E7 -9.39E7 -2.64 -3.37 -0.994 3186305 PK04_093286 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O11 mock treatment 1.61582884E8 4880000.0 0.13 1.6395991E8 -3300000.0 -0.09 0.0246 0.1555 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O12 mock treatment 1.64285269E8 7590000.0 0.2 1.67267349E8 5170.0 0.0 0.1405 0.7076 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O13 compound treatment 1.18565363E8 -3.81E7 -1.0 1.22138725E8 -4.51E7 -1.27 -1.605 -0.9928 3068648 PK04_093287 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O14 compound treatment 1.47957635E8 -8740000.0 -0.23 1.5698529E8 -1.03E7 -0.29 -0.3666 -0.9932 3186306 PK04_093288 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O15 compound treatment 1.45507604E8 -1.12E7 -0.29 1.52088164E8 -1.52E7 -0.43 -0.5095 -0.983 3068650 PK04_093289 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O16 compound treatment 1.13778159E8 -4.29E7 -1.12 8.6319127E7 -8.09E7 -2.28 -2.4074 -0.9468 3186307 PK04_093290 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O17 compound treatment 6.0369893E7 -9.63E7 -2.52 5.3937581E7 -1.13E8 -3.19 -4.0412 -0.9932 3186308 PK04_093291 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O18 compound treatment 1.44176498E8 -1.25E7 -0.33 1.47296712E8 -2.0E7 -0.56 -0.6296 -0.9669 3068652 PK04_093292 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O19 compound treatment 5.814409E7 -9.86E7 -2.58 5.12086E7 -1.16E8 -3.27 -4.1368 -0.9931 3186309 PK04_093293 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O20 compound treatment 1.62239724E8 5540000.0 0.15 1.53822748E8 -1.34E7 -0.38 -0.1652 -0.4075 3068654 PK04_093294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O21 compound treatment 4.705166E7 -1.1E8 -2.87 3.817408E7 -1.29E8 -3.64 -4.6018 -0.9931 3186310 PK04_093295 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O22 compound treatment 1.65970056E8 9270000.0 0.24 1.56754526E8 -1.05E7 -0.3 -0.0378 -0.0987 3186311 PK04_093296 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O23 compound treatment 1.57023823E8 325000.0 0.01 1.53337488E8 -1.39E7 -0.39 -0.2715 -0.6916 3068656 PK04_093297 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 O24 compound treatment 1.81833574E8 2.51E7 0.66 1.66833241E8 -429000.0 -0.01 0.4567 0.694 3186312 PK04_093298 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P01 compound treatment 7.6994425E7 -7.97E7 -2.09 7.4845785E7 -9.24E7 -2.6 -3.3169 -0.994 3186313 PK04_093299 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P02 compound treatment 5.4168303E7 -1.03E8 -2.68 6.1579434E7 -1.06E8 -2.98 -4.0037 -0.9987 3186314 PK04_093300 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P03 compound treatment 6.306568E7 -9.36E7 -2.45 7.2236085E7 -9.5E7 -2.68 -3.6267 -0.999 3067960 PK04_093301 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P04 compound treatment 4.784488E7 -1.09E8 -2.85 4.6408468E7 -1.21E8 -3.41 -4.4231 -0.9961 3186315 PK04_093302 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P05 compound treatment 6.0560114E7 -9.61E7 -2.52 5.8847499E7 -1.08E8 -3.06 -3.9398 -0.9954 3186316 PK04_093303 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P06 compound treatment 7.2424375E7 -8.43E7 -2.21 8.2127419E7 -8.51E7 -2.4 -3.2564 -0.9991 3067963 PK04_093304 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P07 compound treatment 1.68153897E8 1.15E7 0.3 1.64681321E8 -2580000.0 -0.07 0.1606 0.5205 3186317 PK04_093305 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P08 compound treatment 9.2036926E7 -6.47E7 -1.69 8.1588228E7 -8.57E7 -2.41 -2.9041 -0.9849 3186362 PK04_093306 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P09 compound treatment 7.3354026E7 -8.33E7 -2.18 7.1465149E7 -9.58E7 -2.7 -3.4516 -0.9944 3067965 PK04_093307 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P10 compound treatment 1.67839888E8 1.11E7 0.29 1.8175243E8 1.45E7 0.41 0.495 0.9864 3186363 PK04_093308 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P11 mock treatment 1.78146653E8 2.14E7 0.56 1.85873178E8 1.86E7 0.52 0.7678 0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P12 mock treatment 1.76059942E8 1.94E7 0.51 1.91479586E8 2.42E7 0.68 0.8409 0.9893 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P13 compound treatment 6.9843832E7 -8.69E7 -2.27 6.2840448E7 -1.04E8 -2.94 -3.6884 -0.9919 3186364 PK04_093309 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P14 compound treatment 1.75404036E8 1.87E7 0.49 1.82543392E8 1.53E7 0.43 0.6507 0.998 3067968 PK04_093310 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P15 compound treatment 1.1175226E8 -4.49E7 -1.18 8.0303324E7 -8.7E7 -2.45 -2.5648 -0.9435 3186365 PK04_093311 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P16 compound treatment 1.728764E8 1.62E7 0.42 1.79508602E8 1.22E7 0.35 0.5435 0.9948 3186366 PK04_093312 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P17 compound treatment 1.17979876E8 -3.87E7 -1.01 1.09995661E8 -5.73E7 -1.61 -1.8578 -0.9749 3067970 PK04_093313 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P18 compound treatment 1.71038189E8 1.43E7 0.38 1.64873491E8 -2390000.0 -0.07 0.2178 0.5712 3186367 PK04_093314 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P19 compound treatment 8.067313E7 -7.6E7 -1.99 6.3979319E7 -1.03E8 -2.91 -3.4653 -0.9828 3067972 PK04_093315 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CC=C)C3=O)[C@H](O2)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P20 compound treatment 1.16281432E8 -4.04E7 -1.06 1.02039903E8 -6.52E7 -1.84 -2.0478 -0.9656 3186368 PK04_093316 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P21 compound treatment 8.718844E7 -6.95E7 -1.82 7.5435701E7 -9.18E7 -2.59 -3.1164 -0.9851 3067974 PK04_093317 CC(=O)N1Cc2ccccc2C[C@@]3(N=C(O[C@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P22 compound treatment 2.05851102E8 4.92E7 1.29 1.88070818E8 2.08E7 0.59 1.3244 0.9367 3186369 PK04_093318 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P23 compound treatment 1.29722823E8 -2.7E7 -0.71 1.15600587E8 -5.17E7 -1.46 -1.5288 -0.9448 3067976 PK04_093319 CC(=O)N1Cc2ccccc2C[C@@]3(COC(=N3)c4ccc(OCCCO)cc4)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2093 P24 compound treatment 1.50064952E8 -6630000.0 -0.17 1.47468657E8 -1.98E7 -0.56 -0.5172 -0.8853 3186370 PK04_093320 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A01 compound treatment 1.74418361E8 7170000.0 0.19 1.6376841E8 9040000.0 0.25 0.3129 0.9887 3186371 PK04_094001 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A02 compound treatment 8.2934781E7 -8.43E7 -2.21 7.6018129E7 -7.87E7 -2.22 -3.129 -1.0 3067979 PK04_094002 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A03 compound treatment 1.38226424E8 -2.9E7 -0.76 1.21462358E8 -3.33E7 -0.94 -1.2001 -0.9946 3068002 PK04_094003 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A04 compound treatment 1.84356491E8 1.71E7 0.45 1.63340634E8 8610000.0 0.24 0.4883 0.9586 3186372 PK04_094004 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A05 compound treatment 2.0107361E8 3.38E7 0.89 1.77191034E8 2.25E7 0.63 1.0737 0.9865 3068007 PK04_094005 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A06 compound treatment 1.49954704E8 -1.73E7 -0.45 1.28468652E8 -2.63E7 -0.74 -0.8434 -0.9722 3186373 PK04_094006 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A07 compound treatment 1.62589956E8 -4660000.0 -0.12 1.27007384E8 -2.77E7 -0.78 -0.6386 -0.8077 3186374 PK04_094007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A08 compound treatment 1.32855066E8 -3.44E7 -0.9 1.12522395E8 -4.22E7 -1.19 -1.4776 -0.9906 3068010 PK04_094008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A09 compound treatment 1.95823741E8 2.86E7 0.75 1.67523476E8 1.28E7 0.36 0.7839 0.944 3186375 PK04_094009 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A10 compound treatment 1.27421192E8 -3.98E7 -1.04 8.3904267E7 -7.08E7 -2.0 -2.1485 -0.9541 3068013 PK04_094010 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A11 compound treatment 1.37061096E8 -3.02E7 -0.79 9.7180123E7 -5.75E7 -1.62 -1.7055 -0.9454 3186376 PK04_094011 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A12 compound treatment 1.06880565E8 -6.04E7 -1.58 8.6864781E7 -6.79E7 -1.91 -2.4697 -0.9955 3186377 PK04_094012 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A13 mock treatment 2.04825226E8 3.76E7 0.98 1.93789306E8 3.91E7 1.1 1.4739 0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A14 mock treatment 1.85087481E8 1.78E7 0.47 1.64515463E8 9790000.0 0.28 0.5252 0.9685 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A15 compound treatment 1.20219992E8 -4.7E7 -1.23 9.6716863E7 -5.8E7 -1.63 -2.0265 -0.9902 3068016 PK04_094013 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A16 compound treatment 1.27688184E8 -3.96E7 -1.04 1.64543071E8 9820000.0 0.28 -0.5367 -0.5007 3186378 PK04_094014 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A17 compound treatment 1.68991396E8 1740000.0 0.05 1.51155857E8 -3570000.0 -0.1 -0.0389 -0.3523 3068018 PK04_094015 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A18 compound treatment 1.37528886E8 -2.97E7 -0.78 1.23589531E8 -3.11E7 -0.88 -1.1706 -0.9982 3186379 PK04_094016 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A19 compound treatment 4.7916745E7 -1.19E8 -3.12 4.4360698E7 -1.1E8 -3.11 -4.408 -1.0 3186380 PK04_094017 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A20 compound treatment 1.70000445E8 2750000.0 0.07 1.39733815E8 -1.5E7 -0.42 -0.2478 -0.5783 3068020 PK04_094018 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A21 compound treatment 2.03019615E8 3.58E7 0.94 1.84877158E8 3.02E7 0.85 1.2629 0.9988 3186381 PK04_094019 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A22 compound treatment 2.14633245E8 4.74E7 1.24 1.94163368E8 3.94E7 1.11 1.6629 0.9985 3186437 PK04_094020 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A23 compound treatment 2.02868601E8 3.56E7 0.93 1.85207438E8 3.05E7 0.86 1.2667 0.9992 3068021 PK04_094021 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 A24 compound treatment 2.32382709E8 6.51E7 1.7 2.0760341E8 5.29E7 1.49 2.2592 0.9977 3186438 PK04_094022 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B01 compound treatment 1.56169619E8 -1.11E7 -0.29 1.34339574E8 -2.04E7 -0.57 -0.6113 -0.9499 3186439 PK04_094023 CCCN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B02 compound treatment 1.30591422E8 -3.67E7 -0.96 1.28675147E8 -2.61E7 -0.73 -1.1977 -0.9913 3089331 PK04_094024 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B03 compound treatment 1.69362133E8 2110000.0 0.06 1.43166591E8 -1.16E7 -0.33 -0.1913 -0.5788 3068022 PK04_094025 CCCN1C(=O)[C@]2(Cc3ccccc13)N=C(O[C@@H]2c4ccccc4)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B04 compound treatment 1.13316392E8 -5.39E7 -1.41 7.3952697E7 -8.08E7 -2.28 -2.6078 -0.9736 3089332 PK04_094026 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B05 compound treatment 1.5672531E8 -1.05E7 -0.28 1.13768614E8 -4.1E7 -1.15 -1.011 -0.852 3186440 PK04_094027 CCCN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B06 compound treatment 8.2660907E7 -8.46E7 -2.21 8.7137507E7 -6.76E7 -1.9 -2.9125 -0.9972 3000708 PK04_094028 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B07 compound treatment 7.9111169E7 -8.81E7 -2.31 6.3974954E7 -9.08E7 -2.56 -3.4398 -0.9987 3068023 PK04_094029 CN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B08 compound treatment 1.22059073E8 -4.52E7 -1.18 1.05695987E8 -4.9E7 -1.38 -1.8135 -0.997 3089333 PK04_094030 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B09 compound treatment 1.171895E8 -5.01E7 -1.31 8.5064822E7 -6.97E7 -1.96 -2.3147 -0.9807 3186441 PK04_094031 CN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B10 compound treatment 9.492853E7 -7.23E7 -1.89 7.5151068E7 -7.96E7 -2.24 -2.9243 -0.9965 3089654 PK04_094032 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B11 compound treatment 7.7320588E7 -8.99E7 -2.35 6.1880468E7 -9.28E7 -2.62 -3.5147 -0.9986 3186442 PK04_094033 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B12 compound treatment 4.4566405E7 -1.23E8 -3.21 4.9238088E7 -1.05E8 -2.97 -4.3729 -0.9993 3089334 PK04_094034 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B13 mock treatment 1.61072652E8 -6180000.0 -0.16 1.35124246E8 -1.96E7 -0.55 -0.505 -0.8773 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B14 mock treatment 1.68454985E8 1210000.0 0.03 1.50216708E8 -4510000.0 -0.13 -0.0676 -0.516 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B15 compound treatment 1.29960622E8 -3.73E7 -0.98 1.07885504E8 -4.68E7 -1.32 -1.6236 -0.989 3068024 PK04_094035 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B16 compound treatment 1.30113336E8 -3.71E7 -0.97 8.7254514E7 -6.75E7 -1.9 -2.0319 -0.9515 3000709 PK04_094036 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B17 compound treatment 1.36891712E8 -3.04E7 -0.79 1.12292817E8 -4.24E7 -1.2 -1.4075 -0.9803 3186443 PK04_094037 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B18 compound treatment 1.35451333E8 -3.18E7 -0.83 1.18655505E8 -3.61E7 -1.02 -1.3074 -0.9951 3089363 PK04_094038 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B19 compound treatment 9.038375E7 -7.69E7 -2.01 7.9528994E7 -7.52E7 -2.12 -2.9212 -0.9997 3068025 PK04_094039 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B20 compound treatment 7.5772932E7 -9.15E7 -2.39 6.6072209E7 -8.87E7 -2.5 -3.4598 -0.9998 3089652 PK04_094040 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B21 compound treatment 1.27862241E8 -3.94E7 -1.03 1.20290247E8 -3.44E7 -0.97 -1.4153 -0.9995 3186444 PK04_094041 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B22 compound treatment 6.9407855E7 -9.78E7 -2.56 7.3936947E7 -8.08E7 -2.28 -3.4209 -0.9983 3089653 PK04_094042 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B23 compound treatment 7.7600607E7 -8.96E7 -2.35 7.826123E7 -7.65E7 -2.15 -3.1831 -0.9991 3186445 PK04_094043 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 B24 compound treatment 1.55651656E8 -1.16E7 -0.3 1.45947936E8 -8780000.0 -0.25 -0.3896 -0.9948 3089657 PK04_094044 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C01 compound treatment 1.99864051E8 3.26E7 0.85 1.81277269E8 2.66E7 0.75 1.1327 0.9978 3068026 PK04_094045 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C02 compound treatment 1.24211506E8 -4.3E7 -1.13 1.05169467E8 -4.96E7 -1.4 -1.7841 -0.9943 3068051 PK04_094046 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C03 compound treatment 1.77435226E8 1.02E7 0.27 1.63857209E8 9130000.0 0.26 0.3705 0.9998 3068052 PK04_094047 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C04 compound treatment 1.75658534E8 8410000.0 0.22 1.63977318E8 9250000.0 0.26 0.34 0.9965 3068053 PK04_094048 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCOCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C05 compound treatment 1.49215991E8 -1.8E7 -0.47 1.17137276E8 -3.76E7 -1.06 -1.0828 -0.9337 3068054 PK04_094049 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C06 compound treatment 1.5305685E8 -1.42E7 -0.37 1.29704997E8 -2.5E7 -0.71 -0.7613 -0.9552 3186446 PK04_094050 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C07 compound treatment 1.69377549E8 2130000.0 0.06 1.64525376E8 9800000.0 0.28 0.2346 0.833 3068055 PK04_094051 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C08 compound treatment 1.56428832E8 -1.08E7 -0.28 1.42731347E8 -1.2E7 -0.34 -0.4393 -0.9961 3186447 PK04_094052 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C09 compound treatment 1.58149219E8 -9100000.0 -0.24 1.41038245E8 -1.37E7 -0.39 -0.4412 -0.9732 3068056 PK04_094053 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C10 compound treatment 9.7271473E7 -7.0E7 -1.83 6.659462E7 -8.81E7 -2.48 -3.0515 -0.9888 3186448 PK04_094054 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C11 mock treatment 1.74379014E8 7130000.0 0.19 1.70123384E8 1.54E7 0.43 0.4388 0.929 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C12 mock treatment 1.63261472E8 -3990000.0 -0.1 1.62149559E8 7420000.0 0.21 0.0741 0.3169 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C13 compound treatment 1.53571249E8 -1.37E7 -0.36 1.58279746E8 3550000.0 0.1 -0.1824 -0.4906 3186449 PK04_094055 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C14 compound treatment 1.33294677E8 -3.4E7 -0.89 1.13659293E8 -4.11E7 -1.16 -1.4468 -0.9915 3068057 PK04_094056 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C15 mock treatment 1.58821583E8 -8430000.0 -0.22 1.51283525E8 -3440000.0 -0.1 -0.2246 -0.9319 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C16 mock treatment 1.5697446E8 -1.03E7 -0.27 1.49423543E8 -5300000.0 -0.15 -0.2959 -0.9615 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C17 compound treatment 1.71802052E8 4550000.0 0.12 1.58512024E8 3790000.0 0.11 0.1597 0.9985 3186450 PK04_094057 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C18 compound treatment 1.35052691E8 -3.22E7 -0.84 1.19894309E8 -3.48E7 -0.98 -1.2901 -0.9971 3186451 PK04_094058 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C19 compound treatment 1.48912086E8 -1.83E7 -0.48 1.48611903E8 -6110000.0 -0.17 -0.4613 -0.9044 3068058 PK04_094059 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C20 compound treatment 8.1648581E7 -8.56E7 -2.24 9.9165221E7 -5.56E7 -1.57 -2.6916 -0.9846 3186452 PK04_094060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C21 compound treatment 1.6332126E8 -3930000.0 -0.1 1.57952516E8 3230000.0 0.09 -0.0084 -0.0615 3068059 PK04_094061 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C22 compound treatment 1.58665188E8 -8580000.0 -0.22 1.60185169E8 5460000.0 0.15 -0.0501 -0.1841 3186453 PK04_094062 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C23 compound treatment 1.73522226E8 6270000.0 0.16 1.67774701E8 1.3E7 0.37 0.3761 0.934 3186454 PK04_094063 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 C24 compound treatment 1.99236347E8 3.2E7 0.84 1.91828416E8 3.71E7 1.05 1.3314 0.9939 3068060 PK04_094064 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D01 compound treatment 7.9941672E7 -8.73E7 -2.29 8.3858015E7 -7.09E7 -2.0 -3.0282 -0.9977 3186455 PK04_094065 CN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D02 compound treatment 1.31307613E8 -3.59E7 -0.94 1.14842467E8 -3.99E7 -1.12 -1.46 -0.9961 3000713 PK04_094066 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D03 compound treatment 8.8485975E7 -7.88E7 -2.06 1.1588978E8 -3.88E7 -1.09 -2.2318 -0.9561 3186456 PK04_094067 CCCN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D04 compound treatment 1.23218293E8 -4.4E7 -1.15 1.02214811E8 -5.25E7 -1.48 -1.8614 -0.9924 3089658 PK04_094068 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D05 compound treatment 8.1055552E7 -8.62E7 -2.26 7.7718141E7 -7.7E7 -2.17 -3.13 -0.9998 3068061 PK04_094069 CCCN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D06 compound treatment 1.2962617E8 -3.76E7 -0.98 1.22910299E8 -3.18E7 -0.9 -1.3304 -0.9989 3089659 PK04_094070 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D07 compound treatment 9.5041003E7 -7.22E7 -1.89 7.6026592E7 -7.87E7 -2.22 -2.9048 -0.9968 3186457 PK04_094071 CCCN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D08 compound treatment 1.45365512E8 -2.19E7 -0.57 1.37065346E8 -1.77E7 -0.5 -0.757 -0.9975 3089664 PK04_094072 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D09 compound treatment 1.3971927E8 -2.75E7 -0.72 9.7612975E7 -5.71E7 -1.61 -1.6477 -0.9343 3068062 PK04_094073 CCCN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D10 compound treatment 8.0673422E7 -8.66E7 -2.27 7.0349559E7 -8.44E7 -2.38 -3.2839 -0.9997 3000714 PK04_094074 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D11 mock treatment 1.57355449E8 -9890000.0 -0.26 1.45137757E8 -9590000.0 -0.27 -0.3742 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D12 mock treatment 1.70724717E8 3470000.0 0.09 1.64343884E8 9620000.0 0.27 0.256 0.8953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D13 compound treatment 9.5186087E7 -7.21E7 -1.89 8.9919679E7 -6.48E7 -1.83 -2.6253 -0.9999 3186504 PK04_094075 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D14 compound treatment 1.20453927E8 -4.68E7 -1.22 1.10671298E8 -4.41E7 -1.24 -1.7441 -1.0 3089660 PK04_094076 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D15 mock treatment 1.46618176E8 -2.06E7 -0.54 1.42821526E8 -1.19E7 -0.34 -0.6191 -0.9738 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D16 mock treatment 1.7414198E8 6890000.0 0.18 1.60068417E8 5340000.0 0.15 0.234 0.9959 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D17 compound treatment 1.3960534E8 -2.76E7 -0.72 1.08193232E8 -4.65E7 -1.31 -1.4389 -0.9607 3186505 PK04_094077 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D18 compound treatment 1.19478071E8 -4.78E7 -1.25 1.17127821E8 -3.76E7 -1.06 -1.6335 -0.9966 3000715 PK04_094078 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D19 compound treatment 1.55465093E8 -1.18E7 -0.31 1.54606006E8 -121000.0 0.0 -0.2205 -0.7149 3068063 PK04_094079 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(Cc5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D20 compound treatment 1.20639255E8 -4.66E7 -1.22 1.1422424E8 -4.05E7 -1.14 -1.6698 -0.9994 3089662 PK04_094080 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D21 compound treatment 7.4832359E7 -9.24E7 -2.42 1.09714432E8 -4.5E7 -1.27 -2.6076 -0.9546 3186506 PK04_094081 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D22 compound treatment 1.41853286E8 -2.54E7 -0.66 1.44918442E8 -9810000.0 -0.28 -0.6655 -0.9244 3000716 PK04_094082 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D23 compound treatment 8.0755769E7 -8.65E7 -2.26 9.3224585E7 -6.15E7 -1.73 -2.8265 -0.9913 3068064 PK04_094083 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 D24 compound treatment 7.8799939E7 -8.85E7 -2.32 5.4875022E7 -9.99E7 -2.81 -3.6269 -0.9953 3000811 PK04_094084 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E01 mock treatment 2.15741116E8 4.85E7 1.27 2.03085529E8 4.84E7 1.36 1.8612 0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E02 mock treatment 2.06672683E8 3.94E7 1.03 1.92488851E8 3.78E7 1.06 1.4822 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E03 compound treatment 1.79450441E8 1.22E7 0.32 1.63094466E8 8370000.0 0.24 0.3926 0.9889 3186507 PK04_094085 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E04 compound treatment 1.25446048E8 -4.18E7 -1.09 1.13192679E8 -4.15E7 -1.17 -1.6014 -0.9994 3186508 PK04_094086 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E05 compound treatment 1.67015961E8 -234000.0 -0.01 1.61513805E8 6790000.0 0.19 0.1309 0.6841 3068065 PK04_094087 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E06 compound treatment 1.40969804E8 -2.63E7 -0.69 1.24074345E8 -3.07E7 -0.86 -1.0972 -0.9936 3186509 PK04_094088 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E07 compound treatment 7.7467931E7 -8.98E7 -2.35 7.9256204E7 -7.55E7 -2.13 -3.1657 -0.9988 3068066 PK04_094089 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E08 compound treatment 1.55431434E8 -1.18E7 -0.31 1.37951019E8 -1.68E7 -0.47 -0.553 -0.9789 3186510 PK04_094090 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E09 mock treatment 1.68652791E8 1400000.0 0.04 1.54621284E8 -105000.0 0.0 0.0239 0.6478 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E10 mock treatment 1.64914821E8 -2340000.0 -0.06 1.5680236E8 2080000.0 0.06 -0.0019 -0.022 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E11 compound treatment 8.0235762E7 -8.7E7 -2.28 7.0055119E7 -8.47E7 -2.39 -3.2978 -0.9997 3186511 PK04_094091 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E12 compound treatment 1.62685281E8 -4560000.0 -0.12 1.58091144E8 3360000.0 0.09 -0.0175 -0.1144 3068067 PK04_094092 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E13 compound treatment 1.38057701E8 -2.92E7 -0.76 1.30214525E8 -2.45E7 -0.69 -1.0288 -0.9987 3186512 PK04_094093 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E14 compound treatment 1.32207263E8 -3.5E7 -0.92 1.27754565E8 -2.7E7 -0.76 -1.1861 -0.9956 3068068 PK04_094094 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E15 compound treatment 1.522598E8 -1.5E7 -0.39 1.44978911E8 -9750000.0 -0.27 -0.4717 -0.9848 3186513 PK04_094095 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E16 compound treatment 1.4696482E8 -2.03E7 -0.53 1.33533703E8 -2.12E7 -0.6 -0.7978 -0.9983 3068069 PK04_094096 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E17 mock treatment 1.67119564E8 -130000.0 0.0 1.5042868E8 -4300000.0 -0.12 -0.0881 -0.7267 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E18 mock treatment 1.63484864E8 -3770000.0 -0.1 1.57487832E8 2760000.0 0.08 -0.0147 -0.1168 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E19 compound treatment 1.6904948E8 1800000.0 0.05 1.57183397E8 2460000.0 0.07 0.0823 0.9824 3186514 PK04_094097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E20 compound treatment 9.2941084E7 -7.43E7 -1.95 1.14656E8 -4.01E7 -1.13 -2.1739 -0.9665 3186515 PK04_094098 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E21 compound treatment 1.02516861E8 -6.47E7 -1.69 1.24982306E8 -2.97E7 -0.84 -1.7909 -0.9473 3068070 PK04_094099 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E22 compound treatment 1.39802998E8 -2.74E7 -0.72 1.31029271E8 -2.37E7 -0.67 -0.9802 -0.9993 3186516 PK04_094100 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E23 compound treatment 1.65099929E8 -2150000.0 -0.06 1.57883248E8 3160000.0 0.09 0.0231 0.2195 3068071 PK04_094101 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 E24 compound treatment 7.4423942E7 -9.28E7 -2.43 7.1667152E7 -8.31E7 -2.34 -3.3733 -0.9998 3186517 PK04_094102 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F01 mock treatment 2.29437496E8 6.22E7 1.63 2.02367383E8 4.76E7 1.34 2.1004 0.9954 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F02 mock treatment 2.05464209E8 3.82E7 1.0 1.94247941E8 3.95E7 1.11 1.4949 0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F03 compound treatment 8.4892168E7 -8.24E7 -2.16 8.4906549E7 -6.98E7 -1.97 -2.9157 -0.999 3068072 PK04_094103 CN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F04 compound treatment 8.1368478E7 -8.59E7 -2.25 7.4015333E7 -8.07E7 -2.27 -3.1979 -1.0 3000813 PK04_094104 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F05 compound treatment 1.17459436E8 -4.98E7 -1.3 1.11163636E8 -4.36E7 -1.23 -1.7897 -0.9996 3186518 PK04_094105 CN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F06 compound treatment 6.814729E7 -9.91E7 -2.59 5.4229554E7 -1.0E8 -2.83 -3.8369 -0.999 3000814 PK04_094106 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F07 compound treatment 6.1921823E7 -1.05E8 -2.76 5.6868281E7 -9.79E7 -2.76 -3.8996 -1.0 3186519 PK04_094107 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F08 compound treatment 9.137745E7 -7.59E7 -1.99 7.9199159E7 -7.55E7 -2.13 -2.9094 -0.9994 3089667 PK04_094108 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F09 mock treatment 1.6642783E8 -822000.0 -0.02 1.51682753E8 -3040000.0 -0.09 -0.0759 -0.8579 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F10 mock treatment 1.58304394E8 -8950000.0 -0.23 1.55610478E8 884000.0 0.02 -0.148 -0.6284 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F11 compound treatment 8.9211108E7 -7.8E7 -2.04 8.5115182E7 -6.96E7 -1.96 -2.8316 -0.9998 3068073 PK04_094109 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F12 compound treatment 9.0186E7 -7.71E7 -2.02 8.5049316E7 -6.97E7 -1.96 -2.8149 -0.9999 3089654 PK04_094110 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F13 compound treatment 7.43746E7 -9.29E7 -2.43 1.0108511E8 -5.36E7 -1.51 -2.788 -0.9739 3186520 PK04_094111 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F14 compound treatment 5.6907652E7 -1.1E8 -2.89 6.439558E7 -9.03E7 -2.55 -3.8424 -0.998 3089708 PK04_094112 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F15 compound treatment 5.3295061E7 -1.14E8 -2.98 5.6151031E7 -9.86E7 -2.78 -4.0736 -0.9994 3186521 PK04_094113 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F16 compound treatment 8.0603456E7 -8.66E7 -2.27 7.9682696E7 -7.5E7 -2.11 -3.0992 -0.9994 3000817 PK04_094114 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F17 mock treatment 1.58697928E8 -8550000.0 -0.22 1.50785374E8 -3940000.0 -0.11 -0.2368 -0.9477 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F18 mock treatment 1.70887334E8 3640000.0 0.1 1.56217863E8 1490000.0 0.04 0.097 0.9324 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F19 compound treatment 7.2487694E7 -9.48E7 -2.48 1.05322421E8 -4.94E7 -1.39 -2.7385 -0.9627 3068074 PK04_094115 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F20 compound treatment 9.6262268E7 -7.1E7 -1.86 8.8587513E7 -6.61E7 -1.86 -2.6319 -1.0 3089709 PK04_094116 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F21 compound treatment 8.4913348E7 -8.23E7 -2.16 9.5327241E7 -5.94E7 -1.67 -2.7077 -0.9922 3186522 PK04_094117 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(Cc5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F22 compound treatment 9.1716641E7 -7.55E7 -1.98 9.0984665E7 -6.37E7 -1.8 -2.6683 -0.9989 3000821 PK04_094118 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F23 compound treatment 1.01870701E8 -6.54E7 -1.71 1.3424663E8 -2.05E7 -0.58 -1.6183 -0.896 3186523 PK04_094119 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 F24 compound treatment 1.14200327E8 -5.3E7 -1.39 1.24012853E8 -3.07E7 -0.87 -1.594 -0.9741 3089711 PK04_094120 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G01 compound treatment 2.0912336E8 4.19E7 1.1 1.76488303E8 2.18E7 0.61 1.2087 0.9623 3068075 PK04_094121 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G02 compound treatment 2.02758443E8 3.55E7 0.93 1.89700364E8 3.5E7 0.99 1.3542 0.9996 3186524 PK04_094122 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G03 mock treatment 1.97950006E8 3.07E7 0.8 1.86809295E8 3.21E7 0.9 1.2075 0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G04 mock treatment 1.92436385E8 2.52E7 0.66 1.7538408E8 2.07E7 0.58 0.8778 0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G05 compound treatment 1.63071562E8 -4180000.0 -0.11 1.58793282E8 4070000.0 0.11 0.0037 0.0233 3186575 PK04_094123 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G06 compound treatment 1.4428905E8 -2.3E7 -0.6 1.30190673E8 -2.45E7 -0.69 -0.9139 -0.9976 3186576 PK04_094124 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G07 compound treatment 1.47825671E8 -1.94E7 -0.51 1.43597616E8 -1.11E7 -0.31 -0.5813 -0.973 3068110 PK04_094125 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G08 compound treatment 1.39435327E8 -2.78E7 -0.73 1.25078375E8 -2.96E7 -0.84 -1.1056 -0.9976 3186577 PK04_094126 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G09 compound treatment 6.5996906E7 -1.01E8 -2.65 6.1527886E7 -9.32E7 -2.63 -3.7313 -1.0 3068111 PK04_094127 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G10 compound treatment 1.59781095E8 -7470000.0 -0.2 1.46892967E8 -7830000.0 -0.22 -0.2943 -0.9982 3186578 PK04_094128 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G11 compound treatment 1.41437209E8 -2.58E7 -0.68 1.34456474E8 -2.03E7 -0.57 -0.8817 -0.9965 3186579 PK04_094129 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G12 compound treatment 1.43409777E8 -2.38E7 -0.62 1.38755417E8 -1.6E7 -0.45 -0.7595 -0.9871 3068112 PK04_094130 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G13 compound treatment 1.59762788E8 -7490000.0 -0.2 1.5432567E8 -401000.0 -0.01 -0.1466 -0.7466 3186580 PK04_094131 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCCN3CCOCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G14 compound treatment 1.33641016E8 -3.36E7 -0.88 1.26689661E8 -2.8E7 -0.79 -1.1808 -0.9986 3186581 PK04_094132 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G15 compound treatment 1.43256241E8 -2.4E7 -0.63 1.37398806E8 -1.73E7 -0.49 -0.7894 -0.9923 3068113 PK04_094133 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G16 compound treatment 1.15843621E8 -5.14E7 -1.35 1.16319226E8 -3.84E7 -1.08 -1.7169 -0.9942 3186582 PK04_094134 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G17 compound treatment 1.5801382E8 -9240000.0 -0.24 1.55759807E8 1030000.0 0.03 -0.1504 -0.6175 3186583 PK04_094135 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G18 compound treatment 1.08071887E8 -5.92E7 -1.55 1.04277199E8 -5.04E7 -1.42 -2.1007 -0.9991 3068114 PK04_094136 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G19 mock treatment 1.73066768E8 5820000.0 0.15 1.55999691E8 1270000.0 0.04 0.133 0.8504 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G20 mock treatment 1.78245034E8 1.1E7 0.29 1.61493539E8 6770000.0 0.19 0.3384 0.98 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G21 compound treatment 1.83363278E8 1.61E7 0.42 1.68975621E8 1.42E7 0.4 0.5822 0.9997 3186584 PK04_094137 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G22 compound treatment 1.7791112E8 1.07E7 0.28 1.64167972E8 9440000.0 0.27 0.3855 0.9997 3068115 PK04_094138 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G23 compound treatment 1.69218145E8 1970000.0 0.05 1.66057515E8 1.13E7 0.32 0.2622 0.8107 3186585 PK04_094139 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 G24 compound treatment 2.11698897E8 4.44E7 1.16 1.97145868E8 4.24E7 1.2 1.668 0.9999 3186586 PK04_094140 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCc3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H01 compound treatment 6.0809891E7 -1.06E8 -2.79 7.9664555E7 -7.51E7 -2.12 -3.4659 -0.9908 3068116 PK04_094141 CCCN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H02 compound treatment 1.02165868E8 -6.51E7 -1.7 9.4042954E7 -6.07E7 -1.71 -2.4139 -1.0 3000914 PK04_094142 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H03 mock treatment 1.88911634E8 2.17E7 0.57 1.79149183E8 2.44E7 0.69 0.8876 0.9954 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H04 mock treatment 1.75093042E8 7840000.0 0.21 1.70370873E8 1.56E7 0.44 0.4569 0.9395 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H05 compound treatment 1.24364834E8 -4.29E7 -1.12 8.9216454E7 -6.55E7 -1.85 -2.0992 -0.9716 3068117 PK04_094143 CCCN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H06 compound treatment 5.8677882E7 -1.09E8 -2.84 5.0432445E7 -1.04E8 -2.94 -4.0879 -0.9999 3089723 PK04_094144 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H07 compound treatment 7.2508813E7 -9.47E7 -2.48 7.0563666E7 -8.42E7 -2.37 -3.4307 -0.9998 3186589 PK04_094145 CN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H08 compound treatment 9.0972502E7 -7.63E7 -2.0 7.7533268E7 -7.72E7 -2.18 -2.9501 -0.9991 3089724 PK04_094146 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H09 compound treatment 1.33342115E8 -3.39E7 -0.89 1.17681433E8 -3.7E7 -1.04 -1.3658 -0.9967 3186590 PK04_094147 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(C(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H10 compound treatment 1.13196505E8 -5.41E7 -1.41 9.7360047E7 -5.74E7 -1.62 -2.1436 -0.9978 3000917 PK04_094148 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H11 compound treatment 9.525234E7 -7.2E7 -1.88 7.6301126E7 -7.84E7 -2.21 -2.8954 -0.9969 3068119 PK04_094149 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H12 compound treatment 7.5549617E7 -9.17E7 -2.4 7.4248635E7 -8.05E7 -2.27 -3.301 -0.9996 3089768 PK04_094150 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H13 compound treatment 1.11287734E8 -5.6E7 -1.46 1.02482008E8 -5.22E7 -1.47 -2.0769 -1.0 3186593 PK04_094151 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H14 compound treatment 1.43674398E8 -2.36E7 -0.62 1.35898481E8 -1.88E7 -0.53 -0.8116 -0.9972 3089763 PK04_094152 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H15 compound treatment 9.1843716E7 -7.54E7 -1.97 9.3565341E7 -6.12E7 -1.72 -2.6145 -0.9977 3186594 PK04_094153 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H16 compound treatment 9.470254E7 -7.25E7 -1.9 9.271575E7 -6.2E7 -1.75 -2.5785 -0.9991 3089764 PK04_094154 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H17 compound treatment 1.09520968E8 -5.77E7 -1.51 1.39249412E8 -1.55E7 -0.44 -1.377 -0.8755 3068121 PK04_094155 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(C(=O)c5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H18 compound treatment 1.12592687E8 -5.47E7 -1.43 1.0822429E8 -4.65E7 -1.31 -1.9383 -0.999 3000919 PK04_094156 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H19 mock treatment 1.72098931E8 4850000.0 0.13 1.56271429E8 1540000.0 0.04 0.1205 0.8982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H20 mock treatment 1.69074236E8 1820000.0 0.05 1.61362191E8 6640000.0 0.19 0.166 0.8601 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H21 compound treatment 1.28858413E8 -3.84E7 -1.0 1.41874965E8 -1.29E7 -0.36 -0.9667 -0.905 3068122 PK04_094157 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H22 compound treatment 7.2543083E7 -9.47E7 -2.48 7.0781857E7 -8.39E7 -2.37 -3.4257 -0.9997 3089766 PK04_094158 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H23 compound treatment 1.06965774E8 -6.03E7 -1.58 1.16796519E8 -3.79E7 -1.07 -1.8717 -0.982 3068123 PK04_094159 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 H24 compound treatment 1.53504659E8 -1.37E7 -0.36 1.47764597E8 -6960000.0 -0.2 -0.3932 -0.9593 3089769 PK04_094160 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I01 compound treatment 1.40913873E8 -2.63E7 -0.69 1.38426967E8 -1.63E7 -0.46 -0.8123 -0.9805 3186651 PK04_094161 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I02 compound treatment 1.61389842E8 -5860000.0 -0.15 1.75608811E8 2.09E7 0.59 0.3076 0.5059 3068124 PK04_094162 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I03 compound treatment 1.58869643E8 -8380000.0 -0.22 1.42597165E8 -1.21E7 -0.34 -0.3968 -0.977 3186652 PK04_094163 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I04 compound treatment 1.2804516E8 -3.92E7 -1.03 1.06904572E8 -4.78E7 -1.35 -1.6786 -0.991 3068125 PK04_094164 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I05 mock treatment 1.69882403E8 2630000.0 0.07 1.61647281E8 6920000.0 0.2 0.1866 0.9023 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I06 mock treatment 1.73811745E8 6560000.0 0.17 1.62300663E8 7570000.0 0.21 0.2724 0.9942 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I07 compound treatment 1.38032782E8 -2.92E7 -0.76 1.25649335E8 -2.91E7 -0.82 -1.1202 -0.9994 3186653 PK04_094165 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I08 compound treatment 1.67577582E8 328000.0 0.01 1.50319466E8 -4410000.0 -0.12 -0.0818 -0.6567 3068126 PK04_094166 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I09 compound treatment 1.6526263E8 -1990000.0 -0.05 1.47614787E8 -7110000.0 -0.2 -0.1785 -0.8621 3186654 PK04_094167 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I10 compound treatment 1.2238934E8 -4.49E7 -1.17 1.12748132E8 -4.2E7 -1.18 -1.6668 -1.0 3068572 PK04_094168 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I11 compound treatment 1.13569669E8 -5.37E7 -1.41 1.12054897E8 -4.27E7 -1.2 -1.8439 -0.997 3186655 PK04_094169 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I12 compound treatment 7.26061E7 -9.46E7 -2.48 7.4852332E7 -7.99E7 -2.25 -3.3435 -0.9989 3186656 PK04_094170 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I13 compound treatment 1.23686567E8 -4.36E7 -1.14 1.21599217E8 -3.31E7 -0.93 -1.4665 -0.9951 3068573 PK04_094171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I14 compound treatment 1.29828488E8 -3.74E7 -0.98 1.26159829E8 -2.86E7 -0.81 -1.2619 -0.9953 3186657 PK04_094172 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I15 compound treatment 9.189106E7 -7.54E7 -1.97 9.7425688E7 -5.73E7 -1.61 -2.5367 -0.9951 3068574 PK04_094173 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I16 compound treatment 6.8952058E7 -9.83E7 -2.57 6.9459759E7 -8.53E7 -2.4 -3.5186 -0.9994 3186658 PK04_094174 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I17 compound treatment 6.0219344E7 -1.07E8 -2.8 6.5835814E7 -8.89E7 -2.5 -3.7524 -0.9984 3186659 PK04_094175 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I18 compound treatment 7.0136262E7 -9.71E7 -2.54 7.6281333E7 -7.84E7 -2.21 -3.3607 -0.9976 3068575 PK04_094176 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I19 compound treatment 1.60468111E8 -6780000.0 -0.18 1.47670518E8 -7060000.0 -0.2 -0.2661 -0.9984 3186660 PK04_094177 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I20 compound treatment 7.7972614E7 -8.93E7 -2.34 9.8333388E7 -5.64E7 -1.59 -2.7762 -0.9823 3068577 PK04_094178 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I21 mock treatment 1.76413806E8 9160000.0 0.24 1.64417235E8 9690000.0 0.27 0.3627 0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I22 mock treatment 1.81335421E8 1.41E7 0.37 1.64460972E8 9730000.0 0.27 0.4547 0.9894 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I23 compound treatment 1.89575158E8 2.23E7 0.58 1.72261431E8 1.75E7 0.49 0.7626 0.9965 3186661 PK04_094179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 I24 compound treatment 8.2526895E7 -8.47E7 -2.22 8.1308912E7 -7.34E7 -2.07 -3.0312 -0.9994 3186662 PK04_094180 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J01 compound treatment 1.34906721E8 -3.23E7 -0.85 1.31762997E8 -2.3E7 -0.65 -1.0563 -0.9912 3068611 PK04_094181 CN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J02 compound treatment 7.7673773E7 -8.96E7 -2.34 7.0652837E7 -8.41E7 -2.37 -3.3333 -1.0 3089770 PK04_094182 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J03 compound treatment 1.32004919E8 -3.52E7 -0.92 1.26116116E8 -2.86E7 -0.81 -1.2225 -0.9977 3068612 PK04_094183 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J04 compound treatment 1.1903364E8 -4.82E7 -1.26 9.6229895E7 -5.85E7 -1.65 -2.0581 -0.9913 3001007 PK04_094184 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J05 mock treatment 1.67345393E8 95400.0 0.0 1.66783783E8 1.21E7 0.34 0.242 0.7123 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J06 mock treatment 1.65040338E8 -2210000.0 -0.06 1.52809822E8 -1920000.0 -0.05 -0.0791 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J07 compound treatment 1.01306116E8 -6.59E7 -1.73 8.6207761E7 -6.85E7 -1.93 -2.586 -0.9984 3186665 PK04_094185 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J08 compound treatment 1.36538222E8 -3.07E7 -0.8 1.2778482E8 -2.69E7 -0.76 -1.1053 -0.9996 3089771 PK04_094186 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J09 compound treatment 8.7246791E7 -8.0E7 -2.09 8.6551281E7 -6.82E7 -1.92 -2.8393 -0.9991 3186666 PK04_094187 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J10 compound treatment 1.17818016E8 -4.94E7 -1.29 1.08497809E8 -4.62E7 -1.3 -1.8362 -1.0 3089776 PK04_094188 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J11 compound treatment 1.53406198E8 -1.38E7 -0.36 1.44417943E8 -1.03E7 -0.29 -0.4617 -0.994 3068615 PK04_094189 CCCN1C(=O)[C@]2(COC(=N2)c3ccc(OCCCO)cc3)Cc4ccccc14 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J12 compound treatment 8.6634482E7 -8.06E7 -2.11 8.4553261E7 -7.02E7 -1.98 -2.8905 -0.9995 3001011 PK04_094190 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J13 compound treatment 6.4901782E7 -1.02E8 -2.68 7.2668493E7 -8.21E7 -2.31 -3.5296 -0.9973 3068616 PK04_094191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J14 compound treatment 1.17467473E8 -4.98E7 -1.3 1.15793469E8 -3.89E7 -1.1 -1.6973 -0.9963 3089772 PK04_094192 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J15 compound treatment 5.9157614E7 -1.08E8 -2.83 6.1343722E7 -9.34E7 -2.63 -3.8616 -0.9993 3068617 PK04_094193 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J16 compound treatment 1.21759594E8 -4.55E7 -1.19 1.19977982E8 -3.47E7 -0.98 -1.5344 -0.9953 3089773 PK04_094194 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J17 compound treatment 1.08487968E8 -5.88E7 -1.54 1.11526886E8 -4.32E7 -1.22 -1.9485 -0.9933 3186732 PK04_094195 CN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J18 compound treatment 1.15375753E8 -5.19E7 -1.36 1.13934838E8 -4.08E7 -1.15 -1.773 -0.9966 3089774 PK04_094196 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J19 compound treatment 1.1769557E8 -4.96E7 -1.3 1.14480666E8 -4.02E7 -1.13 -1.7192 -0.9978 3186733 PK04_094197 CCCN1C(=O)[C@@]2(Cc3ccccc13)N=C(O[C@H]2c4ccccc4)c5ccc(OCCCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J20 compound treatment 1.1046202E8 -5.68E7 -1.49 1.10757132E8 -4.4E7 -1.24 -1.9273 -0.9959 3089775 PK04_094198 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J21 mock treatment 1.70719062E8 3470000.0 0.09 1.60927348E8 6200000.0 0.17 0.1878 0.9535 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J22 mock treatment 1.80608885E8 1.34E7 0.35 1.64235656E8 9510000.0 0.27 0.4368 0.9914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J23 compound treatment 2.01487859E8 3.42E7 0.9 1.84079069E8 2.94E7 0.83 1.2186 0.9992 3068619 PK04_094199 COC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 J24 compound treatment 1.17538176E8 -4.97E7 -1.3 1.11379983E8 -4.33E7 -1.22 -1.7839 -0.9995 3089828 PK04_094200 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K01 compound treatment 1.25802874E8 -4.14E7 -1.08 1.52989566E8 -1740000.0 -0.05 -0.8018 -0.7383 3068620 PK04_094201 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K02 compound treatment 1.2755222E8 -3.97E7 -1.04 1.19691663E8 -3.5E7 -0.99 -1.4329 -0.9997 3186736 PK04_094202 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K03 compound treatment 1.12282538E8 -5.5E7 -1.44 1.02238709E8 -5.25E7 -1.48 -2.0633 -0.9999 3186737 PK04_094203 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K04 compound treatment 1.78284529E8 1.1E7 0.29 1.64111863E8 9390000.0 0.26 0.3913 0.999 3068660 PK04_094204 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K05 compound treatment 1.46709417E8 -2.05E7 -0.54 1.33586234E8 -2.11E7 -0.6 -0.8015 -0.9987 3186738 PK04_094205 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K06 compound treatment 1.49020352E8 -1.82E7 -0.48 1.45085904E8 -9640000.0 -0.27 -0.5295 -0.9643 3068661 PK04_094206 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K07 mock treatment 1.60099775E8 -7150000.0 -0.19 1.46452769E8 -8270000.0 -0.23 -0.2972 -0.9941 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K08 mock treatment 1.66972359E8 -278000.0 -0.01 1.43672419E8 -1.11E7 -0.31 -0.2254 -0.7234 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K09 compound treatment 9.7708975E7 -6.95E7 -1.82 9.357323E7 -6.12E7 -1.72 -2.5058 -0.9996 3186739 PK04_094207 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K10 compound treatment 1.49148944E8 -1.81E7 -0.47 1.32882714E8 -2.18E7 -0.62 -0.7703 -0.9916 3186740 PK04_094208 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K11 compound treatment 9.326157E7 -7.4E7 -1.94 9.4623678E7 -6.01E7 -1.69 -2.5672 -0.9978 3068664 PK04_094209 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K12 compound treatment 1.03711443E8 -6.35E7 -1.66 1.09014728E8 -4.57E7 -1.29 -2.087 -0.992 3186741 PK04_094210 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K13 compound treatment 9.6921876E7 -7.03E7 -1.84 9.7041862E7 -5.77E7 -1.63 -2.4512 -0.9981 3068666 PK04_094211 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K14 compound treatment 5.024738E7 -1.17E8 -3.06 6.4656014E7 -9.01E7 -2.54 -3.9605 -0.9956 3186742 PK04_094212 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K15 mock treatment 1.41708402E8 -2.55E7 -0.67 1.3119204E8 -2.35E7 -0.66 -0.9417 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K16 mock treatment 1.4706356E8 -2.02E7 -0.53 1.35406023E8 -1.93E7 -0.54 -0.7586 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K17 compound treatment 1.20157594E8 -4.71E7 -1.23 1.20763445E8 -3.4E7 -0.96 -1.5484 -0.9922 3186743 PK04_094213 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K18 compound treatment 7.8658498E7 -8.86E7 -2.32 7.6571966E7 -7.82E7 -2.2 -3.1972 -0.9997 3068667 PK04_094214 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K19 compound treatment 1.46874926E8 -2.04E7 -0.53 1.42531034E8 -1.22E7 -0.34 -0.6202 -0.9774 3186744 PK04_094215 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K20 compound treatment 9.3342232E7 -7.39E7 -1.93 1.02340281E8 -5.24E7 -1.48 -2.4119 -0.9911 3186745 PK04_094216 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K21 compound treatment 1.58625437E8 -8620000.0 -0.23 1.47251045E8 -7480000.0 -0.21 -0.3086 -0.9994 3068668 PK04_094217 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K22 compound treatment 1.57222896E8 -1.0E7 -0.26 1.52498863E8 -2230000.0 -0.06 -0.23 -0.8522 3186746 PK04_094218 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K23 mock treatment 1.8190289E8 1.47E7 0.38 1.60498667E8 5770000.0 0.16 0.3862 0.9271 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 K24 mock treatment 2.0090566E8 3.37E7 0.88 1.85606851E8 3.09E7 0.87 1.2383 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L01 compound treatment 2.14168352E8 4.69E7 1.23 1.89399814E8 3.47E7 0.98 1.5594 0.9936 3068669 PK04_094219 CCOC(=O)N1C(N=C(N1C(=O)OCC)c2ccc(OCCCO)cc2)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L02 compound treatment 8.7228673E7 -8.0E7 -2.09 5.7668053E7 -9.71E7 -2.74 -3.4152 -0.9913 3001020 PK04_094220 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L03 compound treatment 1.61335943E8 -5910000.0 -0.15 1.47441519E8 -7290000.0 -0.21 -0.2546 -0.9903 3068670 PK04_094221 COCCCNC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L04 compound treatment 7.962771E7 -8.76E7 -2.29 6.1433096E7 -9.33E7 -2.63 -3.4809 -0.9977 3089829 PK04_094222 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L05 compound treatment 1.68264854E8 1010000.0 0.03 1.65325558E8 1.06E7 0.3 0.23 0.767 3186813 PK04_094223 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L06 compound treatment 1.09635757E8 -5.76E7 -1.51 1.14261268E8 -4.05E7 -1.14 -1.8728 -0.9905 3001022 PK04_094224 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L07 mock treatment 1.59981616E8 -7270000.0 -0.19 1.46849638E8 -7880000.0 -0.22 -0.2915 -0.9971 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L08 mock treatment 1.5530272E8 -1.19E7 -0.31 1.47289532E8 -7440000.0 -0.21 -0.3693 -0.9811 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L09 compound treatment 1.54507279E8 -1.27E7 -0.33 1.36749481E8 -1.8E7 -0.51 -0.5941 -0.9794 3067926 PK04_094225 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L10 compound treatment 1.16023053E8 -5.12E7 -1.34 1.07323023E8 -4.74E7 -1.34 -1.8928 -1.0 3089768 PK04_094226 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L11 compound treatment 1.43812999E8 -2.34E7 -0.61 1.24699428E8 -3.0E7 -0.85 -1.0322 -0.9875 3186815 PK04_094227 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L12 compound treatment 1.01369623E8 -6.59E7 -1.72 9.9109963E7 -5.56E7 -1.57 -2.3277 -0.9989 3089830 PK04_094228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L13 compound treatment 1.31813958E8 -3.54E7 -0.93 1.27937006E8 -2.68E7 -0.75 -1.1897 -0.9948 3067927 PK04_094229 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L14 compound treatment 1.16030414E8 -5.12E7 -1.34 1.09138357E8 -4.56E7 -1.28 -1.8565 -0.9998 3089831 PK04_094230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L15 mock treatment 1.13022449E8 -5.42E7 -1.42 1.08978399E8 -4.57E7 -1.29 -1.9153 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L16 mock treatment 1.47471668E8 -1.98E7 -0.52 1.25140247E8 -2.96E7 -0.83 -0.9556 -0.9737 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L17 compound treatment 8.5782294E7 -8.15E7 -2.13 7.8756026E7 -7.6E7 -2.14 -3.0218 -1.0 3067928 PK04_094231 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L18 compound treatment 1.17928503E8 -4.93E7 -1.29 1.15478166E8 -3.92E7 -1.11 -1.695 -0.997 3001180 PK04_094232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L19 compound treatment 1.5533181E8 -1.19E7 -0.31 1.45104682E8 -9620000.0 -0.27 -0.4123 -0.9976 3067929 PK04_094233 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L20 compound treatment 1.38096946E8 -2.92E7 -0.76 1.29574912E8 -2.52E7 -0.71 -1.0408 -0.9993 3001092 PK04_094234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L21 compound treatment 1.58285043E8 -8960000.0 -0.23 1.5238577E8 -2340000.0 -0.07 -0.2126 -0.8721 3067930 PK04_094235 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L22 compound treatment 1.05942148E8 -6.13E7 -1.6 1.00625086E8 -5.41E7 -1.52 -2.2129 -0.9997 3001093 PK04_094236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L23 mock treatment 1.77542814E8 1.03E7 0.27 1.70345351E8 1.56E7 0.44 0.5017 0.9723 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 L24 mock treatment 2.0373607E8 3.65E7 0.96 1.86927103E8 3.22E7 0.91 1.317 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M01 compound treatment 7.1325765E7 -9.59E7 -2.51 6.2290122E7 -9.24E7 -2.6 -3.6175 -0.9998 3067931 PK04_094237 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M02 compound treatment 1.29692833E8 -3.76E7 -0.98 1.36970412E8 -1.78E7 -0.5 -1.049 -0.9509 3186821 PK04_094238 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M03 compound treatment 1.36662864E8 -3.06E7 -0.8 1.34512615E8 -2.02E7 -0.57 -0.969 -0.9861 3067933 PK04_094239 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M04 compound treatment 1.6361976E8 -3630000.0 -0.1 1.59860914E8 5130000.0 0.14 0.0351 0.2028 3186822 PK04_094240 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCCN3CCOCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M05 compound treatment 1.8298702E8 1.57E7 0.41 1.68353248E8 1.36E7 0.38 0.5628 0.9994 3067934 PK04_094241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M06 compound treatment 1.54254259E8 -1.3E7 -0.34 1.45825117E8 -8900000.0 -0.25 -0.4179 -0.9888 3186823 PK04_094242 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M07 compound treatment 6.166133E7 -1.06E8 -2.76 7.5383662E7 -7.93E7 -2.24 -3.5355 -0.9945 3186824 PK04_094243 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M08 compound treatment 7.8257688E7 -8.9E7 -2.33 8.6123967E7 -6.86E7 -1.93 -3.0142 -0.9957 3186825 PK04_094244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M09 mock treatment 1.70853389E8 3600000.0 0.09 1.44782932E8 -9940000.0 -0.28 -0.1314 -0.4446 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M10 mock treatment 1.49719135E8 -1.75E7 -0.46 1.3659767E8 -1.81E7 -0.51 -0.6857 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M11 compound treatment 6.8777631E7 -9.85E7 -2.58 7.6818851E7 -7.79E7 -2.2 -3.3751 -0.9968 3067981 PK04_094245 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M12 compound treatment 1.50478317E8 -1.68E7 -0.44 1.32542751E8 -2.22E7 -0.63 -0.7525 -0.985 3186826 PK04_094246 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M13 mock treatment 1.29324815E8 -3.79E7 -0.99 1.28028254E8 -2.67E7 -0.75 -1.234 -0.9906 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M14 mock treatment 1.19913265E8 -4.73E7 -1.24 1.15595538E8 -3.91E7 -1.1 -1.6559 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M15 compound treatment 4.94465E7 -1.18E8 -3.08 4.9789269E7 -1.05E8 -2.96 -4.2716 -0.9998 3067982 PK04_094247 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M16 compound treatment 5.3676638E7 -1.14E8 -2.97 5.7488171E7 -9.72E7 -2.74 -4.0398 -0.9992 3186827 PK04_094248 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M17 compound treatment 1.23685236E8 -4.36E7 -1.14 1.19746504E8 -3.5E7 -0.99 -1.5034 -0.9974 3067983 PK04_094249 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M18 compound treatment 1.20685544E8 -4.66E7 -1.22 1.180242E8 -3.67E7 -1.03 -1.5933 -0.9967 3186828 PK04_094250 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M19 compound treatment 1.15970968E8 -5.13E7 -1.34 1.14458125E8 -4.03E7 -1.13 -1.7516 -0.9965 3186829 PK04_094251 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M20 compound treatment 1.32318394E8 -3.49E7 -0.91 1.34341088E8 -2.04E7 -0.57 -1.0528 -0.9749 3067984 PK04_094252 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M21 compound treatment 1.65810422E8 -1440000.0 -0.04 1.55803055E8 1080000.0 0.03 -0.0052 -0.1075 3186907 PK04_094253 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M22 compound treatment 9.9710478E7 -6.75E7 -1.77 1.062659E8 -4.85E7 -1.37 -2.2158 -0.9919 3067985 PK04_094254 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M23 compound treatment 1.19563203E8 -4.77E7 -1.25 1.17653122E8 -3.71E7 -1.04 -1.6214 -0.9961 3186908 PK04_094255 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 M24 compound treatment 1.74094414E8 6840000.0 0.18 1.55621919E8 895000.0 0.03 0.1445 0.7988 3186909 PK04_094256 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N01 compound treatment 2.23925111E8 5.67E7 1.48 2.04309522E8 4.96E7 1.4 2.0371 0.9996 3067986 PK04_094257 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N02 compound treatment 1.70144889E8 2890000.0 0.08 1.62329705E8 7600000.0 0.21 0.2051 0.9024 3186910 PK04_094258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N03 compound treatment 1.63730219E8 -3520000.0 -0.09 1.59673074E8 4950000.0 0.14 0.0334 0.2 3067987 PK04_094259 CN(C)C(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N04 compound treatment 1.70241943E8 2990000.0 0.08 1.6515365E8 1.04E7 0.29 0.2632 0.8654 3186911 PK04_094260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N05 compound treatment 1.56857004E8 -1.04E7 -0.27 1.47968748E8 -6760000.0 -0.19 -0.327 -0.9848 3414052 PK04_094261 COC(=O)[C@@H]1N=C(O[C@@H]1C)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N06 compound treatment 1.56432216E8 -1.08E7 -0.28 1.46353657E8 -8370000.0 -0.24 -0.3671 -0.9959 3186912 PK04_094262 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N07 compound treatment 1.44354308E8 -2.29E7 -0.6 1.35458857E8 -1.93E7 -0.54 -0.8077 -0.9988 3186913 PK04_094263 OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N08 compound treatment 1.43049101E8 -2.42E7 -0.63 1.25538067E8 -2.92E7 -0.82 -1.0296 -0.9917 1952953 PK04_094264 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N09 mock treatment 1.47815344E8 -1.94E7 -0.51 1.31174921E8 -2.36E7 -0.66 -0.829 -0.9914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N10 mock treatment 1.36638249E8 -3.06E7 -0.8 1.32388688E8 -2.23E7 -0.63 -1.0117 -0.9929 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N11 compound treatment 1.43456717E8 -2.38E7 -0.62 1.22672537E8 -3.21E7 -0.9 -1.0791 -0.9835 3068027 PK04_094265 CC(=O)OC[C@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N12 compound treatment 1.10023741E8 -5.72E7 -1.5 9.7081601E7 -5.76E7 -1.62 -2.2079 -0.9992 3186914 PK04_094266 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N13 mock treatment 1.04124797E8 -6.31E7 -1.65 1.09510134E8 -4.52E7 -1.27 -2.0694 -0.9918 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N14 mock treatment 1.22715991E8 -4.45E7 -1.17 1.14470219E8 -4.03E7 -1.13 -1.6265 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N15 compound treatment 1.41688476E8 -2.56E7 -0.67 1.10856987E8 -4.39E7 -1.24 -1.3473 -0.9584 3068028 PK04_094267 CC(=O)OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N16 compound treatment 8.8598059E7 -7.87E7 -2.06 7.8162005E7 -7.66E7 -2.16 -2.9815 -0.9997 3186915 PK04_094268 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N17 compound treatment 1.61092666E8 -6160000.0 -0.16 1.40509187E8 -1.42E7 -0.4 -0.3973 -0.9199 3068029 PK04_094269 CC(=O)OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N18 compound treatment 9.7188827E7 -7.01E7 -1.83 9.1632657E7 -6.31E7 -1.78 -2.5541 -0.9999 1952947 PK04_094270 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@@H](Cc5ccccc5)C/C=C/C[C@H](Cc6ccccc6)C(=O)O[C@@H]14 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N19 compound treatment 1.51249472E8 -1.6E7 -0.42 1.45186566E8 -9540000.0 -0.27 -0.4863 -0.977 3068030 PK04_094271 OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N20 compound treatment 9.1745315E7 -7.55E7 -1.98 8.386745E7 -7.09E7 -2.0 -2.8096 -1.0 3186916 PK04_094272 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N21 compound treatment 1.68083532E8 834000.0 0.02 1.48198276E8 -6530000.0 -0.18 -0.1147 -0.6189 3068031 PK04_094273 CC(=O)OC[C@@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N22 compound treatment 6.9902436E7 -9.73E7 -2.55 6.5872058E7 -8.89E7 -2.5 -3.5724 -1.0 1952944 PK04_094274 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N23 compound treatment 1.72334627E8 5080000.0 0.13 1.54455423E8 -271000.0 -0.01 0.0887 0.6654 3186917 PK04_094275 CC(=O)OC[C@H](C=C)N(Cc1ccc(cc1)[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 N24 compound treatment 2.14850854E8 4.76E7 1.25 2.01402627E8 4.67E7 1.32 1.8112 0.9996 3413982 PK04_094276 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O01 compound treatment 6.713506E7 -1.0E8 -2.62 6.67866E7 -8.79E7 -2.48 -3.6054 -0.9996 3068032 PK04_094277 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O02 compound treatment 9.1913495E7 -7.53E7 -1.97 9.3706208E7 -6.1E7 -1.72 -2.6104 -0.9977 3186919 PK04_094278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O03 compound treatment 1.89568507E8 2.23E7 0.58 1.60941135E8 6210000.0 0.18 0.5369 0.8804 3068033 PK04_094279 NC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O04 compound treatment 1.48160431E8 -1.91E7 -0.5 1.43806872E8 -1.09E7 -0.31 -0.5709 -0.9729 3186920 PK04_094280 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O05 compound treatment 6.0044305E7 -1.07E8 -2.81 5.1864047E7 -1.03E8 -2.9 -4.0341 -0.9999 3068035 PK04_094281 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O06 compound treatment 1.53952215E8 -1.33E7 -0.35 1.35378129E8 -1.93E7 -0.55 -0.6317 -0.9765 3186921 PK04_094282 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O07 compound treatment 9.8341463E7 -6.89E7 -1.8 9.8059124E7 -5.67E7 -1.6 -2.4047 -0.9982 3186922 PK04_094283 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O08 compound treatment 1.51812762E8 -1.54E7 -0.4 1.31982091E8 -2.27E7 -0.64 -0.739 -0.9753 3068037 PK04_094284 CN(C)C(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O09 compound treatment 9.774991E7 -6.95E7 -1.82 9.3783069E7 -6.09E7 -1.72 -2.5008 -0.9996 3186923 PK04_094285 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O10 compound treatment 9.0709592E7 -7.65E7 -2.0 9.1646161E7 -6.31E7 -1.78 -2.6737 -0.9982 3068038 PK04_094286 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O11 mock treatment 1.47891083E8 -1.94E7 -0.51 1.22309344E8 -3.24E7 -0.91 -1.0043 -0.9613 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O12 mock treatment 1.11932328E8 -5.53E7 -1.45 9.3982258E7 -6.07E7 -1.71 -2.2343 -0.9965 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O13 compound treatment 1.47720852E8 -1.95E7 -0.51 1.13787812E8 -4.09E7 -1.15 -1.1773 -0.9329 3186924 PK04_094287 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O14 compound treatment 1.06441628E8 -6.08E7 -1.59 1.03307851E8 -5.14E7 -1.45 -2.1502 -0.9989 3186925 PK04_094288 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O15 compound treatment 1.55926502E8 -1.13E7 -0.3 1.09229198E8 -4.55E7 -1.28 -1.1162 -0.8482 3187013 PK04_094289 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O16 compound treatment 1.04305937E8 -6.29E7 -1.65 9.5024421E7 -5.97E7 -1.68 -2.3547 -0.9999 3068077 PK04_094290 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O17 compound treatment 1.20558788E8 -4.67E7 -1.22 1.11823271E8 -4.29E7 -1.21 -1.7192 -1.0 3187014 PK04_094291 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O18 compound treatment 9.9738713E7 -6.75E7 -1.77 9.966394E7 -5.51E7 -1.55 -2.3468 -0.9979 3187015 PK04_094292 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O19 compound treatment 1.56584908E8 -1.07E7 -0.28 1.41546794E8 -1.32E7 -0.37 -0.46 -0.9901 3068081 PK04_094293 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O20 compound treatment 1.48287928E8 -1.9E7 -0.5 1.37896564E8 -1.68E7 -0.47 -0.6864 -0.9997 3187016 PK04_094294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O21 compound treatment 1.70867871E8 3620000.0 0.09 1.57072126E8 2350000.0 0.07 0.1137 0.9845 3187017 PK04_094295 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O22 compound treatment 8.7367711E7 -7.99E7 -2.09 9.1150065E7 -6.36E7 -1.79 -2.7455 -0.997 3068083 PK04_094296 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O23 compound treatment 1.41789719E8 -2.55E7 -0.67 1.39423417E8 -1.53E7 -0.43 -0.7762 -0.9778 3187018 PK04_094297 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 O24 compound treatment 1.64533032E8 -2720000.0 -0.07 1.51383571E8 -3340000.0 -0.09 -0.1169 -0.9904 3068084 PK04_094298 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P01 compound treatment 1.16483336E8 -5.08E7 -1.33 1.09866727E8 -4.49E7 -1.26 -1.8336 -0.9997 3187019 PK04_094299 CC(=O)OC[C@H](C=C)N(Cc1ccccc1[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P02 compound treatment 1.9584317E8 2.86E7 0.75 1.81822915E8 2.71E7 0.76 1.0692 1.0 3413984 PK04_094300 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P03 compound treatment 2.00202106E8 3.3E7 0.86 1.84810282E8 3.01E7 0.85 1.2094 1.0 3068086 PK04_094301 COc1ccc(CN([C@H](CO)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P04 compound treatment 1.52751999E8 -1.45E7 -0.38 1.44121108E8 -1.06E7 -0.3 -0.4797 -0.993 3413986 PK04_094302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P05 compound treatment 1.84579936E8 1.73E7 0.45 1.58331171E8 3600000.0 0.1 0.3926 0.8445 3068087 PK04_094303 COc1cc(CN([C@@H](COC(=O)C)C=C)S(=O)(=O)c2ccc(Br)cc2)ccc1OC(=O)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P06 compound treatment 1.17058511E8 -5.02E7 -1.31 9.6764546E7 -5.8E7 -1.63 -2.084 -0.9942 1952975 PK04_094304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P07 compound treatment 1.71858999E8 4610000.0 0.12 1.42516824E8 -1.22E7 -0.34 -0.158 -0.4333 3068088 PK04_094305 OCCCNS(=O)(=O)c1ccc(Br)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P08 compound treatment 8.6894435E7 -8.04E7 -2.1 8.3537706E7 -7.12E7 -2.01 -2.9059 -0.9997 3413993 PK04_094306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P09 compound treatment 1.75868282E8 8620000.0 0.23 1.39288092E8 -1.54E7 -0.44 -0.1481 -0.3022 3068089 PK04_094307 CC[Si](CC)(CC)OC[C@@H](C=C)N(Cc1ccc(OC(=O)C)c(OC)c1)S(=O)(=O)c2ccc(Br)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P10 compound treatment 1.32907503E8 -3.43E7 -0.9 1.06881429E8 -4.78E7 -1.35 -1.5891 -0.9806 1952969 PK04_094308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5ccccc5)C/C=C/C[C@@H](Cc6ccccc6)C(=O)O[C@@H]14 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P11 mock treatment 1.58875187E8 -8370000.0 -0.22 1.35301287E8 -1.94E7 -0.55 -0.5421 -0.9193 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P12 mock treatment 1.62672737E8 -4580000.0 -0.12 1.3002123E8 -2.47E7 -0.7 -0.577 -0.8168 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P13 compound treatment 1.53119486E8 -1.41E7 -0.37 1.27664281E8 -2.71E7 -0.76 -0.8008 -0.9448 3068090 PK04_094309 COc1cc(CO)ccc1OC(=O)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P14 compound treatment 1.64080189E8 -3170000.0 -0.08 1.30031295E8 -2.47E7 -0.7 -0.5508 -0.7858 3068091 PK04_094310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P15 compound treatment 1.49761774E8 -1.75E7 -0.46 1.30900758E8 -2.38E7 -0.67 -0.7985 -0.9826 3187025 PK04_094311 COc1ccc(CN(C2=CC[C@@]3(C(=O)N)C(=O)C(=C(Cl)C(=O)[C@]3(C2)C#N)Cl)S(=O)(=O)c4ccc(Br)cc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P16 compound treatment 1.5849691E8 -8750000.0 -0.23 1.41979661E8 -1.27E7 -0.36 -0.416 -0.9764 3187026 PK04_094312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P17 compound treatment 1.52053019E8 -1.52E7 -0.4 1.3285484E8 -2.19E7 -0.62 -0.7171 -0.9776 3068092 PK04_094313 CC(C)(C)OC(=O)N1[C@H](COC1(C)C)C=C(Br)Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P18 compound treatment 1.51956136E8 -1.53E7 -0.4 1.35790154E8 -1.89E7 -0.53 -0.6604 -0.99 3187027 PK04_094314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P19 compound treatment 1.60590136E8 -6660000.0 -0.17 1.50017808E8 -4710000.0 -0.13 -0.2171 -0.9909 1003211 PK04_094315 CNS(=O)(=O)c1ccc(C)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P20 compound treatment 1.5703147E8 -1.02E7 -0.27 1.32505798E8 -2.22E7 -0.63 -0.6319 -0.928 3187028 PK04_094316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P21 compound treatment 7.0664684E7 -9.66E7 -2.53 7.3951428E7 -8.08E7 -2.28 -3.3973 -0.9986 3068127 PK04_094317 COc1cc(COC(=O)C)ccc1OC(=O)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P22 compound treatment 1.63416126E8 -3830000.0 -0.1 1.57165599E8 2440000.0 0.07 -0.0224 -0.1839 3187029 PK04_094318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P23 compound treatment 2.07127779E8 3.99E7 1.04 1.86046428E8 3.13E7 0.88 1.3622 0.9965 3068129 PK04_094319 OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2094 P24 compound treatment 2.36366986E8 6.91E7 1.81 2.19021809E8 6.43E7 1.81 2.5605 1.0 3413981 PK04_094320 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A01 compound treatment 2.35337421E8 8.21E7 2.15 2.3253814E8 7.32E7 2.06 2.9772 0.9998 3067957 PK04_095001 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A02 compound treatment 2.13827498E8 6.06E7 1.59 2.153308E8 5.6E7 1.58 2.2362 1.0 3187176 PK04_095002 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A03 compound treatment 1.44611737E8 -8640000.0 -0.23 1.53851709E8 -5520000.0 -0.16 -0.2701 -0.9833 3067577 PK04_095003 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A04 compound treatment 1.40044781E8 -1.32E7 -0.35 1.43241163E8 -1.61E7 -0.45 -0.566 -0.9909 3187436 PK04_095004 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A05 compound treatment 1.45120996E8 -8130000.0 -0.21 1.43376329E8 -1.6E7 -0.45 -0.4694 -0.9414 3186425 PK04_095005 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6I)c7ccc(cc7)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A06 compound treatment 1.87609288E8 3.44E7 0.9 1.93964627E8 3.46E7 0.97 1.3251 0.9992 3187069 PK04_095006 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A07 compound treatment 1.87973769E8 3.47E7 0.91 1.90427544E8 3.11E7 0.88 1.2614 0.9998 3187427 PK04_095007 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A08 compound treatment 8.2856111E7 -7.04E7 -1.84 8.1327453E7 -7.8E7 -2.2 -2.8583 -0.9961 3187515 PK04_095008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6)c7ccc(cc7)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A09 compound treatment 1.81209866E8 2.8E7 0.73 1.83135777E8 2.38E7 0.67 0.9909 0.999 3187425 PK04_095009 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A10 compound treatment 1.68052987E8 1.48E7 0.39 1.8325097E8 2.39E7 0.67 0.7497 0.9656 3068592 PK04_095010 CCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A11 compound treatment 1.19058674E8 -3.42E7 -0.9 1.52283971E8 -7090000.0 -0.2 -0.7743 -0.8442 3187517 PK04_095011 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A12 compound treatment 1.77296892E8 2.4E7 0.63 1.99012533E8 3.96E7 1.12 1.2348 0.9632 3187344 PK04_095012 COCCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A13 mock treatment 1.89086919E8 3.58E7 0.94 2.01750954E8 4.24E7 1.19 1.5076 0.9929 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A14 mock treatment 1.69840869E8 1.66E7 0.43 1.8284903E8 2.35E7 0.66 0.7747 0.9791 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A15 compound treatment 1.60686826E8 7430000.0 0.19 1.81463729E8 2.21E7 0.62 0.5777 0.8858 3186552 PK04_095013 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A16 compound treatment 1.8871668E8 3.55E7 0.93 1.93126389E8 3.38E7 0.95 1.3289 0.9999 3187439 PK04_095014 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A17 compound treatment 1.83357508E8 3.01E7 0.79 1.83125858E8 2.38E7 0.67 1.0304 0.9967 3187073 PK04_095015 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A18 compound treatment 1.9351821E8 4.03E7 1.05 2.0178622E8 4.24E7 1.2 1.5904 0.998 3187272 PK04_095016 COCCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A19 compound treatment 1.88313676E8 3.51E7 0.92 1.97588466E8 3.82E7 1.08 1.4104 0.9968 3187508 PK04_095017 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NC3CC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A20 compound treatment 1.7534271E8 2.21E7 0.58 1.7134378E8 1.2E7 0.34 0.6473 0.9671 3186432 PK04_095018 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A21 compound treatment 1.62155488E8 8900000.0 0.23 1.567043E8 -2670000.0 -0.08 0.1115 0.4555 3068646 PK04_095019 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A22 compound treatment 2.00213455E8 4.7E7 1.23 2.00152868E8 4.08E7 1.15 1.6817 0.9994 3068651 PK04_095020 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A23 compound treatment 2.0658052E8 5.33E7 1.4 2.10957893E8 5.16E7 1.45 2.0149 0.9998 3187585 PK04_095021 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 A24 compound treatment 2.23945339E8 7.07E7 1.85 2.19647996E8 6.03E7 1.7 2.5095 0.9991 3187430 PK04_095022 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B01 compound treatment 1.18555852E8 -3.47E7 -0.91 1.21505327E8 -3.79E7 -1.07 -1.3969 -0.9968 3187519 PK04_095023 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B02 compound treatment 1.87192431E8 3.39E7 0.89 1.95844936E8 3.65E7 1.03 1.3549 0.9974 3186885 PK04_095024 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B03 compound treatment 1.74806027E8 2.16E7 0.56 1.79642576E8 2.03E7 0.57 0.8028 1.0 3187435 PK04_095025 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B04 compound treatment 1.53404906E8 149000.0 0.0 1.64557331E8 5180000.0 0.15 0.106 0.7258 3186491 PK04_095026 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B05 compound treatment 1.78252519E8 2.5E7 0.65 1.74197115E8 1.48E7 0.42 0.758 0.9765 3068539 PK04_095027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(F)cc(c4)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B06 compound treatment 1.38025491E8 -1.52E7 -0.4 1.32799797E8 -2.66E7 -0.75 -0.8115 -0.9564 3186559 PK04_095028 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B07 compound treatment 1.74018146E8 2.08E7 0.54 1.71492612E8 1.21E7 0.34 0.6258 0.9749 3068561 PK04_095029 CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B08 compound treatment 9.1095456E7 -6.22E7 -1.63 9.7739609E7 -6.16E7 -1.74 -2.3788 -0.9995 3068322 PK04_095030 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B09 compound treatment 1.60583124E8 7330000.0 0.19 1.67955805E8 8580000.0 0.24 0.3066 0.9934 3187432 PK04_095031 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B10 compound treatment 1.27247757E8 -2.6E7 -0.68 1.271638E8 -3.22E7 -0.91 -1.1233 -0.9899 3068145 PK04_095032 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(F)(F)F)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B11 compound treatment 1.47828425E8 -5430000.0 -0.14 1.63857194E8 4480000.0 0.13 -0.0111 -0.0586 3187265 PK04_095033 CC(C)N1[C@H]([C@H](C(=O)NCCCN(C)C)c2ccccc2C1=O)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B12 compound treatment 1.46989434E8 -6270000.0 -0.16 1.69513935E8 1.01E7 0.29 0.086 0.2612 3186629 PK04_095034 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B13 mock treatment 1.50206155E8 -3050000.0 -0.08 1.64811931E8 5440000.0 0.15 0.0519 0.3004 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B14 mock treatment 1.51666262E8 -1590000.0 -0.04 1.6616912E8 6790000.0 0.19 0.106 0.5408 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B15 compound treatment 1.57667979E8 4410000.0 0.12 1.72469764E8 1.31E7 0.37 0.3426 0.8861 3187269 PK04_095035 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3CCCCC3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B16 compound treatment 1.58883303E8 5630000.0 0.15 1.6597435E8 6600000.0 0.19 0.2357 0.9933 3186887 PK04_095036 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B17 compound treatment 1.49907967E8 -3350000.0 -0.09 1.69763569E8 1.04E7 0.29 0.145 0.4746 3068417 PK04_095037 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B18 compound treatment 1.60206894E8 6950000.0 0.18 1.7748795E8 1.81E7 0.51 0.4896 0.9035 3067610 PK04_095038 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(C7CC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B19 compound treatment 1.33829446E8 -1.94E7 -0.51 1.64627328E8 5250000.0 0.15 -0.2549 -0.4813 3068639 PK04_095039 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B20 compound treatment 1.77501765E8 2.42E7 0.63 1.8094612E8 2.16E7 0.61 0.8786 0.9998 3068006 PK04_095040 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B21 compound treatment 1.67534943E8 1.43E7 0.37 1.80640487E8 2.13E7 0.6 0.6881 0.9742 3068601 PK04_095041 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCc4ccccc4)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B22 compound treatment 1.65483448E8 1.22E7 0.32 1.68900113E8 9520000.0 0.27 0.4161 0.9962 3068203 PK04_095042 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5Cl)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B23 compound treatment 1.8128183E8 2.8E7 0.73 1.84907804E8 2.55E7 0.72 1.0275 1.0 3187355 PK04_095043 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCC(F)(F)F)c4ccccc4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 B24 compound treatment 2.0565572E8 5.24E7 1.37 2.07858797E8 4.85E7 1.37 1.936 1.0 3068156 PK04_095044 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C01 compound treatment 2.07641976E8 5.44E7 1.42 2.02934139E8 4.36E7 1.23 1.8747 0.9973 3187590 PK04_095045 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C02 compound treatment 1.7542135E8 2.22E7 0.58 1.8627872E8 2.69E7 0.76 0.9464 0.9913 3187180 PK04_095046 CC(C)NC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C03 compound treatment 1.47345163E8 -5910000.0 -0.15 1.60067382E8 692000.0 0.02 -0.0956 -0.6131 3186493 PK04_095047 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C04 compound treatment 2.9586694E7 -1.24E8 -3.24 2.9160587E7 -1.3E8 -3.67 -4.8838 -0.998 3186427 PK04_095048 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C05 compound treatment 1.59605859E8 6350000.0 0.17 1.71508337E8 1.21E7 0.34 0.3593 0.9451 3187172 PK04_095049 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C06 compound treatment 1.57152035E8 3900000.0 0.1 1.67379966E8 8000000.0 0.23 0.2316 0.9356 3187080 PK04_095050 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C07 compound treatment 1.64184072E8 1.09E7 0.29 1.66903757E8 7530000.0 0.21 0.3523 0.9892 3186988 PK04_095051 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C08 compound treatment 8.8179038E7 -6.51E7 -1.7 9.2935261E7 -6.64E7 -1.87 -2.5285 -0.9989 3068011 PK04_095052 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C09 compound treatment 1.64672486E8 1.14E7 0.3 1.68423409E8 9050000.0 0.25 0.3916 0.9969 3068498 PK04_095053 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C10 compound treatment 3.0651694E7 -1.23E8 -3.21 3.1896139E7 -1.27E8 -3.59 -4.8096 -0.9984 3186550 PK04_095054 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C11 mock treatment 1.58855361E8 5600000.0 0.15 1.75277778E8 1.59E7 0.45 0.4205 0.8919 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C12 mock treatment 1.53363039E8 108000.0 0.0 1.67058417E8 7680000.0 0.22 0.1551 0.7162 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C13 compound treatment 1.53963691E8 708000.0 0.02 1.66223294E8 6850000.0 0.19 0.1496 0.7715 3187361 PK04_095055 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C14 compound treatment 1.6349774E8 1.02E7 0.27 1.68325557E8 8950000.0 0.25 0.3679 0.9995 3068504 PK04_095056 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C15 mock treatment 1.54178986E8 924000.0 0.02 1.60039779E8 664000.0 0.02 0.0303 0.992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C16 mock treatment 1.53117067E8 -138000.0 0.0 1.56942737E8 -2430000.0 -0.07 -0.051 -0.7434 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C17 compound treatment 1.61215764E8 7960000.0 0.21 1.73448237E8 1.41E7 0.4 0.4278 0.9549 3067969 PK04_095057 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCCN(C)C)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C18 compound treatment 1.36472561E8 -1.68E7 -0.44 1.23354873E8 -3.6E7 -1.02 -1.0284 -0.9298 3187359 PK04_095058 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C19 compound treatment 1.50435104E8 -2820000.0 -0.07 1.55708756E8 -3670000.0 -0.1 -0.1253 -0.9864 3187087 PK04_095059 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C20 compound treatment 1.61882495E8 8630000.0 0.23 1.61719809E8 2340000.0 0.07 0.2064 0.8772 3187443 PK04_095060 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C21 compound treatment 1.53906906E8 651000.0 0.02 1.6359949E8 4220000.0 0.12 0.0962 0.8002 3067571 PK04_095061 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C22 compound treatment 1.62115813E8 8860000.0 0.23 1.68413795E8 9040000.0 0.25 0.3441 0.9989 3187181 PK04_095062 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C23 compound treatment 1.61517293E8 8260000.0 0.22 1.70490834E8 1.11E7 0.31 0.3744 0.9836 3187509 PK04_095063 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)c4ccc(cc4)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 C24 compound treatment 1.90525979E8 3.73E7 0.98 2.03347455E8 4.4E7 1.24 1.5661 0.993 3068474 PK04_095064 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D01 compound treatment 1.80780882E8 2.75E7 0.72 1.76374859E8 1.7E7 0.48 0.8482 0.9803 3068587 PK04_095065 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(CC3(CC4CC5CC(C4)C3)C5)C(=O)c6ccccc26)c7ccc(CO)cc7)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D02 compound treatment 9.677707E7 -5.65E7 -1.48 9.9083234E7 -6.03E7 -1.7 -2.2468 -0.9976 3068318 PK04_095066 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D03 compound treatment 1.68088237E8 1.48E7 0.39 1.81826663E8 2.25E7 0.63 0.7219 0.9725 3187363 PK04_095067 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D04 compound treatment 1.60441065E8 7190000.0 0.19 1.62611139E8 3240000.0 0.09 0.1975 0.9447 3186486 PK04_095068 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CCN7CCOCC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D05 compound treatment 1.59635071E8 6380000.0 0.17 1.66148395E8 6770000.0 0.19 0.253 0.9978 3187179 PK04_095069 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(=O)c3ccccc23)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D06 compound treatment 1.33609705E8 -1.96E7 -0.51 1.34294173E8 -2.51E7 -0.71 -0.8634 -0.9878 3187522 PK04_095070 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D07 compound treatment 1.61011566E8 7760000.0 0.2 1.66196383E8 6820000.0 0.19 0.2795 0.9996 3068515 PK04_095071 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D08 compound treatment 1.57137948E8 3880000.0 0.1 1.67890007E8 8510000.0 0.24 0.2415 0.9269 3186872 PK04_095072 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D09 compound treatment 1.51547146E8 -1710000.0 -0.04 1.50591706E8 -8780000.0 -0.25 -0.2066 -0.8216 3068609 PK04_095073 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D10 compound treatment 8.5232155E7 -6.8E7 -1.78 8.5666247E7 -7.37E7 -2.08 -2.7279 -0.9971 3186795 PK04_095074 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D11 mock treatment 1.49522177E8 -3730000.0 -0.1 1.61251906E8 1880000.0 0.05 -0.0317 -0.2854 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D12 mock treatment 1.53868651E8 613000.0 0.02 1.64706688E8 5330000.0 0.15 0.1176 0.7782 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D13 compound treatment 1.54373054E8 1120000.0 0.03 1.67525914E8 8150000.0 0.23 0.1831 0.7908 3067964 PK04_095075 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D14 compound treatment 1.44736665E8 -8520000.0 -0.22 1.57743707E8 -1630000.0 -0.05 -0.1902 -0.8353 3068230 PK04_095076 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D15 mock treatment 1.50909942E8 -2350000.0 -0.06 1.63416221E8 4040000.0 0.11 0.0371 0.2868 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D16 mock treatment 1.59851881E8 6600000.0 0.17 1.65562963E8 6190000.0 0.17 0.2454 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D17 compound treatment 1.51340428E8 -1920000.0 -0.05 1.58745944E8 -629000.0 -0.02 -0.048 -0.9025 3068595 PK04_095077 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCc3ccccc3)c4ccccc4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D18 compound treatment 1.58079021E8 4820000.0 0.13 1.59473274E8 97900.0 0.0 0.0912 0.7224 3186982 PK04_095078 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D19 compound treatment 1.4490773E8 -8350000.0 -0.22 1.55791848E8 -3580000.0 -0.1 -0.2259 -0.9385 3187440 PK04_095079 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D20 compound treatment 1.56478893E8 3220000.0 0.08 1.62395921E8 3020000.0 0.09 0.1199 1.0 3068415 PK04_095080 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D21 compound treatment 1.53230585E8 -24900.0 0.0 1.65051604E8 5680000.0 0.16 0.1126 0.7042 3068596 PK04_095081 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCC(F)(F)F)c3ccccc3C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D22 compound treatment 9.2726916E7 -6.05E7 -1.58 1.01727544E8 -5.76E7 -1.62 -2.2691 -0.9999 3186713 PK04_095082 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D23 compound treatment 1.64082109E8 1.08E7 0.28 1.64816534E8 5440000.0 0.15 0.3088 0.9584 3187357 PK04_095083 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 D24 compound treatment 1.06016356E8 -4.72E7 -1.24 1.06887017E8 -5.25E7 -1.48 -1.9203 -0.996 3068270 PK04_095084 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCCN6CCOCC6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E01 mock treatment 2.01422054E8 4.82E7 1.26 2.1082693E8 5.15E7 1.45 1.9168 0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E02 mock treatment 1.84751684E8 3.15E7 0.82 1.93977979E8 3.46E7 0.98 1.2725 0.9965 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E03 compound treatment 1.82391403E8 2.91E7 0.76 1.84508077E8 2.51E7 0.71 1.0401 0.9993 3068636 PK04_095085 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E04 compound treatment 1.60614195E8 7360000.0 0.19 1.69506886E8 1.01E7 0.29 0.3381 0.9816 3186556 PK04_095086 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E05 compound treatment 1.55337556E8 2080000.0 0.05 1.65382556E8 6010000.0 0.17 0.1582 0.8898 3187587 PK04_095087 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E06 compound treatment 8.2602462E7 -7.07E7 -1.85 8.2509339E7 -7.69E7 -2.17 -2.8394 -0.9969 3186428 PK04_095088 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E07 compound treatment 1.52243072E8 -1010000.0 -0.03 1.57628432E8 -1750000.0 -0.05 -0.0535 -0.9578 3187266 PK04_095089 CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E08 compound treatment 1.53859944E8 604000.0 0.02 1.65881503E8 6510000.0 0.18 0.1408 0.7653 3187351 PK04_095090 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E09 mock treatment 1.57083069E8 3830000.0 0.1 1.64244055E8 4870000.0 0.14 0.1679 0.9881 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E10 mock treatment 1.54982423E8 1730000.0 0.05 1.6437243E8 5000000.0 0.14 0.1315 0.8894 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E11 compound treatment 1.45187684E8 -8070000.0 -0.21 1.61334024E8 1960000.0 0.06 -0.1103 -0.5053 3068004 PK04_095091 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E12 compound treatment 1.37256883E8 -1.6E7 -0.42 1.44709909E8 -1.47E7 -0.41 -0.5884 -1.0 3186500 PK04_095092 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E13 compound treatment 1.41271399E8 -1.2E7 -0.31 1.6052681E8 1150000.0 0.03 -0.1989 -0.6306 3187346 PK04_095093 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCN3CCOCC3)c4ccccc4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E14 compound treatment 1.3340182E8 -1.99E7 -0.52 1.61254012E8 1880000.0 0.05 -0.3301 -0.6318 3187262 PK04_095094 CC(C)N1[C@H]([C@H](C(=O)NCCN2CCOCC2)c3ccccc3C1=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E15 compound treatment 6.975657E7 -8.35E7 -2.19 8.7307319E7 -7.21E7 -2.03 -2.9816 -0.9993 3067574 PK04_095095 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E16 compound treatment 1.04476093E8 -4.88E7 -1.28 1.54421392E8 -4950000.0 -0.14 -1.0016 -0.7798 3187350 PK04_095096 COCCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E17 mock treatment 1.44650435E8 -8610000.0 -0.23 1.6075908E8 1380000.0 0.04 -0.1317 -0.5761 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E18 mock treatment 1.79881907E8 2.66E7 0.7 1.63267724E8 3890000.0 0.11 0.5704 0.8084 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E19 compound treatment 1.73884503E8 2.06E7 0.54 1.64036423E8 4660000.0 0.13 0.4747 0.8542 3068657 PK04_095097 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E20 compound treatment 1.49339661E8 -3920000.0 -0.1 1.43840732E8 -1.55E7 -0.44 -0.382 -0.8497 3068140 PK04_095098 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E21 compound treatment 1.61862587E8 8610000.0 0.23 1.57253985E8 -2120000.0 -0.06 0.117 0.5021 3186562 PK04_095099 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E22 compound treatment 1.76640823E8 2.34E7 0.61 1.76769555E8 1.74E7 0.49 0.7795 0.9939 3187591 PK04_095100 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E23 compound treatment 1.81925591E8 2.87E7 0.75 1.67109281E8 7730000.0 0.22 0.6848 0.8763 3187263 PK04_095101 CC(C)N1[C@H]([C@H](C(=O)NCc2ccccc2)c3ccccc3C1=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 E24 compound treatment 2.03960251E8 5.07E7 1.33 1.96734271E8 3.74E7 1.05 1.683 0.9934 3068517 PK04_095102 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F01 mock treatment 1.9200134E8 3.87E7 1.01 2.02136287E8 4.28E7 1.21 1.5693 0.9963 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F02 mock treatment 1.87192728E8 3.39E7 0.89 1.90226549E8 3.09E7 0.87 1.2429 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F03 compound treatment 1.77202349E8 2.39E7 0.63 1.79354315E8 2.0E7 0.56 0.8414 0.9986 3187079 PK04_095103 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F04 compound treatment 1.52948357E8 -307000.0 -0.01 1.58835774E8 -540000.0 -0.02 -0.0164 -0.9556 3068331 PK04_095104 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F05 compound treatment 1.58252312E8 5000000.0 0.13 1.59934041E8 559000.0 0.02 0.1036 0.7865 3068563 PK04_095105 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F06 compound treatment 1.55067636E8 1810000.0 0.05 1.60070705E8 695000.0 0.02 0.0474 0.9235 3186879 PK04_095106 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCCN6CCOCC6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F07 compound treatment 8.5042797E7 -6.82E7 -1.79 8.9250098E7 -7.01E7 -1.98 -2.66 -0.9987 3187523 PK04_095107 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F08 compound treatment 1.50675139E8 -2580000.0 -0.07 1.61886463E8 2510000.0 0.07 0.0023 0.0233 3186563 PK04_095108 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F09 mock treatment 1.54458992E8 1200000.0 0.03 1.6200712E8 2630000.0 0.07 0.0747 0.9273 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F10 mock treatment 1.47244069E8 -6010000.0 -0.16 1.52337193E8 -7040000.0 -0.2 -0.2515 -0.9934 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F11 compound treatment 1.54131458E8 876000.0 0.02 1.60162294E8 787000.0 0.02 0.0319 0.9999 3187257 PK04_095109 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F12 compound treatment 9.3240691E7 -6.0E7 -1.57 8.8094186E7 -7.13E7 -2.01 -2.5312 -0.9926 3068241 PK04_095110 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F13 compound treatment 1.44696946E8 -8560000.0 -0.22 1.53816813E8 -5560000.0 -0.16 -0.2692 -0.9847 3068554 PK04_095111 COCCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F14 compound treatment 1.49549636E8 -3710000.0 -0.1 1.57160905E8 -2210000.0 -0.06 -0.1127 -0.9772 3068362 PK04_095112 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)Sc4ccc(C)cc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F15 compound treatment 1.04596298E8 -4.87E7 -1.27 1.11763415E8 -4.76E7 -1.34 -1.8494 -0.9997 3186423 PK04_095113 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F16 compound treatment 1.42151767E8 -1.11E7 -0.29 1.46045432E8 -1.33E7 -0.38 -0.4711 -0.992 3068012 PK04_095114 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F17 mock treatment 1.50184619E8 -3070000.0 -0.08 1.60628031E8 1250000.0 0.04 -0.0319 -0.3631 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F18 mock treatment 1.54554929E8 1300000.0 0.03 1.62019161E8 2640000.0 0.07 0.0767 0.9369 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F19 compound treatment 1.09947062E8 -4.33E7 -1.13 1.18049413E8 -4.13E7 -1.16 -1.6251 -0.9999 3067568 PK04_095115 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F20 compound treatment 9.0361206E7 -6.29E7 -1.65 9.2269983E7 -6.71E7 -1.89 -2.5013 -0.9976 3068266 PK04_095116 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F21 compound treatment 1.25866319E8 -2.74E7 -0.72 1.29841557E8 -2.95E7 -0.83 -1.0955 -0.9972 3186419 PK04_095117 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F22 compound treatment 8.9509132E7 -6.37E7 -1.67 9.2065719E7 -6.73E7 -1.9 -2.5212 -0.998 3187524 PK04_095118 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F23 compound treatment 1.78194482E8 2.49E7 0.65 1.69533032E8 1.02E7 0.29 0.664 0.9315 3068017 PK04_095119 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)O)c4ccccc4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 F24 compound treatment 2.00166352E8 4.69E7 1.23 2.0246039E8 4.31E7 1.21 1.7268 1.0 3186554 PK04_095120 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G01 compound treatment 1.82235338E8 2.9E7 0.76 1.79520244E8 2.01E7 0.57 0.9378 0.9898 3186418 PK04_095121 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G02 compound treatment 1.8675378E8 3.35E7 0.88 1.85902653E8 2.65E7 0.75 1.1486 0.9968 3067966 PK04_095122 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCN3CCOCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G03 mock treatment 1.81523775E8 2.83E7 0.74 1.87288368E8 2.79E7 0.79 1.0795 0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G04 mock treatment 1.70034329E8 1.68E7 0.44 1.73586945E8 1.42E7 0.4 0.5938 0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G05 compound treatment 1.44520268E8 -8740000.0 -0.23 1.56806326E8 -2570000.0 -0.07 -0.2129 -0.8876 3068153 PK04_095123 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G06 compound treatment 1.6350736E8 1.03E7 0.27 1.64356948E8 4980000.0 0.14 0.289 0.9543 3187356 PK04_095124 COCCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G07 compound treatment 1.54970023E8 1710000.0 0.04 1.57834775E8 -1540000.0 -0.04 0.001 0.0166 3187173 PK04_095125 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G08 compound treatment 1.59270946E8 6020000.0 0.16 1.61675419E8 2300000.0 0.06 0.1572 0.923 3068514 PK04_095126 CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G09 compound treatment 1.45095971E8 -8160000.0 -0.21 1.43459244E8 -1.59E7 -0.45 -0.4682 -0.9424 3187442 PK04_095127 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G10 compound treatment 1.50744103E8 -2510000.0 -0.07 1.6090435E8 1530000.0 0.04 -0.016 -0.2038 3068420 PK04_095128 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G11 compound treatment 1.47710249E8 -5550000.0 -0.15 1.57851697E8 -1520000.0 -0.04 -0.133 -0.8786 3187434 PK04_095129 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G12 compound treatment 1.09471164E8 -4.38E7 -1.15 1.13103005E8 -4.63E7 -1.3 -1.7325 -0.9979 3186416 PK04_095130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G13 compound treatment 1.53226216E8 -29300.0 0.0 1.62318447E8 2940000.0 0.08 0.0581 0.7005 3068507 PK04_095131 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G14 compound treatment 1.48859303E8 -4400000.0 -0.12 1.53117036E8 -6260000.0 -0.18 -0.2061 -0.9786 3187162 PK04_095132 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G15 compound treatment 1.4661867E8 -6640000.0 -0.17 1.53355541E8 -6020000.0 -0.17 -0.2428 -0.9999 3068602 PK04_095133 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G16 compound treatment 1.37570634E8 -1.57E7 -0.41 1.36317547E8 -2.31E7 -0.65 -0.7498 -0.9755 3187426 PK04_095134 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G17 compound treatment 1.29379324E8 -2.39E7 -0.63 1.33713906E8 -2.57E7 -0.72 -0.9533 -0.9974 3067567 PK04_095135 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G18 compound treatment 8.5254382E7 -6.8E7 -1.78 9.0143348E7 -6.92E7 -1.95 -2.6382 -0.999 3187525 PK04_095136 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G19 mock treatment 1.6010968E8 6850000.0 0.18 1.61961546E8 2590000.0 0.07 0.1784 0.9212 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G20 mock treatment 1.61000097E8 7740000.0 0.2 1.6648117E8 7110000.0 0.2 0.2849 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G21 compound treatment 1.65459848E8 1.22E7 0.32 1.74024451E8 1.46E7 0.41 0.5178 0.992 3187167 PK04_095137 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G22 compound treatment 1.68863071E8 1.56E7 0.41 1.79603572E8 2.02E7 0.57 0.692 0.9867 3187174 PK04_095138 COc1ccccc1CN2[C@H]([C@H](C(=O)NC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G23 compound treatment 1.75742949E8 2.25E7 0.59 1.77183453E8 1.78E7 0.5 0.7711 0.9968 3068478 PK04_095139 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 G24 compound treatment 1.91985994E8 3.87E7 1.01 1.97502116E8 3.81E7 1.07 1.4766 0.9996 3068471 PK04_095140 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H01 compound treatment 1.7512017E8 2.19E7 0.57 1.67977876E8 8600000.0 0.24 0.5761 0.9269 3068149 PK04_095141 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H02 compound treatment 1.24096955E8 -2.92E7 -0.76 1.3178196E8 -2.76E7 -0.78 -1.0896 -1.0 3068236 PK04_095142 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H03 mock treatment 1.78775711E8 2.55E7 0.67 1.81059851E8 2.17E7 0.61 0.9045 0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H04 mock treatment 1.65252534E8 1.2E7 0.31 1.66625407E8 7250000.0 0.2 0.3665 0.9783 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H05 compound treatment 1.58494394E8 5240000.0 0.14 1.60671406E8 1300000.0 0.04 0.1228 0.8653 3187083 PK04_095143 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H06 compound treatment 8.6463746E7 -6.68E7 -1.75 8.6027833E7 -7.33E7 -2.07 -2.6979 -0.9965 3068265 PK04_095144 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H07 compound treatment 1.54282441E8 1030000.0 0.03 1.55588323E8 -3790000.0 -0.11 -0.0565 -0.513 3068458 PK04_095145 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H08 compound treatment 1.53353013E8 97500.0 0.0 1.558538E8 -3520000.0 -0.1 -0.0684 -0.6887 3068401 PK04_095146 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H09 compound treatment 1.54327374E8 1070000.0 0.03 1.57561925E8 -1810000.0 -0.05 -0.0163 -0.2795 3187071 PK04_095147 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H10 compound treatment 1.39051389E8 -1.42E7 -0.37 1.43677083E8 -1.57E7 -0.44 -0.5757 -0.9963 3068139 PK04_095148 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H11 compound treatment 1.41759669E8 -1.15E7 -0.3 1.53321664E8 -6050000.0 -0.17 -0.3334 -0.9639 3187589 PK04_095149 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H12 compound treatment 1.41220316E8 -1.2E7 -0.32 1.47122848E8 -1.23E7 -0.35 -0.4669 -0.999 3186627 PK04_095150 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H13 compound treatment 1.47215549E8 -6040000.0 -0.16 1.52189511E8 -7190000.0 -0.2 -0.255 -0.9925 3187261 PK04_095151 CC(C)N1[C@H]([C@H](C(=O)NC2CC2)c3ccccc3C1=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H14 compound treatment 1.48331609E8 -4920000.0 -0.13 1.54114107E8 -5260000.0 -0.15 -0.196 -0.9976 3186980 PK04_095152 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H15 compound treatment 1.52335386E8 -920000.0 -0.02 1.60038744E8 663000.0 0.02 -0.0038 -0.125 3187166 PK04_095153 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H16 compound treatment 1.43569162E8 -9690000.0 -0.25 1.52068439E8 -7310000.0 -0.21 -0.3249 -0.9947 3186978 PK04_095154 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H17 compound treatment 1.5361579E8 360000.0 0.01 1.61398789E8 2020000.0 0.06 0.047 0.813 3187349 PK04_095155 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCCN(C)C)c3ccccc3C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H18 compound treatment 1.5543903E8 2180000.0 0.06 1.58583691E8 -792000.0 -0.02 0.0246 0.4016 3068412 PK04_095156 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H19 mock treatment 1.53794907E8 539000.0 0.01 1.62351087E8 2980000.0 0.08 0.0693 0.8147 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H20 mock treatment 1.53536132E8 281000.0 0.01 1.60928045E8 1550000.0 0.04 0.0361 0.8144 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H21 compound treatment 1.59396116E8 6140000.0 0.16 1.6650128E8 7130000.0 0.2 0.2557 0.9939 3187512 PK04_095157 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H22 compound treatment 9.8067646E7 -5.52E7 -1.44 9.3116347E7 -6.63E7 -1.87 -2.3418 -0.992 3186806 PK04_095158 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H23 compound treatment 1.70013054E8 1.68E7 0.44 1.82028252E8 2.27E7 0.64 0.7616 0.9832 3068599 PK04_095159 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NC4CC4)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 H24 compound treatment 1.78831067E8 2.56E7 0.67 1.98711376E8 3.93E7 1.11 1.2572 0.9708 3187586 PK04_095160 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I01 compound treatment 1.94255754E8 4.1E7 1.07 1.9413214E8 3.48E7 0.98 1.4515 0.999 3187165 PK04_095161 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I02 compound treatment 1.72754623E8 1.95E7 0.51 1.86862385E8 2.75E7 0.77 0.9086 0.9795 3068418 PK04_095162 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I03 compound treatment 1.6345004E8 1.02E7 0.27 1.80297775E8 2.09E7 0.59 0.6056 0.9358 3187178 PK04_095163 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I04 compound treatment 1.69598631E8 1.63E7 0.43 1.77060692E8 1.77E7 0.5 0.6549 0.9971 3068019 PK04_095164 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I05 mock treatment 1.59476498E8 6220000.0 0.16 1.61748134E8 2370000.0 0.07 0.1624 0.9227 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I06 mock treatment 1.58338697E8 5080000.0 0.13 1.54919751E8 -4460000.0 -0.13 0.0053 0.029 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I07 compound treatment 1.48582007E8 -4670000.0 -0.12 1.52931229E8 -6440000.0 -0.18 -0.2149 -0.9815 3068542 PK04_095165 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3Cc4ccccc4C3)C(=O)c5ccccc25)c6ccc(CO)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I08 compound treatment 1.53363671E8 108000.0 0.0 1.52702534E8 -6670000.0 -0.19 -0.131 -0.6964 3187345 PK04_095166 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I09 compound treatment 7.784186E7 -7.54E7 -1.97 8.0270825E7 -7.91E7 -2.23 -2.9722 -0.9982 3067971 PK04_095167 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I10 compound treatment 1.46537607E8 -6720000.0 -0.18 1.4805576E8 -1.13E7 -0.32 -0.3499 -0.9606 3068641 PK04_095168 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I11 compound treatment 1.44191879E8 -9060000.0 -0.24 1.50528662E8 -8850000.0 -0.25 -0.344 -0.9997 3187358 PK04_095169 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I12 compound treatment 1.34854107E8 -1.84E7 -0.48 1.43041248E8 -1.63E7 -0.46 -0.6661 -0.9997 3068653 PK04_095170 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I13 compound treatment 1.34379169E8 -1.89E7 -0.49 1.44382058E8 -1.5E7 -0.42 -0.6482 -0.997 3067962 PK04_095171 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I14 compound treatment 1.30816397E8 -2.24E7 -0.59 1.46552391E8 -1.28E7 -0.36 -0.6709 -0.9728 3068606 PK04_095172 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I15 compound treatment 1.42694566E8 -1.06E7 -0.28 1.54453086E8 -4920000.0 -0.14 -0.2936 -0.9491 3068476 PK04_095173 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I16 compound treatment 1.1698234E8 -3.63E7 -0.95 1.23844744E8 -3.55E7 -1.0 -1.3794 -0.9996 3186417 PK04_095174 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I17 compound treatment 1.44268637E8 -8990000.0 -0.24 1.5271787E8 -6660000.0 -0.19 -0.299 -0.9937 3187268 PK04_095175 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I18 compound treatment 1.47210385E8 -6050000.0 -0.16 1.54063487E8 -5310000.0 -0.15 -0.2177 -0.9996 3187264 PK04_095176 CC(C)N1[C@H]([C@H](C(=O)NCC(F)(F)F)c2ccccc2C1=O)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I19 compound treatment 9.8991829E7 -5.43E7 -1.42 1.11149199E8 -4.82E7 -1.36 -1.9654 -0.9998 3186499 PK04_095177 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I20 compound treatment 1.51257695E8 -2000000.0 -0.05 1.6108095E8 1710000.0 0.05 -0.003 -0.0421 3068422 PK04_095178 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I21 mock treatment 1.58855346E8 5600000.0 0.15 1.68296411E8 8920000.0 0.25 0.2814 0.967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I22 mock treatment 1.63318004E8 1.01E7 0.26 1.71757483E8 1.24E7 0.35 0.433 0.9904 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I23 compound treatment 1.71877031E8 1.86E7 0.49 1.81122358E8 2.17E7 0.61 0.778 0.9936 3068550 PK04_095179 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(C)C)C(=O)c3ccccc23)c4ccc(CO)cc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 I24 compound treatment 2.01647299E8 4.84E7 1.27 2.02888824E8 4.35E7 1.23 1.7628 0.9999 3187258 PK04_095180 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4Cc5ccccc5C4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J01 compound treatment 1.99012685E8 4.58E7 1.2 1.92778764E8 3.34E7 0.94 1.5126 0.9929 3187273 PK04_095181 CC(C)CNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J02 compound treatment 1.63522642E8 1.03E7 0.27 1.84935199E8 2.56E7 0.72 0.6994 0.9097 3186630 PK04_095182 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J03 compound treatment 1.18786518E8 -3.45E7 -0.9 1.34711304E8 -2.47E7 -0.7 -1.1295 -0.9917 3187353 PK04_095183 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(=O)c3ccccc32)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J04 compound treatment 1.56325568E8 3070000.0 0.08 1.65771403E8 6400000.0 0.18 0.1843 0.9338 3187588 PK04_095184 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)O)c3ccccc3C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J05 mock treatment 1.54079415E8 824000.0 0.02 1.62461697E8 3090000.0 0.09 0.0768 0.8565 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J06 mock treatment 1.4677565E8 -6480000.0 -0.17 1.50232004E8 -9140000.0 -0.26 -0.3021 -0.9794 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J07 compound treatment 1.09507766E8 -4.37E7 -1.15 1.15971874E8 -4.34E7 -1.22 -1.6746 -0.9995 3186420 PK04_095185 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J08 compound treatment 8.3177355E7 -7.01E7 -1.83 8.1333744E7 -7.8E7 -2.2 -2.8522 -0.9959 3186722 PK04_095186 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J09 compound treatment 7.1700417E7 -8.16E7 -2.13 7.2298862E7 -8.71E7 -2.45 -3.2447 -0.9976 3186426 PK04_095187 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J10 compound treatment 1.36213837E8 -1.7E7 -0.45 1.3655767E8 -2.28E7 -0.64 -0.7701 -0.984 3186639 PK04_095188 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J11 compound treatment 1.37245493E8 -1.6E7 -0.42 1.41406453E8 -1.8E7 -0.51 -0.6544 -0.9956 3187270 PK04_095189 CC(C)NC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J12 compound treatment 1.35037438E8 -1.82E7 -0.48 1.43115193E8 -1.63E7 -0.46 -0.6612 -0.9998 3067980 PK04_095190 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J13 compound treatment 2.7848958E7 -1.25E8 -3.28 2.8654181E7 -1.31E8 -3.68 -4.9261 -0.9983 3186421 PK04_095191 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J14 compound treatment 1.07691554E8 -4.56E7 -1.19 1.14141098E8 -4.52E7 -1.27 -1.7447 -0.9994 3068150 PK04_095192 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J15 compound treatment 1.38231097E8 -1.5E7 -0.39 1.45882471E8 -1.35E7 -0.38 -0.547 -0.9999 3068598 PK04_095193 CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J16 compound treatment 7.6145887E7 -7.71E7 -2.02 8.1060152E7 -7.83E7 -2.21 -2.9878 -0.999 3068324 PK04_095194 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J17 compound treatment 7.7369236E7 -7.59E7 -1.99 7.8273246E7 -8.11E7 -2.29 -3.0207 -0.9976 3067973 PK04_095195 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J18 compound treatment 1.43332958E8 -9920000.0 -0.26 1.47973397E8 -1.14E7 -0.32 -0.4109 -0.9944 3068414 PK04_095196 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J19 compound treatment 1.42695775E8 -1.06E7 -0.28 1.55752887E8 -3620000.0 -0.1 -0.2676 -0.9083 3187085 PK04_095197 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J20 compound treatment 1.52501568E8 -754000.0 -0.02 1.64216519E8 4840000.0 0.14 0.0825 0.5986 3186884 PK04_095198 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J21 mock treatment 1.53350842E8 95400.0 0.0 1.63204822E8 3830000.0 0.11 0.0781 0.7233 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J22 mock treatment 1.57118971E8 3860000.0 0.1 1.7034626E8 1.1E7 0.31 0.2901 0.8919 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J23 compound treatment 1.79591543E8 2.63E7 0.69 1.87660454E8 2.83E7 0.8 1.0511 0.9974 3187082 PK04_095199 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 J24 compound treatment 1.84284843E8 3.1E7 0.81 1.92748062E8 3.34E7 0.94 1.2394 0.9973 3068227 PK04_095200 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K01 compound treatment 1.0322856E8 -5.0E7 -1.31 1.04974949E8 -5.44E7 -1.53 -2.01 -0.9969 3187514 PK04_095201 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K02 compound treatment 1.6929218E8 1.6E7 0.42 1.81248576E8 2.19E7 0.62 0.7327 0.9825 3187168 PK04_095202 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccc(OC(F)(F)F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K03 compound treatment 1.12078344E8 -4.12E7 -1.08 1.1464266E8 -4.47E7 -1.26 -1.6535 -0.997 3068143 PK04_095203 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC5CC5)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K04 compound treatment 1.32281945E8 -2.1E7 -0.55 1.43117688E8 -1.63E7 -0.46 -0.7122 -0.996 3187275 PK04_095204 CN(C)CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K05 compound treatment 1.46516454E8 -6740000.0 -0.18 1.47845806E8 -1.15E7 -0.32 -0.3545 -0.9588 3187271 PK04_095205 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K06 compound treatment 3.6887824E7 -1.16E8 -3.05 3.3461881E7 -1.26E8 -3.55 -4.663 -0.9971 3186561 PK04_095206 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K07 mock treatment 1.40285142E8 -1.3E7 -0.34 1.40835075E8 -1.85E7 -0.52 -0.6095 -0.9782 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K08 mock treatment 1.45336162E8 -7920000.0 -0.21 1.44561125E8 -1.48E7 -0.42 -0.4418 -0.9478 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K09 compound treatment 1.43199604E8 -1.01E7 -0.26 1.41542329E8 -1.78E7 -0.5 -0.5415 -0.9545 3068519 PK04_095207 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K10 compound treatment 1.40586739E8 -1.27E7 -0.33 1.45346766E8 -1.4E7 -0.4 -0.514 -0.9962 3068466 PK04_095208 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K11 compound treatment 1.31103632E8 -2.22E7 -0.58 1.35259765E8 -2.41E7 -0.68 -0.8906 -0.9969 3068556 PK04_095209 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K12 compound treatment 6.5877391E7 -8.74E7 -2.29 6.8974025E7 -9.04E7 -2.55 -3.4187 -0.9986 3067978 PK04_095210 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K13 compound treatment 1.34997546E8 -1.83E7 -0.48 1.39758739E8 -1.96E7 -0.55 -0.7288 -0.9974 3068499 PK04_095211 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K14 compound treatment 1.28171318E8 -2.51E7 -0.66 1.40982967E8 -1.84E7 -0.52 -0.8308 -0.9931 3068588 PK04_095212 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K15 mock treatment 1.40502107E8 -1.28E7 -0.33 1.43543892E8 -1.58E7 -0.45 -0.5515 -0.9898 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K16 mock treatment 1.36426016E8 -1.68E7 -0.44 1.4264272E8 -1.67E7 -0.47 -0.6449 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K17 compound treatment 7.8129628E7 -7.51E7 -1.97 8.2934577E7 -7.64E7 -2.15 -2.9138 -0.999 3068009 PK04_095213 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K18 compound treatment 3.0940294E7 -1.22E8 -3.2 3.1414068E7 -1.28E8 -3.61 -4.8139 -0.9982 3186498 PK04_095214 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCCN(C)C)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K19 compound treatment 1.47938329E8 -5320000.0 -0.14 1.55501921E8 -3870000.0 -0.11 -0.1756 -0.9928 3068472 PK04_095215 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K20 compound treatment 1.5465802E8 1400000.0 0.04 1.63979636E8 4600000.0 0.13 0.1177 0.8729 3187259 PK04_095216 COCCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K21 compound treatment 1.57771925E8 4520000.0 0.12 1.67882131E8 8510000.0 0.24 0.2531 0.9469 3187078 PK04_095217 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K22 compound treatment 1.53674793E8 419000.0 0.01 1.64692171E8 5320000.0 0.15 0.1137 0.7569 3068508 PK04_095218 COc1ccccc1CN2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K23 mock treatment 1.61313134E8 8060000.0 0.21 1.69961526E8 1.06E7 0.3 0.3601 0.9856 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 K24 mock treatment 1.84506496E8 3.13E7 0.82 1.9635436E8 3.7E7 1.04 1.3153 0.9928 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L01 compound treatment 1.75717144E8 2.25E7 0.59 1.88716262E8 2.93E7 0.83 1.0004 0.986 3187175 PK04_095219 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCCN(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L02 compound treatment 8.7678386E7 -6.56E7 -1.72 8.9267134E7 -7.01E7 -1.98 -2.6108 -0.9975 3186714 PK04_095220 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L03 compound treatment 1.64770664E8 1.15E7 0.3 1.69204013E8 9830000.0 0.28 0.409 0.9991 3067967 PK04_095221 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCc3ccccc3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L04 compound treatment 1.39326092E8 -1.39E7 -0.36 1.51508205E8 -7870000.0 -0.22 -0.4146 -0.9716 3186429 PK04_095222 CC(C)CN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L05 compound treatment 1.57071557E8 3820000.0 0.1 1.65002284E8 5630000.0 0.16 0.1828 0.9752 3068540 PK04_095223 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L06 compound treatment 1.46207464E8 -7050000.0 -0.18 1.50093073E8 -9280000.0 -0.26 -0.3154 -0.9854 3186551 PK04_095224 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L07 mock treatment 1.39245147E8 -1.4E7 -0.37 1.51251812E8 -8120000.0 -0.23 -0.4212 -0.9743 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L08 mock treatment 1.43316739E8 -9940000.0 -0.26 1.43524039E8 -1.59E7 -0.45 -0.4998 -0.9669 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L09 compound treatment 3.6245774E7 -1.17E8 -3.06 3.3636596E7 -1.26E8 -3.54 -4.6714 -0.9974 3187518 PK04_095225 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L10 compound treatment 1.38147135E8 -1.51E7 -0.4 1.35220132E8 -2.42E7 -0.68 -0.761 -0.9666 3068144 PK04_095226 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCc5ccccc5)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L11 compound treatment 1.2171316E8 -3.15E7 -0.83 1.29452113E8 -2.99E7 -0.84 -1.1801 -0.9999 3187076 PK04_095227 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L12 compound treatment 7.1865479E7 -8.14E7 -2.13 7.3911627E7 -8.55E7 -2.41 -3.2095 -0.9981 3068313 PK04_095228 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L13 compound treatment 8.7685883E7 -6.56E7 -1.72 1.08930943E8 -5.04E7 -1.42 -2.2189 -0.9956 3187347 PK04_095229 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(C)C)C(=O)c3ccccc32)c4ccc(CO)cc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L14 compound treatment 1.3495204E8 -1.83E7 -0.48 1.40169696E8 -1.92E7 -0.54 -0.7215 -0.9982 3068194 PK04_095230 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(C)C)C4=O)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L15 mock treatment 1.26202107E8 -2.71E7 -0.71 1.36918698E8 -2.25E7 -0.63 -0.9482 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L16 mock treatment 1.25333268E8 -2.79E7 -0.73 1.38641573E8 -2.07E7 -0.58 -0.93 -0.9938 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L17 compound treatment 1.40352289E8 -1.29E7 -0.34 1.45292267E8 -1.41E7 -0.4 -0.5195 -0.9968 3068510 PK04_095231 COc1ccccc1CN2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L18 compound treatment 7.7979268E7 -7.53E7 -1.97 8.6960092E7 -7.24E7 -2.04 -2.8363 -0.9998 3068263 PK04_095232 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3I)Sc4ccc(C)cc4)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L19 compound treatment 1.5101976E8 -2240000.0 -0.06 1.54025708E8 -5350000.0 -0.15 -0.148 -0.9151 3067958 PK04_095233 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L20 compound treatment 1.55080369E8 1820000.0 0.05 1.6020263E8 827000.0 0.02 0.0503 0.9456 3068403 PK04_095234 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L21 compound treatment 1.45588537E8 -7670000.0 -0.2 1.62432406E8 3060000.0 0.09 -0.081 -0.3709 3187163 PK04_095235 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L22 compound treatment 1.43541872E8 -9710000.0 -0.25 1.63612733E8 4240000.0 0.12 -0.0954 -0.3395 3186433 PK04_095236 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L23 mock treatment 1.66540339E8 1.33E7 0.35 1.71367945E8 1.2E7 0.34 0.4849 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 L24 mock treatment 1.87959222E8 3.47E7 0.91 1.98975128E8 3.96E7 1.12 1.4314 0.9948 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M01 compound treatment 1.9539018E8 4.21E7 1.1 1.99938256E8 4.06E7 1.14 1.5882 0.9998 3187444 PK04_095237 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M02 compound treatment 1.62793173E8 9540000.0 0.25 1.65827743E8 6450000.0 0.18 0.3051 0.9879 3068593 PK04_095238 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NC3CC3)c4ccccc4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M03 compound treatment 1.57763099E8 4510000.0 0.12 1.61052039E8 1680000.0 0.05 0.1168 0.9193 3187441 PK04_095239 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M04 compound treatment 1.51102636E8 -2150000.0 -0.06 1.59379432E8 4090.0 0.0 -0.0398 -0.7057 3068649 PK04_095240 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M05 compound treatment 2.804839E7 -1.25E8 -3.28 2.9675537E7 -1.3E8 -3.65 -4.902 -0.9985 3068152 PK04_095241 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M06 compound treatment 1.34088039E8 -1.92E7 -0.5 1.4478096E8 -1.46E7 -0.41 -0.6456 -0.9951 3068655 PK04_095242 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M07 compound treatment 1.35372195E8 -1.79E7 -0.47 1.45623062E8 -1.38E7 -0.39 -0.6051 -0.9956 3068005 PK04_095243 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M08 compound treatment 1.42862258E8 -1.04E7 -0.27 1.44770322E8 -1.46E7 -0.41 -0.4834 -0.9798 3187084 PK04_095244 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M09 mock treatment 1.44077623E8 -9180000.0 -0.24 1.36688683E8 -2.27E7 -0.64 -0.6219 -0.9107 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M10 mock treatment 1.25624347E8 -2.76E7 -0.72 1.34424193E8 -2.5E7 -0.7 -1.0086 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M11 compound treatment 5.6172228E7 -9.71E7 -2.54 5.4558004E7 -1.05E8 -2.95 -3.8856 -0.9972 3186422 PK04_095245 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M12 compound treatment 2.7854976E7 -1.25E8 -3.28 2.9844499E7 -1.3E8 -3.65 -4.9022 -0.9986 3068142 PK04_095246 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M13 mock treatment 1.23215811E8 -3.0E7 -0.79 1.30744882E8 -2.86E7 -0.81 -1.1265 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M14 mock treatment 1.23536472E8 -2.97E7 -0.78 1.35698897E8 -2.37E7 -0.67 -1.0219 -0.9971 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M15 compound treatment 1.20006762E8 -3.32E7 -0.87 1.42452639E8 -1.69E7 -0.48 -0.9526 -0.9599 3068557 PK04_095247 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5CCCCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M16 compound treatment 1.19343875E8 -3.39E7 -0.89 1.38179076E8 -2.12E7 -0.6 -1.0501 -0.9814 3187170 PK04_095248 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M17 compound treatment 1.25089108E8 -2.82E7 -0.74 1.48373927E8 -1.1E7 -0.31 -0.7406 -0.9259 3187431 PK04_095249 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M18 compound treatment 1.34458199E8 -1.88E7 -0.49 1.48554756E8 -1.08E7 -0.3 -0.5636 -0.9735 3187074 PK04_095250 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M19 compound treatment 1.43064083E8 -1.02E7 -0.27 1.57415901E8 -1960000.0 -0.06 -0.2277 -0.8357 3068552 PK04_095251 CC(C)NC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M20 compound treatment 1.2836272E8 -2.49E7 -0.65 1.49910612E8 -9460000.0 -0.27 -0.6494 -0.9223 3068014 PK04_095252 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)O)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M21 compound treatment 1.58969188E8 5710000.0 0.15 1.64858983E8 5480000.0 0.15 0.215 0.9999 3187086 PK04_095253 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M22 compound treatment 1.43268159E8 -9990000.0 -0.26 1.62187928E8 2810000.0 0.08 -0.1288 -0.4715 3187428 PK04_095254 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M23 compound treatment 1.62499862E8 9240000.0 0.24 1.71209343E8 1.18E7 0.33 0.4069 0.9876 3187081 PK04_095255 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 M24 compound treatment 1.82151082E8 2.89E7 0.76 1.91513906E8 3.21E7 0.91 1.1753 0.996 3068003 PK04_095256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N01 compound treatment 1.74959188E8 2.17E7 0.57 1.85582174E8 2.62E7 0.74 0.9239 0.9916 3187360 PK04_095257 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N02 compound treatment 1.82115304E8 2.89E7 0.76 1.82932592E8 2.36E7 0.66 1.0036 0.9979 3068231 PK04_095258 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N03 compound treatment 1.63258077E8 1.0E7 0.26 1.68155403E8 8780000.0 0.25 0.3601 0.9996 3068544 PK04_095259 CC(C)NC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N04 compound treatment 1.26935609E8 -2.63E7 -0.69 1.40613768E8 -1.88E7 -0.53 -0.861 -0.9915 3187527 PK04_095260 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N05 compound treatment 1.41766621E8 -1.15E7 -0.3 1.48010391E8 -1.14E7 -0.32 -0.4391 -0.9995 3187260 PK04_095261 CCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N06 compound treatment 8.2186786E7 -7.11E7 -1.86 8.0026615E7 -7.93E7 -2.24 -2.8966 -0.9958 3186724 PK04_095262 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N07 compound treatment 1.35658334E8 -1.76E7 -0.46 1.47204647E8 -1.22E7 -0.34 -0.5682 -0.9895 3068501 PK04_095263 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N08 compound treatment 1.35826251E8 -1.74E7 -0.46 1.40553895E8 -1.88E7 -0.53 -0.6977 -0.9972 3186871 PK04_095264 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N09 mock treatment 1.33164722E8 -2.01E7 -0.53 1.29336534E8 -3.0E7 -0.85 -0.9704 -0.9738 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N10 mock treatment 1.29583074E8 -2.37E7 -0.62 1.26557123E8 -3.28E7 -0.92 -1.0921 -0.981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N11 compound treatment 1.30759218E8 -2.25E7 -0.59 1.24906263E8 -3.45E7 -0.97 -1.1033 -0.9712 3187070 PK04_095265 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N12 compound treatment 7.6406588E7 -7.68E7 -2.01 7.5212412E7 -8.42E7 -2.37 -3.0995 -0.9966 3186804 PK04_095266 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N13 mock treatment 1.12655815E8 -4.06E7 -1.06 1.22401081E8 -3.7E7 -1.04 -1.4883 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N14 mock treatment 1.27100791E8 -2.62E7 -0.68 1.27808056E8 -3.16E7 -0.89 -1.1131 -0.9916 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N15 compound treatment 2.7971037E7 -1.25E8 -3.28 2.9454218E7 -1.3E8 -3.66 -4.9079 -0.9985 3186424 PK04_095267 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N16 compound treatment 1.30140214E8 -2.31E7 -0.61 1.35756123E8 -2.36E7 -0.67 -0.8985 -0.9989 3068226 PK04_095268 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N17 compound treatment 1.34626857E8 -1.86E7 -0.49 1.44459066E8 -1.49E7 -0.42 -0.642 -0.9973 3068455 PK04_095269 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N18 compound treatment 1.26435988E8 -2.68E7 -0.7 1.42622297E8 -1.68E7 -0.47 -0.8303 -0.9814 3068137 PK04_095270 CN(C)CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N19 compound treatment 1.26306581E8 -2.69E7 -0.71 1.51055939E8 -8320000.0 -0.23 -0.6646 -0.894 3068647 PK04_095271 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N20 compound treatment 1.33502599E8 -1.98E7 -0.52 1.42307216E8 -1.71E7 -0.48 -0.7057 -0.9993 3186492 PK04_095272 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N21 compound treatment 1.29766205E8 -2.35E7 -0.61 1.46427479E8 -1.29E7 -0.36 -0.6928 -0.969 3067959 PK04_095273 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N22 compound treatment 1.4806165E8 -5190000.0 -0.14 1.61398377E8 2020000.0 0.06 -0.0558 -0.3787 3187526 PK04_095274 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)O)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N23 compound treatment 1.58915286E8 5660000.0 0.15 1.70056485E8 1.07E7 0.3 0.3176 0.9467 3068468 PK04_095275 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 N24 compound treatment 1.84504837E8 3.12E7 0.82 1.9545544E8 3.61E7 1.02 1.2974 0.9942 3068222 PK04_095276 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O01 compound treatment 1.88363452E8 3.51E7 0.92 1.94001726E8 3.46E7 0.98 1.3398 0.9996 3068590 PK04_095277 CC(C)NC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O02 compound treatment 8.9395652E7 -6.39E7 -1.67 1.01012643E8 -5.84E7 -1.64 -2.345 -1.0 3067977 PK04_095278 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O03 compound treatment 1.6733247E8 1.41E7 0.37 1.70409908E8 1.1E7 0.31 0.4804 0.9964 3068512 PK04_095279 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O04 compound treatment 1.50805991E8 -2450000.0 -0.06 1.58233968E8 -1140000.0 -0.03 -0.0681 -0.9491 3068637 PK04_095280 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O05 compound treatment 1.49486606E8 -3770000.0 -0.1 1.50519372E8 -8860000.0 -0.25 -0.2462 -0.9175 3068459 PK04_095281 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O06 compound treatment 1.40903459E8 -1.24E7 -0.32 1.43141242E8 -1.62E7 -0.46 -0.5521 -0.9856 3187520 PK04_095282 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O07 compound treatment 1.30910852E8 -2.23E7 -0.58 1.38135532E8 -2.12E7 -0.6 -0.8368 -0.9999 3186989 PK04_095283 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O08 compound treatment 1.3159771E8 -2.17E7 -0.57 1.33309748E8 -2.61E7 -0.73 -0.9203 -0.9918 3187364 PK04_095284 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O09 compound treatment 1.32457764E8 -2.08E7 -0.54 1.33952779E8 -2.54E7 -0.72 -0.8915 -0.9908 3068604 PK04_095285 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O10 compound treatment 1.29957728E8 -2.33E7 -0.61 1.26316053E8 -3.31E7 -0.93 -1.09 -0.9789 3187362 PK04_095286 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O11 mock treatment 1.23389011E8 -2.99E7 -0.78 1.18426648E8 -4.09E7 -1.15 -1.3688 -0.982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O12 mock treatment 1.24149276E8 -2.91E7 -0.76 1.27485342E8 -3.19E7 -0.9 -1.1742 -0.9966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O13 compound treatment 1.18534643E8 -3.47E7 -0.91 1.17997828E8 -4.14E7 -1.17 -1.4672 -0.9924 3068644 PK04_095287 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O14 compound treatment 1.21337157E8 -3.19E7 -0.84 1.33444055E8 -2.59E7 -0.73 -1.1075 -0.9978 3068464 PK04_095288 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O15 compound treatment 5.517508E7 -9.81E7 -2.57 5.9699763E7 -9.97E7 -2.81 -3.8016 -0.999 3187516 PK04_095289 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O16 compound treatment 1.37774418E8 -1.55E7 -0.41 1.385272E8 -2.08E7 -0.59 -0.702 -0.9836 3187164 PK04_095290 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O17 compound treatment 1.44303864E8 -8950000.0 -0.23 1.48948059E8 -1.04E7 -0.29 -0.3735 -0.9937 3187177 PK04_095291 CC(C)CNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O18 compound treatment 1.34266055E8 -1.9E7 -0.5 1.42363695E8 -1.7E7 -0.48 -0.6905 -0.9998 3068546 PK04_095292 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O19 compound treatment 1.41600312E8 -1.17E7 -0.31 1.51914923E8 -7460000.0 -0.21 -0.3644 -0.9835 3187256 PK04_095293 CC(C)CNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O20 compound treatment 1.42626368E8 -1.06E7 -0.28 1.5093822E8 -8440000.0 -0.24 -0.3649 -0.9969 3187088 PK04_095294 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O21 compound treatment 1.5077672E8 -2480000.0 -0.06 1.56381665E8 -2990000.0 -0.08 -0.1055 -0.9916 3186494 PK04_095295 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(C)C)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O22 compound treatment 1.6040749E8 7150000.0 0.19 1.67971934E8 8600000.0 0.24 0.3037 0.9919 3187161 PK04_095296 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O23 compound treatment 1.67773218E8 1.45E7 0.38 1.7583688E8 1.65E7 0.46 0.5967 0.9951 3187267 PK04_095297 CC(C)CNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 O24 compound treatment 1.88624075E8 3.54E7 0.93 2.01527708E8 4.22E7 1.19 1.4946 0.9924 3068502 PK04_095298 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P01 compound treatment 2.07470771E8 5.42E7 1.42 2.09122305E8 4.97E7 1.4 1.9948 1.0 3068591 PK04_095299 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2CC4(CC5CC6CC(C5)C4)C6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P02 compound treatment 1.83600599E8 3.03E7 0.79 1.86377484E8 2.7E7 0.76 1.0997 0.9998 3187521 PK04_095300 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P03 compound treatment 1.32383115E8 -2.09E7 -0.55 1.39729408E8 -1.96E7 -0.55 -0.7778 -1.0 3186990 PK04_095301 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P04 compound treatment 1.67058028E8 1.38E7 0.36 1.717755E8 1.24E7 0.35 0.5026 0.9999 3186985 PK04_095302 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P05 compound treatment 4.9732173E7 -1.04E8 -2.71 5.6375434E7 -1.03E8 -2.9 -3.9686 -0.9994 3067579 PK04_095303 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P06 compound treatment 1.52822437E8 -433000.0 -0.01 1.55475686E8 -3900000.0 -0.11 -0.0857 -0.7759 3186975 PK04_095304 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P07 compound treatment 1.46982904E8 -6270000.0 -0.16 1.45017612E8 -1.44E7 -0.4 -0.4022 -0.9211 3068548 PK04_095305 CC(C)CNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P08 compound treatment 1.48372139E8 -4880000.0 -0.13 1.49313046E8 -1.01E7 -0.28 -0.2909 -0.9352 3067563 PK04_095306 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CCN5CCOCC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P09 compound treatment 1.33563715E8 -1.97E7 -0.52 1.3261688E8 -2.68E7 -0.75 -0.8977 -0.9828 3067961 PK04_095307 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P10 compound treatment 1.36947214E8 -1.63E7 -0.43 1.37738124E8 -2.16E7 -0.61 -0.733 -0.9848 3068015 PK04_095308 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P11 mock treatment 1.32252291E8 -2.1E7 -0.55 1.25533397E8 -3.38E7 -0.95 -1.0631 -0.9658 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P12 mock treatment 1.3441885E8 -1.88E7 -0.49 1.26450429E8 -3.29E7 -0.93 -1.0047 -0.9562 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P13 compound treatment 1.29668185E8 -2.36E7 -0.62 1.30426534E8 -2.89E7 -0.82 -1.0134 -0.9906 3187510 PK04_095309 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P14 compound treatment 5.5916183E7 -9.73E7 -2.55 6.2469484E7 -9.69E7 -2.73 -3.7327 -0.9994 3186495 PK04_095310 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCN5CCOCC5)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P15 compound treatment 1.36011047E8 -1.72E7 -0.45 1.35919498E8 -2.35E7 -0.66 -0.7866 -0.9827 3187437 PK04_095311 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P16 compound treatment 1.34012139E8 -1.92E7 -0.5 1.48796908E8 -1.06E7 -0.3 -0.567 -0.9687 3186625 PK04_095312 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C(C)C)C4=O)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P17 compound treatment 1.30038224E8 -2.32E7 -0.61 1.51786914E8 -7590000.0 -0.21 -0.581 -0.9017 3068541 PK04_095313 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P18 compound treatment 1.35510462E8 -1.77E7 -0.46 1.48123724E8 -1.13E7 -0.32 -0.5527 -0.9827 3186878 PK04_095314 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NC6CC6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P19 compound treatment 8.6169506E7 -6.71E7 -1.76 9.074344E7 -6.86E7 -1.93 -2.6093 -0.9988 3187513 PK04_095315 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P20 compound treatment 9.2119413E7 -6.11E7 -1.6 9.3836582E7 -6.55E7 -1.85 -2.4376 -0.9975 3068271 PK04_095316 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCc6ccccc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P21 compound treatment 8.9728734E7 -6.35E7 -1.66 9.0744449E7 -6.86E7 -1.93 -2.5434 -0.9972 3068008 PK04_095317 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P22 compound treatment 9.9125854E7 -5.41E7 -1.42 1.01365815E8 -5.8E7 -1.63 -2.1579 -0.9975 3068262 PK04_095318 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P23 compound treatment 1.6897461E8 1.57E7 0.41 1.78577951E8 1.92E7 0.54 0.6736 0.9909 3068469 PK04_095319 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2095 P24 compound treatment 1.13937141E8 -3.93E7 -1.03 1.19370117E8 -4.0E7 -1.13 -1.5249 -0.999 3186794 PK04_095320 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A01 compound treatment 1.8545705E8 3.49E7 0.91 1.76454369E8 5680000.0 0.16 0.7594 0.8186 3186490 PK04_096001 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A02 compound treatment 2.07301662E8 5.68E7 1.49 2.18935361E8 4.82E7 1.36 2.0102 0.999 3186641 PK04_096002 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A03 compound treatment 1.00878088E8 -4.97E7 -1.3 1.03308573E8 -6.75E7 -1.9 -2.2637 -0.9828 3068261 PK04_096003 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A04 compound treatment 2.03731982E8 5.32E7 1.39 2.19934337E8 4.92E7 1.39 1.9641 1.0 3186971 PK04_096004 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A05 compound treatment 1.85993547E8 3.54E7 0.93 2.05961142E8 3.52E7 0.99 1.3573 0.9994 3186883 PK04_096005 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A06 compound treatment 1.00888058E8 -4.97E7 -1.3 1.07023619E8 -6.37E7 -1.8 -2.1895 -0.9874 3068309 PK04_096006 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A07 compound treatment 9.4580936E7 -5.6E7 -1.47 1.06456546E8 -6.43E7 -1.81 -2.3175 -0.9944 3186716 PK04_096007 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A08 compound treatment 1.73237646E8 2.27E7 0.59 1.7305517E8 2280000.0 0.06 0.4655 0.7792 3068367 PK04_096008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)Sc6ccc(C)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A09 compound treatment 1.80602937E8 3.01E7 0.79 1.95009191E8 2.42E7 0.68 1.0393 0.9975 3068224 PK04_096009 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A10 compound treatment 1.77584136E8 2.7E7 0.71 2.00855956E8 3.01E7 0.85 1.0999 0.996 3186633 PK04_096010 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5C(F)(F)F)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A11 compound treatment 1.87696598E8 3.71E7 0.97 2.11785258E8 4.1E7 1.16 1.5049 0.9963 3186986 PK04_096011 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A12 compound treatment 1.82964745E8 3.24E7 0.85 2.04273696E8 3.35E7 0.94 1.2676 0.9986 3186640 PK04_096012 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A13 mock treatment 1.81946848E8 3.14E7 0.82 2.13421416E8 4.27E7 1.2 1.4311 0.9828 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A14 mock treatment 1.78615484E8 2.81E7 0.73 2.01356569E8 3.06E7 0.86 1.129 0.9968 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A15 compound treatment 1.85405556E8 3.49E7 0.91 2.00342737E8 2.96E7 0.83 1.2345 0.999 3186881 PK04_096013 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A16 compound treatment 1.1535101E8 -3.52E7 -0.92 1.1016096E8 -6.06E7 -1.71 -1.8592 -0.958 3186790 PK04_096014 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A17 compound treatment 1.81607698E8 3.11E7 0.81 2.04639563E8 3.39E7 0.95 1.2498 0.9968 3186485 PK04_096015 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A18 compound treatment 9.7048849E7 -5.35E7 -1.4 1.0958259E8 -6.12E7 -1.72 -2.2095 -0.9947 3186802 PK04_096016 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A19 compound treatment 1.82701834E8 3.22E7 0.84 2.11505665E8 4.07E7 1.15 1.4069 0.9884 3068405 PK04_096017 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A20 compound treatment 1.85312908E8 3.48E7 0.91 2.06944823E8 3.62E7 1.02 1.3643 0.9984 3068141 PK04_096018 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A21 compound treatment 1.90672089E8 4.01E7 1.05 2.07599327E8 3.68E7 1.04 1.4765 1.0 3186624 PK04_096019 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5OC)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A22 compound treatment 1.97709723E8 4.72E7 1.23 2.15982874E8 4.52E7 1.27 1.7739 0.9999 3068200 PK04_096020 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCCN(C)C)C4=O)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A23 compound treatment 2.07317406E8 5.68E7 1.49 2.19211061E8 4.84E7 1.37 2.016 0.9991 3068358 PK04_096021 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 A24 compound treatment 2.28572806E8 7.8E7 2.04 2.44741086E8 7.4E7 2.08 2.9182 0.9999 3068371 PK04_096022 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B01 compound treatment 2.05448618E8 5.49E7 1.44 2.25566892E8 5.48E7 1.54 2.1081 0.9994 3187511 PK04_096023 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCC(F)(F)F)c3ccc(cc3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B02 compound treatment 1.77983602E8 2.74E7 0.72 1.93792861E8 2.3E7 0.65 0.9666 0.9987 3187030 PK04_096024 OCCCc1cc[n+](Cc2cccc(OC(F)(F)F)c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B03 compound treatment 1.65577511E8 1.5E7 0.39 1.78445501E8 7670000.0 0.22 0.4311 0.9603 3187169 PK04_096025 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B04 compound treatment 1.5508311E8 4530000.0 0.12 1.80154425E8 9380000.0 0.26 0.2709 0.9347 3068853 PK04_096026 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B05 compound treatment 1.57514835E8 6970000.0 0.18 1.74788425E8 4020000.0 0.11 0.209 0.9737 3068457 PK04_096027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B06 compound treatment 1.50553704E8 5380.0 0.0 1.70971826E8 201000.0 0.01 0.0041 0.7245 3068854 PK04_096028 C[n+]1ccc2ccc(O)cc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B07 compound treatment 1.65795994E8 1.52E7 0.4 1.8681022E8 1.6E7 0.45 0.6018 0.9981 3187352 PK04_096029 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCCN4CCOCC4)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B08 compound treatment 1.45086196E8 -5460000.0 -0.14 1.67445642E8 -3330000.0 -0.09 -0.1674 -0.979 3187112 PK04_096030 COc1cc2CC[N+](=Cc2cc1O)Cc3cc4OCOc4cc3Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B09 compound treatment 1.67735831E8 1.72E7 0.45 1.88600841E8 1.78E7 0.5 0.6734 0.9985 3068505 PK04_096031 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B10 compound treatment 1.53367023E8 2820000.0 0.07 1.67316388E8 -3450000.0 -0.1 -0.0167 -0.1364 3068855 PK04_096032 C[n+]1ccc(CCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B11 compound treatment 1.49916474E8 -632000.0 -0.02 1.70529227E8 -242000.0 -0.01 -0.0165 -0.923 3068374 PK04_096033 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B12 compound treatment 1.04727208E8 -4.58E7 -1.2 1.14540856E8 -5.62E7 -1.58 -1.9686 -0.9906 3187113 PK04_096034 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C=C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B13 mock treatment 1.51555729E8 1010000.0 0.03 1.74975969E8 4210000.0 0.12 0.1024 0.8438 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B14 mock treatment 1.55168028E8 4620000.0 0.12 1.77602758E8 6830000.0 0.19 0.2216 0.9749 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B15 compound treatment 1.52933059E8 2380000.0 0.06 1.85776138E8 1.5E7 0.42 0.3431 0.8028 3187255 PK04_096035 COCCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B16 compound treatment 1.58340121E8 7790000.0 0.2 1.80362055E8 9590000.0 0.27 0.3353 0.9904 3068856 PK04_096036 Oc1ccc2cc[n+](Cc3sc4ccccc4c3Cl)cc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B17 compound treatment 1.54675874E8 4130000.0 0.11 1.77633732E8 6860000.0 0.19 0.2132 0.9622 3068608 PK04_096037 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B18 compound treatment 7.3682673E7 -7.69E7 -2.01 8.4603491E7 -8.62E7 -2.43 -3.1398 -0.9956 3187114 PK04_096038 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C5CC5)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B19 compound treatment 1.57026605E8 6480000.0 0.17 1.85941306E8 1.52E7 0.43 0.4222 0.918 3187171 PK04_096039 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B20 compound treatment 1.62509688E8 1.2E7 0.31 1.7182892E8 1060000.0 0.03 0.2425 0.771 3068857 PK04_096040 OCCCc1cc[n+](Cc2ccc(o2)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B21 compound treatment 1.71348707E8 2.08E7 0.54 1.90562414E8 1.98E7 0.56 0.7794 0.9999 3068424 PK04_096041 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B22 compound treatment 1.59829364E8 9280000.0 0.24 1.81738467E8 1.1E7 0.31 0.3903 0.9929 3187115 PK04_096042 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B23 compound treatment 1.81396821E8 3.08E7 0.81 1.81686965E8 1.09E7 0.31 0.7885 0.9125 3187072 PK04_096043 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 B24 compound treatment 2.03523177E8 5.3E7 1.39 2.13962949E8 4.32E7 1.22 1.8412 0.9979 3187116 PK04_096044 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)c3cccs3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C01 compound treatment 1.93212376E8 4.27E7 1.12 2.04776333E8 3.4E7 0.96 1.4673 0.9971 3068218 PK04_096045 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C02 compound treatment 1.68543539E8 1.8E7 0.47 1.78149947E8 7380000.0 0.21 0.4801 0.9324 3186566 PK04_096046 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C03 compound treatment 1.53702769E8 3150000.0 0.08 1.59330561E8 -1.14E7 -0.32 -0.1696 -0.5095 3186549 PK04_096047 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C04 compound treatment 9.1743339E7 -5.88E7 -1.54 9.8441177E7 -7.23E7 -2.04 -2.5297 -0.9904 3186726 PK04_096048 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C05 compound treatment 8.8064477E7 -6.25E7 -1.64 9.745703E7 -7.33E7 -2.07 -2.6175 -0.9933 3186792 PK04_096049 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C06 compound treatment 1.45723248E8 -4830000.0 -0.13 1.70388467E8 -382000.0 -0.01 -0.0969 -0.7647 3186987 PK04_096050 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C07 compound treatment 9.1272549E7 -5.93E7 -1.55 9.7642119E7 -7.31E7 -2.06 -2.5544 -0.9902 3068275 PK04_096051 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C08 compound treatment 1.37289359E8 -1.33E7 -0.35 1.5031315E8 -2.05E7 -0.58 -0.6531 -0.9705 3186560 PK04_096052 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C09 compound treatment 1.27818626E8 -2.27E7 -0.59 1.38877547E8 -3.19E7 -0.9 -1.0562 -0.9799 3068147 PK04_096053 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C10 compound treatment 1.58517992E8 7970000.0 0.21 1.69747862E8 -1020000.0 -0.03 0.1271 0.6037 3186976 PK04_096054 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C11 mock treatment 1.55540812E8 4990000.0 0.13 1.77430094E8 6660000.0 0.19 0.2251 0.9844 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C12 mock treatment 1.5683667E8 6290000.0 0.16 1.81625774E8 1.09E7 0.31 0.3327 0.9578 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C13 compound treatment 1.49790166E8 -758000.0 -0.02 1.71563505E8 793000.0 0.02 0.0018 0.059 3186974 PK04_096055 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C14 compound treatment 1.46911064E8 -3640000.0 -0.1 1.72344215E8 1570000.0 0.04 -0.036 -0.3425 3186876 PK04_096056 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C15 mock treatment 1.47790664E8 -2760000.0 -0.07 1.70854349E8 83500.0 0.0 -0.0494 -0.6837 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C16 mock treatment 1.43534241E8 -7010000.0 -0.18 1.69460968E8 -1310000.0 -0.04 -0.1559 -0.8326 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C17 compound treatment 1.58672128E8 8120000.0 0.21 1.76803442E8 6030000.0 0.17 0.2706 0.9938 3186553 PK04_096057 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C18 compound treatment 1.46817037E8 -3730000.0 -0.1 1.7252555E8 1750000.0 0.05 -0.0341 -0.3115 3186634 PK04_096058 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C19 compound treatment 1.44615317E8 -5930000.0 -0.16 1.64947086E8 -5820000.0 -0.16 -0.2259 -0.9996 3186638 PK04_096059 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C20 compound treatment 1.52982015E8 2430000.0 0.06 1.77576292E8 6810000.0 0.19 0.1807 0.894 3068219 PK04_096060 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C21 compound treatment 1.57304514E8 6760000.0 0.18 1.76971185E8 6200000.0 0.17 0.2486 1.0 3068151 PK04_096061 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C22 compound treatment 1.62715137E8 1.22E7 0.32 1.79250239E8 8480000.0 0.24 0.3942 0.99 3068158 PK04_096062 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C23 compound treatment 9.53318E7 -5.52E7 -1.45 9.9033518E7 -7.17E7 -2.02 -2.4515 -0.9865 3186800 PK04_096063 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 C24 compound treatment 1.94362205E8 4.38E7 1.15 2.06235281E8 3.55E7 1.0 1.5177 0.9976 3068376 PK04_096064 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D01 compound treatment 1.82850096E8 3.23E7 0.85 2.03127251E8 3.24E7 0.91 1.2427 0.9993 3068407 PK04_096065 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D02 compound treatment 1.55771634E8 5220000.0 0.14 1.55550477E8 -1.52E7 -0.43 -0.2066 -0.4589 3187117 PK04_096066 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D03 compound treatment 1.65005496E8 1.45E7 0.38 1.77130573E8 6360000.0 0.18 0.3943 0.9417 3187274 PK04_096067 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D04 compound treatment 1.44725668E8 -5820000.0 -0.15 1.65418276E8 -5350000.0 -0.15 -0.2144 -1.0 3068858 PK04_096068 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C=C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D05 compound treatment 1.4808006E8 -2470000.0 -0.06 1.66120469E8 -4650000.0 -0.13 -0.1384 -0.9469 3187075 PK04_096069 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D06 compound treatment 1.6183858E8 1.13E7 0.3 1.87202049E8 1.64E7 0.46 0.5364 0.9765 3187118 PK04_096070 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D07 compound treatment 1.54087089E8 3540000.0 0.09 1.71703701E8 933000.0 0.03 0.0841 0.8733 3068634 PK04_096071 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D08 compound treatment 1.33038438E8 -1.75E7 -0.46 1.45760297E8 -2.5E7 -0.7 -0.8225 -0.9783 3068859 PK04_096072 OCc1ccc(cc1)c2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D09 compound treatment 8.2609228E7 -6.79E7 -1.78 9.1897852E7 -7.89E7 -2.22 -2.8292 -0.9939 3067975 PK04_096073 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D10 compound treatment 1.49721198E8 -827000.0 -0.02 1.72743163E8 1970000.0 0.06 0.024 0.4022 3068860 PK04_096074 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D11 mock treatment 1.44559293E8 -5990000.0 -0.16 1.72403209E8 1630000.0 0.05 -0.0783 -0.4794 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D12 mock treatment 1.52502659E8 1950000.0 0.05 1.81697787E8 1.09E7 0.31 0.2539 0.8134 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D13 compound treatment 1.51530634E8 982000.0 0.03 1.72341878E8 1570000.0 0.04 0.0495 0.9666 3187429 PK04_096075 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D14 compound treatment 1.40890772E8 -9660000.0 -0.25 1.66242389E8 -4530000.0 -0.13 -0.269 -0.9499 3187119 PK04_096076 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D15 mock treatment 1.47569915E8 -2980000.0 -0.08 1.70815542E8 44700.0 0.0 -0.0542 -0.6956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D16 mock treatment 1.60944646E8 1.04E7 0.27 1.81716321E8 1.09E7 0.31 0.4105 0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D17 compound treatment 1.52020812E8 1470000.0 0.04 1.73867971E8 3100000.0 0.09 0.089 0.9325 3187348 PK04_096077 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D18 compound treatment 1.54367341E8 3820000.0 0.1 1.85061892E8 1.43E7 0.4 0.3555 0.8566 3068861 PK04_096078 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C4CC4)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D19 compound treatment 1.52616812E8 2070000.0 0.05 1.80345033E8 9570000.0 0.27 0.2291 0.8324 3187354 PK04_096079 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D20 compound treatment 1.50942142E8 394000.0 0.01 1.74690714E8 3920000.0 0.11 0.0854 0.7698 3187120 PK04_096080 OCc1ccc(cc1)c2cc[n+](Cc3sc4ccccc4c3Cl)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D21 compound treatment 1.50849128E8 301000.0 0.01 1.75100397E8 4330000.0 0.12 0.0918 0.7512 3187433 PK04_096081 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D22 compound treatment 1.63361163E8 1.28E7 0.34 1.77673408E8 6900000.0 0.19 0.3747 0.9664 3068862 PK04_096082 COc1cc2CCN(C)C(C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D23 compound treatment 1.64321509E8 1.38E7 0.36 1.8328173E8 1.25E7 0.35 0.5042 0.9999 3068462 PK04_096083 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 D24 compound treatment 9.9100407E7 -5.14E7 -1.35 1.06216705E8 -6.46E7 -1.82 -2.2386 -0.989 3187121 PK04_096084 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E01 mock treatment 1.84387011E8 3.38E7 0.89 1.94539109E8 2.38E7 0.67 1.1 0.9905 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E02 mock treatment 1.76013245E8 2.55E7 0.67 1.83593704E8 1.28E7 0.36 0.7269 0.9586 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E03 compound treatment 1.29851005E8 -2.07E7 -0.54 1.3569509E8 -3.51E7 -0.99 -1.082 -0.9599 3186708 PK04_096085 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E04 compound treatment 1.19305169E8 -3.12E7 -0.82 1.28321041E8 -4.24E7 -1.2 -1.4242 -0.9828 3186710 PK04_096086 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E05 compound treatment 1.52908787E8 2360000.0 0.06 1.76620782E8 5850000.0 0.16 0.1603 0.9103 3186888 PK04_096087 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E06 compound treatment 1.59683467E8 9140000.0 0.24 1.77223608E8 6450000.0 0.18 0.2977 0.9909 3186565 PK04_096088 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E07 compound treatment 1.53655272E8 3110000.0 0.08 1.76079176E8 5310000.0 0.15 0.1633 0.959 3186983 PK04_096089 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E08 compound treatment 1.61535237E8 1.1E7 0.29 1.81782643E8 1.1E7 0.31 0.4228 0.9993 3067581 PK04_096090 CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E09 mock treatment 1.49406438E8 -1140000.0 -0.03 1.76363891E8 5590000.0 0.16 0.0903 0.563 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E10 mock treatment 1.54484987E8 3940000.0 0.1 1.80544739E8 9770000.0 0.28 0.2676 0.9101 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E11 compound treatment 8.9231429E7 -6.13E7 -1.61 9.6599683E7 -7.42E7 -2.09 -2.6129 -0.9915 3186717 PK04_096091 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E12 compound treatment 1.58537234E8 7990000.0 0.21 1.81549951E8 1.08E7 0.3 0.3627 0.9834 3068221 PK04_096092 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E13 compound treatment 8.1620812E7 -6.89E7 -1.8 9.3220599E7 -7.76E7 -2.19 -2.8211 -0.9955 3068273 PK04_096093 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E14 compound treatment 1.53034945E8 2490000.0 0.07 1.79497528E8 8730000.0 0.25 0.2199 0.8645 3068377 PK04_096094 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E15 compound treatment 1.48409132E8 -2140000.0 -0.06 1.77276474E8 6510000.0 0.18 0.09 0.4697 3068408 PK04_096095 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E16 compound treatment 1.52014355E8 1470000.0 0.04 1.79093922E8 8320000.0 0.23 0.193 0.812 3186635 PK04_096096 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E17 mock treatment 1.54681956E8 4130000.0 0.11 1.82099724E8 1.13E7 0.32 0.3023 0.8967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E18 mock treatment 1.5684967E8 6300000.0 0.16 1.82348346E8 1.16E7 0.33 0.3473 0.9501 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E19 compound treatment 8.6618382E7 -6.39E7 -1.67 9.27355E7 -7.8E7 -2.2 -2.7383 -0.9909 3186791 PK04_096097 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E20 compound treatment 1.59830669E8 9280000.0 0.24 1.80988097E8 1.02E7 0.29 0.3754 0.9964 3068233 PK04_096098 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E21 compound treatment 9.200677E7 -5.85E7 -1.53 9.505193E7 -7.57E7 -2.13 -2.5924 -0.9868 3186719 PK04_096099 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)Sc6ccc(C)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E22 compound treatment 9.1858749E7 -5.87E7 -1.54 9.4876371E7 -7.59E7 -2.14 -2.5986 -0.9868 3186789 PK04_096100 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E23 compound treatment 9.1862287E7 -5.87E7 -1.54 9.7018555E7 -7.38E7 -2.08 -2.5559 -0.9889 3186803 PK04_096101 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 E24 compound treatment 1.0383952E8 -4.67E7 -1.22 9.7321321E7 -7.34E7 -2.07 -2.3282 -0.9685 3186711 PK04_096102 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F01 mock treatment 1.07452293E8 -4.31E7 -1.13 2.02098374E8 3.13E7 0.88 -0.1734 -0.1211 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F02 mock treatment 1.73386684E8 2.28E7 0.6 1.89393763E8 1.86E7 0.52 0.7938 0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F03 compound treatment 1.68546769E8 1.8E7 0.47 1.72839595E8 2070000.0 0.06 0.3744 0.7886 3068521 PK04_096103 CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F04 compound treatment 1.63333112E8 1.28E7 0.33 1.81937848E8 1.12E7 0.31 0.4592 0.9995 3187122 PK04_096104 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F05 compound treatment 1.59426443E8 8880000.0 0.23 1.79982501E8 9210000.0 0.26 0.3479 0.9985 3068461 PK04_096105 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F06 compound treatment 1.24499594E8 -2.6E7 -0.68 1.52586921E8 -1.82E7 -0.51 -0.8445 -0.9901 3068863 PK04_096106 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5ccc(CN6CCCC6)cc5)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F07 compound treatment 1.5892192E8 8370000.0 0.22 1.78356535E8 7590000.0 0.21 0.3061 0.9999 3187077 PK04_096107 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F08 compound treatment 1.53272563E8 2720000.0 0.07 1.78122895E8 7350000.0 0.21 0.1969 0.8987 3187123 PK04_096108 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CN5CCCC5)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F09 mock treatment 1.55119727E8 4570000.0 0.12 1.78238593E8 7470000.0 0.21 0.2334 0.9642 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F10 mock treatment 1.44425309E8 -6120000.0 -0.16 1.7642135E8 5650000.0 0.16 -7.0E-4 -0.0033 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F11 compound treatment 1.49019536E8 -1530000.0 -0.04 1.74113235E8 3340000.0 0.09 0.0383 0.3743 3187438 PK04_096109 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F12 compound treatment 1.28881898E8 -2.17E7 -0.57 1.44053079E8 -2.67E7 -0.75 -0.9334 -0.9902 3187124 PK04_096110 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OC)c3ccc(CO)cc3)c4cccs4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F13 compound treatment 1.47785992E8 -2760000.0 -0.07 1.69467695E8 -1300000.0 -0.04 -0.0771 -0.9506 3068559 PK04_096111 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4CCCCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F14 compound treatment 1.51934189E8 1390000.0 0.04 1.73738138E8 2970000.0 0.08 0.0848 0.9301 3068864 PK04_096112 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F15 compound treatment 8.339559E7 -6.72E7 -1.76 9.2274191E7 -7.85E7 -2.21 -2.8072 -0.9935 3186801 PK04_096113 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F16 compound treatment 1.33114604E8 -1.74E7 -0.46 1.67626416E8 -3140000.0 -0.09 -0.3854 -0.8289 3187125 PK04_096114 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F17 mock treatment 1.52232274E8 1680000.0 0.04 1.81081638E8 1.03E7 0.29 0.2366 0.8052 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F18 mock treatment 1.55291423E8 4740000.0 0.12 1.76820082E8 6050000.0 0.17 0.2083 0.9879 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F19 compound treatment 8.7946727E7 -6.26E7 -1.64 9.5592586E7 -7.52E7 -2.12 -2.6568 -0.9919 3186718 PK04_096115 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NC6CC6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F20 compound treatment 1.44738309E8 -5810000.0 -0.15 1.61112419E8 -9660000.0 -0.27 -0.3 -0.9622 3068865 PK04_096116 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4cccs4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F21 compound treatment 1.29814792E8 -2.07E7 -0.54 1.41023073E8 -2.97E7 -0.84 -0.9765 -0.9779 3067569 PK04_096117 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F22 compound treatment 1.56894094E8 6350000.0 0.17 1.70497339E8 -274000.0 -0.01 0.112 0.6736 3187126 PK04_096118 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C=C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F23 compound treatment 1.64311493E8 1.38E7 0.36 1.7987661E8 9110000.0 0.26 0.4362 0.9862 3068643 PK04_096119 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 F24 compound treatment 2.01305723E8 5.08E7 1.33 2.15460759E8 4.47E7 1.26 1.83 0.9996 3187127 PK04_096120 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)c5cccs5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G01 compound treatment 1.85657142E8 3.51E7 0.92 1.96591537E8 2.58E7 0.73 1.1644 0.9933 3186434 PK04_096121 CN(C)CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G02 compound treatment 1.77972564E8 2.74E7 0.72 1.71277936E8 507000.0 0.01 0.5177 0.721 3067602 PK04_096122 CC(C)N1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G03 mock treatment 1.7029005E8 1.97E7 0.52 1.72092701E8 1320000.0 0.04 0.3918 0.7561 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G04 mock treatment 1.66538017E8 1.6E7 0.42 1.81977933E8 1.12E7 0.32 0.5193 0.9904 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G05 compound treatment 1.1167436E8 -3.89E7 -1.02 1.19908447E8 -5.09E7 -1.43 -1.7331 -0.9859 3068238 PK04_096123 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G06 compound treatment 8.6511631E7 -6.4E7 -1.68 9.4052851E7 -7.67E7 -2.16 -2.714 -0.9921 3068315 PK04_096124 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G07 compound treatment 8.4347358E7 -6.62E7 -1.73 9.3691333E7 -7.71E7 -2.17 -2.7613 -0.9937 3186805 PK04_096125 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G08 compound treatment 1.03576069E8 -4.7E7 -1.23 1.18477897E8 -5.23E7 -1.47 -1.9115 -0.9959 3186712 PK04_096126 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G09 compound treatment 1.49853993E8 -694000.0 -0.02 1.74462097E8 3690000.0 0.1 0.0607 0.5748 3068360 PK04_096127 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G10 compound treatment 1.58343876E8 7800000.0 0.2 1.7731297E8 6540000.0 0.18 0.2747 0.9987 3186431 PK04_096128 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N([C@@H]3c4ccc(CO)cc24)C5CCCCC5)c6ccc(cc6)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G11 compound treatment 1.14770079E8 -3.58E7 -0.94 1.25163349E8 -4.56E7 -1.29 -1.571 -0.9879 3186642 PK04_096129 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G12 compound treatment 1.46668236E8 -3880000.0 -0.1 1.70571518E8 -199000.0 -0.01 -0.0758 -0.7451 3068326 PK04_096130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G13 compound treatment 1.55481362E8 4930000.0 0.13 1.76273186E8 5500000.0 0.16 0.201 0.9959 3186484 PK04_096131 CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G14 compound treatment 1.4262444E8 -7920000.0 -0.21 1.67722754E8 -3050000.0 -0.09 -0.2074 -0.9238 3068146 PK04_096132 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G15 compound treatment 1.51175784E8 627000.0 0.02 1.75370096E8 4600000.0 0.13 0.1033 0.7904 3068195 PK04_096133 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C6CC6)C4=O)c7ccccc7C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G16 compound treatment 8.511367E7 -6.54E7 -1.71 9.4687588E7 -7.61E7 -2.14 -2.7273 -0.9938 3068279 PK04_096134 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G17 compound treatment 1.65105319E8 1.46E7 0.38 1.84416941E8 1.36E7 0.38 0.5414 1.0 3068328 PK04_096135 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G18 compound treatment 8.777376E7 -6.28E7 -1.64 9.678664E7 -7.4E7 -2.08 -2.6362 -0.9931 3068311 PK04_096136 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G19 mock treatment 1.58605095E8 8060000.0 0.21 1.7858292E8 7810000.0 0.22 0.3048 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G20 mock treatment 1.61591336E8 1.1E7 0.29 1.81425543E8 1.07E7 0.3 0.4167 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G21 compound treatment 9.222075E7 -5.83E7 -1.53 9.7493972E7 -7.33E7 -2.06 -2.5398 -0.989 3068284 PK04_096137 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G22 compound treatment 1.35260292E8 -1.53E7 -0.4 1.39378746E8 -3.14E7 -0.88 -0.9085 -0.9357 3186501 PK04_096138 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G23 compound treatment 1.62865711E8 1.23E7 0.32 1.67508463E8 -3260000.0 -0.09 0.163 0.4861 3186555 PK04_096139 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 G24 compound treatment 1.86485308E8 3.59E7 0.94 2.018232E8 3.11E7 0.88 1.284 0.9993 3186877 PK04_096140 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H01 compound treatment 1.77202668E8 2.67E7 0.7 1.91176986E8 2.04E7 0.58 0.9 0.9954 3186629 PK04_096141 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H02 compound treatment 1.33829185E8 -1.67E7 -0.44 1.41030185E8 -2.97E7 -0.84 -0.9021 -0.9541 3068866 PK04_096142 OCc1ccc(cc1)c2cc[n+](Cc3cc4OCOc4cc3Br)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H03 mock treatment 1.68283552E8 1.77E7 0.46 1.7572448E8 4950000.0 0.14 0.427 0.8808 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H04 mock treatment 1.57036257E8 6490000.0 0.17 1.75123084E8 4350000.0 0.12 0.2068 0.9872 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H05 compound treatment 1.45563767E8 -4980000.0 -0.13 1.71935998E8 1170000.0 0.03 -0.069 -0.5132 3186432 PK04_096143 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H06 compound treatment 1.35339002E8 -1.52E7 -0.4 1.51702249E8 -1.91E7 -0.54 -0.6615 -0.9891 3068867 PK04_096144 OCc1ccc(cc1)c2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H07 compound treatment 1.48711178E8 -1840000.0 -0.05 1.6915853E8 -1610000.0 -0.05 -0.0661 -0.9996 3187128 PK04_096145 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3C4CC5CC(C4)CC3C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H08 compound treatment 1.41197629E8 -9350000.0 -0.24 1.64769684E8 -6000000.0 -0.17 -0.2927 -0.9837 3068868 PK04_096146 COc1cc2CC[N+](=Cc2cc1O)Cc3sc4ccccc4c3Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H09 compound treatment 1.36896169E8 -1.37E7 -0.36 1.57846194E8 -1.29E7 -0.36 -0.5102 -1.0 3186637 PK04_096147 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H10 compound treatment 1.24184391E8 -2.64E7 -0.69 1.43187293E8 -2.76E7 -0.78 -1.0376 -0.9982 3187129 PK04_096148 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C4CC4)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H11 compound treatment 1.2438199E8 -2.62E7 -0.68 1.47623728E8 -2.31E7 -0.65 -0.9456 -0.9997 3187130 PK04_096149 CC1(C)OB(OC1(C)C)/C=C\CC(OC(=O)c2ccncc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H12 compound treatment 1.4480402E8 -5740000.0 -0.15 1.66599948E8 -4170000.0 -0.12 -0.1894 -0.9926 3187131 PK04_096150 C[n+]1ccc(cc1)c2ccc(CO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H13 compound treatment 1.15477617E8 -3.51E7 -0.92 1.32259598E8 -3.85E7 -1.09 -1.4165 -0.9965 3068898 PK04_096151 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)C)c2ccccc2)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H14 compound treatment 1.45308103E8 -5240000.0 -0.14 1.6650095E8 -4270000.0 -0.12 -0.1821 -0.9979 3187132 PK04_096152 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H15 compound treatment 1.46505008E8 -4040000.0 -0.11 1.69785599E8 -985000.0 -0.03 -0.0945 -0.8634 3187133 PK04_096153 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)C)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H16 compound treatment 1.38924868E8 -1.16E7 -0.3 1.61789477E8 -8980000.0 -0.25 -0.3941 -0.9958 3187134 PK04_096154 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C2)c6cccs6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H17 compound treatment 1.50218061E8 -330000.0 -0.01 1.69020695E8 -1750000.0 -0.05 -0.041 -0.8186 3068899 PK04_096155 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)c3ccncc3)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H18 compound treatment 1.12880573E8 -3.77E7 -0.99 1.33661752E8 -3.71E7 -1.05 -1.4367 -0.9996 3068900 PK04_096156 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C5CC5)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H19 mock treatment 1.60498365E8 9950000.0 0.26 1.78925592E8 8150000.0 0.23 0.3467 0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H20 mock treatment 1.58154479E8 7610000.0 0.2 1.76238529E8 5470000.0 0.15 0.2497 0.992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H21 compound treatment 5.2308554E7 -9.82E7 -2.57 8.294506E7 -8.78E7 -2.47 -3.5685 -0.9998 3187204 PK04_096157 CC(C)(C)OC(=O)COc1cccc(c1)C(=O)CCN2CCOCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H22 compound treatment 1.68879543E8 1.83E7 0.48 1.73447194E8 2680000.0 0.08 0.3926 0.8083 3187205 PK04_096158 OCCCc1cc[n+](Cc2cc3OCOc3cc2Br)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H23 compound treatment 1.7212905E8 2.16E7 0.56 1.82259512E8 1.15E7 0.32 0.6284 0.9651 3068901 PK04_096159 COc1ccc(/C=C/C(=O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 H24 compound treatment 1.85265053E8 3.47E7 0.91 1.91969915E8 2.12E7 0.6 1.065 0.9793 3187206 PK04_096160 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I01 compound treatment 9.9642543E7 -5.09E7 -1.33 1.03414726E8 -6.74E7 -1.9 -2.2844 -0.985 3186796 PK04_096161 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I02 compound treatment 1.66640721E8 1.61E7 0.42 1.70747221E8 -23600.0 0.0 0.2974 0.706 3186628 PK04_096162 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I03 compound treatment 1.52479763E8 1930000.0 0.05 1.59151781E8 -1.16E7 -0.33 -0.1958 -0.5909 3186882 PK04_096163 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I04 compound treatment 9.1257113E7 -5.93E7 -1.55 9.7394585E7 -7.34E7 -2.07 -2.5596 -0.99 3186797 PK04_096164 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I05 mock treatment 1.51625084E8 1080000.0 0.03 1.69015969E8 -1750000.0 -0.05 -0.015 -0.2642 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I06 mock treatment 1.53966263E8 3420000.0 0.09 1.71467217E8 696000.0 0.02 0.0771 0.8422 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I07 compound treatment 1.5155141E8 1000000.0 0.03 1.73235752E8 2460000.0 0.07 0.0677 0.9115 3186430 PK04_096165 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(C5CC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I08 compound treatment 1.35384E8 -1.52E7 -0.4 1.54903662E8 -1.59E7 -0.45 -0.5969 -0.9982 3186557 PK04_096166 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I09 compound treatment 1.24012101E8 -2.65E7 -0.69 1.44750333E8 -2.6E7 -0.73 -1.0097 -0.9996 3186558 PK04_096167 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I10 compound treatment 8.3368098E7 -6.72E7 -1.76 9.0127674E7 -8.06E7 -2.27 -2.8504 -0.992 3068320 PK04_096168 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I11 compound treatment 1.42030657E8 -8520000.0 -0.22 1.70047376E8 -723000.0 -0.02 -0.1721 -0.7686 3068364 PK04_096169 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I12 compound treatment 1.13131982E8 -3.74E7 -0.98 1.27018237E8 -4.38E7 -1.23 -1.5644 -0.9935 3186489 PK04_096170 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I13 compound treatment 1.38396874E8 -1.22E7 -0.32 1.61294514E8 -9480000.0 -0.27 -0.4138 -0.9962 3186807 PK04_096171 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I14 compound treatment 8.0957577E7 -6.96E7 -1.82 8.5766625E7 -8.5E7 -2.4 -2.982 -0.9909 3068281 PK04_096172 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I15 compound treatment 1.49279502E8 -1270000.0 -0.03 1.5180953E8 -1.9E7 -0.53 -0.4013 -0.7496 3186567 PK04_096173 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I16 compound treatment 1.55980012E8 5430000.0 0.14 1.31888719E8 -3.89E7 -1.1 -0.6742 -0.6102 3068410 PK04_096174 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I17 compound treatment 1.4940937E8 -1140000.0 -0.03 1.63879226E8 -6890000.0 -0.19 -0.1584 -0.8062 3186973 PK04_096175 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I18 compound treatment 1.39434471E8 -1.11E7 -0.29 1.73752941E8 2980000.0 0.08 -0.1463 -0.4831 3068148 PK04_096176 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I19 compound treatment 1.42678735E8 -7870000.0 -0.21 1.78145386E8 7370000.0 0.21 0.0013 0.0044 3068239 PK04_096177 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I20 compound treatment 8.9047283E7 -6.15E7 -1.61 1.05420275E8 -6.54E7 -1.84 -2.4406 -0.9978 3068268 PK04_096178 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I21 mock treatment 1.65203062E8 1.47E7 0.38 1.9047887E8 1.97E7 0.56 0.664 0.9837 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I22 mock treatment 1.61942023E8 1.14E7 0.3 1.82096707E8 1.13E7 0.32 0.4366 0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I23 compound treatment 1.6792143E8 1.74E7 0.45 1.94776412E8 2.4E7 0.68 0.7999 0.9813 3186564 PK04_096179 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 I24 compound treatment 1.88163931E8 3.76E7 0.98 2.13129807E8 4.24E7 1.19 1.5403 0.9954 3068366 PK04_096180 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J01 compound treatment 2.8457142E7 -1.22E8 -3.2 2.8416266E7 -1.42E8 -4.01 -5.0965 -0.9937 1230870 PK04_096181 Oc1cccc(c1)C(=O)CCN2CCOCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J02 compound treatment 1.43404592E8 -7140000.0 -0.19 1.54160911E8 -1.66E7 -0.47 -0.4632 -0.919 3187207 PK04_096182 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)C3CC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J03 compound treatment 1.48767215E8 -1780000.0 -0.05 1.51065971E8 -1.97E7 -0.56 -0.4256 -0.7638 3068902 PK04_096183 COc1ccc(CC[C@H](O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J04 compound treatment 1.2997092E8 -2.06E7 -0.54 1.42753925E8 -2.8E7 -0.79 -0.9392 -0.9826 3187208 PK04_096184 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J05 mock treatment 1.43615833E8 -6930000.0 -0.18 1.63288632E8 -7480000.0 -0.21 -0.2774 -0.9972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J06 mock treatment 1.42976112E8 -7570000.0 -0.2 1.62479455E8 -8290000.0 -0.23 -0.3054 -0.9967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J07 compound treatment 1.34944988E8 -1.56E7 -0.41 1.53409566E8 -1.74E7 -0.49 -0.6348 -0.996 3187209 PK04_096185 CCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c5cccc(O)c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J08 compound treatment 1.07189751E8 -4.34E7 -1.13 1.19812204E8 -5.1E7 -1.44 -1.818 -0.9932 3068903 PK04_096186 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J09 compound treatment 1.47259737E8 -3290000.0 -0.09 1.67507176E8 -3260000.0 -0.09 -0.1259 -0.9995 1032549 PK04_096187 CCOC(=O)C1CCCCN1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J10 compound treatment 1.38090979E8 -1.25E7 -0.33 1.65983945E8 -4790000.0 -0.13 -0.326 -0.9237 3187210 PK04_096188 COc1cc2CCN(C)C(C=C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J11 compound treatment 1.47755756E8 -2790000.0 -0.07 1.67222705E8 -3550000.0 -0.1 -0.1224 -0.9881 3187211 PK04_096189 CCOC(=O)[C@@H]1CCCCN1C(=O)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J12 compound treatment 1.52983742E8 2440000.0 0.06 1.7099818E8 227000.0 0.01 0.0496 0.7743 3187212 PK04_096190 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4ccc(CN5CCCC5)cc4)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J13 compound treatment 1.42960613E8 -7590000.0 -0.2 1.68259702E8 -2510000.0 -0.07 -0.1905 -0.9034 3068904 PK04_096191 [O-][N+](=O)c1cc(Br)ccc1C(=O)NCc2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J14 compound treatment 1.35353965E8 -1.52E7 -0.4 1.60639975E8 -1.01E7 -0.29 -0.4831 -0.9868 3068905 PK04_096192 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C=C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J15 compound treatment 1.41434315E8 -9110000.0 -0.24 1.68209616E8 -2560000.0 -0.07 -0.2197 -0.8816 3187213 PK04_096193 CC(=O)Nc1cc(Br)ccc1C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J16 compound treatment 1.11937762E8 -3.86E7 -1.01 1.35218794E8 -3.56E7 -1.0 -1.4231 -1.0 3187214 PK04_096194 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5cccs5)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J17 compound treatment 1.50089049E8 -459000.0 -0.01 1.78924884E8 8150000.0 0.23 0.154 0.6692 3068906 PK04_096195 CC(=O)Nc1cc(Br)ccc1C(=O)NCc2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J18 compound treatment 1.26133893E8 -2.44E7 -0.64 1.55811816E8 -1.5E7 -0.42 -0.75 -0.9796 3187215 PK04_096196 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5cccs5)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J19 compound treatment 1.11692693E8 -3.89E7 -1.02 1.44880996E8 -2.59E7 -0.73 -1.2351 -0.9867 3068907 PK04_096197 Brc1ccc2c(=O)oc(nc2c1)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J20 compound treatment 4.3725919E7 -1.07E8 -2.8 2.8517309E7 -1.42E8 -4.01 -4.8119 -0.9845 3187216 PK04_096198 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4ccc(CN5CCCC5)cc4)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J21 mock treatment 1.58659282E8 8110000.0 0.21 1.7027527E8 -496000.0 -0.01 0.1403 0.6592 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J22 mock treatment 1.61584178E8 1.1E7 0.29 1.77044965E8 6270000.0 0.18 0.3293 0.9722 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J23 compound treatment 1.72986305E8 2.24E7 0.59 1.96429438E8 2.57E7 0.72 0.9266 0.9947 3068908 PK04_096199 Nc1cc(Br)ccc1C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 J24 compound treatment 1.61594858E8 1.1E7 0.29 1.80758072E8 9990000.0 0.28 0.4035 0.9999 3068910 PK04_096200 Oc1ccc2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K01 compound treatment 1.78412134E8 2.79E7 0.73 1.94068345E8 2.33E7 0.66 0.98 0.9986 3068198 PK04_096201 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(Cc6ccccc6)C4=O)c7ccccc7C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K02 compound treatment 1.55879525E8 5330000.0 0.14 1.61485275E8 -9290000.0 -0.26 -0.0864 -0.2912 3186870 PK04_096202 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K03 compound treatment 1.29331932E8 -2.12E7 -0.56 1.33234236E8 -3.75E7 -1.06 -1.1407 -0.9548 3068155 PK04_096203 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K04 compound treatment 1.52525006E8 1980000.0 0.05 1.75237777E8 4470000.0 0.13 0.1256 0.9228 3186875 PK04_096204 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K05 compound treatment 1.33098373E8 -1.74E7 -0.46 1.52159611E8 -1.86E7 -0.52 -0.6939 -0.9976 3068359 PK04_096205 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K06 compound treatment 1.43252701E8 -7300000.0 -0.19 1.51655104E8 -1.91E7 -0.54 -0.516 -0.9027 3186626 PK04_096206 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(F)(F)F)C4=O)c6ccccc6C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K07 mock treatment 1.41665694E8 -8880000.0 -0.23 1.49621917E8 -2.11E7 -0.6 -0.5858 -0.9158 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K08 mock treatment 1.36968578E8 -1.36E7 -0.36 1.60072161E8 -1.07E7 -0.3 -0.4645 -0.9966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K09 compound treatment 1.31388771E8 -1.92E7 -0.5 1.52710728E8 -1.81E7 -0.51 -0.7145 -1.0 3186869 PK04_096207 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K10 compound treatment 1.3898864E8 -1.16E7 -0.3 1.59206634E8 -1.16E7 -0.33 -0.4444 -0.9993 3068235 PK04_096208 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K11 compound treatment 1.45221294E8 -5330000.0 -0.14 1.62486221E8 -8280000.0 -0.23 -0.2637 -0.9697 3186487 PK04_096209 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(Cc7ccccc7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K12 compound treatment 1.4598623E8 -4560000.0 -0.12 1.64427665E8 -6340000.0 -0.18 -0.2108 -0.9808 3068411 PK04_096210 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K13 compound treatment 1.39520279E8 -1.1E7 -0.29 1.60592766E8 -1.02E7 -0.29 -0.4069 -1.0 3068329 PK04_096211 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K14 compound treatment 1.41269992E8 -9280000.0 -0.24 1.58046139E8 -1.27E7 -0.36 -0.4253 -0.982 3067608 PK04_096212 COCCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K15 mock treatment 1.38776879E8 -1.18E7 -0.31 1.62537632E8 -8230000.0 -0.23 -0.3819 -0.9902 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K16 mock treatment 1.42811158E8 -7740000.0 -0.2 1.68484106E8 -2290000.0 -0.06 -0.1888 -0.8882 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K17 compound treatment 1.45286979E8 -5260000.0 -0.14 1.66974796E8 -3800000.0 -0.11 -0.173 -0.9922 3186979 PK04_096213 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K18 compound treatment 1.40762826E8 -9790000.0 -0.26 1.69581067E8 -1190000.0 -0.03 -0.2048 -0.7929 3186636 PK04_096214 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K19 compound treatment 8.8150832E7 -6.24E7 -1.63 9.5297187E7 -7.55E7 -2.13 -2.6589 -0.9915 3186793 PK04_096215 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K20 compound treatment 1.55872441E8 5320000.0 0.14 1.73020546E8 2250000.0 0.06 0.1434 0.9364 3186637 PK04_096216 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K21 compound treatment 1.58769084E8 8220000.0 0.22 1.69641787E8 -1130000.0 -0.03 0.1297 0.5961 3067613 PK04_096217 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N(CC4(CC5CC6CC(C5)C4)C6)[C@@H]3c7ccc(CO)cc27)c8ccc(cc8)[N+](=O)[O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K22 compound treatment 1.54260982E8 3710000.0 0.1 1.73545731E8 2770000.0 0.08 0.124 0.9942 3186873 PK04_096218 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K23 mock treatment 1.67219404E8 1.67E7 0.44 1.54330172E8 -1.64E7 -0.46 -0.019 -0.0299 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 K24 mock treatment 1.84921064E8 3.44E7 0.9 1.99628971E8 2.89E7 0.81 1.2113 0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L01 compound treatment 1.70217846E8 1.97E7 0.51 1.86537174E8 1.58E7 0.44 0.6782 0.9973 3068940 PK04_096219 Cc1nc2cc(Br)ccc2c(=O)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L02 compound treatment 1.32836305E8 -1.77E7 -0.46 1.44096305E8 -2.67E7 -0.75 -0.8594 -0.973 3187217 PK04_096220 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5ccc(CN6CCCC6)cc5)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L03 compound treatment 1.58062711E8 7510000.0 0.2 1.76552587E8 5780000.0 0.16 0.2543 0.9956 3068941 PK04_096221 CC(C)c1nc2cc(Br)ccc2c(=O)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L04 compound treatment 1.26283842E8 -2.43E7 -0.64 1.37539174E8 -3.32E7 -0.94 -1.1113 -0.9821 3068942 PK04_096222 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L05 compound treatment 1.52105766E8 1560000.0 0.04 1.746502E8 3880000.0 0.11 0.1061 0.9096 3187218 PK04_096223 Cc1nc2cc(Br)ccc2c(=O)n1Cc3cccc(O)c3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L06 compound treatment 1.33396686E8 -1.72E7 -0.45 1.6038304E8 -1.04E7 -0.29 -0.5245 -0.9785 3068943 PK04_096224 COc1cc2CCN(C)C(c3cccs3)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L07 mock treatment 1.42744074E8 -7800000.0 -0.2 1.62775702E8 -8000000.0 -0.23 -0.3038 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L08 mock treatment 1.29785048E8 -2.08E7 -0.54 1.55041696E8 -1.57E7 -0.44 -0.6978 -0.9949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L09 compound treatment 1.14774521E8 -3.58E7 -0.94 1.31385235E8 -3.94E7 -1.11 -1.447 -0.9964 3187219 PK04_096225 Oc1cccc(CNC(=O)c2ccc(Br)cc2NC(=O)c3ccccc3)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L10 compound treatment 9.590059E7 -5.46E7 -1.43 1.16550125E8 -5.42E7 -1.53 -2.092 -0.9995 3187220 PK04_096226 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L11 compound treatment 1.36264658E8 -1.43E7 -0.37 1.53445861E8 -1.73E7 -0.49 -0.6096 -0.9913 3068944 PK04_096227 Oc1cccc(Cn2c(nc3cc(Br)ccc3c2=O)c4ccccc4)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L12 compound treatment 1.3379454E8 -1.68E7 -0.44 1.57546446E8 -1.32E7 -0.37 -0.5736 -0.9967 3187221 PK04_096228 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L13 compound treatment 1.28792269E8 -2.18E7 -0.57 1.54271689E8 -1.65E7 -0.46 -0.7315 -0.9949 1980253 PK04_096229 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2)/C#N)c(=O)n(c3ccccc3)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L14 compound treatment 9.7687457E7 -5.29E7 -1.38 1.20286099E8 -5.05E7 -1.42 -1.9844 -0.9999 3068945 PK04_096230 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3cccs3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L15 mock treatment 1.32359519E8 -1.82E7 -0.48 1.5860475E8 -1.22E7 -0.34 -0.5791 -0.987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L16 mock treatment 1.32877287E8 -1.77E7 -0.46 1.49086519E8 -2.17E7 -0.61 -0.7592 -0.9906 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L17 compound treatment 4.7177749E7 -1.03E8 -2.71 5.1087126E7 -1.2E8 -3.37 -4.2983 -0.994 3187222 PK04_096231 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L18 compound treatment 1.35360791E8 -1.52E7 -0.4 1.55241322E8 -1.55E7 -0.44 -0.5906 -0.9989 3187223 PK04_096232 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6cccs6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L19 compound treatment 1.17560197E8 -3.3E7 -0.86 1.32714264E8 -3.81E7 -1.07 -1.3689 -0.9942 3068946 PK04_096233 Cc1c(NC(=O)/C(=C/C=C/c2ccc(cc2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L20 compound treatment 1.4134756E8 -9200000.0 -0.24 1.52943549E8 -1.78E7 -0.5 -0.5255 -0.9433 3187224 PK04_096234 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5cccs5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L21 compound treatment 1.44675591E8 -5870000.0 -0.15 1.58614327E8 -1.22E7 -0.34 -0.3509 -0.9346 3068947 PK04_096235 CN(C)c1ccc(/C=C/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L22 compound treatment 1.5211349E8 1570000.0 0.04 1.66893011E8 -3880000.0 -0.11 -0.0483 -0.4139 3187225 PK04_096236 COc1cc2CCN(C)C(C3CC3)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L23 mock treatment 1.66307531E8 1.58E7 0.41 1.77991064E8 7220000.0 0.2 0.4356 0.947 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 L24 mock treatment 1.89104663E8 3.86E7 1.01 1.97804958E8 2.7E7 0.76 1.2524 0.9904 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M01 compound treatment 1.86649154E8 3.61E7 0.95 1.99223265E8 2.85E7 0.8 1.2352 0.9967 3186502 PK04_096237 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M02 compound treatment 9.7299829E7 -5.32E7 -1.39 1.18483869E8 -5.23E7 -1.47 -2.0275 -0.9996 3186497 PK04_096238 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC(C)C)c5ccccc5C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M03 compound treatment 1.46886757E8 -3660000.0 -0.1 1.62134942E8 -8640000.0 -0.24 -0.2399 -0.917 3068404 PK04_096239 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M04 compound treatment 9.6624499E7 -5.39E7 -1.41 1.13118042E8 -5.77E7 -1.62 -2.1469 -0.9975 3186643 PK04_096240 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M05 compound treatment 8.4751068E7 -6.58E7 -1.72 9.1480108E7 -7.93E7 -2.23 -2.7979 -0.9917 3186723 PK04_096241 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M06 compound treatment 1.3610014E8 -1.44E7 -0.38 1.44442308E8 -2.63E7 -0.74 -0.7921 -0.9511 3186868 PK04_096242 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M07 compound treatment 8.1845905E7 -6.87E7 -1.8 8.2347568E7 -8.84E7 -2.49 -3.0336 -0.9872 3186798 PK04_096243 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M08 compound treatment 7.9843272E7 -7.07E7 -1.85 8.9428103E7 -8.13E7 -2.29 -2.9296 -0.9944 3186799 PK04_096244 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M09 mock treatment 1.32518347E8 -1.8E7 -0.47 1.50607608E8 -2.02E7 -0.57 -0.7355 -0.9957 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M10 mock treatment 1.30744671E8 -1.98E7 -0.52 1.51457274E8 -1.93E7 -0.54 -0.7514 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M11 compound treatment 6.7231708E7 -8.33E7 -2.18 7.2130097E7 -9.86E7 -2.78 -3.5077 -0.9928 3186496 PK04_096245 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M12 compound treatment 1.42652079E8 -7900000.0 -0.21 1.59686503E8 -1.11E7 -0.31 -0.367 -0.9799 3068379 PK04_096246 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M13 mock treatment 1.36103483E8 -1.44E7 -0.38 1.55621343E8 -1.51E7 -0.43 -0.5692 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M14 mock treatment 1.33211962E8 -1.73E7 -0.45 1.53835919E8 -1.69E7 -0.48 -0.6583 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M15 compound treatment 1.28259136E8 -2.23E7 -0.58 1.48066343E8 -2.27E7 -0.64 -0.865 -0.9989 3186488 PK04_096247 CC(C)N1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M16 compound treatment 1.22059645E8 -2.85E7 -0.75 1.45527504E8 -2.52E7 -0.71 -1.0303 -0.9997 3186886 PK04_096248 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M17 compound treatment 1.39594014E8 -1.1E7 -0.29 1.52006344E8 -1.88E7 -0.53 -0.5767 -0.9587 3068154 PK04_096249 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M18 compound treatment 1.47966139E8 -2580000.0 -0.07 1.64497023E8 -6270000.0 -0.18 -0.1728 -0.913 3068369 PK04_096250 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M19 compound treatment 8.5717969E7 -6.48E7 -1.7 8.9473692E7 -8.13E7 -2.29 -2.82 -0.9891 3186727 PK04_096251 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M20 compound treatment 1.45158319E8 -5390000.0 -0.14 1.60394875E8 -1.04E7 -0.29 -0.3065 -0.9441 3186984 PK04_096252 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M21 compound treatment 1.61676358E8 1.11E7 0.29 1.78351151E8 7580000.0 0.21 0.357 0.9884 3068372 PK04_096253 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M22 compound treatment 9.1968306E7 -5.86E7 -1.53 9.1871888E7 -7.89E7 -2.22 -2.6565 -0.9836 3186721 PK04_096254 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M23 compound treatment 9.6177289E7 -5.44E7 -1.42 9.3537287E7 -7.72E7 -2.18 -2.5454 -0.9788 3068316 PK04_096255 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 M24 compound treatment 1.04183695E8 -4.64E7 -1.21 1.08262391E8 -6.25E7 -1.76 -2.1038 -0.9835 3068283 PK04_096256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N01 compound treatment 1.81892891E8 3.13E7 0.82 1.96822536E8 2.61E7 0.73 1.0993 0.9985 1694663 PK04_096257 Cc1c(NC(=O)CC#N)c(=O)n(c2ccccc2)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N02 compound treatment 1.59946344E8 9400000.0 0.25 1.76265629E8 5490000.0 0.15 0.2834 0.9751 3187226 PK04_096258 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C)C=C(CCCO)C=C1C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N03 compound treatment 1.40114207E8 -1.04E7 -0.27 1.51377801E8 -1.94E7 -0.55 -0.5796 -0.9486 3068949 PK04_096259 Cc1ccccc1/C=C/C=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N04 compound treatment 1.38328956E8 -1.22E7 -0.32 1.50297937E8 -2.05E7 -0.58 -0.6341 -0.9613 3187227 PK04_096260 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2ccc(CN3CCCC3)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N05 compound treatment 1.25926124E8 -2.46E7 -0.64 1.39477455E8 -3.13E7 -0.88 -1.0793 -0.9881 3068950 PK04_096261 CCOc1ccc(cc1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N06 compound treatment 1.24673007E8 -2.59E7 -0.68 1.35730207E8 -3.5E7 -0.99 -1.1772 -0.9831 3187228 PK04_096262 Oc1ccc2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N07 compound treatment 1.18779811E8 -3.18E7 -0.83 1.36229756E8 -3.45E7 -0.97 -1.2763 -0.9969 3068951 PK04_096263 [O-][N+](=O)c1cccc(c1)C2SCC(=O)N2c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N08 compound treatment 1.26903012E8 -2.36E7 -0.62 1.41361848E8 -2.94E7 -0.83 -1.0237 -0.9897 3187299 PK04_096264 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4cccs4)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N09 mock treatment 1.24749244E8 -2.58E7 -0.68 1.41105489E8 -2.97E7 -0.84 -1.0687 -0.9944 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N10 mock treatment 1.23518981E8 -2.7E7 -0.71 1.33468483E8 -3.73E7 -1.05 -1.2436 -0.9814 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N11 compound treatment 1.12759446E8 -3.78E7 -0.99 1.43805097E8 -2.7E7 -0.76 -1.2368 -0.9915 3068985 PK04_096265 Cc1cc(C)cc(c1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N12 compound treatment 1.42874141E8 -7670000.0 -0.2 1.60882559E8 -9890000.0 -0.28 -0.3391 -0.9871 3187300 PK04_096266 COc1cc2CCN(C)C(c3ccc(CN4CCCC4)cc3)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N13 mock treatment 1.11732746E8 -3.88E7 -1.02 1.30339093E8 -4.04E7 -1.14 -1.5241 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N14 mock treatment 1.21434093E8 -2.91E7 -0.76 1.32538592E8 -3.82E7 -1.08 -1.3007 -0.9856 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N15 compound treatment 1.0332509E8 -4.72E7 -1.24 1.22562013E8 -4.82E7 -1.36 -1.8347 -0.9989 3068986 PK04_096267 COc1ccc(/C=C/C=O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N16 compound treatment 1.33831856E8 -1.67E7 -0.44 1.60658234E8 -1.01E7 -0.28 -0.5109 -0.9784 3187301 PK04_096268 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N17 compound treatment 1.32005232E8 -1.85E7 -0.49 1.45846105E8 -2.49E7 -0.7 -0.8399 -0.9837 3068987 PK04_096269 Cc1cccc(/C=C/C=O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N18 compound treatment 1.34472044E8 -1.61E7 -0.42 1.56136664E8 -1.46E7 -0.41 -0.5892 -0.9999 3068988 PK04_096270 OCCCc1cc[n+](Cc2sc3ccccc3c2Cl)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N19 compound treatment 1.33749942E8 -1.68E7 -0.44 1.50636477E8 -2.01E7 -0.57 -0.7121 -0.9921 3068989 PK04_096271 Cc1ccc(/C=C/C=O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N20 compound treatment 6.5131839E7 -8.54E7 -2.24 8.543661E7 -8.53E7 -2.4 -3.2815 -0.9993 3187302 PK04_096272 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N21 compound treatment 1.21788192E8 -2.88E7 -0.75 1.3712695E8 -3.36E7 -0.95 -1.2028 -0.9935 3068990 PK04_096273 COc1cccc(/C=C/C=O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N22 compound treatment 1.57586739E8 7040000.0 0.18 1.72233362E8 1460000.0 0.04 0.1594 0.8444 3068991 PK04_096274 Oc1ccc2cc[n+](Cc3cc4OCOc4cc3Br)cc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N23 compound treatment 1.52536524E8 1990000.0 0.05 1.54688074E8 -1.61E7 -0.45 -0.2837 -0.6218 3187303 PK04_096275 Clc1ccccc1/C=C/C=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 N24 compound treatment 1.9912002E8 4.86E7 1.27 2.147079E8 4.39E7 1.24 1.7746 0.9999 3187304 PK04_096276 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)C5CC5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O01 compound treatment 1.88738847E8 3.82E7 1.0 2.03841554E8 3.31E7 0.93 1.3659 0.9994 3186631 PK04_096277 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O02 compound treatment 1.73981093E8 2.34E7 0.61 1.80845538E8 1.01E7 0.28 0.6345 0.9387 3067615 PK04_096278 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O03 compound treatment 8.3987644E7 -6.66E7 -1.74 8.7076662E7 -8.37E7 -2.36 -2.8998 -0.9889 3186715 PK04_096279 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O04 compound treatment 1.50293239E8 -255000.0 -0.01 1.66967043E8 -3800000.0 -0.11 -0.0805 -0.7497 3068363 PK04_096280 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O05 compound treatment 8.7534302E7 -6.3E7 -1.65 9.0684095E7 -8.01E7 -2.26 -2.7622 -0.9881 3068310 PK04_096281 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O06 compound treatment 1.39643364E8 -1.09E7 -0.29 1.55148449E8 -1.56E7 -0.44 -0.5131 -0.978 3068196 PK04_096282 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCN6CCOCC6)C4=O)c7ccccc7C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O07 compound treatment 7.6765528E7 -7.38E7 -1.93 8.9146495E7 -8.16E7 -2.3 -2.9922 -0.9962 3068277 PK04_096283 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O08 compound treatment 7.4115226E7 -7.64E7 -2.0 8.491994E7 -8.59E7 -2.42 -3.1255 -0.9955 3186720 PK04_096284 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O09 compound treatment 1.28073952E8 -2.25E7 -0.59 1.43287088E8 -2.75E7 -0.77 -0.9637 -0.9908 3186632 PK04_096285 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O10 compound treatment 1.24650374E8 -2.59E7 -0.68 1.44808112E8 -2.6E7 -0.73 -0.9967 -0.9993 3068157 PK04_096286 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(C5CCCCC5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O11 mock treatment 1.26583198E8 -2.4E7 -0.63 1.40426708E8 -3.03E7 -0.86 -1.0482 -0.9884 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O12 mock treatment 1.35264252E8 -1.53E7 -0.4 1.45757345E8 -2.5E7 -0.7 -0.7813 -0.964 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O13 compound treatment 1.31499858E8 -1.9E7 -0.5 1.43868546E8 -2.69E7 -0.76 -0.8887 -0.9793 3186874 PK04_096287 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O14 compound treatment 1.36892574E8 -1.37E7 -0.36 1.51717556E8 -1.91E7 -0.54 -0.6324 -0.9805 3068138 PK04_096288 COCCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O15 compound treatment 1.33573531E8 -1.7E7 -0.44 1.49175427E8 -2.16E7 -0.61 -0.7445 -0.9881 3186972 PK04_096289 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O16 compound treatment 1.35159879E8 -1.54E7 -0.4 1.57166475E8 -1.36E7 -0.38 -0.5559 -0.9997 3186981 PK04_096290 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O17 compound treatment 7.2627501E7 -7.79E7 -2.04 8.3102127E7 -8.77E7 -2.47 -3.1892 -0.9955 3186709 PK04_096291 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O18 compound treatment 8.1049396E7 -6.95E7 -1.82 8.8739985E7 -8.2E7 -2.31 -2.921 -0.993 3186725 PK04_096292 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O19 compound treatment 8.543439E7 -6.51E7 -1.7 8.7911634E7 -8.29E7 -2.34 -2.8563 -0.988 3068321 PK04_096293 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O20 compound treatment 1.46157561E8 -4390000.0 -0.11 1.63813753E8 -6960000.0 -0.2 -0.2199 -0.9676 3068192 PK04_096294 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O21 compound treatment 1.63885254E8 1.33E7 0.35 1.80101736E8 9330000.0 0.26 0.4328 0.9902 3068201 PK04_096295 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O22 compound treatment 1.60215988E8 9670000.0 0.25 1.74416995E8 3650000.0 0.1 0.2516 0.9212 3068381 PK04_096296 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O23 compound treatment 1.69680467E8 1.91E7 0.5 1.826094E8 1.18E7 0.33 0.59 0.9805 3186880 PK04_096297 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCc6ccccc6)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 O24 compound treatment 1.94497688E8 4.39E7 1.15 2.08829425E8 3.81E7 1.07 1.5719 0.9994 3186977 PK04_096298 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P01 compound treatment 2.04908378E8 5.44E7 1.42 2.11624237E8 4.09E7 1.15 1.8203 0.9945 3068992 PK04_096299 Cc1c(NC(=O)/C(=C/c2cccc(c2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P02 compound treatment 1.72977094E8 2.24E7 0.59 1.85013501E8 1.42E7 0.4 0.699 0.9828 3187305 PK04_096300 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)C2CC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P03 compound treatment 1.54372765E8 3820000.0 0.1 1.76030494E8 5260000.0 0.15 0.1756 0.9817 3187306 PK04_096301 COc1cccc(/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P04 compound treatment 1.7612566E8 2.56E7 0.67 1.89702109E8 1.89E7 0.53 0.8507 0.9937 3068993 PK04_096302 COc1cc2CC[N+](=Cc2cc1O)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P05 compound treatment 6.2457926E7 -8.81E7 -2.31 7.2499388E7 -9.83E7 -2.77 -3.5887 -0.9959 3068994 PK04_096303 Cc1c(NC(=O)/C(=C/c2ccccc2Cl)/C#N)c(=O)n(c3ccccc3)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P06 compound treatment 1.2193114E8 -2.86E7 -0.75 1.37691912E8 -3.31E7 -0.93 -1.1888 -0.9941 3187307 PK04_096304 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4cccs4)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P07 compound treatment 1.36518562E8 -1.4E7 -0.37 1.61682378E8 -9090000.0 -0.26 -0.4408 -0.9845 3187308 PK04_096305 Cc1c(NC(=O)/C(=C/c2ccc(Cl)cc2)/C#N)c(=O)n(c3ccccc3)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P08 compound treatment 1.39977346E8 -1.06E7 -0.28 1.55256341E8 -1.55E7 -0.44 -0.5048 -0.9757 3068995 PK04_096306 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3CCCO)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P09 compound treatment 1.24103707E8 -2.64E7 -0.69 1.512913E8 -1.95E7 -0.55 -0.8776 -0.9934 1972122 PK04_096307 Cc1cc(C)cc(c1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)CC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P10 compound treatment 1.41406674E8 -9140000.0 -0.24 1.57945204E8 -1.28E7 -0.36 -0.4248 -0.98 3187309 PK04_096308 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)C4CC4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P11 mock treatment 1.34367229E8 -1.62E7 -0.42 1.53871783E8 -1.69E7 -0.48 -0.6362 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P12 mock treatment 1.38458577E8 -1.21E7 -0.32 1.61183364E8 -9590000.0 -0.27 -0.4148 -0.9969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P13 compound treatment 9.6560764E7 -5.4E7 -1.41 1.20415291E8 -5.04E7 -1.42 -2.0027 -1.0 3068996 PK04_096309 Clc1ccc(/C=C/C=O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P14 compound treatment 1.2565877E8 -2.49E7 -0.65 1.59943891E8 -1.08E7 -0.31 -0.6764 -0.9402 3187310 PK04_096310 COc1cc2CC[N+](=Cc2cc1O)Cc3cccc(OC(F)(F)F)c3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P15 compound treatment 1.00546473E8 -5.0E7 -1.31 1.30664763E8 -4.01E7 -1.13 -1.7247 -0.9973 3068997 PK04_096311 O=C/C=C/c1ccc2OCOc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P16 compound treatment 1.29847206E8 -2.07E7 -0.54 1.68492272E8 -2280000.0 -0.06 -0.4286 -0.7854 3187311 PK04_096312 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3ccc(CN4CCCC4)cc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P17 compound treatment 4.9159764E7 -1.01E8 -2.65 6.3954786E7 -1.07E8 -3.01 -4.0052 -0.998 3068998 PK04_096313 O=C/C=C/c1ccc(cc1)c2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P18 compound treatment 8.7863352E7 -6.27E7 -1.64 1.23751657E8 -4.7E7 -1.33 -2.0972 -0.9944 3187312 PK04_096314 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P19 compound treatment 6.4544511E7 -8.6E7 -2.25 7.6103749E7 -9.47E7 -2.67 -3.4783 -0.9964 3187313 PK04_096315 O=C/C=C/c1ccc(\C=C\c2ccccc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P20 compound treatment 1.65645399E8 1.51E7 0.4 1.83460045E8 1.27E7 0.36 0.5323 0.9988 3187314 PK04_096316 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4cccs4)c2cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P21 compound treatment 1.54251748E8 3700000.0 0.1 1.8676104E8 1.6E7 0.45 0.3872 0.84 3069028 PK04_096317 [O-][N+](=O)c1cccc(c1)C2N(C(=O)CS2(=O)=O)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P22 compound treatment 1.57183743E8 6640000.0 0.17 1.87783142E8 1.7E7 0.48 0.4618 0.9057 3187315 PK04_096318 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P23 compound treatment 1.09623747E8 -4.09E7 -1.07 1.16782883E8 -5.4E7 -1.52 -1.8333 -0.9853 3069029 PK04_096319 CCOc1ccc(cc1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2096 P24 compound treatment 2.02410254E8 5.19E7 1.36 2.18351647E8 4.76E7 1.34 1.9081 1.0 3187316 PK04_096320 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)C3CC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A01 compound treatment 2.14664649E8 6.23E7 1.63 2.14804676E8 4.87E7 1.37 2.1231 0.9964 2141518 PK04_097001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A02 compound treatment 1.60562247E8 8160000.0 0.21 1.73030427E8 6940000.0 0.2 0.2893 0.999 2141905 PK04_097002 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A03 compound treatment 1.19571255E8 -3.28E7 -0.86 1.2675839E8 -3.93E7 -1.11 -1.3915 -0.9921 2141091 PK04_097003 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A04 compound treatment 1.9006007E8 3.77E7 0.99 1.96242799E8 3.01E7 0.85 1.2978 0.9973 2141692 PK04_097004 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A05 compound treatment 1.65160403E8 1.28E7 0.33 1.74458362E8 8360000.0 0.24 0.4028 0.9854 2141533 PK04_097005 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A06 compound treatment 7.1981229E7 -8.04E7 -2.11 7.6224624E7 -8.99E7 -2.53 -3.2794 -0.9958 2141714 PK04_097006 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A07 compound treatment 1.59794879E8 7390000.0 0.19 1.7016243E8 4070000.0 0.11 0.2179 0.9688 2141463 PK04_097007 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A08 compound treatment 1.63368019E8 1.1E7 0.29 1.63827469E8 -2270000.0 -0.06 0.1578 0.5366 2141076 PK04_097008 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A09 compound treatment 1.50667344E8 -1730000.0 -0.05 1.59535604E8 -6560000.0 -0.18 -0.1628 -0.8554 2141109 PK04_097009 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A10 compound treatment 8.0623341E7 -7.18E7 -1.88 9.6885588E7 -6.92E7 -1.95 -2.7077 -0.9998 2141546 PK04_097010 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A11 compound treatment 1.4632615E8 -6080000.0 -0.16 1.51222652E8 -1.49E7 -0.42 -0.4088 -0.912 2141079 PK04_097011 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A12 compound treatment 1.48369752E8 -4030000.0 -0.11 1.57348003E8 -8750000.0 -0.25 -0.2489 -0.9284 2141141 PK04_097012 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A13 mock treatment 1.63848792E8 1.14E7 0.3 1.68834766E8 2740000.0 0.08 0.2665 0.8612 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A14 mock treatment 1.44774547E8 -7630000.0 -0.2 1.46395128E8 -1.97E7 -0.56 -0.5337 -0.9047 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A15 compound treatment 6.5361763E7 -8.7E7 -2.28 6.7596543E7 -9.85E7 -2.78 -3.5738 -0.9952 2141882 PK04_097013 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A16 compound treatment 1.73612081E8 2.12E7 0.56 1.74849372E8 8760000.0 0.25 0.5671 0.9333 2141936 PK04_097014 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A17 compound treatment 1.12486988E8 -3.99E7 -1.04 1.13339703E8 -5.28E7 -1.49 -1.79 -0.9851 2141372 PK04_097015 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A18 compound treatment 1.85419701E8 3.3E7 0.86 1.89059953E8 2.3E7 0.65 1.0688 0.9898 2141092 PK04_097016 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A19 compound treatment 1.84235818E8 3.18E7 0.83 1.88562321E8 2.25E7 0.63 1.037 0.9908 2141344 PK04_097017 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A20 compound treatment 1.76703484E8 2.43E7 0.64 1.80380914E8 1.43E7 0.4 0.7345 0.9756 2141115 PK04_097018 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A21 compound treatment 1.66496187E8 1.41E7 0.37 1.77212871E8 1.11E7 0.31 0.4824 0.9967 2141570 PK04_097019 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A22 compound treatment 1.63178376E8 1.08E7 0.28 1.70024551E8 3930000.0 0.11 0.2778 0.9166 2141549 PK04_097020 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A23 compound treatment 1.55735921E8 3330000.0 0.09 1.65137731E8 -957000.0 -0.03 0.0427 0.467 2141876 PK04_097021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 A24 compound treatment 1.56245791E8 3840000.0 0.1 1.7681812E8 1.07E7 0.3 0.2848 0.8943 2141753 PK04_097022 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B01 compound treatment 1.81174219E8 2.88E7 0.75 1.87200804E8 2.11E7 0.59 0.9532 0.9932 2141940 PK04_097023 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B02 compound treatment 9.9330694E7 -5.31E7 -1.39 9.2969283E7 -7.31E7 -2.06 -2.4395 -0.9816 2142685 PK04_097024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B03 compound treatment 1.50482076E8 -1920000.0 -0.05 1.53933357E8 -1.22E7 -0.34 -0.2779 -0.8022 2141335 PK04_097025 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B04 compound treatment 1.45767046E8 -6630000.0 -0.17 1.53184458E8 -1.29E7 -0.36 -0.3801 -0.9427 2143933 PK04_097026 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B05 compound treatment 1.45837194E8 -6560000.0 -0.17 1.62168772E8 -3930000.0 -0.11 -0.1997 -0.9773 2141445 PK04_097027 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B06 compound treatment 1.06539656E8 -4.59E7 -1.2 1.19109029E8 -4.7E7 -1.32 -1.7851 -0.9988 2144925 PK04_097028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B07 compound treatment 5.5444844E7 -9.7E7 -2.54 7.3267128E7 -9.28E7 -2.62 -3.6444 -0.9999 2141881 PK04_097029 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B08 compound treatment 1.18423579E8 -3.4E7 -0.89 1.3570688E8 -3.04E7 -0.86 -1.2344 -0.9998 2144289 PK04_097030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B09 compound treatment 8.5467664E7 -6.69E7 -1.75 1.03787351E8 -6.23E7 -1.76 -2.4805 -1.0 2141150 PK04_097031 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B10 compound treatment 8.4325544E7 -6.81E7 -1.78 9.7187854E7 -6.89E7 -1.94 -2.6331 -0.9991 2144633 PK04_097032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B11 compound treatment 1.15046242E8 -3.74E7 -0.98 1.2055372E8 -4.55E7 -1.28 -1.5989 -0.991 2141161 PK04_097033 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B12 compound treatment 1.0630182E8 -4.61E7 -1.21 1.16570194E8 -4.95E7 -1.4 -1.8401 -0.9974 2144765 PK04_097034 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B13 mock treatment 1.24828064E8 -2.76E7 -0.72 1.36645806E8 -2.94E7 -0.83 -1.0972 -0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B14 mock treatment 1.21441563E8 -3.1E7 -0.81 1.33754424E8 -3.23E7 -0.91 -1.2175 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B15 compound treatment 1.47182874E8 -5220000.0 -0.14 1.47489426E8 -1.86E7 -0.52 -0.4673 -0.8625 2141135 PK04_097035 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B16 compound treatment 1.10684127E8 -4.17E7 -1.09 1.21338867E8 -4.48E7 -1.26 -1.664 -0.9974 2144753 PK04_097036 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B17 compound treatment 1.28437422E8 -2.4E7 -0.63 1.40104401E8 -2.6E7 -0.73 -0.9615 -0.997 2141225 PK04_097037 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B18 compound treatment 4.8327132E7 -1.04E8 -2.72 5.609164E7 -1.1E8 -3.1 -4.1184 -0.9979 2144045 PK04_097038 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B19 compound treatment 1.31558751E8 -2.08E7 -0.55 1.41262326E8 -2.48E7 -0.7 -0.8806 -0.9924 2141420 PK04_097039 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B20 compound treatment 1.61030003E8 8630000.0 0.23 1.69018506E8 2920000.0 0.08 0.218 0.9066 2144377 PK04_097040 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B21 compound treatment 1.71838434E8 1.94E7 0.51 1.89542465E8 2.34E7 0.66 0.827 0.9917 2141808 PK04_097041 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B22 compound treatment 1.69872818E8 1.75E7 0.46 1.85130556E8 1.9E7 0.54 0.7027 0.9968 2143265 PK04_097042 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B23 compound treatment 1.73631986E8 2.12E7 0.56 1.84371995E8 1.83E7 0.52 0.7572 0.9993 2141931 PK04_097043 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 B24 compound treatment 1.71224908E8 1.88E7 0.49 1.85574171E8 1.95E7 0.55 0.7366 0.9985 2142705 PK04_097044 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C01 compound treatment 1.64851311E8 1.24E7 0.33 1.77814492E8 1.17E7 0.33 0.464 1.0 2141223 PK04_097045 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C02 compound treatment 1.55996825E8 3600000.0 0.09 1.62928936E8 -3170000.0 -0.09 0.0035 0.0268 2141108 PK04_097046 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C03 compound treatment 6.4699174E7 -8.77E7 -2.3 6.8146875E7 -9.79E7 -2.76 -3.5751 -0.9958 2141329 PK04_097047 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C04 compound treatment 1.33214179E8 -1.92E7 -0.5 1.39221964E8 -2.69E7 -0.76 -0.8906 -0.9801 2141703 PK04_097048 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C05 compound treatment 1.41378447E8 -1.1E7 -0.29 1.67032031E8 938000.0 0.03 -0.1853 -0.6397 2065845 PK04_097049 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C06 compound treatment 1.31435259E8 -2.1E7 -0.55 1.46553552E8 -1.95E7 -0.55 -0.7775 -1.0 2141782 PK04_097050 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C07 compound treatment 1.16412124E8 -3.6E7 -0.94 1.40222637E8 -2.59E7 -0.73 -1.1817 -0.992 2141574 PK04_097051 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C08 compound treatment 1.06506555E8 -4.59E7 -1.2 1.2984093E8 -3.63E7 -1.02 -1.5719 -0.9967 2141856 PK04_097052 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C09 compound treatment 8.1378065E7 -7.1E7 -1.86 9.1621742E7 -7.45E7 -2.1 -2.7986 -0.9982 2141751 PK04_097053 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C10 compound treatment 1.11198508E8 -4.12E7 -1.08 1.26680425E8 -3.94E7 -1.11 -1.548 -0.9999 2141441 PK04_097054 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C11 mock treatment 1.23985282E8 -2.84E7 -0.74 1.40373809E8 -2.57E7 -0.72 -1.0385 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C12 mock treatment 1.10853176E8 -4.15E7 -1.09 1.35489819E8 -3.06E7 -0.86 -1.3789 -0.9934 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C13 compound treatment 1.16381458E8 -3.6E7 -0.94 1.33095368E8 -3.3E7 -0.93 -1.3243 -1.0 2141937 PK04_097055 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C14 compound treatment 3.5526043E7 -1.17E8 -3.06 4.6515783E7 -1.2E8 -3.37 -4.5461 -0.9988 2141727 PK04_097056 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C15 mock treatment 1.21774881E8 -3.06E7 -0.8 1.45026702E8 -2.11E7 -0.59 -0.9867 -0.9891 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C16 mock treatment 1.27879924E8 -2.45E7 -0.64 1.46426447E8 -1.97E7 -0.55 -0.8458 -0.9973 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C17 compound treatment 1.66472143E8 1.41E7 0.37 1.73925423E8 7830000.0 0.22 0.4165 0.97 2141078 PK04_097057 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C18 compound treatment 1.37032992E8 -1.54E7 -0.4 1.54651594E8 -1.14E7 -0.32 -0.5125 -0.994 2141467 PK04_097058 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C19 compound treatment 1.52792497E8 391000.0 0.01 1.66531E8 437000.0 0.01 0.0159 0.9958 2141339 PK04_097059 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C20 compound treatment 2.7856677E7 -1.25E8 -3.26 2.9845675E7 -1.36E8 -3.84 -5.0203 -0.9967 2141364 PK04_097060 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C21 compound treatment 8.7734373E7 -6.47E7 -1.69 1.0298249E8 -6.31E7 -1.78 -2.4546 -0.9997 2141370 PK04_097061 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C22 compound treatment 1.46782138E8 -5620000.0 -0.15 1.57248143E8 -8850000.0 -0.25 -0.2803 -0.9683 2141489 PK04_097062 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C23 compound treatment 1.35844165E8 -1.66E7 -0.43 1.45115783E8 -2.1E7 -0.59 -0.7245 -0.9884 2141706 PK04_097063 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 C24 compound treatment 1.93348416E8 4.09E7 1.07 2.11884558E8 4.58E7 1.29 1.6704 0.9957 2141172 PK04_097064 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D01 compound treatment 1.81978962E8 2.96E7 0.77 2.00147949E8 3.41E7 0.96 1.226 0.9943 2141788 PK04_097065 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D02 compound treatment 1.29801735E8 -2.26E7 -0.59 1.44795307E8 -2.13E7 -0.6 -0.8427 -1.0 2143973 PK04_097066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D03 compound treatment 1.46575333E8 -5830000.0 -0.15 1.66579055E8 485000.0 0.01 -0.0982 -0.6412 2141854 PK04_097067 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D04 compound treatment 1.04793E8 -4.76E7 -1.25 1.11329507E8 -5.48E7 -1.54 -1.9725 -0.9944 2141969 PK04_097068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D05 compound treatment 1.4222857E8 -1.02E7 -0.27 1.69373307E8 3280000.0 0.09 -0.123 -0.4362 2141087 PK04_097069 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D06 compound treatment 1.0322988E8 -4.92E7 -1.29 1.10902159E8 -5.52E7 -1.56 -2.0099 -0.9956 2144657 PK04_097070 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D07 compound treatment 1.31748645E8 -2.07E7 -0.54 1.54241567E8 -1.19E7 -0.33 -0.6185 -0.9732 2141768 PK04_097071 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D08 compound treatment 7.486277E7 -7.75E7 -2.03 8.2687629E7 -8.34E7 -2.35 -3.0972 -0.9973 2144733 PK04_097072 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D09 compound treatment 9.4988702E7 -5.74E7 -1.5 1.1725336E8 -4.88E7 -1.38 -2.0359 -0.999 2141552 PK04_097073 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D10 compound treatment 5.0874805E7 -1.02E8 -2.66 5.6255292E7 -1.1E8 -3.1 -4.068 -0.9971 2143885 PK04_097074 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D11 mock treatment 1.1872559E8 -3.37E7 -0.88 1.35848181E8 -3.02E7 -0.85 -1.226 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D12 mock treatment 1.32996781E8 -1.94E7 -0.51 1.40558767E8 -2.55E7 -0.72 -0.868 -0.9855 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D13 compound treatment 1.35872925E8 -1.65E7 -0.43 1.51825641E8 -1.43E7 -0.4 -0.5903 -0.9993 2141513 PK04_097075 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D14 compound treatment 1.26864412E8 -2.55E7 -0.67 1.4100986E8 -2.51E7 -0.71 -0.9725 -0.9996 2144449 PK04_097076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D15 mock treatment 1.34504417E8 -1.79E7 -0.47 1.51958038E8 -1.41E7 -0.4 -0.613 -0.9967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D16 mock treatment 1.57913508E8 5510000.0 0.14 1.68092983E8 2000000.0 0.06 0.1419 0.9158 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D17 compound treatment 1.37915136E8 -1.45E7 -0.38 1.57405383E8 -8690000.0 -0.24 -0.4413 -0.9776 2141816 PK04_097077 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D18 compound treatment 1.27331411E8 -2.51E7 -0.66 1.46998012E8 -1.91E7 -0.54 -0.8446 -0.9951 2142085 PK04_097078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D19 compound treatment 1.52845644E8 444000.0 0.01 1.71793417E8 5700000.0 0.16 0.1218 0.7563 2141432 PK04_097079 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D20 compound treatment 1.32931028E8 -1.95E7 -0.51 1.48099156E8 -1.8E7 -0.51 -0.719 -1.0 2144825 PK04_097080 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D21 compound treatment 1.49110179E8 -3290000.0 -0.09 1.69000152E8 2910000.0 0.08 -0.003 -0.0254 2141123 PK04_097081 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D22 compound treatment 8.7767195E7 -6.46E7 -1.69 1.07952521E8 -5.81E7 -1.64 -2.3549 -0.9999 2144893 PK04_097082 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D23 compound treatment 1.45282402E8 -7120000.0 -0.19 1.57553235E8 -8540000.0 -0.24 -0.302 -0.992 2141421 PK04_097083 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 D24 compound treatment 2.18372484E8 6.6E7 1.73 2.18545713E8 5.25E7 1.48 2.2663 0.997 2143085 PK04_097084 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E01 mock treatment 1.80560463E8 2.82E7 0.74 1.98989313E8 3.29E7 0.93 1.1767 0.9936 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E02 mock treatment 1.5145149E8 -950000.0 -0.02 1.75112117E8 9020000.0 0.25 0.1621 0.6349 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E03 compound treatment 1.06065266E8 -4.63E7 -1.21 1.10992852E8 -5.51E7 -1.55 -1.9557 -0.9925 2141878 PK04_097085 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E04 compound treatment 1.58456637E8 6060000.0 0.16 1.78493988E8 1.24E7 0.35 0.3592 0.9361 2141520 PK04_097086 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E05 compound treatment 8.2458232E7 -6.99E7 -1.83 9.5359472E7 -7.07E7 -1.99 -2.7041 -0.9991 2141359 PK04_097087 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E06 compound treatment 6.4425037E7 -8.8E7 -2.3 7.1334676E7 -9.48E7 -2.67 -3.5167 -0.9973 2141507 PK04_097088 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E07 compound treatment 1.35907417E8 -1.65E7 -0.43 1.53570436E8 -1.25E7 -0.35 -0.5549 -0.995 2141863 PK04_097089 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E08 compound treatment 1.45629466E8 -6770000.0 -0.18 1.5804305E8 -8050000.0 -0.23 -0.2858 -0.9925 2141163 PK04_097090 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E09 mock treatment 1.30202285E8 -2.22E7 -0.58 1.51005669E8 -1.51E7 -0.43 -0.7116 -0.9882 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E10 mock treatment 1.24485476E8 -2.79E7 -0.73 1.43795122E8 -2.23E7 -0.63 -0.9611 -0.9972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E11 compound treatment 1.23230743E8 -2.92E7 -0.76 1.43867016E8 -2.22E7 -0.63 -0.9829 -0.9952 2141456 PK04_097091 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E12 compound treatment 3.3332922E7 -1.19E8 -3.12 3.5968081E7 -1.3E8 -3.67 -4.7969 -0.9967 2141683 PK04_097092 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E13 compound treatment 1.24881195E8 -2.75E7 -0.72 1.40553989E8 -2.55E7 -0.72 -1.0183 -1.0 2141357 PK04_097093 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E14 compound treatment 1.05286987E8 -4.71E7 -1.23 1.1669434E8 -4.94E7 -1.39 -1.8565 -0.9982 2141366 PK04_097094 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E15 compound treatment 1.21984912E8 -3.04E7 -0.8 1.37132711E8 -2.9E7 -0.82 -1.1401 -0.9999 2141575 PK04_097095 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E16 compound treatment 1.29736298E8 -2.27E7 -0.59 1.38599438E8 -2.75E7 -0.77 -0.9674 -0.9913 2141485 PK04_097096 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E17 mock treatment 1.54935642E8 2530000.0 0.07 1.67146317E8 1050000.0 0.03 0.0679 0.9341 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E18 mock treatment 1.70496473E8 1.81E7 0.47 1.7496211E8 8870000.0 0.25 0.5116 0.9554 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E19 compound treatment 1.02707941E8 -4.97E7 -1.3 1.09182265E8 -5.69E7 -1.6 -2.0539 -0.9946 2141377 PK04_097097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E20 compound treatment 7.6422251E7 -7.6E7 -1.99 8.0277607E7 -8.58E7 -2.42 -3.1164 -0.9953 2141326 PK04_097098 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E21 compound treatment 8.255079E7 -6.99E7 -1.83 7.9047697E7 -8.7E7 -2.45 -3.0275 -0.9895 2141702 PK04_097099 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E22 compound treatment 1.13301727E8 -3.91E7 -1.02 1.19966755E8 -4.61E7 -1.3 -1.6429 -0.993 2141417 PK04_097100 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E23 compound treatment 1.75707161E8 2.33E7 0.61 1.91553588E8 2.55E7 0.72 0.9387 0.9967 2141167 PK04_097101 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 E24 compound treatment 1.31257744E8 -2.11E7 -0.55 1.4738323E8 -1.87E7 -0.53 -0.7642 -0.9997 2141113 PK04_097102 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F01 mock treatment 1.75246336E8 2.28E7 0.6 4.0160494E7 -1.26E8 -3.55 -2.0866 -0.5798 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F02 mock treatment 1.80173401E8 2.78E7 0.73 1.87150761E8 2.11E7 0.59 0.9336 0.9949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F03 compound treatment 6.8809029E7 -8.36E7 -2.19 7.7046685E7 -8.9E7 -2.51 -3.3217 -0.9977 2141216 PK04_097103 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F04 compound treatment 1.34686037E8 -1.77E7 -0.46 1.57536959E8 -8560000.0 -0.24 -0.4984 -0.9536 2142933 PK04_097104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F05 compound treatment 8.380837E7 -6.86E7 -1.8 9.3176816E7 -7.29E7 -2.05 -2.7226 -0.9977 2141355 PK04_097105 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F06 compound treatment 1.20036882E8 -3.24E7 -0.85 1.33260554E8 -3.28E7 -0.93 -1.2533 -0.999 2142833 PK04_097106 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F07 compound treatment 1.15865865E8 -3.65E7 -0.96 1.32865162E8 -3.32E7 -0.94 -1.3384 -0.9999 2141414 PK04_097107 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F08 compound treatment 1.31922979E8 -2.05E7 -0.54 1.57721231E8 -8370000.0 -0.24 -0.5459 -0.9321 2144249 PK04_097108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F09 mock treatment 1.39955605E8 -1.24E7 -0.33 1.52966694E8 -1.31E7 -0.37 -0.492 -0.998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F10 mock treatment 1.22856742E8 -2.95E7 -0.77 1.45030853E8 -2.11E7 -0.59 -0.9666 -0.9915 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F11 compound treatment 7.0957849E7 -8.14E7 -2.13 7.9024035E7 -8.71E7 -2.45 -3.2425 -0.9975 2141568 PK04_097109 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F12 compound treatment 2.6641593E7 -1.26E8 -3.29 2.9451424E7 -1.37E8 -3.85 -5.0506 -0.997 2142765 PK04_097110 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F13 compound treatment 1.09914546E8 -4.25E7 -1.11 1.25410115E8 -4.07E7 -1.15 -1.5971 -0.9999 2141348 PK04_097111 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F14 compound treatment 1.46210827E8 -6190000.0 -0.16 1.58268273E8 -7830000.0 -0.22 -0.2705 -0.9885 2142645 PK04_097112 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F15 compound treatment 1.00315553E8 -5.21E7 -1.36 1.09756386E8 -5.63E7 -1.59 -2.0867 -0.9971 2141505 PK04_097113 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F16 compound treatment 1.48365408E8 -4040000.0 -0.11 1.5668979E8 -9400000.0 -0.27 -0.2621 -0.9187 2142977 PK04_097114 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F17 mock treatment 1.59452648E8 7050000.0 0.18 1.66447983E8 354000.0 0.01 0.1376 0.7442 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F18 mock treatment 1.64756763E8 1.24E7 0.32 1.80273632E8 1.42E7 0.4 0.5112 0.9945 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F19 compound treatment 1.4513352E8 -7270000.0 -0.19 1.52990641E8 -1.31E7 -0.37 -0.3956 -0.9524 2141200 PK04_097115 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F20 compound treatment 1.50680416E8 -1720000.0 -0.05 1.59245084E8 -6850000.0 -0.19 -0.1683 -0.8493 2142045 PK04_097116 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F21 compound treatment 1.46191561E8 -6210000.0 -0.16 1.53318539E8 -1.28E7 -0.36 -0.3695 -0.9354 2141938 PK04_097117 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F22 compound treatment 1.54077916E8 1680000.0 0.04 1.62671159E8 -3420000.0 -0.1 -0.0372 -0.3508 2144373 PK04_097118 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F23 compound treatment 1.25435252E8 -2.7E7 -0.71 1.40355678E8 -2.57E7 -0.73 -1.012 -0.9999 2141419 PK04_097119 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 F24 compound treatment 1.42105631E8 -1.03E7 -0.27 1.40631793E8 -2.55E7 -0.72 -0.698 -0.9106 2142769 PK04_097120 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G01 compound treatment 1.51393717E8 -1010000.0 -0.03 1.55160167E8 -1.09E7 -0.31 -0.2365 -0.7648 2141178 PK04_097121 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G02 compound treatment 1.20059872E8 -3.23E7 -0.85 1.39271763E8 -2.68E7 -0.76 -1.1331 -0.9984 2141487 PK04_097122 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G03 mock treatment 1.63072823E8 1.07E7 0.28 1.86321379E8 2.02E7 0.57 0.6006 0.9461 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G04 mock treatment 1.51757944E8 -644000.0 -0.02 1.78060414E8 1.2E7 0.34 0.2265 0.6709 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G05 compound treatment 1.56140796E8 3740000.0 0.1 1.76056367E8 9960000.0 0.28 0.2677 0.9005 2141519 PK04_097123 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G06 compound treatment 1.52586692E8 185000.0 0.0 1.68716806E8 2620000.0 0.07 0.0557 0.7519 2141537 PK04_097124 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G07 compound treatment 3.9425738E7 -1.13E8 -2.96 4.5320742E7 -1.21E8 -3.4 -4.4978 -0.9975 2141722 PK04_097125 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G08 compound treatment 1.41168321E8 -1.12E7 -0.29 1.56899917E8 -9190000.0 -0.26 -0.3911 -0.998 2141577 PK04_097126 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G09 compound treatment 1.36686293E8 -1.57E7 -0.41 1.51483101E8 -1.46E7 -0.41 -0.582 -1.0 2141458 PK04_097127 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G10 compound treatment 1.39923745E8 -1.25E7 -0.33 1.52190092E8 -1.39E7 -0.39 -0.508 -0.9959 2141190 PK04_097128 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G11 compound treatment 1.14359791E8 -3.8E7 -1.0 1.30443722E8 -3.57E7 -1.0 -1.4145 -1.0 2141333 PK04_097129 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G12 compound treatment 1.20187497E8 -3.22E7 -0.84 1.34729426E8 -3.14E7 -0.88 -1.2213 -0.9997 2141508 PK04_097130 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G13 compound treatment 1.42032704E8 -1.04E7 -0.27 1.53093993E8 -1.3E7 -0.37 -0.451 -0.9891 2141118 PK04_097131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G14 compound treatment 6.4079746E7 -8.83E7 -2.31 7.222631E7 -9.39E7 -2.65 -3.5053 -0.9977 2141927 PK04_097132 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G15 compound treatment 1.45843873E8 -6560000.0 -0.17 1.55622966E8 -1.05E7 -0.3 -0.33 -0.9668 2141159 PK04_097133 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G16 compound treatment 1.30556617E8 -2.18E7 -0.57 1.42444823E8 -2.36E7 -0.67 -0.8756 -0.9971 2141713 PK04_097134 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G17 compound treatment 1.63575353E8 1.12E7 0.29 1.71059903E8 4970000.0 0.14 0.3058 0.943 2141795 PK04_097135 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G18 compound treatment 1.50960246E8 -1440000.0 -0.04 1.57673058E8 -8420000.0 -0.24 -0.1945 -0.8094 2141553 PK04_097136 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G19 mock treatment 1.75595398E8 2.32E7 0.61 1.83076503E8 1.7E7 0.48 0.7677 0.9931 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G20 mock treatment 1.77159262E8 2.48E7 0.65 1.86037328E8 1.99E7 0.56 0.8557 0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G21 compound treatment 1.49373557E8 -3030000.0 -0.08 1.61409415E8 -4680000.0 -0.13 -0.1494 -0.9702 2141819 PK04_097137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G22 compound treatment 1.90852757E8 3.85E7 1.01 2.01686713E8 3.56E7 1.0 1.421 1.0 2141516 PK04_097138 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G23 compound treatment 1.86436946E8 3.4E7 0.89 1.94847858E8 2.88E7 0.81 1.2029 0.9989 2141691 PK04_097139 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 G24 compound treatment 5.1643716E7 -1.01E8 -2.64 5.6505636E7 -1.1E8 -3.09 -4.0487 -0.9969 2141155 PK04_097140 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H01 compound treatment 1.66679402E8 1.43E7 0.37 1.88942873E8 2.28E7 0.64 0.7196 0.9665 2141157 PK04_097141 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H02 compound treatment 1.38666779E8 -1.37E7 -0.36 1.7952062E8 1.34E7 0.38 0.0133 0.0255 2143037 PK04_097142 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H03 mock treatment 1.64082546E8 1.17E7 0.31 1.81842889E8 1.57E7 0.44 0.53 0.9835 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H04 mock treatment 1.54448579E8 2050000.0 0.05 1.76025939E8 9930000.0 0.28 0.2358 0.8275 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H05 compound treatment 5.9719392E7 -9.27E7 -2.43 6.3397886E7 -1.03E8 -2.89 -3.7619 -0.9962 2141926 PK04_097143 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H06 compound treatment 1.42390754E8 -1.0E7 -0.26 1.6135578E8 -4740000.0 -0.13 -0.2797 -0.9511 2143177 PK04_097144 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H07 compound treatment 1.49826534E8 -2570000.0 -0.07 1.66631527E8 537000.0 0.02 -0.037 -0.535 2141694 PK04_097145 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H08 compound treatment 1.46503419E8 -5900000.0 -0.15 1.61647706E8 -4450000.0 -0.13 -0.1978 -0.9946 2143025 PK04_097146 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H09 compound treatment 2.7418517E7 -1.25E8 -3.27 3.1907759E7 -1.34E8 -3.78 -4.9873 -0.9974 2141749 PK04_097147 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H10 compound treatment 1.22721715E8 -2.97E7 -0.78 1.43959213E8 -2.21E7 -0.62 -0.9904 -0.9941 2143077 PK04_097148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H11 compound treatment 9.0587202E7 -6.18E7 -1.62 1.09057675E8 -5.7E7 -1.61 -2.2807 -1.0 2141097 PK04_097149 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H12 compound treatment 1.35160007E8 -1.72E7 -0.45 1.52266019E8 -1.38E7 -0.39 -0.5947 -0.9973 2142913 PK04_097150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H13 compound treatment 1.07628259E8 -4.48E7 -1.17 1.24379766E8 -4.17E7 -1.18 -1.66 -1.0 2141401 PK04_097151 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H14 compound treatment 1.40800013E8 -1.16E7 -0.3 1.54862668E8 -1.12E7 -0.32 -0.4385 -0.9998 2143093 PK04_097152 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H15 compound treatment 1.57021513E8 4620000.0 0.12 1.65340508E8 -754000.0 -0.02 0.0705 0.5741 2141777 PK04_097153 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H16 compound treatment 1.19941797E8 -3.25E7 -0.85 1.31321544E8 -3.48E7 -0.98 -1.2937 -0.9975 2143865 PK04_097154 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H17 compound treatment 1.6784263E8 1.54E7 0.4 1.7770395E8 1.16E7 0.33 0.5172 0.9945 2141142 PK04_097155 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H18 compound treatment 1.68674397E8 1.63E7 0.43 1.76375463E8 1.03E7 0.29 0.5061 0.9824 2143925 PK04_097156 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H19 mock treatment 1.72509664E8 2.01E7 0.53 1.83051212E8 1.7E7 0.48 0.7101 0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H20 mock treatment 1.70412431E8 1.8E7 0.47 1.82602651E8 1.65E7 0.47 0.6623 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H21 compound treatment 1.83066297E8 3.07E7 0.8 1.92197268E8 2.61E7 0.74 1.0877 0.999 2141168 PK04_097157 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H22 compound treatment 1.82679819E8 3.03E7 0.79 1.935918E8 2.75E7 0.77 1.1084 0.9999 2143057 PK04_097158 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H23 compound treatment 1.91993038E8 3.96E7 1.04 2.09274798E8 4.32E7 1.22 1.5933 0.9968 2141804 PK04_097159 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 H24 compound treatment 1.97510211E8 4.51E7 1.18 2.07628381E8 4.15E7 1.17 1.6626 1.0 2142649 PK04_097160 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I01 compound treatment 1.69640803E8 1.72E7 0.45 1.82657383E8 1.66E7 0.47 0.6491 0.9999 2141890 PK04_097161 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I02 compound treatment 1.42068528E8 -1.03E7 -0.27 1.79979695E8 1.39E7 0.39 0.0854 0.1796 2141465 PK04_097162 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I03 compound treatment 1.42588254E8 -9810000.0 -0.26 1.70821684E8 4730000.0 0.13 -0.0874 -0.3022 2141772 PK04_097163 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I04 compound treatment 1.57603217E8 5200000.0 0.14 1.79647798E8 1.36E7 0.38 0.3664 0.9035 2141343 PK04_097164 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I05 mock treatment 1.58115432E8 5710000.0 0.15 1.71530226E8 5440000.0 0.15 0.2141 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I06 mock treatment 1.44756507E8 -7640000.0 -0.2 1.67024601E8 930000.0 0.03 -0.123 -0.6093 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I07 compound treatment 1.4655199E8 -5850000.0 -0.15 1.67234717E8 1140000.0 0.03 -0.0855 -0.5468 2141794 PK04_097165 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I08 compound treatment 6.5488286E7 -8.69E7 -2.28 7.7456136E7 -8.86E7 -2.5 -3.375 -0.9989 2141922 PK04_097166 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I09 compound treatment 1.43623969E8 -8780000.0 -0.23 1.61745237E8 -4350000.0 -0.12 -0.2491 -0.9567 2141780 PK04_097167 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I10 compound treatment 1.36681489E8 -1.57E7 -0.41 1.52057087E8 -1.4E7 -0.4 -0.5707 -0.9998 2141799 PK04_097168 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I11 compound treatment 1.34904989E8 -1.75E7 -0.46 1.5687585E8 -9220000.0 -0.26 -0.5075 -0.9639 2141177 PK04_097169 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I12 compound treatment 4.2635107E7 -1.1E8 -2.87 5.7135473E7 -1.09E8 -3.07 -4.2029 -0.9995 2141747 PK04_097170 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I13 compound treatment 1.23860384E8 -2.85E7 -0.75 1.43892347E8 -2.22E7 -0.63 -0.9707 -0.9961 2141423 PK04_097171 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I14 compound treatment 1.47524849E8 -4880000.0 -0.13 1.63136251E8 -2960000.0 -0.08 -0.1492 -0.9787 2141775 PK04_097172 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I15 compound treatment 1.47222556E8 -5180000.0 -0.14 1.62358573E8 -3740000.0 -0.11 -0.1703 -0.9922 2141538 PK04_097173 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I16 compound treatment 1.56550347E8 4150000.0 0.11 1.64137395E8 -1960000.0 -0.06 0.0378 0.3103 2065871 PK04_097174 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I17 compound treatment 9.0184971E7 -6.22E7 -1.63 9.6276227E7 -6.98E7 -1.97 -2.5428 -0.9956 2141729 PK04_097175 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I18 compound treatment 1.62839537E8 1.04E7 0.27 1.71956751E8 5860000.0 0.17 0.31 0.971 2141892 PK04_097176 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I19 compound treatment 1.58436248E8 6030000.0 0.16 1.68090987E8 2000000.0 0.06 0.1515 0.9034 2141687 PK04_097177 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I20 compound treatment 1.56834152E8 4430000.0 0.12 1.6622838E8 134000.0 0.0 0.0847 0.7297 2141680 PK04_097178 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I21 mock treatment 1.80355627E8 2.8E7 0.73 1.87402874E8 2.13E7 0.6 0.942 0.9952 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I22 mock treatment 1.82906348E8 3.05E7 0.8 1.86816371E8 2.07E7 0.58 0.9776 0.9882 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I23 compound treatment 1.71544058E8 1.91E7 0.5 1.83811687E8 1.77E7 0.5 0.7074 1.0 2141841 PK04_097179 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 I24 compound treatment 1.57594802E8 5190000.0 0.14 1.57081476E8 -9010000.0 -0.25 -0.0835 -0.2897 2141766 PK04_097180 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J01 compound treatment 1.48933056E8 -3470000.0 -0.09 1.53446358E8 -1.26E7 -0.36 -0.3162 -0.8598 2141705 PK04_097181 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J02 compound treatment 7.7611814E7 -7.48E7 -1.96 9.710679E7 -6.9E7 -1.94 -2.759 -1.0 2143397 PK04_097182 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J03 compound treatment 1.52608029E8 207000.0 0.01 1.7629201E8 1.02E7 0.29 0.207 0.7203 2141179 PK04_097183 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J04 compound treatment 1.57810333E8 5410000.0 0.14 1.75114661E8 9020000.0 0.25 0.2799 0.9618 2144337 PK04_097184 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J05 mock treatment 1.42833881E8 -9570000.0 -0.25 1.58383445E8 -7710000.0 -0.22 -0.3307 -0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J06 mock treatment 1.40563889E8 -1.18E7 -0.31 1.5605627E8 -1.0E7 -0.28 -0.4191 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J07 compound treatment 1.41552291E8 -1.08E7 -0.28 1.6350069E8 -2590000.0 -0.07 -0.2525 -0.861 2141805 PK04_097185 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J08 compound treatment 1.23874618E8 -2.85E7 -0.75 1.48677487E8 -1.74E7 -0.49 -0.8751 -0.9793 2143365 PK04_097186 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J09 compound treatment 9.5007066E7 -5.74E7 -1.5 1.07873451E8 -5.82E7 -1.64 -2.2225 -0.999 2141901 PK04_097187 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J10 compound treatment 8.453632E7 -6.79E7 -1.78 1.00634044E8 -6.55E7 -1.84 -2.5606 -0.9998 2144881 PK04_097188 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J11 compound treatment 1.38728182E8 -1.37E7 -0.36 1.52740312E8 -1.34E7 -0.38 -0.5192 -0.9997 2141717 PK04_097189 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J12 compound treatment 5.6831569E7 -9.56E7 -2.5 6.5033611E7 -1.01E8 -2.85 -3.7828 -0.9979 2143405 PK04_097190 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J13 compound treatment 1.32638667E8 -1.98E7 -0.52 1.5713108E8 -8960000.0 -0.25 -0.5444 -0.9457 2141188 PK04_097191 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J14 compound treatment 1.24530028E8 -2.79E7 -0.73 1.37989627E8 -2.81E7 -0.79 -1.0759 -0.9992 2142929 PK04_097192 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J15 compound treatment 1.26081712E8 -2.63E7 -0.69 1.41209944E8 -2.49E7 -0.7 -0.983 -1.0 2141365 PK04_097193 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J16 compound treatment 1.59928992E8 7530000.0 0.2 1.66134922E8 40600.0 0.0 0.1401 0.7112 2144325 PK04_097194 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J17 compound treatment 3.6973429E7 -1.15E8 -3.02 4.3940248E7 -1.22E8 -3.44 -4.5707 -0.9979 2141221 PK04_097195 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J18 compound treatment 1.69583485E8 1.72E7 0.45 1.75700893E8 9610000.0 0.27 0.5095 0.9705 2143377 PK04_097196 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J19 compound treatment 1.63294738E8 1.09E7 0.29 1.68659306E8 2560000.0 0.07 0.2527 0.8592 2141815 PK04_097197 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J20 compound treatment 1.17053703E8 -3.53E7 -0.93 1.21859098E8 -4.42E7 -1.25 -1.5357 -0.9892 2142585 PK04_097198 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J21 mock treatment 1.79911864E8 2.75E7 0.72 1.92416011E8 2.63E7 0.74 1.0337 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J22 mock treatment 1.83743624E8 3.13E7 0.82 1.9769609E8 3.16E7 0.89 1.2099 0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J23 compound treatment 1.91239278E8 3.88E7 1.02 2.00981066E8 3.49E7 0.98 1.4141 0.9999 2141186 PK04_097199 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 J24 compound treatment 2.16899004E8 6.45E7 1.69 2.22479972E8 5.64E7 1.59 2.3174 0.9995 2144237 PK04_097200 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K01 compound treatment 1.75280915E8 2.29E7 0.6 2.00905857E8 3.48E7 0.98 1.1172 0.972 2141164 PK04_097201 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K02 compound treatment 1.44066474E8 -8340000.0 -0.22 1.83244218E8 1.71E7 0.48 0.1875 0.3535 2141443 PK04_097202 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K03 compound treatment 1.04033011E8 -4.84E7 -1.27 1.29557005E8 -3.65E7 -1.03 -1.6234 -0.9947 2141548 PK04_097203 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K04 compound treatment 1.47761792E8 -4640000.0 -0.12 1.71446951E8 5350000.0 0.15 0.0208 0.1073 2141351 PK04_097204 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K05 compound treatment 1.4199891E8 -1.04E7 -0.27 1.56394343E8 -9700000.0 -0.27 -0.3858 -1.0 2141786 PK04_097205 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K06 compound treatment 1.00433105E8 -5.2E7 -1.36 1.07529421E8 -5.86E7 -1.65 -2.1289 -0.9954 2141746 PK04_097206 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K07 mock treatment 1.35313937E8 -1.71E7 -0.45 1.57840124E8 -8250000.0 -0.23 -0.4808 -0.9536 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K08 mock treatment 1.37885974E8 -1.45E7 -0.38 1.60569935E8 -5520000.0 -0.16 -0.3788 -0.9224 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K09 compound treatment 5.3286479E7 -9.91E7 -2.59 5.9366906E7 -1.07E8 -3.01 -3.9613 -0.9973 2141350 PK04_097207 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K10 compound treatment 2.8872767E7 -1.24E8 -3.23 3.2539532E7 -1.34E8 -3.76 -4.9478 -0.9971 2141331 PK04_097208 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K11 compound treatment 1.43836751E8 -8560000.0 -0.22 1.60496302E8 -5600000.0 -0.16 -0.2701 -0.9852 2141806 PK04_097209 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K12 compound treatment 1.28143126E8 -2.43E7 -0.64 1.40304178E8 -2.58E7 -0.73 -0.9629 -0.9977 2141720 PK04_097210 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K13 compound treatment 9.9208327E7 -5.32E7 -1.39 1.13135383E8 -5.3E7 -1.49 -2.0399 -0.9994 2141904 PK04_097211 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K14 compound treatment 1.0050151E8 -5.19E7 -1.36 1.29109276E8 -3.7E7 -1.04 -1.6976 -0.9914 2141222 PK04_097212 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K15 mock treatment 1.51571648E8 -830000.0 -0.02 1.67454116E8 1360000.0 0.04 0.0117 0.2664 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K16 mock treatment 1.61342614E8 8940000.0 0.23 1.71967491E8 5870000.0 0.17 0.2825 0.9856 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K17 compound treatment 1.4519397E8 -7210000.0 -0.19 1.58564398E8 -7530000.0 -0.21 -0.2835 -0.9983 2141773 PK04_097213 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K18 compound treatment 1.63511952E8 1.11E7 0.29 1.72566435E8 6470000.0 0.18 0.3346 0.9747 2141524 PK04_097214 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K19 compound treatment 1.49146889E8 -3250000.0 -0.09 1.59741323E8 -6350000.0 -0.18 -0.1868 -0.9423 2141218 PK04_097215 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K20 compound treatment 1.63837529E8 1.14E7 0.3 1.73442533E8 7350000.0 0.21 0.3581 0.9838 2141861 PK04_097216 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K21 compound treatment 1.77285529E8 2.49E7 0.65 1.83944445E8 1.79E7 0.5 0.8163 0.9918 2141117 PK04_097217 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K22 compound treatment 1.47542684E8 -4860000.0 -0.13 1.4904997E8 -1.7E7 -0.48 -0.4296 -0.8646 2141354 PK04_097218 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K23 mock treatment 1.85527964E8 3.31E7 0.87 1.95846449E8 2.98E7 0.84 1.206 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 K24 mock treatment 2.17996557E8 6.56E7 1.72 2.26036901E8 5.99E7 1.69 2.4086 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L01 compound treatment 1.18736911E8 -3.37E7 -0.88 1.30644147E8 -3.55E7 -1.0 -1.3295 -0.998 2141684 PK04_097219 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L02 compound treatment 1.253742E8 -2.7E7 -0.71 1.50392573E8 -1.57E7 -0.44 -0.8132 -0.9745 2143489 PK04_097220 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L03 compound treatment 2.8712902E7 -1.24E8 -3.24 2.8992363E7 -1.37E8 -3.86 -5.0214 -0.9961 2141375 PK04_097221 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L04 compound treatment 1.26565373E8 -2.58E7 -0.68 1.50238581E8 -1.59E7 -0.45 -0.7942 -0.9798 2143313 PK04_097222 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L05 compound treatment 1.14233225E8 -3.82E7 -1.0 1.34504213E8 -3.16E7 -0.89 -1.336 -0.9983 2141889 PK04_097223 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L06 compound treatment 1.09501614E8 -4.29E7 -1.12 1.33579563E8 -3.25E7 -0.92 -1.442 -0.9949 2144793 PK04_097224 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L07 mock treatment 1.43384101E8 -9020000.0 -0.24 1.66863664E8 769000.0 0.02 -0.1516 -0.6395 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L08 mock treatment 1.39872698E8 -1.25E7 -0.33 1.57996358E8 -8100000.0 -0.23 -0.3933 -0.9843 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L09 compound treatment 1.37496466E8 -1.49E7 -0.39 1.62778249E8 -3320000.0 -0.09 -0.342 -0.8524 2141438 PK04_097225 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L10 compound treatment 1.39888427E8 -1.25E7 -0.33 1.63045008E8 -3050000.0 -0.09 -0.2924 -0.8634 2142993 PK04_097226 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L11 compound treatment 1.29853005E8 -2.25E7 -0.59 1.52344231E8 -1.38E7 -0.39 -0.6914 -0.9792 2141185 PK04_097227 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L12 compound treatment 1.24369232E8 -2.8E7 -0.73 1.38772163E8 -2.73E7 -0.77 -1.0633 -0.9997 2144653 PK04_097228 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L13 compound treatment 9.3248069E7 -5.92E7 -1.55 1.06928821E8 -5.92E7 -1.67 -2.2739 -0.9993 2141893 PK04_097229 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L14 compound treatment 1.3613846E8 -1.63E7 -0.43 1.51411167E8 -1.47E7 -0.41 -0.5936 -0.9999 2143417 PK04_097230 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L15 mock treatment 1.52916392E8 515000.0 0.01 1.65430077E8 -664000.0 -0.02 -0.0037 -0.1606 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L16 mock treatment 1.59661968E8 7260000.0 0.19 1.65899109E8 -195000.0 -0.01 0.1305 0.6864 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L17 compound treatment 1.60487027E8 8090000.0 0.21 1.64055989E8 -2040000.0 -0.06 0.109 0.4972 2141152 PK04_097231 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L18 compound treatment 1.52554587E8 153000.0 0.0 1.59934053E8 -6160000.0 -0.17 -0.1199 -0.6906 2143325 PK04_097232 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L19 compound treatment 1.3990277E8 -1.25E7 -0.33 1.46213392E8 -1.99E7 -0.56 -0.6275 -0.9672 2141709 PK04_097233 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L20 compound treatment 1.2758817E8 -2.48E7 -0.65 1.3323707E8 -3.29E7 -0.93 -1.114 -0.985 2142773 PK04_097234 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L21 compound treatment 1.64869775E8 1.25E7 0.33 1.64453369E8 -1640000.0 -0.05 0.1981 0.6009 2141174 PK04_097235 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L22 compound treatment 1.68191022E8 1.58E7 0.41 1.76808458E8 1.07E7 0.3 0.5058 0.9881 2142985 PK04_097236 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L23 mock treatment 1.86052552E8 3.37E7 0.88 2.025549E8 3.65E7 1.03 1.3494 0.9971 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 L24 mock treatment 2.10498084E8 5.81E7 1.52 2.31548937E8 6.55E7 1.84 2.3796 0.9954 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M01 compound treatment 1.8548699E8 3.31E7 0.87 1.96544448E8 3.05E7 0.86 1.2192 1.0 2141838 PK04_097237 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M02 compound treatment 1.32415477E8 -2.0E7 -0.52 1.40479478E8 -2.56E7 -0.72 -0.8804 -0.9875 2141189 PK04_097238 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M03 compound treatment 9.3424616E7 -5.9E7 -1.54 1.08397218E8 -5.77E7 -1.63 -2.2414 -0.9997 2141724 PK04_097239 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M04 compound treatment 9.9577878E7 -5.28E7 -1.38 1.13788844E8 -5.23E7 -1.47 -2.02 -0.9995 2141153 PK04_097240 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M05 compound treatment 1.55423857E8 3020000.0 0.08 1.80206287E8 1.41E7 0.4 0.3371 0.8315 2141436 PK04_097241 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M06 compound treatment 1.26204037E8 -2.62E7 -0.69 1.38046962E8 -2.8E7 -0.79 -1.0438 -0.9975 2141769 PK04_097242 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M07 compound treatment 9.4405109E7 -5.8E7 -1.52 1.14269559E8 -5.18E7 -1.46 -2.1062 -0.9998 2141771 PK04_097243 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M08 compound treatment 1.09106461E8 -4.33E7 -1.13 1.20602436E8 -4.55E7 -1.28 -1.7079 -0.9981 2141480 PK04_097244 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M09 mock treatment 1.52139398E8 -262000.0 -0.01 1.68788153E8 2690000.0 0.08 0.0488 0.6406 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M10 mock treatment 1.42779463E8 -9620000.0 -0.25 1.619807E8 -4110000.0 -0.12 -0.2601 -0.938 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M11 compound treatment 6.1565275E7 -9.08E7 -2.38 9.1989868E7 -7.41E7 -2.09 -3.158 -0.9979 2141571 PK04_097245 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M12 compound treatment 3.8801411E7 -1.14E8 -2.97 4.0964733E7 -1.25E8 -3.53 -4.5961 -0.9964 2141879 PK04_097246 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M13 mock treatment 1.47692814E8 -4710000.0 -0.12 1.68227282E8 2130000.0 0.06 -0.0447 -0.3256 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M14 mock treatment 1.4559397E8 -6810000.0 -0.18 1.53556485E8 -1.25E7 -0.35 -0.3758 -0.9498 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M15 compound treatment 8.1088306E7 -7.13E7 -1.87 8.6068738E7 -8.0E7 -2.26 -2.9146 -0.9956 2141832 PK04_097247 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M16 compound treatment 1.50334089E8 -2070000.0 -0.05 1.57006758E8 -9090000.0 -0.26 -0.2194 -0.838 2141542 PK04_097248 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M17 compound treatment 9.1195572E7 -6.12E7 -1.6 9.8916926E7 -6.72E7 -1.89 -2.4715 -0.9966 2141399 PK04_097249 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M18 compound treatment 1.55976872E8 3580000.0 0.09 1.68162054E8 2070000.0 0.06 0.1074 0.974 2141903 PK04_097250 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M19 compound treatment 3.0630411E7 -1.22E8 -3.19 3.037266E7 -1.36E8 -3.82 -4.9584 -0.9959 2141716 PK04_097251 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M20 compound treatment 1.64187948E8 1.18E7 0.31 1.5648674E8 -9610000.0 -0.27 0.0267 0.0651 2141203 PK04_097252 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M21 compound treatment 1.81829224E8 2.94E7 0.77 1.88991169E8 2.29E7 0.65 1.001 0.9961 2141110 PK04_097253 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M22 compound treatment 1.01943533E8 -5.05E7 -1.32 1.06459931E8 -5.96E7 -1.68 -2.1223 -0.9929 2141731 PK04_097254 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M23 compound treatment 1.76637742E8 2.42E7 0.63 1.91898463E8 2.58E7 0.73 0.9628 0.9977 2141095 PK04_097255 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 M24 compound treatment 1.58099837E8 5700000.0 0.15 1.93946933E8 2.79E7 0.78 0.6605 0.8267 2141894 PK04_097256 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N01 compound treatment 1.97551622E8 4.52E7 1.18 2.10725597E8 4.46E7 1.26 1.7251 0.9995 2141340 PK04_097257 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N02 compound treatment 1.64863396E8 1.25E7 0.33 1.75348846E8 9250000.0 0.26 0.4151 0.9938 2142089 PK04_097258 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N03 compound treatment 1.51674683E8 -727000.0 -0.02 1.65220146E8 -874000.0 -0.02 -0.0309 -0.9918 2141511 PK04_097259 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N04 compound treatment 1.4733923E8 -5060000.0 -0.13 1.6016791E8 -5930000.0 -0.17 -0.2118 -0.9934 2144305 PK04_097260 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N05 compound treatment 1.20882709E8 -3.15E7 -0.83 1.37138783E8 -2.9E7 -0.82 -1.1604 -1.0 2141839 PK04_097261 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N06 compound treatment 1.42098958E8 -1.03E7 -0.27 1.58470768E8 -7620000.0 -0.21 -0.3426 -0.9937 2142057 PK04_097262 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N07 compound treatment 1.42707658E8 -9690000.0 -0.25 1.58362255E8 -7730000.0 -0.22 -0.3335 -0.9971 2141431 PK04_097263 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N08 compound treatment 1.33376799E8 -1.9E7 -0.5 1.49606806E8 -1.65E7 -0.46 -0.6807 -0.9994 2144369 PK04_097264 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N09 mock treatment 1.44478385E8 -7920000.0 -0.21 1.4922391E8 -1.69E7 -0.48 -0.4828 -0.9309 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N10 mock treatment 1.3930314E8 -1.31E7 -0.34 1.6141675E8 -4680000.0 -0.13 -0.3357 -0.9138 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N11 compound treatment 1.46652342E8 -5750000.0 -0.15 1.59165338E8 -6930000.0 -0.2 -0.2445 -0.9917 2141527 PK04_097265 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N12 compound treatment 1.51925917E8 -476000.0 -0.01 1.73486319E8 7390000.0 0.21 0.1385 0.6637 2144009 PK04_097266 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N13 mock treatment 1.44421863E8 -7980000.0 -0.21 1.51775787E8 -1.43E7 -0.4 -0.433 -0.953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N14 mock treatment 1.49121116E8 -3280000.0 -0.09 1.43323792E8 -2.28E7 -0.64 -0.5145 -0.7946 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N15 compound treatment 1.37611503E8 -1.48E7 -0.39 1.4907343E8 -1.7E7 -0.48 -0.6129 -0.9944 2141907 PK04_097267 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N16 compound treatment 9.8344347E7 -5.41E7 -1.42 1.12305037E8 -5.38E7 -1.52 -2.0724 -0.9994 2143157 PK04_097268 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N17 compound treatment 1.64417943E8 1.2E7 0.31 1.84166403E8 1.81E7 0.51 0.5825 0.9732 2141544 PK04_097269 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N18 compound treatment 1.46376184E8 -6030000.0 -0.16 1.62282352E8 -3810000.0 -0.11 -0.1875 -0.9825 2144297 PK04_097270 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N19 compound treatment 1.0678627E8 -4.56E7 -1.19 1.15586474E8 -5.05E7 -1.42 -1.8508 -0.9962 2141483 PK04_097271 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N20 compound treatment 1.59633309E8 7230000.0 0.19 1.64273935E8 -1820000.0 -0.05 0.0976 0.4975 2142217 PK04_097272 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N21 compound treatment 1.72520813E8 2.01E7 0.53 1.65832705E8 -262000.0 -0.01 0.3672 0.6971 2141887 PK04_097273 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N22 compound treatment 1.71598817E8 1.92E7 0.5 1.6978896E8 3690000.0 0.1 0.429 0.8359 2143065 PK04_097274 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N23 compound treatment 1.5235885E8 -42600.0 0.0 1.58303436E8 -7790000.0 -0.22 -0.156 -0.7107 2141817 PK04_097275 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 N24 compound treatment 2.15248799E8 6.28E7 1.65 2.25878872E8 5.98E7 1.68 2.3546 0.9999 2144333 PK04_097276 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O01 compound treatment 2.08735408E8 5.63E7 1.47 2.12427003E8 4.63E7 1.31 1.966 0.9982 2141166 PK04_097277 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O02 compound treatment 1.4512992E8 -7270000.0 -0.19 1.41352003E8 -2.47E7 -0.7 -0.6276 -0.8684 2141900 PK04_097278 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O03 compound treatment 1.69243138E8 1.68E7 0.44 1.85007348E8 1.89E7 0.53 0.6886 0.9956 2141790 PK04_097279 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O04 compound treatment 8.1643744E7 -7.08E7 -1.85 9.4606182E7 -7.15E7 -2.01 -2.7342 -0.9991 2141883 PK04_097280 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O05 compound treatment 1.59203149E8 6800000.0 0.18 1.71302633E8 5210000.0 0.15 0.2297 0.9954 2141427 PK04_097281 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O06 compound treatment 1.45357517E8 -7040000.0 -0.18 1.63975439E8 -2120000.0 -0.06 -0.1726 -0.8906 2141093 PK04_097282 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O07 compound treatment 1.39545096E8 -1.29E7 -0.34 1.57821671E8 -8270000.0 -0.23 -0.4028 -0.9839 2141812 PK04_097283 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O08 compound treatment 1.48332444E8 -4070000.0 -0.11 1.60962458E8 -5130000.0 -0.14 -0.1776 -0.9887 2141430 PK04_097284 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O09 compound treatment 1.51135543E8 -1270000.0 -0.03 1.65067339E8 -1030000.0 -0.03 -0.0439 -0.9977 2141454 PK04_097285 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O10 compound treatment 1.47742035E8 -4660000.0 -0.12 1.61122744E8 -4970000.0 -0.14 -0.1853 -0.9976 2141529 PK04_097286 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O11 mock treatment 1.47278925E8 -5120000.0 -0.13 1.56501565E8 -9590000.0 -0.27 -0.286 -0.9477 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O12 mock treatment 1.52760027E8 359000.0 0.01 1.62948421E8 -3150000.0 -0.09 -0.0561 -0.6287 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O13 compound treatment 1.45550541E8 -6850000.0 -0.18 1.55900454E8 -1.02E7 -0.29 -0.3299 -0.9743 2141368 PK04_097287 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O14 compound treatment 5.8542855E7 -9.39E7 -2.46 6.5921451E7 -1.0E8 -2.82 -3.7334 -0.9976 2141362 PK04_097288 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O15 compound treatment 1.39114283E8 -1.33E7 -0.35 1.55172705E8 -1.09E7 -0.31 -0.4636 -0.9981 2141460 PK04_097289 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O16 compound treatment 9.6596322E7 -5.58E7 -1.46 1.1121679E8 -5.49E7 -1.55 -2.1265 -0.9996 2141860 PK04_097290 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O17 compound treatment 1.62409583E8 1.0E7 0.26 1.89628489E8 2.35E7 0.66 0.6542 0.9174 2141175 PK04_097291 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O18 compound treatment 1.47163524E8 -5240000.0 -0.14 1.60508159E8 -5590000.0 -0.16 -0.2083 -0.9976 2141486 PK04_097292 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O19 compound treatment 8.4194797E7 -6.82E7 -1.79 9.3478304E7 -7.26E7 -2.05 -2.7095 -0.9977 2141156 PK04_097293 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O20 compound treatment 1.3369367E8 -1.87E7 -0.49 1.39220707E8 -2.69E7 -0.76 -0.8818 -0.9777 2141685 PK04_097294 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O21 compound treatment 1.84706024E8 3.23E7 0.85 1.93223113E8 2.71E7 0.76 1.1385 0.9987 2141094 PK04_097295 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O22 compound treatment 1.1498205E8 -3.74E7 -0.98 1.20011579E8 -4.61E7 -1.3 -1.6109 -0.9903 2141379 PK04_097296 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O23 compound treatment 3.1542617E7 -1.21E8 -3.16 3.3128583E7 -1.33E8 -3.75 -4.8866 -0.9965 2141397 PK04_097297 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 O24 compound treatment 2.21495008E8 6.91E7 1.81 2.30826792E8 6.47E7 1.82 2.5688 1.0 2065842 PK04_097298 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P01 compound treatment 1.78652936E8 2.63E7 0.69 1.76781768E8 1.07E7 0.3 0.6989 0.9315 2141898 PK04_097299 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P02 compound treatment 1.72501809E8 2.01E7 0.53 1.62424481E8 -3670000.0 -0.1 0.2989 0.5575 2143305 PK04_097300 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P03 compound treatment 1.65322036E8 1.29E7 0.34 1.81665016E8 1.56E7 0.44 0.5494 0.9917 2141555 PK04_097301 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P04 compound treatment 1.57935212E8 5530000.0 0.14 1.68781013E8 2690000.0 0.08 0.156 0.9542 2144945 PK04_097302 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P05 compound treatment 2.9506966E7 -1.23E8 -3.22 3.3646265E7 -1.32E8 -3.73 -4.914 -0.9973 2141923 PK04_097303 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P06 compound treatment 1.6508193E8 1.27E7 0.33 1.77615313E8 1.15E7 0.32 0.4643 0.9999 2144433 PK04_097304 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P07 compound treatment 1.73005558E8 2.06E7 0.54 1.88874789E8 2.28E7 0.64 0.8353 0.9962 2141482 PK04_097305 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P08 compound treatment 1.72857876E8 2.05E7 0.54 1.7985169E8 1.38E7 0.39 0.6528 0.9874 2143929 PK04_097306 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P09 compound treatment 1.70807873E8 1.84E7 0.48 1.82036271E8 1.59E7 0.45 0.6584 0.9994 2141698 PK04_097307 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P10 compound treatment 1.73031778E8 2.06E7 0.54 1.91240062E8 2.51E7 0.71 0.8829 0.991 2142653 PK04_097308 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P11 mock treatment 1.76012126E8 2.36E7 0.62 1.88635893E8 2.25E7 0.64 0.8862 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P12 mock treatment 1.73455053E8 2.11E7 0.55 1.86323437E8 2.02E7 0.57 0.7928 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P13 compound treatment 1.77594273E8 2.52E7 0.66 1.90678334E8 2.46E7 0.69 0.9562 0.9997 2141449 PK04_097309 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P14 compound treatment 1.58088515E8 5690000.0 0.15 1.78673164E8 1.26E7 0.35 0.3559 0.9257 2144933 PK04_097310 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P15 compound treatment 1.59333936E8 6930000.0 0.18 1.76351556E8 1.03E7 0.29 0.3327 0.9748 2141416 PK04_097311 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P16 compound treatment 1.04116257E8 -4.83E7 -1.26 1.20276582E8 -4.58E7 -1.29 -1.8067 -0.9999 2144445 PK04_097312 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P17 compound treatment 1.64476318E8 1.21E7 0.32 1.88770422E8 2.27E7 0.64 0.6754 0.9473 2141453 PK04_097313 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P18 compound treatment 4.9276585E7 -1.03E8 -2.7 4.5435388E7 -1.21E8 -3.4 -4.3131 -0.9935 2142745 PK04_097314 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P19 compound treatment 1.88317393E8 3.59E7 0.94 2.04179811E8 3.81E7 1.07 1.4237 0.9978 2141541 PK04_097315 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P20 compound treatment 1.61343973E8 8940000.0 0.23 1.70803148E8 4710000.0 0.13 0.2594 0.9639 2142193 PK04_097316 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P21 compound treatment 1.99534547E8 4.71E7 1.23 2.12105699E8 4.6E7 1.3 1.7893 0.9997 2141134 PK04_097317 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P22 compound treatment 1.83719642E8 3.13E7 0.82 1.82619206E8 1.65E7 0.47 0.909 0.9641 2142729 PK04_097318 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P23 compound treatment 2.21735506E8 6.93E7 1.81 2.24925011E8 5.88E7 1.66 2.4557 0.999 2141121 PK04_097319 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2097 P24 compound treatment 2.6216564E8 1.1E8 2.87 2.5710275E8 9.1E7 2.56 3.8452 0.9984 2144273 PK04_097320 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A01 compound treatment 2.13894822E8 5.72E7 1.5 2.1294927E8 5.43E7 1.53 2.1418 0.9999 2141696 PK04_098001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A02 compound treatment 1.32974465E8 -2.37E7 -0.62 1.22062342E8 -3.66E7 -1.03 -1.1671 -0.9705 2144133 PK04_098002 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A03 compound treatment 1.65468962E8 8810000.0 0.23 1.71994126E8 1.34E7 0.38 0.4294 0.9722 2141089 PK04_098003 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A04 compound treatment 1.80138533E8 2.35E7 0.61 1.82796527E8 2.42E7 0.68 0.9162 0.9987 2142093 PK04_098004 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A05 compound treatment 5.991856E7 -9.67E7 -2.53 6.5493627E7 -9.31E7 -2.62 -3.6465 -0.9998 2141744 PK04_098005 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A06 compound treatment 1.0242562E8 -5.42E7 -1.42 1.10420627E8 -4.82E7 -1.36 -1.9645 -0.9998 2143237 PK04_098006 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A07 compound treatment 1.62319778E8 5660000.0 0.15 1.67446248E8 8820000.0 0.25 0.2805 0.9694 2141337 PK04_098007 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A08 compound treatment 9.4739325E7 -6.19E7 -1.62 1.03551713E8 -5.51E7 -1.55 -2.2436 -0.9998 2144129 PK04_098008 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A09 compound treatment 1.52794013E8 -3870000.0 -0.1 1.58104059E8 -523000.0 -0.01 -0.082 -0.8015 2141791 PK04_098009 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A10 compound treatment 1.34315936E8 -2.23E7 -0.58 1.48645739E8 -9980000.0 -0.28 -0.6125 -0.9437 2144193 PK04_098010 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A11 compound treatment 1.0215085E8 -5.45E7 -1.43 1.16910104E8 -4.17E7 -1.18 -1.8403 -0.9954 2141133 PK04_098011 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A12 compound treatment 1.31609313E8 -2.51E7 -0.66 1.3478114E8 -2.38E7 -0.67 -0.9389 -0.9999 2143993 PK04_098012 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A13 mock treatment 1.52081468E8 -4580000.0 -0.12 1.605979E8 1970000.0 0.06 -0.0455 -0.3444 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A14 mock treatment 1.4686407E8 -9800000.0 -0.26 1.46640861E8 -1.2E7 -0.34 -0.4202 -0.9908 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A15 compound treatment 1.48148759E8 -8510000.0 -0.22 1.49702468E8 -8920000.0 -0.25 -0.3354 -0.9982 2141695 PK04_098013 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A16 compound treatment 1.62466259E8 5800000.0 0.15 1.5699895E8 -1630000.0 -0.05 0.075 0.4725 2144913 PK04_098014 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A17 compound treatment 1.56242798E8 -420000.0 -0.01 1.56281228E8 -2350000.0 -0.07 -0.0545 -0.8135 2141801 PK04_098015 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A18 compound treatment 1.10519476E8 -4.61E7 -1.21 1.11977556E8 -4.66E7 -1.31 -1.7837 -0.9991 2142117 PK04_098016 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A19 compound treatment 1.66829669E8 1.02E7 0.27 1.63984222E8 5360000.0 0.15 0.2949 0.9639 2141835 PK04_098017 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A20 compound treatment 1.57609624E8 947000.0 0.02 1.47933596E8 -1.07E7 -0.3 -0.1955 -0.6467 2144205 PK04_098018 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A21 compound treatment 1.36015226E8 -2.06E7 -0.54 1.34994382E8 -2.36E7 -0.67 -0.8531 -0.9946 2141920 PK04_098019 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A22 compound treatment 1.55193444E8 -1470000.0 -0.04 1.56314806E8 -2310000.0 -0.07 -0.0733 -0.9684 2141945 PK04_098020 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A23 compound treatment 1.83058484E8 2.64E7 0.69 1.80136933E8 2.15E7 0.61 0.9172 0.9979 2141111 PK04_098021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 A24 compound treatment 1.37671424E8 -1.9E7 -0.5 1.44602234E8 -1.4E7 -0.4 -0.631 -0.9935 2143385 PK04_098022 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B01 compound treatment 3.7012889E7 -1.2E8 -3.13 3.7725274E7 -1.21E8 -3.41 -4.6238 -0.9991 2142845 PK04_098023 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B02 compound treatment 1.53294381E8 -3370000.0 -0.09 1.55363385E8 -3260000.0 -0.09 -0.1274 -0.9998 2143009 PK04_098024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B03 compound treatment 1.49461344E8 -7200000.0 -0.19 1.55064792E8 -3560000.0 -0.1 -0.2043 -0.9565 2144209 PK04_098025 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B04 compound treatment 1.33219608E8 -2.34E7 -0.61 1.39953673E8 -1.87E7 -0.53 -0.806 -0.9971 2142037 PK04_098026 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B05 compound treatment 1.50460614E8 -6200000.0 -0.16 1.58455084E8 -172000.0 0.0 -0.1182 -0.7278 2144313 PK04_098027 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B06 compound treatment 9.721204E7 -5.95E7 -1.56 8.284872E7 -7.58E7 -2.14 -2.6104 -0.9879 2143245 PK04_098028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B07 compound treatment 1.34392768E8 -2.23E7 -0.58 1.38737899E8 -1.99E7 -0.56 -0.8085 -0.9998 2144661 PK04_098029 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B08 compound treatment 9.3595094E7 -6.31E7 -1.65 9.7315165E7 -6.13E7 -1.73 -2.3891 -0.9997 2143409 PK04_098030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B09 compound treatment 1.23226407E8 -3.34E7 -0.88 1.24741016E8 -3.39E7 -0.95 -1.2941 -0.9991 2144745 PK04_098031 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B10 compound treatment 1.35122223E8 -2.15E7 -0.56 1.24137466E8 -3.45E7 -0.97 -1.086 -0.9665 2143049 PK04_098032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B11 compound treatment 1.23489159E8 -3.32E7 -0.87 1.3237951E8 -2.62E7 -0.74 -1.137 -0.9968 2143257 PK04_098033 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B12 compound treatment 1.02694567E8 -5.4E7 -1.41 1.04163929E8 -5.45E7 -1.53 -2.0842 -0.9991 2141502 PK04_098034 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B13 mock treatment 1.1795564E8 -3.87E7 -1.01 1.36328093E8 -2.23E7 -0.63 -1.1608 -0.9736 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B14 mock treatment 1.28132833E8 -2.85E7 -0.75 1.27801761E8 -3.08E7 -0.87 -1.1423 -0.9972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B15 compound treatment 9.4654032E7 -6.2E7 -1.62 9.1418215E7 -6.72E7 -1.89 -2.487 -0.997 2142113 PK04_098035 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B16 compound treatment 1.26889272E8 -2.98E7 -0.78 1.33330997E8 -2.53E7 -0.71 -1.0552 -0.999 2141859 PK04_098036 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B17 compound treatment 8.0799113E7 -7.59E7 -1.99 7.8009023E7 -8.06E7 -2.27 -3.0106 -0.9978 2144033 PK04_098037 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B18 compound treatment 1.4229408E8 -1.44E7 -0.38 1.41088501E8 -1.75E7 -0.49 -0.6154 -0.9909 2141540 PK04_098038 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B19 compound treatment 1.25065598E8 -3.16E7 -0.83 1.24379553E8 -3.42E7 -0.97 -1.2673 -0.997 2144437 PK04_098039 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B20 compound treatment 6.0578588E7 -9.61E7 -2.52 5.8441471E7 -1.0E8 -2.82 -3.7748 -0.9983 2144725 PK04_098040 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B21 compound treatment 1.31396405E8 -2.53E7 -0.66 1.33750731E8 -2.49E7 -0.7 -0.9634 -0.9996 2143413 PK04_098041 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B22 compound treatment 1.48205741E8 -8460000.0 -0.22 1.49573925E8 -9050000.0 -0.26 -0.3369 -0.9975 2141509 PK04_098042 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B23 compound treatment 1.73531695E8 1.69E7 0.44 1.76311577E8 1.77E7 0.5 0.6646 0.9982 2142009 PK04_098043 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 B24 compound treatment 1.98559675E8 4.19E7 1.1 2.02271023E8 4.36E7 1.23 1.6452 0.9984 2141342 PK04_098044 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C01 compound treatment 1.9414754E8 3.75E7 0.98 1.94334979E8 3.57E7 1.01 1.4054 0.9999 2141145 PK04_098045 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C02 compound treatment 1.43948579E8 -1.27E7 -0.33 1.45551539E8 -1.31E7 -0.37 -0.4959 -0.9987 2143097 PK04_098046 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C03 compound treatment 1.4168963E8 -1.5E7 -0.39 1.57800698E8 -826000.0 -0.02 -0.2936 -0.7478 2141834 PK04_098047 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C04 compound treatment 4.8936326E7 -1.08E8 -2.82 4.8984659E7 -1.1E8 -3.09 -4.1788 -0.999 2142605 PK04_098048 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C05 compound treatment 7.3642173E7 -8.3E7 -2.17 8.2999311E7 -7.56E7 -2.13 -3.0437 -1.0 2141398 PK04_098049 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C06 compound treatment 1.37480329E8 -1.92E7 -0.5 1.43103753E8 -1.55E7 -0.44 -0.6644 -0.9976 2143013 PK04_098050 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C07 compound treatment 1.49156079E8 -7510000.0 -0.2 1.6237668E8 3750000.0 0.11 -0.0642 -0.2878 2141793 PK04_098051 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C08 compound treatment 1.33654466E8 -2.3E7 -0.6 1.39859885E8 -1.88E7 -0.53 -0.7998 -0.9979 2143277 PK04_098052 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C09 compound treatment 4.5352923E7 -1.11E8 -2.91 4.7400098E7 -1.11E8 -3.13 -4.2767 -0.9993 2141681 PK04_098053 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C10 compound treatment 3.6081292E7 -1.21E8 -3.16 4.2961877E7 -1.16E8 -3.26 -4.5367 -0.9999 2144125 PK04_098054 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C11 mock treatment 1.48769369E8 -7890000.0 -0.21 1.55913567E8 -2710000.0 -0.08 -0.2002 -0.9086 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C12 mock treatment 1.20750703E8 -3.59E7 -0.94 1.40672761E8 -1.8E7 -0.51 -1.0225 -0.9578 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C13 compound treatment 4.6170708E7 -1.1E8 -2.89 4.8596665E7 -1.1E8 -3.1 -4.2377 -0.9994 2141376 PK04_098055 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C14 compound treatment 1.22760766E8 -3.39E7 -0.89 1.24912699E8 -3.37E7 -0.95 -1.2993 -0.9994 2143897 PK04_098056 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C15 mock treatment 1.27715576E8 -2.89E7 -0.76 1.30511951E8 -2.81E7 -0.79 -1.096 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C16 mock treatment 1.33471157E8 -2.32E7 -0.61 1.26265057E8 -3.24E7 -0.91 -1.0741 -0.9804 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C17 compound treatment 1.5101417E8 -5650000.0 -0.15 1.45212552E8 -1.34E7 -0.38 -0.3718 -0.9161 2141461 PK04_098057 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C18 compound treatment 1.18064021E8 -3.86E7 -1.01 1.15014675E8 -4.36E7 -1.23 -1.5835 -0.9953 2143145 PK04_098058 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C19 compound treatment 8.1806864E7 -7.49E7 -1.96 8.5585211E7 -7.3E7 -2.06 -2.841 -0.9997 2141551 PK04_098059 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C20 compound treatment 1.40634549E8 -1.6E7 -0.42 1.33531573E8 -2.51E7 -0.71 -0.7967 -0.9689 2144941 PK04_098060 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C21 compound treatment 1.19296986E8 -3.74E7 -0.98 1.18297934E8 -4.03E7 -1.14 -1.4952 -0.9972 2141535 PK04_098061 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C22 compound treatment 9.4441991E7 -6.22E7 -1.63 9.9830547E7 -5.88E7 -1.66 -2.3233 -1.0 2142185 PK04_098062 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C23 compound treatment 1.79363748E8 2.27E7 0.59 1.78081299E8 1.95E7 0.55 0.8079 0.9992 2141425 PK04_098063 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 C24 compound treatment 1.90829957E8 3.42E7 0.89 1.88038753E8 2.94E7 0.83 1.2185 0.9993 2144353 PK04_098064 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D01 compound treatment 1.55485238E8 -1180000.0 -0.03 1.59186497E8 560000.0 0.02 -0.0106 -0.3072 2143317 PK04_098065 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D02 compound treatment 9.0705369E7 -6.6E7 -1.73 8.9205275E7 -6.94E7 -1.96 -2.6042 -0.9981 2144805 PK04_098066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D03 compound treatment 1.63582088E8 6920000.0 0.18 1.67995909E8 9370000.0 0.26 0.3148 0.9831 2142937 PK04_098067 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D04 compound treatment 1.46113975E8 -1.05E7 -0.28 1.60663197E8 2040000.0 0.06 -0.1547 -0.5484 2141997 PK04_098068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D05 compound treatment 1.16916491E8 -3.97E7 -1.04 1.16683903E8 -4.19E7 -1.18 -1.5715 -0.998 2144781 PK04_098069 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D06 compound treatment 5.3854879E7 -1.03E8 -2.69 5.4707585E7 -1.04E8 -2.93 -3.9737 -0.9991 2144025 PK04_098070 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D07 compound treatment 1.11934611E8 -4.47E7 -1.17 1.10524124E8 -4.81E7 -1.36 -1.7864 -0.9973 2144817 PK04_098071 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D08 compound treatment 1.19960784E8 -3.67E7 -0.96 1.22259602E8 -3.64E7 -1.02 -1.404 -0.9995 2144197 PK04_098072 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D09 compound treatment 1.1024239E8 -4.64E7 -1.22 1.17821105E8 -4.08E7 -1.15 -1.6723 -0.9996 2144761 PK04_098073 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D10 compound treatment 4.2076571E7 -1.15E8 -3.0 4.2982459E7 -1.16E8 -3.26 -4.4254 -0.9991 2142125 PK04_098074 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D11 mock treatment 1.30714888E8 -2.59E7 -0.68 1.41228216E8 -1.74E7 -0.49 -0.827 -0.9872 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D12 mock treatment 1.41710337E8 -1.5E7 -0.39 1.48163205E8 -1.05E7 -0.29 -0.4853 -0.9903 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D13 compound treatment 1.20816135E8 -3.58E7 -0.94 1.28187017E8 -3.04E7 -0.86 -1.2701 -0.999 2143225 PK04_098075 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D14 compound treatment 1.27331122E8 -2.93E7 -0.77 1.3608151E8 -2.25E7 -0.64 -0.9922 -0.9956 2144233 PK04_098076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D15 mock treatment 1.31121429E8 -2.55E7 -0.67 1.3260685E8 -2.6E7 -0.73 -0.9912 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D16 mock treatment 1.48640247E8 -8020000.0 -0.21 1.42669172E8 -1.6E7 -0.45 -0.4665 -0.9399 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D17 compound treatment 1.29718121E8 -2.69E7 -0.71 1.27633745E8 -3.1E7 -0.87 -1.1163 -0.9944 2143045 PK04_098077 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D18 compound treatment 1.50395479E8 -6270000.0 -0.16 1.48007785E8 -1.06E7 -0.3 -0.3276 -0.96 2142013 PK04_098078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D19 compound treatment 1.30888095E8 -2.58E7 -0.67 1.36453909E8 -2.22E7 -0.62 -0.9189 -0.9993 2142213 PK04_098079 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D20 compound treatment 1.52808383E8 -3850000.0 -0.1 1.48371612E8 -1.03E7 -0.29 -0.2757 -0.9007 2141447 PK04_098080 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D21 compound treatment 1.05599505E8 -5.11E7 -1.34 1.0837424E8 -5.03E7 -1.42 -1.9465 -0.9996 2143393 PK04_098081 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D22 compound treatment 1.58813299E8 2150000.0 0.06 1.64537075E8 5910000.0 0.17 0.1576 0.8963 2065844 PK04_098082 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D23 compound treatment 1.30995877E8 -2.57E7 -0.67 1.33699674E8 -2.49E7 -0.7 -0.9718 -0.9998 2144185 PK04_098083 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 D24 compound treatment 1.46108982E8 -1.06E7 -0.28 1.50124481E8 -8500000.0 -0.24 -0.3648 -0.9975 2141197 PK04_098084 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E01 mock treatment 1.9102054E8 3.44E7 0.9 1.87071668E8 2.84E7 0.8 1.2028 0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E02 mock treatment 1.84262616E8 2.76E7 0.72 1.89980331E8 3.14E7 0.88 1.1356 0.995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E03 compound treatment 1.19402287E8 -3.73E7 -0.98 1.27227326E8 -3.14E7 -0.88 -1.3154 -0.9988 2141526 PK04_098085 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E04 compound treatment 1.64522572E8 7860000.0 0.21 1.70789547E8 1.22E7 0.34 0.3879 0.9702 2142637 PK04_098086 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E05 compound treatment 1.57189655E8 527000.0 0.01 1.69530076E8 1.09E7 0.31 0.227 0.7381 2141181 PK04_098087 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E06 compound treatment 1.20592853E8 -3.61E7 -0.94 1.25124476E8 -3.35E7 -0.94 -1.3352 -1.0 2142777 PK04_098088 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E07 compound treatment 1.43554825E8 -1.31E7 -0.34 1.54783083E8 -3840000.0 -0.11 -0.3192 -0.8872 2141090 PK04_098089 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E08 compound treatment 1.28023084E8 -2.86E7 -0.75 1.30777322E8 -2.78E7 -0.78 -1.0851 -0.9997 2144801 PK04_098090 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E09 mock treatment 1.44382875E8 -1.23E7 -0.32 1.59578168E8 951000.0 0.03 -0.2083 -0.6459 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E10 mock treatment 1.49293053E8 -7370000.0 -0.19 1.55342204E8 -3280000.0 -0.09 -0.2019 -0.9434 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E11 compound treatment 1.27183001E8 -2.95E7 -0.77 1.30037411E8 -2.86E7 -0.81 -1.1153 -0.9998 2141328 PK04_098091 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E12 compound treatment 5.5109436E7 -1.02E8 -2.66 5.736263E7 -1.01E8 -2.85 -3.8976 -0.9994 2144117 PK04_098092 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E13 compound treatment 8.7572722E7 -6.91E7 -1.81 8.8799861E7 -6.98E7 -1.97 -2.6702 -0.9991 2141750 PK04_098093 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E14 compound treatment 1.30125431E8 -2.65E7 -0.69 1.31243118E8 -2.74E7 -0.77 -1.0369 -0.9986 2142133 PK04_098094 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E15 compound treatment 8.9319456E7 -6.73E7 -1.76 7.972311E7 -7.89E7 -2.22 -2.8188 -0.9934 2141837 PK04_098095 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E16 compound treatment 1.4302056E8 -1.36E7 -0.36 1.38180707E8 -2.04E7 -0.58 -0.6599 -0.9735 2143333 PK04_098096 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E17 mock treatment 1.5383424E8 -2830000.0 -0.07 1.46660231E8 -1.2E7 -0.34 -0.2908 -0.8423 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E18 mock treatment 1.6228526E8 5620000.0 0.15 1.54976069E8 -3650000.0 -0.1 0.0313 0.1745 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E19 compound treatment 5.462425E7 -1.02E8 -2.67 4.8256709E7 -1.1E8 -3.11 -4.088 -0.9971 2141392 PK04_098097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E20 compound treatment 1.52281436E8 -4380000.0 -0.11 1.45303573E8 -1.33E7 -0.38 -0.3466 -0.8828 2144457 PK04_098098 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E21 compound treatment 1.68096539E8 1.14E7 0.3 1.67883265E8 9260000.0 0.26 0.3961 0.9977 2141783 PK04_098099 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E22 compound treatment 1.67891491E8 1.12E7 0.29 1.60281036E8 1650000.0 0.05 0.2408 0.8091 2142073 PK04_098100 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E23 compound treatment 1.2434436E8 -3.23E7 -0.85 1.20998703E8 -3.76E7 -1.06 -1.348 -0.9937 2141929 PK04_098101 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 E24 compound treatment 2.03704558E8 4.7E7 1.23 2.01665138E8 4.3E7 1.21 1.7283 1.0 2141993 PK04_098102 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F01 mock treatment 1.93723209E8 3.71E7 0.97 1.87999409E8 2.94E7 0.83 1.2713 0.9969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F02 mock treatment 1.76367027E8 1.97E7 0.52 1.81253491E8 2.26E7 0.64 0.8156 0.9945 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F03 compound treatment 1.15082828E8 -4.16E7 -1.09 1.12280719E8 -4.63E7 -1.31 -1.6931 -0.9959 2142917 PK04_098103 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F04 compound treatment 1.63500045E8 6840000.0 0.18 1.68830023E8 1.02E7 0.29 0.3299 0.974 2142953 PK04_098104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F05 compound treatment 1.15264037E8 -4.14E7 -1.08 1.1970923E8 -3.89E7 -1.1 -1.5418 -1.0 2144897 PK04_098105 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F06 compound treatment 1.56720076E8 57500.0 0.0 1.58634626E8 7950.0 0.0 0.0012 0.8035 2144329 PK04_098106 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F07 compound treatment 1.03135085E8 -5.35E7 -1.4 1.08394395E8 -5.02E7 -1.42 -1.9917 -1.0 2144721 PK04_098107 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F08 compound treatment 1.31373017E8 -2.53E7 -0.66 1.38249495E8 -2.04E7 -0.57 -0.8742 -0.9975 2143969 PK04_098108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F09 mock treatment 1.47984037E8 -8680000.0 -0.23 1.54845653E8 -3780000.0 -0.11 -0.236 -0.9405 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F10 mock treatment 1.34804393E8 -2.19E7 -0.57 1.48623552E8 -1.0E7 -0.28 -0.6039 -0.9468 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F11 compound treatment 1.45881146E8 -1.08E7 -0.28 1.51376358E8 -7250000.0 -0.2 -0.344 -0.9874 2141973 PK04_098109 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F12 compound treatment 1.4570237E8 -1.1E7 -0.29 1.52147957E8 -6480000.0 -0.18 -0.332 -0.9762 2141515 PK04_098110 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F13 compound treatment 1.02854278E8 -5.38E7 -1.41 1.14732082E8 -4.39E7 -1.24 -1.8706 -0.9979 2144053 PK04_098111 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F14 compound treatment 1.38815126E8 -1.78E7 -0.47 1.40528054E8 -1.81E7 -0.51 -0.691 -0.999 2143249 PK04_098112 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F15 compound treatment 5.5339682E7 -1.01E8 -2.65 5.8600204E7 -1.0E8 -2.82 -3.8686 -0.9995 2144873 PK04_098113 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F16 compound treatment 1.1644931E8 -4.02E7 -1.05 1.2102815E8 -3.76E7 -1.06 -1.4935 -1.0 2141199 PK04_098114 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F17 mock treatment 1.52613327E8 -4050000.0 -0.11 1.44272088E8 -1.44E7 -0.4 -0.361 -0.8632 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F18 mock treatment 1.57970703E8 1310000.0 0.03 1.49450589E8 -9180000.0 -0.26 -0.1586 -0.6082 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F19 compound treatment 6.4869799E7 -9.18E7 -2.4 6.3763698E7 -9.49E7 -2.67 -3.5894 -0.9986 2142825 PK04_098115 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F20 compound treatment 1.65640289E8 8980000.0 0.24 1.59056384E8 430000.0 0.01 0.1747 0.7426 2144217 PK04_098116 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F21 compound treatment 1.05357508E8 -5.13E7 -1.34 1.05696962E8 -5.29E7 -1.49 -2.0044 -0.9986 2144057 PK04_098117 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F22 compound treatment 1.65655807E8 8990000.0 0.24 1.59661614E8 1030000.0 0.03 0.1871 0.7887 2141689 PK04_098118 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F23 compound treatment 8.7390882E7 -6.93E7 -1.81 8.4649013E7 -7.4E7 -2.08 -2.7563 -0.9976 2144037 PK04_098119 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 F24 compound treatment 2.01820823E8 4.52E7 1.18 1.9417133E8 3.55E7 1.0 1.5442 0.9966 2141464 PK04_098120 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G01 compound treatment 3.9932591E7 -1.17E8 -3.06 4.439603E7 -1.14E8 -3.22 -4.4369 -0.9997 2141573 PK04_098121 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G02 compound treatment 1.32707273E8 -2.4E7 -0.63 1.3281853E8 -2.58E7 -0.73 -0.9577 -0.9973 2144113 PK04_098122 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G03 mock treatment 1.75901801E8 1.92E7 0.5 1.81032412E8 2.24E7 0.63 0.8026 0.9937 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G04 mock treatment 1.69885117E8 1.32E7 0.35 1.7355684E8 1.49E7 0.42 0.5423 0.9953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G05 compound treatment 1.67799927E8 1.11E7 0.29 1.75152485E8 1.65E7 0.47 0.5355 0.9746 2141531 PK04_098123 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G06 compound treatment 1.44623372E8 -1.2E7 -0.32 1.54582795E8 -4040000.0 -0.11 -0.3034 -0.9054 2143985 PK04_098124 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G07 compound treatment 1.46674075E8 -9990000.0 -0.26 1.53139537E8 -5490000.0 -0.15 -0.2942 -0.9686 2065843 PK04_098125 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G08 compound treatment 6.2603382E7 -9.41E7 -2.46 6.2724451E7 -9.59E7 -2.7 -3.652 -0.9989 2144713 PK04_098126 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G09 compound treatment 1.5850352E8 1840000.0 0.05 1.66188919E8 7560000.0 0.21 0.1848 0.8457 2141779 PK04_098127 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G10 compound treatment 1.56561592E8 -101000.0 0.0 1.6032525E8 1700000.0 0.05 0.032 0.667 2142633 PK04_098128 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G11 compound treatment 3.7785613E7 -1.19E8 -3.11 3.8906194E7 -1.2E8 -3.37 -4.586 -0.9992 2141711 PK04_098129 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G12 compound treatment 1.15130173E8 -4.15E7 -1.09 1.28808178E8 -2.98E7 -0.84 -1.3629 -0.9919 2142689 PK04_098130 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G13 compound treatment 1.54863948E8 -1800000.0 -0.05 1.58189205E8 -437000.0 -0.01 -0.042 -0.8632 2141802 PK04_098131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G14 compound treatment 1.13060371E8 -4.36E7 -1.14 1.1301524E8 -4.56E7 -1.29 -1.7159 -0.9982 2142905 PK04_098132 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G15 compound treatment 1.4585602E8 -1.08E7 -0.28 1.53185006E8 -5440000.0 -0.15 -0.3085 -0.9586 2141192 PK04_098133 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G16 compound treatment 1.1842832E8 -3.82E7 -1.0 1.17613691E8 -4.1E7 -1.16 -1.525 -0.9974 2142129 PK04_098134 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G17 compound treatment 5.1858372E7 -1.05E8 -2.74 5.2889904E7 -1.06E8 -2.98 -4.0469 -0.9991 2141728 PK04_098135 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G18 compound treatment 1.36524126E8 -2.01E7 -0.53 1.29304235E8 -2.93E7 -0.83 -0.9571 -0.9764 2144641 PK04_098136 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G19 mock treatment 1.68699325E8 1.2E7 0.32 1.59695757E8 1070000.0 0.03 0.2441 0.7712 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G20 mock treatment 1.66402358E8 9740000.0 0.25 1.63173475E8 4550000.0 0.13 0.2709 0.9493 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G21 compound treatment 1.43819936E8 -1.28E7 -0.34 1.41178587E8 -1.74E7 -0.49 -0.5854 -0.9828 2141885 PK04_098137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G22 compound treatment 1.77046802E8 2.04E7 0.53 1.72464942E8 1.38E7 0.39 0.6531 0.9881 2144357 PK04_098138 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G23 compound treatment 1.72702112E8 1.6E7 0.42 1.69384466E8 1.08E7 0.3 0.5113 0.9872 2141361 PK04_098139 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 G24 compound treatment 2.06594136E8 4.99E7 1.31 2.07928311E8 4.93E7 1.39 1.9066 0.9995 2142625 PK04_098140 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H01 compound treatment 1.64964163E8 8300000.0 0.22 1.61847305E8 3220000.0 0.09 0.2178 0.925 2142737 PK04_098141 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H02 compound treatment 1.46474176E8 -1.02E7 -0.27 1.42075211E8 -1.66E7 -0.47 -0.5184 -0.9648 2144017 PK04_098142 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H03 mock treatment 1.74931656E8 1.83E7 0.48 1.77152294E8 1.85E7 0.52 0.7073 0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H04 mock treatment 1.63777997E8 7120000.0 0.19 1.71872597E8 1.32E7 0.37 0.3957 0.9484 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H05 compound treatment 1.36627683E8 -2.0E7 -0.52 1.4414787E8 -1.45E7 -0.41 -0.6594 -0.9923 2143493 PK04_098143 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H06 compound treatment 1.52558757E8 -4100000.0 -0.11 1.51374936E8 -7250000.0 -0.2 -0.2205 -0.9549 2141857 PK04_098144 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H07 compound treatment 1.51318753E8 -5340000.0 -0.14 1.57307354E8 -1320000.0 -0.04 -0.1252 -0.865 2143497 PK04_098145 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H08 compound treatment 1.47839341E8 -8820000.0 -0.23 1.46358957E8 -1.23E7 -0.35 -0.4078 -0.9808 2141183 PK04_098146 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H09 compound treatment 1.61822772E8 5160000.0 0.14 1.63788567E8 5160000.0 0.15 0.1984 0.9993 2143289 PK04_098147 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H10 compound treatment 1.47614702E8 -9050000.0 -0.24 1.53006876E8 -5620000.0 -0.16 -0.2795 -0.9808 2142033 PK04_098148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H11 compound treatment 1.33520612E8 -2.31E7 -0.61 1.36253938E8 -2.24E7 -0.63 -0.8742 -0.9998 2143345 PK04_098149 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H12 compound treatment 6.4491344E7 -9.22E7 -2.41 6.8335088E7 -9.03E7 -2.54 -3.5053 -0.9996 2141965 PK04_098150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H13 compound treatment 1.44999623E8 -1.17E7 -0.31 1.472396E8 -1.14E7 -0.32 -0.4428 -0.9997 2142053 PK04_098151 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H14 compound treatment 1.52261099E8 -4400000.0 -0.12 1.53500523E8 -5130000.0 -0.14 -0.1836 -0.9937 2143285 PK04_098152 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H15 compound treatment 1.25139406E8 -3.15E7 -0.83 1.25447433E8 -3.32E7 -0.94 -1.2446 -0.9981 2143953 PK04_098153 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H16 compound treatment 1.18034032E8 -3.86E7 -1.01 1.07889439E8 -5.07E7 -1.43 -1.726 -0.9856 2142849 PK04_098154 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H17 compound treatment 1.00496927E8 -5.62E7 -1.47 9.5822825E7 -6.28E7 -1.77 -2.2911 -0.9958 2142197 PK04_098155 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H18 compound treatment 7.6537099E7 -8.01E7 -2.1 7.3805047E7 -8.48E7 -2.39 -3.1733 -0.9979 2141678 PK04_098156 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H19 mock treatment 1.62596959E8 5930000.0 0.16 1.57293657E8 -1330000.0 -0.04 0.0833 0.5211 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H20 mock treatment 1.61262287E8 4600000.0 0.12 1.60658424E8 2030000.0 0.06 0.1256 0.9422 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H21 compound treatment 1.71542137E8 1.49E7 0.39 1.59222004E8 595000.0 0.02 0.2873 0.7369 2142657 PK04_098157 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H22 compound treatment 1.11826754E8 -4.48E7 -1.17 1.13409051E8 -4.52E7 -1.27 -1.7309 -0.9992 2141194 PK04_098158 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H23 compound treatment 1.19191977E8 -3.75E7 -0.98 1.12926823E8 -4.57E7 -1.29 -1.6042 -0.991 2142665 PK04_098159 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 H24 compound treatment 2.07580215E8 5.09E7 1.33 2.03294625E8 4.47E7 1.26 1.8326 0.9996 2141813 PK04_098160 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I01 compound treatment 4.0297069E7 -1.16E8 -3.05 4.4355247E7 -1.14E8 -3.22 -4.4309 -0.9996 2141395 PK04_098161 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I02 compound treatment 1.48553971E8 -8110000.0 -0.21 1.62429201E8 3800000.0 0.11 -0.0743 -0.3126 2144813 PK04_098162 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I03 compound treatment 1.05757578E8 -5.09E7 -1.33 1.1048284E8 -4.81E7 -1.36 -1.9016 -1.0 2141107 PK04_098163 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I04 compound treatment 1.03328297E8 -5.33E7 -1.4 1.05989086E8 -5.26E7 -1.48 -2.0361 -0.9995 2142597 PK04_098164 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I05 mock treatment 1.66155149E8 9490000.0 0.25 1.7255948E8 1.39E7 0.39 0.4533 0.9756 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I06 mock treatment 1.64795012E8 8130000.0 0.21 1.69477824E8 1.09E7 0.31 0.3668 0.9843 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I07 compound treatment 1.64149195E8 7490000.0 0.2 1.73094615E8 1.45E7 0.41 0.4269 0.9436 2141144 PK04_098165 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I08 compound treatment 1.39022883E8 -1.76E7 -0.46 1.45227252E8 -1.34E7 -0.38 -0.5935 -0.995 2142693 PK04_098166 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I09 compound treatment 1.31645941E8 -2.5E7 -0.65 1.40631751E8 -1.8E7 -0.51 -0.8216 -0.992 2141896 PK04_098167 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I10 compound treatment 1.32267641E8 -2.44E7 -0.64 1.37507992E8 -2.11E7 -0.6 -0.8724 -0.9994 2141957 PK04_098168 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I11 compound treatment 1.10792135E8 -4.59E7 -1.2 1.33482087E8 -2.51E7 -0.71 -1.3501 -0.9683 2141394 PK04_098169 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I12 compound treatment 1.4190466E8 -1.48E7 -0.39 1.46059771E8 -1.26E7 -0.35 -0.5236 -0.9991 2142049 PK04_098170 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I13 compound treatment 1.49654301E8 -7010000.0 -0.18 1.61486216E8 2860000.0 0.08 -0.0727 -0.363 2141346 PK04_098171 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I14 compound treatment 7.6380729E7 -8.03E7 -2.1 8.103262E7 -7.76E7 -2.19 -3.0322 -0.9998 2143477 PK04_098172 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I15 compound treatment 3.214046E7 -1.25E8 -3.26 3.3345174E7 -1.25E8 -3.53 -4.8013 -0.9992 2141373 PK04_098173 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I16 compound treatment 1.24650783E8 -3.2E7 -0.84 1.24080821E8 -3.45E7 -0.97 -1.2809 -0.9972 2144645 PK04_098174 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I17 compound treatment 1.59587473E8 2920000.0 0.08 1.5530712E8 -3320000.0 -0.09 -0.012 -0.0993 2141116 PK04_098175 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I18 compound treatment 1.61649806E8 4990000.0 0.13 1.56855467E8 -1770000.0 -0.05 0.057 0.408 2142097 PK04_098176 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I19 compound treatment 1.64493022E8 7830000.0 0.2 1.6074647E8 2120000.0 0.06 0.1872 0.8767 2141442 PK04_098177 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I20 compound treatment 1.7450203E8 1.78E7 0.47 1.7001489E8 1.14E7 0.32 0.5571 0.9832 2142005 PK04_098178 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I21 mock treatment 1.80649279E8 2.4E7 0.63 1.70209919E8 1.16E7 0.33 0.6748 0.9536 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I22 mock treatment 1.80335054E8 2.37E7 0.62 1.77324889E8 1.87E7 0.53 0.8108 0.9967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I23 compound treatment 1.4534063E8 -1.13E7 -0.3 1.43322681E8 -1.53E7 -0.43 -0.5145 -0.9832 2141137 PK04_098179 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 I24 compound treatment 1.71821249E8 1.52E7 0.4 1.57782058E8 -845000.0 -0.02 0.2638 0.6635 2144905 PK04_098180 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J01 compound treatment 1.28448719E8 -2.82E7 -0.74 1.33891792E8 -2.47E7 -0.7 -1.0151 -0.9996 2142853 PK04_098181 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J02 compound treatment 1.87628349E8 3.1E7 0.81 1.80783034E8 2.22E7 0.62 1.0147 0.9917 2141434 PK04_098182 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J03 compound treatment 8.6866951E7 -6.98E7 -1.83 9.2731603E7 -6.59E7 -1.86 -2.605 -1.0 2142925 PK04_098183 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J04 compound treatment 1.33940475E8 -2.27E7 -0.59 1.4292137E8 -1.57E7 -0.44 -0.7335 -0.9894 2141810 PK04_098184 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J05 mock treatment 1.55677573E8 -985000.0 -0.03 1.66658631E8 8030000.0 0.23 0.1418 0.6225 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J06 mock treatment 1.54423135E8 -2240000.0 -0.06 1.61012586E8 2390000.0 0.07 0.0061 0.0683 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J07 compound treatment 1.41618903E8 -1.5E7 -0.39 1.4954262E8 -9080000.0 -0.26 -0.4595 -0.9782 2143253 PK04_098185 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J08 compound treatment 7.9288787E7 -7.74E7 -2.03 7.8708264E7 -7.99E7 -2.25 -3.0247 -0.9986 2141219 PK04_098186 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J09 compound treatment 1.55460436E8 -1200000.0 -0.03 1.58611573E8 -15100.0 0.0 -0.0226 -0.7166 2142945 PK04_098187 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J10 compound treatment 1.46901755E8 -9760000.0 -0.26 1.53860369E8 -4770000.0 -0.13 -0.2756 -0.9549 2141450 PK04_098188 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J11 compound treatment 1.56663729E8 1140.0 0.0 1.5527928E8 -3350000.0 -0.09 -0.0667 -0.7069 2144285 PK04_098189 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J12 compound treatment 9.5197178E7 -6.15E7 -1.61 7.2791101E7 -8.58E7 -2.42 -2.8481 -0.9804 2141139 PK04_098190 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J13 compound treatment 1.24304013E8 -3.24E7 -0.85 1.36967722E8 -2.17E7 -0.61 -1.0305 -0.9871 2143473 PK04_098191 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J14 compound treatment 1.41786312E8 -1.49E7 -0.39 1.39635041E8 -1.9E7 -0.54 -0.6538 -0.9878 2144013 PK04_098192 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J15 compound treatment 4.9499159E7 -1.07E8 -2.81 4.9722969E7 -1.09E8 -3.07 -4.1536 -0.999 2142837 PK04_098193 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J16 compound treatment 1.51348675E8 -5310000.0 -0.14 1.49947498E8 -8680000.0 -0.24 -0.2713 -0.9642 2141784 PK04_098194 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J17 compound treatment 1.21490329E8 -3.52E7 -0.92 1.14439656E8 -4.42E7 -1.25 -1.5315 -0.989 2144425 PK04_098195 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J18 compound treatment 1.12462927E8 -4.42E7 -1.16 1.14255872E8 -4.44E7 -1.25 -1.7023 -0.9992 2141332 PK04_098196 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J19 compound treatment 1.35731511E8 -2.09E7 -0.55 1.38370226E8 -2.03E7 -0.57 -0.7911 -0.9998 2143957 PK04_098197 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J20 compound treatment 1.70008824E8 1.33E7 0.35 1.62412644E8 3790000.0 0.11 0.3225 0.8828 2141933 PK04_098198 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J21 mock treatment 1.67145557E8 1.05E7 0.27 1.62500393E8 3870000.0 0.11 0.2712 0.9184 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J22 mock treatment 1.78761018E8 2.21E7 0.58 1.63569033E8 4940000.0 0.14 0.5075 0.853 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J23 compound treatment 9.4788246E7 -6.19E7 -1.62 8.9932028E7 -6.87E7 -1.94 -2.5141 -0.9961 2144049 PK04_098199 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 J24 compound treatment 1.59684055E8 3020000.0 0.08 1.4790261E8 -1.07E7 -0.3 -0.1578 -0.505 2141196 PK04_098200 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K01 compound treatment 1.88125406E8 3.15E7 0.82 1.96764539E8 3.81E7 1.07 1.3423 0.9914 2141522 PK04_098201 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K02 compound treatment 1.55405453E8 -1260000.0 -0.03 1.5993467E8 1310000.0 0.04 0.0028 0.0566 2142617 PK04_098202 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K03 compound treatment 1.58376056E8 1710000.0 0.04 1.64447433E8 5820000.0 0.16 0.1477 0.8686 2141439 PK04_098203 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K04 compound treatment 1.54899489E8 -1760000.0 -0.05 1.68193481E8 9570000.0 0.27 0.158 0.5777 2143329 PK04_098204 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K05 compound treatment 3.1067162E7 -1.26E8 -3.29 2.9246857E7 -1.29E8 -3.65 -4.9028 -0.9987 2141725 PK04_098205 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K06 compound treatment 1.54774726E8 -1890000.0 -0.05 1.60661832E8 2040000.0 0.06 0.0056 0.0741 2142973 PK04_098206 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K07 mock treatment 1.53500454E8 -3160000.0 -0.08 1.57016337E8 -1610000.0 -0.05 -0.0906 -0.96 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K08 mock treatment 1.49646902E8 -7020000.0 -0.18 1.66153602E8 7530000.0 0.21 0.0201 0.0717 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K09 compound treatment 1.41778142E8 -1.49E7 -0.39 1.47128427E8 -1.15E7 -0.32 -0.5046 -0.9958 2141136 PK04_098207 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K10 compound treatment 1.44298041E8 -1.24E7 -0.32 1.54732122E8 -3890000.0 -0.11 -0.3065 -0.8967 2143005 PK04_098208 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K11 compound treatment 5.185181E7 -1.05E8 -2.74 6.6793954E7 -9.18E7 -2.59 -3.7699 -0.9996 2141925 PK04_098209 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K12 compound treatment 1.26519845E8 -3.01E7 -0.79 1.24775999E8 -3.39E7 -0.95 -1.2325 -0.9956 2144741 PK04_098210 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K13 compound treatment 1.50503196E8 -6160000.0 -0.16 1.55675508E8 -2950000.0 -0.08 -0.1728 -0.9526 2141147 PK04_098211 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K14 compound treatment 9.4234497E7 -6.24E7 -1.63 9.7738779E7 -6.09E7 -1.72 -2.3688 -0.9997 2143465 PK04_098212 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K15 mock treatment 1.56716441E8 53800.0 0.0 1.56436555E8 -2190000.0 -0.06 -0.0426 -0.6908 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K16 mock treatment 1.62066397E8 5400000.0 0.14 1.60262776E8 1640000.0 0.05 0.1326 0.8914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K17 compound treatment 1.58046286E8 1380000.0 0.04 1.56872495E8 -1750000.0 -0.05 -0.0093 -0.1525 2141530 PK04_098213 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K18 compound treatment 1.59435551E8 2770000.0 0.07 1.49811552E8 -8820000.0 -0.25 -0.1243 -0.4804 2143169 PK04_098214 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K19 compound treatment 1.23244587E8 -3.34E7 -0.87 1.13524191E8 -4.51E7 -1.27 -1.5173 -0.9834 2141707 PK04_098215 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K20 compound treatment 1.71447624E8 1.48E7 0.39 1.69026376E8 1.04E7 0.29 0.4809 0.9906 2143073 PK04_098216 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K21 compound treatment 1.82776869E8 2.61E7 0.68 1.73543586E8 1.49E7 0.42 0.7806 0.9727 2141428 PK04_098217 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K22 compound treatment 4.4567872E7 -1.12E8 -2.93 5.1656383E7 -1.07E8 -3.01 -4.2064 -0.9999 2142725 PK04_098218 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K23 mock treatment 1.914726E8 3.48E7 0.91 1.77671456E8 1.9E7 0.54 1.0238 0.9681 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 K24 mock treatment 2.16594566E8 5.99E7 1.57 2.012107E8 4.26E7 1.2 1.9579 0.9912 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L01 compound treatment 1.65455182E8 8790000.0 0.23 1.71054878E8 1.24E7 0.35 0.4104 0.9793 2143889 PK04_098219 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L02 compound treatment 1.12744007E8 -4.39E7 -1.15 1.21060444E8 -3.76E7 -1.06 -1.5615 -0.9992 2141700 PK04_098220 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L03 compound treatment 1.62150755E8 5490000.0 0.14 1.64692041E8 6070000.0 0.17 0.2224 0.9963 2142733 PK04_098221 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L04 compound treatment 1.25428304E8 -3.12E7 -0.82 1.23806135E8 -3.48E7 -0.98 -1.272 -0.9959 2141934 PK04_098222 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L05 compound treatment 1.50146414E8 -6520000.0 -0.17 1.59435984E8 809000.0 0.02 -0.1045 -0.6072 2143873 PK04_098223 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L06 compound treatment 1.49956972E8 -6710000.0 -0.18 1.60878898E8 2250000.0 0.06 -0.0792 -0.4245 2141797 PK04_098224 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L07 mock treatment 1.54225394E8 -2440000.0 -0.06 1.57211306E8 -1420000.0 -0.04 -0.0733 -0.9744 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L08 mock treatment 1.45028472E8 -1.16E7 -0.3 1.5834676E8 -280000.0 -0.01 -0.2209 -0.7252 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L09 compound treatment 1.49545467E8 -7120000.0 -0.19 1.58643445E8 16800.0 0.0 -0.1314 -0.7053 2142957 PK04_098225 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L10 compound treatment 1.43322454E8 -1.33E7 -0.35 1.4614843E8 -1.25E7 -0.35 -0.4956 -1.0 3413983 PK04_098226 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L11 compound treatment 3.3461557E7 -1.23E8 -3.23 3.595948E7 -1.23E8 -3.46 -4.7248 -0.9994 2142717 PK04_098227 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L12 compound treatment 1.3851729E8 -1.81E7 -0.47 1.39861882E8 -1.88E7 -0.53 -0.7098 -0.9986 3413985 PK04_098228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L13 compound treatment 1.40693195E8 -1.6E7 -0.42 1.48713162E8 -9910000.0 -0.28 -0.4931 -0.9808 2143357 PK04_098229 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L14 compound treatment 1.28357828E8 -2.83E7 -0.74 1.38245471E8 -2.04E7 -0.57 -0.93 -0.9921 3413987 PK04_098230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L15 mock treatment 1.42741034E8 -1.39E7 -0.36 1.5141638E8 -7210000.0 -0.2 -0.4014 -0.9619 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L16 mock treatment 1.4202059E8 -1.46E7 -0.38 1.49422129E8 -9200000.0 -0.26 -0.4544 -0.9819 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L17 compound treatment 1.51208269E8 -5450000.0 -0.14 1.59901728E8 1280000.0 0.04 -0.0756 -0.5132 2143089 PK04_098231 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L18 compound treatment 1.41180502E8 -1.55E7 -0.41 1.39112799E8 -1.95E7 -0.55 -0.6754 -0.9887 3413990 PK04_098232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L19 compound treatment 1.25498941E8 -3.12E7 -0.82 1.30504582E8 -2.81E7 -0.79 -1.1372 -0.9999 2144137 PK04_098233 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L20 compound treatment 1.53215724E8 -3450000.0 -0.09 1.49317364E8 -9310000.0 -0.26 -0.2493 -0.8986 3413992 PK04_098234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L21 compound treatment 1.65349476E8 8690000.0 0.23 1.63598241E8 4970000.0 0.14 0.2599 0.9729 2143369 PK04_098235 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L22 compound treatment 1.41233425E8 -1.54E7 -0.4 1.36049229E8 -2.26E7 -0.64 -0.7355 -0.9759 3413998 PK04_098236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5cccc(Br)c5)C/C=C/C[C@@H](Cc6cccc(Br)c6)C(=O)O[C@@H]14 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L23 mock treatment 1.88954566E8 3.23E7 0.85 1.79530266E8 2.09E7 0.59 1.0143 0.9844 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 L24 mock treatment 2.07725455E8 5.11E7 1.34 1.96576692E8 3.8E7 1.07 1.7014 0.9939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M01 compound treatment 2.08013752E8 5.14E7 1.34 2.11088418E8 5.25E7 1.48 1.9959 0.9989 2141977 PK04_098237 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M02 compound treatment 1.74200492E8 1.75E7 0.46 1.71095237E8 1.25E7 0.35 0.5731 0.9913 2144277 PK04_098238 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M03 compound treatment 1.47260373E8 -9400000.0 -0.25 1.44375245E8 -1.43E7 -0.4 -0.458 -0.9724 2143353 PK04_098239 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M04 compound treatment 1.06488686E8 -5.02E7 -1.31 1.08155836E8 -5.05E7 -1.42 -1.9344 -0.9992 2142753 PK04_098240 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M05 compound treatment 1.58008229E8 1350000.0 0.04 1.62982007E8 4360000.0 0.12 0.1117 0.8747 2142713 PK04_098241 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M06 compound treatment 1.41209826E8 -1.55E7 -0.4 1.44109339E8 -1.45E7 -0.41 -0.5753 -1.0 2143893 PK04_098242 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M07 compound treatment 1.42170923E8 -1.45E7 -0.38 1.44453375E8 -1.42E7 -0.4 -0.5507 -0.9997 2143173 PK04_098243 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M08 compound treatment 1.57033024E8 370000.0 0.01 1.58889083E8 262000.0 0.01 0.0121 0.9911 2143913 PK04_098244 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M09 mock treatment 1.52327602E8 -4330000.0 -0.11 1.61945004E8 3320000.0 0.09 -0.0141 -0.096 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M10 mock treatment 1.44822751E8 -1.18E7 -0.31 1.55684723E8 -2940000.0 -0.08 -0.2778 -0.8658 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M11 compound treatment 8.4805176E7 -7.19E7 -1.88 6.8871503E7 -8.98E7 -2.53 -3.1186 -0.9894 2143965 PK04_098245 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M12 compound treatment 1.39468128E8 -1.72E7 -0.45 1.45314555E8 -1.33E7 -0.38 -0.5835 -0.9959 2144453 PK04_098246 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M13 mock treatment 1.50262562E8 -6400000.0 -0.17 1.52474453E8 -6150000.0 -0.17 -0.2411 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M14 mock treatment 1.55567025E8 -1100000.0 -0.03 1.54294349E8 -4330000.0 -0.12 -0.1066 -0.8501 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M15 compound treatment 1.47187773E8 -9470000.0 -0.25 1.51995556E8 -6630000.0 -0.19 -0.3075 -0.9903 2142065 PK04_098247 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M16 compound treatment 1.51596983E8 -5070000.0 -0.13 1.60635588E8 2010000.0 0.06 -0.0537 -0.3727 2143293 PK04_098248 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M17 compound treatment 1.32938766E8 -2.37E7 -0.62 1.28487122E8 -3.01E7 -0.85 -1.0397 -0.9882 2142857 PK04_098249 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M18 compound treatment 1.54863035E8 -1800000.0 -0.05 1.60474439E8 1850000.0 0.05 0.0035 0.05 2142613 PK04_098250 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M19 compound treatment 1.55890177E8 -772000.0 -0.02 1.59184027E8 557000.0 0.02 -0.0032 -0.1246 2142697 PK04_098251 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M20 compound treatment 1.57467693E8 805000.0 0.02 1.4467385E8 -1.4E7 -0.39 -0.2631 -0.6682 2144821 PK04_098252 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M21 compound treatment 1.92088504E8 3.54E7 0.93 1.84526148E8 2.59E7 0.73 1.1718 0.993 2142965 PK04_098253 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M22 compound treatment 1.51236068E8 -5430000.0 -0.14 1.42339542E8 -1.63E7 -0.46 -0.425 -0.8846 2144777 PK04_098254 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M23 compound treatment 1.92631002E8 3.6E7 0.94 1.8552405E8 2.69E7 0.76 1.2017 0.9942 2141143 PK04_098255 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 M24 compound treatment 2.00916937E8 4.43E7 1.16 1.93006563E8 3.44E7 0.97 1.5042 0.9961 2144937 PK04_098256 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N01 compound treatment 1.46629722E8 -1.0E7 -0.26 1.38665188E8 -2.0E7 -0.56 -0.5835 -0.9399 2144901 PK04_098257 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N02 compound treatment 1.17779349E8 -3.89E7 -1.02 1.16775554E8 -4.19E7 -1.18 -1.5537 -0.9973 3413999 PK04_098258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N03 compound treatment 1.69800956E8 1.31E7 0.34 1.59757312E8 1130000.0 0.03 0.2657 0.7693 2143297 PK04_098259 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N04 compound treatment 7.4006627E7 -8.27E7 -2.16 7.6741508E7 -8.19E7 -2.31 -3.1616 -0.9995 3414005 PK04_098260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N05 compound treatment 1.53505416E8 -3160000.0 -0.08 1.5152594E8 -7100000.0 -0.2 -0.1999 -0.9235 2142017 PK04_098261 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N06 compound treatment 1.50221956E8 -6440000.0 -0.17 1.57413087E8 -1210000.0 -0.03 -0.1434 -0.8336 3188747 PK04_098262 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)CCc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N07 compound treatment 1.46851954E8 -9810000.0 -0.26 1.43234023E8 -1.54E7 -0.43 -0.4883 -0.9687 2143017 PK04_098263 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N08 compound treatment 1.35275119E8 -2.14E7 -0.56 1.38069948E8 -2.06E7 -0.58 -0.8055 -0.9999 3188748 PK04_098264 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N09 mock treatment 1.43377305E8 -1.33E7 -0.35 1.44564804E8 -1.41E7 -0.4 -0.5261 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N10 mock treatment 1.46923389E8 -9740000.0 -0.25 1.51748833E8 -6880000.0 -0.19 -0.3173 -0.9909 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N11 compound treatment 1.47562335E8 -9100000.0 -0.24 1.52531942E8 -6090000.0 -0.17 -0.2899 -0.9871 2144265 PK04_098265 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N12 compound treatment 1.28261679E8 -2.84E7 -0.74 1.2900469E8 -2.96E7 -0.83 -1.116 -0.9983 3069249 PK04_098266 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3c(OC)cccc3OC)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N13 mock treatment 1.33156924E8 -2.35E7 -0.62 1.56947256E8 -1680000.0 -0.05 -0.4686 -0.7593 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N14 mock treatment 1.35720119E8 -2.09E7 -0.55 1.37037535E8 -2.16E7 -0.61 -0.8178 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N15 compound treatment 1.16179947E8 -4.05E7 -1.06 1.11836243E8 -4.68E7 -1.32 -1.6817 -0.9941 2143165 PK04_098267 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N16 compound treatment 1.27644189E8 -2.9E7 -0.76 1.27665935E8 -3.1E7 -0.87 -1.1541 -0.9976 3188751 PK04_098268 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N17 compound treatment 1.39635374E8 -1.7E7 -0.45 1.51626737E8 -7000000.0 -0.2 -0.4547 -0.9328 2144365 PK04_098269 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N18 compound treatment 4.469819E7 -1.12E8 -2.93 4.349334E7 -1.15E8 -3.24 -4.3666 -0.9987 3188752 PK04_098270 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3cccc(F)c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N19 compound treatment 8.7580109E7 -6.91E7 -1.81 8.0500177E7 -7.81E7 -2.2 -2.8355 -0.9952 2142105 PK04_098271 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N20 compound treatment 1.29993693E8 -2.67E7 -0.7 1.26674849E8 -3.2E7 -0.9 -1.1303 -0.9921 3068687 PK04_098272 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(OC)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N21 compound treatment 1.73347855E8 1.67E7 0.44 1.60297609E8 1670000.0 0.05 0.3421 0.7788 2144245 PK04_098273 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N22 compound treatment 4.8227629E7 -1.08E8 -2.84 4.544639E7 -1.13E8 -3.19 -4.2624 -0.9983 3068689 PK04_098274 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N23 compound treatment 1.85308771E8 2.86E7 0.75 1.76132872E8 1.75E7 0.49 0.8791 0.9794 2143153 PK04_098275 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 N24 compound treatment 3.0617778E7 -1.26E8 -3.3 3.0687103E7 -1.28E8 -3.61 -4.8825 -0.999 3188876 PK04_098276 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O01 compound treatment 2.10956196E8 5.43E7 1.42 2.06636249E8 4.8E7 1.35 1.9616 0.9997 2143373 PK04_098277 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O02 compound treatment 1.50869395E8 -5790000.0 -0.15 1.48483915E8 -1.01E7 -0.29 -0.3093 -0.956 2142209 PK04_098278 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O03 compound treatment 1.51453187E8 -5210000.0 -0.14 1.4478213E8 -1.38E7 -0.39 -0.3723 -0.9008 2144345 PK04_098279 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O04 compound treatment 1.38327378E8 -1.83E7 -0.48 1.23261956E8 -3.54E7 -1.0 -1.0441 -0.9439 2142673 PK04_098280 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O05 compound treatment 1.23238328E8 -3.34E7 -0.87 1.17318305E8 -4.13E7 -1.16 -1.4418 -0.9901 2143977 PK04_098281 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O06 compound treatment 1.63523701E8 6860000.0 0.18 1.56764721E8 -1860000.0 -0.05 0.0899 0.4804 2142077 PK04_098282 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O07 compound treatment 1.65943016E8 9280000.0 0.24 1.52096789E8 -6530000.0 -0.18 0.0417 0.1367 2141985 PK04_098283 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O08 compound treatment 5.4830683E7 -1.02E8 -2.67 6.3911185E7 -9.47E7 -2.67 -3.7722 -1.0 2143485 PK04_098284 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O09 compound treatment 1.44848581E8 -1.18E7 -0.31 1.31762567E8 -2.69E7 -0.76 -0.754 -0.922 2144665 PK04_098285 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O10 compound treatment 1.46415261E8 -1.02E7 -0.27 1.39941611E8 -1.87E7 -0.53 -0.562 -0.951 2143273 PK04_098286 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O11 mock treatment 1.56659833E8 -2760.0 0.0 1.47870524E8 -1.08E7 -0.3 -0.2144 -0.7073 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O12 mock treatment 1.66189612E8 9530000.0 0.25 1.43728346E8 -1.49E7 -0.42 -0.1205 -0.2468 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O13 compound treatment 1.51756882E8 -4910000.0 -0.13 1.31327399E8 -2.73E7 -0.77 -0.6348 -0.8139 2144773 PK04_098287 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O14 compound treatment 1.25771947E8 -3.09E7 -0.81 1.08386052E8 -5.02E7 -1.42 -1.5729 -0.9647 2143945 PK04_098288 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O15 compound treatment 1.68455622E8 1.18E7 0.31 1.47002586E8 -1.16E7 -0.33 -0.0133 -0.0296 2144317 PK04_098289 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O16 compound treatment 1.60270621E8 3610000.0 0.09 1.72887855E8 1.43E7 0.4 0.351 0.8501 2143905 PK04_098290 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O17 compound treatment 1.791896E8 2.25E7 0.59 1.82571298E8 2.39E7 0.67 0.8941 0.9977 2143917 PK04_098291 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O18 compound treatment 1.69876939E8 1.32E7 0.35 1.70054309E8 1.14E7 0.32 0.4723 0.9994 2144253 PK04_098292 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O19 compound treatment 7.7417696E7 -7.92E7 -2.07 5.9864496E7 -9.88E7 -2.78 -3.4348 -0.9895 2144105 PK04_098293 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O20 compound treatment 1.655872E8 8920000.0 0.23 1.55074131E8 -3550000.0 -0.1 0.0944 0.3714 2144293 PK04_098294 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O21 compound treatment 1.98096006E8 4.14E7 1.08 1.93844279E8 3.52E7 0.99 1.4687 0.999 2142997 PK04_098295 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O22 compound treatment 1.04666423E8 -5.2E7 -1.36 9.9037515E7 -5.96E7 -1.68 -2.1498 -0.9946 2144737 PK04_098296 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O23 compound treatment 2.0538993E8 4.87E7 1.28 1.99189778E8 4.06E7 1.14 1.7102 0.9985 2141452 PK04_098297 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 O24 compound treatment 1.80657519E8 2.4E7 0.63 1.7075679E8 1.21E7 0.34 0.6859 0.9591 2142677 PK04_098298 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P01 compound treatment 1.21756432E8 -3.49E7 -0.91 1.23876335E8 -3.48E7 -0.98 -1.3386 -0.9994 2144005 PK04_098299 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P02 compound treatment 4.0543534E7 -1.16E8 -3.04 3.4987155E7 -1.24E8 -3.48 -4.613 -0.9977 3068772 PK04_098300 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(C#N)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P03 compound treatment 1.75625301E8 1.9E7 0.5 1.70658835E8 1.2E7 0.34 0.5908 0.9827 2142593 PK04_098301 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P04 compound treatment 1.04430063E8 -5.22E7 -1.37 9.9127225E7 -5.95E7 -1.68 -2.1524 -0.9949 3000699 PK04_098302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P05 compound treatment 1.25314392E8 -3.13E7 -0.82 1.22687283E8 -3.59E7 -1.01 -1.2964 -0.9946 2144921 PK04_098303 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P06 compound treatment 4.8973409E7 -1.08E8 -2.82 4.5226025E7 -1.13E8 -3.2 -4.253 -0.998 3000700 PK04_098304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P07 compound treatment 1.71156242E8 1.45E7 0.38 1.60087206E8 1460000.0 0.04 0.2974 0.7792 2143937 PK04_098305 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P08 compound treatment 6.8950776E7 -8.77E7 -2.3 5.5979606E7 -1.03E8 -2.89 -3.6689 -0.9935 3000701 PK04_098306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P09 compound treatment 1.57612284E8 950000.0 0.02 1.41234543E8 -1.74E7 -0.49 -0.329 -0.6704 2144785 PK04_098307 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P10 compound treatment 1.42374273E8 -1.43E7 -0.37 1.25609838E8 -3.3E7 -0.93 -0.9224 -0.9198 3089322 PK04_098308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P11 mock treatment 1.65289372E8 8630000.0 0.23 1.52470151E8 -6160000.0 -0.17 0.037 0.1299 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P12 mock treatment 1.57480303E8 818000.0 0.02 1.44885574E8 -1.37E7 -0.39 -0.2587 -0.667 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P13 compound treatment 1.60559103E8 3900000.0 0.1 1.46185923E8 -1.24E7 -0.35 -0.1758 -0.4814 2144213 PK04_098309 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P14 compound treatment 9.2833828E7 -6.38E7 -1.67 1.02363537E8 -5.63E7 -1.59 -2.3026 -0.9997 3089323 PK04_098310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P15 compound treatment 1.71035787E8 1.44E7 0.38 1.55651709E8 -2970000.0 -0.08 0.2068 0.5364 2144225 PK04_098311 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P16 compound treatment 1.16910455E8 -3.98E7 -1.04 1.13484517E8 -4.51E7 -1.27 -1.6353 -0.995 3000703 PK04_098312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P17 compound treatment 1.66268247E8 9610000.0 0.25 1.56284627E8 -2340000.0 -0.07 0.1311 0.5044 2141953 PK04_098313 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P18 compound treatment 1.21968728E8 -3.47E7 -0.91 1.4543194E8 -1.32E7 -0.37 -0.9051 -0.9223 3000704 PK04_098314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)c4cc5ccccc5[nH]4)[C@H]1OC(=O)c6cc7ccccc7[nH]6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P19 compound treatment 1.7812378E8 2.15E7 0.56 1.6222479E8 3600000.0 0.1 0.4689 0.8215 2143337 PK04_098315 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P20 compound treatment 1.11637248E8 -4.5E7 -1.18 1.07083665E8 -5.15E7 -1.45 -1.8605 -0.9946 3089326 PK04_098316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P21 compound treatment 1.83201107E8 2.65E7 0.69 1.76239328E8 1.76E7 0.5 0.8422 0.9864 2143233 PK04_098317 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P22 compound treatment 1.10412951E8 -4.62E7 -1.21 1.06770866E8 -5.19E7 -1.46 -1.8894 -0.9956 3089328 PK04_098318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P23 compound treatment 2.14551121E8 5.79E7 1.52 2.05211726E8 4.66E7 1.31 1.9998 0.9974 2142969 PK04_098319 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2098 P24 compound treatment 2.39619833E8 8.3E7 2.17 2.23573026E8 6.49E7 1.83 2.8297 0.9964 3189006 PK04_098320 CC(C)[Si](OCCCNS(=O)(=O)c1ccc(Br)cc1)(C(C)C)C(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A01 compound treatment 1.94367798E8 3.45E7 0.9 2.1931274E8 4.31E7 1.21 1.497 0.9894 3052787 PK04_100001 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A02 compound treatment 1.75725172E8 1.59E7 0.42 2.0439601E8 2.81E7 0.79 0.8547 0.9545 3052649 PK04_100002 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A03 compound treatment 1.72136074E8 1.23E7 0.32 1.96214089E8 2.0E7 0.56 0.6252 0.9648 3176622 PK04_100003 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A04 compound treatment 1.82249544E8 2.24E7 0.59 2.03798378E8 2.75E7 0.78 0.9636 0.9904 3175961 PK04_100004 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A05 compound treatment 1.56521439E8 -3330000.0 -0.09 1.8047405E8 4230000.0 0.12 0.0226 0.153 3176556 PK04_100005 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A06 compound treatment 1.47010253E8 -1.28E7 -0.34 1.92908473E8 1.67E7 0.47 0.0943 0.1633 3176630 PK04_100006 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A07 compound treatment 1.4427963E8 -1.56E7 -0.41 1.70528476E8 -5720000.0 -0.16 -0.4022 -0.9176 3175901 PK04_100007 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A08 compound treatment 1.51831034E8 -8020000.0 -0.21 1.70713584E8 -5530000.0 -0.16 -0.2587 -0.9893 3176729 PK04_100008 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A09 compound treatment 1.20699595E8 -3.92E7 -1.02 1.34785225E8 -4.15E7 -1.17 -1.5509 -0.9979 3052580 PK04_100009 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A10 compound treatment 1.39358296E8 -2.05E7 -0.54 1.6457116E8 -1.17E7 -0.33 -0.612 -0.9725 3176731 PK04_100010 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A11 compound treatment 1.15595005E8 -4.43E7 -1.16 1.33904314E8 -4.23E7 -1.19 -1.6629 -0.9999 3176633 PK04_100011 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A12 compound treatment 1.3406295E8 -2.58E7 -0.68 1.7687827E8 630000.0 0.02 -0.4648 -0.6883 3176445 PK04_100012 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A13 mock treatment 1.52952096E8 -6900000.0 -0.18 1.92656366E8 1.64E7 0.46 0.1993 0.4014 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A14 mock treatment 1.356072E8 -2.42E7 -0.63 1.68890368E8 -7360000.0 -0.21 -0.5954 -0.8918 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A15 compound treatment 1.33317911E8 -2.65E7 -0.69 1.63640855E8 -1.26E7 -0.36 -0.7423 -0.9515 3175963 PK04_100013 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A16 compound treatment 1.65962014E8 6110000.0 0.16 1.93794531E8 1.75E7 0.49 0.4628 0.8904 3052785 PK04_100014 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A17 compound treatment 1.41214999E8 -1.86E7 -0.49 1.70116728E8 -6130000.0 -0.17 -0.4671 -0.9026 3052837 PK04_100015 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A18 compound treatment 1.63713526E8 3860000.0 0.1 1.93217465E8 1.7E7 0.48 0.4096 0.8381 3176262 PK04_100016 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A19 compound treatment 1.59378388E8 -472000.0 -0.01 1.82405019E8 6160000.0 0.17 0.1139 0.6551 3176686 PK04_100017 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A20 compound treatment 1.6945222E8 9600000.0 0.25 1.8409892E8 7850000.0 0.22 0.3342 0.998 3176371 PK04_100018 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A21 compound treatment 1.63454726E8 3600000.0 0.09 1.88757788E8 1.25E7 0.35 0.316 0.8659 3052829 PK04_100019 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A22 compound treatment 1.80747291E8 2.09E7 0.55 2.05038196E8 2.88E7 0.81 0.9605 0.9816 3052833 PK04_100020 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A23 compound treatment 1.81556577E8 2.17E7 0.57 1.98423566E8 2.22E7 0.62 0.8436 0.9989 3052878 PK04_100021 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 A24 compound treatment 2.16414974E8 5.66E7 1.48 2.25433592E8 4.92E7 1.39 2.0271 0.9995 3052694 PK04_100022 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B01 compound treatment 2.00292891E8 4.04E7 1.06 2.20340673E8 4.41E7 1.24 1.6272 0.9968 3052928 PK04_100023 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B02 compound treatment 1.65500176E8 5650000.0 0.15 1.79455523E8 3210000.0 0.09 0.1685 0.9721 3052800 PK04_100024 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B03 compound treatment 1.54929652E8 -4920000.0 -0.13 1.67358027E8 -8890000.0 -0.25 -0.2682 -0.9522 3052842 PK04_100025 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B04 compound treatment 1.49852466E8 -1.0E7 -0.26 1.55487662E8 -2.08E7 -0.59 -0.5988 -0.9342 3176782 PK04_100026 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B05 compound treatment 1.4516908E8 -1.47E7 -0.38 1.83953809E8 7710000.0 0.22 -0.1182 -0.2678 3175971 PK04_100027 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B06 compound treatment 1.45251203E8 -1.46E7 -0.38 1.61274762E8 -1.5E7 -0.42 -0.5686 -0.9988 3176561 PK04_100028 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B07 compound treatment 1.44398412E8 -1.55E7 -0.4 1.77944892E8 1700000.0 0.05 -0.2522 -0.6192 3176369 PK04_100029 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B08 compound treatment 1.44230039E8 -1.56E7 -0.41 1.6958611E8 -6660000.0 -0.19 -0.4219 -0.9377 3176441 PK04_100030 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B09 compound treatment 1.45347741E8 -1.45E7 -0.38 1.69526615E8 -6720000.0 -0.19 -0.4024 -0.9484 3052641 PK04_100031 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B10 compound treatment 1.36219452E8 -2.36E7 -0.62 1.67906512E8 -8340000.0 -0.24 -0.6036 -0.9122 3176555 PK04_100032 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B11 compound treatment 1.31867833E8 -2.8E7 -0.73 1.54309919E8 -2.19E7 -0.62 -0.9551 -0.9964 3176554 PK04_100033 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B12 compound treatment 1.35057227E8 -2.48E7 -0.65 1.6554607E8 -1.07E7 -0.3 -0.6722 -0.9392 3052747 PK04_100034 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B13 mock treatment 1.3148806E8 -2.84E7 -0.74 1.54646326E8 -2.16E7 -0.61 -0.9554 -0.9951 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B14 mock treatment 1.29899024E8 -3.0E7 -0.78 1.53483017E8 -2.28E7 -0.64 -1.008 -0.995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B15 compound treatment 1.18859697E8 -4.1E7 -1.07 1.48321318E8 -2.79E7 -0.79 -1.3152 -0.9884 3052707 PK04_100035 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B16 compound treatment 1.35069802E8 -2.48E7 -0.65 1.50006496E8 -2.62E7 -0.74 -0.9816 -0.9979 3176447 PK04_100036 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B17 compound treatment 1.2816834E8 -3.17E7 -0.83 1.53448889E8 -2.28E7 -0.64 -1.0407 -0.992 3176194 PK04_100037 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B18 compound treatment 1.4431013E8 -1.55E7 -0.41 1.6596243E8 -1.03E7 -0.29 -0.4926 -0.9862 3176504 PK04_100038 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B19 compound treatment 1.44941059E8 -1.49E7 -0.39 1.60453946E8 -1.58E7 -0.45 -0.5907 -0.9979 3176439 PK04_100039 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B20 compound treatment 1.64912665E8 5060000.0 0.13 1.83064657E8 6820000.0 0.19 0.2295 0.9836 3176678 PK04_100040 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B21 compound treatment 1.587515E8 -1100000.0 -0.03 1.73418097E8 -2830000.0 -0.08 -0.0767 -0.9051 3176260 PK04_100041 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B22 compound treatment 1.55986392E8 -3860000.0 -0.1 1.73697779E8 -2550000.0 -0.07 -0.1224 -0.986 3176621 PK04_100042 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B23 compound treatment 1.73056031E8 1.32E7 0.35 1.83691961E8 7440000.0 0.21 0.3928 0.9713 3176370 PK04_100043 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 B24 compound treatment 1.94706698E8 3.49E7 0.91 2.11836888E8 3.56E7 1.0 1.3543 0.9989 3176636 PK04_100044 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C01 compound treatment 1.9057099E8 3.07E7 0.8 2.02228364E8 2.6E7 0.73 1.0863 0.9989 3052532 PK04_100045 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C02 compound treatment 1.63466694E8 3620000.0 0.09 1.80088705E8 3840000.0 0.11 0.1435 0.9978 3052638 PK04_100046 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C03 compound treatment 1.60139041E8 288000.0 0.01 1.73314527E8 -2930000.0 -0.08 -0.0531 -0.6399 3052540 PK04_100047 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCN(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C04 compound treatment 1.56501031E8 -3350000.0 -0.09 1.70714323E8 -5530000.0 -0.16 -0.1723 -0.9629 3052751 PK04_100048 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C05 compound treatment 1.47105714E8 -1.27E7 -0.33 1.7677985E8 531000.0 0.01 -0.2253 -0.6747 3052702 PK04_100049 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C06 compound treatment 1.42990563E8 -1.69E7 -0.44 1.7453887E8 -1710000.0 -0.05 -0.3461 -0.7797 3176680 PK04_100050 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C07 compound treatment 1.46111742E8 -1.37E7 -0.36 1.75092527E8 -1160000.0 -0.03 -0.2773 -0.768 3052743 PK04_100051 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C08 compound treatment 1.40258005E8 -1.96E7 -0.51 1.68501318E8 -7750000.0 -0.22 -0.517 -0.9276 3176043 PK04_100052 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C09 compound treatment 1.53726822E8 -6120000.0 -0.16 1.71335362E8 -4910000.0 -0.14 -0.2112 -0.9973 3052925 PK04_100053 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C10 compound treatment 1.35621005E8 -2.42E7 -0.63 1.57756236E8 -1.85E7 -0.52 -0.817 -0.9952 3176324 PK04_100054 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C11 mock treatment 1.43519717E8 -1.63E7 -0.43 1.8065138E8 4400000.0 0.12 -0.2145 -0.482 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C12 mock treatment 1.35593464E8 -2.43E7 -0.63 1.62502855E8 -1.37E7 -0.39 -0.7229 -0.9719 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C13 compound treatment 1.41185523E8 -1.87E7 -0.49 1.63052677E8 -1.32E7 -0.37 -0.6084 -0.9909 3176376 PK04_100055 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C14 compound treatment 1.24371108E8 -3.55E7 -0.93 1.54004501E8 -2.22E7 -0.63 -1.1 -0.9817 3176324 PK04_100056 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C15 mock treatment 1.32943647E8 -2.69E7 -0.7 1.66052283E8 -1.02E7 -0.29 -0.7012 -0.9218 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C16 mock treatment 1.29888246E8 -3.0E7 -0.78 1.63159229E8 -1.31E7 -0.37 -0.8154 -0.9408 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C17 compound treatment 1.45842576E8 -1.4E7 -0.37 1.69138622E8 -7110000.0 -0.2 -0.401 -0.9596 3052884 PK04_100057 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C18 compound treatment 1.40579571E8 -1.93E7 -0.5 1.66722564E8 -9530000.0 -0.27 -0.5465 -0.9564 3176562 PK04_100058 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C19 compound treatment 1.38663468E8 -2.12E7 -0.55 1.66505701E8 -9740000.0 -0.27 -0.5863 -0.9474 3176124 PK04_100059 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C20 compound treatment 1.45562671E8 -1.43E7 -0.37 1.6730073E8 -8950000.0 -0.25 -0.4428 -0.9816 3052784 PK04_100060 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C21 compound treatment 1.49848138E8 -1.0E7 -0.26 1.74065746E8 -2180000.0 -0.06 -0.2286 -0.8501 3052792 PK04_100061 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C22 compound treatment 1.50521071E8 -9330000.0 -0.24 1.69351774E8 -6900000.0 -0.19 -0.3101 -0.9936 3052749 PK04_100062 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C23 compound treatment 1.64478387E8 4630000.0 0.12 1.75853303E8 -395000.0 -0.01 0.0778 0.6394 3176204 PK04_100063 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 C24 compound treatment 1.82548043E8 2.27E7 0.59 1.81348776E8 5100000.0 0.14 0.5218 0.8535 3176041 PK04_100064 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D01 compound treatment 1.75289043E8 1.54E7 0.4 1.88862345E8 1.26E7 0.36 0.5371 0.998 3052926 PK04_100065 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D02 compound treatment 1.63779708E8 3930000.0 0.1 1.83904028E8 7660000.0 0.22 0.2253 0.9426 3176201 PK04_100066 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D03 compound treatment 1.7137622E8 1.15E7 0.3 1.90089836E8 1.38E7 0.39 0.4891 0.9919 3052885 PK04_100067 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D04 compound treatment 1.43969303E8 -1.59E7 -0.42 1.3949385E8 -3.68E7 -1.04 -1.0264 -0.9196 3176377 PK04_100068 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D05 compound treatment 1.53264189E8 -6590000.0 -0.17 1.6463733E8 -1.16E7 -0.33 -0.3533 -0.9552 3052790 PK04_100069 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D06 compound treatment 1.60844229E8 994000.0 0.03 1.80395516E8 4150000.0 0.12 0.101 0.8438 3052881 PK04_100070 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D07 compound treatment 1.62781134E8 2930000.0 0.08 1.82369159E8 6120000.0 0.17 0.1762 0.9334 3052536 PK04_100071 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D08 compound treatment 1.50618983E8 -9230000.0 -0.24 1.72157677E8 -4090000.0 -0.12 -0.2524 -0.9427 3052923 PK04_100072 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D09 compound treatment 1.42326046E8 -1.75E7 -0.46 1.70862066E8 -5390000.0 -0.15 -0.4317 -0.8934 3052690 PK04_100073 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D10 compound treatment 1.39581022E8 -2.03E7 -0.53 1.62140072E8 -1.41E7 -0.4 -0.6563 -0.9899 3052841 PK04_100074 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D11 mock treatment 1.42132838E8 -1.77E7 -0.46 1.73768417E8 -2480000.0 -0.07 -0.3774 -0.8046 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D12 mock treatment 1.46055507E8 -1.38E7 -0.36 1.73854779E8 -2390000.0 -0.07 -0.303 -0.8249 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D13 compound treatment 1.43497938E8 -1.64E7 -0.43 1.74638397E8 -1610000.0 -0.05 -0.3348 -0.7777 3176624 PK04_100075 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D14 compound treatment 1.24141895E8 -3.57E7 -0.93 1.30262241E8 -4.6E7 -1.3 -1.5773 -0.9871 3176375 PK04_100076 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D15 mock treatment 1.3799058E8 -2.19E7 -0.57 1.69810558E8 -6440000.0 -0.18 -0.5329 -0.8877 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D16 mock treatment 1.44009153E8 -1.58E7 -0.41 1.66551151E8 -9700000.0 -0.27 -0.4865 -0.9795 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D17 compound treatment 1.33894321E8 -2.6E7 -0.68 1.64667556E8 -1.16E7 -0.33 -0.7112 -0.9435 3176503 PK04_100077 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D18 compound treatment 1.44355659E8 -1.55E7 -0.41 1.69767155E8 -6480000.0 -0.18 -0.416 -0.9351 3052543 PK04_100078 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D19 compound treatment 1.3710609E8 -2.27E7 -0.6 1.72762015E8 -3490000.0 -0.1 -0.4905 -0.8128 3052538 PK04_100079 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D20 compound treatment 1.43067436E8 -1.68E7 -0.44 1.72277993E8 -3970000.0 -0.11 -0.3898 -0.8597 3052705 PK04_100080 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D21 compound treatment 1.42510728E8 -1.73E7 -0.45 1.70233184E8 -6020000.0 -0.17 -0.4408 -0.9098 3052691 PK04_100081 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D22 compound treatment 1.51371496E8 -8480000.0 -0.22 1.69358998E8 -6890000.0 -0.19 -0.2942 -0.9978 3052534 PK04_100082 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D23 compound treatment 1.54826292E8 -5020000.0 -0.13 1.67046623E8 -9200000.0 -0.26 -0.2764 -0.9505 3176202 PK04_100083 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 D24 compound treatment 1.79850573E8 2.0E7 0.52 2.03693734E8 2.74E7 0.77 0.9171 0.9819 3176197 PK04_100084 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E01 mock treatment 1.80461325E8 2.06E7 0.54 2.08608794E8 3.24E7 0.91 1.0263 0.9686 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E02 mock treatment 1.83298035E8 2.34E7 0.61 1.95278968E8 1.9E7 0.54 0.8132 0.9977 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E03 compound treatment 1.77127991E8 1.73E7 0.45 1.92782452E8 1.65E7 0.47 0.6493 0.9999 3176672 PK04_100085 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E04 compound treatment 1.66178014E8 6330000.0 0.17 1.88006687E8 1.18E7 0.33 0.3514 0.9486 3052883 PK04_100086 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E05 compound treatment 1.63656463E8 3810000.0 0.1 1.85007856E8 8760000.0 0.25 0.245 0.9204 3176126 PK04_100087 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E06 compound treatment 1.61197738E8 1350000.0 0.04 1.82268349E8 6020000.0 0.17 0.1449 0.8362 3052533 PK04_100088 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E07 compound treatment 1.49481678E8 -1.04E7 -0.27 1.75171752E8 -1080000.0 -0.03 -0.2134 -0.7813 3175839 PK04_100089 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E08 compound treatment 1.57217146E8 -2630000.0 -0.07 1.82068354E8 5820000.0 0.16 0.0672 0.3779 3052695 PK04_100090 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E09 mock treatment 1.57164555E8 -2690000.0 -0.07 1.7848205E8 2230000.0 0.06 -0.0052 -0.0552 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E10 mock treatment 1.48146827E8 -1.17E7 -0.31 1.7912146E8 2870000.0 0.08 -0.1594 -0.503 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E11 compound treatment 1.37294597E8 -2.26E7 -0.59 1.48313544E8 -2.79E7 -0.79 -0.9742 -0.99 3176568 PK04_100091 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E12 compound treatment 1.47833812E8 -1.2E7 -0.31 1.72590189E8 -3660000.0 -0.1 -0.2953 -0.8922 3176044 PK04_100092 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E13 compound treatment 1.46987697E8 -1.29E7 -0.34 1.72685858E8 -3560000.0 -0.1 -0.3091 -0.8797 3052753 PK04_100093 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E14 compound treatment 1.33915859E8 -2.59E7 -0.68 1.69953233E8 -6300000.0 -0.18 -0.6055 -0.8629 3175962 PK04_100094 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E15 compound treatment 1.42603312E8 -1.72E7 -0.45 1.69799324E8 -6450000.0 -0.18 -0.4478 -0.92 3176325 PK04_100095 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E16 compound treatment 1.38286952E8 -2.16E7 -0.56 1.7418277E8 -2070000.0 -0.06 -0.4403 -0.7759 3052542 PK04_100096 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E17 mock treatment 1.41068025E8 -1.88E7 -0.49 1.68736323E8 -7510000.0 -0.21 -0.4974 -0.9291 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E18 mock treatment 1.47698385E8 -1.22E7 -0.32 1.72846213E8 -3400000.0 -0.1 -0.2927 -0.8811 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E19 compound treatment 1.48229226E8 -1.16E7 -0.3 1.60843972E8 -1.54E7 -0.43 -0.5221 -0.9849 3052746 PK04_100097 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E20 compound treatment 1.43619582E8 -1.62E7 -0.42 1.76578868E8 330000.0 0.01 -0.2938 -0.6914 3176676 PK04_100098 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E21 compound treatment 1.44879163E8 -1.5E7 -0.39 1.73180544E8 -3070000.0 -0.09 -0.3383 -0.8428 3052756 PK04_100099 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E22 compound treatment 1.6811806E8 8270000.0 0.22 1.80449445E8 4200000.0 0.12 0.2367 0.9597 3176560 PK04_100100 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E23 compound treatment 1.59683754E8 -167000.0 0.0 1.72657473E8 -3590000.0 -0.1 -0.0746 -0.7369 3052487 PK04_100101 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 E24 compound treatment 1.84306724E8 2.45E7 0.64 1.98826991E8 2.26E7 0.64 0.9026 1.0 3176563 PK04_100102 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F01 mock treatment 1.93015932E8 3.32E7 0.87 2.10992772E8 3.47E7 0.98 1.3062 0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F02 mock treatment 1.81223439E8 2.14E7 0.56 1.9148339E8 1.52E7 0.43 0.6992 0.9914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F03 compound treatment 1.36390074E8 -2.35E7 -0.61 1.42639046E8 -3.36E7 -0.95 -1.104 -0.978 3176684 PK04_100103 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F04 compound treatment 1.65161058E8 5310000.0 0.14 1.79639606E8 3390000.0 0.1 0.1659 0.9833 3176121 PK04_100104 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F05 compound treatment 1.66247217E8 6400000.0 0.17 1.81562709E8 5310000.0 0.15 0.2243 0.9984 3176435 PK04_100105 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F06 compound treatment 1.56901068E8 -2950000.0 -0.08 1.78061744E8 1810000.0 0.05 -0.0185 -0.1994 3176627 PK04_100106 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F07 compound treatment 1.60165243E8 315000.0 0.01 1.82557885E8 6310000.0 0.18 0.1316 0.7391 3176774 PK04_100107 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F08 compound treatment 1.56703064E8 -3150000.0 -0.08 1.76341598E8 93200.0 0.0 -0.0564 -0.6842 3174822 PK04_100108 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F09 mock treatment 1.57769054E8 -2080000.0 -0.05 1.76576305E8 328000.0 0.01 -0.032 -0.5789 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F10 mock treatment 1.45650785E8 -1.42E7 -0.37 1.76125651E8 -123000.0 0.0 -0.2653 -0.7137 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F11 compound treatment 1.50791928E8 -9060000.0 -0.24 1.76486792E8 238000.0 0.01 -0.1629 -0.6868 3176192 PK04_100109 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F12 compound treatment 1.4283063E8 -1.7E7 -0.45 1.71184823E8 -5060000.0 -0.14 -0.4159 -0.8891 3052594 PK04_100110 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F13 compound treatment 1.39673365E8 -2.02E7 -0.53 1.75016045E8 -1230000.0 -0.03 -0.398 -0.752 3052748 PK04_100111 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F14 compound treatment 1.4202761E8 -1.78E7 -0.47 1.63212603E8 -1.3E7 -0.37 -0.5897 -0.993 3176567 PK04_100112 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F15 compound treatment 1.40869411E8 -1.9E7 -0.5 1.72698867E8 -3550000.0 -0.1 -0.4221 -0.8328 3052759 PK04_100113 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F16 compound treatment 1.30325817E8 -2.95E7 -0.77 1.59643911E8 -1.66E7 -0.47 -0.8774 -0.9711 3176780 PK04_100114 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F17 mock treatment 1.38427145E8 -2.14E7 -0.56 1.71036457E8 -5210000.0 -0.15 -0.5004 -0.8632 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F18 mock treatment 1.47229691E8 -1.26E7 -0.33 1.72529648E8 -3720000.0 -0.1 -0.3077 -0.8878 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F19 compound treatment 1.52822105E8 -7030000.0 -0.18 1.73142066E8 -3110000.0 -0.09 -0.192 -0.9423 3176625 PK04_100115 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F20 compound treatment 1.61946933E8 2100000.0 0.05 1.78241517E8 1990000.0 0.06 0.0785 0.9999 3052750 PK04_100116 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F21 compound treatment 1.4513003E8 -1.47E7 -0.39 1.68419548E8 -7830000.0 -0.22 -0.4285 -0.965 3052889 PK04_100117 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F22 compound treatment 1.42148052E8 -1.77E7 -0.46 1.67702394E8 -8550000.0 -0.24 -0.498 -0.9535 3052696 PK04_100118 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F23 compound treatment 1.67204947E8 7350000.0 0.19 1.8349753E8 7250000.0 0.2 0.2806 0.9996 3176674 PK04_100119 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 F24 compound treatment 1.94358225E8 3.45E7 0.9 2.04390039E8 2.81E7 0.79 1.1995 0.9979 3176436 PK04_100120 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G01 compound treatment 1.92878535E8 3.3E7 0.86 2.11656887E8 3.54E7 1.0 1.3169 0.9974 3052845 PK04_100121 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G02 compound treatment 1.87547204E8 2.77E7 0.73 2.00659211E8 2.44E7 0.69 0.9991 0.9997 3052835 PK04_100122 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G03 mock treatment 1.82088374E8 2.22E7 0.58 1.93257904E8 1.7E7 0.48 0.7506 0.9953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G04 mock treatment 1.7447125E8 1.46E7 0.38 1.92374419E8 1.61E7 0.45 0.592 0.9964 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G05 compound treatment 1.69287121E8 9440000.0 0.25 1.87259263E8 1.1E7 0.31 0.3941 0.9936 3176502 PK04_100123 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCN(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G06 compound treatment 1.67900729E8 8050000.0 0.21 1.81466702E8 5220000.0 0.15 0.253 0.9845 3176265 PK04_100124 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G07 compound treatment 1.63005274E8 3150000.0 0.08 1.77448327E8 1200000.0 0.03 0.0823 0.9223 3052742 PK04_100125 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G08 compound treatment 1.62043959E8 2190000.0 0.06 1.87008917E8 1.08E7 0.3 0.255 0.8263 3052639 PK04_100126 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G09 compound treatment 1.65413962E8 5560000.0 0.15 1.81447542E8 5200000.0 0.15 0.2066 1.0 3176200 PK04_100127 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G10 compound treatment 1.53241684E8 -6610000.0 -0.17 1.79084462E8 2840000.0 0.08 -0.0658 -0.3454 3052650 PK04_100128 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G11 compound treatment 1.56000971E8 -3850000.0 -0.1 1.77795103E8 1550000.0 0.04 -0.0404 -0.3683 3176683 PK04_100129 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G12 compound treatment 1.41424247E8 -1.84E7 -0.48 1.68521667E8 -7730000.0 -0.22 -0.495 -0.9354 3176631 PK04_100130 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G13 compound treatment 1.54374854E8 -5480000.0 -0.14 1.81015086E8 4770000.0 0.13 -0.0064 -0.0324 3176045 PK04_100131 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G14 compound treatment 1.5528818E8 -4560000.0 -0.12 1.75552748E8 -696000.0 -0.02 -0.0983 -0.8123 3176196 PK04_100132 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G15 compound treatment 1.2576359E8 -3.41E7 -0.89 1.41953753E8 -3.43E7 -0.97 -1.3143 -0.9992 3176446 PK04_100133 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G16 compound treatment 1.45034251E8 -1.48E7 -0.39 1.73996363E8 -2250000.0 -0.06 -0.3191 -0.812 3052834 PK04_100134 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G17 compound treatment 1.5327568E8 -6570000.0 -0.17 1.80903088E8 4650000.0 0.13 -0.0289 -0.1338 3052640 PK04_100135 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G18 compound treatment 1.52340284E8 -7510000.0 -0.2 1.77357029E8 1110000.0 0.03 -0.1169 -0.5874 3176727 PK04_100136 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G19 mock treatment 1.57467477E8 -2380000.0 -0.06 1.74051232E8 -2200000.0 -0.06 -0.0879 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G20 mock treatment 1.62916481E8 3070000.0 0.08 1.77585761E8 1340000.0 0.04 0.0834 0.9406 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G21 compound treatment 1.63179301E8 3330000.0 0.09 1.76733037E8 485000.0 0.01 0.0713 0.8081 3176272 PK04_100137 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G22 compound treatment 1.73087887E8 1.32E7 0.35 1.85184076E8 8940000.0 0.25 0.4231 0.9877 3176261 PK04_100138 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G23 compound treatment 1.63851539E8 4000000.0 0.1 1.87034441E8 1.08E7 0.3 0.289 0.8989 3176513 PK04_100139 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 G24 compound treatment 1.93120142E8 3.33E7 0.87 1.93188289E8 1.69E7 0.48 0.9534 0.9599 3052924 PK04_100140 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H01 compound treatment 1.98793191E8 3.89E7 1.02 2.10624079E8 3.44E7 0.97 1.4058 0.9997 3176557 PK04_100141 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H02 compound treatment 1.7279419E8 1.29E7 0.34 1.85213629E8 8970000.0 0.25 0.4182 0.9896 3052875 PK04_100142 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H03 mock treatment 1.7879932E8 1.89E7 0.5 1.94413151E8 1.82E7 0.51 0.7127 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H04 mock treatment 1.73520516E8 1.37E7 0.36 1.82379271E8 6130000.0 0.17 0.3752 0.9442 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H05 compound treatment 1.3514709E8 -2.47E7 -0.65 1.4705458E8 -2.92E7 -0.82 -1.039 -0.9929 3052652 PK04_100143 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H06 compound treatment 1.69840743E8 9990000.0 0.26 1.84543542E8 8300000.0 0.23 0.3502 0.9984 3052786 PK04_100144 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H07 compound treatment 1.338633E8 -2.6E7 -0.68 1.54290366E8 -2.2E7 -0.62 -0.9186 -0.9989 3176328 PK04_100145 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H08 compound treatment 1.59483625E8 -367000.0 -0.01 1.80965316E8 4720000.0 0.13 0.0872 0.6543 3176321 PK04_100146 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H09 compound treatment 1.57890278E8 -1960000.0 -0.05 1.74497432E8 -1750000.0 -0.05 -0.0712 -0.9998 3176735 PK04_100147 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H10 compound treatment 1.5991768E8 67100.0 0.0 1.80906192E8 4660000.0 0.13 0.0941 0.7165 3175969 PK04_100148 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H11 compound treatment 1.49939589E8 -9910000.0 -0.26 1.74024711E8 -2220000.0 -0.06 -0.2278 -0.8534 3176193 PK04_100149 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H12 compound treatment 1.44774588E8 -1.51E7 -0.39 1.71359015E8 -4890000.0 -0.14 -0.3765 -0.9007 3176050 PK04_100150 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H13 compound treatment 1.46537588E8 -1.33E7 -0.35 1.61999923E8 -1.42E7 -0.4 -0.5303 -0.9975 3176569 PK04_100151 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H14 compound treatment 1.31928785E8 -2.79E7 -0.73 1.53683118E8 -2.26E7 -0.64 -0.9665 -0.9976 3052874 PK04_100152 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H15 compound treatment 1.53508924E8 -6340000.0 -0.17 1.74824968E8 -1420000.0 -0.04 -0.1457 -0.8534 3052832 PK04_100153 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H16 compound treatment 1.38214585E8 -2.16E7 -0.57 1.52659479E8 -2.36E7 -0.66 -0.8705 -0.9968 3176267 PK04_100154 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H17 compound treatment 1.2983848E8 -3.0E7 -0.79 1.48971456E8 -2.73E7 -0.77 -1.0991 -0.9999 3176378 PK04_100155 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H18 compound treatment 1.55430874E8 -4420000.0 -0.12 1.72279804E8 -3970000.0 -0.11 -0.1609 -0.9999 3176322 PK04_100156 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H19 mock treatment 1.55981263E8 -3870000.0 -0.1 1.77721419E8 1470000.0 0.04 -0.0423 -0.3861 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H20 mock treatment 1.48271007E8 -1.16E7 -0.3 1.71682325E8 -4570000.0 -0.13 -0.3053 -0.9272 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H21 compound treatment 1.5359397E8 -6260000.0 -0.16 1.78989486E8 2740000.0 0.08 -0.0612 -0.3379 3052801 PK04_100157 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H22 compound treatment 1.68916167E8 9070000.0 0.24 1.82985162E8 6740000.0 0.19 0.302 0.9939 3176726 PK04_100158 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H23 compound treatment 1.79918576E8 2.01E7 0.53 1.93932839E8 1.77E7 0.5 0.7238 0.9997 3176558 PK04_100159 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 H24 compound treatment 1.90456979E8 3.06E7 0.8 1.99582128E8 2.33E7 0.66 1.0315 0.9952 3052704 PK04_100160 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I01 compound treatment 1.99839557E8 4.0E7 1.05 2.10166897E8 3.39E7 0.96 1.4161 0.999 3052648 PK04_100161 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I02 compound treatment 1.84672157E8 2.48E7 0.65 2.03684935E8 2.74E7 0.77 1.0062 0.9963 3176506 PK04_100162 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I03 compound treatment 1.73395179E8 1.35E7 0.35 1.89840613E8 1.36E7 0.38 0.5216 0.9993 3176274 PK04_100163 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I04 compound treatment 1.70819079E8 1.1E7 0.29 1.93109585E8 1.69E7 0.48 0.539 0.9709 3176679 PK04_100164 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I05 mock treatment 1.68518895E8 8670000.0 0.23 1.88745644E8 1.25E7 0.35 0.4095 0.9774 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I06 mock treatment 1.65848789E8 6000000.0 0.16 1.77622992E8 1370000.0 0.04 0.1384 0.8559 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I07 compound treatment 1.66661203E8 6810000.0 0.18 1.86012562E8 9760000.0 0.28 0.3206 0.9779 3052930 PK04_100165 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I08 compound treatment 1.63629399E8 3780000.0 0.1 1.83206084E8 6960000.0 0.2 0.2086 0.9498 3176444 PK04_100166 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I09 compound treatment 1.64999583E8 5150000.0 0.13 1.7508579E8 -1160000.0 -0.03 0.0721 0.5201 3052697 PK04_100167 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I10 compound treatment 1.57178409E8 -2670000.0 -0.07 1.79232997E8 2980000.0 0.08 0.01 0.0915 3176731 PK04_100168 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I11 compound treatment 1.53048111E8 -6800000.0 -0.18 1.77085108E8 837000.0 0.02 -0.1092 -0.6082 3052535 PK04_100169 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I12 compound treatment 1.50856563E8 -8990000.0 -0.24 1.74916848E8 -1330000.0 -0.04 -0.193 -0.8096 3176198 PK04_100170 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I13 compound treatment 1.38644669E8 -2.12E7 -0.56 1.65727063E8 -1.05E7 -0.3 -0.6022 -0.9569 3176119 PK04_100171 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I14 compound treatment 1.53632442E8 -6220000.0 -0.16 1.82266594E8 6020000.0 0.17 0.0048 0.0205 3176442 PK04_100172 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I15 compound treatment 1.47291086E8 -1.26E7 -0.33 1.70471726E8 -5780000.0 -0.16 -0.3476 -0.9474 3176566 PK04_100173 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I16 compound treatment 1.55923565E8 -3930000.0 -0.1 1.81177899E8 4930000.0 0.14 0.0255 0.1478 3052844 PK04_100174 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I17 compound treatment 1.49263022E8 -1.06E7 -0.28 1.69702576E8 -6550000.0 -0.18 -0.3264 -0.9804 3176781 PK04_100175 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I18 compound treatment 1.51699076E8 -8150000.0 -0.21 1.73807773E8 -2440000.0 -0.07 -0.1995 -0.8899 3052891 PK04_100176 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I19 compound treatment 1.54561767E8 -5290000.0 -0.14 1.72002572E8 -4250000.0 -0.12 -0.1825 -0.9974 3052840 PK04_100177 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I20 compound treatment 1.61623006E8 1770000.0 0.05 1.78945527E8 2700000.0 0.08 0.0866 0.972 3174821 PK04_100178 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I21 mock treatment 1.67820511E8 7970000.0 0.21 1.7967683E8 3430000.0 0.1 0.2158 0.9388 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I22 mock treatment 1.57034976E8 -2820000.0 -0.07 1.80117058E8 3870000.0 0.11 0.025 0.1898 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I23 compound treatment 1.82734903E8 2.29E7 0.6 1.8346423E8 7220000.0 0.2 0.5674 0.8969 3176670 PK04_100179 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 I24 compound treatment 2.01836422E8 4.2E7 1.1 2.13540864E8 3.73E7 1.05 1.5203 0.9997 3176728 PK04_100180 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J01 compound treatment 1.97803479E8 3.8E7 0.99 2.11743324E8 3.55E7 1.0 1.4098 1.0 3176783 PK04_100181 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J02 compound treatment 1.78805246E8 1.9E7 0.5 1.9936901E8 2.31E7 0.65 0.8116 0.991 3176448 PK04_100182 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J03 compound treatment 1.66959327E8 7110000.0 0.19 1.77680195E8 1430000.0 0.04 0.1601 0.8409 3176047 PK04_100183 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J04 compound treatment 1.63729465E8 3880000.0 0.1 1.76992343E8 744000.0 0.02 0.0866 0.8355 3176269 PK04_100184 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J05 mock treatment 1.62370778E8 2520000.0 0.07 1.73908185E8 -2340000.0 -0.07 0.0 2.0E-4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J06 mock treatment 1.62883342E8 3030000.0 0.08 1.73719238E8 -2530000.0 -0.07 0.0057 0.0538 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J07 compound treatment 1.61031847E8 1180000.0 0.03 1.69578263E8 -6670000.0 -0.19 -0.111 -0.583 3176635 PK04_100185 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J08 compound treatment 1.65816465E8 5970000.0 0.16 1.7120647E8 -5040000.0 -0.14 0.01 0.0472 3176114 PK04_100186 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J09 compound treatment 1.70146209E8 1.03E7 0.27 1.86947886E8 1.07E7 0.3 0.4038 0.9984 3175966 PK04_100187 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J10 compound treatment 1.55052888E8 -4800000.0 -0.13 1.70877117E8 -5370000.0 -0.15 -0.1958 -0.9957 3052757 PK04_100188 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J11 compound treatment 1.59329724E8 -521000.0 -0.01 1.74753349E8 -1500000.0 -0.04 -0.0394 -0.8905 3174819 PK04_100189 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J12 compound treatment 1.53322706E8 -6530000.0 -0.17 1.74296956E8 -1950000.0 -0.05 -0.1597 -0.8897 3176738 PK04_100190 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J13 compound treatment 1.46168953E8 -1.37E7 -0.36 1.74057889E8 -2190000.0 -0.06 -0.2969 -0.8169 3176380 PK04_100191 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J14 compound treatment 1.55774025E8 -4080000.0 -0.11 1.77473667E8 1230000.0 0.03 -0.051 -0.4551 3176199 PK04_100192 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J15 compound treatment 1.53298761E8 -6550000.0 -0.17 1.6784701E8 -8400000.0 -0.24 -0.2887 -0.9875 3176623 PK04_100193 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J16 compound treatment 1.43947907E8 -1.59E7 -0.42 1.63793707E8 -1.25E7 -0.35 -0.5425 -0.9964 3176632 PK04_100194 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J17 compound treatment 1.5539447E8 -4460000.0 -0.12 1.70541756E8 -5710000.0 -0.16 -0.1962 -0.9876 3052795 PK04_100195 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J18 compound treatment 1.56415447E8 -3440000.0 -0.09 1.70873144E8 -5380000.0 -0.15 -0.1707 -0.969 3052636 PK04_100196 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J19 compound treatment 1.39188237E8 -2.07E7 -0.54 1.5590199E8 -2.03E7 -0.57 -0.7879 -0.9996 3052591 PK04_100197 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J20 compound treatment 1.62135117E8 2280000.0 0.06 1.79916616E8 3670000.0 0.1 0.1154 0.9662 3176629 PK04_100198 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J21 mock treatment 1.6638442E8 6530000.0 0.17 1.75478745E8 -770000.0 -0.02 0.1056 0.6125 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J22 mock treatment 1.66980228E8 7130000.0 0.19 1.84668684E8 8420000.0 0.24 0.2998 0.9929 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J23 compound treatment 1.82862059E8 2.3E7 0.6 1.96052474E8 1.98E7 0.56 0.8206 0.9993 3176776 PK04_100199 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 J24 compound treatment 1.94808853E8 3.5E7 0.92 2.02077519E8 2.58E7 0.73 1.1618 0.9936 3052544 PK04_100200 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K01 compound treatment 1.97580263E8 3.77E7 0.99 2.13542908E8 3.73E7 1.05 1.4415 0.9995 3176739 PK04_100201 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K02 compound treatment 1.78005894E8 1.82E7 0.48 1.99620319E8 2.34E7 0.66 0.8018 0.9872 3176042 PK04_100202 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K03 compound treatment 1.64486319E8 4640000.0 0.12 1.82696274E8 6450000.0 0.18 0.2143 0.9807 3052528 PK04_100203 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K04 compound treatment 1.73290575E8 1.34E7 0.35 1.92844818E8 1.66E7 0.47 0.5795 0.9902 3176564 PK04_100204 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K05 compound treatment 1.5647594E8 -3370000.0 -0.09 1.64738895E8 -1.15E7 -0.32 -0.2918 -0.8681 3176329 PK04_100205 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K06 compound treatment 1.59199889E8 -651000.0 -0.02 1.75280427E8 -968000.0 -0.03 -0.0313 -0.9743 3052588 PK04_100206 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K07 mock treatment 1.61733128E8 1880000.0 0.05 1.59967933E8 -1.63E7 -0.46 -0.2896 -0.6275 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K08 mock treatment 1.63515197E8 3660000.0 0.1 1.76417914E8 170000.0 0.0 0.0712 0.7414 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K09 compound treatment 1.36704452E8 -2.31E7 -0.61 1.56421412E8 -1.98E7 -0.56 -0.8235 -0.9992 3176733 PK04_100207 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K10 compound treatment 1.57766929E8 -2080000.0 -0.05 1.68800283E8 -7450000.0 -0.21 -0.187 -0.8622 3052589 PK04_100208 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K11 compound treatment 1.63190072E8 3340000.0 0.09 1.80709635E8 4460000.0 0.13 0.1507 0.9842 3052651 PK04_100209 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K12 compound treatment 1.49632094E8 -1.02E7 -0.27 1.70597351E8 -5650000.0 -0.16 -0.3017 -0.9693 3176507 PK04_100210 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K13 compound treatment 1.50818002E8 -9030000.0 -0.24 1.70142139E8 -6110000.0 -0.17 -0.2889 -0.9878 3052706 PK04_100211 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K14 compound treatment 1.54349162E8 -5500000.0 -0.14 1.70172303E8 -6080000.0 -0.17 -0.2229 -0.9963 3175959 PK04_100212 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K15 mock treatment 1.50860252E8 -8990000.0 -0.24 1.68395942E8 -7850000.0 -0.22 -0.3229 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K16 mock treatment 1.54854537E8 -5000000.0 -0.13 1.74778714E8 -1470000.0 -0.04 -0.1218 -0.8876 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K17 compound treatment 1.59744794E8 -106000.0 0.0 1.75304611E8 -944000.0 -0.03 -0.0208 -0.7765 3174817 PK04_100213 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K18 compound treatment 1.58174582E8 -1680000.0 -0.04 1.63371251E8 -1.29E7 -0.36 -0.2876 -0.7869 3176725 PK04_100214 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K19 compound treatment 1.53611666E8 -6240000.0 -0.16 1.69959083E8 -6290000.0 -0.18 -0.2408 -0.9992 3052537 PK04_100215 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K20 compound treatment 1.61654061E8 1800000.0 0.05 1.82292322E8 6040000.0 0.17 0.1538 0.8703 3052596 PK04_100216 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K21 compound treatment 1.64094983E8 4240000.0 0.11 1.79178228E8 2930000.0 0.08 0.1369 0.9893 3176049 PK04_100217 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K22 compound treatment 1.65712382E8 5860000.0 0.15 1.77817748E8 1570000.0 0.04 0.1398 0.8753 3052637 PK04_100218 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K23 mock treatment 1.69485598E8 9630000.0 0.25 1.8448042E8 8230000.0 0.23 0.3424 0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 K24 mock treatment 2.03637349E8 4.38E7 1.15 2.06339113E8 3.01E7 0.85 1.4101 0.989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L01 compound treatment 2.02379535E8 4.25E7 1.11 2.11925022E8 3.57E7 1.01 1.4981 0.9987 3052595 PK04_100219 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L02 compound treatment 1.66939512E8 7090000.0 0.19 1.799176E8 3670000.0 0.1 0.2043 0.9619 3176046 PK04_100220 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L03 compound treatment 1.77096777E8 1.72E7 0.45 1.94316615E8 1.81E7 0.51 0.6793 0.9982 3052585 PK04_100221 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L04 compound treatment 1.5159112E8 -8260000.0 -0.22 1.69819644E8 -6430000.0 -0.18 -0.281 -0.9961 3176734 PK04_100222 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L05 compound treatment 1.69603493E8 9750000.0 0.26 1.86417789E8 1.02E7 0.29 0.3832 0.9983 3176688 PK04_100223 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L06 compound treatment 1.65255336E8 5400000.0 0.14 1.77540054E8 1290000.0 0.04 0.1258 0.861 3176372 PK04_100224 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L07 mock treatment 1.6421861E8 4370000.0 0.11 1.80815856E8 4570000.0 0.13 0.1719 0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L08 mock treatment 1.64680666E8 4830000.0 0.13 1.73745627E8 -2500000.0 -0.07 0.0395 0.2731 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L09 compound treatment 1.64239788E8 4390000.0 0.11 1.77347082E8 1100000.0 0.03 0.1031 0.8667 3176559 PK04_100225 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L10 compound treatment 1.62091329E8 2240000.0 0.06 1.76136856E8 -112000.0 0.0 0.0393 0.6683 3052527 PK04_100226 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L11 compound treatment 1.56587409E8 -3260000.0 -0.09 1.66861335E8 -9390000.0 -0.26 -0.2475 -0.8902 3176432 PK04_100227 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L12 compound treatment 1.39153201E8 -2.07E7 -0.54 1.57987388E8 -1.83E7 -0.51 -0.747 -0.9997 3176326 PK04_100228 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L13 compound treatment 1.49547156E8 -1.03E7 -0.27 1.64688228E8 -1.16E7 -0.33 -0.4211 -0.9956 3176737 PK04_100229 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L14 compound treatment 1.61884927E8 2030000.0 0.05 1.78939411E8 2690000.0 0.08 0.0913 0.985 3175964 PK04_100230 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L15 mock treatment 1.54366658E8 -5480000.0 -0.14 1.63697529E8 -1.26E7 -0.35 -0.3516 -0.9211 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L16 mock treatment 1.52589404E8 -7260000.0 -0.19 1.64424736E8 -1.18E7 -0.33 -0.37 -0.9646 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L17 compound treatment 1.61516176E8 1670000.0 0.04 1.69084398E8 -7160000.0 -0.2 -0.1119 -0.5419 3176787 PK04_100231 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L18 compound treatment 1.58420433E8 -1430000.0 -0.04 1.69120498E8 -7130000.0 -0.2 -0.1685 -0.8247 3175960 PK04_100232 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L19 compound treatment 1.52663971E8 -7190000.0 -0.19 1.69498145E8 -6750000.0 -0.19 -0.2675 -1.0 3176273 PK04_100233 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L20 compound treatment 1.68384674E8 8530000.0 0.22 1.80214555E8 3970000.0 0.11 0.237 0.9488 3052882 PK04_100234 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L21 compound treatment 1.61370405E8 1520000.0 0.04 1.65968547E8 -1.03E7 -0.29 -0.1767 -0.6043 3176053 PK04_100235 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L22 compound treatment 1.59705346E8 -145000.0 0.0 1.68397255E8 -7850000.0 -0.22 -0.1591 -0.7192 3052696 PK04_100236 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L23 mock treatment 1.7477638E8 1.49E7 0.39 1.87020339E8 1.08E7 0.3 0.4909 0.9922 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 L24 mock treatment 2.0442245E8 4.46E7 1.17 2.05508186E8 2.93E7 0.82 1.4081 0.9856 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M01 compound treatment 2.09218017E8 4.94E7 1.29 2.23508567E8 4.73E7 1.33 1.8555 0.9999 3176052 PK04_100237 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M02 compound treatment 1.69410377E8 9560000.0 0.25 1.89057938E8 1.28E7 0.36 0.4322 0.984 3176323 PK04_100238 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M03 compound treatment 1.72597448E8 1.27E7 0.33 1.84953764E8 8710000.0 0.25 0.4094 0.9886 3176206 PK04_100239 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M04 compound treatment 1.64998185E8 5150000.0 0.13 1.6945286E8 -6800000.0 -0.19 -0.0401 -0.1714 3052883 PK04_100240 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M05 compound treatment 1.61407114E8 1560000.0 0.04 1.85038375E8 8790000.0 0.25 0.204 0.8125 3052744 PK04_100241 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M06 compound treatment 1.61842144E8 1990000.0 0.05 1.62510497E8 -1.37E7 -0.39 -0.2369 -0.6064 3176505 PK04_100242 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M07 compound treatment 1.65062658E8 5210000.0 0.14 1.63732033E8 -1.25E7 -0.35 -0.1529 -0.4044 3176434 PK04_100243 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M08 compound treatment 1.72339788E8 1.25E7 0.33 1.84608648E8 8360000.0 0.24 0.3978 0.9871 3176729 PK04_100244 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M09 mock treatment 1.68325736E8 8480000.0 0.22 1.75879354E8 -369000.0 -0.01 0.1495 0.6732 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M10 mock treatment 1.6393912E8 4090000.0 0.11 1.63576576E8 -1.27E7 -0.36 -0.1768 -0.4743 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M11 compound treatment 1.08193989E8 -5.17E7 -1.35 1.24653017E8 -5.16E7 -1.45 -1.9843 -0.9993 3052590 PK04_100245 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M12 compound treatment 1.61170458E8 1320000.0 0.03 1.73930072E8 -2320000.0 -0.07 -0.0218 -0.2945 3176565 PK04_100246 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M13 mock treatment 1.53554776E8 -6300000.0 -0.16 1.68476009E8 -7770000.0 -0.22 -0.2714 -0.9902 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M14 mock treatment 1.49110647E8 -1.07E7 -0.28 1.66248856E8 -1.0E7 -0.28 -0.3981 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M15 compound treatment 1.54805146E8 -5050000.0 -0.13 1.53201407E8 -2.3E7 -0.65 -0.5526 -0.8338 3176508 PK04_100247 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M16 compound treatment 1.5999778E8 147000.0 0.0 1.48285714E8 -2.8E7 -0.79 -0.5545 -0.7036 3052587 PK04_100248 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M17 compound treatment 1.53263746E8 -6590000.0 -0.17 1.62829737E8 -1.34E7 -0.38 -0.3893 -0.9367 3052643 PK04_100249 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M18 compound treatment 1.6153805E8 1690000.0 0.04 1.60794335E8 -1.55E7 -0.44 -0.2767 -0.6321 3176777 PK04_100250 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M19 compound treatment 1.61973886E8 2120000.0 0.06 1.61468901E8 -1.48E7 -0.42 -0.2552 -0.6074 3052583 PK04_100251 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M20 compound treatment 1.57446377E8 -2400000.0 -0.06 1.6358424E8 -1.27E7 -0.36 -0.2969 -0.8192 3052586 PK04_100252 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M21 compound treatment 1.78323239E8 1.85E7 0.48 1.85334624E8 9090000.0 0.26 0.523 0.9558 3052593 PK04_100253 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M22 compound treatment 1.77330775E8 1.75E7 0.46 1.7616643E8 -82000.0 0.0 0.3219 0.7035 3176374 PK04_100254 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M23 compound treatment 1.74266795E8 1.44E7 0.38 1.83656473E8 7410000.0 0.21 0.4145 0.961 3052699 PK04_100255 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 M24 compound treatment 2.11503701E8 5.17E7 1.35 2.04072833E8 2.78E7 0.78 1.5105 0.9664 3176628 PK04_100256 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N01 compound treatment 2.03126416E8 4.33E7 1.13 2.13318424E8 3.71E7 1.04 1.5397 0.9992 3052530 PK04_100257 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N02 compound treatment 1.80395546E8 2.05E7 0.54 1.979913E8 2.17E7 0.61 0.8135 0.9979 3176510 PK04_100258 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N03 compound treatment 1.68368501E8 8520000.0 0.22 1.83673249E8 7420000.0 0.21 0.3056 0.9995 3052646 PK04_100259 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N04 compound treatment 1.68039698E8 8190000.0 0.21 1.78746821E8 2500000.0 0.07 0.2014 0.8924 3176040 PK04_100260 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N05 compound treatment 1.58652765E8 -1200000.0 -0.03 1.75420481E8 -828000.0 -0.02 -0.0387 -0.9894 3052838 PK04_100261 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N06 compound treatment 1.6748725E8 7640000.0 0.2 1.68526314E8 -7720000.0 -0.22 -0.0125 -0.0424 3176263 PK04_100262 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N07 compound treatment 1.63029516E8 3180000.0 0.08 1.70055116E8 -6190000.0 -0.17 -0.0646 -0.3339 3176511 PK04_100263 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N08 compound treatment 1.64797941E8 4950000.0 0.13 1.64814308E8 -1.14E7 -0.32 -0.1363 -0.3924 3052644 PK04_100264 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N09 mock treatment 1.65988985E8 6140000.0 0.16 1.60195842E8 -1.61E7 -0.45 -0.2063 -0.4296 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N10 mock treatment 1.59839223E8 -11400.0 0.0 1.70731321E8 -5520000.0 -0.16 -0.1101 -0.7085 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N11 compound treatment 1.68550311E8 8700000.0 0.23 1.72446268E8 -3800000.0 -0.11 0.0853 0.3388 3052880 PK04_100265 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N12 compound treatment 1.53455066E8 -6400000.0 -0.17 1.66180835E8 -1.01E7 -0.28 -0.319 -0.9683 3176732 PK04_100266 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N13 mock treatment 1.58436852E8 -1410000.0 -0.04 1.60578876E8 -1.57E7 -0.44 -0.3384 -0.7637 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N14 mock treatment 1.54647176E8 -5200000.0 -0.14 1.56816037E8 -1.94E7 -0.55 -0.4835 -0.8569 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N15 compound treatment 1.5522431E8 -4630000.0 -0.12 1.66605798E8 -9640000.0 -0.27 -0.2778 -0.9337 3052703 PK04_100267 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N16 compound treatment 1.66569871E8 6720000.0 0.18 1.60111588E8 -1.61E7 -0.45 -0.1972 -0.4044 3176120 PK04_100268 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N17 compound treatment 1.72168195E8 1.23E7 0.32 1.7515505E8 -1090000.0 -0.03 0.2062 0.6366 3052843 PK04_100269 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N18 compound treatment 1.65788066E8 5940000.0 0.16 1.59630446E8 -1.66E7 -0.47 -0.2212 -0.4484 3176116 PK04_100270 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N19 compound treatment 1.61426978E8 1580000.0 0.04 1.59731657E8 -1.65E7 -0.47 -0.2999 -0.6419 3176319 PK04_100271 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N20 compound treatment 1.80843448E8 2.1E7 0.55 1.89588713E8 1.33E7 0.38 0.6544 0.9829 3052797 PK04_100272 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N21 compound treatment 1.70620645E8 1.08E7 0.28 1.68026752E8 -8220000.0 -0.23 0.0355 0.0973 3052581 PK04_100273 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N22 compound treatment 1.79621838E8 1.98E7 0.52 1.72098441E8 -4150000.0 -0.12 0.2833 0.5339 3176118 PK04_100274 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N23 compound treatment 1.9153313E8 3.17E7 0.83 1.84629393E8 8380000.0 0.24 0.7534 0.8737 3176207 PK04_100275 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 N24 compound treatment 2.08939101E8 4.91E7 1.28 1.97843825E8 2.16E7 0.61 1.3389 0.9417 3176266 PK04_100276 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O01 compound treatment 2.1000228E8 5.02E7 1.31 2.17137338E8 4.09E7 1.15 1.7431 0.9979 3176687 PK04_100277 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O02 compound treatment 1.77993931E8 1.81E7 0.47 1.94917233E8 1.87E7 0.53 0.7078 0.9987 3176323 PK04_100278 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O03 compound treatment 1.71927522E8 1.21E7 0.32 1.87505815E8 1.13E7 0.32 0.4479 1.0 3176438 PK04_100279 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O04 compound treatment 1.7969888E8 1.98E7 0.52 1.9090122E8 1.47E7 0.41 0.6594 0.9935 3176117 PK04_100280 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O05 compound treatment 1.80485307E8 2.06E7 0.54 1.73681408E8 -2570000.0 -0.07 0.3308 0.607 3176384 PK04_100281 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O06 compound treatment 1.69201953E8 9350000.0 0.24 1.71994982E8 -4250000.0 -0.12 0.0883 0.3241 3052695 PK04_100282 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O07 compound treatment 1.71336684E8 1.15E7 0.3 1.844374E8 8190000.0 0.23 0.3758 0.9915 3052929 PK04_100283 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O08 compound treatment 1.73970504E8 1.41E7 0.37 1.66414732E8 -9830000.0 -0.28 0.0654 0.1416 3052798 PK04_100284 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O09 compound treatment 1.69712393E8 9860000.0 0.26 1.7159403E8 -4650000.0 -0.13 0.0898 0.3101 3176509 PK04_100285 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O10 compound treatment 1.64069708E8 4220000.0 0.11 1.62076128E8 -1.42E7 -0.4 -0.2043 -0.4931 3176681 PK04_100286 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O11 mock treatment 1.62578436E8 2730000.0 0.07 1.61915707E8 -1.43E7 -0.4 -0.2351 -0.5732 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O12 mock treatment 1.61684421E8 1830000.0 0.05 1.67691467E8 -8560000.0 -0.24 -0.1366 -0.5554 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O13 compound treatment 1.62293603E8 2440000.0 0.06 1.62657977E8 -1.36E7 -0.38 -0.2256 -0.581 3176682 PK04_100287 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O14 compound treatment 1.65665953E8 5820000.0 0.15 1.69036507E8 -7210000.0 -0.2 -0.0361 -0.142 3176320 PK04_100288 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O15 compound treatment 1.62480355E8 2630000.0 0.07 1.66756755E8 -9490000.0 -0.27 -0.1405 -0.5086 3176268 PK04_100289 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O16 compound treatment 1.6867479E8 8820000.0 0.23 1.71143902E8 -5100000.0 -0.14 0.0616 0.2264 3176373 PK04_100290 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O17 compound treatment 1.77312863E8 1.75E7 0.46 1.86303955E8 1.01E7 0.28 0.5236 0.9736 3052700 PK04_100291 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O18 compound treatment 1.69572575E8 9720000.0 0.25 1.74588626E8 -1660000.0 -0.05 0.1469 0.5676 3176275 PK04_100292 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O19 compound treatment 1.64697811E8 4850000.0 0.13 1.61415413E8 -1.48E7 -0.42 -0.2058 -0.4712 3052887 PK04_100293 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O20 compound treatment 1.68972385E8 9120000.0 0.24 1.72573404E8 -3680000.0 -0.1 0.0956 0.3674 3176039 PK04_100294 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O21 compound treatment 1.81820101E8 2.2E7 0.58 1.94990802E8 1.87E7 0.53 0.7801 0.9991 3176637 PK04_100295 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O22 compound treatment 1.91483548E8 3.16E7 0.83 1.83222758E8 6970000.0 0.2 0.7245 0.8513 3176115 PK04_100296 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O23 compound treatment 2.02797502E8 4.29E7 1.12 1.98888508E8 2.26E7 0.64 1.2461 0.964 3052755 PK04_100297 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 O24 compound treatment 2.2318641E8 6.33E7 1.66 2.28518188E8 5.23E7 1.47 2.2139 0.9983 3176443 PK04_100298 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P01 compound treatment 2.03871804E8 4.4E7 1.15 2.10847825E8 3.46E7 0.98 1.5043 0.9965 3052698 PK04_100299 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P02 compound treatment 1.9970369E8 3.99E7 1.04 2.19977301E8 4.37E7 1.23 1.609 0.9966 3176634 PK04_100300 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P03 compound treatment 1.96279402E8 3.64E7 0.95 2.15203508E8 3.9E7 1.1 1.4505 0.9975 3174820 PK04_100301 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P04 compound treatment 1.99072142E8 3.92E7 1.03 2.13983748E8 3.77E7 1.06 1.4779 0.9998 3052597 PK04_100302 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P05 compound treatment 1.67213087E8 7360000.0 0.19 1.92252821E8 1.6E7 0.45 0.4552 0.9281 3176270 PK04_100303 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P06 compound treatment 1.93491908E8 3.36E7 0.88 1.93954373E8 1.77E7 0.5 0.9755 0.9638 3176677 PK04_100304 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P07 compound treatment 1.92829122E8 3.3E7 0.86 2.06011725E8 2.98E7 0.84 1.2035 0.9999 3176122 PK04_100305 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P08 compound treatment 1.86365525E8 2.65E7 0.69 1.90094798E8 1.38E7 0.39 0.7667 0.9629 3052701 PK04_100306 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P09 compound treatment 1.86159546E8 2.63E7 0.69 1.96984066E8 2.07E7 0.58 0.9002 0.9967 3175972 PK04_100307 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P10 compound treatment 1.84224243E8 2.44E7 0.64 1.96700559E8 2.05E7 0.58 0.8587 0.9987 3052830 PK04_100308 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P11 mock treatment 1.89324041E8 2.95E7 0.77 1.79966499E8 3720000.0 0.1 0.6196 0.7958 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P12 mock treatment 1.89278565E8 2.94E7 0.77 1.76981595E8 733000.0 0.02 0.5593 0.7258 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P13 compound treatment 1.9234057E8 3.25E7 0.85 1.97767991E8 2.15E7 0.61 1.0302 0.9863 3052541 PK04_100309 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P14 compound treatment 1.78513544E8 1.87E7 0.49 1.68714189E8 -7530000.0 -0.21 0.1953 0.3667 3052545 PK04_100310 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P15 compound treatment 1.87226736E8 2.74E7 0.72 2.02126114E8 2.59E7 0.73 1.0224 1.0 3176381 PK04_100311 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P16 compound treatment 1.74080602E8 1.42E7 0.37 1.62755467E8 -1.35E7 -0.38 -0.0055 -0.0103 3052789 PK04_100312 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P17 compound treatment 1.86664895E8 2.68E7 0.7 1.88431127E8 1.22E7 0.34 0.7391 0.9459 3052890 PK04_100313 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P18 compound treatment 1.75862415E8 1.6E7 0.42 1.71615994E8 -4630000.0 -0.13 0.2041 0.4648 3176779 PK04_100314 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P19 compound treatment 1.8317317E8 2.33E7 0.61 1.67153582E8 -9090000.0 -0.26 0.2505 0.3783 3052876 PK04_100315 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P20 compound treatment 1.98750646E8 3.89E7 1.02 2.00647984E8 2.44E7 0.69 1.2062 0.9817 3176264 PK04_100316 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P21 compound treatment 1.82290896E8 2.24E7 0.59 1.89362447E8 1.31E7 0.37 0.6767 0.9751 3052692 PK04_100317 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P22 compound treatment 2.01785543E8 4.19E7 1.1 2.03795033E8 2.75E7 0.78 1.3251 0.9856 3176051 PK04_100318 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P23 compound treatment 2.12983797E8 5.31E7 1.39 2.28536426E8 5.23E7 1.47 2.0254 0.9996 3052754 PK04_100319 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2100 P24 compound treatment 2.29881222E8 7.0E7 1.83 2.32680579E8 5.64E7 1.59 2.4208 0.9975 3176127 PK04_100320 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A01 compound treatment 2.45623576E8 7.59E7 1.99 2.16892495E8 6.55E7 1.85 2.7106 0.9993 3189007 PK04_101001 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A02 compound treatment 2.26304423E8 5.66E7 1.48 1.95706255E8 4.43E7 1.25 1.9308 0.9964 3069619 PK04_101002 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A03 compound treatment 2.16013674E8 4.63E7 1.21 1.94332045E8 4.3E7 1.21 1.7129 1.0 3189008 PK04_101003 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A04 compound treatment 2.11873174E8 4.21E7 1.1 1.91354767E8 4.0E7 1.13 1.577 0.9999 3189009 PK04_101004 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A05 compound treatment 2.11301102E8 4.16E7 1.09 1.81936021E8 3.06E7 0.86 1.3787 0.9933 3069620 PK04_101005 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A06 compound treatment 1.93345125E8 2.36E7 0.62 1.79523971E8 2.82E7 0.79 0.9983 0.9923 3189010 PK04_101006 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A07 compound treatment 1.99113775E8 2.94E7 0.77 1.73296344E8 2.19E7 0.62 0.9809 0.9941 3189011 PK04_101007 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A08 compound treatment 2.01876374E8 3.21E7 0.84 1.79694971E8 2.83E7 0.8 1.1596 0.9997 3069621 PK04_101008 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A09 compound treatment 1.98751324E8 2.9E7 0.76 1.74186296E8 2.28E7 0.64 0.992 0.9966 3189120 PK04_101009 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A10 compound treatment 1.9265119E8 2.29E7 0.6 1.63145072E8 1.18E7 0.33 0.659 0.9611 3069622 PK04_101010 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A11 compound treatment 2.0625486E8 3.65E7 0.96 1.77540289E8 2.62E7 0.74 1.1977 0.9918 3189121 PK04_101011 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A12 compound treatment 1.94484571E8 2.47E7 0.65 1.63261575E8 1.19E7 0.34 0.6953 0.9531 3069678 PK04_101012 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A13 mock treatment 2.15904996E8 4.62E7 1.21 1.8586461E8 3.45E7 0.97 1.5422 0.9942 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A14 mock treatment 1.96084584E8 2.63E7 0.69 1.60875919E8 9520000.0 0.27 0.6774 0.9153 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A15 compound treatment 1.95106145E8 2.54E7 0.66 1.64083777E8 1.27E7 0.36 0.7232 0.9582 3189122 PK04_101013 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A16 compound treatment 2.11601991E8 4.19E7 1.1 1.87081047E8 3.57E7 1.01 1.4868 0.9991 3069679 PK04_101014 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A17 compound treatment 1.97161663E8 2.74E7 0.72 1.70841654E8 1.95E7 0.55 0.8959 0.9912 3189123 PK04_101015 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A18 compound treatment 2.1630132E8 4.66E7 1.22 1.90590263E8 3.92E7 1.11 1.6437 0.9988 3189124 PK04_101016 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A19 compound treatment 2.16546485E8 4.68E7 1.23 1.83519225E8 3.22E7 0.91 1.5073 0.989 3069680 PK04_101017 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A20 compound treatment 2.16007983E8 4.63E7 1.21 1.83010815E8 3.17E7 0.89 1.4872 0.9887 3189125 PK04_101018 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A21 compound treatment 2.15406252E8 4.57E7 1.2 1.88996565E8 3.76E7 1.06 1.5954 0.9982 3069681 PK04_101019 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A22 compound treatment 2.23462215E8 5.37E7 1.41 1.95478074E8 4.41E7 1.24 1.8736 0.9981 3189126 PK04_101020 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A23 compound treatment 2.33929684E8 6.42E7 1.68 2.07184076E8 5.58E7 1.57 2.3006 0.9995 3189127 PK04_101021 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 A24 compound treatment 2.32101997E8 6.24E7 1.63 2.25953967E8 7.46E7 2.1 2.6408 0.9922 3069682 PK04_101022 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B01 compound treatment 2.31220663E8 6.15E7 1.61 2.10196865E8 5.88E7 1.66 2.3105 0.9999 3189128 PK04_101023 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B02 compound treatment 1.9018782E8 2.05E7 0.54 1.60559721E8 9200000.0 0.26 0.5619 0.9446 3189129 PK04_101024 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B03 compound treatment 1.91723526E8 2.2E7 0.58 1.64559975E8 1.32E7 0.37 0.6701 0.9777 3069683 PK04_101025 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B04 compound treatment 1.76854035E8 7120000.0 0.19 1.43010959E8 -8350000.0 -0.24 -0.0346 -0.1152 3189130 PK04_101026 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B05 compound treatment 1.93212187E8 2.35E7 0.61 1.61841481E8 1.05E7 0.3 0.6435 0.9437 3069684 PK04_101027 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B06 compound treatment 1.72366232E8 2630000.0 0.07 1.28775931E8 -2.26E7 -0.64 -0.4013 -0.6269 3189131 PK04_101028 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5c(Cl)cccc5CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B07 compound treatment 1.74748143E8 5010000.0 0.13 1.58959098E8 7600000.0 0.21 0.2442 0.9723 3189132 PK04_101029 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B08 compound treatment 1.68323301E8 -1410000.0 -0.04 1.40146782E8 -1.12E7 -0.32 -0.2495 -0.7845 3069685 PK04_101030 OCc1cccc(Cl)c1N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B09 compound treatment 1.8495941E8 1.52E7 0.4 1.56513535E8 5160000.0 0.15 0.3845 0.9065 3189133 PK04_101031 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B10 compound treatment 1.51311654E8 -1.84E7 -0.48 1.30559461E8 -2.08E7 -0.59 -0.7555 -0.9953 3189129 PK04_101032 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B11 compound treatment 1.72834464E8 3100000.0 0.08 1.45423295E8 -5930000.0 -0.17 -0.0609 -0.3276 3189134 PK04_101033 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B12 compound treatment 1.67507225E8 -2230000.0 -0.06 1.38817108E8 -1.25E7 -0.35 -0.2911 -0.8128 3069686 PK04_101034 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B13 mock treatment 1.75697938E8 5960000.0 0.16 1.43073276E8 -8280000.0 -0.23 -0.0547 -0.1949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B14 mock treatment 1.75876072E8 6140000.0 0.16 1.39334956E8 -1.2E7 -0.34 -0.1259 -0.3358 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B15 compound treatment 1.75051153E8 5320000.0 0.14 1.51302299E8 -55100.0 0.0 0.0973 0.6992 3189135 PK04_101035 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B16 compound treatment 1.63535801E8 -6200000.0 -0.16 1.30059933E8 -2.13E7 -0.6 -0.5391 -0.8672 3069686 PK04_101036 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B17 compound treatment 1.78443788E8 8710000.0 0.23 1.46308703E8 -5050000.0 -0.14 0.0606 0.2254 3189136 PK04_101037 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B18 compound treatment 1.86071356E8 1.63E7 0.43 1.48241527E8 -3120000.0 -0.09 0.2403 0.5504 3069687 PK04_101038 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5ccc(CCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B19 compound treatment 1.91940798E8 2.22E7 0.58 1.55518324E8 4160000.0 0.12 0.4939 0.833 3189137 PK04_101039 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B20 compound treatment 2.00197878E8 3.05E7 0.8 1.80466096E8 2.91E7 0.82 1.1439 0.9999 3069688 PK04_101040 OCCc1ccc(cc1)N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B21 compound treatment 1.97431514E8 2.77E7 0.72 1.69114509E8 1.78E7 0.5 0.8665 0.9836 3189138 PK04_101041 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B22 compound treatment 1.95671471E8 2.59E7 0.68 1.67146974E8 1.58E7 0.44 0.7947 0.979 3189139 PK04_101042 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B23 compound treatment 2.09244488E8 3.95E7 1.03 1.86802389E8 3.54E7 1.0 1.4376 0.9998 3069689 PK04_101043 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 B24 compound treatment 2.3499523E8 6.53E7 1.71 2.10381976E8 5.9E7 1.66 2.3841 0.9999 3189140 PK04_101044 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C01 compound treatment 2.2444833E8 5.47E7 1.43 1.89624938E8 3.83E7 1.08 1.7753 0.9902 3189247 PK04_101045 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C02 compound treatment 1.95036003E8 2.53E7 0.66 1.57331616E8 5970000.0 0.17 0.5873 0.8595 3069724 PK04_101046 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C03 compound treatment 1.85971069E8 1.62E7 0.42 1.55415621E8 4060000.0 0.11 0.3814 0.8666 3189248 PK04_101047 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C04 compound treatment 1.78569878E8 8830000.0 0.23 1.55730616E8 4370000.0 0.12 0.2507 0.9566 3189249 PK04_101048 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C05 compound treatment 1.71218518E8 1480000.0 0.04 1.49843294E8 -1510000.0 -0.04 -0.0027 -0.0473 3069725 PK04_101049 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C06 compound treatment 1.78222955E8 8490000.0 0.22 1.42371378E8 -8990000.0 -0.25 -0.022 -0.0652 3189250 PK04_101050 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C07 compound treatment 1.74037556E8 4300000.0 0.11 1.53596382E8 2240000.0 0.06 0.1242 0.9625 3069726 PK04_101051 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C08 compound treatment 1.65365798E8 -4370000.0 -0.11 1.45674678E8 -5680000.0 -0.16 -0.1941 -0.9864 3189251 PK04_101052 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C09 compound treatment 1.82327746E8 1.26E7 0.33 1.6176943E8 1.04E7 0.29 0.4405 0.9983 3189252 PK04_101053 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C10 compound treatment 1.61310801E8 -8430000.0 -0.22 1.37498535E8 -1.39E7 -0.39 -0.4321 -0.9634 3069727 PK04_101054 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C11 mock treatment 1.76619887E8 6880000.0 0.18 1.53370762E8 2010000.0 0.06 0.1675 0.8868 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C12 mock treatment 1.65269379E8 -4470000.0 -0.12 1.4156226E8 -9800000.0 -0.28 -0.2779 -0.9269 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C13 compound treatment 1.81203382E8 1.15E7 0.3 1.51266346E8 -91100.0 0.0 0.2104 0.701 3189253 PK04_101055 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C14 compound treatment 1.62620887E8 -7120000.0 -0.19 1.35344665E8 -1.6E7 -0.45 -0.4508 -0.9234 3069728 PK04_101056 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C15 mock treatment 1.70209147E8 473000.0 0.01 1.40028267E8 -1.13E7 -0.32 -0.217 -0.6792 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C16 mock treatment 1.64052326E8 -5680000.0 -0.15 1.40085271E8 -1.13E7 -0.32 -0.3298 -0.9403 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C17 compound treatment 1.85559753E8 1.58E7 0.41 1.62019889E8 1.07E7 0.3 0.5054 0.9876 3189254 PK04_101057 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C18 compound treatment 1.72922271E8 3190000.0 0.08 1.44505089E8 -6850000.0 -0.19 -0.0776 -0.3688 3189255 PK04_101058 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C19 compound treatment 1.82382713E8 1.26E7 0.33 1.46623559E8 -4730000.0 -0.13 0.1398 0.3916 3069729 PK04_101059 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C20 compound treatment 1.7737255E8 7640000.0 0.2 1.53288109E8 1930000.0 0.05 0.1798 0.868 3189256 PK04_101060 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C21 compound treatment 1.84101887E8 1.44E7 0.38 1.59609356E8 8250000.0 0.23 0.4303 0.9733 3189257 PK04_101061 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C22 compound treatment 1.82717259E8 1.3E7 0.34 1.62402096E8 1.1E7 0.31 0.4604 0.999 3069730 PK04_101062 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C23 compound treatment 1.88562918E8 1.88E7 0.49 1.72773159E8 2.14E7 0.6 0.7752 0.9949 3189258 PK04_101063 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 C24 compound treatment 2.04166864E8 3.44E7 0.9 1.93991826E8 4.26E7 1.2 1.4869 0.99 3069731 PK04_101064 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D01 compound treatment 2.12666667E8 4.29E7 1.12 1.88200994E8 3.68E7 1.04 1.5288 0.9992 3189259 PK04_101065 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D02 compound treatment 1.86494468E8 1.68E7 0.44 1.52302815E8 945000.0 0.03 0.329 0.7487 3069687 PK04_101066 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5ccc(CCO)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D03 compound treatment 1.84138767E8 1.44E7 0.38 1.54563335E8 3210000.0 0.09 0.3305 0.8524 3189260 PK04_101067 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D04 compound treatment 1.68082194E8 -1650000.0 -0.04 1.546022E8 3240000.0 0.09 0.034 0.3365 3069688 PK04_101068 OCCc1ccc(cc1)N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D05 compound treatment 1.67639777E8 -2100000.0 -0.05 1.48700383E8 -2660000.0 -0.07 -0.0917 -0.9883 3069732 PK04_101069 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D06 compound treatment 1.74440044E8 4700000.0 0.12 1.5474046E8 3380000.0 0.1 0.1545 0.992 3189139 PK04_101070 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D07 compound treatment 1.66512155E8 -3220000.0 -0.08 1.61593153E8 1.02E7 0.29 0.1443 0.4801 3189261 PK04_101071 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D08 compound treatment 1.59193573E8 -1.05E7 -0.28 1.56218205E8 4860000.0 0.14 -0.0983 -0.319 3069733 PK04_101072 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D09 compound treatment 1.67770358E8 -1970000.0 -0.05 1.49234168E8 -2120000.0 -0.06 -0.0787 -0.9972 3189262 PK04_101073 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D10 compound treatment 1.61595614E8 -8140000.0 -0.21 1.40766121E8 -1.06E7 -0.3 -0.3617 -0.9864 3069733 PK04_101074 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D11 mock treatment 1.60909746E8 -8830000.0 -0.23 1.52059983E8 703000.0 0.02 -0.1494 -0.6442 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D12 mock treatment 1.74343265E8 4610000.0 0.12 1.50048471E8 -1310000.0 -0.04 0.0592 0.4694 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D13 compound treatment 1.79937931E8 1.02E7 0.27 1.53770212E8 2410000.0 0.07 0.2369 0.8597 3189263 PK04_101075 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D14 compound treatment 1.57325799E8 -1.24E7 -0.32 1.37842015E8 -1.35E7 -0.38 -0.499 -0.9969 3069734 PK04_101076 CC(C)(C)N(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D15 mock treatment 1.71797066E8 2060000.0 0.05 1.46079524E8 -5280000.0 -0.15 -0.067 -0.4236 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D16 mock treatment 1.77454274E8 7720000.0 0.2 1.57143689E8 5790000.0 0.16 0.2582 0.9943 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D17 compound treatment 1.64799033E8 -4940000.0 -0.13 1.5278414E8 1430000.0 0.04 -0.063 -0.4651 3189264 PK04_101077 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D18 compound treatment 1.68768835E8 -967000.0 -0.03 1.56392445E8 5030000.0 0.14 0.0824 0.5719 3069734 PK04_101078 CC(C)(C)N(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D19 compound treatment 1.71941724E8 2210000.0 0.06 1.64520032E8 1.32E7 0.37 0.3031 0.8075 3069735 PK04_101079 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D20 compound treatment 1.764477E8 6710000.0 0.18 1.54188086E8 2830000.0 0.08 0.1806 0.9362 3189265 PK04_101080 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCOCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D21 compound treatment 1.74176652E8 4440000.0 0.12 1.59169302E8 7810000.0 0.22 0.2379 0.9555 3189266 PK04_101081 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D22 compound treatment 1.76030314E8 6290000.0 0.16 1.6531719E8 1.4E7 0.39 0.3947 0.9254 3189265 PK04_101082 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCOCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D23 compound treatment 1.81685297E8 1.19E7 0.31 1.68910959E8 1.76E7 0.49 0.571 0.9756 3069736 PK04_101083 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 D24 compound treatment 2.17034627E8 4.73E7 1.24 2.0981356E8 5.85E7 1.65 2.0403 0.9901 3189267 PK04_101084 OCCOCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E01 mock treatment 2.10214416E8 4.05E7 1.06 1.85073243E8 3.37E7 0.95 1.4211 0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E02 mock treatment 1.99815956E8 3.01E7 0.79 1.66495497E8 1.51E7 0.43 0.8584 0.9586 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E03 compound treatment 1.9093019E8 2.12E7 0.55 1.65747357E8 1.44E7 0.41 0.679 0.9881 3189373 PK04_101085 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E04 compound treatment 1.83148306E8 1.34E7 0.35 1.6129758E8 9940000.0 0.28 0.4463 0.9937 3189374 PK04_101086 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E05 compound treatment 1.70827548E8 1090000.0 0.03 1.57128091E8 5770000.0 0.16 0.1352 0.8188 3069761 PK04_101087 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E06 compound treatment 1.70740415E8 1000000.0 0.03 1.52712439E8 1350000.0 0.04 0.0456 0.9834 3189375 PK04_101088 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E07 compound treatment 1.57833084E8 -1.19E7 -0.31 1.49573025E8 -1780000.0 -0.05 -0.2559 -0.8107 3189376 PK04_101089 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E08 compound treatment 1.69210387E8 -526000.0 -0.01 1.59307659E8 7950000.0 0.22 0.1487 0.6624 3069762 PK04_101090 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E09 mock treatment 1.64875836E8 -4860000.0 -0.13 1.48511617E8 -2850000.0 -0.08 -0.1467 -0.9752 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E10 mock treatment 1.63859106E8 -5880000.0 -0.15 1.51278275E8 -79200.0 0.0 -0.1104 -0.7173 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E11 compound treatment 1.61185001E8 -8550000.0 -0.22 1.45600843E8 -5760000.0 -0.16 -0.273 -0.9875 3189377 PK04_101091 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E12 compound treatment 1.71680884E8 1940000.0 0.05 1.51242315E8 -115000.0 0.0 0.0337 0.6607 3069763 PK04_101092 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E13 compound treatment 1.70002551E8 267000.0 0.01 1.49390205E8 -1970000.0 -0.06 -0.0343 -0.6133 3189378 PK04_101093 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E14 compound treatment 1.78516023E8 8780000.0 0.23 1.54380599E8 3020000.0 0.09 0.2228 0.9088 3189379 PK04_101094 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E15 compound treatment 1.61251829E8 -8480000.0 -0.22 1.51804635E8 447000.0 0.01 -0.1481 -0.6659 3069764 PK04_101095 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E16 compound treatment 1.64339674E8 -5400000.0 -0.14 1.5429102E8 2930000.0 0.08 -0.0414 -0.2531 3189380 PK04_101096 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E17 mock treatment 1.75291142E8 5560000.0 0.15 1.55473328E8 4120000.0 0.12 0.1848 0.9937 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E18 mock treatment 1.78858507E8 9120000.0 0.24 1.63132901E8 1.18E7 0.33 0.4035 0.987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E19 compound treatment 1.86773471E8 1.7E7 0.45 1.65564876E8 1.42E7 0.4 0.5985 0.9986 3069765 PK04_101097 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E20 compound treatment 1.83064145E8 1.33E7 0.35 1.69066359E8 1.77E7 0.5 0.5996 0.9847 3189381 PK04_101098 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E21 compound treatment 1.81051435E8 1.13E7 0.3 1.61252941E8 9900000.0 0.28 0.4066 0.9995 3189382 PK04_101099 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E22 compound treatment 1.99493906E8 2.98E7 0.78 1.80659008E8 2.93E7 0.83 1.1347 0.9996 3069730 PK04_101100 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E23 compound treatment 1.82229056E8 1.25E7 0.33 1.71533048E8 2.02E7 0.57 0.6333 0.9655 3069766 PK04_101101 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 E24 compound treatment 2.33946244E8 6.42E7 1.68 2.0876767E8 5.74E7 1.62 2.3325 0.9998 3069731 PK04_101102 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F01 mock treatment 2.18779815E8 4.9E7 1.28 1.86832543E8 3.55E7 1.0 1.6147 0.9923 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F02 mock treatment 1.9487958E8 2.51E7 0.66 1.67883619E8 1.65E7 0.47 0.7947 0.9857 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F03 compound treatment 1.71218557E8 1480000.0 0.04 1.64836486E8 1.35E7 0.38 0.296 0.7753 3189383 PK04_101103 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F04 compound treatment 1.77124394E8 7390000.0 0.19 1.5706283E8 5710000.0 0.16 0.2504 0.9958 3189267 PK04_101104 OCCOCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F05 compound treatment 1.6893967E8 -796000.0 -0.02 1.48844629E8 -2510000.0 -0.07 -0.0648 -0.878 3189384 PK04_101105 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F06 compound treatment 1.57353844E8 -1.24E7 -0.32 1.45546003E8 -5810000.0 -0.16 -0.345 -0.95 3069767 PK04_101106 CCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F07 compound treatment 1.6825107E8 -1480000.0 -0.04 1.51991507E8 634000.0 0.02 -0.0149 -0.3471 3189385 PK04_101107 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F08 compound treatment 1.58326237E8 -1.14E7 -0.3 1.51149354E8 -208000.0 -0.01 -0.2153 -0.7209 3069767 PK04_101108 CCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F09 mock treatment 1.63444744E8 -6290000.0 -0.16 1.49017615E8 -2340000.0 -0.07 -0.1631 -0.9193 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F10 mock treatment 1.5741493E8 -1.23E7 -0.32 1.46672473E8 -4680000.0 -0.13 -0.3214 -0.9223 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F11 compound treatment 1.53655874E8 -1.61E7 -0.42 1.48048498E8 -3310000.0 -0.09 -0.3636 -0.8433 3069768 PK04_101109 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F12 compound treatment 1.62909187E8 -6830000.0 -0.18 1.41890621E8 -9470000.0 -0.27 -0.315 -0.981 3189386 PK04_101110 CCCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F13 compound treatment 1.60203372E8 -9530000.0 -0.25 1.45801793E8 -5560000.0 -0.16 -0.2872 -0.9748 3189387 PK04_101111 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F14 compound treatment 1.6785234E8 -1880000.0 -0.05 1.51333785E8 -23700.0 0.0 -0.0353 -0.7166 3189386 PK04_101112 CCCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F15 compound treatment 1.68577029E8 -1160000.0 -0.03 1.53142446E8 1780000.0 0.05 0.0141 0.2403 3069769 PK04_101113 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F16 compound treatment 1.59829009E8 -9910000.0 -0.26 1.47765644E8 -3590000.0 -0.1 -0.2549 -0.9158 3189388 PK04_101114 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F17 mock treatment 1.77417426E8 7680000.0 0.2 1.55985438E8 4630000.0 0.13 0.2344 0.978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F18 mock treatment 1.80652136E8 1.09E7 0.29 1.5741636E8 6060000.0 0.17 0.3228 0.9697 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F19 compound treatment 1.81553992E8 1.18E7 0.31 1.62531502E8 1.12E7 0.31 0.4414 1.0 3189389 PK04_101115 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F20 compound treatment 1.88612025E8 1.89E7 0.49 1.66041836E8 1.47E7 0.41 0.642 0.9961 3189388 PK04_101116 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F21 compound treatment 1.77908314E8 8170000.0 0.21 1.61028721E8 9670000.0 0.27 0.344 0.9928 3069770 PK04_101117 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F22 compound treatment 1.80187368E8 1.05E7 0.27 1.66522423E8 1.52E7 0.43 0.4956 0.9768 3189390 PK04_101118 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F23 compound treatment 1.95186918E8 2.55E7 0.67 1.82151528E8 3.08E7 0.87 1.0847 0.9915 3189391 PK04_101119 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 F24 compound treatment 2.32698846E8 6.3E7 1.65 2.09414981E8 5.81E7 1.64 2.3223 1.0 3189390 PK04_101120 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G01 compound treatment 2.12524308E8 4.28E7 1.12 1.87929925E8 3.66E7 1.03 1.5208 0.9991 3189392 PK04_101121 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G02 compound treatment 1.99556487E8 2.98E7 0.78 1.70381397E8 1.9E7 0.54 0.9311 0.9832 3189374 PK04_101122 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G03 mock treatment 1.8912091E8 1.94E7 0.51 1.64438043E8 1.31E7 0.37 0.6195 0.9877 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G04 mock treatment 1.8199255E8 1.23E7 0.32 1.5856916E8 7210000.0 0.2 0.3706 0.9757 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G05 compound treatment 1.73794763E8 4060000.0 0.11 1.5691775E8 5560000.0 0.16 0.1859 0.9821 3069794 PK04_101123 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G06 compound treatment 1.75043332E8 5310000.0 0.14 1.54271156E8 2910000.0 0.08 0.1563 0.9685 3189375 PK04_101124 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G07 compound treatment 1.65089871E8 -4650000.0 -0.12 1.54075488E8 2720000.0 0.08 -0.0318 -0.2215 3189393 PK04_101125 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G08 compound treatment 1.65135309E8 -4600000.0 -0.12 1.50262583E8 -1090000.0 -0.03 -0.107 -0.8605 3069762 PK04_101126 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G09 compound treatment 1.56657885E8 -1.31E7 -0.34 1.50954508E8 -403000.0 -0.01 -0.2501 -0.7302 3069795 PK04_101127 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G10 compound treatment 1.61110763E8 -8630000.0 -0.23 1.48287623E8 -3070000.0 -0.09 -0.2208 -0.9133 3069763 PK04_101128 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G11 compound treatment 1.59020109E8 -1.07E7 -0.28 1.42178995E8 -9180000.0 -0.26 -0.3812 -0.9992 3189504 PK04_101129 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G12 compound treatment 1.55213203E8 -1.45E7 -0.38 1.43363854E8 -7990000.0 -0.23 -0.4281 -0.9688 3189379 PK04_101130 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G13 compound treatment 1.65981407E8 -3750000.0 -0.1 1.45906171E8 -5450000.0 -0.15 -0.1781 -0.9767 3069796 PK04_101131 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G14 compound treatment 1.70631425E8 895000.0 0.02 1.4976703E8 -1590000.0 -0.04 -0.0151 -0.2989 3189380 PK04_101132 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G15 compound treatment 1.59192587E8 -1.05E7 -0.28 1.46670671E8 -4690000.0 -0.13 -0.2885 -0.9431 3189505 PK04_101133 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G16 compound treatment 1.66793477E8 -2940000.0 -0.08 1.53146809E8 1790000.0 0.05 -0.0188 -0.2043 3189381 PK04_101134 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G17 compound treatment 1.84296471E8 1.46E7 0.38 1.59906412E8 8550000.0 0.24 0.4399 0.9755 3189506 PK04_101135 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G18 compound treatment 1.78345493E8 8610000.0 0.23 1.60362246E8 9000000.0 0.25 0.3388 0.9982 3069797 PK04_101136 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G19 mock treatment 1.7865666E8 8920000.0 0.23 1.65095566E8 1.37E7 0.39 0.4389 0.9707 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G20 mock treatment 1.88287014E8 1.86E7 0.49 1.64092746E8 1.27E7 0.36 0.5971 0.9889 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G21 compound treatment 1.95249753E8 2.55E7 0.67 1.66980103E8 1.56E7 0.44 0.7836 0.9795 3189507 PK04_101137 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G22 compound treatment 2.04908263E8 3.52E7 0.92 1.79417324E8 2.81E7 0.79 1.2102 0.9971 3189508 PK04_101138 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G23 compound treatment 2.0611782E8 3.64E7 0.95 1.80353779E8 2.9E7 0.82 1.2512 0.9971 3069798 PK04_101139 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 G24 compound treatment 2.34370807E8 6.46E7 1.69 2.01642761E8 5.03E7 1.42 2.1984 0.9961 3189509 PK04_101140 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H01 compound treatment 2.11095373E8 4.14E7 1.08 1.80811501E8 2.95E7 0.83 1.3525 0.9914 3069799 PK04_101141 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H02 compound treatment 1.79071015E8 9340000.0 0.24 1.56346378E8 4990000.0 0.14 0.2722 0.9655 3189510 PK04_101142 CC(C)(CO)N1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H03 mock treatment 1.85746425E8 1.6E7 0.42 1.63530064E8 1.22E7 0.34 0.5389 0.9951 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H04 mock treatment 1.746574E8 4920000.0 0.13 1.53715738E8 2360000.0 0.07 0.1381 0.9526 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H05 compound treatment 1.67780018E8 -1960000.0 -0.05 1.37743553E8 -1.36E7 -0.38 -0.3075 -0.7944 3189511 PK04_101143 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H06 compound treatment 1.63139139E8 -6600000.0 -0.17 1.49561752E8 -1800000.0 -0.05 -0.1579 -0.8774 3069800 PK04_101144 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H07 compound treatment 1.70065444E8 329000.0 0.01 1.52769134E8 1410000.0 0.04 0.0342 0.8409 3189512 PK04_101145 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H08 compound treatment 1.58011377E8 -1.17E7 -0.31 1.44018222E8 -7340000.0 -0.21 -0.3633 -0.9815 3069800 PK04_101146 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H09 compound treatment 1.65467336E8 -4270000.0 -0.11 1.47018552E8 -4340000.0 -0.12 -0.1655 -0.999 3189513 PK04_101147 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H10 compound treatment 1.61377347E8 -8360000.0 -0.22 1.41076925E8 -1.03E7 -0.29 -0.3596 -0.9904 3189510 PK04_101148 CC(C)(CO)N1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H11 compound treatment 1.51679379E8 -1.81E7 -0.47 1.35412567E8 -1.59E7 -0.45 -0.6519 -0.9997 3069801 PK04_101149 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H12 compound treatment 1.53753171E8 -1.6E7 -0.42 1.37868214E8 -1.35E7 -0.38 -0.5646 -0.9989 3189514 PK04_101150 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H13 compound treatment 1.58042499E8 -1.17E7 -0.31 1.41883546E8 -9470000.0 -0.27 -0.4052 -0.9977 3189515 PK04_101151 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H14 compound treatment 1.66361219E8 -3370000.0 -0.09 1.45849796E8 -5510000.0 -0.16 -0.1722 -0.9643 3189514 PK04_101152 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H15 compound treatment 1.72623583E8 2890000.0 0.08 1.51502721E8 145000.0 0.0 0.0563 0.7443 3069802 PK04_101153 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H16 compound treatment 1.70586579E8 851000.0 0.02 1.53318732E8 1960000.0 0.06 0.0548 0.9201 3189516 PK04_101154 CC(C)(C)N(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H17 compound treatment 1.80203718E8 1.05E7 0.27 1.58204071E8 6850000.0 0.19 0.3302 0.9853 3189517 PK04_101155 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H18 compound treatment 1.76531289E8 6800000.0 0.18 1.60330868E8 8970000.0 0.25 0.3046 0.9852 3189516 PK04_101156 CC(C)(C)N(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H19 mock treatment 1.74461311E8 4730000.0 0.12 1.64581145E8 1.32E7 0.37 0.351 0.8939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H20 mock treatment 1.78276108E8 8540000.0 0.22 1.6207682E8 1.07E7 0.3 0.3717 0.989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H21 compound treatment 1.85840932E8 1.61E7 0.42 1.6373431E8 1.24E7 0.35 0.5447 0.9956 3069803 PK04_101157 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H22 compound treatment 1.80266564E8 1.05E7 0.28 1.69736125E8 1.84E7 0.52 0.5611 0.9564 3189518 PK04_101158 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCCCCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H23 compound treatment 2.03347639E8 3.36E7 0.88 1.82339011E8 3.1E7 0.87 1.2395 1.0 3069804 PK04_101159 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 H24 compound treatment 2.32939654E8 6.32E7 1.65 2.00698361E8 4.93E7 1.39 2.1531 0.9963 3189518 PK04_101160 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCCCCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I01 compound treatment 2.07092253E8 3.74E7 0.98 1.83225847E8 3.19E7 0.9 1.3265 0.9991 3189519 PK04_101161 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I02 compound treatment 2.00173712E8 3.04E7 0.8 1.59450429E8 8090000.0 0.23 0.7247 0.8744 3189520 PK04_101162 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I03 compound treatment 1.68477711E8 -1260000.0 -0.03 1.56634111E8 5280000.0 0.15 0.0819 0.5375 3069839 PK04_101163 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I04 compound treatment 1.70795757E8 1060000.0 0.03 1.60417629E8 9060000.0 0.26 0.2002 0.7794 3189521 PK04_101164 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I05 mock treatment 1.66622514E8 -3110000.0 -0.08 1.49981592E8 -1380000.0 -0.04 -0.085 -0.9423 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I06 mock treatment 1.69316249E8 -420000.0 -0.01 1.4942985E8 -1930000.0 -0.05 -0.0462 -0.8332 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I07 compound treatment 1.67293795E8 -2440000.0 -0.06 1.49409333E8 -1950000.0 -0.05 -0.084 -0.9971 3069840 PK04_101165 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I08 compound treatment 1.61447456E8 -8290000.0 -0.22 1.39916059E8 -1.14E7 -0.32 -0.3814 -0.9814 3189522 PK04_101166 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I09 compound treatment 1.59558765E8 -1.02E7 -0.27 1.43418168E8 -7940000.0 -0.22 -0.3466 -0.9962 3189523 PK04_101167 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I10 compound treatment 1.54796713E8 -1.49E7 -0.39 1.41591369E8 -9770000.0 -0.28 -0.4711 -0.9852 3069841 PK04_101168 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I11 compound treatment 1.50726235E8 -1.9E7 -0.5 1.39000181E8 -1.24E7 -0.35 -0.5981 -0.9848 3189524 PK04_101169 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I12 compound treatment 1.57498877E8 -1.22E7 -0.32 1.40063245E8 -1.13E7 -0.32 -0.4516 -1.0 3189640 PK04_101170 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I13 compound treatment 1.47595209E8 -2.21E7 -0.58 1.35068526E8 -1.63E7 -0.46 -0.7344 -0.9933 3069842 PK04_101171 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I14 compound treatment 1.60281023E8 -9450000.0 -0.25 1.48300736E8 -3060000.0 -0.09 -0.2359 -0.9002 3189641 PK04_101172 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I15 compound treatment 1.6929542E8 -441000.0 -0.01 1.53801454E8 2440000.0 0.07 0.0405 0.5806 3069843 PK04_101173 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I16 compound treatment 1.73399509E8 3660000.0 0.1 1.5313716E8 1780000.0 0.05 0.1033 0.9543 3189642 PK04_101174 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I17 compound treatment 1.66812173E8 -2920000.0 -0.08 1.53829073E8 2470000.0 0.07 -0.0049 -0.047 3069844 PK04_101175 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I18 compound treatment 1.71972037E8 2240000.0 0.06 1.52453731E8 1100000.0 0.03 0.0632 0.9554 3189643 PK04_101176 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I19 compound treatment 1.78374207E8 8640000.0 0.23 1.62663896E8 1.13E7 0.32 0.3852 0.9859 3069845 PK04_101177 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I20 compound treatment 1.81379592E8 1.16E7 0.3 1.65363422E8 1.4E7 0.39 0.4946 0.9918 3189644 PK04_101178 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I21 mock treatment 1.82076157E8 1.23E7 0.32 1.65238699E8 1.39E7 0.39 0.505 0.9955 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I22 mock treatment 1.83615381E8 1.39E7 0.36 1.69993948E8 1.86E7 0.53 0.6283 0.9838 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I23 compound treatment 2.04303864E8 3.46E7 0.9 1.83259858E8 3.19E7 0.9 1.2755 1.0 3189645 PK04_101179 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 I24 compound treatment 2.33209347E8 6.35E7 1.66 2.09234811E8 5.79E7 1.63 2.3282 1.0 3069846 PK04_101180 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J01 compound treatment 2.08761152E8 3.9E7 1.02 1.82009537E8 3.07E7 0.86 1.3331 0.9965 3189646 PK04_101181 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J02 compound treatment 1.90343792E8 2.06E7 0.54 1.55289614E8 3930000.0 0.11 0.4598 0.8349 3189647 PK04_101182 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J03 compound treatment 1.87398234E8 1.77E7 0.46 1.47037349E8 -4320000.0 -0.12 0.2408 0.5037 3069847 PK04_101183 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J04 compound treatment 1.78686987E8 8950000.0 0.23 1.41888179E8 -9470000.0 -0.27 -0.023 -0.0648 3189647 PK04_101184 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J05 mock treatment 1.60239279E8 -9500000.0 -0.25 1.46674405E8 -4680000.0 -0.13 -0.2691 -0.9561 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J06 mock treatment 1.5689434E8 -1.28E7 -0.34 1.47034493E8 -4320000.0 -0.12 -0.3238 -0.9057 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J07 compound treatment 1.49983426E8 -1.98E7 -0.52 1.34489986E8 -1.69E7 -0.48 -0.7017 -0.9991 3189648 PK04_101185 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J08 compound treatment 1.55040614E8 -1.47E7 -0.38 1.45737896E8 -5620000.0 -0.16 -0.384 -0.923 3189649 PK04_101186 CCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J09 compound treatment 1.52165103E8 -1.76E7 -0.46 1.41421003E8 -9940000.0 -0.28 -0.5232 -0.9717 3069848 PK04_101187 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J10 compound treatment 1.44338794E8 -2.54E7 -0.66 1.28582228E8 -2.28E7 -0.64 -0.9239 -0.9998 3189649 PK04_101188 CCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J11 compound treatment 1.53738807E8 -1.6E7 -0.42 1.35334796E8 -1.6E7 -0.45 -0.6154 -0.9993 3189650 PK04_101189 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J12 compound treatment 1.47437445E8 -2.23E7 -0.58 1.37452474E8 -1.39E7 -0.39 -0.6898 -0.9812 3189651 PK04_101190 CCCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J13 compound treatment 1.4878277E8 -2.1E7 -0.55 1.35429268E8 -1.59E7 -0.45 -0.7052 -0.995 3069849 PK04_101191 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J14 compound treatment 1.5717644E8 -1.26E7 -0.33 1.41157871E8 -1.02E7 -0.29 -0.4357 -0.9978 3189651 PK04_101192 CCCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J15 compound treatment 1.60877427E8 -8860000.0 -0.23 1.48845893E8 -2510000.0 -0.07 -0.214 -0.8827 3189652 PK04_101193 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J16 compound treatment 1.30920816E8 -3.88E7 -1.02 1.18190966E8 -3.32E7 -0.93 -1.3794 -0.9991 3069850 PK04_101194 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J17 compound treatment 1.66456258E8 -3280000.0 -0.09 1.52361046E8 1000000.0 0.03 -0.0407 -0.4504 3189653 PK04_101195 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J18 compound treatment 1.63569704E8 -6170000.0 -0.16 1.50310474E8 -1050000.0 -0.03 -0.135 -0.8227 3069850 PK04_101196 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J19 compound treatment 1.6351558E8 -6220000.0 -0.16 1.52775958E8 1420000.0 0.04 -0.0869 -0.5181 3189654 PK04_101197 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J20 compound treatment 1.77481196E8 7750000.0 0.2 1.56951856E8 5590000.0 0.16 0.2548 0.9923 3069851 PK04_101198 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2c(Cl)cccc2CO)c3cccs3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J21 mock treatment 1.8033493E8 1.06E7 0.28 1.65603753E8 1.42E7 0.4 0.4801 0.9837 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J22 mock treatment 1.91156975E8 2.14E7 0.56 1.75873048E8 2.45E7 0.69 0.885 0.9946 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J23 compound treatment 2.10591769E8 4.09E7 1.07 1.8715552E8 3.58E7 1.01 1.4696 0.9996 3189655 PK04_101199 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 J24 compound treatment 2.30265415E8 6.05E7 1.58 2.04657421E8 5.33E7 1.5 2.1825 0.9996 3069851 PK04_101200 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2c(Cl)cccc2CO)c3cccs3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K01 compound treatment 2.24812468E8 5.51E7 1.44 1.88650727E8 3.73E7 1.05 1.7626 0.9879 3189656 PK04_101201 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K02 compound treatment 1.80339539E8 1.06E7 0.28 1.63081407E8 1.17E7 0.33 0.4299 0.9962 3189657 PK04_101202 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K03 compound treatment 1.67947399E8 -1790000.0 -0.05 1.41298474E8 -1.01E7 -0.28 -0.2335 -0.8129 3069890 PK04_101203 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K04 compound treatment 1.76269257E8 6530000.0 0.17 1.47722993E8 -3630000.0 -0.1 0.0485 0.2433 3189658 PK04_101204 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCC(C)OC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K05 compound treatment 1.60241334E8 -9490000.0 -0.25 1.43197908E8 -8160000.0 -0.23 -0.3383 -0.9992 3069891 PK04_101205 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K06 compound treatment 1.52716243E8 -1.7E7 -0.45 1.30989718E8 -2.04E7 -0.57 -0.7209 -0.9922 3189659 PK04_101206 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K07 mock treatment 1.48700341E8 -2.1E7 -0.55 1.35372822E8 -1.6E7 -0.45 -0.7079 -0.995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K08 mock treatment 1.54145427E8 -1.56E7 -0.41 1.43371879E8 -7990000.0 -0.23 -0.4477 -0.9606 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K09 compound treatment 1.49838204E8 -1.99E7 -0.52 1.36289075E8 -1.51E7 -0.42 -0.6686 -0.9949 3187684 PK04_101207 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K10 compound treatment 1.43763013E8 -2.6E7 -0.68 1.37818418E8 -1.35E7 -0.38 -0.7505 -0.9627 3069892 PK04_101208 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K11 compound treatment 1.48745209E8 -2.1E7 -0.55 1.34303273E8 -1.71E7 -0.48 -0.7284 -0.9978 3187685 PK04_101209 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K12 compound treatment 1.48660434E8 -2.11E7 -0.55 1.34076896E8 -1.73E7 -0.49 -0.7344 -0.9981 3187686 PK04_101210 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K13 compound treatment 1.52697691E8 -1.7E7 -0.45 1.34247857E8 -1.71E7 -0.48 -0.6563 -0.9992 3069893 PK04_101211 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K14 compound treatment 1.53758954E8 -1.6E7 -0.42 1.43500439E8 -7860000.0 -0.22 -0.4523 -0.9558 3187687 PK04_101212 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K15 mock treatment 1.58279178E8 -1.15E7 -0.3 1.40491222E8 -1.09E7 -0.31 -0.4286 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K16 mock treatment 1.64885924E8 -4850000.0 -0.13 1.50500914E8 -857000.0 -0.02 -0.1068 -0.8267 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K17 compound treatment 1.64097089E8 -5640000.0 -0.15 1.56414138E8 5060000.0 0.14 -0.0036 -0.0176 3069894 PK04_101213 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K18 compound treatment 1.69197895E8 -538000.0 -0.01 1.51485039E8 128000.0 0.0 -0.0074 -0.5102 3187688 PK04_101214 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K19 compound treatment 1.788131E8 9080000.0 0.24 1.54910872E8 3550000.0 0.1 0.2388 0.9262 3069895 PK04_101215 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K20 compound treatment 1.86519921E8 1.68E7 0.44 1.65130248E8 1.38E7 0.39 0.5851 0.9981 3187689 PK04_101216 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K21 compound treatment 1.89887442E8 2.02E7 0.53 1.71568423E8 2.02E7 0.57 0.7757 0.9993 3187690 PK04_101217 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K22 compound treatment 1.79087467E8 9350000.0 0.24 1.66426068E8 1.51E7 0.42 0.4734 0.9658 3069896 PK04_101218 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K23 mock treatment 1.90432512E8 2.07E7 0.54 1.73260837E8 2.19E7 0.62 0.8195 0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 K24 mock treatment 2.27752084E8 5.8E7 1.52 2.07080118E8 5.57E7 1.57 2.1842 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L01 compound treatment 1.95139269E8 2.54E7 0.66 1.78679703E8 2.73E7 0.77 1.0146 0.9973 3187691 PK04_101219 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L02 compound treatment 1.80070743E8 1.03E7 0.27 1.53946176E8 2590000.0 0.07 0.2429 0.8668 3187692 PK04_101220 OCc1cccc(Cl)c1N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L03 compound treatment 1.83455563E8 1.37E7 0.36 1.60504378E8 9150000.0 0.26 0.4362 0.9868 3069897 PK04_101221 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L04 compound treatment 1.6038556E8 -9350000.0 -0.24 1.33035174E8 -1.83E7 -0.52 -0.5382 -0.9418 3187693 PK04_101222 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L05 compound treatment 1.70995928E8 1260000.0 0.03 1.53128529E8 1770000.0 0.05 0.0586 0.9798 3187694 PK04_101223 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L06 compound treatment 1.65583997E8 -4150000.0 -0.11 1.39609284E8 -1.17E7 -0.33 -0.311 -0.8924 3187693 PK04_101224 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L07 mock treatment 1.53540679E8 -1.62E7 -0.42 1.40003757E8 -1.14E7 -0.32 -0.526 -0.9904 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L08 mock treatment 1.5653901E8 -1.32E7 -0.35 1.4070751E8 -1.06E7 -0.3 -0.4565 -0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L09 compound treatment 1.52748837E8 -1.7E7 -0.44 1.3597457E8 -1.54E7 -0.43 -0.621 -0.9999 3069898 PK04_101225 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L10 compound treatment 1.49721937E8 -2.0E7 -0.52 1.3658509E8 -1.48E7 -0.42 -0.6648 -0.9935 3187692 PK04_101226 OCc1cccc(Cl)c1N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L11 compound treatment 1.29874602E8 -3.99E7 -1.04 1.17138431E8 -3.42E7 -0.96 -1.4197 -0.9992 3187695 PK04_101227 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L12 compound treatment 1.42048775E8 -2.77E7 -0.72 1.34035129E8 -1.73E7 -0.49 -0.8577 -0.9815 3187696 PK04_101228 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L13 compound treatment 1.48803426E8 -2.09E7 -0.55 1.24828273E8 -2.65E7 -0.75 -0.9161 -0.9883 3069899 PK04_101229 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L14 compound treatment 1.47282875E8 -2.25E7 -0.59 1.41955746E8 -9400000.0 -0.26 -0.6029 -0.9352 3187696 PK04_101230 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L15 mock treatment 1.53475968E8 -1.63E7 -0.43 1.38848627E8 -1.25E7 -0.35 -0.5502 -0.9956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L16 mock treatment 1.55144014E8 -1.46E7 -0.38 1.39294251E8 -1.21E7 -0.34 -0.5105 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L17 compound treatment 1.67351965E8 -2380000.0 -0.06 1.55362891E8 4010000.0 0.11 0.0357 0.2767 3187697 PK04_101231 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L18 compound treatment 1.62356272E8 -7380000.0 -0.19 1.53217305E8 1860000.0 0.05 -0.0995 -0.4973 3187698 PK04_101232 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L19 compound treatment 1.71884438E8 2150000.0 0.06 1.53570574E8 2210000.0 0.06 0.0839 0.9987 3069900 PK04_101233 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L20 compound treatment 1.71716839E8 1980000.0 0.05 1.5810325E8 6750000.0 0.19 0.1711 0.8683 3187698 PK04_101234 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L21 compound treatment 1.734299E8 3690000.0 0.1 1.54063748E8 2710000.0 0.08 0.1223 0.9931 3187699 PK04_101235 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L22 compound treatment 1.72712756E8 2980000.0 0.08 1.58148268E8 6790000.0 0.19 0.1904 0.9216 3187700 PK04_101236 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2ccc(CCO)cc2)c3cccs3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L23 mock treatment 1.98821056E8 2.91E7 0.76 1.78656802E8 2.73E7 0.77 1.0823 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 L24 mock treatment 2.16792314E8 4.71E7 1.23 2.00724258E8 4.94E7 1.39 1.8547 0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M01 compound treatment 2.173041E8 4.76E7 1.25 1.95144941E8 4.38E7 1.23 1.753 1.0 3187701 PK04_101237 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M02 compound treatment 1.80551962E8 1.08E7 0.28 1.62863481E8 1.15E7 0.32 0.4295 0.9977 3069926 PK04_101238 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M03 compound treatment 1.74502849E8 4770000.0 0.12 1.51753186E8 396000.0 0.01 0.0961 0.7672 3187702 PK04_101239 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M04 compound treatment 1.61396992E8 -8340000.0 -0.22 1.34743449E8 -1.66E7 -0.47 -0.4854 -0.9397 3069927 PK04_101240 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M05 compound treatment 1.7504212E8 5310000.0 0.14 1.52643634E8 1290000.0 0.04 0.1238 0.8627 3187703 PK04_101241 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M06 compound treatment 1.55980452E8 -1.38E7 -0.36 1.28549714E8 -2.28E7 -0.64 -0.7091 -0.9625 3187824 PK04_101242 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCC(C)OC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M07 compound treatment 1.58240489E8 -1.15E7 -0.3 1.34392688E8 -1.7E7 -0.48 -0.5508 -0.9751 3069928 PK04_101243 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M08 compound treatment 1.58317653E8 -1.14E7 -0.3 1.42885969E8 -8470000.0 -0.24 -0.3802 -0.9938 3187825 PK04_101244 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M09 mock treatment 1.48121193E8 -2.16E7 -0.57 1.3758261E8 -1.38E7 -0.39 -0.6746 -0.9831 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M10 mock treatment 1.33749738E8 -3.6E7 -0.94 1.22516051E8 -2.88E7 -0.81 -1.2408 -0.9973 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M11 compound treatment 9.9646201E7 -7.01E7 -1.83 9.0009436E7 -6.13E7 -1.73 -2.5198 -0.9996 3187826 PK04_101245 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M12 compound treatment 1.44282066E8 -2.55E7 -0.67 1.3157876E8 -1.98E7 -0.56 -0.8653 -0.9961 3069929 PK04_101246 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M13 mock treatment 1.45101857E8 -2.46E7 -0.64 1.34460859E8 -1.69E7 -0.48 -0.7927 -0.9889 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M14 mock treatment 1.37828335E8 -3.19E7 -0.84 1.29217465E8 -2.21E7 -0.62 -1.0318 -0.9897 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M15 compound treatment 1.51475456E8 -1.83E7 -0.48 1.37478392E8 -1.39E7 -0.39 -0.6146 -0.995 3187827 PK04_101247 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M16 compound treatment 1.48383072E8 -2.14E7 -0.56 1.31806296E8 -1.96E7 -0.55 -0.7848 -1.0 3187828 PK04_101248 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M17 compound treatment 1.61869115E8 -7870000.0 -0.21 1.46985327E8 -4370000.0 -0.12 -0.2327 -0.9698 3069930 PK04_101249 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M18 compound treatment 1.65882177E8 -3850000.0 -0.1 1.53245674E8 1890000.0 0.05 -0.0337 -0.2955 3187829 PK04_101250 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M19 compound treatment 1.6947222E8 -264000.0 -0.01 1.57274691E8 5920000.0 0.17 0.113 0.6773 3069931 PK04_101251 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M20 compound treatment 1.72701704E8 2970000.0 0.08 1.5003964E8 -1320000.0 -0.04 0.0286 0.3328 3187830 PK04_101252 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M21 compound treatment 1.94092008E8 2.44E7 0.64 1.76152425E8 2.48E7 0.7 0.9449 0.999 3187831 PK04_101253 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M22 compound treatment 1.78446399E8 8710000.0 0.23 1.57372673E8 6020000.0 0.17 0.2811 0.9893 3069932 PK04_101254 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M23 compound treatment 1.94459485E8 2.47E7 0.65 1.77452748E8 2.61E7 0.74 0.9776 0.998 3187832 PK04_101255 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 M24 compound treatment 2.21153828E8 5.14E7 1.35 2.01596769E8 5.02E7 1.42 1.9528 0.9997 3187833 PK04_101256 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N01 compound treatment 2.21089511E8 5.14E7 1.34 1.91664017E8 4.03E7 1.14 1.7537 0.9965 3069933 PK04_101257 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N02 compound treatment 1.95822054E8 2.61E7 0.68 1.73458554E8 2.21E7 0.62 0.9232 0.9989 3187700 PK04_101258 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2ccc(CCO)cc2)c3cccs3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N03 compound treatment 1.70936456E8 1200000.0 0.03 1.55917717E8 4560000.0 0.13 0.1131 0.8548 3187834 PK04_101259 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N04 compound treatment 1.63854527E8 -5880000.0 -0.15 1.43384121E8 -7970000.0 -0.22 -0.2677 -0.983 3069934 PK04_101260 OCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N05 compound treatment 1.62570094E8 -7170000.0 -0.19 1.44504639E8 -6850000.0 -0.19 -0.2692 -0.9999 3187835 PK04_101261 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N06 compound treatment 1.60529686E8 -9210000.0 -0.24 1.40163708E8 -1.12E7 -0.32 -0.3935 -0.9912 3069934 PK04_101262 OCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N07 compound treatment 1.5003948E8 -1.97E7 -0.52 1.33368805E8 -1.8E7 -0.51 -0.723 -1.0 3187836 PK04_101263 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N08 compound treatment 1.5149471E8 -1.82E7 -0.48 1.31769257E8 -1.96E7 -0.55 -0.728 -0.9974 3069935 PK04_101264 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N09 mock treatment 1.40657924E8 -2.91E7 -0.76 1.29605661E8 -2.18E7 -0.61 -0.9717 -0.9942 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N10 mock treatment 1.32158396E8 -3.76E7 -0.98 1.19677444E8 -3.17E7 -0.89 -1.3268 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N11 compound treatment 1.40476118E8 -2.93E7 -0.77 1.19324772E8 -3.2E7 -0.9 -1.1799 -0.9967 3187837 PK04_101265 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N12 compound treatment 1.41854182E8 -2.79E7 -0.73 1.32100664E8 -1.93E7 -0.54 -0.8998 -0.9894 3069935 PK04_101266 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N13 mock treatment 1.38038498E8 -3.17E7 -0.83 1.3299663E8 -1.84E7 -0.52 -0.9526 -0.9742 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N14 mock treatment 1.35778499E8 -3.4E7 -0.89 1.26573556E8 -2.48E7 -0.7 -1.1224 -0.9929 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N15 compound treatment 1.51778936E8 -1.8E7 -0.47 1.40764632E8 -1.06E7 -0.3 -0.5435 -0.976 3069936 PK04_101267 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N16 compound treatment 1.60746238E8 -8990000.0 -0.24 1.46119675E8 -5240000.0 -0.15 -0.2708 -0.9748 3187838 PK04_101268 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N17 compound treatment 1.7123452E8 1500000.0 0.04 1.44012846E8 -7340000.0 -0.21 -0.1186 -0.5631 3187839 PK04_101269 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N18 compound treatment 1.59892144E8 -9840000.0 -0.26 1.5656259E8 5210000.0 0.15 -0.0785 -0.2647 3187838 PK04_101270 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N19 compound treatment 1.65419203E8 -4320000.0 -0.11 1.55089389E8 3730000.0 0.11 -0.0055 -0.0359 3187840 PK04_101271 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N20 compound treatment 1.88402724E8 1.87E7 0.49 1.7096206E8 1.96E7 0.55 0.7362 0.9981 3187841 PK04_101272 CC(C)(C)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N21 compound treatment 1.78184943E8 8450000.0 0.22 1.66027134E8 1.47E7 0.41 0.4487 0.9571 3069973 PK04_101273 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N22 compound treatment 1.8213264E8 1.24E7 0.32 1.69204865E8 1.78E7 0.5 0.5851 0.9775 3187841 PK04_101274 CC(C)(C)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N23 compound treatment 1.98703327E8 2.9E7 0.76 1.8112518E8 2.98E7 0.84 1.1293 0.9987 3187842 PK04_101275 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 N24 compound treatment 2.25148233E8 5.54E7 1.45 2.0590978E8 5.46E7 1.54 2.1127 0.9996 3187843 PK04_101276 COc1ccc(cc1)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O01 compound treatment 2.17894734E8 4.82E7 1.26 1.96379958E8 4.5E7 1.27 1.7886 1.0 3069974 PK04_101277 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O02 compound treatment 1.8907703E8 1.93E7 0.51 1.75823018E8 2.45E7 0.69 0.8455 0.9885 3187957 PK04_101278 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O03 compound treatment 1.77753668E8 8020000.0 0.21 1.60889901E8 9530000.0 0.27 0.3384 0.9925 3187958 PK04_101279 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O04 compound treatment 1.66736355E8 -3000000.0 -0.08 1.480593E8 -3300000.0 -0.09 -0.1212 -0.9965 3069975 PK04_101280 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O05 compound treatment 1.66304997E8 -3430000.0 -0.09 1.55190365E8 3830000.0 0.11 0.0129 0.0916 3187959 PK04_101281 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O06 compound treatment 1.62211752E8 -7520000.0 -0.2 1.51095299E8 -262000.0 -0.01 -0.1445 -0.7331 3187960 PK04_101282 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O07 compound treatment 1.5672463E8 -1.3E7 -0.34 1.47160386E8 -4200000.0 -0.12 -0.3245 -0.8999 3069976 PK04_101283 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O08 compound treatment 1.44973076E8 -2.48E7 -0.65 1.27620821E8 -2.37E7 -0.67 -0.9313 -0.9999 3187961 PK04_101284 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O09 compound treatment 1.48480429E8 -2.13E7 -0.56 1.34925857E8 -1.64E7 -0.46 -0.7209 -0.9958 3069977 PK04_101285 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O10 compound treatment 1.39760709E8 -3.0E7 -0.78 1.29086844E8 -2.23E7 -0.63 -0.9986 -0.9939 3187962 PK04_101286 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O11 mock treatment 1.34604132E8 -3.51E7 -0.92 1.21933874E8 -2.94E7 -0.83 -1.2366 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O12 mock treatment 1.38113123E8 -3.16E7 -0.83 1.2776052E8 -2.36E7 -0.66 -1.0555 -0.9941 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O13 compound treatment 1.47217474E8 -2.25E7 -0.59 1.26605022E8 -2.48E7 -0.7 -0.91 -0.9965 3187963 PK04_101287 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O14 compound treatment 1.4401085E8 -2.57E7 -0.67 1.36954801E8 -1.44E7 -0.41 -0.7632 -0.9706 3069978 PK04_101288 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O15 compound treatment 1.50706104E8 -1.9E7 -0.5 1.4130273E8 -1.01E7 -0.28 -0.5526 -0.9642 3187964 PK04_101289 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O16 compound treatment 1.68005139E8 -1730000.0 -0.05 1.4180268E8 -9550000.0 -0.27 -0.2224 -0.8146 3187965 PK04_101290 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O17 compound treatment 1.75410915E8 5670000.0 0.15 1.61319466E8 9960000.0 0.28 0.3036 0.9557 3069979 PK04_101291 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O18 compound treatment 1.63520881E8 -6220000.0 -0.16 1.56712221E8 5350000.0 0.15 -0.0083 -0.0376 3187966 PK04_101292 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O19 compound treatment 1.69310765E8 -425000.0 -0.01 1.62450438E8 1.11E7 0.31 0.2132 0.6815 3187967 PK04_101293 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O20 compound treatment 1.68313876E8 -1420000.0 -0.04 1.60230638E8 8870000.0 0.25 0.1505 0.5953 3069980 PK04_101294 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O21 compound treatment 1.96848896E8 2.71E7 0.71 1.80556733E8 2.92E7 0.82 1.0837 0.9973 3187968 PK04_101295 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O22 compound treatment 1.84755456E8 1.5E7 0.39 1.76089103E8 2.47E7 0.7 0.7708 0.9633 3069981 PK04_101296 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O23 compound treatment 2.03179523E8 3.34E7 0.88 1.90305358E8 3.89E7 1.1 1.3951 0.9937 3187969 PK04_101297 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 O24 compound treatment 2.25510875E8 5.58E7 1.46 2.12672236E8 6.13E7 1.73 2.2542 0.9965 3187970 PK04_101298 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P01 compound treatment 2.33650883E8 6.39E7 1.67 2.15433101E8 6.41E7 1.81 2.4599 0.9993 3069982 PK04_101299 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P02 compound treatment 2.02383787E8 3.26E7 0.85 1.76460488E8 2.51E7 0.71 1.1045 0.9956 3187843 PK04_101300 COc1ccc(cc1)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P03 compound treatment 1.89794119E8 2.01E7 0.53 1.8206666E8 3.07E7 0.87 0.9832 0.9713 3187971 PK04_101301 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P04 compound treatment 1.80668547E8 1.09E7 0.29 1.63093802E8 1.17E7 0.33 0.4362 0.9974 3069983 PK04_101302 OCCOCCN(C(C(=O)N(CC=C)Cc1ccccc1)c2cccs2)C(=O)/C=C\C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P05 compound treatment 1.76040679E8 6300000.0 0.17 1.63745224E8 1.24E7 0.35 0.3635 0.9415 3187972 PK04_101303 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P06 compound treatment 1.61745928E8 -7990000.0 -0.21 1.54981885E8 3620000.0 0.1 -0.0757 -0.3251 3187973 PK04_101304 OCCOCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P07 compound treatment 1.68912109E8 -824000.0 -0.02 1.56457725E8 5100000.0 0.14 0.0864 0.5944 3069985 PK04_101305 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P08 compound treatment 1.52613102E8 -1.71E7 -0.45 1.49255837E8 -2100000.0 -0.06 -0.3588 -0.7936 3187974 PK04_101306 CCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P09 compound treatment 1.59685578E8 -1.01E7 -0.26 1.34870378E8 -1.65E7 -0.46 -0.5146 -0.9637 3187975 PK04_101307 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P10 compound treatment 1.49004594E8 -2.07E7 -0.54 1.5014654E8 -1210000.0 -0.03 -0.4079 -0.7501 3187974 PK04_101308 CCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P11 mock treatment 1.51459277E8 -1.83E7 -0.48 1.29205655E8 -2.22E7 -0.62 -0.7797 -0.9914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P12 mock treatment 1.55821167E8 -1.39E7 -0.36 1.33526951E8 -1.78E7 -0.5 -0.6129 -0.9875 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P13 compound treatment 1.66491249E8 -3240000.0 -0.08 1.33557037E8 -1.78E7 -0.5 -0.4148 -0.8152 3069986 PK04_101309 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P14 compound treatment 1.56699647E8 -1.3E7 -0.34 1.43527951E8 -7830000.0 -0.22 -0.3973 -0.9777 3069301 PK04_101310 CCCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P15 compound treatment 1.62428076E8 -7310000.0 -0.19 1.46546137E8 -4810000.0 -0.14 -0.2311 -0.9858 3187976 PK04_101311 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCCCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P16 compound treatment 1.67277584E8 -2460000.0 -0.06 1.56246464E8 4890000.0 0.14 0.0519 0.3414 3069301 PK04_101312 CCCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P17 compound treatment 1.74614114E8 4880000.0 0.13 1.54408909E8 3050000.0 0.09 0.1511 0.9815 3187977 PK04_101313 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P18 compound treatment 1.58929254E8 -1.08E7 -0.28 1.56238353E8 4880000.0 0.14 -0.1028 -0.3267 3069302 PK04_101314 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P19 compound treatment 1.59231008E8 -1.05E7 -0.27 1.62442598E8 1.11E7 0.31 0.0264 0.0635 3189130 PK04_101315 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P20 compound treatment 1.92139492E8 2.24E7 0.59 1.7759881E8 2.62E7 0.74 0.9376 0.9934 3069302 PK04_101316 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P21 compound treatment 2.01121561E8 3.14E7 0.82 1.88314562E8 3.7E7 1.04 1.3174 0.9931 3189131 PK04_101317 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5c(Cl)cccc5CO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P22 compound treatment 2.03786654E8 3.41E7 0.89 1.84556091E8 3.32E7 0.94 1.2918 0.9997 3069303 PK04_101318 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P23 compound treatment 1.83947876E8 1.42E7 0.37 1.72363163E8 2.1E7 0.59 0.6816 0.9749 3069685 PK04_101319 OCc1cccc(Cl)c1N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2101 P24 compound treatment 2.4807908E8 7.83E7 2.05 2.30122586E8 7.88E7 2.22 3.0196 0.9992 3069303 PK04_101320 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A01 compound treatment 1.65431109E8 1.09E7 0.29 1.54412269E8 -441000.0 -0.01 0.193 0.6757 3188092 PK04_102001 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A02 compound treatment 7.3073713E7 -8.15E7 -2.13 1.13967097E8 -4.09E7 -1.15 -2.3224 -0.9583 3188093 PK04_102002 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A03 compound treatment 9.6174342E7 -5.84E7 -1.53 9.5009964E7 -5.98E7 -1.69 -2.2726 -0.9988 3069304 PK04_102003 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccccc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A04 compound treatment 8.9171258E7 -6.54E7 -1.71 7.4929228E7 -7.99E7 -2.25 -2.8023 -0.9908 3188094 PK04_102004 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A05 compound treatment 1.83371566E8 2.88E7 0.76 1.89689981E8 3.48E7 0.98 1.2281 0.9916 3069305 PK04_102005 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A06 compound treatment 5.5883973E7 -9.86E7 -2.58 6.4462184E7 -9.04E7 -2.55 -3.627 -1.0 3188095 PK04_102006 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A07 compound treatment 5.8304211E7 -9.62E7 -2.52 7.1063428E7 -8.38E7 -2.36 -3.4507 -0.9995 3069306 PK04_102007 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A08 compound treatment 3.6908302E7 -1.18E8 -3.08 3.8333696E7 -1.17E8 -3.28 -4.4989 -0.9995 3188096 PK04_102008 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A09 compound treatment 1.361508E8 -1.84E7 -0.48 1.55233845E8 380000.0 0.01 -0.3326 -0.6912 3188097 PK04_102009 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A10 compound treatment 5.3871801E7 -1.01E8 -2.63 5.9069646E7 -9.58E7 -2.7 -3.7717 -0.9999 3069307 PK04_102010 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A11 compound treatment 1.41619235E8 -1.29E7 -0.34 1.41643271E8 -1.32E7 -0.37 -0.5022 -0.9988 3188098 PK04_102011 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A12 compound treatment 4.2420606E7 -1.12E8 -2.93 4.2875291E7 -1.12E8 -3.16 -4.3064 -0.9993 3069308 PK04_102012 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A13 mock treatment 1.98544417E8 4.4E7 1.15 1.93456629E8 3.86E7 1.09 1.584 0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A14 mock treatment 1.77111388E8 2.26E7 0.59 1.75047175E8 2.02E7 0.57 0.8204 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A15 compound treatment 3.0037926E7 -1.24E8 -3.26 2.9681582E7 -1.25E8 -3.53 -4.7985 -0.9992 3188099 PK04_102013 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A16 compound treatment 7.1980021E7 -8.25E7 -2.16 7.4147527E7 -8.07E7 -2.27 -3.1361 -0.9997 3188100 PK04_102014 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A17 compound treatment 6.7716693E7 -8.68E7 -2.27 6.8280547E7 -8.66E7 -2.44 -3.3319 -0.9994 3069309 PK04_102015 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@]5(O[C@H](CCO)[C@H]([C@@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A18 compound treatment 5.9139489E7 -9.54E7 -2.5 6.81047E7 -8.67E7 -2.44 -3.4942 -0.9999 3188101 PK04_102016 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A19 compound treatment 2.8655773E7 -1.26E8 -3.29 2.8858022E7 -1.26E8 -3.55 -4.8405 -0.9993 3069310 PK04_102017 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A20 compound treatment 1.11469918E8 -4.31E7 -1.13 1.25840983E8 -2.9E7 -0.82 -1.3751 -0.9876 3188102 PK04_102018 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@@]5(O[C@@H](CCO)[C@@H]([C@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A21 compound treatment 1.64008632E8 9480000.0 0.25 1.68332894E8 1.35E7 0.38 0.4441 0.9787 3188103 PK04_102019 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A22 compound treatment 8.3620806E7 -7.09E7 -1.86 8.0176742E7 -7.47E7 -2.1 -2.8005 -0.998 3069311 PK04_102020 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A23 compound treatment 1.60194829E8 5670000.0 0.15 1.67393263E8 1.25E7 0.35 0.3548 0.9257 3188104 PK04_102021 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 A24 compound treatment 1.9550964E8 4.1E7 1.07 2.06370727E8 5.15E7 1.45 1.7851 0.9889 3188105 PK04_102022 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B01 compound treatment 1.49455987E8 -5070000.0 -0.13 1.55812868E8 959000.0 0.03 -0.0747 -0.5518 3069350 PK04_102023 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B02 compound treatment 7.3443545E7 -8.11E7 -2.12 9.7686068E7 -5.72E7 -1.61 -2.64 -0.9907 3188106 PK04_102024 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B03 compound treatment 1.45619687E8 -8910000.0 -0.23 1.54600705E8 -253000.0 -0.01 -0.1699 -0.7284 3069351 PK04_102025 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCCCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B04 compound treatment 8.6124969E7 -6.84E7 -1.79 9.6313445E7 -5.85E7 -1.65 -2.4326 -0.9992 3188107 PK04_102026 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B05 compound treatment 8.5363406E7 -6.92E7 -1.81 1.08841204E8 -4.6E7 -1.3 -2.1971 -0.9866 3188221 PK04_102027 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B06 compound treatment 7.2858027E7 -8.17E7 -2.14 5.6510711E7 -9.83E7 -2.77 -3.4713 -0.9918 3069352 PK04_102028 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B07 compound treatment 5.8542215E7 -9.6E7 -2.51 6.4231725E7 -9.06E7 -2.55 -3.5824 -1.0 3188222 PK04_102029 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B08 compound treatment 6.32125E7 -9.13E7 -2.39 6.4381934E7 -9.05E7 -2.55 -3.493 -0.9995 3069353 PK04_102030 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B09 compound treatment 5.7561924E7 -9.7E7 -2.54 6.4464268E7 -9.04E7 -2.55 -3.5959 -1.0 3188223 PK04_102031 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B10 compound treatment 8.8623274E7 -6.59E7 -1.73 8.593371E7 -6.89E7 -1.94 -2.5932 -0.9983 3188224 PK04_102032 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B11 compound treatment 1.17680819E8 -3.68E7 -0.96 1.19145846E8 -3.57E7 -1.01 -1.3935 -0.9998 3069354 PK04_102033 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B12 compound treatment 7.4400225E7 -8.01E7 -2.1 7.0492719E7 -8.44E7 -2.38 -3.1641 -0.9981 3188225 PK04_102034 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B13 mock treatment 1.58709151E8 4180000.0 0.11 1.61686396E8 6830000.0 0.19 0.2136 0.9642 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B14 mock treatment 1.57156938E8 2630000.0 0.07 1.53475855E8 -1380000.0 -0.04 0.0212 0.2686 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B15 compound treatment 5.9805477E7 -9.47E7 -2.48 6.0731517E7 -9.41E7 -2.65 -3.6288 -0.9994 3188226 PK04_102035 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B16 compound treatment 1.34285919E8 -2.02E7 -0.53 1.20797866E8 -3.41E7 -0.96 -1.0533 -0.9608 3069355 PK04_102036 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B17 compound treatment 8.9985286E7 -6.45E7 -1.69 9.2022213E7 -6.28E7 -1.77 -2.4467 -0.9997 3188227 PK04_102037 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B18 compound treatment 6.9997371E7 -8.45E7 -2.21 6.4529117E7 -9.03E7 -2.55 -3.3645 -0.9976 3069356 PK04_102038 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B19 compound treatment 1.47728189E8 -6800000.0 -0.18 1.50167654E8 -4690000.0 -0.13 -0.2192 -0.9892 3188228 PK04_102039 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B20 compound treatment 1.47054827E8 -7470000.0 -0.2 1.34623536E8 -2.02E7 -0.57 -0.5414 -0.8983 3188229 PK04_102040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B21 compound treatment 1.49733293E8 -4790000.0 -0.13 1.54122614E8 -731000.0 -0.02 -0.1033 -0.8123 3069357 PK04_102041 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B22 compound treatment 9.1822768E7 -6.27E7 -1.64 9.3453181E7 -6.14E7 -1.73 -2.3841 -0.9997 3188230 PK04_102042 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(I)c6)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B23 compound treatment 9.8022002E7 -5.65E7 -1.48 1.02715133E8 -5.21E7 -1.47 -2.0848 -1.0 3069358 PK04_102043 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 B24 compound treatment 1.9141396E8 3.69E7 0.97 1.7559495E8 2.07E7 0.58 1.0961 0.9711 3188231 PK04_102044 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C01 compound treatment 1.99733803E8 4.52E7 1.18 2.00317532E8 4.55E7 1.28 1.7427 0.9992 3188232 PK04_102045 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C02 compound treatment 8.1532288E7 -7.3E7 -1.91 8.2013982E7 -7.28E7 -2.05 -2.8026 -0.9994 3069359 PK04_102046 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C03 compound treatment 1.4932121E8 -5210000.0 -0.14 1.5049479E8 -4360000.0 -0.12 -0.1832 -0.9987 3188233 PK04_102047 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C04 compound treatment 1.26538724E8 -2.8E7 -0.73 1.31977379E8 -2.29E7 -0.64 -0.9739 -0.998 3188234 PK04_102048 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C05 compound treatment 1.54970031E8 443000.0 0.01 1.5703122E8 2180000.0 0.06 0.0516 0.8261 3069360 PK04_102049 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C06 compound treatment 2.8800934E7 -1.26E8 -3.29 2.7934019E7 -1.27E8 -3.58 -4.8562 -0.9991 3188235 PK04_102050 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C07 compound treatment 1.13013789E8 -4.15E7 -1.09 1.16627521E8 -3.82E7 -1.08 -1.5301 -1.0 3069393 PK04_102051 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C08 compound treatment 7.3402908E7 -8.11E7 -2.12 5.3223881E7 -1.02E8 -2.86 -3.5267 -0.9892 3188236 PK04_102052 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C09 compound treatment 2.8402951E7 -1.26E8 -3.3 2.8460404E7 -1.26E8 -3.56 -4.8531 -0.9993 3069394 PK04_102053 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C10 compound treatment 4.2539114E7 -1.12E8 -2.93 3.4654651E7 -1.2E8 -3.39 -4.468 -0.9974 3188352 PK04_102054 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C11 mock treatment 1.63925453E8 9400000.0 0.25 1.6433016E8 9480000.0 0.27 0.3628 0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C12 mock treatment 1.53844641E8 -682000.0 -0.02 1.46969429E8 -7880000.0 -0.22 -0.1697 -0.7615 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C13 compound treatment 1.16476437E8 -3.81E7 -1.0 1.05931631E8 -4.89E7 -1.38 -1.6792 -0.9873 3188353 PK04_102055 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C14 compound treatment 2.9214513E7 -1.25E8 -3.28 2.8809943E7 -1.26E8 -3.55 -4.8311 -0.9992 3069395 PK04_102056 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C15 mock treatment 1.60424027E8 5900000.0 0.15 1.61958111E8 7100000.0 0.2 0.2507 0.9917 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C16 mock treatment 1.599731E8 5450000.0 0.14 1.55426481E8 573000.0 0.02 0.1122 0.7822 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C17 compound treatment 4.4755218E7 -1.1E8 -2.87 4.2352433E7 -1.13E8 -3.17 -4.2736 -0.9988 3188354 PK04_102057 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C18 compound treatment 1.49692075E8 -4830000.0 -0.13 1.23332682E8 -3.15E7 -0.89 -0.7176 -0.7998 3069396 PK04_102058 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C19 compound treatment 4.2372838E7 -1.12E8 -2.94 4.5714249E7 -1.09E8 -3.08 -4.2507 -0.9997 3188355 PK04_102059 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C20 compound treatment 5.4639432E7 -9.99E7 -2.61 5.1423623E7 -1.03E8 -2.91 -3.9099 -0.9985 3188356 PK04_102060 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C21 compound treatment 1.10106376E8 -4.44E7 -1.16 1.16223801E8 -3.86E7 -1.09 -1.592 -0.9995 3069397 PK04_102061 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C22 compound treatment 7.6019621E7 -7.85E7 -2.06 7.8370248E7 -7.65E7 -2.16 -2.9772 -0.9997 3188357 PK04_102062 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C23 compound treatment 4.9990934E7 -1.05E8 -2.74 4.6243622E7 -1.09E8 -3.06 -4.0992 -0.9984 3188358 PK04_102063 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 C24 compound treatment 8.517524E7 -6.94E7 -1.82 9.84869E7 -5.64E7 -1.59 -2.4069 -0.9978 3069398 PK04_102064 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D01 compound treatment 5.5569472E7 -9.9E7 -2.59 8.806144E7 -6.68E7 -1.88 -3.1626 -0.9877 3188359 PK04_102065 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D02 compound treatment 8.5622604E7 -6.89E7 -1.8 9.8382979E7 -5.65E7 -1.59 -2.4007 -0.998 3069399 PK04_102066 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(I)cc6)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D03 compound treatment 8.9482437E7 -6.5E7 -1.7 6.7726846E7 -8.71E7 -2.46 -2.9401 -0.984 3188360 PK04_102067 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D04 compound treatment 1.3954635E8 -1.5E7 -0.39 1.30571998E8 -2.43E7 -0.68 -0.7611 -0.9651 3188361 PK04_102068 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D05 compound treatment 6.3583709E7 -9.09E7 -2.38 6.5224742E7 -8.96E7 -2.53 -3.4693 -0.9996 3069400 PK04_102069 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D06 compound treatment 1.23892683E8 -3.06E7 -0.8 1.2900818E8 -2.58E7 -0.73 -1.082 -0.9988 3188362 PK04_102070 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D07 compound treatment 1.13106911E8 -4.14E7 -1.08 1.21902619E8 -3.3E7 -0.93 -1.4233 -0.997 3188363 PK04_102071 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D08 compound treatment 1.48070559E8 -6460000.0 -0.17 1.63344954E8 8490000.0 0.24 0.0497 0.1696 3069401 PK04_102072 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D09 compound treatment 6.3003738E7 -9.15E7 -2.4 6.9799801E7 -8.51E7 -2.4 -3.3889 -1.0 3188364 PK04_102073 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D10 compound treatment 1.40004584E8 -1.45E7 -0.38 1.46162533E8 -8690000.0 -0.24 -0.442 -0.9774 3069402 PK04_102074 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D11 mock treatment 1.53259313E8 -1270000.0 -0.03 1.56173459E8 1320000.0 0.04 0.0028 0.0569 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D12 mock treatment 1.59030653E8 4500000.0 0.12 1.57172738E8 2320000.0 0.07 0.1296 0.9613 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D13 compound treatment 1.4347806E8 -1.1E7 -0.29 1.42911083E8 -1.19E7 -0.34 -0.4425 -0.9972 3069403 PK04_102075 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D14 compound treatment 1.01134912E8 -5.34E7 -1.4 6.2836024E7 -9.2E7 -2.59 -2.8219 -0.9579 3188365 PK04_102076 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D15 mock treatment 1.58065316E8 3540000.0 0.09 1.51829333E8 -3020000.0 -0.09 0.0052 0.0416 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D16 mock treatment 1.65465166E8 1.09E7 0.29 1.65548049E8 1.07E7 0.3 0.4156 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D17 compound treatment 1.28659955E8 -2.59E7 -0.68 1.30951482E8 -2.39E7 -0.67 -0.9551 -1.0 3188366 PK04_102077 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D18 compound treatment 1.6702576E8 1.25E7 0.33 1.66744633E8 1.19E7 0.34 0.4683 0.9999 3069404 PK04_102078 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D19 compound treatment 1.29527784E8 -2.5E7 -0.65 1.45078157E8 -9780000.0 -0.28 -0.6575 -0.9261 3188367 PK04_102079 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D20 compound treatment 5.922198E7 -9.53E7 -2.49 1.07173972E8 -4.77E7 -1.34 -2.7142 -0.9579 3069405 PK04_102080 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D21 compound treatment 1.07933945E8 -4.66E7 -1.22 1.04125909E8 -5.07E7 -1.43 -1.8733 -0.9969 3188368 PK04_102081 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D22 compound treatment 1.68965366E8 1.44E7 0.38 1.61945037E8 7090000.0 0.2 0.4086 0.9556 3069440 PK04_102082 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D23 compound treatment 1.65259409E8 1.07E7 0.28 1.01740367E8 -5.31E7 -1.5 -0.8597 -0.5645 3188485 PK04_102083 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 D24 compound treatment 2.05940563E8 5.14E7 1.35 2.09039359E8 5.42E7 1.53 2.0314 0.998 3069441 PK04_102084 O[C@H](CC=C)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E01 mock treatment 1.83272251E8 2.87E7 0.75 1.98509808E8 4.37E7 1.23 1.402 0.9722 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E02 mock treatment 1.67285683E8 1.28E7 0.33 1.73967331E8 1.91E7 0.54 0.617 0.9736 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E03 compound treatment 1.51870826E8 -2660000.0 -0.07 1.4406663E8 -1.08E7 -0.3 -0.2641 -0.847 3069442 PK04_102085 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E04 compound treatment 5.7568414E7 -9.7E7 -2.54 6.5333947E7 -8.95E7 -2.52 -3.5785 -1.0 3188486 PK04_102086 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E05 compound treatment 4.9523622E7 -1.05E8 -2.75 5.3330155E7 -1.02E8 -2.86 -3.9666 -0.9998 3188487 PK04_102087 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E06 compound treatment 7.4930662E7 -7.96E7 -2.08 7.7091553E7 -7.78E7 -2.19 -3.0228 -0.9997 3069443 PK04_102088 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E07 compound treatment 3.5562202E7 -1.19E8 -3.11 3.427322E7 -1.21E8 -3.4 -4.6048 -0.9991 3188488 PK04_102089 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E08 compound treatment 2.8891036E7 -1.26E8 -3.29 2.821096E7 -1.27E8 -3.57 -4.849 -0.9992 3188489 PK04_102090 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E09 mock treatment 1.52544549E8 -1980000.0 -0.05 1.56419913E8 1570000.0 0.04 -0.0055 -0.0804 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E10 mock treatment 1.56134075E8 1610000.0 0.04 1.55681664E8 828000.0 0.02 0.0462 0.9614 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E11 compound treatment 6.5736132E7 -8.88E7 -2.32 6.9064964E7 -8.58E7 -2.42 -3.353 -0.9998 3069444 PK04_102091 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E12 compound treatment 5.0017925E7 -1.05E8 -2.74 4.7070865E7 -1.08E8 -3.04 -4.0822 -0.9986 3188490 PK04_102092 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E13 compound treatment 8.3341126E7 -7.12E7 -1.86 8.6375368E7 -6.85E7 -1.93 -2.6822 -0.9998 3069445 PK04_102093 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E14 compound treatment 4.1150584E7 -1.13E8 -2.97 4.1996298E7 -1.13E8 -3.18 -4.3474 -0.9994 3188491 PK04_102094 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E15 compound treatment 3.9393177E7 -1.15E8 -3.01 3.8267212E7 -1.17E8 -3.29 -4.4543 -0.9991 3188492 PK04_102095 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E16 compound treatment 8.0332058E7 -7.42E7 -1.94 1.03989643E8 -5.09E7 -1.43 -2.3869 -0.9888 3069446 PK04_102096 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E17 mock treatment 1.49483206E8 -5040000.0 -0.13 1.60586457E8 5730000.0 0.16 0.0209 0.1001 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E18 mock treatment 1.8686697E8 3.23E7 0.85 1.65334905E8 1.05E7 0.3 0.8075 0.9006 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E19 compound treatment 9.5024334E7 -5.95E7 -1.56 7.1590573E7 -8.33E7 -2.35 -2.7605 -0.9802 3188493 PK04_102097 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E20 compound treatment 1.55305506E8 779000.0 0.02 1.37929897E8 -1.69E7 -0.48 -0.3228 -0.6763 3188494 PK04_102098 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E21 compound treatment 6.3923254E7 -9.06E7 -2.37 6.0162693E7 -9.47E7 -2.67 -3.5639 -0.9983 3069448 PK04_102099 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E22 compound treatment 7.6439242E7 -7.81E7 -2.04 6.9605282E7 -8.52E7 -2.4 -3.1441 -0.9968 3188495 PK04_102100 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E23 compound treatment 8.7481779E7 -6.7E7 -1.76 7.105067E7 -8.38E7 -2.36 -2.9109 -0.9893 3069450 PK04_102101 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 E24 compound treatment 1.73806808E8 1.93E7 0.5 1.79121748E8 2.43E7 0.68 0.8404 0.9888 3188496 PK04_102102 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F01 mock treatment 1.74418108E8 1.99E7 0.52 1.95154964E8 4.03E7 1.14 1.1713 0.9375 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F02 mock treatment 1.78236791E8 2.37E7 0.62 1.76398845E8 2.15E7 0.61 0.8682 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F03 compound treatment 1.09526998E8 -4.5E7 -1.18 1.14273957E8 -4.06E7 -1.14 -1.6416 -0.9999 3188497 PK04_102103 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F04 compound treatment 1.06454994E8 -4.81E7 -1.26 1.07738669E8 -4.71E7 -1.33 -1.8286 -0.9996 3069264 PK04_102104 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F05 compound treatment 1.33802295E8 -2.07E7 -0.54 1.33810233E8 -2.1E7 -0.59 -0.8029 -0.999 3069265 PK04_102105 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F06 compound treatment 4.7259356E7 -1.07E8 -2.81 4.5538873E7 -1.09E8 -3.08 -4.1638 -0.9989 3188498 PK04_102106 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F07 compound treatment 5.6269006E7 -9.83E7 -2.57 5.6420936E7 -9.84E7 -2.77 -3.7802 -0.9993 3188499 PK04_102107 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F08 compound treatment 1.42780068E8 -1.17E7 -0.31 1.48129401E8 -6720000.0 -0.19 -0.3514 -0.9729 3069441 PK04_102108 O[C@H](CC=C)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F09 mock treatment 1.55489479E8 963000.0 0.03 1.58270617E8 3420000.0 0.1 0.0859 0.8631 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F10 mock treatment 1.46937183E8 -7590000.0 -0.2 1.47301479E8 -7550000.0 -0.21 -0.291 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F11 compound treatment 5.7593691E7 -9.69E7 -2.54 5.8252417E7 -9.66E7 -2.72 -3.7191 -0.9994 3188500 PK04_102109 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F12 compound treatment 1.49549985E8 -4980000.0 -0.13 1.4986703E8 -4990000.0 -0.14 -0.1915 -0.9993 3069270 PK04_102110 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F13 compound treatment 6.1092328E7 -9.34E7 -2.45 6.6249073E7 -8.86E7 -2.5 -3.495 -0.9999 3188501 PK04_102111 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F14 compound treatment 1.43979542E8 -1.05E7 -0.28 1.46659424E8 -8190000.0 -0.23 -0.3585 -0.9961 3188502 PK04_102112 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F15 compound treatment 1.28319323E8 -2.62E7 -0.69 1.24192522E8 -3.07E7 -0.86 -1.0961 -0.9935 3188623 PK04_102113 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F16 compound treatment 1.3884984E8 -1.57E7 -0.41 1.42493648E8 -1.24E7 -0.35 -0.5365 -0.9967 3069312 PK04_102114 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F17 mock treatment 1.62865018E8 8340000.0 0.22 1.56838815E8 1990000.0 0.06 0.1939 0.8605 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F18 mock treatment 1.64920042E8 1.04E7 0.27 1.59773672E8 4920000.0 0.14 0.2904 0.9511 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F19 compound treatment 8.312627E7 -7.14E7 -1.87 8.165766E7 -7.32E7 -2.06 -2.7802 -0.9988 3188624 PK04_102115 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F20 compound treatment 1.68311593E8 1.38E7 0.36 1.6199713E8 7140000.0 0.2 0.3975 0.962 3069314 PK04_102116 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F21 compound treatment 1.27535248E8 -2.7E7 -0.71 1.16107568E8 -3.87E7 -1.09 -1.2717 -0.9778 3069316 PK04_102117 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F22 compound treatment 8.4874733E7 -6.97E7 -1.82 9.2448364E7 -6.24E7 -1.76 -2.5328 -0.9998 3188625 PK04_102118 O[C@@H](CC=C)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F23 compound treatment 1.03845836E8 -5.07E7 -1.33 7.6539488E7 -7.83E7 -2.21 -2.4986 -0.9703 3188626 PK04_102119 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 F24 compound treatment 2.18048412E8 6.35E7 1.66 2.06207534E8 5.14E7 1.45 2.1991 0.9976 3069318 PK04_102120 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G01 compound treatment 1.38583439E8 -1.59E7 -0.42 1.54615249E8 -238000.0 -0.01 -0.2999 -0.7184 3069320 PK04_102121 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO)nn2)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G02 compound treatment 1.30528652E8 -2.4E7 -0.63 1.48494859E8 -6360000.0 -0.18 -0.5709 -0.8739 3188627 PK04_102122 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G03 mock treatment 1.61822683E8 7300000.0 0.19 1.6816338E8 1.33E7 0.38 0.4003 0.951 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G04 mock treatment 1.64303188E8 9780000.0 0.26 1.53575259E8 -1280000.0 -0.04 0.1555 0.6016 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G05 compound treatment 1.01331645E8 -5.32E7 -1.39 1.03798791E8 -5.11E7 -1.44 -2.002 -0.9999 3069321 PK04_102123 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G06 compound treatment 2.7959451E7 -1.27E8 -3.31 2.8454639E7 -1.26E8 -3.56 -4.8614 -0.9993 3188628 PK04_102124 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G07 compound treatment 8.1974765E7 -7.26E7 -1.9 8.0633776E7 -7.42E7 -2.09 -2.8219 -0.9988 3069362 PK04_102125 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4ccccc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G08 compound treatment 5.2757674E7 -1.02E8 -2.66 5.5415296E7 -9.94E7 -2.8 -3.8652 -0.9997 3188629 PK04_102126 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G09 compound treatment 2.8971024E7 -1.26E8 -3.29 2.8414084E7 -1.26E8 -3.56 -4.8435 -0.9992 3188630 PK04_102127 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G10 compound treatment 7.5680052E7 -7.88E7 -2.06 8.1248313E7 -7.36E7 -2.07 -2.9261 -1.0 3188631 PK04_102128 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G11 compound treatment 2.8520343E7 -1.26E8 -3.3 2.8499661E7 -1.26E8 -3.56 -4.8502 -0.9993 3069365 PK04_102129 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G12 compound treatment 1.23043773E8 -3.15E7 -0.82 1.31195686E8 -2.37E7 -0.67 -1.0542 -0.9945 3188632 PK04_102130 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G13 compound treatment 5.3585305E7 -1.01E8 -2.64 4.9417048E7 -1.05E8 -2.97 -3.9694 -0.9983 3069368 PK04_102131 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccccc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G14 compound treatment 3.2660984E7 -1.22E8 -3.19 2.9690104E7 -1.25E8 -3.53 -4.7498 -0.9987 3069370 PK04_102132 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G15 compound treatment 3.7860183E7 -1.17E8 -3.05 3.1678448E7 -1.23E8 -3.47 -4.6139 -0.998 3188633 PK04_102133 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G16 compound treatment 3.898811E7 -1.16E8 -3.02 3.4928048E7 -1.2E8 -3.38 -4.5283 -0.9985 3188634 PK04_102134 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G17 compound treatment 2.8657281E7 -1.26E8 -3.29 2.8703363E7 -1.26E8 -3.55 -4.8436 -0.9993 3188635 PK04_102135 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G18 compound treatment 1.20976089E8 -3.36E7 -0.88 1.20104317E8 -3.47E7 -0.98 -1.3135 -0.9985 3069408 PK04_102136 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G19 mock treatment 1.61063861E8 6540000.0 0.17 1.62491512E8 7640000.0 0.22 0.2732 0.9935 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G20 mock treatment 1.6547059E8 1.09E7 0.29 1.65877265E8 1.1E7 0.31 0.4222 0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G21 compound treatment 2.958617E7 -1.25E8 -3.27 2.9008839E7 -1.26E8 -3.55 -4.8203 -0.9992 3188636 PK04_102137 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G22 compound treatment 9.0410573E7 -6.41E7 -1.68 6.4828752E7 -9.0E7 -2.54 -2.9807 -0.9799 3188637 PK04_102138 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G23 compound treatment 1.45978054E8 -8550000.0 -0.22 1.20802781E8 -3.41E7 -0.96 -0.8368 -0.8492 3069412 PK04_102139 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 G24 compound treatment 8.2880104E7 -7.16E7 -1.88 1.23970105E8 -3.09E7 -0.87 -1.9416 -0.9391 3188638 PK04_102140 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H01 compound treatment 5.7567925E7 -9.7E7 -2.54 7.8467663E7 -7.64E7 -2.15 -3.3168 -0.9966 3188639 PK04_102141 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H02 compound treatment 1.56492309E8 1970000.0 0.05 1.62351405E8 7500000.0 0.21 0.1858 0.8543 3069414 PK04_102142 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H03 mock treatment 1.63140609E8 8610000.0 0.23 1.7119695E8 1.63E7 0.46 0.4851 0.946 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H04 mock treatment 1.43477607E8 -1.1E7 -0.29 1.63646754E8 8790000.0 0.25 -0.0293 -0.0769 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H05 compound treatment 5.5714191E7 -9.88E7 -2.59 5.4329936E7 -1.01E8 -2.83 -3.8321 -0.999 3188755 PK04_102143 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H06 compound treatment 1.23278772E8 -3.12E7 -0.82 1.28879471E8 -2.6E7 -0.73 -1.096 -0.9985 3188362 PK04_102144 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H07 compound treatment 6.3591468E7 -9.09E7 -2.38 7.4591753E7 -8.03E7 -2.26 -3.2825 -0.9997 3188756 PK04_102145 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H08 compound treatment 6.4142763E7 -9.04E7 -2.37 7.6481333E7 -7.84E7 -2.21 -3.2347 -0.9994 3069452 PK04_102146 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H09 compound treatment 5.4335893E7 -1.0E8 -2.62 4.6548968E7 -1.08E8 -3.05 -4.0127 -0.9971 3188757 PK04_102147 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H10 compound treatment 3.9475543E7 -1.15E8 -3.01 3.8097541E7 -1.17E8 -3.29 -4.4561 -0.999 3069454 PK04_102148 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H11 compound treatment 4.4347504E7 -1.1E8 -2.88 4.4283199E7 -1.11E8 -3.12 -4.2427 -0.9993 3188758 PK04_102149 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H12 compound treatment 9.0349167E7 -6.42E7 -1.68 8.7081036E7 -6.78E7 -1.91 -2.5384 -0.998 3069456 PK04_102150 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H13 compound treatment 7.0459873E7 -8.41E7 -2.2 8.1577163E7 -7.33E7 -2.06 -3.0162 -0.9995 3188759 PK04_102151 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H14 compound treatment 2.8393466E7 -1.26E8 -3.3 2.8585838E7 -1.26E8 -3.56 -4.8508 -0.9993 3069458 PK04_102152 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H15 compound treatment 1.03189165E8 -5.13E7 -1.34 1.06487581E8 -4.84E7 -1.36 -1.914 -1.0 3188760 PK04_102153 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H16 compound treatment 1.39645288E8 -1.49E7 -0.39 1.37530348E8 -1.73E7 -0.49 -0.6206 -0.9937 3069460 PK04_102154 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H17 compound treatment 5.8576466E7 -9.6E7 -2.51 5.6704584E7 -9.81E7 -2.77 -3.7318 -0.9988 3188761 PK04_102155 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H18 compound treatment 3.1223449E7 -1.23E8 -3.23 2.9332465E7 -1.26E8 -3.54 -4.7835 -0.999 3069461 PK04_102156 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H19 mock treatment 1.57739111E8 3210000.0 0.08 1.59469453E8 4620000.0 0.13 0.1514 0.9777 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H20 mock treatment 1.60812049E8 6290000.0 0.16 1.60395107E8 5540000.0 0.16 0.2268 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H21 compound treatment 1.2361284E8 -3.09E7 -0.81 9.7081301E7 -5.78E7 -1.63 -1.7234 -0.9479 3188762 PK04_102157 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H22 compound treatment 1.02164653E8 -5.24E7 -1.37 9.8801493E7 -5.61E7 -1.58 -2.0861 -0.9975 3069504 PK04_102158 O[C@H](CC=C)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H23 compound treatment 6.9011754E7 -8.55E7 -2.24 6.4053826E7 -9.08E7 -2.56 -3.3922 -0.9978 3188763 PK04_102159 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 H24 compound treatment 2.05765868E8 5.12E7 1.34 1.94902579E8 4.0E7 1.13 1.7465 0.9963 3069401 PK04_102160 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I01 compound treatment 7.9826376E7 -7.47E7 -1.96 1.06798579E8 -4.81E7 -1.35 -2.3403 -0.9839 3069507 PK04_102161 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I02 compound treatment 5.8167641E7 -9.64E7 -2.52 6.7567354E7 -8.73E7 -2.46 -3.5229 -0.9999 3188764 PK04_102162 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I03 compound treatment 1.35584944E8 -1.89E7 -0.5 1.40157026E8 -1.47E7 -0.41 -0.6435 -0.996 3188765 PK04_102163 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I04 compound treatment 2.9420036E7 -1.25E8 -3.27 3.1404665E7 -1.23E8 -3.48 -4.7756 -0.9995 3069594 PK04_102164 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I05 mock treatment 1.52883696E8 -1640000.0 -0.04 1.5761279E8 2760000.0 0.08 0.0246 0.2765 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I06 mock treatment 1.51130025E8 -3400000.0 -0.09 1.57066553E8 2210000.0 0.06 -0.0188 -0.1729 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I07 compound treatment 1.37294516E8 -1.72E7 -0.45 1.43525382E8 -1.13E7 -0.32 -0.5447 -0.9857 3188766 PK04_102165 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I08 compound treatment 1.03113381E8 -5.14E7 -1.35 1.01339571E8 -5.35E7 -1.51 -2.018 -0.9984 3188767 PK04_102166 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I09 compound treatment 1.44153903E8 -1.04E7 -0.27 1.53190016E8 -1660000.0 -0.05 -0.2252 -0.8171 3069598 PK04_102167 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I10 compound treatment 3.141634E7 -1.23E8 -3.22 3.6682126E7 -1.18E8 -3.33 -4.6335 -0.9999 3188768 PK04_102168 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I11 compound treatment 2.8316844E7 -1.26E8 -3.3 2.9123232E7 -1.26E8 -3.54 -4.8415 -0.9994 3188769 PK04_102169 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I12 compound treatment 4.7404837E7 -1.07E8 -2.8 5.3239864E7 -1.02E8 -2.86 -4.0076 -0.9999 3069636 PK04_102170 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I13 compound treatment 3.2577786E7 -1.22E8 -3.19 3.0049198E7 -1.25E8 -3.52 -4.7442 -0.9988 3188770 PK04_102171 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I14 compound treatment 3.7573042E7 -1.17E8 -3.06 3.5704059E7 -1.19E8 -3.36 -4.539 -0.9989 3188771 PK04_102172 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I15 compound treatment 1.2634897E8 -2.82E7 -0.74 1.25022051E8 -2.98E7 -0.84 -1.116 -0.9979 3069640 PK04_102173 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I16 compound treatment 5.1689081E7 -1.03E8 -2.69 4.3032342E7 -1.12E8 -3.15 -4.1317 -0.9969 3188888 PK04_102174 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I17 compound treatment 1.03348857E8 -5.12E7 -1.34 8.8921732E7 -6.59E7 -1.86 -2.2611 -0.9871 3069645 PK04_102175 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I18 compound treatment 1.19720115E8 -3.48E7 -0.91 1.01127862E8 -5.37E7 -1.51 -1.7148 -0.9705 3188889 PK04_102176 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I19 compound treatment 4.7887857E7 -1.07E8 -2.79 4.2334202E7 -1.13E8 -3.17 -4.216 -0.998 3069647 PK04_102177 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I20 compound treatment 4.1484057E7 -1.13E8 -2.96 3.7886394E7 -1.17E8 -3.3 -4.4232 -0.9986 3188890 PK04_102178 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I21 mock treatment 1.69467925E8 1.49E7 0.39 1.64624063E8 9770000.0 0.28 0.4712 0.9852 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I22 mock treatment 1.72636381E8 1.81E7 0.47 1.63964044E8 9110000.0 0.26 0.5167 0.9585 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I23 compound treatment 4.0755957E7 -1.14E8 -2.98 3.333166E7 -1.22E8 -3.42 -4.5274 -0.9976 3188891 PK04_102179 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 I24 compound treatment 5.5678009E7 -9.88E7 -2.59 6.1437607E7 -9.34E7 -2.63 -3.6911 -1.0 3069706 PK04_102180 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J01 compound treatment 5.0995316E7 -1.04E8 -2.71 7.082763E7 -8.4E7 -2.37 -3.5907 -0.9977 3188892 PK04_102181 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J02 compound treatment 1.51500451E8 -3030000.0 -0.08 1.55566264E8 713000.0 0.02 -0.0418 -0.5116 3069707 PK04_102182 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J03 compound treatment 4.5400924E7 -1.09E8 -2.86 4.7278679E7 -1.08E8 -3.03 -4.1635 -0.9996 3188893 PK04_102183 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J04 compound treatment 1.38854462E8 -1.57E7 -0.41 1.52141518E8 -2710000.0 -0.08 -0.3441 -0.8246 3069711 PK04_102184 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J05 mock treatment 1.5197958E8 -2550000.0 -0.07 1.52642219E8 -2210000.0 -0.06 -0.0912 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J06 mock treatment 1.41682155E8 -1.28E7 -0.34 1.49059662E8 -5790000.0 -0.16 -0.3532 -0.945 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J07 compound treatment 9.5292593E7 -5.92E7 -1.55 9.1226893E7 -6.36E7 -1.79 -2.3643 -0.9974 3188894 PK04_102185 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J08 compound treatment 2.9050974E7 -1.25E8 -3.28 2.8886876E7 -1.26E8 -3.55 -4.8326 -0.9992 3069714 PK04_102186 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J09 compound treatment 6.8450531E7 -8.61E7 -2.25 7.6795897E7 -7.81E7 -2.2 -3.1487 -0.9999 3188895 PK04_102187 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J10 compound treatment 1.32146221E8 -2.24E7 -0.59 1.42833995E8 -1.2E7 -0.34 -0.6538 -0.9661 3069716 PK04_102188 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J11 compound treatment 5.1159143E7 -1.03E8 -2.71 5.7317759E7 -9.75E7 -2.75 -3.8569 -1.0 3188896 PK04_102189 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J12 compound treatment 3.1260259E7 -1.23E8 -3.23 3.3901113E7 -1.21E8 -3.41 -4.6918 -0.9996 3069744 PK04_102190 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J13 compound treatment 6.2577745E7 -9.19E7 -2.41 6.3789022E7 -9.11E7 -2.57 -3.5166 -0.9995 3188897 PK04_102191 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J14 compound treatment 1.39648732E8 -1.49E7 -0.39 1.35759283E8 -1.91E7 -0.54 -0.6559 -0.9874 3069746 PK04_102192 OCCOc1ccc(cc1)[C@@H](O)CC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J15 compound treatment 5.4368995E7 -1.0E8 -2.62 4.5577147E7 -1.09E8 -3.08 -4.0314 -0.9968 3069749 PK04_102193 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J16 compound treatment 1.23235102E8 -3.13E7 -0.82 1.17969953E8 -3.69E7 -1.04 -1.3142 -0.993 3188898 PK04_102194 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J17 compound treatment 1.05272759E8 -4.93E7 -1.29 7.7586332E7 -7.73E7 -2.18 -2.4514 -0.9687 3188899 PK04_102195 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J18 compound treatment 9.454293E7 -6.0E7 -1.57 9.099767E7 -6.39E7 -1.8 -2.3827 -0.9977 3069504 PK04_102196 O[C@H](CC=C)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J19 compound treatment 1.05389842E8 -4.91E7 -1.29 8.0745023E7 -7.41E7 -2.09 -2.3862 -0.9729 3188900 PK04_102197 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J20 compound treatment 1.14441597E8 -4.01E7 -1.05 1.16359587E8 -3.85E7 -1.08 -1.509 -0.9999 3069264 PK04_102198 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J21 mock treatment 1.68941211E8 1.44E7 0.38 1.59130381E8 4280000.0 0.12 0.352 0.8887 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J22 mock treatment 1.74573478E8 2.0E7 0.52 1.70212754E8 1.54E7 0.43 0.6771 0.9954 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J23 compound treatment 1.3863005E8 -1.59E7 -0.42 1.31374736E8 -2.35E7 -0.66 -0.7621 -0.975 3069786 PK04_102199 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 J24 compound treatment 1.957649E8 4.12E7 1.08 1.89760842E8 3.49E7 0.98 1.4589 0.9989 3188901 PK04_102200 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K01 compound treatment 1.66463745E8 1.19E7 0.31 1.7832194E8 2.35E7 0.66 0.6886 0.9414 3069787 PK04_102201 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(CCO)nn2)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K02 compound treatment 3.5805709E7 -1.19E8 -3.11 3.7987063E7 -1.17E8 -3.29 -4.5263 -0.9996 3188902 PK04_102202 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K03 compound treatment 1.27746347E8 -2.68E7 -0.7 1.36715566E8 -1.81E7 -0.51 -0.8571 -0.988 3188903 PK04_102203 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K04 compound treatment 4.9297305E7 -1.05E8 -2.75 4.8301209E7 -1.07E8 -3.0 -4.071 -0.9991 3069790 PK04_102204 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K05 compound treatment 1.36697414E8 -1.78E7 -0.47 1.26388729E8 -2.85E7 -0.8 -0.8972 -0.9668 3188904 PK04_102205 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K06 compound treatment 2.8273263E7 -1.26E8 -3.3 2.7400694E7 -1.27E8 -3.59 -4.8766 -0.9991 3189012 PK04_102206 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K07 mock treatment 1.3350914E8 -2.1E7 -0.55 1.34830934E8 -2.0E7 -0.56 -0.788 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K08 mock treatment 1.36588744E8 -1.79E7 -0.47 1.50974669E8 -3880000.0 -0.11 -0.4093 -0.849 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K09 compound treatment 7.3090452E7 -8.14E7 -2.13 7.8879393E7 -7.6E7 -2.14 -3.0213 -1.0 3069821 PK04_102207 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K10 compound treatment 8.5677664E7 -6.88E7 -1.8 9.011897E7 -6.47E7 -1.82 -2.5643 -1.0 3189013 PK04_102208 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K11 compound treatment 2.8378814E7 -1.26E8 -3.3 3.0160624E7 -1.25E8 -3.51 -4.8197 -0.9995 3069825 PK04_102209 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K12 compound treatment 2.9256529E7 -1.25E8 -3.28 3.1430304E7 -1.23E8 -3.48 -4.7781 -0.9996 3189014 PK04_102210 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K13 compound treatment 1.24342737E8 -3.02E7 -0.79 1.36094139E8 -1.88E7 -0.53 -0.9325 -0.9809 3189015 PK04_102211 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K14 compound treatment 4.8798776E7 -1.06E8 -2.77 4.4648467E7 -1.1E8 -3.11 -4.153 -0.9983 3069831 PK04_102212 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K15 mock treatment 1.36759416E8 -1.78E7 -0.47 1.30825097E8 -2.4E7 -0.68 -0.8077 -0.9832 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K16 mock treatment 1.43644622E8 -1.09E7 -0.28 1.47966285E8 -6890000.0 -0.19 -0.3387 -0.9825 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K17 compound treatment 3.8735828E7 -1.16E8 -3.03 3.3611023E7 -1.21E8 -3.42 -4.5592 -0.9982 3189016 PK04_102213 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K18 compound treatment 5.7063745E7 -9.75E7 -2.55 4.595713E7 -1.09E8 -3.07 -3.974 -0.9958 3069867 PK04_102214 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K19 compound treatment 5.5048322E7 -9.95E7 -2.6 4.9526531E7 -1.05E8 -2.97 -3.9401 -0.9979 3189017 PK04_102215 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K20 compound treatment 6.9001406E7 -8.55E7 -2.24 6.9318098E7 -8.55E7 -2.41 -3.2875 -0.9993 3069873 PK04_102216 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K21 compound treatment 5.7428186E7 -9.71E7 -2.54 5.4188058E7 -1.01E8 -2.84 -3.8032 -0.9985 3189018 PK04_102217 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K22 compound treatment 9.5570131E7 -5.9E7 -1.54 8.4903099E7 -7.0E7 -1.97 -2.4851 -0.9927 3189019 PK04_102218 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K23 mock treatment 1.80609483E8 2.61E7 0.68 1.79260513E8 2.44E7 0.69 0.9691 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 K24 mock treatment 2.04101248E8 4.96E7 1.3 1.92463119E8 3.76E7 1.06 1.667 0.9949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L01 compound treatment 1.20604568E8 -3.39E7 -0.89 1.27456212E8 -2.74E7 -0.77 -1.1738 -0.9976 3069879 PK04_102219 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L02 compound treatment 1.58554749E8 4030000.0 0.11 1.62110917E8 7260000.0 0.2 0.2192 0.9525 3189020 PK04_102220 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L03 compound treatment 6.3705016E7 -9.08E7 -2.38 6.848588E7 -8.64E7 -2.43 -3.4021 -0.9999 3189021 PK04_102221 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L04 compound treatment 1.47637756E8 -6890000.0 -0.18 1.44243197E8 -1.06E7 -0.3 -0.3389 -0.9707 3069907 PK04_102222 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L05 compound treatment 7.5167668E7 -7.94E7 -2.08 7.1219072E7 -8.36E7 -2.36 -3.1355 -0.998 3189022 PK04_102223 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L06 compound treatment 1.16530331E8 -3.8E7 -0.99 1.13529485E8 -4.13E7 -1.16 -1.5268 -0.9969 3069909 PK04_102224 C[C@@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L07 mock treatment 1.42594876E8 -1.19E7 -0.31 1.53851853E8 -1000000.0 -0.03 -0.2408 -0.7679 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L08 mock treatment 1.38053687E8 -1.65E7 -0.43 1.46562948E8 -8290000.0 -0.23 -0.4701 -0.9586 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L09 compound treatment 3.9801423E7 -1.15E8 -3.0 3.7552371E7 -1.17E8 -3.31 -4.461 -0.9989 3189023 PK04_102225 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L10 compound treatment 1.25011888E8 -2.95E7 -0.77 1.32975538E8 -2.19E7 -0.62 -0.9823 -0.9937 3069912 PK04_102226 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L11 compound treatment 9.4435674E7 -6.01E7 -1.57 1.01186588E8 -5.37E7 -1.51 -2.1817 -0.9998 3189024 PK04_102227 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L12 compound treatment 1.29567641E8 -2.5E7 -0.65 1.3910553E8 -1.57E7 -0.44 -0.7758 -0.9822 3069746 PK04_102228 OCCOc1ccc(cc1)[C@@H](O)CC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L13 compound treatment 6.7685974E7 -8.68E7 -2.27 6.4966399E7 -8.99E7 -2.53 -3.3985 -0.9985 3069917 PK04_102229 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L14 compound treatment 1.29921866E8 -2.46E7 -0.64 1.31784923E8 -2.31E7 -0.65 -0.9151 -1.0 3069920 PK04_102230 O[C@@H](CC=C)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L15 mock treatment 1.33112127E8 -2.14E7 -0.56 1.24835203E8 -3.0E7 -0.85 -0.9945 -0.98 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L16 mock treatment 1.3018518E8 -2.43E7 -0.64 1.35929837E8 -1.89E7 -0.53 -0.8276 -0.9961 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L17 compound treatment 1.30022083E8 -2.45E7 -0.64 1.14991672E8 -3.99E7 -1.12 -1.2479 -0.9647 3189025 PK04_102231 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L18 compound treatment 1.45601447E8 -8930000.0 -0.23 1.44420625E8 -1.04E7 -0.29 -0.3731 -0.9935 3069953 PK04_102232 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L19 compound treatment 5.6474477E7 -9.81E7 -2.57 4.4481287E7 -1.1E8 -3.11 -4.0143 -0.9954 3189026 PK04_102233 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L20 compound treatment 1.63131653E8 8600000.0 0.23 1.60119423E8 5270000.0 0.15 0.2642 0.9795 3069956 PK04_102234 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L21 compound treatment 1.38702855E8 -1.58E7 -0.41 1.26397063E8 -2.85E7 -0.8 -0.8599 -0.9528 3189027 PK04_102235 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L22 compound treatment 1.56424799E8 1900000.0 0.05 1.39448369E8 -1.54E7 -0.43 -0.2718 -0.6221 3069961 PK04_102236 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L23 mock treatment 1.8192137E8 2.74E7 0.72 1.63818777E8 8970000.0 0.25 0.6857 0.9019 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 L24 mock treatment 2.01110252E8 4.66E7 1.22 1.94621922E8 3.98E7 1.12 1.6547 0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M01 compound treatment 3.9794201E7 -1.15E8 -3.0 3.9332527E7 -1.16E8 -3.26 -4.4256 -0.9992 3069962 PK04_102237 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M02 compound treatment 3.284461E7 -1.22E8 -3.19 3.3231301E7 -1.22E8 -3.43 -4.6758 -0.9993 3188628 PK04_102238 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M03 compound treatment 6.5784013E7 -8.87E7 -2.32 7.3373212E7 -8.15E7 -2.3 -3.2662 -1.0 3189028 PK04_102239 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M04 compound treatment 7.9080395E7 -7.54E7 -1.97 7.9906215E7 -7.49E7 -2.11 -2.8899 -0.9994 3189141 PK04_102240 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M05 compound treatment 3.1639871E7 -1.23E8 -3.22 3.1669324E7 -1.23E8 -3.47 -4.7292 -0.9993 3069277 PK04_102241 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M06 compound treatment 3.3632577E7 -1.21E8 -3.16 3.3734304E7 -1.21E8 -3.41 -4.6512 -0.9993 3189142 PK04_102242 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M07 compound treatment 3.5616232E7 -1.19E8 -3.11 3.339072E7 -1.21E8 -3.42 -4.6213 -0.9989 3189143 PK04_102243 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M08 compound treatment 4.67544E7 -1.08E8 -2.82 4.6908895E7 -1.08E8 -3.04 -4.1458 -0.9993 3069284 PK04_102244 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M09 mock treatment 1.4010989E8 -1.44E7 -0.38 1.32969488E8 -2.19E7 -0.62 -0.7029 -0.9722 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M10 mock treatment 1.29783727E8 -2.47E7 -0.65 1.28664642E8 -2.62E7 -0.74 -0.9798 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M11 compound treatment 1.0594338E8 -4.86E7 -1.27 1.16011538E8 -3.88E7 -1.09 -1.6733 -0.9972 3189144 PK04_102245 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M12 compound treatment 5.0256215E7 -1.04E8 -2.73 5.5148218E7 -9.97E7 -2.81 -3.9168 -0.9999 3189145 PK04_102246 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M13 mock treatment 1.32031937E8 -2.25E7 -0.59 1.41489543E8 -1.34E7 -0.38 -0.6827 -0.9767 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M14 mock treatment 1.23472713E8 -3.11E7 -0.81 1.28827763E8 -2.6E7 -0.73 -1.0934 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M15 compound treatment 7.7538683E7 -7.7E7 -2.02 7.5143639E7 -7.97E7 -2.25 -3.0134 -0.9985 3189146 PK04_102247 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M16 compound treatment 7.5705004E7 -7.88E7 -2.06 8.6726358E7 -6.81E7 -1.92 -2.8165 -0.9994 3189147 PK04_102248 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M17 compound treatment 4.6033331E7 -1.08E8 -2.84 3.4369525E7 -1.2E8 -3.4 -4.409 -0.9961 3069327 PK04_102249 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M18 compound treatment 1.27789873E8 -2.67E7 -0.7 1.27270744E8 -2.76E7 -0.78 -1.0445 -0.9986 3189148 PK04_102250 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M19 compound treatment 1.31430386E8 -2.31E7 -0.6 9.7622488E7 -5.72E7 -1.61 -1.5679 -0.9103 3069330 PK04_102251 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M20 compound treatment 5.0559213E7 -1.04E8 -2.72 3.9363991E7 -1.15E8 -3.25 -4.2257 -0.996 3189149 PK04_102252 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M21 compound treatment 5.2639074E7 -1.02E8 -2.67 5.2158532E7 -1.03E8 -2.89 -3.9323 -0.9992 3189150 PK04_102253 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M22 compound treatment 1.35018331E8 -1.95E7 -0.51 1.11289282E8 -4.36E7 -1.23 -1.2292 -0.9245 3189151 PK04_102254 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M23 compound treatment 6.4225593E7 -9.03E7 -2.36 5.58865E7 -9.9E7 -2.79 -3.6435 -0.9966 3189152 PK04_102255 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 M24 compound treatment 2.9000439E7 -1.26E8 -3.29 3.4616188E7 -1.2E8 -3.39 -4.7194 -0.9999 3069375 PK04_102256 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N01 compound treatment 6.0636892E7 -9.39E7 -2.46 5.8714482E7 -9.61E7 -2.71 -3.6536 -0.9988 3189153 PK04_102257 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N02 compound treatment 1.73269265E8 1.87E7 0.49 1.73785391E8 1.89E7 0.53 0.7242 0.9991 3069379 PK04_102258 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N03 compound treatment 1.17039752E8 -3.75E7 -0.98 1.16152281E8 -3.87E7 -1.09 -1.4651 -0.9986 3189154 PK04_102259 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N04 compound treatment 1.45947724E8 -8580000.0 -0.22 1.49801584E8 -5050000.0 -0.14 -0.2595 -0.9758 3069716 PK04_102260 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N05 compound treatment 1.19159509E8 -3.54E7 -0.93 1.15052004E8 -3.98E7 -1.12 -1.4478 -0.9955 3069403 PK04_102261 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N06 compound treatment 1.3834025E8 -1.62E7 -0.42 1.38515536E8 -1.63E7 -0.46 -0.6252 -0.9991 3069417 PK04_102262 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N07 compound treatment 4.6729418E7 -1.08E8 -2.82 4.3111006E7 -1.12E8 -3.15 -4.222 -0.9985 3189155 PK04_102263 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N08 compound treatment 1.28963517E8 -2.56E7 -0.67 1.23069025E8 -3.18E7 -0.9 -1.1065 -0.9897 3069421 PK04_102264 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N09 mock treatment 1.25906128E8 -2.86E7 -0.75 1.32764445E8 -2.21E7 -0.62 -0.9699 -0.9958 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N10 mock treatment 1.17322036E8 -3.72E7 -0.97 1.24950186E8 -2.99E7 -0.84 -1.2845 -0.9974 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N11 compound treatment 4.4669886E7 -1.1E8 -2.88 6.2690478E7 -9.22E7 -2.6 -3.8699 -0.9987 3189156 PK04_102265 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N12 compound treatment 9.9543857E7 -5.5E7 -1.44 1.08181145E8 -4.67E7 -1.32 -1.9477 -0.999 3069424 PK04_102266 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N13 mock treatment 1.21356633E8 -3.32E7 -0.87 1.2335543E8 -3.15E7 -0.89 -1.2416 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N14 mock treatment 1.33055065E8 -2.15E7 -0.56 1.15209025E8 -3.96E7 -1.12 -1.1874 -0.9495 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N15 compound treatment 4.4074472E7 -1.1E8 -2.89 4.2175037E7 -1.13E8 -3.18 -4.2897 -0.9989 3189268 PK04_102267 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N16 compound treatment 1.43882152E8 -1.06E7 -0.28 1.47124772E8 -7730000.0 -0.22 -0.351 -0.9926 3069404 PK04_102268 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N17 compound treatment 1.03845395E8 -5.07E7 -1.33 9.5243103E7 -5.96E7 -1.68 -2.1259 -0.9932 3069428 PK04_102269 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N18 compound treatment 1.31483061E8 -2.3E7 -0.6 1.39926124E8 -1.49E7 -0.42 -0.724 -0.9845 3189269 PK04_102270 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N19 compound treatment 1.25798056E8 -2.87E7 -0.75 1.05270647E8 -4.96E7 -1.4 -1.5198 -0.9578 3070277 PK04_102271 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N20 compound treatment 1.70049616E8 1.55E7 0.41 1.67628889E8 1.28E7 0.36 0.5419 0.9982 3069270 PK04_102272 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N21 compound treatment 4.4396087E7 -1.1E8 -2.88 3.6581192E7 -1.18E8 -3.33 -4.3953 -0.9974 3070278 PK04_102273 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N22 compound treatment 9.4160911E7 -6.04E7 -1.58 8.6918E7 -6.79E7 -1.91 -2.4711 -0.9955 3070279 PK04_102274 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N23 compound treatment 6.0321572E7 -9.42E7 -2.47 4.445049E7 -1.1E8 -3.11 -3.9437 -0.9934 3070280 PK04_102275 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 N24 compound treatment 2.01111654E8 4.66E7 1.22 1.82557669E8 2.77E7 0.78 1.4143 0.9768 3189270 PK04_102276 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O01 compound treatment 1.95167702E8 4.06E7 1.06 2.02401521E8 4.75E7 1.34 1.6997 0.9935 3189271 PK04_102277 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O02 compound treatment 4.0172439E7 -1.14E8 -2.99 4.2182025E7 -1.13E8 -3.18 -4.3618 -0.9996 3070281 PK04_102278 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O03 compound treatment 1.36944602E8 -1.76E7 -0.46 1.45291292E8 -9560000.0 -0.27 -0.516 -0.9675 3189272 PK04_102279 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O04 compound treatment 3.3350437E7 -1.21E8 -3.17 3.0525308E7 -1.24E8 -3.5 -4.7204 -0.9988 3189273 PK04_102280 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O05 compound treatment 5.4477665E7 -1.0E8 -2.62 4.5009344E7 -1.1E8 -3.1 -4.0407 -0.9965 3070282 PK04_102281 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O06 compound treatment 2.8072792E7 -1.26E8 -3.31 2.8641272E7 -1.26E8 -3.56 -4.8556 -0.9994 3189274 PK04_102282 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O07 compound treatment 6.5015756E7 -8.95E7 -2.34 7.0184045E7 -8.47E7 -2.39 -3.344 -1.0 3070283 PK04_102283 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O08 compound treatment 4.4428563E7 -1.1E8 -2.88 4.5559668E7 -1.09E8 -3.08 -4.2157 -0.9994 3189275 PK04_102284 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O09 compound treatment 6.4583884E7 -8.99E7 -2.35 6.1546573E7 -9.33E7 -2.63 -3.5241 -0.9985 3189276 PK04_102285 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O10 compound treatment 5.2125138E7 -1.02E8 -2.68 5.0345989E7 -1.05E8 -2.95 -3.9779 -0.9989 3070284 PK04_102286 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O11 mock treatment 1.19044767E8 -3.55E7 -0.93 1.24911664E8 -2.99E7 -0.84 -1.2534 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O12 mock treatment 1.24663766E8 -2.99E7 -0.78 1.23972332E8 -3.09E7 -0.87 -1.1681 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O13 compound treatment 8.5797241E7 -6.87E7 -1.8 7.4706891E7 -8.01E7 -2.26 -2.8692 -0.9937 3189277 PK04_102287 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4ccccc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O14 compound treatment 8.5337061E7 -6.92E7 -1.81 6.1418664E7 -9.34E7 -2.63 -3.1425 -0.9833 3189278 PK04_102288 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O15 compound treatment 3.4683143E7 -1.2E8 -3.14 2.8675932E7 -1.26E8 -3.56 -4.7326 -0.998 3070285 PK04_102289 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O16 compound treatment 5.6769146E7 -9.78E7 -2.56 4.4280483E7 -1.11E8 -3.12 -4.0128 -0.9952 3189279 PK04_102290 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O17 compound treatment 5.7601034E7 -9.69E7 -2.54 5.0841736E7 -1.04E8 -2.93 -3.8667 -0.9974 3070286 PK04_102291 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O18 compound treatment 5.7173494E7 -9.74E7 -2.55 6.146557E7 -9.34E7 -2.63 -3.6629 -0.9999 3189280 PK04_102292 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O19 compound treatment 4.9480776E7 -1.05E8 -2.75 3.341791E7 -1.21E8 -3.42 -4.3642 -0.9941 3189281 PK04_102293 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O20 compound treatment 8.0729304E7 -7.38E7 -1.93 6.631479E7 -8.85E7 -2.5 -3.1303 -0.992 3070287 PK04_102294 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O21 compound treatment 4.0493348E7 -1.14E8 -2.99 4.1215301E7 -1.14E8 -3.2 -4.3752 -0.9994 3189282 PK04_102295 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O22 compound treatment 5.6952388E7 -9.76E7 -2.55 4.4309834E7 -1.11E8 -3.12 -4.0088 -0.9951 3070288 PK04_102296 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O23 compound treatment 9.9462622E7 -5.51E7 -1.44 5.659386E7 -9.83E7 -2.77 -2.9772 -0.9537 3189283 PK04_102297 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 O24 compound treatment 7.0285496E7 -8.42E7 -2.21 4.8140696E7 -1.07E8 -3.01 -3.6857 -0.9884 3189284 PK04_102298 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P01 compound treatment 4.3370438E7 -1.11E8 -2.91 4.8235816E7 -1.07E8 -3.0 -4.182 -0.9999 3070289 PK04_102299 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P02 compound treatment 1.78379207E8 2.39E7 0.62 1.83106621E8 2.83E7 0.8 1.0045 0.9928 3069953 PK04_102300 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P03 compound treatment 7.2318153E7 -8.22E7 -2.15 7.218422E7 -8.27E7 -2.33 -3.169 -0.9992 3189285 PK04_102301 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P04 compound treatment 1.26119267E8 -2.84E7 -0.74 1.37458656E8 -1.74E7 -0.49 -0.8724 -0.9795 3070290 PK04_102302 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P05 compound treatment 2.8410647E7 -1.26E8 -3.3 2.8793175E7 -1.26E8 -3.55 -4.8463 -0.9993 3189394 PK04_102303 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P06 compound treatment 1.53313401E8 -1210000.0 -0.03 1.6847134E8 1.36E7 0.38 0.2489 0.6464 3069907 PK04_102304 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P07 compound treatment 9.2779024E7 -6.17E7 -1.62 8.6693397E7 -6.82E7 -1.92 -2.5011 -0.9963 3189395 PK04_102305 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P08 compound treatment 1.42488115E8 -1.2E7 -0.32 1.59247403E8 4390000.0 0.12 -0.1353 -0.3995 3069314 PK04_102306 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P09 compound treatment 4.2456789E7 -1.12E8 -2.93 3.8192107E7 -1.17E8 -3.29 -4.3991 -0.9984 3070291 PK04_102307 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P10 compound treatment 1.28147361E8 -2.64E7 -0.69 1.31254299E8 -2.36E7 -0.67 -0.9585 -0.9998 3189396 PK04_102308 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P11 mock treatment 1.26472619E8 -2.81E7 -0.73 1.24275138E8 -3.06E7 -0.86 -1.1286 -0.9968 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P12 mock treatment 1.29229166E8 -2.53E7 -0.66 1.26852307E8 -2.8E7 -0.79 -1.0262 -0.9962 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P13 compound treatment 4.0914508E7 -1.14E8 -2.97 3.8644904E7 -1.16E8 -3.27 -4.4186 -0.9988 3189397 PK04_102309 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P14 compound treatment 1.39773119E8 -1.48E7 -0.39 1.2037847E8 -3.45E7 -0.97 -0.9601 -0.9183 3070292 PK04_102310 OCCOc1ccc(cc1)[C@H](O)CC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P15 compound treatment 5.0963623E7 -1.04E8 -2.71 5.1771076E7 -1.03E8 -2.9 -3.971 -0.9994 3070293 PK04_102311 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P16 compound treatment 1.42548597E8 -1.2E7 -0.31 1.48572744E8 -6280000.0 -0.18 -0.3469 -0.9634 3070292 PK04_102312 OCCOc1ccc(cc1)[C@H](O)CC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P17 compound treatment 9.4732361E7 -5.98E7 -1.57 8.4857958E7 -7.0E7 -1.97 -2.5016 -0.9934 3189398 PK04_102313 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P18 compound treatment 1.41206025E8 -1.33E7 -0.35 1.323024E8 -2.26E7 -0.64 -0.6959 -0.9601 3070294 PK04_102314 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P19 compound treatment 1.21768729E8 -3.28E7 -0.86 1.05664979E8 -4.92E7 -1.39 -1.5865 -0.9733 3189399 PK04_102315 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P20 compound treatment 1.48313008E8 -6210000.0 -0.16 1.46702732E8 -8150000.0 -0.23 -0.2774 -0.9857 3070290 PK04_102316 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P21 compound treatment 6.8195877E7 -8.63E7 -2.26 5.6296666E7 -9.86E7 -2.78 -3.5619 -0.9948 3189400 PK04_102317 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P22 compound treatment 1.73740638E8 1.92E7 0.5 1.75116674E8 2.03E7 0.57 0.7594 0.998 3070295 PK04_102318 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P23 compound treatment 1.16692377E8 -3.78E7 -0.99 8.7034696E7 -6.78E7 -1.91 -2.0517 -0.9532 3189401 PK04_102319 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2102 P24 compound treatment 2.1946492E8 6.49E7 1.7 2.22275255E8 6.74E7 1.9 2.5455 0.9985 3414053 PK04_102320 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A01 compound treatment 2.25028551E8 5.55E7 1.45 2.183223E8 3.97E7 1.12 1.818 0.9917 3213058 Ald1-H_001230 NNC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A02 compound treatment 2.19979809E8 5.04E7 1.32 2.17443819E8 3.88E7 1.09 1.7071 0.9957 3213059 Ald1-H_001231 NNC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A03 compound treatment 1.00833398E8 -6.87E7 -1.8 1.02890547E8 -7.57E7 -2.13 -2.7809 -0.9964 3213060 Ald1-H_001232 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1OCC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A04 compound treatment 2.18837516E8 4.93E7 1.29 2.16918803E8 3.83E7 1.08 1.6755 0.9961 3213062 Ald1-H_001233 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccc2OCC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A05 compound treatment 7.2431515E7 -9.71E7 -2.54 6.6668713E7 -1.12E8 -3.15 -4.0284 -0.9943 3213064 Ald1-H_001234 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A06 compound treatment 2.01104199E8 3.15E7 0.83 1.97351958E8 1.87E7 0.53 0.9573 0.9767 3213066 Ald1-H_001235 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A07 compound treatment 4.6062882E7 -1.24E8 -3.23 6.7924353E7 -1.11E8 -3.12 -4.4915 -0.9998 3213068 Ald1-H_001236 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A08 compound treatment 1.99636907E8 3.01E7 0.79 2.05732122E8 2.71E7 0.76 1.0972 0.9999 3213070 Ald1-H_001237 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A09 compound treatment 4.0805093E7 -1.29E8 -3.37 5.3147762E7 -1.25E8 -3.54 -4.8833 -0.9997 3213072 Ald1-H_001238 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc2OCCOc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A10 compound treatment 1.88516561E8 1.9E7 0.5 2.01854204E8 2.33E7 0.66 0.8141 0.9906 3213074 Ald1-H_001239 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc3OCCOc3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A11 compound treatment 1.89975549E8 2.04E7 0.53 1.79184733E8 581000.0 0.02 0.3893 0.7284 3213076 Ald1-H_001240 ONC(=O)CCCCCCC(=O)N/N=C/COCc1ccccc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A12 compound treatment 2.07941576E8 3.84E7 1.0 1.93576286E8 1.5E7 0.42 1.0087 0.9258 3213078 Ald1-H_001241 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/COCc2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A13 mock treatment 2.02628907E8 3.31E7 0.87 2.13911919E8 3.53E7 0.99 1.3155 0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A14 mock treatment 2.01272572E8 3.17E7 0.83 1.85915698E8 7310000.0 0.21 0.7326 0.8567 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A15 compound treatment 4.8308325E7 -1.21E8 -3.17 6.4556413E7 -1.14E8 -3.21 -4.517 -1.0 3213080 Ald1-H_001242 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)c2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A16 compound treatment 1.44057542E8 -2.55E7 -0.67 1.58794495E8 -1.98E7 -0.56 -0.8669 -0.996 3213082 Ald1-H_001243 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(cc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A17 compound treatment 3.3875278E7 -1.36E8 -3.55 3.2842859E7 -1.46E8 -4.11 -5.4161 -0.9974 3213084 Ald1-H_001244 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A18 compound treatment 1.59334825E8 -1.02E7 -0.27 1.88737797E8 1.01E7 0.29 0.0126 0.0321 3213086 Ald1-H_001245 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccc2Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A19 compound treatment 1.90587799E8 2.1E7 0.55 1.72814533E8 -5790000.0 -0.16 0.2737 0.4769 3213088 Ald1-H_001246 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc(Br)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A20 compound treatment 2.15520053E8 4.6E7 1.2 2.06364685E8 2.78E7 0.78 1.4038 0.9783 3213090 Ald1-H_001247 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccc(Br)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A21 compound treatment 1.27352341E8 -4.22E7 -1.11 1.34534688E8 -4.41E7 -1.24 -1.6595 -0.9983 3213092 Ald1-H_001248 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(Br)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A22 compound treatment 1.66191439E8 -3370000.0 -0.09 1.61433743E8 -1.72E7 -0.48 -0.4046 -0.8226 3213094 Ald1-H_001249 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(Br)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A23 compound treatment 1.39573211E8 -3.0E7 -0.79 1.28622147E8 -5.0E7 -1.41 -1.5511 -0.9619 3213096 Ald1-H_001250 ONC(=O)CCCCCCC(=O)N/N=C/C(=C/c1ccccc1)/Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 A24 compound treatment 1.45166318E8 -2.44E7 -0.64 1.36515061E8 -4.21E7 -1.19 -1.2903 -0.9578 3213098 Ald1-H_001251 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/C(=C/c2ccccc2)/Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B01 compound treatment 1.75945675E8 6380000.0 0.17 1.64929965E8 -1.37E7 -0.39 -0.1544 -0.3676 3213100 Ald1-H_001252 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2c(O)ccc3ccccc23 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B02 compound treatment 5.2940042E7 -1.17E8 -3.05 4.4278446E7 -1.34E8 -3.79 -4.8354 -0.9943 3213102 Ald1-H_001253 ONC(=O)CCCCCCC(=O)N/N=C/c1c(O)ccc2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B03 compound treatment 1.92237996E8 2.27E7 0.59 1.76304742E8 -2300000.0 -0.06 0.3738 0.6262 3213104 Ald1-H_001254 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(O)c3ccccc23 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B04 compound treatment 1.45181876E8 -2.44E7 -0.64 1.34185424E8 -4.44E7 -1.25 -1.3365 -0.9512 3213106 Ald1-H_001255 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B05 compound treatment 1.84832509E8 1.53E7 0.4 1.84148279E8 5540000.0 0.16 0.3931 0.916 3213108 Ald1-H_001256 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc([N+](=O)[O-])c(O)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B06 compound treatment 1.66417685E8 -3150000.0 -0.08 1.58245037E8 -2.04E7 -0.57 -0.464 -0.8005 3213110 Ald1-H_001257 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc([N+](=O)[O-])c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B07 compound treatment 1.76570766E8 7000000.0 0.18 1.86731714E8 8130000.0 0.23 0.2916 0.9939 3213112 Ald1-H_001258 Oc1ccc([N+](=O)[O-])c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B08 compound treatment 1.81736957E8 1.22E7 0.32 1.7236783E8 -6240000.0 -0.18 0.101 0.2776 3213114 Ald1-H_001259 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(O)ccc1[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B09 compound treatment 1.73012669E8 3450000.0 0.09 1.82338676E8 3730000.0 0.11 0.1382 0.9971 3213116 Ald1-H_001260 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(cc2)n3ccnc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B10 compound treatment 1.13452855E8 -5.61E7 -1.47 1.40591628E8 -3.8E7 -1.07 -1.7961 -0.988 3213118 Ald1-H_001261 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)n2ccnc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B11 compound treatment 1.83312263E8 1.37E7 0.36 1.64100675E8 -1.45E7 -0.41 -0.0346 -0.0635 3213120 Ald1-H_001262 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2c[nH]c3ccccc23 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B12 compound treatment 6.8227207E7 -1.01E8 -2.65 7.0958615E7 -1.08E8 -3.03 -4.0208 -0.9978 3213122 Ald1-H_001263 ONC(=O)CCCCCCC(=O)N/N=C/c1c[nH]c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B13 mock treatment 1.88954073E8 1.94E7 0.51 1.63406027E8 -1.52E7 -0.43 0.056 0.0844 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B14 mock treatment 1.85995746E8 1.64E7 0.43 1.64469206E8 -1.41E7 -0.4 0.0224 0.0383 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B15 compound treatment 1.46845944E8 -2.27E7 -0.59 1.72543551E8 -6060000.0 -0.17 -0.5413 -0.8748 3213124 Ald1-H_001264 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(I)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B16 compound treatment 3.5405928E7 -1.34E8 -3.51 5.2497821E7 -1.26E8 -3.55 -4.9961 -1.0 3213126 Ald1-H_001265 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(I)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B17 compound treatment 1.77069872E8 7500000.0 0.2 1.60389465E8 -1.82E7 -0.51 -0.2241 -0.4077 3213128 Ald1-H_001266 C/C=C(/C)\C=N\NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B18 compound treatment 7.8858842E7 -9.07E7 -2.37 8.453854E7 -9.41E7 -2.65 -3.5534 -0.9985 3213130 Ald1-H_001267 C/C=C(/C)\C=N\NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B19 compound treatment 1.80612956E8 1.1E7 0.29 1.68157116E8 -1.04E7 -0.29 -0.0037 -0.009 3213132 Ald1-H_001268 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccc2[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B20 compound treatment 9.8135888E7 -7.14E7 -1.87 8.0848622E7 -9.78E7 -2.75 -3.2701 -0.9822 3213134 Ald1-H_001269 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B21 compound treatment 1.93244486E8 2.37E7 0.62 1.84294919E8 5690000.0 0.16 0.5517 0.8617 3213136 Ald1-H_001270 Cc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B22 compound treatment 1.26736497E8 -4.28E7 -1.12 1.24179688E8 -5.44E7 -1.53 -1.8773 -0.9881 3213138 Ald1-H_001271 Cc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B23 compound treatment 2.09354218E8 3.98E7 1.04 1.9694453E8 1.83E7 0.52 1.1019 0.9477 3213140 Ald1-H_001272 Cc1[nH]cnc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 B24 compound treatment 2.06471444E8 3.69E7 0.97 2.00846267E8 2.22E7 0.63 1.1263 0.9781 3213142 Ald1-H_001273 Cc1[nH]cnc1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C01 compound treatment 1.81220871E8 1.17E7 0.31 1.73077037E8 -5530000.0 -0.16 0.1056 0.3083 3213144 Ald1-H_001274 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(Br)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C02 compound treatment 1.89046394E8 1.95E7 0.51 1.81160175E8 2560000.0 0.07 0.4115 0.7991 3213146 Ald1-H_001275 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(Br)o2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C03 compound treatment 3.4227205E7 -1.35E8 -3.54 3.4471608E7 -1.44E8 -4.06 -5.3772 -0.9977 3213148 Ald1-H_001276 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)cc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C04 compound treatment 1.75836435E8 6270000.0 0.16 1.62627436E8 -1.6E7 -0.45 -0.2023 -0.4222 3213150 Ald1-H_001277 Oc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(Br)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C05 compound treatment 3.4020311E7 -1.36E8 -3.55 3.4431602E7 -1.44E8 -4.06 -5.3818 -0.9977 3213152 Ald1-H_001278 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(O)ccc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C06 compound treatment 1.68979358E8 -587000.0 -0.02 1.78549397E8 -54400.0 0.0 -0.012 -0.7738 3213154 Ald1-H_001279 Oc1ccc(Br)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C07 compound treatment 7.6398825E7 -9.32E7 -2.44 8.431422E7 -9.43E7 -2.66 -3.6034 -0.9991 3213156 Ald1-H_001280 COc1cc(Br)cc(/C=N/NC(=O)CCCCCCC(=O)NO)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C08 compound treatment 1.54906544E8 -1.47E7 -0.38 1.51354621E8 -2.72E7 -0.77 -0.8143 -0.9486 3213158 Ald1-H_001281 COc1cc(Br)cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C09 compound treatment 3.4638451E7 -1.35E8 -3.53 3.2932944E7 -1.46E8 -4.11 -5.4002 -0.9972 3213160 Ald1-H_001282 COc1ccc(Br)c(/C=N/NC(=O)CCCCCCC(=O)NO)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C10 compound treatment 1.28784335E8 -4.08E7 -1.07 1.49747867E8 -2.89E7 -0.81 -1.3299 -0.991 3213162 Ald1-H_001283 COc1ccc(Br)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C11 mock treatment 1.81462319E8 1.19E7 0.31 1.87805478E8 9200000.0 0.26 0.4035 0.9959 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C12 mock treatment 1.79707447E8 1.01E7 0.27 1.83717818E8 5110000.0 0.14 0.2896 0.9588 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C13 compound treatment 6.0103025E7 -1.09E8 -2.87 8.7024807E7 -9.16E7 -2.58 -3.851 -0.9986 3213164 Ald1-H_001284 COc1ccc(Br)cc1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C14 compound treatment 1.53255169E8 -1.63E7 -0.43 1.55380412E8 -2.32E7 -0.65 -0.7647 -0.9786 3213166 Ald1-H_001285 COc1ccc(Br)cc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C15 mock treatment 1.78060684E8 8490000.0 0.22 1.77943442E8 -660000.0 -0.02 0.1441 0.6457 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C16 mock treatment 1.7669548E8 7130000.0 0.19 1.73410154E8 -5190000.0 -0.15 0.0285 0.12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C17 compound treatment 3.4226002E7 -1.35E8 -3.54 3.2379584E7 -1.46E8 -4.12 -5.4189 -0.9972 3213168 Ald1-H_001286 ONC(=O)CCCCCCC(=O)N/N=C/c1cc2OCOc2cc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C18 compound treatment 1.3999181E8 -2.96E7 -0.77 1.56019313E8 -2.26E7 -0.64 -0.9975 -0.9953 3213170 Ald1-H_001287 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc3OCOc3cc2Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C19 compound treatment 3.4882141E7 -1.35E8 -3.53 3.3056321E7 -1.46E8 -4.1 -5.3932 -0.9972 3213172 Ald1-H_001288 ONC(=O)CCCCCCC(=O)N/N=C/c1cccnc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C20 compound treatment 1.75993074E8 6430000.0 0.17 1.71551925E8 -7050000.0 -0.2 -0.0216 -0.0828 3213174 Ald1-H_001289 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccnc2Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C21 compound treatment 3.9106266E7 -1.3E8 -3.42 3.7056844E7 -1.42E8 -3.99 -5.2353 -0.997 3213176 Ald1-H_001290 ONC(=O)CCCCCCC(=O)N/N=C/c1ccncc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C22 compound treatment 1.39604942E8 -3.0E7 -0.78 1.31321681E8 -4.73E7 -1.33 -1.4968 -0.9681 3213178 Ald1-H_001291 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccncc2Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C23 compound treatment 4.3927192E7 -1.26E8 -3.29 4.1236681E7 -1.37E8 -3.87 -5.0628 -0.9967 3213180 Ald1-H_001292 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(Br)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 C24 compound treatment 1.08205049E8 -6.14E7 -1.61 1.03132201E8 -7.55E7 -2.13 -2.6397 -0.9904 3213182 Ald1-H_001293 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(Br)ccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D01 compound treatment 2.02800076E8 3.32E7 0.87 1.96572988E8 1.8E7 0.51 0.9732 0.9668 3213184 Ald1-H_001294 Cc1ccsc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D02 compound treatment 3.6784604E7 -1.33E8 -3.48 3.7276804E7 -1.41E8 -3.98 -5.2739 -0.9977 3213186 Ald1-H_001295 Cc1ccsc1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D03 compound treatment 9.4567098E7 -7.5E7 -1.96 1.1910745E8 -5.95E7 -1.68 -2.5738 -0.9969 3213188 Ald1-H_001296 CC1(C)[C@@H]2C[C@H]1C(=CC2)/C=N/NC(=O)CCCCCCC(=O)Nc3ccccc3O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D04 compound treatment 8.4437556E7 -8.51E7 -2.23 1.04456908E8 -7.41E7 -2.09 -3.0532 -0.9995 3213190 Ald1-H_001297 CC1(C)[C@@H]2C[C@H]1C(=CC2)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D05 compound treatment 1.62449595E8 -7120000.0 -0.19 1.69493145E8 -9110000.0 -0.26 -0.3133 -0.9876 3213192 Ald1-H_001298 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccc3ccccc23 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D06 compound treatment 3.7901955E7 -1.32E8 -3.45 4.4640201E7 -1.34E8 -3.78 -5.1065 -0.999 3213194 Ald1-H_001299 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D07 compound treatment 1.77350288E8 7780000.0 0.2 1.84880378E8 6280000.0 0.18 0.2691 0.9975 3213196 Ald1-H_001300 COc1cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(cc1OC)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D08 compound treatment 3.9830612E7 -1.3E8 -3.4 5.6012685E7 -1.23E8 -3.45 -4.8442 -1.0 3213198 Ald1-H_001301 COc1cc(/C=N/NC(=O)CCCCCCC(=O)NO)c(cc1OC)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D09 compound treatment 1.4771771E8 -2.18E7 -0.57 1.69714716E8 -8890000.0 -0.25 -0.5815 -0.9314 3213200 Ald1-H_001302 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc3ccccc3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D10 compound treatment 3.5803842E7 -1.34E8 -3.5 3.5491247E7 -1.43E8 -4.03 -5.3277 -0.9975 3213202 Ald1-H_001303 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc2ccccc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D11 mock treatment 1.72956737E8 3390000.0 0.09 1.84895027E8 6290000.0 0.18 0.1881 0.9488 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D12 mock treatment 1.846307E8 1.51E7 0.39 1.81479922E8 2880000.0 0.08 0.3361 0.835 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D13 compound treatment 1.78444557E8 8880000.0 0.23 1.83423757E8 4820000.0 0.14 0.2604 0.9673 3213204 Ald1-H_001304 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(s2)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D14 compound treatment 3.4986539E7 -1.35E8 -3.52 3.3646759E7 -1.45E8 -4.08 -5.3795 -0.9973 3213206 Ald1-H_001305 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(s1)[N+](=O)[O-] 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D15 mock treatment 1.72984487E8 3420000.0 0.09 1.81238062E8 2630000.0 0.07 0.1158 0.9957 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D16 mock treatment 1.81378714E8 1.18E7 0.31 1.87118674E8 8510000.0 0.24 0.3883 0.9921 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D17 compound treatment 1.59183727E8 -1.04E7 -0.27 1.72098458E8 -6510000.0 -0.18 -0.3218 -0.9816 3213208 Ald1-H_001306 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2c(F)c(F)c(F)c(F)c2F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D18 compound treatment 1.36321395E8 -3.32E7 -0.87 1.47273987E8 -3.13E7 -0.88 -1.2397 -1.0 3213210 Ald1-H_001307 ONC(=O)CCCCCCC(=O)N/N=C/c1c(F)c(F)c(F)c(F)c1F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D19 compound treatment 1.76098579E8 6530000.0 0.17 1.81756539E8 3150000.0 0.09 0.1837 0.9535 3213212 Ald1-H_001308 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/CCC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D20 compound treatment 1.71015564E8 1450000.0 0.04 1.69150587E8 -9450000.0 -0.27 -0.1615 -0.6004 3213214 Ald1-H_001309 ONC(=O)CCCCCCC(=O)N/N=C/CCC=C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D21 compound treatment 1.59421337E8 -1.01E7 -0.27 1.52867112E8 -2.57E7 -0.73 -0.7006 -0.9071 3213216 Ald1-H_001310 CC(=C)[C@H]1CCC(=CC1)/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D22 compound treatment 1.2224645E8 -4.73E7 -1.24 1.06037561E8 -7.26E7 -2.04 -2.3219 -0.9712 3213218 Ald1-H_001311 CC(=C)[C@H]1CCC(=CC1)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D23 compound treatment 1.04003498E8 -6.56E7 -1.72 1.14575514E8 -6.4E7 -1.8 -2.4894 -0.9997 3213220 Ald1-H_001312 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccc(Oc3ccccc3)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 D24 compound treatment 1.47796146E8 -2.18E7 -0.57 1.37742667E8 -4.09E7 -1.15 -1.2172 -0.9474 3213222 Ald1-H_001313 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc(Oc2ccccc2)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E01 mock treatment 2.12747915E8 4.32E7 1.13 1.95843388E8 1.72E7 0.49 1.1428 0.9289 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E02 mock treatment 1.86739724E8 1.72E7 0.45 1.89496051E8 1.09E7 0.31 0.5349 0.9827 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E03 compound treatment 4.4187847E7 -1.25E8 -3.28 4.821444E7 -1.3E8 -3.67 -4.9189 -0.9984 3213224 Ald1-H_001314 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(Br)s1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E04 compound treatment 1.66710746E8 -2860000.0 -0.07 1.63576218E8 -1.5E7 -0.42 -0.3523 -0.8193 3213226 Ald1-H_001315 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(Br)s2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E05 compound treatment 3.3281032E7 -1.36E8 -3.57 3.401835E7 -1.45E8 -4.07 -5.4037 -0.9978 3213228 Ald1-H_001316 COc1cc(/C=N/NC(=O)CCCCCCC(=O)NO)c(Br)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E06 compound treatment 1.7982172E8 1.03E7 0.27 1.81651798E8 3050000.0 0.09 0.2506 0.889 3213230 Ald1-H_001317 COc1cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(Br)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E07 compound treatment 1.13129293E8 -5.64E7 -1.48 1.13526062E8 -6.51E7 -1.83 -2.3414 -0.9943 3213232 Ald1-H_001318 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(OCc2ccccc2)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E08 compound treatment 9.1304581E7 -7.83E7 -2.05 9.9756611E7 -7.88E7 -2.22 -3.0198 -0.9992 3213234 Ald1-H_001319 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(OCc3ccccc3)cc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E09 mock treatment 1.76399127E8 6830000.0 0.18 1.86042456E8 7440000.0 0.21 0.2747 0.9969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E10 mock treatment 1.74969133E8 5400000.0 0.14 1.85909688E8 7310000.0 0.21 0.2456 0.9832 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E11 compound treatment 1.36125813E8 -3.34E7 -0.88 1.45004192E8 -3.36E7 -0.95 -1.2885 -0.9992 3213236 Ald1-H_001320 CC(C)(C)OC(=O)NC1(CCCC1)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E12 compound treatment 1.76487105E8 6920000.0 0.18 1.79269414E8 666000.0 0.02 0.1414 0.7762 3213238 Ald1-H_001321 CC(C)(C)OC(=O)NC1(CCCC1)/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E13 compound treatment 1.56957382E8 -1.26E7 -0.33 1.64501568E8 -1.41E7 -0.4 -0.5144 -0.9957 3213240 Ald1-H_001322 CC(C)(C)OC(=O)N1CCC[C@H]1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E14 compound treatment 1.73230803E8 3660000.0 0.1 1.81570298E8 2970000.0 0.08 0.1269 0.9977 3213242 Ald1-H_001323 CC(C)(C)OC(=O)N1CCC[C@H]1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E15 compound treatment 3.976951E7 -1.3E8 -3.4 5.1686133E7 -1.27E8 -3.58 -4.9315 -0.9997 3213244 Ald1-H_001324 CC(C)(C)OC(=O)Nc1cccc(/C=N/NC(=O)CCCCCCC(=O)NO)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E16 compound treatment 1.41529815E8 -2.8E7 -0.73 1.56189714E8 -2.24E7 -0.63 -0.9656 -0.9972 3213246 Ald1-H_001325 CC(C)(C)OC(=O)Nc1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E17 mock treatment 1.71000806E8 1430000.0 0.04 1.8447474E8 5870000.0 0.17 0.1435 0.8461 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E18 mock treatment 1.75382509E8 5820000.0 0.15 1.87606677E8 9000000.0 0.25 0.2871 0.9702 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E19 compound treatment 1.81380101E8 1.18E7 0.31 1.79558582E8 955000.0 0.03 0.2377 0.7657 3213248 Ald1-H_001326 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc(c1)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E20 compound treatment 1.82260715E8 1.27E7 0.33 1.81903546E8 3300000.0 0.09 0.3007 0.8715 3213250 Ald1-H_001327 OC(=O)c1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E21 compound treatment 1.77817306E8 8250000.0 0.22 1.74965246E8 -3640000.0 -0.1 0.0802 0.3355 3213252 Ald1-H_001328 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E22 compound treatment 1.93065057E8 2.35E7 0.62 1.88827385E8 1.02E7 0.29 0.6387 0.9403 3213254 Ald1-H_001329 OC(=O)c1ccccc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E23 compound treatment 1.95227756E8 2.57E7 0.67 1.85570534E8 6970000.0 0.2 0.6138 0.8771 3213256 Ald1-H_001330 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 E24 compound treatment 2.19755585E8 5.02E7 1.31 2.02748328E8 2.41E7 0.68 1.4101 0.9531 3213258 Ald1-H_001331 OC(=O)c1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F01 mock treatment 2.00152451E8 3.06E7 0.8 2.09787014E8 3.12E7 0.88 1.1875 0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F02 mock treatment 1.95590398E8 2.6E7 0.68 1.87878938E8 9280000.0 0.26 0.6665 0.9135 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F03 compound treatment 1.24498607E8 -4.51E7 -1.18 1.33832489E8 -4.48E7 -1.26 -1.7263 -0.9994 3213260 Ald1-H_001332 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cn(c3ccccc23)S(=O)(=O)c4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F04 compound treatment 1.1668205E8 -5.29E7 -1.38 1.09676488E8 -6.89E7 -1.94 -2.3524 -0.9862 3213262 Ald1-H_001333 ONC(=O)CCCCCCC(=O)N/N=C/c1cn(c2ccccc12)S(=O)(=O)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F05 compound treatment 1.64889186E8 -4680000.0 -0.12 1.77330871E8 -1270000.0 -0.04 -0.1119 -0.8774 3213264 Ald1-H_001334 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccn2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F06 compound treatment 1.14541407E8 -5.5E7 -1.44 8.9914343E7 -8.87E7 -2.5 -2.7858 -0.9657 3213266 Ald1-H_001335 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccn1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F07 compound treatment 1.59488396E8 -1.01E7 -0.26 1.76886369E8 -1720000.0 -0.05 -0.2208 -0.8231 3213268 Ald1-H_001336 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccnc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F08 compound treatment 1.05334028E8 -6.42E7 -1.68 1.21829111E8 -5.68E7 -1.6 -2.3203 -0.9997 3213270 Ald1-H_001337 ONC(=O)CCCCCCC(=O)N/N=C/c1cccnc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F09 mock treatment 1.67219854E8 -2350000.0 -0.06 1.81718013E8 3110000.0 0.09 0.0186 0.1738 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F10 mock treatment 1.60888127E8 -8680000.0 -0.23 1.81409793E8 2810000.0 0.08 -0.1047 -0.4354 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F11 compound treatment 1.62233645E8 -7330000.0 -0.19 1.74425305E8 -4180000.0 -0.12 -0.219 -0.9725 3213272 Ald1-H_001338 Cc1ncc(CO)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F12 compound treatment 1.56107315E8 -1.35E7 -0.35 1.71709845E8 -6890000.0 -0.19 -0.3865 -0.9606 3213274 Ald1-H_001339 Cc1ncc(CO)c(/C=N/NC(=O)CCCCCCC(=O)NO)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F13 compound treatment 9.8403283E7 -7.12E7 -1.86 1.15948491E8 -6.27E7 -1.77 -2.5657 -0.9996 3213276 Ald1-H_001340 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc[nH]2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F14 compound treatment 1.38647847E8 -3.09E7 -0.81 1.52213706E8 -2.64E7 -0.74 -1.0982 -0.9991 3213278 Ald1-H_001341 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc[nH]1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F15 compound treatment 1.67235249E8 -2330000.0 -0.06 1.720408E8 -6560000.0 -0.18 -0.1739 -0.8931 3213280 Ald1-H_001342 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(cc2)N3CCCC3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F16 compound treatment 6.374666E7 -1.06E8 -2.77 6.562548E7 -1.13E8 -3.18 -4.21 -0.9976 3213282 Ald1-H_001343 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)N2CCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F17 mock treatment 1.72659979E8 3090000.0 0.08 1.75123823E8 -3480000.0 -0.1 -0.0121 -0.095 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F18 mock treatment 1.735444E8 3980000.0 0.1 1.82482834E8 3880000.0 0.11 0.1509 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F19 compound treatment 1.67739893E8 -1830000.0 -0.05 1.72372867E8 -6230000.0 -0.18 -0.158 -0.868 3213284 Ald1-H_001344 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F20 compound treatment 5.9781193E7 -1.1E8 -2.87 6.2631709E7 -1.16E8 -3.27 -4.343 -0.9979 3213286 Ald1-H_001345 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F21 compound treatment 1.77162073E8 7600000.0 0.2 1.65293768E8 -1.33E7 -0.38 -0.1246 -0.2936 3213288 Ald1-H_001346 CCCCCCC/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F22 compound treatment 1.71579077E8 2010000.0 0.05 1.64744939E8 -1.39E7 -0.39 -0.2389 -0.6062 3213290 Ald1-H_001347 CCCCCCC/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F23 compound treatment 1.94841958E8 2.53E7 0.66 1.78053681E8 -550000.0 -0.02 0.4569 0.6903 3213292 Ald1-H_001348 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2nccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 F24 compound treatment 1.85119662E8 1.56E7 0.41 1.7829398E8 -310000.0 -0.01 0.2817 0.6918 3213294 Ald1-H_001349 ONC(=O)CCCCCCC(=O)N/N=C/c1nccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G01 compound treatment 4.2180991E7 -1.27E8 -3.33 4.711829E7 -1.31E8 -3.71 -4.9779 -0.9986 3213296 Ald1-H_001350 ONC(=O)CCCCCCC(=O)N/N=C/c1ccccc1Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G02 compound treatment 1.57212166E8 -1.24E7 -0.32 1.6635117E8 -1.23E7 -0.35 -0.4728 -0.9995 3213298 Ald1-H_001351 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccccc2Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G03 mock treatment 1.82316492E8 1.28E7 0.33 1.91721917E8 1.31E7 0.37 0.4974 0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G04 mock treatment 1.76854288E8 7290000.0 0.19 1.8664095E8 8040000.0 0.23 0.295 0.9964 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G05 compound treatment 8.3914479E7 -8.57E7 -2.24 9.7531844E7 -8.11E7 -2.28 -3.2009 -1.0 3213300 Ald1-H_001352 ONC(=O)CCCCCCC(=O)N/N=C/c1cccnc1Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G06 compound treatment 1.72901296E8 3330000.0 0.09 1.80557443E8 1950000.0 0.06 0.1007 0.9753 3213302 Ald1-H_001353 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccnc2Cl 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G07 compound treatment 3.3911273E7 -1.36E8 -3.55 3.3427179E7 -1.45E8 -4.09 -5.4038 -0.9975 3213304 Ald1-H_001354 ONC(=O)CCCCCCC(=O)N/N=C/C=C/c1ccccc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G08 compound treatment 1.40331828E8 -2.92E7 -0.77 1.5567783E8 -2.29E7 -0.65 -0.998 -0.9965 3213306 Ald1-H_001355 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/C=C/c2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G09 compound treatment 1.43339887E8 -2.62E7 -0.69 1.62425819E8 -1.62E7 -0.46 -0.8078 -0.9802 3213308 Ald1-H_001356 C[C@H](CCC=C(C)C)C/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G10 compound treatment 1.69157292E8 -409000.0 -0.01 1.83008719E8 4400000.0 0.12 0.0802 0.6437 3213310 Ald1-H_001357 C[C@H](CCC=C(C)C)C/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G11 compound treatment 1.43679184E8 -2.59E7 -0.68 1.63315166E8 -1.53E7 -0.43 -0.7838 -0.9761 3213312 Ald1-H_001358 C[C@@H](CCC=C(C)C)C/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G12 compound treatment 1.58144E8 -1.14E7 -0.3 1.69540972E8 -9060000.0 -0.26 -0.392 -0.9969 3213313 Ald1-H_001359 C[C@@H](CCC=C(C)C)C/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G13 compound treatment 1.16800794E8 -5.28E7 -1.38 1.30785104E8 -4.78E7 -1.35 -1.9295 -0.9999 3213314 Ald1-H_001360 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(C#N)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G14 compound treatment 1.52930684E8 -1.66E7 -0.44 1.71347628E8 -7260000.0 -0.2 -0.4525 -0.9406 3213316 Ald1-H_001361 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(C#N)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G15 compound treatment 1.51564135E8 -1.8E7 -0.47 1.66287366E8 -1.23E7 -0.35 -0.5786 -0.9887 3213318 Ald1-H_001362 ONC(=O)CCCCCCC(=O)N/N=C/C1CCCCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G16 compound treatment 1.53654449E8 -1.59E7 -0.42 1.82049234E8 3450000.0 0.1 -0.2259 -0.5281 3213320 Ald1-H_001363 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/C2CCCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G17 compound treatment 3.879924E7 -1.31E8 -3.42 4.9520554E7 -1.29E8 -3.64 -4.9927 -0.9995 3213322 Ald1-H_001364 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G18 compound treatment 1.48967205E8 -2.06E7 -0.54 1.55515333E8 -2.31E7 -0.65 -0.8414 -0.9956 3213324 Ald1-H_001365 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1Br 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G19 mock treatment 1.65902466E8 -3660000.0 -0.1 1.77884684E8 -719000.0 -0.02 -0.0821 -0.838 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G20 mock treatment 1.75831826E8 6270000.0 0.16 1.82243791E8 3640000.0 0.1 0.1885 0.9745 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G21 compound treatment 1.23560417E8 -4.6E7 -1.2 1.3285665E8 -4.57E7 -1.29 -1.7631 -0.9994 3213326 Ald1-H_001366 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(Br)cc(Br)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G22 compound treatment 1.44430147E8 -2.51E7 -0.66 1.48474928E8 -3.01E7 -0.85 -1.0656 -0.9921 3213328 Ald1-H_001367 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(Br)cc(Br)c2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G23 compound treatment 1.93804164E8 2.42E7 0.63 1.79092933E8 489000.0 0.01 0.4584 0.7223 3213330 Ald1-H_001368 CCCCN(CCCC)c1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 G24 compound treatment 2.14373177E8 4.48E7 1.17 2.02453042E8 2.38E7 0.67 1.3046 0.9651 3213332 Ald1-H_001369 CCCCN(CCCC)c1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H01 compound treatment 1.86932032E8 1.74E7 0.45 1.78881305E8 277000.0 0.01 0.327 0.7192 3213334 Ald1-H_001370 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cccs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H02 compound treatment 3.9882944E7 -1.3E8 -3.39 3.9134019E7 -1.39E8 -3.93 -5.1796 -0.9973 3213336 Ald1-H_001371 ONC(=O)CCCCCCC(=O)N/N=C/c1cccs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H03 mock treatment 1.8463737E8 1.51E7 0.39 1.8154267E8 2940000.0 0.08 0.3375 0.8373 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H04 mock treatment 1.78284299E8 8720000.0 0.23 1.82761999E8 4160000.0 0.12 0.2442 0.952 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H05 compound treatment 1.52271742E8 -1.73E7 -0.45 1.48084673E8 -3.05E7 -0.86 -0.9283 -0.9551 3213338 Ald1-H_001372 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(cc2)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H06 compound treatment 1.05979908E8 -6.36E7 -1.66 1.01993125E8 -7.66E7 -2.16 -2.7036 -0.9917 3213340 Ald1-H_001373 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)C(F)(F)F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H07 compound treatment 1.68806042E8 -760000.0 -0.02 1.78482181E8 -122000.0 0.0 -0.0165 -0.8168 3213342 Ald1-H_001374 Oc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(O)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H08 compound treatment 1.6117878E8 -8390000.0 -0.22 1.77243771E8 -1360000.0 -0.04 -0.1824 -0.8182 3213344 Ald1-H_001375 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)c(O)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H09 compound treatment 1.64919623E8 -4650000.0 -0.12 1.81841485E8 3240000.0 0.09 -0.0215 -0.1414 3213346 Ald1-H_001376 Oc1cc(O)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H10 compound treatment 1.4171372E8 -2.79E7 -0.73 1.68180502E8 -1.04E7 -0.29 -0.7232 -0.9201 3213348 Ald1-H_001377 ONC(=O)CCCCCCC(=O)N/N=C/c1c(O)cc(O)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H11 compound treatment 1.52745547E8 -1.68E7 -0.44 1.72124146E8 -6480000.0 -0.18 -0.4405 -0.924 3213350 Ald1-H_001378 COc1cc(OC)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(OC)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H12 compound treatment 1.39122679E8 -3.04E7 -0.8 1.54521177E8 -2.41E7 -0.68 -1.0434 -0.9968 3213352 Ald1-H_001379 COc1cc(OC)c(/C=N/NC(=O)CCCCCCC(=O)NO)c(OC)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H13 compound treatment 1.5150209E8 -1.81E7 -0.47 1.69959487E8 -8640000.0 -0.24 -0.5066 -0.9524 3213354 Ald1-H_001380 COc1cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc(OC)c1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H14 compound treatment 1.04169947E8 -6.54E7 -1.71 1.21392682E8 -5.72E7 -1.61 -2.3505 -0.9996 3213356 Ald1-H_001381 COc1cc(/C=N/NC(=O)CCCCCCC(=O)NO)cc(OC)c1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H15 compound treatment 1.58773285E8 -1.08E7 -0.28 1.77229031E8 -1370000.0 -0.04 -0.2272 -0.7966 3213358 Ald1-H_001382 CC(C)(C)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H16 compound treatment 1.36291426E8 -3.33E7 -0.87 1.49774773E8 -2.88E7 -0.81 -1.1904 -0.9994 3213360 Ald1-H_001383 CC(C)(C)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H17 compound treatment 1.35096707E8 -3.45E7 -0.9 1.46326254E8 -3.23E7 -0.91 -1.2812 -1.0 3213362 Ald1-H_001384 CC1=C(C/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)C(C)(C)CCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H18 compound treatment 1.29129679E8 -4.04E7 -1.06 1.39400181E8 -3.92E7 -1.1 -1.5297 -0.9998 3213364 Ald1-H_001385 CC1=C(C/C=N/NC(=O)CCCCCCC(=O)NO)C(C)(C)CCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H19 mock treatment 1.64858477E8 -4710000.0 -0.12 1.75174537E8 -3430000.0 -0.1 -0.1555 -0.9928 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H20 mock treatment 1.6843039E8 -1140000.0 -0.03 1.72855539E8 -5750000.0 -0.16 -0.1356 -0.8232 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H21 compound treatment 1.74664088E8 5100000.0 0.13 1.77076511E8 -1530000.0 -0.04 0.0639 0.4559 3213366 Ald1-H_001386 NC(=O)COc1ccccc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H22 compound treatment 1.33834514E8 -3.57E7 -0.94 1.21834078E8 -5.68E7 -1.6 -1.7926 -0.9673 3213368 Ald1-H_001387 NC(=O)COc1ccccc1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H23 compound treatment 1.93861051E8 2.43E7 0.64 1.86179729E8 7580000.0 0.21 0.6007 0.8954 3213370 Ald1-H_001388 NC(=O)COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 H24 compound treatment 1.98654982E8 2.91E7 0.76 1.95918138E8 1.73E7 0.49 0.8834 0.9769 3213372 Ald1-H_001389 NC(=O)COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I01 compound treatment 3.8776194E7 -1.31E8 -3.42 3.8357382E7 -1.4E8 -3.95 -5.2155 -0.9974 3213374 Ald1-H_001390 COc1cc(Cl)c(/C=N/NC(=O)CCCCCCC(=O)NO)c(Cl)c1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I02 compound treatment 8.6992344E7 -8.26E7 -2.16 9.7641263E7 -8.1E7 -2.28 -3.1417 -0.9996 3213376 Ald1-H_001391 COc1cc(Cl)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(Cl)c1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I03 compound treatment 1.39299951E8 -3.03E7 -0.79 1.44675082E8 -3.39E7 -0.96 -1.2363 -0.9956 3213378 Ald1-H_001392 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(Cl)cc(Cl)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I04 compound treatment 1.40309632E8 -2.93E7 -0.77 1.40080915E8 -3.85E7 -1.09 -1.3092 -0.9854 3213380 Ald1-H_001393 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(Cl)cc(Cl)c2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I05 mock treatment 1.65136922E8 -4430000.0 -0.12 1.85037244E8 6430000.0 0.18 0.0462 0.2147 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I06 mock treatment 1.63089684E8 -6480000.0 -0.17 1.85588167E8 6980000.0 0.2 0.0193 0.0743 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I07 compound treatment 1.59248832E8 -1.03E7 -0.27 1.78066746E8 -537000.0 -0.02 -0.2017 -0.7456 3213382 Ald1-H_001394 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(Br)cc([N+](=O)[O-])c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I08 compound treatment 1.59922361E8 -9640000.0 -0.25 1.74356136E8 -4250000.0 -0.12 -0.2632 -0.9419 3213384 Ald1-H_001395 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(Br)cc([N+](=O)[O-])c2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I09 compound treatment 1.1171224E8 -5.79E7 -1.51 1.16318262E8 -6.23E7 -1.76 -2.312 -0.9973 3213386 Ald1-H_001396 CCN(CC)c1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I10 compound treatment 6.684675E7 -1.03E8 -2.69 7.1061888E7 -1.08E8 -3.03 -4.0443 -0.9982 3213388 Ald1-H_001397 CCN(CC)c1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I11 compound treatment 3.8707599E7 -1.31E8 -3.43 3.8076899E7 -1.41E8 -3.96 -5.2224 -0.9974 3213390 Ald1-H_001398 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc2OCCc2c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I12 compound treatment 1.52038564E8 -1.75E7 -0.46 1.72039772E8 -6560000.0 -0.18 -0.4552 -0.9202 3213392 Ald1-H_001399 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc3OCCc3c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I13 compound treatment 1.10538967E8 -5.9E7 -1.55 1.28070734E8 -5.05E7 -1.42 -2.0995 -0.9992 3213394 Ald1-H_001400 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc(O)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I14 compound treatment 1.33850623E8 -3.57E7 -0.93 1.51513478E8 -2.71E7 -0.76 -1.2009 -0.9949 3213396 Ald1-H_001401 Oc1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I15 compound treatment 1.22947691E8 -4.66E7 -1.22 1.35782736E8 -4.28E7 -1.21 -1.7162 -1.0 3213398 Ald1-H_001402 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I16 compound treatment 1.36709848E8 -3.29E7 -0.86 1.53755126E8 -2.48E7 -0.7 -1.1033 -0.9948 3213400 Ald1-H_001403 Oc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I17 compound treatment 1.32491158E8 -3.71E7 -0.97 1.50824158E8 -2.78E7 -0.78 -1.2398 -0.9943 3213402 Ald1-H_001404 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(O)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I18 compound treatment 1.10334597E8 -5.92E7 -1.55 1.25952164E8 -5.27E7 -1.48 -2.1455 -0.9998 3213404 Ald1-H_001405 Oc1ccc(O)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I19 compound treatment 1.58119191E8 -1.14E7 -0.3 1.65179568E8 -1.34E7 -0.38 -0.4794 -0.9933 3213406 Ald1-H_001406 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I20 compound treatment 1.61356797E8 -8210000.0 -0.21 1.83921983E8 5320000.0 0.15 -0.046 -0.1755 3213408 Ald1-H_001407 Oc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I21 mock treatment 1.76669626E8 7100000.0 0.19 1.79884989E8 1280000.0 0.04 0.157 0.8289 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I22 mock treatment 1.79789861E8 1.02E7 0.27 1.82651238E8 4050000.0 0.11 0.2699 0.9277 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I23 compound treatment 1.48296693E8 -2.13E7 -0.56 1.30939922E8 -4.77E7 -1.34 -1.3435 -0.924 3213410 Ald1-H_001408 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)c(OC)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 I24 compound treatment 2.156431E8 4.61E7 1.21 2.14570216E8 3.6E7 1.01 1.5696 0.9963 3213412 Ald1-H_001409 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(OC)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J01 compound treatment 2.03643291E8 3.41E7 0.89 1.92170641E8 1.36E7 0.38 0.9011 0.9285 3213414 Ald1-H_001410 Oc1ccccc1NC(=O)CCCCCCC(=O)NN=C2CCCCCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J02 compound treatment 1.22683344E8 -4.69E7 -1.23 1.54608927E8 -2.4E7 -0.68 -1.3459 -0.9606 3213415 Ald1-H_001411 ONC(=O)CCCCCCC(=O)NN=C1CCCCCCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J03 compound treatment 1.80588523E8 1.1E7 0.29 1.84323875E8 5720000.0 0.16 0.318 0.9622 3213416 Ald1-H_001412 Oc1ccccc1NC(=O)CCCCCCC(=O)NN=C2CCCCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J04 compound treatment 1.42411791E8 -2.72E7 -0.71 1.58408399E8 -2.02E7 -0.57 -0.9051 -0.9939 3213417 Ald1-H_001413 ONC(=O)CCCCCCC(=O)NN=C1CCCCCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J05 mock treatment 1.68992537E8 -574000.0 -0.02 1.70925812E8 -7680000.0 -0.22 -0.1636 -0.7544 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J06 mock treatment 1.62598935E8 -6970000.0 -0.18 1.71585042E8 -7020000.0 -0.2 -0.2688 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J07 compound treatment 1.55108416E8 -1.45E7 -0.38 1.68364655E8 -1.02E7 -0.29 -0.4716 -0.991 3213418 Ald1-H_001414 Oc1ccccc1NC(=O)CCCCCCC(=O)NN=C2CCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J08 compound treatment 1.40176737E8 -2.94E7 -0.77 1.63441378E8 -1.52E7 -0.43 -0.8461 -0.9615 3213419 Ald1-H_001415 ONC(=O)CCCCCCC(=O)NN=C1CCCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J09 mock treatment 1.58504585E8 -1.11E7 -0.29 1.81869782E8 3270000.0 0.09 -0.1397 -0.4597 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J10 mock treatment 1.45552062E8 -2.4E7 -0.63 1.7391617E8 -4690000.0 -0.13 -0.5379 -0.8374 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J11 compound treatment 1.46735142E8 -2.28E7 -0.6 1.58611681E8 -2.0E7 -0.56 -0.821 -0.9996 3213420 Ald1-H_001416 COc1cc(Br)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J12 compound treatment 3.1934059E7 -1.38E8 -3.6 3.1643976E7 -1.47E8 -4.14 -5.4759 -0.9976 3213422 Ald1-H_001417 COc1cc(Br)c(/C=N/NC(=O)CCCCCCC(=O)NO)cc1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J13 compound treatment 1.36299386E8 -3.33E7 -0.87 1.67487031E8 -1.11E7 -0.31 -0.8373 -0.9047 3213424 Ald1-H_001418 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/CCC2CCCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J14 compound treatment 1.33115052E8 -3.65E7 -0.95 1.59172501E8 -1.94E7 -0.55 -1.0619 -0.9652 3213426 Ald1-H_001419 ONC(=O)CCCCCCC(=O)N/N=C/CCC1CCCCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J15 compound treatment 1.09547375E8 -6.0E7 -1.57 1.23269662E8 -5.53E7 -1.56 -2.2136 -1.0 3213428 Ald1-H_001420 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(cc2)N(c3ccccc3)c4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J16 compound treatment 1.29744222E8 -3.98E7 -1.04 1.40879125E8 -3.77E7 -1.06 -1.4888 -1.0 3213430 Ald1-H_001421 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(cc1)N(c2ccccc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J17 compound treatment 1.45964225E8 -2.36E7 -0.62 1.75152348E8 -3450000.0 -0.1 -0.5056 -0.8085 3213432 Ald1-H_001422 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/C[P+](c2ccccc2)(c3ccccc3)c4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J18 compound treatment 1.49693245E8 -1.99E7 -0.52 1.70029115E8 -8570000.0 -0.24 -0.5387 -0.9392 3213434 Ald1-H_001423 ONC(=O)CCCCCCC(=O)N/N=C/C[P+](c1ccccc1)(c2ccccc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J19 mock treatment 1.54118362E8 -1.54E7 -0.4 1.6712967E8 -1.15E7 -0.32 -0.5146 -0.9939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J20 mock treatment 1.63233301E8 -6330000.0 -0.17 1.80349151E8 1750000.0 0.05 -0.0824 -0.4768 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J21 mock treatment 1.7062086E8 1050000.0 0.03 1.7386921E8 -4730000.0 -0.13 -0.0748 -0.5492 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J22 mock treatment 1.88034355E8 1.85E7 0.48 1.84331113E8 5730000.0 0.16 0.456 0.8946 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J23 mock treatment 1.99241256E8 2.97E7 0.78 1.9409944E8 1.55E7 0.44 0.858 0.9629 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 J24 mock treatment 2.10165212E8 4.06E7 1.06 2.04230844E8 2.56E7 0.72 1.2621 0.9823 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K01 compound treatment 1.89317059E8 1.98E7 0.52 1.91317257E8 1.27E7 0.36 0.6189 0.9839 3213436 Ald1-H_001424 COc1cccc(OC)c1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K02 compound treatment 1.87702936E8 1.81E7 0.47 1.80299833E8 1700000.0 0.05 0.3695 0.7744 3213438 Ald1-H_001425 COc1cccc(OC)c1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K03 compound treatment 6.0661593E7 -1.09E8 -2.85 5.3511171E7 -1.25E8 -3.53 -4.5085 -0.9945 3213440 Ald1-H_001426 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K04 compound treatment 1.70019874E8 453000.0 0.01 1.81960582E8 3360000.0 0.09 0.0753 0.7896 3213442 Ald1-H_001427 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1OC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K05 compound treatment 1.4836774E8 -2.12E7 -0.55 1.55015628E8 -2.36E7 -0.66 -0.8624 -0.996 3213444 Ald1-H_001428 COc1cc(O)cc(OC)c1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K06 compound treatment 1.58262099E8 -1.13E7 -0.3 1.73014411E8 -5590000.0 -0.16 -0.3206 -0.9564 3213446 Ald1-H_001429 COc1cc(O)cc(OC)c1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K07 mock treatment 1.53093111E8 -1.65E7 -0.43 1.64207386E8 -1.44E7 -0.41 -0.5918 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K08 mock treatment 1.44775931E8 -2.48E7 -0.65 1.80929056E8 2330000.0 0.07 -0.4125 -0.6325 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K09 compound treatment 1.50969152E8 -1.86E7 -0.49 1.6613843E8 -1.25E7 -0.35 -0.5926 -0.9872 3213448 Ald1-H_001430 CC1(C)COC(CCC/C=N/NC(=O)CCCCCCC(=O)NO)OC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K10 compound treatment 1.49199768E8 -2.04E7 -0.53 1.78916028E8 312000.0 0.01 -0.3708 -0.6953 3213450 Ald1-H_001431 CC1(C)COC(CCC/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)OC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K11 compound treatment 1.56210976E8 -1.34E7 -0.35 1.70080013E8 -8520000.0 -0.24 -0.4171 -0.9832 3213452 Ald1-H_001432 Cc1nnc(Sc2ccc(/C=N/NC(=O)CCCCCCC(=O)NO)o2)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K12 compound treatment 1.52403517E8 -1.72E7 -0.45 1.75858858E8 -2740000.0 -0.08 -0.3724 -0.8168 3213454 Ald1-H_001433 Cc1nnc(Sc2ccc(/C=N/NC(=O)CCCCCCC(=O)Nc3ccccc3O)o2)n1C 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K13 compound treatment 3.9041332E7 -1.31E8 -3.42 3.6150853E7 -1.42E8 -4.01 -5.2546 -0.9968 3213456 Ald1-H_001434 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(Br)cs1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K14 compound treatment 1.31105177E8 -3.85E7 -1.01 1.5198114E8 -2.66E7 -0.75 -1.2424 -0.9895 3213458 Ald1-H_001435 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(Br)cs2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K15 mock treatment 1.39918179E8 -2.96E7 -0.78 1.74021555E8 -4580000.0 -0.13 -0.6401 -0.8136 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K16 mock treatment 1.36574341E8 -3.3E7 -0.86 1.78454222E8 -150000.0 0.0 -0.6137 -0.7105 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K17 compound treatment 1.3673898E8 -3.28E7 -0.86 1.63728103E8 -1.49E7 -0.42 -0.9041 -0.9455 3213460 Ald1-H_001436 CC(C)(C)OC(=O)NC/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K18 compound treatment 1.46093222E8 -2.35E7 -0.61 1.66554276E8 -1.2E7 -0.34 -0.6746 -0.9609 3213462 Ald1-H_001437 CC(C)(C)OC(=O)NC/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K19 compound treatment 3.6074378E7 -1.33E8 -3.49 3.3413557E7 -1.45E8 -4.09 -5.3641 -0.9969 3213464 Ald1-H_001438 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc-2c(Cc3ccccc32)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K20 compound treatment 1.21736674E8 -4.78E7 -1.25 1.26338631E8 -5.23E7 -1.47 -1.9268 -0.9967 3213466 Ald1-H_001439 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc-3c(Cc4ccccc43)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K21 compound treatment 9.5708306E7 -7.39E7 -1.93 8.8714046E7 -8.99E7 -2.53 -3.1583 -0.9911 3213468 Ald1-H_001440 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(F)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K22 compound treatment 1.71636031E8 2070000.0 0.05 1.6927657E8 -9330000.0 -0.26 -0.1476 -0.5498 3213470 Ald1-H_001441 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(F)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K23 mock treatment 1.85147378E8 1.56E7 0.41 1.83326697E8 4720000.0 0.13 0.3825 0.8916 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 K24 mock treatment 2.07512632E8 3.79E7 0.99 2.12658319E8 3.41E7 0.96 1.381 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L01 compound treatment 2.02316541E8 3.28E7 0.86 1.94671983E8 1.61E7 0.45 0.9264 0.9555 3213472 Ald1-H_001442 OC[C@@H](O)[C@@H](O)[C@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L02 compound treatment 1.64228285E8 -5340000.0 -0.14 1.46696579E8 -3.19E7 -0.9 -0.7346 -0.8073 3213474 Ald1-H_001443 OC[C@@H](O)[C@@H](O)[C@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L03 compound treatment 1.85326672E8 1.58E7 0.41 1.82005544E8 3400000.0 0.1 0.3595 0.8488 3213476 Ald1-H_001444 C[C@@H](O)[C@@H](O)[C@@H](O)C/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L04 compound treatment 1.64321505E8 -5240000.0 -0.14 1.5603423E8 -2.26E7 -0.64 -0.5468 -0.8404 3213478 Ald1-H_001445 C[C@@H](O)[C@@H](O)[C@@H](O)C/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L05 compound treatment 1.6243812E8 -7130000.0 -0.19 1.72691348E8 -5910000.0 -0.17 -0.2498 -0.9984 3213480 Ald1-H_001446 OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L06 compound treatment 1.42425388E8 -2.71E7 -0.71 1.5492986E8 -2.37E7 -0.67 -0.9741 -0.9995 3213482 Ald1-H_001447 OC[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L07 mock treatment 1.75428378E8 5860000.0 0.15 1.75490446E8 -3110000.0 -0.09 0.0465 0.2629 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L08 mock treatment 1.51454044E8 -1.81E7 -0.47 1.743808E8 -4220000.0 -0.12 -0.4194 -0.858 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L09 compound treatment 1.4789188E8 -2.17E7 -0.57 1.74485904E8 -4120000.0 -0.12 -0.4832 -0.8345 3213484 Ald1-H_001448 OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L10 compound treatment 1.53874873E8 -1.57E7 -0.41 1.60722853E8 -1.79E7 -0.5 -0.6468 -0.9949 3213485 Ald1-H_001449 OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L11 compound treatment 1.50592375E8 -1.9E7 -0.5 1.70188181E8 -8420000.0 -0.24 -0.5189 -0.9428 3213486 Ald1-H_001450 OC[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L12 compound treatment 1.55582179E8 -1.4E7 -0.37 1.5667244E8 -2.19E7 -0.62 -0.6959 -0.9687 3213487 Ald1-H_001451 OC[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L13 compound treatment 1.52408008E8 -1.72E7 -0.45 1.71138666E8 -7470000.0 -0.21 -0.4664 -0.9403 3213488 Ald1-H_001452 C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L14 compound treatment 1.35569426E8 -3.4E7 -0.89 1.49542137E8 -2.91E7 -0.82 -1.2084 -0.9991 3213490 Ald1-H_001453 C[C@H](O)[C@H](O)[C@@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L15 mock treatment 1.169562E8 -5.26E7 -1.38 1.71564313E8 -7040000.0 -0.2 -1.1141 -0.8007 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L16 mock treatment 1.00188422E8 -6.94E7 -1.82 1.7035828E8 -8250000.0 -0.23 -1.4485 -0.7911 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L17 compound treatment 9.8012786E7 -7.16E7 -1.87 1.22222352E8 -5.64E7 -1.59 -2.4479 -0.9966 3213492 Ald1-H_001454 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(Oc3ccccc3)cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L18 compound treatment 9.4053389E7 -7.55E7 -1.98 9.7424075E7 -8.12E7 -2.29 -3.0154 -0.9974 3213494 Ald1-H_001455 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(Oc2ccccc2)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L19 compound treatment 1.34228638E8 -3.53E7 -0.93 1.77157502E8 -1450000.0 -0.04 -0.6829 -0.7375 3213496 Ald1-H_001456 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc[n+]([O-])cc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L20 compound treatment 1.62907494E8 -6660000.0 -0.17 1.72915326E8 -5690000.0 -0.16 -0.2366 -0.9991 3213498 Ald1-H_001457 ONC(=O)CCCCCCC(=O)N/N=C/c1cc[n+]([O-])cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L21 compound treatment 1.28913447E8 -4.07E7 -1.06 1.18880322E8 -5.97E7 -1.68 -1.9426 -0.9756 3213500 Ald1-H_001458 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc3ccccc3n2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L22 compound treatment 7.3632093E7 -9.59E7 -2.51 3.7777656E7 -1.41E8 -3.97 -4.5819 -0.9756 3213502 Ald1-H_001459 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc2ccccc2n1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L23 mock treatment 1.81026206E8 1.15E7 0.3 1.80958074E8 2350000.0 0.07 0.259 0.8431 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 L24 mock treatment 2.00883805E8 3.13E7 0.82 1.9969198E8 2.11E7 0.59 0.9999 0.9875 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M01 compound treatment 1.69778884E8 212000.0 0.01 1.57788522E8 -2.08E7 -0.59 -0.4108 -0.7004 3213504 Ald1-H_001460 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)c(F)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M02 compound treatment 1.86707839E8 1.71E7 0.45 1.78442393E8 -161000.0 0.0 0.3141 0.6999 3213506 Ald1-H_001461 Oc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1F 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M03 compound treatment 8.3025959E7 -8.65E7 -2.27 6.354206E7 -1.15E8 -3.24 -3.8946 -0.9846 3213508 Ald1-H_001462 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(F)c(Oc2ccccc2)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M04 compound treatment 1.18377408E8 -5.12E7 -1.34 1.13610809E8 -6.5E7 -1.83 -2.2426 -0.9882 3213510 Ald1-H_001463 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(F)c(Oc3ccccc3)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M05 compound treatment 3.3245428E7 -1.36E8 -3.57 3.2365492E7 -1.46E8 -4.12 -5.4373 -0.9974 3213512 Ald1-H_001464 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(F)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M06 compound treatment 1.32890809E8 -3.67E7 -0.96 1.12703622E8 -6.59E7 -1.86 -1.992 -0.9529 3213514 Ald1-H_001465 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(F)ccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M07 compound treatment 1.47967567E8 -2.16E7 -0.57 1.55263864E8 -2.33E7 -0.66 -0.8649 -0.9972 3213516 Ald1-H_001466 ONC(=O)CCCCCCC(=O)N/N=C/c1coc2ccccc2c1=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M08 compound treatment 1.68345575E8 -1220000.0 -0.03 1.81404286E8 2800000.0 0.08 0.0332 0.39 3213518 Ald1-H_001467 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2coc3ccccc3c2=O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M09 mock treatment 1.5998687E8 -9580000.0 -0.25 1.69341208E8 -9260000.0 -0.26 -0.3619 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M10 mock treatment 1.42476382E8 -2.71E7 -0.71 1.71880804E8 -6720000.0 -0.19 -0.6354 -0.8657 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M11 compound treatment 3.7845631E7 -1.32E8 -3.45 3.2475768E7 -1.46E8 -4.12 -5.35 -0.9961 3213520 Ald1-H_001468 CC(C)(C)OC(=O)Nc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M12 compound treatment 1.4211902E8 -2.74E7 -0.72 1.67504159E8 -1.11E7 -0.31 -0.7292 -0.9306 3213522 Ald1-H_001469 CC(C)(C)OC(=O)Nc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M13 mock treatment 1.26232294E8 -4.33E7 -1.13 1.74965296E8 -3640000.0 -0.1 -0.8746 -0.7679 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M14 mock treatment 1.33262456E8 -3.63E7 -0.95 1.61682502E8 -1.69E7 -0.48 -1.0092 -0.9491 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M15 compound treatment 1.18003447E8 -5.16E7 -1.35 1.331874E8 -4.54E7 -1.28 -1.8594 -0.9996 3213524 Ald1-H_001470 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc(c1)B(O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M16 compound treatment 1.3516988E8 -3.44E7 -0.9 1.62722963E8 -1.59E7 -0.45 -0.9531 -0.9479 3213526 Ald1-H_001471 OB(O)c1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M17 compound treatment 4.3818064E7 -1.26E8 -3.29 3.873939E7 -1.4E8 -3.94 -5.1146 -0.996 3213528 Ald1-H_001472 ONC(=O)CCCCCCC(=O)N/N=C/c1ccco1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M18 compound treatment 1.39534383E8 -3.0E7 -0.79 1.6252638E8 -1.61E7 -0.45 -0.8763 -0.9657 3213530 Ald1-H_001473 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccco2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M19 compound treatment 8.5295117E7 -8.43E7 -2.21 7.0523105E7 -1.08E8 -3.05 -3.7135 -0.9875 3213532 Ald1-H_001474 ONC(=O)CCCCCCC(=O)N/N=C/c1ccoc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M20 compound treatment 1.54473741E8 -1.51E7 -0.4 1.52097169E8 -2.65E7 -0.75 -0.8075 -0.9557 3213534 Ald1-H_001475 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccoc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M21 compound treatment 1.17285463E8 -5.23E7 -1.37 9.2898933E7 -8.57E7 -2.42 -2.6755 -0.9638 3213536 Ald1-H_001476 ONC(=O)CCCCCCC(=O)N/N=C/c1cccc(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M22 compound treatment 1.73186673E8 3620000.0 0.09 1.63920039E8 -1.47E7 -0.41 -0.2256 -0.5314 3213538 Ald1-H_001477 Oc1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M23 compound treatment 1.28956819E8 -4.06E7 -1.06 1.07728794E8 -7.09E7 -2.0 -2.164 -0.9564 3213540 Ald1-H_001478 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 M24 compound treatment 1.95547503E8 2.6E7 0.68 1.94579014E8 1.6E7 0.45 0.7992 0.9799 3213542 Ald1-H_001479 Oc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N01 compound treatment 1.6626017E8 -3310000.0 -0.09 1.50001785E8 -2.86E7 -0.81 -0.6311 -0.7786 3213544 Ald1-H_001480 Cc1ccccc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N02 compound treatment 6.259032E7 -1.07E8 -2.8 4.1843387E7 -1.37E8 -3.85 -4.7053 -0.9877 3213546 Ald1-H_001481 Cc1ccccc1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N03 compound treatment 1.74498421E8 4930000.0 0.13 1.70172297E8 -8430000.0 -0.24 -0.0767 -0.2837 3213548 Ald1-H_001482 COc1cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N04 compound treatment 1.2088428E8 -4.87E7 -1.27 1.16159454E8 -6.24E7 -1.76 -2.1454 -0.9874 3213550 Ald1-H_001483 COc1cc(/C=N/NC(=O)CCCCCCC(=O)NO)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N05 compound treatment 1.62028468E8 -7540000.0 -0.2 1.596315E8 -1.9E7 -0.53 -0.5176 -0.9082 3213552 Ald1-H_001484 O[C@@H](/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O)[C@@H](O)[C@@H](O)[C@H](O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N06 compound treatment 1.4695443E8 -2.26E7 -0.59 1.45897464E8 -3.27E7 -0.92 -1.0703 -0.9771 3213554 Ald1-H_001485 ONC(=O)CCCCCCC(=O)N/N=C/[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N07 compound treatment 1.50482404E8 -1.91E7 -0.5 1.53032436E8 -2.56E7 -0.72 -0.8628 -0.984 3213556 Ald1-H_001486 OC[C@@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N08 compound treatment 1.25648829E8 -4.39E7 -1.15 1.22142316E8 -5.65E7 -1.59 -1.938 -0.9873 3213557 Ald1-H_001487 OC[C@@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N09 mock treatment 1.45985403E8 -2.36E7 -0.62 1.54955609E8 -2.36E7 -0.67 -0.9077 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N10 mock treatment 1.41015787E8 -2.86E7 -0.75 1.49196323E8 -2.94E7 -0.83 -1.1145 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N11 compound treatment 1.25007781E8 -4.46E7 -1.17 1.62067971E8 -1.65E7 -0.47 -1.1543 -0.919 3213558 Ald1-H_001488 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N12 compound treatment 6.3754899E7 -1.06E8 -2.77 7.8243115E7 -1.0E8 -2.83 -3.9584 -0.9999 3213560 Ald1-H_001489 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N13 mock treatment 1.42989879E8 -2.66E7 -0.7 1.58276076E8 -2.03E7 -0.57 -0.897 -0.9953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N14 mock treatment 1.30521373E8 -3.9E7 -1.02 1.56591917E8 -2.2E7 -0.62 -1.1613 -0.9714 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N15 compound treatment 1.20873625E8 -4.87E7 -1.27 1.18638216E8 -6.0E7 -1.69 -2.0962 -0.9903 3213562 Ald1-H_001490 CCOc1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1OCC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N16 compound treatment 6.0112693E7 -1.09E8 -2.87 4.6700641E7 -1.32E8 -3.72 -4.6543 -0.9917 3213564 Ald1-H_001491 CCOc1cccc(/C=N/NC(=O)CCCCCCC(=O)NO)c1OCC 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N17 compound treatment 9.8340464E7 -7.12E7 -1.86 8.5031784E7 -9.36E7 -2.64 -3.1829 -0.9856 3213566 Ald1-H_001492 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(I)cc(I)c2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N18 compound treatment 9.2483886E7 -7.71E7 -2.02 9.0137649E7 -8.85E7 -2.49 -3.1896 -0.9945 3213568 Ald1-H_001493 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(I)cc(I)c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N19 compound treatment 1.47587649E8 -2.2E7 -0.58 1.60437877E8 -1.82E7 -0.51 -0.7688 -0.9983 3213570 Ald1-H_001494 CN(C)c1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N20 compound treatment 3.5128924E7 -1.34E8 -3.52 3.3061082E7 -1.46E8 -4.1 -5.3886 -0.9971 3213572 Ald1-H_001495 CN(C)c1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N21 compound treatment 1.59127864E8 -1.04E7 -0.27 1.44146862E8 -3.45E7 -0.97 -0.8798 -0.8722 3213574 Ald1-H_001496 CCn1c2ccccc2c3cc(/C=N/NC(=O)CCCCCCC(=O)Nc4ccccc4O)ccc13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N22 compound treatment 1.15583058E8 -5.4E7 -1.41 8.704455E7 -9.16E7 -2.58 -2.8237 -0.9598 3213576 Ald1-H_001497 CCn1c2ccccc2c3cc(/C=N/NC(=O)CCCCCCC(=O)NO)ccc13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N23 compound treatment 1.25792724E8 -4.38E7 -1.15 1.12324606E8 -6.63E7 -1.87 -2.131 -0.9725 3213578 Ald1-H_001498 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(c(F)c2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 N24 compound treatment 8.5684627E7 -8.39E7 -2.2 6.1117224E7 -1.17E8 -3.31 -3.8937 -0.9801 3213580 Ald1-H_001499 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(c(F)c1)c2ccccc2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O01 compound treatment 1.41281523E8 -2.83E7 -0.74 1.39585582E8 -3.9E7 -1.1 -1.301 -0.9815 3213582 Ald1-H_001500 OCCOc1ccccc1/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O02 compound treatment 1.84594887E8 1.5E7 0.39 1.80429456E8 1830000.0 0.05 0.3146 0.7928 3213584 Ald1-H_001501 OCCOc1ccccc1/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O03 compound treatment 6.2000972E7 -1.08E8 -2.82 5.3795689E7 -1.25E8 -3.52 -4.478 -0.9939 3213586 Ald1-H_001502 OCCOc1cccc(/C=N/NC(=O)CCCCCCC(=O)NO)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O04 compound treatment 1.67735191E8 -1830000.0 -0.05 1.68497438E8 -1.01E7 -0.28 -0.2353 -0.8147 3213588 Ald1-H_001503 OCCOc1cccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O05 compound treatment 4.0950191E7 -1.29E8 -3.37 4.3859636E7 -1.35E8 -3.8 -5.0656 -0.9982 3213590 Ald1-H_001504 OCCOc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O06 compound treatment 1.58700118E8 -1.09E7 -0.28 1.64204438E8 -1.44E7 -0.41 -0.4881 -0.9849 3213592 Ald1-H_001505 OCCOc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O07 compound treatment 3.4826973E7 -1.35E8 -3.53 3.3861611E7 -1.45E8 -4.08 -5.3782 -0.9974 3213594 Ald1-H_001506 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O08 compound treatment 1.35092263E8 -3.45E7 -0.9 1.29648087E8 -4.9E7 -1.38 -1.6136 -0.9788 3213596 Ald1-H_001507 COc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c(O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O09 compound treatment 3.4035746E7 -1.36E8 -3.55 3.196707E7 -1.47E8 -4.13 -5.4306 -0.9971 3213598 Ald1-H_001508 COc1ccc(O)c(/C=N/NC(=O)CCCCCCC(=O)NO)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O10 compound treatment 1.36909224E8 -3.27E7 -0.85 1.41227522E8 -3.74E7 -1.05 -1.3493 -0.9946 3213600 Ald1-H_001509 COc1ccc(O)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O11 mock treatment 1.37897948E8 -3.17E7 -0.83 1.48703642E8 -2.99E7 -0.84 -1.182 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O12 mock treatment 1.23180101E8 -4.64E7 -1.21 1.52509253E8 -2.61E7 -0.74 -1.3786 -0.9711 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O13 compound treatment 7.0605892E7 -9.9E7 -2.59 5.6316729E7 -1.22E8 -3.45 -4.2685 -0.9901 3213602 Ald1-H_001510 COc1cc(/C=C/C=N/NC(=O)CCCCCCC(=O)NO)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O14 compound treatment 1.34577358E8 -3.5E7 -0.92 1.60781022E8 -1.78E7 -0.5 -1.0028 -0.96 3213604 Ald1-H_001511 COc1cc(/C=C/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O15 compound treatment 3.3409777E7 -1.36E8 -3.56 3.2051143E7 -1.47E8 -4.13 -5.4405 -0.9973 3213606 Ald1-H_001512 Cc1ccc(O)c(/C=N/NC(=O)CCCCCCC(=O)NO)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O16 compound treatment 1.41929855E8 -2.76E7 -0.72 1.39901716E8 -3.87E7 -1.09 -1.2827 -0.9801 3213608 Ald1-H_001513 Cc1ccc(O)c(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O17 compound treatment 1.40652563E8 -2.89E7 -0.76 1.51952241E8 -2.67E7 -0.75 -1.0663 -1.0 3213610 Ald1-H_001514 OCc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O18 compound treatment 1.50736821E8 -1.88E7 -0.49 1.63691887E8 -1.49E7 -0.42 -0.6457 -0.9968 3213612 Ald1-H_001515 OCc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)o1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O19 compound treatment 9.6122763E7 -7.34E7 -1.92 7.8968746E7 -9.96E7 -2.81 -3.3448 -0.9829 3213614 Ald1-H_001516 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc2ccccc2c1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O20 compound treatment 1.05590286E8 -6.4E7 -1.67 9.7950777E7 -8.07E7 -2.27 -2.7913 -0.9887 3213616 Ald1-H_001517 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc3ccccc3c2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O21 compound treatment 4.2035016E7 -1.28E8 -3.34 3.7421374E7 -1.41E8 -3.98 -5.1739 -0.9962 3213618 Ald1-H_001518 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(o1)c2cccc(Cl)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O22 compound treatment 1.23470912E8 -4.61E7 -1.21 1.02269522E8 -7.63E7 -2.15 -2.3743 -0.9626 3213620 Ald1-H_001519 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(o2)c3cccc(Cl)c3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O23 compound treatment 1.57809951E8 -1.18E7 -0.31 1.50300022E8 -2.83E7 -0.8 -0.7816 -0.9142 3213622 Ald1-H_001520 ONC(=O)CCCCCCC(=O)N/N=C/c1cc(Br)c(O)c(Br)c1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 O24 compound treatment 1.9524418E8 2.57E7 0.67 2.03151464E8 2.45E7 0.69 0.9644 0.9999 3213624 Ald1-H_001521 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cc(Br)c(O)c(Br)c2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P01 compound treatment 2.1880133E8 4.92E7 1.29 2.27600533E8 4.9E7 1.38 1.8877 0.9994 3213626 Ald1-H_001522 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2ccc(o2)S(=O)(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P02 compound treatment 1.74899826E8 5330000.0 0.14 1.84114962E8 5510000.0 0.16 0.2085 0.9986 3213628 Ald1-H_001523 ONC(=O)CCCCCCC(=O)N/N=C/c1ccc(o1)S(=O)(=O)O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P03 compound treatment 1.86989428E8 1.74E7 0.46 1.81580468E8 2980000.0 0.08 0.3818 0.8233 3213630 Ald1-H_001524 Cn1cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)c3ccccc13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P04 compound treatment 3.5252665E7 -1.34E8 -3.52 3.3531378E7 -1.45E8 -4.09 -5.3769 -0.9972 3213632 Ald1-H_001525 Cn1cc(/C=N/NC(=O)CCCCCCC(=O)NO)c2ccccc12 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P05 compound treatment 1.62560361E8 -7010000.0 -0.18 1.56330723E8 -2.23E7 -0.63 -0.5735 -0.877 3213634 Ald1-H_001526 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/c2cn(Cc3ccccc3)c4ccccc24 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P06 compound treatment 6.8372766E7 -1.01E8 -2.65 5.6744749E7 -1.22E8 -3.43 -4.3013 -0.9918 3213636 Ald1-H_001527 ONC(=O)CCCCCCC(=O)N/N=C/c1cn(Cc2ccccc2)c3ccccc13 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P07 compound treatment 1.51823843E8 -1.77E7 -0.46 1.38358356E8 -4.02E7 -1.13 -1.1304 -0.9223 3213638 Ald1-H_001528 Oc1ccccc1NC(=O)CCCCCCC(=O)N/N=C/C2=CCCCC2 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P08 compound treatment 3.5637646E7 -1.34E8 -3.51 3.3639886E7 -1.45E8 -4.09 -5.3676 -0.9971 3213640 Ald1-H_001529 ONC(=O)CCCCCCC(=O)N/N=C/C1=CCCCC1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P09 compound treatment 1.69655941E8 89500.0 0.0 1.68284857E8 -1.03E7 -0.29 -0.204 -0.7014 3213642 Ald1-H_001530 OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc1ccccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P10 compound treatment 1.38503122E8 -3.11E7 -0.81 1.3253537E8 -4.61E7 -1.3 -1.493 -0.9746 3213643 Ald1-H_001531 OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P11 mock treatment 1.53461778E8 -1.61E7 -0.42 1.60296132E8 -1.83E7 -0.52 -0.6629 -0.995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P12 mock treatment 1.40807018E8 -2.88E7 -0.75 1.584478E8 -2.02E7 -0.57 -0.934 -0.9904 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P13 compound treatment 1.45189023E8 -2.44E7 -0.64 1.66414542E8 -1.22E7 -0.34 -0.6941 -0.9578 3213644 Ald1-H_001532 OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P14 compound treatment 1.19873586E8 -4.97E7 -1.3 1.29685908E8 -4.89E7 -1.38 -1.8946 -0.9996 3213646 Ald1-H_001533 OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P15 compound treatment 1.64601378E8 -4970000.0 -0.13 1.63711464E8 -1.49E7 -0.42 -0.3887 -0.8846 3213648 Ald1-H_001534 OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)[C@H](O)[C@@H](O)[C@H]1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P16 compound treatment 1.56378455E8 -1.32E7 -0.35 1.40624799E8 -3.8E7 -1.07 -1.0009 -0.89 3213650 Ald1-H_001535 OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)/C=N/NC(=O)CCCCCCC(=O)NO)[C@H](O)[C@@H](O)[C@H]1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P17 compound treatment 1.6112339E8 -8440000.0 -0.22 1.49618404E8 -2.9E7 -0.82 -0.7339 -0.8672 3213652 Ald1-H_001536 C/C(=N\NC(=O)CCCCCCC(=O)Nc1ccccc1O)/C[P+](c2ccccc2)(c3ccccc3)c4ccccc4 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P18 compound treatment 1.34199643E8 -3.54E7 -0.93 1.35247473E8 -4.34E7 -1.22 -1.5186 -0.9906 3213654 Ald1-H_001537 C/C(=N\NC(=O)CCCCCCC(=O)NO)/C[P+](c1ccccc1)(c2ccccc2)c3ccccc3 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P19 compound treatment 1.5236685E8 -1.72E7 -0.45 1.51168451E8 -2.74E7 -0.77 -0.8651 -0.9669 3213656 Ald1-H_001538 CN(C)CCCOc1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P20 compound treatment 7.2254443E7 -9.73E7 -2.55 5.5178375E7 -1.23E8 -3.48 -4.2607 -0.9883 3213658 Ald1-H_001539 CN(C)CCCOc1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P21 compound treatment 1.63955044E8 -5610000.0 -0.15 1.61615231E8 -1.7E7 -0.48 -0.4424 -0.8834 3213660 Ald1-H_001540 CCOc1cc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P22 compound treatment 1.2556209E8 -4.4E7 -1.15 1.00168811E8 -7.84E7 -2.21 -2.3774 -0.9539 3213662 Ald1-H_001541 CCOc1cc(/C=N/NC(=O)CCCCCCC(=O)NO)ccc1O 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P23 compound treatment 2.04739817E8 3.52E7 0.92 1.83838754E8 5230000.0 0.15 0.7554 0.8101 3213664 Ald1-H_001542 CN(CCO)c1ccc(/C=N/NC(=O)CCCCCCC(=O)Nc2ccccc2O)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.2146 P24 compound treatment 1.5652808E8 -1.3E7 -0.34 1.34818504E8 -4.38E7 -1.23 -1.1138 -0.87 3213666 Ald1-H_001543 CN(CCO)c1ccc(/C=N/NC(=O)CCCCCCC(=O)NO)cc1 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A01 mock treatment 2.32845379E8 6.58E7 1.72 2.13550814E8 6.15E7 1.73 2.4427 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A02 mock treatment 1.92790204E8 2.57E7 0.67 1.94598883E8 4.25E7 1.2 1.3236 0.9627 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A03 mock treatment 2.0816957E8 4.11E7 1.08 1.81893379E8 2.98E7 0.84 1.3551 0.9926 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A04 mock treatment 2.0467933E8 3.76E7 0.98 1.886438E8 3.66E7 1.03 1.425 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A05 mock treatment 1.89402166E8 2.23E7 0.58 1.6511828E8 1.31E7 0.37 0.6734 0.9752 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A06 mock treatment 1.85764962E8 1.87E7 0.49 1.70176668E8 1.81E7 0.51 0.7069 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A07 mock treatment 1.70243006E8 3160000.0 0.08 1.5698535E8 4930000.0 0.14 0.1567 0.9692 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A08 mock treatment 1.72045857E8 4960000.0 0.13 1.62283266E8 1.02E7 0.29 0.2957 0.9351 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A09 mock treatment 1.81437116E8 1.44E7 0.38 1.50033693E8 -2020000.0 -0.06 0.2254 0.5933 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A10 mock treatment 1.75143155E8 8060000.0 0.21 1.59566565E8 7510000.0 0.21 0.2989 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A11 mock treatment 1.66916591E8 -169000.0 0.0 1.43934725E8 -8120000.0 -0.23 -0.1649 -0.7207 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A12 mock treatment 1.61937125E8 -5150000.0 -0.13 1.38085511E8 -1.4E7 -0.39 -0.3736 -0.898 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A13 mock treatment 1.63065884E8 -4020000.0 -0.11 1.50453822E8 -1600000.0 -0.05 -0.1063 -0.9283 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A14 mock treatment 1.49206398E8 -1.79E7 -0.47 1.25328378E8 -2.67E7 -0.75 -0.8635 -0.9738 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A15 mock treatment 1.52352977E8 -1.47E7 -0.39 1.38087782E8 -1.4E7 -0.39 -0.551 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A16 mock treatment 1.66085576E8 -1000000.0 -0.03 1.58157777E8 6110000.0 0.17 0.1031 0.5927 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A17 mock treatment 1.63997191E8 -3090000.0 -0.08 1.48776293E8 -3280000.0 -0.09 -0.1224 -0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A18 mock treatment 1.70777605E8 3690000.0 0.1 1.58969319E8 6920000.0 0.19 0.2062 0.9476 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A19 mock treatment 1.66495383E8 -590000.0 -0.02 1.56633892E8 4580000.0 0.13 0.0804 0.6181 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A20 mock treatment 1.81728619E8 1.46E7 0.38 1.6031611E8 8260000.0 0.23 0.4357 0.9715 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A21 mock treatment 1.7526056E8 8170000.0 0.21 1.61348868E8 9300000.0 0.26 0.3366 0.995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A22 mock treatment 1.90635131E8 2.35E7 0.62 1.70595324E8 1.85E7 0.52 0.8054 0.9966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A23 mock treatment 1.99161151E8 3.21E7 0.84 1.80104076E8 2.81E7 0.79 1.1527 0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base A24 mock treatment 2.20680393E8 5.36E7 1.4 2.01406264E8 4.94E7 1.39 1.9755 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B01 mock treatment 2.28114796E8 6.1E7 1.6 2.13667447E8 6.16E7 1.74 2.3574 0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B02 mock treatment 1.24488639E8 -4.26E7 -1.12 1.45966285E8 -6090000.0 -0.17 -0.9097 -0.8064 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B03 mock treatment 1.64996484E8 -2090000.0 -0.05 1.50120432E8 -1930000.0 -0.05 -0.0772 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B04 mock treatment 1.76394186E8 9310000.0 0.24 1.48207008E8 -3850000.0 -0.11 0.0957 0.3588 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B05 mock treatment 1.7667297E8 9590000.0 0.25 1.56205723E8 4150000.0 0.12 0.2602 0.9397 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B06 mock treatment 1.26741822E8 -4.03E7 -1.06 1.22503881E8 -2.95E7 -0.83 -1.3356 -0.9931 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B07 mock treatment 1.60527949E8 -6560000.0 -0.17 1.45739632E8 -6310000.0 -0.18 -0.2472 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B08 mock treatment 1.56419604E8 -1.07E7 -0.28 1.35389992E8 -1.67E7 -0.47 -0.5294 -0.9692 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B09 mock treatment 1.27728548E8 -3.94E7 -1.03 1.2338204E8 -2.87E7 -0.81 -1.2998 -0.9928 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B10 mock treatment 1.47327264E8 -1.98E7 -0.52 1.31378297E8 -2.07E7 -0.58 -0.7777 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B11 mock treatment 1.44055017E8 -2.3E7 -0.6 1.17646617E8 -3.44E7 -0.97 -1.1119 -0.9739 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B12 mock treatment 1.45040571E8 -2.2E7 -0.58 1.25767356E8 -2.63E7 -0.74 -0.9318 -0.9924 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B13 mock treatment 1.29760486E8 -3.73E7 -0.98 1.08016851E8 -4.4E7 -1.24 -1.5684 -0.993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B14 mock treatment 1.34407959E8 -3.27E7 -0.86 1.0972111E8 -4.23E7 -1.19 -1.4484 -0.9867 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B15 mock treatment 1.33941247E8 -3.31E7 -0.87 1.23013871E8 -2.9E7 -0.82 -1.1921 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B16 mock treatment 1.37323233E8 -2.98E7 -0.78 1.18828132E8 -3.32E7 -0.94 -1.2129 -0.9958 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B17 mock treatment 1.44106018E8 -2.3E7 -0.6 1.27306587E8 -2.47E7 -0.7 -0.9184 -0.9973 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B18 mock treatment 1.50252911E8 -1.68E7 -0.44 1.31739578E8 -2.03E7 -0.57 -0.7163 -0.9916 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B19 mock treatment 1.54935682E8 -1.22E7 -0.32 1.36978503E8 -1.51E7 -0.42 -0.5253 -0.9898 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B20 mock treatment 1.66192918E8 -893000.0 -0.02 1.56033438E8 3980000.0 0.11 0.0628 0.548 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B21 mock treatment 1.62534773E8 -4550000.0 -0.12 1.44283951E8 -7770000.0 -0.22 -0.239 -0.9591 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B22 mock treatment 1.71704695E8 4620000.0 0.12 1.54599358E8 2550000.0 0.07 0.1363 0.969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B23 mock treatment 1.82500099E8 1.54E7 0.4 1.61587638E8 9540000.0 0.27 0.4753 0.9805 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base B24 mock treatment 2.09617749E8 4.25E7 1.11 1.90846167E8 3.88E7 1.09 1.5603 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C01 mock treatment 2.20852435E8 5.38E7 1.41 1.98003905E8 4.6E7 1.29 1.9109 0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C02 mock treatment 1.72912434E8 5830000.0 0.15 1.61379332E8 9330000.0 0.26 0.2937 0.9665 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C03 mock treatment 1.81186427E8 1.41E7 0.37 1.66406473E8 1.44E7 0.4 0.547 0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C04 mock treatment 1.82212396E8 1.51E7 0.4 1.5827812E8 6230000.0 0.18 0.4041 0.9329 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C05 mock treatment 1.65523063E8 -1560000.0 -0.04 1.51947281E8 -105000.0 0.0 -0.031 -0.7562 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C06 mock treatment 1.54991919E8 -1.21E7 -0.32 1.49510933E8 -2540000.0 -0.07 -0.2745 -0.8457 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C07 mock treatment 1.70224708E8 3140000.0 0.08 1.53154777E8 1100000.0 0.03 0.0801 0.9115 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C08 mock treatment 1.56018528E8 -1.11E7 -0.29 1.42649951E8 -9400000.0 -0.26 -0.3922 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C09 mock treatment 1.43565489E8 -2.35E7 -0.62 1.39102774E8 -1.29E7 -0.36 -0.6934 -0.9688 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C10 mock treatment 1.45966188E8 -2.11E7 -0.55 1.35568316E8 -1.65E7 -0.46 -0.7194 -0.9963 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C11 mock treatment 1.49554008E8 -1.75E7 -0.46 1.33713127E8 -1.83E7 -0.52 -0.6899 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C12 mock treatment 1.41012594E8 -2.61E7 -0.68 1.24746617E8 -2.73E7 -0.77 -1.0267 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C13 mock treatment 1.30420808E8 -3.67E7 -0.96 1.21759546E8 -3.03E7 -0.85 -1.2823 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C14 mock treatment 1.26250932E8 -4.08E7 -1.07 1.1819304E8 -3.39E7 -0.95 -1.4305 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C15 mock treatment 1.283342E8 -3.88E7 -1.01 1.22926729E8 -2.91E7 -0.82 -1.2977 -0.9945 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C16 mock treatment 1.36217664E8 -3.09E7 -0.81 1.28666543E8 -2.34E7 -0.66 -1.0374 -0.9949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C17 mock treatment 1.48506302E8 -1.86E7 -0.49 1.39157456E8 -1.29E7 -0.36 -0.6009 -0.9897 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C18 mock treatment 1.47258029E8 -1.98E7 -0.52 1.34808753E8 -1.72E7 -0.49 -0.7106 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C19 mock treatment 1.50480086E8 -1.66E7 -0.43 1.37273072E8 -1.48E7 -0.42 -0.6019 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C20 mock treatment 1.52994313E8 -1.41E7 -0.37 1.42518061E8 -9530000.0 -0.27 -0.4508 -0.9879 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C21 mock treatment 1.61762157E8 -5320000.0 -0.14 1.49796615E8 -2260000.0 -0.06 -0.1435 -0.9368 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C22 mock treatment 1.71849693E8 4760000.0 0.12 1.45773184E8 -6280000.0 -0.18 -0.0369 -0.1706 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C23 mock treatment 1.82578896E8 1.55E7 0.41 1.55204409E8 3150000.0 0.09 0.3496 0.842 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base C24 mock treatment 1.99977758E8 3.29E7 0.86 1.76548059E8 2.45E7 0.69 1.0969 0.994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D01 mock treatment 2.17331889E8 5.02E7 1.32 1.9038299E8 3.83E7 1.08 1.6938 0.9952 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D02 mock treatment 1.68514671E8 1430000.0 0.04 1.58322049E8 6270000.0 0.18 0.1514 0.8382 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D03 mock treatment 1.86057253E8 1.9E7 0.5 1.58925729E8 6870000.0 0.19 0.4881 0.9157 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D04 mock treatment 1.71076936E8 3990000.0 0.1 1.54642305E8 2590000.0 0.07 0.1255 0.9846 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D05 mock treatment 1.64573052E8 -2510000.0 -0.07 1.55352819E8 3300000.0 0.09 0.0193 0.1691 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D06 mock treatment 1.57426947E8 -9660000.0 -0.25 1.43175359E8 -8880000.0 -0.25 -0.3557 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D07 mock treatment 1.62280292E8 -4810000.0 -0.13 1.47055635E8 -5000000.0 -0.14 -0.1885 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D08 mock treatment 1.5911573E8 -7970000.0 -0.21 1.37443588E8 -1.46E7 -0.41 -0.4386 -0.9504 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D09 mock treatment 1.51958504E8 -1.51E7 -0.4 1.34268298E8 -1.78E7 -0.5 -0.6344 -0.9932 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D10 mock treatment 1.47583984E8 -1.95E7 -0.51 1.30237795E8 -2.18E7 -0.61 -0.7957 -0.9957 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D11 mock treatment 1.44620741E8 -2.25E7 -0.59 1.23252728E8 -2.88E7 -0.81 -0.9897 -0.9875 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D12 mock treatment 1.41475489E8 -2.56E7 -0.67 1.23332904E8 -2.87E7 -0.81 -1.0463 -0.9956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D13 mock treatment 1.38165529E8 -2.89E7 -0.76 1.21567325E8 -3.05E7 -0.86 -1.1428 -0.998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D14 mock treatment 1.28822192E8 -3.83E7 -1.0 1.19036099E8 -3.3E7 -0.93 -1.3661 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D15 mock treatment 1.34709048E8 -3.24E7 -0.85 1.29941297E8 -2.21E7 -0.62 -1.0399 -0.9886 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D16 mock treatment 1.4160785E8 -2.55E7 -0.67 1.35568805E8 -1.65E7 -0.46 -0.8 -0.9844 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D17 mock treatment 1.41749873E8 -2.53E7 -0.66 1.35602719E8 -1.64E7 -0.46 -0.7967 -0.9847 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D18 mock treatment 1.49552866E8 -1.75E7 -0.46 1.38269997E8 -1.38E7 -0.39 -0.5992 -0.9966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D19 mock treatment 1.56217552E8 -1.09E7 -0.28 1.45483026E8 -6570000.0 -0.19 -0.3321 -0.9783 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D20 mock treatment 1.61185653E8 -5900000.0 -0.15 1.47111479E8 -4940000.0 -0.14 -0.2077 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D21 mock treatment 1.62488877E8 -4600000.0 -0.12 1.48586491E8 -3470000.0 -0.1 -0.1541 -0.9946 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D22 mock treatment 1.67397803E8 312000.0 0.01 1.4893929E8 -3110000.0 -0.09 -0.0563 -0.6385 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D23 mock treatment 1.75270847E8 8190000.0 0.21 1.50622936E8 -1430000.0 -0.04 0.123 0.5643 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base D24 mock treatment 1.98883736E8 3.18E7 0.83 1.87611694E8 3.56E7 1.0 1.2972 0.9957 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E01 mock treatment 2.17534723E8 5.04E7 1.32 1.93073242E8 4.1E7 1.16 1.7512 0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E02 mock treatment 1.87568018E8 2.05E7 0.54 1.80294292E8 2.82E7 0.8 0.9419 0.9815 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E03 mock treatment 1.97380855E8 3.03E7 0.79 1.80208719E8 2.82E7 0.79 1.1218 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E04 mock treatment 1.74977459E8 7890000.0 0.21 1.6353662E8 1.15E7 0.32 0.3749 0.9765 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E05 mock treatment 1.66487601E8 -598000.0 -0.02 1.52906336E8 854000.0 0.02 0.0059 0.2071 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E06 mock treatment 1.6174413E8 -5340000.0 -0.14 1.50609701E8 -1440000.0 -0.04 -0.1276 -0.8764 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E07 mock treatment 1.68143399E8 1060000.0 0.03 1.50977393E8 -1070000.0 -0.03 -0.0018 -0.0449 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E08 mock treatment 1.64891052E8 -2190000.0 -0.06 1.48134554E8 -3920000.0 -0.11 -0.1187 -0.9537 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E09 mock treatment 1.5368041E8 -1.34E7 -0.35 1.39540951E8 -1.25E7 -0.35 -0.4974 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E10 mock treatment 1.55466849E8 -1.16E7 -0.3 1.35530316E8 -1.65E7 -0.47 -0.5443 -0.9787 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E11 mock treatment 1.43964089E8 -2.31E7 -0.61 1.21128264E8 -3.09E7 -0.87 -1.0442 -0.9841 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E12 mock treatment 1.43759559E8 -2.33E7 -0.61 1.28462104E8 -2.36E7 -0.66 -0.9018 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E13 mock treatment 1.35422899E8 -3.17E7 -0.83 1.21812206E8 -3.02E7 -0.85 -1.1887 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E14 mock treatment 1.36293909E8 -3.08E7 -0.81 1.2824696E8 -2.38E7 -0.67 -1.0443 -0.9958 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E15 mock treatment 1.29790822E8 -3.73E7 -0.98 1.2841928E8 -2.36E7 -0.67 -1.1612 -0.9826 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E16 mock treatment 1.42557502E8 -2.45E7 -0.64 1.32717021E8 -1.93E7 -0.54 -0.8393 -0.9967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E17 mock treatment 1.47257106E8 -1.98E7 -0.52 1.3846149E8 -1.36E7 -0.38 -0.6378 -0.9888 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E18 mock treatment 1.57585458E8 -9500000.0 -0.25 1.42611168E8 -9440000.0 -0.27 -0.364 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E19 mock treatment 1.55669018E8 -1.14E7 -0.3 1.47052863E8 -5000000.0 -0.14 -0.3109 -0.9411 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E20 mock treatment 1.61301238E8 -5780000.0 -0.15 1.47213307E8 -4840000.0 -0.14 -0.2035 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E21 mock treatment 1.66131414E8 -954000.0 -0.02 1.52530431E8 478000.0 0.01 -0.0081 -0.2866 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E22 mock treatment 1.74664668E8 7580000.0 0.2 1.64315692E8 1.23E7 0.35 0.3847 0.9653 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E23 mock treatment 1.81470917E8 1.44E7 0.38 1.56862705E8 4810000.0 0.14 0.3621 0.9048 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base E24 mock treatment 2.02134186E8 3.5E7 0.92 1.76156928E8 2.41E7 0.68 1.1291 0.9891 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F01 mock treatment 2.15104316E8 4.8E7 1.26 1.91524979E8 3.95E7 1.11 1.6754 0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F02 mock treatment 1.98039592E8 3.1E7 0.81 1.83075574E8 3.1E7 0.87 1.1911 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F03 mock treatment 1.86449033E8 1.94E7 0.51 1.69675317E8 1.76E7 0.5 0.7096 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F04 mock treatment 1.72809662E8 5720000.0 0.15 1.57509379E8 5460000.0 0.15 0.2147 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F05 mock treatment 1.70070691E8 2980000.0 0.08 1.49072135E8 -2980000.0 -0.08 -0.0041 -0.036 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F06 mock treatment 1.62076231E8 -5010000.0 -0.13 1.46280559E8 -5770000.0 -0.16 -0.2077 -0.9943 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F07 mock treatment 1.70500137E8 3410000.0 0.09 1.53072855E8 1020000.0 0.03 0.0835 0.8897 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F08 mock treatment 1.60716124E8 -6370000.0 -0.17 1.40644983E8 -1.14E7 -0.32 -0.3452 -0.9533 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F09 mock treatment 1.60312047E8 -6770000.0 -0.18 1.43428003E8 -8620000.0 -0.24 -0.2972 -0.988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F10 mock treatment 1.4670276E8 -2.04E7 -0.53 1.29465905E8 -2.26E7 -0.64 -0.8274 -0.9962 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F11 mock treatment 1.47690958E8 -1.94E7 -0.51 1.26934862E8 -2.51E7 -0.71 -0.8595 -0.9867 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F12 mock treatment 1.36663209E8 -3.04E7 -0.8 1.15016899E8 -3.7E7 -1.04 -1.3011 -0.9911 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F13 mock treatment 1.39279377E8 -2.78E7 -0.73 1.21247417E8 -3.08E7 -0.87 -1.1285 -0.9962 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F14 mock treatment 1.35338787E8 -3.17E7 -0.83 1.27617205E8 -2.44E7 -0.69 -1.0745 -0.9956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F15 mock treatment 1.37673878E8 -2.94E7 -0.77 1.29353193E8 -2.27E7 -0.64 -0.9967 -0.9958 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F16 mock treatment 1.37878547E8 -2.92E7 -0.76 1.33702958E8 -1.83E7 -0.52 -0.9063 -0.9819 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F17 mock treatment 1.45800005E8 -2.13E7 -0.56 1.37471257E8 -1.46E7 -0.41 -0.6845 -0.9888 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F18 mock treatment 1.53929239E8 -1.32E7 -0.34 1.41658543E8 -1.04E7 -0.29 -0.4506 -0.9968 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F19 mock treatment 1.58713408E8 -8370000.0 -0.22 1.49172752E8 -2880000.0 -0.08 -0.2123 -0.9086 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F20 mock treatment 1.62643529E8 -4440000.0 -0.12 1.56188079E8 4140000.0 0.12 2.0E-4 0.0011 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F21 mock treatment 1.61635766E8 -5450000.0 -0.14 1.43262898E8 -8790000.0 -0.25 -0.276 -0.9657 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F22 mock treatment 1.67774416E8 689000.0 0.02 1.44525829E8 -7530000.0 -0.21 -0.1372 -0.6447 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F23 mock treatment 1.79464676E8 1.24E7 0.32 1.59058967E8 7010000.0 0.2 0.3688 0.9718 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base F24 mock treatment 2.05538201E8 3.85E7 1.01 2.02046263E8 5.0E7 1.41 1.708 0.9864 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G01 mock treatment 2.19745654E8 5.27E7 1.38 1.91169704E8 3.91E7 1.1 1.7542 0.9939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G02 mock treatment 1.92625192E8 2.55E7 0.67 1.72755981E8 2.07E7 0.58 0.8853 0.9977 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G03 mock treatment 1.93058175E8 2.6E7 0.68 1.7000844E8 1.8E7 0.51 0.8385 0.9894 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G04 mock treatment 1.87655231E8 2.06E7 0.54 1.64692113E8 1.26E7 0.36 0.6326 0.9799 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G05 mock treatment 1.75010636E8 7920000.0 0.21 1.58925438E8 6870000.0 0.19 0.2836 0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G06 mock treatment 1.77148815E8 1.01E7 0.26 1.49536814E8 -2520000.0 -0.07 0.1361 0.4991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G07 mock treatment 1.70739278E8 3650000.0 0.1 1.5257951E8 527000.0 0.01 0.0781 0.8073 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G08 mock treatment 1.65559418E8 -1530000.0 -0.04 1.48182606E8 -3870000.0 -0.11 -0.1054 -0.9072 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G09 mock treatment 1.59814353E8 -7270000.0 -0.19 1.41285539E8 -1.08E7 -0.3 -0.3491 -0.9748 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G10 mock treatment 1.56274218E8 -1.08E7 -0.28 1.4403271E8 -8020000.0 -0.23 -0.3599 -0.9938 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G11 mock treatment 1.45727047E8 -2.14E7 -0.56 1.25500578E8 -2.66E7 -0.75 -0.9244 -0.9897 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G12 mock treatment 1.45364982E8 -2.17E7 -0.57 1.2674447E8 -2.53E7 -0.71 -0.9063 -0.9937 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G13 mock treatment 1.43547599E8 -2.35E7 -0.62 1.32320606E8 -1.97E7 -0.56 -0.8289 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G14 mock treatment 1.41768563E8 -2.53E7 -0.66 1.28497134E8 -2.36E7 -0.66 -0.938 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G15 mock treatment 1.45686809E8 -2.14E7 -0.56 1.34035699E8 -1.8E7 -0.51 -0.7551 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G16 mock treatment 1.47325373E8 -1.98E7 -0.52 1.36456643E8 -1.56E7 -0.44 -0.6765 -0.9967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G17 mock treatment 1.51374049E8 -1.57E7 -0.41 1.43554929E8 -8500000.0 -0.24 -0.4601 -0.9669 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G18 mock treatment 1.53954607E8 -1.31E7 -0.34 1.41721939E8 -1.03E7 -0.29 -0.4489 -0.9966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G19 mock treatment 1.59201175E8 -7880000.0 -0.21 1.53512548E8 1460000.0 0.04 -0.1168 -0.5552 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G20 mock treatment 1.66683504E8 -402000.0 -0.01 1.57735106E8 5680000.0 0.16 0.1058 0.6592 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G21 mock treatment 1.67342688E8 257000.0 0.01 1.58157948E8 6110000.0 0.17 0.1264 0.7342 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G22 mock treatment 1.75137736E8 8050000.0 0.21 1.66918719E8 1.49E7 0.42 0.4453 0.9495 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G23 mock treatment 1.78967954E8 1.19E7 0.31 1.62078612E8 1.0E7 0.28 0.4197 0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base G24 mock treatment 2.03180775E8 3.61E7 0.94 1.88158962E8 3.61E7 1.02 1.3876 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H01 mock treatment 2.19489259E8 5.24E7 1.37 1.86850877E8 3.48E7 0.98 1.6634 0.9865 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H02 mock treatment 1.94903158E8 2.78E7 0.73 1.66690362E8 1.46E7 0.41 0.8066 0.9638 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H03 mock treatment 1.85864248E8 1.88E7 0.49 1.69351919E8 1.73E7 0.49 0.6923 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H04 mock treatment 1.81101097E8 1.4E7 0.37 1.58550469E8 6500000.0 0.18 0.3889 0.9485 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H05 mock treatment 1.6289391E8 -4190000.0 -0.11 5.458838E7 -9.75E7 -2.75 -2.0197 -0.7348 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H06 mock treatment 1.71314573E8 4230000.0 0.11 1.49597385E8 -2450000.0 -0.07 0.0294 0.2249 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H07 mock treatment 1.72636961E8 5550000.0 0.15 1.43991968E8 -8060000.0 -0.23 -0.0579 -0.2146 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H08 mock treatment 1.60429043E8 -6660000.0 -0.17 1.37217547E8 -1.48E7 -0.42 -0.4188 -0.9247 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H09 mock treatment 1.64682184E8 -2400000.0 -0.06 1.37462693E8 -1.46E7 -0.41 -0.3352 -0.8059 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H10 mock treatment 1.60174983E8 -6910000.0 -0.18 1.37207131E8 -1.48E7 -0.42 -0.4237 -0.9297 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H11 mock treatment 1.48595858E8 -1.85E7 -0.48 1.22574643E8 -2.95E7 -0.83 -0.9296 -0.9669 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H12 mock treatment 1.48124506E8 -1.9E7 -0.5 1.23666913E8 -2.84E7 -0.8 -0.9166 -0.9737 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H13 mock treatment 1.41572171E8 -2.55E7 -0.67 1.24274676E8 -2.78E7 -0.78 -1.0258 -0.9969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H14 mock treatment 1.43756349E8 -2.33E7 -0.61 1.39185392E8 -1.29E7 -0.36 -0.6882 -0.969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H15 mock treatment 1.46155641E8 -2.09E7 -0.55 1.32206539E8 -1.98E7 -0.56 -0.7829 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H16 mock treatment 1.53465866E8 -1.36E7 -0.36 1.37293404E8 -1.48E7 -0.42 -0.5462 -0.9971 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H17 mock treatment 1.52871151E8 -1.42E7 -0.37 1.48183082E8 -3870000.0 -0.11 -0.3402 -0.8774 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H18 mock treatment 1.55077181E8 -1.2E7 -0.31 1.43712347E8 -8340000.0 -0.24 -0.3885 -0.9897 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H19 mock treatment 1.58588715E8 -8500000.0 -0.22 1.4629526E8 -5760000.0 -0.16 -0.272 -0.988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H20 mock treatment 1.65809962E8 -1280000.0 -0.03 1.49529157E8 -2520000.0 -0.07 -0.0739 -0.9406 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H21 mock treatment 1.72073969E8 4990000.0 0.13 1.56345931E8 4290000.0 0.12 0.1779 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H22 mock treatment 1.76811237E8 9730000.0 0.25 1.6038025E8 8330000.0 0.23 0.346 0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H23 mock treatment 1.88966243E8 2.19E7 0.57 1.74110649E8 2.21E7 0.62 0.8446 0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base H24 mock treatment 2.09444976E8 4.24E7 1.11 1.78944169E8 2.69E7 0.76 1.3199 0.9828 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I01 mock treatment 2.24532942E8 5.74E7 1.5 1.93658793E8 4.16E7 1.17 1.8924 0.9924 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I02 mock treatment 1.99502544E8 3.24E7 0.85 1.71401909E8 1.93E7 0.55 0.9856 0.9771 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I03 mock treatment 1.85749393E8 1.87E7 0.49 1.68121279E8 1.61E7 0.45 0.6657 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I04 mock treatment 1.81589699E8 1.45E7 0.38 1.65757412E8 1.37E7 0.39 0.5416 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I05 mock treatment 1.69078954E8 1990000.0 0.05 1.48534254E8 -3520000.0 -0.1 -0.0332 -0.2964 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I06 mock treatment 1.65387139E8 -1700000.0 -0.04 1.50986383E8 -1070000.0 -0.03 -0.0527 -0.9818 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I07 mock treatment 1.71324671E8 4240000.0 0.11 1.50212761E8 -1840000.0 -0.05 0.0418 0.3414 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I08 mock treatment 1.60685155E8 -6400000.0 -0.17 1.40170101E8 -1.19E7 -0.33 -0.3552 -0.9488 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I09 mock treatment 1.65847375E8 -1240000.0 -0.03 1.44000297E8 -8050000.0 -0.23 -0.1834 -0.8 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I10 mock treatment 1.59698142E8 -7390000.0 -0.19 1.30610416E8 -2.14E7 -0.6 -0.564 -0.889 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I11 mock treatment 1.55973939E8 -1.11E7 -0.29 1.43011615E8 -9040000.0 -0.25 -0.3858 -0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I12 mock treatment 1.53269459E8 -1.38E7 -0.36 1.39139481E8 -1.29E7 -0.36 -0.513 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I13 mock treatment 1.48334493E8 -1.88E7 -0.49 1.21277277E8 -3.08E7 -0.87 -0.9603 -0.9637 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I14 mock treatment 1.49685818E8 -1.74E7 -0.46 1.41599397E8 -1.05E7 -0.29 -0.5304 -0.9778 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I15 mock treatment 1.52303229E8 -1.48E7 -0.39 1.45048403E8 -7000000.0 -0.2 -0.4132 -0.9512 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I16 mock treatment 1.51667946E8 -1.54E7 -0.4 1.43963771E8 -8090000.0 -0.23 -0.4466 -0.9634 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I17 mock treatment 1.48700368E8 -1.84E7 -0.48 1.44427574E8 -7620000.0 -0.21 -0.4922 -0.9339 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I18 mock treatment 1.53054696E8 -1.4E7 -0.37 1.39772915E8 -1.23E7 -0.35 -0.5044 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I19 mock treatment 1.57089118E8 -1.0E7 -0.26 1.48003987E8 -4050000.0 -0.11 -0.2657 -0.9308 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I20 mock treatment 1.6315769E8 -3930000.0 -0.1 1.51796053E8 -256000.0 -0.01 -0.0778 -0.7549 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I21 mock treatment 1.6723612E8 150000.0 0.0 1.57984428E8 5930000.0 0.17 0.121 0.7236 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I22 mock treatment 1.7133669E8 4250000.0 0.11 1.59602737E8 7550000.0 0.21 0.2291 0.9543 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I23 mock treatment 1.84245876E8 1.72E7 0.45 1.66424501E8 1.44E7 0.41 0.604 0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base I24 mock treatment 2.09575142E8 4.25E7 1.11 1.93649971E8 4.16E7 1.17 1.6154 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J01 mock treatment 2.19011466E8 5.19E7 1.36 1.91687709E8 3.96E7 1.12 1.7509 0.9952 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J02 mock treatment 1.92283757E8 2.52E7 0.66 1.65326144E8 1.33E7 0.37 0.7309 0.9639 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J03 mock treatment 1.79482361E8 1.24E7 0.32 1.68251283E8 1.62E7 0.46 0.5522 0.986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J04 mock treatment 1.69371314E8 2290000.0 0.06 1.52656146E8 604000.0 0.02 0.0543 0.8736 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J05 mock treatment 1.62689237E8 -4400000.0 -0.12 1.51374765E8 -677000.0 -0.02 -0.0949 -0.8133 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J06 mock treatment 1.6325191E8 -3830000.0 -0.1 1.44894935E8 -7160000.0 -0.2 -0.2136 -0.9481 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J07 mock treatment 1.64330735E8 -2760000.0 -0.07 1.45157186E8 -6900000.0 -0.19 -0.1884 -0.909 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J08 mock treatment 1.65638969E8 -1450000.0 -0.04 1.42515396E8 -9540000.0 -0.27 -0.2168 -0.7989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J09 mock treatment 1.63397548E8 -3690000.0 -0.1 1.4221359E8 -9840000.0 -0.28 -0.2643 -0.9003 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J10 mock treatment 1.59589686E8 -7500000.0 -0.2 1.31082859E8 -2.1E7 -0.59 -0.5566 -0.8939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J11 mock treatment 1.58080127E8 -9010000.0 -0.24 1.42278935E8 -9770000.0 -0.28 -0.3614 -0.997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J12 mock treatment 1.49304275E8 -1.78E7 -0.47 1.23337988E8 -2.87E7 -0.81 -0.9013 -0.9655 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J13 mock treatment 1.49513211E8 -1.76E7 -0.46 1.28038754E8 -2.4E7 -0.68 -0.8038 -0.9823 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J14 mock treatment 1.52722112E8 -1.44E7 -0.38 1.3661353E8 -1.54E7 -0.44 -0.5735 -0.9974 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J15 mock treatment 1.53394198E8 -1.37E7 -0.36 1.39728261E8 -1.23E7 -0.35 -0.499 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J16 mock treatment 1.5127811E8 -1.58E7 -0.41 1.41368465E8 -1.07E7 -0.3 -0.5055 -0.9878 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J17 mock treatment 1.58020173E8 -9070000.0 -0.24 1.46613921E8 -5440000.0 -0.15 -0.2762 -0.9776 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J18 mock treatment 1.56076591E8 -1.1E7 -0.29 1.41502286E8 -1.05E7 -0.3 -0.414 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J19 mock treatment 1.63513377E8 -3570000.0 -0.09 1.44753268E8 -7300000.0 -0.21 -0.2116 -0.9364 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J20 mock treatment 1.66960039E8 -126000.0 0.0 1.57626854E8 5570000.0 0.16 0.1088 0.6921 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J21 mock treatment 1.71275133E8 4190000.0 0.11 1.5661618E8 4560000.0 0.13 0.1685 0.9969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J22 mock treatment 1.75796253E8 8710000.0 0.23 1.62754623E8 1.07E7 0.3 0.3745 0.9905 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J23 mock treatment 1.87868423E8 2.08E7 0.54 1.80905047E8 2.89E7 0.81 0.9596 0.9809 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base J24 mock treatment 2.06404195E8 3.93E7 1.03 1.92711633E8 4.07E7 1.15 1.538 0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K01 mock treatment 2.27083083E8 6.0E7 1.57 1.95959585E8 4.39E7 1.24 1.9855 0.993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K02 mock treatment 1.9697242E8 2.99E7 0.78 1.80875988E8 2.88E7 0.81 1.1276 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K03 mock treatment 1.81827948E8 1.47E7 0.39 1.60122172E8 8070000.0 0.23 0.4337 0.9682 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K04 mock treatment 1.82440939E8 1.54E7 0.4 1.62016751E8 9960000.0 0.28 0.4828 0.9846 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K05 mock treatment 1.6197091E8 -5110000.0 -0.13 1.40856476E8 -1.12E7 -0.32 -0.3178 -0.9272 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K06 mock treatment 1.70435512E8 3350000.0 0.09 1.49092002E8 -2960000.0 -0.08 0.003 0.0249 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K07 mock treatment 1.61318709E8 -5770000.0 -0.15 1.43199104E8 -8850000.0 -0.25 -0.2832 -0.971 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K08 mock treatment 1.6343707E8 -3650000.0 -0.1 1.48921463E8 -3130000.0 -0.09 -0.1299 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K09 mock treatment 1.64402563E8 -2680000.0 -0.07 1.49705234E8 -2350000.0 -0.07 -0.0964 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K10 mock treatment 1.61266903E8 -5820000.0 -0.15 1.43212617E8 -8840000.0 -0.25 -0.2838 -0.9721 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K11 mock treatment 1.59263628E8 -7820000.0 -0.2 1.45220351E8 -6830000.0 -0.19 -0.2809 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K12 mock treatment 1.49556732E8 -1.75E7 -0.46 1.27491342E8 -2.46E7 -0.69 -0.8139 -0.9801 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K13 mock treatment 1.51896699E8 -1.52E7 -0.4 1.39761462E8 -1.23E7 -0.35 -0.5261 -0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K14 mock treatment 1.54768579E8 -1.23E7 -0.32 1.42720407E8 -9330000.0 -0.26 -0.4139 -0.9949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K15 mock treatment 1.522661E8 -1.48E7 -0.39 1.42007239E8 -1.0E7 -0.28 -0.4745 -0.988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K16 mock treatment 1.61265059E8 -5820000.0 -0.15 1.51612034E8 -440000.0 -0.01 -0.1165 -0.7622 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K17 mock treatment 1.56691728E8 -1.04E7 -0.27 1.46686112E8 -5370000.0 -0.15 -0.2993 -0.9616 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K18 mock treatment 1.57818937E8 -9270000.0 -0.24 1.44181158E8 -7870000.0 -0.22 -0.3284 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K19 mock treatment 1.61469975E8 -5620000.0 -0.15 1.46484677E8 -5570000.0 -0.16 -0.2149 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K20 mock treatment 1.65381169E8 -1700000.0 -0.04 1.6021834E8 8170000.0 0.23 0.1312 0.5596 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K21 mock treatment 1.67822355E8 737000.0 0.02 1.58700886E8 6650000.0 0.19 0.1461 0.7758 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K22 mock treatment 1.74051473E8 6970000.0 0.18 1.54756195E8 2700000.0 0.08 0.1828 0.9251 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K23 mock treatment 1.82432337E8 1.53E7 0.4 1.65827511E8 1.38E7 0.39 0.5586 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base K24 mock treatment 2.04018692E8 3.69E7 0.97 1.80770583E8 2.87E7 0.81 1.2559 0.9961 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L01 mock treatment 2.15626934E8 4.85E7 1.27 2.00696212E8 4.86E7 1.37 1.8678 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L02 mock treatment 1.92934968E8 2.58E7 0.68 1.6540705E8 1.34E7 0.38 0.7446 0.9617 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L03 mock treatment 1.89925214E8 2.28E7 0.6 1.75810583E8 2.38E7 0.67 0.8962 0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L04 mock treatment 1.65875649E8 -1210000.0 -0.03 1.47073488E8 -4980000.0 -0.14 -0.1216 -0.8455 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L05 mock treatment 1.76397823E8 9310000.0 0.24 1.57572352E8 5520000.0 0.16 0.2824 0.9765 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L06 mock treatment 1.6409813E8 -2990000.0 -0.08 1.52700401E8 648000.0 0.02 -0.0424 -0.5277 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L07 mock treatment 1.63200712E8 -3890000.0 -0.1 1.54770761E8 2720000.0 0.08 -0.0177 -0.1393 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L08 mock treatment 1.67874194E8 788000.0 0.02 1.45817055E8 -6240000.0 -0.18 -0.1097 -0.6198 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L09 mock treatment 1.63920658E8 -3170000.0 -0.08 1.47802391E8 -4250000.0 -0.12 -0.1433 -0.9838 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L10 mock treatment 1.60565137E8 -6520000.0 -0.17 1.47805172E8 -4250000.0 -0.12 -0.2053 -0.9849 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L11 mock treatment 1.59992499E8 -7090000.0 -0.19 1.34949453E8 -1.71E7 -0.48 -0.4721 -0.914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L12 mock treatment 1.50531734E8 -1.66E7 -0.43 1.3651937E8 -1.55E7 -0.44 -0.6159 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L13 mock treatment 1.54810595E8 -1.23E7 -0.32 1.28191681E8 -2.39E7 -0.67 -0.7027 -0.9429 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L14 mock treatment 1.5425988E8 -1.28E7 -0.34 1.41694437E8 -1.04E7 -0.29 -0.4438 -0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L15 mock treatment 1.53391071E8 -1.37E7 -0.36 1.35410369E8 -1.66E7 -0.47 -0.5851 -0.9912 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L16 mock treatment 1.57666202E8 -9420000.0 -0.25 1.39302022E8 -1.28E7 -0.36 -0.4284 -0.9831 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L17 mock treatment 1.5893412E8 -8150000.0 -0.21 1.51989989E8 -62200.0 0.0 -0.1521 -0.7129 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L18 mock treatment 1.56774379E8 -1.03E7 -0.27 1.46833346E8 -5220000.0 -0.15 -0.2949 -0.9592 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L19 mock treatment 1.6765488E8 569000.0 0.01 1.41788582E8 -1.03E7 -0.29 -0.194 -0.6698 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L20 mock treatment 1.63872714E8 -3210000.0 -0.08 1.59926672E8 7870000.0 0.22 0.0974 0.4106 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L21 mock treatment 1.68386461E8 1300000.0 0.03 1.47662597E8 -4390000.0 -0.12 -0.0634 -0.4941 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L22 mock treatment 1.71422753E8 4340000.0 0.11 1.49859368E8 -2190000.0 -0.06 0.0366 0.283 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L23 mock treatment 1.84960749E8 1.79E7 0.47 1.66539252E8 1.45E7 0.41 0.6195 0.9977 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base L24 mock treatment 2.06314301E8 3.92E7 1.03 1.83714087E8 3.17E7 0.89 1.357 0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M01 mock treatment 2.29691564E8 6.26E7 1.64 2.14974851E8 6.29E7 1.77 2.4127 0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M02 mock treatment 2.00357826E8 3.33E7 0.87 1.75477817E8 2.34E7 0.66 1.0827 0.9907 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M03 mock treatment 1.82561704E8 1.55E7 0.41 1.70567176E8 1.85E7 0.52 0.6554 0.9922 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M04 mock treatment 1.76211809E8 9130000.0 0.24 1.5716602E8 5110000.0 0.14 0.2708 0.9707 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M05 mock treatment 1.83165172E8 1.61E7 0.42 1.70418563E8 1.84E7 0.52 0.6636 0.9947 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M06 mock treatment 1.67010637E8 -75100.0 0.0 1.5076177E8 -1290000.0 -0.04 -0.0271 -0.7443 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M07 mock treatment 1.68496013E8 1410000.0 0.04 1.50790795E8 -1260000.0 -0.04 0.001 0.0189 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M08 mock treatment 1.72546297E8 5460000.0 0.14 1.59632899E8 7580000.0 0.21 0.2521 0.9809 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M09 mock treatment 1.66437911E8 -648000.0 -0.02 1.56185237E8 4130000.0 0.12 0.0704 0.5978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M10 mock treatment 1.68506634E8 1420000.0 0.04 1.52367117E8 315000.0 0.01 0.0326 0.8519 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M11 mock treatment 1.39715175E8 -2.74E7 -0.72 1.37357198E8 -1.47E7 -0.41 -0.7994 -0.966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M12 mock treatment 1.59920066E8 -7170000.0 -0.19 1.45097079E8 -6960000.0 -0.2 -0.2712 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M13 mock treatment 1.10728822E8 -5.64E7 -1.48 1.16022815E8 -3.6E7 -1.02 -1.7611 -0.9834 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M14 mock treatment 1.46841762E8 -2.02E7 -0.53 1.24292249E8 -2.78E7 -0.78 -0.9279 -0.982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M15 mock treatment 1.46087588E8 -2.1E7 -0.55 1.37638665E8 -1.44E7 -0.41 -0.6759 -0.9889 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M16 mock treatment 1.50466331E8 -1.66E7 -0.44 1.31436639E8 -2.06E7 -0.58 -0.7184 -0.9898 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M17 mock treatment 1.6370139E8 -3380000.0 -0.09 1.4143254E8 -1.06E7 -0.3 -0.2743 -0.8787 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M18 mock treatment 1.63430863E8 -3650000.0 -0.1 1.41849677E8 -1.02E7 -0.29 -0.271 -0.8942 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M19 mock treatment 1.6499417E8 -2090000.0 -0.05 1.50768109E8 -1280000.0 -0.04 -0.0643 -0.9798 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M20 mock treatment 1.66331327E8 -754000.0 -0.02 1.47832345E8 -4220000.0 -0.12 -0.0981 -0.8134 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M21 mock treatment 1.75852197E8 8770000.0 0.23 1.69589306E8 1.75E7 0.49 0.5117 0.9391 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M22 mock treatment 1.72495596E8 5410000.0 0.14 1.56597474E8 4550000.0 0.13 0.1907 0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M23 mock treatment 1.86416696E8 1.93E7 0.51 1.65528388E8 1.35E7 0.38 0.6263 0.99 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base M24 mock treatment 2.12027232E8 4.49E7 1.18 1.78854822E8 2.68E7 0.76 1.3659 0.9771 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N01 mock treatment 2.2650742E8 5.94E7 1.56 2.1095838E8 5.89E7 1.66 2.2737 0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N02 mock treatment 7.5318136E7 -9.18E7 -2.4 1.6195882E8 9910000.0 0.28 -1.5012 -0.6208 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N03 mock treatment 1.57695025E8 -9390000.0 -0.25 1.57165358E8 5110000.0 0.14 -0.0719 -0.2525 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N04 mock treatment 1.68816577E8 1730000.0 0.05 1.63404552E8 1.14E7 0.32 0.2582 0.7993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N05 mock treatment 1.71733057E8 4650000.0 0.12 1.49270413E8 -2780000.0 -0.08 0.0306 0.2114 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N06 mock treatment 1.68826041E8 1740000.0 0.05 1.54380231E8 2330000.0 0.07 0.0786 0.9841 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N07 mock treatment 1.65290756E8 -1800000.0 -0.05 1.49709537E8 -2340000.0 -0.07 -0.0799 -0.9861 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N08 mock treatment 1.66943617E8 -142000.0 0.0 1.46553949E8 -5500000.0 -0.15 -0.1122 -0.7239 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N09 mock treatment 1.65978215E8 -1110000.0 -0.03 1.48539347E8 -3510000.0 -0.1 -0.0905 -0.8773 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N10 mock treatment 1.60567834E8 -6520000.0 -0.17 1.46683947E8 -5370000.0 -0.15 -0.2276 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N11 mock treatment 1.69660034E8 2570000.0 0.07 1.49209737E8 -2840000.0 -0.08 -0.009 -0.0859 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N12 mock treatment 1.63286945E8 -3800000.0 -0.1 1.55211654E8 3160000.0 0.09 -0.0074 -0.0551 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N13 mock treatment 4.0787374E7 -1.26E8 -3.31 8.5765744E7 -6.63E7 -1.87 -3.6586 -0.9635 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N14 mock treatment 1.16547733E8 -5.05E7 -1.32 1.07227507E8 -4.48E7 -1.26 -1.8287 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N15 mock treatment 8.5997616E7 -8.11E7 -2.12 1.03557516E8 -4.85E7 -1.37 -2.4673 -0.9773 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N16 mock treatment 1.59390795E8 -7690000.0 -0.2 1.39687751E8 -1.24E7 -0.35 -0.3888 -0.9661 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N17 mock treatment 1.60406192E8 -6680000.0 -0.17 1.48172321E8 -3880000.0 -0.11 -0.201 -0.9744 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N18 mock treatment 1.69463779E8 2380000.0 0.06 1.45127409E8 -6920000.0 -0.2 -0.094 -0.4588 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N19 mock treatment 1.61205807E8 -5880000.0 -0.15 1.62705805E8 1.07E7 0.3 0.1035 0.3066 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N20 mock treatment 1.73344905E8 6260000.0 0.16 1.66803225E8 1.48E7 0.42 0.4098 0.9171 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N21 mock treatment 1.69103329E8 2020000.0 0.05 1.63587635E8 1.15E7 0.33 0.2672 0.8113 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N22 mock treatment 1.73121588E8 6040000.0 0.16 1.64193598E8 1.21E7 0.34 0.3537 0.9384 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N23 mock treatment 1.8541855E8 1.83E7 0.48 1.75235115E8 2.32E7 0.65 0.8013 0.9885 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base N24 mock treatment 2.11012415E8 4.39E7 1.15 1.87901967E8 3.58E7 1.01 1.5274 0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O01 mock treatment 2.33824328E8 6.67E7 1.75 2.23959837E8 7.19E7 2.03 2.6682 0.9973 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O02 mock treatment 2.06868195E8 3.98E7 1.04 1.95609719E8 4.36E7 1.23 1.6043 0.9967 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O03 mock treatment 1.94413779E8 2.73E7 0.72 1.82117889E8 3.01E7 0.85 1.1049 0.9965 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O04 mock treatment 1.85554508E8 1.85E7 0.48 1.75719145E8 2.37E7 0.67 0.8135 0.9875 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O05 mock treatment 1.78959133E8 1.19E7 0.31 1.6787574E8 1.58E7 0.45 0.5351 0.9844 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O06 mock treatment 1.85264865E8 1.82E7 0.48 1.68701886E8 1.66E7 0.47 0.6683 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O07 mock treatment 1.81665519E8 1.46E7 0.38 1.70510617E8 1.85E7 0.52 0.6377 0.9884 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O08 mock treatment 1.65624854E8 -1460000.0 -0.04 1.47544145E8 -4510000.0 -0.13 -0.1169 -0.8809 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O09 mock treatment 1.73671176E8 6590000.0 0.17 1.49639007E8 -2410000.0 -0.07 0.0738 0.3983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O10 mock treatment 1.64167515E8 -2920000.0 -0.08 1.50943806E8 -1110000.0 -0.03 -0.0761 -0.9221 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O11 mock treatment 1.59152442E8 -7930000.0 -0.21 1.54191126E8 2140000.0 0.06 -0.1042 -0.482 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O12 mock treatment 1.60462168E8 -6620000.0 -0.17 1.5612561E8 4070000.0 0.11 -0.0414 -0.1993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O13 mock treatment 1.5521702E8 -1.19E7 -0.31 1.4036062E8 -1.17E7 -0.33 -0.4527 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O14 mock treatment 1.63210077E8 -3880000.0 -0.1 1.56118353E8 4070000.0 0.11 0.0093 0.0607 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O15 mock treatment 1.60780342E8 -6310000.0 -0.17 1.53067015E8 1010000.0 0.03 -0.0965 -0.576 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O16 mock treatment 1.73775801E8 6690000.0 0.18 1.6431411E8 1.23E7 0.35 0.3682 0.9504 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O17 mock treatment 1.77662139E8 1.06E7 0.28 1.66761818E8 1.47E7 0.41 0.4889 0.9807 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O18 mock treatment 1.83203984E8 1.61E7 0.42 1.70149391E8 1.81E7 0.51 0.659 0.9956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O19 mock treatment 1.62094066E8 -4990000.0 -0.13 1.62626151E8 1.06E7 0.3 0.1183 0.3636 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O20 mock treatment 1.65342194E8 -1740000.0 -0.05 1.65991469E8 1.39E7 0.39 0.2455 0.6208 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O21 mock treatment 1.84146955E8 1.71E7 0.45 1.79016432E8 2.7E7 0.76 0.8531 0.9679 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O22 mock treatment 1.72257867E8 5170000.0 0.14 1.73107437E8 2.11E7 0.59 0.5153 0.8467 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O23 mock treatment 1.91717238E8 2.46E7 0.64 1.85973709E8 3.39E7 0.96 1.1319 0.9816 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base O24 mock treatment 2.15220421E8 4.81E7 1.26 2.06043576E8 5.4E7 1.52 1.9668 0.9956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P01 mock treatment 2.48988003E8 8.19E7 2.14 2.36883587E8 8.48E7 2.39 3.2064 0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P02 mock treatment 2.17575457E8 5.05E7 1.32 2.06249888E8 5.42E7 1.53 2.0145 0.9974 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P03 mock treatment 2.03112032E8 3.6E7 0.94 1.93045847E8 4.1E7 1.16 1.4837 0.9949 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P04 mock treatment 1.93151582E8 2.61E7 0.68 1.83019339E8 3.1E7 0.87 1.0995 0.9926 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P05 mock treatment 1.90688586E8 2.36E7 0.62 1.79860671E8 2.78E7 0.78 0.991 0.9931 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P06 mock treatment 1.8971833E8 2.26E7 0.59 1.77436898E8 2.54E7 0.72 0.9248 0.9956 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P07 mock treatment 1.90648677E8 2.36E7 0.62 1.81935923E8 2.99E7 0.84 1.0316 0.9883 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P08 mock treatment 1.92567883E8 2.55E7 0.67 1.80905221E8 2.89E7 0.81 1.0466 0.9952 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P09 mock treatment 1.78955145E8 1.19E7 0.31 1.69003697E8 1.7E7 0.48 0.5575 0.9783 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P10 mock treatment 1.80871377E8 1.38E7 0.36 1.66320094E8 1.43E7 0.4 0.5395 0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P11 mock treatment 1.79097102E8 1.2E7 0.31 1.69642926E8 1.76E7 0.5 0.5728 0.9759 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P12 mock treatment 1.80343378E8 1.33E7 0.35 1.67882349E8 1.58E7 0.45 0.5608 0.9923 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P13 mock treatment 1.80300495E8 1.32E7 0.35 1.69286052E8 1.72E7 0.49 0.588 0.9862 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P14 mock treatment 1.79138662E8 1.21E7 0.32 1.67494506E8 1.54E7 0.44 0.5308 0.9875 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P15 mock treatment 1.83216782E8 1.61E7 0.42 1.67562278E8 1.55E7 0.44 0.6076 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P16 mock treatment 1.81674135E8 1.46E7 0.38 1.69876535E8 1.78E7 0.5 0.6252 0.9909 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P17 mock treatment 1.88116812E8 2.1E7 0.55 1.70437564E8 1.84E7 0.52 0.7556 0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P18 mock treatment 1.96760953E8 2.97E7 0.78 1.75118668E8 2.31E7 0.65 1.0089 0.9961 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P19 mock treatment 1.97919982E8 3.08E7 0.81 1.77133404E8 2.51E7 0.71 1.0705 0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P20 mock treatment 1.65822339E8 -1260000.0 -0.03 1.76663869E8 2.46E7 0.69 0.467 0.6726 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P21 mock treatment 1.43674037E8 -2.34E7 -0.61 1.85992879E8 3.39E7 0.96 0.243 0.2139 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P22 mock treatment 1.64403357E8 -2680000.0 -0.07 1.9175664E8 3.97E7 1.12 0.7415 0.6614 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P23 mock treatment 1.86307495E8 1.92E7 0.5 2.03125945E8 5.11E7 1.44 1.3735 0.9008 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.Base P24 mock treatment 2.40367383E8 7.33E7 1.92 2.26772403E8 7.47E7 2.11 2.8453 0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A01 positive control 6.6295497E7 -8.45E7 -2.21 6.1990466E7 -8.61E7 -2.43 -3.2791 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A02 positive control 6.464965E7 -8.61E7 -2.25 5.6322075E7 -9.18E7 -2.59 -3.4225 -0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A03 positive control 6.609329E7 -8.47E7 -2.22 5.2411035E7 -9.57E7 -2.7 -3.4737 -0.9953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A04 positive control 6.7906624E7 -8.28E7 -2.17 6.3970412E7 -8.41E7 -2.37 -3.2098 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A05 positive control 5.2983658E7 -9.78E7 -2.56 4.9567504E7 -9.85E7 -2.78 -3.773 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A06 positive control 4.7595166E7 -1.03E8 -2.7 5.1774917E7 -9.63E7 -2.71 -3.8288 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A07 positive control 5.733878E7 -9.34E7 -2.45 5.0315781E7 -9.78E7 -2.76 -3.6775 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A08 positive control 5.3811955E7 -9.69E7 -2.54 5.2107615E7 -9.6E7 -2.71 -3.7071 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A09 positive control 4.7254052E7 -1.03E8 -2.71 5.1147709E7 -9.7E7 -2.73 -3.8476 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A10 positive control 4.7226156E7 -1.04E8 -2.71 5.047904E7 -9.76E7 -2.75 -3.8614 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A11 positive control 5.0165469E7 -1.01E8 -2.63 4.6596573E7 -1.02E8 -2.86 -3.8844 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A12 positive control 4.8240734E7 -1.03E8 -2.68 4.6598872E7 -1.01E8 -2.86 -3.92 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A13 mock treatment 1.34930037E8 -1.58E7 -0.41 1.46824582E8 -1270000.0 -0.04 -0.3182 -0.7655 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A14 mock treatment 1.39140075E8 -1.16E7 -0.3 1.30837556E8 -1.73E7 -0.49 -0.5589 -0.9744 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A15 mock treatment 1.42532983E8 -8220000.0 -0.22 1.38077584E8 -1.0E7 -0.28 -0.3518 -0.991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A16 mock treatment 1.51484372E8 733000.0 0.02 1.50328335E8 2230000.0 0.06 0.058 0.8828 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A17 mock treatment 1.45519433E8 -5230000.0 -0.14 1.4119406E8 -6900000.0 -0.19 -0.2344 -0.9852 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A18 mock treatment 1.610858E8 1.03E7 0.27 1.57249215E8 9150000.0 0.26 0.3736 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A19 mock treatment 1.50126512E8 -625000.0 -0.02 1.48165858E8 67400.0 0.0 -0.0102 -0.6208 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A20 mock treatment 1.63714352E8 1.3E7 0.34 1.50706223E8 2610000.0 0.07 0.2919 0.8408 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A21 mock treatment 1.58136577E8 7390000.0 0.19 1.48688259E8 590000.0 0.02 0.1485 0.7651 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A22 mock treatment 1.75018799E8 2.43E7 0.64 1.64424663E8 1.63E7 0.46 0.7745 0.9875 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A23 mock treatment 1.81345182E8 3.06E7 0.8 1.69514334E8 2.14E7 0.6 0.993 0.9903 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon A24 mock treatment 2.01395684E8 5.06E7 1.33 1.92778934E8 4.47E7 1.26 1.8277 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B01 positive control 7.3010952E7 -7.77E7 -2.03 6.6414449E7 -8.17E7 -2.3 -3.0666 -0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B02 positive control 5.3104463E7 -9.76E7 -2.56 4.721208E7 -1.01E8 -2.84 -3.8177 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B03 positive control 5.0808805E7 -9.99E7 -2.62 4.3726345E7 -1.04E8 -2.94 -3.9297 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B04 positive control 4.9224681E7 -1.02E8 -2.66 4.1566936E7 -1.07E8 -3.0 -4.002 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B05 positive control 4.8184463E7 -1.03E8 -2.68 5.2391125E7 -9.57E7 -2.7 -3.8056 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B06 positive control 4.8175808E7 -1.03E8 -2.69 4.0683921E7 -1.07E8 -3.03 -4.0391 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B07 positive control 5.0390523E7 -1.0E8 -2.63 5.0206082E7 -9.79E7 -2.76 -3.8083 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B08 positive control 4.6616671E7 -1.04E8 -2.73 4.026719E7 -1.08E8 -3.04 -4.0762 -0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B09 positive control 5.0280044E7 -1.0E8 -2.63 4.5121986E7 -1.03E8 -2.9 -3.9117 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B10 positive control 4.828511E7 -1.02E8 -2.68 4.016542E7 -1.08E8 -3.04 -4.0474 -0.998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B11 positive control 4.0102044E7 -1.11E8 -2.9 3.7966085E7 -1.1E8 -3.1 -4.2427 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B12 positive control 4.1935574E7 -1.09E8 -2.85 4.8288143E7 -9.98E7 -2.81 -4.003 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B13 mock treatment 1.23310027E8 -2.74E7 -0.72 1.14914556E8 -3.32E7 -0.94 -1.1692 -0.9915 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B14 mock treatment 1.25738168E8 -2.5E7 -0.65 1.20582013E8 -2.75E7 -0.78 -1.0113 -0.9965 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B15 mock treatment 1.37251751E8 -1.35E7 -0.35 1.33356708E8 -1.47E7 -0.42 -0.5436 -0.9968 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B16 mock treatment 1.33878765E8 -1.69E7 -0.44 1.17857911E8 -3.02E7 -0.85 -0.9149 -0.9532 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B17 mock treatment 1.35627595E8 -1.51E7 -0.4 1.25128135E8 -2.3E7 -0.65 -0.7377 -0.9722 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B18 mock treatment 1.35345189E8 -1.54E7 -0.4 1.30222623E8 -1.79E7 -0.5 -0.6414 -0.9939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B19 mock treatment 1.39320478E8 -1.14E7 -0.3 1.27732364E8 -2.04E7 -0.57 -0.6174 -0.9539 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B20 mock treatment 1.56065127E8 5310000.0 0.14 1.5140559E8 3310000.0 0.09 0.1643 0.981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B21 mock treatment 1.49878046E8 -873000.0 -0.02 1.36480959E8 -1.16E7 -0.33 -0.2477 -0.7546 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B22 mock treatment 1.55110691E8 4360000.0 0.11 1.42930259E8 -5170000.0 -0.15 -0.0223 -0.1205 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B23 mock treatment 1.67874274E8 1.71E7 0.45 1.55306709E8 7210000.0 0.2 0.4606 0.9359 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon B24 mock treatment 1.89727851E8 3.9E7 1.02 1.83362636E8 3.53E7 0.99 1.4241 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C01 positive control 6.1792767E7 -8.9E7 -2.33 4.757285E7 -1.01E8 -2.83 -3.6497 -0.9953 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C02 positive control 4.0337848E7 -1.1E8 -2.89 4.339906E7 -1.05E8 -2.95 -4.13 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C03 positive control 4.6799667E7 -1.04E8 -2.72 4.2978018E7 -1.05E8 -2.96 -4.0188 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C04 positive control 4.7344796E7 -1.03E8 -2.71 4.130201E7 -1.07E8 -3.01 -4.0421 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C05 positive control 4.9506208E7 -1.01E8 -2.65 4.1917829E7 -1.06E8 -2.99 -3.9898 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C06 positive control 5.1374658E7 -9.94E7 -2.6 4.5515651E7 -1.03E8 -2.89 -3.8836 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C07 positive control 5.2205695E7 -9.85E7 -2.58 5.1297242E7 -9.68E7 -2.73 -3.753 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C08 positive control 4.770255E7 -1.03E8 -2.7 3.9155716E7 -1.09E8 -3.07 -4.0783 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C09 positive control 5.4456506E7 -9.63E7 -2.52 4.7166403E7 -1.01E8 -2.84 -3.7936 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C10 positive control 4.9056629E7 -1.02E8 -2.66 4.4241219E7 -1.04E8 -2.93 -3.9519 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C11 positive control 4.427472E7 -1.06E8 -2.79 4.800674E7 -1.0E8 -2.82 -3.9653 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C12 positive control 4.8017004E7 -1.03E8 -2.69 4.6474096E7 -1.02E8 -2.86 -3.9266 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C13 mock treatment 1.24232089E8 -2.65E7 -0.69 1.35289759E8 -1.28E7 -0.36 -0.7461 -0.9536 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C14 mock treatment 1.31706604E8 -1.9E7 -0.5 1.28294946E8 -1.98E7 -0.56 -0.7471 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C15 mock treatment 1.42507495E8 -8240000.0 -0.22 1.33465936E8 -1.46E7 -0.41 -0.4442 -0.9544 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C16 mock treatment 1.3753348E8 -1.32E7 -0.35 1.32867581E8 -1.52E7 -0.43 -0.5482 -0.9943 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C17 mock treatment 1.45954663E8 -4800000.0 -0.13 1.43266653E8 -4830000.0 -0.14 -0.1851 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C18 mock treatment 1.41269512E8 -9480000.0 -0.25 1.42240559E8 -5860000.0 -0.17 -0.2922 -0.9804 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C19 mock treatment 1.36814906E8 -1.39E7 -0.36 1.40414987E8 -7680000.0 -0.22 -0.4111 -0.969 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C20 mock treatment 1.43511195E8 -7240000.0 -0.19 1.46698898E8 -1400000.0 -0.04 -0.1619 -0.8363 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C21 mock treatment 1.49419569E8 -1330000.0 -0.03 1.45318768E8 -2780000.0 -0.08 -0.08 -0.9335 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C22 mock treatment 1.55727196E8 4980000.0 0.13 1.42291261E8 -5810000.0 -0.16 -0.0236 -0.1129 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C23 mock treatment 1.54866582E8 4120000.0 0.11 1.52375504E8 4280000.0 0.12 0.1614 0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon C24 mock treatment 1.68006641E8 1.73E7 0.45 1.64961739E8 1.69E7 0.48 0.6554 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D01 positive control 5.440866E7 -9.63E7 -2.52 4.8487307E7 -9.96E7 -2.81 -3.7682 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D02 positive control 4.6466812E7 -1.04E8 -2.73 4.2276482E7 -1.06E8 -2.98 -4.039 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D03 positive control 4.796681E7 -1.03E8 -2.69 4.2245366E7 -1.06E8 -2.98 -4.0118 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D04 positive control 4.8623312E7 -1.02E8 -2.67 4.3893313E7 -1.04E8 -2.94 -3.9668 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D05 positive control 4.7347117E7 -1.03E8 -2.71 4.6575249E7 -1.02E8 -2.86 -3.937 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D06 positive control 4.6506425E7 -1.04E8 -2.73 4.7162833E7 -1.01E8 -2.84 -3.9408 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D07 positive control 4.6449212E7 -1.04E8 -2.73 4.3018217E7 -1.05E8 -2.96 -4.0245 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D08 positive control 4.4943352E7 -1.06E8 -2.77 4.5477979E7 -1.03E8 -2.89 -4.0034 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D09 positive control 4.7078955E7 -1.04E8 -2.71 4.2496298E7 -1.06E8 -2.98 -4.0232 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D10 positive control 4.5426061E7 -1.05E8 -2.76 4.4022909E7 -1.04E8 -2.93 -4.0234 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D11 positive control 3.8995886E7 -1.12E8 -2.93 4.2446035E7 -1.06E8 -2.98 -4.1739 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D12 positive control 4.7655692E7 -1.03E8 -2.7 4.6817106E7 -1.01E8 -2.85 -3.9265 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D13 mock treatment 1.32781976E8 -1.8E7 -0.47 1.35767948E8 -1.23E7 -0.35 -0.5783 -0.9889 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D14 mock treatment 1.32268303E8 -1.85E7 -0.48 1.34288562E8 -1.38E7 -0.39 -0.6173 -0.9942 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D15 mock treatment 1.35902133E8 -1.48E7 -0.39 1.34953523E8 -1.31E7 -0.37 -0.5368 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D16 mock treatment 1.41092614E8 -9660000.0 -0.25 1.3848779E8 -9610000.0 -0.27 -0.3703 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D17 mock treatment 1.40689702E8 -1.01E7 -0.26 1.38643936E8 -9450000.0 -0.27 -0.3746 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D18 mock treatment 1.39142721E8 -1.16E7 -0.3 1.35885902E8 -1.22E7 -0.34 -0.4582 -0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D19 mock treatment 1.47042675E8 -3710000.0 -0.1 1.43556681E8 -4540000.0 -0.13 -0.1591 -0.9907 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D20 mock treatment 1.43599802E8 -7150000.0 -0.19 1.44528599E8 -3570000.0 -0.1 -0.2035 -0.9576 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D21 mock treatment 1.43646484E8 -7100000.0 -0.19 1.44994736E8 -3100000.0 -0.09 -0.1934 -0.9408 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D22 mock treatment 1.49575543E8 -1180000.0 -0.03 1.45236579E8 -2860000.0 -0.08 -0.0788 -0.9127 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D23 mock treatment 1.59007824E8 8260000.0 0.22 1.54721011E8 6620000.0 0.19 0.2848 0.9973 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon D24 mock treatment 1.70277877E8 1.95E7 0.51 1.85743955E8 3.76E7 1.06 1.1116 0.9439 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E01 positive control 5.6192868E7 -9.46E7 -2.48 4.9476025E7 -9.86E7 -2.78 -3.7155 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E02 positive control 4.7961611E7 -1.03E8 -2.69 4.7474718E7 -1.01E8 -2.84 -3.9077 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E03 positive control 5.9730761E7 -9.1E7 -2.38 5.7369056E7 -9.07E7 -2.56 -3.4927 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E04 positive control 4.7133408E7 -1.04E8 -2.71 4.360704E7 -1.04E8 -2.94 -4.0001 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E05 positive control 4.5530897E7 -1.05E8 -2.75 4.3755729E7 -1.04E8 -2.94 -4.0268 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E06 positive control 5.0297062E7 -1.0E8 -2.63 4.6457014E7 -1.02E8 -2.86 -3.8847 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E07 positive control 4.6489996E7 -1.04E8 -2.73 4.1459175E7 -1.07E8 -3.01 -4.0548 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E08 positive control 4.7215932E7 -1.04E8 -2.71 4.5932104E7 -1.02E8 -2.88 -3.9522 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E09 positive control 4.7282559E7 -1.03E8 -2.71 4.2434012E7 -1.06E8 -2.98 -4.0207 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E10 positive control 4.7494147E7 -1.03E8 -2.7 4.5289782E7 -1.03E8 -2.9 -3.9599 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E11 positive control 4.4294579E7 -1.06E8 -2.79 4.7278789E7 -1.01E8 -2.84 -3.9795 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E12 positive control 4.9652912E7 -1.01E8 -2.65 4.8035856E7 -1.0E8 -2.82 -3.8652 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E13 mock treatment 1.31665726E8 -1.91E7 -0.5 1.35743764E8 -1.24E7 -0.35 -0.5995 -0.9844 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E14 mock treatment 1.36183835E8 -1.46E7 -0.38 1.3663626E8 -1.15E7 -0.32 -0.498 -0.9966 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E15 mock treatment 1.3944652E8 -1.13E7 -0.3 1.35009798E8 -1.31E7 -0.37 -0.4701 -0.994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E16 mock treatment 1.39042734E8 -1.17E7 -0.31 1.37937731E8 -1.02E7 -0.29 -0.4192 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E17 mock treatment 1.44256031E8 -6500000.0 -0.17 1.38827756E8 -9270000.0 -0.26 -0.305 -0.9784 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E18 mock treatment 1.42676152E8 -8080000.0 -0.21 1.4291139E8 -5190000.0 -0.15 -0.2528 -0.9838 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E19 mock treatment 1.51409271E8 658000.0 0.02 1.44658127E8 -3440000.0 -0.1 -0.0564 -0.5725 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E20 mock treatment 1.45283836E8 -5470000.0 -0.14 1.50703148E8 2600000.0 0.07 -0.0493 -0.3065 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E21 mock treatment 1.50522206E8 -229000.0 -0.01 1.41880325E8 -6220000.0 -0.18 -0.1281 -0.7309 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E22 mock treatment 1.65718126E8 1.5E7 0.39 1.62831929E8 1.47E7 0.42 0.5706 0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E23 mock treatment 1.62739499E8 1.2E7 0.31 1.54517369E8 6420000.0 0.18 0.3498 0.9657 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon E24 mock treatment 1.8504602E8 3.43E7 0.9 1.79672593E8 3.16E7 0.89 1.264 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F01 positive control 7.1552191E7 -7.92E7 -2.07 5.3238476E7 -9.49E7 -2.67 -3.3562 -0.9921 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F02 positive control 6.0418195E7 -9.03E7 -2.36 5.7048224E7 -9.11E7 -2.57 -3.4864 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F03 positive control 4.9899214E7 -1.01E8 -2.64 5.4078461E7 -9.4E7 -2.65 -3.7402 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F04 positive control 4.6553188E7 -1.04E8 -2.73 4.4608225E7 -1.03E8 -2.92 -3.9909 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F05 positive control 4.6246157E7 -1.05E8 -2.74 4.2386841E7 -1.06E8 -2.98 -4.0408 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F06 positive control 4.6276985E7 -1.04E8 -2.73 4.2911025E7 -1.05E8 -2.96 -4.0298 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F07 positive control 5.1264679E7 -9.95E7 -2.6 4.7222662E7 -1.01E8 -2.84 -3.8516 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F08 positive control 4.3946725E7 -1.07E8 -2.8 4.2525813E7 -1.06E8 -2.98 -4.0806 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F09 positive control 4.5627883E7 -1.05E8 -2.75 4.3573218E7 -1.05E8 -2.95 -4.0286 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F10 positive control 4.5388259E7 -1.05E8 -2.76 4.3034644E7 -1.05E8 -2.96 -4.0438 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F11 positive control 4.5318412E7 -1.05E8 -2.76 4.5166017E7 -1.03E8 -2.9 -4.0026 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F12 positive control 4.6074117E7 -1.05E8 -2.74 4.3590748E7 -1.05E8 -2.95 -4.02 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F13 mock treatment 1.32890447E8 -1.79E7 -0.47 1.33547754E8 -1.46E7 -0.41 -0.6205 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F14 mock treatment 1.31586487E8 -1.92E7 -0.5 1.34971644E8 -1.31E7 -0.37 -0.6163 -0.9888 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F15 mock treatment 1.38107757E8 -1.26E7 -0.33 1.33260592E8 -1.48E7 -0.42 -0.5297 -0.9933 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F16 mock treatment 1.38335839E8 -1.24E7 -0.32 1.33515167E8 -1.46E7 -0.41 -0.5204 -0.9932 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F17 mock treatment 1.42606072E8 -8150000.0 -0.21 1.40448959E8 -7650000.0 -0.22 -0.3032 -1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F18 mock treatment 1.41435628E8 -9320000.0 -0.24 1.38760212E8 -9340000.0 -0.26 -0.3585 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F19 mock treatment 1.47025314E8 -3730000.0 -0.1 1.44227175E8 -3870000.0 -0.11 -0.1461 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F20 mock treatment 1.52753493E8 2000000.0 0.05 1.48821144E8 723000.0 0.02 0.0515 0.9152 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F21 mock treatment 1.53449809E8 2700000.0 0.07 1.40126331E8 -7970000.0 -0.22 -0.1089 -0.4625 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F22 mock treatment 1.52694223E8 1940000.0 0.05 1.52831052E8 4730000.0 0.13 0.1303 0.9127 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F23 mock treatment 1.65375347E8 1.46E7 0.38 1.61172863E8 1.31E7 0.37 0.5312 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon F24 mock treatment 1.94882866E8 4.41E7 1.16 1.88129349E8 4.0E7 1.13 1.6145 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G01 positive control 5.3193078E7 -9.76E7 -2.55 4.7321011E7 -1.01E8 -2.84 -3.8139 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G02 positive control 4.8563877E7 -1.02E8 -2.67 4.7466863E7 -1.01E8 -2.84 -3.8967 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G03 positive control 4.8915886E7 -1.02E8 -2.67 4.2712262E7 -1.05E8 -2.97 -3.9849 -0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G04 positive control 4.6656848E7 -1.04E8 -2.72 4.736149E7 -1.01E8 -2.84 -3.9341 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G05 positive control 4.4854553E7 -1.06E8 -2.77 4.253556E7 -1.06E8 -2.97 -4.0636 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G06 positive control 4.5697304E7 -1.05E8 -2.75 4.1257149E7 -1.07E8 -3.01 -4.0735 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G07 positive control 4.3723004E7 -1.07E8 -2.8 4.1416031E7 -1.07E8 -3.01 -4.1069 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G08 positive control 4.7009084E7 -1.04E8 -2.72 4.4238936E7 -1.04E8 -2.93 -3.9898 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G09 positive control 4.5425954E7 -1.05E8 -2.76 4.2986149E7 -1.05E8 -2.96 -4.0441 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G10 positive control 4.7380953E7 -1.03E8 -2.71 4.6506154E7 -1.02E8 -2.86 -3.9377 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G11 positive control 4.3626919E7 -1.07E8 -2.8 4.286138E7 -1.05E8 -2.97 -4.0799 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G12 positive control 4.5170354E7 -1.06E8 -2.76 4.2968133E7 -1.05E8 -2.96 -4.0492 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G13 mock treatment 1.40117488E8 -1.06E7 -0.28 1.39270336E8 -8830000.0 -0.25 -0.3727 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G14 mock treatment 1.41849482E8 -8900000.0 -0.23 1.40034544E8 -8060000.0 -0.23 -0.3255 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G15 mock treatment 1.42003923E8 -8750000.0 -0.23 1.37057635E8 -1.1E7 -0.31 -0.3819 -0.9886 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G16 mock treatment 1.41419539E8 -9330000.0 -0.24 1.38013503E8 -1.01E7 -0.28 -0.3737 -0.9972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G17 mock treatment 1.51575349E8 824000.0 0.02 1.49281691E8 1180000.0 0.03 0.0388 0.9778 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G18 mock treatment 1.51918092E8 1170000.0 0.03 1.45099049E8 -3000000.0 -0.08 -0.0382 -0.4247 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G19 mock treatment 1.4778297E8 -2970000.0 -0.08 1.46600742E8 -1500000.0 -0.04 -0.0848 -0.9589 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G20 mock treatment 1.52344609E8 1590000.0 0.04 1.56627587E8 8530000.0 0.24 0.1994 0.8176 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G21 mock treatment 1.54035314E8 3280000.0 0.09 1.54987098E8 6890000.0 0.19 0.1981 0.9329 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G22 mock treatment 1.6789418E8 1.71E7 0.45 1.6970337E8 2.16E7 0.61 0.7478 0.9887 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G23 mock treatment 1.64984832E8 1.42E7 0.37 1.67626722E8 1.95E7 0.55 0.6526 0.982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon G24 mock treatment 1.88855529E8 3.81E7 1.0 1.78529038E8 3.04E7 0.86 1.3117 0.9972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H01 positive control 5.3160542E7 -9.76E7 -2.55 4.6791477E7 -1.01E8 -2.85 -3.8251 -0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H02 positive control 4.7115032E7 -1.04E8 -2.71 4.2739529E7 -1.05E8 -2.97 -4.0177 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H03 positive control 4.5692285E7 -1.05E8 -2.75 4.227038E7 -1.06E8 -2.98 -4.0534 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H04 positive control 4.8019234E7 -1.03E8 -2.69 3.9685152E7 -1.08E8 -3.06 -4.0619 -0.998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H05 positive control 4.6728243E7 -1.04E8 -2.72 4.0566154E7 -1.08E8 -3.03 -4.0682 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H06 positive control 4.4483054E7 -1.06E8 -2.78 4.3686391E7 -1.04E8 -2.94 -4.0476 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H07 positive control 4.3192076E7 -1.08E8 -2.82 4.1038389E7 -1.07E8 -3.02 -4.1242 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H08 positive control 4.3908087E7 -1.07E8 -2.8 4.3952089E7 -1.04E8 -2.93 -4.0529 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H09 positive control 4.8388783E7 -1.02E8 -2.68 4.6308204E7 -1.02E8 -2.87 -3.923 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H10 positive control 4.6991694E7 -1.04E8 -2.72 4.5496986E7 -1.03E8 -2.89 -3.9651 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H11 positive control 4.4478011E7 -1.06E8 -2.78 4.276909E7 -1.05E8 -2.97 -4.0659 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H12 positive control 4.4692445E7 -1.06E8 -2.78 4.2405138E7 -1.06E8 -2.98 -4.0692 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H13 mock treatment 1.35775899E8 -1.5E7 -0.39 1.27711802E8 -2.04E7 -0.57 -0.6834 -0.9826 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H14 mock treatment 1.39221497E8 -1.15E7 -0.3 1.39890652E8 -8210000.0 -0.23 -0.377 -0.9914 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H15 mock treatment 1.43537129E8 -7210000.0 -0.19 1.43299472E8 -4800000.0 -0.14 -0.2292 -0.9866 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H16 mock treatment 1.4175981E8 -8990000.0 -0.24 1.38095668E8 -1.0E7 -0.28 -0.3658 -0.996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H17 mock treatment 1.50567538E8 -184000.0 0.0 1.46571696E8 -1530000.0 -0.04 -0.0338 -0.7813 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H18 mock treatment 1.50519949E8 -231000.0 -0.01 1.41463364E8 -6640000.0 -0.19 -0.1365 -0.7296 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H19 mock treatment 1.4891514E8 -1840000.0 -0.05 1.50927835E8 2830000.0 0.08 0.0224 0.2405 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H20 mock treatment 1.53541517E8 2790000.0 0.07 1.49425887E8 1330000.0 0.04 0.0781 0.9517 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H21 mock treatment 1.61322219E8 1.06E7 0.28 1.56075511E8 7980000.0 0.22 0.3546 0.9947 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H22 mock treatment 1.6347778E8 1.27E7 0.33 1.61616642E8 1.35E7 0.38 0.5049 0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H23 mock treatment 1.7536219E8 2.46E7 0.64 1.68881965E8 2.08E7 0.59 0.8697 0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon H24 mock treatment 1.90415276E8 3.97E7 1.04 1.9185242E8 4.38E7 1.23 1.606 0.9963 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I01 positive control 5.4954515E7 -9.58E7 -2.51 4.9219871E7 -9.89E7 -2.79 -3.7435 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I02 positive control 5.0948875E7 -9.98E7 -2.61 4.4214315E7 -1.04E8 -2.93 -3.9174 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I03 positive control 4.9834068E7 -1.01E8 -2.64 4.0870219E7 -1.07E8 -3.02 -4.0046 -0.9978 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I04 positive control 4.8186458E7 -1.03E8 -2.68 4.2104577E7 -1.06E8 -2.99 -4.0105 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I05 positive control 4.9504454E7 -1.01E8 -2.65 4.3375772E7 -1.05E8 -2.95 -3.9608 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I06 positive control 4.2644547E7 -1.08E8 -2.83 4.1948871E7 -1.06E8 -2.99 -4.1162 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I07 positive control 4.4033102E7 -1.07E8 -2.79 4.6434022E7 -1.02E8 -2.86 -4.0012 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I08 positive control 4.3113592E7 -1.08E8 -2.82 4.3247789E7 -1.05E8 -2.95 -4.0817 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I09 positive control 4.8201961E7 -1.03E8 -2.68 4.3162455E7 -1.05E8 -2.96 -3.9892 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I10 positive control 4.3638645E7 -1.07E8 -2.8 4.2863383E7 -1.05E8 -2.97 -4.0796 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I11 positive control 4.2887624E7 -1.08E8 -2.82 4.5006507E7 -1.03E8 -2.91 -4.0508 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I12 positive control 4.7107683E7 -1.04E8 -2.71 4.5841152E7 -1.02E8 -2.88 -3.9561 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I13 mock treatment 1.33040508E8 -1.77E7 -0.46 1.32746799E8 -1.54E7 -0.43 -0.6337 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I14 mock treatment 1.43004817E8 -7750000.0 -0.2 1.38997189E8 -9100000.0 -0.26 -0.3247 -0.9932 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I15 mock treatment 1.47053191E8 -3700000.0 -0.1 1.43589256E8 -4510000.0 -0.13 -0.1583 -0.991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I16 mock treatment 1.43569242E8 -7180000.0 -0.19 1.40186964E8 -7910000.0 -0.22 -0.2906 -0.9964 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I17 mock treatment 1.48715492E8 -2040000.0 -0.05 1.48777283E8 679000.0 0.02 -0.0242 -0.4266 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I18 mock treatment 1.47202692E8 -3550000.0 -0.09 1.44122254E8 -3980000.0 -0.11 -0.1449 -0.9957 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I19 mock treatment 1.49164325E8 -1590000.0 -0.04 1.4806607E8 -32400.0 0.0 -0.03 -0.7225 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I20 mock treatment 1.51726939E8 976000.0 0.03 1.52602625E8 4500000.0 0.13 0.1078 0.8327 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I21 mock treatment 1.56381798E8 5630000.0 0.15 1.56491691E8 8390000.0 0.24 0.2715 0.9741 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I22 mock treatment 1.63711599E8 1.3E7 0.34 1.61992217E8 1.39E7 0.39 0.5167 0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I23 mock treatment 1.73111318E8 2.24E7 0.59 1.68289656E8 2.02E7 0.57 0.8162 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon I24 mock treatment 1.9474938E8 4.4E7 1.15 1.90944621E8 4.28E7 1.21 1.6682 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J01 positive control 5.2074236E7 -9.87E7 -2.58 4.8306459E7 -9.98E7 -2.81 -3.815 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J02 positive control 4.9790154E7 -1.01E8 -2.64 4.2485879E7 -1.06E8 -2.98 -3.9733 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J03 positive control 4.333039E7 -1.07E8 -2.81 4.6115233E7 -1.02E8 -2.87 -4.0205 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J04 positive control 4.4980293E7 -1.06E8 -2.77 3.7368798E7 -1.11E8 -3.12 -4.1643 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J05 positive control 4.5481408E7 -1.05E8 -2.76 4.0631393E7 -1.07E8 -3.03 -4.09 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J06 positive control 4.2856803E7 -1.08E8 -2.82 3.8844834E7 -1.09E8 -3.08 -4.1742 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J07 positive control 4.2687023E7 -1.08E8 -2.83 3.9652461E7 -1.08E8 -3.06 -4.1612 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J08 positive control 4.0685695E7 -1.1E8 -2.88 3.8173872E7 -1.1E8 -3.1 -4.2277 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J09 positive control 4.4329525E7 -1.06E8 -2.79 4.206792E7 -1.06E8 -2.99 -4.0827 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J10 positive control 4.3298729E7 -1.07E8 -2.81 4.1047637E7 -1.07E8 -3.02 -4.1221 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J11 positive control 4.6950802E7 -1.04E8 -2.72 4.4888441E7 -1.03E8 -2.91 -3.9779 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J12 positive control 4.2599471E7 -1.08E8 -2.83 4.2107551E7 -1.06E8 -2.99 -4.1139 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J13 mock treatment 1.35870794E8 -1.49E7 -0.39 1.32785761E8 -1.53E7 -0.43 -0.5806 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J14 mock treatment 1.35216151E8 -1.55E7 -0.41 1.35489801E8 -1.26E7 -0.36 -0.5388 -0.9977 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J15 mock treatment 1.43044373E8 -7710000.0 -0.2 1.39845688E8 -8250000.0 -0.23 -0.3071 -0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J16 mock treatment 1.37184286E8 -1.36E7 -0.36 1.40430722E8 -7670000.0 -0.22 -0.4039 -0.9716 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J17 mock treatment 1.46910642E8 -3840000.0 -0.1 1.38605633E8 -9490000.0 -0.27 -0.2602 -0.9107 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J18 mock treatment 1.46179784E8 -4570000.0 -0.12 1.4045901E8 -7640000.0 -0.22 -0.2368 -0.9616 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J19 mock treatment 1.4727552E8 -3480000.0 -0.09 1.42077979E8 -6020000.0 -0.17 -0.1843 -0.9573 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J20 mock treatment 1.51400071E8 649000.0 0.02 1.51406696E8 3310000.0 0.09 0.0779 0.8224 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J21 mock treatment 1.55604185E8 4850000.0 0.13 1.56642774E8 8540000.0 0.24 0.2601 0.9554 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J22 mock treatment 1.6122014E8 1.05E7 0.27 1.6565629E8 1.76E7 0.49 0.5436 0.9612 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J23 mock treatment 1.8259142E8 3.18E7 0.83 1.76661678E8 2.86E7 0.8 1.1585 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon J24 mock treatment 1.89766411E8 3.9E7 1.02 1.9092488E8 4.28E7 1.21 1.5755 0.9965 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K01 positive control 5.7414492E7 -9.33E7 -2.44 5.0936067E7 -9.72E7 -2.74 -3.6638 -0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K02 positive control 4.5993701E7 -1.05E8 -2.74 4.5662531E7 -1.02E8 -2.89 -3.9802 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K03 positive control 4.9284706E7 -1.01E8 -2.66 3.8984202E7 -1.09E8 -3.07 -4.0524 -0.9973 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K04 positive control 4.7335497E7 -1.03E8 -2.71 4.1761058E7 -1.06E8 -3.0 -4.0331 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K05 positive control 4.1310352E7 -1.09E8 -2.86 3.7425821E7 -1.11E8 -3.12 -4.2311 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K06 positive control 4.321526E7 -1.08E8 -2.81 4.0285649E7 -1.08E8 -3.04 -4.1388 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K07 positive control 4.5095326E7 -1.06E8 -2.77 3.909914E7 -1.09E8 -3.07 -4.1276 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K08 positive control 4.0842535E7 -1.1E8 -2.88 3.7253484E7 -1.11E8 -3.12 -4.2431 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K09 positive control 4.5673549E7 -1.05E8 -2.75 4.2917384E7 -1.05E8 -2.96 -4.0409 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K10 positive control 4.2819215E7 -1.08E8 -2.83 3.934662E7 -1.09E8 -3.06 -4.1648 -0.9992 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K11 positive control 4.8373562E7 -1.02E8 -2.68 4.7386797E7 -1.01E8 -2.84 -3.9018 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K12 positive control 4.2986786E7 -1.08E8 -2.82 4.4060299E7 -1.04E8 -2.93 -4.0678 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K13 mock treatment 1.34380444E8 -1.64E7 -0.43 1.36907303E8 -1.12E7 -0.32 -0.526 -0.9886 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K14 mock treatment 1.34794565E8 -1.6E7 -0.42 1.30470129E8 -1.76E7 -0.5 -0.6466 -0.9963 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K15 mock treatment 1.41839411E8 -8910000.0 -0.23 1.40771691E8 -7330000.0 -0.21 -0.311 -0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K16 mock treatment 1.43796077E8 -6960000.0 -0.18 1.472658E8 -833000.0 -0.02 -0.1453 -0.7917 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K17 mock treatment 1.36852082E8 -1.39E7 -0.36 1.39880217E8 -8220000.0 -0.23 -0.421 -0.9762 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K18 mock treatment 1.45156083E8 -5600000.0 -0.15 1.40903418E8 -7200000.0 -0.2 -0.2469 -0.9873 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K19 mock treatment 1.4594554E8 -4810000.0 -0.13 1.49308441E8 1210000.0 0.03 -0.0648 -0.4975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K20 mock treatment 1.5231485E8 1560000.0 0.04 1.557818E8 7680000.0 0.22 0.182 0.8261 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K21 mock treatment 1.53879779E8 3130000.0 0.08 1.51201133E8 3100000.0 0.09 0.1197 0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K22 mock treatment 1.5876863E8 8020000.0 0.21 1.59350487E8 1.13E7 0.32 0.3726 0.9799 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K23 mock treatment 1.62416155E8 1.17E7 0.31 1.64400215E8 1.63E7 0.46 0.5408 0.9803 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon K24 mock treatment 1.88732553E8 3.8E7 0.99 1.90404331E8 4.23E7 1.19 1.546 0.9959 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L01 positive control 5.1811323E7 -9.89E7 -2.59 4.9680252E7 -9.84E7 -2.77 -3.7925 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L02 positive control 4.6455234E7 -1.04E8 -2.73 4.3526524E7 -1.05E8 -2.95 -4.0143 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L03 positive control 5.3208216E7 -9.75E7 -2.55 4.693099E7 -1.01E8 -2.85 -3.8214 -0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L04 positive control 4.3497489E7 -1.07E8 -2.81 3.3147054E7 -1.15E8 -3.24 -4.2758 -0.9975 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L05 positive control 4.3730871E7 -1.07E8 -2.8 3.9290881E7 -1.09E8 -3.07 -4.1491 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L06 positive control 4.2161026E7 -1.09E8 -2.84 3.8127907E7 -1.1E8 -3.1 -4.2013 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L07 positive control 4.4412275E7 -1.06E8 -2.78 4.3449563E7 -1.05E8 -2.95 -4.0536 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L08 positive control 4.1964206E7 -1.09E8 -2.85 4.1092037E7 -1.07E8 -3.02 -4.1459 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L09 positive control 3.8687916E7 -1.12E8 -2.93 4.0267283E7 -1.08E8 -3.04 -4.223 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L10 positive control 4.7333642E7 -1.03E8 -2.71 4.5310578E7 -1.03E8 -2.9 -3.9624 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L11 positive control 4.0108386E7 -1.11E8 -2.9 3.6382562E7 -1.12E8 -3.15 -4.2741 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L12 positive control 4.187145E7 -1.09E8 -2.85 4.3383652E7 -1.05E8 -2.95 -4.1019 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L13 mock treatment 1.31119029E8 -1.96E7 -0.51 1.27306357E8 -2.08E7 -0.59 -0.7777 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L14 mock treatment 1.31805986E8 -1.89E7 -0.5 1.39395268E8 -8700000.0 -0.25 -0.5241 -0.9473 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L15 mock treatment 1.39768317E8 -1.1E7 -0.29 1.35225786E8 -1.29E7 -0.36 -0.4598 -0.9934 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L16 mock treatment 1.42651914E8 -8100000.0 -0.21 1.31644913E8 -1.65E7 -0.46 -0.4778 -0.9371 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L17 mock treatment 1.49519846E8 -1230000.0 -0.03 1.37402014E8 -1.07E7 -0.3 -0.2359 -0.7783 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L18 mock treatment 1.399814E8 -1.08E7 -0.28 1.36773728E8 -1.13E7 -0.32 -0.425 -0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L19 mock treatment 1.38037411E8 -1.27E7 -0.33 1.44752889E8 -3350000.0 -0.09 -0.302 -0.8731 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L20 mock treatment 1.58295538E8 7540000.0 0.2 1.55459122E8 7360000.0 0.21 0.2863 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L21 mock treatment 1.49685591E8 -1070000.0 -0.03 1.41979525E8 -6120000.0 -0.17 -0.1417 -0.811 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L22 mock treatment 1.52632633E8 1880000.0 0.05 1.52203467E8 4110000.0 0.12 0.1166 0.9276 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L23 mock treatment 1.67875323E8 1.71E7 0.45 1.65673618E8 1.76E7 0.5 0.6672 0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon L24 mock treatment 1.86623546E8 3.59E7 0.94 1.8404619E8 3.59E7 1.01 1.3803 0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M01 positive control 6.271696E7 -8.8E7 -2.3 6.0837466E7 -8.73E7 -2.46 -3.3683 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M02 positive control 4.7748877E7 -1.03E8 -2.7 4.1265903E7 -1.07E8 -3.01 -4.0354 -0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M03 positive control 4.3823954E7 -1.07E8 -2.8 3.7943504E7 -1.1E8 -3.1 -4.1742 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M04 positive control 4.2402762E7 -1.08E8 -2.84 3.8192946E7 -1.1E8 -3.1 -4.1955 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M05 positive control 4.8621907E7 -1.02E8 -2.67 4.8394067E7 -9.97E7 -2.81 -3.8772 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M06 positive control 4.0643011E7 -1.1E8 -2.88 3.7812496E7 -1.1E8 -3.11 -4.2357 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M07 positive control 4.206912E7 -1.09E8 -2.84 3.906306E7 -1.09E8 -3.07 -4.1844 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M08 positive control 4.736102E7 -1.03E8 -2.71 4.6039385E7 -1.02E8 -2.88 -3.9474 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M09 positive control 4.1988969E7 -1.09E8 -2.85 4.332568E7 -1.05E8 -2.95 -4.1009 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M10 positive control 4.1301637E7 -1.09E8 -2.87 4.2472303E7 -1.06E8 -2.98 -4.1307 -0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M11 positive control 4.0005805E7 -1.11E8 -2.9 3.5178191E7 -1.13E8 -3.18 -4.3 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M12 positive control 4.5782993E7 -1.05E8 -2.75 3.9113315E7 -1.09E8 -3.07 -4.1146 -0.9985 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M13 mock treatment 1.19398274E8 -3.14E7 -0.82 1.17269471E8 -3.08E7 -0.87 -1.1947 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M14 mock treatment 1.23623959E8 -2.71E7 -0.71 1.21586895E8 -2.65E7 -0.75 -1.0304 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M15 mock treatment 1.206949E8 -3.01E7 -0.79 1.28804014E8 -1.93E7 -0.54 -0.9408 -0.9837 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M16 mock treatment 1.28711404E8 -2.2E7 -0.58 1.19523029E8 -2.86E7 -0.81 -0.9774 -0.9866 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M17 mock treatment 1.44064902E8 -6690000.0 -0.18 1.40961797E8 -7140000.0 -0.2 -0.266 -0.9976 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M18 mock treatment 1.47174442E8 -3580000.0 -0.09 1.49876543E8 1780000.0 0.05 -0.0308 -0.2898 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M19 mock treatment 1.42602984E8 -8150000.0 -0.21 1.37092106E8 -1.1E7 -0.31 -0.3701 -0.9833 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M20 mock treatment 1.43631358E8 -7120000.0 -0.19 1.35854186E8 -1.22E7 -0.35 -0.3758 -0.9582 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M21 mock treatment 1.69993977E8 1.92E7 0.5 1.6572496E8 1.76E7 0.5 0.7074 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M22 mock treatment 1.54583044E8 3830000.0 0.1 1.57768784E8 9670000.0 0.27 0.2636 0.9078 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M23 mock treatment 1.67659435E8 1.69E7 0.44 1.65396905E8 1.73E7 0.49 0.6577 0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon M24 mock treatment 1.8932779E8 3.86E7 1.01 1.85906316E8 3.78E7 1.07 1.4674 0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N01 positive control 5.4282853E7 -9.65E7 -2.53 5.3845445E7 -9.43E7 -2.66 -3.6637 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N02 positive control 5.4627347E7 -9.61E7 -2.52 5.2821569E7 -9.53E7 -2.68 -3.6778 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N03 positive control 4.4813942E7 -1.06E8 -2.77 3.8807137E7 -1.09E8 -3.08 -4.1387 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N04 positive control 4.2531639E7 -1.08E8 -2.83 3.7810404E7 -1.1E8 -3.11 -4.2008 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N05 positive control 4.121044E7 -1.1E8 -2.87 3.7011639E7 -1.11E8 -3.13 -4.2412 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N06 positive control 4.0024198E7 -1.11E8 -2.9 3.5448346E7 -1.13E8 -3.17 -4.2943 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N07 positive control 4.2023803E7 -1.09E8 -2.85 3.6746378E7 -1.11E8 -3.14 -4.2314 -0.9988 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N08 positive control 4.1639135E7 -1.09E8 -2.86 3.6870454E7 -1.11E8 -3.13 -4.236 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N09 positive control 4.1219965E7 -1.1E8 -2.87 3.6474329E7 -1.12E8 -3.15 -4.2517 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N10 positive control 3.8382005E7 -1.12E8 -2.94 3.8715221E7 -1.09E8 -3.08 -4.2596 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N11 positive control 3.8816272E7 -1.12E8 -2.93 3.8793676E7 -1.09E8 -3.08 -4.25 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N12 positive control 4.5626553E7 -1.05E8 -2.75 4.4677893E7 -1.03E8 -2.91 -4.0067 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N13 mock treatment 9.9713957E7 -5.1E7 -1.34 1.09785571E8 -3.83E7 -1.08 -1.7081 -0.9944 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N14 mock treatment 1.0869543E8 -4.21E7 -1.1 1.10310519E8 -3.78E7 -1.06 -1.5314 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N15 mock treatment 1.00880858E8 -4.99E7 -1.31 1.03071097E8 -4.5E7 -1.27 -1.8203 -0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N16 mock treatment 1.25747706E8 -2.5E7 -0.65 1.377589E8 -1.03E7 -0.29 -0.6688 -0.9336 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N17 mock treatment 1.41613005E8 -9140000.0 -0.24 1.40119983E8 -7980000.0 -0.22 -0.3281 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N18 mock treatment 1.32194401E8 -1.86E7 -0.49 1.40422059E8 -7680000.0 -0.22 -0.4964 -0.9336 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N19 mock treatment 1.42055366E8 -8700000.0 -0.23 1.41640324E8 -6460000.0 -0.18 -0.2896 -0.9939 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N20 mock treatment 1.64305046E8 1.36E7 0.35 1.60971242E8 1.29E7 0.36 0.5074 0.9999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N21 mock treatment 1.49925344E8 -826000.0 -0.02 1.42658447E8 -5440000.0 -0.15 -0.1237 -0.7989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N22 mock treatment 1.57529479E8 6780000.0 0.18 1.51220531E8 3120000.0 0.09 0.1877 0.9476 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N23 mock treatment 1.73240023E8 2.25E7 0.59 1.66054212E8 1.8E7 0.51 0.7741 0.9972 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon N24 mock treatment 1.9321823E8 4.25E7 1.11 1.92205496E8 4.41E7 1.24 1.665 0.9984 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O01 positive control 6.1838072E7 -8.89E7 -2.33 5.4878636E7 -9.32E7 -2.63 -3.5033 -0.9982 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O02 positive control 4.9316072E7 -1.01E8 -2.66 4.5759716E7 -1.02E8 -2.88 -3.9168 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O03 positive control 4.5807365E7 -1.05E8 -2.75 4.2014077E7 -1.06E8 -2.99 -4.0564 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O04 positive control 4.3764474E7 -1.07E8 -2.8 3.9995924E7 -1.08E8 -3.05 -4.1344 -0.9991 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O05 positive control 4.4695052E7 -1.06E8 -2.78 3.8748172E7 -1.09E8 -3.08 -4.1421 -0.9986 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O06 positive control 4.6606848E7 -1.04E8 -2.73 3.8762264E7 -1.09E8 -3.08 -4.1064 -0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O07 positive control 4.3103025E7 -1.08E8 -2.82 3.890145E7 -1.09E8 -3.08 -4.1685 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O08 positive control 4.09742E7 -1.1E8 -2.87 3.6720567E7 -1.11E8 -3.14 -4.2513 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O09 positive control 4.1527421E7 -1.09E8 -2.86 3.7014515E7 -1.11E8 -3.13 -4.2352 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O10 positive control 4.3166487E7 -1.08E8 -2.82 3.834387E7 -1.1E8 -3.09 -4.1784 -0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O11 positive control 4.1156434E7 -1.1E8 -2.87 3.6988265E7 -1.11E8 -3.13 -4.2426 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O12 positive control 4.1168626E7 -1.1E8 -2.87 3.8748004E7 -1.09E8 -3.08 -4.2073 -0.9994 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O13 mock treatment 1.38171629E8 -1.26E7 -0.33 1.2959487E8 -1.85E7 -0.52 -0.6016 -0.9754 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O14 mock treatment 1.42264988E8 -8490000.0 -0.22 1.37650777E8 -1.04E7 -0.29 -0.3653 -0.9904 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O15 mock treatment 1.42696643E8 -8050000.0 -0.21 1.2945212E8 -1.86E7 -0.53 -0.5206 -0.9196 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O16 mock treatment 1.3294871E8 -1.78E7 -0.47 1.28251771E8 -1.98E7 -0.56 -0.725 -0.9959 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O17 mock treatment 1.52574926E8 1820000.0 0.05 1.59445635E8 1.13E7 0.32 0.2599 0.8038 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O18 mock treatment 1.52714004E8 1960000.0 0.05 1.42631144E8 -5470000.0 -0.15 -0.0726 -0.4471 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O19 mock treatment 1.47450472E8 -3300000.0 -0.09 1.35165349E8 -1.29E7 -0.36 -0.3188 -0.8512 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O20 mock treatment 1.5395667E8 3210000.0 0.08 1.48494757E8 396000.0 0.01 0.0672 0.7942 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O21 mock treatment 1.78771165E8 2.8E7 0.73 1.74245079E8 2.61E7 0.74 1.0397 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O22 mock treatment 1.65987967E8 1.52E7 0.4 1.59833841E8 1.17E7 0.33 0.5159 0.9957 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O23 mock treatment 1.76124608E8 2.54E7 0.66 1.72943591E8 2.48E7 0.7 0.9647 0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon O24 mock treatment 1.88870077E8 3.81E7 1.0 1.91977174E8 4.39E7 1.24 1.5799 0.9943 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P01 positive control 7.4673469E7 -7.61E7 -1.99 7.0683836E7 -7.74E7 -2.18 -2.9508 -0.999 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P02 positive control 5.5780543E7 -9.5E7 -2.49 4.7496091E7 -1.01E8 -2.84 -3.7625 -0.9979 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P03 positive control 5.2566225E7 -9.82E7 -2.57 5.0741619E7 -9.74E7 -2.74 -3.7574 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P04 positive control 5.1090513E7 -9.97E7 -2.61 4.8391227E7 -9.97E7 -2.81 -3.8315 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P05 positive control 5.3536492E7 -9.72E7 -2.54 4.6068382E7 -1.02E8 -2.88 -3.8325 -0.9981 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P06 positive control 4.6471378E7 -1.04E8 -2.73 4.4908607E7 -1.03E8 -2.91 -3.9864 -0.9995 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P07 positive control 5.094417E7 -9.98E7 -2.61 4.5289879E7 -1.03E8 -2.9 -3.896 -0.9987 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P08 positive control 5.2558753E7 -9.82E7 -2.57 4.5654472E7 -1.02E8 -2.89 -3.8589 -0.9983 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P09 positive control 5.2042748E7 -9.87E7 -2.58 4.3062133E7 -1.05E8 -2.96 -3.9201 -0.9977 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P10 positive control 5.2496764E7 -9.83E7 -2.57 5.1576167E7 -9.65E7 -2.72 -3.742 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P11 positive control 4.3280667E7 -1.07E8 -2.81 4.2924666E7 -1.05E8 -2.96 -4.085 -0.9997 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P12 positive control 4.309807E7 -1.08E8 -2.82 4.216382E7 -1.06E8 -2.99 -4.1036 -0.9996 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P13 mock treatment 1.49401262E8 -1350000.0 -0.04 1.49268903E8 1170000.0 0.03 -0.0017 -0.0345 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P14 mock treatment 1.49517308E8 -1230000.0 -0.03 1.47035006E8 -1060000.0 -0.03 -0.044 -0.9993 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P15 mock treatment 1.68271333E8 1.75E7 0.46 1.7630785E8 2.82E7 0.79 0.8864 0.9658 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P16 mock treatment 1.52789307E8 2040000.0 0.05 1.51846788E8 3750000.0 0.11 0.1124 0.95 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P17 mock treatment 1.53339269E8 2590000.0 0.07 1.47260278E8 -838000.0 -0.02 0.0312 0.4349 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P18 mock treatment 1.5692698E8 6180000.0 0.16 1.53312056E8 5210000.0 0.15 0.2182 0.9989 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P19 mock treatment 1.54528222E8 3780000.0 0.1 1.52350417E8 4250000.0 0.12 0.1546 0.9954 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P20 mock treatment 1.65189477E8 1.44E7 0.38 1.66991589E8 1.89E7 0.53 0.6437 0.9859 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P21 mock treatment 1.66998717E8 1.62E7 0.43 1.6747394E8 1.94E7 0.55 0.6868 0.9924 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P22 mock treatment 1.90318253E8 3.96E7 1.04 1.84565115E8 3.65E7 1.03 1.459 1.0 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P23 mock treatment 1.98065592E8 4.73E7 1.24 1.90267748E8 4.22E7 1.19 1.7161 0.9998 1111.0004 CellTiterBlue(1111.0004) GSISyntheticLethal 1111.0004.PosCon P24 mock treatment 2.39687898E8 8.89E7 2.33 2.3301558E8 8.49E7 2.39 3.3383 0.9999