ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A01 mock treatment 1.19581189E8 9530000.0 0.54 1.11930356E8 5220000.0 0.32 0.6125 0.9684 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A02 mock treatment 1.12141088E8 2090000.0 0.12 1.03021174E8 -3690000.0 -0.23 -0.0765 -0.2975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A03 compound treatment 9.8479712E7 -1.16E7 -0.66 9.9602383E7 -7110000.0 -0.44 -0.7776 -0.9801 985 SPBio_000001 Nc1ccc(C(=O)O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A04 compound treatment 1.09848675E8 -202000.0 -0.01 1.05511001E8 -1200000.0 -0.07 -0.0606 -0.8072 1408 SPBio_000002 NC1(CC2CC3CC(C2)C1)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A05 compound treatment 8.8571584E7 -2.15E7 -1.23 9.1268545E7 -1.54E7 -0.95 -1.5413 -0.9921 1367 SPBio_000003 Cc1cc(O)ccc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A06 compound treatment 8.813233E7 -2.19E7 -1.25 9.2675715E7 -1.4E7 -0.87 -1.4977 -0.9837 692 SPBio_000004 CC(=O)Nc1nnc(s1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A07 compound treatment 8.5416609E7 -2.46E7 -1.41 8.8314283E7 -1.84E7 -1.13 -1.7975 -0.9943 1001324 SPBio_000005 OC(=O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A08 compound treatment 8.5861737E7 -2.42E7 -1.38 8.842825E7 -1.83E7 -1.13 -1.7746 -0.9949 2550 SPBio_000006 O[C@@H]([C@@H](COC(=O)CCC(=O)O)NC(=O)C(Cl)Cl)c1ccc(cc1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A09 compound treatment 8.0465829E7 -2.96E7 -1.69 8.5642154E7 -2.11E7 -1.3 -2.1141 -0.9915 3058614 SPBio_000007 C[C@@H](CO)NC(=O)C1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A10 compound treatment 8.3929909E7 -2.61E7 -1.49 8.5022813E7 -2.17E7 -1.34 -2.0011 -0.9985 760 SPBio_000008 N[C@@H]1CONC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A11 compound treatment 7.8700516E7 -3.13E7 -1.79 8.3636389E7 -2.31E7 -1.42 -2.2729 -0.9935 3199904 SPBio_000009 OC(=O)c1ccccc1OC(=O)/C=C/C(=O)Oc2ccccc2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A12 compound treatment 8.042777E7 -2.96E7 -1.69 8.0071211E7 -2.66E7 -1.64 -2.3585 -0.9999 1267 SPBio_000010 CC(=O)Nc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A13 compound treatment 8.794874E7 -2.21E7 -1.26 8.3582771E7 -2.31E7 -1.43 -1.9015 -0.9982 1300 SPBio_000011 OC(=O)c1cccnc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A14 compound treatment 8.8048595E7 -2.2E7 -1.26 7.311257E7 -3.36E7 -2.07 -2.3538 -0.9714 1001897 SPBio_000012 CC(=O)N[C@@H](CS)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A15 compound treatment 4.0690614E7 -6.94E7 -3.96 4.0515762E7 -6.62E7 -4.08 -5.6885 -0.9999 3174099 SPBio_000013 Nc1cccc(c1)C(=C2C=CC(=N)C=C2)c3cccc(N)c3.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A16 compound treatment 8.7282679E7 -2.28E7 -1.3 8.9054329E7 -1.77E7 -1.09 -1.6899 -0.9961 1037 SPBio_000014 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A17 compound treatment 9.1701068E7 -1.83E7 -1.05 8.7838294E7 -1.89E7 -1.16 -1.5643 -0.9987 1199 SPBio_000015 CSCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A18 compound treatment 1.07801473E8 -2250000.0 -0.13 1.00870128E8 -5840000.0 -0.36 -0.3456 -0.9036 1108 SPBio_000016 Cc1cc(=O)n(c2ccccc2)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A19 compound treatment 9.4111161E7 -1.59E7 -0.91 9.3101393E7 -1.36E7 -0.84 -1.2375 -0.9992 1096 SPBio_000017 C[N+](C)(C)CC(O)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A20 compound treatment 1.03202278E8 -6850000.0 -0.39 9.9678993E7 -7040000.0 -0.43 -0.5834 -0.9987 1132 SPBio_000018 CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A21 compound treatment 1.01590186E8 -8460000.0 -0.48 1.00519186E8 -6200000.0 -0.38 -0.6119 -0.9932 3059433 SPBio_000019 CC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A22 compound treatment 4.4121763E7 -6.59E7 -3.77 4.2412074E7 -6.43E7 -3.96 -5.4671 -0.9997 697 SPBio_000020 Cn1c(=O)n(C)c2ncn(CC(O)CO)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A23 mock treatment 1.20092543E8 1.0E7 0.57 1.10887191E8 4170000.0 0.26 0.5877 0.9344 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 A24 mock treatment 1.24532681E8 1.45E7 0.83 1.12034246E8 5320000.0 0.33 0.8171 0.9178 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B01 mock treatment 1.19242875E8 9190000.0 0.53 1.16168517E8 9450000.0 0.58 0.7836 0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B02 mock treatment 9.7163619E7 -1.29E7 -0.74 9.4083178E7 -1.26E7 -0.78 -1.0714 -0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B03 compound treatment 8.3519517E7 -2.65E7 -1.52 8.6050272E7 -2.07E7 -1.27 -1.9729 -0.9962 2060046 SPBio_000021 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)[C@@]4(C)O[C@]43[C@H]2OC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B04 compound treatment 8.3336248E7 -2.67E7 -1.53 8.4852944E7 -2.19E7 -1.35 -2.0325 -0.9981 2060083 SPBio_000022 COC(=O)C(O)[C@H]1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B05 compound treatment 9.3681874E7 -1.64E7 -0.94 8.9078744E7 -1.76E7 -1.09 -1.4302 -0.9972 2060226 SPBio_000023 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cc(cc34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B06 compound treatment 8.2381048E7 -2.77E7 -1.58 8.2792572E7 -2.39E7 -1.47 -2.1609 -0.9994 2060085 SPBio_000024 C[C@]12CCC3[C@@](C)([C@H](O)CC4[C@]3(C)C=CC(=O)OC4(C)C)C25OC5C(=O)O[C@H]1c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B07 compound treatment 7.8875481E7 -3.12E7 -1.78 7.801833E7 -2.87E7 -1.77 -2.5107 -1.0 2060422 SPBio_000025 CCOc1ccc(cc1)C(=O)c2cc(O)c(OC)c(OC)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B08 compound treatment 8.2561364E7 -2.75E7 -1.57 8.7314501E7 -1.94E7 -1.2 -1.9565 -0.9909 2069252 SPBio_000026 CCC(C)C(OC(=O)C)C(=O)O[C@H]1[C@H](OC=O)C(C(=C)C2(O)C(=O)C[C@@H](c3ccoc3)[C@]12C)[C@]4(C)C(CC(=O)OC)[C@@](C)(COC(=O)C)OC(=O)C[C@@H]4OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B09 compound treatment 7.0731932E7 -3.93E7 -2.25 7.8164522E7 -2.86E7 -1.76 -2.8334 -0.9927 2060223 SPBio_000027 COc1cc(OC)c2C[C@H](O)[C@H](Oc2c1)c3ccc(OC)c(OC)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B10 compound treatment 7.2431119E7 -3.76E7 -2.15 7.6952045E7 -2.98E7 -1.83 -2.8176 -0.9969 2060087 SPBio_000028 COC(=O)C(O)[C@H]1C(C)(C)C(OC(=O)/C(=C/C)/C)[C@@H]2C=C3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B11 compound treatment 6.7042112E7 -4.3E7 -2.46 7.1457054E7 -3.53E7 -2.17 -3.2749 -0.9981 2060224 SPBio_000029 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B12 compound treatment 7.938959E7 -3.07E7 -1.75 7.8856932E7 -2.79E7 -1.72 -2.4533 -0.9999 2060090 SPBio_000030 COC(=O)C[C@H]1C(C)(C)C(OC(=O)C)[C@]2(O)C=C3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B13 compound treatment 7.1641442E7 -3.84E7 -2.2 7.1883188E7 -3.48E7 -2.15 -3.0704 -0.9999 2060169 SPBio_000031 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4c5c(O)c(O)c(O)cc5[C@H]6Oc7cc(O)cc(O)c7C[C@H]6OC(=O)c8cc(O)c(O)c(O)c8 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B14 compound treatment 7.5546335E7 -3.45E7 -1.97 7.5112446E7 -3.16E7 -1.95 -2.7719 -1.0 2060089 SPBio_000032 CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@@H](OC(=O)CC32OC4(C)O[C@]53[C@H](OC(=O)C)[C@@]6(O)C(OC(=O)C7(C)OC7C)C8(C)CC6(O)[C@@](C)([C@H]8CC(=O)OC)[C@@]15O4)c9ccoc9 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B15 compound treatment 8.0058053E7 -3.0E7 -1.71 7.7705677E7 -2.9E7 -1.79 -2.4765 -0.9998 1254 SPBio_000033 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B16 compound treatment 8.1950373E7 -2.81E7 -1.61 9.8934938E7 -7780000.0 -0.48 -1.4747 -0.8799 2060091 SPBio_000034 CC(CC(O)C1OC1(C)C)[C@@H]2CCC3(C)C4=CCC5C(C)(C)C(=O)CCC5(C)C4CC[C@@]23C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B17 compound treatment 8.2874313E7 -2.72E7 -1.55 8.2936235E7 -2.38E7 -1.47 -2.1347 -0.9996 1859 SPBio_000035 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B18 compound treatment 8.1583597E7 -2.85E7 -1.63 8.1520428E7 -2.52E7 -1.55 -2.2486 -0.9997 2060093 SPBio_000036 CC([C@@H]1CC[C@]2(C)C3=CCC4C(C)(C)C(=O)CC[C@]4(C)C3CC[C@@]12C)C5OC(C)(C)C(O)C5O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B19 compound treatment 8.4127134E7 -2.59E7 -1.48 8.0640297E7 -2.61E7 -1.61 -2.1841 -0.9992 2060218 SPBio_000037 COc1c(CC(=O)c2cc3CC(O)C(C)(C)Oc3cc2O)ccc4OC(C)(C)C=Cc14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B20 compound treatment 9.6267681E7 -1.38E7 -0.79 9.4315459E7 -1.24E7 -0.76 -1.0974 -0.9999 2060094 SPBio_000038 COC(=O)C(O)[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B21 compound treatment 9.0510712E7 -1.95E7 -1.12 8.8337575E7 -1.84E7 -1.13 -1.5907 -1.0 3054028 SPBio_000039 CC(CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=C(CC[C@@]12C)C4(C)CC[C@H](O)C(C)(C)C4CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B22 compound treatment 9.4505788E7 -1.55E7 -0.89 8.8970214E7 -1.77E7 -1.09 -1.4016 -0.9947 2060115 SPBio_000040 CC(=CCOc1cc2oc(=O)ccc2cc1O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B23 mock treatment 9.712203E7 -1.29E7 -0.74 9.2840637E7 -1.39E7 -0.86 -1.1272 -0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 B24 mock treatment 1.23122293E8 1.31E7 0.75 1.17600717E8 1.09E7 0.67 1.0028 0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C01 mock treatment 1.05803526E8 -4250000.0 -0.24 1.05253327E8 -1460000.0 -0.09 -0.2353 -0.909 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C02 mock treatment 9.5975232E7 -1.41E7 -0.8 9.2564359E7 -1.42E7 -0.87 -1.1856 -0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C03 compound treatment 9.1301308E7 -1.87E7 -1.07 9.2417287E7 -1.43E7 -0.88 -1.3809 -0.9953 2069233 SPBio_000041 COc1ccc2C3CCC4(C)C(O)[C@H](O)CC4C3CCc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C04 compound treatment 7.104476E7 -3.9E7 -2.23 8.3581847E7 -2.31E7 -1.43 -2.5846 -0.9767 844 SPBio_000042 CNCCCN1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C05 compound treatment 1.02824956E8 -7230000.0 -0.41 1.00517793E8 -6200000.0 -0.38 -0.5621 -0.9992 2069241 SPBio_000043 COc1ccc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C06 compound treatment 8.815603E7 -2.19E7 -1.25 9.1796999E7 -1.49E7 -0.92 -1.535 -0.9885 678 SPBio_000044 NCC(CC(=O)O)c1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C07 compound treatment 8.6524992E7 -2.35E7 -1.34 8.4118201E7 -2.26E7 -1.39 -1.9356 -0.9998 1094519 SPBio_000045 CC(=O)N1CCCC1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C08 compound treatment 8.6149104E7 -2.39E7 -1.37 8.5498048E7 -2.12E7 -1.31 -1.8907 -0.9998 1469 SPBio_000046 CCC1(CCC(=O)NC1=O)c2ccc(N)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C09 compound treatment 8.1881146E7 -2.82E7 -1.61 8.2785526E7 -2.39E7 -1.48 -2.1814 -0.999 736 SPBio_000047 COC(=O)C(N)CS 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C10 compound treatment 7.9928436E7 -3.01E7 -1.72 8.5780497E7 -2.09E7 -1.29 -2.1298 -0.9899 1000124 SPBio_000048 CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C11 compound treatment 8.4737613E7 -2.53E7 -1.45 8.5902972E7 -2.08E7 -1.28 -1.9301 -0.9982 978 SPBio_000049 COC(=O)C(C)C[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C12 compound treatment 7.8237706E7 -3.18E7 -1.82 7.9952438E7 -2.68E7 -1.65 -2.4521 -0.9988 997 SPBio_000050 NCc1ccc(cc1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C13 compound treatment 8.2272413E7 -2.78E7 -1.59 8.3833338E7 -2.29E7 -1.41 -2.1199 -0.9983 2069271 SPBio_000051 C[C@H](N)[C@H](O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C14 compound treatment 8.3227766E7 -2.68E7 -1.53 7.4912382E7 -3.18E7 -1.96 -2.4702 -0.9926 1252 SPBio_000052 CC(C)NCC(O)c1cc(O)cc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C15 compound treatment 7.8094947E7 -3.2E7 -1.83 7.7078692E7 -2.96E7 -1.83 -2.5832 -1.0 1404 SPBio_000053 Nc1ccc(N=Nc2ccccc2)c(N)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C16 compound treatment 6.4570794E7 -4.55E7 -2.6 6.7246042E7 -3.95E7 -2.43 -3.5583 -0.9995 1485 SPBio_000054 CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C17 compound treatment 8.3414671E7 -2.66E7 -1.52 8.2888359E7 -2.38E7 -1.47 -2.115 -0.9998 1090918 SPBio_000055 Cc1nc(C)c(Cl)c(O)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C18 compound treatment 8.5133184E7 -2.49E7 -1.42 8.047125E7 -2.62E7 -1.62 -2.1509 -0.998 1292 SPBio_000056 O=c1[nH]cnc2[nH]ncc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C19 compound treatment 8.5252293E7 -2.48E7 -1.42 8.4000678E7 -2.27E7 -1.4 -1.9922 -1.0 3182 SPBio_000057 CCCc1cc(ccn1)C(=S)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C20 compound treatment 8.9596905E7 -2.05E7 -1.17 9.2421903E7 -1.43E7 -0.88 -1.4496 -0.9903 1332 SPBio_000058 NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C21 compound treatment 9.7304649E7 -1.27E7 -0.73 8.9893898E7 -1.68E7 -1.04 -1.2483 -0.9851 3199905 SPBio_000059 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4c5nc6cc(C)ccn6c5c(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)C(O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)c(O)c4c(O)c3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C22 compound treatment 3.3834744E7 -7.62E7 -4.36 3.2130855E7 -7.46E7 -4.6 -6.331 -0.9996 3177311 SPBio_000060 C[C@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C23 mock treatment 1.04690824E8 -5360000.0 -0.31 8.9943393E7 -1.68E7 -1.03 -0.9476 -0.8788 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 C24 mock treatment 1.26018951E8 1.6E7 0.91 1.21720104E8 1.5E7 0.92 1.2994 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D01 mock treatment 1.05779265E8 -4270000.0 -0.24 1.0716981E8 455000.0 0.03 -0.1528 -0.6218 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D02 mock treatment 9.5613498E7 -1.44E7 -0.83 9.1676409E7 -1.5E7 -0.93 -1.2389 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D03 compound treatment 9.8766693E7 -1.13E7 -0.64 1.001541E8 -6560000.0 -0.4 -0.742 -0.9747 2069246 SPBio_000061 Cc1cc(O)c(C=O)c2Oc3c4C(O)OC(=O)c4c(O)c(C)c3OC(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D04 compound treatment 9.1928109E7 -1.81E7 -1.04 8.9864421E7 -1.69E7 -1.04 -1.4668 -1.0 2060364 SPBio_000062 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D05 compound treatment 9.1833388E7 -1.82E7 -1.04 8.17735E7 -2.49E7 -1.54 -1.8233 -0.982 3198309 SPBio_000063 CC(=O)OCC(O)CC(O)CCCCCCCCCCCC=C.CC(=O)OCC(O)CC(O)CCCCCCCCCCCC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D06 compound treatment 8.9911017E7 -2.01E7 -1.15 9.2127034E7 -1.46E7 -0.9 -1.4497 -0.9925 2060372 SPBio_000064 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3=C(CC[C@@]4(C)[C@@H](OC(=O)C=C34)c5ccoc5)[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D07 compound treatment 8.3473474E7 -2.66E7 -1.52 8.4008299E7 -2.27E7 -1.4 -2.0638 -0.9992 2060203 SPBio_000065 CCOC(=O)c1c(C)cc(O)c(C)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D08 compound treatment 6.7496375E7 -4.26E7 -2.43 7.5115706E7 -3.16E7 -1.95 -3.097 -0.9939 2060145 SPBio_000066 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)C=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D09 compound treatment 8.1187033E7 -2.89E7 -1.65 8.5895003E7 -2.08E7 -1.28 -2.0739 -0.9923 2060100 SPBio_000067 OC(=O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D10 compound treatment 7.8747233E7 -3.13E7 -1.79 8.0757473E7 -2.6E7 -1.6 -2.3965 -0.9984 2060127 SPBio_000068 COC1CC2=C3C[C@H]4C(=O)C(C)(C)[C@H](CC(=O)OC)[C@@](C)(C3CC[C@@]2(C)[C@@H](O1)c5ccoc5)C4=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D11 compound treatment 2.8625019E7 -8.14E7 -4.65 2.8116143E7 -7.86E7 -4.85 -6.7165 -0.9998 1017609 SPBio_000069 CC(=CCc1c(O)c2c(=O)c(coc2c3C=CC(C)(C)Oc13)c4ccc(O)cc4)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D12 compound treatment 7.7738004E7 -3.23E7 -1.85 7.6305954E7 -3.04E7 -1.87 -2.6313 -1.0 2060118 SPBio_000070 COC(=O)CC1C(C)(C)C(O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D13 compound treatment 4.1021731E7 -6.9E7 -3.95 4.2926111E7 -6.38E7 -3.93 -5.57 -1.0 2069330 SPBio_000071 COc1cc(O)c(C(=O)/C=C/c2ccccc2)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D14 compound treatment 8.6692464E7 -2.34E7 -1.33 7.9794687E7 -2.69E7 -1.66 -2.1173 -0.9942 2060121 SPBio_000072 COC(=O)C[C@H]1C(C)(C)C2(Cl)O[C@]34CC2C(=O)[C@]1(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C35)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D15 compound treatment 8.838056E7 -2.17E7 -1.24 8.6502552E7 -2.02E7 -1.25 -1.7567 -1.0 2060495 SPBio_000073 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3c4c(O)c(O)c(O)cc4[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D16 compound treatment 8.5335937E7 -2.47E7 -1.41 8.5259939E7 -2.15E7 -1.32 -1.9339 -0.9995 2060150 SPBio_000074 CC1(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]3(C)OC(=O)CC12)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D17 compound treatment 6.2087712E7 -4.8E7 -2.74 6.4194918E7 -4.25E7 -2.62 -3.7916 -0.9997 3173879 SPBio_000075 CC(=CCc1c2OC(C)(C)C=Cc2c(OC(=O)C)c3c(=O)c(OC(=O)C)c(oc13)c4ccccc4)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D18 compound treatment 9.6118091E7 -1.39E7 -0.8 9.0445805E7 -1.63E7 -1.0 -1.2722 -0.9935 2060154 SPBio_000076 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D19 compound treatment 5.1743133E7 -5.83E7 -3.33 4.976599E7 -5.69E7 -3.51 -4.8386 -0.9997 3054809 SPBio_000077 COc1ccc2C(=O)C(Cc3ccc(OC)c(OC(=O)C)c3)COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D20 compound treatment 8.8124446E7 -2.19E7 -1.25 8.6713908E7 -2.0E7 -1.23 -1.7579 -1.0 2060037 SPBio_000078 CC(=O)O[C@@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D21 compound treatment 9.2524584E7 -1.75E7 -1.0 8.8498304E7 -1.82E7 -1.12 -1.5023 -0.9984 2060139 SPBio_000079 COc1ccc([C@@H]2COc3c(OC)c(OC)ccc3C2)c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D22 compound treatment 9.8293418E7 -1.18E7 -0.67 9.9072546E7 -7640000.0 -0.47 -0.8082 -0.9849 2060350 SPBio_000080 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D23 mock treatment 1.02050686E8 -8000000.0 -0.46 1.02250327E8 -4460000.0 -0.28 -0.5179 -0.9705 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 D24 mock treatment 1.13742306E8 3690000.0 0.21 1.164588E8 9740000.0 0.6 0.5739 0.9015 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E01 mock treatment 1.01237719E8 -8810000.0 -0.5 1.01436392E8 -5280000.0 -0.33 -0.5862 -0.9777 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E02 mock treatment 1.00567264E8 -9480000.0 -0.54 9.9411837E7 -7300000.0 -0.45 -0.7016 -0.9957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E03 compound treatment 1.07861328E8 -2190000.0 -0.13 1.07085259E8 370000.0 0.02 -0.0723 -0.5687 1014792 SPBio_000081 OC(=O)c1cc2ccccc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E04 compound treatment 7.7464715E7 -3.26E7 -1.86 8.2210647E7 -2.45E7 -1.51 -2.3849 -0.9946 1365 SPBio_000082 CN(C)CCC=C1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E05 compound treatment 9.5842087E7 -1.42E7 -0.81 9.1893062E7 -1.48E7 -0.91 -1.2202 -0.9983 3173210 SPBio_000083 CO/N=C(\C(=O)NC1[C@H]2SCC(=C(N2C1=O)C(=O)O)CSc3nc(=O)c(=O)[nH]n3C)/c4csc(N)n4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E06 compound treatment 9.172751E7 -1.83E7 -1.05 9.1492062E7 -1.52E7 -0.94 -1.404 -0.9985 3173722 SPBio_000084 NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)C3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E07 compound treatment 9.2018408E7 -1.8E7 -1.03 8.7879909E7 -1.88E7 -1.16 -1.5497 -0.9982 1310 SPBio_000085 NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H]([C@H](OP(=O)(O)O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E08 compound treatment 9.3863158E7 -1.62E7 -0.93 9.2716818E7 -1.4E7 -0.86 -1.2643 -0.9994 712 SPBio_000086 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSc3ccncc3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E09 compound treatment 2.8222496E7 -8.18E7 -4.68 2.7807932E7 -7.89E7 -4.86 -6.7462 -0.9998 1010201 SPBio_000087 ClC1=C(Cl)C(=O)C(=C(Cl)C1=O)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E10 compound treatment 8.6054331E7 -2.4E7 -1.37 8.7455862E7 -1.93E7 -1.19 -1.8092 -0.9974 679 SPBio_000088 CC(=O)Nc1cc(ccc1O)[As](=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E11 compound treatment 2.8398331E7 -8.17E7 -4.67 2.7976794E7 -7.87E7 -4.85 -6.7318 -0.9998 193 SPBio_000089 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E12 compound treatment 8.887344E7 -2.12E7 -1.21 8.5913291E7 -2.08E7 -1.28 -1.7625 -0.9996 995 SPBio_000090 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@@H]([C@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E13 compound treatment 8.5138444E7 -2.49E7 -1.42 8.2758232E7 -2.4E7 -1.48 -2.051 -0.9998 2801 SPBio_000091 CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E14 compound treatment 7.2205362E7 -3.78E7 -2.16 7.2010362E7 -3.47E7 -2.14 -3.0421 -1.0 1141 SPBio_000092 CN1C2CCC1CC(C2)OC(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E15 compound treatment 8.8643513E7 -2.14E7 -1.22 8.4132688E7 -2.26E7 -1.39 -1.8494 -0.9979 3199906 SPBio_000093 CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(=C/[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E16 compound treatment 9.4034895E7 -1.6E7 -0.92 9.131783E7 -1.54E7 -0.95 -1.3183 -0.9998 735 SPBio_000094 NNC(=O)c1ccncc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E17 compound treatment 9.4569312E7 -1.55E7 -0.88 9.1838985E7 -1.49E7 -0.92 -1.274 -0.9998 2069298 SPBio_000095 CC(=O)Nc1c(I)cc(I)c(C(=O)O)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E18 compound treatment 1.02064193E8 -7990000.0 -0.46 9.1774574E7 -1.49E7 -0.92 -0.974 -0.9476 1519 SPBio_000096 CC1(C)OC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E19 compound treatment 9.0124617E7 -1.99E7 -1.14 9.1058592E7 -1.57E7 -0.97 -1.4877 -0.9966 3173493 SPBio_000097 CC1=C2CCC3C4CCC(=O)[C@@]4(C)CCC3[C@@]2(C)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E20 compound treatment 9.8196036E7 -1.19E7 -0.68 9.3890917E7 -1.28E7 -0.79 -1.038 -0.997 1414 SPBio_000098 CC(=O)NO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E21 compound treatment 1.06524535E8 -3530000.0 -0.2 1.02851829E8 -3860000.0 -0.24 -0.3109 -0.9965 1467 SPBio_000099 CCCCOc1ccc(OCCCN2CCOCC2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E22 compound treatment 9.5542874E7 -1.45E7 -0.83 9.0533547E7 -1.62E7 -1.0 -1.2916 -0.9958 1035 SPBio_000100 Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E23 mock treatment 1.08058442E8 -1990000.0 -0.11 1.03606612E8 -3110000.0 -0.19 -0.216 -0.9691 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 E24 mock treatment 1.13681467E8 3630000.0 0.21 1.08201808E8 1490000.0 0.09 0.2116 0.9325 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F01 mock treatment 1.12211337E8 2160000.0 0.12 1.02534881E8 -4180000.0 -0.26 -0.0949 -0.332 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F02 mock treatment 1.08357401E8 -1690000.0 -0.1 1.05019002E8 -1700000.0 -0.1 -0.1423 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F03 compound treatment 5.6443047E7 -5.36E7 -3.06 5.3431348E7 -5.33E7 -3.28 -4.4889 -0.9994 3173749 SPBio_000101 COc1cc2OC[C@H]3Oc4c5CC(Oc5ccc4C(=O)[C@H]3c2cc1OC)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F04 compound treatment 8.7967861E7 -2.21E7 -1.26 8.4460532E7 -2.23E7 -1.37 -1.8624 -0.9991 2060160 SPBio_000102 CC(=O)O[C@@H]1CC2C(C)(C)CCC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F05 compound treatment 9.705872E7 -1.3E7 -0.74 9.2837456E7 -1.39E7 -0.86 -1.1299 -0.9975 1008719 SPBio_000103 COC(=O)C(O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F06 compound treatment 8.6006408E7 -2.4E7 -1.37 8.2822102E7 -2.39E7 -1.47 -2.0131 -0.9994 2060129 SPBio_000104 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F07 compound treatment 8.9668002E7 -2.04E7 -1.16 8.4228908E7 -2.25E7 -1.39 -1.8038 -0.9963 2060163 SPBio_000105 COc1ccc2C(=O)[C@@H]3[C@@H](COc4cc(OC)c(OC)cc34)Oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F08 compound treatment 8.792917E7 -2.21E7 -1.26 8.9011387E7 -1.77E7 -1.09 -1.6656 -0.9973 2060365 SPBio_000106 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C3OC3[C@]2(C)C4CC[C@@]5(C)[C@@H](OC(=O)C6OC65[C@]14C)c7ccoc7 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F09 compound treatment 8.8333982E7 -2.17E7 -1.24 8.4955337E7 -2.18E7 -1.34 -1.8261 -0.9992 2060165 SPBio_000107 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F10 compound treatment 8.2659043E7 -2.74E7 -1.57 8.7433954E7 -1.93E7 -1.19 -1.9474 -0.9908 2060162 SPBio_000108 COC(=O)C[C@H]1C(C)(C)[C@@H](O)[C@@H]2CC3=C4C=C(OC)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F11 compound treatment 8.95304E7 -2.05E7 -1.17 8.806138E7 -1.87E7 -1.15 -1.6423 -1.0 1372522 SPBio_000109 COc1ccc(cc1)c2coc3cc(OC)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F12 compound treatment 8.3478918E7 -2.66E7 -1.52 8.4679077E7 -2.2E7 -1.36 -2.0343 -0.9985 2060177 SPBio_000110 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]2(C)[C@H]7O[C@H]7C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F13 compound treatment 8.7487828E7 -2.26E7 -1.29 8.5950511E7 -2.08E7 -1.28 -1.8169 -1.0 2069309 SPBio_000111 COc1cc2OC[C@H]3Oc4c5CCC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F14 compound treatment 8.7896448E7 -2.22E7 -1.27 8.2150018E7 -2.46E7 -1.51 -1.966 -0.996 2060320 SPBio_000112 COc1ccc2CC[C@@H]3CC(=O)CC[C@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F15 compound treatment 9.1385642E7 -1.87E7 -1.07 8.4710479E7 -2.2E7 -1.36 -1.7134 -0.9929 2060494 SPBio_000113 COc1ccc2C(=O)C(Cc3ccc(OC)c(OC)c3)COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F16 compound treatment 9.7323915E7 -1.27E7 -0.73 8.8432661E7 -1.83E7 -1.13 -1.3112 -0.9776 3173369 SPBio_000114 CC(C)c1c(OC(=O)C)ccc2c1CCC3C(C)(C)CCC[C@@]32C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F17 compound treatment 9.262869E7 -1.74E7 -1.0 8.8989143E7 -1.77E7 -1.09 -1.4767 -0.9989 2060110 SPBio_000115 COc1ccc(c(OC)c1)c2coc3cc(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F18 compound treatment 8.8004876E7 -2.2E7 -1.26 7.477026E7 -3.19E7 -1.97 -2.2833 -0.9767 2060034 SPBio_000116 CC(C)c1c(O)ccc2c1CCC3[C@](C)(CCC[C@@]32C)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F19 compound treatment 8.6071844E7 -2.4E7 -1.37 8.1648169E7 -2.51E7 -1.55 -2.0616 -0.9982 2060102 SPBio_000117 COc1ccc2C(=O)c3cc(OC)c(OC)cc3CC(=O)COc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F20 compound treatment 1.03488593E8 -6560000.0 -0.38 9.9120201E7 -7590000.0 -0.47 -0.5962 -0.994 2060126 SPBio_000118 CC(C)c1c(O)ccc2c1CCC3[C@@](C)(CO)CCC[C@@]32C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F21 compound treatment 1.0050477E8 -9550000.0 -0.55 9.8021588E7 -8690000.0 -0.54 -0.7647 -1.0 1059133 SPBio_000119 COc1ccc(C(=O)c2ccccc2)c(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F22 compound treatment 1.18519875E8 8470000.0 0.48 1.11591254E8 4880000.0 0.3 0.5548 0.9737 3053987 SPBio_000120 CC(=O)C1CC[C@H]2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F23 mock treatment 1.09923081E8 -127000.0 -0.01 1.02514941E8 -4200000.0 -0.26 -0.1882 -0.7267 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 F24 mock treatment 1.23994681E8 1.39E7 0.8 1.09924846E8 3210000.0 0.2 0.7034 0.8567 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G01 mock treatment 1.01255483E8 -8790000.0 -0.5 1.01659083E8 -5060000.0 -0.31 -0.5758 -0.9736 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G02 mock treatment 1.10914878E8 865000.0 0.05 1.02953702E8 -3760000.0 -0.23 -0.129 -0.5442 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G03 compound treatment 7.307939E7 -3.7E7 -2.11 8.0006411E7 -2.67E7 -1.65 -2.6582 -0.9924 2060144 SPBio_000121 COc1cccc(c1)c2cc(=O)c3cc(OC)ccc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G04 compound treatment 1.06694248E8 -3360000.0 -0.19 1.00332318E8 -6380000.0 -0.39 -0.4138 -0.9455 696 SPBio_000122 Oc1cccc2Cc3cccc(O)c3C(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G05 compound treatment 9.3960717E7 -1.61E7 -0.92 9.8362767E7 -8350000.0 -0.51 -1.0143 -0.9624 3077146 SPBio_000123 CN[C@@H]1[C@@H](O)C(OC2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)OC[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G06 compound treatment 9.7797454E7 -1.23E7 -0.7 1.01265778E8 -5450000.0 -0.34 -0.7327 -0.9434 1124 SPBio_000124 CN1C2CC[C@@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G07 compound treatment 9.3778289E7 -1.63E7 -0.93 9.433399E7 -1.24E7 -0.76 -1.1972 -0.9952 3077147 SPBio_000125 CC(O)Cn1c(C)ncc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G08 compound treatment 8.8713635E7 -2.13E7 -1.22 8.4704625E7 -2.2E7 -1.36 -1.8216 -0.9986 1247 SPBio_000126 Oc1c(Cl)cc(Cl)cc1Sc2cc(Cl)cc(Cl)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G09 compound treatment 8.7268843E7 -2.28E7 -1.3 8.9282974E7 -1.74E7 -1.07 -1.6805 -0.9955 1461079 SPBio_000127 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCN(C)CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G10 compound treatment 8.9052534E7 -2.1E7 -1.2 8.958561E7 -1.71E7 -1.06 -1.5952 -0.998 1327 SPBio_000128 C[N+](C)(C)CCOC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G11 compound treatment 1.01758792E8 -8290000.0 -0.47 1.03275735E8 -3440000.0 -0.21 -0.485 -0.9342 3480340 SPBio_000129 c1cn(cn1)C(c2ccccc2)c3ccc(cc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G12 compound treatment 8.6452787E7 -2.36E7 -1.35 8.3509438E7 -2.32E7 -1.43 -1.9651 -0.9996 1432 SPBio_000130 CN(C)CCOC(C)(c1ccccc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G13 compound treatment 9.044209E7 -1.96E7 -1.12 8.8149452E7 -1.86E7 -1.14 -1.6016 -0.9999 3199907 SPBio_000131 OC(=O)c1cn(c2ccc(F)cc2)c3cc(N4CCNCC4)c(F)cc3c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G14 compound treatment 9.4677803E7 -1.54E7 -0.88 9.4578696E7 -1.21E7 -0.75 -1.1502 -0.9968 873 SPBio_000132 Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CNc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G15 compound treatment 8.5402677E7 -2.46E7 -1.41 8.4289042E7 -2.24E7 -1.38 -1.9736 -1.0 1007083 SPBio_000133 Oc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G16 compound treatment 9.6026851E7 -1.4E7 -0.8 9.2713804E7 -1.4E7 -0.86 -1.177 -0.9993 1513 SPBio_000134 CCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G17 compound treatment 6.8056257E7 -4.2E7 -2.4 6.3836466E7 -4.29E7 -2.64 -3.5661 -0.9988 1008492 SPBio_000135 O=C(CC(=O)c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G18 compound treatment 9.9360663E7 -1.07E7 -0.61 9.579246E7 -1.09E7 -0.67 -0.9081 -0.9988 1000042 SPBio_000136 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G19 compound treatment 1.01792086E8 -8260000.0 -0.47 9.7010303E7 -9700000.0 -0.6 -0.7567 -0.9931 3480338 SPBio_000137 OC(=O)C(Cc1cc(=O)[nH]c2ccccc12)NC(=O)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G20 compound treatment 9.558319E7 -1.45E7 -0.83 9.4450706E7 -1.23E7 -0.76 -1.1192 -0.999 3172713 SPBio_000138 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C)\c3csc(N)n3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G21 compound treatment 4.4763028E7 -6.53E7 -3.73 4.5655073E7 -6.11E7 -3.76 -5.2999 -1.0 903 SPBio_000139 COC(=O)Nc1nc2ccc(Sc3ccccc3)cc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G22 compound treatment 1.11260528E8 1210000.0 0.07 1.03636098E8 -3080000.0 -0.19 -0.0853 -0.4222 1336 SPBio_000140 CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G23 mock treatment 1.03739941E8 -6310000.0 -0.36 1.03977741E8 -2740000.0 -0.17 -0.3743 -0.9401 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 G24 mock treatment 1.24174753E8 1.41E7 0.81 1.14575908E8 7860000.0 0.48 0.9134 0.9702 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H01 mock treatment 1.00777236E8 -9270000.0 -0.53 1.0019543E8 -6520000.0 -0.4 -0.6589 -0.9907 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H02 mock treatment 1.01023767E8 -9030000.0 -0.52 9.5537791E7 -1.12E7 -0.69 -0.852 -0.9898 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H03 compound treatment 9.673568E7 -1.33E7 -0.76 9.7607054E7 -9110000.0 -0.56 -0.9351 -0.9888 2060106 SPBio_000141 COc1cc(cc(OC)c1OC)c2coc3cc(OC)c(OC)c(OC)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H04 compound treatment 5.5873977E7 -5.42E7 -3.1 7.3651277E7 -3.31E7 -2.04 -3.6306 -0.9794 3173992 SPBio_000142 CC(C)c1c(O)ccc2c1CCC3C(C)(C)CCC[C@@]32C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H05 compound treatment 7.1478159E7 -3.86E7 -2.2 6.1383245E7 -4.53E7 -2.79 -3.5347 -0.9931 3054981 SPBio_000143 COc1ccc(cc1)c2cc(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H06 compound treatment 9.5403471E7 -1.46E7 -0.84 9.660503E7 -1.01E7 -0.62 -1.0326 -0.9894 2060280 SPBio_000144 C[C@H]1C2C(CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4CC[C@]23C)OC(=O)C)O[C@]61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H07 compound treatment 8.9110508E7 -2.09E7 -1.2 8.7314701E7 -1.94E7 -1.2 -1.6918 -1.0 3054030 SPBio_000145 Oc1cc(O)cc(/C=C/c2ccccc2)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H08 compound treatment 9.7667784E7 -1.24E7 -0.71 9.3100552E7 -1.36E7 -0.84 -1.0938 -0.9964 3174366 SPBio_000146 C[C@H]1C2C(CC3C4CC[C@@H]5C[C@H](CC[C@]5(C)C4CC[C@]23C)OC(=O)C)O[C@]61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H09 compound treatment 8.8131703E7 -2.19E7 -1.25 8.7821101E7 -1.89E7 -1.16 -1.7093 -0.9993 3055207 SPBio_000147 COc1cc(O)cc(/C=C/c2ccccc2)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H10 compound treatment 9.4606249E7 -1.54E7 -0.88 9.6527284E7 -1.02E7 -0.63 -1.0682 -0.9861 2060351 SPBio_000148 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4=CC(=O)[C@]23C)OC(=O)C)OC61OCC(C)CC6Br 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H11 compound treatment 7.1019482E7 -3.9E7 -2.23 6.8726873E7 -3.8E7 -2.34 -3.2331 -0.9997 3054032 SPBio_000149 COc1cc(C/C=C/c2ccccc2)c(OC)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H12 compound treatment 8.8803461E7 -2.12E7 -1.21 8.7465273E7 -1.92E7 -1.19 -1.6977 -0.9999 2060188 SPBio_000150 C[C@H]1C2C(CC3C4CCC5C[C@@H](O)CCC5(C)C4=CCC23C)OC61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H13 compound treatment 9.2581618E7 -1.75E7 -1.0 9.0530181E7 -1.62E7 -1.0 -1.4114 -1.0 2060259 SPBio_000151 COc1ccc2c(=O)c(CC(=O)O)coc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H14 compound treatment 9.5621478E7 -1.44E7 -0.82 9.4392221E7 -1.23E7 -0.76 -1.1202 -0.9992 3173999 SPBio_000152 C[C@H]1C2C(CC3C4CC[C@H]5CC(CCC5(C)C4CC(=O)C23C)OC(=O)C)OC61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H15 compound treatment 5.0587443E7 -5.95E7 -3.4 4.7474754E7 -5.92E7 -3.65 -4.9852 -0.9994 2060294 SPBio_000153 COc1ccc2C(=O)C(Cc3ccc(OC)c(O)c3)COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H16 compound treatment 9.5104939E7 -1.49E7 -0.85 9.2832492E7 -1.39E7 -0.86 -1.2091 -1.0 3054097 SPBio_000154 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H17 compound treatment 9.6267261E7 -1.38E7 -0.79 9.543804E7 -1.13E7 -0.7 -1.0485 -0.9981 2060133 SPBio_000155 COc1cc(cc(O)c1OC)c2coc3cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(O)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H18 compound treatment 4.6581733E7 -6.35E7 -3.63 4.5185011E7 -6.15E7 -3.79 -5.2469 -0.9998 3173995 SPBio_000156 C[C@H]1C2C(O[C@@]31CC[C@@H](C)CO3)C(O)C4C5CC[C@H]6C[C@H](O[C@@H]7O[C@H](CO)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@H]8O[C@@H]%10O[C@H](CO)[C@H](O)[C@H](O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%11O)[C@H]%10O)[C@H](O)[C@H]7O)[C@H](O)C[C@]6(C)C5CC[C@]24C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H19 compound treatment 1.04057209E8 -5990000.0 -0.34 1.00791924E8 -5920000.0 -0.37 -0.5004 -0.9995 3054129 SPBio_000157 CO[C@@H]1CC2N3CC(O)C2(C=C1)c4cc5OCOc5c(OC)c4C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H20 compound treatment 9.7261889E7 -1.28E7 -0.73 9.2905961E7 -1.38E7 -0.85 -1.1187 -0.9971 1355 SPBio_000158 CC(C)(O)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@@]53C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H21 compound treatment 9.3291751E7 -1.68E7 -0.96 9.3841771E7 -1.29E7 -0.79 -1.2384 -0.9956 2060069 SPBio_000159 COc1cc(cc(O)c1OC)c2coc3cc(OCc4ccccc4)c(OC)c(O)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H22 compound treatment 9.5055768E7 -1.5E7 -0.86 9.2945834E7 -1.38E7 -0.85 -1.2061 -1.0 2060207 SPBio_000160 CC1(C)[C@H](O)C[C@H](O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H23 mock treatment 1.06782607E8 -3270000.0 -0.19 1.05869976E8 -845000.0 -0.05 -0.1689 -0.8711 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 H24 mock treatment 1.17079157E8 7030000.0 0.4 1.06267894E8 -447000.0 -0.03 0.2646 0.6571 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I01 mock treatment 1.02718114E8 -7330000.0 -0.42 1.03778429E8 -2940000.0 -0.18 -0.4243 -0.9295 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I02 mock treatment 1.01902355E8 -8150000.0 -0.47 1.10437281E8 3720000.0 0.23 -0.167 -0.3217 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I03 compound treatment 9.5046923E7 -1.5E7 -0.86 9.626107E7 -1.05E7 -0.64 -1.062 -0.9901 2060260 SPBio_000161 COc1ccc(cc1)C2CC(=O)c3ccc(OC)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I04 compound treatment 9.7843442E7 -1.22E7 -0.7 1.04623102E8 -2090000.0 -0.13 -0.5845 -0.8238 759 SPBio_000162 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I05 compound treatment 9.6637161E7 -1.34E7 -0.77 9.8624039E7 -8090000.0 -0.5 -0.8947 -0.9783 2335 SPBio_000163 COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I06 compound treatment 9.4909073E7 -1.51E7 -0.87 9.5149754E7 -1.16E7 -0.71 -1.116 -0.9954 807 SPBio_000164 CCCc1ncc(C[n+]2ccccc2C)c(N)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I07 compound treatment 9.4819621E7 -1.52E7 -0.87 9.6934192E7 -9780000.0 -0.6 -1.0418 -0.9839 1025940 SPBio_000165 Cc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I08 compound treatment 9.3987345E7 -1.61E7 -0.92 9.4413335E7 -1.23E7 -0.76 -1.1853 -0.9955 1381 SPBio_000166 Nc1ccc(cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I09 compound treatment 8.7665888E7 -2.24E7 -1.28 8.4810372E7 -2.19E7 -1.35 -1.8594 -0.9996 2516 SPBio_000167 CC(C)OC(=O)Nc1cccc(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I10 compound treatment 9.1309196E7 -1.87E7 -1.07 8.9382994E7 -1.73E7 -1.07 -1.5128 -1.0 1303 SPBio_000168 C[N+]1(CCC2CC1)CC2OC(=O)C(O)(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I11 compound treatment 9.6751695E7 -1.33E7 -0.76 9.8884384E7 -7830000.0 -0.48 -0.8787 -0.976 2069315 SPBio_000169 COc1cc(OC)c2c(=O)c(coc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I12 compound treatment 8.8728992E7 -2.13E7 -1.22 8.959346E7 -1.71E7 -1.06 -1.6079 -0.9974 1019 SPBio_000170 NC(=O)N1c2ccccc2C=Cc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I13 compound treatment 8.434387E7 -2.57E7 -1.47 8.4336311E7 -2.24E7 -1.38 -2.0143 -0.9995 2060112 SPBio_000171 COc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I14 compound treatment 9.3676296E7 -1.64E7 -0.94 9.4319209E7 -1.24E7 -0.76 -1.202 -0.9949 1400 SPBio_000172 CC(C)[C@@H](C)/C=C/[C@@H](C)C1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)CCC3=C)\CCC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I15 compound treatment 9.8981445E7 -1.11E7 -0.63 9.4512284E7 -1.22E7 -0.75 -0.9792 -0.9963 1602 SPBio_000173 COc1ccc(cc1)c2coc3cc(O)cc(O)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I16 compound treatment 9.3778905E7 -1.63E7 -0.93 9.4678496E7 -1.2E7 -0.74 -1.1822 -0.9937 1000114 SPBio_000174 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I17 compound treatment 6.1696106E7 -4.84E7 -2.76 5.131504E7 -5.54E7 -3.41 -4.3689 -0.9945 2069308 SPBio_000175 CC(=CCc1c(O)cc2occ(c3ccc4OCOc4c3)c(=O)c2c1O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I18 compound treatment 8.5807164E7 -2.42E7 -1.39 8.2488174E7 -2.42E7 -1.49 -2.0357 -0.9993 1272 SPBio_000176 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I19 compound treatment 1.0069444E8 -9360000.0 -0.53 9.6863395E7 -9850000.0 -0.61 -0.8075 -0.998 1534 SPBio_000177 O=C(/C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I20 compound treatment 1.00011222E8 -1.0E7 -0.57 9.4010204E7 -1.27E7 -0.78 -0.9595 -0.9883 1000138 SPBio_000178 CC(C)Cc1ccc(cc1)C(C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I21 compound treatment 9.5570822E7 -1.45E7 -0.83 9.4360643E7 -1.24E7 -0.76 -1.1236 -0.9991 2060354 SPBio_000179 COc1ccc(cc1)c2coc3cc(OC(=O)C)cc(OC(=O)C)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I22 compound treatment 9.6059977E7 -1.4E7 -0.8 1.02019953E8 -4690000.0 -0.29 -0.77 -0.9056 1157 SPBio_000180 CC(=O)N1CCN(CC1)c2ccc(OCC3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I23 mock treatment 1.01185425E8 -8860000.0 -0.51 1.06027483E8 -687000.0 -0.04 -0.3882 -0.7636 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 I24 mock treatment 1.16258122E8 6210000.0 0.35 1.14259774E8 7540000.0 0.47 0.5797 0.9911 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J01 mock treatment 1.03755151E8 -6300000.0 -0.36 1.0515964E8 -1560000.0 -0.1 -0.3222 -0.8653 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J02 mock treatment 1.09558808E8 -491000.0 -0.03 1.06201666E8 -513000.0 -0.03 -0.0422 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J03 compound treatment 9.5211202E7 -1.48E7 -0.85 9.0582938E7 -1.61E7 -0.99 -1.3028 -0.9969 2120750 SPBio_000181 CC(C)C(C)/C=C/C(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J04 compound treatment 1.02578742E8 -7470000.0 -0.43 9.4828672E7 -1.19E7 -0.73 -0.82 -0.967 2060212 SPBio_000182 CC1(C)[C@H](O)CC(=O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J05 compound treatment 9.5713046E7 -1.43E7 -0.82 9.298987E7 -1.37E7 -0.85 -1.1776 -0.9999 2060070 SPBio_000183 COc1c(O)cc(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J06 compound treatment 3.8430388E7 -7.16E7 -4.09 3.7223727E7 -6.95E7 -4.28 -5.9233 -0.9997 3054128 SPBio_000184 COC1C[C@H]2N3CC(O)C2(C=C1)c4cc5OCOc5cc4C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J07 compound treatment 3.9254434E7 -7.08E7 -4.05 4.8063617E7 -5.87E7 -3.62 -5.4175 -0.9984 3177381 SPBio_000185 Oc1ccc(cc1)C(=O)/C=C/c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J08 compound treatment 8.6762291E7 -2.33E7 -1.33 8.2708905E7 -2.4E7 -1.48 -1.9875 -0.9986 2060036 SPBio_000186 CC1=CCc2c(O)c3c(=O)cc(C)oc3cc2OC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J09 compound treatment 8.4264957E7 -2.58E7 -1.47 8.4313811E7 -2.24E7 -1.38 -2.0185 -0.9995 2060263 SPBio_000187 COc1ccc(C(=O)c2ccc(O)cc2)c(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J10 compound treatment 8.799385E7 -2.21E7 -1.26 8.4565075E7 -2.21E7 -1.37 -1.8568 -0.9992 2060187 SPBio_000188 COc1cccc(/C=C/C(=O)O)c1C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J11 compound treatment 9.1414266E7 -1.86E7 -1.07 9.0506825E7 -1.62E7 -1.0 -1.4596 -0.9995 1032994 SPBio_000189 O=C1CC(Oc2ccccc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J12 compound treatment 8.3053308E7 -2.7E7 -1.54 8.3452818E7 -2.33E7 -1.43 -2.105 -0.9993 2060117 SPBio_000190 Cc1ccc2c(CC[C@H]3CC(=O)CC[C@@]32C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J13 compound treatment 8.4957939E7 -2.51E7 -1.43 8.5347613E7 -2.14E7 -1.32 -1.9454 -0.9991 2060208 SPBio_000191 COC(=O)C[C@H]1C(C)(C)[C@@H](O)[C@@H]2CC3=C4CC(O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J14 compound treatment 8.9690185E7 -2.04E7 -1.16 9.038665E7 -1.63E7 -1.01 -1.5345 -0.9974 2060158 SPBio_000192 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](OC(=O)C)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J15 compound treatment 9.5255863E7 -1.48E7 -0.85 9.5885008E7 -1.08E7 -0.67 -1.0699 -0.9932 3058620 SPBio_000193 O[C@@H](C(=O)O)[C@@](O)(Cc1ccc(O)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J16 compound treatment 9.5700973E7 -1.43E7 -0.82 9.3387403E7 -1.33E7 -0.82 -1.1608 -1.0 2060153 SPBio_000194 COc1cccc2c1CCC3=CC(=O)CC[C@@]32C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J17 compound treatment 9.6713968E7 -1.33E7 -0.76 9.351812E7 -1.32E7 -0.81 -1.1142 -0.9995 2060238 SPBio_000195 Cc1cc(O)cc(O)c1C(=O)Oc2cc(C)c(C(=O)Oc3cc(C)c(C(=O)O)c(O)c3)c(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J18 compound treatment 6.0260276E7 -4.98E7 -2.85 6.053263E7 -4.62E7 -2.85 -4.0251 -1.0 3173991 SPBio_000196 C[C@@]12CCC3C(CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)C[C@H](O)[C@@H]1C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J19 compound treatment 6.4080837E7 -4.6E7 -2.63 6.1096076E7 -4.56E7 -2.81 -3.8462 -0.9994 2060216 SPBio_000197 COc1cc2OC[C@H]3Oc4c(ccc5oc(cc45)C(C)C)C(=O)[C@H]3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J20 compound treatment 4.9869958E7 -6.02E7 -3.44 5.8488593E7 -4.82E7 -2.97 -4.5341 -0.9974 2060214 SPBio_000198 COc1c(ccc2OC(C)(C)C=Cc12)c3coc4cc5OC(C)(C)C(O)Cc5cc4c3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J21 compound treatment 1.02769733E8 -7280000.0 -0.42 1.00943382E8 -5770000.0 -0.36 -0.5458 -0.997 2060242 SPBio_000199 COc1ccc(cc1)c2cc(=O)c3c(O)c(OC)c(O[C@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J22 compound treatment 4.9280247E7 -6.08E7 -3.47 4.7079578E7 -5.96E7 -3.68 -5.0552 -0.9996 3077173 SPBio_000200 CCOc1ccc(cc1)C(=O)c2ccc(OC)c(O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J23 mock treatment 1.14747019E8 4700000.0 0.27 1.10772376E8 4060000.0 0.25 0.3667 0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 J24 mock treatment 1.16549112E8 6500000.0 0.37 1.12724944E8 6010000.0 0.37 0.5246 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K01 mock treatment 1.03768838E8 -6280000.0 -0.36 1.07441529E8 727000.0 0.04 -0.2222 -0.6141 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K02 mock treatment 1.06261894E8 -3790000.0 -0.22 1.01676811E8 -5040000.0 -0.31 -0.3727 -0.9844 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K03 compound treatment 1.04262544E8 -5790000.0 -0.33 9.4394897E7 -1.23E7 -0.76 -0.7709 -0.9306 1403 SPBio_000201 COC(=O)C1=CCCN(C)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K04 compound treatment 1.07333937E8 -2720000.0 -0.16 1.00370662E8 -6340000.0 -0.39 -0.3863 -0.9181 1167 SPBio_000202 NCCCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K05 compound treatment 1.00193111E8 -9860000.0 -0.56 9.8414598E7 -8300000.0 -0.51 -0.7601 -0.9988 1013706 SPBio_000203 O=c1c2ccccc2oc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K06 compound treatment 9.4663486E7 -1.54E7 -0.88 9.4689087E7 -1.2E7 -0.74 -1.146 -0.9964 834 SPBio_000204 CC(C[N+](C)(C)C)OC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K07 compound treatment 9.2726637E7 -1.73E7 -0.99 9.3730661E7 -1.3E7 -0.8 -1.266 -0.9944 592 SPBio_000205 Oc1ccc(cc1)c2coc3cc(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K08 compound treatment 9.8782387E7 -1.13E7 -0.64 1.01879042E8 -4840000.0 -0.3 -0.6661 -0.9387 1059 SPBio_000206 CN(C)CC/C=C\1/c2ccccc2COc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K09 compound treatment 3.0369635E7 -7.97E7 -4.55 2.9097916E7 -7.76E7 -4.78 -6.6032 -0.9997 2069329 SPBio_000207 COc1cc(O)c2c(=O)cc(oc2c1)c3ccc(OC)c(c3)c4c(O)cc(O)c5c(=O)cc(oc45)c6ccc(O)cc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K10 compound treatment 3.114827E7 -7.89E7 -4.51 2.7890041E7 -7.88E7 -4.86 -6.6244 -0.9993 1373 SPBio_000208 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K11 compound treatment 9.2157044E7 -1.79E7 -1.02 9.4257104E7 -1.25E7 -0.77 -1.2661 -0.99 2069249 SPBio_000209 COc1ccc(cc1)c2coc3c(O)c(OC)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K12 compound treatment 9.0111456E7 -1.99E7 -1.14 8.4551753E7 -2.22E7 -1.37 -1.7718 -0.9959 1360 SPBio_000210 Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K13 compound treatment 1.12286772E8 2240000.0 0.13 1.11156515E8 4440000.0 0.27 0.284 0.9398 1250 SPBio_000211 COc1cc(C)c2c(=O)cc(oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K14 compound treatment 9.1494775E7 -1.86E7 -1.06 9.2500909E7 -1.42E7 -0.88 -1.3694 -0.9955 1396 SPBio_000212 Cc1cc(O)cc(C)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K15 compound treatment 7.7581053E7 -3.25E7 -1.86 7.9638774E7 -2.71E7 -1.67 -2.4923 -0.9986 1672652 SPBio_000213 COc1ccc(cc1)c2cc(=O)c3ccc(OC)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K16 compound treatment 9.7274225E7 -1.28E7 -0.73 9.3885519E7 -1.28E7 -0.79 -1.0755 -0.9992 2069266 SPBio_000214 CNC(C)[C@H](O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K17 compound treatment 9.8123635E7 -1.19E7 -0.68 9.4507399E7 -1.22E7 -0.75 -1.0141 -0.9988 2069226 SPBio_000215 COc1ccc2-c3oc4cc(OC)ccc4c3COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K18 compound treatment 1.00322885E8 -9730000.0 -0.56 9.9159984E7 -7550000.0 -0.47 -0.7224 -0.9961 1445 SPBio_000216 C/C=C(/C)\C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@@H]4[C@@]2(C[C@@]5(O)[C@@H]6CN7C[C@@H](C)CC[C@H]7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]45O)O[C@@]31O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K19 compound treatment 6.0475776E7 -4.96E7 -2.83 5.6847365E7 -4.99E7 -3.07 -4.177 -0.9992 353 SPBio_000217 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K20 compound treatment 5.373217E7 -5.63E7 -3.22 4.8342089E7 -5.84E7 -3.6 -4.8203 -0.9985 1476 SPBio_000218 CNCCCC1(CCC2c3ccccc31)c4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K21 compound treatment 7.6466466E7 -3.36E7 -1.92 7.3709502E7 -3.3E7 -2.03 -2.7958 -0.9996 1116 SPBio_000219 S=c1[nH]cnc2nc[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K22 compound treatment 3.158519E7 -7.85E7 -4.48 3.4883721E7 -7.18E7 -4.43 -6.3019 -1.0 1095 SPBio_000220 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K23 mock treatment 1.0362712E8 -6420000.0 -0.37 1.01634878E8 -5080000.0 -0.31 -0.481 -0.9969 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 K24 mock treatment 1.14024348E8 3970000.0 0.23 1.14013466E8 7300000.0 0.45 0.4787 0.9499 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L01 mock treatment 1.10452191E8 402000.0 0.02 1.00131448E8 -6580000.0 -0.41 -0.2707 -0.666 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L02 mock treatment 9.2437359E7 -1.76E7 -1.01 9.6298386E7 -1.04E7 -0.64 -1.1658 -0.9764 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L03 compound treatment 1.07330917E8 -2720000.0 -0.16 1.05480072E8 -1230000.0 -0.08 -0.1637 -0.9461 1090422 SPBio_000221 Cc1cc(O)cc(O)c1C(=O)Oc2cc(C)c(C(=O)O)c(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L04 compound treatment 8.0643625E7 -2.94E7 -1.68 7.6342819E7 -3.04E7 -1.87 -2.5122 -0.9985 3077174 SPBio_000222 CC(=O)Oc1ccc(cc1)c2cc(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L05 compound treatment 1.02074201E8 -7980000.0 -0.46 1.02254844E8 -4460000.0 -0.27 -0.5167 -0.9707 2060043 SPBio_000223 COc1cc(OC)c(Cl)c2OC3(C(C)CC(=O)C=C3O)C(=O)c21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L06 compound treatment 4.5776117E7 -6.43E7 -3.67 4.2663674E7 -6.41E7 -3.95 -5.3893 -0.9994 3077175 SPBio_000224 COc1ccc2C(=O)/C(=C\c3ccc(O)c(O)c3)/COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L07 compound treatment 7.0603281E7 -3.94E7 -2.25 6.6809284E7 -3.99E7 -2.46 -3.3335 -0.9991 812 SPBio_000225 COC1=CC(=O)C[C@@H](C)[C@@]21Oc3c(C2=O)c(OC)cc(OC)c3Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L08 compound treatment 9.5716945E7 -1.43E7 -0.82 9.7650709E7 -9060000.0 -0.56 -0.9743 -0.9826 3054572 SPBio_000226 CC(=O)O[C@@H]1CC[C@@]2(C)C(CC[C@]3(C)C2CC=C4C5CC(C)(C)CC[C@@]5(CC[C@]43C)C(=O)O)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L09 compound treatment 9.5691603E7 -1.44E7 -0.82 9.7577948E7 -9140000.0 -0.56 -0.9785 -0.9831 1051460 SPBio_000227 COc1cc(C(=O)O)c2Oc3c(C=O)c(O)cc(C)c3C(=O)Oc2c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L10 compound treatment 9.4693119E7 -1.54E7 -0.88 9.559108E7 -1.11E7 -0.69 -1.1055 -0.9925 2060234 SPBio_000228 COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L11 compound treatment 9.4531215E7 -1.55E7 -0.89 9.3657499E7 -1.31E7 -0.8 -1.1963 -0.9988 2060040 SPBio_000229 CCOC(=O)C1(O)Oc2cc(OC)cc(OC)c2C(=O)C1c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L12 compound treatment 2.882326E7 -8.12E7 -4.64 2.7692076E7 -7.9E7 -4.87 -6.727 -0.9997 2069327 SPBio_000230 COC/1=CC(=O)C(=C\C1=C/C=C/c2ccccc2)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L13 compound treatment 5.9355657E7 -5.07E7 -2.9 4.6075027E7 -6.06E7 -3.74 -4.6918 -0.9921 2069243 SPBio_000231 O/C(=C\C(=O)c1ccccc1O)/c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L14 compound treatment 4.3220022E7 -6.68E7 -3.82 4.1195053E7 -6.55E7 -4.04 -5.5566 -0.9996 3173492 SPBio_000232 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(O)ccc3-c2c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L15 compound treatment 8.7268607E7 -2.28E7 -1.3 9.2118836E7 -1.46E7 -0.9 -1.5569 -0.9837 2060463 SPBio_000233 COc1ccc(cc1)c2coc3c(OC)c(OC)cc(O)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L16 compound treatment 2.8672434E7 -8.14E7 -4.65 2.7617821E7 -7.91E7 -4.88 -6.7363 -0.9997 2081025 SPBio_000234 C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L17 compound treatment 9.8730105E7 -1.13E7 -0.65 9.9462424E7 -7250000.0 -0.45 -0.7736 -0.9837 3172979 SPBio_000235 C[C@H]1C2C(CC3C4CC=C5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L18 compound treatment 8.9167257E7 -2.09E7 -1.19 8.2512305E7 -2.42E7 -1.49 -1.8989 -0.9939 3058525 SPBio_000236 COc1cc2OC[C@H]3Oc4c5C=CC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L19 compound treatment 1.01211674E8 -8840000.0 -0.51 1.01244032E8 -5470000.0 -0.34 -0.5956 -0.9807 923 SPBio_000237 NC(=O)NC1NC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L20 compound treatment 5.6386857E7 -5.37E7 -3.07 5.279818E7 -5.39E7 -3.32 -4.5188 -0.9992 3077176 SPBio_000238 COc1ccc(c(O)c1O)c2coc3cc(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L21 compound treatment 9.725111E7 -1.28E7 -0.73 9.7183049E7 -9530000.0 -0.59 -0.9327 -0.9941 3198310 SPBio_000239 COc1ccc([C@H]2COc3c(OC)c(O)ccc3C2)c(OC)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L22 compound treatment 3.5209658E7 -7.48E7 -4.28 3.3567042E7 -7.31E7 -4.51 -6.2128 -0.9997 3077177 SPBio_000240 CC(=O)OCC(O)CC(=O)CCCCCCCCCCCC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L23 mock treatment 1.02695168E8 -7360000.0 -0.42 1.02216583E8 -4500000.0 -0.28 -0.4933 -0.9796 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 L24 mock treatment 1.15059461E8 5010000.0 0.29 1.15189589E8 8470000.0 0.52 0.5718 0.9599 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M01 mock treatment 1.23103567E8 1.31E7 0.75 1.25910733E8 1.92E7 1.18 1.3642 0.9753 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M02 mock treatment 1.12856349E8 2810000.0 0.16 1.14552358E8 7840000.0 0.48 0.455 0.8939 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M03 compound treatment 1.11076485E8 1030000.0 0.06 1.01745597E8 -4970000.0 -0.31 -0.1751 -0.5615 3177464 SPBio_000241 NCCCC(N)CC(=O)NCC1NC(=O)C(CO)NC(=O)C(N)CNC(=O)C(NC(=O)/C(=C\NC(=O)N)/NC1=O)C2CCNC(=N)N2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M04 compound treatment 6.8763412E7 -4.13E7 -2.36 6.1681769E7 -4.5E7 -2.78 -3.6314 -0.9967 984 SPBio_000242 C[C@H]1CC2C3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)C2[C@@]4(C)CCC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M05 compound treatment 1.01070565E8 -8980000.0 -0.51 1.00584304E8 -6130000.0 -0.38 -0.6301 -0.9887 1149 SPBio_000243 CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M06 compound treatment 3.1701351E7 -7.83E7 -4.48 3.1107859E7 -7.56E7 -4.66 -6.4618 -0.9998 1011303 SPBio_000244 CN1CCc2cccc-3c2C1Cc4ccc(O)c(O)c43 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M07 compound treatment 6.1089282E7 -4.9E7 -2.8 6.0803756E7 -4.59E7 -2.83 -3.9798 -1.0 3173471 SPBio_000245 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M08 compound treatment 9.1206436E7 -1.88E7 -1.08 8.5717225E7 -2.1E7 -1.29 -1.6768 -0.9958 980 SPBio_000246 C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)[C@@]3(O)C(=C2C(=O)c4c(O)cccc14)O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M09 compound treatment 6.7738459E7 -4.23E7 -2.42 6.4915022E7 -4.18E7 -2.58 -3.5319 -0.9995 430 SPBio_000247 NC(=O)NO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M10 compound treatment 9.5020553E7 -1.5E7 -0.86 9.6845805E7 -9870000.0 -0.61 -1.0376 -0.9857 1481 SPBio_000248 Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc4ccccc14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M11 compound treatment 3.5015414E7 -7.5E7 -4.29 3.3381416E7 -7.33E7 -4.52 -6.2288 -0.9997 1295 SPBio_000249 OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M12 compound treatment 9.7927863E7 -1.21E7 -0.69 9.9298627E7 -7420000.0 -0.46 -0.8132 -0.9796 3045196 SPBio_000250 CC1(C)S[C@@H]2[C@H](NC(=O)[C@@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M13 compound treatment 2.9697461E7 -8.04E7 -4.59 2.8869797E7 -7.78E7 -4.8 -6.6403 -0.9998 892 SPBio_000251 C[n+]1c2cc(N)ccc2cc3ccc(N)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M14 compound treatment 3.5570781E7 -7.45E7 -4.26 3.4024735E7 -7.27E7 -4.48 -6.1783 -0.9997 1309 SPBio_000252 Cc1cc(C2CCCCC2)n(O)c(=O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M15 compound treatment 9.1856554E7 -1.82E7 -1.04 8.9916144E7 -1.68E7 -1.04 -1.4675 -1.0 1437 SPBio_000253 CS(=O)(=O)OCCCCOS(=O)(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M16 compound treatment 7.1496246E7 -3.86E7 -2.2 7.1457391E7 -3.53E7 -2.17 -3.0949 -1.0 1110 SPBio_000254 C[C@H]1CC2C3CC[C@](OC(=O)C)(C(=O)C)[C@@]3(C)CCC2[C@@]4(C)CCC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M17 compound treatment 8.0385571E7 -2.97E7 -1.7 7.7778547E7 -2.89E7 -1.78 -2.4601 -0.9997 1198 SPBio_000255 Cn1cnc([N+](=O)[O-])c1Sc2[nH]cnc3ncnc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M18 compound treatment 8.8499406E7 -2.16E7 -1.23 8.1724565E7 -2.5E7 -1.54 -1.9602 -0.9939 1138 SPBio_000256 CC/C(=C(/CC)\c1ccc(O)cc1)/c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M19 compound treatment 1.01464921E8 -8590000.0 -0.49 9.8163842E7 -8550000.0 -0.53 -0.7197 -0.9994 3174477 SPBio_000257 CN[C@H](CC(C)C)C(=O)NC1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6CC(=O)C(NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@@H](NC6=O)C(=O)O)c3O[C@@H]9OC(CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M20 compound treatment 9.9658341E7 -1.04E7 -0.59 9.6594138E7 -1.01E7 -0.62 -0.8611 -0.9997 982 SPBio_000258 CC(=O)Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M21 compound treatment 2.9777597E7 -8.03E7 -4.59 2.8371698E7 -7.83E7 -4.83 -6.6588 -0.9997 707 SPBio_000259 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CCC6C5CC[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M22 compound treatment 2.8835797E7 -8.12E7 -4.64 2.7783205E7 -7.89E7 -4.87 -6.7225 -0.9997 2114344 SPBio_000260 CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M23 mock treatment 1.05184494E8 -4870000.0 -0.28 1.04556388E8 -2160000.0 -0.13 -0.2907 -0.943 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 M24 mock treatment 1.22491035E8 1.24E7 0.71 1.15392183E8 8680000.0 0.53 0.881 0.9902 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N01 mock treatment 1.15878617E8 5830000.0 0.33 1.02576836E8 -4140000.0 -0.26 0.0552 0.1315 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N02 mock treatment 1.14495107E8 4440000.0 0.25 1.12046408E8 5330000.0 0.33 0.412 0.9919 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N03 compound treatment 1.11297686E8 1250000.0 0.07 9.929383E7 -7420000.0 -0.46 -0.2731 -0.5898 970 SPBio_000261 CC1(C)O[C@]2(C)CC[C@H]1CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N04 compound treatment 1.01157873E8 -8890000.0 -0.51 9.7318394E7 -9400000.0 -0.58 -0.7689 -0.9979 2060424 SPBio_000262 C[C@@]12CC[C@@H](O)C[C@H]2CCc3ccccc31 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N05 compound treatment 1.05331205E8 -4720000.0 -0.27 1.01139489E8 -5580000.0 -0.34 -0.4337 -0.9928 893 SPBio_000263 NCC(O)c1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N06 compound treatment 4.0449096E7 -6.96E7 -3.98 3.8938007E7 -6.78E7 -4.18 -5.767 -0.9997 2060300 SPBio_000264 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O)c(c4cc(ccc4OC)c5cc(=O)c6c(O)cc(O)cc6o5)c3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N07 compound treatment 9.4864498E7 -1.52E7 -0.87 9.1621979E7 -1.51E7 -0.93 -1.2716 -0.9994 2060025 SPBio_000265 CC(=O)O[C@H]1C[C@@]2(C)[C@@H](OC(=O)[C@H]3O[C@]32[C@]4(C)[C@@H](CC5C(C)(C)[C@@H](C[C@H](OC(=O)C)[C@]5(C)C14)OC(=O)C)OC(=O)C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N08 compound treatment 9.7051449E7 -1.3E7 -0.74 9.7644803E7 -9070000.0 -0.56 -0.9207 -0.9902 1010471 SPBio_000266 O=c1ccc2ccccc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N09 compound treatment 9.5738655E7 -1.43E7 -0.82 9.6204273E7 -1.05E7 -0.65 -1.0365 -0.9933 3173997 SPBio_000267 COC(=O)CC1C(C)(C)C(=O)C=CC1(C)C2CC[C@@]3(C)[C@@H](OC(=O)C4OC43C2=C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N10 compound treatment 2.8349936E7 -8.17E7 -4.67 2.7175931E7 -7.95E7 -4.9 -6.7686 -0.9997 2060107 SPBio_000268 COC1=C(OC)C(=O)C(=CC1=O)[C@H](C=C)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N11 compound treatment 2.8604438E7 -8.14E7 -4.65 2.7568273E7 -7.91E7 -4.88 -6.7412 -0.9997 3054122 SPBio_000269 CC(=O)O[C@@H]1C[C@@]2(C)[C@@H](C[C@H]3O[C@]32[C@@]4(C)C1[C@@]5(C)C=CC(=O)C(C)(C)C5=C(O)C4=O)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N12 compound treatment 9.592179E7 -1.41E7 -0.81 9.6305738E7 -1.04E7 -0.64 -1.0247 -0.9935 2060113 SPBio_000270 Cc1cc(O)cc(O)c1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N13 compound treatment 7.3571183E7 -3.65E7 -2.08 7.4633889E7 -3.21E7 -1.98 -2.8725 -0.9997 2060028 SPBio_000271 COC(=O)C[C@H]1C2(C)CC3(OC4(C)O[C@@]56[C@H](OC(=O)C)[C@@]3(O)C2OC(=O)C(C)C)[C@]1(C)[C@@]6(O4)[C@H](OC(=O)C)C(OC(=O)C)[C@@]7(C)[C@@H](OC(=O)/C(=C(\O)/C(C)C)/C57)c8ccoc8 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N14 compound treatment 8.7515741E7 -2.25E7 -1.29 3.6593728E7 -7.01E7 -4.32 -3.9671 -0.8796 2060136 SPBio_000272 CC(=C)c1cc2cc(C(=O)C)c(O)cc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N15 compound treatment 9.4148139E7 -1.59E7 -0.91 9.5613565E7 -1.11E7 -0.68 -1.1265 -0.9902 2060030 SPBio_000273 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3C(CC[C@@]4(C)[C@@H](OC(=O)C=C34)c5ccoc5)[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N16 compound treatment 9.866464E7 -1.14E7 -0.65 9.9637549E7 -7080000.0 -0.44 -0.7686 -0.9811 1049466 SPBio_000274 COc1cc(C)c2C(=O)Oc3c(C)c(O)c4C(=O)OC(O)c4c3Oc2c1C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N17 compound treatment 2.9690966E7 -8.04E7 -4.59 2.8422769E7 -7.83E7 -4.83 -6.6601 -0.9997 2060031 SPBio_000275 C[C@]12CCC3[C@@]4(C)C=CC(=O)C(C)(C)C4=C(O)C(=O)[C@@]3(C)[C@]25O[C@@H]5C[C@H]1c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N18 compound treatment 9.6055202E7 -1.4E7 -0.8 9.2280445E7 -1.44E7 -0.89 -1.1947 -0.9986 1086162 SPBio_000276 COc1c2ccoc2c(OC)c3oc(=O)ccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N19 compound treatment 9.1089517E7 -1.9E7 -1.08 8.9672619E7 -1.7E7 -1.05 -1.5091 -0.9999 2060035 SPBio_000277 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)[C@@]2(C)C=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N20 compound treatment 1.12329012E8 2280000.0 0.13 1.09549294E8 2830000.0 0.17 0.2156 0.9895 3077178 SPBio_000278 CC1CCC2(C)C(CCC=C2C)C1(C)CC/C(=C/Cn3c[n+](C)c4c(N)ncnc34)/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N21 compound treatment 1.00208586E8 -9840000.0 -0.56 9.6990897E7 -9720000.0 -0.6 -0.8216 -0.9995 2060230 SPBio_000279 CC(=O)O[C@H]1C[C@@H](O)C(C)(C)C2C[C@@H](OC(=O)C)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N22 compound treatment 1.10940184E8 890000.0 0.05 1.0185512E8 -4860000.0 -0.3 -0.1759 -0.5788 2069254 SPBio_000280 CCCCCc1c(C(=O)O)c(O)cc2OC(=O)c3c(cc(OC)cc3Oc12)C(=O)CCCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N23 mock treatment 1.03634457E8 -6420000.0 -0.37 1.0348206E8 -3230000.0 -0.2 -0.4002 -0.9589 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 N24 mock treatment 1.15317812E8 5270000.0 0.3 1.1545301E8 8740000.0 0.54 0.5938 0.9622 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O01 mock treatment 1.13036753E8 2990000.0 0.17 1.14979341E8 8260000.0 0.51 0.4809 0.8951 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O02 mock treatment 1.00085865E8 -9960000.0 -0.57 1.00865437E8 -5850000.0 -0.36 -0.6576 -0.9757 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O03 compound treatment 1.088338E8 -1220000.0 -0.07 9.9701919E7 -7010000.0 -0.43 -0.3548 -0.8104 3173595 SPBio_000281 C[C@H]1OC(OC/2CC3O[C@@](O)(CC(O)C3C(=O)O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)C(C)[C@H](O)[C@@H](C)/C=C/C=C/CC\C=C\C=C\C=C\C=C2)[C@@H](O)[C@@H](N)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O04 compound treatment 1.03118356E8 -6930000.0 -0.4 9.8673056E7 -8040000.0 -0.5 -0.6307 -0.9938 1002775 SPBio_000282 Cc1cccc(C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O05 compound treatment 4.2062792E7 -6.8E7 -3.89 3.4670165E7 -7.2E7 -4.44 -5.8878 -0.9978 1000036 SPBio_000283 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3C2C[C@@H]1CC4NCCc5cc(OC)c(OC)cc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O06 compound treatment 8.4200317E7 -2.58E7 -1.48 8.2697561E7 -2.4E7 -1.48 -2.0915 -1.0 3058740 SPBio_000284 CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CCC3C4CCC(=O)[C@@]4(C)CCC32)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O07 compound treatment 5.011113E7 -5.99E7 -3.43 4.9895095E7 -5.68E7 -3.5 -4.8989 -0.9999 1383 SPBio_000285 CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2OC3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O08 compound treatment 2.8486554E7 -8.16E7 -4.66 2.7572656E7 -7.91E7 -4.88 -6.7458 -0.9997 943 SPBio_000286 CCCCC1C(=O)N(N(C1=O)c2ccc(O)cc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O09 compound treatment 2.9368219E7 -8.07E7 -4.61 2.8534158E7 -7.82E7 -4.82 -6.6683 -0.9998 1260 SPBio_000287 N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O10 compound treatment 9.5795705E7 -1.43E7 -0.81 9.5519427E7 -1.12E7 -0.69 -1.064 -0.9966 1282 SPBio_000288 NS(=O)(=O)c1cc2c(N=CNS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O11 compound treatment 4.3350037E7 -6.67E7 -3.81 4.1552895E7 -6.52E7 -4.02 -5.5358 -0.9997 1352 SPBio_000289 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O12 compound treatment 1.02715724E8 -7330000.0 -0.42 1.04631494E8 -2080000.0 -0.13 -0.3872 -0.8832 1020 SPBio_000290 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O13 compound treatment 8.9387404E7 -2.07E7 -1.18 9.1440696E7 -1.53E7 -0.94 -1.5008 -0.9937 720 SPBio_000291 Fc1c[nH]c(=O)[nH]c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O14 compound treatment 9.73631E7 -1.27E7 -0.73 9.4450237E7 -1.23E7 -0.76 -1.0473 -0.9998 2069230 SPBio_000292 CN(C)CC[C@H](c1ccc(Cl)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O15 compound treatment 9.5908746E7 -1.41E7 -0.81 9.2634865E7 -1.41E7 -0.87 -1.1852 -0.9994 1154 SPBio_000293 O=C1CC2OCC=C3CN4CC[C@]56C4C[C@@H]3[C@@H]2C6N1c7ccccc75 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O16 compound treatment 9.8884107E7 -1.12E7 -0.64 9.5524957E7 -1.12E7 -0.69 -0.939 -0.9992 877 SPBio_000294 CC(C)(Oc1ccc(Cl)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O17 compound treatment 1.06805169E8 -3250000.0 -0.19 1.04368502E8 -2350000.0 -0.14 -0.2334 -0.9924 3177389 SPBio_000295 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O18 compound treatment 1.0006282E8 -9990000.0 -0.57 8.6807243E7 -1.99E7 -1.23 -1.2713 -0.9394 907 SPBio_000296 OC(=O)c1cc(O)c2cccc(O)c2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O19 compound treatment 3.106734E7 -7.9E7 -4.51 2.977219E7 -7.69E7 -4.74 -6.5456 -0.9997 1288 SPBio_000297 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O)[C@H](C)O2)N(C)C)c3c(O)c4C(=O)c5c(O)cccc5C(=O)c4cc3[C@H]1C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O20 compound treatment 3.2180772E7 -7.79E7 -4.45 3.0358828E7 -7.64E7 -4.71 -6.4751 -0.9996 1006 SPBio_000298 Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O21 compound treatment 1.09350155E8 -700000.0 -0.04 1.05989512E8 -725000.0 -0.04 -0.0599 -0.9985 3174227 SPBio_000299 CC[C@@H]1[C@@H](O)N2[C@H]3C[C@@]45C(O)C3[C@@H]1CC2[C@@H]5N(C)c6ccccc64 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O22 compound treatment 1.04513776E8 -5540000.0 -0.32 1.00458036E8 -6260000.0 -0.39 -0.4965 -0.9952 3077148 SPBio_000300 CCCCC(=O)Oc1ccccc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O23 mock treatment 1.07217956E8 -2830000.0 -0.16 1.00258998E8 -6460000.0 -0.4 -0.3959 -0.9214 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 O24 mock treatment 1.18654782E8 8600000.0 0.49 1.13731993E8 7020000.0 0.43 0.6536 0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P01 mock treatment 1.13844144E8 3790000.0 0.22 1.13515345E8 6800000.0 0.42 0.4497 0.9529 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P02 mock treatment 1.12297062E8 2250000.0 0.13 1.05514142E8 -1200000.0 -0.07 0.0385 0.2595 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P03 compound treatment 9.9873756E7 -1.02E7 -0.58 8.7405228E7 -1.93E7 -1.19 -1.2529 -0.9458 2060147 SPBio_000301 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P04 compound treatment 1.06424431E8 -3630000.0 -0.21 1.00217057E8 -6500000.0 -0.4 -0.4298 -0.953 2060138 SPBio_000302 C[C@]1([C@H]2[C@H](C(=O)O)[C@]3(CC(=C)[C@@]4(O)C3)[C@@H](CC4)[C@]52OC1=O)[C@@H](O)C=C5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P05 compound treatment 9.7811159E7 -1.22E7 -0.7 9.1354486E7 -1.54E7 -0.95 -1.1641 -0.9889 2060038 SPBio_000303 COC(=O)C[C@H]1C(C)(C)C(=O)C=C[C@]1(C)C2CC[C@@]3(C)[C@@H](OC(=O)C=C3C2=C)c4ccoc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P06 compound treatment 4.880215E7 -6.12E7 -3.5 5.3216035E7 -5.35E7 -3.3 -4.8071 -0.9996 1098 SPBio_000304 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P07 compound treatment 1.04398393E8 -5650000.0 -0.32 1.07620504E8 906000.0 0.06 -0.1889 -0.5764 2060055 SPBio_000305 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P08 compound treatment 9.3375637E7 -1.67E7 -0.95 9.9105243E7 -7610000.0 -0.47 -1.0055 -0.9467 2060140 SPBio_000306 COc1cc2occc2c3oc(=O)ccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P09 compound treatment 8.5841273E7 -2.42E7 -1.38 8.7385695E7 -1.93E7 -1.19 -1.8209 -0.9972 1609 SPBio_000307 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P10 compound treatment 2.9426491E7 -8.06E7 -4.61 2.8501133E7 -7.82E7 -4.82 -6.6674 -0.9997 2060142 SPBio_000308 CC(=O)OC1C/C(=C/CC/C(=C/CC[C@](C)(O)C2CC1C(=C)C(=O)O2)/C)/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P11 compound treatment 9.1736129E7 -1.83E7 -1.05 9.0763E7 -1.6E7 -0.98 -1.4354 -0.9995 2060059 SPBio_000309 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](C[C@H]5O[C@]543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P12 compound treatment 9.9687501E7 -1.04E7 -0.59 1.02182721E8 -4530000.0 -0.28 -0.6163 -0.9412 3059434 SPBio_000310 C[C@]12CC[C@@H]3[C@H](CC3(C)C)C(=O)CC[C@H]2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P13 compound treatment 8.7481772E7 -2.26E7 -1.29 7.8427471E7 -2.83E7 -1.74 -2.145 -0.989 2060060 SPBio_000311 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)[C@@]2(C)C=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P14 compound treatment 8.612845E7 -2.39E7 -1.37 8.5560239E7 -2.12E7 -1.3 -1.8888 -0.9997 2060170 SPBio_000312 CC(=O)OC1CCC2(O)CC1(C)CCC3C2CC3(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P15 compound treatment 9.0865836E7 -1.92E7 -1.1 8.7662953E7 -1.91E7 -1.17 -1.6057 -0.9994 2060062 SPBio_000313 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P16 compound treatment 9.9551458E7 -1.05E7 -0.6 8.8647647E7 -1.81E7 -1.11 -1.2118 -0.9579 2060421 SPBio_000314 C[C@](O)(CCC1C(=C)C[C@H](O)C2C(C)(C)CCCC12C)C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P17 compound treatment 9.2624672E7 -1.74E7 -1.0 8.5949635E7 -2.08E7 -1.28 -1.6093 -0.9923 2060063 SPBio_000315 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](C(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P18 compound treatment 9.1413867E7 -1.86E7 -1.07 9.3003358E7 -1.37E7 -0.85 -1.3508 -0.9934 3177379 SPBio_000316 CC(=O)O[C@H]1CC(=C)C(CC[C@](C)(O)C=C)C2(C)CCCC(C)(C)C12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P19 compound treatment 9.0877478E7 -1.92E7 -1.1 9.2380243E7 -1.43E7 -0.88 -1.3996 -0.9943 2060066 SPBio_000317 COC(=O)CC1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P20 compound treatment 9.6974716E7 -1.31E7 -0.75 9.521558E7 -1.15E7 -0.71 -1.0296 -0.9997 2060175 SPBio_000318 C[C@](O)(CCC1C(=C)CCC2[C@@](C)(CO)CCC[C@]12C)C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P21 compound treatment 1.00903322E8 -9150000.0 -0.52 9.6222455E7 -1.05E7 -0.65 -0.827 -0.9944 3173867 SPBio_000319 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P22 compound treatment 1.09551758E8 -498000.0 -0.03 1.00969707E8 -5750000.0 -0.35 -0.2706 -0.7615 2060166 SPBio_000320 CC1(C)CC2C1CCC(=C)/C(=N\O)/CCC2=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P23 mock treatment 1.19184177E8 9130000.0 0.52 1.10195116E8 3480000.0 0.21 0.5208 0.9228 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2158 P24 mock treatment 1.24479618E8 1.44E7 0.82 1.19467648E8 1.28E7 0.79 1.139 0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A01 mock treatment 1.19143408E8 8980000.0 0.51 1.19591505E8 1.29E7 0.8 0.9273 0.9772 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A02 mock treatment 1.13236282E8 3080000.0 0.18 1.14766262E8 8120000.0 0.5 0.4783 0.9014 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A03 compound treatment 5.1513714E7 -5.86E7 -3.35 5.6728355E7 -4.99E7 -3.08 -4.5458 -0.9991 1030891 SPBio_000321 Cc1cc(=O)oc2c(O)c(O)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A04 compound treatment 1.1409728E8 3940000.0 0.23 1.1510989E8 8460000.0 0.52 0.5281 0.9293 1109169 SPBio_000322 COc1ccc2c(=O)c(coc2c1)c3cc4OCOc4cc3OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A05 compound treatment 9.2884864E7 -1.73E7 -0.99 1.04025578E8 -2620000.0 -0.16 -0.8123 -0.812 1552436 SPBio_000323 COc1ccc(cc1)c2cc(=O)c3cc(OC)ccc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A06 compound treatment 9.3845518E7 -1.63E7 -0.93 1.09089507E8 2440000.0 0.15 -0.5528 -0.5852 2060405 SPBio_000324 CC1(C)[C@H](CC(=O)O)[C@@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]3(O)C[C@@H](C1=O)C2=O)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A07 compound treatment 9.035994E7 -1.98E7 -1.13 1.03692854E8 -2950000.0 -0.18 -0.9289 -0.8104 2060323 SPBio_000325 COc1ccccc1c2cc(=O)c3c(OC)cccc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A08 compound treatment 9.1575982E7 -1.86E7 -1.06 1.00494094E8 -6150000.0 -0.38 -1.0191 -0.9037 2060179 SPBio_000326 COc1cccc2c1CCC3CC(=O)CC[C@@]32C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A09 compound treatment 9.0392966E7 -1.98E7 -1.13 1.09004256E8 2360000.0 0.15 -0.696 -0.611 1499608 SPBio_000327 COc1ccc2c(=O)cc(oc2c1)c3ccccc3OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A10 compound treatment 8.9090948E7 -2.11E7 -1.2 1.03164079E8 -3480000.0 -0.21 -1.0032 -0.8202 3077346 SPBio_000328 COC(=O)c1c(C)cc(OC)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A11 compound treatment 8.8574979E7 -2.16E7 -1.23 1.03546976E8 -3100000.0 -0.19 -1.0074 -0.807 777 SPBio_000329 Oc1ccc(cc1)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A12 compound treatment 8.6295857E7 -2.39E7 -1.36 9.8475707E7 -8170000.0 -0.5 -1.3205 -0.9083 1009851 SPBio_000330 O=C1c2ccccc2C(=O)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A13 compound treatment 8.0547323E7 -2.96E7 -1.69 9.5184757E7 -1.15E7 -0.71 -1.6963 -0.9249 2060418 SPBio_000331 COc1ccccc1c2cc(=O)c3cccc(OC)c3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A14 compound treatment 3.4365233E7 -7.58E7 -4.33 3.7023289E7 -6.96E7 -4.29 -6.0977 -1.0 2060380 SPBio_000332 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)C3(F)[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A15 compound treatment 8.5515441E7 -2.46E7 -1.41 9.6111729E7 -1.05E7 -0.65 -1.4551 -0.9382 2060322 SPBio_000333 COc1ccc2c(=O)c(OC)c(oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A16 compound treatment 8.8735496E7 -2.14E7 -1.22 1.00287412E8 -6360000.0 -0.39 -1.1429 -0.889 2579 SPBio_000334 OCCSCCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A17 compound treatment 9.1571684E7 -1.86E7 -1.06 9.9322714E7 -7320000.0 -0.45 -1.0704 -0.9273 3173852 SPBio_000335 COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)C(O)[C@H](O)C3O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)cc2O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A18 compound treatment 1.17931802E8 7770000.0 0.44 1.1647714E8 9830000.0 0.61 0.7426 0.9883 3173468 SPBio_000336 COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A19 compound treatment 9.3620918E7 -1.65E7 -0.95 1.01579995E8 -5070000.0 -0.31 -0.8892 -0.8932 3177315 SPBio_000337 CC1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)c4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A20 compound treatment 1.00016266E8 -1.01E7 -0.58 1.11007751E8 4360000.0 0.27 -0.2198 -0.3439 1445 SPBio_000338 C/C=C(/C)\C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@@H]4[C@@]2(C[C@@]5(O)[C@@H]6CN7C[C@@H](C)CC[C@H]7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]45O)O[C@@]31O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A21 compound treatment 9.7867842E7 -1.23E7 -0.7 1.05456154E8 -1190000.0 -0.07 -0.5486 -0.7767 976 SPBio_000339 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A22 compound treatment 1.08961176E8 -1200000.0 -0.07 1.12872687E8 6230000.0 0.38 0.223 0.5718 1112405 SPBio_000340 COc1cc2OCOc2cc1c3cc4cc5ccoc5cc4oc3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A23 mock treatment 1.14507467E8 4350000.0 0.25 1.18607452E8 1.2E7 0.74 0.6971 0.8959 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 A24 mock treatment 1.26393913E8 1.62E7 0.93 1.27163833E8 2.05E7 1.26 1.5504 0.9884 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B01 mock treatment 1.21996082E8 1.18E7 0.68 1.20014727E8 1.34E7 0.82 1.0611 0.9952 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B02 mock treatment 1.0119285E8 -8970000.0 -0.51 1.00494089E8 -6150000.0 -0.38 -0.6305 -0.989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B03 compound treatment 2.8664369E7 -8.15E7 -4.66 2.8201382E7 -7.84E7 -4.84 -6.7126 -0.9998 1011006 SPBio_000341 O=C1C=CC(=O)c2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B04 compound treatment 8.7513172E7 -2.26E7 -1.29 9.5542435E7 -1.11E7 -0.68 -1.3992 -0.9556 3172845 SPBio_000342 CCC(C)C(=O)O[C@H]1[C@H](O)C2C(CN3CC(C)CCC3[C@@]2(C)O)C4C[C@]5(O[C@@]6(O)C7C(OC(=O)C)[C@@H](OC(=O)C)C5[C@@]41O)[C@@]7(C)CCC6OC(=O)C(C)(O)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B05 compound treatment 1.01513202E8 -8650000.0 -0.49 9.6139019E7 -1.05E7 -0.65 -0.8074 -0.9911 1000322 SPBio_000343 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(=O)O)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B06 compound treatment 9.571861E7 -1.44E7 -0.83 9.681146E7 -9830000.0 -0.61 -1.0122 -0.9885 2060143 SPBio_000344 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B07 compound treatment 8.8463035E7 -2.17E7 -1.24 9.5074799E7 -1.16E7 -0.71 -1.3812 -0.9655 1001496 SPBio_000345 NC(=O)N1c2ccccc2CC(=O)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B08 compound treatment 9.0862082E7 -1.93E7 -1.1 9.7553901E7 -9090000.0 -0.56 -1.1762 -0.9507 1046 SPBio_000346 CC1C2C(CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC(=O)[C@]23C)OC61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B09 compound treatment 7.054999E7 -3.96E7 -2.26 7.9541621E7 -2.71E7 -1.67 -2.7821 -0.9888 3198312 SPBio_000347 C[C@@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C2CC[C@]51CCC(=O)O5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B10 compound treatment 9.0013837E7 -2.01E7 -1.15 9.3291031E7 -1.34E7 -0.82 -1.3962 -0.9865 2060339 SPBio_000348 COc1cc2N3C4[C@H]5[C@H]6C[C@@H]7N(CC[C@@]74c2cc1OC)CC6=CCOC5CC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B11 compound treatment 6.5885204E7 -4.43E7 -2.53 8.6587889E7 -2.01E7 -1.24 -2.6635 -0.9457 2069295 SPBio_000349 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)c5ccccc5c6nnn[nH]6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B12 compound treatment 1.0244256E8 -7720000.0 -0.44 1.01582714E8 -5060000.0 -0.31 -0.5325 -0.9856 3059432 SPBio_000350 CC(C)CCCC(C)[C@H]1CCC2C3C(CC[C@]12C)[C@@]4(C)CC[C@H](O)CC4=CC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B13 compound treatment 6.1076771E7 -4.91E7 -2.81 8.3799933E7 -2.28E7 -1.41 -2.9793 -0.9492 3480246 SPBio_000351 CCOC(=O)C1=C(COCCN)NC(=C(C1c2ccccc2Cl)C(=O)OC)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B14 compound treatment 7.6699662E7 -3.35E7 -1.91 8.8513668E7 -1.81E7 -1.12 -2.1425 -0.9673 2060325 SPBio_000352 COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(c34)-c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B15 compound treatment 9.5253966E7 -1.49E7 -0.85 9.09862E7 -1.57E7 -0.97 -1.2849 -0.9981 1001366 SPBio_000353 COc1c(N2CCNC(C)C2)c(F)cc3c(=O)c(cn(C4CC4)c13)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B16 compound treatment 8.4414686E7 -2.57E7 -1.47 8.9808323E7 -1.68E7 -1.04 -1.7743 -0.9854 2060251 SPBio_000354 NCC(N)C(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B17 compound treatment 8.7339459E7 -2.28E7 -1.3 9.3316434E7 -1.33E7 -0.82 -1.5032 -0.9752 3198313 SPBio_000355 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)C5[C@H](O)C[C@]43C)[C@@H]2[C@H]1C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B18 compound treatment 6.3672597E7 -4.65E7 -2.66 6.8204552E7 -3.84E7 -2.37 -3.5542 -0.9984 297849 SPBio_000356 COc1ccc2c(c1)[nH]c3c(C)nccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B19 compound treatment 8.4609985E7 -2.56E7 -1.46 9.1285358E7 -1.54E7 -0.95 -1.702 -0.978 1001346 SPBio_000357 OC(CC[C@@H]1[C@H](N(C1=O)c2ccc(F)cc2)c3ccc(O)cc3)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B20 compound treatment 1.06734478E8 -3430000.0 -0.2 1.03844149E8 -2800000.0 -0.17 -0.2605 -0.998 2060051 SPBio_000358 Cc1cc(=O)c2c(O)cc(O)c(C)c2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B21 compound treatment 9.6563637E7 -1.36E7 -0.78 1.02046613E8 -4600000.0 -0.28 -0.7499 -0.9066 1333 SPBio_000359 CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B22 compound treatment 9.6717829E7 -1.34E7 -0.77 1.01667933E8 -4980000.0 -0.31 -0.7602 -0.9189 956 SPBio_000360 CCn1nc(C(=O)O)c(=O)c2cc3OCOc3cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B23 mock treatment 9.853193E7 -1.16E7 -0.66 9.7149438E7 -9500000.0 -0.59 -0.8838 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 B24 mock treatment 1.14271243E8 4110000.0 0.23 1.22757971E8 1.61E7 0.99 0.8685 0.8509 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C01 mock treatment 1.08479017E8 -1680000.0 -0.1 1.05699646E8 -945000.0 -0.06 -0.1092 -0.9713 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C02 mock treatment 9.9037088E7 -1.11E7 -0.64 9.5225924E7 -1.14E7 -0.7 -0.9473 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C03 compound treatment 8.9955105E7 -2.02E7 -1.15 8.8677318E7 -1.8E7 -1.11 -1.5997 -0.9998 2060213 SPBio_000361 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)[C@H]6O[C@H]6C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C04 compound treatment 9.5372086E7 -1.48E7 -0.85 9.7517294E7 -9130000.0 -0.56 -0.9955 -0.9805 1530 SPBio_000362 COc1ccc2c3CCN=C(C)c3[nH]c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C05 compound treatment 9.8510324E7 -1.17E7 -0.67 9.7134384E7 -9510000.0 -0.59 -0.8854 -0.998 3173352 SPBio_000363 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C06 compound treatment 9.7214406E7 -1.29E7 -0.74 9.4928064E7 -1.17E7 -0.72 -1.0339 -0.9999 2060407 SPBio_000364 COc1ccc(/C=C/C(=O)O)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C07 compound treatment 9.3265684E7 -1.69E7 -0.97 9.2774424E7 -1.39E7 -0.86 -1.2873 -0.9982 2060232 SPBio_000365 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C08 compound treatment 9.1954249E7 -1.82E7 -1.04 9.0352387E7 -1.63E7 -1.0 -1.4459 -0.9998 2060504 SPBio_000366 Cc1cc(O)c(C)c(O)c1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C09 compound treatment 8.5012833E7 -2.51E7 -1.44 8.3898576E7 -2.27E7 -1.4 -2.0077 -0.9999 2060233 SPBio_000367 COC(=O)C[C@H]1C(C)(C)[C@H](O)[C@@H]2CC3=C4CC(O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C10 compound treatment 8.4463423E7 -2.57E7 -1.47 7.83272E7 -2.83E7 -1.75 -2.2728 -0.9963 2060400 SPBio_000368 CC(C)c1ccc2c(CCC3[C@](C)(CN)CCC[C@@]32C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C11 compound treatment 8.9357064E7 -2.08E7 -1.19 8.621649E7 -2.04E7 -1.26 -1.7311 -0.9996 2060235 SPBio_000369 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)[C@@H]3O[C@@H]3[C@]2(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C5[C@]14C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C12 compound treatment 8.9352081E7 -2.08E7 -1.19 8.8457534E7 -1.82E7 -1.12 -1.6337 -0.9996 2060317 SPBio_000370 COc1cc(OC)c2c(OC)c(c3ccc4OCOc4c3)c(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C13 compound treatment 9.3273566E7 -1.69E7 -0.97 9.0293329E7 -1.64E7 -1.01 -1.3952 -0.9998 2060237 SPBio_000371 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)C(=O)O)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C14 compound treatment 8.0482175E7 -2.97E7 -1.7 8.3070107E7 -2.36E7 -1.45 -2.2269 -0.997 891 SPBio_000372 CC(=O)OCC(=O)[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C15 compound treatment 8.278669E7 -2.74E7 -1.56 8.5619557E7 -2.1E7 -1.3 -2.0227 -0.9956 2060240 SPBio_000373 CC1=C2C(O)C(=O)OC3CC4C(C)(C)C(=O)C=C[C@]4(C)C(CC1)[C@@]32C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C16 compound treatment 8.4202401E7 -2.6E7 -1.48 8.8706094E7 -1.79E7 -1.11 -1.8309 -0.9895 2060458 SPBio_000374 CC(=O)Oc1cccc(C(=O)O)c1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C17 compound treatment 8.9033014E7 -2.11E7 -1.21 9.0403445E7 -1.62E7 -1.0 -1.5617 -0.9957 2060241 SPBio_000375 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C18 compound treatment 3.4130487E7 -7.6E7 -4.35 3.6011663E7 -7.06E7 -4.35 -6.1513 -1.0 3172856 SPBio_000376 O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4C(C32)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C19 compound treatment 8.8816577E7 -2.13E7 -1.22 8.8543355E7 -1.81E7 -1.12 -1.6516 -0.999 2060026 SPBio_000377 COC(=O)C[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C20 compound treatment 9.5469783E7 -1.47E7 -0.84 9.4965223E7 -1.17E7 -0.72 -1.1028 -0.9971 1010689 SPBio_000378 COc1cc(CC=C)c(OC)c2OCOc21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C21 compound treatment 9.4042252E7 -1.61E7 -0.92 9.2269416E7 -1.44E7 -0.89 -1.278 -0.9998 2060086 SPBio_000379 CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@@H](OC(=O)CC32OC4(C)OC53[C@H](OC(=O)C(C)C)[C@@]6(O)[C@@H](OC(=O)C7(C)OC7C)[C@@]8(C)C[C@]6(O)[C@@](C)([C@H]8CC(=O)OC)C15O4)c9ccoc9 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C22 compound treatment 1.01614162E8 -8550000.0 -0.49 9.7935825E7 -8710000.0 -0.54 -0.725 -0.9989 1000142 SPBio_000380 CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C23 mock treatment 9.9786517E7 -1.04E7 -0.59 1.05645027E8 -1000000.0 -0.06 -0.4628 -0.7764 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 C24 mock treatment 1.21892874E8 1.17E7 0.67 1.13879973E8 7230000.0 0.45 0.7895 0.9804 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D01 mock treatment 1.04660226E8 -5500000.0 -0.31 1.05396279E8 -1250000.0 -0.08 -0.2767 -0.855 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D02 mock treatment 9.5624894E7 -1.45E7 -0.83 9.2920553E7 -1.37E7 -0.85 -1.1856 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D03 compound treatment 1.05667594E8 -4490000.0 -0.26 1.03551747E8 -3090000.0 -0.19 -0.3164 -0.9893 3078456 SPBio_000381 CC(=CCC[C@](C)(O)C1CCC(=CC1)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D04 compound treatment 9.4031134E7 -1.61E7 -0.92 8.9041605E7 -1.76E7 -1.09 -1.4191 -0.9967 2060067 SPBio_000382 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D05 compound treatment 1.00015244E8 -1.01E7 -0.58 9.3872257E7 -1.28E7 -0.79 -0.9667 -0.9887 1002856 SPBio_000383 CCC(C(=O)N)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D06 compound treatment 1.00782077E8 -9380000.0 -0.54 9.8156154E7 -8490000.0 -0.52 -0.749 -0.9999 3174120 SPBio_000384 CCCCCCCCCCCC[C@@H]([C@@H](C)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D07 compound treatment 6.5493618E7 -4.47E7 -2.55 6.1108207E7 -4.55E7 -2.81 -3.7899 -0.9989 3078457 SPBio_000385 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D08 compound treatment 9.9595156E7 -1.06E7 -0.6 9.8493556E7 -8150000.0 -0.5 -0.7823 -0.9958 1000219 SPBio_000386 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D09 compound treatment 9.6777223E7 -1.34E7 -0.76 9.4414343E7 -1.22E7 -0.75 -1.074 -1.0 2069284 SPBio_000387 COc1ccc2cc(ccc2c1)[C@H](C)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D10 compound treatment 9.7308466E7 -1.29E7 -0.73 9.2943312E7 -1.37E7 -0.84 -1.1166 -0.9976 3177312 SPBio_000388 CC(C)CCCC(C)C1CCC2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D11 compound treatment 9.1979631E7 -1.82E7 -1.04 9.0656024E7 -1.6E7 -0.99 -1.4317 -0.9997 1377 SPBio_000389 CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D12 compound treatment 8.8816055E7 -2.13E7 -1.22 8.3440853E7 -2.32E7 -1.43 -1.874 -0.9969 1064620 SPBio_000390 COC1=CC23CCCN3CCc4cc5OCOc5cc4C2C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D13 compound treatment 8.795773E7 -2.22E7 -1.27 8.8509606E7 -1.81E7 -1.12 -1.6877 -0.998 1079 SPBio_000391 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D14 compound treatment 8.8091502E7 -2.21E7 -1.26 8.7663905E7 -1.9E7 -1.17 -1.7192 -0.9993 1000141 SPBio_000392 OC[C@H]1O[C@@H](Oc2cc3ccc(=O)oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D15 compound treatment 8.9008326E7 -2.12E7 -1.21 8.7679562E7 -1.9E7 -1.17 -1.6815 -0.9999 2060414 SPBio_000393 OC(=O)c1nc2cc(Cl)c(Cl)cc2nc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D16 compound treatment 8.7807395E7 -2.24E7 -1.28 8.4663783E7 -2.2E7 -1.35 -1.8615 -0.9996 2060229 SPBio_000394 Oc1cc(OC(=O)c2cc(O)c(O)c(O)c2)c3C[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)[C@H](Oc3c1)c5cc(O)c(O)c(O)c5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D17 compound treatment 9.2236786E7 -1.79E7 -1.02 8.8768831E7 -1.79E7 -1.1 -1.5035 -0.9993 1000393 SPBio_000395 CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D18 compound treatment 9.6472049E7 -1.37E7 -0.78 9.536361E7 -1.13E7 -0.7 -1.0449 -0.9983 2060137 SPBio_000396 COc1ccc(cc1)c2coc3c(OC)c(OC)cc(OC)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D19 compound treatment 9.4661815E7 -1.55E7 -0.89 8.9903202E7 -1.67E7 -1.03 -1.3561 -0.9971 3055414 SPBio_000397 OC[C@@H]1CCCN2CCCC[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D20 compound treatment 9.8155127E7 -1.2E7 -0.69 9.4791112E7 -1.19E7 -0.73 -1.0018 -0.9995 2060196 SPBio_000398 COc1cc2OCC3Oc4cc5OC(C)(C)C=Cc5c(O)c4C(=O)C3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D21 compound treatment 9.9452942E7 -1.07E7 -0.61 9.6564469E7 -1.01E7 -0.62 -0.8721 -1.0 2060489 SPBio_000399 C/C=C(/C)\C(=O)O[C@@H]1Cc2c(OC1(C)C)ccc3ccc(=O)oc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D22 compound treatment 9.6624334E7 -1.35E7 -0.77 9.2935823E7 -1.37E7 -0.85 -1.1446 -0.999 3078459 SPBio_000400 CCN(CCCc1ccccc1)CCCc2ccccc2.CC(CC(=O)O)(CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D23 mock treatment 1.05513781E8 -4650000.0 -0.27 1.03080325E8 -3560000.0 -0.22 -0.3432 -0.9956 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 D24 mock treatment 1.10120345E8 -40000.0 0.0 1.12557971E8 5910000.0 0.36 0.2561 0.7027 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E01 mock treatment 1.06603367E8 -3560000.0 -0.2 1.05556765E8 -1090000.0 -0.07 -0.1912 -0.8931 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E02 mock treatment 1.0712727E8 -3030000.0 -0.17 1.01737853E8 -4910000.0 -0.3 -0.3365 -0.9651 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E03 compound treatment 1.04535925E8 -5620000.0 -0.32 1.05193102E8 -1450000.0 -0.09 -0.2906 -0.8709 2060027 SPBio_000401 CC(=O)O[C@@H]1CC2C(C)(C)[C@@H](O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E04 compound treatment 1.04503793E8 -5660000.0 -0.32 1.02558198E8 -4090000.0 -0.25 -0.4067 -0.9924 2060441 SPBio_000402 OC(=O)c1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E05 compound treatment 9.4331978E7 -1.58E7 -0.9 9.3585039E7 -1.31E7 -0.81 -1.2089 -0.9983 2060029 SPBio_000403 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E06 compound treatment 9.9199887E7 -1.1E7 -0.63 9.7645471E7 -9000000.0 -0.55 -0.8352 -0.9982 2060452 SPBio_000404 CC1(C)O[C@@H]2C[C@](O)(C[C@@H](O)[C@@H]2O1)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E07 compound treatment 9.885018E7 -1.13E7 -0.65 9.7094937E7 -9550000.0 -0.59 -0.8733 -0.9989 3173368 SPBio_000405 O=C1CC[C@]2(/C=C/C(=O)NCCCCNCCCNC(=O)\C=C\c3ccc4O[C@@H]2C1)c4c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E08 compound treatment 9.5072068E7 -1.51E7 -0.86 9.1165111E7 -1.55E7 -0.95 -1.2845 -0.9987 2060411 SPBio_000406 O[C@H]1Cc2ccc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E09 compound treatment 9.6007313E7 -1.42E7 -0.81 9.4783567E7 -1.19E7 -0.73 -1.089 -0.9987 2060039 SPBio_000407 CC(=CCc1c(O)cc2oc(C)cc(=O)c2c1O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E10 compound treatment 6.3956887E7 -4.62E7 -2.64 6.43651E7 -4.23E7 -2.61 -3.7101 -1.0 2060392 SPBio_000408 CCOc1ccc(cc1)C(=O)c2ccc(O)c(O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E11 compound treatment 9.1255041E7 -1.89E7 -1.08 9.0545328E7 -1.61E7 -0.99 -1.4658 -0.9991 2060056 SPBio_000409 COc1cc(O)c2c(=O)cc(C)oc2c1CC=C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E12 compound treatment 9.7402532E7 -1.28E7 -0.73 9.7205776E7 -9440000.0 -0.58 -0.927 -0.9937 2069228 SPBio_000410 COc1ccc2oc3ccccc3c(=O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E13 compound treatment 8.9800202E7 -2.04E7 -1.16 9.2174658E7 -1.45E7 -0.89 -1.4535 -0.9914 2060061 SPBio_000411 Cc1cc(=O)c2c(O)c3CCC(C)(C)Oc3cc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E14 compound treatment 9.4993976E7 -1.52E7 -0.87 9.0945716E7 -1.57E7 -0.97 -1.2972 -0.9985 1050711 SPBio_000412 COc1cc(OC)cc(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E15 compound treatment 8.8595845E7 -2.16E7 -1.23 8.4493152E7 -2.22E7 -1.37 -1.837 -0.9987 3058621 SPBio_000413 C[C@H]1C2[C@H](C[C@H]3C4CC=C5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CN6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E16 compound treatment 9.8086873E7 -1.21E7 -0.69 9.5902117E7 -1.07E7 -0.66 -0.9562 -0.9998 973 SPBio_000414 COc1ccc(cc1)C2C(=O)c3ccccc3C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E17 compound treatment 9.8001925E7 -1.22E7 -0.69 1.00182407E8 -6460000.0 -0.4 -0.773 -0.9651 2060161 SPBio_000415 CC(=C)[C@H]1COc2cc3oc(=O)ccc3cc2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E18 compound treatment 6.5770599E7 -4.44E7 -2.54 5.9672347E7 -4.7E7 -2.9 -3.8413 -0.9978 360 SPBio_000416 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E19 compound treatment 9.6555132E7 -1.36E7 -0.78 9.2636851E7 -1.4E7 -0.86 -1.1604 -0.9986 1352641 SPBio_000417 COc1c2ccoc2nc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E20 compound treatment 9.891803E7 -1.12E7 -0.64 9.3784115E7 -1.29E7 -0.79 -1.0149 -0.9946 2060502 SPBio_000418 COc1cc(cc(OC)c1O)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E21 compound treatment 1.03006172E8 -7150000.0 -0.41 9.6149264E7 -1.05E7 -0.65 -0.7466 -0.9755 2060295 SPBio_000419 CC(C)C1COc2cc3oc(=O)ccc3cc2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E22 compound treatment 2.8564387E7 -8.16E7 -4.66 2.7854917E7 -7.88E7 -4.86 -6.7318 -0.9998 862 SPBio_000420 CCCCCCCCCCCCCCCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E23 mock treatment 1.04036371E8 -6120000.0 -0.35 1.01447119E8 -5200000.0 -0.32 -0.4741 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 E24 mock treatment 1.19719525E8 9560000.0 0.55 1.08749217E8 2100000.0 0.13 0.478 0.8513 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F01 mock treatment 1.12087827E8 1930000.0 0.11 1.08046277E8 1400000.0 0.09 0.139 0.9928 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F02 mock treatment 1.11120922E8 961000.0 0.05 1.04579125E8 -2070000.0 -0.13 -0.0512 -0.3694 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F03 compound treatment 1.0567514E8 -4490000.0 -0.26 9.9953927E7 -6690000.0 -0.41 -0.4729 -0.9738 1140 SPBio_000421 CC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F04 compound treatment 1.03764903E8 -6400000.0 -0.37 9.8581467E7 -8060000.0 -0.5 -0.6099 -0.9886 3198317 SPBio_000422 CCOC(=O)[C@H](CCc1ccccc1)N[C@H](C)C(=O)N2[C@@H](C[C@@H]3CCCC[C@@H]32)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F05 compound treatment 9.9646113E7 -1.05E7 -0.6 9.642716E7 -1.02E7 -0.63 -0.8703 -0.9997 3173234 SPBio_000423 Cn1c(=O)[nH]c(=O)c2nc[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F06 compound treatment 7.280152E7 -3.74E7 -2.14 7.2023125E7 -3.46E7 -2.13 -3.0189 -1.0 653 SPBio_000424 Oc1cc2cccc(O)c(=O)c2c(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F07 compound treatment 1.00725921E8 -9430000.0 -0.54 9.5582825E7 -1.11E7 -0.68 -0.8634 -0.9932 1090658 SPBio_000425 COc1cc(O)c2C(=O)c3c(O)cc(C)cc3C(=O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F08 compound treatment 9.8494333E7 -1.17E7 -0.67 9.2454244E7 -1.42E7 -0.87 -1.09 -0.991 1013195 SPBio_000426 Nc1ncnc2[nH]cnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F09 compound treatment 7.306532E7 -3.71E7 -2.12 6.9088461E7 -3.76E7 -2.32 -3.1361 -0.999 1043296 SPBio_000427 Cc1nccc2c3ccc(O)cc3[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F10 compound treatment 9.6996362E7 -1.32E7 -0.75 9.6097254E7 -1.05E7 -0.65 -0.9917 -0.9974 3177456 SPBio_000428 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F11 compound treatment 9.5423808E7 -1.47E7 -0.84 9.2720049E7 -1.39E7 -0.86 -1.2025 -1.0 3480229 SPBio_000429 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F12 compound treatment 5.07137E7 -5.94E7 -3.4 5.07389E7 -5.59E7 -3.45 -4.8392 -1.0 1113269 SPBio_000430 CN1Cc2c3OCOc3ccc2C4C(O)Cc5cc6OCOc6cc5C41 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F13 compound treatment 9.2910225E7 -1.73E7 -0.99 8.8719194E7 -1.79E7 -1.1 -1.4785 -0.9984 1001491 SPBio_000431 CCCc1nc(c(C(=O)OCc2oc(=O)oc2C)n1Cc3ccc(cc3)c4ccccc4c5nn[nH]n5)C(C)(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F14 compound treatment 5.0949031E7 -5.92E7 -3.38 5.1827116E7 -5.48E7 -3.38 -4.7823 -1.0 1020463 SPBio_000432 Oc1cc2ccc(=O)oc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F15 compound treatment 9.2417965E7 -1.77E7 -1.01 9.2476798E7 -1.42E7 -0.87 -1.3346 -0.9972 1000878 SPBio_000433 OCCN1C[C@@H](O)[C@@H](O)C(O)C1CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F16 compound treatment 9.0555112E7 -1.96E7 -1.12 8.7429042E7 -1.92E7 -1.18 -1.6299 -0.9996 3174244 SPBio_000434 N=c1[nH]c(=O)c2[nH]c(=O)c(=O)[nH]c2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F17 compound treatment 9.5524294E7 -1.46E7 -0.84 9.3712491E7 -1.29E7 -0.8 -1.1552 -0.9997 1001030 SPBio_000435 Cc1onc(c1c2ccc(cc2)S(=O)(=O)N)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F18 compound treatment 9.8687345E7 -1.15E7 -0.66 9.8990932E7 -7650000.0 -0.47 -0.7973 -0.987 1048361 SPBio_000436 c1ccc2c(c1)[nH]c3cnccc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F19 compound treatment 9.9320843E7 -1.08E7 -0.62 9.6785487E7 -9860000.0 -0.61 -0.8678 -1.0 3198314 SPBio_000437 CCC1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(OC)C3(CCCn4cnc(c4)c5cccnc5)C[C@@H](C)C(=O)[C@H](C)[C@H]6N(C3)C(=O)O[C@@]61C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F20 compound treatment 9.7634725E7 -1.25E7 -0.72 9.8823772E7 -7820000.0 -0.48 -0.8471 -0.9815 2069231 SPBio_000438 CC(=CCc1cc(ccc1O)C(=O)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F21 compound treatment 1.01457792E8 -8700000.0 -0.5 9.3539841E7 -1.31E7 -0.81 -0.9229 -0.9729 1002855 SPBio_000439 CCC(C(=O)O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F22 compound treatment 1.00986969E8 -9170000.0 -0.52 9.5386807E7 -1.13E7 -0.69 -0.8614 -0.9904 819 SPBio_000440 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F23 mock treatment 1.01327467E8 -8830000.0 -0.5 9.5244456E7 -1.14E7 -0.7 -0.8539 -0.9868 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 F24 mock treatment 1.19281123E8 9120000.0 0.52 1.05321333E8 -1320000.0 -0.08 0.3109 0.5892 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G01 mock treatment 1.04106203E8 -6050000.0 -0.35 1.00754077E8 -5890000.0 -0.36 -0.5014 -0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G02 mock treatment 1.07361946E8 -2800000.0 -0.16 1.03412732E8 -3230000.0 -0.2 -0.254 -0.9941 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G03 compound treatment 1.06794297E8 -3370000.0 -0.19 1.02606602E8 -4040000.0 -0.25 -0.3121 -0.9919 2060058 SPBio_000441 CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@@H](O)C(C)(C)C5CC[C@]43C)C2C1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G04 compound treatment 3.6815017E7 -7.33E7 -4.19 3.701614E7 -6.96E7 -4.29 -5.999 -0.9999 1057125 SPBio_000442 CC(C)(C=C)c1c2OC(C)(C)C=Cc2c(O)c3c(=O)c4ccc(O)c(O)c4oc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G05 compound treatment 1.02760296E8 -7400000.0 -0.42 1.01104184E8 -5540000.0 -0.34 -0.5406 -0.9944 3173478 SPBio_000443 C[C@H]1C(=O)CCC2[C@]1(C)CCC3[C@@]2(C)CC[C@@]4(C)C5CC(C)(C)CC[C@]5(C)CC[C@]34C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G06 compound treatment 1.14511354E8 4350000.0 0.25 1.13478133E8 6830000.0 0.42 0.4737 0.9684 3173115 SPBio_000444 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@]61CCC(C)CN6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G07 compound treatment 9.9123608E7 -1.1E7 -0.63 9.6580498E7 -1.01E7 -0.62 -0.8847 -1.0 3054135 SPBio_000445 CC(=O)O[C@H]1CC[C@@]2(C)C(CC[C@]3(C)C2CC=C4C5CC(C)(C)CC[C@]5(C)CC[C@]43C)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G08 compound treatment 2.9025178E7 -8.11E7 -4.64 2.8604092E7 -7.8E7 -4.81 -6.6805 -0.9998 2060429 SPBio_000446 COC1CC(O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)C(CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)OC(C)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G09 compound treatment 9.4996183E7 -1.52E7 -0.87 9.7787862E7 -8860000.0 -0.55 -0.9989 -0.9752 2060065 SPBio_000447 COC[C@@]12CN(C=O)C3[C@@H]4[C@H](OC)C2[C@]3(C5CC6(O)C(OC(=O)c7ccccc7)C5C4(OC(=O)C)C(O)C6OC)[C@H](C[C@H]1O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G10 compound treatment 9.5056904E7 -1.51E7 -0.86 9.5945429E7 -1.07E7 -0.66 -1.0767 -0.9912 1082254 SPBio_000448 OC(=O)CCNC(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G11 compound treatment 9.4753869E7 -1.54E7 -0.88 9.4864658E7 -1.18E7 -0.73 -1.1361 -0.9954 2060068 SPBio_000449 COC1C(O)C(O[C@H]2CC[C@]3(C=O)C4[C@@H](C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)OC(=O)C)OC(C)C1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G12 compound treatment 3.0406928E7 -7.98E7 -4.56 2.991042E7 -7.67E7 -4.73 -6.5677 -0.9998 1001284 SPBio_000450 CC(C)C1NC(=O)C(NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)NC5C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C6CCCC6C(=O)C(NC5=O)C(C)C)c4nc23)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCC7C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G13 compound treatment 9.2399515E7 -1.78E7 -1.02 9.4797819E7 -1.18E7 -0.73 -1.2342 -0.9869 3174249 SPBio_000451 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G14 compound treatment 4.8925296E7 -6.12E7 -3.5 4.9702233E7 -5.69E7 -3.51 -4.9567 -1.0 2069274 SPBio_000452 CC(O)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(C)c3C(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G15 compound treatment 9.2516629E7 -1.76E7 -1.01 9.4444189E7 -1.22E7 -0.75 -1.2448 -0.9896 2060088 SPBio_000453 COc1cc2ccc(=O)oc2c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G16 compound treatment 9.4134686E7 -1.6E7 -0.92 9.4262452E7 -1.24E7 -0.76 -1.1874 -0.9959 840 SPBio_000454 CCOc1ccc2ccccc2c1NC(=O)[C@H]3[C@H]4SC(C)(C)C(N4C3=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G17 compound treatment 9.4712406E7 -1.54E7 -0.88 9.7041528E7 -9600000.0 -0.59 -1.0429 -0.9811 2060292 SPBio_000455 CC1(C)[C@H](O)C[C@H](O)[C@@]2(C)C1C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G18 compound treatment 9.692755E7 -1.32E7 -0.76 9.6747483E7 -9900000.0 -0.61 -0.9662 -0.9943 1041649 SPBio_000456 CC(C)c1ccc(C)c(C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G19 compound treatment 1.00163338E8 -1.0E7 -0.57 9.9397259E7 -7250000.0 -0.45 -0.7199 -0.9926 3472730 SPBio_000457 CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G20 compound treatment 1.01836658E8 -8320000.0 -0.48 9.3831987E7 -1.28E7 -0.79 -0.8949 -0.9706 1001523 SPBio_000458 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G21 compound treatment 1.01156996E8 -9000000.0 -0.51 9.561549E7 -1.1E7 -0.68 -0.8446 -0.9906 3054130 SPBio_000459 CC(CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=C(CC[C@@]12C)C4(C)CC[C@H](OC(=O)C)C(C)(C)C4CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G22 compound treatment 1.10598879E8 439000.0 0.03 1.09611062E8 2970000.0 0.18 0.147 0.7966 2060420 SPBio_000460 CC(=O)O[C@@H]1CC2C(C)(C)[C@@H](O)CCC2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4C13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G23 mock treatment 1.01720113E8 -8440000.0 -0.48 9.7174362E7 -9470000.0 -0.58 -0.7539 -0.9955 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 G24 mock treatment 1.16731453E8 6570000.0 0.38 1.07707322E8 1060000.0 0.07 0.3119 0.8181 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H01 mock treatment 1.05244234E8 -4920000.0 -0.28 1.03176597E8 -3470000.0 -0.21 -0.3499 -0.9909 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H02 mock treatment 9.9450945E7 -1.07E7 -0.61 9.6596293E7 -1.0E7 -0.62 -0.8708 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H03 compound treatment 1.07887406E8 -2270000.0 -0.13 1.00501541E8 -6140000.0 -0.38 -0.3596 -0.8983 1235 SPBio_000461 CCOC(=O)CCCCCCCCCCCCC1CCC=C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H04 compound treatment 6.2753802E7 -4.74E7 -2.71 6.1484476E7 -4.52E7 -2.78 -3.8843 -0.9999 2565 SPBio_000462 COC1=CC(=O)OC1(O)C(=C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H05 compound treatment 9.853866E7 -1.16E7 -0.66 1.01347937E8 -5300000.0 -0.33 -0.7005 -0.9465 1384 SPBio_000463 COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H06 compound treatment 9.7778117E7 -1.24E7 -0.71 9.8505861E7 -8140000.0 -0.5 -0.8552 -0.9858 2060149 SPBio_000464 Cc1cc(O)c2C(=O)c3c(O)cccc3Cc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H07 compound treatment 9.7066084E7 -1.31E7 -0.75 9.565437E7 -1.1E7 -0.68 -1.0082 -0.9988 1044852 SPBio_000465 OC(=O)c1cc2cc(Cl)ccc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H08 compound treatment 9.2731874E7 -1.74E7 -1.0 8.8429154E7 -1.82E7 -1.12 -1.4983 -0.9982 715 SPBio_000466 COc1c2ccoc2c(OC)c3oc(C)cc(=O)c13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H09 compound treatment 9.5989589E7 -1.42E7 -0.81 9.725609E7 -9390000.0 -0.58 -0.9819 -0.9864 3078458 SPBio_000467 CCCCCC/C=C\CCCCCCCc1cccc(O)c1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H10 compound treatment 1.01572723E8 -8590000.0 -0.49 1.01958893E8 -4690000.0 -0.29 -0.5513 -0.9681 886 SPBio_000468 O[C@@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H11 compound treatment 8.0216132E7 -2.99E7 -1.71 8.5395826E7 -2.12E7 -1.31 -2.1363 -0.9913 710 SPBio_000469 CC(=O)OCC1=C(N2C(SC1)[C@H](NC(=O)CCCC(N)C(=O)O)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H12 compound treatment 8.2802001E7 -2.74E7 -1.56 8.5637915E7 -2.1E7 -1.29 -2.0213 -0.9956 1737132 SPBio_000470 COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c2c34)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H13 compound treatment 9.0464354E7 -1.97E7 -1.13 9.5555231E7 -1.11E7 -0.68 -1.2793 -0.9714 1001994 SPBio_000471 C[C@@H](N)[C@@H](O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H14 compound treatment 9.2939038E7 -1.72E7 -0.98 9.8272161E7 -8370000.0 -0.52 -1.0609 -0.9546 4895 SPBio_000472 C[n+]1cccc(c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H15 compound treatment 9.4155434E7 -1.6E7 -0.91 9.5616834E7 -1.1E7 -0.68 -1.1275 -0.9893 1004889 SPBio_000473 CC(=O)Nc1cccc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H16 compound treatment 2.8460556E7 -8.17E7 -4.67 2.7808118E7 -7.88E7 -4.86 -6.738 -0.9998 2060141 SPBio_000474 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccc(OC)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H17 compound treatment 9.5846043E7 -1.43E7 -0.82 9.5670194E7 -1.1E7 -0.68 -1.0568 -0.9955 954 SPBio_000475 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H18 compound treatment 9.4829103E7 -1.53E7 -0.88 9.5544401E7 -1.11E7 -0.68 -1.1034 -0.9925 1539748 SPBio_000476 COc1ccccc1c2coc3cc(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H19 compound treatment 9.661599E7 -1.35E7 -0.77 9.5730771E7 -1.09E7 -0.67 -1.0231 -0.9976 906 SPBio_000477 N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H20 compound treatment 9.3902726E7 -1.63E7 -0.93 9.2259344E7 -1.44E7 -0.89 -1.284 -0.9997 1010377 SPBio_000478 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H21 compound treatment 4.2572648E7 -6.76E7 -3.86 4.4207892E7 -6.24E7 -3.85 -5.4529 -1.0 2069291 SPBio_000479 COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H22 compound treatment 1.03668391E8 -6490000.0 -0.37 9.2693274E7 -1.4E7 -0.86 -0.8705 -0.9294 3055310 SPBio_000480 COc1c(O)cc2C(=O)O[C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]3c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H23 mock treatment 1.03699161E8 -6460000.0 -0.37 1.09447411E8 2800000.0 0.17 -0.139 -0.3409 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 H24 mock treatment 1.18621239E8 8460000.0 0.48 1.02762898E8 -3880000.0 -0.24 0.1727 0.3201 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I01 mock treatment 1.10342692E8 182000.0 0.01 1.0627695E8 -368000.0 -0.02 -0.0087 -0.3475 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I02 mock treatment 1.13321362E8 3160000.0 0.18 1.00873339E8 -5770000.0 -0.36 -0.1238 -0.3103 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I03 compound treatment 2.9324751E7 -8.08E7 -4.62 2.8984973E7 -7.77E7 -4.79 -6.6518 -0.9998 3173612 SPBio_000481 CC(=O)OC1CC2(O)C3CCC4CC(CC[C@]4(C)C3CC[C@]2(C)C1C5=CC(=O)OC5)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I04 compound treatment 1.06189834E8 -3970000.0 -0.23 1.04993219E8 -1650000.0 -0.1 -0.2325 -0.9346 2060151 SPBio_000482 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)[C@H](C[C@@H](OC(=O)C)C(C)(C)C5C[C@H](O)[C@]43C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I05 compound treatment 9.7487867E7 -1.27E7 -0.72 9.4236967E7 -1.24E7 -0.76 -1.053 -0.9996 2060096 SPBio_000483 CC(=O)O[C@@H]1CC(=O)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I06 compound treatment 9.0393158E7 -1.98E7 -1.13 8.9360541E7 -1.73E7 -1.07 -1.5522 -0.9996 2060396 SPBio_000484 OC[C@H]1O[C@@H](Oc2ccc(C(=O)/C=C/c3ccccc3)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I07 compound treatment 1.11670375E8 1510000.0 0.09 1.11726668E8 5080000.0 0.31 0.2825 0.8695 2060098 SPBio_000485 C[C@@]12CCC3C(CC[C@H]4C[C@@H](Cl)CC[C@@]43C)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I08 compound treatment 9.3961819E7 -1.62E7 -0.93 9.2795099E7 -1.38E7 -0.85 -1.2583 -0.9992 2060410 SPBio_000486 CC1(C)[C@H](O)CC(=O)[C@@]2(C)C1C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I09 compound treatment 8.6002084E7 -2.42E7 -1.38 8.4818531E7 -2.18E7 -1.35 -1.9277 -0.9999 2060114 SPBio_000487 COc1c2OCOc2cc3cc[n+](C)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I10 compound treatment 9.2823253E7 -1.73E7 -0.99 9.3678562E7 -1.3E7 -0.8 -1.2658 -0.9943 1503 SPBio_000488 Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I11 compound treatment 9.3044839E7 -1.71E7 -0.98 9.7258739E7 -9390000.0 -0.58 -1.1008 -0.9686 2060122 SPBio_000489 CC1(C)Oc2cc3oc(=O)ccc3cc2C=C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I12 compound treatment 3.0448396E7 -7.97E7 -4.56 2.979948E7 -7.68E7 -4.74 -6.5709 -0.9998 3077356 SPBio_000490 COc1cc(cc(OC)c1O)[C@H]2C3C(COC3=O)[C@H](O)c4cc5OCOc5cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I13 compound treatment 8.8040261E7 -2.21E7 -1.26 7.9176146E7 -2.75E7 -1.69 -2.0912 -0.9896 2060124 SPBio_000491 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCc3c(C(C)C)c(O)ccc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I14 compound treatment 9.1754123E7 -1.84E7 -1.05 9.0845783E7 -1.58E7 -0.97 -1.4325 -0.9993 1837 SPBio_000492 CS(=O)(=O)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I15 compound treatment 9.3203164E7 -1.7E7 -0.97 9.3659429E7 -1.3E7 -0.8 -1.2513 -0.9955 2060128 SPBio_000493 CO[C@@H]1C(OC(=O)C(C)C)[C@@]2(C)[C@@H](OC(=O)/C(=C(\OC)/C(C)C)/C2[C@@]34OC5(C)O[C@]14[C@]6(C)[C@@H](CC(=O)OC)C7(C)CC6(O5)[C@](OC)(C7OC(=O)C)[C@H]3OC)c8ccoc8 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I16 compound treatment 9.5211647E7 -1.49E7 -0.85 9.8865372E7 -7780000.0 -0.48 -0.9432 -0.9627 750 SPBio_000494 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1OC2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I17 compound treatment 8.3376658E7 -2.68E7 -1.53 8.994018E7 -1.67E7 -1.03 -1.8105 -0.9814 2060146 SPBio_000495 C[C@@]12CCC(=O)C=C2CCc3ccc(O)cc31 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I18 compound treatment 2.9166588E7 -8.1E7 -4.63 2.829817E7 -7.83E7 -4.83 -6.6881 -0.9998 1358 SPBio_000496 CN(CCCl)CCCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I19 compound treatment 9.4752172E7 -1.54E7 -0.88 9.1998742E7 -1.46E7 -0.9 -1.2611 -0.9999 2060157 SPBio_000497 CC(=O)C1CCC2C3CCC4C[C@H](O)CCC4(C)C3C[C@H](O)C12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I20 compound treatment 9.8721701E7 -1.14E7 -0.65 9.5034017E7 -1.16E7 -0.72 -0.9684 -0.999 1913604 SPBio_000498 OC(=O)CCCN1C(=O)c2cccc3cccc(C1=O)c23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I21 compound treatment 1.00247528E8 -9910000.0 -0.57 9.2649295E7 -1.4E7 -0.86 -1.0106 -0.9792 2060159 SPBio_000499 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)CCC(=O)C(C)(C)C5C[C@@H](OC(=O)C)[C@]43C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I22 compound treatment 1.0076604E8 -9390000.0 -0.54 9.1226321E7 -1.54E7 -0.95 -1.0517 -0.9635 3055336 SPBio_000500 Oc1ccc2sc(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I23 mock treatment 1.08910735E8 -1250000.0 -0.07 9.605142E7 -1.06E7 -0.65 -0.5123 -0.7798 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 I24 mock treatment 1.13705237E8 3540000.0 0.2 1.08398523E8 1750000.0 0.11 0.2197 0.9567 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J01 mock treatment 1.06630146E8 -3530000.0 -0.2 1.04143584E8 -2500000.0 -0.15 -0.2517 -0.9912 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J02 mock treatment 1.1001918E8 -141000.0 -0.01 1.01172946E8 -5470000.0 -0.34 -0.2442 -0.7238 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J03 compound treatment 9.9794084E7 -1.04E7 -0.59 9.8877972E7 -7770000.0 -0.48 -0.7575 -0.9944 3198315 SPBio_000501 COc1ccc(cc1F)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J04 compound treatment 1.01751292E8 -8410000.0 -0.48 9.8604787E7 -8040000.0 -0.5 -0.6903 -0.9999 989 SPBio_000502 NC(=N)NCCCCNC(=N)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J05 compound treatment 1.00959319E8 -9200000.0 -0.53 9.5660139E7 -1.1E7 -0.68 -0.8506 -0.9922 1439 SPBio_000503 CSCCC(N)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J06 compound treatment 6.1764829E7 -4.84E7 -2.77 6.6385058E7 -4.03E7 -2.48 -3.7106 -0.9985 2060167 SPBio_000504 COC(=O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J07 compound treatment 8.6071942E7 -2.41E7 -1.38 8.9126881E7 -1.75E7 -1.08 -1.737 -0.9928 3060196 SPBio_000505 COc1c(CN2CC[C@@H]3CCCN[C@@H]3C2)c(F)cc4c(=O)c(cn(C5CC5)c14)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J08 compound treatment 9.0527157E7 -1.96E7 -1.12 9.3589004E7 -1.31E7 -0.8 -1.3625 -0.9867 926 SPBio_000506 Oc1cccc2C(=O)c3cccc(O)c3C(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J09 compound treatment 9.4292491E7 -1.59E7 -0.91 9.7561079E7 -9080000.0 -0.56 -1.0372 -0.9732 1449108 SPBio_000507 Cc1ccc2c(Cl)cc(Cl)c(O)c2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J10 compound treatment 9.2341777E7 -1.78E7 -1.02 9.2431871E7 -1.42E7 -0.88 -1.3396 -0.9972 3055321 SPBio_000508 CC(CCC(=O)O)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J11 compound treatment 9.0238542E7 -1.99E7 -1.14 9.2198667E7 -1.44E7 -0.89 -1.4348 -0.9926 913 SPBio_000509 O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J12 compound treatment 9.5938245E7 -1.42E7 -0.81 9.8995222E7 -7650000.0 -0.47 -0.9082 -0.9665 1055132 SPBio_000510 COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J13 compound treatment 9.0516175E7 -1.96E7 -1.12 8.8867265E7 -1.78E7 -1.1 -1.5688 -0.9999 3480078 SPBio_000511 CC(C)N(CCC(c1ccccc1)c2cc(C)ccc2O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J14 compound treatment 9.126027E7 -1.89E7 -1.08 9.4659566E7 -1.2E7 -0.74 -1.2862 -0.9828 2069273 SPBio_000512 N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J15 compound treatment 3.5027202E7 -7.51E7 -4.29 3.5327795E7 -7.13E7 -4.4 -6.1449 -0.9999 2060469 SPBio_000513 C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)C)C3(C)C[C@H](O)C2C4(C)C=CC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J16 compound treatment 7.8579997E7 -3.16E7 -1.8 7.6671523E7 -3.0E7 -1.85 -2.5827 -0.9999 3177314 SPBio_000514 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CCC=C4C(=O)c3c(O)c2C=C1)[C@@](C/C=C(\C)/C(=O)O)(OC5(C)C)C(=O)O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J17 compound treatment 8.1787965E7 -2.84E7 -1.62 8.4389686E7 -2.23E7 -1.37 -2.1167 -0.9965 2069250 SPBio_000515 OCC(O)CC(O)CCCCCCCCCCCC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J18 compound treatment 9.5976485E7 -1.42E7 -0.81 9.675562E7 -9890000.0 -0.61 -1.0043 -0.9901 1084508 SPBio_000516 COc1ccc2cc3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J19 compound treatment 9.3616777E7 -1.65E7 -0.95 9.4728622E7 -1.19E7 -0.73 -1.188 -0.9922 3198316 SPBio_000517 C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(OCCO)cc(O)c4c3=O)c5ccc(OCCO)c(OCCO)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J20 compound treatment 1.00286415E8 -9870000.0 -0.56 9.7624327E7 -9020000.0 -0.56 -0.7922 -1.0 2069242 SPBio_000518 CC(=CCc1cc(cc(CC=C(C)C)c1O)C(=O)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J21 compound treatment 8.770168E7 -2.25E7 -1.28 8.48662E7 -2.18E7 -1.34 -1.8569 -0.9997 702 SPBio_000519 CCCCCC(=O)O[C@@]1(CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J22 compound treatment 9.8868437E7 -1.13E7 -0.65 9.0632215E7 -1.6E7 -0.99 -1.1543 -0.9788 3172733 SPBio_000520 Cc1c(C(=O)O)c(O)cc2C(=O)c3c(O)c(O)c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(O)c3C(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J23 mock treatment 1.11542717E8 1380000.0 0.08 1.07240108E8 595000.0 0.04 0.0818 0.9391 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 J24 mock treatment 1.13870096E8 3710000.0 0.21 1.0443829E8 -2210000.0 -0.14 0.0537 0.2133 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K01 mock treatment 1.12820338E8 2660000.0 0.15 1.09860593E8 3220000.0 0.2 0.2477 0.9914 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K02 mock treatment 1.16655536E8 6500000.0 0.37 1.03572174E8 -3070000.0 -0.19 0.1285 0.3085 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K03 compound treatment 1.10903123E8 743000.0 0.04 1.03717434E8 -2930000.0 -0.18 -0.0976 -0.5264 2060184 SPBio_000521 CC1CCc2c(O)c3c(=O)cc(C)oc3cc2OC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K04 compound treatment 1.0814032E8 -2020000.0 -0.12 1.03581076E8 -3060000.0 -0.19 -0.2152 -0.9721 3173993 SPBio_000522 O[C@H]1CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K05 compound treatment 1.02715802E8 -7440000.0 -0.43 9.8496824E7 -8150000.0 -0.5 -0.656 -0.9966 2060185 SPBio_000523 COc1ccc2[C@@H]3COc4cc(OC)ccc4[C@@H]3Oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K06 compound treatment 4.9947856E7 -6.02E7 -3.44 4.9081227E7 -5.76E7 -3.55 -4.9424 -0.9999 2069260 SPBio_000524 CC[C@@]1(O)C[C@H](O)c2c(O)c3C(=O)c4c(O)ccc(O)c4C(=O)c3cc2[C@H]1C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K07 compound treatment 2.8910721E7 -8.12E7 -4.64 2.8082259E7 -7.86E7 -4.84 -6.7079 -0.9998 2060186 SPBio_000525 CC(=O)OC1CCC2(C3CCC4(C)C(CCC54OC2=O)C6=CC(=O)OC6)C(O)(CCC35)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K08 compound treatment 9.8057454E7 -1.21E7 -0.69 9.9780336E7 -6860000.0 -0.42 -0.7883 -0.9722 2060406 SPBio_000526 COc1ccccc1/C=C\C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K09 compound treatment 9.5585884E7 -1.46E7 -0.83 9.74346E7 -9210000.0 -0.57 -0.9905 -0.9825 2060446 SPBio_000527 CC1(C)[C@@H](O)C=C[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K10 compound treatment 9.4504494E7 -1.57E7 -0.89 9.5478146E7 -1.12E7 -0.69 -1.1194 -0.9916 3174367 SPBio_000528 NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K11 compound treatment 9.2157743E7 -1.8E7 -1.03 9.6557271E7 -1.01E7 -0.62 -1.1672 -0.9709 2060390 SPBio_000529 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)C(OC(=O)C=C43)c5ccoc5)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K12 compound treatment 8.3998234E7 -2.62E7 -1.5 8.8070343E7 -1.86E7 -1.14 -1.8669 -0.9913 2060082 SPBio_000530 COC(=O)c1cc(OC)c(=O)c2c(OC)c(OC)ccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K13 compound treatment 9.1513521E7 -1.86E7 -1.07 9.1426396E7 -1.52E7 -0.94 -1.4169 -0.998 1111461 SPBio_000531 CC(=CCOc1c2occc2cc3ccc(=O)oc13)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K14 compound treatment 8.2656311E7 -2.75E7 -1.57 8.4327028E7 -2.23E7 -1.38 -2.0843 -0.9978 1054271 SPBio_000532 COc1ccc(cc1O)c2cc(=O)c3c(O)c(OC)c(OC)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K15 compound treatment 9.9987591E7 -1.02E7 -0.58 1.01092272E8 -5550000.0 -0.34 -0.6531 -0.9681 3174000 SPBio_000533 C[C@H]1[C@H]2[C@H](CC3C4CC[C@@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K16 compound treatment 5.3150845E7 -5.7E7 -3.26 5.289091E7 -5.38E7 -3.31 -4.6469 -1.0 1527 SPBio_000534 COc1cc2OC[C@H]3Oc4c5C[C@@H](Oc5ccc4C(=O)[C@H]3c2cc1OC)C(=C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K17 compound treatment 9.5907776E7 -1.43E7 -0.81 9.953142E7 -7110000.0 -0.44 -0.886 -0.9578 3173615 SPBio_000535 CCC(CCC(C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K18 compound treatment 1.02378183E8 -7780000.0 -0.44 1.03013588E8 -3630000.0 -0.22 -0.4728 -0.9495 1001 SPBio_000536 CN(C)CCOC(=O)COc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K19 compound treatment 9.687352E7 -1.33E7 -0.76 9.929709E7 -7350000.0 -0.45 -0.8572 -0.9695 2060206 SPBio_000537 CCC(CCC(C)C1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K20 compound treatment 1.04245075E8 -5920000.0 -0.34 9.985152E7 -6790000.0 -0.42 -0.5352 -0.9944 1065857 SPBio_000538 NC(CNC(=O)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K21 compound treatment 1.0875103E8 -1410000.0 -0.08 1.02228336E8 -4420000.0 -0.27 -0.2495 -0.8787 2069265 SPBio_000539 C[C@@]12CCC3C(CC[C@H]4CC(=O)CC[C@@]43C)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K22 compound treatment 3.0959736E7 -7.92E7 -4.53 2.8703503E7 -7.79E7 -4.8 -6.598 -0.9996 981 SPBio_000540 CCCCCCCCCCCCCCCC[n+]1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K23 mock treatment 1.04000033E8 -6160000.0 -0.35 9.788467E7 -8760000.0 -0.54 -0.6308 -0.9785 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 K24 mock treatment 1.15383667E8 5220000.0 0.3 1.1098956E8 4340000.0 0.27 0.4005 0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L01 mock treatment 1.11994845E8 1830000.0 0.1 1.01483533E8 -5160000.0 -0.32 -0.1508 -0.4503 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L02 mock treatment 9.4824842E7 -1.53E7 -0.88 9.2094221E7 -1.46E7 -0.9 -1.254 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L03 compound treatment 1.0596946E8 -4190000.0 -0.24 1.05014885E8 -1630000.0 -0.1 -0.2404 -0.9256 1009258 SPBio_000541 O=C1NC(=O)C(=O)C(=O)N1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L04 compound treatment 1.01634876E8 -8530000.0 -0.49 9.8575764E7 -8070000.0 -0.5 -0.6963 -0.9999 2069264 SPBio_000542 C[C@@]12CCC3C(CC[C@H]4C[C@@H](O)CC[C@@]43C)C2CC[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L05 compound treatment 1.02779668E8 -7380000.0 -0.42 1.00795199E8 -5850000.0 -0.36 -0.5533 -0.997 857 SPBio_000543 O=C(OCc1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L06 compound treatment 9.7838804E7 -1.23E7 -0.7 9.7074919E7 -9570000.0 -0.59 -0.9151 -0.9961 1009367 SPBio_000544 OC1=CC2=C3c4ccc(O)c(O)c4OCC3(O)CC2=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L07 compound treatment 2.89488E7 -8.12E7 -4.64 2.8093672E7 -7.86E7 -4.84 -6.7058 -0.9998 1021 SPBio_000545 CO[C@@H]1[C@@H](O)[C@H](C)O[C@@H](O[C@H]2CC[C@@]3(C)[C@H](CCC4C3CC[C@]5(C)C(CC[C@]45O)C6=CC(=O)OC6)C2)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L08 compound treatment 9.68238E7 -1.33E7 -0.76 1.00184579E8 -6460000.0 -0.4 -0.8206 -0.9542 991 SPBio_000546 CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L09 compound treatment 9.6140965E7 -1.4E7 -0.8 9.9062455E7 -7580000.0 -0.47 -0.8971 -0.9671 1147 SPBio_000547 COc1c2ccoc2cc3oc(=O)ccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L10 compound treatment 9.6672825E7 -1.35E7 -0.77 1.00209397E8 -6440000.0 -0.4 -0.8256 -0.9523 1000126 SPBio_000548 C[C@H](CCC(=O)O)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L11 compound treatment 2.8809119E7 -8.14E7 -4.65 2.954603E7 -7.71E7 -4.75 -6.6482 -0.9999 2060361 SPBio_000549 C/C=C(/C)\C(=O)O[C@@H]1[C@H](OC(=O)C)[C@]2(CO)[C@H](O)C[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(=O)O)[C@](C)(CO)C5CC[C@]43C)C2CC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L12 compound treatment 8.4122355E7 -2.6E7 -1.49 8.5683664E7 -2.1E7 -1.29 -1.9659 -0.9975 2060057 SPBio_000550 COC(=O)C[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L13 compound treatment 9.2914075E7 -1.72E7 -0.99 9.2847765E7 -1.38E7 -0.85 -1.2984 -0.9973 2060456 SPBio_000551 C[C@@H]1CC(Cl)CC[C@H]1C(=O)OC(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L14 compound treatment 9.1284471E7 -1.89E7 -1.08 9.4746733E7 -1.19E7 -0.73 -1.2814 -0.9823 2060413 SPBio_000552 CC(C)CCCC(C)[C@H]1CCC2C3CC[C@H]4CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L15 compound treatment 8.5695915E7 -2.45E7 -1.4 9.5804139E7 -1.08E7 -0.67 -1.4612 -0.9429 2060378 SPBio_000553 Oc1nc2cc(Cl)c(Cl)cc2nc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L16 compound treatment 9.179086E7 -1.84E7 -1.05 9.3230733E7 -1.34E7 -0.83 -1.3271 -0.993 1011559 SPBio_000554 Cc1cc(=O)oc2cc(O)c(O)cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L17 compound treatment 9.8581546E7 -1.16E7 -0.66 1.00369064E8 -6280000.0 -0.39 -0.7415 -0.9673 3055475 SPBio_000555 COc1ccc(/C=C/C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L18 compound treatment 8.7721386E7 -2.24E7 -1.28 9.2834084E7 -1.38E7 -0.85 -1.5088 -0.9802 2060366 SPBio_000556 CC1(C)C=CC(=O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L19 compound treatment 9.6538225E7 -1.36E7 -0.78 9.7238258E7 -9410000.0 -0.58 -0.9605 -0.9895 1187 SPBio_000557 C[C@@]12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CC[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L20 compound treatment 2.8612134E7 -8.15E7 -4.66 2.8231418E7 -7.84E7 -4.83 -6.7134 -0.9998 2060045 SPBio_000558 CC(=C)/C=C\1/C=CC(=O)C(=C1)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L21 compound treatment 9.1948174E7 -1.82E7 -1.04 9.5475069E7 -1.12E7 -0.69 -1.2229 -0.9799 1052338 SPBio_000559 COc1cc2C(C)NCCc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L22 compound treatment 9.8838962E7 -1.13E7 -0.65 9.4472102E7 -1.22E7 -0.75 -0.9881 -0.9973 3172727 SPBio_000560 CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L23 mock treatment 1.03843308E8 -6320000.0 -0.36 9.8326433E7 -8320000.0 -0.51 -0.6179 -0.9853 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 L24 mock treatment 1.16533293E8 6370000.0 0.36 1.07701583E8 1060000.0 0.07 0.3036 0.8205 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M01 mock treatment 1.24307074E8 1.41E7 0.81 1.21295537E8 1.47E7 0.9 1.2103 0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M02 mock treatment 1.16580472E8 6420000.0 0.37 1.08678756E8 2030000.0 0.13 0.3481 0.8977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M03 compound treatment 1.0973674E8 -424000.0 -0.02 1.0704732E8 402000.0 0.02 4.0E-4 0.012 2060155 SPBio_000561 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)[C@H](C[C@@H](OC(=O)C)C(C)(C)C5C[C@@H](O)[C@]43C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M04 compound treatment 3.0006558E7 -8.02E7 -4.58 2.9469584E7 -7.72E7 -4.76 -6.6031 -0.9998 2060215 SPBio_000562 CC1(C)C2C=C[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]2(C)C=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M05 compound treatment 3.5093509E7 -7.51E7 -4.29 3.5207402E7 -7.14E7 -4.4 -6.1474 -0.9999 1010376 SPBio_000563 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M06 compound treatment 2.981499E7 -8.03E7 -4.59 2.935166E7 -7.73E7 -4.76 -6.616 -0.9998 3173759 SPBio_000564 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(OC4O[C@@H]5COC(C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M07 compound treatment 1.01063406E8 -9100000.0 -0.52 9.9880384E7 -6760000.0 -0.42 -0.6625 -0.994 1326 SPBio_000565 CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M08 compound treatment 1.01150807E8 -9010000.0 -0.51 1.01696864E8 -4950000.0 -0.31 -0.5798 -0.9688 1015281 SPBio_000566 COc1cc(O)c(C(=O)C)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M09 compound treatment 9.6069407E7 -1.41E7 -0.81 9.9190243E7 -7450000.0 -0.46 -0.8944 -0.9646 1570 SPBio_000567 CCCC(C)C1(CC=C)C(=O)NC(=NC1=O)S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M10 compound treatment 7.713182E7 -3.3E7 -1.89 8.5777219E7 -2.09E7 -1.29 -2.2443 -0.9825 1473 SPBio_000568 CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M11 compound treatment 8.4688424E7 -2.55E7 -1.46 8.1085789E7 -2.56E7 -1.58 -2.1435 -0.9992 2060408 SPBio_000569 COC(=O)C[C@H]1C(C)(C)[C@H](C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M12 compound treatment 7.395716E7 -3.62E7 -2.07 7.7878107E7 -2.88E7 -1.77 -2.7169 -0.997 2069338 SPBio_000570 CC(=O)O[C@@H]1Cc2c(OC(=O)C)cc(OC(=O)C)cc2O[C@@H]1c3ccc(OC(=O)C)c(OC(=O)C)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M13 compound treatment 9.3915437E7 -1.62E7 -0.93 9.5604293E7 -1.1E7 -0.68 -1.1377 -0.9883 1050335 SPBio_000571 COc1cc(OC)c(C=O)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M14 compound treatment 5.5681063E7 -5.45E7 -3.11 5.6691786E7 -5.0E7 -3.08 -4.379 -1.0 1950 SPBio_000572 Oc1cc2oc(cc(=O)c2c(O)c1O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M15 compound treatment 9.6038793E7 -1.41E7 -0.81 9.7258047E7 -9390000.0 -0.58 -0.9798 -0.9867 3198311 SPBio_000573 Cc1cc(O)c(C=O)c2Oc3c(C)c(C(=O)O)c(O)c(COC(=O)/C=C/C(=O)O)c3OC(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M16 compound treatment 9.6097823E7 -1.41E7 -0.8 9.9455395E7 -7190000.0 -0.44 -0.8817 -0.9607 832189 SPBio_000574 CC(=O)CC(=O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M17 compound treatment 2.8647376E7 -8.15E7 -4.66 2.7840547E7 -7.88E7 -4.86 -6.729 -0.9998 1597 SPBio_000575 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M18 compound treatment 1.00523734E8 -9640000.0 -0.55 9.7822891E7 -8820000.0 -0.54 -0.774 -1.0 780 SPBio_000576 CC(C)NNC(=O)c1ccncc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M19 compound treatment 6.5843515E7 -4.43E7 -2.53 7.325433E7 -3.34E7 -2.06 -3.2464 -0.9947 2060116 SPBio_000577 CCC(=O)OC1[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@](C)([C@@H](CC(=O)OC)C1(C)C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M20 compound treatment 9.6014496E7 -1.41E7 -0.81 9.7702973E7 -8940000.0 -0.55 -0.9614 -0.9826 3173091 SPBio_000578 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)C(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3OC4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M21 compound treatment 1.01455784E8 -8700000.0 -0.5 1.04441019E8 -2200000.0 -0.14 -0.4478 -0.8684 1071570 SPBio_000579 CCOC(=O)c1c(C)cc(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M22 compound treatment 9.8982111E7 -1.12E7 -0.64 1.02436135E8 -4210000.0 -0.26 -0.6352 -0.9212 3172862 SPBio_000580 O=c1cccc2C3CNC[C@@H](C3)Cn21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M23 mock treatment 9.976009E7 -1.04E7 -0.59 1.02075208E8 -4570000.0 -0.28 -0.6195 -0.9418 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 M24 mock treatment 1.18065484E8 7910000.0 0.45 1.11867758E8 5220000.0 0.32 0.5471 0.9862 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N01 mock treatment 1.2475546E8 1.46E7 0.83 1.19009844E8 1.24E7 0.76 1.1288 0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N02 mock treatment 1.11697252E8 1540000.0 0.09 1.07551907E8 907000.0 0.06 0.1016 0.9762 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N03 compound treatment 1.07253369E8 -2910000.0 -0.17 1.01331563E8 -5310000.0 -0.33 -0.3491 -0.9505 3471725 SPBio_000581 CC1(C)SC2C(NC(=O)C(N=C)c3ccccc3)C(=O)N2C1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N04 compound treatment 1.09192411E8 -968000.0 -0.06 9.8983873E7 -7660000.0 -0.47 -0.3731 -0.7846 3173106 SPBio_000582 COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2c(C)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N05 compound treatment 1.01436379E8 -8720000.0 -0.5 9.7580838E7 -9060000.0 -0.56 -0.7476 -0.9984 3474304 SPBio_000583 COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N06 compound treatment 9.7748813E7 -1.24E7 -0.71 9.9054902E7 -7590000.0 -0.47 -0.8324 -0.9796 2069253 SPBio_000584 CC(C)/C(=C/1\C2[C@@]34OC5(C)O[C@@]4([C@H](O)C(O)[C@@]2(C)[C@@H](OC1=O)c6ccoc6)[C@]7(C)[C@@H](CC(=O)O)C8(C)CC7(O5)[C@](O)(C8O)[C@H]3O)/O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N07 compound treatment 5.2977835E7 -5.72E7 -3.27 3.906469E7 -6.76E7 -4.17 -5.2566 -0.9928 1001621 SPBio_000585 Oc1cc(cc(O)c1O)C(=O)Oc2cc(cc(O)c2O)C(=O)OC[C@H]3O[C@H](OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)[C@H](OC(=O)c6cc(O)c(O)c(OC(=O)c7cc(O)c(O)c(O)c7)c6)[C@@H](OC(=O)c8cc(O)c(O)c(OC(=O)c9cc(O)c(O)c(O)c9)c8)[C@@H]3OC(=O)c%10cc(O)c(O)c(OC(=O)c%11cc(O)c(O)c(O)c%11)c%10 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N08 compound treatment 3.4953672E7 -7.52E7 -4.3 3.4165197E7 -7.25E7 -4.47 -6.1985 -0.9998 1101 SPBio_000586 CCCC1O[C@@H]2CC3C4CCC5=CC(=O)C=CC5(C)C4[C@@H](O)CC3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N09 compound treatment 9.9437216E7 -1.07E7 -0.61 9.7282688E7 -9360000.0 -0.58 -0.8414 -0.9995 789 SPBio_000587 C[N+]1(C)C2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N10 compound treatment 9.5735905E7 -1.44E7 -0.82 9.52255E7 -1.14E7 -0.7 -1.0807 -0.9969 3173360 SPBio_000588 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4CCCC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N11 compound treatment 9.8745212E7 -1.14E7 -0.65 9.2912604E7 -1.37E7 -0.85 -1.0599 -0.9917 2060466 SPBio_000589 OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N12 compound treatment 9.7176398E7 -1.3E7 -0.74 9.7617673E7 -9030000.0 -0.56 -0.9182 -0.9899 2060311 SPBio_000590 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4CC(=O)CC[C@]4(C)C3C=C[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N13 compound treatment 2.8507534E7 -8.17E7 -4.67 2.7934648E7 -7.87E7 -4.85 -6.7306 -0.9998 3172984 SPBio_000591 COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(=C(O)C(=O)C=C5[C@]4(C)CC[C@@]3(C)[C@@H]2C1)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N14 compound treatment 9.3445801E7 -1.67E7 -0.96 9.5359861E7 -1.13E7 -0.7 -1.1674 -0.9879 2060399 SPBio_000592 CC(C)CCCC(C)[C@H]1CCC2C3C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N15 compound treatment 9.2707208E7 -1.75E7 -1.0 9.6960874E7 -9680000.0 -0.6 -1.1274 -0.9699 911 SPBio_000593 CCCCCC(C)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N16 compound treatment 2.8568184E7 -8.16E7 -4.66 2.7791891E7 -7.89E7 -4.86 -6.7344 -0.9998 2060079 SPBio_000594 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N17 compound treatment 8.6970013E7 -2.32E7 -1.33 1.04650714E8 -1990000.0 -0.12 -1.0241 -0.7694 1001451 SPBio_000595 Cc1cc(C)cc(OCC2CNC(=O)O2)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N18 compound treatment 6.7912375E7 -4.22E7 -2.41 6.1329519E7 -4.53E7 -2.79 -3.6825 -0.9974 1600 SPBio_000596 CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N19 compound treatment 9.0366324E7 -1.98E7 -1.13 1.00396698E8 -6250000.0 -0.39 -1.0723 -0.8973 1470 SPBio_000597 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N20 compound treatment 9.836825E7 -1.18E7 -0.67 9.8032145E7 -8610000.0 -0.53 -0.852 -0.993 2060071 SPBio_000598 CCOC(=O)c1c(C)cc(O)c(C=O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N21 compound treatment 9.4730851E7 -1.54E7 -0.88 9.4710616E7 -1.19E7 -0.74 -1.1437 -0.9959 399 SPBio_000599 Nc1nc2ccc(OC(F)(F)F)cc2s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N22 compound treatment 3.0062909E7 -8.01E7 -4.58 2.882769E7 -7.78E7 -4.8 -6.6288 -0.9997 3172726 SPBio_000600 C[C@]12C3CCC(O3)[C@]2(C)C(=O)OC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N23 mock treatment 9.7682211E7 -1.25E7 -0.71 1.02684355E8 -3960000.0 -0.24 -0.6769 -0.898 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 N24 mock treatment 1.13734378E8 3570000.0 0.2 1.14374514E8 7730000.0 0.48 0.4813 0.9285 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O01 mock treatment 1.16382802E8 6220000.0 0.36 1.09399914E8 2750000.0 0.17 0.3715 0.9428 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O02 mock treatment 9.9843061E7 -1.03E7 -0.59 9.6787804E7 -9860000.0 -0.61 -0.8466 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O03 compound treatment 9.4010882E7 -1.61E7 -0.92 9.6427401E7 -1.02E7 -0.63 -1.098 -0.9826 2060228 SPBio_000601 COC(=O)CC1[C@@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]53O[C@]2(O)[C@@H]([C@H]5OC(=O)C)C(OC(=O)C)C1(C)C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O04 compound treatment 9.7789032E7 -1.24E7 -0.71 9.6856304E7 -9790000.0 -0.6 -0.9266 -0.9969 1129781 SPBio_000602 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(OC)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O05 compound treatment 3.0570455E7 -7.96E7 -4.55 2.9193829E7 -7.75E7 -4.77 -6.5923 -0.9997 2060178 SPBio_000603 CC12C[C@@H](O)C3C(CCC4CC(O)CCC43C)C2(O)CCC1C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O06 compound treatment 9.8888797E7 -1.13E7 -0.64 9.7706861E7 -8940000.0 -0.55 -0.8451 -0.997 2060451 SPBio_000604 CC(C)(O)CC[C@@H](O)[C@](C)(O)C1CC[C@@]2(O)C3=CC(=O)C4C[C@@H](O)[C@@H](O)C[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O07 compound treatment 9.8120426E7 -1.2E7 -0.69 9.7029117E7 -9620000.0 -0.59 -0.9057 -0.9972 2060209 SPBio_000605 COc1cc2OCC3Oc4c(C(=O)O)c(O)ccc4C(=O)C3(O)c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O08 compound treatment 9.5394506E7 -1.48E7 -0.84 9.6610013E7 -1.0E7 -0.62 -1.0341 -0.9883 3174226 SPBio_000606 CC[N+](C)(C)Cc1ccc(Br)cc1.Cc1ccc(cc1)S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O09 compound treatment 7.6314568E7 -3.38E7 -1.93 8.5584791E7 -2.11E7 -1.3 -2.2858 -0.9812 2060130 SPBio_000607 COc1ccc(cc1)[C@@H](C)C(=O)c2ccc(O)cc2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O10 compound treatment 9.077708E7 -1.94E7 -1.11 9.4970068E7 -1.17E7 -0.72 -1.2922 -0.9782 3263 SPBio_000608 CNC(C)(C)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O11 compound treatment 8.3459636E7 -2.67E7 -1.53 9.217019E7 -1.45E7 -0.89 -1.71 -0.9673 2060064 SPBio_000609 CCC(C)C(=O)OC1[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@](C)([C@@H](CC(=O)OC)C1(C)C)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O12 compound treatment 9.6289737E7 -1.39E7 -0.79 1.02123066E8 -4520000.0 -0.28 -0.7576 -0.9016 1231 SPBio_000610 CC(C)C[C@H](NC(=O)C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O13 compound treatment 8.861315E7 -2.15E7 -1.23 9.294056E7 -1.37E7 -0.84 -1.4681 -0.9831 2060078 SPBio_000611 COc1cc2OC[C@H]3Oc4c(CC=C(C)C)c(O)ccc4C(=O)[C@H]3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O14 compound treatment 6.0125386E7 -5.0E7 -2.86 6.7497419E7 -3.91E7 -2.41 -3.7284 -0.9964 2060471 SPBio_000612 C[C@H]1[C@H]2[C@H](OC1=O)[C@@H]3C(=CC(=O)C3=C(C)C[C@@H]2O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O15 compound treatment 9.064519E7 -1.95E7 -1.12 9.2815323E7 -1.38E7 -0.85 -1.3915 -0.9912 1009294 SPBio_000613 Oc1ccc2C(=O)c3ccccc3C(=O)c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O16 compound treatment 3.4080576E7 -7.61E7 -4.35 3.0512994E7 -7.61E7 -4.69 -6.393 -0.9993 3055313 SPBio_000614 CC(C)[C@@]12O[C@H]2[C@@H]3O[C@]34[C@]5(O[C@H]5C[C@H]6C7=C(CC[C@@]64C)C(=O)OC7)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O17 compound treatment 9.3426134E7 -1.67E7 -0.96 9.842267E7 -8220000.0 -0.51 -1.0347 -0.9559 1112402 SPBio_000615 COc1ccc2ccc(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O18 compound treatment 8.42142E7 -2.59E7 -1.48 9.5545003E7 -1.11E7 -0.68 -1.5324 -0.9383 2559 SPBio_000616 CC(=O)O[Cd]OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O19 compound treatment 2.9845959E7 -8.03E7 -4.59 3.0798354E7 -7.58E7 -4.68 -6.5517 -1.0 1016781 SPBio_000617 OC(=O)c1cc(O)c(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O20 compound treatment 8.494107E7 -2.52E7 -1.44 9.3087574E7 -1.36E7 -0.84 -1.6101 -0.9664 1120 SPBio_000618 Oc1ccc(cc1[N+](=O)[O-])[As](=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O21 compound treatment 9.6358959E7 -1.38E7 -0.79 1.03972635E8 -2670000.0 -0.16 -0.6742 -0.8367 2060044 SPBio_000619 CC(=O)Oc1cc(cc(OC(=O)C)c1OC(=O)C)c2coc3cc(OC(=O)C)c(OC(=O)C)c(OC(=O)C)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O22 compound treatment 4.6783161E7 -6.34E7 -3.62 4.5438588E7 -6.12E7 -3.77 -5.2291 -0.9998 2060156 SPBio_000620 CCC(C)C(O)C(=O)O[C@H]1[C@H](OC=O)C(C(=C)C2(O)C(=O)C[C@@H](c3ccoc3)[C@]12C)[C@]4(C)C(CC(=O)OC)[C@@](C)(COC(=O)C)OC(=O)C[C@@H]4OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O23 mock treatment 9.8553779E7 -1.16E7 -0.66 1.03419448E8 -3230000.0 -0.2 -0.6096 -0.8804 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 O24 mock treatment 1.09604749E8 -556000.0 -0.03 1.15390946E8 8750000.0 0.54 0.3588 0.6643 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P01 mock treatment 1.18313532E8 8150000.0 0.47 1.13509298E8 6860000.0 0.42 0.6287 0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P02 mock treatment 1.12897086E8 2740000.0 0.16 1.10449106E8 3800000.0 0.23 0.2764 0.9806 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P03 compound treatment 1.06963933E8 -3200000.0 -0.18 9.5664059E7 -1.1E7 -0.68 -0.6078 -0.8669 1001332 SPBio_000621 CN(C)CCC[C@]1(OCc2cc(C#N)ccc21)c3ccc(F)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P04 compound treatment 1.01669339E8 -8490000.0 -0.49 9.9772499E7 -6870000.0 -0.42 -0.6427 -0.9977 2060433 SPBio_000622 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O[C@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P05 compound treatment 2.8943187E7 -8.12E7 -4.64 2.8426871E7 -7.82E7 -4.82 -6.6915 -0.9998 1228 SPBio_000623 CC[Hg]Sc1ccccc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P06 compound treatment 3.0600499E7 -7.96E7 -4.55 2.9210076E7 -7.74E7 -4.77 -6.5904 -0.9997 336 SPBio_000624 COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P07 compound treatment 6.5351701E7 -4.48E7 -2.56 6.5015562E7 -4.16E7 -2.57 -3.6254 -1.0 1210108 SPBio_000625 Oc1ccc2cccc(O)c(=O)c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P08 compound treatment 9.67201E7 -1.34E7 -0.77 1.02169325E8 -4480000.0 -0.28 -0.7382 -0.9045 1043 SPBio_000626 O[Hg]c1c(O)c(Br)cc2c(c3ccccc3C(=O)O)c4cc(Br)c(=O)cc4oc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P09 compound treatment 1.01158116E8 -9000000.0 -0.51 1.03320773E8 -3320000.0 -0.2 -0.5087 -0.9186 932 SPBio_000627 NCCCCC(N)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCCN)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P10 compound treatment 9.8903787E7 -1.13E7 -0.64 9.8247803E7 -8400000.0 -0.52 -0.8209 -0.9942 2060324 SPBio_000628 CC12CC[C@@H]3[C@H](CC3(C)C)C(=C)CC2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P11 compound treatment 1.01191221E8 -8970000.0 -0.51 1.05891336E8 -754000.0 -0.05 -0.3953 -0.768 1032444 SPBio_000629 CC(=O)Oc1c(C)cccc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P12 compound treatment 9.1710283E7 -1.85E7 -1.05 1.06573523E8 -71500.0 0.0 -0.7487 -0.7101 2060355 SPBio_000630 CC1=C(C=C)/C(=C/c2[nH]c(Cc3[nH]c(\C=C\4/NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)/NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P13 compound treatment 9.8294875E7 -1.19E7 -0.68 1.07581894E8 937000.0 0.06 -0.4387 -0.6446 1578 SPBio_000631 CC1=NCCc2c1[nH]c3cc(O)ccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P14 compound treatment 9.2914904E7 -1.72E7 -0.99 9.4776301E7 -1.19E7 -0.73 -1.2143 -0.9892 3174615 SPBio_000632 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P15 compound treatment 8.786096E7 -2.23E7 -1.27 1.00587421E8 -6060000.0 -0.37 -1.1652 -0.8774 3173998 SPBio_000633 CC(=O)O[C@@H]1C2CC[C@@H]3C1(C[C@@]2(C)O)C[C@@H](O)[C@@]4(O)[C@@H](C[C@H](O)C4(C)C)[C@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P16 compound treatment 8.9103161E7 -2.11E7 -1.2 9.8505502E7 -8140000.0 -0.5 -1.2058 -0.9248 3173217 SPBio_000634 CCN1C[C@@]2(COC)C3[C@@H](OC)[C@H]4[C@@H]1[C@@]3(C5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)C5[C@]4(OC(=O)C)[C@@H](O)[C@@H]6OC)C(C[C@H]2O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P17 compound treatment 9.3973176E7 -1.62E7 -0.93 1.04427821E8 -2220000.0 -0.14 -0.7508 -0.8029 2069287 SPBio_000635 CCCCCC1C(CC(=O)OC)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P18 compound treatment 4.8153901E7 -6.2E7 -3.54 4.6307335E7 -6.03E7 -3.72 -5.1358 -0.9997 425 SPBio_000636 Oc1ccc(cc1)c2coc3cc(O)cc(O)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P19 compound treatment 9.4752565E7 -1.54E7 -0.88 1.08143602E8 1500000.0 0.09 -0.5573 -0.6295 1229 SPBio_000637 CC(=O)N[C@H]1[C@@H](O)C[C@](O)(O[C@@H]1C(O)[C@H](O)CO)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P20 compound treatment 9.3662444E7 -1.65E7 -0.94 1.06869122E8 224000.0 0.01 -0.657 -0.6967 2060371 SPBio_000638 COC(=O)C[C@H]1C(C)(C)C2(O)OC34CC2C(=O)[C@]1(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C35)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P21 compound treatment 1.02955658E8 -7200000.0 -0.41 1.17521554E8 1.09E7 0.67 0.1829 0.2325 2070 SPBio_000639 COc1ccc(cc1)c2coc3cc(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P22 compound treatment 1.01624444E8 -8540000.0 -0.49 1.04321759E8 -2320000.0 -0.14 -0.4462 -0.8777 1000253 SPBio_000640 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P23 mock treatment 1.10642167E8 482000.0 0.03 1.10955469E8 4310000.0 0.27 0.2074 0.7762 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2159 P24 mock treatment 1.20418212E8 1.03E7 0.59 1.20659726E8 1.4E7 0.86 1.0254 0.9822 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A01 mock treatment 1.16219181E8 1.34E7 0.76 1.24258199E8 2.22E7 1.37 1.5084 0.962 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A02 mock treatment 1.06355564E8 3500000.0 0.2 1.15195182E8 1.31E7 0.81 0.7148 0.8561 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A03 compound treatment 1.00306082E8 -2540000.0 -0.15 1.1179028E8 9740000.0 0.6 0.3219 0.5209 2060176 SPBio_000641 CC(=O)/C=C\[C@H]1[C@](C)(O)CCC2C(C)(C)CCC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A04 compound treatment 1.1517348E8 1.23E7 0.7 1.18776685E8 1.67E7 1.03 1.2272 0.9827 3057756 SPBio_000642 C1CCN2C[C@H]3C[C@@H](CN4CCCC[C@H]34)[C@@H]2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A05 compound treatment 7.7551995E7 -2.53E7 -1.45 8.9007329E7 -1.3E7 -0.8 -1.5907 -0.9616 1016582 SPBio_000643 COc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A06 compound treatment 1.13665139E8 1.08E7 0.62 1.12053037E8 1.0E7 0.62 0.8732 1.0 1151 SPBio_000644 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A07 compound treatment 9.1775847E7 -1.11E7 -0.63 1.01847021E8 -199000.0 -0.01 -0.4562 -0.7207 3054108 SPBio_000645 Nc1nc2ncc(=O)[nH]c2c(=O)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A08 compound treatment 9.6145329E7 -6710000.0 -0.38 1.04554645E8 2510000.0 0.15 -0.1616 -0.3912 1023016 SPBio_000646 COc1ccc2ccc(=O)oc2c1CC=C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A09 compound treatment 6.4411998E7 -3.84E7 -2.2 8.8685407E7 -1.34E7 -0.82 -2.1358 -0.9103 2060374 SPBio_000647 CCC(C)C(OC(=O)C)C(=O)O[C@H]1[C@H](O)C2[C@@]3(C)C=CC(=O)C(C)(C)C3C[C@@H](OC(=O)C(O)C(C)C)[C@@]2(C)[C@]45O[C@@H]5C[C@@H](c6ccoc6)[C@]14C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A10 compound treatment 2.7461546E7 -7.54E7 -4.31 2.8798926E7 -7.32E7 -4.52 -6.2393 -0.9997 2549 SPBio_000648 C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A11 compound treatment 9.3293388E7 -9560000.0 -0.55 9.8211605E7 -3830000.0 -0.24 -0.5534 -0.9298 2069225 SPBio_000649 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c5c(=O)c(O)cc(cc45)[C@H]6Oc7cc(O)cc(O)c7C[C@H]6OC(=O)c8cc(O)c(O)c(O)c8 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A12 compound treatment 1.01319072E8 -1530000.0 -0.09 1.01968943E8 -77300.0 0.0 -0.0653 -0.7445 3059440 SPBio_000650 OC(=O)C1CC(CN2CCCCC12)[C@@H]3CCCCN3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A13 compound treatment 8.5610006E7 -1.72E7 -0.99 9.4921708E7 -7120000.0 -0.44 -1.0073 -0.9337 2546 SPBio_000651 COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A14 compound treatment 9.7004763E7 -5850000.0 -0.33 9.9647086E7 -2400000.0 -0.15 -0.3408 -0.9328 2060439 SPBio_000652 COC1=C(OC)C(=O)C(=C(C)C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC\C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A15 compound treatment 9.2586968E7 -1.03E7 -0.59 9.9897987E7 -2150000.0 -0.13 -0.5084 -0.8455 3078460 SPBio_000653 CO/N=C(\C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)/C=C\c3scnc3C)/c4csc(N)n4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A16 compound treatment 9.6991481E7 -5860000.0 -0.33 1.0655139E8 4510000.0 0.28 -0.0404 -0.0929 1307902 SPBio_000654 CN1CCCCC1c2ccc(nc2)c3cccnc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A17 compound treatment 9.9734895E7 -3120000.0 -0.18 1.00698559E8 -1350000.0 -0.08 -0.1847 -0.9398 2575 SPBio_000655 CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A18 compound treatment 1.12685393E8 9830000.0 0.56 1.14577754E8 1.25E7 0.77 0.9437 0.9878 3078270 SPBio_000656 CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A19 compound treatment 8.491983E7 -1.79E7 -1.02 9.7417838E7 -4630000.0 -0.29 -0.9264 -0.8709 3480341 SPBio_000657 CN1CCCC(CC1)n2nc(Cc3ccc(Cl)cc3)c4ccccc4c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A20 compound treatment 1.04031761E8 1180000.0 0.07 1.1268527E8 1.06E7 0.66 0.5115 0.7758 1204574 SPBio_000658 COc1c(oc2cc3oc(=O)ccc3cc12)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A21 compound treatment 3.406482E7 -6.88E7 -3.93 4.9417079E7 -5.26E7 -3.24 -5.0738 -0.9954 1351 SPBio_000659 Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A22 compound treatment 1.05468157E8 2620000.0 0.15 1.1294433E8 1.09E7 0.67 0.5808 0.8439 1008178 SPBio_000660 COc1cc(C)c(C(=O)Oc2cc(C)c(C(=O)O)c(O)c2C)c(OC)c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A23 mock treatment 1.14866846E8 1.2E7 0.69 1.21966326E8 1.99E7 1.23 1.3539 0.9623 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 A24 mock treatment 1.22525508E8 1.97E7 1.12 1.33322517E8 3.13E7 1.93 2.1584 0.9671 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B01 mock treatment 1.21373381E8 1.85E7 1.06 1.19227903E8 1.72E7 1.06 1.4975 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B02 mock treatment 9.9144653E7 -3710000.0 -0.21 1.00576665E8 -1470000.0 -0.09 -0.2138 -0.9282 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B03 compound treatment 7.163248E7 -3.12E7 -1.78 8.2298248E7 -1.97E7 -1.22 -2.1224 -0.9826 2069255 SPBio_000661 Oc1cc(cc(O)c1O)c2coc3cc(O)c(O)c(O)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B04 compound treatment 8.0241856E7 -2.26E7 -1.29 8.7219806E7 -1.48E7 -0.91 -1.5599 -0.9856 2060101 SPBio_000662 COc1ccc(cc1OC)[C@H]2Oc3c(I)c(OC)cc(OC)c3C[C@@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B05 compound treatment 9.9863877E7 -2990000.0 -0.17 9.8231355E7 -3810000.0 -0.24 -0.287 -0.9876 901 SPBio_000663 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B06 compound treatment 9.3154182E7 -9700000.0 -0.55 9.5498571E7 -6550000.0 -0.4 -0.6773 -0.9879 910 SPBio_000664 CN1CC(CNC(=O)OCc2ccccc2)C[C@@H]3C1Cc4cn(C)c5cccc3c45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B07 compound treatment 9.8809859E7 -4040000.0 -0.23 9.8807844E7 -3240000.0 -0.2 -0.3045 -0.9974 1315 SPBio_000665 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B08 compound treatment 9.6303837E7 -6550000.0 -0.37 9.3068994E7 -8980000.0 -0.55 -0.6559 -0.9818 683 SPBio_000666 Cc1ncc([N+](=O)[O-])n1CCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B09 compound treatment 8.3501832E7 -1.93E7 -1.11 9.5186791E7 -6860000.0 -0.42 -1.0809 -0.913 2069270 SPBio_000667 CC(C)CCCC(C)C1CCC2C3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B10 compound treatment 1.02643093E8 -208000.0 -0.01 9.3873909E7 -8170000.0 -0.5 -0.3646 -0.7236 3059437 SPBio_000668 OC[C@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B11 compound treatment 8.3201562E7 -1.96E7 -1.12 8.7994048E7 -1.41E7 -0.87 -1.4066 -0.9918 1044412 SPBio_000669 Oc1cc2ccccc2oc1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B12 compound treatment 1.02434301E8 -416000.0 -0.02 9.3312996E7 -8730000.0 -0.54 -0.3975 -0.7376 1090 SPBio_000670 CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B13 compound treatment 7.3829746E7 -2.9E7 -1.66 7.7509183E7 -2.45E7 -1.51 -2.2423 -0.9989 3198326 SPBio_000671 O[C@@H]1O[C@H](COC(=O)CC[N+](=O)[O-])[C@@H](OC(=O)CC[N+](=O)[O-])[C@H](OC(=O)CC[N+](=O)[O-])[C@H]1OC(=O)CC[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B14 compound treatment 6.9304628E7 -3.35E7 -1.92 7.049241E7 -3.16E7 -1.95 -2.731 -1.0 1259 SPBio_000672 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B15 compound treatment 4.1620792E7 -6.12E7 -3.5 4.4793907E7 -5.73E7 -3.53 -4.9699 -1.0 3177521 SPBio_000673 COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](OC(=O)C)c4cc5OCOc5cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B16 compound treatment 6.0924543E7 -4.19E7 -2.4 7.2055373E7 -3.0E7 -1.85 -3.0016 -0.9918 2551 SPBio_000674 COc1cc(NC(C)CCCN)c2ncccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B17 compound treatment 9.1171783E7 -1.17E7 -0.67 9.5309489E7 -6740000.0 -0.42 -0.7656 -0.9739 1050602 SPBio_000675 COc1ccc(CC(=O)c2ccc(O)cc2O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B18 compound treatment 2.6496015E7 -7.64E7 -4.36 2.7908672E7 -7.41E7 -4.57 -6.3172 -0.9997 763 SPBio_000676 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B19 compound treatment 9.9552517E7 -3300000.0 -0.19 1.00661974E8 -1380000.0 -0.09 -0.1936 -0.9358 2069259 SPBio_000677 C[C@@]12CCC3C(CC[C@H]4C[C@H](O)CC[C@@]43C)C2CC[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B20 compound treatment 1.07410697E8 4560000.0 0.26 1.12161537E8 1.01E7 0.62 0.6252 0.9251 368 SPBio_000678 CC/C(=C(\c1ccccc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B21 compound treatment 9.4710287E7 -8140000.0 -0.47 1.01261337E8 -785000.0 -0.05 -0.3632 -0.7765 3172708 SPBio_000679 CCC(C)C(=O)O[C@H]1[C@H](O)C2C(CN3CC(C)CCC3[C@@]2(C)O)C4C[C@]5(O[C@@]6(O)C7C(OC(=O)C)[C@@H](OC(=O)C)C5[C@@]41O)[C@@]7(C)CCC6OC(=O)C(C)(O)C(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B22 compound treatment 4.1404008E7 -6.14E7 -3.51 4.2449907E7 -5.96E7 -3.67 -5.0809 -0.9997 3198420 SPBio_000680 CC[C@]1(O)CC2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@H]7[C@@]86CCN9CC=C[C@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B23 mock treatment 1.07728179E8 4880000.0 0.28 1.04697243E8 2650000.0 0.16 0.3127 0.9676 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 B24 mock treatment 1.14014699E8 1.12E7 0.64 1.21132776E8 1.91E7 1.18 1.2831 0.9587 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C01 mock treatment 1.02217909E8 -633000.0 -0.04 1.04116752E8 2070000.0 0.13 0.0647 0.4876 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C02 mock treatment 9.1407648E7 -1.14E7 -0.65 9.4882754E7 -7160000.0 -0.44 -0.7747 -0.9817 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C03 compound treatment 8.7331845E7 -1.55E7 -0.89 9.3512704E7 -8530000.0 -0.53 -0.9991 -0.9689 2060254 SPBio_000681 CC(=O)CC1CCCCN1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C04 compound treatment 8.8016731E7 -1.48E7 -0.85 8.9293813E7 -1.28E7 -0.79 -1.1553 -0.9993 2060501 SPBio_000682 CC(C)(OC(=O)c1ccccc1)[C@@H]2Cc3cc4ccc(=O)oc4cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C05 compound treatment 9.3110933E7 -9740000.0 -0.56 8.8986259E7 -1.31E7 -0.81 -0.9629 -0.9838 2060245 SPBio_000683 OC[C@H]1O[C@@](CO)(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C06 compound treatment 9.3047074E7 -9800000.0 -0.56 9.0061234E7 -1.2E7 -0.74 -0.9186 -0.9907 3177461 SPBio_000684 CN1C2C[C@H](O)[C@@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C07 compound treatment 7.4765956E7 -2.81E7 -1.61 7.6931659E7 -2.51E7 -1.55 -2.2297 -0.9998 2069293 SPBio_000685 CCc1ccc2c(O)c3C(=O)c4c(O)ccc(O)c4C(=O)c3cc2c1C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C08 compound treatment 9.2242674E7 -1.06E7 -0.61 8.4822315E7 -1.72E7 -1.06 -1.1794 -0.9647 1296906 SPBio_000686 COc1ccc(C(=O)CC(=O)O)c2OC(C)(C)C=Cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C09 compound treatment 2.666262E7 -7.62E7 -4.35 2.8029289E7 -7.4E7 -4.56 -6.3052 -0.9997 1092958 SPBio_000687 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C10 compound treatment 8.3714675E7 -1.91E7 -1.09 7.7416968E7 -2.46E7 -1.52 -1.8469 -0.987 1253 SPBio_000688 C[C@H]1OC=C2C(=C(C(=O)O)C(=O)C(=C2[C@@H]1C)C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C11 compound treatment 9.415126E7 -8700000.0 -0.5 9.101097E7 -1.1E7 -0.68 -0.8326 -0.9881 1262 SPBio_000689 NC[C@H]1CC[C@@H](CC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C12 compound treatment 9.1994957E7 -1.09E7 -0.62 8.6135704E7 -1.59E7 -0.98 -1.1322 -0.9756 1216977 SPBio_000690 CC1(C)Oc2ccc3ccc(=O)oc3c2CC1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C13 compound treatment 9.3706122E7 -9140000.0 -0.52 9.0382352E7 -1.17E7 -0.72 -0.878 -0.9877 1000143 SPBio_000691 NC(Cn1ccc(=O)c(O)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C14 compound treatment 9.1404468E7 -1.14E7 -0.65 8.6821739E7 -1.52E7 -0.94 -1.1262 -0.9844 2321 SPBio_000692 COc1ccc2CC3N(CCc4cc(OC)c(OC)cc34)Cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C15 compound treatment 8.4628013E7 -1.82E7 -1.04 8.1531886E7 -2.05E7 -1.26 -1.6306 -0.9954 3172716 SPBio_000693 NC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C16 compound treatment 8.6745723E7 -1.61E7 -0.92 8.4626358E7 -1.74E7 -1.07 -1.4101 -0.9971 3055383 SPBio_000694 CC(C)(O)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C17 compound treatment 5.5641097E7 -4.72E7 -2.7 6.2896693E7 -3.91E7 -2.41 -3.6143 -0.9985 3078461 SPBio_000695 NCCc1ccccc1S(=O)(=O)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C18 compound treatment 8.6869347E7 -1.6E7 -0.91 8.6998151E7 -1.5E7 -0.93 -1.3018 -1.0 1501 SPBio_000696 NCCc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C19 compound treatment 7.8287442E7 -2.46E7 -1.4 7.6540392E7 -2.55E7 -1.57 -2.1044 -0.9984 3198318 SPBio_000697 C[C@H]1CCCC(=O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C20 compound treatment 9.2099751E7 -1.08E7 -0.61 9.2296699E7 -9750000.0 -0.6 -0.8594 -0.9999 1368 SPBio_000698 CCC(C)C(N)C1=NC(CS1)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NCCCCC2NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(Cc3c[nH]cn3)NC(=O)C(Cc4ccccc4)NC(=O)C(NC(=O)C(CCCN)NC2=O)C(C)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C21 compound treatment 9.1432304E7 -1.14E7 -0.65 9.1269192E7 -1.08E7 -0.66 -0.9312 -1.0 2141061 SPBio_000699 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(C[C@@H](O)[C@@H](O)[C@@H](O)CO)c2cc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C22 compound treatment 9.915107E7 -3700000.0 -0.21 9.5744878E7 -6300000.0 -0.39 -0.4242 -0.9591 2060491 SPBio_000700 CC(C)CC(=O)O[C@@H]1[C@H](OC(=O)C)c2c(OC1(C)C)ccc3ccc(=O)oc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C23 mock treatment 1.04281504E8 1430000.0 0.08 1.05179021E8 3130000.0 0.19 0.1944 0.9269 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 C24 mock treatment 1.20050659E8 1.72E7 0.98 1.1639138E8 1.43E7 0.88 1.3204 0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D01 mock treatment 9.9328132E7 -3520000.0 -0.2 1.02673166E8 627000.0 0.04 -0.115 -0.5611 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D02 mock treatment 8.9633456E7 -1.32E7 -0.76 9.1353396E7 -1.07E7 -0.66 -1.0002 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D03 compound treatment 9.3173312E7 -9680000.0 -0.55 9.1430528E7 -1.06E7 -0.65 -0.8538 -0.9965 2060503 SPBio_000701 C1Oc2ccc(cc2O1)[C@H]3OC[C@@H]4[C@@H](OC[C@H]34)c5ccc6OCOc6c5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D04 compound treatment 8.1324876E7 -2.15E7 -1.23 8.1650339E7 -2.04E7 -1.26 -1.7589 -0.9999 1070 SPBio_000702 CCC(C(CC)c1ccc(O)cc1)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D05 compound treatment 4.0611937E7 -6.22E7 -3.56 4.1830738E7 -6.02E7 -3.71 -5.1399 -0.9998 2060397 SPBio_000703 COc1ccc2C(=O)/C(=C/c3ccc(OC)c(O)c3)/COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D06 compound treatment 3.4313904E7 -6.85E7 -3.92 3.5611437E7 -6.64E7 -4.1 -5.6655 -0.9998 804 SPBio_000704 COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D07 compound treatment 8.5448327E7 -1.74E7 -0.99 8.1810367E7 -2.02E7 -1.25 -1.5853 -0.9937 2069258 SPBio_000705 COc1ccc(c(OC)c1O)c2coc3cc(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D08 compound treatment 5.104313E7 -5.18E7 -2.96 4.6875624E7 -5.52E7 -3.4 -4.4984 -0.9976 1091345 SPBio_000706 Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D09 compound treatment 8.7209923E7 -1.56E7 -0.89 8.2910334E7 -1.91E7 -1.18 -1.4662 -0.9906 1022 SPBio_000707 COc1cc(OC)c2ccc(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D10 compound treatment 6.6357593E7 -3.65E7 -2.09 7.4080551E7 -2.8E7 -1.72 -2.6937 -0.9955 909 SPBio_000708 COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D11 compound treatment 8.6174114E7 -1.67E7 -0.95 8.5997872E7 -1.6E7 -0.99 -1.3735 -0.9998 2060379 SPBio_000709 COc1ccc(cc1)c2coc3c(OC)c(OC)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D12 compound treatment 8.6340304E7 -1.65E7 -0.94 8.2309099E7 -1.97E7 -1.22 -1.5275 -0.9921 599 SPBio_000710 Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D13 compound treatment 8.6833445E7 -1.6E7 -0.92 8.6966536E7 -1.51E7 -0.93 -1.3046 -1.0 3173357 SPBio_000711 CC(=C)[C@@H]1CC[C@@]2(CCC3[C@H](CCC4[C@@]3(C)CCC5C(C)(C)[C@H](O)CC[C@@]54C)C12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D14 compound treatment 2.733614E7 -7.55E7 -4.32 2.9328896E7 -7.27E7 -4.48 -6.2213 -0.9998 3173213 SPBio_000712 COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)C(O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D15 compound treatment 8.7385716E7 -1.55E7 -0.88 8.6754586E7 -1.53E7 -0.94 -1.2915 -0.9995 2069325 SPBio_000713 OC(=O)/C=C/C=C/c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D16 compound treatment 4.4956712E7 -5.79E7 -3.31 4.4526899E7 -5.75E7 -3.55 -4.8468 -0.9994 3078281 SPBio_000714 C[C@H]1OC(C(O)[C@@H]1O)n2cc(F)c(=O)[nH]c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D17 compound treatment 8.7133984E7 -1.57E7 -0.9 8.3464436E7 -1.86E7 -1.15 -1.4451 -0.9928 3173762 SPBio_000715 CC1OC(O[C@@H]/2CC3O[C@@](O)(C[C@H](O)C3C(=O)O)CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C2)C(O)[C@H](N)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D18 compound treatment 5.3994014E7 -4.89E7 -2.79 5.1858076E7 -5.02E7 -3.09 -4.162 -0.9987 1477 SPBio_000716 O=C1O[Pt]OC(=O)C21CCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D19 compound treatment 3.5752197E7 -6.71E7 -3.83 3.5956234E7 -6.61E7 -4.07 -5.5923 -0.9995 1907763 SPBio_000717 Oc1ccc(/C=C/C(=O)OCCc2ccccc2)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D20 compound treatment 9.3935738E7 -8910000.0 -0.51 9.1532823E7 -1.05E7 -0.65 -0.8185 -0.9929 1475 SPBio_000718 Cl[Pt]Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D21 compound treatment 8.5051883E7 -1.78E7 -1.02 8.0688763E7 -2.14E7 -1.32 -1.6502 -0.9919 1913676 SPBio_000719 COc1ccc(cc1)C(=O)/C=C/c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D22 compound treatment 3.7172679E7 -6.57E7 -3.75 3.9247232E7 -6.28E7 -3.87 -5.3915 -0.9999 2080598 SPBio_000720 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC2CC(=O)NC(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D23 mock treatment 9.8551157E7 -4300000.0 -0.25 9.9646931E7 -2400000.0 -0.15 -0.2783 -0.9705 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 D24 mock treatment 1.07284364E8 4430000.0 0.25 1.08408827E8 6360000.0 0.39 0.4565 0.9777 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E01 mock treatment 1.00232146E8 -2620000.0 -0.15 1.00963716E8 -1080000.0 -0.07 -0.153 -0.9338 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E02 mock treatment 9.9466943E7 -3380000.0 -0.19 9.747784E7 -4570000.0 -0.28 -0.3359 -0.9832 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E03 compound treatment 9.6397833E7 -6450000.0 -0.37 9.774031E7 -4310000.0 -0.27 -0.4485 -0.987 2060173 SPBio_000721 CC(C)C1CCC(C)(O)C2CCC(=CC12)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E04 compound treatment 5.5159283E7 -4.77E7 -2.73 5.5639615E7 -4.64E7 -2.86 -3.9501 -0.9997 2060454 SPBio_000722 Oc1cc(O)c2c(=O)cc(oc2c1)c3cc(O)c(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E05 compound treatment 9.0077806E7 -1.28E7 -0.73 9.0325775E7 -1.17E7 -0.72 -1.027 -1.0 3174242 SPBio_000723 OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E06 compound treatment 8.7563786E7 -1.53E7 -0.87 8.9622514E7 -1.24E7 -0.77 -1.1593 -0.9978 1482 SPBio_000724 CN1CCc2cc3OCOc3cc2C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E07 compound treatment 8.5257249E7 -1.76E7 -1.01 8.6205296E7 -1.58E7 -0.98 -1.4015 -0.9999 1000946 SPBio_000725 COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E08 compound treatment 8.6464816E7 -1.64E7 -0.94 8.8695761E7 -1.34E7 -0.82 -1.2441 -0.9979 1398 SPBio_000726 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC(=O)C)c(C)c(C)c2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E09 compound treatment 7.7553846E7 -2.53E7 -1.45 8.15386E7 -2.05E7 -1.26 -1.9162 -0.9978 3078462 SPBio_000727 [Na+].[O-]C(=O)CF 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E10 compound treatment 7.9688582E7 -2.32E7 -1.32 8.1121082E7 -2.09E7 -1.29 -1.8481 -0.9999 1588 SPBio_000728 CC(=O)C1C(=O)C=C2Oc3c(c(O)c(C)c(O)c3C(=O)C)C2(C)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E11 compound treatment 8.441791E7 -1.84E7 -1.05 8.5759519E7 -1.63E7 -1.0 -1.4548 -0.9997 465 SPBio_000729 NCCc1c[nH]cn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E12 compound treatment 8.6285512E7 -1.66E7 -0.95 8.5974664E7 -1.61E7 -0.99 -1.37 -0.9997 2060490 SPBio_000730 C/C=C(\C)/C(=O)O[C@H]1[C@@H](OC(=O)C)C(C)(C)Oc2ccc3ccc(=O)oc3c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E13 compound treatment 8.6603027E7 -1.62E7 -0.93 9.089642E7 -1.11E7 -0.69 -1.1426 -0.989 1000060 SPBio_000731 COC(=O)C1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E14 compound treatment 8.9410261E7 -1.34E7 -0.77 8.6680712E7 -1.54E7 -0.95 -1.2129 -0.9946 1000136 SPBio_000732 CC12CCC3C(=CCc4cc(O)ccc34)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E15 compound treatment 4.5418769E7 -5.74E7 -3.28 4.4761272E7 -5.73E7 -3.53 -4.8179 -0.9993 1243 SPBio_000733 OC[C@H]1OC(C[C@H]1O)n2cc(F)c(=O)[nH]c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E16 compound treatment 8.0560325E7 -2.23E7 -1.27 8.2220862E7 -1.98E7 -1.22 -1.7649 -0.9998 2060357 SPBio_000734 CC(=O)O[C@@H]1CC2C(C)(C)CCC(=O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E17 compound treatment 9.121818E7 -1.16E7 -0.66 9.6384234E7 -5660000.0 -0.35 -0.7169 -0.9548 1498 SPBio_000735 OC(=O)P(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E18 compound treatment 8.6298875E7 -1.66E7 -0.95 8.4552193E7 -1.75E7 -1.08 -1.4314 -0.9979 3078271 SPBio_000736 COC(=O)C[C@H]1C(C)(C)[C@H](O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CC[C@H](C3=C)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E19 compound treatment 6.0658101E7 -4.22E7 -2.41 6.4720295E7 -3.73E7 -2.3 -3.3321 -0.9997 3198319 SPBio_000737 O=C1O[C@]2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E20 compound treatment 9.671357E7 -6140000.0 -0.35 9.3789773E7 -8260000.0 -0.51 -0.6079 -0.9835 2060049 SPBio_000738 Cc1cc(=O)c2c(O)c(C)c(O)cc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E21 compound treatment 9.7806502E7 -5040000.0 -0.29 9.322743E7 -8820000.0 -0.54 -0.5882 -0.956 1290 SPBio_000739 OC(=O)c1ccc(cc1)S(=O)(=O)N(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E22 compound treatment 8.9283699E7 -1.36E7 -0.78 8.1796101E7 -2.03E7 -1.25 -1.4309 -0.9738 2060435 SPBio_000740 COC(=O)C(OC(=O)C)[C@H]1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E23 mock treatment 1.02732802E8 -118000.0 -0.01 9.9594699E7 -2450000.0 -0.15 -0.1116 -0.7379 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 E24 mock treatment 1.10954238E8 8100000.0 0.46 1.07785492E8 5740000.0 0.35 0.5776 0.9912 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F01 mock treatment 1.03735606E8 885000.0 0.05 1.05133561E8 3090000.0 0.19 0.1703 0.865 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F02 mock treatment 9.6250385E7 -6600000.0 -0.38 9.5829393E7 -6220000.0 -0.38 -0.5377 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F03 compound treatment 9.1992908E7 -1.09E7 -0.62 9.0851002E7 -1.12E7 -0.69 -0.9268 -0.9986 2060314 SPBio_000741 COC(=O)c1c(C)c2Oc3c(Cl)c(OC)c(Cl)c(C)c3C(=O)Oc2c(C)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F04 compound treatment 7.7241586E7 -2.56E7 -1.46 7.556822E7 -2.65E7 -1.63 -2.189 -0.9985 1000048 SPBio_000742 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F05 compound treatment 8.4322097E7 -1.85E7 -1.06 8.3853306E7 -1.82E7 -1.12 -1.5418 -0.9996 401 SPBio_000743 COc1cccc2c1cc([N+](=O)[O-])c3c(cc4OCOc4c23)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F06 compound treatment 8.2496173E7 -2.04E7 -1.16 8.1623391E7 -2.04E7 -1.26 -1.7128 -0.9992 1537 SPBio_000744 NC(Cc1ccc(F)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F07 compound treatment 8.4898646E7 -1.8E7 -1.03 8.7437615E7 -1.46E7 -0.9 -1.3622 -0.9979 2060376 SPBio_000745 CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(=O)C)c3C(=O)c12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F08 compound treatment 2.6941842E7 -7.59E7 -4.34 2.8440585E7 -7.36E7 -4.54 -6.276 -0.9997 383 SPBio_000746 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccccc5cc4Cn3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F09 compound treatment 3.3534942E7 -6.93E7 -3.96 3.5118542E7 -6.69E7 -4.13 -5.7184 -0.9998 1334 SPBio_000747 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F10 compound treatment 8.2866713E7 -2.0E7 -1.14 8.0069653E7 -2.2E7 -1.35 -1.7655 -0.9964 767 SPBio_000748 OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(C#N)c3ccccc3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F11 compound treatment 8.2990705E7 -1.99E7 -1.14 8.4909371E7 -1.71E7 -1.06 -1.5495 -0.9994 1314 SPBio_000749 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F12 compound treatment 7.8110615E7 -2.47E7 -1.41 7.9418404E7 -2.26E7 -1.39 -1.9861 -1.0 598 SPBio_000750 Oc1cc2c(=O)oc3c(O)c(O)cc4c(=O)oc(c1O)c2c43 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F13 compound treatment 8.3011198E7 -1.98E7 -1.13 8.4204151E7 -1.78E7 -1.1 -1.5795 -0.9999 2060316 SPBio_000751 COc1c2C=CC(C)(C)Oc2cc3occ(c4ccc5OCOc5c4)c(=O)c13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F14 compound treatment 6.9919229E7 -3.29E7 -1.88 8.234913E7 -1.97E7 -1.21 -2.1894 -0.9775 1539 SPBio_000752 C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)[C@H]23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F15 compound treatment 8.5825105E7 -1.7E7 -0.97 8.9017956E7 -1.3E7 -0.8 -1.2559 -0.9955 960 SPBio_000753 C1N2CN3CN1CN(C2)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F16 compound treatment 8.1713731E7 -2.11E7 -1.21 8.0421439E7 -2.16E7 -1.33 -1.7968 -0.9988 1371 SPBio_000754 CN(C)c1nc(nc(n1)N(C)C)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F17 compound treatment 7.4572219E7 -2.83E7 -1.62 6.9464236E7 -3.26E7 -2.01 -2.563 -0.9942 437 SPBio_000755 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F18 compound treatment 2.6705319E7 -7.61E7 -4.35 2.7865603E7 -7.42E7 -4.57 -6.3106 -0.9997 1135 SPBio_000756 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F19 compound treatment 9.4506917E7 -8340000.0 -0.48 9.7468973E7 -4580000.0 -0.28 -0.5367 -0.9686 1005 SPBio_000757 OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F20 compound treatment 9.5337613E7 -7510000.0 -0.43 9.800064E7 -4050000.0 -0.25 -0.48 -0.9666 726 SPBio_000758 CCOC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F21 compound treatment 9.6459427E7 -6390000.0 -0.37 9.1098282E7 -1.09E7 -0.67 -0.7355 -0.9584 3078274 SPBio_000759 N[C@H](CO)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F22 compound treatment 9.304555E7 -9810000.0 -0.56 8.630432E7 -1.57E7 -0.97 -1.0824 -0.966 946 SPBio_000760 OCCNC(=O)Cn1ccnc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F23 mock treatment 9.6594197E7 -6260000.0 -0.36 9.2582613E7 -9460000.0 -0.58 -0.6653 -0.9724 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 F24 mock treatment 1.01959829E8 -891000.0 -0.05 1.11481189E8 9430000.0 0.58 0.3752 0.6428 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G01 mock treatment 9.5240774E7 -7610000.0 -0.43 9.6746453E7 -5300000.0 -0.33 -0.5385 -0.9901 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G02 mock treatment 9.3838839E7 -9010000.0 -0.52 9.3490043E7 -8560000.0 -0.53 -0.7371 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G03 compound treatment 9.6173582E7 -6680000.0 -0.38 9.1171497E7 -1.09E7 -0.67 -0.7438 -0.9643 1107153 SPBio_000761 CC(=O)c1cc2C=CC(C)(C)Oc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G04 compound treatment 8.9509805E7 -1.33E7 -0.76 8.8040596E7 -1.4E7 -0.86 -1.1496 -0.9981 2069251 SPBio_000762 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C[C@H](O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G05 compound treatment 8.8421875E7 -1.44E7 -0.82 9.0247544E7 -1.18E7 -0.73 -1.0974 -0.998 1984013 SPBio_000763 C/C=C/c1ccc2OCOc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G06 compound treatment 8.4423338E7 -1.84E7 -1.05 8.6775948E7 -1.53E7 -0.94 -1.4103 -0.9984 3078272 SPBio_000764 [Na+].[O-]S(=O)(=O)CCS 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G07 compound treatment 8.7473062E7 -1.54E7 -0.88 8.9667937E7 -1.24E7 -0.76 -1.161 -0.9975 2561 SPBio_000765 Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G08 compound treatment 7.3450592E7 -2.94E7 -1.68 7.6569284E7 -2.55E7 -1.57 -2.2986 -0.9994 1225 SPBio_000766 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G09 compound treatment 7.9651143E7 -2.32E7 -1.33 8.490412E7 -1.71E7 -1.06 -1.6847 -0.9937 2069276 SPBio_000767 COc1cc(cc(OCc2ccccc2)c1OC)c3coc4cc(OCc5ccccc5)c(OC)c(O)c4c3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G10 compound treatment 7.7170327E7 -2.57E7 -1.47 7.9916403E7 -2.21E7 -1.36 -2.0024 -0.9993 2060402 SPBio_000768 COc1ccc2CC[C@H]3CC(=O)CC[C@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G11 compound treatment 8.1518454E7 -2.13E7 -1.22 8.4606628E7 -1.74E7 -1.08 -1.6222 -0.998 1001923 SPBio_000769 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G12 compound treatment 5.2082472E7 -5.08E7 -2.9 3.6260773E7 -6.58E7 -4.06 -4.9191 -0.9865 2069256 SPBio_000770 COc1cc2OCOc2cc1/C=C/C(=O)c3cc(OC)c(OC)cc3OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G13 compound treatment 8.2385956E7 -2.05E7 -1.17 8.5614499E7 -1.64E7 -1.01 -1.5432 -0.9974 1189 SPBio_000771 CO[C@]1(NC(=O)Cc2cccs2)[C@H]3SCC(=C(N3C1=O)C(=O)O)COC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G14 compound treatment 8.6943665E7 -1.59E7 -0.91 9.2226004E7 -9820000.0 -0.61 -1.0709 -0.9805 703 SPBio_000772 OC[C@H]1O[C@@H](Oc2ccccc2CO)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G15 compound treatment 8.9626678E7 -1.32E7 -0.76 9.2445819E7 -9600000.0 -0.59 -0.9529 -0.9927 866 SPBio_000773 Cc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G16 compound treatment 7.245809E7 -3.04E7 -1.74 7.4308833E7 -2.77E7 -1.71 -2.4372 -1.0 976 SPBio_000774 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G17 compound treatment 7.2768192E7 -3.01E7 -1.72 7.2430013E7 -2.96E7 -1.83 -2.5066 -0.9996 1105 SPBio_000775 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G18 compound treatment 8.5154014E7 -1.77E7 -1.01 8.7513452E7 -1.45E7 -0.9 -1.3486 -0.9982 2060370 SPBio_000776 COc1cc2OCOc2cc1c3coc4c5C=CC(C)(C)Oc5c(OC)cc4c3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G19 compound treatment 8.6946844E7 -1.59E7 -0.91 8.9490947E7 -1.26E7 -0.77 -1.19 -0.9968 2097 SPBio_000777 CCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G20 compound treatment 9.3610294E7 -9240000.0 -0.53 9.1774355E7 -1.03E7 -0.63 -0.8212 -0.9959 935 SPBio_000778 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G21 compound treatment 1.00873683E8 -1980000.0 -0.11 1.03978439E8 1930000.0 0.12 0.0043 0.0264 3174101 SPBio_000779 CN1CCc2c(C1)c3ccccc3n2Cc4ccccc4.OS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G22 compound treatment 6.3505514E7 -3.93E7 -2.25 6.5258076E7 -3.68E7 -2.27 -3.1935 -1.0 2060092 SPBio_000780 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CCC3C4CC=C(C(=O)C)[C@@]4(C)C(=O)CC32)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G23 mock treatment 9.1235341E7 -1.16E7 -0.66 9.1319075E7 -1.07E7 -0.66 -0.937 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 G24 mock treatment 1.08439756E8 5590000.0 0.32 1.06380477E8 4330000.0 0.27 0.4148 0.9961 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H01 mock treatment 9.5845635E7 -7000000.0 -0.4 9.8407058E7 -3640000.0 -0.22 -0.4417 -0.9625 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H02 mock treatment 8.9645801E7 -1.32E7 -0.75 8.6583157E7 -1.55E7 -0.95 -1.2076 -0.9933 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H03 compound treatment 8.6756554E7 -1.61E7 -0.92 8.7886538E7 -1.42E7 -0.87 -1.2676 -0.9997 3078275 SPBio_000781 C[C@@H](N)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H04 compound treatment 8.5351942E7 -1.75E7 -1.0 8.4481559E7 -1.76E7 -1.08 -1.4728 -0.9992 695 SPBio_000782 CC1CCC(CC1)NC(=O)N(CCCl)N=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H05 compound treatment 7.2198267E7 -3.07E7 -1.75 7.2111977E7 -2.99E7 -1.85 -2.5435 -0.9997 1000069 SPBio_000783 COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c6OCOc6cc7CCN(C)[C@@H](Cc8ccc(Oc1c2)cc8)c75)cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H06 compound treatment 7.691404E7 -2.59E7 -1.48 7.9863095E7 -2.22E7 -1.37 -2.0151 -0.9992 1394 SPBio_000784 BrCCC(=O)N1CCN(CC1)C(=O)CCBr 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H07 compound treatment 7.4971117E7 -2.79E7 -1.59 7.8963956E7 -2.31E7 -1.42 -2.1328 -0.9984 3078276 SPBio_000785 COC(=O)N/N=C/c1c[n+]([O-])c2ccccc2[n+]1[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H08 compound treatment 7.6235603E7 -2.66E7 -1.52 7.9150357E7 -2.29E7 -1.41 -2.0736 -0.9993 3198421 SPBio_000786 CCC(C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)C12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H09 compound treatment 7.7071192E7 -2.58E7 -1.47 8.0676486E7 -2.14E7 -1.32 -1.9733 -0.9984 3078277 SPBio_000787 CN[C@H]1[C@@H](O)[C@H]2O[C@@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H10 compound treatment 7.8232729E7 -2.46E7 -1.41 8.2550397E7 -1.95E7 -1.2 -1.8446 -0.9969 1211 SPBio_000788 CON 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H11 compound treatment 7.6548991E7 -2.63E7 -1.5 8.0804021E7 -2.12E7 -1.31 -1.9888 -0.9976 1001954 SPBio_000789 C/C=C/1\[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(=C2)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H12 compound treatment 7.6894573E7 -2.6E7 -1.48 7.7767897E7 -2.43E7 -1.5 -2.1072 -1.0 2554 SPBio_000790 C[C@H]1[C@H]2CCC3C4CC=C5C[C@H](CC[C@]5(C)C4CC[C@]23CN1C)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H13 compound treatment 8.4352602E7 -1.85E7 -1.06 8.8218648E7 -1.38E7 -0.85 -1.3503 -0.9943 3198419 SPBio_000791 COc1ccc2cc3c4cc(OC)c(OC)cc4cc[n+]3cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H14 compound treatment 7.0619363E7 -3.22E7 -1.84 7.3849137E7 -2.82E7 -1.74 -2.5316 -0.9996 1307 SPBio_000792 ClC(Cl)C(c1ccc(Cl)cc1)c2ccccc2Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H15 compound treatment 8.4637098E7 -1.82E7 -1.04 8.9127172E7 -1.29E7 -0.8 -1.2992 -0.9913 1017172 SPBio_000793 C=CCSCC=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H16 compound treatment 8.8630504E7 -1.42E7 -0.81 9.2569765E7 -9480000.0 -0.58 -0.9877 -0.9869 2557 SPBio_000794 COS(=O)(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H17 compound treatment 8.8699533E7 -1.42E7 -0.81 9.0649737E7 -1.14E7 -0.7 -1.0686 -0.9975 1117560 SPBio_000795 CC(=C)C1CCC(=CC1)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H18 compound treatment 9.1972955E7 -1.09E7 -0.62 9.3528374E7 -8520000.0 -0.53 -0.8109 -0.9965 3198422 SPBio_000796 CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H]3OC4(O[C@@H]3[C@@H]2O)O[C@H](C(N)CO)[C@H](O)[C@H](O)[C@H]4O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H19 compound treatment 9.5291365E7 -7560000.0 -0.43 9.2725028E7 -9320000.0 -0.57 -0.7118 -0.9901 1047 SPBio_000797 CN(C)CCCN1c2ccccc2Sc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H20 compound treatment 8.9214157E7 -1.36E7 -0.78 8.8467547E7 -1.36E7 -0.84 -1.1429 -0.9994 417 SPBio_000798 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H21 compound treatment 9.0884429E7 -1.2E7 -0.68 8.774389E7 -1.43E7 -0.88 -1.107 -0.9921 681 SPBio_000799 CC(CN1c2ccccc2Sc3ccccc13)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H22 compound treatment 2.7613549E7 -7.52E7 -4.3 2.8417161E7 -7.36E7 -4.54 -6.2498 -0.9996 3046992 SPBio_000800 CO[C@]12[C@@H]3NC3CN2C4=C([C@@H]1COC(=O)N)C(=O)C(=C(C)C4=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H23 mock treatment 9.8076382E7 -4770000.0 -0.27 9.1388045E7 -1.07E7 -0.66 -0.6575 -0.9242 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 H24 mock treatment 1.07709125E8 4860000.0 0.28 1.0317896E8 1130000.0 0.07 0.2457 0.8582 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I01 mock treatment 9.9762056E7 -3090000.0 -0.18 9.9351635E7 -2690000.0 -0.17 -0.2423 -0.9995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I02 mock treatment 9.621453E7 -6640000.0 -0.38 9.6948569E7 -5100000.0 -0.31 -0.4904 -0.9956 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I03 compound treatment 9.2498042E7 -1.04E7 -0.59 9.055767E7 -1.15E7 -0.71 -0.9191 -0.996 647 SPBio_000801 Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I04 compound treatment 9.4417817E7 -8430000.0 -0.48 9.4259678E7 -7790000.0 -0.48 -0.6802 -1.0 2060425 SPBio_000802 COC(=O)[C@@H]1OC(=O)[C@H]2O[C@@]23[C@@]1(C)CCC4[C@@]5(C)CCC(=O)C(C)(C)C5C[C@@H](OC(=O)C)[C@]43C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I05 compound treatment 9.015282E7 -1.27E7 -0.73 9.0606864E7 -1.14E7 -0.71 -1.0118 -0.9999 3174492 SPBio_000803 CN1[C@H]2CC3CC1C(O)C2O3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I06 compound treatment 7.5622068E7 -2.72E7 -1.56 7.9606032E7 -2.24E7 -1.38 -2.0785 -0.9983 1028 SPBio_000804 Oc1ccc(cc1)C(=C2C=CC(=O)C=C2)c3ccc(O)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I07 compound treatment 8.1999895E7 -2.09E7 -1.19 8.4171154E7 -1.79E7 -1.1 -1.6218 -0.9992 1029487 SPBio_000805 OCC(O)Cc1ccc2OCOc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I08 compound treatment 7.7485556E7 -2.54E7 -1.45 8.1801579E7 -2.02E7 -1.25 -1.9075 -0.9972 3198323 SPBio_000806 COc1cc(OC)c2c(=O)c(coc2c1)c3ccc4OCOc4c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I09 compound treatment 6.4756578E7 -3.81E7 -2.18 6.872624E7 -3.33E7 -2.05 -2.9918 -0.9996 3078463 SPBio_000807 CCOC(=O)c1c(C)cc(OC)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I10 compound treatment 7.6662787E7 -2.62E7 -1.5 8.2036954E7 -2.0E7 -1.23 -1.9305 -0.9954 986 SPBio_000808 CN1CC(=O)NC1=N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I11 compound treatment 8.0296474E7 -2.26E7 -1.29 8.4880991E7 -1.72E7 -1.06 -1.6597 -0.9952 2060194 SPBio_000809 COc1cc(O)c(C(=O)O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I12 compound treatment 7.0126248E7 -3.27E7 -1.87 7.398729E7 -2.81E7 -1.73 -2.5455 -0.9992 1013 SPBio_000810 Cc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I13 compound treatment 8.2806125E7 -2.0E7 -1.15 8.6076398E7 -1.6E7 -0.98 -1.5061 -0.9972 1514 SPBio_000811 CC1OC1P(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I14 compound treatment 6.9868016E7 -3.3E7 -1.89 7.3301791E7 -2.87E7 -1.77 -2.5858 -0.9995 1005991 SPBio_000812 O=C1c2ccccc2-c3cccc4cccc1c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I15 compound treatment 3.3729765E7 -6.91E7 -3.95 3.5446626E7 -6.66E7 -4.11 -5.6963 -0.9998 1191 SPBio_000813 Oc1c(Cl)cc(Cl)c2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I16 compound treatment 8.8918796E7 -1.39E7 -0.8 9.4990309E7 -7060000.0 -0.43 -0.8706 -0.9595 2777 SPBio_000814 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I17 compound treatment 8.8353425E7 -1.45E7 -0.83 9.1110814E7 -1.09E7 -0.67 -1.0625 -0.9948 3172720 SPBio_000815 CNC(C)[C@@H]1CC[C@@H](N)[C@@H](OC2[C@@H](N)C[C@@H](N)[C@H](OC3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I18 compound treatment 8.6976627E7 -1.59E7 -0.91 8.8407213E7 -1.36E7 -0.84 -1.236 -0.9993 1294 SPBio_000816 CCN(CC)Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I19 compound treatment 7.7280636E7 -2.56E7 -1.46 6.9503897E7 -3.25E7 -2.01 -2.4518 -0.9879 927 SPBio_000817 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I20 compound treatment 9.7624616E7 -5230000.0 -0.3 9.4482838E7 -7560000.0 -0.47 -0.5409 -0.9768 1092 SPBio_000818 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I21 compound treatment 9.0084793E7 -1.28E7 -0.73 8.7679677E7 -1.44E7 -0.89 -1.1421 -0.9954 1019607 SPBio_000819 CN(C)Cc1c(C)[nH]c2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I22 compound treatment 4.9927175E7 -5.29E7 -3.02 3.9293692E7 -6.28E7 -3.87 -4.874 -0.9926 446 SPBio_000820 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I23 mock treatment 1.01998268E8 -852000.0 -0.05 9.193742E7 -1.01E7 -0.62 -0.4751 -0.7601 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 I24 mock treatment 1.07834639E8 4980000.0 0.28 1.06935258E8 4890000.0 0.3 0.4145 0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J01 mock treatment 1.00012915E8 -2840000.0 -0.16 9.5536593E7 -6510000.0 -0.4 -0.3984 -0.9206 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J02 mock treatment 9.5720594E7 -7130000.0 -0.41 9.3014342E7 -9030000.0 -0.56 -0.6818 -0.9882 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J03 compound treatment 9.2924079E7 -9930000.0 -0.57 9.1326202E7 -1.07E7 -0.66 -0.8684 -0.9971 1175 SPBio_000821 Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J04 compound treatment 9.0244958E7 -1.26E7 -0.72 8.7632956E7 -1.44E7 -0.89 -1.1377 -0.9946 3172714 SPBio_000822 C[n+]1ccccc1/C=N/O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J05 compound treatment 7.6790944E7 -2.61E7 -1.49 7.7883939E7 -2.42E7 -1.49 -2.1063 -1.0 856 SPBio_000823 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J06 compound treatment 8.001544E7 -2.28E7 -1.31 8.2413494E7 -1.96E7 -1.21 -1.7786 -0.9993 1000105 SPBio_000824 CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J07 compound treatment 3.0942256E7 -7.19E7 -4.11 3.3267357E7 -6.88E7 -4.24 -5.9039 -0.9999 1000127 SPBio_000825 CC1(C)O[C@@H]2CC3C4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J08 compound treatment 7.4149E7 -2.87E7 -1.64 7.909944E7 -2.29E7 -1.41 -2.1601 -0.9973 3471036 SPBio_000826 OC(=O)C1=C(C[n+]2ccccc2)CSC3C(NC(=O)Cc4cccs4)C(=O)N31 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J09 compound treatment 7.3288959E7 -2.96E7 -1.69 7.8168536E7 -2.39E7 -1.47 -2.2354 -0.9976 1053 SPBio_000827 COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J10 compound treatment 6.1270436E7 -4.16E7 -2.38 6.7859446E7 -3.42E7 -2.11 -3.1705 -0.9982 1338 SPBio_000828 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J11 compound treatment 7.5520625E7 -2.73E7 -1.56 7.9773817E7 -2.23E7 -1.37 -2.0753 -0.9979 938 SPBio_000829 Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J12 compound treatment 7.7091508E7 -2.58E7 -1.47 8.0894804E7 -2.12E7 -1.3 -1.9629 -0.9982 1107 SPBio_000830 OC(=O)CN1CCNC1=N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J13 compound treatment 7.9121984E7 -2.37E7 -1.36 8.272468E7 -1.93E7 -1.19 -1.8011 -0.9979 1146 SPBio_000831 Nc1ccc(cc1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J14 compound treatment 7.9495112E7 -2.34E7 -1.33 8.4769287E7 -1.73E7 -1.06 -1.6969 -0.9937 1271 SPBio_000832 CC(=O)OC(CC(=O)O)[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J15 compound treatment 8.2888815E7 -2.0E7 -1.14 8.5991575E7 -1.61E7 -0.99 -1.5065 -0.9975 721 SPBio_000833 CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J16 compound treatment 7.96393E7 -2.32E7 -1.33 8.1722419E7 -2.03E7 -1.25 -1.8239 -0.9996 1142 SPBio_000834 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J17 compound treatment 8.5196708E7 -1.77E7 -1.01 8.9630023E7 -1.24E7 -0.77 -1.2546 -0.9907 2060131 SPBio_000835 CCOC(=O)c1oc2c(OC)c(O)cc(O)c2c(=O)c1c3cc(OC)c(OC)c(OC)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J18 compound treatment 8.3315176E7 -1.95E7 -1.12 8.7725717E7 -1.43E7 -0.88 -1.4137 -0.9932 725 SPBio_000836 CC(=C)[C@@H]1CCC(=CC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J19 compound treatment 8.660644E7 -1.62E7 -0.93 8.7732823E7 -1.43E7 -0.88 -1.2804 -0.9997 3044782 SPBio_000837 NC(=N)N.OC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J20 compound treatment 9.2054891E7 -1.08E7 -0.62 9.4570377E7 -7480000.0 -0.46 -0.7621 -0.9897 1372 SPBio_000838 OC(=O)c1cccnc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J21 compound treatment 9.352299E7 -9330000.0 -0.53 9.0169197E7 -1.19E7 -0.73 -0.8946 -0.9879 1429 SPBio_000839 CCCCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J22 compound treatment 8.677922E7 -1.61E7 -0.92 8.4647593E7 -1.74E7 -1.07 -1.4079 -0.997 937 SPBio_000840 CCC(=O)c1ccc2Sc3ccccc3N(CC(C)N(C)C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J23 mock treatment 1.04974543E8 2120000.0 0.12 1.05847691E8 3800000.0 0.23 0.2515 0.9531 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 J24 mock treatment 1.08133793E8 5280000.0 0.3 1.03919149E8 1870000.0 0.12 0.2951 0.913 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K01 mock treatment 9.723875E7 -5610000.0 -0.32 9.9531164E7 -2520000.0 -0.16 -0.3364 -0.9444 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K02 mock treatment 8.854253E7 -1.43E7 -0.82 9.4958741E7 -7090000.0 -0.44 -0.8872 -0.9569 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K03 compound treatment 9.3908565E7 -8940000.0 -0.51 9.4726144E7 -7320000.0 -0.45 -0.6804 -0.9981 3054976 SPBio_000841 CC(C)[C@@H]1CC[C@@H](C)CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K04 compound treatment 8.8596817E7 -1.43E7 -0.81 8.8894151E7 -1.32E7 -0.81 -1.1493 -1.0 3173242 SPBio_000842 Nc1nc2cc(Cl)ccc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K05 compound treatment 8.3383575E7 -1.95E7 -1.11 8.6475835E7 -1.56E7 -0.96 -1.4654 -0.9973 2060306 SPBio_000843 C[C@@H](CCOC(=O)C)CCC=C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K06 compound treatment 7.2185957E7 -3.07E7 -1.75 7.8399094E7 -2.36E7 -1.46 -2.27 -0.9958 2060291 SPBio_000844 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K07 compound treatment 8.203581E7 -2.08E7 -1.19 8.6799647E7 -1.52E7 -0.94 -1.5057 -0.9932 3235 SPBio_000845 OC(=O)c1ccccc1OC(=O)c2ccccc2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K08 compound treatment 7.7574075E7 -2.53E7 -1.44 8.3956317E7 -1.81E7 -1.12 -1.81 -0.9918 1156 SPBio_000846 OC(=O)c1cc(O)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K09 compound treatment 2.8811714E7 -7.4E7 -4.23 2.9684897E7 -7.24E7 -4.46 -6.1462 -0.9997 3177523 SPBio_000847 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O)[C@H](C)O2)N(C)C)c3c(O)c4C(=O)c5c(O)ccc(O)c5C(=O)c4cc3[C@H]1C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K10 compound treatment 7.066011E7 -3.22E7 -1.84 7.670286E7 -2.53E7 -1.56 -2.4056 -0.9967 1308020 SPBio_000848 COc1ccc(cc1)c2cc(=O)c3ccccc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K11 compound treatment 3.3177771E7 -6.97E7 -3.98 3.4712376E7 -6.73E7 -4.15 -5.7506 -0.9998 1056 SPBio_000849 Nc1nc2nc[nH]c2c(=S)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K12 compound treatment 7.7841185E7 -2.5E7 -1.43 8.2997685E7 -1.9E7 -1.17 -1.841 -0.9952 1599 SPBio_000850 C=CCc1ccc2OCOc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K13 compound treatment 7.9888543E7 -2.3E7 -1.31 8.343975E7 -1.86E7 -1.15 -1.739 -0.9977 999 SPBio_000851 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K14 compound treatment 8.1927168E7 -2.09E7 -1.2 8.6317465E7 -1.57E7 -0.97 -1.5311 -0.9946 3058468 SPBio_000852 COc1ccc(OC)c(c1)C(O)C(C)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K15 compound treatment 2.7394342E7 -7.55E7 -4.31 2.8090949E7 -7.4E7 -4.56 -6.2729 -0.9996 1356 SPBio_000853 Oc1cccc2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K16 compound treatment 8.3081056E7 -1.98E7 -1.13 9.0291286E7 -1.18E7 -0.72 -1.3113 -0.9769 2553 SPBio_000854 CNNC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K17 compound treatment 5.8229767E7 -4.46E7 -2.55 6.7249371E7 -3.48E7 -2.14 -3.32 -0.9963 3198320 SPBio_000855 Clc1ccc(CO/N=C(\Cn2ccnc2)/c3ccc(Cl)cc3Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K18 compound treatment 8.430616E7 -1.85E7 -1.06 8.9566658E7 -1.25E7 -0.77 -1.2934 -0.9876 422 SPBio_000856 Oc1cccc2C(=O)C=CC(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K19 compound treatment 9.0874264E7 -1.2E7 -0.68 9.5204035E7 -6840000.0 -0.42 -0.7822 -0.9729 3047 SPBio_000857 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(=C3[C@H]2OC1=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K20 compound treatment 9.3802429E7 -9050000.0 -0.52 9.3667142E7 -8380000.0 -0.52 -0.7309 -1.0 3198324 SPBio_000858 C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(O)cc(O)c4c3=O)c5ccc(O)c(O)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K21 compound treatment 2.8418746E7 -7.44E7 -4.25 2.9129696E7 -7.29E7 -4.49 -6.1862 -0.9996 1003215 SPBio_000859 CC(C)C1=CC(=O)C(=CC1=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K22 compound treatment 3.384443E7 -6.9E7 -3.94 3.6664621E7 -6.54E7 -4.03 -5.6385 -0.9999 1330 SPBio_000860 ClCCN(CCCl)CCCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K23 mock treatment 8.999692E7 -1.29E7 -0.73 9.3135256E7 -8910000.0 -0.55 -0.9079 -0.9897 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 K24 mock treatment 1.05831563E8 2980000.0 0.17 1.06102036E8 4060000.0 0.25 0.2972 0.9825 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L01 mock treatment 9.4274068E7 -8580000.0 -0.49 9.0194271E7 -1.19E7 -0.73 -0.8632 -0.9812 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L02 mock treatment 8.8473125E7 -1.44E7 -0.82 8.6619735E7 -1.54E7 -0.95 -1.2534 -0.9974 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L03 compound treatment 9.2941022E7 -9910000.0 -0.57 9.2507915E7 -9540000.0 -0.59 -0.8162 -0.9998 930 SPBio_000861 CC(CN1CCCCC1)C(=O)c2ccc(C)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L04 compound treatment 8.3918892E7 -1.89E7 -1.08 8.6682701E7 -1.54E7 -0.95 -1.4347 -0.9978 1325 SPBio_000862 NC1(CCCC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L05 compound treatment 4.8417138E7 -5.44E7 -3.11 4.7099818E7 -5.49E7 -3.39 -4.5948 -0.9991 2576 SPBio_000863 S=C=NCc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L06 compound treatment 7.9851043E7 -2.3E7 -1.31 8.7739949E7 -1.43E7 -0.88 -1.553 -0.9812 3173241 SPBio_000864 C[C@@]12CCC3C(CC[C@H]4C[C@@H](CC[C@@]43C)OS(=O)(=O)O)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L07 compound treatment 7.8613754E7 -2.42E7 -1.39 8.4067951E7 -1.8E7 -1.11 -1.7631 -0.9939 1099 SPBio_000865 CC(=O)NCCCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L08 compound treatment 7.5445585E7 -2.74E7 -1.57 8.2475254E7 -1.96E7 -1.21 -1.9606 -0.9917 1266 SPBio_000866 CCn1cc(C(=O)O)c(=O)c2cc3OCOc3cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L09 compound treatment 7.8285808E7 -2.46E7 -1.4 8.2210654E7 -1.98E7 -1.22 -1.8573 -0.9976 850 SPBio_000867 Clc1cccc(c1)N2CCN(CCCn3nc4ccccn4c3=O)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L10 compound treatment 7.3730043E7 -2.91E7 -1.66 8.0775229E7 -2.13E7 -1.31 -2.104 -0.993 1081 SPBio_000868 Cc1c(N)c(=O)n(c2ccccc2)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L11 compound treatment 7.1896791E7 -3.1E7 -1.77 7.6299518E7 -2.57E7 -1.59 -2.3732 -0.9985 1413 SPBio_000869 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L12 compound treatment 7.511921E7 -2.77E7 -1.58 8.1377013E7 -2.07E7 -1.27 -2.0216 -0.9941 1000116 SPBio_000870 CC(=O)CC(c1ccccc1)c2c(O)c3ccccc3oc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L13 compound treatment 7.9813462E7 -2.3E7 -1.32 8.3029147E7 -1.9E7 -1.17 -1.7599 -0.9983 1433 SPBio_000871 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L14 compound treatment 7.7142092E7 -2.57E7 -1.47 8.3271494E7 -1.88E7 -1.16 -1.8573 -0.993 1075 SPBio_000872 CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L15 compound treatment 7.3021728E7 -2.98E7 -1.7 7.2781417E7 -2.93E7 -1.8 -2.481 -0.9996 801 SPBio_000873 CN(C)CC/C=C/1\c2ccccc2Sc3ccc(Cl)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L16 compound treatment 8.4368233E7 -1.85E7 -1.06 8.5922249E7 -1.61E7 -0.99 -1.4497 -0.9995 1201 SPBio_000874 COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L17 compound treatment 8.9311004E7 -1.35E7 -0.77 9.2880268E7 -9170000.0 -0.57 -0.9467 -0.9881 1278 SPBio_000875 COc1ccc(cc1O)c2cc(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@H](C)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L18 compound treatment 6.1878059E7 -4.1E7 -2.34 6.6174509E7 -3.59E7 -2.21 -3.2194 -0.9996 1061 SPBio_000876 Nc1nc(N)c2nc(c(N)nc2n1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L19 compound treatment 9.2190935E7 -1.07E7 -0.61 9.5484262E7 -6560000.0 -0.4 -0.7168 -0.9802 3177517 SPBio_000877 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)C(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L20 compound treatment 9.7387457E7 -5460000.0 -0.31 9.7131217E7 -4920000.0 -0.3 -0.435 -0.9999 1341 SPBio_000878 CC(=O)OCC(COC(=O)C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L21 compound treatment 9.8960219E7 -3890000.0 -0.22 9.322616E7 -8820000.0 -0.54 -0.5417 -0.9221 1162 SPBio_000879 Cc1c(NC(=O)c2cccnc2)c(=O)n(c3ccccc3)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L22 compound treatment 2.7028246E7 -7.58E7 -4.33 2.8112543E7 -7.39E7 -4.56 -6.2868 -0.9997 3173364 SPBio_000880 C[C@H]1[C@@]2(C)CCC3C(CCC4C[C@H](CC[C@@]43C)O[C@H]5O[C@H](CO)[C@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@H]7OC[C@@H](O)[C@H](O)[C@H]7O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]6O)[C@H](O)[C@H]5O)C2O[C@]91CC[C@H](C)CN9 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L23 mock treatment 9.494232E7 -7910000.0 -0.45 9.0117127E7 -1.19E7 -0.74 -0.8396 -0.9727 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 L24 mock treatment 1.11364397E8 8510000.0 0.49 1.06510766E8 4460000.0 0.28 0.5387 0.9636 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M01 mock treatment 1.12781837E8 9930000.0 0.57 1.08087565E8 6040000.0 0.37 0.6647 0.9791 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M02 mock treatment 9.9478861E7 -3370000.0 -0.19 9.7916828E7 -4130000.0 -0.25 -0.3163 -0.9906 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M03 compound treatment 9.5338777E7 -7510000.0 -0.43 9.4477666E7 -7570000.0 -0.47 -0.6335 -0.9991 3174245 SPBio_000881 OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M04 compound treatment 2.6637133E7 -7.62E7 -4.36 2.8045032E7 -7.4E7 -4.56 -6.3055 -0.9997 1019365 SPBio_000882 COC1=CC(=O)C=C(OC)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M05 compound treatment 2.7198962E7 -7.57E7 -4.32 2.8223335E7 -7.38E7 -4.55 -6.275 -0.9997 2060246 SPBio_000883 C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C/C=C/3\[C@H](O)COC3=O)C(=C)CCC12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M06 compound treatment 8.1631997E7 -2.12E7 -1.21 8.9593157E7 -1.25E7 -0.77 -1.4003 -0.9757 2081029 SPBio_000884 CN/C(=N\C#N)/NCCSCc1nc[nH]c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M07 compound treatment 4.1748784E7 -6.11E7 -3.49 4.6843332E7 -5.52E7 -3.4 -4.8754 -0.9999 907310 SPBio_000885 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M08 compound treatment 7.8820166E7 -2.4E7 -1.37 8.5373031E7 -1.67E7 -1.03 -1.6979 -0.9898 2060352 SPBio_000886 O=C(O[C@H]1Cc2c(OC(=O)c3ccccc3)cc(OC(=O)c4ccccc4)cc2O[C@@H]1c5ccc(OC(=O)c6ccccc6)c(OC(=O)c7ccccc7)c5)c8ccccc8 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M09 compound treatment 6.8368411E7 -3.45E7 -1.97 7.8088528E7 -2.4E7 -1.48 -2.4378 -0.9899 3057880 SPBio_000887 COc1ccc(cc1)C(=C(c2ccc(OC)cc2)c3ccc(OC)cc3)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M10 compound treatment 7.2238204E7 -3.06E7 -1.75 7.7697756E7 -2.43E7 -1.5 -2.2984 -0.9971 847 SPBio_000888 CC(=CCC/C(=C/CO)/C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M11 compound treatment 8.1862111E7 -2.1E7 -1.2 8.6726335E7 -1.53E7 -0.94 -1.516 -0.993 3060195 SPBio_000889 COC(C)(C)CCC[C@H](C)C/C=C/C(=C/C(=O)OC(C)C)/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M12 compound treatment 7.7300581E7 -2.56E7 -1.46 8.4908184E7 -1.71E7 -1.06 -1.7795 -0.9874 1029 SPBio_000890 CC(C(=O)O)c1ccc(cc1)N2Cc3ccccc3C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M13 compound treatment 7.621454E7 -2.66E7 -1.52 8.204026E7 -2.0E7 -1.23 -1.9484 -0.9945 3173342 SPBio_000891 CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)COC(=O)N)\c3ccco3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M14 compound treatment 5.9554655E7 -4.33E7 -2.47 6.2721959E7 -3.93E7 -2.42 -3.4638 -0.9999 784 SPBio_000892 Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M15 compound treatment 7.9802274E7 -2.3E7 -1.32 8.4389404E7 -1.77E7 -1.09 -1.7011 -0.9955 370 SPBio_000893 O=C1N(C2CCC(=O)NC2=O)C(=O)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M16 compound treatment 2.9328291E7 -7.35E7 -4.2 2.9876121E7 -7.22E7 -4.45 -6.1169 -0.9996 1195 SPBio_000894 C[C@@]12CCC3C(CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]2(O)CCC1C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M17 compound treatment 6.2264177E7 -4.06E7 -2.32 6.3941972E7 -3.81E7 -2.35 -3.3011 -1.0 3198321 SPBio_000895 CCCCCCCC/C=C/CCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M18 compound treatment 9.030798E7 -1.25E7 -0.72 9.1232314E7 -1.08E7 -0.67 -0.9782 -0.9993 1256 SPBio_000896 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M19 compound treatment 7.9705421E7 -2.31E7 -1.32 8.4334472E7 -1.77E7 -1.09 -1.7074 -0.9955 1713087 SPBio_000897 COc1ccc(cc1OC)c2cc(=O)c3ccccc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M20 compound treatment 9.1865292E7 -1.1E7 -0.63 9.502867E7 -7020000.0 -0.43 -0.7498 -0.9835 41 SPBio_000898 OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M21 compound treatment 9.7366668E7 -5480000.0 -0.31 9.9997146E7 -2050000.0 -0.13 -0.3109 -0.9202 3058622 SPBio_000899 OC1=CC2=C3c4ccc(O)cc4OC[C@]3(O)CC2=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M22 compound treatment 9.1688401E7 -1.12E7 -0.64 9.2374128E7 -9670000.0 -0.6 -0.8727 -0.9994 2060048 SPBio_000900 CC(=O)c1c(O)c(C)c(O)c2c1oc3c(C(=O)C)c(O)c(C)c(O)c32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M23 mock treatment 9.8395986E7 -4450000.0 -0.25 9.5400069E7 -6650000.0 -0.41 -0.4697 -0.9738 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 M24 mock treatment 1.14123795E8 1.13E7 0.64 1.07321615E8 5280000.0 0.33 0.6855 0.9499 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N01 mock treatment 1.09547837E8 6700000.0 0.38 1.05637116E8 3590000.0 0.22 0.4272 0.9661 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N02 mock treatment 9.8984102E7 -3870000.0 -0.22 1.02976329E8 930000.0 0.06 -0.1157 -0.5069 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N03 compound treatment 8.4515772E7 -1.83E7 -1.05 9.1921249E7 -1.01E7 -0.62 -1.1823 -0.9694 860 SPBio_000901 CN(C)C(=O)Oc1ccc[n+](C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N04 compound treatment 9.0435332E7 -1.24E7 -0.71 8.9908956E7 -1.21E7 -0.75 -1.0308 -0.9996 2407 SPBio_000902 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N05 compound treatment 8.3620328E7 -1.92E7 -1.1 8.4699328E7 -1.73E7 -1.07 -1.5333 -0.9999 1268 SPBio_000903 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3cc(C)on3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N06 compound treatment 9.8781021E7 -4070000.0 -0.23 1.05339576E8 3290000.0 0.2 -0.0209 -0.0677 811 SPBio_000904 CC(=O)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N07 compound treatment 7.2758181E7 -3.01E7 -1.72 8.1197811E7 -2.08E7 -1.29 -2.1248 -0.9897 1100 SPBio_000905 CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N08 compound treatment 2.6569373E7 -7.63E7 -4.36 2.7479623E7 -7.46E7 -4.6 -6.3329 -0.9997 928 SPBio_000906 CC(=O)O[Hg]c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N09 compound treatment 4.581482E7 -5.7E7 -3.26 5.1795945E7 -5.03E7 -3.1 -4.4953 -0.9997 3173346 SPBio_000907 CC[C@H](C1OC(CC)(C[C@@H]1C)C2CC[C@](O)(CC)[C@H](C)O2)C(=O)C(C)[C@@H](O)[C@H](C)CCc3ccc(C)c(O)c3C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N10 compound treatment 5.4276706E7 -4.86E7 -2.78 5.6876831E7 -4.52E7 -2.78 -3.9318 -1.0 1374 SPBio_000908 Oc1c(Br)cc(Br)c2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N11 compound treatment 6.9349229E7 -3.35E7 -1.91 8.0866277E7 -2.12E7 -1.31 -2.2771 -0.9826 1274 SPBio_000909 C1CN2C[C@@H](N=C2S1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N12 compound treatment 7.314981E7 -2.97E7 -1.7 8.2138572E7 -1.99E7 -1.23 -2.068 -0.9873 816 SPBio_000910 Cc1cc(cc(C)c1CC2=NCCN2)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N13 compound treatment 7.2400302E7 -3.05E7 -1.74 7.8748534E7 -2.33E7 -1.44 -2.2461 -0.9954 1232 SPBio_000911 OC1=C(O)C(=O)C(=C(O)C1=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N14 compound treatment 7.5225564E7 -2.76E7 -1.58 8.0756114E7 -2.13E7 -1.31 -2.0444 -0.9958 471 SPBio_000912 CCCC(CCC)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N15 compound treatment 2.7928524E7 -7.49E7 -4.28 2.8553728E7 -7.35E7 -4.53 -6.2312 -0.9996 1051 SPBio_000913 CC(=O)Oc1ccc(Cl)c2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N16 compound treatment 7.7235721E7 -2.56E7 -1.46 8.5586612E7 -1.65E7 -1.01 -1.7526 -0.984 1044 SPBio_000914 C[C@H](CCC(=O)O)[C@H]1CCC2C3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N17 compound treatment 8.911444E7 -1.37E7 -0.79 9.0506833E7 -1.15E7 -0.71 -1.0581 -0.9988 975 SPBio_000915 CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N18 compound treatment 8.0933809E7 -2.19E7 -1.25 8.7212588E7 -1.48E7 -0.91 -1.5323 -0.988 1000 SPBio_000916 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N19 compound treatment 8.684789E7 -1.6E7 -0.91 9.1492973E7 -1.06E7 -0.65 -1.1067 -0.9861 798 SPBio_000917 CCCCCCOc1ccccc1C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N20 compound treatment 3.9909362E7 -6.29E7 -3.6 4.162133E7 -6.04E7 -3.72 -5.1774 -0.9998 977 SPBio_000918 C[C@@]12C[C@H](O)[C@@]3(F)C(CCC4=CC(=O)C=C[C@@]43C)C2C[C@@H](O)[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N21 compound treatment 9.4053871E7 -8800000.0 -0.5 9.3495411E7 -8550000.0 -0.53 -0.7282 -0.9997 1000115 SPBio_000919 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N22 compound treatment 1.00642556E8 -2210000.0 -0.13 9.427219E7 -7770000.0 -0.48 -0.4281 -0.8639 971 SPBio_000920 CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N23 mock treatment 9.8394559E7 -4460000.0 -0.25 9.469048E7 -7360000.0 -0.45 -0.5007 -0.9628 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 N24 mock treatment 1.11878916E8 9030000.0 0.52 1.08495877E8 6450000.0 0.4 0.646 0.9917 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O01 mock treatment 1.07493642E8 4640000.0 0.27 1.08842865E8 6800000.0 0.42 0.4839 0.9757 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O02 mock treatment 9.2282141E7 -1.06E7 -0.6 9.2752973E7 -9290000.0 -0.57 -0.8322 -0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O03 compound treatment 5.3158109E7 -4.97E7 -2.84 5.7031979E7 -4.5E7 -2.77 -3.9703 -0.9999 1053058 SPBio_000921 COc1cc(OC)c2c(=O)c(O)c(oc2c1)c3ccc(OC)c(OC)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O04 compound treatment 8.7939658E7 -1.49E7 -0.85 9.1929675E7 -1.01E7 -0.62 -1.0435 -0.9882 1003514 SPBio_000922 COc1cc(cc(OC)c1OC)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O05 compound treatment 2.6270061E7 -7.66E7 -4.38 2.7531177E7 -7.45E7 -4.59 -6.3427 -0.9997 3055171 SPBio_000923 COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CCc5c(C)c(O)c(O)cc5[C@]4(C)CC[C@@]3(C)C2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O06 compound treatment 8.1095469E7 -2.18E7 -1.24 8.4611457E7 -1.74E7 -1.07 -1.6391 -0.9974 2060483 SPBio_000924 CC(=O)N[C@@H](CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O07 compound treatment 7.1514336E7 -3.13E7 -1.79 7.0598924E7 -3.14E7 -1.94 -2.6371 -0.9992 2069289 SPBio_000925 CC(=O)Oc1cc2c(CC3OC34[C@@]2(C)CC[C@@]5(C)C6C[C@@](C)(CC[C@]6(C)CC[C@]45C)C(=O)O)c(C)c1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O08 compound treatment 7.4812804E7 -2.8E7 -1.6 8.4876229E7 -1.72E7 -1.06 -1.8815 -0.9797 3078273 SPBio_000926 COc1cc(C)c(C(=O)Oc2cc(C)c(O)c(C(=O)O)c2C)c(O)c1C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O09 compound treatment 5.7223211E7 -4.56E7 -2.61 6.7017066E7 -3.5E7 -2.16 -3.3708 -0.9956 3198322 SPBio_000927 CC1CNC(=O)CCC2(C)C(CC(=O)N)C3N4C2=C(C)C5=N6C(=CC7=N8C(=C(C)C9=N(C3(C)C(C)(CC(=O)N)C9CCC(=O)N)[Co+]486(C[C@H]%10OC([C@H](O)[C@@H]%10O)n%11cnc%12c(N)ncnc%11%12)N%13=CN(C%14O[C@H](CO)[C@@H](OP(=O)(O)O1)[C@H]%14O)c%15cc(C)c(C)cc%13%15)C(C)(CC(=O)N)C7CCC(=O)N)C(C)(C)C5CCC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O10 compound treatment 6.5001017E7 -3.78E7 -2.16 7.4640204E7 -2.74E7 -1.69 -2.7242 -0.9925 112 SPBio_000928 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O11 compound treatment 6.7581147E7 -3.53E7 -2.02 7.6313535E7 -2.57E7 -1.59 -2.547 -0.993 1538 SPBio_000929 Oc1ccc(c(O)c1)c2oc3cc(O)cc(O)c3c(=O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O12 compound treatment 7.1742767E7 -3.11E7 -1.78 8.0343896E7 -2.17E7 -1.34 -2.2031 -0.9902 3198325 SPBio_000930 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O13 compound treatment 7.4704498E7 -2.81E7 -1.61 8.2582535E7 -1.95E7 -1.2 -1.9858 -0.9896 1343 SPBio_000931 COC1=CC(C)[C@@H]2C[C@H]3OC(=O)C[C@H]4C(=C(OC)C(=O)C([C@@]34C)[C@@]2(C)C1=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O14 compound treatment 5.0753454E7 -5.21E7 -2.98 5.2636508E7 -4.94E7 -3.05 -4.259 -0.9999 2080198 SPBio_000932 CC(=O)C1=C(O)C2C3C(Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O15 compound treatment 7.0670259E7 -3.22E7 -1.84 8.0659474E7 -2.14E7 -1.32 -2.2327 -0.9867 2069234 SPBio_000933 CN1CCc2cc3OCOc3cc2[C@H]1C4OC(=O)c5c6OCOc6ccc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O16 compound treatment 8.5111069E7 -1.77E7 -1.01 8.9149608E7 -1.29E7 -0.79 -1.279 -0.9928 1353 SPBio_000934 COC(=O)/C(=C/1\OC(=O)C(C1=O)c2ccccc2)/c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O17 compound treatment 7.8511062E7 -2.43E7 -1.39 8.99751E7 -1.21E7 -0.74 -1.5098 -0.957 3078269 SPBio_000935 OCC(O)CC(O)CCCCCCCCCCCC=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O18 compound treatment 8.1096484E7 -2.18E7 -1.24 8.2951348E7 -1.91E7 -1.18 -1.7114 -0.9996 2060168 SPBio_000936 C/C(=C/CC1[C@](C)(O)CC[C@H]2C(C)(C)CCC[C@]12C)/C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O19 compound treatment 9.1331808E7 -1.15E7 -0.66 9.593794E7 -6110000.0 -0.38 -0.7318 -0.9649 1000122 SPBio_000937 O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O20 compound treatment 5.1338152E7 -5.15E7 -2.94 4.157061E7 -6.05E7 -3.73 -4.7177 -0.9932 1576 SPBio_000938 CC(=CCc1c(O)c2c(=O)c(coc2c3C=CC(C)(C)Oc13)c4ccc(O)c(O)c4)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O21 compound treatment 9.7393674E7 -5460000.0 -0.31 9.872787E7 -3320000.0 -0.2 -0.3652 -0.9791 1601 SPBio_000939 COc1c(OC)c2ccc(=O)oc2c3ccoc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O22 compound treatment 9.6266271E7 -6580000.0 -0.38 9.4099496E7 -7950000.0 -0.49 -0.6125 -0.9915 994 SPBio_000940 N[C@@H](CCONC(=N)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O23 mock treatment 9.8569355E7 -4280000.0 -0.24 9.4737616E7 -7310000.0 -0.45 -0.4916 -0.9589 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 O24 mock treatment 1.12770368E8 9920000.0 0.57 1.11811027E8 9760000.0 0.6 0.8265 0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P01 mock treatment 1.08004367E8 5150000.0 0.29 1.09081093E8 7030000.0 0.43 0.5149 0.9822 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P02 mock treatment 9.9958589E7 -2890000.0 -0.17 9.9750726E7 -2300000.0 -0.14 -0.2169 -0.997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P03 compound treatment 8.6623248E7 -1.62E7 -0.93 8.5766099E7 -1.63E7 -1.0 -1.3654 -0.9992 1000112 SPBio_000941 CC(=O)O[C@H]1[C@@H](O)C2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P04 compound treatment 8.8194546E7 -1.47E7 -0.84 8.8400491E7 -1.36E7 -0.84 -1.1871 -1.0 1000129 SPBio_000942 CC1(C)[C@H](CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P05 compound treatment 5.3756993E7 -4.91E7 -2.81 5.5310813E7 -4.67E7 -2.88 -4.0211 -0.9999 1000045 SPBio_000943 CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)C4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P06 compound treatment 3.7114476E7 -6.57E7 -3.76 3.8197818E7 -6.38E7 -3.94 -5.4396 -0.9997 1004 SPBio_000944 Oc1ccc2c(=O)cc(oc2c1O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P07 compound treatment 8.2070668E7 -2.08E7 -1.19 8.5549386E7 -1.65E7 -1.02 -1.5588 -0.997 1450 SPBio_000945 NCCc1c[nH]c2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P08 compound treatment 7.7210104E7 -2.56E7 -1.47 8.4503658E7 -1.75E7 -1.08 -1.8008 -0.9888 922 SPBio_000946 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P09 compound treatment 7.3185933E7 -2.97E7 -1.7 7.504574E7 -2.7E7 -1.66 -2.3757 -1.0 1586 SPBio_000947 NCCCCNCCCN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P10 compound treatment 7.1718341E7 -3.11E7 -1.78 8.1398819E7 -2.06E7 -1.27 -2.1581 -0.9865 1106 SPBio_000948 CCC(=O)c1c(O)cc(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P11 compound treatment 7.6555855E7 -2.63E7 -1.5 7.5080944E7 -2.7E7 -1.66 -2.238 -0.9987 831758 SPBio_000949 Oc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P12 compound treatment 7.2991428E7 -2.99E7 -1.71 7.9182931E7 -2.29E7 -1.41 -2.2032 -0.9955 1533 SPBio_000950 Cc1cc(CC(=O)O)n(C)c1C(=O)c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P13 compound treatment 7.8109598E7 -2.47E7 -1.41 8.2344153E7 -1.97E7 -1.21 -1.8586 -0.9971 1898 SPBio_000951 OC(=O)CC[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P14 compound treatment 7.9766932E7 -2.31E7 -1.32 7.8433425E7 -2.36E7 -1.46 -1.9621 -0.9988 1209 SPBio_000952 CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P15 compound treatment 8.0460382E7 -2.24E7 -1.28 7.8661878E7 -2.34E7 -1.44 -1.9241 -0.9982 1089854 SPBio_000953 Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P16 compound treatment 8.3542659E7 -1.93E7 -1.1 7.9445654E7 -2.26E7 -1.39 -1.7654 -0.9933 1152 SPBio_000954 CN(C)CCN(Cc1ccccc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P17 compound treatment 4.0296704E7 -6.26E7 -3.58 4.2223065E7 -5.98E7 -3.69 -5.1355 -0.9999 1001531 SPBio_000955 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P18 compound treatment 4.6061876E7 -5.68E7 -3.25 4.5412539E7 -5.66E7 -3.49 -4.7635 -0.9993 3044756 SPBio_000956 CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P19 compound treatment 9.3174283E7 -9680000.0 -0.55 9.5933256E7 -6110000.0 -0.38 -0.6575 -0.9825 831 SPBio_000957 Nc1nccs1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P20 compound treatment 3.9899973E7 -6.3E7 -3.6 4.2119718E7 -5.99E7 -3.69 -5.1561 -0.9999 1000123 SPBio_000958 CC(=O)OCC(=O)[C@@]1(O)[C@@H](CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P21 compound treatment 9.7351343E7 -5500000.0 -0.31 9.9838179E7 -2210000.0 -0.14 -0.3185 -0.9299 1249 SPBio_000959 C[N+](C)(C)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P22 compound treatment 9.8405092E7 -4450000.0 -0.25 9.8646429E7 -3400000.0 -0.21 -0.3278 -0.9954 1200 SPBio_000960 NC1C[C@H]1c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P23 mock treatment 1.09904631E8 7050000.0 0.4 1.07608334E8 5560000.0 0.34 0.5275 0.9968 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2160 P24 mock treatment 1.17614899E8 1.48E7 0.84 1.15096473E8 1.31E7 0.8 1.1655 0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A01 mock treatment 1.18665798E8 1.89E7 1.08 1.29745787E8 2.66E7 1.64 1.9212 0.9796 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A02 mock treatment 1.15620056E8 1.58E7 0.91 1.19061874E8 1.59E7 0.98 1.3324 0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A03 compound treatment 1.08345949E8 8570000.0 0.49 1.17647193E8 1.45E7 0.89 0.9768 0.9602 1002 SPBio_000961 CN(C)CCOC(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A04 compound treatment 1.00571535E8 795000.0 0.05 1.07502098E8 4320000.0 0.27 0.2204 0.816 778 SPBio_000962 Oc1c(I)cc(I)c2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A05 compound treatment 2.8291605E7 -7.15E7 -4.09 2.9567003E7 -7.36E7 -4.54 -6.0976 -0.9986 979 SPBio_000963 S=C1CC=CC=N1O[Zn]On2ccccc2=S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A06 compound treatment 1.11444976E8 1.17E7 0.67 1.17308179E8 1.41E7 0.87 1.0872 0.9913 1244 SPBio_000964 C[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A07 compound treatment 1.07360571E8 7580000.0 0.43 1.09834522E8 6650000.0 0.41 0.5964 0.9996 1216 SPBio_000965 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2C[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A08 compound treatment 1.08808536E8 9030000.0 0.52 1.09094664E8 5910000.0 0.36 0.6227 0.9855 890 SPBio_000966 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A09 compound treatment 3.4451515E7 -6.53E7 -3.73 3.6423755E7 -6.68E7 -4.12 -5.5498 -0.9988 3177385 SPBio_000967 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A10 compound treatment 6.320367E7 -3.66E7 -2.09 6.2454078E7 -4.07E7 -2.51 -3.2533 -0.9959 1406 SPBio_000968 NC(=O)c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A11 compound treatment 1.01304359E8 1530000.0 0.09 1.0354752E8 365000.0 0.02 0.0776 0.861 858 SPBio_000969 OCC(O)CN1CCN(CC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A12 compound treatment 1.03703438E8 3930000.0 0.22 1.06378335E8 3200000.0 0.2 0.298 0.9979 1123 SPBio_000970 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A13 compound treatment 9.4858428E7 -4920000.0 -0.28 1.05916409E8 2730000.0 0.17 -0.0796 -0.2429 827 SPBio_000971 CCCCC1(COC(=O)CCC(=O)O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A14 compound treatment 9.9989266E7 213000.0 0.01 1.04439812E8 1260000.0 0.08 0.0634 0.8083 3173466 SPBio_000972 [O-][N+](=O)c1ccc(/C=N/N2CC(=O)NC2=O)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A15 compound treatment 9.6272644E7 -3500000.0 -0.2 1.07929973E8 4750000.0 0.29 0.0653 0.1842 770 SPBio_000973 CC(CCc1ccccc1)NC(C)C(O)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A16 compound treatment 9.8950422E7 -826000.0 -0.05 1.06765577E8 3580000.0 0.22 0.1228 0.5437 1077 SPBio_000974 CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A17 compound treatment 9.9597628E7 -179000.0 -0.01 1.11415655E8 8230000.0 0.51 0.3516 0.6927 950 SPBio_000975 Oc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A18 compound treatment 1.13271614E8 1.35E7 0.77 1.19262186E8 1.61E7 0.99 1.2462 0.9923 814 SPBio_000976 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A19 compound treatment 1.09050303E8 9270000.0 0.53 1.14793792E8 1.16E7 0.72 0.8809 0.9891 776 SPBio_000977 NNc1nncc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A20 compound treatment 1.09597057E8 9820000.0 0.56 1.17453676E8 1.43E7 0.88 1.0189 0.9764 3173600 SPBio_000978 Oc1ccc2C[C@H]3N(CC=C)CC[C@]4(C5Oc1c24)[C@@]3(O)CCC5=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A21 compound treatment 1.02432104E8 2660000.0 0.15 1.19547239E8 1.64E7 1.01 0.8206 0.8044 2797 SPBio_000979 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A22 compound treatment 1.1047562E8 1.07E7 0.61 1.19084549E8 1.59E7 0.98 1.1255 0.9742 404 SPBio_000980 CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A23 mock treatment 1.1439564E8 1.46E7 0.84 1.23494177E8 2.03E7 1.25 1.4761 0.9807 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 A24 mock treatment 1.24737174E8 2.5E7 1.43 1.32944185E8 2.98E7 1.83 2.306 0.9923 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B01 mock treatment 1.20053586E8 2.03E7 1.16 1.2821317E8 2.5E7 1.54 1.9105 0.99 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B02 mock treatment 9.7079524E7 -2700000.0 -0.15 1.07148902E8 3970000.0 0.24 0.0639 0.2211 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B03 compound treatment 9.8067603E7 -1710000.0 -0.1 1.01718031E8 -1460000.0 -0.09 -0.1329 -0.9992 1008060 SPBio_000981 C1CCc2nnnn2CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B04 compound treatment 9.1169219E7 -8610000.0 -0.49 9.906285E7 -4120000.0 -0.25 -0.5274 -0.9527 1086 SPBio_000982 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(c1)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B05 compound treatment 1.0107662E8 1300000.0 0.07 1.04007225E8 824000.0 0.05 0.0885 0.9828 1221 SPBio_000983 CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B06 compound treatment 1.01343017E8 1570000.0 0.09 1.05531554E8 2350000.0 0.14 0.1657 0.9733 1184 SPBio_000984 Nc1ncnc2n(cnc12)C3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B07 compound treatment 1.02238583E8 2460000.0 0.14 1.0567125E8 2490000.0 0.15 0.208 0.9991 1058 SPBio_000985 C[C@@]12CCC3C(CCC4=Cc5oncc5C[C@]34C)C2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B08 compound treatment 9.4475547E7 -5300000.0 -0.3 9.9889748E7 -3290000.0 -0.2 -0.3578 -0.981 1434 SPBio_000986 CN1CCN2C(C1)c3ccccc3Cc4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B09 compound treatment 8.4074769E7 -1.57E7 -0.9 9.5908579E7 -7270000.0 -0.45 -0.9516 -0.9486 1302 SPBio_000987 CC(C)CC1N2C(=O)[C@](NC(=O)C3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(OC2(O)[C@@H]7CCCN7C1=O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B10 compound treatment 8.4760304E7 -1.5E7 -0.86 9.799598E7 -5190000.0 -0.32 -0.8329 -0.9095 965 SPBio_000988 C(C1=NCCN1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B11 compound treatment 3.9518185E7 -6.03E7 -3.44 5.3618707E7 -4.96E7 -3.06 -4.5956 -0.9982 2060103 SPBio_000989 COc1ccc2C(=O)[C@@H]3[C@@H](COc4cc(OC)c(OC)cc34)Oc2c1CC=C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B12 compound treatment 1.00213782E8 437000.0 0.03 9.6327897E7 -6860000.0 -0.42 -0.2811 -0.6641 865 SPBio_000990 Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B13 compound treatment 3.1424016E7 -6.84E7 -3.91 3.3089899E7 -7.01E7 -4.32 -5.8175 -0.9987 3045298 SPBio_000991 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B14 compound treatment 7.3905256E7 -2.59E7 -1.48 8.5127187E7 -1.81E7 -1.11 -1.8325 -0.9902 1487 SPBio_000992 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B15 compound treatment 9.6405648E7 -3370000.0 -0.19 9.667104E7 -6510000.0 -0.4 -0.4201 -0.9434 1412 SPBio_000993 CN(C)CCOC(c1ccc(Cl)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B16 compound treatment 9.3878297E7 -5900000.0 -0.34 9.8265451E7 -4920000.0 -0.3 -0.4527 -0.9986 1322 SPBio_000994 COc1cc2ccc(=O)oc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B17 compound treatment 9.0595423E7 -9180000.0 -0.52 1.01553626E8 -1630000.0 -0.1 -0.442 -0.8274 3198425 SPBio_000995 CC1(C)O[C@@H]2CO[C@@]3(COS(=O)(=O)N)OC(C)(C)O[C@H]3[C@@H]2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B18 compound treatment 8.9148048E7 -1.06E7 -0.61 9.9038434E7 -4140000.0 -0.26 -0.6102 -0.9259 1227 SPBio_000996 NCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B19 compound treatment 9.6014835E7 -3760000.0 -0.21 1.02638912E8 -544000.0 -0.03 -0.1757 -0.8077 775 SPBio_000997 NCC(O)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B20 compound treatment 1.08682272E8 8910000.0 0.51 1.14672712E8 1.15E7 0.71 0.8607 0.9869 142 SPBio_000998 CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B21 compound treatment 1.01233625E8 1460000.0 0.08 1.09777406E8 6590000.0 0.41 0.3463 0.8346 2069268 SPBio_000999 CC(=O)O[C@H]1CC[C@]2(C)C3CC[C@@]4(C)C(CCC4=O)C3CC=C2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B22 compound treatment 9.8081523E7 -1690000.0 -0.1 1.05540832E8 2360000.0 0.15 0.0343 0.1963 198 SPBio_001000 CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B23 mock treatment 9.6402887E7 -3370000.0 -0.19 1.07505894E8 4320000.0 0.27 0.0521 0.1584 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 B24 mock treatment 1.17295914E8 1.75E7 1.0 1.24826645E8 2.16E7 1.33 1.6514 0.99 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C01 mock treatment 9.6858802E7 -2920000.0 -0.17 1.06190398E8 3010000.0 0.19 0.0132 0.0529 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C02 mock treatment 8.6243897E7 -1.35E7 -0.77 9.6695371E7 -6490000.0 -0.4 -0.8297 -0.9529 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C03 compound treatment 8.5148662E7 -1.46E7 -0.84 9.3143972E7 -1.0E7 -0.62 -1.0287 -0.989 1370 SPBio_001001 C/C=C(/C(=C/C)/c1ccc(O)cc1)\c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C04 compound treatment 9.0596402E7 -9180000.0 -0.52 9.1083208E7 -1.21E7 -0.75 -0.8984 -0.9852 888 SPBio_001002 CC(C)[N+](C)(CCC(C(=O)N)(c1ccccc1)c2ccccc2)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C05 compound treatment 9.4854768E7 -4920000.0 -0.28 9.6396624E7 -6790000.0 -0.42 -0.4947 -0.9813 1301 SPBio_001003 OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C06 compound treatment 9.029403E7 -9480000.0 -0.54 9.2753641E7 -1.04E7 -0.64 -0.8378 -0.9964 1362 SPBio_001004 COc1c2occc2cc3ccc(=O)oc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C07 compound treatment 9.5204572E7 -4570000.0 -0.26 9.4597883E7 -8590000.0 -0.53 -0.559 -0.9471 1468 SPBio_001005 CCCCC(=O)O[C@H]1CCC2C3CCc4cc(O)ccc4C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C08 compound treatment 8.6325028E7 -1.35E7 -0.77 8.9512926E7 -1.37E7 -0.84 -1.1394 -0.999 82 SPBio_001006 Nc1cc(nc(N)[n+]1[O-])N2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C09 compound treatment 3.4710502E7 -6.51E7 -3.72 3.449865E7 -6.87E7 -4.23 -5.6233 -0.9979 3177451 SPBio_001007 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C10 compound treatment 8.2593098E7 -1.72E7 -0.98 8.6020145E7 -1.72E7 -1.06 -1.4425 -0.9993 1083 SPBio_001008 C(C1=NCCN1)c2cccc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C11 compound treatment 9.5120281E7 -4660000.0 -0.27 9.9370491E7 -3810000.0 -0.24 -0.3543 -0.9981 793 SPBio_001009 CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C12 compound treatment 9.106124E7 -8720000.0 -0.5 8.7787558E7 -1.54E7 -0.95 -1.0233 -0.9547 953 SPBio_001010 C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C13 compound treatment 3.628677E7 -6.35E7 -3.63 3.5657689E7 -6.75E7 -4.16 -5.509 -0.9977 826 SPBio_001011 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)CC[C@]5(C)C4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C14 compound treatment 6.510519E7 -3.47E7 -1.98 6.2788596E7 -4.04E7 -2.49 -3.1618 -0.9936 1000108 SPBio_001012 NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C15 compound treatment 8.3988454E7 -1.58E7 -0.9 8.6411863E7 -1.68E7 -1.03 -1.369 -0.9977 905 SPBio_001013 CO[C@@H]1[C@@H](OC(=O)N)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C16 compound treatment 8.7560319E7 -1.22E7 -0.7 9.2045862E7 -1.11E7 -0.69 -0.9791 -1.0 3173081 SPBio_001014 COCCc1ccc(OCC(O)CNC(C)C)cc1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C17 compound treatment 7.7024318E7 -2.28E7 -1.3 8.2027728E7 -2.12E7 -1.3 -1.8416 -1.0 959 SPBio_001015 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C18 compound treatment 8.0385376E7 -1.94E7 -1.11 8.8364392E7 -1.48E7 -0.91 -1.4295 -0.9954 110 SPBio_001016 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C19 compound treatment 8.7539843E7 -1.22E7 -0.7 9.1221396E7 -1.2E7 -0.74 -1.0159 -0.9997 700 SPBio_001017 CN1C2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C20 compound treatment 9.3546827E7 -6230000.0 -0.36 9.6182885E7 -7000000.0 -0.43 -0.5569 -0.9954 3177386 SPBio_001018 NC[C@H]1O[C@H](OC2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C21 compound treatment 8.8174254E7 -1.16E7 -0.66 9.4569758E7 -8610000.0 -0.53 -0.8443 -0.9939 1127 SPBio_001019 CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C22 compound treatment 9.8452514E7 -1320000.0 -0.08 1.00286564E8 -2900000.0 -0.18 -0.1797 -0.9269 1508 SPBio_001020 CSCCC(NC=O)C(=O)NC(C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C23 mock treatment 8.9805791E7 -9970000.0 -0.57 1.01848832E8 -1330000.0 -0.08 -0.4611 -0.8009 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 C24 mock treatment 1.18724443E8 1.89E7 1.08 1.18953182E8 1.58E7 0.97 1.4531 0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D01 mock treatment 9.5298372E7 -4480000.0 -0.26 1.0435884E8 1180000.0 0.07 -0.1297 -0.4877 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D02 mock treatment 8.4111778E7 -1.57E7 -0.9 9.0793758E7 -1.24E7 -0.76 -1.1731 -0.9969 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D03 compound treatment 3.2539837E7 -6.72E7 -3.84 3.7822253E7 -6.54E7 -4.03 -5.5661 -0.9997 820 SPBio_001021 Oc1ccc(Cl)c2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D04 compound treatment 9.0842753E7 -8930000.0 -0.51 9.4153302E7 -9030000.0 -0.56 -0.7546 -0.9991 861 SPBio_001022 C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D05 compound treatment 9.0491829E7 -9280000.0 -0.53 9.3060712E7 -1.01E7 -0.62 -0.8164 -0.9967 1451 SPBio_001023 CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D06 compound treatment 8.7766127E7 -1.2E7 -0.69 9.2545663E7 -1.06E7 -0.66 -0.949 -0.9997 3055445 SPBio_001024 CC(=O)OC(C)(C)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D07 compound treatment 8.9202301E7 -1.06E7 -0.6 9.1413137E7 -1.18E7 -0.73 -0.9403 -0.9959 1186 SPBio_001025 Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D08 compound treatment 8.8518754E7 -1.13E7 -0.64 9.7000827E7 -6180000.0 -0.38 -0.7244 -0.9688 3172849 SPBio_001026 CN1CCC[C@H]1c2cccnc2.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D09 compound treatment 8.8455202E7 -1.13E7 -0.65 9.1382073E7 -1.18E7 -0.73 -0.9719 -0.9983 2060478 SPBio_001027 CNc1ccc(cc1)C(=O)CC(O)CCC(C)C2OC(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC3(O)CC(O)C(C(CC(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C2C)O3)C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D10 compound treatment 8.9326031E7 -1.05E7 -0.6 8.8537624E7 -1.46E7 -0.9 -1.0607 -0.9799 1087 SPBio_001028 Oc1ccc(Cl)cc1Cc2cc(Cl)ccc2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D11 compound treatment 9.1252489E7 -8520000.0 -0.49 9.3844202E7 -9340000.0 -0.58 -0.7515 -0.9965 4480 SPBio_001029 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D12 compound treatment 9.0324294E7 -9450000.0 -0.54 9.3287833E7 -9900000.0 -0.61 -0.8133 -0.9982 1190 SPBio_001030 Nc1c2C(O)CCCc2nc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D13 compound treatment 8.9536139E7 -1.02E7 -0.59 9.249569E7 -1.07E7 -0.66 -0.8797 -0.9983 682 SPBio_001031 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3C(=O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D14 compound treatment 8.8318138E7 -1.15E7 -0.65 8.7208419E7 -1.6E7 -0.98 -1.1593 -0.9804 1448 SPBio_001032 OC(=O)c1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D15 compound treatment 9.2988084E7 -6790000.0 -0.39 9.0175884E7 -1.3E7 -0.8 -0.8413 -0.9445 1446 SPBio_001033 OC(COc1cccc2oc(cc(=O)c12)C(=O)O)COc3cccc4oc(cc(=O)c34)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D16 compound treatment 9.0885657E7 -8890000.0 -0.51 9.5627748E7 -7560000.0 -0.47 -0.6886 -0.9991 705 SPBio_001034 CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D17 compound treatment 8.9346008E7 -1.04E7 -0.6 8.9151918E7 -1.4E7 -0.86 -1.0331 -0.9835 2069333 SPBio_001035 CC[C@H](/C=C/C(C)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D18 compound treatment 9.2763829E7 -7010000.0 -0.4 9.3142841E7 -1.0E7 -0.62 -0.721 -0.9779 1577 SPBio_001036 OCC(S)CS 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D19 compound treatment 9.9434372E7 -342000.0 -0.02 9.7887699E7 -5300000.0 -0.33 -0.2446 -0.7481 1088 SPBio_001037 CCN(CC)CCOc1ccc(cc1)/C(=C(\Cl)/c2ccccc2)/c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D20 compound treatment 9.3156684E7 -6620000.0 -0.38 9.5573144E7 -7610000.0 -0.47 -0.5992 -0.9943 3177322 SPBio_001038 CC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D21 compound treatment 9.1677516E7 -8100000.0 -0.46 9.3726393E7 -9460000.0 -0.58 -0.7395 -0.9935 689 SPBio_001039 Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C(=O)O)s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D22 compound treatment 2.7735563E7 -7.2E7 -4.12 2.8786773E7 -7.44E7 -4.59 -6.1541 -0.9986 3174103 SPBio_001040 C/C/1=C\CC[C@@]2(C)OC2[C@H]3OC(=O)C(=C)[C@@H]3CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D23 mock treatment 9.88432E7 -933000.0 -0.05 9.9670206E7 -3510000.0 -0.22 -0.1908 -0.8557 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 D24 mock treatment 1.06593668E8 6820000.0 0.39 1.09932129E8 6750000.0 0.42 0.5697 0.9995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E01 mock treatment 9.3079226E7 -6700000.0 -0.38 9.9819855E7 -3360000.0 -0.21 -0.4172 -0.9585 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E02 mock treatment 9.6739845E7 -3040000.0 -0.17 9.4265942E7 -8920000.0 -0.55 -0.5114 -0.8872 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E03 compound treatment 9.4438786E7 -5340000.0 -0.31 1.00160869E8 -3020000.0 -0.19 -0.3474 -0.972 1265 SPBio_001041 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4c(Cl)cccc4Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E04 compound treatment 9.0282409E7 -9490000.0 -0.54 9.6526248E7 -6660000.0 -0.41 -0.6738 -0.9905 1479 SPBio_001042 CC(C)NCC(O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E05 compound treatment 9.0380795E7 -9400000.0 -0.54 9.7751596E7 -5430000.0 -0.33 -0.6164 -0.9742 1441 SPBio_001043 CN1CCC(CC1)OC(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E06 compound treatment 8.9610652E7 -1.02E7 -0.58 9.1406157E7 -1.18E7 -0.73 -0.9241 -0.9939 1009 SPBio_001044 C[N+]1(C)C2CC(CC1C3OC32)OC(=O)[C@@H](CO)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E07 compound treatment 3.1092493E7 -6.87E7 -3.93 3.2154025E7 -7.1E7 -4.38 -5.8717 -0.9985 1363 SPBio_001045 CCOC(=O)CCC(=O)O[C@@H]1[C@H](C[C@@H](C)O[C@H]1O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E08 compound treatment 8.2572441E7 -1.72E7 -0.98 8.384768E7 -1.93E7 -1.19 -1.538 -0.9954 1000107 SPBio_001046 CC(=O)O[C@]1(CCC2C3CCC4=CC(=O)CC[C@@H]4C3CC[C@@]21C)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E09 compound treatment 8.8356799E7 -1.14E7 -0.65 9.2271513E7 -1.09E7 -0.67 -0.9371 -0.9999 727 SPBio_001047 CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E10 compound treatment 8.6519059E7 -1.33E7 -0.76 8.7689629E7 -1.55E7 -0.96 -1.2111 -0.9934 879 SPBio_001048 NC[C@H](O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E11 compound treatment 8.8700239E7 -1.11E7 -0.63 9.0794308E7 -1.24E7 -0.76 -0.9876 -0.9957 1222 SPBio_001049 Cn1cnc2n(C)c(=O)[nH]c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E12 compound treatment 8.9360596E7 -1.04E7 -0.6 9.0850953E7 -1.23E7 -0.76 -0.9585 -0.9927 3173462 SPBio_001050 C[C@H](COc1ccccc1)N[C@@H](C)[C@H](O)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E13 compound treatment 9.0494445E7 -9280000.0 -0.53 9.0890203E7 -1.23E7 -0.76 -0.9109 -0.9848 706 SPBio_001051 Nc1ccc(cc1)S(=O)(=O)Nc2cnc3ccccc3n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E14 compound treatment 8.8397291E7 -1.14E7 -0.65 8.756882E7 -1.56E7 -0.96 -1.1404 -0.9818 1169 SPBio_001052 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@H]34)C2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E15 compound treatment 8.8415745E7 -1.14E7 -0.65 9.1623388E7 -1.16E7 -0.71 -0.963 -0.9989 3177388 SPBio_001053 COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E16 compound treatment 9.1746837E7 -8030000.0 -0.46 9.4080716E7 -9100000.0 -0.56 -0.7212 -0.995 1000139 SPBio_001054 CO[C@]1(NC(=O)C(C(=O)O)c2ccc(O)cc2)[C@H]3OCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E17 compound treatment 3.4906437E7 -6.49E7 -3.71 3.5960534E7 -6.72E7 -4.14 -5.5516 -0.9985 876 SPBio_001055 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E18 compound treatment 9.0252146E7 -9520000.0 -0.54 9.1111687E7 -1.21E7 -0.74 -0.9111 -0.9882 800 SPBio_001056 C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E19 compound treatment 8.3839992E7 -1.59E7 -0.91 8.6686644E7 -1.65E7 -1.02 -1.3631 -0.9985 756 SPBio_001057 CCCCCCc1ccc(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E20 compound treatment 9.5014133E7 -4760000.0 -0.27 9.7271035E7 -5910000.0 -0.36 -0.4501 -0.9897 1064 SPBio_001058 [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E21 compound treatment 9.4631416E7 -5140000.0 -0.29 9.5172468E7 -8010000.0 -0.49 -0.5571 -0.9693 1174 SPBio_001059 CN(C)CCCN1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E22 compound treatment 8.4492749E7 -1.53E7 -0.87 9.2019034E7 -1.12E7 -0.69 -1.1043 -0.993 2935 SPBio_001060 CC(=O)NCc1c(I)c(NC(=O)C)c(I)c(C(=O)O)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E23 mock treatment 1.01333647E8 1560000.0 0.09 9.7939199E7 -5240000.0 -0.32 -0.1656 -0.494 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 E24 mock treatment 1.03475485E8 3700000.0 0.21 1.07370864E8 4190000.0 0.26 0.332 0.9951 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F01 mock treatment 9.9365957E7 -410000.0 -0.02 1.06715935E8 3530000.0 0.22 0.1374 0.6273 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F02 mock treatment 9.5187284E7 -4590000.0 -0.26 1.00418273E8 -2760000.0 -0.17 -0.306 -0.9782 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F03 compound treatment 9.0701927E7 -9070000.0 -0.52 9.7568552E7 -5610000.0 -0.35 -0.6114 -0.9807 1114 SPBio_001061 NS(=O)(=O)c1cc2c(N=C(CSCc3ccccc3)NS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F04 compound treatment 8.8188816E7 -1.16E7 -0.66 9.5002285E7 -8180000.0 -0.5 -0.8249 -0.991 957 SPBio_001062 NC(COC(=O)C=[N+]=[N-])C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F05 compound treatment 8.6866684E7 -1.29E7 -0.74 9.3775631E7 -9410000.0 -0.58 -0.9318 -0.9929 1001638 SPBio_001063 CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F06 compound treatment 8.8922742E7 -1.09E7 -0.62 9.3415333E7 -9770000.0 -0.6 -0.8644 -0.9999 3054072 SPBio_001064 OC(=O)CCCCCCCCCCCCC1CCC=C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F07 compound treatment 8.673415E7 -1.3E7 -0.75 9.0141233E7 -1.3E7 -0.8 -1.0955 -0.9993 1337 SPBio_001065 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F08 compound treatment 8.3491745E7 -1.63E7 -0.93 8.3418554E7 -1.98E7 -1.22 -1.5196 -0.9912 1020088 SPBio_001066 NNCc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F09 compound treatment 8.4324012E7 -1.55E7 -0.88 8.9217938E7 -1.4E7 -0.86 -1.2332 -0.9999 3173625 SPBio_001067 Nc1nc2n(cnc2c(=O)[nH]1)C3C[C@H](O)[C@@H](CO)O3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F10 compound treatment 8.6533059E7 -1.32E7 -0.76 9.0756099E7 -1.24E7 -0.77 -1.0769 -1.0 2508 SPBio_001068 OC(=O)COc1cc(Cl)c(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F11 compound treatment 3.2550275E7 -6.72E7 -3.84 3.3918681E7 -6.93E7 -4.27 -5.7358 -0.9986 1031842 SPBio_001069 CC(=O)Oc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F12 compound treatment 8.4937049E7 -1.48E7 -0.85 8.6634157E7 -1.65E7 -1.02 -1.321 -0.9958 2477 SPBio_001070 CCOP(=S)(OCC)SCSP(=S)(OCC)OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F13 compound treatment 8.6790178E7 -1.3E7 -0.74 8.9038091E7 -1.41E7 -0.87 -1.1413 -0.9968 894 SPBio_001071 ClCCN(CCCl)P1(=O)NCCCO1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F14 compound treatment 8.9596848E7 -1.02E7 -0.58 9.1448766E7 -1.17E7 -0.72 -0.9228 -0.9942 2476 SPBio_001072 CCOP(=S)(OCC)Oc1cc(C)nc(n1)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F15 compound treatment 8.8981969E7 -1.08E7 -0.62 9.0683612E7 -1.25E7 -0.77 -0.981 -0.9939 1125 SPBio_001073 CCOC(=O)NNc1nncc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F16 compound treatment 8.4757303E7 -1.5E7 -0.86 8.3359487E7 -1.98E7 -1.22 -1.471 -0.9851 2484 SPBio_001074 COP(=O)(OC)OC=C(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F17 compound treatment 8.5175304E7 -1.46E7 -0.83 8.33908E7 -1.98E7 -1.22 -1.4528 -0.9828 964 SPBio_001075 CN(C)N=Nc1[nH]cnc1C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F18 compound treatment 8.2944788E7 -1.68E7 -0.96 3.1023529E7 -7.22E7 -4.45 -3.8255 -0.8406 2487 SPBio_001076 CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F19 compound treatment 9.6641544E7 -3130000.0 -0.18 9.687463E7 -6310000.0 -0.39 -0.4017 -0.9381 1480 SPBio_001077 Clc1ccc2oc(=O)[nH]c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F20 compound treatment 9.4837299E7 -4940000.0 -0.28 9.9326088E7 -3860000.0 -0.24 -0.3677 -0.9964 2496 SPBio_001078 CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F21 compound treatment 9.6033238E7 -3740000.0 -0.21 9.7050825E7 -6130000.0 -0.38 -0.4186 -0.9637 2060468 SPBio_001079 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F22 compound treatment 9.0186815E7 -9590000.0 -0.55 9.030809E7 -1.29E7 -0.79 -0.9487 -0.9837 2523 SPBio_001080 CCOP(=S)(OCC)Oc1nc(Cl)c(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F23 mock treatment 9.4905461E7 -4870000.0 -0.28 9.2819283E7 -1.04E7 -0.64 -0.6486 -0.9307 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 F24 mock treatment 1.023173E8 2540000.0 0.15 1.04883964E8 1700000.0 0.1 0.1768 0.9872 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G01 mock treatment 8.8441303E7 -1.13E7 -0.65 9.6098735E7 -7080000.0 -0.44 -0.7669 -0.9816 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G02 mock treatment 9.4271349E7 -5500000.0 -0.31 9.4796312E7 -8390000.0 -0.52 -0.588 -0.9716 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G03 compound treatment 9.2767354E7 -7010000.0 -0.4 1.01752348E8 -1430000.0 -0.09 -0.3456 -0.8426 915 SPBio_001081 OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G04 compound treatment 9.0359745E7 -9420000.0 -0.54 9.4625464E7 -8560000.0 -0.53 -0.7535 -0.9999 2060472 SPBio_001082 C[C@@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C2CC[C@@]1(O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G05 compound treatment 8.8573788E7 -1.12E7 -0.64 9.5101523E7 -8080000.0 -0.5 -0.805 -0.9923 3173092 SPBio_001083 CN(C)CCOC(c1ccccc1)c2ccccc2.Cn1c(=O)n(C)c2nc(Cl)[nH]c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G06 compound treatment 8.6649275E7 -1.31E7 -0.75 9.2420667E7 -1.08E7 -0.66 -0.9996 -0.9981 815 SPBio_001084 CCN(CC)C(=O)c1cccc(C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G07 compound treatment 8.4906815E7 -1.49E7 -0.85 8.791086E7 -1.53E7 -0.94 -1.2666 -0.9987 3174481 SPBio_001085 CNC[C@@H](O)c1ccc(O)c(O)c1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G08 compound treatment 8.7174261E7 -1.26E7 -0.72 9.1262506E7 -1.19E7 -0.73 -1.0289 -0.9999 772 SPBio_001086 CCN1CCCC(C1)OC(=O)C(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G09 compound treatment 8.557993E7 -1.42E7 -0.81 8.998897E7 -1.32E7 -0.81 -1.1488 -1.0 803 SPBio_001087 CCc1cc(ccn1)C(=S)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G10 compound treatment 8.5165745E7 -1.46E7 -0.84 8.9292796E7 -1.39E7 -0.86 -1.1959 -0.9999 904 SPBio_001088 NC(=O)CN1CCCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G11 compound treatment 8.5397522E7 -1.44E7 -0.82 9.0259557E7 -1.29E7 -0.8 -1.1444 -0.9999 1150 SPBio_001089 OC(=O)CCCCCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G12 compound treatment 8.3565427E7 -1.62E7 -0.93 8.2249968E7 -2.09E7 -1.29 -1.5675 -0.9868 1111 SPBio_001090 CCC(C)C1NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(CCNC(=O)C(NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(NC1=O)C(C)CC)C(C)O)NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(NC(=O)C(CCNCS(=O)(=O)O)NC(=O)CCCCC(C)C)C(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G13 compound treatment 8.3756671E7 -1.6E7 -0.92 8.915888E7 -1.4E7 -0.86 -1.2587 -0.9996 790 SPBio_001091 COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G14 compound treatment 4.6279723E7 -5.35E7 -3.06 4.8060408E7 -5.51E7 -3.4 -4.5646 -0.9986 1000054 SPBio_001092 CC(C)CC1NC(=O)C(CCCN)NC(=O)C(NC(=O)C2CCCN2C(=O)C(Cc3ccccc3)NC(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(NC(=O)C4CCCN4C(=O)C(Cc5ccccc5)NC1=O)C(C)C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G15 compound treatment 8.9704685E7 -1.01E7 -0.58 9.1129551E7 -1.21E7 -0.74 -0.9324 -0.992 809 SPBio_001093 CNCCC=C1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G16 compound treatment 4.2440444E7 -5.73E7 -3.28 4.3414932E7 -5.98E7 -3.68 -4.9222 -0.9983 464 SPBio_001094 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G17 compound treatment 9.3236519E7 -6540000.0 -0.37 9.6876266E7 -6310000.0 -0.39 -0.5392 -0.9998 1181 SPBio_001095 Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G18 compound treatment 9.133985E7 -8440000.0 -0.48 9.5025875E7 -8160000.0 -0.5 -0.6965 -0.9998 1257 SPBio_001096 CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G19 compound treatment 9.2422688E7 -7350000.0 -0.42 9.5569865E7 -7610000.0 -0.47 -0.629 -0.9985 948 SPBio_001097 O=C1C(C(=O)c2ccccc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G20 compound treatment 9.4002616E7 -5770000.0 -0.33 9.0369039E7 -1.28E7 -0.79 -0.7919 -0.925 3046211 SPBio_001098 CCC(C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C/C=C(\C)/[C@@H](OC4C[C@H](OC)C(O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2)C=C[C@@H]1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G21 compound treatment 9.9692242E7 -84000.0 0.0 1.00655455E8 -2530000.0 -0.16 -0.1136 -0.7286 3174102 SPBio_001099 OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G22 compound treatment 1.03750224E8 3970000.0 0.23 1.01634832E8 -1550000.0 -0.1 0.0931 0.378 900 SPBio_001100 CN1C(=C(O)c2sccc2S1(=O)=O)C(=O)Nc3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G23 mock treatment 9.0274936E7 -9500000.0 -0.54 9.6847265E7 -6340000.0 -0.39 -0.6601 -0.9869 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 G24 mock treatment 1.09001458E8 9230000.0 0.53 1.06060703E8 2880000.0 0.18 0.4982 0.8957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H01 mock treatment 9.2005017E7 -7770000.0 -0.44 1.01641654E8 -1540000.0 -0.1 -0.3812 -0.8394 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H02 mock treatment 9.2196381E7 -7580000.0 -0.43 9.5218899E7 -7960000.0 -0.49 -0.6535 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H03 compound treatment 9.0535501E7 -9240000.0 -0.53 9.9013788E7 -4170000.0 -0.26 -0.5552 -0.9452 1104 SPBio_001101 C[C@H](CCC(=O)O)[C@H]1CCC2C3C(CC(=O)[C@]12C)[C@@]4(C)CCC(=O)CC4CC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H04 compound treatment 8.7727658E7 -1.2E7 -0.69 9.5349173E7 -7830000.0 -0.48 -0.8284 -0.9849 2529 SPBio_001102 COP(=S)(OC)Oc1ccc(SC)c(C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H05 compound treatment 3.6872726E7 -6.29E7 -3.6 3.8131223E7 -6.51E7 -4.01 -5.3775 -0.9985 1430 SPBio_001103 CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H06 compound treatment 8.284721E7 -1.69E7 -0.97 9.1705083E7 -1.15E7 -0.71 -1.1844 -0.9882 2531 SPBio_001104 CNC(=O)Oc1ccccc1OC(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H07 compound treatment 8.3848669E7 -1.59E7 -0.91 9.0046807E7 -1.31E7 -0.81 -1.2163 -0.9983 1409 SPBio_001105 CCCC(C)(COC(=O)N)COC(=O)NC(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H08 compound treatment 8.057345E7 -1.92E7 -1.1 8.372596E7 -1.95E7 -1.2 -1.6241 -0.999 2533 SPBio_001106 Clc1ccc(cc1)C(c2ccc(Cl)cc2)C(Cl)(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H09 compound treatment 7.6562953E7 -2.32E7 -1.33 8.1933614E7 -2.12E7 -1.31 -1.8643 -1.0 1587 SPBio_001107 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@@H]4O[C@H](CO)[C@@H](O)C[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H10 compound treatment 8.3269464E7 -1.65E7 -0.94 9.0712724E7 -1.25E7 -0.77 -1.2106 -0.9948 3177463 SPBio_001108 CC1=C(N2C(SC1)[C@H](NC(=O)[C@H](N)C3=CCC=CC3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H11 compound treatment 4.7228579E7 -5.25E7 -3.0 4.8597239E7 -5.46E7 -3.36 -4.5029 -0.9984 745 SPBio_001109 CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H12 compound treatment 8.1960901E7 -1.78E7 -1.02 8.5128885E7 -1.81E7 -1.11 -1.5069 -0.999 835 SPBio_001110 CC(=O)OC1CN2CCC1CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H13 compound treatment 8.5118311E7 -1.47E7 -0.84 8.8116452E7 -1.51E7 -0.93 -1.2491 -0.9987 436 SPBio_001111 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H14 compound treatment 8.6495194E7 -1.33E7 -0.76 9.1126634E7 -1.21E7 -0.74 -1.0622 -0.9999 4164 SPBio_001112 CC(C(=O)O)c1ccc2c(c1)[nH]c3ccc(Cl)cc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H15 compound treatment 8.6389455E7 -1.34E7 -0.77 9.1114883E7 -1.21E7 -0.74 -1.067 -0.9999 1575 SPBio_001113 CNC1=Nc2ccc(Cl)cc2C(=[N+]([O-])C1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H16 compound treatment 8.2610446E7 -1.72E7 -0.98 8.5619771E7 -1.76E7 -1.08 -1.4593 -0.9988 2060327 SPBio_001114 COc1cc2CCN(C)[C@H]3Oc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c32)cc7)N(C)CCc6cc5OC)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H17 compound treatment 2.7781219E7 -7.2E7 -4.11 2.8536782E7 -7.46E7 -4.6 -6.1632 -0.9984 3055248 SPBio_001115 C=CC(C1=CC(=O)C=CC1=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H18 compound treatment 9.2592336E7 -7180000.0 -0.41 9.6105784E7 -7080000.0 -0.44 -0.5988 -0.9995 1522 SPBio_001116 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H19 compound treatment 9.275238E7 -7020000.0 -0.4 9.1656118E7 -1.15E7 -0.71 -0.7863 -0.9635 729 SPBio_001117 OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H20 compound treatment 2.7999768E7 -7.18E7 -4.1 2.8836676E7 -7.43E7 -4.58 -6.1413 -0.9985 3177316 SPBio_001118 C[C@@H]1O[C@@H](O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H21 compound treatment 8.9615897E7 -1.02E7 -0.58 9.1047945E7 -1.21E7 -0.75 -0.9395 -0.9922 1113841 SPBio_001119 Oc1ccc2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H22 compound treatment 3.5530723E7 -6.42E7 -3.67 3.5633806E7 -6.75E7 -4.16 -5.5406 -0.998 3063989 SPBio_001120 C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@@]42OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]4[C@@H]5O[C@@]51C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H23 mock treatment 1.04384781E8 4610000.0 0.26 1.0108579E8 -2100000.0 -0.13 0.0948 0.3232 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 H24 mock treatment 1.0531265E8 5540000.0 0.32 1.02238728E8 -944000.0 -0.06 0.1826 0.5675 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I01 mock treatment 9.2651952E7 -7120000.0 -0.41 1.00751393E8 -2430000.0 -0.15 -0.3939 -0.9079 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I02 mock treatment 9.5959974E7 -3820000.0 -0.22 9.8260048E7 -4920000.0 -0.3 -0.3688 -0.9869 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I03 compound treatment 9.4260026E7 -5520000.0 -0.32 9.9765453E7 -3420000.0 -0.21 -0.3719 -0.9808 969 SPBio_001121 CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I04 compound treatment 9.0229157E7 -9550000.0 -0.55 9.6074186E7 -7110000.0 -0.44 -0.6957 -0.9941 2558 SPBio_001122 c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I05 compound treatment 8.7419688E7 -1.24E7 -0.71 9.5137361E7 -8050000.0 -0.5 -0.8501 -0.985 3174228 SPBio_001123 CN[C@H]1C(O)C(O)C(CO)OC1OC2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)OC(C)[C@]2(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I06 compound treatment 8.5377391E7 -1.44E7 -0.82 9.1848139E7 -1.13E7 -0.7 -1.076 -0.9967 1009654 SPBio_001124 COc1ccc(cc1OC)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I07 compound treatment 8.4653032E7 -1.51E7 -0.86 9.1754852E7 -1.14E7 -0.7 -1.1093 -0.9948 1224 SPBio_001125 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@H]1OC(=O)CCC5CCCC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I08 compound treatment 8.2891918E7 -1.69E7 -0.96 8.7552521E7 -1.56E7 -0.96 -1.3636 -1.0 1012 SPBio_001126 Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I09 compound treatment 7.0294352E7 -2.95E7 -1.68 7.1616158E7 -3.16E7 -1.95 -2.5674 -0.9974 1139 SPBio_001127 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I10 compound treatment 2.8434458E7 -7.13E7 -4.08 2.9290174E7 -7.39E7 -4.55 -6.1039 -0.9985 3172974 SPBio_001128 C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)C4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I11 compound treatment 8.1301274E7 -1.85E7 -1.06 8.7551834E7 -1.56E7 -0.96 -1.4279 -0.999 1188 SPBio_001129 NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I12 compound treatment 8.2833048E7 -1.69E7 -0.97 8.7004999E7 -1.62E7 -1.0 -1.3899 -0.9999 1206 SPBio_001130 CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@@]53C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I13 compound treatment 8.0337877E7 -1.94E7 -1.11 8.1648571E7 -2.15E7 -1.33 -1.7242 -0.9961 1215 SPBio_001131 CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I14 compound treatment 8.2047491E7 -1.77E7 -1.01 8.7357056E7 -1.58E7 -0.98 -1.4063 -0.9998 3078331 SPBio_001132 OC(=O)c1cccc(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I15 compound treatment 8.2801134E7 -1.7E7 -0.97 8.6936933E7 -1.62E7 -1.0 -1.3941 -0.9999 1219 SPBio_001133 CC[C@@]12CCC3C(CCC4=CC(=O)CC[C@H]34)C2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I16 compound treatment 8.341945E7 -1.64E7 -0.93 8.4730713E7 -1.85E7 -1.14 -1.4653 -0.9953 810 SPBio_001134 CCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I17 compound treatment 8.6926536E7 -1.28E7 -0.73 9.0996843E7 -1.22E7 -0.75 -1.0505 -0.9999 838 SPBio_001135 COc1ccc(C(=O)c2ccccc2)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I18 compound treatment 3.5468745E7 -6.43E7 -3.68 3.5804276E7 -6.74E7 -4.15 -5.5357 -0.9981 704 SPBio_001136 CN(C)c1ccc(cc1)C(=C2C=CC(=[N+](C)C)C=C2)c3ccc(cc3)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I19 compound treatment 9.2403227E7 -7370000.0 -0.42 9.2649267E7 -1.05E7 -0.65 -0.7571 -0.9781 3273 SPBio_001137 NNCCc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I20 compound treatment 9.3215957E7 -6560000.0 -0.37 9.6620653E7 -6560000.0 -0.4 -0.5512 -0.9993 1585 SPBio_001138 CC(C)c1ccc(C)c2ccc(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I21 compound treatment 9.4166945E7 -5610000.0 -0.32 9.2816463E7 -1.04E7 -0.64 -0.6785 -0.9491 1131 SPBio_001139 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I22 compound treatment 9.0699184E7 -9080000.0 -0.52 8.6693648E7 -1.65E7 -1.02 -1.0856 -0.9513 1000377 SPBio_001140 CC(C)c1nc(nc(c1/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c2ccc(F)cc2)N(C)S(=O)(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I23 mock treatment 9.1334438E7 -8440000.0 -0.48 9.5614034E7 -7570000.0 -0.47 -0.6711 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 I24 mock treatment 1.02312459E8 2540000.0 0.14 1.04643532E8 1460000.0 0.09 0.1662 0.9738 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J01 mock treatment 9.0838686E7 -8940000.0 -0.51 1.01227413E8 -1960000.0 -0.12 -0.4464 -0.8506 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J02 mock treatment 9.4001095E7 -5780000.0 -0.33 9.4133574E7 -9050000.0 -0.56 -0.6278 -0.9686 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J03 compound treatment 9.0602623E7 -9170000.0 -0.52 9.6614943E7 -6570000.0 -0.4 -0.657 -0.9918 1000134 SPBio_001141 Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J04 compound treatment 8.5096818E7 -1.47E7 -0.84 8.8563673E7 -1.46E7 -0.9 -1.2305 -0.9994 1000093 SPBio_001142 CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J05 compound treatment 8.72845E7 -1.25E7 -0.71 9.1262337E7 -1.19E7 -0.73 -1.0244 -0.9999 1113 SPBio_001143 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(=O)O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J06 compound treatment 8.1215292E7 -1.86E7 -1.06 8.7790311E7 -1.54E7 -0.95 -1.421 -0.9985 2141064 SPBio_001144 COC1=C[C@@H]2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J07 compound treatment 7.6619069E7 -2.32E7 -1.32 8.0537971E7 -2.26E7 -1.4 -1.9229 -0.9996 3055370 SPBio_001145 COC(=O)c1c(C)c2Oc3c(Cl)c(OC(=O)C)c(Cl)c(C)c3C(=O)Oc2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J08 compound treatment 8.0763172E7 -1.9E7 -1.09 8.9258478E7 -1.39E7 -0.86 -1.3753 -0.9932 3079387 SPBio_001146 CN(/C=N/c1ccc(C)cc1C)/C=N/c2ccc(C)cc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J09 compound treatment 8.1760849E7 -1.8E7 -1.03 9.300777E7 -1.02E7 -0.63 -1.1716 -0.9718 2069224 SPBio_001147 COc1ccc(cc1)c2c(O)c3cc4CCC(C)(C)Oc4c(CC=C(C)C)c3oc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J10 compound treatment 7.6755327E7 -2.3E7 -1.32 8.3572719E7 -1.96E7 -1.21 -1.7851 -0.9991 3177525 SPBio_001148 NCCCC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J11 compound treatment 7.7059383E7 -2.27E7 -1.3 8.1634812E7 -2.15E7 -1.33 -1.8573 -0.9999 2060359 SPBio_001149 COc1ccc(cc1)c2c(O)c3c(OC)c4C=CC(C)(C)Oc4cc3oc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J12 compound treatment 4.8894645E7 -5.09E7 -2.91 4.6525914E7 -5.67E7 -3.49 -4.5258 -0.9959 885 SPBio_001150 Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J13 compound treatment 2.7758446E7 -7.2E7 -4.12 2.8693912E7 -7.45E7 -4.59 -6.1572 -0.9985 2060346 SPBio_001151 CC(=O)Oc1cc2c(CC=C3[C@@]2(C)CC[C@@]4(C)C5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O)c(C)c1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J14 compound treatment 8.2382839E7 -1.74E7 -0.99 8.5450226E7 -1.77E7 -1.09 -1.4758 -0.9989 3046390 SPBio_001152 CCC(=O)O[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J15 compound treatment 7.4237074E7 -2.55E7 -1.46 7.8257361E7 -2.49E7 -1.54 -2.1186 -0.9997 2060444 SPBio_001153 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J16 compound treatment 8.0717346E7 -1.91E7 -1.09 7.1605497E7 -3.16E7 -1.95 -2.1466 -0.9624 3198427 SPBio_001154 CCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J17 compound treatment 8.8074451E7 -1.17E7 -0.67 9.2338709E7 -1.08E7 -0.67 -0.9456 -1.0 2060377 SPBio_001155 COc1c(ccc2OC(C)(C)CCc12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J18 compound treatment 8.5944148E7 -1.38E7 -0.79 9.369829E7 -9480000.0 -0.58 -0.9724 -0.989 1072288 SPBio_001156 CC(=C)C1CNC(C1CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J19 compound treatment 9.2764773E7 -7010000.0 -0.4 9.4377986E7 -8810000.0 -0.54 -0.6671 -0.9889 2060190 SPBio_001157 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4C(=O)[C@@H](OC(=O)C)[C@]23C)OC(=O)C)O[C@@]61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J20 compound treatment 9.3967471E7 -5810000.0 -0.33 9.5237825E7 -7950000.0 -0.49 -0.5811 -0.9821 3198428 SPBio_001158 CCOC(=O)[C@H](CCc1ccccc1)N[C@H](C)C(=O)N2[C@@H](CC3CCCCC32)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J21 compound treatment 9.3916562E7 -5860000.0 -0.33 9.5943099E7 -7240000.0 -0.45 -0.5524 -0.99 1312 SPBio_001159 C[As](=O)(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J22 compound treatment 9.6946468E7 -2830000.0 -0.16 9.5984496E7 -7200000.0 -0.44 -0.4281 -0.9065 1078453 SPBio_001160 Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J23 mock treatment 1.03909488E8 4130000.0 0.24 1.07209665E8 4030000.0 0.25 0.3425 0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 J24 mock treatment 1.09070711E8 9290000.0 0.53 1.04150745E8 968000.0 0.06 0.4178 0.7816 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K01 mock treatment 9.674878E7 -3030000.0 -0.17 1.04277219E8 1090000.0 0.07 -0.0747 -0.402 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K02 mock treatment 8.6178459E7 -1.36E7 -0.78 8.8112203E7 -1.51E7 -0.93 -1.2064 -0.9961 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K03 compound treatment 9.3628212E7 -6150000.0 -0.35 9.155264E7 -1.16E7 -0.72 -0.7554 -0.9461 1024 SPBio_001161 c1ccc2c(c1)sc3ccccc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K04 compound treatment 7.7225401E7 -2.26E7 -1.29 7.6991337E7 -2.62E7 -1.61 -2.053 -0.9938 2566 SPBio_001162 CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K05 compound treatment 8.4336569E7 -1.54E7 -0.88 8.531526E7 -1.79E7 -1.1 -1.4028 -0.994 1518 SPBio_001163 OC(=O)c1cc(ccc1O)c2ccc(F)cc2F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K06 compound treatment 8.1235439E7 -1.85E7 -1.06 7.9981659E7 -2.32E7 -1.43 -1.7606 -0.9891 3198423 SPBio_001164 CO/N=C/1\CN(CC1CN)c2nc3n(cc(C(=O)O)c(=O)c3cc2F)C4CC4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K07 compound treatment 8.4978947E7 -1.48E7 -0.85 9.047819E7 -1.27E7 -0.78 -1.1518 -0.9993 1240 SPBio_001165 CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K08 compound treatment 6.1076928E7 -3.87E7 -2.21 6.5087757E7 -3.81E7 -2.35 -3.2244 -0.9996 2060461 SPBio_001166 COc1ccc(C2COc3c(OC)c(O)ccc3C2)c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K09 compound treatment 7.7363467E7 -2.24E7 -1.28 8.2595156E7 -2.06E7 -1.27 -1.8031 -1.0 1176 SPBio_001167 CC[C@@H](CO)NCCN[C@@H](CC)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K10 compound treatment 7.9842694E7 -1.99E7 -1.14 8.2599655E7 -2.06E7 -1.27 -1.7027 -0.9986 2560 SPBio_001168 Cc1ccc2cc3c(ccc4ccccc43)c5CCc1c52 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K11 compound treatment 7.8611908E7 -2.12E7 -1.21 8.195594E7 -2.12E7 -1.31 -1.7805 -0.9992 3043753 SPBio_001169 [O-][N+](=O)c1ccc(/C=N/N2CCOC2=O)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K12 compound treatment 8.1371448E7 -1.84E7 -1.05 8.4526221E7 -1.87E7 -1.15 -1.557 -0.999 2060305 SPBio_001170 CCCCC[C@H](CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K13 compound treatment 4.5085185E7 -5.47E7 -3.13 4.4907573E7 -5.83E7 -3.59 -4.7503 -0.9976 1000104 SPBio_001171 Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K14 compound treatment 6.9972421E7 -2.98E7 -1.7 7.07492E7 -3.24E7 -2.0 -2.6182 -0.9968 1661997 SPBio_001172 CC12CCC3C(CCc4cc(OC(=O)c5ccccc5)ccc34)C2CCC1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K15 compound treatment 8.6606861E7 -1.32E7 -0.75 8.7132037E7 -1.61E7 -0.99 -1.2318 -0.9909 747 SPBio_001173 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K16 compound treatment 8.751183E7 -1.23E7 -0.7 8.9936165E7 -1.32E7 -0.82 -1.073 -0.9971 796 SPBio_001174 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K17 compound treatment 8.8168581E7 -1.16E7 -0.66 9.4399849E7 -8780000.0 -0.54 -0.8519 -0.9949 996 SPBio_001175 NCCc1cc(O)c(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K18 compound treatment 9.1908311E7 -7870000.0 -0.45 9.408344E7 -9100000.0 -0.56 -0.7146 -0.994 3173859 SPBio_001176 CC(C)CC(=O)OC1C(O[C@@H]2C[C@H]([C@H]3CC[C@]4(CC5CC[C@H]4[C@]3(C)C2)[C@@H](O)C5=C)C(=O)O)OC(CO)C(OS(=O)(=O)O)C1OS(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K19 compound treatment 9.1437733E7 -8340000.0 -0.48 9.2500199E7 -1.07E7 -0.66 -0.8026 -0.9874 958 SPBio_001177 NC(=O)NC(=O)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K20 compound treatment 7.9276036E7 -2.05E7 -1.17 6.3965017E7 -3.92E7 -2.42 -2.5379 -0.9447 1324 SPBio_001178 CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K21 compound treatment 5.6756411E7 -4.3E7 -2.46 5.9581613E7 -4.36E7 -2.69 -3.639 -0.999 881 SPBio_001179 CC12C[C@H](O)C3C(CCC4=CC(=O)CCC34C)C2CC[C@]1(O)C(=O)COP(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K22 compound treatment 9.1276968E7 -8500000.0 -0.49 9.0365739E7 -1.28E7 -0.79 -0.9022 -0.9727 1000411 SPBio_001180 CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K23 mock treatment 9.9442918E7 -333000.0 -0.02 9.4472585E7 -8710000.0 -0.54 -0.3931 -0.7317 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 K24 mock treatment 1.03180452E8 3400000.0 0.19 9.9736703E7 -3450000.0 -0.21 -0.0126 -0.0439 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L01 mock treatment 9.6208809E7 -3570000.0 -0.2 1.02743277E8 -440000.0 -0.03 -0.1633 -0.7941 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L02 mock treatment 8.0606726E7 -1.92E7 -1.1 8.8570733E7 -1.46E7 -0.9 -1.4116 -0.9953 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L03 compound treatment 8.7812181E7 -1.2E7 -0.68 9.5313617E7 -7870000.0 -0.49 -0.8265 -0.9859 3198426 SPBio_001181 NCC(CC(=O)O)c1ccc(Cl)s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L04 compound treatment 7.5592052E7 -2.42E7 -1.38 7.9699119E7 -2.35E7 -1.45 -2.001 -0.9997 3069053 SPBio_001182 CCOC(=O)n1ccn(C)c1=S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L05 compound treatment 8.7130296E7 -1.26E7 -0.72 9.2492682E7 -1.07E7 -0.66 -0.977 -0.9989 3202 SPBio_001183 COc1ccccc1N2CCN(CCCNc3cc(=O)n(C)c(=O)n3C)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L06 compound treatment 8.2644101E7 -1.71E7 -0.98 8.7812572E7 -1.54E7 -0.95 -1.3623 -0.9999 2069303 SPBio_001184 COC(=O)CCC(=O)O[C@H]1CCC2(C)C(CCC3C4CC5OC6(CCC(C)CO6)[C@@H](C)C5C4(C)[C@H](O)C(=O)C32)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L07 compound treatment 2.8215075E7 -7.16E7 -4.09 2.887812E7 -7.43E7 -4.58 -6.1307 -0.9984 3177465 SPBio_001185 CO[C@@H]1C[C@H](O[C@H]2CC[C@@]3(C)[C@H](CCC4C3CC[C@]5(C)[C@H]([C@H](C[C@]45O)OC(=O)C)C6=CC(=O)OC6)C2)OC(C)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L08 compound treatment 7.8495893E7 -2.13E7 -1.22 8.4042376E7 -1.91E7 -1.18 -1.6943 -0.9999 3054136 SPBio_001186 CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L09 compound treatment 7.8812734E7 -2.1E7 -1.2 8.9726079E7 -1.35E7 -0.83 -1.4337 -0.9839 1000807 SPBio_001187 CN1CCN(CC1)C(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L10 compound treatment 7.3241538E7 -2.65E7 -1.52 8.4252104E7 -1.89E7 -1.17 -1.8975 -0.9916 2060309 SPBio_001188 CC12CCC3C(CCC4(O)CC(O)CCC34/C=N/NC(=O)N)C2(O)CCC1C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L11 compound treatment 4.061473E7 -5.92E7 -3.38 4.3140997E7 -6.0E7 -3.7 -5.008 -0.999 3174220 SPBio_001189 CO[C@@H]1C[C@@H](C[C@H]2CC[C@H](C)[C@@H](O2)[C@@H](C)C(=O)O)O[C@]3(O[C@@](C)(C[C@H]3C)[C@H]4CC[C@](C)(O4)C5O[C@H](C[C@@H]5C)C6O[C@@](O)(CO)[C@H](C)C[C@@H]6C)[C@@H]1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L12 compound treatment 7.5356344E7 -2.44E7 -1.4 7.7902898E7 -2.53E7 -1.56 -2.0888 -0.9985 3079388 SPBio_001190 COc1ccc2CC[C@H]3C[C@H](O)CC[C@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L13 compound treatment 2.901112E7 -7.08E7 -4.04 2.9704261E7 -7.35E7 -4.53 -6.0626 -0.9984 2038 SPBio_001191 CCN(CC)C(=S)SSC(=S)N(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L14 compound treatment 7.5464333E7 -2.43E7 -1.39 8.0067437E7 -2.31E7 -1.42 -1.9901 -0.9999 967 SPBio_001192 C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)/C=C/C=C(\C)/C=C/C2=C(C)CCCC2(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L15 compound treatment 8.2600074E7 -1.72E7 -0.98 8.7693218E7 -1.55E7 -0.95 -1.3693 -0.9999 1589 SPBio_001193 CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L16 compound treatment 8.2600225E7 -1.72E7 -0.98 8.7681947E7 -1.55E7 -0.96 -1.3698 -0.9999 418 SPBio_001194 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L17 compound treatment 8.8499602E7 -1.13E7 -0.64 9.2963096E7 -1.02E7 -0.63 -0.9012 -0.9999 1214 SPBio_001195 CCOC(=O)Nc1c[n+](no1)N2CCOCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L18 compound treatment 8.9743883E7 -1.0E7 -0.57 8.8794906E7 -1.44E7 -0.89 -1.0326 -0.9777 1293 SPBio_001196 CC(=O)OCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L19 compound treatment 9.2118944E7 -7660000.0 -0.44 9.5260268E7 -7920000.0 -0.49 -0.6548 -0.9985 3480106 SPBio_001197 CC(C)(C(=O)O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L20 compound treatment 9.2722861E7 -7050000.0 -0.4 9.7934953E7 -5250000.0 -0.32 -0.5138 -0.9941 746 SPBio_001198 C(N(Cc1ccccc1)c2ccccc2)C3=NCCN3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L21 compound treatment 9.257749E7 -7200000.0 -0.41 9.9997177E7 -3190000.0 -0.2 -0.4298 -0.9427 3000787 SPBio_001199 [O-][N+](=O)c1ccc(cc1)c2ccc(/C=N/N3CC(=O)NC3=O)o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L22 compound treatment 3.2317261E7 -6.75E7 -3.86 3.2686137E7 -7.05E7 -4.35 -5.799 -0.9982 3177462 SPBio_001200 CCCCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(O)C[C@@]21C)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L23 mock treatment 9.4376281E7 -5400000.0 -0.31 9.2716268E7 -1.05E7 -0.65 -0.6744 -0.943 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 L24 mock treatment 1.08152241E8 8380000.0 0.48 1.01972783E8 -1210000.0 -0.07 0.2857 0.5898 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M01 mock treatment 1.10449118E8 1.07E7 0.61 1.13982195E8 1.08E7 0.67 0.902 0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M02 mock treatment 1.01162973E8 1390000.0 0.08 1.05298065E8 2120000.0 0.13 0.1482 0.9715 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M03 compound treatment 9.0897851E7 -8880000.0 -0.51 9.7990413E7 -5190000.0 -0.32 -0.5851 -0.9753 1018 SPBio_001201 COc1ccc2C[C@H]3[C@@H]4CCCC[C@@]4(CCN3C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M04 compound treatment 9.4328998E7 -5450000.0 -0.31 9.2840468E7 -1.03E7 -0.64 -0.6709 -0.9457 1696 SPBio_001202 CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M05 compound treatment 8.4192708E7 -1.56E7 -0.89 9.1536594E7 -1.16E7 -0.72 -1.1374 -0.9943 1164 SPBio_001203 CCN(CC)C(=O)N1CCN(C)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M06 compound treatment 8.1370642E7 -1.84E7 -1.05 8.8683178E7 -1.45E7 -0.89 -1.3758 -0.9967 1012497 SPBio_001204 NC(Cc1c[nH]c2ccccc12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M07 compound treatment 8.1913621E7 -1.79E7 -1.02 8.6683699E7 -1.65E7 -1.02 -1.441 -1.0 1378 SPBio_001205 NCCc1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M08 compound treatment 8.2104921E7 -1.77E7 -1.01 8.8298263E7 -1.49E7 -0.92 -1.3629 -0.9989 3055 SPBio_001206 NC(=N)NCCN1CCCCCCC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M09 compound treatment 7.6135832E7 -2.36E7 -1.35 8.6169334E7 -1.7E7 -1.05 -1.697 -0.9922 1462 SPBio_001207 CC1C(CCC(C)(C)N1C)OC(=O)C(O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M10 compound treatment 7.7779634E7 -2.2E7 -1.26 8.4123007E7 -1.91E7 -1.17 -1.7197 -0.9994 896 SPBio_001208 COc1ccccc1OCC(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M11 compound treatment 7.2536956E7 -2.72E7 -1.56 7.7696747E7 -2.55E7 -1.57 -2.2117 -1.0 1000135 SPBio_001209 CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M12 compound treatment 4.034429E7 -5.94E7 -3.4 4.0208535E7 -6.3E7 -3.88 -5.1467 -0.9978 1238 SPBio_001210 Oc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M13 compound treatment 7.2279868E7 -2.75E7 -1.57 7.4925589E7 -2.83E7 -1.74 -2.3429 -0.9987 2117626 SPBio_001211 Fc1ccc(cc1)C(CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34)c5ccc(F)cc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M14 compound treatment 4.0090736E7 -5.97E7 -3.41 4.2403792E7 -6.08E7 -3.75 -5.0613 -0.9989 1344 SPBio_001212 CCCC(=O)O[C@@]1(CCC2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@@]21C)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M15 compound treatment 8.3282499E7 -1.65E7 -0.94 8.7982344E7 -1.52E7 -0.94 -1.3291 -1.0 1115 SPBio_001213 C[C@@]12CCC3C(CCC4=C3CCC(=O)C4)C2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M16 compound treatment 2.9103084E7 -7.07E7 -4.04 3.0179376E7 -7.3E7 -4.5 -6.0381 -0.9985 3055280 SPBio_001214 CCCCCCc1ccc(O)cc1O.Nc1c2ccccc2nc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M17 compound treatment 8.8004409E7 -1.18E7 -0.67 9.084161E7 -1.23E7 -0.76 -1.0137 -0.9981 3173215 SPBio_001215 Cc1onc(c1C(=O)NC2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M18 compound treatment 9.1578013E7 -8200000.0 -0.47 9.2673165E7 -1.05E7 -0.65 -0.7894 -0.9873 1001518 SPBio_001216 CCC[C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCCC[C@@H]21)C(=O)O)C(=O)OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M19 compound treatment 9.1318214E7 -8460000.0 -0.48 9.1315512E7 -1.19E7 -0.73 -0.8591 -0.9798 952 SPBio_001217 CC(C)(S)[C@@H](N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M20 compound treatment 9.1279491E7 -8500000.0 -0.49 9.3551607E7 -9630000.0 -0.59 -0.7632 -0.995 732 SPBio_001218 Oc1cc(cc([N+](=O)[O-])c1O)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M21 compound treatment 4.612226E7 -5.37E7 -3.07 4.9063844E7 -5.41E7 -3.34 -4.5272 -0.9991 848 SPBio_001219 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M22 compound treatment 9.4788785E7 -4990000.0 -0.29 9.5746768E7 -7440000.0 -0.46 -0.5257 -0.9739 1402 SPBio_001220 CC[N+](C)(C)c1cccc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M23 mock treatment 9.4405471E7 -5370000.0 -0.31 9.486947E7 -8310000.0 -0.51 -0.5794 -0.97 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 M24 mock treatment 1.01633956E8 1860000.0 0.11 1.06387051E8 3200000.0 0.2 0.2147 0.9576 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N01 mock treatment 1.03140193E8 3360000.0 0.19 1.09813965E8 6630000.0 0.41 0.425 0.9408 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N02 mock treatment 9.8036858E7 -1740000.0 -0.1 1.03648536E8 466000.0 0.03 -0.05 -0.4833 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N03 compound treatment 8.5809472E7 -1.4E7 -0.8 9.4608873E7 -8570000.0 -0.53 -0.9382 -0.98 1331 SPBio_001221 CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N04 compound treatment 9.1412933E7 -8360000.0 -0.48 9.523479E7 -7950000.0 -0.49 -0.6844 -0.9999 451 SPBio_001222 Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N05 compound treatment 8.4492505E7 -1.53E7 -0.87 8.9235883E7 -1.39E7 -0.86 -1.2256 -1.0 1494 SPBio_001223 C1CN(CCN1)c2ccc3ccccc3n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N06 compound treatment 2.8045922E7 -7.17E7 -4.1 2.8672992E7 -7.45E7 -4.59 -6.1465 -0.9984 1454 SPBio_001224 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CCC6C5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N07 compound treatment 3.5170607E7 -6.46E7 -3.69 3.5480964E7 -6.77E7 -4.17 -5.5619 -0.9981 1313 SPBio_001225 Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N08 compound treatment 7.5704776E7 -2.41E7 -1.38 8.1478498E7 -2.17E7 -1.34 -1.9188 -0.9999 935 SPBio_001226 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N09 compound treatment 7.1733445E7 -2.8E7 -1.6 8.5601396E7 -1.76E7 -1.08 -1.8996 -0.9819 806 SPBio_001227 OC(=O)C1CCCNC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N10 compound treatment 6.9325689E7 -3.05E7 -1.74 7.6566389E7 -2.66E7 -1.64 -2.3907 -0.9996 1297 SPBio_001228 COc1cc(CC=C)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N11 compound treatment 6.8242238E7 -3.15E7 -1.8 7.4553148E7 -2.86E7 -1.76 -2.5223 -0.9999 1258 SPBio_001229 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCNCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N12 compound treatment 3.0719603E7 -6.91E7 -3.95 3.136973E7 -7.18E7 -4.43 -5.9209 -0.9984 945 SPBio_001230 C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N13 compound treatment 4.4811323E7 -5.5E7 -3.14 4.5707083E7 -5.75E7 -3.54 -4.7265 -0.9982 2555 SPBio_001231 CCOC(=O)NC1=C(C2CC2)C(=O)C(=C(C3CC3)C1=O)NC(=O)OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N14 compound treatment 3.3573529E7 -6.62E7 -3.78 3.3342751E7 -6.98E7 -4.31 -5.7196 -0.9979 694 SPBio_001232 C[C@H]1CC2C3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)C4(C)C=CC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N15 compound treatment 8.5063629E7 -1.47E7 -0.84 8.8533824E7 -1.46E7 -0.9 -1.2331 -0.9994 448 SPBio_001233 Clc1cccc(Cl)c1N=C2NCCN2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N16 compound treatment 8.2866139E7 -1.69E7 -0.97 8.7340731E7 -1.58E7 -0.98 -1.3739 -1.0 742 SPBio_001234 C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]3(C)C2[C@H](O)C[C@H]4/C(=C(/CCC=C(C)C)\C(=O)O)/[C@H](C[C@@]43C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N17 compound treatment 8.9883849E7 -9890000.0 -0.57 9.2895293E7 -1.03E7 -0.63 -0.8482 -0.9984 1204 SPBio_001235 CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)C(=O)N[C@]5(C)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C5=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N18 compound treatment 7.7040464E7 -2.27E7 -1.3 7.7189067E7 -2.6E7 -1.6 -2.0518 -0.9946 1261 SPBio_001236 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N19 compound treatment 8.86045E7 -1.12E7 -0.64 9.188235E7 -1.13E7 -0.7 -0.944 -0.9991 3173761 SPBio_001237 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N20 compound treatment 4.8958349E7 -5.08E7 -2.9 5.1259791E7 -5.19E7 -3.2 -4.3169 -0.9988 1136 SPBio_001238 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)COC(=O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N21 compound treatment 9.4023072E7 -5750000.0 -0.33 9.5786746E7 -7400000.0 -0.46 -0.5549 -0.9871 924 SPBio_001239 NC(=N)NC(=N)Nc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N22 compound treatment 8.5274391E7 -1.45E7 -0.83 8.3765616E7 -1.94E7 -1.2 -1.4324 -0.9839 859 SPBio_001240 CC(=O)O[C@@]1(CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)C3CC[C@@]21C)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N23 mock treatment 9.7044636E7 -2730000.0 -0.16 9.7807652E7 -5380000.0 -0.33 -0.3447 -0.941 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 N24 mock treatment 1.10392334E8 1.06E7 0.61 1.02447852E8 -735000.0 -0.05 0.397 0.6525 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O01 mock treatment 9.7987074E7 -1790000.0 -0.1 1.12151064E8 8970000.0 0.55 0.3186 0.5667 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O02 mock treatment 9.0617313E7 -9160000.0 -0.52 9.6726641E7 -6460000.0 -0.4 -0.6516 -0.9909 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O03 compound treatment 3.1452258E7 -6.83E7 -3.9 3.302505E7 -7.02E7 -4.32 -5.8192 -0.9987 3172851 SPBio_001241 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O04 compound treatment 7.4385923E7 -2.54E7 -1.45 8.2229132E7 -2.1E7 -1.29 -1.9394 -0.9983 52159 SPBio_001242 COc1ccc2[nH]cc(CCN)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O05 compound treatment 7.3755078E7 -2.6E7 -1.49 8.6345874E7 -1.68E7 -1.04 -1.7855 -0.9845 3059213 SPBio_001243 COc1ccc(C(=O)c2ccccc2O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O06 compound treatment 2.9560532E7 -7.02E7 -4.01 3.0193761E7 -7.3E7 -4.5 -6.019 -0.9984 1009556 SPBio_001244 Nc1c2ccccc2nc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O07 compound treatment 7.0748137E7 -2.9E7 -1.66 7.8511553E7 -2.47E7 -1.52 -2.2485 -0.9991 1112 SPBio_001245 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O08 compound treatment 2.7732718E7 -7.2E7 -4.12 2.8630153E7 -7.46E7 -4.6 -6.161 -0.9985 2060287 SPBio_001246 Cc1c(O)c(O)cc2c1CC=C3[C@@]2(C)CC[C@@]4(C)C5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O09 compound treatment 6.841154E7 -3.14E7 -1.79 7.9966466E7 -2.32E7 -1.43 -2.2795 -0.9938 3058535 SPBio_001247 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O10 compound treatment 7.1712195E7 -2.81E7 -1.6 7.9828718E7 -2.34E7 -1.44 -2.1521 -0.9985 3044526 SPBio_001248 NC(=N)N/N=C\c1c(Cl)cccc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O11 compound treatment 3.2834891E7 -6.69E7 -3.83 3.3085402E7 -7.01E7 -4.32 -5.7607 -0.9982 3177453 SPBio_001249 CC(=O)OCC(=O)[C@]12OC(C)(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]31C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O12 compound treatment 2.9149048E7 -7.06E7 -4.04 2.9900819E7 -7.33E7 -4.52 -6.0484 -0.9984 825 SPBio_001250 CC(Cc1ccc(O)c(O)c1)(NN)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O13 compound treatment 7.2981114E7 -2.68E7 -1.53 7.7128768E7 -2.61E7 -1.61 -2.2185 -0.9997 3045799 SPBio_001251 NC(=Nc1nc(CSCC/C(=N\S(=O)(=O)N)/N)cs1)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O14 compound treatment 8.4740202E7 -1.5E7 -0.86 8.4315153E7 -1.89E7 -1.16 -1.4301 -0.9889 3173079 SPBio_001252 CC1(C)N[C@@H](C(=O)N1C2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O15 compound treatment 7.8485205E7 -2.13E7 -1.22 8.7510001E7 -1.57E7 -0.97 -1.5436 -0.9935 1509 SPBio_001253 Cn1c(COC(=O)N)ncc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O16 compound treatment 8.1338617E7 -1.84E7 -1.05 8.5370371E7 -1.78E7 -1.1 -1.5215 -0.9998 2060386 SPBio_001254 CCN1C[C@]2(C)CC[C@H](OC)[C@@]34C2[C@H](O)[C@]5(OCO[C@]65C[C@H](OC)[C@H]7C[C@]4(O)C6[C@H]7O)C13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O17 compound treatment 8.3730885E7 -1.6E7 -0.92 9.2260487E7 -1.09E7 -0.67 -1.1245 -0.9885 1443 SPBio_001255 CN(C)CCOC(c1ccccc1)c2ccccc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O18 compound treatment 8.2259122E7 -1.75E7 -1.0 9.1718338E7 -1.15E7 -0.71 -1.2076 -0.9855 2857 SPBio_001256 O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O19 compound treatment 8.7761251E7 -1.2E7 -0.69 9.485621E7 -8330000.0 -0.51 -0.8485 -0.9897 719 SPBio_001257 CN(CC#C)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O20 compound treatment 7.4148786E7 -2.56E7 -1.46 8.7685845E7 -1.55E7 -0.96 -1.7112 -0.9786 3198424 SPBio_001258 CN(C)CCCN1C(=C(C)Sc2ccccc12)/C=C(\C=C)/C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O21 compound treatment 9.5706061E7 -4070000.0 -0.23 9.3410032E7 -9770000.0 -0.6 -0.5905 -0.9143 931 SPBio_001259 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O22 compound treatment 9.2449063E7 -7330000.0 -0.42 9.802248E7 -5160000.0 -0.32 -0.521 -0.9908 3059817 SPBio_001260 CCCCC(=O)N(Cc1ccc(cc1)c2ccccc2c3nn[nH]n3)[C@@H](C(C)C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O23 mock treatment 9.5536303E7 -4240000.0 -0.24 9.9025932E7 -4160000.0 -0.26 -0.3525 -0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 O24 mock treatment 1.08649082E8 8870000.0 0.51 1.13765907E8 1.06E7 0.65 0.8199 0.9922 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P01 mock treatment 1.02150949E8 2370000.0 0.14 1.11203734E8 8020000.0 0.49 0.4456 0.8691 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P02 mock treatment 9.5099645E7 -4680000.0 -0.27 1.09401762E8 6220000.0 0.38 0.0821 0.1756 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P03 compound treatment 8.8178348E7 -1.16E7 -0.66 1.04738709E8 1560000.0 0.1 -0.4009 -0.5986 1213 SPBio_001261 CNCCc1ccccn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P04 compound treatment 7.7057583E7 -2.27E7 -1.3 8.6041951E7 -1.71E7 -1.06 -1.6653 -0.9948 3198429 SPBio_001262 CC(=O)O[C@@]1(CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P05 compound treatment 8.97779E7 -1.0E7 -0.57 9.8671439E7 -4510000.0 -0.28 -0.6007 -0.9452 749 SPBio_001263 NC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P06 compound treatment 8.2520866E7 -1.73E7 -0.99 8.5591662E7 -1.76E7 -1.08 -1.4641 -0.9989 1062 SPBio_001264 COc1ccccc1OCC(O)COC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P07 compound treatment 8.1686054E7 -1.81E7 -1.03 8.5014112E7 -1.82E7 -1.12 -1.523 -0.9992 1119 SPBio_001265 CSCCC(NC=O)C(=O)NC(Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P08 compound treatment 7.8307953E7 -2.15E7 -1.23 9.0422602E7 -1.28E7 -0.79 -1.4238 -0.9769 842 SPBio_001266 Cn1cc[nH]c1=S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P09 compound treatment 2.838913E7 -7.14E7 -4.08 2.965285E7 -7.35E7 -4.53 -6.0899 -0.9986 449 SPBio_001267 CC1=CC(=O)c2ccccc2C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P10 compound treatment 3.2802011E7 -6.7E7 -3.83 3.3526357E7 -6.97E7 -4.29 -5.7428 -0.9984 1234 SPBio_001268 C[C@H]1CC2C3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P11 compound treatment 8.1383297E7 -1.84E7 -1.05 8.0572019E7 -2.26E7 -1.39 -1.7289 -0.9903 1464728 SPBio_001269 Cn1c(=O)[nH]c2nc[nH]c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P12 compound treatment 5.1343228E7 -4.84E7 -2.77 5.9971489E7 -4.32E7 -2.66 -3.8408 -0.9998 3045140 SPBio_001270 CC(C)[N+]1(C)C2CC[C@@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P13 compound treatment 8.0152641E7 -1.96E7 -1.12 8.9549437E7 -1.36E7 -0.84 -1.3873 -0.9899 925 SPBio_001271 C[C@@H]([C@H](O)c1ccccc1)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P14 compound treatment 7.6837049E7 -2.29E7 -1.31 8.5833793E7 -1.73E7 -1.07 -1.6832 -0.9949 1321 SPBio_001272 Cc1cc(=O)[nH]c(=S)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P15 compound treatment 7.7765614E7 -2.2E7 -1.26 8.654685E7 -1.66E7 -1.03 -1.6146 -0.9949 1492782 SPBio_001273 OCNC(=O)c1cccnc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P16 compound treatment 7.7987715E7 -2.18E7 -1.25 8.4278472E7 -1.89E7 -1.17 -1.7045 -0.9995 884 SPBio_001274 CN(C)CCC(c1ccccc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P17 compound treatment 8.7407224E7 -1.24E7 -0.71 9.9446892E7 -3740000.0 -0.23 -0.6627 -0.8914 771 SPBio_001275 CN1CCC(=C2c3ccsc3C(=O)Cc4ccccc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P18 compound treatment 7.9541196E7 -2.02E7 -1.16 9.1469841E7 -1.17E7 -0.72 -1.3283 -0.9743 822 SPBio_001276 CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P19 compound treatment 6.4847849E7 -3.49E7 -2.0 7.3592531E7 -2.96E7 -1.82 -2.7013 -0.999 1130 SPBio_001277 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P20 compound treatment 4.1060917E7 -5.87E7 -3.36 5.3828847E7 -4.94E7 -3.04 -4.5241 -0.9988 1511 SPBio_001278 Oc1ccc(cc1)C2(OC(=O)c3ccccc32)c4ccc(O)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P21 compound treatment 8.8352572E7 -1.14E7 -0.65 1.03554469E8 371000.0 0.02 -0.4455 -0.6819 752 SPBio_001279 CC1CCc2cc(F)cc3c(=O)c(cn1c23)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P22 compound treatment 9.7918552E7 -1860000.0 -0.11 1.06100604E8 2920000.0 0.18 0.0521 0.2494 1208 SPBio_001280 CNC[C@H](O)c1cccc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P23 mock treatment 1.0452993E8 4750000.0 0.27 1.10184217E8 7000000.0 0.43 0.4973 0.9751 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2161 P24 mock treatment 1.11811097E8 1.2E7 0.69 1.20156025E8 1.7E7 1.05 1.2262 0.9793 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A01 mock treatment 1.24468656E8 2.39E7 1.37 1.29834324E8 2.71E7 1.67 2.1454 0.9951 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A02 mock treatment 1.13276012E8 1.27E7 0.73 1.18508967E8 1.57E7 0.97 1.1994 0.9898 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A03 compound treatment 1.0908903E8 8510000.0 0.49 1.15165017E8 1.24E7 0.76 0.8845 0.9762 1126 SPBio_001281 O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A04 compound treatment 1.21818203E8 2.12E7 1.21 1.2647873E8 2.37E7 1.46 1.892 0.9957 1065 SPBio_001282 CN1C(CC(O)c2ccccc2)CCCC1CC(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A05 compound treatment 1.01090554E8 516000.0 0.03 1.14838865E8 1.21E7 0.74 0.547 0.7345 968 SPBio_001283 CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A06 compound treatment 1.02702658E8 2130000.0 0.12 1.02223549E8 -544000.0 -0.03 0.0623 0.4939 802 SPBio_001284 Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A07 compound treatment 7.6824692E7 -2.38E7 -1.36 8.2782107E7 -2.0E7 -1.23 -1.8309 -0.9988 976 SPBio_001285 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A08 compound treatment 1.00981821E8 407000.0 0.02 1.06483996E8 3720000.0 0.23 0.1785 0.7749 1284 SPBio_001286 OC(=O)CN(CC(=O)O)Cc1cc2c(c3ccccc3C(=O)O)c4cc(CN(CC(=O)O)CC(=O)O)c(=O)cc4oc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A09 compound treatment 9.4712026E7 -5860000.0 -0.34 1.01644125E8 -1120000.0 -0.07 -0.2859 -0.8355 992 SPBio_001287 CC[C@H]1[C@@H](Cc2cncn2C)COC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A10 compound treatment 9.8159893E7 -2420000.0 -0.14 9.9963048E7 -2800000.0 -0.17 -0.2198 -0.9938 686 SPBio_001288 C(Nc1ncnc2[nH]cnc12)c3ccco3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A11 compound treatment 9.5845904E7 -4730000.0 -0.27 1.00963378E8 -1800000.0 -0.11 -0.2697 -0.9229 1428 SPBio_001289 CC(C)NCC(O)COc1cccc2[nH]ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A12 compound treatment 1.0342567E8 2850000.0 0.16 1.02566231E8 -201000.0 -0.01 0.1065 0.6515 3058615 SPBio_001290 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A13 compound treatment 9.592008E7 -4650000.0 -0.27 1.02026333E8 -741000.0 -0.05 -0.2204 -0.8165 3173725 SPBio_001291 CCN1CCN(C(=O)NC(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4)C(=O)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A14 compound treatment 9.9582334E7 -993000.0 -0.06 1.03716101E8 949000.0 0.06 0.0013 0.0154 2069337 SPBio_001292 COC(=O)C(C)c1ccc(cc1)C(=O)c2cccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A15 compound treatment 9.5540851E7 -5030000.0 -0.29 1.01734806E8 -1030000.0 -0.06 -0.2484 -0.8431 347 SPBio_001293 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A16 compound treatment 9.4881622E7 -5690000.0 -0.33 1.02802297E8 35200.0 0.0 -0.2285 -0.7024 1606 SPBio_001294 NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A17 compound treatment 1.00852599E8 278000.0 0.02 1.03547871E8 781000.0 0.05 0.0453 0.8929 1000106 SPBio_001295 O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A18 compound treatment 1.14136079E8 1.36E7 0.78 1.16867972E8 1.41E7 0.87 1.1627 0.9984 2060333 SPBio_001296 COc1ccc(/C=C/c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A19 compound treatment 5.2432879E7 -4.81E7 -2.75 5.2322619E7 -5.04E7 -3.11 -4.1443 -0.9981 349 SPBio_001297 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A20 compound treatment 1.0807011E8 7500000.0 0.43 1.07048412E8 4280000.0 0.26 0.4895 0.9729 3054675 SPBio_001298 CC(C)CCCC(C)C1CCC2/C(=C/C=C\3/C[C@@H](O)CCC3=C)/CCCC12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A21 compound treatment 3.8541907E7 -6.2E7 -3.55 4.0749738E7 -6.2E7 -3.82 -5.2101 -0.9993 1289 SPBio_001299 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)C=C[C@]34C)C2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A22 compound treatment 1.05484995E8 4910000.0 0.28 1.04351371E8 1580000.0 0.1 0.2675 0.9002 2060331 SPBio_001300 CC1=CCC(=C)[C@H]2CC(C)(C)[C@@H]2CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A23 mock treatment 1.13665928E8 1.31E7 0.75 1.18029082E8 1.53E7 0.94 1.1943 0.9936 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 A24 mock treatment 1.28355736E8 2.78E7 1.59 1.26024828E8 2.33E7 1.43 2.1364 0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B01 mock treatment 1.26862824E8 2.63E7 1.5 1.27992394E8 2.52E7 1.55 2.1619 0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B02 mock treatment 1.00137574E8 -437000.0 -0.02 1.0537551E8 2610000.0 0.16 0.096 0.5901 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B03 compound treatment 2.9029557E7 -7.15E7 -4.09 3.1500907E7 -7.13E7 -4.39 -5.9977 -0.9994 1531 SPBio_001301 O=c1n([se]c2ccccc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B04 compound treatment 8.8794228E7 -1.18E7 -0.67 9.799843E7 -4770000.0 -0.29 -0.6839 -0.931 1339 SPBio_001302 CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B05 compound treatment 5.1367519E7 -4.92E7 -2.81 4.9323581E7 -5.34E7 -3.29 -4.3181 -0.9969 1168 SPBio_001303 CC12CCC3C(CCc4cc(OCc5ccccc5)ccc34)C2C[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B06 compound treatment 9.9139887E7 -1440000.0 -0.08 1.01545734E8 -1220000.0 -0.08 -0.1112 -0.9991 691 SPBio_001304 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2C1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B07 compound treatment 3.4492759E7 -6.61E7 -3.78 4.3617791E7 -5.91E7 -3.65 -5.2487 -0.9998 2060367 SPBio_001305 CS(=O)(=O)CCCCN=C=S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B08 compound treatment 8.7648565E7 -1.29E7 -0.74 9.2134747E7 -1.06E7 -0.66 -0.9858 -0.9982 3173981 SPBio_001306 CCOC(=O)OC(C)OC(=O)C1N2C(SC1(C)C)C(NC(=O)[C@H](N)c3ccccc3)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B09 compound treatment 8.5737483E7 -1.48E7 -0.85 9.5216241E7 -7550000.0 -0.47 -0.9287 -0.9601 902 SPBio_001307 OC(=O)c1cc2cc(Cc3cccnc3)ccc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B10 compound treatment 9.1379258E7 -9200000.0 -0.53 9.3862291E7 -8900000.0 -0.55 -0.7598 -0.9998 917 SPBio_001308 NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B11 compound treatment 2.9552023E7 -7.1E7 -4.06 3.1465761E7 -7.13E7 -4.4 -5.9781 -0.9992 1045 SPBio_001309 C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B12 compound treatment 7.5562556E7 -2.5E7 -1.43 7.6253603E7 -2.65E7 -1.63 -2.1665 -0.9978 841 SPBio_001310 C/C(=C(/CCOP(=O)(O)O)\SC(=O)c1ccccc1)/N(Cc2cnc(C)nc2N)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B13 compound treatment 9.40417E7 -6530000.0 -0.37 9.4771544E7 -8000000.0 -0.49 -0.6125 -0.9906 1258696 SPBio_001311 Cc1c(Cl)cccc1Nc2ccccc2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B14 compound treatment 8.842677E7 -1.21E7 -0.69 9.4012872E7 -8750000.0 -0.54 -0.8725 -0.9922 1082 SPBio_001312 CN(Cc1cc(Br)cc(Br)c1N)C2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B15 compound treatment 1.01473313E8 898000.0 0.05 9.7029736E7 -5740000.0 -0.35 -0.2138 -0.5982 1196 SPBio_001313 CCCOc1ccccc1c2nc3[nH]nnc3c(=O)[nH]2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B16 compound treatment 9.480307E7 -5770000.0 -0.33 9.8065536E7 -4700000.0 -0.29 -0.4382 -0.9979 955 SPBio_001314 CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B17 compound treatment 9.5262874E7 -5310000.0 -0.3 9.5937164E7 -6830000.0 -0.42 -0.5124 -0.9871 1076 SPBio_001315 Cc1cccc(C)c1NC2=NCCCS2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B18 compound treatment 9.0067248E7 -1.05E7 -0.6 9.3069239E7 -9700000.0 -0.6 -0.8473 -1.0 1000338 SPBio_001316 NC[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B19 compound treatment 9.6642495E7 -3930000.0 -0.22 9.8538154E7 -4230000.0 -0.26 -0.3432 -0.9973 196 SPBio_001317 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B20 compound treatment 1.06722045E8 6150000.0 0.35 1.11063495E8 8300000.0 0.51 0.61 0.9832 2359 SPBio_001318 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@@H]32)n1c5ccccc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B21 compound treatment 9.1914687E7 -8660000.0 -0.49 1.07186897E8 4420000.0 0.27 -0.1573 -0.2785 1000121 SPBio_001319 C/C(=C\CO)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B22 compound treatment 4.196308E7 -5.86E7 -3.35 4.9223164E7 -5.35E7 -3.3 -4.7025 -1.0 755 SPBio_001320 CC(CN(C)C)CN1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B23 mock treatment 1.01757173E8 1180000.0 0.07 1.03509279E8 742000.0 0.05 0.0801 0.982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 B24 mock treatment 1.14437113E8 1.39E7 0.79 1.18161937E8 1.54E7 0.95 1.2312 0.996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C01 mock treatment 1.04990972E8 4420000.0 0.25 1.05965776E8 3200000.0 0.2 0.3179 0.9925 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C02 mock treatment 9.2021386E7 -8550000.0 -0.49 9.5546881E7 -7220000.0 -0.45 -0.6604 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C03 compound treatment 3.4565392E7 -6.6E7 -3.77 3.581734E7 -6.69E7 -4.13 -5.5858 -0.999 1455 SPBio_001321 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C04 compound treatment 8.370715E7 -1.69E7 -0.96 8.925524E7 -1.35E7 -0.83 -1.2706 -0.9973 1031375 SPBio_001322 NC(CCCNC(=O)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C05 compound treatment 9.3517026E7 -7060000.0 -0.4 9.1403543E7 -1.14E7 -0.7 -0.7805 -0.9656 1273 SPBio_001323 C[C@@]12CC(=O)C3C(CCC4=CC(=O)C=C[C@]34C)C2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C06 compound treatment 9.2345334E7 -8230000.0 -0.47 9.2845986E7 -9920000.0 -0.61 -0.765 -0.9916 3054270 SPBio_001324 COC(=O)[C@@H]1C(O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C07 compound treatment 9.3705694E7 -6870000.0 -0.39 9.2793965E7 -9970000.0 -0.61 -0.7123 -0.9765 962 SPBio_001325 CCC1(C(=O)NCNC1=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C08 compound treatment 7.3224118E7 -2.74E7 -1.56 6.8748234E7 -3.4E7 -2.1 -2.5881 -0.9895 2060265 SPBio_001326 COC(=O)CCC(C)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C09 compound treatment 8.6100073E7 -1.45E7 -0.83 8.4334947E7 -1.84E7 -1.14 -1.3884 -0.9878 722 SPBio_001327 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C10 compound treatment 9.0761059E7 -9810000.0 -0.56 9.2822122E7 -9940000.0 -0.61 -0.8301 -0.999 2060267 SPBio_001328 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C11 compound treatment 9.4808387E7 -5770000.0 -0.33 9.7979091E7 -4790000.0 -0.3 -0.4417 -0.9985 2431 SPBio_001329 CCN(CC)CCNC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C12 compound treatment 9.1652015E7 -8920000.0 -0.51 9.1173847E7 -1.16E7 -0.71 -0.8659 -0.9863 3177457 SPBio_001330 CC(CCC(=O)O)[C@H]1CCC2C3C(CC(=O)[C@]12C)[C@@]4(C)CCC(=O)C[C@H]4CC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C13 compound treatment 9.4891699E7 -5680000.0 -0.32 9.3579812E7 -9190000.0 -0.57 -0.6301 -0.9652 779 SPBio_001331 CCN(CC)CCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C14 compound treatment 2.8444136E7 -7.21E7 -4.12 3.0150399E7 -7.26E7 -4.48 -6.0802 -0.9992 3174369 SPBio_001332 C[C@H]1OC(C[C@H](O)C1O)O[C@@H]2[C@@H](C)OC(C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6C5CC[C@]7(C)[C@H]([C@@H](O)C[C@]67O)C8=CC(=O)OC8)C4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C15 compound treatment 3.4310882E7 -6.63E7 -3.79 4.4183245E7 -5.86E7 -3.61 -5.2314 -0.9997 1041 SPBio_001333 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C16 compound treatment 8.5147211E7 -1.54E7 -0.88 7.3311485E7 -2.95E7 -1.82 -1.9074 -0.945 2880 SPBio_001334 N[C@@H](CCC(=O)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C17 compound treatment 8.1471552E7 -1.91E7 -1.09 6.7893724E7 -3.49E7 -2.15 -2.2921 -0.9507 1057 SPBio_001335 OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C18 compound treatment 8.723578E7 -1.33E7 -0.76 8.7008853E7 -1.58E7 -0.97 -1.2259 -0.9928 2060276 SPBio_001336 C[C@@H]1C(=O)OC2[C@H](O)C34[C@@H]5OC(=O)[C@@]4(O[C@@H]6OC(=O)[C@H](O)[C@@]63[C@@H]([C@H]5O)C(C)(C)C)[C@@]12O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C19 compound treatment 9.7133202E7 -3440000.0 -0.2 1.06198068E8 3430000.0 0.21 0.0105 0.0362 1000117 SPBio_001337 CC(=O)[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C20 compound treatment 8.9733375E7 -1.08E7 -0.62 1.04548886E8 1780000.0 0.11 -0.3605 -0.5728 1275107 SPBio_001338 C1Cc2c(CN1)[nH]c3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C21 compound treatment 8.7087592E7 -1.35E7 -0.77 9.9242468E7 -3520000.0 -0.22 -0.6987 -0.8724 1397 SPBio_001339 CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C22 compound treatment 9.6719581E7 -3860000.0 -0.22 9.9985776E7 -2780000.0 -0.17 -0.277 -0.9923 2060253 SPBio_001340 NC(CC(=O)c1ccccc1N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C23 mock treatment 9.4843505E7 -5730000.0 -0.33 1.0732024E8 4550000.0 0.28 -0.0332 -0.0769 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 C24 mock treatment 1.11506692E8 1.09E7 0.62 1.17625354E8 1.49E7 0.92 1.0894 0.9826 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D01 mock treatment 9.9074222E7 -1500000.0 -0.09 1.05473654E8 2710000.0 0.17 0.0573 0.3056 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D02 mock treatment 9.3099505E7 -7480000.0 -0.43 9.0564042E7 -1.22E7 -0.75 -0.834 -0.9641 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D03 compound treatment 8.0552514E7 -2.0E7 -1.14 8.0957443E7 -2.18E7 -1.34 -1.7598 -0.9968 1205 SPBio_001341 CC(=CCC1=C(O)C(=O)c2ccccc2C1=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D04 compound treatment 1.04792519E8 4220000.0 0.24 1.01997826E8 -769000.0 -0.05 0.1369 0.5573 1385 SPBio_001342 C(/C=C/N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D05 compound treatment 2.7656036E7 -7.29E7 -4.17 2.8823125E7 -7.39E7 -4.56 -6.1699 -0.999 1277 SPBio_001343 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(=O)C)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)C(CCC7C6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D06 compound treatment 9.5136658E7 -5440000.0 -0.31 9.7832696E7 -4930000.0 -0.3 -0.4349 -0.9999 1442 SPBio_001344 CC(=O)NC1SCCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D07 compound treatment 3.2178641E7 -6.84E7 -3.91 3.4913283E7 -6.79E7 -4.18 -5.7217 -0.9994 3172730 SPBio_001345 OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D08 compound treatment 3.4412751E7 -6.62E7 -3.78 3.8783921E7 -6.4E7 -3.94 -5.4627 -0.9998 1054 SPBio_001346 CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D09 compound treatment 9.1768611E7 -8810000.0 -0.5 9.450669E7 -8260000.0 -0.51 -0.7159 -1.0 1009973 SPBio_001347 OC(C(O)C(O)C(=O)O)C(O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D10 compound treatment 5.1520582E7 -4.91E7 -2.8 4.7669597E7 -5.51E7 -3.4 -4.384 -0.9955 716 SPBio_001348 CN(C)CCC=C1c2ccccc2C=Cc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D11 compound treatment 9.2191314E7 -8380000.0 -0.48 9.2189763E7 -1.06E7 -0.65 -0.7998 -0.9885 1036 SPBio_001349 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D12 compound treatment 6.2209443E7 -3.84E7 -2.19 6.3329571E7 -3.94E7 -2.43 -3.2694 -0.9987 1063 SPBio_001350 CC(CNCCc1ccc(O)c(O)c1)Cc2cccc(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D13 compound treatment 9.1923356E7 -8650000.0 -0.49 9.5476058E7 -7290000.0 -0.45 -0.6674 -0.9989 1608 SPBio_001351 NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D14 compound treatment 8.8124573E7 -1.25E7 -0.71 8.8005614E7 -1.48E7 -0.91 -1.1466 -0.9926 1507 SPBio_001352 CC(N)CCCC(C)(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D15 compound treatment 6.1604701E7 -3.9E7 -2.23 6.802802E7 -3.47E7 -2.14 -3.0891 -0.9998 769 SPBio_001353 CCCCOc1ccc(CC(=O)NO)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D16 compound treatment 8.9203166E7 -1.14E7 -0.65 9.5887432E7 -6880000.0 -0.42 -0.7594 -0.9786 766 SPBio_001354 CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D17 compound treatment 8.851748E7 -1.21E7 -0.69 8.9390925E7 -1.34E7 -0.82 -1.0703 -0.996 717 SPBio_001355 OC(=O)c1ccccc1OP(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D18 compound treatment 8.5267999E7 -1.53E7 -0.87 8.8278119E7 -1.45E7 -0.89 -1.2501 -0.9999 1348 SPBio_001356 Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D19 compound treatment 9.0898109E7 -9680000.0 -0.55 8.951876E7 -1.32E7 -0.82 -0.9685 -0.982 1117 SPBio_001357 Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cnc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D20 compound treatment 2.7193357E7 -7.34E7 -4.19 2.8345914E7 -7.44E7 -4.59 -6.2094 -0.999 1158 SPBio_001358 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D21 compound treatment 1.01519378E8 944000.0 0.05 1.03201996E8 435000.0 0.03 0.0571 0.9478 3079211 SPBio_001359 COC(=O)[C@]1(C)CCC[C@@]2(C)C1CC(=O)c3cc(ccc32)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D22 compound treatment 3.6439611E7 -6.41E7 -3.67 3.6593385E7 -6.62E7 -4.08 -5.4762 -0.9986 3046112 SPBio_001360 CC1(C)O[C@@H]2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)[C@@]2(O1)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D23 mock treatment 9.5469442E7 -5110000.0 -0.29 9.8892615E7 -3870000.0 -0.24 -0.3752 -0.9951 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 D24 mock treatment 9.8339823E7 -2240000.0 -0.13 1.13018671E8 1.03E7 0.63 0.3565 0.553 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E01 mock treatment 9.7749432E7 -2830000.0 -0.16 1.01531572E8 -1240000.0 -0.08 -0.168 -0.9412 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E02 mock treatment 9.9120614E7 -1450000.0 -0.08 9.4420021E7 -8350000.0 -0.51 -0.4226 -0.8108 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E03 compound treatment 1.01303224E8 728000.0 0.04 1.06350776E8 3580000.0 0.22 0.1856 0.8258 351 SPBio_001361 CC(C)NCC(O)COc1cccc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E04 compound treatment 9.56706E7 -4900000.0 -0.28 9.9460854E7 -3310000.0 -0.2 -0.3423 -0.9877 2069275 SPBio_001362 CC1(C)[C@H](CC[C@@]2(C)C1CC[C@@]3(C)C4CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC(=O)C32)C(=O)O)O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(=O)O)[C@H](O)[C@H]6O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E05 compound treatment 9.3173325E7 -7400000.0 -0.42 9.8081602E7 -4690000.0 -0.29 -0.5033 -0.9827 912 SPBio_001363 CCCc1cc(=O)[nH]c(=S)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E06 compound treatment 9.3002945E7 -7570000.0 -0.43 9.8365095E7 -4400000.0 -0.27 -0.4979 -0.9747 43 SPBio_001364 Fc1ccc(cc1)C(N2CCN(C/C=C/c3ccccc3)CC2)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E07 compound treatment 9.3485224E7 -7090000.0 -0.41 9.4702077E7 -8060000.0 -0.5 -0.638 -0.9948 1000118 SPBio_001365 CN[C@@H](C)[C@@H](O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E08 compound treatment 8.5952591E7 -1.46E7 -0.84 9.2414867E7 -1.04E7 -0.64 -1.0422 -0.9911 936 SPBio_001366 OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E09 compound treatment 9.2017322E7 -8560000.0 -0.49 9.7262008E7 -5510000.0 -0.34 -0.5858 -0.9841 3173593 SPBio_001367 CN1CCCN=C1/C=C/c2cccs2.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E10 compound treatment 8.4699859E7 -1.59E7 -0.91 9.13509E7 -1.14E7 -0.7 -1.1392 -0.9921 837 SPBio_001368 CCOc1ccc2NC(C)(C)C=C(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E11 compound treatment 9.1449376E7 -9130000.0 -0.52 9.4502951E7 -8260000.0 -0.51 -0.729 -0.9999 889 SPBio_001369 NC(=O)c1cnccn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E12 compound treatment 8.4559453E7 -1.6E7 -0.92 9.1045844E7 -1.17E7 -0.72 -1.1581 -0.9931 852 SPBio_001370 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E13 compound treatment 9.0331582E7 -1.02E7 -0.59 9.3649376E7 -9120000.0 -0.56 -0.8114 -0.9998 830 SPBio_001371 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E14 compound treatment 8.8854057E7 -1.17E7 -0.67 9.3895248E7 -8870000.0 -0.55 -0.8604 -0.9949 764 SPBio_001372 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)n3c(=O)[nH]c4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E15 compound treatment 2.8753743E7 -7.18E7 -4.1 3.0531398E7 -7.22E7 -4.45 -6.0511 -0.9992 3174105 SPBio_001373 CN(C)c1ccc2[n+](C)c(/C=C/c3cc(C)n(c3C)c4ccccc4)ccc2c1.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E16 compound treatment 9.0034816E7 -1.05E7 -0.6 9.3829935E7 -8940000.0 -0.55 -0.8155 -0.999 805 SPBio_001374 CCc1cccc2c3CCOC(CC)(CC(=O)O)c3[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E17 compound treatment 9.4512379E7 -6060000.0 -0.35 9.5387596E7 -7380000.0 -0.45 -0.5667 -0.991 792 SPBio_001375 COc1ccc2nccc([C@@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E18 compound treatment 9.4072482E7 -6500000.0 -0.37 9.4839072E7 -7930000.0 -0.49 -0.6083 -0.9909 1033 SPBio_001376 CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E19 compound treatment 9.6217204E7 -4360000.0 -0.25 9.4557779E7 -8210000.0 -0.51 -0.5339 -0.9467 836 SPBio_001377 CNC(C)C(O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E20 compound treatment 9.4329547E7 -6250000.0 -0.36 9.5111986E7 -7660000.0 -0.47 -0.5861 -0.9905 699 SPBio_001378 OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E21 compound treatment 9.1819703E7 -8760000.0 -0.5 9.4747731E7 -8020000.0 -0.49 -0.7034 -1.0 711 SPBio_001379 Oc1cccc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E22 compound treatment 7.0449775E7 -3.01E7 -1.72 6.9047106E7 -3.37E7 -2.08 -2.6872 -0.9956 1172 SPBio_001380 CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E23 mock treatment 9.2964544E7 -7610000.0 -0.43 9.8714479E7 -4050000.0 -0.25 -0.4842 -0.9653 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 E24 mock treatment 9.9880346E7 -695000.0 -0.04 1.05820042E8 3050000.0 0.19 0.105 0.5459 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F01 mock treatment 1.04005965E8 3430000.0 0.2 9.9284621E7 -3480000.0 -0.21 -0.0131 -0.0452 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F02 mock treatment 1.02762171E8 2190000.0 0.13 1.04053344E8 1290000.0 0.08 0.1445 0.9759 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F03 compound treatment 9.6349264E7 -4230000.0 -0.24 9.3412207E7 -9350000.0 -0.58 -0.5785 -0.9254 3173633 SPBio_001381 CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(N)c3ccccc3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F04 compound treatment 9.4505017E7 -6070000.0 -0.35 9.87667E7 -4000000.0 -0.25 -0.4197 -0.986 1298 SPBio_001382 CS(=O)(=O)Nc1ccc(cc1Oc2ccccc2)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F05 compound treatment 9.4084851E7 -6490000.0 -0.37 9.5590654E7 -7180000.0 -0.44 -0.5751 -0.9962 1067 SPBio_001383 CO[C@]1(NC(=O)CSCC#N)C2SCC(=C(N2C1=O)C(=O)O)CSc3nnnn3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F06 compound treatment 9.0176584E7 -1.04E7 -0.59 9.0941995E7 -1.18E7 -0.73 -0.9357 -0.9949 3045662 SPBio_001384 CC(N)C(O)c1cccc(O)c1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F07 compound treatment 9.2517937E7 -8060000.0 -0.46 9.8058118E7 -4710000.0 -0.29 -0.5309 -0.9753 3264 SPBio_001385 Cn1nnnc1SCC2=C(N3C(SC2)C(NC(=O)C(OC=O)c4ccccc4)C3=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F08 compound treatment 9.1977876E7 -8600000.0 -0.49 9.5401045E7 -7370000.0 -0.45 -0.6685 -0.9992 3069629 SPBio_001386 CC(=O)/N=c/1\sc(nn1C)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F09 compound treatment 8.8030929E7 -1.25E7 -0.72 9.4831557E7 -7940000.0 -0.49 -0.8528 -0.9826 1323 SPBio_001387 CC1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F10 compound treatment 2.6899871E7 -7.37E7 -4.21 2.7998513E7 -7.48E7 -4.61 -6.2364 -0.999 1286 SPBio_001388 Cc1cc(ccc1OCCOCC[N+](C)(C)Cc2ccccc2)C(C)(C)CC(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F11 compound treatment 8.9844253E7 -1.07E7 -0.61 9.2263792E7 -1.05E7 -0.65 -0.8915 -0.9996 1129 SPBio_001389 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F12 compound treatment 8.6095273E7 -1.45E7 -0.83 9.0626919E7 -1.21E7 -0.75 -1.1143 -0.9987 1535 SPBio_001390 COc1ccc(OC)c(c1)C(O)CNC(=O)CN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F13 compound treatment 8.6071394E7 -1.45E7 -0.83 9.0607296E7 -1.22E7 -0.75 -1.1161 -0.9987 2294 SPBio_001391 CC(=O)NC(C(=O)O)C(C)(C)SN=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F14 compound treatment 8.945634E7 -1.11E7 -0.64 9.4673557E7 -8090000.0 -0.5 -0.8021 -0.9928 1055 SPBio_001392 CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F15 compound treatment 8.9885334E7 -1.07E7 -0.61 9.2404288E7 -1.04E7 -0.64 -0.8837 -0.9998 366 SPBio_001393 OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F16 compound treatment 8.5343785E7 -1.52E7 -0.87 8.5627081E7 -1.71E7 -1.06 -1.3626 -0.9954 1163 SPBio_001394 Oc1ccc2C[C@H]3N(CC4CC4)CCC5([C@H]6Oc1c25)[C@@]3(O)CCC6=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F17 compound treatment 8.9812691E7 -1.08E7 -0.62 9.2168635E7 -1.06E7 -0.65 -0.8969 -0.9995 1591 SPBio_001395 CC(C)C[C@@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F18 compound treatment 9.0242446E7 -1.03E7 -0.59 9.2097542E7 -1.07E7 -0.66 -0.8826 -0.9986 1386 SPBio_001396 CN1CC(c2ccccc2)c3cccc(N)c3C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F19 compound treatment 9.2678521E7 -7900000.0 -0.45 9.5507411E7 -7260000.0 -0.45 -0.6355 -1.0 348755 SPBio_001397 OC(=O)c1cc2cc(F)ccc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F20 compound treatment 9.1744254E7 -8830000.0 -0.5 9.7579044E7 -5190000.0 -0.32 -0.583 -0.9758 1436 SPBio_001398 CCCNC(C)C(=O)Nc1ccccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F21 compound treatment 9.2497171E7 -8080000.0 -0.46 9.6152883E7 -6610000.0 -0.41 -0.6147 -0.9981 873168 SPBio_001399 OC(=O)c1cc(O)c2ccc(Cl)cc2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F22 compound treatment 8.5673121E7 -1.49E7 -0.85 8.9681202E7 -1.31E7 -0.81 -1.1726 -0.9996 3480197 SPBio_001400 CCC(NC(C)C)C(O)c1ccc(O)c2[nH]c(=O)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F23 mock treatment 9.0237082E7 -1.03E7 -0.59 9.9683985E7 -3080000.0 -0.19 -0.5522 -0.8897 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 F24 mock treatment 1.01950183E8 1380000.0 0.08 1.03043442E8 276000.0 0.02 0.0676 0.8409 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G01 mock treatment 9.3250561E7 -7320000.0 -0.42 9.8015627E7 -4750000.0 -0.29 -0.5031 -0.9847 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G02 mock treatment 9.9699003E7 -876000.0 -0.05 9.4015775E7 -8750000.0 -0.54 -0.4168 -0.7694 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G03 compound treatment 9.7628369E7 -2950000.0 -0.17 9.6193011E7 -6570000.0 -0.41 -0.4056 -0.9243 1264 SPBio_001401 OCc1ccccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G04 compound treatment 1.00470493E8 -104000.0 -0.01 9.6339425E7 -6430000.0 -0.4 -0.2844 -0.7177 1438 SPBio_001402 CC(C(=O)O)c1cccc(Oc2ccccc2)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G05 compound treatment 9.3671385E7 -6900000.0 -0.39 9.7952758E7 -4810000.0 -0.3 -0.4888 -0.9901 1447 SPBio_001403 NC(=O)c1ccccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G06 compound treatment 3.3005912E7 -6.76E7 -3.86 3.1095371E7 -7.17E7 -4.42 -5.8546 -0.9978 1036721 SPBio_001404 Oc1c(oc2ccccc2c1=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G07 compound treatment 9.4372847E7 -6200000.0 -0.35 9.726775E7 -5500000.0 -0.34 -0.4903 -0.9998 933 SPBio_001405 CN1C2C[C@@H](C[C@H]1[C@H]3OC32)OC(=O)[C@H](CO)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G08 compound treatment 9.3651391E7 -6920000.0 -0.4 9.8562323E7 -4200000.0 -0.26 -0.4631 -0.979 3100 SPBio_001406 COc1c2OCOc2cc3CCN(C)Cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G09 compound treatment 8.9943422E7 -1.06E7 -0.61 9.7397113E7 -5370000.0 -0.33 -0.6637 -0.9592 3174107 SPBio_001407 CN[C@@H]1C(O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(=CC[C@H]3N)CN)[C@@H]2O)OC[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G10 compound treatment 8.7324143E7 -1.33E7 -0.76 9.0253202E7 -1.25E7 -0.77 -1.0809 -1.0 802058 SPBio_001408 COc1cc(/C=C/C(=O)O)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G11 compound treatment 9.0126906E7 -1.04E7 -0.6 9.5635135E7 -7130000.0 -0.44 -0.7331 -0.9887 795 SPBio_001409 CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G12 compound treatment 8.7185557E7 -1.34E7 -0.77 8.8591222E7 -1.42E7 -0.87 -1.159 -0.9978 3173760 SPBio_001410 COc1cc2CCN(C)[C@@H]3Cc4cccc(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)c(O)c5)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G13 compound treatment 7.9201964E7 -2.14E7 -1.22 8.3974576E7 -1.88E7 -1.16 -1.6829 -0.9996 3059108 SPBio_001411 CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)C13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G14 compound treatment 9.3118719E7 -7460000.0 -0.43 9.9913573E7 -2850000.0 -0.18 -0.4257 -0.9234 1144 SPBio_001412 O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G15 compound treatment 9.110963E7 -9470000.0 -0.54 9.4784538E7 -7980000.0 -0.49 -0.7305 -0.9989 1155 SPBio_001413 Nc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G16 compound treatment 8.8588225E7 -1.2E7 -0.69 9.2201778E7 -1.06E7 -0.65 -0.9449 -0.9997 2081691 SPBio_001414 CC(=CCC/C(=C/CC/C(=C/CO)/C)/C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G17 compound treatment 9.2616544E7 -7960000.0 -0.45 9.6281259E7 -6490000.0 -0.4 -0.6043 -0.9979 878 SPBio_001415 CC(=O)NS(=O)(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G18 compound treatment 9.2400035E7 -8170000.0 -0.47 9.7281343E7 -5490000.0 -0.34 -0.5695 -0.9874 1203 SPBio_001416 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G19 compound treatment 9.0353376E7 -1.02E7 -0.58 9.2038085E7 -1.07E7 -0.66 -0.8807 -0.9981 1159 SPBio_001417 Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G20 compound treatment 9.4732166E7 -5840000.0 -0.33 9.4682734E7 -8080000.0 -0.5 -0.5885 -0.981 1346 SPBio_001418 CCN(CC)CCNC(=O)COc1ccc(OC)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G21 compound treatment 9.6702557E7 -3870000.0 -0.22 9.5707937E7 -7060000.0 -0.44 -0.4642 -0.9508 1177 SPBio_001419 Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G22 compound treatment 9.4566184E7 -6010000.0 -0.34 1.01068239E8 -1700000.0 -0.1 -0.3169 -0.8826 1210 SPBio_001420 CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G23 mock treatment 8.8879723E7 -1.17E7 -0.67 9.2886875E7 -9880000.0 -0.61 -0.9033 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 G24 mock treatment 1.03443952E8 2870000.0 0.16 1.06924183E8 4160000.0 0.26 0.2971 0.9767 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H01 mock treatment 9.9210454E7 -1360000.0 -0.08 9.9450152E7 -3320000.0 -0.2 -0.1997 -0.9127 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H02 mock treatment 9.463704E7 -5940000.0 -0.34 9.2764952E7 -1.0E7 -0.62 -0.6759 -0.9604 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H03 compound treatment 9.625598E7 -4320000.0 -0.25 9.4636159E7 -8130000.0 -0.5 -0.5289 -0.9468 1364 SPBio_001421 OC(=O)/C(=C/c1cccc(O)c1)/C#N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H04 compound treatment 9.6094552E7 -4480000.0 -0.26 1.0236987E8 -397000.0 -0.02 -0.1984 -0.7712 3173855 SPBio_001422 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H05 compound treatment 8.091715E7 -1.97E7 -1.12 7.8223106E7 -2.45E7 -1.51 -1.8642 -0.9893 829 SPBio_001423 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H06 compound treatment 8.7339064E7 -1.32E7 -0.76 9.7480239E7 -5290000.0 -0.33 -0.7653 -0.9292 1270 SPBio_001424 C[N+](C)(C)CCCCCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H07 compound treatment 9.0663962E7 -9910000.0 -0.57 9.6113278E7 -6650000.0 -0.41 -0.6906 -0.9874 3061087 SPBio_001425 NC/C=C/C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H08 compound treatment 8.7961666E7 -1.26E7 -0.72 9.0724184E7 -1.2E7 -0.74 -1.0347 -0.9999 1242 SPBio_001426 CN(CS(=O)(=O)O)c1c(C)n(C)n(c2ccccc2)c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H09 compound treatment 8.8286212E7 -1.23E7 -0.7 9.6618699E7 -6150000.0 -0.38 -0.7646 -0.9581 3684 SPBio_001427 OC(=O)C1=CCCNC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H10 compound treatment 2.6720507E7 -7.39E7 -4.22 2.7737158E7 -7.5E7 -4.63 -6.255 -0.999 1342 SPBio_001428 CN(C)C(=S)SSC(=S)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H11 compound treatment 8.673878E7 -1.38E7 -0.79 9.1779848E7 -1.1E7 -0.68 -1.0381 -0.997 1923 SPBio_001429 NC1(CC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H12 compound treatment 8.6902777E7 -1.37E7 -0.78 9.1043807E7 -1.17E7 -0.72 -1.0635 -0.9992 3173628 SPBio_001430 CN1C(C)(C)CCCC1(C)C.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H13 compound treatment 8.650128E7 -1.41E7 -0.8 9.2323216E7 -1.04E7 -0.64 -1.024 -0.9939 1111718 SPBio_001431 NC1(CCC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H14 compound treatment 4.6913456E7 -5.37E7 -3.07 5.0633584E7 -5.21E7 -3.21 -4.441 -0.9997 758 SPBio_001432 CCCOc1ccc2nc(NC(=O)OC)[nH]c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H15 compound treatment 8.8881744E7 -1.17E7 -0.67 9.6362577E7 -6400000.0 -0.39 -0.7517 -0.9685 121 SPBio_001433 OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H16 compound treatment 3.1134486E7 -6.94E7 -3.97 3.2692827E7 -7.01E7 -4.32 -5.8606 -0.9991 1410 SPBio_001434 S=P(N1CC1)(N2CC2)N3CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H17 compound treatment 9.0705273E7 -9870000.0 -0.56 9.5182482E7 -7580000.0 -0.47 -0.7295 -0.9957 1594 SPBio_001435 N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H18 compound treatment 8.9756591E7 -1.08E7 -0.62 9.5062922E7 -7700000.0 -0.47 -0.773 -0.9915 1080 SPBio_001436 N[C@H](Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H19 compound treatment 9.2915677E7 -7660000.0 -0.44 9.760482E7 -5160000.0 -0.32 -0.5345 -0.9877 1458 SPBio_001437 NC(Cc1ccc(Cl)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H20 compound treatment 8.9868587E7 -1.07E7 -0.61 9.2136082E7 -1.06E7 -0.66 -0.8961 -0.9994 1528 SPBio_001438 NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H21 compound treatment 8.9576987E7 -1.1E7 -0.63 9.4606027E7 -8160000.0 -0.5 -0.8002 -0.9939 3198954 SPBio_001439 CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H22 compound treatment 6.9720107E7 -3.09E7 -1.76 7.9942022E7 -2.28E7 -1.41 -2.2418 -0.9937 846 SPBio_001440 Cc1nc2sccn2c(=O)c1CCN3CCC(=C(c4ccc(F)cc4)c5ccc(F)cc5)CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H23 mock treatment 9.7791508E7 -2780000.0 -0.16 9.7800681E7 -4970000.0 -0.31 -0.329 -0.9535 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 H24 mock treatment 1.01886281E8 1310000.0 0.07 1.02127842E8 -639000.0 -0.04 0.0251 0.2968 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I01 mock treatment 9.9797097E7 -778000.0 -0.04 1.01239693E8 -1530000.0 -0.09 -0.098 -0.9413 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I02 mock treatment 1.01667655E8 1090000.0 0.06 9.5932447E7 -6830000.0 -0.42 -0.2537 -0.5958 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I03 compound treatment 9.7534435E7 -3040000.0 -0.17 9.4978958E7 -7790000.0 -0.48 -0.4623 -0.9056 934 SPBio_001441 Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I04 compound treatment 4.6072387E7 -5.45E7 -3.11 4.9014381E7 -5.38E7 -3.31 -4.5455 -0.9995 1350 SPBio_001442 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I05 compound treatment 9.0154658E7 -1.04E7 -0.6 9.7131751E7 -5640000.0 -0.35 -0.6667 -0.9671 799 SPBio_001443 Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I06 compound treatment 2.7554061E7 -7.3E7 -4.17 2.8648943E7 -7.41E7 -4.57 -6.1816 -0.999 1233 SPBio_001444 CO[C@@H]1[C@@H](O)[C@H](C)O[C@H](O[C@H]2CC[C@@]3(C=O)[C@H](CCC4C3CC[C@]5(C)[C@H](CC[C@]45O)C6=CC(=O)OC6)C2)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I07 compound treatment 9.0490229E7 -1.01E7 -0.58 9.4709546E7 -8060000.0 -0.5 -0.7588 -0.9973 867 SPBio_001445 Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I08 compound treatment 8.6401627E7 -1.42E7 -0.81 9.4610964E7 -8160000.0 -0.5 -0.9283 -0.9737 3173860 SPBio_001446 O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5OC1[C@]2(CCN3CC6CCC6)c54 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I09 compound treatment 7.6786134E7 -2.38E7 -1.36 8.5604088E7 -1.72E7 -1.06 -1.7095 -0.9923 753 SPBio_001447 O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I10 compound treatment 8.6985464E7 -1.36E7 -0.78 9.278849E7 -9980000.0 -0.62 -0.9841 -0.9933 714 SPBio_001448 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc2ccc(OC)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I11 compound treatment 8.5058692E7 -1.55E7 -0.89 9.236894E7 -1.04E7 -0.64 -1.0803 -0.9873 1192 SPBio_001449 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I12 compound treatment 5.9848433E7 -4.07E7 -2.33 6.7317326E7 -3.54E7 -2.19 -3.191 -0.9995 3174345 SPBio_001450 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N.OC(=O)c1cc(ccc1O)S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I13 compound treatment 8.4021259E7 -1.66E7 -0.95 9.2248707E7 -1.05E7 -0.65 -1.1274 -0.983 1212 SPBio_001451 CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I14 compound treatment 8.3742243E7 -1.68E7 -0.96 9.0421752E7 -1.23E7 -0.76 -1.2184 -0.9933 1291 SPBio_001452 CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I15 compound treatment 8.8555682E7 -1.2E7 -0.69 9.6424015E7 -6340000.0 -0.39 -0.7622 -0.9643 743 SPBio_001453 CC(C)(C)NCC(O)c1cc(O)cc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I16 compound treatment 8.9196329E7 -1.14E7 -0.65 9.4377781E7 -8390000.0 -0.52 -0.8255 -0.9936 728 SPBio_001454 Cc1cc(nnc1NCCN2CCOCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I17 compound treatment 9.230994E7 -8270000.0 -0.47 9.8524884E7 -4240000.0 -0.26 -0.5189 -0.9611 1218 SPBio_001455 CCCCNc1ccc(cc1)C(=O)OCCN(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I18 compound treatment 8.8011226E7 -1.26E7 -0.72 8.1007513E7 -2.18E7 -1.34 -1.4562 -0.9571 733 SPBio_001456 CC1(CC2CC3(C)C1)CC(N)(C2)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I19 compound treatment 9.439089E7 -6180000.0 -0.35 9.3030206E7 -9740000.0 -0.6 -0.6743 -0.9681 1418 SPBio_001457 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I20 compound treatment 9.137236E7 -9200000.0 -0.53 9.2065022E7 -1.07E7 -0.66 -0.8384 -0.9937 983 SPBio_001458 NCCCS(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I21 compound treatment 9.093803E7 -9640000.0 -0.55 9.1664338E7 -1.11E7 -0.68 -0.8734 -0.9942 1444 SPBio_001459 C1CN=C(N1)C2CCCc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I22 compound treatment 9.1337591E7 -9240000.0 -0.53 9.0015752E7 -1.28E7 -0.79 -0.9291 -0.9812 840551 SPBio_001460 NCCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I23 mock treatment 9.2590612E7 -7980000.0 -0.46 9.7702366E7 -5060000.0 -0.31 -0.5434 -0.9829 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 I24 mock treatment 1.02556882E8 1980000.0 0.11 1.07311159E8 4540000.0 0.28 0.2782 0.9206 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J01 mock treatment 9.8687718E7 -1890000.0 -0.11 9.9494003E7 -3270000.0 -0.2 -0.2189 -0.957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J02 mock treatment 1.0017529E8 -400000.0 -0.02 9.4595613E7 -8170000.0 -0.5 -0.3723 -0.7384 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J03 compound treatment 9.6955086E7 -3620000.0 -0.21 9.2151037E7 -1.06E7 -0.65 -0.609 -0.8874 3471022 SPBio_001461 CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J04 compound treatment 9.1136219E7 -9440000.0 -0.54 9.296799E7 -9800000.0 -0.6 -0.8086 -0.9984 3173083 SPBio_001462 CO[C@H]1[C@H](O)CC(=O)O[C@@H](C)C/C=C/C=C/[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J05 compound treatment 9.2220316E7 -8350000.0 -0.48 9.6468037E7 -6300000.0 -0.39 -0.6122 -0.9947 1581 SPBio_001463 CNC(=N)NCCCC(N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J06 compound treatment 8.3310618E7 -1.73E7 -0.99 8.5815749E7 -1.7E7 -1.04 -1.4366 -0.9996 115 SPBio_001464 COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J07 compound treatment 8.2376274E7 -1.82E7 -1.04 8.9050292E7 -1.37E7 -0.85 -1.3333 -0.9947 869 SPBio_001465 CCC1(C)CC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J08 compound treatment 8.3312387E7 -1.73E7 -0.99 9.5083028E7 -7680000.0 -0.47 -1.0326 -0.9435 839 SPBio_001466 Nc1nc2n(COCCO)cnc2c(=O)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J09 compound treatment 8.853277E7 -1.2E7 -0.69 9.5240343E7 -7530000.0 -0.46 -0.8147 -0.9816 3172968 SPBio_001467 CCC1NC(=O)C(C(O)C(C)C/C=C/C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J10 compound treatment 8.1911001E7 -1.87E7 -1.07 9.0977447E7 -1.18E7 -0.73 -1.2681 -0.9825 897 SPBio_001468 CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J11 compound treatment 8.280077E7 -1.78E7 -1.02 9.3601656E7 -9170000.0 -0.56 -1.1178 -0.9617 3173475 SPBio_001469 CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@@H]([C@H]3OC(=O)C)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](OC(=O)C)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J12 compound treatment 7.7073878E7 -2.35E7 -1.34 8.3942043E7 -1.88E7 -1.16 -1.7703 -0.9973 117 SPBio_001470 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J13 compound treatment 7.7331095E7 -2.32E7 -1.33 8.8179779E7 -1.46E7 -0.9 -1.5752 -0.9819 3198430 SPBio_001471 CC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(F)(F)F)C(C)C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J14 compound treatment 2.7228729E7 -7.33E7 -4.19 2.819098E7 -7.46E7 -4.6 -6.2147 -0.9989 1417 SPBio_001472 CCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J15 compound treatment 8.5631483E7 -1.49E7 -0.85 9.4110184E7 -8660000.0 -0.53 -0.9812 -0.9744 3079212 SPBio_001473 NCCCN.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J16 compound treatment 8.7471935E7 -1.31E7 -0.75 9.694271E7 -5820000.0 -0.36 -0.7834 -0.9433 757 SPBio_001474 OC(=O)c1cn(C2CC2)c3cc(N4CCNCC4)c(F)cc3c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J17 compound treatment 8.5482978E7 -1.51E7 -0.86 9.1006496E7 -1.18E7 -0.72 -1.1225 -0.9963 3198431 SPBio_001475 CC(C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J18 compound treatment 8.6509104E7 -1.41E7 -0.8 9.0978029E7 -1.18E7 -0.73 -1.0823 -0.9987 1038 SPBio_001476 O=C1CCCN1CC#CCN2CCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J19 compound treatment 8.5417633E7 -1.52E7 -0.87 8.0183087E7 -2.26E7 -1.39 -1.5969 -0.9739 1095029 SPBio_001477 CCCCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J20 compound treatment 8.970111E7 -1.09E7 -0.62 8.851585E7 -1.43E7 -0.88 -1.0606 -0.9856 382 SPBio_001478 NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J21 compound treatment 9.1847612E7 -8730000.0 -0.5 9.4852716E7 -7910000.0 -0.49 -0.6977 -0.9999 3079213 SPBio_001479 N[C@@H](CCC(=O)N[C@@H](CCSC(CC(=O)O)C(=O)O)C(=O)NCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J22 compound treatment 9.1836158E7 -8740000.0 -0.5 9.225154E7 -1.05E7 -0.65 -0.8115 -0.9917 1512 SPBio_001480 CC(C)NCC(O)c1ccc2ccccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J23 mock treatment 1.01102929E8 528000.0 0.03 1.05224411E8 2460000.0 0.15 0.1284 0.8316 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 J24 mock treatment 1.01802716E8 1230000.0 0.07 1.04814901E8 2050000.0 0.13 0.1389 0.9616 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K01 mock treatment 9.9842356E7 -733000.0 -0.04 1.01618493E8 -1150000.0 -0.07 -0.0797 -0.9686 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K02 mock treatment 9.9124852E7 -1450000.0 -0.08 8.6591308E7 -1.62E7 -1.0 -0.7637 -0.7632 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K03 compound treatment 9.4240623E7 -6330000.0 -0.36 8.9879721E7 -1.29E7 -0.79 -0.8177 -0.9367 737 SPBio_001481 c1nc(cs1)c2nc3ccccc3[nH]2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K04 compound treatment 9.4614814E7 -5960000.0 -0.34 9.6135111E7 -6630000.0 -0.41 -0.5299 -0.9959 723 SPBio_001482 CC(C)NCC(O)COc1ccc(CC(=O)N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K05 compound treatment 2.8773381E7 -7.18E7 -4.1 3.2536425E7 -7.02E7 -4.33 -5.9629 -0.9996 731 SPBio_001483 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K06 compound treatment 9.8862193E7 -1710000.0 -0.1 1.0153417E8 -1230000.0 -0.08 -0.123 -0.9922 990 SPBio_001484 CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K07 compound treatment 7.1384394E7 -2.92E7 -1.67 7.0231829E7 -3.25E7 -2.01 -2.5978 -0.9958 972 SPBio_001485 CN(C)S(=O)(=O)c1ccc2Sc3ccccc3/C(=C\CCN4CCN(C)CC4)/c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K08 compound treatment 8.7495378E7 -1.31E7 -0.75 9.5139509E7 -7630000.0 -0.47 -0.861 -0.975 338 SPBio_001486 Nc1ccncc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K09 compound treatment 8.6172836E7 -1.44E7 -0.82 9.576244E7 -7000000.0 -0.43 -0.8873 -0.9547 833 SPBio_001487 CC(C)(C)NC[C@@H](O)COc1nsnc1N2CCOCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K10 compound treatment 5.561237E7 -4.5E7 -2.57 5.4318638E7 -4.84E7 -2.99 -3.9288 -0.9972 783 SPBio_001488 CO[C@@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]2Cc4cn(C)c5cccc1c45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K11 compound treatment 8.4958392E7 -1.56E7 -0.89 9.3343715E7 -9420000.0 -0.58 -1.0418 -0.9784 2572 SPBio_001489 COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c32)cc7)N(C)CCc6cc5OC)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K12 compound treatment 7.0432501E7 -3.01E7 -1.72 7.0231361E7 -3.25E7 -2.01 -2.6363 -0.9971 86 SPBio_001490 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCN(C)Cc3ccccc3)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K13 compound treatment 6.9065283E7 -3.15E7 -1.8 7.628015E7 -2.65E7 -1.63 -2.4279 -0.9988 1000109 SPBio_001491 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K14 compound treatment 8.4723069E7 -1.59E7 -0.91 9.4883437E7 -7880000.0 -0.49 -0.9842 -0.9574 1016 SPBio_001492 CN1CCOC(c2ccccc2)c3ccccc3C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K15 compound treatment 8.4517248E7 -1.61E7 -0.92 9.0456541E7 -1.23E7 -0.76 -1.1855 -0.9955 883 SPBio_001493 CC(Oc1ccccc1)C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K16 compound treatment 8.5673025E7 -1.49E7 -0.85 9.2204418E7 -1.06E7 -0.65 -1.0626 -0.9912 786 SPBio_001494 CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K17 compound treatment 9.1170503E7 -9400000.0 -0.54 9.5365109E7 -7400000.0 -0.46 -0.7027 -0.9967 824 SPBio_001495 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@@](O)(C(=O)OC)n4c5ccccc35 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K18 compound treatment 8.9793837E7 -1.08E7 -0.62 9.2937392E7 -9830000.0 -0.61 -0.8641 -1.0 741 SPBio_001496 Cc1ccccc1OCC(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K19 compound treatment 9.2879642E7 -7700000.0 -0.44 9.5196515E7 -7570000.0 -0.47 -0.641 -0.9996 1052 SPBio_001497 CC[C@H]1CN2CCC1C[C@@H]2[C@@H](O)c3ccnc4ccc(OC)cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K20 compound treatment 9.4316553E7 -6260000.0 -0.36 9.6722863E7 -6040000.0 -0.37 -0.5164 -0.9998 751 SPBio_001498 COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K21 compound treatment 9.7797128E7 -2780000.0 -0.16 9.8580944E7 -4190000.0 -0.26 -0.2947 -0.9728 1223 SPBio_001499 CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K22 compound treatment 8.9981776E7 -1.06E7 -0.61 9.3340474E7 -9430000.0 -0.58 -0.839 -0.9998 1241 SPBio_001500 NC(=N)NS(=O)(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K23 mock treatment 9.1908946E7 -8670000.0 -0.5 9.4985969E7 -7780000.0 -0.48 -0.6894 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 K24 mock treatment 9.9790574E7 -784000.0 -0.04 1.00264567E8 -2500000.0 -0.15 -0.1408 -0.8763 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L01 mock treatment 1.08276178E8 7700000.0 0.44 1.02003015E8 -764000.0 -0.05 0.2779 0.6279 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L02 mock treatment 8.4571851E7 -1.6E7 -0.91 9.0198675E7 -1.26E7 -0.77 -1.1946 -0.9966 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L03 compound treatment 9.5488155E7 -5090000.0 -0.29 1.00227107E8 -2540000.0 -0.16 -0.3163 -0.9578 3198432 SPBio_001501 CSC(=N)NCCC[C@@H](N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L04 compound treatment 8.6922019E7 -1.37E7 -0.78 8.808502E7 -1.47E7 -0.91 -1.1917 -0.9973 1269 SPBio_001502 CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L05 compound treatment 8.8831821E7 -1.17E7 -0.67 8.9875783E7 -1.29E7 -0.79 -1.0365 -0.9965 3198433 SPBio_001503 NC(Cc1c[nH]cn1)C(=O)Nc2ccc3ccccc3c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L06 compound treatment 8.8762166E7 -1.18E7 -0.68 9.3970092E7 -8800000.0 -0.54 -0.8608 -0.9941 1486 SPBio_001504 CC(C)NCC(O)COc1ccc(NC(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L07 compound treatment 2.747351E7 -7.31E7 -4.18 2.8326582E7 -7.44E7 -4.59 -6.1989 -0.9989 3176939 SPBio_001505 ClCC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L08 compound treatment 8.5396112E7 -1.52E7 -0.87 9.2295821E7 -1.05E7 -0.65 -1.0698 -0.9894 1415 SPBio_001506 FC(F)(F)c1cccc(c1)N2CCNCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L09 compound treatment 8.5822918E7 -1.48E7 -0.84 9.5779954E7 -6990000.0 -0.43 -0.9007 -0.9514 3198434 SPBio_001507 NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L10 compound treatment 8.0177705E7 -2.04E7 -1.17 9.0987927E7 -1.18E7 -0.73 -1.3377 -0.974 419 SPBio_001508 CC1=NN(C(=O)C1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L11 compound treatment 8.0046854E7 -2.05E7 -1.17 8.9247251E7 -1.35E7 -0.83 -1.4189 -0.986 3079214 SPBio_001509 CC(C)CC(NC(=O)CN)C(=O)NC(Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L12 compound treatment 7.3025245E7 -2.75E7 -1.57 8.001078E7 -2.28E7 -1.4 -2.1052 -0.9983 907188 SPBio_001510 COc1cccc(OC)c1OCCNCC2COc3ccccc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L13 compound treatment 7.7737786E7 -2.28E7 -1.31 8.9470659E7 -1.33E7 -0.82 -1.5025 -0.9749 3198435 SPBio_001511 N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L14 compound treatment 5.0837638E7 -4.97E7 -2.84 5.6081616E7 -4.67E7 -2.88 -4.0449 -1.0 1478 SPBio_001512 Cc1ccc(cc1)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L15 compound treatment 6.4430256E7 -3.61E7 -2.07 6.8380803E7 -3.44E7 -2.12 -2.9595 -0.9999 2269 SPBio_001513 Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L16 compound treatment 8.0971808E7 -1.96E7 -1.12 8.8118245E7 -1.46E7 -0.9 -1.4307 -0.9943 445 SPBio_001514 NC(=O)c1cccc(N)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L17 compound treatment 8.9752083E7 -1.08E7 -0.62 9.4497706E7 -8270000.0 -0.51 -0.7978 -0.9954 3054972 SPBio_001515 CC(C)C1=CC2=CCC3[C@](C)(CCC[C@]3(C)C2CC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L18 compound treatment 8.3788451E7 -1.68E7 -0.96 8.3359996E7 -1.94E7 -1.2 -1.5243 -0.994 1248 SPBio_001516 C[C@@]12CCC3C(CCc4cc(OC(=O)CCC(=O)O)ccc34)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L19 compound treatment 9.1670628E7 -8900000.0 -0.51 9.4788213E7 -7980000.0 -0.49 -0.7076 -0.9999 3079215 SPBio_001517 CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L20 compound treatment 9.0942844E7 -9630000.0 -0.55 9.6866401E7 -5900000.0 -0.36 -0.6465 -0.9798 2060318 SPBio_001518 C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@]12O[C@]2(C)C[C@@H](O)CC1(C)C)/C=C/C=C(\C)/C=C/C3=C(C)C[C@@H](O)CC3(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L21 compound treatment 8.8104759E7 -1.25E7 -0.71 9.0969308E7 -1.18E7 -0.73 -1.0182 -0.9999 740 SPBio_001519 N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L22 compound treatment 8.3394515E7 -1.72E7 -0.98 8.9094893E7 -1.37E7 -0.84 -1.2902 -0.9971 1023 SPBio_001520 CN[C@H](CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L23 mock treatment 9.0789809E7 -9790000.0 -0.56 9.3039352E7 -9730000.0 -0.6 -0.8195 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 L24 mock treatment 1.01981211E8 1410000.0 0.08 1.04041349E8 1270000.0 0.08 0.1124 0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M01 mock treatment 1.14373706E8 1.38E7 0.79 1.18570298E8 1.58E7 0.97 1.2465 0.9945 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M02 mock treatment 1.04962323E8 4390000.0 0.25 1.06340407E8 3570000.0 0.22 0.3331 0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M03 compound treatment 9.7348694E7 -3230000.0 -0.18 9.2244595E7 -1.05E7 -0.65 -0.589 -0.8735 2069343 SPBio_001521 COc1ccc2[C@H](OC(=O)c2c1OC)[C@H]3N(C)CCc4cc5OCOc5cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M04 compound treatment 9.7120043E7 -3450000.0 -0.2 9.7100175E7 -5670000.0 -0.35 -0.3866 -0.9635 1529 SPBio_001522 COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M05 compound treatment 8.825288E7 -1.23E7 -0.7 9.0808971E7 -1.2E7 -0.74 -1.0192 -0.9997 949 SPBio_001523 OC(=O)c1cc(O)c2ccccc2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M06 compound treatment 5.7547465E7 -4.3E7 -2.46 4.5508776E7 -5.73E7 -3.53 -4.2346 -0.9844 871 SPBio_001524 Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M07 compound treatment 8.8433598E7 -1.21E7 -0.69 9.5617256E7 -7150000.0 -0.44 -0.8023 -0.976 362 SPBio_001525 CCN(CC)CC(=O)Nc1c(C)cccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M08 compound treatment 9.3322168E7 -7250000.0 -0.41 1.01225494E8 -1540000.0 -0.1 -0.3603 -0.8472 3480067 SPBio_001526 CC(NCCc1ccc(O)cc1)C(O)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M09 compound treatment 8.6410514E7 -1.42E7 -0.81 9.4530101E7 -8240000.0 -0.51 -0.9314 -0.9747 988 SPBio_001527 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M10 compound treatment 8.2701399E7 -1.79E7 -1.02 9.5446824E7 -7320000.0 -0.45 -1.0414 -0.9325 3058009 SPBio_001528 CCN1CCC(CNC(=O)c2cc(ccc2OC)S(=O)(=O)N)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M11 compound treatment 8.0234025E7 -2.03E7 -1.16 8.9679453E7 -1.31E7 -0.81 -1.3925 -0.9841 898 SPBio_001529 CCOC(=O)C(Cc1ccc(O)cc1)NC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M12 compound treatment 8.7787257E7 -1.28E7 -0.73 9.731878E7 -5450000.0 -0.34 -0.7543 -0.9378 1068 SPBio_001530 CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(CN(C)C)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M13 compound treatment 8.0763666E7 -1.98E7 -1.13 8.958633E7 -1.32E7 -0.81 -1.3751 -0.9868 993 SPBio_001531 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M14 compound treatment 8.2311893E7 -1.83E7 -1.04 9.2118312E7 -1.06E7 -0.66 -1.2022 -0.975 1180 SPBio_001532 Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M15 compound treatment 8.541663E7 -1.52E7 -0.87 9.0941242E7 -1.18E7 -0.73 -1.128 -0.9963 1073 SPBio_001533 CC(N)C(=O)NC(Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M16 compound treatment 2.7629199E7 -7.29E7 -4.17 2.841952E7 -7.43E7 -4.58 -6.1886 -0.9989 998 SPBio_001534 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M17 compound treatment 8.9692497E7 -1.09E7 -0.62 9.0955442E7 -1.18E7 -0.73 -0.9546 -0.9969 1017 SPBio_001535 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M18 compound treatment 8.5668928E7 -1.49E7 -0.85 9.2307598E7 -1.05E7 -0.64 -1.0583 -0.9906 1094 SPBio_001536 COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M19 compound treatment 9.0077733E7 -1.05E7 -0.6 9.4200306E7 -8570000.0 -0.53 -0.7976 -0.998 1034 SPBio_001537 CC(=O)N[C@@H](CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M20 compound treatment 8.7893338E7 -1.27E7 -0.72 9.0777635E7 -1.2E7 -0.74 -1.0351 -1.0 887 SPBio_001538 COc1ccc(NS(=O)(=O)c2ccc(N)cc2)nn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M21 compound treatment 8.9099965E7 -1.15E7 -0.66 9.4529615E7 -8240000.0 -0.51 -0.8228 -0.992 1523 SPBio_001539 CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M22 compound treatment 6.6914689E7 -3.37E7 -1.92 7.0519009E7 -3.22E7 -1.99 -2.7659 -0.9999 1102 SPBio_001540 CC(C(=O)O)c1ccc(cc1)C(=O)c2cccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M23 mock treatment 9.2040262E7 -8530000.0 -0.49 9.5808414E7 -6960000.0 -0.43 -0.6482 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 M24 mock treatment 1.0335718E8 2780000.0 0.16 1.06264916E8 3500000.0 0.22 0.2649 0.9888 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N01 mock treatment 1.13531149E8 1.3E7 0.74 1.11955577E8 9190000.0 0.57 0.9241 0.9912 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N02 mock treatment 1.04031202E8 3460000.0 0.2 1.0459343E8 1830000.0 0.11 0.2193 0.9645 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N03 compound treatment 7.4357365E7 -2.62E7 -1.5 7.9114498E7 -2.37E7 -1.46 -2.0905 -0.9999 3054980 SPBio_001541 Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](CO)O3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N04 compound treatment 9.2268336E7 -8310000.0 -0.47 9.4109297E7 -8660000.0 -0.53 -0.7131 -0.9983 3174610 SPBio_001542 COc1cc(cc(OC)c1OC)C(=O)O[C@H]2CC[C@@]3(C)[C@@H]4CC[C@@H]5[C@@]3(C[C@@]6(O)[C@@H]7CN8C[C@@H](C)CC[C@H]8[C@@](C)(O)[C@@]7(O)[C@@H](O)C[C@@]56O)O[C@@]42O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N05 compound treatment 8.875837E7 -1.18E7 -0.68 9.421807E7 -8550000.0 -0.53 -0.8502 -0.9925 2060304 SPBio_001543 OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N06 compound treatment 7.9357261E7 -2.12E7 -1.21 8.7345928E7 -1.54E7 -0.95 -1.5296 -0.9927 882 SPBio_001544 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N07 compound treatment 8.2025809E7 -1.85E7 -1.06 9.3521544E7 -9250000.0 -0.57 -1.1526 -0.9576 2060308 SPBio_001545 C/C(=C/C(=O)O)/C=C/C1(O)C(=CC(=O)CC1(C)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N08 compound treatment 8.0904302E7 -1.97E7 -1.12 8.8730755E7 -1.4E7 -0.87 -1.4067 -0.9916 3198436 SPBio_001546 CO[C@H]1CC(O[C@H]/2[C@@H](C)\C=C\C=C\3/CO[C@@H]4\C(=N/O)\C(=C[C@@H](C(=O)O[C@H]5C[C@@H](C\C=C2/C)O[C@@]6(CC[C@H](C)[C@H](O6)C7CCCCC7)C5)[C@@]43O)C)O[C@@H](C)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N09 compound treatment 6.895205E7 -3.16E7 -1.81 7.7600328E7 -2.52E7 -1.55 -2.3749 -0.9971 1039 SPBio_001547 CC[C@]1(CCCN2CCc3c4[C@@H]21)CC(=O)n4c5ccccc35 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N10 compound treatment 7.0299095E7 -3.03E7 -1.73 8.0650177E7 -2.21E7 -1.36 -2.1875 -0.993 1389 SPBio_001548 CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc4cccnc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N11 compound treatment 7.6912909E7 -2.37E7 -1.35 9.203234E7 -1.07E7 -0.66 -1.4241 -0.9459 1583 SPBio_001549 COc1ccc(/C=C/c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N12 compound treatment 7.1731091E7 -2.88E7 -1.65 7.8830537E7 -2.39E7 -1.48 -2.209 -0.9985 3174609 SPBio_001550 CC(C)c1c(C(=O)c2ccccc2)c(c(c3ccc(F)cc3)n1CC[C@@H](O)C[C@@H](O)CC(=O)O)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N13 compound treatment 7.8787725E7 -2.18E7 -1.25 8.4598319E7 -1.82E7 -1.12 -1.6724 -0.9986 1010348 SPBio_001551 OC1=CC(=O)c2ccccc2C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N14 compound treatment 7.636793E7 -2.42E7 -1.38 8.0736312E7 -2.2E7 -1.36 -1.9385 -1.0 3172973 SPBio_001552 COC(=O)[C@@]1(O)OC[C@]2(C3[C@H]4OC[C@@]3([C@@H](C[C@@H]2OC(=O)/C(=C/C)/C)OC(=O)C)C(=O)OC)[C@@H]1[C@@](C)([C@@H]4O)C56O[C@@]6(C)[C@H]7C[C@@H]5OC8OC=C[C@]78O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N15 compound treatment 7.3811063E7 -2.68E7 -1.53 7.4259807E7 -2.85E7 -1.76 -2.3242 -0.9976 3054057 SPBio_001553 CC(=CCC/C(=C/CCC(C)(O)C=C)/C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N16 compound treatment 2.8464809E7 -7.21E7 -4.12 2.9082693E7 -7.37E7 -4.54 -6.1259 -0.9988 1520 SPBio_001554 CC[n+]1c(c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N17 compound treatment 8.626145E7 -1.43E7 -0.82 9.0179423E7 -1.26E7 -0.78 -1.1271 -0.9997 1002002 SPBio_001555 O[C@@H]1CC(=C[C@@H](O)[C@H]1O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N18 compound treatment 3.3004752E7 -6.76E7 -3.86 3.4413977E7 -6.84E7 -4.21 -5.71 -0.9991 1457 SPBio_001556 CC(=O)OCC(=O)[C@]12OC3(CCCC3)O[C@@H]2CC4C5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@@]41C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N19 compound treatment 4.9061099E7 -5.15E7 -2.94 5.0988688E7 -5.18E7 -3.19 -4.3387 -0.9992 797 SPBio_001557 CC[C@]1(CC[C@@H](O1)[C@]2(C)CCC3(C[C@H](O)[C@@H](C)[C@H](O3)[C@H](C)[C@@H](OC)[C@H](C)C(=O)O)O2)C4O[C@H](C[C@@H]4C)C5O[C@@](O)(CC)[C@H](C)C[C@@H]5C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N20 compound treatment 8.5555829E7 -1.5E7 -0.86 9.0952409E7 -1.18E7 -0.73 -1.1219 -0.9967 1357 SPBio_001558 CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N21 compound treatment 9.0857252E7 -9720000.0 -0.56 8.881812E7 -1.39E7 -0.86 -1.0007 -0.9776 1000111 SPBio_001559 OC(=O)CCCCC1SCC2NC(=O)NC12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N22 compound treatment 9.4668623E7 -5910000.0 -0.34 9.0302817E7 -1.25E7 -0.77 -0.782 -0.9318 864 SPBio_001560 Oc1noc2CNCCc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N23 mock treatment 9.160465E7 -8970000.0 -0.51 9.1996381E7 -1.08E7 -0.66 -0.832 -0.9918 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 N24 mock treatment 1.01159919E8 585000.0 0.03 1.01605693E8 -1160000.0 -0.07 -0.027 -0.3415 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O01 mock treatment 1.04153211E8 3580000.0 0.2 1.10547099E8 7780000.0 0.48 0.4837 0.9278 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O02 mock treatment 9.5484814E7 -5090000.0 -0.29 9.98205E7 -2950000.0 -0.18 -0.3341 -0.9743 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O03 compound treatment 8.8347603E7 -1.22E7 -0.7 9.2617954E7 -1.01E7 -0.63 -0.9365 -0.9985 1407 SPBio_001561 NC(COCc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O04 compound treatment 9.2965329E7 -7610000.0 -0.43 9.344534E7 -9320000.0 -0.57 -0.7138 -0.9906 1237 SPBio_001562 CC(=O)Nc1ccc(OC(=O)c2ccccc2O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O05 compound treatment 8.2210305E7 -1.84E7 -1.05 9.9675069E7 -3090000.0 -0.19 -0.8769 -0.8221 1026 SPBio_001563 CC(=O)NC(Cc1ccccc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O06 compound treatment 8.5810025E7 -1.48E7 -0.84 9.8100784E7 -4670000.0 -0.29 -0.8001 -0.8974 821 SPBio_001564 O=C1NS(=O)(=O)c2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O07 compound treatment 7.8829196E7 -2.17E7 -1.24 9.6696539E7 -6070000.0 -0.37 -1.1434 -0.8809 987 SPBio_001565 CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O08 compound treatment 7.1948903E7 -2.86E7 -1.64 9.0989777E7 -1.18E7 -0.73 -1.6702 -0.9331 1122 SPBio_001566 N(=Nc1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O09 compound treatment 7.9448375E7 -2.11E7 -1.21 9.7231415E7 -5540000.0 -0.34 -1.0951 -0.8728 874 SPBio_001567 CC(C)CC(NC(=O)CCN)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O10 compound treatment 8.0832791E7 -1.97E7 -1.13 9.4529533E7 -8240000.0 -0.51 -1.1569 -0.935 738 SPBio_001568 CC(=O)Nc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O11 compound treatment 7.5973805E7 -2.46E7 -1.41 9.0450471E7 -1.23E7 -0.76 -1.531 -0.9582 2060457 SPBio_001569 COc1cc(O)c2c(=O)cc(oc2c1)c3ccc(O)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O12 compound treatment 7.45632E7 -2.6E7 -1.49 8.7579934E7 -1.52E7 -0.94 -1.7132 -0.9751 684 SPBio_001570 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(=O)CC)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O13 compound treatment 7.6596962E7 -2.4E7 -1.37 8.6602414E7 -1.62E7 -1.0 -1.6736 -0.9877 1006104 SPBio_001571 Cc1cc(=O)oc2cc(O)cc(O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O14 compound treatment 4.2080595E7 -5.85E7 -3.34 4.2039588E7 -6.07E7 -3.74 -5.0109 -0.9984 3059431 SPBio_001572 CCC(=O)O[C@H]1CCC2C3CCc4cc(O)ccc4C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O15 compound treatment 8.1529102E7 -1.9E7 -1.09 9.0736691E7 -1.2E7 -0.74 -1.2941 -0.9825 2060475 SPBio_001573 COc1cc(OC)c2C(=O)CC(Oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O16 compound treatment 8.2263966E7 -1.83E7 -1.05 8.8534881E7 -1.42E7 -0.88 -1.3603 -0.9962 813 SPBio_001574 CC(=O)O[C@H]1CCC2C3CCc4cc(OC(=O)C)ccc4C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O17 compound treatment 9.5822863E7 -4750000.0 -0.27 1.03972774E8 1210000.0 0.07 -0.1395 -0.4954 2060277 SPBio_001575 COc1cccc2c(=O)c(OC)c(oc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O18 compound treatment 8.8350121E7 -1.22E7 -0.7 8.7874692E7 -1.49E7 -0.92 -1.1432 -0.9909 3177458 SPBio_001576 CC(=O)Oc1ccc2C3CC[C@@]4(C)C(CCC4=O)C3CCc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O19 compound treatment 8.3432134E7 -1.71E7 -0.98 8.5913115E7 -1.69E7 -1.04 -1.4274 -0.9996 1554635 SPBio_001577 COc1cc(OC)c2c(=O)cc(oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O20 compound treatment 5.4027898E7 -4.65E7 -2.66 4.9047279E7 -5.37E7 -3.31 -4.2226 -0.9941 773 SPBio_001578 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O21 compound treatment 9.5656846E7 -4920000.0 -0.28 1.00728185E8 -2040000.0 -0.13 -0.2876 -0.9342 724 SPBio_001579 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O22 compound treatment 3.2877565E7 -6.77E7 -3.87 3.3347404E7 -6.94E7 -4.28 -5.7617 -0.9987 782 SPBio_001580 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=CC5(C)C4C(O)CC3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O23 mock treatment 9.7027842E7 -3550000.0 -0.2 9.6780181E7 -5990000.0 -0.37 -0.4043 -0.9602 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 O24 mock treatment 1.0795742E8 7380000.0 0.42 1.07810033E8 5040000.0 0.31 0.5182 0.9887 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P01 mock treatment 1.10570031E8 1.0E7 0.57 1.17800794E8 1.5E7 0.93 1.0592 0.973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P02 mock treatment 1.04688084E8 4110000.0 0.24 1.09505993E8 6740000.0 0.42 0.46 0.9637 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P03 compound treatment 1.01830469E8 1260000.0 0.07 1.06897012E8 4130000.0 0.25 0.2308 0.8724 1255 SPBio_001581 NC(=O)c1ccc(cc1Cl)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P04 compound treatment 1.01833364E8 1260000.0 0.07 1.07779896E8 5010000.0 0.31 0.2694 0.849 1419 SPBio_001582 NCCSSCCN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P05 compound treatment 8.1238257E7 -1.93E7 -1.11 8.5706747E7 -1.71E7 -1.05 -1.5251 -0.9997 1263 SPBio_001583 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P06 compound treatment 8.6681426E7 -1.39E7 -0.79 1.01808142E8 -959000.0 -0.06 -0.6033 -0.7576 1524 SPBio_001584 CC(C)Nc1c(C)n(C)n(c2ccccc2)c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P07 compound treatment 8.2478464E7 -1.81E7 -1.03 1.00822572E8 -1940000.0 -0.12 -0.8161 -0.7838 1424 SPBio_001585 CCCC(=O)Nc1ncnc2n(cnc12)C3O[C@@H]4COP(=O)(O)O[C@H]4[C@H]3OC(=O)CCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P08 compound treatment 8.0998458E7 -1.96E7 -1.12 1.01208256E8 -1560000.0 -0.1 -0.8591 -0.765 1452 SPBio_001586 CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P09 compound treatment 8.8419928E7 -1.22E7 -0.69 9.9634619E7 -3130000.0 -0.19 -0.6277 -0.8706 1246 SPBio_001587 CC[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P10 compound treatment 3.0922551E7 -6.97E7 -3.98 3.3021833E7 -6.97E7 -4.3 -5.8549 -0.9993 1493 SPBio_001588 CCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P11 compound treatment 8.7352109E7 -1.32E7 -0.76 1.01181519E8 -1590000.0 -0.1 -0.6035 -0.792 1299 SPBio_001589 Nc1ccc(cc1)C(=O)NCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P12 compound treatment 3.2839746E7 -6.77E7 -3.87 3.5061167E7 -6.77E7 -4.17 -5.6885 -0.9993 1526 SPBio_001590 CC1CCCC(C)N1NC(=O)c2ccc(Cl)c(c2)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P13 compound treatment 2.8952443E7 -7.16E7 -4.09 2.9121881E7 -7.36E7 -4.54 -6.1045 -0.9987 1387 SPBio_001591 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P14 compound treatment 3.9978481E7 -6.06E7 -3.46 3.9523729E7 -6.32E7 -3.9 -5.2055 -0.9983 1431 SPBio_001592 Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P15 compound treatment 7.4009189E7 -2.66E7 -1.52 7.8495256E7 -2.43E7 -1.5 -2.1315 -1.0 872 SPBio_001593 CCN(CC)CCOC(=O)C(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P16 compound treatment 8.6514878E7 -1.41E7 -0.8 8.7856071E7 -1.49E7 -0.92 -1.2181 -0.9978 3045655 SPBio_001594 CC(=O)[C@@]1(O)CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5CC5[C@]4(C)C3CC[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P17 compound treatment 8.6844867E7 -1.37E7 -0.78 9.6163305E7 -6600000.0 -0.41 -0.8427 -0.9533 701 SPBio_001595 Nc1c(Br)cc(Br)cc1CNC2CCC(O)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P18 compound treatment 8.894333E7 -1.16E7 -0.66 9.3314099E7 -9450000.0 -0.58 -0.8821 -0.9978 3172846 SPBio_001596 NC(CO)(CO)CO.OC(=O)C1CCn2c(ccc12)C(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P19 compound treatment 9.4063975E7 -6510000.0 -0.37 1.00038944E8 -2730000.0 -0.17 -0.382 -0.9356 3174106 SPBio_001597 CN(C)CCCO[C@H]1[C@H](OC2OC(C)(C)O[C@H]12)C(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P20 compound treatment 8.8188369E7 -1.24E7 -0.71 9.5129361E7 -7640000.0 -0.47 -0.8335 -0.9804 1453 SPBio_001598 CN1CCCN=C1/C=C/c2sccc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P21 compound treatment 5.0850456E7 -4.97E7 -2.84 5.378291E7 -4.9E7 -3.02 -4.1446 -0.9995 818 SPBio_001599 CCC1(CC)C(=O)NC=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P22 compound treatment 9.4513312E7 -6060000.0 -0.35 9.4887429E7 -7880000.0 -0.49 -0.5884 -0.9863 1461 SPBio_001600 CN1CCCN=C1COC(=O)C(O)(C2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P23 mock treatment 1.04031542E8 3460000.0 0.2 1.06967064E8 4200000.0 0.26 0.3228 0.9911 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2162 P24 mock treatment 1.11344156E8 1.08E7 0.62 1.14836936E8 1.21E7 0.74 0.9613 0.9956 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A01 mock treatment 1.21686496E8 1.95E7 1.11 1.29263333E8 2.5E7 1.54 1.8785 0.9872 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A02 mock treatment 1.02367028E8 171000.0 0.01 1.17756175E8 1.35E7 0.83 0.5962 0.7154 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A03 compound treatment 8.2227044E7 -2.0E7 -1.14 1.13516058E8 9280000.0 0.57 -0.4025 -0.3153 3045683 SPBio_001601 C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A04 compound treatment 4.1375488E7 -6.08E7 -3.48 4.1472762E7 -6.28E7 -3.87 -5.1937 -0.9986 3177591 SPBio_001602 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](OC(=O)C)c4cc5OCOc5cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A05 compound treatment 2.8867022E7 -7.33E7 -4.19 2.8675644E7 -7.56E7 -4.66 -6.257 -0.9986 1465 SPBio_001603 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A06 compound treatment 9.4210208E7 -7990000.0 -0.46 9.7392518E7 -6840000.0 -0.42 -0.6211 -0.9992 2475 SPBio_001604 CC(=CC1C(C(=O)O)C1(C)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A07 compound treatment 7.1944199E7 -3.03E7 -1.73 8.5252259E7 -1.9E7 -1.17 -2.0501 -0.9819 1489 SPBio_001605 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A08 compound treatment 7.1926613E7 -3.03E7 -1.73 8.9774399E7 -1.45E7 -0.89 -1.8537 -0.9525 1013144 SPBio_001606 O=C1OC(=O)C2C3CCC(O3)C21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A09 compound treatment 6.7451125E7 -3.47E7 -1.99 9.026395E7 -1.4E7 -0.86 -2.0132 -0.9301 1459 SPBio_001607 OC1CCN(CCCN2c3ccccc3Sc4ccc(C#N)cc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A10 compound treatment 8.1521829E7 -2.07E7 -1.18 9.3894304E7 -1.03E7 -0.64 -1.2863 -0.9581 3059791 SPBio_001608 Nc1nc(cs1)/C(=C/CC(=O)O)/C(=O)N[C@H]2[C@H]3SCC=C(N3C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A11 compound treatment 8.1546874E7 -2.06E7 -1.18 9.0672416E7 -1.36E7 -0.84 -1.4257 -0.9858 1495 SPBio_001609 OC(=O)CCCCC1CCSS1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A12 compound treatment 8.1817306E7 -2.04E7 -1.16 8.7839333E7 -1.64E7 -1.01 -1.5383 -0.9975 3059465 SPBio_001610 Nc1nc(cs1)/C(=N/O)/C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A13 compound treatment 7.5062574E7 -2.71E7 -1.55 8.6249871E7 -1.8E7 -1.11 -1.8806 -0.9865 1317 SPBio_001611 Fc1ccc(cc1)C(c2ccccc2)(c3ccccc3F)n4ccnc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A14 compound treatment 5.9903816E7 -4.23E7 -2.42 5.5572454E7 -4.87E7 -3.0 -3.8303 -0.9943 3480112 SPBio_001612 CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A15 compound treatment 8.2110349E7 -2.01E7 -1.15 7.984671E7 -2.44E7 -1.5 -1.8748 -0.9911 1605 SPBio_001613 OC(Cn1cncn1)(Cn2cncn2)c3ccc(F)cc3F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A16 compound treatment 8.7606308E7 -1.46E7 -0.83 8.7295277E7 -1.69E7 -1.04 -1.3281 -0.9938 3079224 SPBio_001614 COC1=C(O)C(=O)c2c(O)c3c(O)c(oc3cc2C1=O)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A17 compound treatment 7.6894897E7 -2.53E7 -1.45 8.9824957E7 -1.44E7 -0.89 -1.6507 -0.9726 839435 SPBio_001615 NCCCCNC(=N)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A18 compound treatment 1.19545635E8 1.73E7 0.99 1.00090032E8 -4150000.0 -0.26 0.5204 0.5082 3079225 SPBio_001616 OC(=O)CCC1NCC2CC1CN3CCCCC23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A19 compound treatment 9.8059322E7 -4140000.0 -0.24 9.4620816E7 -9620000.0 -0.59 -0.5863 -0.9187 3250 SPBio_001617 CCCCCCCCCCCCCCCCCCOCC(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A20 compound treatment 1.05946285E8 3750000.0 0.21 9.6362095E7 -7880000.0 -0.49 -0.1917 -0.3613 1592184 SPBio_001618 O=C1CCCC2C3CC(CN21)[C@@H]4CCCCN4C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A21 compound treatment 1.02274585E8 78600.0 0.0 1.08314112E8 4080000.0 0.25 0.1809 0.7196 1537011 SPBio_001619 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A22 compound treatment 1.04256561E8 2060000.0 0.12 1.0849408E8 4260000.0 0.26 0.2688 0.9346 3079226 SPBio_001620 C1CN2Cc3ccccc3N=C2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A23 mock treatment 1.08434346E8 6240000.0 0.36 1.10254725E8 6020000.0 0.37 0.5144 0.9998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 A24 mock treatment 1.18674652E8 1.65E7 0.94 1.20563568E8 1.63E7 1.01 1.3776 0.9995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B01 mock treatment 1.37270761E8 3.51E7 2.0 1.26593881E8 2.24E7 1.38 2.3919 0.9833 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B02 mock treatment 1.08861559E8 6670000.0 0.38 1.05715975E8 1480000.0 0.09 0.3338 0.8522 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B03 compound treatment 5.336688E7 -4.88E7 -2.79 5.2044727E7 -5.22E7 -3.22 -4.2483 -0.9975 2060222 SPBio_001621 C/C/1=C\CCC(=O)C2CC(C)(C)C2CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B04 compound treatment 9.4146025E7 -8050000.0 -0.46 9.7910905E7 -6330000.0 -0.39 -0.6011 -0.9966 2515 SPBio_001622 CCCCCCC(C)OC(=O)COc1cc(Cl)c(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B05 compound treatment 1.01856887E8 -339000.0 -0.02 1.01992088E8 -2250000.0 -0.14 -0.1116 -0.7983 1099943 SPBio_001623 COc1c2C=CC(C)(C)Oc2c(CC=C(C)C)c3oc(=O)c(c(O)c13)c4ccc(O)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B06 compound treatment 2.7874752E7 -7.43E7 -4.25 2.7824616E7 -7.64E7 -4.71 -6.3342 -0.9987 2517 SPBio_001624 CC(C)N(C(=O)CCl)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B07 compound treatment 9.8152963E7 -4040000.0 -0.23 8.93057E7 -1.49E7 -0.92 -0.8142 -0.858 2060382 SPBio_001625 C/C/1=C\CC(C)(C)\C=C\CC2(C)OC2CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B08 compound treatment 1.08912369E8 6720000.0 0.38 1.04492902E8 256000.0 0.02 0.2826 0.7355 2518 SPBio_001626 CCCCSP(=O)(SCCCC)SCCCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B09 compound treatment 8.2434909E7 -1.98E7 -1.13 8.773771E7 -1.65E7 -1.02 -1.5178 -0.9986 1981222 SPBio_001627 CCN1CCN(C(=O)NC(C(=O)NC2C3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4C)c5ccc(O)cc5)C(=O)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B10 compound treatment 8.8913577E7 -1.33E7 -0.76 8.4067241E7 -2.02E7 -1.24 -1.4159 -0.972 2519 SPBio_001628 CC(C)N(C(C)C)C(=O)SCC(=C(Cl)Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B11 compound treatment 7.6288884E7 -2.59E7 -1.48 7.7396386E7 -2.68E7 -1.65 -2.2169 -0.9985 3174236 SPBio_001629 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cc(cc34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B12 compound treatment 8.7563725E7 -1.46E7 -0.84 7.9757463E7 -2.45E7 -1.51 -1.6583 -0.9612 2479 SPBio_001630 CCOP(=S)(OCC)Oc1ccc2c(C)c(Cl)c(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B13 compound treatment 7.6281475E7 -2.59E7 -1.48 7.7266052E7 -2.7E7 -1.66 -2.2229 -0.9983 2060221 SPBio_001631 COc1ccc(cc1)[C@H]2Oc3cc(OC)cc(OC)c3C[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B14 compound treatment 7.3583083E7 -2.86E7 -1.64 7.4332438E7 -2.99E7 -1.84 -2.4598 -0.9982 2480 SPBio_001632 COP(=S)(OC)SCn1nnc2ccccc2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B15 compound treatment 5.5174741E7 -4.7E7 -2.69 6.2287248E7 -4.19E7 -2.59 -3.7287 -0.9998 2060258 SPBio_001633 CC(=O)O[C@H]1Cc2c(OC(=O)C)cc(OC(=O)C)cc2O[C@@H]1c3ccc(OC(=O)C)c(OC(=O)C)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B16 compound treatment 7.6668049E7 -2.55E7 -1.46 7.8097383E7 -2.61E7 -1.61 -2.171 -0.9988 2513 SPBio_001634 OC(=O)CNCP(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B17 compound treatment 7.9963447E7 -2.22E7 -1.27 8.2988554E7 -2.12E7 -1.31 -1.8246 -0.9999 2060256 SPBio_001635 CC(=CC1C(CO)C1(C)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B18 compound treatment 8.0597299E7 -2.16E7 -1.23 8.1907625E7 -2.23E7 -1.38 -1.8461 -0.9985 2514 SPBio_001636 CCCCCCC(C)OC(=O)COc1ccc(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B19 compound treatment 8.5751053E7 -1.64E7 -0.94 8.7324394E7 -1.69E7 -1.04 -1.4018 -0.9987 1952709 SPBio_001637 COc1ccc2c(C)cc(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B20 compound treatment 1.02845114E8 649000.0 0.04 9.756035E7 -6680000.0 -0.41 -0.2648 -0.6408 2478 SPBio_001638 COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B21 compound treatment 9.4777467E7 -7420000.0 -0.42 9.53204E7 -8920000.0 -0.55 -0.6885 -0.9918 1000110 SPBio_001639 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B22 compound treatment 9.1047585E7 -1.11E7 -0.64 9.8901328E7 -5340000.0 -0.33 -0.6831 -0.9527 2512 SPBio_001640 COC(=O)COc1cc(Cl)c(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B23 mock treatment 9.8768926E7 -3430000.0 -0.2 9.8310921E7 -5930000.0 -0.37 -0.3968 -0.9573 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 B24 mock treatment 1.12373443E8 1.02E7 0.58 1.16204399E8 1.2E7 0.74 0.9329 0.9931 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C01 mock treatment 1.00913475E8 -1280000.0 -0.07 1.11247494E8 7010000.0 0.43 0.2537 0.5789 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C02 mock treatment 8.5837211E7 -1.64E7 -0.93 1.03213393E8 -1020000.0 -0.06 -0.7057 -0.7531 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C03 compound treatment 7.0605298E7 -3.16E7 -1.81 1.05224818E8 988000.0 0.06 -1.2336 -0.6829 3172723 SPBio_001641 CC(=O)OC[C@@]1(O)C[C@@]2(C[C@H]1CCC23)CCC4c5ccoc5CC[C@@]43C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C04 compound treatment 8.6939373E7 -1.53E7 -0.87 9.4267047E7 -9970000.0 -0.61 -1.0511 -0.9853 3198437 SPBio_001642 C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OC[C@H]1OC([C@H](O)[C@@H]1O)n2ccc(N)nc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C05 compound treatment 5.7236614E7 -4.5E7 -2.57 7.0699609E7 -3.35E7 -2.07 -3.2787 -0.9942 1978 SPBio_001643 OC(=O)/C=C/c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C06 compound treatment 8.7906578E7 -1.43E7 -0.82 9.1957465E7 -1.23E7 -0.76 -1.1127 -0.9993 3079227 SPBio_001644 [O-][N+](=O)/N=C/1\NCCN1Cc2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C07 compound treatment 8.3165449E7 -1.9E7 -1.09 8.7966771E7 -1.63E7 -1.0 -1.4783 -0.9992 2060330 SPBio_001645 OC[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C08 compound treatment 7.2892425E7 -2.93E7 -1.67 8.7006173E7 -1.72E7 -1.06 -1.9353 -0.9759 3079228 SPBio_001646 CCNC(=O)CC[C@H](N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C09 compound treatment 6.3445962E7 -3.87E7 -2.21 7.6444464E7 -2.78E7 -1.71 -2.7774 -0.992 2060332 SPBio_001647 OC/C=C/c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C10 compound treatment 6.9507335E7 -3.27E7 -1.87 8.3402241E7 -2.08E7 -1.28 -2.2292 -0.9833 3076175 SPBio_001648 COc1cc(ccc1O)[C@H]2Oc3cc(ccc3O[C@@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C11 compound treatment 8.6386839E7 -1.58E7 -0.9 8.7945231E7 -1.63E7 -1.0 -1.349 -0.9986 907149 SPBio_001649 CN(C)c1nc(N)c(nc1Cl)C(=O)NC(=N)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C12 compound treatment 7.80213E7 -2.42E7 -1.38 7.7935257E7 -2.63E7 -1.62 -2.1234 -0.9968 3198531 SPBio_001650 COc1ccc(cc1)c2oc3c(CC=C(C)C)c(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc(O)c3c(=O)c2O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C13 compound treatment 8.0109708E7 -2.21E7 -1.26 7.7509672E7 -2.67E7 -1.65 -2.0576 -0.9913 1316 SPBio_001651 CC(C)(C)NCC(O)c1ccccc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C14 compound treatment 7.9885319E7 -2.23E7 -1.28 7.4539289E7 -2.97E7 -1.83 -2.1961 -0.9844 1672 SPBio_001652 OC(=O)CCc1nc(c(o1)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C15 compound treatment 4.2440667E7 -5.98E7 -3.42 4.6042837E7 -5.82E7 -3.59 -4.9514 -0.9997 2060337 SPBio_001653 COc1ccc(cc1O)c2oc3cc(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(O)c3c(=O)c2OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C16 compound treatment 6.5456438E7 -3.67E7 -2.1 6.5157378E7 -3.91E7 -2.41 -3.1881 -0.9977 1045397 SPBio_001654 COc1ccc(cc1OC)c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C17 compound treatment 4.4469661E7 -5.77E7 -3.3 6.1389286E7 -4.28E7 -2.64 -4.2005 -0.9939 2060338 SPBio_001655 CC(C)c1ccc2c(CC[C@H]3C4=C(CC[C@@]32C)C(=O)OC4)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C18 compound treatment 7.5544215E7 -2.67E7 -1.52 7.0050799E7 -3.42E7 -2.11 -2.5672 -0.9873 1034727 SPBio_001656 COc1ccc(cc1)c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C19 compound treatment 8.3303354E7 -1.89E7 -1.08 8.1463992E7 -2.28E7 -1.4 -1.7561 -0.9916 2060340 SPBio_001657 CC(=O)/C(=C\c1ccccc1)/CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C20 compound treatment 8.1265156E7 -2.09E7 -1.2 8.3075612E7 -2.12E7 -1.3 -1.7682 -0.9991 351 SPBio_001658 CC(C)NCC(O)COc1cccc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C21 compound treatment 5.4265912E7 -4.79E7 -2.74 6.1403896E7 -4.28E7 -2.64 -3.804 -0.9998 1020994 SPBio_001659 COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C22 compound treatment 9.5966713E7 -6230000.0 -0.36 9.5153359E7 -9080000.0 -0.56 -0.6477 -0.9761 2660 SPBio_001660 CCN(C(=O)/C=C/C)c1ccccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C23 mock treatment 8.7228335E7 -1.5E7 -0.86 9.335881E7 -1.09E7 -0.67 -1.079 -0.9927 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 C24 mock treatment 1.11292347E8 9100000.0 0.52 1.14628181E8 1.04E7 0.64 0.8205 0.9946 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D01 mock treatment 1.11900572E8 9700000.0 0.55 1.06250122E8 2010000.0 0.12 0.4799 0.8444 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D02 mock treatment 1.01507392E8 -689000.0 -0.04 9.7228745E7 -7010000.0 -0.43 -0.3333 -0.7683 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D03 compound treatment 1.12659596E8 1.05E7 0.6 1.05066179E8 829000.0 0.05 0.459 0.7647 2060195 SPBio_001661 CC1(C)CC23C1CCC3(C)C(O)CCC2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D04 compound treatment 1.11404457E8 9210000.0 0.53 1.01177262E8 -3060000.0 -0.19 0.2388 0.4271 2510 SPBio_001662 COC(=O)COc1ccc(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D05 compound treatment 1.07293842E8 5100000.0 0.29 9.6783691E7 -7450000.0 -0.46 -0.1189 -0.2185 2060197 SPBio_001663 COC1(C)CCC2OC2(C)CCC3C1CC3(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D06 compound treatment 1.05240944E8 3040000.0 0.17 9.7863416E7 -6370000.0 -0.39 -0.1548 -0.3602 2511 SPBio_001664 COC(=O)CCCOc1ccc(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D07 compound treatment 1.05445371E8 3250000.0 0.19 8.9321304E7 -1.49E7 -0.92 -0.5188 -0.5531 2069257 SPBio_001665 CC1(C)CC2C1CCC(=C)C(O)CCC2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D08 compound treatment 3.4223527E7 -6.8E7 -3.88 3.4252733E7 -7.0E7 -4.31 -5.7974 -0.9986 2509 SPBio_001666 CCc1cccc(CC)c1N(COC)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D09 compound treatment 9.9111152E7 -3080000.0 -0.18 8.759101E7 -1.66E7 -1.03 -0.8502 -0.8166 2060199 SPBio_001667 CC1(C)CC2C1CCC3(C)OC2(C)CCC3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D10 compound treatment 9.970373E7 -2490000.0 -0.14 8.4824461E7 -1.94E7 -1.2 -0.9469 -0.7857 2507 SPBio_001668 OC(=O)CCCOc1ccc(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D11 compound treatment 9.73919E7 -4800000.0 -0.27 8.3084349E7 -2.12E7 -1.3 -1.1162 -0.8376 2060200 SPBio_001669 CC12CCC3C(CC3(C)C)C(C)(O)CCC2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D12 compound treatment 9.5892533E7 -6300000.0 -0.36 7.6910503E7 -2.73E7 -1.68 -1.4458 -0.8394 2506 SPBio_001670 OC(=O)COc1ccc(Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D13 compound treatment 9.0831007E7 -1.14E7 -0.65 8.1564466E7 -2.27E7 -1.4 -1.4475 -0.9393 2060202 SPBio_001671 CC1(C)CC2C1CCC3(C)OC2(C)CCC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D14 compound treatment 8.3825202E7 -1.84E7 -1.05 7.4815582E7 -2.94E7 -1.81 -2.0248 -0.9662 2481 SPBio_001672 CCOP(=S)(OCC)SCCSCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D15 compound treatment 7.9213268E7 -2.3E7 -1.31 6.3028829E7 -4.12E7 -2.54 -2.725 -0.9529 2060204 SPBio_001673 CC(=O)OC1CC(C)(C)C2CCC3(C)CC12CCC3OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D16 compound treatment 8.9042193E7 -1.32E7 -0.75 8.5191564E7 -1.9E7 -1.17 -1.3617 -0.9768 2482 SPBio_001674 CCOC(=O)/C=C(\C)/OP(=O)(OC)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D17 compound treatment 8.3185501E7 -1.9E7 -1.09 7.7680417E7 -2.66E7 -1.64 -1.9258 -0.9802 2060219 SPBio_001675 CC(=O)OC/1CCC(=C)[C@H]2CC(C)(C)[C@@H]2C\C=C1/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D18 compound treatment 9.3764645E7 -8430000.0 -0.48 8.7530432E7 -1.67E7 -1.03 -1.0689 -0.9401 2483 SPBio_001676 COP(=O)(OC)OC(Br)C(Cl)(Cl)Br 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D19 compound treatment 9.2182152E7 -1.0E7 -0.57 8.465142E7 -1.96E7 -1.21 -1.2584 -0.9418 2060264 SPBio_001677 C[C@@H]1CC[C@]2(CCC3(C)[C@]4(OC2=O)C=CC5[C@@]6(C)CC[C@H](O)C(C)(C)C6CC[C@]53C)C4[C@H]1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D20 compound treatment 8.9938311E7 -1.23E7 -0.7 9.0059325E7 -1.42E7 -0.87 -1.1133 -0.994 2485 SPBio_001678 CCS(=O)CCSP(=O)(OC)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D21 compound treatment 7.6545248E7 -2.57E7 -1.47 7.7484256E7 -2.68E7 -1.65 -2.2027 -0.9983 2060266 SPBio_001679 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC(=O)C4[C@@]5(C)CC[C@H](OC(=O)C)C(C)(C)C5CC[C@]43C)C2[C@H]1C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D22 compound treatment 9.1010442E7 -1.12E7 -0.64 8.7612952E7 -1.66E7 -1.02 -1.1766 -0.9742 2490 SPBio_001680 CCOP(=S)(OCC)SCSCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D23 mock treatment 8.8628255E7 -1.36E7 -0.78 9.718169E7 -7060000.0 -0.43 -0.8558 -0.9626 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 D24 mock treatment 1.01686161E8 -510000.0 -0.03 1.02673836E8 -1560000.0 -0.1 -0.0887 -0.8815 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E01 mock treatment 1.01120006E8 -1080000.0 -0.06 1.02973204E8 -1260000.0 -0.08 -0.0986 -0.9931 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E02 mock treatment 9.6195297E7 -6000000.0 -0.34 9.9124005E7 -5110000.0 -0.32 -0.4654 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E03 compound treatment 6.9390876E7 -3.28E7 -1.87 1.06769254E8 2530000.0 0.16 -1.2154 -0.646 3172852 SPBio_001681 CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)C5CC[C@]43C)C2C1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E04 compound treatment 9.1119254E7 -1.11E7 -0.63 1.03042248E8 -1190000.0 -0.07 -0.4997 -0.7841 3079229 SPBio_001682 CC1(C)C2CC(O)C(C)(O)CC21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E05 compound treatment 4.1907067E7 -6.03E7 -3.45 2.9864836E7 -7.44E7 -4.58 -5.6781 -0.9901 3172853 SPBio_001683 C[C@@H]1OC(O[C@@H]2[C@@H](O)[C@@H](O)COC2O[C@H]3CC[C@@]4(C)C(CC[C@]5(C)C4CC=C6C7CC(C)(C)CC[C@@]7(CC[C@]65C)C(=O)O)[C@]3(C)CO)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E06 compound treatment 5.4202357E7 -4.8E7 -2.74 5.3623783E7 -5.06E7 -3.12 -4.1457 -0.9979 1053060 SPBio_001684 COc1ccc(cc1OC)c2oc3ccccc3c(=O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E07 compound treatment 8.5271744E7 -1.69E7 -0.97 9.1555153E7 -1.27E7 -0.78 -1.2367 -0.9944 2060345 SPBio_001685 C[C@@H]1OC(O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC(=O)[C@@]45CCC(C)(C)CC5C6=CCC7[C@@]8(C)CC[C@H](OC9OC[C@H](O)[C@H](O)[C@H]9OC%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@@](C)(CO)C8CC[C@@]7(C)[C@]6(C)CC4)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E08 compound treatment 8.115052E7 -2.1E7 -1.2 8.9507653E7 -1.47E7 -0.91 -1.4925 -0.9904 1864491 SPBio_001686 COc1ccc(cc1)c2coc3cc(OC)cc(OC)c3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E09 compound treatment 3.2205043E7 -7.0E7 -4.0 3.6337346E7 -6.79E7 -4.19 -5.7881 -0.9997 829 SPBio_001687 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E10 compound treatment 5.6835929E7 -4.54E7 -2.59 6.1529392E7 -4.27E7 -2.63 -3.6946 -1.0 3198532 SPBio_001688 COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E11 compound treatment 8.0118156E7 -2.21E7 -1.26 7.9997196E7 -2.42E7 -1.49 -1.9488 -0.9965 1054504 SPBio_001689 COc1c(OCC(O)C(C)(C)O)ccc2c(OC)c3ccoc3nc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E12 compound treatment 7.0955627E7 -3.12E7 -1.79 6.9147183E7 -3.51E7 -2.16 -2.792 -0.9955 435 SPBio_001690 CC(C)Cn1c(=O)n(C)c(=O)c2nc[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E13 compound treatment 8.3612506E7 -1.86E7 -1.06 8.3812445E7 -2.04E7 -1.26 -1.6413 -0.9964 1024517 SPBio_001691 COc1cc2CCNC(C)c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E14 compound treatment 8.0730891E7 -2.15E7 -1.23 7.641421E7 -2.78E7 -1.72 -2.0802 -0.9865 832325 SPBio_001692 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E15 compound treatment 8.2933307E7 -1.93E7 -1.1 7.4312741E7 -2.99E7 -1.84 -2.0828 -0.9696 3079221 SPBio_001693 O=c1cccc2C3CC(Cn21)[C@@H]4CCCCN4C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E16 compound treatment 8.8149759E7 -1.4E7 -0.8 8.1335063E7 -2.29E7 -1.41 -1.5659 -0.9642 1099044 SPBio_001694 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2cncn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E17 compound treatment 9.530141E7 -6890000.0 -0.39 8.394347E7 -2.03E7 -1.25 -1.1632 -0.8869 2060358 SPBio_001695 C[C@@H]1CCC2[C@](C)(CO)[C@@H](O)CC[C@]2(C)[C@]31CC[C@@](CO)(CCO)O3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E18 compound treatment 1.02596865E8 401000.0 0.02 9.0328082E7 -1.39E7 -0.86 -0.5901 -0.688 3198533 SPBio_001696 CCc1c(C)c2=Cc3c(C=C)c(C)c4C=c5c(C)c(CCC(=O)O)c6=C7C(C(=O)O)C(=O)c8c(C)c9C=c1n2[Cu](n9c78)(n43)n56 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E19 compound treatment 7.9945113E7 -2.23E7 -1.27 7.5249802E7 -2.9E7 -1.79 -2.1627 -0.9861 2060328 SPBio_001697 CC(C)CC(=O)c1c(O)c(C)c(O)c2c1oc3c(C(=O)CC(C)C)c(O)c(C)c(O)c32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E20 compound treatment 7.0518022E7 -3.17E7 -1.81 6.6529073E7 -3.77E7 -2.32 -2.9238 -0.9924 1017318 SPBio_001698 NC(=O)c1ccc(N)nc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E21 compound treatment 8.4815667E7 -1.74E7 -0.99 8.1758289E7 -2.25E7 -1.39 -1.6822 -0.9867 2060307 SPBio_001699 COc1ccc2[C@@H](O)[C@H](Cc3ccc(OC)c(OC)c3)COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E22 compound treatment 8.3096274E7 -1.91E7 -1.09 8.2570785E7 -2.17E7 -1.34 -1.7163 -0.995 2109 SPBio_001700 OCc1c[nH]c2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E23 mock treatment 9.0099767E7 -1.21E7 -0.69 9.3351184E7 -1.09E7 -0.67 -0.9633 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 E24 mock treatment 1.03789447E8 1590000.0 0.09 1.00139023E8 -4100000.0 -0.25 -0.1142 -0.4254 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F01 mock treatment 1.00582971E8 -1610000.0 -0.09 1.06308541E8 2070000.0 0.13 0.0251 0.1594 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F02 mock treatment 1.12488316E8 1.03E7 0.59 1.05622619E8 1390000.0 0.09 0.4763 0.8014 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F03 compound treatment 1.11597927E8 9400000.0 0.54 1.04536786E8 300000.0 0.02 0.393 0.731 2060268 SPBio_001701 C[C@@H]1CC[C@]2(CCC3(C)[C@]4(OC2=O)C=CC5[C@@]6(C)CCC(=O)C(C)(C)C6CC[C@]53C)C4[C@H]1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F04 compound treatment 1.05340663E8 3140000.0 0.18 9.9579552E7 -4660000.0 -0.29 -0.0759 -0.2242 2486 SPBio_001702 CNC(=O)CSP(=S)(OC)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F05 compound treatment 5.4888806E7 -4.73E7 -2.7 5.975293E7 -4.45E7 -2.74 -3.8508 -1.0 2060270 SPBio_001703 CC(C)c1ccc2c(CCC3C(C)(CCCC32C)C(=O)N)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F06 compound treatment 7.9629903E7 -2.26E7 -1.29 7.6763779E7 -2.75E7 -1.69 -2.1095 -0.991 2488 SPBio_001704 CCOP(=S)(OCC)SCn1c(=O)oc2cc(Cl)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F07 compound treatment 1.00888765E8 -1310000.0 -0.07 9.4903907E7 -9330000.0 -0.58 -0.4596 -0.7923 2060272 SPBio_001705 CC1CCC2C(CC2(C)C)C(=C)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F08 compound treatment 9.8487264E7 -3710000.0 -0.21 9.1969781E7 -1.23E7 -0.76 -0.6846 -0.8717 2489 SPBio_001706 COP(=O)(N)SC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F09 compound treatment 7.5875796E7 -2.63E7 -1.5 6.3570874E7 -4.07E7 -2.51 -2.8362 -0.9702 2060274 SPBio_001707 CC(C)C1CC=C(C)C2CC(=O)C(=CC12)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F10 compound treatment 8.8803562E7 -1.34E7 -0.77 8.0108035E7 -2.41E7 -1.49 -1.593 -0.9523 3046265 SPBio_001708 Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F11 compound treatment 9.1850066E7 -1.03E7 -0.59 8.609274E7 -1.81E7 -1.12 -1.209 -0.9556 3053888 SPBio_001709 CC(=CCC[C@](C)(OC(=O)C)C1CCC(=CC1)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F12 compound treatment 8.8027641E7 -1.42E7 -0.81 8.2304369E7 -2.19E7 -1.35 -1.5286 -0.9699 2534 SPBio_001710 ClC(=C(c1ccc(Cl)cc1)c2ccc(Cl)cc2)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F13 compound treatment 8.0439881E7 -2.18E7 -1.24 5.6458197E7 -4.78E7 -2.95 -2.9618 -0.9265 3053889 SPBio_001711 C[C@@H]1CC[C@H]2C(C)(C)C3CC12CC[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F14 compound treatment 8.0046829E7 -2.21E7 -1.27 7.2343051E7 -3.19E7 -1.97 -2.2853 -0.9773 1304 SPBio_001712 ClC1=C(Cl)C2(Cl)C3C4CC(C5OC54)C3C1(Cl)C2(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F15 compound treatment 8.7114599E7 -1.51E7 -0.86 7.8995554E7 -2.52E7 -1.56 -1.7097 -0.9612 2069281 SPBio_001713 C[C@@]12CCC3C(CCc4cc(OC(=O)c5ccccc5)ccc34)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F16 compound treatment 5.9020917E7 -4.32E7 -2.47 4.744337E7 -5.68E7 -3.5 -4.2203 -0.9853 2535 SPBio_001714 CC1(C)C(C(Cl)Cl)C2(Cl)C(Cl)C(Cl)C1(Cl)C2(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F17 compound treatment 8.965169E7 -1.25E7 -0.72 8.5057544E7 -1.92E7 -1.18 -1.3429 -0.9713 3053891 SPBio_001715 OC(=O)C/C(=C\C(=O)O)/C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F18 compound treatment 9.1431755E7 -1.08E7 -0.62 9.1861852E7 -1.24E7 -0.76 -0.9744 -0.9943 2536 SPBio_001716 ClC1CC2C(C1Cl)C3(Cl)C(Cl)C(Cl)C2(Cl)C3(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F19 compound treatment 9.4002196E7 -8190000.0 -0.47 9.3434478E7 -1.08E7 -0.67 -0.802 -0.9852 1045072 SPBio_001717 NC(CSCSCC(N)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F20 compound treatment 9.3818908E7 -8380000.0 -0.48 9.4750399E7 -9490000.0 -0.58 -0.752 -0.9951 2520 SPBio_001718 Clc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F21 compound treatment 9.5520534E7 -6680000.0 -0.38 9.1901277E7 -1.23E7 -0.76 -0.8075 -0.9491 3054971 SPBio_001719 O[C@@H]1C[C@](O)(C[C@@H](O)[C@@H]1O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F22 compound treatment 7.2132192E7 -3.01E7 -1.72 7.9038295E7 -2.52E7 -1.55 -2.3133 -0.9987 2521 SPBio_001720 Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F23 mock treatment 8.6928921E7 -1.53E7 -0.87 8.9097989E7 -1.51E7 -0.93 -1.2769 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 F24 mock treatment 9.5059919E7 -7140000.0 -0.41 9.9108421E7 -5130000.0 -0.32 -0.5119 -0.9921 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G01 mock treatment 9.4958058E7 -7240000.0 -0.41 1.00836855E8 -3400000.0 -0.21 -0.4407 -0.9504 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G02 mock treatment 8.8378895E7 -1.38E7 -0.79 1.02100951E8 -2140000.0 -0.13 -0.6515 -0.8138 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G03 compound treatment 5.8733692E7 -4.35E7 -2.48 8.0696881E7 -2.35E7 -1.45 -2.7825 -0.9672 3079222 SPBio_001721 CC(=O)OC[C@H]1O[C@@H](Oc2cc(OC(=O)C)c3c(=O)cc(oc3c2)c4ccc(OC(=O)C)cc4)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G04 compound treatment 9.6436499E7 -5760000.0 -0.33 9.8260138E7 -5980000.0 -0.37 -0.4933 -0.9984 122 SPBio_001722 C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G05 compound treatment 5.5429627E7 -4.68E7 -2.67 5.2332802E7 -5.19E7 -3.2 -4.1523 -0.996 2060255 SPBio_001723 CC(=O)Oc1ccc(/C=C/c2cc(OC(=O)C)cc(OC(=O)C)c2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G06 compound treatment 9.8527103E7 -3670000.0 -0.21 1.02101049E8 -2140000.0 -0.13 -0.2414 -0.9749 1788 SPBio_001724 NC(=O)CS(=O)C(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G07 compound treatment 9.0291459E7 -1.19E7 -0.68 1.02987178E8 -1250000.0 -0.08 -0.5356 -0.7822 3054095 SPBio_001725 CCC(/C=C/[C@@H](C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G08 compound treatment 8.6098664E7 -1.61E7 -0.92 1.01166282E8 -3070000.0 -0.19 -0.7844 -0.8351 3304 SPBio_001726 Fc1ccc(cc1)C(=O)C2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G09 compound treatment 8.1872621E7 -2.03E7 -1.16 9.3247896E7 -1.1E7 -0.68 -1.3003 -0.9671 3174115 SPBio_001727 CC[C@H](CCC(C)[C@H]1CCC2C3CCC4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G10 compound treatment 2.876305E7 -7.34E7 -4.2 2.9537445E7 -7.47E7 -4.6 -6.2236 -0.9989 3055363 SPBio_001728 COc1cc(/C=C/C(=C/C(=O)\C=C\c2ccc(O)c(OC)c2)/O)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G11 compound treatment 4.4842876E7 -5.74E7 -3.28 4.8276968E7 -5.6E7 -3.45 -4.757 -0.9997 2060290 SPBio_001729 C[C@@H]1OC(O[C@H]2CC[C@@]3(C)C(CC[C@]4(C)C3CC=C5C6CC(C)(C)CC[C@@]6(C(O)C[C@]54C)C(=O)O[C@@H]7OC[C@H](O)[C@@H](O)[C@H]7OC8O[C@@H](C)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@H]8O)C2(C)C)[C@H](O)[C@H](O)[C@H]1O[C@@H]%10OC[C@@H](O)[C@H](O)[C@H]%10O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G12 compound treatment 8.5923763E7 -1.63E7 -0.93 8.3035533E7 -2.12E7 -1.31 -1.5817 -0.9861 1912 SPBio_001730 [O-][N+](=O)c1cccc2cn[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G13 compound treatment 8.7886623E7 -1.43E7 -0.82 8.9687542E7 -1.45E7 -0.9 -1.2125 -0.9989 3055472 SPBio_001731 CC(C)CCCC(C)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G14 compound treatment 8.9466492E7 -1.27E7 -0.73 9.0865642E7 -1.34E7 -0.82 -1.0973 -0.9981 1003535 SPBio_001732 ONC(=O)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G15 compound treatment 9.1354568E7 -1.08E7 -0.62 9.0666318E7 -1.36E7 -0.84 -1.0297 -0.9891 3055308 SPBio_001733 COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]3[C@@H](C)[C@@H](O)C[C@@H]31 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G16 compound treatment 9.0223447E7 -1.2E7 -0.68 8.596919E7 -1.83E7 -1.13 -1.2801 -0.9715 2060198 SPBio_001734 COc1ccc2C=C3c4cc(OC)c(OC)cc4OCC3(O)Oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G17 compound treatment 4.2496298E7 -5.97E7 -3.41 4.6876608E7 -5.74E7 -3.54 -4.9128 -0.9998 2060301 SPBio_001735 COc1ccc(cc1O)c2cc(=O)c3c(O)cc(O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G18 compound treatment 9.2225887E7 -9970000.0 -0.57 8.9669673E7 -1.46E7 -0.9 -1.0379 -0.9759 3198534 SPBio_001736 OCC(O)CC(O)CCCCCCCCCCCC=C.OCC(O)CC(O)CCCCCCCCCCCC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G19 compound treatment 8.3399181E7 -1.88E7 -1.07 7.9645893E7 -2.46E7 -1.52 -1.8315 -0.9858 1119359 SPBio_001737 COc1cc2ccc(=O)oc2c(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G20 compound treatment 9.6329871E7 -5870000.0 -0.34 8.6050244E7 -1.82E7 -1.12 -1.0298 -0.8801 3198535 SPBio_001738 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C[C@H](O)[C@]2(C)C3CC[C@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G21 compound treatment 1.05589841E8 3390000.0 0.19 1.0019021E8 -4050000.0 -0.25 -0.0392 -0.1242 3055306 SPBio_001739 C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)[C@@H]2[C@H]1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G22 compound treatment 1.1041865E8 8220000.0 0.47 1.00494186E8 -3740000.0 -0.23 0.1691 0.3231 734 SPBio_001740 CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G23 mock treatment 9.0343977E7 -1.19E7 -0.68 9.3961463E7 -1.03E7 -0.63 -0.9269 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 G24 mock treatment 1.05099516E8 2900000.0 0.17 1.07138695E8 2900000.0 0.18 0.2438 0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H01 mock treatment 1.05035877E8 2840000.0 0.16 1.00493708E8 -3740000.0 -0.23 -0.0484 -0.1716 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H02 mock treatment 1.04751315E8 2560000.0 0.15 1.06234607E8 2000000.0 0.12 0.1903 0.9964 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H03 compound treatment 1.08561641E8 6370000.0 0.36 1.08310793E8 4070000.0 0.25 0.4348 0.9836 1007364 SPBio_001741 CCOC(=O)C1C(C=C(C)C)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H04 compound treatment 1.04830974E8 2640000.0 0.15 1.05567714E8 1330000.0 0.08 0.1645 0.9592 2522 SPBio_001742 CNC(=O)Oc1cccc2CC(C)(C)Oc21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H05 compound treatment 1.04440038E8 2240000.0 0.13 1.03191901E8 -1050000.0 -0.06 0.0451 0.3144 852250 SPBio_001743 C1CCC(NC1)c2cccnc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H06 compound treatment 1.01449604E8 -746000.0 -0.04 1.02287794E8 -1950000.0 -0.12 -0.1151 -0.9029 3172728 SPBio_001744 CNC(=O)O/N=C(/C)\SC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H07 compound treatment 1.00076391E8 -2120000.0 -0.12 9.8595859E7 -5640000.0 -0.35 -0.3316 -0.9004 1610 SPBio_001745 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H08 compound treatment 1.00244446E8 -1950000.0 -0.11 9.7561338E7 -6680000.0 -0.41 -0.3699 -0.8675 2527 SPBio_001746 COP(=S)(OC)Oc1ccc(Sc2ccc(OP(=S)(OC)OC)cc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H09 compound treatment 9.6795829E7 -5400000.0 -0.31 9.6745197E7 -7490000.0 -0.46 -0.5448 -0.9808 1014978 SPBio_001747 OCC(O)C(O)C(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H10 compound treatment 9.6854411E7 -5340000.0 -0.31 9.6164159E7 -8070000.0 -0.5 -0.5678 -0.9725 2530 SPBio_001748 CCCSP(=O)(OCC)SCCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H11 compound treatment 8.9905615E7 -1.23E7 -0.7 8.9762044E7 -1.45E7 -0.89 -1.1276 -0.993 1003823 SPBio_001749 Cc1occc(=O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H12 compound treatment 9.2704208E7 -9490000.0 -0.54 9.0061423E7 -1.42E7 -0.87 -1.0015 -0.9737 2532 SPBio_001750 CC(C)(C)c1ccc(OC2CCCCC2OS(=O)OCC#C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H13 compound treatment 8.5839156E7 -1.64E7 -0.93 8.7546891E7 -1.67E7 -1.03 -1.3885 -0.9989 1052459 SPBio_001751 COc1c2ccoc2cc3oc(C)cc(=O)c13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H14 compound treatment 8.8761777E7 -1.34E7 -0.77 9.066383E7 -1.36E7 -0.84 -1.1345 -0.9991 2491 SPBio_001752 COC(=O)c1c(Cl)c(Cl)c(C(=O)OC)c(Cl)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H15 compound treatment 9.1744753E7 -1.05E7 -0.6 9.4126008E7 -1.01E7 -0.62 -0.8631 -0.9998 2069297 SPBio_001753 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H16 compound treatment 8.4340904E7 -1.79E7 -1.02 9.1114817E7 -1.31E7 -0.81 -1.2935 -0.9934 2492 SPBio_001754 CC(C)Nc1nc(Cl)nc(NC(C)C)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H17 compound treatment 9.3152093E7 -9040000.0 -0.52 9.5523247E7 -8710000.0 -0.54 -0.7453 -0.9998 470 SPBio_001755 OC(=O)CCCc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H18 compound treatment 9.0855535E7 -1.13E7 -0.65 9.2683013E7 -1.16E7 -0.71 -0.9619 -0.9989 2493 SPBio_001756 CCC(=O)Nc1ccc(Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H19 compound treatment 9.3726644E7 -8470000.0 -0.48 9.6162522E7 -8070000.0 -0.5 -0.6942 -0.9999 1000133 SPBio_001757 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H20 compound treatment 9.3046021E7 -9150000.0 -0.52 9.2777473E7 -1.15E7 -0.71 -0.8693 -0.989 2494 SPBio_001758 CCNc1nc(Cl)nc(NCC)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H21 compound treatment 9.6751747E7 -5440000.0 -0.31 9.6064887E7 -8170000.0 -0.5 -0.5762 -0.9732 2060499 SPBio_001759 OC[C@H]1O[C@@H](Oc2cc(O)c3c(=O)cc(oc3c2)c4ccc(O)cc4)[C@H](O[C@@H]5OC[C@](O)(CO)[C@H]5O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H22 compound treatment 9.1898711E7 -1.03E7 -0.59 9.2310036E7 -1.19E7 -0.74 -0.936 -0.9939 2495 SPBio_001760 CCNc1nc(Cl)nc(NC(C)C)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H23 mock treatment 1.05778048E8 3580000.0 0.2 9.6712313E7 -7520000.0 -0.46 -0.1832 -0.3614 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 H24 mock treatment 1.07693653E8 5500000.0 0.31 1.04588737E8 352000.0 0.02 0.2375 0.7541 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I01 mock treatment 1.00360469E8 -1840000.0 -0.1 1.00058625E8 -4180000.0 -0.26 -0.2563 -0.9216 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I02 mock treatment 9.1869845E7 -1.03E7 -0.59 1.03668343E8 -569000.0 -0.04 -0.4421 -0.7478 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I03 compound treatment 7.5690363E7 -2.65E7 -1.51 1.06935744E8 2700000.0 0.17 -0.9535 -0.6257 2060321 SPBio_001761 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4c(=O)cc(oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I04 compound treatment 9.0346983E7 -1.18E7 -0.68 9.7954097E7 -6280000.0 -0.39 -0.7527 -0.9649 2060201 SPBio_001762 CC(=O)OCC(O)CC(O)CCCCCCCCCCCC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I05 compound treatment 1.14971854E8 1.28E7 0.73 1.01872085E8 -2370000.0 -0.15 0.4132 0.555 3173485 SPBio_001763 OC[C@H]1O[C@H](Oc2cccc3[C@H]([C@@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(=O)O)c8cc(cc(O)c8C(=O)c23)C(=O)O)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I06 compound treatment 9.851246E7 -3680000.0 -0.21 9.3035868E7 -1.12E7 -0.69 -0.6371 -0.8826 2069229 SPBio_001764 Oc1ccc2oc3ccccc3c(=O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I07 compound treatment 3.0432696E7 -7.18E7 -4.1 3.2994528E7 -7.12E7 -4.39 -6.0054 -0.9994 2060342 SPBio_001765 O[C@@H]1[C@H](Oc2cc(O)ccc2C1=O)c3cc(O)c(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I08 compound treatment 8.6391735E7 -1.58E7 -0.9 9.8892187E7 -5350000.0 -0.33 -0.8717 -0.9066 2060279 SPBio_001766 CC(=O)OC1CC[C@@]2(C)C(CC[C@]3(C)C2CCC4C5CC(C)(C)CCC5(CC[C@]43C)C(=O)O)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I09 compound treatment 6.8719732E7 -3.35E7 -1.91 7.5506897E7 -2.87E7 -1.77 -2.6051 -0.9993 2060442 SPBio_001767 CCC(N)C(O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I10 compound treatment 8.5476916E7 -1.67E7 -0.96 9.6079314E7 -8160000.0 -0.5 -1.0312 -0.9551 2069285 SPBio_001768 CCCCCC(=O)Cc1cc(O)cc(O)c1C(=O)Oc2cc(CC(=O)CCCCC)c(C(=O)O)c(OC)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I11 compound treatment 8.7172741E7 -1.5E7 -0.86 9.163988E7 -1.26E7 -0.78 -1.1562 -0.9987 2060343 SPBio_001769 CCCc1occc(=O)c1/C=C/O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I12 compound treatment 8.4927729E7 -1.73E7 -0.99 9.0212127E7 -1.4E7 -0.86 -1.3092 -0.9978 2524 SPBio_001770 COP(=O)(NC(=O)C)SC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I13 compound treatment 8.8499176E7 -1.37E7 -0.78 9.1471181E7 -1.28E7 -0.79 -1.11 -1.0 2060303 SPBio_001771 Cc1occc(=O)c1/C=C/O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I14 compound treatment 8.4557958E7 -1.76E7 -1.01 8.724748E7 -1.7E7 -1.05 -1.4533 -0.9998 2528 SPBio_001772 CNC(=O)Oc1cccc2OC(C)(C)Oc21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I15 compound treatment 2.9908763E7 -7.23E7 -4.13 2.9511137E7 -7.47E7 -4.61 -6.1784 -0.9985 1000697 SPBio_001773 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(O[C@@H]4O[C@@H]5CO[C@H](OC5[C@H](O)[C@H]4O)c6cccs6)c7cc8OCOc8cc27 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I16 compound treatment 4.3889213E7 -5.83E7 -3.33 3.5892085E7 -6.83E7 -4.21 -5.3353 -0.9933 2060192 SPBio_001774 CC1(C)CC2C1CCC3(C)CCCC2(O)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I17 compound treatment 9.6013649E7 -6180000.0 -0.35 9.3125952E7 -1.11E7 -0.68 -0.7342 -0.9526 1835 SPBio_001775 CCCc1nn(C)c2c(=O)[nH]c(nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I18 compound treatment 1.00241517E8 -1950000.0 -0.11 9.8294768E7 -5940000.0 -0.37 -0.338 -0.8826 3079231 SPBio_001776 CC1(C)O[C@H]2CC(=O)OC[C@@]23[C@H]1CC(=O)[C@]4(C)[C@@H]3CC[C@@]5(C)[C@@H](OC(=O)[C@H]6O[C@]654)c7ccoc7 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I19 compound treatment 2.8027358E7 -7.42E7 -4.24 2.7842069E7 -7.64E7 -4.71 -6.3272 -0.9986 2060453 SPBio_001777 Clc1c(Cl)c(C#N)c(Cl)c(C#N)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I20 compound treatment 8.1544275E7 -2.07E7 -1.18 6.0647193E7 -4.36E7 -2.69 -2.7346 -0.9318 1393 SPBio_001778 CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I21 compound treatment 1.01424776E8 -771000.0 -0.04 9.5538163E7 -8700000.0 -0.54 -0.4103 -0.7627 2060298 SPBio_001779 CCCCCC1C(CC(=O)O)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I22 compound treatment 9.9874719E7 -2320000.0 -0.13 9.4561167E7 -9680000.0 -0.6 -0.5156 -0.8438 3055569 SPBio_001780 OCc1cccnc1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I23 mock treatment 9.7288995E7 -4910000.0 -0.28 9.7166967E7 -7070000.0 -0.44 -0.5065 -0.9773 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 I24 mock treatment 1.01937266E8 -259000.0 -0.01 1.1063247E8 6400000.0 0.39 0.2683 0.6801 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J01 mock treatment 1.04594829E8 2400000.0 0.14 1.01344545E8 -2890000.0 -0.18 -0.0291 -0.1296 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J02 mock treatment 1.07157317E8 4960000.0 0.28 1.06267165E8 2030000.0 0.13 0.289 0.9324 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J03 compound treatment 1.09583566E8 7390000.0 0.42 1.02743953E8 -1490000.0 -0.09 0.2335 0.5403 2060362 SPBio_001781 COc1ccc(cc1)c2c(OC)c3c(OC)c4C=CC(C)(C)Oc4cc3oc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J04 compound treatment 1.06493414E8 4300000.0 0.25 1.02380502E8 -1860000.0 -0.11 0.0927 0.3423 2497 SPBio_001782 CNC(=O)N(C)c1nnc(s1)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J05 compound treatment 1.04570994E8 2380000.0 0.14 9.7310229E7 -6930000.0 -0.43 -0.206 -0.4597 2060104 SPBio_001783 COc1cc(C)c2c(=O)c3c(O)cc(O)cc3oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J06 compound treatment 9.8839287E7 -3360000.0 -0.19 9.735834E7 -6880000.0 -0.42 -0.4355 -0.9357 2498 SPBio_001784 COc1c(Cl)ccc(Cl)c1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J07 compound treatment 9.7896311E7 -4300000.0 -0.25 9.0837357E7 -1.34E7 -0.83 -0.7578 -0.8794 1029490 SPBio_001785 COc1cc(O)c(C)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J08 compound treatment 9.9384036E7 -2810000.0 -0.16 9.7921907E7 -6320000.0 -0.39 -0.3889 -0.9234 2499 SPBio_001786 CCCCN(CC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J09 compound treatment 9.723879E7 -4960000.0 -0.28 9.5306208E7 -8930000.0 -0.55 -0.5896 -0.9523 1060118 SPBio_001787 COc1cc(OC)c2c(=O)c(OC)c(oc2c1)c3ccc(OC)c(OC)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J10 compound treatment 9.3013249E7 -9180000.0 -0.52 9.3517579E7 -1.07E7 -0.66 -0.8383 -0.9935 2500 SPBio_001788 COc1nc(NC(C)C)nc(NC(C)C)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J11 compound treatment 9.3087972E7 -9110000.0 -0.52 9.4304105E7 -9930000.0 -0.61 -0.801 -0.9967 2542 SPBio_001789 CCCCOC(=O)c1ccccc1C(=O)OCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J12 compound treatment 9.2194755E7 -1.0E7 -0.57 8.9714526E7 -1.45E7 -0.9 -1.0372 -0.9765 2501 SPBio_001790 CCc1cccc(C)c1N(C(C)COC)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J13 compound treatment 7.3797362E7 -2.84E7 -1.62 6.9893577E7 -3.43E7 -2.12 -2.6446 -0.9914 2060080 SPBio_001791 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6CC4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J14 compound treatment 9.227236E7 -9920000.0 -0.57 9.391485E7 -1.03E7 -0.64 -0.851 -0.9984 2502 SPBio_001792 Clc1cccc(Cl)c1C#N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J15 compound treatment 9.1205021E7 -1.1E7 -0.63 9.192668E7 -1.23E7 -0.76 -0.9808 -0.9956 1471 SPBio_001793 CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J16 compound treatment 8.9287035E7 -1.29E7 -0.74 9.3827107E7 -1.04E7 -0.64 -0.9754 -0.9976 2503 SPBio_001794 CSc1nc(NC(C)C)nc(NC(C)C)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J17 compound treatment 9.0614389E7 -1.16E7 -0.66 8.9447523E7 -1.48E7 -0.91 -1.1127 -0.9876 832 SPBio_001795 CCCn1c(=O)n(CCC)c2[nH]c(nc2c1=O)C3CCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J18 compound treatment 9.2592691E7 -9600000.0 -0.55 8.8899768E7 -1.53E7 -0.95 -1.0566 -0.9665 2504 SPBio_001796 CCCN(CCC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J19 compound treatment 2.8406415E7 -7.38E7 -4.22 2.8153911E7 -7.61E7 -4.69 -6.2983 -0.9986 3198539 SPBio_001797 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(\C)/C(=O)N)(OC5(C)C)C6=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J20 compound treatment 9.6897585E7 -5300000.0 -0.3 9.7920525E7 -6320000.0 -0.39 -0.4894 -0.9923 2505 SPBio_001798 CC(C)N1C(=O)c2ccccc2NS1(=O)=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J21 compound treatment 7.6931694E7 -2.53E7 -1.44 7.8656203E7 -2.56E7 -1.58 -2.136 -0.999 2069318 SPBio_001799 C[C@@H](NC(=O)/C(=C\c1ccc(O)c(O)c1)/C#N)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J22 compound treatment 9.2393415E7 -9800000.0 -0.56 9.2344774E7 -1.19E7 -0.73 -0.9145 -0.9912 2537 SPBio_001800 COc1ccc(cc1)C(c2ccc(OC)cc2)C(Cl)(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J23 mock treatment 1.07407991E8 5210000.0 0.3 1.05806327E8 1570000.0 0.1 0.279 0.8909 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 J24 mock treatment 1.03618654E8 1420000.0 0.08 1.07244834E8 3010000.0 0.19 0.1886 0.9316 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K01 mock treatment 1.00086E8 -2110000.0 -0.12 9.8174564E7 -6060000.0 -0.37 -0.3495 -0.8901 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K02 mock treatment 9.0413978E7 -1.18E7 -0.67 9.0637963E7 -1.36E7 -0.84 -1.0689 -0.9941 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K03 compound treatment 3.7776877E7 -6.44E7 -3.68 4.4351242E7 -5.99E7 -3.69 -5.2136 -1.0 2060271 SPBio_001801 CCC(C)C(=O)c1c(O)c(C)c2oc3c(C)c(O)c(C(=O)C(C)CC)c(O)c3c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K04 compound treatment 9.9190881E7 -3010000.0 -0.17 1.04288075E8 50900.0 0.0 -0.1192 -0.6941 1048 SPBio_001802 CCn1cc(C(=O)O)c(=O)c2cc(F)c(nc12)N3CCNCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K05 compound treatment 4.010493E7 -6.21E7 -3.55 4.0610174E7 -6.36E7 -3.92 -5.2826 -0.9988 1386109 SPBio_001803 Oc1ccc2c(=O)c(O)c(oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K06 compound treatment 2.8185513E7 -7.4E7 -4.23 2.8136547E7 -7.61E7 -4.69 -6.308 -0.9987 709 SPBio_001804 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K07 compound treatment 9.3888592E7 -8310000.0 -0.47 1.00979336E8 -3260000.0 -0.2 -0.4777 -0.9267 907120 SPBio_001805 CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K08 compound treatment 8.3472415E7 -1.87E7 -1.07 9.6522517E7 -7710000.0 -0.48 -1.0929 -0.9333 744 SPBio_001806 Cn1cnc2[nH]c(=O)n(C)c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K09 compound treatment 3.0967756E7 -7.12E7 -4.07 3.1060067E7 -7.32E7 -4.51 -6.0681 -0.9987 2060459 SPBio_001807 OC[C@H]1OC2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K10 compound treatment 5.3610211E7 -4.86E7 -2.78 6.1681044E7 -4.26E7 -2.62 -3.8184 -0.9996 1416 SPBio_001808 Cn1c(=O)n(C)c2[nH]c(nc2c1=O)C3CCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K11 compound treatment 8.5816863E7 -1.64E7 -0.94 9.1035959E7 -1.32E7 -0.81 -1.2373 -0.9976 1001314 SPBio_001809 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)[C@@H]4N[C@@H](COCCOC)O[C@H]([C@H]4C)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K12 compound treatment 8.0879862E7 -2.13E7 -1.22 8.0293135E7 -2.39E7 -1.48 -1.9051 -0.9955 1505 SPBio_001810 CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K13 compound treatment 8.7287116E7 -1.49E7 -0.85 8.7893288E7 -1.63E7 -1.01 -1.3149 -0.9965 3474314 SPBio_001811 CN1CCCCC1C(=O)Nc2c(C)cccc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K14 compound treatment 8.7762196E7 -1.44E7 -0.82 8.433248E7 -1.99E7 -1.23 -1.4509 -0.9813 1587004 SPBio_001812 COc1ccc(cc1)C2Sc3ccccc3N(CCN(C)C)C(=O)C2OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K15 compound treatment 8.1619061E7 -2.06E7 -1.18 7.3263215E7 -3.1E7 -1.91 -2.1816 -0.9729 2060476 SPBio_001813 C[C@H]1[C@@H]2CCC(=C3[C@@H]([C@H]2OC1=O)C(=CC3=O)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K16 compound treatment 9.3194799E7 -9000000.0 -0.51 8.2707442E7 -2.15E7 -1.33 -1.3022 -0.9149 4362 SPBio_001814 CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K17 compound treatment 7.3095658E7 -2.91E7 -1.66 6.6288091E7 -3.79E7 -2.34 -2.8301 -0.986 1095093 SPBio_001815 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K18 compound treatment 9.9946524E7 -2250000.0 -0.13 8.8124332E7 -1.61E7 -0.99 -0.7932 -0.792 80 SPBio_001816 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K19 compound treatment 1.03644309E8 1450000.0 0.08 9.4595602E7 -9640000.0 -0.59 -0.3617 -0.6028 1101055 SPBio_001817 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K20 compound treatment 1.07048403E8 4850000.0 0.28 9.5082788E7 -9150000.0 -0.56 -0.2029 -0.3227 3173239 SPBio_001818 CC(N/C(=N/C#N)/Nc1ccncc1)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K21 compound treatment 2.9699832E7 -7.25E7 -4.14 2.8971537E7 -7.53E7 -4.64 -6.2104 -0.9984 2060432 SPBio_001819 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)cc5cc4Cn3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K22 compound treatment 3.2587204E7 -6.96E7 -3.98 3.1855696E7 -7.24E7 -4.46 -5.968 -0.9984 1000056 SPBio_001820 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K23 mock treatment 9.5226591E7 -6970000.0 -0.4 9.4305838E7 -9930000.0 -0.61 -0.7145 -0.9783 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 K24 mock treatment 1.01265268E8 -931000.0 -0.05 1.03981012E8 -256000.0 -0.02 -0.0488 -0.8791 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L01 mock treatment 1.07753744E8 5560000.0 0.32 1.1191056E8 7670000.0 0.47 0.5591 0.9812 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L02 mock treatment 9.1064183E7 -1.11E7 -0.64 9.5202553E7 -9030000.0 -0.56 -0.8437 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L03 compound treatment 1.06819873E8 4620000.0 0.26 1.05821509E8 1580000.0 0.1 0.2559 0.9084 3079366 SPBio_001821 O[C@@H]1[C@H]2COC(O2)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L04 compound treatment 9.3272813E7 -8920000.0 -0.51 9.4672006E7 -9570000.0 -0.59 -0.7775 -0.9974 2538 SPBio_001822 ClC1C=CC2C1C3(Cl)C(=C(Cl)C2(Cl)C3(Cl)Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L05 compound treatment 1.07303449E8 5110000.0 0.29 1.06885092E8 2650000.0 0.16 0.3218 0.9623 1516 SPBio_001823 Nc1c2CCCCc2nc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L06 compound treatment 9.6566064E7 -5630000.0 -0.32 9.9914609E7 -4320000.0 -0.27 -0.4159 -0.9956 2539 SPBio_001824 CC1(C)C2(Cl)C(Cl)C1(Cl)C(Cl)(C(Cl)Cl)C(Cl)C2Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L07 compound treatment 9.6182601E7 -6010000.0 -0.34 9.6750032E7 -7490000.0 -0.46 -0.5694 -0.9895 26 SPBio_001825 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L08 compound treatment 9.5374396E7 -6820000.0 -0.39 9.6496228E7 -7740000.0 -0.48 -0.6131 -0.995 2541 SPBio_001826 ClC1=C(Cl)C2(Cl)C3COS(=O)OCC3C1(Cl)C2(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L09 compound treatment 9.5259654E7 -6940000.0 -0.4 9.7880822E7 -6360000.0 -0.39 -0.5574 -1.0 690 SPBio_001827 CC(C)NCC(O)COc1ccccc1CC=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L10 compound treatment 9.6488973E7 -5710000.0 -0.33 9.7845189E7 -6390000.0 -0.39 -0.5092 -0.9956 2540 SPBio_001828 ClC1=C(Cl)C2(Cl)C3C4CC(C=C4)C3C1(Cl)C2(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L11 compound treatment 4.7868143E7 -5.43E7 -3.1 4.2316113E7 -6.19E7 -3.82 -4.8945 -0.9948 1395 SPBio_001829 CC(COc1ccccc1)N(CCCl)Cc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L12 compound treatment 8.1911785E7 -2.03E7 -1.16 8.5006053E7 -1.92E7 -1.19 -1.658 -0.9999 2060152 SPBio_001830 CC(=O)O[C@@H]1CC2C(C)(C)C=CC(=O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L13 compound treatment 9.1274243E7 -1.09E7 -0.62 9.084021E7 -1.34E7 -0.83 -1.0253 -0.9905 74 SPBio_001831 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L14 compound treatment 8.9168593E7 -1.3E7 -0.74 9.3498846E7 -1.07E7 -0.66 -0.9945 -0.9983 3198541 SPBio_001832 CC(CCC=C(C)C)C1CC[C@@]2(C)C3=C(CC[C@]12C)C4(C)CC[C@H](OC(=O)C)C(C)(C)C4CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L15 compound treatment 8.7483179E7 -1.47E7 -0.84 9.2506544E7 -1.17E7 -0.72 -1.1059 -0.9972 907089 SPBio_001833 Cn1c(=O)n(C)c2ncn(CCCl)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L16 compound treatment 4.3152483E7 -5.9E7 -3.37 3.7224198E7 -6.7E7 -4.13 -5.307 -0.995 2060174 SPBio_001834 CC(=CCc1c2OC(C)(C)C=Cc2c(O)c3c(=O)c(O)c(oc13)c4ccccc4)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L17 compound treatment 9.2194151E7 -1.0E7 -0.57 9.7275371E7 -6960000.0 -0.43 -0.7076 -0.99 352677 SPBio_001835 COc1ccccc1N2CCNCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L18 compound treatment 8.6594757E7 -1.56E7 -0.89 9.5150316E7 -9090000.0 -0.56 -1.0266 -0.9749 3173763 SPBio_001836 O[C@@H]1C[C@](O)(C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H]1O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L19 compound treatment 9.5829967E7 -6370000.0 -0.36 9.6012719E7 -8220000.0 -0.51 -0.6158 -0.9868 718 SPBio_001837 Cn1c(=O)n(C)c2ncn(CCO)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L20 compound treatment 9.7816424E7 -4380000.0 -0.25 9.9734694E7 -4500000.0 -0.28 -0.3732 -0.9987 1171 SPBio_001838 CC(=O)Oc1ccccc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L21 compound treatment 8.7850798E7 -1.43E7 -0.82 9.0115521E7 -1.41E7 -0.87 -1.1953 -0.9996 1865 SPBio_001839 Clc1cccc(Nc2nnc(c3ccccc3)c4ccccc24)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L22 compound treatment 8.6157665E7 -1.6E7 -0.92 8.5864303E7 -1.84E7 -1.13 -1.449 -0.9945 2060217 SPBio_001840 COc1c(ccc2OC(C)(C)CCc12)C3COc4cc5OC(C)(C)C(O)Cc5cc4C3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L23 mock treatment 9.2711613E7 -9480000.0 -0.54 9.4792206E7 -9440000.0 -0.58 -0.795 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 L24 mock treatment 1.00400632E8 -1800000.0 -0.1 1.05876113E8 1640000.0 0.1 -0.0011 -0.0077 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M01 mock treatment 1.19850599E8 1.77E7 1.01 1.20662312E8 1.64E7 1.01 1.4294 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M02 mock treatment 9.6756244E7 -5440000.0 -0.31 1.04579571E8 342000.0 0.02 -0.2049 -0.6576 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M03 compound treatment 3.8799242E7 -6.34E7 -3.62 5.134462E7 -5.29E7 -3.26 -4.8675 -0.9986 1091368 SPBio_001841 CNc1ccccc1C(=O)N2CCc3c([nH]c4ccccc34)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M04 compound treatment 9.6019338E7 -6180000.0 -0.35 9.4223884E7 -1.0E7 -0.62 -0.6861 -0.9649 918 SPBio_001842 CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M05 compound treatment 1.113113E8 9120000.0 0.52 9.2827441E7 -1.14E7 -0.7 -0.129 -0.1473 1015899 SPBio_001843 NCC(=O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M06 compound treatment 2.8648702E7 -7.35E7 -4.2 2.8470124E7 -7.58E7 -4.67 -6.2747 -0.9986 693 SPBio_001844 CCN(CC)CCOc1ccc-2c(c1)C(=O)c3cc(OCCN(CC)CC)ccc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M07 compound treatment 8.8718464E7 -1.35E7 -0.77 9.6756182E7 -7480000.0 -0.46 -0.8707 -0.9699 1001204 SPBio_001845 COc1ccc(cc1)C(=O)CC(=O)c2ccc(cc2)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M08 compound treatment 9.330694E7 -8890000.0 -0.51 1.05103281E8 866000.0 0.05 -0.3215 -0.6293 2069286 SPBio_001846 CC(C)C(C)/C=C/C(C)[C@H]1CCC2C3=CCC4CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M09 compound treatment 4.1471495E7 -6.07E7 -3.47 4.7844408E7 -5.64E7 -3.48 -4.9121 -1.0 2060486 SPBio_001847 CC(=O)Oc1ccccc1C(=O)Oc2ccccc2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M10 compound treatment 6.4386146E7 -3.78E7 -2.16 8.3693413E7 -2.05E7 -1.27 -2.4234 -0.9676 3054523 SPBio_001848 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2[C@H]1C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M11 compound treatment 8.2015084E7 -2.02E7 -1.15 8.9667838E7 -1.46E7 -0.9 -1.4506 -0.9923 1000656 SPBio_001849 OC1=C([C@H]2CC[C@@H](CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M12 compound treatment 9.4231248E7 -7960000.0 -0.46 9.5922595E7 -8310000.0 -0.51 -0.6843 -0.9982 3198536 SPBio_001850 COc1ccc2C[C@H]3N(C)CC[C@]4([C@H]5Oc1c24)C3=CC[C@@H]5O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M13 compound treatment 8.7063547E7 -1.51E7 -0.86 8.6060412E7 -1.82E7 -1.12 -1.4038 -0.9918 2060416 SPBio_001851 Sc1nc2ccccc2s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M14 compound treatment 9.4226129E7 -7970000.0 -0.46 9.3556646E7 -1.07E7 -0.66 -0.7876 -0.9838 1014978 SPBio_001852 OCC(O)C(O)C(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M15 compound treatment 9.5301776E7 -6890000.0 -0.39 9.2506616E7 -1.17E7 -0.72 -0.7899 -0.9592 3079223 SPBio_001853 Cl.NCCS 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M16 compound treatment 9.6235726E7 -5960000.0 -0.34 8.9345788E7 -1.49E7 -0.92 -0.89 -0.9089 3079232 SPBio_001854 COc1ccc2c(=O)ccoc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M17 compound treatment 6.1317423E7 -4.09E7 -2.34 6.124449E7 -4.3E7 -2.65 -3.526 -0.998 3172732 SPBio_001855 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M18 compound treatment 8.6413814E7 -1.58E7 -0.9 7.5067439E7 -2.92E7 -1.8 -1.9092 -0.9491 3198537 SPBio_001856 CC(C)c1c(O)ccc2c1CCC3C(C)(CCCC32C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M19 compound treatment 1.02664495E8 469000.0 0.03 9.4337708E7 -9900000.0 -0.61 -0.4126 -0.6754 907181 SPBio_001857 NC(=N)NC(=O)c1nc(Cl)c(nc1N)N2CCCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M20 compound treatment 6.2143228E7 -4.01E7 -2.29 5.2152272E7 -5.21E7 -3.21 -3.8889 -0.9862 1049467 SPBio_001858 COC(=O)c1c(C)cc(OC(=O)c2c(C)cc(O)c(C=O)c2O)c(C)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M21 compound treatment 8.9680729E7 -1.25E7 -0.72 8.4587726E7 -1.96E7 -1.21 -1.3622 -0.9684 1734308 SPBio_001859 Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M22 compound treatment 1.0009746E8 -2100000.0 -0.12 8.7260769E7 -1.7E7 -1.05 -0.8248 -0.783 2069239 SPBio_001860 Cc1cc(O)c2C(=O)c3c(O)c(C)cc(O)c3C(=O)c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M23 mock treatment 9.374757E7 -8450000.0 -0.48 9.3449545E7 -1.08E7 -0.66 -0.8116 -0.9876 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 M24 mock treatment 1.11656719E8 9460000.0 0.54 1.03165943E8 -1070000.0 -0.07 0.3356 0.6162 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N01 mock treatment 1.15899773E8 1.37E7 0.78 1.07714366E8 3480000.0 0.21 0.7054 0.8687 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N02 mock treatment 1.1103974E8 8840000.0 0.51 1.08570328E8 4330000.0 0.27 0.5463 0.9556 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N03 compound treatment 9.9483354E7 -2710000.0 -0.16 1.01884158E8 -2350000.0 -0.15 -0.2122 -0.9994 1055442 SPBio_001861 Nc1nc(O)c2nc(cnc2n1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N04 compound treatment 1.05966162E8 3770000.0 0.22 9.9164564E7 -5070000.0 -0.31 -0.0687 -0.181 2060172 SPBio_001862 CC1(C)CC2C1CCC3(CBr)CCC4C(CC(=O)O)C(=O)OC24C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N05 compound treatment 9.8572476E7 -3620000.0 -0.21 9.8538045E7 -5700000.0 -0.35 -0.3948 -0.9682 2060299 SPBio_001863 CC1(C)CC2/C(=C/C=C/C(C)(O)CCC21O)/CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N06 compound treatment 9.1044808E7 -1.12E7 -0.64 9.1233558E7 -1.3E7 -0.8 -1.0174 -0.9935 1019872 SPBio_001864 COc1cc2COC(=O)c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N07 compound treatment 9.284221E7 -9350000.0 -0.53 9.1525566E7 -1.27E7 -0.78 -0.9321 -0.9826 2069306 SPBio_001865 C[C@@]12CCC3C(CCC4=CC(=O)C=C[C@]34C)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N08 compound treatment 9.4167435E7 -8030000.0 -0.46 9.3161545E7 -1.11E7 -0.68 -0.8072 -0.9813 2060193 SPBio_001866 CC1(C)C2CC1C(=C)C(N)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N09 compound treatment 9.0563443E7 -1.16E7 -0.66 9.8885168E7 -5350000.0 -0.33 -0.7034 -0.9477 3173755 SPBio_001867 C[C@@]12CC(=O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N10 compound treatment 9.0747596E7 -1.14E7 -0.65 9.1094074E7 -1.31E7 -0.81 -1.0355 -0.9944 2060191 SPBio_001868 CC1(C)CC2C1CCC(=O)C(CCC2=C)C3CC(=O)OC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N11 compound treatment 8.9989864E7 -1.22E7 -0.7 9.0329488E7 -1.39E7 -0.86 -1.0995 -0.9948 3177324 SPBio_001869 C[C@@]12CC(=O)C3C(CC[C@@H]4C[C@H](O)CC[C@@]43C)C2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N12 compound treatment 9.3853736E7 -8340000.0 -0.48 9.1470909E7 -1.28E7 -0.79 -0.8936 -0.9712 1114909 SPBio_001870 COc1cc(CC=C)ccc1OC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N13 compound treatment 8.7050811E7 -1.51E7 -0.87 8.3338832E7 -2.09E7 -1.29 -1.523 -0.9813 2069240 SPBio_001871 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CC[C@@H]4C[C@@H](CC[C@]4(C)C3C(=O)C[C@@]21C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N14 compound treatment 9.4005957E7 -8190000.0 -0.47 9.1166066E7 -1.31E7 -0.81 -0.9007 -0.9666 3054634 SPBio_001872 COc1c(CC=C(C)C)c2OC(C)(C)C=Cc2c3oc(=O)c(c(O)c13)c4ccc(O)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N15 compound treatment 9.0149255E7 -1.2E7 -0.69 9.2822055E7 -1.14E7 -0.7 -0.9844 -0.9999 2060261 SPBio_001873 CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]2CCC4[C@@]5(C)CCCC(C)(C)C5[C@@H](O)C[C@]43C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N16 compound treatment 9.1792093E7 -1.04E7 -0.59 9.2418941E7 -1.18E7 -0.73 -0.9356 -0.9949 3174602 SPBio_001874 O=c1[nH]cnc2nc[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N17 compound treatment 9.100501E7 -1.12E7 -0.64 9.5553969E7 -8680000.0 -0.54 -0.8307 -0.9961 1506 SPBio_001875 OCc1cc(=O)c(O)co1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N18 compound treatment 8.0320725E7 -2.19E7 -1.25 9.0726056E7 -1.35E7 -0.83 -1.4729 -0.9805 3174484 SPBio_001876 C[C@@]12CCC3C(CC[C@H]4C[C@@H](O)CC[C@@]43C)C2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N19 compound treatment 6.4121089E7 -3.81E7 -2.18 6.3930681E7 -4.03E7 -2.48 -3.2956 -0.9978 2060349 SPBio_001877 CCC[C@H]1CC2=C(C[C@@H](CC)CC3=C1C(=O)OC3=O)C(=O)OC2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N20 compound treatment 1.06138028E8 3940000.0 0.23 1.06233312E8 2000000.0 0.12 0.2463 0.9595 2060302 SPBio_001878 CC(C)CCC[C@@H](C)CCC[C@@H](C)CC/C(=C/CO)/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N21 compound treatment 5.5950227E7 -4.62E7 -2.64 6.6065642E7 -3.82E7 -2.35 -3.5327 -0.9983 3198540 SPBio_001879 COC(=O)/C(=C/CC1(OC(C)(C)C2CC3C=C4C(=O)c5cc6C7CC(C)(CCC7=C(C)C)Oc6c(CCC(C)(C)Cl)c5OC241)C3=O)/C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N22 compound treatment 1.0496786E8 2770000.0 0.16 9.2356256E7 -1.19E7 -0.73 -0.4058 -0.5416 3174493 SPBio_001880 N[C@H]([C@@H](O)[C@H](O)[C@H](O)CO)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N23 mock treatment 8.7226905E7 -1.5E7 -0.86 9.0018417E7 -1.42E7 -0.88 -1.2247 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 N24 mock treatment 9.989652E7 -2300000.0 -0.13 1.00625504E8 -3610000.0 -0.22 -0.2504 -0.9684 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O01 mock treatment 1.17136503E8 1.49E7 0.85 1.17240907E8 1.3E7 0.8 1.1706 0.9995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O02 mock treatment 9.2028421E7 -1.02E7 -0.58 1.05496983E8 1260000.0 0.08 -0.356 -0.6072 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O03 compound treatment 3.8858849E7 -6.33E7 -3.62 4.7318577E7 -5.69E7 -3.51 -5.0406 -0.9999 1000094 SPBio_001881 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O04 compound treatment 1.04643964E8 2450000.0 0.14 1.03382032E8 -855000.0 -0.05 0.0617 0.4124 3079279 SPBio_001882 COC(=O)c1c(C)cc(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O05 compound treatment 3.0126184E7 -7.21E7 -4.12 2.9785149E7 -7.45E7 -4.59 -6.1577 -0.9985 2101 SPBio_001883 Oc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O06 compound treatment 8.9504224E7 -1.27E7 -0.73 8.9928993E7 -1.43E7 -0.88 -1.1366 -0.9953 3055391 SPBio_001884 OC[C@H]1O[C@@H](Oc2cc(O)c3c(=O)cc(oc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O07 compound treatment 3.1174407E7 -7.1E7 -4.06 3.0285551E7 -7.4E7 -4.56 -6.0935 -0.9983 3480079 SPBio_001885 COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O08 compound treatment 8.9487784E7 -1.27E7 -0.73 9.8514111E7 -5720000.0 -0.35 -0.763 -0.945 3198538 SPBio_001886 COc1cc2OCOc2cc1c3coc4cc(OC)c(OC)cc4c3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O09 compound treatment 3.6261283E7 -6.59E7 -3.77 3.5574125E7 -6.87E7 -4.23 -5.6574 -0.9983 3177524 SPBio_001887 CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc2ccccc2)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O10 compound treatment 7.1691137E7 -3.05E7 -1.74 7.2529423E7 -3.17E7 -1.95 -2.6148 -0.9984 2060249 SPBio_001888 COc1ccc(cc1)c2coc3c(OC)c(O)ccc3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O11 compound treatment 8.8708227E7 -1.35E7 -0.77 9.3196065E7 -1.1E7 -0.68 -1.0263 -0.9981 1635 SPBio_001889 CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5nnn[nH]5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O12 compound treatment 9.3423717E7 -8770000.0 -0.5 9.7951495E7 -6290000.0 -0.39 -0.6285 -0.9919 3079280 SPBio_001890 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O13 compound treatment 1.00823912E8 -1370000.0 -0.08 1.02681135E8 -1560000.0 -0.1 -0.1233 -0.995 1000155 SPBio_001891 C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O14 compound treatment 9.9412227E7 -2780000.0 -0.16 1.01899509E8 -2340000.0 -0.14 -0.2144 -0.9988 1002679 SPBio_001892 OCC(O)C(O)C(O)C(O)C(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O15 compound treatment 1.02568911E8 373000.0 0.02 9.5723243E7 -8510000.0 -0.52 -0.356 -0.6778 1606766 SPBio_001893 CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)c3ccccc3c4nnn[nH]4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O16 compound treatment 9.6209003E7 -5990000.0 -0.34 9.1447248E7 -1.28E7 -0.79 -0.7994 -0.9302 2060353 SPBio_001894 Cc1c(O)cc(O)c2c(=O)c(coc12)c3ccc(O)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O17 compound treatment 7.764756E7 -2.45E7 -1.4 7.5704121E7 -2.85E7 -1.76 -2.2358 -0.9937 3059445 SPBio_001895 CCCCCCCCCCC[C@@H](C[C@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O18 compound treatment 8.865227E7 -1.35E7 -0.77 8.4807672E7 -1.94E7 -1.2 -1.3942 -0.9777 2060132 SPBio_001896 CC1=CC(=O)C2C(C)(C)CCC[C@]2(C)[C@@]1(O)CCc3ccoc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O19 compound treatment 9.6567033E7 -5630000.0 -0.32 8.675836E7 -1.75E7 -1.08 -0.9893 -0.8799 3480074 SPBio_001897 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O20 compound treatment 7.2577288E7 -2.96E7 -1.69 7.7600125E7 -2.66E7 -1.64 -2.358 -0.9999 2060134 SPBio_001898 COc1cc2ccc(=O)oc2c3ccoc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O21 compound treatment 1.15845619E8 1.36E7 0.78 1.056973E8 1460000.0 0.09 0.6153 0.7835 907463 SPBio_001899 Cc1nc2ccccn2c(=O)c1CCN3CCC(CC3)C(=O)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O22 compound treatment 8.5232482E7 -1.7E7 -0.97 8.3046917E7 -2.12E7 -1.31 -1.6092 -0.9892 2060220 SPBio_001900 CC/1[C@H]2C[C@@H](C\C1=N/O)C2(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O23 mock treatment 9.2486974E7 -9710000.0 -0.55 9.5630107E7 -8610000.0 -0.53 -0.7675 -0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 O24 mock treatment 1.0527693E8 3080000.0 0.18 1.07776145E8 3540000.0 0.22 0.2788 0.9944 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P01 mock treatment 1.20852357E8 1.87E7 1.07 1.19108615E8 1.49E7 0.92 1.4022 0.9972 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P02 mock treatment 1.17043668E8 1.48E7 0.85 1.16323981E8 1.21E7 0.75 1.1269 0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P03 compound treatment 1.14364625E8 1.22E7 0.7 1.13897104E8 9660000.0 0.6 0.9128 0.997 1087705 SPBio_001901 CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P04 compound treatment 1.1249763E8 1.03E7 0.59 1.13940015E8 9700000.0 0.6 0.8392 1.0 290 SPBio_001902 CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)C)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P05 compound treatment 5.2652204E7 -4.95E7 -2.83 4.5422395E7 -5.88E7 -3.63 -4.5658 -0.9925 2543 SPBio_001903 CCCCCCCCCc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P06 compound treatment 9.8948941E7 -3250000.0 -0.19 1.07495261E8 3260000.0 0.2 0.0108 0.0395 2060293 SPBio_001904 C[C@@H]1CC[C@H]2C(C)(C)C3C[C@@]12CC[C@@]3(C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P07 compound treatment 9.9561277E7 -2630000.0 -0.15 9.968281E7 -4550000.0 -0.28 -0.305 -0.9574 2069261 SPBio_001905 COc1cc2OCC3Oc4c5C=CC(C)(C)Oc5cc(O)c4C(=O)C3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P08 compound treatment 9.5998168E7 -6200000.0 -0.35 9.9604791E7 -4630000.0 -0.29 -0.4524 -0.9943 1305 SPBio_001906 CCOC(=O)O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccc(OC)cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P09 compound treatment 4.9813089E7 -5.24E7 -2.99 5.0621291E7 -5.36E7 -3.31 -4.4539 -0.9988 2060403 SPBio_001907 COc1ccc(C2COc3cc(O)ccc3C2)c(OC)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P10 compound treatment 4.8060921E7 -5.41E7 -3.09 4.8890027E7 -5.53E7 -3.41 -4.6002 -0.9988 2325 SPBio_001908 NC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P11 compound treatment 7.1976324E7 -3.02E7 -1.73 7.9649823E7 -2.46E7 -1.52 -2.293 -0.9979 3079389 SPBio_001909 COc1cc(OC)c(C(=O)c2ccc(O)cc2)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P12 compound treatment 6.0320651E7 -4.19E7 -2.39 6.0178297E7 -4.41E7 -2.72 -3.6127 -0.998 2544 SPBio_001910 CCOCN(C(=O)CCl)c1c(C)cccc1CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P13 compound treatment 1.01985292E8 -211000.0 -0.01 1.08572504E8 4340000.0 0.27 0.1805 0.6746 2060426 SPBio_001911 COc1c(O)cccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P14 compound treatment 9.4100138E7 -8100000.0 -0.46 1.01568031E8 -2670000.0 -0.16 -0.4435 -0.9032 1004713 SPBio_001912 CNc1ccccc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P15 compound treatment 8.8528409E7 -1.37E7 -0.78 9.2778143E7 -1.15E7 -0.71 -1.0518 -0.9987 1402956 SPBio_001913 CC(N)C(O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P16 compound treatment 3.1291152E7 -7.09E7 -4.05 3.5280426E7 -6.9E7 -4.25 -5.8711 -0.9997 1040795 SPBio_001914 COc1cccc(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P17 compound treatment 1.1034382E8 8150000.0 0.47 1.06086756E8 1850000.0 0.11 0.4099 0.855 1010251 SPBio_001915 O=C(Nc1ccccc1)Nc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P18 compound treatment 9.0986545E7 -1.12E7 -0.64 9.4910459E7 -9330000.0 -0.57 -0.8595 -0.9985 2060417 SPBio_001916 CC(=C)C1Cc2c(O1)ccc(C(=O)O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P19 compound treatment 9.6004149E7 -6190000.0 -0.35 9.8542245E7 -5690000.0 -0.35 -0.4985 -1.0 2069279 SPBio_001917 CCC(C)C(NC)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P20 compound treatment 9.4710108E7 -7490000.0 -0.43 1.01987314E8 -2250000.0 -0.14 -0.4006 -0.8907 2060436 SPBio_001918 O=C(CCCCCCCCCCCCC1CCCC1)Nc2ccc(cc2)S(=O)(=O)c3ccc(NC(=O)CCCCCCCCCCCCC4CCCC4)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P21 compound treatment 6.7721105E7 -3.45E7 -1.97 6.8620919E7 -3.56E7 -2.2 -2.9456 -0.9985 2069262 SPBio_001919 COc1cc(/C=C/C=O)cc(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P22 compound treatment 9.2524652E7 -9670000.0 -0.55 9.6186536E7 -8050000.0 -0.5 -0.7418 -0.9986 2060448 SPBio_001920 COc1ccc2[C@H](O)[C@H](Cc3ccc(OC)c(OC)c3)COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P23 mock treatment 1.04094662E8 1900000.0 0.11 1.06065591E8 1830000.0 0.11 0.1564 0.9998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2163 P24 mock treatment 1.1172942E8 9530000.0 0.54 1.14470728E8 1.02E7 0.63 0.8313 0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A01 mock treatment 1.22735296E8 2.01E7 1.15 1.17863809E8 1.6E7 0.99 1.5097 0.9971 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A02 mock treatment 1.07984912E8 5360000.0 0.31 1.18996519E8 1.71E7 1.06 0.963 0.8763 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A03 compound treatment 1.01797288E8 -824000.0 -0.05 1.09230207E8 7350000.0 0.45 0.2872 0.6302 1026119 SPBio_001921 COc1ccc(C(=O)O)c(O)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A04 compound treatment 5.6694183E7 -4.59E7 -2.62 6.7604523E7 -3.43E7 -2.11 -3.3499 -0.9942 1164875 SPBio_001922 Nc1nc2[nH]nnc2c(=O)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A05 compound treatment 8.9526224E7 -1.31E7 -0.75 9.8107383E7 -3770000.0 -0.23 -0.6935 -0.885 2069278 SPBio_001923 Cc1cc(O)c(C=O)c(O)c1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A06 compound treatment 9.7248539E7 -5370000.0 -0.31 1.02130925E8 254000.0 0.02 -0.2061 -0.6702 923 SPBio_001924 NC(=O)NC1NC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A07 compound treatment 9.0046179E7 -1.26E7 -0.72 9.6124034E7 -5750000.0 -0.35 -0.7589 -0.947 3080393 SPBio_001925 COc1ccc(cc1)c2c(O)c3c(OC)c4CCC(C)(C)Oc4cc3oc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A08 compound treatment 9.2138741E7 -1.05E7 -0.6 9.8349421E7 -3530000.0 -0.22 -0.5774 -0.9059 692 SPBio_001926 CC(=O)Nc1nnc(s1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A09 compound treatment 8.2554318E7 -2.01E7 -1.15 8.6330245E7 -1.55E7 -0.96 -1.4886 -0.996 2069280 SPBio_001927 COc1cc(O)ccc1C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A10 compound treatment 8.7743127E7 -1.49E7 -0.85 9.094335E7 -1.09E7 -0.67 -1.0778 -0.9934 1714 SPBio_001928 CN(C)C(=N)NC(=N)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A11 compound treatment 7.2770217E7 -2.99E7 -1.71 8.3363592E7 -1.85E7 -1.14 -2.0133 -0.9809 2060335 SPBio_001929 Oc1ccc2C3Oc4cc5OCOc5cc4C3COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A12 compound treatment 7.4801968E7 -2.78E7 -1.59 8.5654541E7 -1.62E7 -1.0 -1.8313 -0.975 3221455 SPBio_001930 COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCc5cc(OC)c(OC)cc5C4Cc6ccc(OC)c(OC)c6)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A13 compound treatment 7.1519414E7 -3.11E7 -1.78 8.2200708E7 -1.97E7 -1.21 -2.1145 -0.9826 3198542 SPBio_001931 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(OC)c(c4cc(ccc4OC)c5cc(=O)c6c(OC)cc(OC)cc6o5)c3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A14 compound treatment 3.2995726E7 -6.96E7 -3.98 3.3145323E7 -6.87E7 -4.24 -5.8096 -0.9995 3064163 SPBio_001932 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A15 compound treatment 7.2395435E7 -3.02E7 -1.73 8.5947599E7 -1.59E7 -0.98 -1.9158 -0.9642 3080394 SPBio_001933 COc1cc(OC)c2c(=O)c(c(C)oc2c1OC)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A16 compound treatment 7.6114815E7 -2.65E7 -1.51 8.6353252E7 -1.55E7 -0.96 -1.7478 -0.9755 1000042 SPBio_001934 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A17 compound treatment 7.1354374E7 -3.13E7 -1.79 8.4045516E7 -1.78E7 -1.1 -2.0408 -0.9728 2060054 SPBio_001935 CC(=O)OC(OC(=O)C)c1c(OC(=O)C)cc(C)c2C(=O)Oc3c(C)c(OC(=O)C)c4C(=O)OC(OC(=O)C)c4c3Oc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A18 compound treatment 9.3742628E7 -8880000.0 -0.51 1.00815194E8 -1060000.0 -0.07 -0.4051 -0.7917 807 SPBio_001936 CCCc1ncc(C[n+]2ccccc2C)c(N)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A19 compound treatment 8.9274976E7 -1.33E7 -0.76 9.5003075E7 -6870000.0 -0.42 -0.839 -0.9615 3173626 SPBio_001937 CC(C)C(C)/C=C/C(C)C1CCC2C3=CC=C4C(C)(C)C(CCC4(C)C3CCC12C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A20 compound treatment 9.3822185E7 -8800000.0 -0.5 9.2538308E7 -9340000.0 -0.58 -0.7626 -0.9977 931 SPBio_001938 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A21 compound treatment 9.2587054E7 -1.0E7 -0.57 1.01308617E8 -568000.0 -0.04 -0.4303 -0.7489 1082584 SPBio_001939 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(=C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A22 compound treatment 1.06031271E8 3410000.0 0.19 1.02705558E8 829000.0 0.05 0.1739 0.8633 3068956 SPBio_001940 NC(=NS(=O)(=O)c1ccc(N)cc1)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A23 mock treatment 1.02957651E8 336000.0 0.02 1.07151408E8 5270000.0 0.33 0.2435 0.7476 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 A24 mock treatment 1.12748878E8 1.01E7 0.58 1.18743265E8 1.69E7 1.04 1.1444 0.9618 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B01 mock treatment 1.20298256E8 1.77E7 1.01 1.18726386E8 1.68E7 1.04 1.4488 0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B02 mock treatment 9.7299842E7 -5320000.0 -0.3 1.00995518E8 -881000.0 -0.05 -0.2535 -0.8204 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B03 compound treatment 9.5781485E7 -6840000.0 -0.39 9.5322137E7 -6550000.0 -0.4 -0.5621 -0.9999 683 SPBio_001941 Cc1ncc([N+](=O)[O-])n1CCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B04 compound treatment 8.7405943E7 -1.52E7 -0.87 9.0859942E7 -1.1E7 -0.68 -1.0951 -0.9925 735 SPBio_001942 NNC(=O)c1ccncc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B05 compound treatment 9.7230031E7 -5390000.0 -0.31 9.7647144E7 -4230000.0 -0.26 -0.4022 -0.9965 1449 SPBio_001943 CN1[C@@H](CCC1=O)c2cccnc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B06 compound treatment 9.3393405E7 -9230000.0 -0.53 9.4005179E7 -7870000.0 -0.49 -0.716 -0.9991 1008060 SPBio_001944 C1CCc2nnnn2CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B07 compound treatment 9.0831595E7 -1.18E7 -0.67 9.3035345E7 -8840000.0 -0.55 -0.8618 -0.9945 1402 SPBio_001945 CC[N+](C)(C)c1cccc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B08 compound treatment 8.2202794E7 -2.04E7 -1.17 8.571828E7 -1.62E7 -1.0 -1.5295 -0.9969 1480 SPBio_001946 Clc1ccc2oc(=O)[nH]c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B09 compound treatment 7.7912473E7 -2.47E7 -1.41 8.2097429E7 -1.98E7 -1.22 -1.8607 -0.9973 1029858 SPBio_001947 NC(=N)NC(=N)N1CCOCC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B10 compound treatment 8.0171476E7 -2.24E7 -1.28 7.6781697E7 -2.51E7 -1.55 -2.0011 -0.9957 1054660 SPBio_001948 Cc1ncc([N+](=O)[O-])n1CC(O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B11 compound treatment 6.9754629E7 -3.29E7 -1.88 7.3819195E7 -2.81E7 -1.73 -2.5512 -0.9992 678 SPBio_001949 NCC(CC(=O)O)c1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B12 compound treatment 7.685461E7 -2.58E7 -1.47 8.216318E7 -1.97E7 -1.22 -1.9006 -0.9954 869 SPBio_001950 CCC1(C)CC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B13 compound treatment 6.9434164E7 -3.32E7 -1.9 7.5843041E7 -2.6E7 -1.6 -2.4759 -0.9965 839 SPBio_001951 Nc1nc2n(COCCO)cnc2c(=O)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B14 compound treatment 7.6118215E7 -2.65E7 -1.51 7.8409642E7 -2.35E7 -1.45 -2.0939 -0.9997 997 SPBio_001952 NCc1ccc(cc1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B15 compound treatment 7.4319181E7 -2.83E7 -1.62 8.8044633E7 -1.38E7 -0.85 -1.7467 -0.9553 35 SPBio_001953 CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B16 compound treatment 7.4210726E7 -2.84E7 -1.62 7.9222384E7 -2.27E7 -1.4 -2.1356 -0.9972 399 SPBio_001954 Nc1nc2ccc(OC(F)(F)F)cc2s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B17 compound treatment 8.4473639E7 -1.81E7 -1.04 8.6196566E7 -1.57E7 -0.97 -1.4169 -0.9994 1090166 SPBio_001955 CN(C)c1c(C)n(C)n(c2ccccc2)c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B18 compound treatment 7.4942071E7 -2.77E7 -1.58 7.6749508E7 -2.51E7 -1.55 -2.2138 -0.9999 3173466 SPBio_001956 [O-][N+](=O)c1ccc(/C=N/N2CC(=O)NC2=O)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B19 compound treatment 8.4085732E7 -1.85E7 -1.06 8.5558188E7 -1.63E7 -1.01 -1.4604 -0.9997 3188940 SPBio_001957 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2[C@H]1C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B20 compound treatment 1.00942639E8 -1680000.0 -0.1 1.05149787E8 3270000.0 0.2 0.0748 0.3349 776 SPBio_001958 NNc1nncc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B21 compound treatment 8.9450991E7 -1.32E7 -0.75 9.0144888E7 -1.17E7 -0.72 -1.0436 -0.9998 1428 SPBio_001959 CC(C)NCC(O)COc1cccc2[nH]ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B22 compound treatment 8.5434412E7 -1.72E7 -0.98 8.9676823E7 -1.22E7 -0.75 -1.2263 -0.9913 3273 SPBio_001960 NNCCc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B23 mock treatment 8.9513119E7 -1.31E7 -0.75 9.1101766E7 -1.08E7 -0.66 -0.9994 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 B24 mock treatment 1.06316516E8 3700000.0 0.21 1.1186794E8 9990000.0 0.62 0.5848 0.8982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C01 mock treatment 1.01088578E8 -1530000.0 -0.09 1.02996266E8 1120000.0 0.07 -0.0131 -0.1179 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C02 mock treatment 9.4499047E7 -8120000.0 -0.46 9.6549187E7 -5330000.0 -0.33 -0.5605 -0.9856 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C03 compound treatment 8.6147726E7 -1.65E7 -0.94 8.8711636E7 -1.32E7 -0.81 -1.2396 -0.9973 2069342 SPBio_001961 COC1=CC(=O)C(=CC1=O)C(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C04 compound treatment 8.934144E7 -1.33E7 -0.76 9.1436645E7 -1.04E7 -0.64 -0.9917 -0.9966 2898 SPBio_001962 Cc1cc2CCCS(=O)(=O)c2cc1S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C05 compound treatment 9.1773988E7 -1.08E7 -0.62 8.9909034E7 -1.2E7 -0.74 -0.96 -0.9963 2060428 SPBio_001963 CCOC(=O)C(=O)C1(Oc2cc(OC)cc(OC)c2C(=O)C1c3ccccc3)C(=O)OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C06 compound treatment 9.1668246E7 -1.1E7 -0.63 9.0794748E7 -1.11E7 -0.68 -0.9257 -0.999 3188932 SPBio_001964 CCCCNc1ccc(cc1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C07 compound treatment 9.0651817E7 -1.2E7 -0.68 8.9758997E7 -1.21E7 -0.75 -1.0119 -0.999 966 SPBio_001965 OC[C@@H]1OC(=O)[C@@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C08 compound treatment 8.2277713E7 -2.03E7 -1.16 8.2535449E7 -1.93E7 -1.19 -1.6652 -0.9999 1131 SPBio_001966 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C09 compound treatment 3.4054044E7 -6.86E7 -3.92 3.3461677E7 -6.84E7 -4.22 -5.753 -0.9993 1000247 SPBio_001967 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)N(C)C)c5c(O)c6C(=O)c7c(O)cccc7C(=O)c6cc5[C@H]1C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C10 compound treatment 8.0761316E7 -2.19E7 -1.25 7.9222276E7 -2.27E7 -1.4 -1.8709 -0.9985 878 SPBio_001968 CC(=O)NS(=O)(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C11 compound treatment 8.0605122E7 -2.2E7 -1.26 8.4936359E7 -1.69E7 -1.04 -1.6281 -0.9957 1319 SPBio_001969 NCCCCN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C12 compound treatment 8.0286426E7 -2.23E7 -1.28 8.2186664E7 -1.97E7 -1.21 -1.7609 -0.9997 1507 SPBio_001970 CC(N)CCCC(C)(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C13 compound treatment 7.8240642E7 -2.44E7 -1.39 8.2195775E7 -1.97E7 -1.21 -1.8431 -0.9976 3173726 SPBio_001971 NNC(=O)c1ccncc1.Nc1ccc(C(=O)O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C14 compound treatment 7.7632318E7 -2.5E7 -1.43 8.2486922E7 -1.94E7 -1.2 -1.855 -0.9961 1175 SPBio_001972 Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C15 compound treatment 7.219071E7 -3.04E7 -1.74 7.8073027E7 -2.38E7 -1.47 -2.2673 -0.9964 914 SPBio_001973 OC[C@H]1O[C@@H](OC2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc24)[C@H](O)[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C16 compound treatment 7.3019208E7 -2.96E7 -1.69 7.9484529E7 -2.24E7 -1.38 -2.1723 -0.9949 1079 SPBio_001974 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C17 compound treatment 7.6812057E7 -2.58E7 -1.48 7.9445728E7 -2.24E7 -1.38 -2.0207 -0.9995 768 SPBio_001975 C[N+](C)(C)CCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C18 compound treatment 7.4437522E7 -2.82E7 -1.61 7.7787169E7 -2.41E7 -1.48 -2.189 -0.9992 3068957 SPBio_001976 OC[C@H]1O[C@H](CC1O)n2cc(I)c(=O)[nH]c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C19 compound treatment 8.2967826E7 -1.97E7 -1.12 8.1703729E7 -2.02E7 -1.24 -1.6735 -0.9987 3055573 SPBio_001977 OC[C@H]1OC([C@H](O)[C@@H]1O)n2cnc3c(=O)[nH]cnc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C20 compound treatment 8.4638668E7 -1.8E7 -1.03 8.2650155E7 -1.92E7 -1.19 -1.5648 -0.9975 3068958 SPBio_001978 CC(C)(CS)C(=O)N1CCC[C@@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C21 compound treatment 8.4812702E7 -1.78E7 -1.02 8.3353627E7 -1.85E7 -1.14 -1.5271 -0.9984 1193 SPBio_001979 CCOc1ccc(NC(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C22 compound treatment 9.2597335E7 -1.0E7 -0.57 8.5811895E7 -1.61E7 -0.99 -1.1053 -0.9662 82 SPBio_001980 Nc1cc(nc(N)[n+]1[O-])N2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C23 mock treatment 8.403655E7 -1.86E7 -1.06 8.2080571E7 -1.98E7 -1.22 -1.6139 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 C24 mock treatment 1.09633862E8 7010000.0 0.4 1.04309339E8 2430000.0 0.15 0.3894 0.9101 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D01 mock treatment 1.06727295E8 4110000.0 0.23 1.0309692E8 1220000.0 0.08 0.2191 0.8892 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D02 mock treatment 9.3760371E7 -8860000.0 -0.51 9.4840429E7 -7040000.0 -0.43 -0.6648 -0.997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D03 compound treatment 9.8994791E7 -3630000.0 -0.21 9.9676846E7 -2200000.0 -0.14 -0.2425 -0.9788 715 SPBio_001981 COc1c2ccoc2c(OC)c3oc(C)cc(=O)c13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D04 compound treatment 9.7605196E7 -5020000.0 -0.29 9.9630929E7 -2250000.0 -0.14 -0.3006 -0.9442 1262 SPBio_001982 NC[C@H]1CC[C@@H](CC1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D05 compound treatment 9.6636608E7 -5980000.0 -0.34 9.5845723E7 -6030000.0 -0.37 -0.5047 -0.9991 1002029 SPBio_001983 CN(C)C/C=C(/c1ccc(Br)cc1)\c2cccnc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D06 compound treatment 9.3113099E7 -9510000.0 -0.54 9.3887988E7 -7990000.0 -0.49 -0.7325 -0.9988 718 SPBio_001984 Cn1c(=O)n(C)c2ncn(CCO)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D07 compound treatment 9.0626757E7 -1.2E7 -0.69 8.8879474E7 -1.3E7 -0.8 -1.0513 -0.997 1451360 SPBio_001985 OC(C1CCNCC1)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D08 compound treatment 8.6297837E7 -1.63E7 -0.93 8.8787336E7 -1.31E7 -0.81 -1.2302 -0.9974 3069074 SPBio_001986 N[C@@H]1C[C@H]1c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D09 compound treatment 7.2349214E7 -3.03E7 -1.73 6.9175057E7 -3.27E7 -2.02 -2.6488 -0.9971 1921128 SPBio_001987 Cn1cnc([N+](=O)[O-])c1Sc2ncnc3nc[nH]c23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D10 compound treatment 8.4240354E7 -1.84E7 -1.05 8.2741239E7 -1.91E7 -1.18 -1.5769 -0.9983 3256 SPBio_001988 CCN(CCCc1ccccc1)CCCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D11 compound treatment 7.2640552E7 -3.0E7 -1.71 7.2730721E7 -2.91E7 -1.8 -2.482 -0.9997 3069004 SPBio_001989 C[C@@]12CC[C@H]3[C@@H](CCC4=CCCC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D12 compound treatment 8.1980129E7 -2.06E7 -1.18 8.500216E7 -1.69E7 -1.04 -1.5697 -0.998 3069075 SPBio_001990 OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D13 compound treatment 8.1123123E7 -2.15E7 -1.23 8.8749215E7 -1.31E7 -0.81 -1.441 -0.9795 3060090 SPBio_001991 NC(=N)N/N=C/c1c(Cl)cccc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D14 compound treatment 7.9220405E7 -2.34E7 -1.34 8.81175E7 -1.38E7 -0.85 -1.5454 -0.9758 780 SPBio_001992 CC(C)NNC(=O)c1ccncc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D15 compound treatment 2.8208129E7 -7.44E7 -4.25 2.7481476E7 -7.44E7 -4.59 -6.2499 -0.9993 2038 SPBio_001993 CCN(CC)C(=S)SSC(=S)N(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D16 compound treatment 8.5606457E7 -1.7E7 -0.97 8.9480015E7 -1.24E7 -0.76 -1.228 -0.9929 1256 SPBio_001994 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D17 compound treatment 8.3769411E7 -1.89E7 -1.08 8.4411788E7 -1.75E7 -1.08 -1.5231 -1.0 2060486 SPBio_001995 CC(=O)Oc1ccccc1C(=O)Oc2ccccc2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D18 compound treatment 8.9725805E7 -1.29E7 -0.74 8.8214835E7 -1.37E7 -0.84 -1.1166 -0.9978 741 SPBio_001996 Cc1ccccc1OCC(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D19 compound treatment 9.0133694E7 -1.25E7 -0.71 8.7324067E7 -1.46E7 -0.9 -1.139 -0.9936 1434 SPBio_001997 CN1CCN2C(C1)c3ccccc3Cc4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D20 compound treatment 9.27131E7 -9910000.0 -0.57 8.7194761E7 -1.47E7 -0.91 -1.0404 -0.9745 1018627 SPBio_001998 NC(=N)NC(=N)NCCc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D21 compound treatment 4.0402255E7 -6.22E7 -3.56 4.0153884E7 -6.17E7 -3.8 -5.2048 -0.9994 440 SPBio_001999 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D22 compound treatment 9.6306363E7 -6320000.0 -0.36 8.9533423E7 -1.23E7 -0.76 -0.7932 -0.9419 1086 SPBio_002000 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(c1)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D23 mock treatment 9.1475201E7 -1.11E7 -0.64 8.8466958E7 -1.34E7 -0.83 -1.0349 -0.9917 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 D24 mock treatment 1.02124304E8 -497000.0 -0.03 9.5475716E7 -6400000.0 -0.39 -0.2991 -0.7561 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E01 mock treatment 1.00764068E8 -1860000.0 -0.11 9.6659172E7 -5220000.0 -0.32 -0.3025 -0.8931 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E02 mock treatment 1.02773772E8 152000.0 0.01 9.2993352E7 -8880000.0 -0.55 -0.3811 -0.6958 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E03 compound treatment 1.0268339E8 61900.0 0.0 1.00574657E8 -1300000.0 -0.08 -0.0543 -0.6753 939 SPBio_002001 Cc1cccc(Nc2ccccc2C(=O)O)c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E04 compound treatment 9.7416898E7 -5200000.0 -0.3 9.6826373E7 -5050000.0 -0.31 -0.4305 -0.9997 944 SPBio_002002 Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E05 compound treatment 8.8568732E7 -1.41E7 -0.8 8.5638257E7 -1.62E7 -1.0 -1.2757 -0.994 1668673 SPBio_002003 Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E06 compound treatment 9.1993714E7 -1.06E7 -0.61 9.0159035E7 -1.17E7 -0.72 -0.9402 -0.9963 3060 SPBio_002004 CC(C)(CO)[C@@H](O)C(=O)NCCCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E07 compound treatment 9.3094976E7 -9530000.0 -0.54 8.5626822E7 -1.62E7 -1.0 -1.0933 -0.9589 944 SPBio_002005 Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E08 compound treatment 9.1022736E7 -1.16E7 -0.66 8.5844561E7 -1.6E7 -0.99 -1.1675 -0.9811 1159 SPBio_002006 Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E09 compound treatment 8.8762815E7 -1.39E7 -0.79 8.6632303E7 -1.52E7 -0.94 -1.2245 -0.9964 2060488 SPBio_002007 CC(=CCC[C@@](C)(O)C=C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E10 compound treatment 8.2207925E7 -2.04E7 -1.17 7.9221018E7 -2.27E7 -1.4 -1.8125 -0.996 3188934 SPBio_002008 C[C@@]12CC[C@H]3[C@@H](CCC4=C3CCC(=O)C4)[C@@H]2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E11 compound treatment 8.2369855E7 -2.03E7 -1.16 8.4764907E7 -1.71E7 -1.05 -1.5643 -0.9989 3198543 SPBio_002009 [Na+].Oc1ccccc1C(=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E12 compound treatment 8.7651651E7 -1.5E7 -0.86 9.1728678E7 -1.01E7 -0.63 -1.0473 -0.9882 1433 SPBio_002010 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E13 compound treatment 8.035814E7 -2.23E7 -1.27 8.4321773E7 -1.76E7 -1.08 -1.6649 -0.9968 1603 SPBio_002011 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E14 compound treatment 8.3506461E7 -1.91E7 -1.09 8.178539E7 -2.01E7 -1.24 -1.6482 -0.998 3068961 SPBio_002012 CN/C(=N/C#N)/NCCSCC1N=CN=C1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E15 compound treatment 8.3599198E7 -1.9E7 -1.09 8.4985459E7 -1.69E7 -1.04 -1.505 -0.9998 870 SPBio_002013 OC(=O)/C(=C/c1ccc(O)cc1)/C#N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E16 compound treatment 8.8532027E7 -1.41E7 -0.81 8.494929E7 -1.69E7 -1.04 -1.3072 -0.9918 1432 SPBio_002014 CN(C)CCOC(C)(c1ccccc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E17 compound treatment 6.0015829E7 -4.26E7 -2.43 5.6516934E7 -4.54E7 -2.8 -3.6989 -0.9976 3055218 SPBio_002015 OCC(O)[C@H]1OC(=O)C(=C1O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E18 compound treatment 9.0895217E7 -1.17E7 -0.67 8.6545762E7 -1.53E7 -0.95 -1.1421 -0.9858 1000260 SPBio_002016 CC[C@H](CO)NCCN[C@H](CC)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E19 compound treatment 9.0525818E7 -1.21E7 -0.69 8.8130286E7 -1.37E7 -0.85 -1.088 -0.9949 3198544 SPBio_002017 CC([C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E20 compound treatment 9.319741E7 -9420000.0 -0.54 8.8234662E7 -1.36E7 -0.84 -0.9755 -0.9768 1108 SPBio_002018 Cc1cc(=O)n(c2ccccc2)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E21 compound treatment 8.8434444E7 -1.42E7 -0.81 8.6372922E7 -1.55E7 -0.96 -1.2491 -0.9967 3471107 SPBio_002019 NC(=O)c1cc[n+](CC2=C(N3C(SC2)C(NC(=O)C(c4ccccc4)S(=O)(=O)O)C3=O)C(=O)O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E22 compound treatment 7.9726909E7 -2.29E7 -1.31 7.763694E7 -2.42E7 -1.49 -1.9818 -0.9978 1079457 SPBio_002020 Cc1c(O)c(=O)n(c2ccccc2)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E23 mock treatment 9.5576385E7 -7050000.0 -0.4 8.7084042E7 -1.48E7 -0.91 -0.9295 -0.9325 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 E24 mock treatment 9.9109891E7 -3510000.0 -0.2 9.3165037E7 -8710000.0 -0.54 -0.5216 -0.9099 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F01 mock treatment 1.09149548E8 6530000.0 0.37 1.01171058E8 -706000.0 -0.04 0.2331 0.6205 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F02 mock treatment 1.00572298E8 -2050000.0 -0.12 1.0211124E8 234000.0 0.01 -0.0726 -0.6152 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F03 compound treatment 5.9852226E7 -4.28E7 -2.44 6.4518405E7 -3.74E7 -2.3 -3.3568 -0.9996 899 SPBio_002021 CN1CCc2cccc-3c2[C@H]1Cc4ccc(O)c(O)c43 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F04 compound treatment 9.4460496E7 -8160000.0 -0.47 9.6106098E7 -5770000.0 -0.36 -0.5813 -0.9911 1081 SPBio_002022 Cc1c(N)c(=O)n(c2ccccc2)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F05 compound treatment 8.7584229E7 -1.5E7 -0.86 9.2190206E7 -9690000.0 -0.6 -1.0299 -0.9842 885 SPBio_002023 Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F06 compound treatment 9.1961801E7 -1.07E7 -0.61 9.2274273E7 -9600000.0 -0.59 -0.8493 -0.9999 1274 SPBio_002024 C1CN2C[C@@H](N=C2S1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F07 compound treatment 8.8202761E7 -1.44E7 -0.82 8.750171E7 -1.44E7 -0.89 -1.2093 -0.9993 3326 SPBio_002025 CN1CCC(=C2c3ccccc3C=Cc4ccccc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F08 compound treatment 8.9752811E7 -1.29E7 -0.74 8.7390865E7 -1.45E7 -0.89 -1.1515 -0.9954 719 SPBio_002026 CN(CC#C)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F09 compound treatment 8.7828232E7 -1.48E7 -0.85 8.5286882E7 -1.66E7 -1.02 -1.3209 -0.9955 3177110 SPBio_002027 NC(=Nc1nc(CSCC/C(=N/S(=O)(=O)N)/N)cs1)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F10 compound treatment 8.4343992E7 -1.83E7 -1.04 8.7575287E7 -1.43E7 -0.88 -1.362 -0.9964 1062 SPBio_002028 COc1ccccc1OCC(O)COC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F11 compound treatment 8.2504564E7 -2.01E7 -1.15 8.4584322E7 -1.73E7 -1.07 -1.5667 -0.9993 3189048 SPBio_002029 C[C@@]12CC[C@H]3[C@@H](CCC4=Cc5oncc5C[C@]34C)[C@@H]2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F12 compound treatment 8.1206739E7 -2.14E7 -1.22 8.557618E7 -1.63E7 -1.0 -1.5759 -0.9952 3189063 SPBio_002030 C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)/c2csc(N)n2)C(=O)N1S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F13 compound treatment 7.7899934E7 -2.47E7 -1.41 7.7169836E7 -2.47E7 -1.52 -2.076 -0.9993 3169 SPBio_002031 CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F14 compound treatment 8.3142114E7 -1.95E7 -1.11 8.8612168E7 -1.33E7 -0.82 -1.3654 -0.9885 1337 SPBio_002032 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F15 compound treatment 8.6782351E7 -1.58E7 -0.91 8.8506974E7 -1.34E7 -0.82 -1.2229 -0.9989 3189049 SPBio_002033 C[N+]1([O-])[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F16 compound treatment 8.1930448E7 -2.07E7 -1.18 7.8832297E7 -2.3E7 -1.42 -1.8406 -0.9958 724 SPBio_002034 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F17 compound treatment 8.5200408E7 -1.74E7 -1.0 8.6614362E7 -1.53E7 -0.94 -1.3693 -0.9996 1386 SPBio_002035 CN1CC(c2ccccc2)c3cccc(N)c3C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F18 compound treatment 9.0241294E7 -1.24E7 -0.71 9.088108E7 -1.1E7 -0.68 -0.9796 -0.9998 3045683 SPBio_002036 C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F19 compound treatment 9.3011072E7 -9610000.0 -0.55 9.3058371E7 -8820000.0 -0.54 -0.7728 -1.0 907387 SPBio_002037 C[C@@]1(N[C@@H]2Cc3ccccc31)c4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F20 compound treatment 8.9147778E7 -1.35E7 -0.77 8.7655456E7 -1.42E7 -0.88 -1.1644 -0.9979 1428839 SPBio_002038 C(Nc1ncnc2[nH]cnc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F21 compound treatment 9.0380609E7 -1.22E7 -0.7 8.8519755E7 -1.34E7 -0.82 -1.0769 -0.9967 3069006 SPBio_002039 CC(=O)CC(c1ccc(cc1)[N+](=O)[O-])c2c(O)c3ccccc3oc2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F22 compound treatment 8.5014481E7 -1.76E7 -1.01 8.2698746E7 -1.92E7 -1.18 -1.5475 -0.9968 198 SPBio_002040 CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F23 mock treatment 9.387981E7 -8740000.0 -0.5 8.3138364E7 -1.87E7 -1.16 -1.17 -0.9297 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 F24 mock treatment 9.4289914E7 -8330000.0 -0.48 9.5156266E7 -6720000.0 -0.41 -0.6296 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G01 mock treatment 1.02433215E8 -188000.0 -0.01 9.7980777E7 -3900000.0 -0.24 -0.1774 -0.738 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G02 mock treatment 1.08007265E8 5390000.0 0.31 9.9700841E7 -2180000.0 -0.13 0.1228 0.3658 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G03 compound treatment 1.06323351E8 3700000.0 0.21 1.06960114E8 5080000.0 0.31 0.3712 0.9817 3058484 SPBio_002041 CC(CCC(=O)O)[C@H]1CCC2C3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G04 compound treatment 1.05386927E8 2770000.0 0.16 1.0677592E8 4900000.0 0.3 0.3253 0.9544 3188935 SPBio_002042 OC[C@@H](NC(=O)C(Cl)Cl)[C@@H](O)c1ccc(cc1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G05 compound treatment 7.099633E7 -3.16E7 -1.81 7.77532E7 -2.41E7 -1.49 -2.3295 -0.9953 2069269 SPBio_002043 COC(=O)CCC(C)C1CCC2C3CCC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G06 compound treatment 9.662115E7 -6000000.0 -0.34 9.9591268E7 -2290000.0 -0.14 -0.3421 -0.9228 2702 SPBio_002044 COc1cc(C)nn1c2nc(C)cc(OC)n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G07 compound treatment 9.5241637E7 -7380000.0 -0.42 9.9530186E7 -2350000.0 -0.14 -0.4005 -0.8983 3059164 SPBio_002045 CC(C)CCCC(C)C1CCC2C3CC[C@H]4CC(=O)CC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G08 compound treatment 9.3381334E7 -9240000.0 -0.53 9.4484811E7 -7390000.0 -0.46 -0.6956 -0.9973 697 SPBio_002046 Cn1c(=O)n(C)c2ncn(CC(O)CO)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G09 compound treatment 4.5437386E7 -5.72E7 -3.27 4.0471374E7 -6.14E7 -3.79 -4.9875 -0.9973 2060111 SPBio_002047 COc1cc(O)c(cc1O)C(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G10 compound treatment 7.0433464E7 -3.22E7 -1.84 7.1449548E7 -3.04E7 -1.88 -2.627 -1.0 1061 SPBio_002048 Nc1nc(N)c2nc(c(N)nc2n1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G11 compound treatment 8.7904254E7 -1.47E7 -0.84 9.59264E7 -5950000.0 -0.37 -0.8541 -0.9308 2069324 SPBio_002049 COc1cc(/C=C/C(=O)O)cc(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G12 compound treatment 8.7950381E7 -1.47E7 -0.84 9.1544577E7 -1.03E7 -0.64 -1.0432 -0.9908 1186 SPBio_002050 Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G13 compound treatment 8.6550444E7 -1.61E7 -0.92 9.3695839E7 -8180000.0 -0.5 -1.0061 -0.9601 1029168 SPBio_002051 CC(=O)c1ccc[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G14 compound treatment 9.0186254E7 -1.24E7 -0.71 9.7452139E7 -4420000.0 -0.27 -0.6954 -0.9135 3188936 SPBio_002052 COC1CC(O[C@@H]2[C@H](C)[C@H](OC3OC(C)CC(C3OC(=O)C)N(C)C)[C@H](C)CC4(CO4)C(=O)[C@@H](C)C(OC(=O)C)[C@H](C)[C@H](C)OC(=O)[C@@H]2C)OC(C)C1OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G15 compound treatment 7.0558096E7 -3.21E7 -1.83 7.5796826E7 -2.61E7 -1.61 -2.4325 -0.9979 2060336 SPBio_002053 CCOc1cccc(c1)C(=O)c2ccc(O)c(O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G16 compound treatment 6.3152651E7 -3.95E7 -2.26 6.3480013E7 -3.84E7 -2.37 -3.2687 -0.9997 1259 SPBio_002054 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G17 compound treatment 9.3679471E7 -8940000.0 -0.51 1.01177299E8 -699000.0 -0.04 -0.3919 -0.764 2060244 SPBio_002055 COC1=CC(=O)OC(CCc2ccc(OC)c(OC)c2)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G18 compound treatment 9.5627764E7 -6990000.0 -0.4 9.8766333E7 -3110000.0 -0.19 -0.4182 -0.9434 1270 SPBio_002056 C[N+](C)(C)CCCCCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G19 compound treatment 9.3682805E7 -8940000.0 -0.51 9.5098222E7 -6780000.0 -0.42 -0.6567 -0.995 2060081 SPBio_002057 CC(=CCc1c(O)cc(C)oc1=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G20 compound treatment 9.7761589E7 -4860000.0 -0.28 9.7681917E7 -4190000.0 -0.26 -0.3792 -0.9994 1518 SPBio_002058 OC(=O)c1cc(ccc1O)c2ccc(F)cc2F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G21 compound treatment 7.0577421E7 -3.2E7 -1.83 7.2545355E7 -2.93E7 -1.81 -2.5735 -1.0 1091 SPBio_002059 CCc1cn(C2OCC(O)C2CO)c(=O)nc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G22 compound treatment 5.7050822E7 -4.56E7 -2.6 7.0140072E7 -3.17E7 -1.96 -3.2249 -0.9901 1313 SPBio_002060 Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G23 mock treatment 9.7170165E7 -5450000.0 -0.31 9.5313585E7 -6560000.0 -0.4 -0.5064 -0.9917 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 G24 mock treatment 1.0315375E8 532000.0 0.03 1.05886944E8 4010000.0 0.25 0.1963 0.7882 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H01 mock treatment 1.08348648E8 5730000.0 0.33 1.01239049E8 -638000.0 -0.04 0.2037 0.6177 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H02 mock treatment 1.02762873E8 141000.0 0.01 1.0299501E8 1120000.0 0.07 0.0545 0.7846 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H03 compound treatment 1.04647097E8 2030000.0 0.12 1.06101312E8 4220000.0 0.26 0.266 0.9334 929 SPBio_002061 Oc1ccc2C[C@H]3N(CC=C)CC[C@]4([C@H]5Oc1c24)[C@@]3(O)CCC5=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H04 compound treatment 1.00420976E8 -2200000.0 -0.13 1.02321539E8 445000.0 0.03 -0.0695 -0.5403 1535 SPBio_002062 COc1ccc(OC)c(c1)C(O)CNC(=O)CN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H05 compound treatment 9.660546E7 -6020000.0 -0.34 9.897039E7 -2910000.0 -0.18 -0.3698 -0.9538 918 SPBio_002063 CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H06 compound treatment 9.8209414E7 -4410000.0 -0.25 1.0026408E8 -1610000.0 -0.1 -0.2486 -0.9172 370 SPBio_002064 O=C1N(C2CCC(=O)NC2=O)C(=O)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H07 compound treatment 1.00139271E8 -2480000.0 -0.14 1.0153174E8 -345000.0 -0.02 -0.1153 -0.8041 757 SPBio_002065 OC(=O)c1cn(C2CC2)c3cc(N4CCNCC4)c(F)cc3c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H08 compound treatment 9.2124123E7 -1.05E7 -0.6 9.4132632E7 -7740000.0 -0.48 -0.7618 -0.9936 1266 SPBio_002066 CCn1cc(C(=O)O)c(=O)c2cc3OCOc3cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H09 compound treatment 9.4184892E7 -8440000.0 -0.48 9.5265629E7 -6610000.0 -0.41 -0.6291 -0.9965 1092 SPBio_002067 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H10 compound treatment 9.3958426E7 -8660000.0 -0.5 9.6605723E7 -5270000.0 -0.32 -0.5798 -0.9791 1298 SPBio_002068 CS(=O)(=O)Nc1ccc(cc1Oc2ccccc2)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H11 compound treatment 9.0259496E7 -1.24E7 -0.71 9.4180921E7 -7700000.0 -0.47 -0.835 -0.9812 1261 SPBio_002069 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H12 compound treatment 8.7604711E7 -1.5E7 -0.86 9.7183328E7 -4690000.0 -0.29 -0.8114 -0.8959 1482 SPBio_002070 CN1CCc2cc3OCOc3cc2C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H13 compound treatment 8.973586E7 -1.29E7 -0.74 9.4450049E7 -7430000.0 -0.46 -0.8445 -0.9738 3189051 SPBio_002071 Oc1ccc2C[C@H]3N(CC4CC4)CC[C@]5([C@H]6Oc1c25)[C@@]3(O)CCC6=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H14 compound treatment 9.0278039E7 -1.23E7 -0.71 9.6048847E7 -5830000.0 -0.36 -0.7529 -0.951 1331 SPBio_002072 CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H15 compound treatment 9.1784865E7 -1.08E7 -0.62 9.7204123E7 -4670000.0 -0.29 -0.6416 -0.9393 1207 SPBio_002073 CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H16 compound treatment 9.453086E7 -8090000.0 -0.46 9.8141997E7 -3730000.0 -0.23 -0.4897 -0.9481 3189174 SPBio_002074 C[C@H](N)[C@H](O)c1cccc(O)c1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H17 compound treatment 9.4722865E7 -7900000.0 -0.45 9.850315E7 -3370000.0 -0.21 -0.4662 -0.9381 1027 SPBio_002075 O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CCC6)c54 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H18 compound treatment 9.6854349E7 -5770000.0 -0.33 1.02085891E8 209000.0 0.01 -0.2239 -0.6789 1523 SPBio_002076 CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H19 compound treatment 9.7740346E7 -4880000.0 -0.28 1.02494854E8 618000.0 0.04 -0.1703 -0.6049 2241 SPBio_002077 COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H20 compound treatment 9.5140597E7 -7480000.0 -0.43 9.6927734E7 -4950000.0 -0.31 -0.518 -0.9863 1436 SPBio_002078 CCCNC(C)C(=O)Nc1ccccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H21 compound treatment 3.9561782E7 -6.31E7 -3.6 3.7714938E7 -6.42E7 -3.96 -5.3451 -0.9989 1002008 SPBio_002079 C[C@@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]2C[C@@H](O)[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H22 compound treatment 2.8042543E7 -7.46E7 -4.26 2.8034611E7 -7.38E7 -4.55 -6.2325 -0.9995 383 SPBio_002080 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccccc5cc4Cn3c2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H23 mock treatment 1.0204487E8 -577000.0 -0.03 1.04276968E8 2400000.0 0.15 0.0813 0.5365 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 H24 mock treatment 1.06382826E8 3760000.0 0.21 1.00855964E8 -1020000.0 -0.06 0.1075 0.48 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I01 mock treatment 1.06154679E8 3530000.0 0.2 1.02532213E8 655000.0 0.04 0.1714 0.8321 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I02 mock treatment 1.05820166E8 3200000.0 0.18 9.8604378E7 -3270000.0 -0.2 -0.0134 -0.0491 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I03 compound treatment 1.04316011E8 1690000.0 0.1 1.03956767E8 2080000.0 0.13 0.1591 0.9904 3080395 SPBio_002081 CC(C)CCCC(C)C1CCC2C3CC[C@H]4CCCC[C@]4(C)C3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I04 compound treatment 1.03523613E8 902000.0 0.05 1.07144202E8 5270000.0 0.32 0.2661 0.8093 779 SPBio_002082 CCN(CC)CCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I05 compound treatment 9.7826428E7 -4800000.0 -0.27 9.9435893E7 -2440000.0 -0.15 -0.3002 -0.9601 3526 SPBio_002083 Oc1ccc2ccc(=O)oc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I06 compound treatment 9.8845298E7 -3780000.0 -0.22 9.843866E7 -3440000.0 -0.21 -0.3025 -1.0 2847 SPBio_002084 CC(C)c1cc(OC(=O)C)c(C)cc1OCCN(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I07 compound treatment 7.7918217E7 -2.47E7 -1.41 8.0250913E7 -2.16E7 -1.33 -1.9409 -0.9996 3198545 SPBio_002085 Oc1ccc(/C=C/C=O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I08 compound treatment 9.4032895E7 -8590000.0 -0.49 9.8904021E7 -2970000.0 -0.18 -0.4767 -0.9098 3068964 SPBio_002086 NCCc1cc[nH]n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I09 compound treatment 7.9171613E7 -2.34E7 -1.34 7.4150984E7 -2.77E7 -1.71 -2.1562 -0.9928 1008535 SPBio_002087 COc1cccc(C=O)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I10 compound treatment 8.9883164E7 -1.27E7 -0.73 9.164422E7 -1.02E7 -0.63 -0.9608 -0.9974 1268 SPBio_002088 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3cc(C)on3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I11 compound treatment 9.0566415E7 -1.21E7 -0.69 9.4975496E7 -6900000.0 -0.43 -0.788 -0.9732 762 SPBio_002089 COc1cccc(OC)c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I12 compound treatment 8.8736548E7 -1.39E7 -0.79 9.3708377E7 -8170000.0 -0.5 -0.9172 -0.9759 1000165 SPBio_002090 COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I13 compound treatment 8.8992336E7 -1.36E7 -0.78 9.4708465E7 -7170000.0 -0.44 -0.8632 -0.9639 3055245 SPBio_002091 CCC[C@@H]1CCCCN1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I14 compound treatment 9.1795223E7 -1.08E7 -0.62 9.5620156E7 -6260000.0 -0.39 -0.7102 -0.9741 1083 SPBio_002092 C(C1=NCCN1)c2cccc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I15 compound treatment 4.9601859E7 -5.3E7 -3.03 3.9626219E7 -6.23E7 -3.84 -4.856 -0.9932 1496 SPBio_002093 CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I16 compound treatment 9.3726851E7 -8890000.0 -0.51 1.01804925E8 -71800.0 0.0 -0.3626 -0.7132 1821 SPBio_002094 Clc1ccccc1CN2CCc3sccc3C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I17 compound treatment 9.4420663E7 -8200000.0 -0.47 9.798088E7 -3900000.0 -0.24 -0.5012 -0.9518 1280 SPBio_002095 NCCNC(=O)c1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I18 compound treatment 9.8717992E7 -3900000.0 -0.22 1.03533248E8 1660000.0 0.1 -0.0855 -0.3487 819 SPBio_002096 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I19 compound treatment 9.8290269E7 -4330000.0 -0.25 9.889935E7 -2980000.0 -0.18 -0.3048 -0.9892 1440 SPBio_002097 COc1ccc2cc(CCC(=O)C)ccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I20 compound treatment 9.6327012E7 -6290000.0 -0.36 9.7503348E7 -4370000.0 -0.27 -0.445 -0.9899 3188937 SPBio_002098 CCC(C)(CN(C)C)OC(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I21 compound treatment 8.3102309E7 -1.95E7 -1.12 8.6265463E7 -1.56E7 -0.96 -1.4693 -0.9973 1069 SPBio_002099 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I22 compound treatment 9.2267963E7 -1.04E7 -0.59 9.3526187E7 -8350000.0 -0.51 -0.7824 -0.9976 362 SPBio_002100 CCN(CC)CC(=O)Nc1c(C)cccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I23 mock treatment 9.9650766E7 -2970000.0 -0.17 9.5246076E7 -6630000.0 -0.41 -0.4091 -0.9243 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 I24 mock treatment 1.05257921E8 2640000.0 0.15 1.01911852E8 35100.0 0.0 0.1081 0.7172 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J01 mock treatment 1.08174258E8 5550000.0 0.32 1.0222027E8 344000.0 0.02 0.2394 0.7526 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J02 mock treatment 1.06230477E8 3610000.0 0.21 9.9722433E7 -2150000.0 -0.13 0.0519 0.2118 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J03 compound treatment 1.04888878E8 2270000.0 0.13 1.0293778E8 1060000.0 0.07 0.1379 0.9499 1000273 SPBio_002101 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J04 compound treatment 1.01858441E8 -763000.0 -0.04 1.01921215E8 44500.0 0.0 -0.0289 -0.6614 1068 SPBio_002102 CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(CN(C)C)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J05 compound treatment 9.8102122E7 -4520000.0 -0.26 9.9871991E7 -2000000.0 -0.12 -0.27 -0.943 3069040 SPBio_002103 CNCC(O)c1ccc(O)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J06 compound treatment 9.9613615E7 -3010000.0 -0.17 1.01838449E8 -38300.0 0.0 -0.1232 -0.7167 3069077 SPBio_002104 OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J07 compound treatment 8.7647249E7 -1.5E7 -0.86 9.1696202E7 -1.02E7 -0.63 -1.0489 -0.9884 3189053 SPBio_002105 CC(C)CCC(=O)O.C[C@]12CCC[C@H]2[C@H]3[C@H](CC1=O)[C@@]4(C)CCC(=O)C[C@H]4CC3=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J08 compound treatment 9.5904489E7 -6720000.0 -0.38 9.7039006E7 -4840000.0 -0.3 -0.4823 -0.9922 41 SPBio_002106 OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J09 compound treatment 9.4180896E7 -8440000.0 -0.48 9.3806221E7 -8070000.0 -0.5 -0.6929 -0.9999 1610 SPBio_002107 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J10 compound treatment 8.9574524E7 -1.3E7 -0.75 9.2022804E7 -9850000.0 -0.61 -0.9568 -0.9948 752 SPBio_002108 CC1CCc2cc(F)cc3c(=O)c(cn1c23)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J11 compound treatment 8.1621029E7 -2.1E7 -1.2 7.5901411E7 -2.6E7 -1.6 -1.9809 -0.9899 1465 SPBio_002109 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J12 compound treatment 9.2049918E7 -1.06E7 -0.6 9.2136719E7 -9740000.0 -0.6 -0.8518 -1.0 1258696 SPBio_002110 Cc1c(Cl)cccc1Nc2ccccc2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J13 compound treatment 7.0705213E7 -3.19E7 -1.82 6.8276449E7 -3.36E7 -2.07 -2.7544 -0.998 1387 SPBio_002111 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J14 compound treatment 9.303054E7 -9590000.0 -0.55 9.6868786E7 -5010000.0 -0.31 -0.6059 -0.9631 1123 SPBio_002112 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J15 compound treatment 1.07216448E8 4590000.0 0.26 1.08743545E8 6870000.0 0.42 0.485 0.9736 3487389 SPBio_002113 Clc1ccc(C(Cn2ccnc2)OCc3c(Cl)cccc3Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J16 compound treatment 9.2752911E7 -9870000.0 -0.56 9.6147262E7 -5730000.0 -0.35 -0.6485 -0.9746 3189175 SPBio_002114 COC1=CC(=O)O[C@H](C1)/C=C/c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J17 compound treatment 8.4194232E7 -1.84E7 -1.05 8.5097681E7 -1.68E7 -1.03 -1.476 -1.0 3189054 SPBio_002115 CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)[C@H]13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J18 compound treatment 9.0035766E7 -1.26E7 -0.72 9.7215031E7 -4660000.0 -0.29 -0.7118 -0.919 1201 SPBio_002116 COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J19 compound treatment 9.439496E7 -8230000.0 -0.47 9.4167082E7 -7710000.0 -0.48 -0.6685 -1.0 786 SPBio_002117 CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J20 compound treatment 9.8589642E7 -4030000.0 -0.23 1.02736166E8 859000.0 0.05 -0.1255 -0.5307 734 SPBio_002118 CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J21 compound treatment 3.2130423E7 -7.05E7 -4.03 3.1512941E7 -7.04E7 -4.34 -5.9157 -0.9993 1000246 SPBio_002119 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J22 compound treatment 4.6098845E7 -5.65E7 -3.23 4.8183868E7 -5.37E7 -3.31 -4.6246 -0.9999 1281686 SPBio_002120 COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J23 mock treatment 1.06791552E8 4170000.0 0.24 1.10739188E8 8860000.0 0.55 0.5548 0.9309 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 J24 mock treatment 1.01742385E8 -879000.0 -0.05 1.03428743E8 1550000.0 0.1 0.0321 0.2973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K01 mock treatment 1.04876483E8 2260000.0 0.13 9.9884421E7 -1990000.0 -0.12 0.0043 0.0241 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K02 mock treatment 9.4558457E7 -8060000.0 -0.46 9.5405581E7 -6470000.0 -0.4 -0.6079 -0.9974 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K03 compound treatment 1.01918573E8 -703000.0 -0.04 9.6811794E7 -5060000.0 -0.31 -0.2492 -0.7916 2060334 SPBio_002121 C[C@H]1[C@@H](O)C[C@H]2[C@@H]1[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)OC=C2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K04 compound treatment 9.7357742E7 -5260000.0 -0.3 9.7199147E7 -4680000.0 -0.29 -0.4166 -0.9998 1010605 SPBio_002122 COP(=O)(OC)C(O)C(Cl)(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K05 compound treatment 9.1539796E7 -1.11E7 -0.63 9.1795576E7 -1.01E7 -0.62 -0.8873 -1.0 2060497 SPBio_002123 CC(C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C#N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K06 compound treatment 9.1438983E7 -1.12E7 -0.64 9.2557617E7 -9320000.0 -0.57 -0.8581 -0.9986 1019 SPBio_002124 NC(=O)N1c2ccccc2C=Cc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K07 compound treatment 9.7651245E7 -4970000.0 -0.28 9.8628482E7 -3250000.0 -0.2 -0.3424 -0.9853 1765 SPBio_002125 CC1(C)NC(=O)N(C1=O)c2ccc([N+](=O)[O-])c(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K08 compound treatment 8.1437002E7 -2.12E7 -1.21 8.1498106E7 -2.04E7 -1.26 -1.7444 -0.9998 1401 SPBio_002126 CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K09 compound treatment 9.0049196E7 -1.26E7 -0.72 4.5175848E7 -5.67E7 -3.5 -2.9795 -0.835 3057756 SPBio_002127 C1CCN2C[C@H]3C[C@@H](CN4CCCC[C@H]34)[C@@H]2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K10 compound treatment 9.2728681E7 -9890000.0 -0.57 9.1556511E7 -1.03E7 -0.64 -0.8496 -0.9983 939 SPBio_002128 Cc1cccc(Nc2ccccc2C(=O)O)c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K11 compound treatment 9.3713124E7 -8910000.0 -0.51 9.178971E7 -1.01E7 -0.62 -0.7997 -0.9951 3198546 SPBio_002129 CC(=CCC/C(=C/COC(=O)\C=C\c1ccccc1)/C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K12 compound treatment 9.4174884E7 -8450000.0 -0.48 9.4913754E7 -6960000.0 -0.43 -0.6448 -0.9983 3186 SPBio_002130 CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K13 compound treatment 8.6318849E7 -1.63E7 -0.93 8.8937699E7 -1.29E7 -0.8 -1.2228 -0.997 3198547 SPBio_002131 CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)c4ccccc4C(=O)O)c5nc6ccccc6n5C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K14 compound treatment 9.4018002E7 -8600000.0 -0.49 9.344565E7 -8430000.0 -0.52 -0.7152 -0.9996 920 SPBio_002132 CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K15 compound treatment 3.8414247E7 -6.42E7 -3.67 3.7216908E7 -6.47E7 -3.99 -5.4131 -0.9991 2060467 SPBio_002133 COc1ccc2C(=O)/C(=C\c3ccc(OC)c(OC)c3)/COc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K16 compound treatment 9.8622641E7 -4000000.0 -0.23 1.03353063E8 1480000.0 0.09 -0.0973 -0.3953 3127 SPBio_002134 CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K17 compound treatment 9.4855146E7 -7770000.0 -0.44 9.9352708E7 -2520000.0 -0.16 -0.4239 -0.9012 1024489 SPBio_002135 Cc1cc(O)cc(=O)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K18 compound treatment 9.0682454E7 -1.19E7 -0.68 9.5480275E7 -6400000.0 -0.39 -0.7613 -0.966 1318 SPBio_002136 CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K19 compound treatment 9.0650442E7 -1.2E7 -0.68 8.9943451E7 -1.19E7 -0.74 -1.0039 -0.9993 3045136 SPBio_002137 CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)C(CCC3C[C@@H](O)CC(=O)O3)[C@@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K20 compound treatment 9.689746E7 -5720000.0 -0.33 9.755658E7 -4320000.0 -0.27 -0.4196 -0.9948 884 SPBio_002138 CN(C)CCC(c1ccccc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K21 compound treatment 9.3043245E7 -9580000.0 -0.55 7.7953174E7 -2.39E7 -1.47 -1.4299 -0.909 794 SPBio_002139 Nc1cc(c[nH]c1=O)c2ccncc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K22 compound treatment 9.4897324E7 -7720000.0 -0.44 9.3108898E7 -8770000.0 -0.54 -0.6943 -0.995 965 SPBio_002140 C(C1=NCCN1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K23 mock treatment 9.5869312E7 -6750000.0 -0.39 9.3075851E7 -8800000.0 -0.54 -0.6565 -0.9861 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 K24 mock treatment 1.01744272E8 -877000.0 -0.05 1.00606529E8 -1270000.0 -0.08 -0.0908 -0.9768 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L01 mock treatment 1.0014216E8 -2480000.0 -0.14 9.9922432E7 -1950000.0 -0.12 -0.1854 -0.9967 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L02 mock treatment 9.1817489E7 -1.08E7 -0.62 9.0078779E7 -1.18E7 -0.73 -0.9509 -0.9967 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L03 compound treatment 1.04686308E8 2060000.0 0.12 1.03703349E8 1830000.0 0.11 0.1631 0.9997 72 SPBio_002141 Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L04 compound treatment 9.4509475E7 -8110000.0 -0.46 9.7578403E7 -4300000.0 -0.26 -0.5152 -0.9648 347 SPBio_002142 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L05 compound treatment 9.8700355E7 -3920000.0 -0.22 9.89287E7 -2950000.0 -0.18 -0.287 -0.9946 4362 SPBio_002143 CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L06 compound treatment 9.7283355E7 -5340000.0 -0.31 9.6812276E7 -5060000.0 -0.31 -0.4365 -0.9999 3069079 SPBio_002144 CN1CCCN=C1/C=C/c2cccs2.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L07 compound treatment 9.2616106E7 -1.0E7 -0.57 9.5258637E7 -6620000.0 -0.41 -0.6928 -0.9863 3487390 SPBio_002145 OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L08 compound treatment 9.5782913E7 -6840000.0 -0.39 9.6596415E7 -5280000.0 -0.33 -0.5065 -0.9959 1144 SPBio_002146 O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L09 compound treatment 9.4492546E7 -8130000.0 -0.46 9.266392E7 -9210000.0 -0.57 -0.7301 -0.995 355 SPBio_002147 COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L10 compound treatment 9.6539071E7 -6080000.0 -0.35 9.5273242E7 -6600000.0 -0.41 -0.5336 -0.9969 796 SPBio_002148 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L11 compound treatment 4.3243831E7 -5.94E7 -3.39 3.7927278E7 -6.39E7 -3.94 -5.187 -0.9972 464 SPBio_002149 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L12 compound treatment 9.212653E7 -1.05E7 -0.6 9.3981143E7 -7900000.0 -0.49 -0.7683 -0.9946 1346 SPBio_002150 CCN(CC)CCNC(=O)COc1ccc(OC)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L13 compound treatment 3.5674626E7 -6.69E7 -3.83 3.9611746E7 -6.23E7 -3.84 -5.4195 -1.0 709 SPBio_002151 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L14 compound treatment 9.3594672E7 -9030000.0 -0.52 9.1033592E7 -1.08E7 -0.67 -0.8374 -0.9918 1339 SPBio_002152 CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L15 compound treatment 9.2843928E7 -9780000.0 -0.56 9.4911193E7 -6970000.0 -0.43 -0.6987 -0.9915 3189055 SPBio_002153 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L16 compound treatment 4.0083045E7 -6.25E7 -3.57 4.0122083E7 -6.18E7 -3.81 -5.2191 -0.9995 1350 SPBio_002154 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L17 compound treatment 4.3227483E7 -5.94E7 -3.39 5.1965595E7 -4.99E7 -3.08 -4.5758 -0.9988 1590 SPBio_002155 CC(C)(C)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L18 compound treatment 9.6061121E7 -6560000.0 -0.37 9.631153E7 -5570000.0 -0.34 -0.5077 -0.999 699 SPBio_002156 OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L19 compound treatment 9.7148935E7 -5470000.0 -0.31 9.7967979E7 -3910000.0 -0.24 -0.3915 -0.9917 3060388 SPBio_002157 CO/N=C(\C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C)/c3csc(N)n3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L20 compound treatment 1.00549701E8 -2070000.0 -0.12 1.00352036E8 -1520000.0 -0.09 -0.1502 -0.9935 1209 SPBio_002158 CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L21 compound treatment 9.4082778E7 -8540000.0 -0.49 1.00147852E8 -1730000.0 -0.11 -0.4204 -0.8417 1418 SPBio_002159 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L22 compound treatment 9.1535772E7 -1.11E7 -0.63 9.0298905E7 -1.16E7 -0.71 -0.9527 -0.9982 3069113 SPBio_002160 CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L23 mock treatment 9.6523269E7 -6100000.0 -0.35 9.464744E7 -7230000.0 -0.45 -0.5616 -0.9926 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 L24 mock treatment 1.05885299E8 3260000.0 0.19 1.09689987E8 7810000.0 0.48 0.4725 0.9148 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M01 mock treatment 1.13227645E8 1.06E7 0.61 1.12850292E8 1.1E7 0.68 0.9069 0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M02 mock treatment 1.0443276E8 1810000.0 0.1 1.07562407E8 5690000.0 0.35 0.321 0.8784 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M03 compound treatment 9.7786888E7 -4830000.0 -0.28 9.5284989E7 -6590000.0 -0.41 -0.4827 -0.9823 1110410 SPBio_002161 COc1ccc(C(=O)C)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M04 compound treatment 9.776226E7 -4860000.0 -0.28 9.7083813E7 -4790000.0 -0.3 -0.4053 -0.9995 3188938 SPBio_002162 CN1CCCN=C1/C=C/c2sccc2C.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M05 compound treatment 8.8774014E7 -1.38E7 -0.79 9.4081464E7 -7800000.0 -0.48 -0.8994 -0.9714 1582 SPBio_002163 O=C1CCO1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M06 compound treatment 9.253441E7 -1.01E7 -0.58 9.2587767E7 -9290000.0 -0.57 -0.8125 -1.0 3068999 SPBio_002164 CN1[C@H]2CC[C@@H]1CC(C2)OC(=O)C(O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M07 compound treatment 7.4003541E7 -2.86E7 -1.64 7.7941214E7 -2.39E7 -1.48 -2.1998 -0.9987 104 SPBio_002165 C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M08 compound treatment 5.9240992E7 -4.34E7 -2.48 5.7135298E7 -4.47E7 -2.76 -3.7033 -0.9986 110 SPBio_002166 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M09 compound treatment 9.2447712E7 -1.02E7 -0.58 9.1776043E7 -1.01E7 -0.62 -0.8514 -0.9994 1000323 SPBio_002167 N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M10 compound treatment 7.5018629E7 -2.76E7 -1.58 7.7071811E7 -2.48E7 -1.53 -2.1967 -0.9999 436 SPBio_002168 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M11 compound treatment 8.4799266E7 -1.78E7 -1.02 8.7045805E7 -1.48E7 -0.91 -1.3667 -0.9985 1328 SPBio_002169 OC(CCN1CCCCC1)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M12 compound treatment 9.4483011E7 -8140000.0 -0.47 9.6146495E7 -5730000.0 -0.35 -0.5787 -0.9908 1002 SPBio_002170 CN(C)CCOC(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M13 compound treatment 8.8269364E7 -1.44E7 -0.82 9.3341164E7 -8540000.0 -0.53 -0.952 -0.977 1510 SPBio_002171 CN(C)CCN(Cc1cccs1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M14 compound treatment 8.9334236E7 -1.33E7 -0.76 9.2475879E7 -9400000.0 -0.58 -0.9467 -0.9911 728 SPBio_002172 Cc1cc(nnc1NCCN2CCOCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M15 compound treatment 8.4732156E7 -1.79E7 -1.02 8.4421411E7 -1.75E7 -1.08 -1.4838 -0.9997 1318 SPBio_002173 CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M16 compound treatment 6.6757221E7 -3.59E7 -2.05 7.1434391E7 -3.04E7 -1.88 -2.7763 -0.999 814 SPBio_002174 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M17 compound treatment 9.314267E7 -9480000.0 -0.54 9.4860373E7 -7020000.0 -0.43 -0.6889 -0.9938 3174608 SPBio_002175 COC1C(O)C(O)C(O)[C@@H](O)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M18 compound treatment 9.003207E7 -1.26E7 -0.72 9.2931123E7 -8950000.0 -0.55 -0.8987 -0.9914 3471598 SPBio_002176 CC(COc1ccccc1)NC(C)C(O)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M19 compound treatment 9.8222779E7 -4400000.0 -0.25 9.500323E7 -6870000.0 -0.42 -0.4774 -0.9689 1035250 SPBio_002177 CC(=O)c1c(O)cc(O)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M20 compound treatment 9.0943178E7 -1.17E7 -0.67 9.1606078E7 -1.03E7 -0.63 -0.9196 -0.9997 1223 SPBio_002178 CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M21 compound treatment 9.3837084E7 -8780000.0 -0.5 9.1790664E7 -1.01E7 -0.62 -0.7946 -0.9944 3080396 SPBio_002179 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M22 compound treatment 9.4828369E7 -7790000.0 -0.45 9.3102912E7 -8770000.0 -0.54 -0.6974 -0.9953 971 SPBio_002180 CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M23 mock treatment 9.4716915E7 -7900000.0 -0.45 9.2033294E7 -9840000.0 -0.61 -0.7485 -0.9894 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 M24 mock treatment 1.06463255E8 3840000.0 0.22 1.08791627E8 6910000.0 0.43 0.4567 0.9524 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N01 mock treatment 1.06794559E8 4170000.0 0.24 1.09035231E8 7160000.0 0.44 0.4807 0.9583 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N02 mock treatment 1.05390118E8 2770000.0 0.16 1.06134597E8 4260000.0 0.26 0.2975 0.9707 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N03 compound treatment 8.9552275E7 -1.31E7 -0.75 9.1851736E7 -1.0E7 -0.62 -0.9651 -0.9956 1000056 SPBio_002181 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N04 compound treatment 1.00578021E8 -2040000.0 -0.12 1.02610714E8 734000.0 0.05 -0.0506 -0.4039 747 SPBio_002182 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N05 compound treatment 9.6372804E7 -6250000.0 -0.36 9.6408282E7 -5470000.0 -0.34 -0.4909 -0.9996 1301 SPBio_002183 OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N06 compound treatment 8.4862858E7 -1.78E7 -1.01 8.5500981E7 -1.64E7 -1.01 -1.4315 -1.0 3189176 SPBio_002184 CCCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)C(NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N07 compound treatment 4.8042631E7 -5.46E7 -3.12 6.4229408E7 -3.76E7 -2.32 -3.8466 -0.9894 1360 SPBio_002185 Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N08 compound treatment 8.8796549E7 -1.38E7 -0.79 9.1007458E7 -1.09E7 -0.67 -1.0325 -0.9966 816 SPBio_002186 Cc1cc(cc(C)c1CC2=NCCN2)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N09 compound treatment 7.908981E7 -2.35E7 -1.34 8.0316751E7 -2.16E7 -1.33 -1.8907 -1.0 80 SPBio_002187 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N10 compound treatment 8.4647796E7 -1.8E7 -1.03 8.2949823E7 -1.89E7 -1.17 -1.5513 -0.998 1181 SPBio_002188 Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N11 compound treatment 8.4725097E7 -1.79E7 -1.02 8.2232881E7 -1.96E7 -1.21 -1.5795 -0.9965 901 SPBio_002189 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N12 compound treatment 9.1515422E7 -1.11E7 -0.63 9.2302187E7 -9570000.0 -0.59 -0.8662 -0.9993 1162 SPBio_002190 Cc1c(NC(=O)c2cccnc2)c(=O)n(c3ccccc3)n1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N13 compound treatment 6.5562425E7 -3.71E7 -2.12 7.4011443E7 -2.79E7 -1.72 -2.7122 -0.9946 368 SPBio_002191 CC/C(=C(\c1ccccc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N14 compound treatment 7.9136429E7 -2.35E7 -1.34 7.8018091E7 -2.39E7 -1.47 -1.989 -0.999 3069117 SPBio_002192 COC1CC(=O)C[C@@H](C)[C@@]21Oc3c(C2=O)c(OC)cc(OC)c3Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N15 compound treatment 8.4309832E7 -1.83E7 -1.05 8.9104196E7 -1.28E7 -0.79 -1.2967 -0.9902 783 SPBio_002193 CO[C@@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]2Cc4cn(C)c5cccc1c45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N16 compound treatment 9.9075658E7 -3550000.0 -0.2 1.01183191E8 -694000.0 -0.04 -0.1735 -0.8378 386963 SPBio_002194 Clc1ccc(Cn2c(CN3CCCC3)nc4ccccc24)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N17 compound treatment 9.5350196E7 -7270000.0 -0.42 9.6046819E7 -5830000.0 -0.36 -0.548 -0.9974 2784 SPBio_002195 C[C@@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@]1(O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N18 compound treatment 8.8894552E7 -1.37E7 -0.78 9.0054317E7 -1.18E7 -0.73 -1.07 -0.9993 1075 SPBio_002196 CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N19 compound treatment 7.9560967E7 -2.31E7 -1.32 8.1183628E7 -2.07E7 -1.28 -1.8339 -0.9999 3189056 SPBio_002197 CN(C)S(=O)(=O)c1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N20 compound treatment 1.00186391E8 -2440000.0 -0.14 9.8665147E7 -3210000.0 -0.2 -0.2384 -0.9851 1016 SPBio_002198 CN1CCOC(c2ccccc2)c3ccccc3C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N21 compound treatment 8.4393593E7 -1.82E7 -1.04 9.3067184E7 -8810000.0 -0.54 -1.1206 -0.9539 3189057 SPBio_002199 CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)C(=O)N[C@]5(C)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C5=O.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N22 compound treatment 9.5991815E7 -6630000.0 -0.38 9.2223997E7 -9650000.0 -0.6 -0.6887 -0.9763 3046406 SPBio_002200 Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N23 mock treatment 9.1709065E7 -1.09E7 -0.62 9.3774657E7 -8100000.0 -0.5 -0.7941 -0.9939 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 N24 mock treatment 1.01730089E8 -891000.0 -0.05 1.04441721E8 2560000.0 0.16 0.0758 0.4562 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O01 mock treatment 1.07846554E8 5230000.0 0.3 1.08503315E8 6630000.0 0.41 0.5 0.9881 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O02 mock treatment 9.4871404E7 -7750000.0 -0.44 9.7751516E7 -4130000.0 -0.25 -0.493 -0.9653 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O03 compound treatment 8.9672005E7 -1.29E7 -0.74 9.1249506E7 -1.06E7 -0.66 -0.9865 -0.9981 1572 SPBio_002201 CCCC(C)C1(CC)C(=O)NC(=NC1=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O04 compound treatment 9.6354917E7 -6270000.0 -0.36 9.5196823E7 -6680000.0 -0.41 -0.5444 -0.9976 1125 SPBio_002202 CCOC(=O)NNc1nncc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O05 compound treatment 9.1408969E7 -1.12E7 -0.64 9.0929337E7 -1.09E7 -0.67 -0.9303 -0.9997 2060373 SPBio_002203 COc1c(O)cc2c(cc(=O)oc2c1OC)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O06 compound treatment 9.4592342E7 -8030000.0 -0.46 9.585426E7 -6020000.0 -0.37 -0.587 -0.9945 1174 SPBio_002204 CN(C)CCCN1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O07 compound treatment 8.9006861E7 -1.36E7 -0.78 8.9840993E7 -1.2E7 -0.74 -1.0748 -0.9997 1019888 SPBio_002205 NCC(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O08 compound treatment 9.5631905E7 -6990000.0 -0.4 9.0631134E7 -1.12E7 -0.69 -0.7726 -0.9657 3188939 SPBio_002206 CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O09 compound treatment 9.1693914E7 -1.09E7 -0.62 9.0755148E7 -1.11E7 -0.69 -0.9264 -0.9989 2069272 SPBio_002207 CC1C[C@H]2CC(=O)[C@H]3CCCN4CCC[C@H]2[C@]34C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O10 compound treatment 9.0371731E7 -1.22E7 -0.7 8.4876028E7 -1.7E7 -1.05 -1.2361 -0.9808 1365 SPBio_002208 CN(C)CCC=C1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O11 compound treatment 9.4176263E7 -8450000.0 -0.48 9.1448872E7 -1.04E7 -0.64 -0.7958 -0.99 2060313 SPBio_002209 C/C/1=C/CC(C)(C)\C=C\C\C(=C\CC1)\C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O12 compound treatment 1.01697434E8 -924000.0 -0.05 1.0009603E8 -1780000.0 -0.11 -0.115 -0.9438 872 SPBio_002210 CCN(CC)CCOC(=O)C(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O13 compound treatment 9.2392646E7 -1.02E7 -0.58 9.5267559E7 -6610000.0 -0.41 -0.7014 -0.9844 2060368 SPBio_002211 CNC(Cc1c[nH]c2ccccc12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O14 compound treatment 9.6383836E7 -6240000.0 -0.36 9.7382852E7 -4490000.0 -0.28 -0.448 -0.9922 969 SPBio_002212 CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O15 compound treatment 9.5109143E7 -7510000.0 -0.43 9.6081727E7 -5800000.0 -0.36 -0.5562 -0.9958 1635952 SPBio_002213 Cn1nnnc1SCC2=C(N3C(SC2)C(NC(=O)C(O)c4ccccc4)C3=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O16 compound treatment 9.5567631E7 -7050000.0 -0.4 9.4687403E7 -7190000.0 -0.44 -0.5984 -0.9989 2080073 SPBio_002214 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O17 compound treatment 9.4947501E7 -7670000.0 -0.44 9.7990515E7 -3890000.0 -0.24 -0.4795 -0.9595 1573 SPBio_002215 CCCC(C)C1(CC)C(=O)NC(=NC1=O)S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O18 compound treatment 5.7989611E7 -4.46E7 -2.55 4.9217619E7 -5.27E7 -3.25 -4.099 -0.9929 731 SPBio_002216 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O19 compound treatment 9.4726617E7 -7890000.0 -0.45 9.060086E7 -1.13E7 -0.7 -0.8105 -0.9781 89599 SPBio_002217 OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O20 compound treatment 8.581967E7 -1.68E7 -0.96 8.9937104E7 -1.19E7 -0.74 -1.1994 -0.9914 1001312 SPBio_002218 C[N+]1(C)CCC(=C(c2ccccc2)c3ccccc3)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O21 compound treatment 1.03526047E8 905000.0 0.05 1.01555619E8 -321000.0 -0.02 0.0226 0.4075 3198548 SPBio_002219 OC(=O)CCC/C=C\C[C@@H]1CO[C@@H](O[C@@H]1c2ccccc2O)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O22 compound treatment 9.160937E7 -1.1E7 -0.63 9.4109223E7 -7770000.0 -0.48 -0.7836 -0.9909 1053 SPBio_002220 COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O23 mock treatment 9.9000956E7 -3620000.0 -0.21 9.8076943E7 -3800000.0 -0.23 -0.3119 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 O24 mock treatment 1.11868716E8 9250000.0 0.53 1.13511454E8 1.16E7 0.72 0.8808 0.9887 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P01 mock treatment 1.27381999E8 2.48E7 1.42 1.14829481E8 1.3E7 0.8 1.5652 0.9633 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P02 mock treatment 1.06833748E8 4210000.0 0.24 1.12951807E8 1.11E7 0.68 0.653 0.902 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P03 compound treatment 1.11257478E8 8640000.0 0.49 1.07230236E8 5350000.0 0.33 0.5823 0.9808 3069044 SPBio_002221 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P04 compound treatment 9.6572292E7 -6050000.0 -0.35 1.0331152E8 1430000.0 0.09 -0.1819 -0.5098 805 SPBio_002222 CCc1cccc2c3CCOC(CC)(CC(=O)O)c3[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P05 compound treatment 9.3999735E7 -8620000.0 -0.49 9.7244387E7 -4630000.0 -0.29 -0.5503 -0.9663 3189058 SPBio_002223 COC1CC(O[C@H]2[C@H](C)[C@@H](OC3OC(C)CC(C3O)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)OC(C)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P06 compound treatment 1.01084083E8 -1540000.0 -0.09 9.4086438E7 -7790000.0 -0.48 -0.4017 -0.8228 3069144 SPBio_002224 C[N+]1([O-])[C@H]2C[C@@H](C[C@@H]1[C@H]3O[C@H]32)OC(=O)[C@H](CO)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P07 compound treatment 1.0414098E8 1520000.0 0.09 9.5658549E7 -6220000.0 -0.38 -0.2096 -0.5334 3189059 SPBio_002225 CCC(=O)OC1C(C)OC(CC1(C)O)OC2C(C)OC(O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)C(O)C2N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P08 compound treatment 8.6978293E7 -1.56E7 -0.89 9.0741988E7 -1.11E7 -0.69 -1.1175 -0.9915 1000200 SPBio_002226 CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)[C@@H](CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P09 compound treatment 9.457558E7 -8050000.0 -0.46 9.3950538E7 -7930000.0 -0.49 -0.6706 -0.9995 3069045 SPBio_002227 CO[C@H]1[C@@H](CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(C2O)N(C)C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P10 compound treatment 8.6219619E7 -1.64E7 -0.94 8.5140103E7 -1.67E7 -1.03 -1.3924 -0.9989 3487401 SPBio_002228 NC(=O)OCC(O)COc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P11 compound treatment 5.5126942E7 -4.75E7 -2.71 5.6537754E7 -4.53E7 -2.79 -3.8956 -0.9999 3189060 SPBio_002229 CC(=O)O[C@@H]1C2=C(C)[C@@H](C[C@](O)([C@H](OC(=O)c3ccccc3)[C@H]4[C@]5(CO[C@H]5C[C@@H](O)[C@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@@H](O)[C@H](NC(=O)c6ccccc6)c7ccccc7 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P12 compound treatment 8.1085576E7 -2.15E7 -1.23 7.2096865E7 -2.98E7 -1.84 -2.1684 -0.9811 3189177 SPBio_002230 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N=C)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P13 compound treatment 9.0313237E7 -1.23E7 -0.7 9.9192608E7 -2680000.0 -0.17 -0.6144 -0.8502 3189061 SPBio_002231 CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C/C=C(\C)/C(O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P14 compound treatment 8.6253758E7 -1.64E7 -0.94 9.01276E7 -1.17E7 -0.72 -1.1736 -0.992 2997 SPBio_002232 COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P15 compound treatment 8.9805663E7 -1.28E7 -0.73 9.4276357E7 -7600000.0 -0.47 -0.8492 -0.9767 1257 SPBio_002233 CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P16 compound treatment 9.1309818E7 -1.13E7 -0.65 9.8916374E7 -2960000.0 -0.18 -0.5862 -0.8726 1323 SPBio_002234 CC1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P17 compound treatment 1.02780788E8 159000.0 0.01 1.08297014E8 6420000.0 0.4 0.2863 0.7232 3069046 SPBio_002235 NCC1OC(COC[C@@H]2C(O)[C@H](OC3C(O)C(N)CC(N)C3OC4OC(CN)C(O)C(O)C4N)O[C@@H]2CO)C(N)C(O)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P18 compound treatment 9.0912378E7 -1.17E7 -0.67 9.0841132E7 -1.1E7 -0.68 -0.9542 -1.0 999 SPBio_002236 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P19 compound treatment 9.2437982E7 -1.02E7 -0.58 9.1762441E7 -1.01E7 -0.62 -0.8524 -0.9994 3069047 SPBio_002237 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P20 compound treatment 9.4466716E7 -8150000.0 -0.47 9.8683691E7 -3190000.0 -0.2 -0.4687 -0.9265 1443 SPBio_002238 CN(C)CCOC(c1ccccc1)c2ccccc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P21 compound treatment 9.4143858E7 -8480000.0 -0.48 9.79911E7 -3890000.0 -0.24 -0.512 -0.9472 3189062 SPBio_002239 CN[C@H](C)[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@@H](CC[C@H]3N)[C@@H](C)N)[C@@H]2O)OC[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P22 compound treatment 9.8464515E7 -4160000.0 -0.24 1.06341664E8 4460000.0 0.28 0.0266 0.0732 1291 SPBio_002240 CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P23 mock treatment 1.05554651E8 2930000.0 0.17 1.14278098E8 1.24E7 0.76 0.6591 0.8422 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2164 P24 mock treatment 1.13853203E8 1.12E7 0.64 1.1487947E8 1.3E7 0.8 1.0207 0.9939 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A01 mock treatment 1.22035458E8 1.48E7 0.84 1.25748284E8 1.65E7 1.01 1.3143 0.9958 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A02 mock treatment 1.07883085E8 616000.0 0.04 1.14363977E8 5080000.0 0.31 0.2462 0.7817 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A03 compound treatment 1.07668087E8 401000.0 0.02 1.15902482E8 6620000.0 0.41 0.3045 0.7457 1425 SPBio_002241 CC(N)COc1c(C)cccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A04 compound treatment 1.18218399E8 1.1E7 0.63 1.20746439E8 1.15E7 0.71 0.942 0.9982 3189183 SPBio_002242 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A05 compound treatment 1.03649032E8 -3620000.0 -0.21 1.06522593E8 -2760000.0 -0.17 -0.2667 -0.9954 3101 SPBio_002243 Cc1c(oc2c(cccc2c1=O)C(=O)OCCN3CCCCC3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A06 compound treatment 1.06159759E8 -1110000.0 -0.06 1.01531939E8 -7760000.0 -0.48 -0.3828 -0.7938 3480229 SPBio_002244 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A07 compound treatment 8.128414E7 -2.6E7 -1.48 9.1560519E7 -1.77E7 -1.09 -1.8227 -0.9886 769 SPBio_002245 CCCCOc1ccc(CC(=O)NO)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A08 compound treatment 1.03979615E8 -3290000.0 -0.19 1.04137211E8 -5150000.0 -0.32 -0.3573 -0.9687 1132 SPBio_002246 CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A09 compound treatment 8.6589017E7 -2.07E7 -1.18 1.00320427E8 -8970000.0 -0.55 -1.2265 -0.9401 1469 SPBio_002247 CCC1(CCC(=O)NC1=O)c2ccc(N)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A10 compound treatment 9.8376158E7 -8890000.0 -0.51 1.07053293E8 -2230000.0 -0.14 -0.4567 -0.8675 3068879 SPBio_002248 C[C@@H](N)[C@H](O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A11 compound treatment 9.1603945E7 -1.57E7 -0.9 9.7870809E7 -1.14E7 -0.7 -1.1306 -0.9929 858 SPBio_002249 OCC(O)CN1CCN(CC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A12 compound treatment 8.6763501E7 -2.05E7 -1.17 9.3565233E7 -1.57E7 -0.97 -1.5139 -0.9956 3068880 SPBio_002250 OCC(O)[C@H]1OC(=O)C(O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A13 compound treatment 8.7533442E7 -1.97E7 -1.13 9.6490074E7 -1.28E7 -0.79 -1.3553 -0.9847 3173239 SPBio_002251 CC(N/C(=N/C#N)/Nc1ccncc1)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A14 compound treatment 9.2235968E7 -1.5E7 -0.86 9.2614511E7 -1.67E7 -1.03 -1.3342 -0.996 800 SPBio_002252 C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A15 compound treatment 5.1286366E7 -5.6E7 -3.2 5.368007E7 -5.56E7 -3.43 -4.6861 -0.9994 1185085 SPBio_002253 CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A16 compound treatment 9.2073509E7 -1.52E7 -0.87 9.6808306E7 -1.25E7 -0.77 -1.1579 -0.9982 3063 SPBio_002254 CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4C)c5ccc(O)cc5)C(=O)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A17 compound treatment 9.3063909E7 -1.42E7 -0.81 1.01586938E8 -7700000.0 -0.47 -0.9096 -0.9673 448 SPBio_002255 Clc1cccc(Cl)c1N=C2NCCN2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A18 compound treatment 9.6226076E7 -1.1E7 -0.63 1.06455789E8 -2830000.0 -0.17 -0.5696 -0.87 3173242 SPBio_002256 Nc1nc2cc(Cl)ccc2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A19 compound treatment 9.6830021E7 -1.04E7 -0.6 1.01382544E8 -7900000.0 -0.49 -0.7663 -0.995 1101055 SPBio_002257 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A20 compound treatment 9.595193E7 -1.13E7 -0.65 1.01807693E8 -7480000.0 -0.46 -0.7833 -0.9863 1516 SPBio_002258 Nc1c2CCCCc2nc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A21 compound treatment 1.05518741E8 -1750000.0 -0.1 1.0880695E8 -480000.0 -0.03 -0.0916 -0.8789 690 SPBio_002259 CC(C)NCC(O)COc1ccccc1CC=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A22 compound treatment 1.07076599E8 -190000.0 -0.01 1.0486466E8 -4420000.0 -0.27 -0.2005 -0.7347 3487402 SPBio_002260 CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A23 mock treatment 1.09475591E8 2210000.0 0.13 1.15523377E8 6240000.0 0.38 0.3611 0.8924 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 A24 mock treatment 1.23534361E8 1.63E7 0.93 1.23281711E8 1.4E7 0.86 1.2674 0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B01 mock treatment 1.21071781E8 1.38E7 0.79 1.2677051E8 1.75E7 1.08 1.3199 0.9882 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B02 mock treatment 9.8213403E7 -9050000.0 -0.52 1.03630113E8 -5660000.0 -0.35 -0.6125 -0.9816 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B03 compound treatment 9.2461631E7 -1.48E7 -0.85 9.7738011E7 -1.15E7 -0.71 -1.1017 -0.9963 2717 SPBio_002261 CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B04 compound treatment 8.9581877E7 -1.77E7 -1.01 9.4244504E7 -1.5E7 -0.93 -1.3704 -0.9991 429 SPBio_002262 NCCc1c[nH]c2ccc(O)cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B05 compound treatment 9.209413E7 -1.52E7 -0.87 1.00270414E8 -9020000.0 -0.56 -1.0062 -0.9769 1403 SPBio_002263 COC(=O)C1=CCCN(C)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B06 compound treatment 9.358521E7 -1.37E7 -0.78 9.7931772E7 -1.14E7 -0.7 -1.0479 -0.9985 1000242 SPBio_002264 CN(C)CCn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4csc(N)n4)C3=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B07 compound treatment 9.5827319E7 -1.14E7 -0.65 9.4668101E7 -1.46E7 -0.9 -1.0995 -0.9876 1000219 SPBio_002265 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B08 compound treatment 8.1153127E7 -2.61E7 -1.49 9.1866326E7 -1.74E7 -1.07 -1.8147 -0.987 3189438 SPBio_002266 Cc1n[nH]c(=O)[nH]c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B09 compound treatment 7.8672392E7 -2.86E7 -1.63 8.7431273E7 -2.19E7 -1.35 -2.1082 -0.9954 1001661 SPBio_002267 CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B10 compound treatment 8.2823074E7 -2.44E7 -1.4 9.5639653E7 -1.36E7 -0.84 -1.5827 -0.9705 1077918 SPBio_002268 Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B11 compound treatment 7.2051121E7 -3.52E7 -2.01 8.4545481E7 -2.47E7 -1.53 -2.5016 -0.9906 3189307 SPBio_002269 CC(C)CC(NC(=O)[C@H](C)NC(=O)C[C@H](O)C(CC(C)C)NC(=O)[C@@H](NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B12 compound treatment 8.3470319E7 -2.38E7 -1.36 8.9588534E7 -1.97E7 -1.21 -1.8203 -0.9984 3173761 SPBio_002270 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B13 compound treatment 7.6432957E7 -3.08E7 -1.76 8.7940043E7 -2.13E7 -1.32 -2.1766 -0.9897 3068973 SPBio_002271 C(CN1CCOCC1)Nc2cc3CCCc4ccccc4-c3nn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B14 compound treatment 7.9244471E7 -2.8E7 -1.6 8.7769291E7 -2.15E7 -1.33 -2.0704 -0.9956 3189439 SPBio_002272 CC(C)CCCCC(=O)N[C@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CCN)C(=O)N[C@@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CNC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)C)[C@@H](C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B15 compound treatment 9.4569831E7 -1.27E7 -0.73 9.5616807E7 -1.37E7 -0.84 -1.109 -0.9972 1408 SPBio_002273 NC1(CC2CC3CC(C2)C1)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B16 compound treatment 2.9323881E7 -7.79E7 -4.45 3.0622268E7 -7.87E7 -4.85 -6.5787 -0.9991 2117312 SPBio_002274 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B17 compound treatment 8.572319E7 -2.15E7 -1.23 9.5971432E7 -1.33E7 -0.82 -1.451 -0.9806 3068976 SPBio_002275 Clc1ccc(CCC(Cn2ccnc2)Sc3c(Cl)cccc3Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B18 compound treatment 8.1676395E7 -2.56E7 -1.46 8.7067421E7 -2.22E7 -1.37 -2.0027 -0.9995 2911 SPBio_002276 CN(C)CC/C=C\1/c2ccccc2CSc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B19 compound treatment 8.7765436E7 -1.95E7 -1.11 9.1104718E7 -1.82E7 -1.12 -1.5806 -1.0 26 SPBio_002277 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B20 compound treatment 1.0630287E8 -964000.0 -0.06 1.01494607E8 -7790000.0 -0.48 -0.3786 -0.7831 3189440 SPBio_002278 CC(C)(O/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C[n+]3ccccc3)\c4csc(N)n4)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B21 compound treatment 8.9260969E7 -1.8E7 -1.03 9.4909401E7 -1.44E7 -0.89 -1.3544 -0.9972 2081486 SPBio_002279 CC1OC(O[C@@H]/2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(=O)O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C2)C(O)C(N)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B22 compound treatment 9.2288553E7 -1.5E7 -0.86 9.5807583E7 -1.35E7 -0.83 -1.1929 -0.9999 3060173 SPBio_002280 NC(=N)NCc1cccc(I)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B23 mock treatment 9.0625038E7 -1.66E7 -0.95 9.5949234E7 -1.33E7 -0.82 -1.2539 -0.9974 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 B24 mock treatment 1.12882086E8 5620000.0 0.32 1.14216405E8 4930000.0 0.3 0.4418 0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C01 mock treatment 1.05196672E8 -2070000.0 -0.12 1.08592538E8 -695000.0 -0.04 -0.114 -0.9056 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C02 mock treatment 9.3915476E7 -1.34E7 -0.76 1.01142383E8 -8150000.0 -0.5 -0.8946 -0.9794 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C03 compound treatment 9.0037657E7 -1.72E7 -0.98 1.0198722E8 -7300000.0 -0.45 -1.0145 -0.937 1282 SPBio_002281 NS(=O)(=O)c1cc2c(N=CNS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C04 compound treatment 8.7277615E7 -2.0E7 -1.14 9.6997074E7 -1.23E7 -0.76 -1.3435 -0.9801 907527 SPBio_002282 C(C#CCN1CCCC1)N2CCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C05 compound treatment 9.7179693E7 -1.01E7 -0.58 9.7880353E7 -1.14E7 -0.7 -0.9049 -0.9951 3036 SPBio_002283 OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C06 compound treatment 8.8225371E7 -1.9E7 -1.09 9.7553053E7 -1.17E7 -0.72 -1.281 -0.9803 1486 SPBio_002284 CC(C)NCC(O)COc1ccc(NC(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C07 compound treatment 9.828814E7 -8980000.0 -0.51 9.866136E7 -1.06E7 -0.66 -0.826 -0.9927 1000286 SPBio_002285 C[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C08 compound treatment 7.8473976E7 -2.88E7 -1.65 8.9786317E7 -1.95E7 -1.2 -2.0136 -0.9881 3189185 SPBio_002286 Cc1cn([C@H]2C[C@@H](N=[N+]=N)[C@@H](CO)O2)c(=O)[nH]c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C09 compound treatment 6.6156085E7 -4.11E7 -2.35 8.3060613E7 -2.62E7 -1.62 -2.8046 -0.9834 809 SPBio_002287 CNCCC=C1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C10 compound treatment 8.1647197E7 -2.56E7 -1.46 9.2808411E7 -1.65E7 -1.02 -1.7536 -0.984 1192 SPBio_002288 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C11 compound treatment 9.5561225E7 -1.17E7 -0.67 9.9478395E7 -9810000.0 -0.6 -0.9006 -0.9987 112 SPBio_002289 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C12 compound treatment 8.7114522E7 -2.02E7 -1.15 9.1960429E7 -1.73E7 -1.07 -1.5697 -0.9993 3068881 SPBio_002290 CCCOc1ccccc1c2nc(=O)c3[nH]nnc3[nH]2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C13 compound treatment 5.9815212E7 -4.75E7 -2.71 6.9129166E7 -4.02E7 -2.48 -3.668 -0.999 1000009 SPBio_002291 C/C(=C\C=C\C(=C/C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C14 compound treatment 9.2987555E7 -1.43E7 -0.82 9.4695649E7 -1.46E7 -0.9 -1.2131 -0.9988 1471 SPBio_002292 CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C15 compound treatment 5.4904555E7 -5.24E7 -2.99 6.6769669E7 -4.25E7 -2.62 -3.9693 -0.9978 104 SPBio_002293 C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C16 compound treatment 8.1201816E7 -2.61E7 -1.49 8.8331808E7 -2.1E7 -1.29 -1.9668 -0.9975 2431 SPBio_002294 CCN(CC)CCNC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C17 compound treatment 8.152033E7 -2.57E7 -1.47 9.0298415E7 -1.9E7 -1.17 -1.8682 -0.9936 746 SPBio_002295 C(N(Cc1ccccc1)c2ccccc2)C3=NCCN3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C18 compound treatment 8.5271925E7 -2.2E7 -1.26 9.0590789E7 -1.87E7 -1.15 -1.7038 -0.9991 3189186 SPBio_002296 CNc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C19 compound treatment 7.3577438E7 -3.37E7 -1.93 7.6501929E7 -3.28E7 -2.02 -2.7905 -0.9997 1485 SPBio_002297 CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C20 compound treatment 9.6686184E7 -1.06E7 -0.6 1.03584655E8 -5700000.0 -0.35 -0.6762 -0.9667 3368 SPBio_002298 NC(=N)NC(=O)Cc1c(Cl)cccc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C21 compound treatment 9.2843323E7 -1.44E7 -0.82 9.7629683E7 -1.17E7 -0.72 -1.091 -0.9977 1000106 SPBio_002299 O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C22 compound treatment 9.294132E7 -1.43E7 -0.82 9.7065779E7 -1.22E7 -0.75 -1.1116 -0.9991 1001939 SPBio_002300 OCCN1CCN(CC/C=C\2/c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C23 mock treatment 9.0912967E7 -1.64E7 -0.93 9.3283983E7 -1.6E7 -0.99 -1.3585 -0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 C24 mock treatment 1.16025397E8 8760000.0 0.5 1.1878298E8 9500000.0 0.59 0.7678 0.997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D01 mock treatment 1.04553417E8 -2710000.0 -0.16 1.12618817E8 3330000.0 0.21 0.0355 0.1381 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D02 mock treatment 9.4716429E7 -1.26E7 -0.72 1.12062012E8 2770000.0 0.17 -0.3863 -0.5238 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D03 compound treatment 1.07976471E8 710000.0 0.04 1.11870435E8 2580000.0 0.16 0.1413 0.8597 3189308 SPBio_002301 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D04 compound treatment 9.8867535E7 -8400000.0 -0.48 9.9254581E7 -1.0E7 -0.62 -0.7767 -0.9922 2120971 SPBio_002302 CN1CCCC(CC2c3ccccc3Sc4ccccc24)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D05 compound treatment 2.9164161E7 -7.81E7 -4.46 2.9728487E7 -7.96E7 -4.9 -6.6241 -0.9989 2117676 SPBio_002303 COc1ccc(C[C@@H]2NC[C@@H](O)[C@@H]2OC(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D06 compound treatment 1.00657532E8 -6610000.0 -0.38 1.0552106E8 -3770000.0 -0.23 -0.4313 -0.9727 3172716 SPBio_002304 NC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D07 compound treatment 9.770055E7 -9570000.0 -0.55 1.03403101E8 -5880000.0 -0.36 -0.6431 -0.9801 1023517 SPBio_002305 NC(=O)Nc1ccc(cc1)[As](=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D08 compound treatment 9.6689777E7 -1.06E7 -0.6 1.01325693E8 -7960000.0 -0.49 -0.7745 -0.9947 1782 SPBio_002306 COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D09 compound treatment 8.3236984E7 -2.4E7 -1.37 9.0146245E7 -1.91E7 -1.18 -1.8054 -0.9971 360 SPBio_002307 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D10 compound treatment 9.7100783E7 -1.02E7 -0.58 9.4486614E7 -1.48E7 -0.91 -1.056 -0.9763 912 SPBio_002308 CCCc1cc(=O)[nH]c(=S)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D11 compound treatment 9.6104502E7 -1.12E7 -0.64 1.01709306E8 -7580000.0 -0.47 -0.7814 -0.9883 1064663 SPBio_002309 CC(=O)NC(CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D12 compound treatment 9.5867957E7 -1.14E7 -0.65 1.05337569E8 -3950000.0 -0.24 -0.6328 -0.9099 3189441 SPBio_002310 CC(C)N1CCN(CC1)c2ccc(OC[C@@H]3CO[C@](Cn4cncn4)(O3)c5ccc(Cl)cc5Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D13 compound treatment 9.4333774E7 -1.29E7 -0.74 9.9867558E7 -9420000.0 -0.58 -0.9333 -0.9929 3189309 SPBio_002311 CCOC(=O)OC(C)OC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D14 compound treatment 9.0681518E7 -1.66E7 -0.95 9.2587075E7 -1.67E7 -1.03 -1.3982 -0.9992 3487464 SPBio_002312 CC(C(=O)O)c1ccc(s1)C(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D15 compound treatment 9.1482961E7 -1.58E7 -0.9 9.5380659E7 -1.39E7 -0.86 -1.244 -0.9997 1960 SPBio_002313 CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D16 compound treatment 9.7190182E7 -1.01E7 -0.58 1.02878294E8 -6410000.0 -0.4 -0.6866 -0.9831 3177604 SPBio_002314 CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@H](NC6=O)C(=O)O)c3O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D17 compound treatment 9.3777232E7 -1.35E7 -0.77 9.4285441E7 -1.5E7 -0.92 -1.1991 -0.9959 951 SPBio_002315 OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D18 compound treatment 8.5816425E7 -2.15E7 -1.23 9.0236925E7 -1.91E7 -1.17 -1.6972 -0.9998 1263 SPBio_002316 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D19 compound treatment 9.4371732E7 -1.29E7 -0.74 9.277157E7 -1.65E7 -1.02 -1.241 -0.9874 982 SPBio_002317 CC(=O)Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D20 compound treatment 9.282206E7 -1.44E7 -0.83 9.3919504E7 -1.54E7 -0.95 -1.2536 -0.9976 1489 SPBio_002318 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D21 compound treatment 9.1834726E7 -1.54E7 -0.88 9.3816351E7 -1.55E7 -0.95 -1.298 -0.9992 3189310 SPBio_002319 CC(C)[C@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@H](O)CCC3=C)\CCC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D22 compound treatment 1.01901883E8 -5370000.0 -0.31 9.8354081E7 -1.09E7 -0.67 -0.6934 -0.9364 1113307 SPBio_002320 CCN(CC)C(=O)c1ccc(O)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D23 mock treatment 9.9315912E7 -7950000.0 -0.45 9.8141486E7 -1.11E7 -0.69 -0.8071 -0.9799 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 D24 mock treatment 1.100663E8 2800000.0 0.16 1.10510365E8 1220000.0 0.08 0.1664 0.9411 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E01 mock treatment 9.9195149E7 -8070000.0 -0.46 1.08041173E8 -1250000.0 -0.08 -0.3805 -0.8137 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E02 mock treatment 1.00587472E8 -6680000.0 -0.38 1.02169315E8 -7120000.0 -0.44 -0.5802 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E03 compound treatment 1.04605055E8 -2660000.0 -0.15 1.08747334E8 -540000.0 -0.03 -0.1311 -0.8419 3189178 SPBio_002321 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E04 compound treatment 1.03169931E8 -4100000.0 -0.23 1.07790046E8 -1500000.0 -0.09 -0.2308 -0.9172 1188 SPBio_002322 NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E05 compound treatment 9.880621E7 -8460000.0 -0.48 1.07107197E8 -2180000.0 -0.13 -0.4369 -0.8706 938 SPBio_002323 Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E06 compound treatment 9.6291936E7 -1.1E7 -0.63 1.01747309E8 -7540000.0 -0.46 -0.7722 -0.9891 1510 SPBio_002324 CN(C)CCN(Cc1cccs1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E07 compound treatment 9.5619745E7 -1.16E7 -0.67 1.03173919E8 -6110000.0 -0.38 -0.7372 -0.9637 3060494 SPBio_002325 CN(C)CC/C=C/1\c2ccccc2COc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E08 compound treatment 9.3750208E7 -1.35E7 -0.77 1.00717023E8 -8570000.0 -0.53 -0.9198 -0.9828 844 SPBio_002326 CNCCCN1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E09 compound treatment 9.6839155E7 -1.04E7 -0.6 1.05221606E8 -4070000.0 -0.25 -0.5986 -0.9259 1240 SPBio_002327 CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E10 compound treatment 9.0987722E7 -1.63E7 -0.93 9.0253202E7 -1.9E7 -1.17 -1.4875 -0.9934 2203 SPBio_002328 CN(CCCOc1ccc(Cl)cc1Cl)CC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E11 compound treatment 9.376693E7 -1.35E7 -0.77 9.8856434E7 -1.04E7 -0.64 -1.0002 -0.9959 3189179 SPBio_002329 CN(C)CCOC(c1ccccc1)c2ccccc2.Cn1c(=O)n(C)c2nc(Cl)[n-]c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E12 compound treatment 9.6518888E7 -1.07E7 -0.61 1.01509922E8 -7780000.0 -0.48 -0.7734 -0.9925 1390 SPBio_002330 CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E13 compound treatment 9.1546324E7 -1.57E7 -0.9 9.9442149E7 -9850000.0 -0.61 -1.0644 -0.9818 1112 SPBio_002331 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E14 compound treatment 8.0426245E7 -2.68E7 -1.53 8.2867608E7 -2.64E7 -1.63 -2.2363 -0.9996 1476 SPBio_002332 CNCCCC1(CCC2c3ccccc31)c4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E15 compound treatment 8.113431E7 -2.61E7 -1.49 8.9832161E7 -1.95E7 -1.2 -1.9041 -0.9941 1272 SPBio_002333 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E16 compound treatment 4.179879E7 -6.55E7 -3.74 4.3838206E7 -6.54E7 -4.03 -5.4985 -0.9993 3189187 SPBio_002334 Nc1nc(S)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E17 compound treatment 9.335944E7 -1.39E7 -0.79 1.03715192E8 -5570000.0 -0.34 -0.8049 -0.9296 2359 SPBio_002335 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@@H]32)n1c5ccccc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E18 compound treatment 9.6665876E7 -1.06E7 -0.61 9.5522094E7 -1.38E7 -0.85 -1.0284 -0.9864 3068882 SPBio_002336 CN(C)CC/C=C\1/c2ccccc2Sc3ccc(Cl)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E19 compound treatment 9.3733723E7 -1.35E7 -0.77 9.5875473E7 -1.34E7 -0.83 -1.1315 -0.9994 1393 SPBio_002337 CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E20 compound treatment 9.9613677E7 -7650000.0 -0.44 1.01559048E8 -7730000.0 -0.48 -0.6461 -0.9991 1000292 SPBio_002338 C[C@H](NCCc1ccc(O)cc1)[C@H](O)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E21 compound treatment 8.5463227E7 -2.18E7 -1.25 8.6552894E7 -2.27E7 -1.4 -1.8721 -0.9983 1215 SPBio_002339 CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E22 compound treatment 9.0247491E7 -1.7E7 -0.97 9.7070242E7 -1.22E7 -0.75 -1.2203 -0.992 417 SPBio_002340 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E23 mock treatment 9.3335301E7 -1.39E7 -0.8 9.3831566E7 -1.55E7 -0.95 -1.2367 -0.996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 E24 mock treatment 1.08426948E8 1160000.0 0.07 9.8575256E7 -1.07E7 -0.66 -0.42 -0.6329 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F01 mock treatment 1.15449208E8 8180000.0 0.47 1.08445357E8 -842000.0 -0.05 0.294 0.6248 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F02 mock treatment 1.09987941E8 2720000.0 0.16 1.14518178E8 5230000.0 0.32 0.338 0.9441 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F03 compound treatment 9.5802338E7 -1.15E7 -0.66 9.5173418E7 -1.41E7 -0.87 -1.0785 -0.9902 998 SPBio_002341 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F04 compound treatment 1.01884976E8 -5380000.0 -0.31 1.07643534E8 -1640000.0 -0.1 -0.2892 -0.8929 1002022 SPBio_002342 NC(CCC(=O)O)C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F05 compound treatment 9.7882649E7 -9380000.0 -0.54 1.0868041E8 -607000.0 -0.04 -0.4057 -0.7546 3069011 SPBio_002343 NCCC(=O)NCCc1c[nH]cn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F06 compound treatment 9.6330256E7 -1.09E7 -0.63 1.0072272E8 -8560000.0 -0.53 -0.8153 -0.9965 2121358 SPBio_002344 OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F07 compound treatment 9.8392948E7 -8870000.0 -0.51 1.0189968E8 -7390000.0 -0.46 -0.6806 -0.9986 1409 SPBio_002345 CCCC(C)(COC(=O)N)COC(=O)NC(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F08 compound treatment 9.7597657E7 -9670000.0 -0.55 1.04681535E8 -4610000.0 -0.28 -0.5915 -0.9521 3487465 SPBio_002346 OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F09 compound treatment 9.4871011E7 -1.24E7 -0.71 1.00848997E8 -8440000.0 -0.52 -0.8688 -0.9885 3189311 SPBio_002347 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](N)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F10 compound treatment 9.5220205E7 -1.2E7 -0.69 1.02898632E8 -6390000.0 -0.39 -0.7653 -0.9649 3189442 SPBio_002348 CCc1cccc(CC)c1NC(=O)CN(CC(=O)O)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F11 compound treatment 9.1927129E7 -1.53E7 -0.88 9.9382606E7 -9900000.0 -0.61 -1.0516 -0.9844 2117409 SPBio_002349 COc1cc(ccc1N=Nc2ccc3c(cc(c(N)c3c2O)S(=O)(=O)O)S(=O)(=O)O)c4ccc(N=Nc5ccc6c(cc(c(N)c6c5O)S(=O)(=O)O)S(=O)(=O)O)c(OC)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F12 compound treatment 9.3560283E7 -1.37E7 -0.78 9.8794594E7 -1.05E7 -0.65 -1.0113 -0.9955 1252 SPBio_002350 CC(C)NCC(O)c1cc(O)cc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F13 compound treatment 9.4895642E7 -1.24E7 -0.71 9.9062534E7 -1.02E7 -0.63 -0.9456 -0.9984 907205 SPBio_002351 COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F14 compound treatment 9.6789058E7 -1.05E7 -0.6 1.01746364E8 -7540000.0 -0.46 -0.7521 -0.9922 2080587 SPBio_002352 CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(=CCC3N)CN)C2O)OCC1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F15 compound treatment 9.5733461E7 -1.15E7 -0.66 9.8221489E7 -1.11E7 -0.68 -0.9484 -0.9999 3173763 SPBio_002353 O[C@@H]1C[C@](O)(C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H]1O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F16 compound treatment 6.9153944E7 -3.81E7 -2.18 6.6492212E7 -4.28E7 -2.64 -3.4056 -0.9955 353 SPBio_002354 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F17 compound treatment 3.1876374E7 -7.54E7 -4.31 3.3998368E7 -7.53E7 -4.64 -6.3284 -0.9993 3180147 SPBio_002355 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]4NCCc5cc(O)c(OC)cc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F18 compound treatment 9.0605991E7 -1.67E7 -0.95 9.2577661E7 -1.67E7 -1.03 -1.4016 -0.9992 2269 SPBio_002356 Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F19 compound treatment 9.9813063E7 -7450000.0 -0.43 1.03477278E8 -5810000.0 -0.36 -0.5545 -0.9963 3189312 SPBio_002357 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C\3/C[C@H](O)CCC3=C)/CCC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F20 compound treatment 9.8711862E7 -8560000.0 -0.49 1.04875291E8 -4410000.0 -0.27 -0.538 -0.9617 2922 SPBio_002358 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Br)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F21 compound treatment 9.5885783E7 -1.14E7 -0.65 9.848299E7 -1.08E7 -0.67 -0.9309 -0.9999 3487430 SPBio_002359 COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c3cc(Cl)c(N)cc3OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F22 compound treatment 9.3721296E7 -1.35E7 -0.77 9.5490384E7 -1.38E7 -0.85 -1.1488 -0.9989 1000807 SPBio_002360 CN1CCN(CC1)C(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F23 mock treatment 9.814627E7 -9120000.0 -0.52 9.6561768E7 -1.27E7 -0.78 -0.9233 -0.9803 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 F24 mock treatment 1.04661228E8 -2610000.0 -0.15 1.0068459E8 -8600000.0 -0.53 -0.4803 -0.8719 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G01 mock treatment 1.01465887E8 -5800000.0 -0.33 1.15995118E8 6710000.0 0.41 0.0579 0.1093 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G02 mock treatment 1.14932815E8 7670000.0 0.44 1.10604004E8 1320000.0 0.08 0.3672 0.8241 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G03 compound treatment 1.12573196E8 5310000.0 0.3 1.16542853E8 7260000.0 0.45 0.5307 0.9821 3069234 SPBio_002361 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@](O)(C(=O)OC)n4c5ccccc35 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G04 compound treatment 1.09602297E8 2340000.0 0.13 1.13103204E8 3820000.0 0.24 0.2607 0.964 1332 SPBio_002362 NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G05 compound treatment 1.06861269E8 -406000.0 -0.02 1.12295344E8 3010000.0 0.19 0.1147 0.6139 2797 SPBio_002363 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G06 compound treatment 9.6978857E7 -1.03E7 -0.59 1.0359731E8 -5690000.0 -0.35 -0.6638 -0.9695 3480458 SPBio_002364 CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G07 compound treatment 1.0680664E8 -460000.0 -0.03 1.07737607E8 -1550000.0 -0.1 -0.0862 -0.8695 3176928 SPBio_002365 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G08 compound treatment 1.0716364E8 -103000.0 -0.01 1.07632192E8 -1660000.0 -0.1 -0.0763 -0.7468 1048 SPBio_002366 CCn1cc(C(=O)O)c(=O)c2cc(F)c(nc12)N3CCNCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G09 compound treatment 3.7307572E7 -7.0E7 -4.0 3.9199999E7 -7.01E7 -4.32 -5.8822 -0.9993 3189180 SPBio_002367 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G10 compound treatment 1.02236028E8 -5030000.0 -0.29 1.04898568E8 -4390000.0 -0.27 -0.3946 -0.9995 1526 SPBio_002368 CC1CCCC(C)N1NC(=O)c2ccc(Cl)c(c2)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G11 compound treatment 1.05511349E8 -1760000.0 -0.1 1.097652E8 478000.0 0.03 -0.0501 -0.4793 1172 SPBio_002369 CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G12 compound treatment 5.4278778E7 -5.3E7 -3.03 6.0501282E7 -4.88E7 -3.01 -4.2679 -1.0 1105 SPBio_002370 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G13 compound treatment 1.0133533E8 -5930000.0 -0.34 1.04646752E8 -4640000.0 -0.29 -0.442 -0.9964 404 SPBio_002371 CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G14 compound treatment 1.0496171E8 -2310000.0 -0.13 1.07359488E8 -1930000.0 -0.12 -0.1772 -0.9987 3068883 SPBio_002372 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G15 compound treatment 1.0430677E8 -2960000.0 -0.17 1.07129125E8 -2160000.0 -0.13 -0.2137 -0.9929 1100 SPBio_002373 CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G16 compound treatment 1.05695253E8 -1570000.0 -0.09 1.04759091E8 -4530000.0 -0.28 -0.2609 -0.8897 3189189 SPBio_002374 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G17 compound treatment 1.13636199E8 6370000.0 0.36 1.12381615E8 3090000.0 0.19 0.3923 0.9545 3172 SPBio_002375 C(/C=C/c1ccccc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G18 compound treatment 1.08433843E8 1170000.0 0.07 1.07948132E8 -1340000.0 -0.08 -0.0112 -0.1057 1000342 SPBio_002376 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G19 compound treatment 3.5402005E7 -7.19E7 -4.11 3.5723255E7 -7.36E7 -4.53 -6.1107 -0.9988 1001967 SPBio_002377 C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G20 compound treatment 1.08396707E8 1130000.0 0.06 1.08175374E8 -1110000.0 -0.07 -0.0028 -0.0299 1000343 SPBio_002378 COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G21 compound treatment 3.3492299E7 -7.38E7 -4.22 3.3860914E7 -7.54E7 -4.65 -6.2691 -0.9988 3177396 SPBio_002379 COc1ccc2nccc([C@H](O)[C@H]3CC4CCN3C[C@@H]4C=C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G22 compound treatment 1.12719213E8 5450000.0 0.31 1.04338513E8 -4950000.0 -0.31 0.0046 0.0106 764 SPBio_002380 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)n3c(=O)[nH]c4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G23 mock treatment 1.00526621E8 -6740000.0 -0.39 9.9709272E7 -9580000.0 -0.59 -0.6899 -0.9786 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 G24 mock treatment 1.12321764E8 5050000.0 0.29 1.03329031E8 -5960000.0 -0.37 -0.0554 -0.1186 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H01 mock treatment 1.06860538E8 -406000.0 -0.02 1.1781488E8 8530000.0 0.53 0.3553 0.6752 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H02 mock treatment 1.0827973E8 1010000.0 0.06 1.14522445E8 5240000.0 0.32 0.2691 0.8208 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H03 compound treatment 1.05938314E8 -1330000.0 -0.08 1.14449206E8 5160000.0 0.32 0.1713 0.5237 1055132 SPBio_002381 COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H04 compound treatment 1.03222554E8 -4040000.0 -0.23 1.08420712E8 -867000.0 -0.05 -0.2012 -0.8482 1095093 SPBio_002382 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H05 compound treatment 8.3632862E7 -2.36E7 -1.35 8.7286522E7 -2.2E7 -1.36 -1.9141 -1.0 3054850 SPBio_002383 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H06 compound treatment 1.04982716E8 -2280000.0 -0.13 1.09953655E8 666000.0 0.04 -0.0633 -0.4623 2141046 SPBio_002384 CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H07 compound treatment 1.02218218E8 -5050000.0 -0.29 1.08150704E8 -1140000.0 -0.07 -0.2536 -0.854 3189313 SPBio_002385 C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(=O)N)[C@H]2N=C1/C(=C/3\N=C(/C=C/4\N=C(/C(=C\5/[C@@H](CCC(=O)N)[C@](C)(CC(=O)N)[C@@]2(C)N5[Co+]C#N)/C)\[C@@](C)(CC(=O)N)[C@@H]4CCC(=O)N)\C(C)(C)[C@@H]3CCC(=O)N)/C)OP(=O)(O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H08 compound treatment 9.5676711E7 -1.16E7 -0.66 9.1570645E7 -1.77E7 -1.09 -1.2406 -0.9713 3068692 SPBio_002386 CNCCC=C1c2ccccc2C=Cc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H09 compound treatment 1.0272201E8 -4540000.0 -0.26 1.06825757E8 -2460000.0 -0.15 -0.291 -0.9672 1037 SPBio_002387 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H10 compound treatment 1.02243196E8 -5020000.0 -0.29 1.05932288E8 -3360000.0 -0.21 -0.3493 -0.987 889 SPBio_002388 NC(=O)c1cnccn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H11 compound treatment 1.02731015E8 -4540000.0 -0.26 1.0555404E8 -3730000.0 -0.23 -0.346 -0.9982 3069049 SPBio_002389 CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C/C=C/C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H12 compound treatment 9.8360692E7 -8910000.0 -0.51 1.02906353E8 -6380000.0 -0.39 -0.6381 -0.9919 2900 SPBio_002390 CN1C(=O)OC(C)(C)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H13 compound treatment 2.9551879E7 -7.77E7 -4.44 2.9469814E7 -7.98E7 -4.92 -6.6197 -0.9987 3189314 SPBio_002391 C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)CC[C@@H]1C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H14 compound treatment 9.070733E7 -1.66E7 -0.95 9.6034767E7 -1.33E7 -0.82 -1.2469 -0.9973 1607 SPBio_002392 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H15 compound treatment 2.9149645E7 -7.81E7 -4.46 2.9015528E7 -8.03E7 -4.95 -6.6558 -0.9987 3189315 SPBio_002393 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H16 compound treatment 1.05372214E8 -1890000.0 -0.11 1.00998061E8 -8290000.0 -0.51 -0.4379 -0.8383 3189443 SPBio_002394 CC1OC(OC/2CC3O[C@@](O)(CC(O)C3C(=O)O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)/C=C/C=C/CC\C=C\C=C\C=C\C=C2)C(O)C(N)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H17 compound treatment 2.9174763E7 -7.81E7 -4.46 2.8949019E7 -8.03E7 -4.95 -6.6577 -0.9987 1000279 SPBio_002395 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H18 compound treatment 3.5520828E7 -7.17E7 -4.1 3.5979029E7 -7.33E7 -4.52 -6.0948 -0.9988 3060147 SPBio_002396 CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H19 compound treatment 1.025005E8 -4770000.0 -0.27 9.9677895E7 -9610000.0 -0.59 -0.6115 -0.9379 3069053 SPBio_002397 CCOC(=O)n1ccn(C)c1=S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H20 compound treatment 1.05938896E8 -1330000.0 -0.08 1.05034055E8 -4250000.0 -0.26 -0.2391 -0.8758 3068724 SPBio_002398 C[C@@H](O)[C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCNC=N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H21 compound treatment 1.07330817E8 63900.0 0.0 1.01385521E8 -7900000.0 -0.49 -0.3418 -0.7018 1001924 SPBio_002399 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H22 compound treatment 1.03765128E8 -3500000.0 -0.2 9.4250427E7 -1.5E7 -0.93 -0.7969 -0.8404 1448 SPBio_002400 OC(=O)c1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H23 mock treatment 1.1316826E8 5900000.0 0.34 1.06994046E8 -2290000.0 -0.14 0.1385 0.3788 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 H24 mock treatment 1.13592056E8 6330000.0 0.36 1.05125248E8 -4160000.0 -0.26 0.0742 0.1674 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I01 mock treatment 1.04600318E8 -2670000.0 -0.15 1.20631198E8 1.13E7 0.7 0.3867 0.5403 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I02 mock treatment 1.1031121E8 3040000.0 0.17 1.16174571E8 6890000.0 0.42 0.4232 0.9224 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I03 compound treatment 3.8762884E7 -6.85E7 -3.92 3.9695422E7 -6.96E7 -4.29 -5.8018 -0.999 1000235 SPBio_002401 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I04 compound treatment 1.06299811E8 -967000.0 -0.06 1.13753159E8 4470000.0 0.28 0.1556 0.5541 3189191 SPBio_002402 CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I05 compound treatment 1.04247033E8 -3020000.0 -0.17 1.14652883E8 5370000.0 0.33 0.1118 0.2998 1033 SPBio_002403 CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I06 compound treatment 3.311373E7 -7.42E7 -4.24 3.4665366E7 -7.46E7 -4.6 -6.2493 -0.9992 3068885 SPBio_002404 C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I07 compound treatment 8.9696959E7 -1.76E7 -1.0 9.7493383E7 -1.18E7 -0.73 -1.2241 -0.9874 1019722 SPBio_002405 CN1CCCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I08 compound treatment 4.230667E7 -6.5E7 -3.71 4.3624497E7 -6.57E7 -4.05 -5.4873 -0.9991 1352 SPBio_002406 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I09 compound treatment 9.1173432E7 -1.61E7 -0.92 9.6951726E7 -1.23E7 -0.76 -1.1881 -0.9955 1164 SPBio_002407 CCN(CC)C(=O)N1CCN(C)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I10 compound treatment 9.0892815E7 -1.64E7 -0.94 9.0204912E7 -1.91E7 -1.18 -1.4935 -0.9936 3177235 SPBio_002408 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]3[C@H]1Cc4cn(C)c5cccc3c45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I11 compound treatment 9.8853627E7 -8410000.0 -0.48 1.05336165E8 -3950000.0 -0.24 -0.5122 -0.9503 1000071 SPBio_002409 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I12 compound treatment 9.7334516E7 -9930000.0 -0.57 1.01034738E8 -8250000.0 -0.51 -0.7611 -0.9985 3189192 SPBio_002410 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I13 compound treatment 8.9523059E7 -1.77E7 -1.01 7.8556869E7 -3.07E7 -1.89 -2.0566 -0.9571 1158 SPBio_002411 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I14 compound treatment 1.02555621E8 -4710000.0 -0.27 1.06734131E8 -2550000.0 -0.16 -0.3017 -0.9673 701 SPBio_002412 Nc1c(Br)cc(Br)cc1CNC2CCC(O)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I15 compound treatment 1.10049357E8 2780000.0 0.16 1.14312905E8 5030000.0 0.31 0.3315 0.952 3480597 SPBio_002413 CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I16 compound treatment 1.07246975E8 -20000.0 0.0 1.06030749E8 -3260000.0 -0.2 -0.1428 -0.7111 705 SPBio_002414 CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I17 compound treatment 1.10415922E8 3150000.0 0.18 1.07522112E8 -1770000.0 -0.11 0.0503 0.2392 1180 SPBio_002415 Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I18 compound treatment 8.6403764E7 -2.09E7 -1.19 7.9397341E7 -2.99E7 -1.84 -2.146 -0.9778 1000048 SPBio_002416 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I19 compound treatment 1.05498627E8 -1770000.0 -0.1 1.03682711E8 -5600000.0 -0.35 -0.3158 -0.8772 830 SPBio_002417 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I20 compound treatment 1.11362458E8 4100000.0 0.23 1.06792213E8 -2500000.0 -0.15 0.0567 0.2026 1504 SPBio_002418 O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I21 compound treatment 1.03639226E8 -3630000.0 -0.21 1.01003376E8 -8280000.0 -0.51 -0.5077 -0.9212 753 SPBio_002419 O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I22 compound treatment 1.01845393E8 -5420000.0 -0.31 1.0131524E8 -7970000.0 -0.49 -0.5666 -0.9753 2873 SPBio_002420 CCc1oc2ccccc2c1C(=O)c3cc(Br)c(O)c(Br)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I23 mock treatment 1.0820383E8 937000.0 0.05 1.0331082E8 -5980000.0 -0.37 -0.2226 -0.5981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 I24 mock treatment 1.16031035E8 8760000.0 0.5 1.13466572E8 4180000.0 0.26 0.5363 0.9522 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J01 mock treatment 1.06850683E8 -416000.0 -0.02 1.20850574E8 1.16E7 0.71 0.4872 0.6831 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J02 mock treatment 1.1228546E8 5020000.0 0.29 1.15817784E8 6530000.0 0.4 0.4875 0.9862 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J03 compound treatment 1.00626034E8 -6640000.0 -0.38 1.0105295E8 -8230000.0 -0.51 -0.6273 -0.9897 386 SPBio_002421 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2CC[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J04 compound treatment 1.08466418E8 1200000.0 0.07 1.10967091E8 1680000.0 0.1 0.1217 0.98 821975 SPBio_002422 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J05 compound treatment 1.04437186E8 -2830000.0 -0.16 1.03334324E8 -5950000.0 -0.37 -0.3738 -0.9322 2078 SPBio_002423 CCCCc1ccc(nc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J06 compound treatment 3.3945587E7 -7.33E7 -4.19 3.5107892E7 -7.42E7 -4.57 -6.1964 -0.9991 3189444 SPBio_002424 CCC(C)C1NC2C=Cc3c(cc(nc3C2O)C(=O)OC(C)C4NC(=O)c5csc(n5)C(NC(=O)C6CSC(=N6)/C(=C\C)/NC(=O)C(NC(=O)c7csc(n7)C8(CCC(=NC8c9csc4n9)c%10nc(cs%10)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)C(C)(O)C(C)O)C(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J07 compound treatment 9.6575916E7 -1.07E7 -0.61 1.01599686E8 -7690000.0 -0.47 -0.7671 -0.9921 3189316 SPBio_002425 COc1ccc(cc1)c2ccc(=N)n(CCCC(=O)O)n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J08 compound treatment 1.00099887E8 -7170000.0 -0.41 1.07445216E8 -1840000.0 -0.11 -0.3699 -0.8703 3068727 SPBio_002426 C[S+](=N)([O-])CC[C@H](N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J09 compound treatment 1.01945503E8 -5320000.0 -0.3 1.09164637E8 -123000.0 -0.01 -0.2204 -0.7245 3189317 SPBio_002427 C[C@@H]1C(=O)O[C@H]2CC34[C@H]5C[C@@H](C(C)(C)C)C46[C@@H](O)C(=O)O[C@H]6OC3(C(=O)O5)[C@@]12O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J10 compound treatment 9.9151334E7 -8120000.0 -0.46 9.866101E7 -1.06E7 -0.66 -0.7912 -0.9857 737 SPBio_002428 c1nc(cs1)c2nc3ccccc3[nH]2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J11 compound treatment 9.7331114E7 -9940000.0 -0.57 9.7224897E7 -1.21E7 -0.74 -0.9273 -0.9911 716 SPBio_002429 CN(C)CCC=C1c2ccccc2C=Cc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J12 compound treatment 1.02176716E8 -5090000.0 -0.29 1.0700928E8 -2280000.0 -0.14 -0.305 -0.9442 3189445 SPBio_002430 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4c(O)c(/C=N/N5CCN(C)CC5)c(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)c(O)c4c(O)c3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J13 compound treatment 9.7587902E7 -9680000.0 -0.55 1.02111069E8 -7180000.0 -0.44 -0.704 -0.9939 1300555 SPBio_002431 CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J14 compound treatment 1.01901512E8 -5370000.0 -0.31 1.05814516E8 -3470000.0 -0.21 -0.3682 -0.9846 803 SPBio_002432 CCc1cc(ccn1)C(=S)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J15 compound treatment 4.731752E7 -5.99E7 -3.43 4.9620463E7 -5.97E7 -3.68 -5.0234 -0.9994 2080102 SPBio_002433 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J16 compound treatment 1.02179186E8 -5090000.0 -0.29 1.0442593E8 -4860000.0 -0.3 -0.4175 -0.9999 900 SPBio_002434 CN1C(=C(O)c2sccc2S1(=O)=O)C(=O)Nc3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J17 compound treatment 1.04407947E8 -2860000.0 -0.16 1.08269911E8 -1020000.0 -0.06 -0.1599 -0.9135 3069083 SPBio_002435 Nc1c2ccccc2nc3c(O)cccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J18 compound treatment 1.0154484E8 -5720000.0 -0.33 1.03435457E8 -5850000.0 -0.36 -0.4863 -0.9988 3068731 SPBio_002436 CC(=O)Oc1cc(ccc1C(=O)O)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J19 compound treatment 1.05194243E8 -2070000.0 -0.12 1.02575539E8 -6710000.0 -0.41 -0.3763 -0.8744 992 SPBio_002437 CC[C@H]1[C@@H](Cc2cncn2C)COC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J20 compound treatment 1.12081068E8 4810000.0 0.28 1.08078486E8 -1210000.0 -0.07 0.1419 0.4977 4379 SPBio_002438 CN1CCCCC1CCN2c3ccccc3Sc4ccc(cc24)S(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J21 compound treatment 1.04758168E8 -2510000.0 -0.14 1.04845187E8 -4440000.0 -0.27 -0.295 -0.9544 1265 SPBio_002439 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4c(Cl)cccc4Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J22 compound treatment 9.9401994E7 -7860000.0 -0.45 9.6014143E7 -1.33E7 -0.82 -0.8964 -0.9602 1470254 SPBio_002440 Cc1c(C)c2OC(C)(CCc2c(C)c1O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J23 mock treatment 1.15858491E8 8590000.0 0.49 1.15075473E8 5790000.0 0.36 0.5995 0.9877 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 J24 mock treatment 1.12770542E8 5500000.0 0.31 1.11417303E8 2130000.0 0.13 0.3153 0.9249 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K01 mock treatment 9.9178823E7 -8090000.0 -0.46 1.15228831E8 5940000.0 0.37 -0.0679 -0.1151 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K02 mock treatment 1.05404905E8 -1860000.0 -0.11 1.04028146E8 -5260000.0 -0.32 -0.3045 -0.8924 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K03 compound treatment 1.03098999E8 -4170000.0 -0.24 1.03931373E8 -5360000.0 -0.33 -0.4019 -0.9872 3068677 SPBio_002441 OC1=NC(=O)CN1/N=C/c2ccc(o2)c3ccc(cc3)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K04 compound treatment 1.07712905E8 446000.0 0.03 1.04516375E8 -4770000.0 -0.29 -0.1899 -0.6434 771 SPBio_002442 CN1CCC(=C2c3ccsc3C(=O)Cc4ccccc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K05 compound treatment 1.00776716E8 -6490000.0 -0.37 1.01714823E8 -7570000.0 -0.47 -0.5924 -0.9935 850 SPBio_002443 Clc1cccc(c1)N2CCN(CCCn3nc4ccccn4c3=O)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K06 compound treatment 9.8165163E7 -9100000.0 -0.52 1.01529961E8 -7760000.0 -0.48 -0.706 -0.9991 907283 SPBio_002444 NC(=N)N1CCc2ccccc2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K07 compound treatment 9.1660558E7 -1.56E7 -0.89 9.1438004E7 -1.78E7 -1.1 -1.4087 -0.9946 936 SPBio_002445 OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K08 compound treatment 3.9596699E7 -6.77E7 -3.87 4.7153378E7 -6.21E7 -3.83 -5.443 -1.0 1000064 SPBio_002446 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K09 compound treatment 9.2759695E7 -1.45E7 -0.83 9.6848312E7 -1.24E7 -0.77 -1.1285 -0.9992 1060 SPBio_002447 CN1CCC(=C2c3ccccc3Sc4ccccc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K10 compound treatment 9.7923017E7 -9340000.0 -0.53 9.931374E7 -9970000.0 -0.61 -0.8123 -0.9975 3189193 SPBio_002448 CC[C@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K11 compound treatment 9.8345448E7 -8920000.0 -0.51 1.03783552E8 -5500000.0 -0.34 -0.6004 -0.9804 1069 SPBio_002449 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K12 compound treatment 8.438101E7 -2.29E7 -1.31 8.1726196E7 -2.76E7 -1.7 -2.1262 -0.9917 1496 SPBio_002450 CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K13 compound treatment 9.5975878E7 -1.13E7 -0.65 9.5184156E7 -1.41E7 -0.87 -1.071 -0.9892 1113 SPBio_002451 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(=O)O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K14 compound treatment 7.0288835E7 -3.7E7 -2.11 7.042312E7 -3.89E7 -2.4 -3.1884 -0.998 3068886 SPBio_002452 CC(C)/N=c/1\cc2n(c3ccc(Cl)cc3)c4ccccc4nc2cc1Nc5ccc(Cl)cc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K15 compound treatment 1.06400914E8 -866000.0 -0.05 1.05636228E8 -3650000.0 -0.23 -0.1941 -0.8425 3068682 SPBio_002453 CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K16 compound treatment 1.01843673E8 -5420000.0 -0.31 9.9340792E7 -9950000.0 -0.61 -0.6527 -0.9501 975 SPBio_002454 CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K17 compound treatment 1.03029041E8 -4240000.0 -0.24 1.01807639E8 -7480000.0 -0.46 -0.4973 -0.9548 1348 SPBio_002455 Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K18 compound treatment 1.05185561E8 -2080000.0 -0.12 1.05166113E8 -4120000.0 -0.25 -0.2638 -0.9402 1000105 SPBio_002456 CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K19 compound treatment 9.7442066E7 -9820000.0 -0.56 9.9793044E7 -9490000.0 -0.59 -0.8109 -0.9998 3055129 SPBio_002457 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@@]21C)c5ccc(cc5)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K20 compound treatment 1.04119094E8 -3150000.0 -0.18 1.02408736E8 -6880000.0 -0.42 -0.427 -0.9271 1000143 SPBio_002458 NC(Cn1ccc(=O)c(O)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K21 compound treatment 1.02885613E8 -4380000.0 -0.25 1.02604106E8 -6680000.0 -0.41 -0.4684 -0.9715 1045066 SPBio_002459 O=C(Nc1ccccc1)OCC(CN2CCCCC2)OC(=O)Nc3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K22 compound treatment 1.01485616E8 -5780000.0 -0.33 9.750174E7 -1.18E7 -0.73 -0.7473 -0.9364 2777 SPBio_002460 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K23 mock treatment 1.01582486E8 -5680000.0 -0.32 9.3986487E7 -1.53E7 -0.94 -0.8967 -0.8988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 K24 mock treatment 1.03945368E8 -3320000.0 -0.19 1.06674245E8 -2610000.0 -0.16 -0.2481 -0.9967 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L01 mock treatment 1.10858142E8 3590000.0 0.21 1.13644595E8 4360000.0 0.27 0.335 0.9912 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L02 mock treatment 9.4710891E7 -1.26E7 -0.72 1.04142223E8 -5150000.0 -0.32 -0.7317 -0.9326 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L03 compound treatment 1.0212416E8 -5140000.0 -0.29 1.10407724E8 1120000.0 0.07 -0.159 -0.5266 1055159 SPBio_002461 NC(CC(=O)c1cccc(O)c1N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L04 compound treatment 1.08879164E8 1610000.0 0.09 1.08044431E8 -1240000.0 -0.08 0.011 0.0916 907463 SPBio_002462 Cc1nc2ccccn2c(=O)c1CCN3CCC(CC3)C(=O)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L05 compound treatment 1.03394877E8 -3870000.0 -0.22 1.04543708E8 -4740000.0 -0.29 -0.3632 -0.9906 3189433 SPBio_002463 OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L06 compound treatment 1.01806758E8 -5460000.0 -0.31 1.01656515E8 -7630000.0 -0.47 -0.5533 -0.9801 1024517 SPBio_002464 COc1cc2CCNC(C)c2cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L07 compound treatment 9.8498312E7 -8770000.0 -0.5 9.8735958E7 -1.06E7 -0.65 -0.8143 -0.9917 3069088 SPBio_002465 COC1=C[C@@H]2[C@@H](C3=C2c4c(OC)c(OC)c(OC)cc4CC[C@@H]3NC(=O)C)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L08 compound treatment 1.00718415E8 -6550000.0 -0.37 9.9176261E7 -1.01E7 -0.62 -0.7054 -0.9702 1193 SPBio_002466 CCOc1ccc(NC(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L09 compound treatment 9.7550687E7 -9720000.0 -0.56 9.7361584E7 -1.19E7 -0.74 -0.9125 -0.9904 1134 SPBio_002467 CN1C[C@H](CO)C=C2[C@H]1Cc3c[nH]c4cccc2c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L10 compound treatment 9.6272185E7 -1.1E7 -0.63 1.00899272E8 -8390000.0 -0.52 -0.8099 -0.9953 3474094 SPBio_002468 OC1=C(C2CCC(CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L11 compound treatment 9.9382723E7 -7880000.0 -0.45 9.5731702E7 -1.36E7 -0.84 -0.9095 -0.958 3174101 SPBio_002469 CN1CCc2c(C1)c3ccccc3n2Cc4ccccc4.OS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L12 compound treatment 9.644722E7 -1.08E7 -0.62 1.00681961E8 -8610000.0 -0.53 -0.8123 -0.9971 3058468 SPBio_002470 COc1ccc(OC)c(c1)C(O)C(C)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L13 compound treatment 9.5870853E7 -1.14E7 -0.65 9.2268784E7 -1.7E7 -1.05 -1.2023 -0.9737 3174345 SPBio_002471 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N.OC(=O)c1cc(ccc1O)S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L14 compound treatment 9.2880964E7 -1.44E7 -0.82 9.67928E7 -1.25E7 -0.77 -1.126 -0.9995 1001858 SPBio_002472 CC(C)NC[C@H](O)COc1ccc(CC(=O)N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L15 compound treatment 1.05651364E8 -1620000.0 -0.09 1.02888548E8 -6400000.0 -0.39 -0.3442 -0.8497 1035 SPBio_002473 Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L16 compound treatment 1.00206976E8 -7060000.0 -0.4 9.7994011E7 -1.13E7 -0.7 -0.7776 -0.9664 904 SPBio_002474 NC(=O)CN1CCCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L17 compound treatment 1.01757583E8 -5510000.0 -0.31 1.01892809E8 -7390000.0 -0.46 -0.545 -0.9837 988 SPBio_002475 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L18 compound treatment 1.03209744E8 -4060000.0 -0.23 9.9225238E7 -1.01E7 -0.62 -0.6025 -0.9099 948 SPBio_002476 O=C1C(C(=O)c2ccccc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L19 compound treatment 2.9137083E7 -7.81E7 -4.47 2.8948161E7 -8.03E7 -4.95 -6.6592 -0.9987 449 SPBio_002477 CC1=CC(=O)c2ccccc2C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L20 compound treatment 1.03124961E8 -4140000.0 -0.24 1.05613484E8 -3670000.0 -0.23 -0.3275 -0.9998 3189446 SPBio_002478 COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc3CCC(NC(=O)C)c4cc(=O)c(SC)ccc4-c3c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L21 compound treatment 9.7866082E7 -9400000.0 -0.54 9.9297209E7 -9990000.0 -0.62 -0.8154 -0.9977 3069122 SPBio_002479 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O.COC(N)(CO)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L22 compound treatment 9.6195865E7 -1.11E7 -0.63 9.3562867E7 -1.57E7 -0.97 -1.1328 -0.9786 3068774 SPBio_002480 Nc1cc(C(=C(Cl)Cl)Cl)c(cc1S(=O)(=O)N)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L23 mock treatment 1.02612354E8 -4650000.0 -0.27 9.8283252E7 -1.1E7 -0.68 -0.6678 -0.9165 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 L24 mock treatment 1.03349719E8 -3920000.0 -0.22 1.06138456E8 -3150000.0 -0.19 -0.2956 -0.9975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M01 mock treatment 1.2043708E8 1.32E7 0.75 1.22349555E8 1.31E7 0.81 1.1016 0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M02 mock treatment 1.1185039E8 4580000.0 0.26 1.08920521E8 -367000.0 -0.02 0.1692 0.6437 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M03 compound treatment 1.04005571E8 -3260000.0 -0.19 1.06587781E8 -2700000.0 -0.17 -0.2495 -0.9984 1608 SPBio_002481 NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M04 compound treatment 9.3886662E7 -1.34E7 -0.76 9.8092729E7 -1.12E7 -0.69 -1.0287 -0.9987 907366 SPBio_002482 Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M05 compound treatment 9.3322124E7 -1.39E7 -0.8 9.6305194E7 -1.3E7 -0.8 -1.1294 -1.0 3068878 SPBio_002483 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M06 compound treatment 1.00465151E8 -6800000.0 -0.39 1.02745566E8 -6540000.0 -0.4 -0.56 -0.9998 3480396 SPBio_002484 CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M07 compound treatment 9.9688392E7 -7580000.0 -0.43 1.01348159E8 -7940000.0 -0.49 -0.6523 -0.9981 907526 SPBio_002485 CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc4ccccc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M08 compound treatment 9.476233E7 -1.25E7 -0.71 9.9885161E7 -9400000.0 -0.58 -0.9152 -0.9946 86 SPBio_002486 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCN(C)Cc3ccccc3)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M09 compound treatment 8.5526861E7 -2.17E7 -1.24 9.3155945E7 -1.61E7 -0.99 -1.5817 -0.9939 773 SPBio_002487 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M10 compound treatment 9.4819523E7 -1.24E7 -0.71 9.4929067E7 -1.44E7 -0.89 -1.1289 -0.9941 1210 SPBio_002488 CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M11 compound treatment 9.0268031E7 -1.7E7 -0.97 9.3351641E7 -1.59E7 -0.98 -1.3816 -1.0 1357 SPBio_002489 CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M12 compound treatment 3.0416942E7 -7.68E7 -4.39 3.0356156E7 -7.89E7 -4.87 -6.5461 -0.9987 1135 SPBio_002490 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M13 compound treatment 8.5100373E7 -2.22E7 -1.27 7.9532845E7 -2.98E7 -1.83 -2.1927 -0.9837 927 SPBio_002491 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M14 compound treatment 5.7270867E7 -5.0E7 -2.86 5.5429918E7 -5.39E7 -3.32 -4.368 -0.9972 907273 SPBio_002492 Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M15 compound treatment 9.5213428E7 -1.21E7 -0.69 9.7602634E7 -1.17E7 -0.72 -0.9964 -0.9998 876 SPBio_002493 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M16 compound treatment 1.00880383E8 -6390000.0 -0.37 9.6495814E7 -1.28E7 -0.79 -0.8157 -0.9387 990 SPBio_002494 CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M17 compound treatment 8.4407749E7 -2.29E7 -1.31 8.6915327E7 -2.24E7 -1.38 -1.8989 -0.9996 2117626 SPBio_002495 Fc1ccc(cc1)C(CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34)c5ccc(F)cc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M18 compound treatment 8.9843468E7 -1.74E7 -1.0 8.5853153E7 -2.34E7 -1.44 -1.7256 -0.9835 1351 SPBio_002496 Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M19 compound treatment 8.1747191E7 -2.55E7 -1.46 8.5540012E7 -2.37E7 -1.46 -2.0664 -1.0 467359 SPBio_002497 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M20 compound treatment 8.8171768E7 -1.91E7 -1.09 9.9186439E7 -1.01E7 -0.62 -1.212 -0.9646 3060108 SPBio_002498 CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M21 compound treatment 1.00597033E8 -6670000.0 -0.38 9.7580859E7 -1.17E7 -0.72 -0.7798 -0.9555 714 SPBio_002499 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc2ccc(OC)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M22 compound treatment 9.7266704E7 -1.0E7 -0.57 9.4394892E7 -1.49E7 -0.92 -1.0533 -0.974 1000211 SPBio_002500 C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@H]2[C@H](O)C[C@H]4/C(=C(\CCC=C(C)C)/C(=O)O)/[C@H](C[C@@]43C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M23 mock treatment 9.397261E7 -1.33E7 -0.76 9.2235987E7 -1.71E7 -1.05 -1.2805 -0.9873 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 M24 mock treatment 1.04189539E8 -3080000.0 -0.18 1.09580166E8 293000.0 0.02 -0.1116 -0.6312 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N01 mock treatment 1.16181533E8 8910000.0 0.51 1.10450981E8 1160000.0 0.07 0.411 0.7988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N02 mock treatment 1.09563924E8 2300000.0 0.13 1.12763548E8 3480000.0 0.21 0.2443 0.9723 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N03 compound treatment 1.03451189E8 -3820000.0 -0.22 1.03712999E8 -5570000.0 -0.34 -0.3972 -0.9759 2830 SPBio_002501 Clc1ccc2n(C3CCN(CCCn4c(=O)[nH]c5ccccc45)CC3)c(=O)[nH]c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N04 compound treatment 3.4284044E7 -7.3E7 -4.17 3.425341E7 -7.5E7 -4.63 -6.22 -0.9987 1309 SPBio_002502 Cc1cc(C2CCCCC2)n(O)c(=O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N05 compound treatment 1.02041883E8 -5230000.0 -0.3 9.5423847E7 -1.39E7 -0.85 -0.8154 -0.9008 3189434 SPBio_002503 Nc1nc(cs1)/C(=N\OCC(=O)O)/C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N06 compound treatment 9.8423857E7 -8840000.0 -0.51 9.6288676E7 -1.3E7 -0.8 -0.924 -0.9753 722 SPBio_002504 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N07 compound treatment 9.1016697E7 -1.63E7 -0.93 9.624902E7 -1.3E7 -0.8 -1.225 -0.9974 3069124 SPBio_002505 CN(C(=O)C)c1c(I)c(NC(=O)C)c(I)c(C(=O)NC2[C@H](O)OC(CO)[C@@H](O)[C@H]2O)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N08 compound treatment 9.4833766E7 -1.24E7 -0.71 9.9399142E7 -9890000.0 -0.61 -0.9335 -0.9971 1213 SPBio_002506 CNCCc1ccccn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N09 compound treatment 9.7114852E7 -1.02E7 -0.58 9.1753901E7 -1.75E7 -1.08 -1.1745 -0.9575 3189435 SPBio_002507 C[C@@H](O[C@@H]1[C@H](O)C(CO)O[C@H](O)C1NC(=O)C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N10 compound treatment 9.1549841E7 -1.57E7 -0.9 9.1433234E7 -1.79E7 -1.1 -1.4134 -0.9949 1000177 SPBio_002508 NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N11 compound treatment 8.435522E7 -2.29E7 -1.31 8.920085E7 -2.01E7 -1.24 -1.8014 -0.9996 2181 SPBio_002509 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3cc(O)c(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N12 compound treatment 9.6665178E7 -1.06E7 -0.61 1.01636105E8 -7650000.0 -0.47 -0.7619 -0.9923 1000096 SPBio_002510 C1CN2CC(N=C2S1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N13 compound treatment 9.3238388E7 -1.4E7 -0.8 9.4018543E7 -1.53E7 -0.94 -1.2325 -0.9968 1733214 SPBio_002511 Oc1ccc(cc1)C2CC(=O)c3c(O)cc(O)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N14 compound treatment 1.03636017E8 -3630000.0 -0.21 1.0029959E8 -8990000.0 -0.55 -0.5385 -0.9102 3068775 SPBio_002512 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N15 compound treatment 9.4599745E7 -1.27E7 -0.72 9.6213634E7 -1.31E7 -0.81 -1.0818 -0.9986 895 SPBio_002513 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N16 compound treatment 9.4102739E7 -1.32E7 -0.75 9.1889349E7 -1.74E7 -1.07 -1.2903 -0.985 1214 SPBio_002514 CCOC(=O)Nc1c[n+](no1)N2CCOCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N17 compound treatment 1.00325348E8 -6940000.0 -0.4 9.3999496E7 -1.53E7 -0.94 -0.9469 -0.9261 822 SPBio_002515 CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N18 compound treatment 9.1323113E7 -1.59E7 -0.91 9.1805368E7 -1.75E7 -1.08 -1.4063 -0.9965 1000114 SPBio_002516 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N19 compound treatment 9.5905754E7 -1.14E7 -0.65 8.9898306E7 -1.94E7 -1.2 -1.3043 -0.9589 1067495 SPBio_002517 [O-][N+](=O)c1cnc(s1)N2CCNC2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N20 compound treatment 1.03328254E8 -3940000.0 -0.23 1.05470957E8 -3820000.0 -0.24 -0.3255 -0.9998 1365793 SPBio_002518 COc1ccc(CN2CCNCC2)c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N21 compound treatment 1.02072129E8 -5190000.0 -0.3 9.5351648E7 -1.39E7 -0.86 -0.8174 -0.8993 3069161 SPBio_002519 NCc1ccccc1CC(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N22 compound treatment 2.877247E7 -7.85E7 -4.49 2.83533E7 -8.09E7 -4.99 -6.6999 -0.9986 3103826 SPBio_002520 C/C/1=C\CC[C@@]2(C)O[C@@H]2[C@H]3OC(=O)C(=C)[C@@H]3CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N23 mock treatment 9.73625E7 -9900000.0 -0.57 9.6938489E7 -1.23E7 -0.76 -0.9385 -0.9894 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 N24 mock treatment 1.05694645E8 -1570000.0 -0.09 1.076701E8 -1620000.0 -0.1 -0.134 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O01 mock treatment 1.13579688E8 6310000.0 0.36 1.22005199E8 1.27E7 0.78 0.8095 0.938 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O02 mock treatment 1.02794189E8 -4470000.0 -0.26 1.07573114E8 -1710000.0 -0.11 -0.2555 -0.9236 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O03 compound treatment 9.9526472E7 -7740000.0 -0.44 9.8691486E7 -1.06E7 -0.65 -0.7747 -0.982 3177204 SPBio_002521 CC(C(O)c1ccc(O)cc1)N2CCC(Cc3ccccc3)CC2.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O04 compound treatment 1.04967166E8 -2300000.0 -0.13 1.05675804E8 -3610000.0 -0.22 -0.2504 -0.9684 743 SPBio_002522 CC(C)(C)NCC(O)c1cc(O)cc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O05 compound treatment 1.00879219E8 -6390000.0 -0.37 9.8926043E7 -1.04E7 -0.64 -0.7098 -0.9648 43 SPBio_002523 Fc1ccc(cc1)C(N2CCN(C/C=C/c3ccccc3)CC2)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O06 compound treatment 1.05326418E8 -1940000.0 -0.11 1.01065668E8 -8220000.0 -0.51 -0.4368 -0.8419 3061431 SPBio_002524 OC(C(O)C(=O)O)C(=O)O.Fc1ccc(cc1)C(=O)C2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O07 compound treatment 6.3734425E7 -4.35E7 -2.49 6.1219577E7 -4.81E7 -2.96 -3.8544 -0.9962 437 SPBio_002525 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O08 compound treatment 9.4087428E7 -1.32E7 -0.75 9.6944239E7 -1.23E7 -0.76 -1.0706 -1.0 907335 SPBio_002526 C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)c3ccc(cc3)C4(O)C[N+](C)(C)CCO4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O09 compound treatment 9.2185421E7 -1.51E7 -0.86 9.3521138E7 -1.58E7 -0.97 -1.2967 -0.9982 3189181 SPBio_002527 CCOC(=O)[C@@H](CCc1ccccc1)NC(C)C(=O)N2CCC[C@@H]2C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O10 compound treatment 8.9436484E7 -1.78E7 -1.02 9.0596695E7 -1.87E7 -1.15 -1.5353 -0.9981 3471415 SPBio_002528 NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(O)C(O)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O11 compound treatment 9.0411084E7 -1.69E7 -0.96 9.0999373E7 -1.83E7 -1.13 -1.4783 -0.9969 1077 SPBio_002529 CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O12 compound treatment 1.0307826E8 -4190000.0 -0.24 1.07819218E8 -1470000.0 -0.09 -0.2333 -0.9115 3068923 SPBio_002530 NCC[C@H](O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC3OC(CO)C(O)C(N)C3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O13 compound treatment 1.0110192E8 -6170000.0 -0.35 9.6085629E7 -1.32E7 -0.81 -0.8246 -0.9298 74 SPBio_002531 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O14 compound treatment 3.0535214E7 -7.67E7 -4.39 3.0365191E7 -7.89E7 -4.86 -6.541 -0.9987 3189304 SPBio_002532 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O15 compound treatment 9.9330138E7 -7940000.0 -0.45 9.8087168E7 -1.12E7 -0.69 -0.8089 -0.9792 3055 SPBio_002533 NC(=N)NCCN1CCCCCCC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O16 compound treatment 1.0860748E8 1340000.0 0.08 1.07721297E8 -1570000.0 -0.1 -0.0141 -0.1143 3068926 SPBio_002534 CCN(CC)CCOc1ccc(cc1)/C(=C(/Cl)\c2ccccc2)/c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O17 compound treatment 3.6072096E7 -7.12E7 -4.07 3.0213761E7 -7.91E7 -4.87 -6.3238 -0.996 763 SPBio_002535 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O18 compound treatment 9.2979483E7 -1.43E7 -0.82 9.4979395E7 -1.43E7 -0.88 -1.201 -0.9993 3189305 SPBio_002536 CN1CCCN=C1/C=C/c2cccc(O)c2.OC(=O)c1cc2ccccc2c(Cc3cc4ccccc4c(C(=O)O)c3O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O19 compound treatment 8.1462551E7 -2.58E7 -1.47 7.479999E7 -3.45E7 -2.13 -2.546 -0.984 907228 SPBio_002537 CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O20 compound treatment 7.0602595E7 -3.67E7 -2.1 8.4552328E7 -2.47E7 -1.52 -2.5598 -0.9878 1041 SPBio_002538 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O21 compound treatment 7.9862776E7 -2.74E7 -1.57 8.9174653E7 -2.01E7 -1.24 -1.9841 -0.9933 1130 SPBio_002539 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O22 compound treatment 9.6417098E7 -1.08E7 -0.62 9.9205114E7 -1.01E7 -0.62 -0.8779 -1.0 3189306 SPBio_002540 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4OC(CO[C@@H]5OC(C)[C@H](O)[C@H](O)C5O)[C@@H](O)[C@@H](O)C4O)cc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O23 mock treatment 1.06821302E8 -446000.0 -0.03 1.00511042E8 -8780000.0 -0.54 -0.4006 -0.7396 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 O24 mock treatment 1.12410323E8 5140000.0 0.29 1.09398285E8 111000.0 0.01 0.2127 0.7234 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P01 mock treatment 1.19441017E8 1.22E7 0.7 1.21351377E8 1.21E7 0.74 1.0178 0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P02 mock treatment 1.14056292E8 6790000.0 0.39 1.2158644E8 1.23E7 0.76 0.8105 0.9516 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P03 compound treatment 2.9833127E7 -7.74E7 -4.43 2.9604466E7 -7.97E7 -4.91 -6.6025 -0.9986 1000325 SPBio_002541 C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P04 compound treatment 1.02811514E8 -4460000.0 -0.25 9.8193005E7 -1.11E7 -0.68 -0.6636 -0.9094 922 SPBio_002542 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P05 compound treatment 1.01222002E8 -6040000.0 -0.35 9.61773E7 -1.31E7 -0.81 -0.8157 -0.9281 3069162 SPBio_002543 CC(C)(CO)[C@H](O)C(=O)NCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P06 compound treatment 1.02367598E8 -4900000.0 -0.28 9.457841E7 -1.47E7 -0.91 -0.8391 -0.8843 2284 SPBio_002544 C[C@H](Cc1ccccc1)N(C)CC#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P07 compound treatment 1.02609166E8 -4660000.0 -0.27 9.6927736E7 -1.24E7 -0.76 -0.727 -0.9008 3189436 SPBio_002545 CO[C@]1(NC(=O)C2SC(=C(C(=O)N)C(=O)O)S2)[C@H]3SCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P08 compound treatment 8.9001669E7 -1.83E7 -1.04 8.8137858E7 -2.11E7 -1.3 -1.66 -0.9939 1020 SPBio_002546 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P09 compound treatment 9.889714E7 -8370000.0 -0.48 9.7819773E7 -1.15E7 -0.71 -0.8381 -0.9819 1534 SPBio_002547 O=C(/C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P10 compound treatment 9.4363444E7 -1.29E7 -0.74 9.3066858E7 -1.62E7 -1.0 -1.2285 -0.9888 196 SPBio_002548 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P11 compound treatment 9.1957164E7 -1.53E7 -0.87 9.1913952E7 -1.74E7 -1.07 -1.376 -0.995 1537011 SPBio_002549 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P12 compound treatment 7.0266662E7 -3.7E7 -2.11 6.9144623E7 -4.01E7 -2.47 -3.245 -0.9969 1931603 SPBio_002550 Oc1ccc(cc1)C(=O)N/N=C/c2ccc(o2)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P13 compound treatment 4.8740947E7 -5.85E7 -3.34 3.5225135E7 -7.41E7 -4.57 -5.5934 -0.9883 2551 SPBio_002551 COc1cc(NC(C)CCCN)c2ncccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P14 compound treatment 4.079483E7 -6.65E7 -3.8 4.0260853E7 -6.9E7 -4.25 -5.695 -0.9984 804 SPBio_002552 COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P15 compound treatment 1.00304038E8 -6960000.0 -0.4 9.6662715E7 -1.26E7 -0.78 -0.8317 -0.9515 1072 SPBio_002553 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P16 compound treatment 9.498997E7 -1.23E7 -0.7 9.2960251E7 -1.63E7 -1.01 -1.2078 -0.9844 3189565 SPBio_002554 CC[C@@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@@H](C)[C@@H]4N[C@H](COCCOC)OC([C@H]4C)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P17 compound treatment 9.7463007E7 -9800000.0 -0.56 9.1552134E7 -1.77E7 -1.09 -1.1692 -0.9518 3480329 SPBio_002555 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(Cl)c2Cl)C(=O)OC)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P18 compound treatment 9.4427718E7 -1.28E7 -0.73 9.8297464E7 -1.1E7 -0.68 -0.9979 -0.9992 3474312 SPBio_002556 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P19 compound treatment 9.0937862E7 -1.63E7 -0.93 9.8157484E7 -1.11E7 -0.69 -1.145 -0.9886 1362 SPBio_002557 COc1c2occc2cc3ccc(=O)oc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P20 compound treatment 8.9244905E7 -1.8E7 -1.03 9.6516897E7 -1.28E7 -0.79 -1.285 -0.9912 3060137 SPBio_002558 COc1ccccc1N2CCN(CCCCNC(=O)c3ccc4ccccc4c3)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P21 compound treatment 2.998136E7 -7.73E7 -4.42 2.9714792E7 -7.96E7 -4.91 -6.5917 -0.9986 3189437 SPBio_002559 COc1ccc(CC(N)C(=O)N[C@@H]2C(O)[C@@H](O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P22 compound treatment 6.3164686E7 -4.41E7 -2.52 7.274693E7 -3.65E7 -2.25 -3.375 -0.9984 1137095 SPBio_002560 CC(Cc1ccccc1)NCCC(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P23 mock treatment 1.10374311E8 3110000.0 0.18 1.06450662E8 -2840000.0 -0.17 0.0019 0.0077 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2165 P24 mock treatment 1.16439633E8 9170000.0 0.52 1.14199333E8 4910000.0 0.3 0.5848 0.966 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A01 mock treatment 1.28721641E8 1.75E7 1.0 1.27148652E8 2.09E7 1.29 1.6159 0.992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A02 mock treatment 1.16332197E8 5070000.0 0.29 1.15458621E8 9200000.0 0.57 0.6057 0.9513 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A03 compound treatment 1.14528325E8 3260000.0 0.19 1.15838576E8 9580000.0 0.59 0.5493 0.8872 3189566 SPBio_002561 COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7cccc(Oc(c1O)c32)c7)N(C)CCc6cc5OC)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A04 compound treatment 1.27088488E8 1.58E7 0.9 1.21279143E8 1.5E7 0.93 1.294 0.9999 3187611 SPBio_002562 COc1cc(ccc1c2nc3ncccc3[nH]2)S(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A05 compound treatment 1.00692682E8 -1.06E7 -0.6 1.05853811E8 -407000.0 -0.03 -0.445 -0.7358 907285 SPBio_002563 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@H]3[C@@H](Cc4c[nH]c5cccc3c45)N(C)C2)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A06 compound treatment 1.03346223E8 -7920000.0 -0.45 1.02076549E8 -4180000.0 -0.26 -0.5024 -0.9645 1254 SPBio_002564 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A07 compound treatment 1.08352058E8 -2910000.0 -0.17 1.06019943E8 -241000.0 -0.01 -0.1283 -0.7671 961 SPBio_002565 COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A08 compound treatment 3.7063946E7 -7.42E7 -4.24 3.5522545E7 -7.07E7 -4.36 -6.082 -0.9999 3187612 SPBio_002566 CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A09 compound treatment 9.2363163E7 -1.89E7 -1.08 1.02944677E8 -3320000.0 -0.2 -0.9084 -0.8262 3487467 SPBio_002567 CCOC(=O)Oc1c(OC)cc(cc1OC)C(=O)OC2CC3CN4CCc5c([nH]c6cc(OC)ccc56)C4CC3C(C2OC)C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A10 compound treatment 1.12470149E8 1200000.0 0.07 1.09873991E8 3610000.0 0.22 0.2062 0.8844 3069530 SPBio_002568 CC(=O)NC1CCSC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A11 compound treatment 1.02334946E8 -8930000.0 -0.51 1.00052582E8 -6210000.0 -0.38 -0.6315 -0.9899 1000124 SPBio_002569 CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A12 compound treatment 3.6674532E7 -7.46E7 -4.26 3.8350756E7 -6.79E7 -4.19 -5.9745 -1.0 1000240 SPBio_002570 CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A13 compound treatment 9.049036E7 -2.08E7 -1.19 9.3376581E7 -1.29E7 -0.79 -1.4012 -0.9809 976 SPBio_002571 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A14 compound treatment 5.2148853E7 -5.91E7 -3.38 6.2376649E7 -4.39E7 -2.71 -4.3019 -0.9939 3187613 SPBio_002572 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)OC2CC[C@]3(C=O)[C@H]4CC[C@]5(C)[C@H](CC[C@@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A15 compound treatment 9.9724964E7 -1.15E7 -0.66 1.03230994E8 -3030000.0 -0.19 -0.5985 -0.873 3189567 SPBio_002573 CCN1C[C@@]2(COC)C3[C@@H](OC)[C@H]4[C@@H]1[C@@]3(C5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)C5[C@]4(OC(=O)C)[C@@H](O)[C@H]6OC)[C@H](C[C@H]2O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A16 compound treatment 9.8077215E7 -1.32E7 -0.75 1.02876988E8 -3380000.0 -0.21 -0.6805 -0.8701 2060360 SPBio_002574 C1CN=C(C1)c2cccnc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A17 compound treatment 1.01609013E8 -9660000.0 -0.55 1.0253268E8 -3730000.0 -0.23 -0.5528 -0.9246 3141 SPBio_002575 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)/C=C/c6cc(OC)c(OC)c(OC)c6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A18 compound treatment 1.13600701E8 2330000.0 0.13 1.07338263E8 1080000.0 0.07 0.1413 0.9481 3069532 SPBio_002576 C[N+]1(C)C[C@@H](O)C[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A19 compound treatment 1.04408577E8 -6860000.0 -0.39 1.05347894E8 -913000.0 -0.06 -0.3169 -0.8004 3068781 SPBio_002577 CC(C)[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](Cc5c[nH]c6cccc4c56)N(C)C3)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A20 compound treatment 1.01675682E8 -9590000.0 -0.55 1.00122617E8 -6140000.0 -0.38 -0.6551 -0.9836 946 SPBio_002578 OCCNC(=O)Cn1ccnc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A21 compound treatment 3.6681404E7 -7.46E7 -4.26 3.9887515E7 -6.64E7 -4.09 -5.9072 -0.9998 3189569 SPBio_002579 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1CC4NCCc5cc(OC)c(OC)cc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A22 compound treatment 1.07851083E8 -3410000.0 -0.2 1.01237794E8 -5020000.0 -0.31 -0.3569 -0.9752 3187614 SPBio_002580 NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)[C@H](O)[C@@H]2N)[C@H](OC3O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A23 mock treatment 1.05050385E8 -6220000.0 -0.36 1.0402974E8 -2230000.0 -0.14 -0.3484 -0.9147 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 A24 mock treatment 1.17751141E8 6490000.0 0.37 1.17717588E8 1.15E7 0.71 0.7615 0.9547 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B01 mock treatment 1.31697869E8 2.04E7 1.17 1.26351636E8 2.01E7 1.24 1.7014 0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B02 mock treatment 1.08027158E8 -3240000.0 -0.19 1.04147015E8 -2110000.0 -0.13 -0.223 -0.9852 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B03 compound treatment 9.9969868E7 -1.13E7 -0.65 1.03630905E8 -2630000.0 -0.16 -0.5711 -0.858 1606 SPBio_002581 NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B04 compound treatment 9.448636E7 -1.68E7 -0.96 9.9260442E7 -7000000.0 -0.43 -0.9832 -0.935 1412 SPBio_002582 CN(C)CCOC(c1ccc(Cl)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B05 compound treatment 9.160698E7 -1.97E7 -1.12 1.0660901E8 348000.0 0.02 -0.7793 -0.6935 1524 SPBio_002583 CC(C)Nc1c(C)n(C)n(c2ccccc2)c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B06 compound treatment 1.03891827E8 -7370000.0 -0.42 9.9713727E7 -6550000.0 -0.4 -0.5834 -0.9998 3069629 SPBio_002584 CC(=O)/N=c/1\sc(nn1C)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B07 compound treatment 1.02809728E8 -8460000.0 -0.48 1.01050275E8 -5210000.0 -0.32 -0.5688 -0.9803 883 SPBio_002585 CC(Oc1ccccc1)C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B08 compound treatment 9.8944424E7 -1.23E7 -0.7 9.383701E7 -1.24E7 -0.77 -1.0395 -0.9991 818 SPBio_002586 CCC1(CC)C(=O)NC=CC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B09 compound treatment 8.8730912E7 -2.25E7 -1.29 9.4314907E7 -1.19E7 -0.74 -1.4314 -0.9648 887 SPBio_002587 COc1ccc(NS(=O)(=O)c2ccc(N)cc2)nn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B10 compound treatment 9.7557614E7 -1.37E7 -0.78 9.1407558E7 -1.49E7 -0.92 -1.2014 -0.997 795 SPBio_002588 CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B11 compound treatment 6.2908044E7 -4.84E7 -2.76 4.9856199E7 -5.64E7 -3.48 -4.4128 -0.9935 745 SPBio_002589 CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B12 compound treatment 1.03294659E8 -7970000.0 -0.46 9.3039169E7 -1.32E7 -0.82 -0.8984 -0.9622 1129 SPBio_002590 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B13 compound treatment 9.0238143E7 -2.1E7 -1.2 8.9660255E7 -1.66E7 -1.02 -1.5734 -0.9968 3263 SPBio_002591 CNC(C)(C)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B14 compound treatment 7.0617643E7 -4.06E7 -2.32 7.5816627E7 -3.04E7 -1.88 -2.9697 -0.9944 755 SPBio_002592 CC(CN(C)C)CN1c2ccccc2CCc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B15 compound treatment 1.05720258E8 -5550000.0 -0.32 9.2052404E7 -1.42E7 -0.88 -0.8434 -0.9055 3187750 SPBio_002593 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B16 compound treatment 8.2559455E7 -2.87E7 -1.64 4.7224052E7 -5.9E7 -3.64 -3.7334 -0.9352 1088922 SPBio_002594 CN(C)CCN(Cc1ccc(Cl)cc1)c2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B17 compound treatment 8.8842182E7 -2.24E7 -1.28 8.7476681E7 -1.88E7 -1.16 -1.725 -0.9987 751 SPBio_002595 COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B18 compound treatment 7.3491142E7 -3.78E7 -2.16 7.8912659E7 -2.73E7 -1.69 -2.7186 -0.9925 3043753 SPBio_002596 [O-][N+](=O)c1ccc(/C=N/N2CCOC2=O)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B19 compound treatment 9.2898788E7 -1.84E7 -1.05 9.2309157E7 -1.4E7 -0.86 -1.3504 -0.9951 1146 SPBio_002597 Nc1ccc(cc1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B20 compound treatment 1.08426802E8 -2840000.0 -0.16 1.03313519E8 -2950000.0 -0.18 -0.2432 -0.9984 2570 SPBio_002598 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B21 compound treatment 9.5609744E7 -1.57E7 -0.89 9.7284709E7 -8980000.0 -0.55 -1.024 -0.9733 3069577 SPBio_002599 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC(=O)[C@]23C)OC61CCC(C)CO6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B22 compound treatment 9.2773781E7 -1.85E7 -1.06 9.5023199E7 -1.12E7 -0.69 -1.2371 -0.979 871 SPBio_002600 Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B23 mock treatment 9.6753235E7 -1.45E7 -0.83 9.5962713E7 -1.03E7 -0.63 -1.0354 -0.9913 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 B24 mock treatment 1.07133548E8 -4130000.0 -0.24 1.12513855E8 6250000.0 0.39 0.1056 0.2335 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C01 mock treatment 1.17475326E8 6210000.0 0.35 1.13204688E8 6940000.0 0.43 0.5536 0.9957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C02 mock treatment 1.08885461E8 -2380000.0 -0.14 1.02587395E8 -3670000.0 -0.23 -0.2563 -0.9703 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C03 compound treatment 1.10669008E8 -597000.0 -0.03 1.08764176E8 2500000.0 0.15 0.085 0.5378 1218 SPBio_002601 CCCCNc1ccc(cc1)C(=O)OCCN(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C04 compound treatment 1.009127E8 -1.04E7 -0.59 1.05305303E8 -956000.0 -0.06 -0.46 -0.7737 1624 SPBio_002602 CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C05 compound treatment 3.2830281E7 -7.84E7 -4.48 3.1634804E7 -7.46E7 -4.6 -6.4226 -0.9999 1000293 SPBio_002603 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C06 compound treatment 1.02601618E8 -8660000.0 -0.5 1.03601172E8 -2660000.0 -0.16 -0.4661 -0.8935 3187615 SPBio_002604 CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)OC2[C@@]53C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C07 compound treatment 1.19491101E8 8230000.0 0.47 1.07958412E8 1700000.0 0.1 0.4064 0.8439 3189571 SPBio_002605 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]61CCC(C)CN6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C08 compound treatment 9.9369769E7 -1.19E7 -0.68 9.452051E7 -1.17E7 -0.72 -0.9925 -0.9995 1244 SPBio_002606 C[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C09 compound treatment 8.5462786E7 -2.58E7 -1.47 7.8066006E7 -2.82E7 -1.74 -2.2717 -0.9967 964 SPBio_002607 CN(C)N=Nc1[nH]cnc1C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C10 compound treatment 1.03327945E8 -7940000.0 -0.45 9.2487798E7 -1.38E7 -0.85 -0.9211 -0.9569 3187616 SPBio_002608 C/C(=C(\CCOP(=O)(O)O)/SC(=O)c1ccccc1)/N(Cc2cnc(C)nc2N)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C11 compound treatment 1.08646088E8 -2620000.0 -0.15 9.643749E7 -9820000.0 -0.61 -0.5341 -0.8562 3471597 SPBio_002609 CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C12 compound treatment 3.8146619E7 -7.31E7 -4.18 3.5601194E7 -7.07E7 -4.36 -6.0348 -0.9998 3069534 SPBio_002610 CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C13 compound treatment 1.04065075E8 -7200000.0 -0.41 9.6930312E7 -9330000.0 -0.58 -0.6977 -0.9865 1092107 SPBio_002611 CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C14 compound treatment 3.0036237E7 -8.12E7 -4.64 3.0316986E7 -7.59E7 -4.68 -6.5929 -1.0 3187617 SPBio_002612 CC1OC(C[C@@H](O)[C@@H]1OC2C[C@@H](O)[C@H](OC3C[C@@H](OC(=O)C)[C@H](OC4OC(CO)[C@@H](O)[C@@H](O)[C@@H]4O)C(C)O3)C(C)O2)OC5CC[C@@]6(C)[C@H](CC[C@@]7(C)[C@@]8(O)CC[C@H](C9=CC(=O)OC9)[C@@]8(C)[C@H](O)C[C@]67C)C5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C15 compound treatment 9.7218046E7 -1.4E7 -0.8 8.9787828E7 -1.65E7 -1.02 -1.2857 -0.9932 1000115 SPBio_002613 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C16 compound treatment 9.3611718E7 -1.77E7 -1.01 8.9163832E7 -1.71E7 -1.05 -1.4587 -0.9998 3103678 SPBio_002614 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)/NCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C17 compound treatment 9.570299E7 -1.56E7 -0.89 9.0287817E7 -1.6E7 -0.98 -1.3252 -0.9987 450 SPBio_002615 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C18 compound treatment 9.3964554E7 -1.73E7 -0.99 8.5788437E7 -2.05E7 -1.26 -1.5915 -0.9927 827 SPBio_002616 CCCCC1(COC(=O)CCC(=O)O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C19 compound treatment 8.7725315E7 -2.35E7 -1.35 8.8110982E7 -1.81E7 -1.12 -1.7424 -0.9958 1084508 SPBio_002617 COc1ccc2cc3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C20 compound treatment 8.3794556E7 -2.75E7 -1.57 8.5235506E7 -2.1E7 -1.3 -2.0266 -0.9955 3069535 SPBio_002618 C(Nc1ncnc2nc[nH]c12)c3ccco3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C21 compound treatment 9.607832E7 -1.52E7 -0.87 9.2478104E7 -1.38E7 -0.85 -1.2145 -0.9999 1219467 SPBio_002619 COc1cc2CCC(N)c3cc(=O)c(O)ccc3-c2c(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C22 compound treatment 9.8891543E7 -1.24E7 -0.71 9.5727328E7 -1.05E7 -0.65 -0.9592 -0.9991 3187618 SPBio_002620 CC[C@H](C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C/C=C(\C)/C(O[C@H]4C[C@H](OC)C(O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2)C=C[C@@H]1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C23 mock treatment 9.6393429E7 -1.49E7 -0.85 9.4997684E7 -1.13E7 -0.69 -1.092 -0.995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 C24 mock treatment 1.16721015E8 5460000.0 0.31 1.22231021E8 1.6E7 0.98 0.9166 0.8876 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D01 mock treatment 1.20326617E8 9060000.0 0.52 1.11266786E8 5010000.0 0.31 0.5844 0.9694 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D02 mock treatment 1.10682379E8 -583000.0 -0.03 1.11569698E8 5310000.0 0.33 0.2078 0.6318 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D03 compound treatment 1.21451764E8 1.02E7 0.58 1.07296704E8 1040000.0 0.06 0.4568 0.78 706 SPBio_002621 Nc1ccc(cc1)S(=O)(=O)Nc2cnc3ccccc3n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D04 compound treatment 1.17054625E8 5790000.0 0.33 1.05869137E8 -392000.0 -0.02 0.2169 0.6538 3472295 SPBio_002622 COc1c(O)cc2C(=O)OC3C(O)C(O)C(CO)OC3c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D05 compound treatment 1.15484168E8 4220000.0 0.24 1.05146235E8 -1110000.0 -0.07 0.1219 0.4862 3187751 SPBio_002623 CN(N=O)C(=O)NC1[C@@H](O)OC(CO)[C@@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D06 compound treatment 1.13626495E8 2360000.0 0.13 1.03626708E8 -2630000.0 -0.16 -0.0194 -0.092 1446 SPBio_002624 OC(COc1cccc2oc(cc(=O)c12)C(=O)O)COc3cccc4oc(cc(=O)c34)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D07 compound treatment 1.15731589E8 4470000.0 0.26 1.04781481E8 -1480000.0 -0.09 0.116 0.4279 3173081 SPBio_002625 COCCc1ccc(OCC(O)CNC(C)C)cc1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D08 compound treatment 1.07474827E8 -3790000.0 -0.22 9.9084894E7 -7180000.0 -0.44 -0.466 -0.9461 3187884 SPBio_002626 CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(=O)(O)O[C@@H]4C3OC(=O)CCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D09 compound treatment 3.3116888E7 -7.81E7 -4.47 3.1389589E7 -7.49E7 -4.62 -6.4217 -0.9999 3187752 SPBio_002627 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D10 compound treatment 1.05837979E8 -5430000.0 -0.31 9.3019997E7 -1.32E7 -0.82 -0.7965 -0.9122 3176931 SPBio_002628 NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S(=O)(=O)O)C3=O)C(=O)O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D11 compound treatment 1.09639081E8 -1630000.0 -0.09 9.7200761E7 -9060000.0 -0.56 -0.4607 -0.8136 359 SPBio_002629 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D12 compound treatment 1.05901371E8 -5360000.0 -0.31 9.4934851E7 -1.13E7 -0.7 -0.7105 -0.9317 717 SPBio_002630 OC(=O)c1ccccc1OP(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D13 compound treatment 1.07570445E8 -3700000.0 -0.21 9.7941274E7 -8320000.0 -0.51 -0.512 -0.9231 689 SPBio_002631 Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C(=O)O)s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D14 compound treatment 1.05711765E8 -5550000.0 -0.32 9.1658275E7 -1.46E7 -0.9 -0.8609 -0.902 1102 SPBio_002632 CC(C(=O)O)c1ccc(cc1)C(=O)c2cccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D15 compound treatment 1.02445874E8 -8820000.0 -0.5 9.1026564E7 -1.52E7 -0.94 -1.0205 -0.9574 3173859 SPBio_002633 CC(C)CC(=O)OC1C(O[C@@H]2C[C@H]([C@H]3CC[C@]4(CC5CC[C@H]4[C@]3(C)C2)[C@@H](O)C5=C)C(=O)O)OC(CO)C(OS(=O)(=O)O)C1OS(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D16 compound treatment 1.01941057E8 -9320000.0 -0.53 9.7783024E7 -8480000.0 -0.52 -0.7464 -1.0 1254 SPBio_002634 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D17 compound treatment 1.00528041E8 -1.07E7 -0.61 8.9945025E7 -1.63E7 -1.01 -1.1451 -0.9719 873 SPBio_002635 Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CNc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D18 compound treatment 1.08011605E8 -3250000.0 -0.19 9.3403675E7 -1.29E7 -0.79 -0.6919 -0.8499 1055 SPBio_002636 CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D19 compound treatment 1.01418013E8 -9850000.0 -0.56 9.2009386E7 -1.43E7 -0.88 -1.0192 -0.9768 1402956 SPBio_002637 CC(N)C(O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D20 compound treatment 1.03523766E8 -7740000.0 -0.44 9.0438548E7 -1.58E7 -0.98 -1.0025 -0.9361 1000139 SPBio_002638 CO[C@]1(NC(=O)C(C(=O)O)c2ccc(O)cc2)[C@H]3OCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D21 compound treatment 6.4810935E7 -4.65E7 -2.65 7.7754807E7 -2.85E7 -1.76 -3.1199 -0.9799 1531 SPBio_002639 O=c1n([se]c2ccccc12)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D22 compound treatment 1.05539698E8 -5730000.0 -0.33 9.7915377E7 -8350000.0 -0.51 -0.5952 -0.9762 856 SPBio_002640 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D23 mock treatment 9.3531616E7 -1.77E7 -1.01 9.2390687E7 -1.39E7 -0.85 -1.3213 -0.9964 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 D24 mock treatment 1.09875994E8 -1390000.0 -0.08 1.07512579E8 1250000.0 0.08 -0.0016 -0.0145 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E01 mock treatment 1.17670341E8 6400000.0 0.37 1.11208843E8 4950000.0 0.31 0.4745 0.9959 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E02 mock treatment 1.17602658E8 6340000.0 0.36 1.10632515E8 4370000.0 0.27 0.4466 0.9894 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E03 compound treatment 1.19184783E8 7920000.0 0.45 1.12445594E8 6180000.0 0.38 0.5896 0.9964 3180327 SPBio_002641 COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E04 compound treatment 1.16121907E8 4860000.0 0.28 1.1023274E8 3970000.0 0.24 0.3694 0.998 3069536 SPBio_002642 OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3c(=O)cc(oc23)c4ccc(O)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E05 compound treatment 1.15525765E8 4260000.0 0.24 1.05106275E8 -1150000.0 -0.07 0.1218 0.4803 1054667 SPBio_002643 CN1C(CC(O)c2ccccc2)CCCC1CC(O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E06 compound treatment 1.12029211E8 763000.0 0.04 9.9182988E7 -7080000.0 -0.44 -0.2777 -0.6332 1001945 SPBio_002644 CN1C[C@@]2(C=C)C3CC4OCC3C1[C@@H]2[C@@]45C(=O)Nc6ccccc65 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E07 compound treatment 9.9944113E7 -1.13E7 -0.65 9.0123359E7 -1.61E7 -0.99 -1.1609 -0.9783 959 SPBio_002645 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E08 compound treatment 1.01665489E8 -9600000.0 -0.55 9.1842653E7 -1.44E7 -0.89 -1.0164 -0.9731 3187619 SPBio_002646 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)OC61CCC(C)CN6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E09 compound treatment 1.07764331E8 -3500000.0 -0.2 9.7797614E7 -8460000.0 -0.52 -0.5104 -0.9134 3000363 SPBio_002647 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E10 compound treatment 1.04658731E8 -6610000.0 -0.38 9.4765495E7 -1.15E7 -0.71 -0.7681 -0.9566 3069538 SPBio_002648 CCN1C[C@]2(COC)CC[C@H](OC)[C@]3(C4C[C@H]5[C@H](OC)C4C6(C[C@@H]5OC)OCO[C@@]76[C@@H](O)C32)[C@@H]17 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E11 compound treatment 1.07498798E8 -3770000.0 -0.22 9.6271483E7 -9990000.0 -0.62 -0.5877 -0.9009 3061052 SPBio_002649 CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E12 compound treatment 1.01715589E8 -9550000.0 -0.55 9.2134858E7 -1.41E7 -0.87 -1.0017 -0.9747 1054504 SPBio_002650 COc1c(OCC(O)C(C)(C)O)ccc2c(OC)c3ccoc3nc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E13 compound treatment 9.7706482E7 -1.36E7 -0.77 9.4243568E7 -1.2E7 -0.74 -1.0718 -0.9997 909 SPBio_002651 COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E14 compound treatment 1.03432766E8 -7830000.0 -0.45 8.8776044E7 -1.75E7 -1.08 -1.0787 -0.9242 3187620 SPBio_002652 C[C@H]1CCC[C@@H](C)N1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E15 compound treatment 5.7785451E7 -5.35E7 -3.06 5.4351313E7 -5.19E7 -3.2 -4.4239 -0.9997 3189572 SPBio_002653 CN1Cc2c3OCOc3ccc2[C@H]4[C@@H](O)Cc5cc6OCOc6cc5[C@H]41 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E16 compound treatment 1.01336493E8 -9930000.0 -0.57 8.8876036E7 -1.74E7 -1.07 -1.159 -0.9558 1540789 SPBio_002654 COc1cc(=O)n(C)c2c(OCC(O)C(C)(C)O)cccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E17 compound treatment 1.0085907E8 -1.04E7 -0.59 8.9651683E7 -1.66E7 -1.02 -1.1445 -0.9666 1202 SPBio_002655 COc1ccc2CN(C)CC[C@]34C=C[C@H](O)C[C@@H]4Oc1c23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E18 compound treatment 9.9983278E7 -1.13E7 -0.64 8.727426E7 -1.9E7 -1.17 -1.2835 -0.9605 1054505 SPBio_002656 COc1ccc2c(OC)c3ccoc3nc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E19 compound treatment 9.6503762E7 -1.48E7 -0.84 8.9473938E7 -1.68E7 -1.03 -1.3283 -0.9949 1220 SPBio_002657 CN1CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E20 compound treatment 1.03328096E8 -7940000.0 -0.45 9.4642024E7 -1.16E7 -0.72 -0.8272 -0.9757 852250 SPBio_002658 C1CCC(NC1)c2cccnc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E21 compound treatment 1.00310391E8 -1.1E7 -0.63 9.0424321E7 -1.58E7 -0.98 -1.133 -0.977 3173993 SPBio_002659 O[C@H]1CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E22 compound treatment 6.553673E7 -4.57E7 -2.61 5.9803191E7 -4.65E7 -2.86 -3.873 -0.999 193 SPBio_002660 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E23 mock treatment 9.272331E7 -1.85E7 -1.06 8.8591937E7 -1.77E7 -1.09 -1.5195 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 E24 mock treatment 1.01610727E8 -9660000.0 -0.55 1.01726789E8 -4530000.0 -0.28 -0.5878 -0.9503 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F01 mock treatment 1.2038451E8 9120000.0 0.52 1.08852723E8 2590000.0 0.16 0.4815 0.8833 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F02 mock treatment 1.20415977E8 9150000.0 0.52 1.11891978E8 5630000.0 0.35 0.6152 0.9802 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F03 compound treatment 1.17772968E8 6510000.0 0.37 1.07086632E8 826000.0 0.05 0.299 0.7965 3069579 SPBio_002661 NC(=O)c1ccc[n+](c1)[C@H]2O[C@@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H](C(O)[C@H]3O)n4cnc5c(N)ncnc45)C(O)[C@H]2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F04 compound treatment 1.14345592E8 3080000.0 0.18 1.03702269E8 -2560000.0 -0.16 0.0129 0.0547 691 SPBio_002662 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2C1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F05 compound treatment 1.13212743E8 1950000.0 0.11 1.00181508E8 -6080000.0 -0.37 -0.1863 -0.4766 799 SPBio_002663 Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F06 compound treatment 1.08384804E8 -2880000.0 -0.16 9.8647031E7 -7610000.0 -0.47 -0.4483 -0.9013 1303 SPBio_002664 C[N+]1(CCC2CC1)CC2OC(=O)C(O)(c3ccccc3)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F07 compound treatment 7.100089E7 -4.03E7 -2.3 6.4404998E7 -4.19E7 -2.58 -3.4516 -0.9984 3187753 SPBio_002665 C[C@H]1C[C@H]2[C@@H]3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)CCC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F08 compound treatment 1.07707628E8 -3560000.0 -0.2 9.8362502E7 -7900000.0 -0.49 -0.4881 -0.925 1529 SPBio_002666 COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F09 compound treatment 1.03447254E8 -7820000.0 -0.45 9.5981728E7 -1.03E7 -0.63 -0.764 -0.9854 3187754 SPBio_002667 CNCC(O)C(O)C(O)C(O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F10 compound treatment 1.02590329E8 -8680000.0 -0.5 9.0953098E7 -1.53E7 -0.94 -1.0178 -0.9549 1114 SPBio_002668 NS(=O)(=O)c1cc2c(N=C(CSCc3ccccc3)NS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F11 compound treatment 1.04462224E8 -6800000.0 -0.39 9.2871671E7 -1.34E7 -0.83 -0.8586 -0.941 3187755 SPBio_002669 CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F12 compound treatment 9.8583833E7 -1.27E7 -0.72 8.8101411E7 -1.82E7 -1.12 -1.304 -0.9779 1000 SPBio_002670 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F13 compound treatment 9.8778067E7 -1.25E7 -0.71 8.8821182E7 -1.74E7 -1.08 -1.2648 -0.9802 3069580 SPBio_002671 C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F14 compound treatment 9.1464508E7 -1.98E7 -1.13 8.6845007E7 -1.94E7 -1.2 -1.6465 -0.9996 1052436 SPBio_002672 CCN(CC)CCc1nc(no1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F15 compound treatment 1.03326443E8 -7940000.0 -0.45 8.8687488E7 -1.76E7 -1.08 -1.0868 -0.9254 3069581 SPBio_002673 Cn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@H](O)c4ccccc4)C3=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F16 compound treatment 9.4507681E7 -1.68E7 -0.96 8.4804688E7 -2.15E7 -1.32 -1.6125 -0.9874 1397 SPBio_002674 CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F17 compound treatment 4.5990341E7 -6.53E7 -3.73 4.5803325E7 -6.05E7 -3.73 -5.2731 -1.0 3187756 SPBio_002675 CC[C@]1(CC[C@@H](O1)[C@]2(C)CC[C@]3(C[C@H](O)[C@@H](C)[C@H](O3)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O2)[C@@H]4O[C@H](C[C@@H]4C)[C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F18 compound treatment 6.1988765E7 -4.93E7 -2.82 5.8595285E7 -4.77E7 -2.94 -4.069 -0.9998 3187885 SPBio_002676 CC[C@H]([C@H]1O[C@@](CC)(C[C@@H]1C)[C@H]2CC[C@](O)(CC)[C@H](C)O2)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc3ccc(C)c(O)c3C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F19 compound treatment 9.89569E7 -1.23E7 -0.7 9.1009146E7 -1.53E7 -0.94 -1.1622 -0.9898 4338 SPBio_002677 CCC(NC(C)C)C(O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F20 compound treatment 9.9457097E7 -1.18E7 -0.67 9.4458813E7 -1.18E7 -0.73 -0.9916 -0.9993 1519 SPBio_002678 CC1(C)OC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F21 compound treatment 9.9615357E7 -1.17E7 -0.67 8.9509519E7 -1.68E7 -1.03 -1.201 -0.9775 3069582 SPBio_002679 C[C@@]1(O)CCOC(=O)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F22 compound treatment 8.1654836E7 -2.96E7 -1.69 7.5783399E7 -3.05E7 -1.88 -2.5251 -0.9986 852 SPBio_002680 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F23 mock treatment 9.8626109E7 -1.26E7 -0.72 8.821735E7 -1.8E7 -1.11 -1.2973 -0.9782 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 F24 mock treatment 9.684799E7 -1.44E7 -0.82 9.7100169E7 -9160000.0 -0.56 -0.982 -0.983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G01 mock treatment 1.22173192E8 1.09E7 0.62 1.11399785E8 5140000.0 0.32 0.6648 0.9507 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G02 mock treatment 1.20861365E8 9600000.0 0.55 1.10286567E8 4030000.0 0.25 0.5632 0.9357 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G03 compound treatment 1.19970014E8 8700000.0 0.5 1.09700069E8 3440000.0 0.21 0.5017 0.9277 1000946 SPBio_002681 COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G04 compound treatment 1.20081881E8 8820000.0 0.5 1.15206162E8 8950000.0 0.55 0.7462 0.999 3129 SPBio_002682 CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G05 compound treatment 1.13673784E8 2410000.0 0.14 1.06255246E8 -5670.0 0.0 0.0971 0.7053 3054974 SPBio_002683 COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G06 compound treatment 1.1099414E8 -272000.0 -0.02 1.03051474E8 -3210000.0 -0.2 -0.1509 -0.7603 1025381 SPBio_002684 COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G07 compound treatment 1.1307784E8 1810000.0 0.1 1.05172181E8 -1090000.0 -0.07 0.0258 0.2088 3189573 SPBio_002685 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)C3C[C@@H]21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G08 compound treatment 1.10290529E8 -975000.0 -0.06 1.00877106E8 -5380000.0 -0.33 -0.2741 -0.8145 3187622 SPBio_002686 CCN1C[C@]2(C)CC[C@H](OC)[C@@]34C2[C@H](OC(=O)C)C5(OCO[C@]65C[C@H](OC)C7C[C@]4(O)C6[C@H]7OC)[C@@H]13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G09 compound treatment 1.06163311E8 -5100000.0 -0.29 1.04374545E8 -1890000.0 -0.12 -0.2884 -0.9187 915 SPBio_002687 OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G10 compound treatment 1.07503416E8 -3760000.0 -0.22 9.9726133E7 -6530000.0 -0.4 -0.4369 -0.9568 1182082 SPBio_002688 Cn1c(cc(=O)c2ccccc12)c3ccc4OCOc4c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G11 compound treatment 1.04481045E8 -6780000.0 -0.39 9.8047503E7 -8210000.0 -0.51 -0.6322 -0.9913 1056553 SPBio_002689 CN1CCC23C4Nc5ccccc5C3(CCN4C)C1Nc6ccccc62 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G12 compound treatment 9.1698499E7 -1.96E7 -1.12 8.6589055E7 -1.97E7 -1.21 -1.6482 -0.9992 3069539 SPBio_002690 CN1CCC2=C[C@@H](O)[C@@H]3OC(=O)c4cc5OCOc5cc4C3[C@@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G13 compound treatment 1.05892789E8 -5370000.0 -0.31 1.01433201E8 -4830000.0 -0.3 -0.4276 -0.9999 3069519 SPBio_002691 COc1ccc(cc1OC)C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G14 compound treatment 9.488601E7 -1.64E7 -0.94 9.3114417E7 -1.31E7 -0.81 -1.235 -0.9974 3187623 SPBio_002692 CC=C(C)C(=O)OC1[C@H](OC(=O)C)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(OC6OC([C@H](O[C@H]7OC(CO)[C@H](O)[C@H](O)C7O)[C@H](O)C6O[C@H]8OC(CO)[C@H](O)[C@H](O)C8O)C(=O)O)[C@](C)(CO)C5CCC43C)C2CC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G15 compound treatment 1.03002769E8 -8260000.0 -0.47 9.1566767E7 -1.47E7 -0.91 -0.9744 -0.9539 2060325 SPBio_002693 COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(c34)-c2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G16 compound treatment 4.2474503E7 -6.88E7 -3.93 3.9719626E7 -6.65E7 -4.1 -5.6804 -0.9998 829 SPBio_002694 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G17 compound treatment 1.04825647E8 -6440000.0 -0.37 9.7046522E7 -9210000.0 -0.57 -0.6619 -0.9779 1076 SPBio_002695 Cc1cccc(C)c1NC2=NCCCS2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G18 compound treatment 1.02908758E8 -8360000.0 -0.48 9.7523033E7 -8740000.0 -0.54 -0.7186 -0.9982 1115322 SPBio_002696 COc1ccn(C)c(=O)c1C#N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G19 compound treatment 8.7185125E7 -2.41E7 -1.38 8.3048747E7 -2.32E7 -1.43 -1.9849 -0.9998 3179848 SPBio_002697 C/C=C\1/CC(=C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G20 compound treatment 1.03821187E8 -7440000.0 -0.43 9.8223668E7 -8040000.0 -0.5 -0.6512 -0.9971 3069540 SPBio_002698 CCN1C[C@]2(COC)CC[C@H](O)[C@]3(C4C[C@H]5C(OC)C4[C@](O)(C[C@H]5OC)C6(O)C(OC)C32)[C@H]16 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G21 compound treatment 1.02521681E8 -8740000.0 -0.5 9.3229519E7 -1.3E7 -0.8 -0.9214 -0.9739 1737132 SPBio_002699 COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c2c34)cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G22 compound treatment 1.09377803E8 -1890000.0 -0.11 9.9376193E7 -6880000.0 -0.42 -0.3764 -0.8595 3187624 SPBio_002700 C/C=C\1/C[N@@+]2(C)CCC34[C@@H]2C[C@@H]1C(=C4Nc5ccccc53)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G23 mock treatment 1.03434031E8 -7830000.0 -0.45 9.3216422E7 -1.3E7 -0.8 -0.8851 -0.9618 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 G24 mock treatment 1.04294369E8 -6970000.0 -0.4 1.04235606E8 -2030000.0 -0.12 -0.37 -0.8862 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H01 mock treatment 1.2476671E8 1.35E7 0.77 1.17433659E8 1.12E7 0.69 1.0326 0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H02 mock treatment 1.23307967E8 1.2E7 0.69 1.14133628E8 7870000.0 0.49 0.8298 0.9854 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H03 compound treatment 1.1140211E8 136000.0 0.01 1.16226721E8 9970000.0 0.61 0.4399 0.716 3480633 SPBio_002701 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H04 compound treatment 1.22315139E8 1.1E7 0.63 1.14784603E8 8520000.0 0.53 0.8181 0.9958 1452 SPBio_002702 CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H05 compound treatment 1.09863163E8 -1400000.0 -0.08 1.04924165E8 -1340000.0 -0.08 -0.1149 -0.9999 1404 SPBio_002703 Nc1ccc(N=Nc2ccccc2)c(N)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H06 compound treatment 1.11274692E8 8910.0 0.0 1.07742921E8 1480000.0 0.09 0.065 0.711 1189 SPBio_002704 CO[C@]1(NC(=O)Cc2cccs2)[C@H]3SCC(=C(N3C1=O)C(=O)O)COC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H07 compound treatment 1.10967615E8 -298000.0 -0.02 1.04724516E8 -1540000.0 -0.09 -0.079 -0.8212 1451 SPBio_002705 CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H08 compound treatment 1.05247805E8 -6020000.0 -0.34 9.668266E7 -9580000.0 -0.59 -0.6607 -0.9669 1000080 SPBio_002706 ClCCNP1(=O)OCCCN1CCCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H09 compound treatment 1.05396769E8 -5870000.0 -0.34 1.01911211E8 -4350000.0 -0.27 -0.4268 -0.9938 1438 SPBio_002707 CC(C(=O)O)c1cccc(Oc2ccccc2)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H10 compound treatment 1.05945551E8 -5320000.0 -0.3 1.00467512E8 -5790000.0 -0.36 -0.4675 -0.9968 3187886 SPBio_002708 CO[C@@H]1[C@H](OC(=O)N)C(O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H11 compound treatment 1.01984074E8 -9280000.0 -0.53 9.6581935E7 -9680000.0 -0.6 -0.797 -0.9983 963 SPBio_002709 CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4)C(=O)C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H12 compound treatment 9.105138E7 -2.02E7 -1.16 8.7675652E7 -1.86E7 -1.15 -1.627 -1.0 1232 SPBio_002710 OC1=C(O)C(=O)C(=C(O)C1=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H13 compound treatment 9.0693637E7 -2.06E7 -1.18 9.2711977E7 -1.35E7 -0.84 -1.4219 -0.986 1138 SPBio_002711 CC/C(=C(/CC)\c1ccc(O)cc1)/c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H14 compound treatment 9.8270992E7 -1.3E7 -0.74 9.4982981E7 -1.13E7 -0.7 -1.0167 -0.9995 1029 SPBio_002712 CC(C(=O)O)c1ccc(cc1)N2Cc3ccccc3C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H15 compound treatment 9.8050599E7 -1.32E7 -0.76 9.2611468E7 -1.36E7 -0.84 -1.129 -0.9985 3057880 SPBio_002713 COc1ccc(cc1)C(=C(c2ccc(OC)cc2)c3ccc(OC)cc3)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H16 compound treatment 9.1833104E7 -1.94E7 -1.11 9.4846938E7 -1.14E7 -0.7 -1.2828 -0.9757 1276 SPBio_002714 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H17 compound treatment 9.948092E7 -1.18E7 -0.67 7.5722709E7 -3.05E7 -1.88 -1.8073 -0.904 3187757 SPBio_002715 NCC1OC(OC2C(N)CC(N)C(O)C2O[C@@H]3O[C@H](CO)[C@H](O)C3O)C(N)C(O)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H18 compound treatment 9.4156058E7 -1.71E7 -0.98 8.5570654E7 -2.07E7 -1.28 -1.5933 -0.9914 3187887 SPBio_002716 CC(CN(C(=O)C)c1c(I)cc(I)c(N)c1I)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H19 compound treatment 1.00388217E8 -1.09E7 -0.62 9.3216124E7 -1.3E7 -0.8 -1.0082 -0.9919 1094620 SPBio_002717 CC(C[N+](C)(C)C)OC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H20 compound treatment 9.7456328E7 -1.38E7 -0.79 9.3002246E7 -1.33E7 -0.82 -1.136 -0.9998 1670 SPBio_002718 Nc1nc2n(COC(CO)CO)cnc2c(=O)[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H21 compound treatment 1.0214146E8 -9120000.0 -0.52 8.9524208E7 -1.67E7 -1.03 -1.0983 -0.95 1246 SPBio_002719 CC[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H22 compound treatment 9.4261777E7 -1.7E7 -0.97 8.4015718E7 -2.22E7 -1.37 -1.6568 -0.9858 727 SPBio_002720 CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H23 mock treatment 9.6127194E7 -1.51E7 -0.87 9.1141771E7 -1.51E7 -0.93 -1.2708 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 H24 mock treatment 1.11422568E8 157000.0 0.01 1.0296256E8 -3300000.0 -0.2 -0.1374 -0.6753 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I01 mock treatment 1.28658107E8 1.74E7 0.99 1.15693849E8 9430000.0 0.58 1.114 0.9674 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I02 mock treatment 1.25880161E8 1.46E7 0.84 1.1822207E8 1.2E7 0.74 1.112 0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I03 compound treatment 5.5509079E7 -5.58E7 -3.19 5.2435158E7 -5.38E7 -3.32 -4.5994 -0.9998 3069520 SPBio_002721 COc1ccc2CC3N(CCc4cc(OC)c(O)cc34)Cc2c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I04 compound treatment 1.17883547E8 6620000.0 0.38 1.12370613E8 6110000.0 0.38 0.5337 1.0 3069541 SPBio_002722 C[C@H]1[C@H]2[C@H](OC1=O)[C@H]3C(=CC(=O)C3=C(C)C[C@@H]2O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I05 compound treatment 1.17113273E8 5850000.0 0.33 1.13263612E8 7000000.0 0.43 0.5415 0.992 3069521 SPBio_002723 CCC1[C@@H](O)N2C3C[C@@]45[C@H](O)C3C1CC2[C@@H]5N(C)c6ccccc64 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I06 compound treatment 1.1202788E8 762000.0 0.04 1.07620143E8 1360000.0 0.08 0.09 0.9535 3187625 SPBio_002724 CC[N+]1(C)C2CCC1CC(C2)OC(=O)[C@H]3CCC(C(=O)OC4CC5CCC(C4)[N+]5(C)CC)(c6ccccc6)c7ccccc37 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I07 compound treatment 8.0423883E7 -3.08E7 -1.76 7.8741894E7 -2.75E7 -1.7 -2.4459 -0.9998 1539 SPBio_002725 C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)[C@H]23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I08 compound treatment 1.10536888E8 -729000.0 -0.04 1.04885981E8 -1370000.0 -0.08 -0.0894 -0.9465 3173628 SPBio_002726 CN1C(C)(C)CCCC1(C)C.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I09 compound treatment 2.8279762E7 -8.3E7 -4.74 2.761033E7 -7.87E7 -4.85 -6.7819 -0.9999 3069522 SPBio_002727 COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I10 compound treatment 9.8186142E7 -1.31E7 -0.75 9.5313463E7 -1.09E7 -0.67 -1.0058 -0.9987 3069542 SPBio_002728 COC(C)C(O)(C(C)C)C(=O)OCC1=CCN2CC[C@H](O)[C@H]21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I11 compound treatment 1.06560358E8 -4710000.0 -0.27 9.9710195E7 -6550000.0 -0.4 -0.4757 -0.9805 3100 SPBio_002729 COc1c2OCOc2cc3CCN(C)Cc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I12 compound treatment 9.6217187E7 -1.5E7 -0.86 9.2635894E7 -1.36E7 -0.84 -1.202 -0.9999 3487155 SPBio_002730 C1CNC2C(C1)C3CCC2C4N3CCc5c4[nH]c6ccccc56 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I13 compound treatment 9.9827893E7 -1.14E7 -0.65 9.5882177E7 -1.04E7 -0.64 -0.9146 -0.9999 3189574 SPBio_002731 O[C@H]([C@@H]1CC2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I14 compound treatment 3.8447705E7 -7.28E7 -4.16 3.783259E7 -6.84E7 -4.22 -5.9254 -1.0 3069543 SPBio_002732 O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@@H](C32)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I15 compound treatment 5.86351E7 -5.26E7 -3.01 5.8323737E7 -4.79E7 -2.95 -4.2164 -1.0 1039 SPBio_002733 CC[C@]1(CCCN2CCc3c4[C@@H]21)CC(=O)n4c5ccccc35 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I16 compound treatment 9.9405597E7 -1.19E7 -0.68 9.3067929E7 -1.32E7 -0.81 -1.0544 -0.9959 3187744 SPBio_002734 CCN1C[C@]2(C)CC[C@H](O)C3(C4C[C@H]5C(O)C4[C@](O)(C[C@@H]5OC)C6CC32)[C@H]61 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I17 compound treatment 9.9772393E7 -1.15E7 -0.66 9.9128887E7 -7130000.0 -0.44 -0.7753 -0.9809 3069523 SPBio_002735 O[C@@H]([C@H]1CC2CCN1C[C@H]2C=C)c3ccnc4ccccc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I18 compound treatment 1.02939485E8 -8330000.0 -0.48 9.7662418E7 -8600000.0 -0.53 -0.7113 -0.9986 3187745 SPBio_002736 C[C@@]12CC[C@H]3[C@@H](CCc4cc(OS(=O)(=O)O)ccc34)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I19 compound treatment 1.04539376E8 -6730000.0 -0.38 9.6991316E7 -9270000.0 -0.57 -0.6759 -0.9814 3189575 SPBio_002737 N[C@H](CCONC(=N)N)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I20 compound treatment 1.01202781E8 -1.01E7 -0.58 9.6151959E7 -1.01E7 -0.62 -0.8473 -0.9992 3069544 SPBio_002738 CO[C@@H]1C=C2CCN(C)[C@@H]2C3[C@H]1OC(=O)c4cc5OCOc5cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I21 compound treatment 1.00520106E8 -1.07E7 -0.61 9.5357807E7 -1.09E7 -0.67 -0.9095 -0.999 1530 SPBio_002739 COc1ccc2c3CCN=C(C)c3[nH]c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I22 compound treatment 9.6610105E7 -1.47E7 -0.84 9.1685895E7 -1.46E7 -0.9 -1.2276 -0.9994 3187746 SPBio_002740 CCN1C[C@]2(C)CC[C@H](O)C3(C2CC4[C@H]13)C5C[C@H](O)C6C[C@]45[C@H](O)C6=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I23 mock treatment 1.07166295E8 -4100000.0 -0.23 9.6949287E7 -9310000.0 -0.57 -0.5715 -0.9219 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 I24 mock treatment 1.11179549E8 -86200.0 0.0 1.09452416E8 3190000.0 0.2 0.1356 0.6892 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J01 mock treatment 1.28095426E8 1.68E7 0.96 1.17218978E8 1.1E7 0.68 1.1578 0.985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J02 mock treatment 1.21174579E8 9910000.0 0.57 1.18048888E8 1.18E7 0.73 0.9142 0.9924 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J03 compound treatment 1.19703541E8 8440000.0 0.48 1.11456366E8 5200000.0 0.32 0.5674 0.9802 1429 SPBio_002741 CCCCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J04 compound treatment 8.2161433E7 -2.91E7 -1.66 7.9414041E7 -2.68E7 -1.65 -2.3464 -1.0 3187888 SPBio_002742 O=C1OC2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J05 compound treatment 1.12586858E8 1320000.0 0.08 1.09419048E8 3160000.0 0.19 0.191 0.9149 867 SPBio_002743 Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J06 compound treatment 1.03007396E8 -8260000.0 -0.47 1.00768521E8 -5490000.0 -0.34 -0.5731 -0.9867 3044756 SPBio_002744 CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J07 compound treatment 1.05304496E8 -5960000.0 -0.34 1.0264844E8 -3610000.0 -0.22 -0.3984 -0.9788 1001 SPBio_002745 CN(C)CCOC(=O)COc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J08 compound treatment 1.07574029E8 -3690000.0 -0.21 1.04142142E8 -2120000.0 -0.13 -0.2415 -0.9734 3187889 SPBio_002746 CCOc1ccc2ccccc2c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J09 compound treatment 1.03152631E8 -8110000.0 -0.46 1.02397027E8 -3860000.0 -0.24 -0.4963 -0.9521 3069584 SPBio_002747 [O-][N+](=O)c1ccc(/C=N/N2CC(CN3CCOCC3)OC2=O)o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J10 compound treatment 1.02834489E8 -8430000.0 -0.48 9.687313E7 -9390000.0 -0.58 -0.7499 -0.9959 1057 SPBio_002748 OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J11 compound treatment 9.2359004E7 -1.89E7 -1.08 9.1150003E7 -1.51E7 -0.93 -1.4227 -0.9973 837 SPBio_002749 CCOc1ccc2NC(C)(C)C=C(C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J12 compound treatment 9.5115487E7 -1.62E7 -0.92 9.6559605E7 -9700000.0 -0.6 -1.0755 -0.9779 3069693 SPBio_002750 CN(C)CCCO[C@H]1[C@H](OC2OC(C)(C)O[C@@H]12)C(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J13 compound treatment 9.3706409E7 -1.76E7 -1.0 9.2187467E7 -1.41E7 -0.87 -1.323 -0.9974 2575 SPBio_002751 CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J14 compound treatment 9.0419692E7 -2.08E7 -1.19 9.0280564E7 -1.6E7 -0.99 -1.539 -0.9955 2710 SPBio_002752 COc1ccc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(O)C#C)[C@@H]3CCc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J15 compound treatment 9.6969489E7 -1.43E7 -0.82 9.5390749E7 -1.09E7 -0.67 -1.0516 -0.9952 3187758 SPBio_002753 NC(=N)NCC1COC2(CCCCC2)O1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J16 compound treatment 8.5898853E7 -2.54E7 -1.45 9.2199012E7 -1.41E7 -0.87 -1.6381 -0.9698 3452 SPBio_002754 CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J17 compound treatment 8.866323E7 -2.26E7 -1.29 8.5428682E7 -2.08E7 -1.28 -1.8215 -1.0 3060003 SPBio_002755 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](O)C3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J18 compound treatment 9.3454445E7 -1.78E7 -1.02 9.3662699E7 -1.26E7 -0.78 -1.2689 -0.9911 3487254 SPBio_002756 CC(=O)N(CC(O)CN(C(=O)C)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c2c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c2I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J19 compound treatment 9.4386393E7 -1.69E7 -0.96 9.4050393E7 -1.22E7 -0.75 -1.2144 -0.9925 1094 SPBio_002757 COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J20 compound treatment 1.01677564E8 -9590000.0 -0.55 9.4095918E7 -1.22E7 -0.75 -0.9177 -0.9881 3069696 SPBio_002758 CN(C)[C@H]1C2CC3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCN4CCCC4)C(=O)c5c(O)cccc5[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J21 compound treatment 9.9337029E7 -1.19E7 -0.68 9.1908569E7 -1.44E7 -0.88 -1.1077 -0.9917 888 SPBio_002759 CC(C)[N+](C)(CCC(C(=O)N)(c1ccccc1)c2ccccc2)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J22 compound treatment 9.7588828E7 -1.37E7 -0.78 8.6432121E7 -1.98E7 -1.22 -1.417 -0.9767 1405 SPBio_002760 C[C@@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J23 mock treatment 1.1497084E8 3710000.0 0.21 1.08422567E8 2160000.0 0.13 0.244 0.9751 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 J24 mock treatment 1.00289741E8 -1.1E7 -0.63 1.06054321E8 -207000.0 -0.01 -0.4526 -0.7213 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K01 mock treatment 1.20288718E8 9020000.0 0.52 1.11005688E8 4740000.0 0.29 0.5715 0.9639 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K02 mock treatment 1.13444729E8 2180000.0 0.12 1.04880974E8 -1380000.0 -0.09 0.0279 0.185 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K03 compound treatment 1.16975763E8 5710000.0 0.33 1.07775316E8 1510000.0 0.09 0.2968 0.8743 1578 SPBio_002761 CC1=NCCc2c1[nH]c3cc(O)ccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K04 compound treatment 1.20552974E8 9290000.0 0.53 1.15144394E8 8880000.0 0.55 0.7625 0.9999 3187747 SPBio_002762 COc1cc(ccc1O)C(=O)OC2CC3CCC(C2)N3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K05 compound treatment 8.392897E7 -2.73E7 -1.56 8.3567444E7 -2.27E7 -1.4 -2.0939 -0.9985 1043296 SPBio_002763 Cc1nccc2c3ccc(O)cc3[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K06 compound treatment 1.05395361E8 -5870000.0 -0.34 1.01375947E8 -4880000.0 -0.3 -0.4502 -0.9985 3187748 SPBio_002764 CC(=O)O[C@H]1C2[C@]3([C@H]4[C@@H]5[C@@H](O)[C@@H]1C(=C)CC52CC6C37)[C@H](OC(=O)C)[C@H](C[C@@]7(C)CN46)OC(=O)c8ccccc8 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K07 compound treatment 8.7242129E7 -2.4E7 -1.37 8.4329233E7 -2.19E7 -1.35 -1.9268 -1.0 297849 SPBio_002765 COc1ccc2c(c1)[nH]c3c(C)nccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K08 compound treatment 9.4594169E7 -1.67E7 -0.95 9.6610837E7 -9650000.0 -0.59 -1.0944 -0.9743 1047 SPBio_002766 CN(C)CCCN1c2ccccc2Sc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K09 compound treatment 2.851424E7 -8.28E7 -4.73 2.7746552E7 -7.85E7 -4.84 -6.7665 -0.9999 2057 SPBio_002767 Cc1c2[nH]c3ccccc3c2c(C)c4cnccc14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K10 compound treatment 9.5408778E7 -1.59E7 -0.91 9.4753696E7 -1.15E7 -0.71 -1.1424 -0.9927 1177 SPBio_002768 Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K11 compound treatment 2.9048069E7 -8.22E7 -4.7 2.8672439E7 -7.76E7 -4.78 -6.7045 -1.0 3069524 SPBio_002769 O=C1C=CC(=O)c2c1ccc3c2ccc4ccccc43 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K12 compound treatment 8.5316507E7 -2.59E7 -1.48 8.4327795E7 -2.19E7 -1.35 -2.0047 -0.9989 1463 SPBio_002770 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K13 compound treatment 8.9514495E7 -2.18E7 -1.24 8.836027E7 -1.79E7 -1.1 -1.6593 -0.9982 3189576 SPBio_002771 CN(CCCCCCCCCCN(C)C(=O)Oc1ccccc1[N+](C)(C)C)C(=O)Oc2ccccc2[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K14 compound treatment 9.5936601E7 -1.53E7 -0.88 9.6446154E7 -9810000.0 -0.61 -1.0473 -0.9837 1424515 SPBio_002772 CCN1C(=O)NC(C1=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K15 compound treatment 8.9339755E7 -2.19E7 -1.25 9.1717511E7 -1.45E7 -0.9 -1.52 -0.9865 1494 SPBio_002773 C1CN(CCN1)c2ccc3ccccc3n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K16 compound treatment 8.5133036E7 -2.61E7 -1.49 8.3004189E7 -2.33E7 -1.43 -2.0698 -0.9998 3069570 SPBio_002774 C[C@@]12CCC3[C@@H](CC[C@@H]4C[C@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K17 compound treatment 9.2158478E7 -1.91E7 -1.09 8.9096747E7 -1.72E7 -1.06 -1.5203 -0.9999 3069525 SPBio_002775 C1CCN2C[C@@H]3C[C@H](CN4CCCC[C@H]34)[C@@H]2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K18 compound treatment 9.5822947E7 -1.54E7 -0.88 8.9816541E7 -1.64E7 -1.01 -1.3409 -0.9976 1444 SPBio_002776 C1CN=C(N1)C2CCCc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K19 compound treatment 4.8640925E7 -6.26E7 -3.58 4.575468E7 -6.05E7 -3.73 -5.1682 -0.9998 3043 SPBio_002777 C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)C)C(=O)COC(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K20 compound treatment 1.01019388E8 -1.02E7 -0.59 8.9837341E7 -1.64E7 -1.01 -1.1299 -0.9661 1070 SPBio_002778 CCC(C(CC)c1ccc(O)cc1)c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K21 compound treatment 1.02180589E8 -9090000.0 -0.52 9.3290795E7 -1.3E7 -0.8 -0.9325 -0.9782 1035065 SPBio_002779 Cc1nccc2c3ccccc3[nH]c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K22 compound treatment 9.6779246E7 -1.45E7 -0.83 8.6555567E7 -1.97E7 -1.21 -1.4443 -0.9825 1000312 SPBio_002780 CO[C@]1(NC(=O)CSCC#N)[C@H]2SCC(=C(N2C1=O)C(=O)O)CSc3nnnn3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K23 mock treatment 9.8462275E7 -1.28E7 -0.73 9.0912537E7 -1.53E7 -0.95 -1.1864 -0.9919 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 K24 mock treatment 1.01498368E8 -9770000.0 -0.56 1.00630382E8 -5630000.0 -0.35 -0.6401 -0.9739 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L01 mock treatment 1.21376878E8 1.01E7 0.58 1.12215475E8 5950000.0 0.37 0.6682 0.976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L02 mock treatment 1.04614719E8 -6650000.0 -0.38 1.00107321E8 -6150000.0 -0.38 -0.537 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L03 compound treatment 3.7019268E7 -7.42E7 -4.24 3.5861104E7 -7.04E7 -4.34 -6.069 -0.9999 3187759 SPBio_002781 CCC(=O)OCC(=O)C1(OC(=O)CC)[C@H](C)C[C@H]2[C@@H]3[C@H](Cl)CC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L04 compound treatment 1.08237745E8 -3030000.0 -0.17 1.03447472E8 -2810000.0 -0.17 -0.245 -1.0 712 SPBio_002782 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSc3ccncc3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L05 compound treatment 1.01102768E8 -1.02E7 -0.58 9.889723E7 -7360000.0 -0.45 -0.7317 -0.9926 1499 SPBio_002783 Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L06 compound treatment 1.07339081E8 -3930000.0 -0.22 1.04284905E8 -1980000.0 -0.12 -0.2448 -0.9588 3187892 SPBio_002784 C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)C3(O)C(=C2C(=O)c4c(O)cccc14)O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L07 compound treatment 9.3926252E7 -1.73E7 -0.99 9.1875937E7 -1.44E7 -0.89 -1.3277 -0.9985 3069624 SPBio_002785 CC[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L08 compound treatment 1.07199787E8 -4070000.0 -0.23 9.8984691E7 -7280000.0 -0.45 -0.4815 -0.9531 1000323 SPBio_002786 N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L09 compound treatment 3.7233388E7 -7.4E7 -4.23 3.7570094E7 -6.87E7 -4.23 -5.9859 -1.0 3187760 SPBio_002787 CC(=O)OCC(=O)[C@]12OC(C)(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]31C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L10 compound treatment 9.6614586E7 -1.47E7 -0.84 9.9237127E7 -7020000.0 -0.43 -0.8982 -0.9529 3187893 SPBio_002788 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC3OC(C)CC(C3O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L11 compound treatment 9.4604857E7 -1.67E7 -0.95 9.1762592E7 -1.45E7 -0.89 -1.3053 -0.9995 934 SPBio_002789 Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L12 compound treatment 3.6365643E7 -7.49E7 -4.28 3.6008707E7 -7.03E7 -4.33 -6.089 -1.0 1000270 SPBio_002790 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L13 compound treatment 8.8409529E7 -2.29E7 -1.31 8.5793016E7 -2.05E7 -1.26 -1.8158 -0.9998 896 SPBio_002791 COc1ccccc1OCC(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L14 compound treatment 8.4513952E7 -2.68E7 -1.53 8.6579884E7 -1.97E7 -1.21 -1.939 -0.9934 865 SPBio_002792 Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L15 compound treatment 3.3855446E7 -7.74E7 -4.42 3.4745643E7 -7.15E7 -4.41 -6.2455 -1.0 1324 SPBio_002793 CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L16 compound treatment 8.2485612E7 -2.88E7 -1.64 8.5672019E7 -2.06E7 -1.27 -2.0605 -0.9918 3069698 SPBio_002794 CC(C)(C)NC[C@@H](O)COc1cccc2C(=O)CCCc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L17 compound treatment 8.8916007E7 -2.23E7 -1.28 8.397606E7 -2.23E7 -1.37 -1.8746 -0.9993 1338 SPBio_002795 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L18 compound treatment 8.93002E7 -2.2E7 -1.26 8.735112E7 -1.89E7 -1.17 -1.7119 -0.9993 1215118 SPBio_002796 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L19 compound treatment 9.5388897E7 -1.59E7 -0.91 9.3646389E7 -1.26E7 -0.78 -1.1915 -0.997 1533 SPBio_002797 Cc1cc(CC(=O)O)n(C)c1C(=O)c2ccc(Cl)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L20 compound treatment 8.3584045E7 -2.77E7 -1.58 8.0242003E7 -2.6E7 -1.6 -2.2528 -1.0 1736 SPBio_002798 CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c(c2ccc(F)cc2)c3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L21 compound treatment 9.8971812E7 -1.23E7 -0.7 9.1013523E7 -1.52E7 -0.94 -1.1614 -0.9897 956 SPBio_002799 CCn1nc(C(=O)O)c(=O)c2cc3OCOc3cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L22 compound treatment 9.3138361E7 -1.81E7 -1.04 8.5813818E7 -2.04E7 -1.26 -1.6238 -0.9953 3069699 SPBio_002800 C[C@@H]1NC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L23 mock treatment 9.934839E7 -1.19E7 -0.68 8.9309878E7 -1.7E7 -1.04 -1.2205 -0.9785 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 L24 mock treatment 1.03808893E8 -7460000.0 -0.43 1.04611787E8 -1650000.0 -0.1 -0.3732 -0.8519 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M01 mock treatment 1.27376089E8 1.61E7 0.92 1.22878391E8 1.66E7 1.02 1.3754 0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M02 mock treatment 1.1595819E8 4690000.0 0.27 1.1121842E8 4960000.0 0.31 0.4057 0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M03 compound treatment 1.14528178E8 3260000.0 0.19 1.05243427E8 -1020000.0 -0.06 0.0875 0.4448 1048750 SPBio_002801 COc1ccc2[nH]c3C(=NCCc3c2c1)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M04 compound treatment 1.07937826E8 -3330000.0 -0.19 9.9530309E7 -6730000.0 -0.41 -0.4279 -0.9375 1005 SPBio_002802 OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M05 compound treatment 1.00078942E8 -1.12E7 -0.64 9.5944326E7 -1.03E7 -0.64 -0.9018 -1.0 3069526 SPBio_002803 C[N+]1(C)CCC[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M06 compound treatment 9.8573098E7 -1.27E7 -0.73 9.5682658E7 -1.06E7 -0.65 -0.974 -0.9986 1603 SPBio_002804 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M07 compound treatment 9.9821168E7 -1.14E7 -0.65 9.4010591E7 -1.23E7 -0.76 -0.9965 -0.9974 2709 SPBio_002805 Cc1ncc(CO)c(CO)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M08 compound treatment 1.14029644E8 2760000.0 0.16 1.10748042E8 4490000.0 0.28 0.3073 0.9647 907320 SPBio_002806 CC(C)c1c(CN(C)C(C)Cc2ccccc2)n(C)n(c3ccccc3)c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M09 compound treatment 9.8503483E7 -1.28E7 -0.73 9.5844282E7 -1.04E7 -0.64 -0.9698 -0.998 3189578 SPBio_002807 O=c1cccc2[C@@H]3CNCC(C3)Cn21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M10 compound treatment 9.1015954E7 -2.02E7 -1.16 9.1092905E7 -1.52E7 -0.93 -1.4795 -0.9944 955 SPBio_002808 CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M11 compound treatment 8.6580922E7 -2.47E7 -1.41 8.839673E7 -1.79E7 -1.1 -1.7762 -0.9925 1039072 SPBio_002809 CN1C2CCCC1CC(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M12 compound treatment 5.0326486E7 -6.09E7 -3.48 2.9301979E7 -7.7E7 -4.74 -5.8172 -0.9885 1286 SPBio_002810 Cc1cc(ccc1OCCOCC[N+](C)(C)Cc2ccccc2)C(C)(C)CC(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M13 compound treatment 8.2152558E7 -2.91E7 -1.66 7.894516E7 -2.73E7 -1.68 -2.3672 -1.0 3189579 SPBio_002811 CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M14 compound treatment 7.3512057E7 -3.78E7 -2.16 7.3111816E7 -3.31E7 -2.04 -2.9706 -0.9996 863 SPBio_002812 CN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M15 compound treatment 7.7299076E7 -3.4E7 -1.94 8.067292E7 -2.56E7 -1.58 -2.488 -0.9947 3069527 SPBio_002813 Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@H](CCC(=O)O)C(=O)O)cnc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M16 compound treatment 8.3050794E7 -2.82E7 -1.61 8.0905977E7 -2.54E7 -1.56 -2.2454 -0.9999 1441 SPBio_002814 CN1CCC(CC1)OC(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M17 compound treatment 8.2443512E7 -2.88E7 -1.65 8.4631236E7 -2.16E7 -1.33 -2.1076 -0.9945 3189580 SPBio_002815 C[C@@H]1NCCc2cc(O)c(O)cc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M18 compound treatment 5.5320633E7 -5.59E7 -3.2 4.2306819E7 -6.4E7 -3.94 -5.0485 -0.9946 1373 SPBio_002816 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M19 compound treatment 9.4971392E7 -1.63E7 -0.93 8.9952791E7 -1.63E7 -1.01 -1.3693 -0.9993 1014994 SPBio_002817 CN(C)Cc1c[nH]c2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M20 compound treatment 8.7976466E7 -2.33E7 -1.33 8.5247961E7 -2.1E7 -1.3 -1.8571 -0.9999 1012 SPBio_002818 Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M21 compound treatment 9.9254058E7 -1.2E7 -0.69 9.2530481E7 -1.37E7 -0.85 -1.0839 -0.9946 3189581 SPBio_002819 CCCCc1cc2ccccc2c(OCCN(C)C)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M22 compound treatment 3.0796407E7 -8.05E7 -4.6 2.9540131E7 -7.67E7 -4.73 -6.596 -0.9999 2117332 SPBio_002820 C[C@@]12CC[C@H]3[C@@H](CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]2(O)CC[C@@H]1C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M23 mock treatment 9.3712543E7 -1.76E7 -1.0 9.5988041E7 -1.03E7 -0.63 -1.1571 -0.9754 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 M24 mock treatment 1.05116497E8 -6150000.0 -0.35 9.9803836E7 -6460000.0 -0.4 -0.53 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N01 mock treatment 1.19836782E8 8570000.0 0.49 1.10803394E8 4540000.0 0.28 0.5444 0.9648 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N02 mock treatment 1.1660909E8 5340000.0 0.31 1.09743523E8 3480000.0 0.21 0.3677 0.9851 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N03 compound treatment 3.273529E7 -7.85E7 -4.49 3.1722736E7 -7.45E7 -4.59 -6.4226 -0.9999 3069627 SPBio_002821 CCC(=O)OC1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)CCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N04 compound treatment 1.05637376E8 -5630000.0 -0.32 9.6921137E7 -9340000.0 -0.58 -0.6346 -0.9622 1764 SPBio_002822 NCC1(CC(=O)O)CCCCC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N05 compound treatment 4.2525667E7 -6.87E7 -3.93 4.0527831E7 -6.57E7 -4.05 -5.6431 -0.9999 1001531 SPBio_002823 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N06 compound treatment 1.00014594E8 -1.13E7 -0.64 9.2195203E7 -1.41E7 -0.87 -1.0678 -0.9892 1694 SPBio_002824 Oc1ccc(cc1)c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N07 compound treatment 9.2297513E7 -1.9E7 -1.08 9.292821E7 -1.33E7 -0.82 -1.3477 -0.9907 877 SPBio_002825 CC(C)(Oc1ccc(Cl)cc1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N08 compound treatment 9.4103226E7 -1.72E7 -0.98 9.0529744E7 -1.57E7 -0.97 -1.3793 -1.0 2764 SPBio_002826 CC(O)(P(=O)(O)O)P(=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N09 compound treatment 9.5342066E7 -1.59E7 -0.91 8.9398472E7 -1.69E7 -1.04 -1.3785 -0.9978 917 SPBio_002827 NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N10 compound treatment 9.0255879E7 -2.1E7 -1.2 8.8009988E7 -1.83E7 -1.13 -1.6446 -0.9995 3069700 SPBio_002828 C[C@H]1NC(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N11 compound treatment 8.1569713E7 -2.97E7 -1.7 8.5980164E7 -2.03E7 -1.25 -2.0841 -0.9887 1481 SPBio_002829 Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc4ccccc14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N12 compound treatment 6.3650418E7 -4.76E7 -2.72 6.9198412E7 -3.71E7 -2.28 -3.5397 -0.9962 1000094 SPBio_002830 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N13 compound treatment 7.6119872E7 -3.51E7 -2.01 8.3048165E7 -2.32E7 -1.43 -2.4321 -0.9862 3092 SPBio_002831 Cn1ccnc1S 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N14 compound treatment 4.9484391E7 -6.18E7 -3.53 5.1206758E7 -5.51E7 -3.39 -4.8964 -0.9998 3187895 SPBio_002832 Nc1ncn(C2O[C@H](CO)[C@H](O)[C@@H]2O)c(=O)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N15 compound treatment 7.8614267E7 -3.27E7 -1.87 8.5668434E7 -2.06E7 -1.27 -2.2171 -0.9824 1043 SPBio_002833 O[Hg]c1c(O)c(Br)cc2c(c3ccccc3C(=O)O)c4cc(Br)c(=O)cc4oc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N16 compound treatment 8.124776E7 -3.0E7 -1.72 7.9370756E7 -2.69E7 -1.66 -2.3852 -0.9999 3187896 SPBio_002834 NCC1OC(O[C@@H]2C(O)[C@H](OC3C(O)C(N)CC(N)C3OC4OC(CO)C(O)C(O)C4N)O[C@@H]2CO)C(N)C(O)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N17 compound treatment 8.5569376E7 -2.57E7 -1.47 8.6368951E7 -1.99E7 -1.23 -1.9055 -0.996 3187761 SPBio_002835 CC(CNC1CCCCC1)OC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N18 compound treatment 8.3038593E7 -2.82E7 -1.61 8.2605667E7 -2.37E7 -1.46 -2.1718 -0.9987 1267 SPBio_002836 CC(=O)Nc1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N19 compound treatment 8.8289111E7 -2.3E7 -1.31 8.0208682E7 -2.61E7 -1.61 -2.0641 -0.995 793 SPBio_002837 CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N20 compound treatment 9.9037012E7 -1.22E7 -0.7 9.5448602E7 -1.08E7 -0.67 -0.9655 -0.9997 1604 SPBio_002838 OC(=O)c1ccccc1C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccs3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N21 compound treatment 4.0594263E7 -7.07E7 -4.04 3.8071346E7 -6.82E7 -4.2 -5.8282 -0.9998 2080598 SPBio_002839 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC2CC(=O)NC(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N22 compound treatment 6.1270393E7 -5.0E7 -2.86 5.7909103E7 -4.84E7 -2.98 -4.128 -0.9998 2137 SPBio_002840 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccc(O)c(O)c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N23 mock treatment 9.5946338E7 -1.53E7 -0.88 8.6346053E7 -1.99E7 -1.23 -1.4871 -0.9863 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 N24 mock treatment 1.03375805E8 -7890000.0 -0.45 9.6199327E7 -1.01E7 -0.62 -0.7574 -0.9877 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O01 mock treatment 1.20035413E8 8770000.0 0.5 1.11723538E8 5460000.0 0.34 0.5925 0.9813 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O02 mock treatment 1.08733698E8 -2530000.0 -0.14 9.9124539E7 -7140000.0 -0.44 -0.4134 -0.8927 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O03 compound treatment 9.8240941E7 -1.3E7 -0.74 8.7078796E7 -1.92E7 -1.18 -1.3625 -0.9751 3382 SPBio_002841 Cc1c(CCO)sc[n+]1Cc2cnc(C)nc2N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O04 compound treatment 1.05040716E8 -6230000.0 -0.36 9.4730081E7 -1.15E7 -0.71 -0.7542 -0.9488 1155 SPBio_002842 Nc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O05 compound treatment 9.3140277E7 -1.81E7 -1.04 8.998096E7 -1.63E7 -1.0 -1.4421 -0.9999 3487152 SPBio_002843 CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O06 compound treatment 9.4642101E7 -1.66E7 -0.95 9.4226241E7 -1.2E7 -0.74 -1.1964 -0.9925 1513 SPBio_002844 CCOC(=O)c1ccc(N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O07 compound treatment 8.9927706E7 -2.13E7 -1.22 9.0492423E7 -1.58E7 -0.97 -1.5496 -0.9937 2041 SPBio_002845 OC(=O)CNC(=O)C(CS)Cc1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O08 compound treatment 9.5082486E7 -1.62E7 -0.92 9.2098849E7 -1.42E7 -0.87 -1.2713 -0.9996 1242 SPBio_002846 CN(CS(=O)(=O)O)c1c(C)n(C)n(c2ccccc2)c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O09 compound treatment 9.0574672E7 -2.07E7 -1.18 9.1926479E7 -1.43E7 -0.88 -1.461 -0.9897 1015808 SPBio_002847 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)CO)c2cc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O10 compound treatment 8.7661754E7 -2.36E7 -1.35 9.0004123E7 -1.63E7 -1.0 -1.6625 -0.9893 1064 SPBio_002848 [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O11 compound treatment 8.7379944E7 -2.39E7 -1.37 9.0321712E7 -1.59E7 -0.98 -1.66 -0.987 3189582 SPBio_002849 CC[C@H]1CN2CCC1C[C@H]2[C@H](O)c3ccnc4ccc(OC)cc34 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O12 compound treatment 8.7694543E7 -2.36E7 -1.35 8.191938E7 -2.43E7 -1.5 -2.0136 -0.9986 1668673 SPBio_002850 Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O13 compound treatment 8.2346106E7 -2.89E7 -1.65 8.5347882E7 -2.09E7 -1.29 -2.0803 -0.9924 824 SPBio_002851 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@@](O)(C(=O)OC)n4c5ccccc35 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O14 compound treatment 8.7937531E7 -2.33E7 -1.33 8.8361538E7 -1.79E7 -1.1 -1.7229 -0.9956 1467 SPBio_002852 CCCCOc1ccc(OCCCN2CCOCC2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O15 compound treatment 6.8688465E7 -4.26E7 -2.43 6.8448141E7 -3.78E7 -2.33 -3.3688 -0.9998 3069528 SPBio_002853 C/C=C\1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O16 compound treatment 8.5142865E7 -2.61E7 -1.49 7.7871568E7 -2.84E7 -1.75 -2.2931 -0.9969 3069574 SPBio_002854 CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O17 compound treatment 9.6798754E7 -1.45E7 -0.83 8.2121416E7 -2.41E7 -1.49 -1.6368 -0.9615 3187609 SPBio_002855 C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O18 compound treatment 3.4603684E7 -7.67E7 -4.38 3.2835284E7 -7.34E7 -4.53 -6.2986 -0.9999 2081008 SPBio_002856 C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O19 compound treatment 9.0416177E7 -2.08E7 -1.19 8.5906471E7 -2.04E7 -1.25 -1.7298 -0.9997 3187610 SPBio_002857 CC[C@@H](C)C(=O)O[C@H]1[C@H](O)[C@H]2[C@@H](CN3C[C@@H](C)CC[C@H]3[C@@]2(C)O)C4C[C@]5(O[C@]6(O)[C@H]7[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@H]5[C@@]41O)[C@@]7(C)CC[C@@H]6OC(=O)C(C)(O)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O20 compound treatment 8.505231E7 -2.62E7 -1.5 8.2251355E7 -2.4E7 -1.48 -2.1059 -1.0 759 SPBio_002858 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O21 compound treatment 1.01240875E8 -1.0E7 -0.57 8.5883606E7 -2.04E7 -1.26 -1.2933 -0.9368 3069529 SPBio_002859 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]6(C[C@@H](O[C@@H]7OC(CO)[C@@H](O)[C@@H](O)C7O)[C@@H](O)C(CO)O6)O[C@H]8OC(C)[C@H](O)[C@H](O)C8O)N9C[C@@H](C)CC[C@H]19 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O22 compound treatment 9.0413074E7 -2.09E7 -1.19 8.8256193E7 -1.8E7 -1.11 -1.6275 -0.9994 3187749 SPBio_002860 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)N)\c3ccco3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O23 mock treatment 9.6206865E7 -1.51E7 -0.86 9.3215027E7 -1.3E7 -0.8 -1.1772 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 O24 mock treatment 1.06558136E8 -4710000.0 -0.27 1.05186609E8 -1070000.0 -0.07 -0.2371 -0.8556 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P01 mock treatment 1.23293467E8 1.2E7 0.69 1.13797171E8 7540000.0 0.46 0.8146 0.9818 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P02 mock treatment 1.18361552E8 7100000.0 0.41 1.09587688E8 3330000.0 0.21 0.4318 0.9501 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P03 compound treatment 1.09957728E8 -1310000.0 -0.07 9.7863087E7 -8400000.0 -0.52 -0.4189 -0.8009 890 SPBio_002861 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P04 compound treatment 1.14106745E8 2840000.0 0.16 9.5921516E7 -1.03E7 -0.64 -0.3359 -0.5107 3069701 SPBio_002862 C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P05 compound treatment 1.09089866E8 -2180000.0 -0.12 9.315684E7 -1.31E7 -0.81 -0.6591 -0.8065 244 SPBio_002863 CC[N+](C)(CC)CCC[n+]1c(c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P06 compound treatment 1.09267639E8 -2000000.0 -0.11 9.3418315E7 -1.28E7 -0.79 -0.6405 -0.8008 3487261 SPBio_002864 COCC(=O)Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)N(C)CC(O)CO)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P07 compound treatment 8.8464181E7 -2.28E7 -1.3 9.0433045E7 -1.58E7 -0.98 -1.6114 -0.9898 1431 SPBio_002865 Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P08 compound treatment 9.3066594E7 -1.82E7 -1.04 8.541745E7 -2.08E7 -1.28 -1.644 -0.9945 856 SPBio_002866 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P09 compound treatment 9.4261434E7 -1.7E7 -0.97 9.1665265E7 -1.46E7 -0.9 -1.3234 -0.9993 3187762 SPBio_002867 CC1CC(CC(C)(C)N1C)OC(=O)C(O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P10 compound treatment 9.0036644E7 -2.12E7 -1.21 8.2038571E7 -2.42E7 -1.49 -1.9137 -0.9947 1222 SPBio_002868 Cn1cnc2n(C)c(=O)[nH]c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P11 compound treatment 8.729675E7 -2.4E7 -1.37 8.5284281E7 -2.1E7 -1.29 -1.883 -0.9996 3383 SPBio_002869 Cc1cc(no1)C(=O)NNCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P12 compound treatment 8.7766241E7 -2.35E7 -1.34 8.0536096E7 -2.57E7 -1.59 -2.071 -0.9966 687 SPBio_002870 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P13 compound treatment 8.946386E7 -2.18E7 -1.25 8.1118422E7 -2.51E7 -1.55 -1.977 -0.9941 2105063 SPBio_002871 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P14 compound treatment 7.2431687E7 -3.88E7 -2.22 7.557507E7 -3.07E7 -1.89 -2.9069 -0.9968 989 SPBio_002872 NC(=N)NCCCCNC(=N)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P15 compound treatment 6.0202177E7 -5.11E7 -2.92 5.9698755E7 -4.66E7 -2.87 -4.0931 -1.0 2752 SPBio_002873 COc1ccc2Sc3ccccc3N(C[C@H](C)CN(C)C)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P16 compound treatment 8.0519083E7 -3.07E7 -1.76 7.9570519E7 -2.67E7 -1.65 -2.4059 -0.9995 3060919 SPBio_002874 CN1C2CC(CC1C3OC32)OC(=O)[C@H](CO)c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P17 compound treatment 7.9626348E7 -3.16E7 -1.81 6.9076336E7 -3.72E7 -2.29 -2.8994 -0.9931 1370 SPBio_002875 C/C=C(/C(=C/C)/c1ccc(O)cc1)\c2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P18 compound treatment 8.455752E7 -2.67E7 -1.53 8.1921667E7 -2.43E7 -1.5 -2.1402 -1.0 3487262 SPBio_002876 OCCN(C(=O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P19 compound treatment 8.959144E7 -2.17E7 -1.24 8.8296956E7 -1.8E7 -1.11 -1.6589 -0.9984 1328 SPBio_002877 OC(CCN1CCCCC1)(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P20 compound treatment 5.2220382E7 -5.9E7 -3.37 4.0056503E7 -6.62E7 -4.08 -5.2719 -0.9955 446 SPBio_002878 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P21 compound treatment 9.9508759E7 -1.18E7 -0.67 9.5141406E7 -1.11E7 -0.69 -0.9598 -1.0 794 SPBio_002879 Nc1cc(c[nH]c1=O)c2ccncc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P22 compound treatment 9.5624895E7 -1.56E7 -0.89 9.2258101E7 -1.4E7 -0.86 -1.2424 -0.9998 1327 SPBio_002880 C[N+](C)(C)CCOC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P23 mock treatment 1.00991032E8 -1.03E7 -0.59 1.00210214E8 -6050000.0 -0.37 -0.679 -0.976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2166 P24 mock treatment 1.11013166E8 -253000.0 -0.01 1.09013991E8 2750000.0 0.17 0.1098 0.6446 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A01 mock treatment 1.30376719E8 2.85E7 1.63 1.29322411E8 2.85E7 1.76 2.3926 0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A02 mock treatment 1.2577573E8 2.39E7 1.36 1.21874843E8 2.11E7 1.3 1.8821 0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A03 compound treatment 1.19458974E8 1.75E7 1.0 1.19935724E8 1.91E7 1.18 1.5423 0.9968 1300 SPBio_002881 OC(=O)c1cccnc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A04 compound treatment 1.28837958E8 2.69E7 1.54 1.27486082E8 2.67E7 1.64 2.2504 0.9995 1073908 SPBio_002882 CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A05 compound treatment 1.14588147E8 1.27E7 0.72 1.11597338E8 1.08E7 0.66 0.982 0.9991 2819 SPBio_002883 CCC1(C)CC(=O)NC(=O)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A06 compound treatment 1.18264727E8 1.63E7 0.93 1.06762658E8 5950000.0 0.37 0.9198 0.9165 1322 SPBio_002884 COc1cc2ccc(=O)oc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A07 compound treatment 3.1905782E7 -7.0E7 -4.0 3.2587218E7 -6.82E7 -4.21 -5.8033 -0.9997 3187897 SPBio_002885 C[C@]12[C@H](CC[C@]2(O)[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]1O)C5=CC(=O)OC5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A08 compound treatment 1.07433028E8 5520000.0 0.32 1.12890156E8 1.21E7 0.74 0.7492 0.9269 1081653 SPBio_002886 Clc1ccc(C(Cn2ccnc2)OCC=C)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A09 compound treatment 9.6065195E7 -5850000.0 -0.33 1.10227929E8 9410000.0 0.58 0.1737 0.2595 4370 SPBio_002887 CNCC(O)C(O)C(O)C(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A10 compound treatment 1.16343321E8 1.44E7 0.82 1.23649994E8 2.28E7 1.41 1.5783 0.9675 1203 SPBio_002888 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A11 compound treatment 3.0055418E7 -7.19E7 -4.11 3.0858311E7 -7.0E7 -4.31 -5.9534 -0.9997 3172726 SPBio_002889 C[C@]12C3CCC(O3)[C@]2(C)C(=O)OC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A12 compound treatment 9.6512831E7 -5400000.0 -0.31 1.05101289E8 4280000.0 0.26 -0.0316 -0.0779 2060138 SPBio_002890 C[C@]1([C@H]2[C@H](C(=O)O)[C@]3(CC(=C)[C@@]4(O)C3)[C@@H](CC4)[C@]52OC1=O)[C@@H](O)C=C5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A13 compound treatment 9.2627485E7 -9290000.0 -0.53 1.02961463E8 2140000.0 0.13 -0.2819 -0.5153 1999 SPBio_002891 Oc1c(I)cc(Cl)c2cccnc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A14 compound treatment 9.8374122E7 -3540000.0 -0.2 1.07855971E8 7040000.0 0.43 0.1637 0.3418 3480627 SPBio_002892 CC(C)NCC(O)c1ccc(NS(=O)(=O)C)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A15 compound treatment 9.8011652E7 -3900000.0 -0.22 1.07894306E8 7080000.0 0.44 0.1507 0.3075 838 SPBio_002893 COc1ccc(C(=O)c2ccccc2)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A16 compound treatment 9.6564195E7 -5350000.0 -0.31 1.09801301E8 8980000.0 0.55 0.1753 0.2771 3188025 SPBio_002894 CN1C2CC(O)C1CC(=O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A17 compound treatment 9.4327881E7 -7590000.0 -0.43 1.06367903E8 5550000.0 0.34 -0.0647 -0.1172 681 SPBio_002895 CC(CN1c2ccccc2Sc3ccccc13)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A18 compound treatment 1.17615955E8 1.57E7 0.9 1.19389294E8 1.86E7 1.14 1.444 0.9927 3855 SPBio_002896 C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A19 compound treatment 9.2046064E7 -9870000.0 -0.56 1.05501873E8 4680000.0 0.29 -0.1947 -0.3072 1225 SPBio_002897 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A20 compound treatment 1.03038515E8 1120000.0 0.06 1.14708554E8 1.39E7 0.86 0.6508 0.758 1040327 SPBio_002898 CC(=O)Nc1cc2ccccc2oc1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A21 compound treatment 1.03718277E8 1800000.0 0.1 1.13726473E8 1.29E7 0.8 0.6355 0.792 3487233 SPBio_002899 CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A22 compound treatment 1.06609793E8 4690000.0 0.27 1.16725433E8 1.59E7 0.98 0.8831 0.8686 1120 SPBio_002900 Oc1ccc(cc1[N+](=O)[O-])[As](=O)(O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A23 mock treatment 1.09524308E8 7610000.0 0.43 1.17850189E8 1.7E7 1.05 1.0499 0.9239 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 A24 mock treatment 1.18397818E8 1.65E7 0.94 1.27377686E8 2.66E7 1.64 1.8238 0.9655 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B01 mock treatment 1.32781996E8 3.09E7 1.76 1.30822457E8 3.0E7 1.85 2.5552 0.9997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B02 mock treatment 1.08558252E8 6640000.0 0.38 1.09615564E8 8800000.0 0.54 0.6519 0.9848 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B03 compound treatment 1.08718852E8 6800000.0 0.39 1.06574728E8 5760000.0 0.35 0.5259 0.999 3069812 SPBio_002901 CCOC(=O)c1cncn1C(C)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B04 mock treatment 1.05202092E8 3290000.0 0.19 1.04656645E8 3840000.0 0.24 0.3001 0.9934 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B05 compound treatment 1.11861313E8 9950000.0 0.57 9.950219E7 -1320000.0 -0.08 0.3446 0.6002 3188157 SPBio_002902 CC[N+](CC)(CC)CCC(O)(C1CCCCC1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B06 mock treatment 1.04953832E8 3040000.0 0.17 1.03280591E8 2460000.0 0.15 0.2301 0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B07 compound treatment 8.7996047E7 -1.39E7 -0.8 9.2737291E7 -8080000.0 -0.5 -0.9147 -0.9746 3487585 SPBio_002903 CC(C)(C)NCC(O)COc1ccccc1C2CCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B08 mock treatment 9.7169991E7 -4750000.0 -0.27 9.6524254E7 -4290000.0 -0.26 -0.3789 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B09 compound treatment 3.7266055E7 -6.46E7 -3.69 4.0167282E7 -6.07E7 -3.74 -5.2563 -1.0 3188158 SPBio_002904 CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C)C(=O)COC(=O)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B10 mock treatment 9.4031538E7 -7880000.0 -0.45 9.7280823E7 -3540000.0 -0.22 -0.4728 -0.9445 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B11 compound treatment 8.2167779E7 -1.97E7 -1.13 8.9318617E7 -1.15E7 -0.71 -1.2993 -0.9749 3069813 SPBio_002905 Clc1ccc(C(Cn2ccnc2)OCc3csc4c(Cl)cccc34)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B12 mock treatment 9.5046435E7 -6870000.0 -0.39 9.6137803E7 -4680000.0 -0.29 -0.4816 -0.9885 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B13 compound treatment 8.1642875E7 -2.03E7 -1.16 9.5472639E7 -5340000.0 -0.33 -1.0523 -0.8735 3188159 SPBio_002906 CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B14 mock treatment 8.8981226E7 -1.29E7 -0.74 9.901E7 -1810000.0 -0.11 -0.6015 -0.8046 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B15 compound treatment 9.7600425E7 -4320000.0 -0.25 9.5447053E7 -5370000.0 -0.33 -0.4085 -0.9895 3168 SPBio_002907 NS(=O)(=O)c1cc(cc(N2CCCC2)c1Oc3ccccc3)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B16 mock treatment 8.6884681E7 -1.5E7 -0.86 9.597655E7 -4840000.0 -0.3 -0.8185 -0.9 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B17 compound treatment 8.8733349E7 -1.32E7 -0.75 9.8351127E7 -2470000.0 -0.15 -0.6402 -0.833 3188160 SPBio_002908 CC(=O)c1ccc2Sc3ccccc3N(CCCN4CCC(CCO)CC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B18 mock treatment 8.8737012E7 -1.32E7 -0.75 9.5299487E7 -5520000.0 -0.34 -0.7731 -0.9355 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B19 compound treatment 2.9758824E7 -7.22E7 -4.12 4.1836376E7 -5.9E7 -3.64 -5.4869 -0.998 943 SPBio_002909 CCCCC1C(=O)N(N(C1=O)c2ccc(O)cc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B20 mock treatment 1.08039669E8 6120000.0 0.35 1.11451189E8 1.06E7 0.66 0.711 0.9568 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B21 compound treatment 9.474063E7 -7180000.0 -0.41 1.01992194E8 1170000.0 0.07 -0.2388 -0.5734 3069814 SPBio_002910 CCC1NC(=O)c2cc(c(Cl)cc2N1)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B22 mock treatment 9.6744163E7 -5170000.0 -0.3 1.03719221E8 2900000.0 0.18 -0.0825 -0.2389 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B23 mock treatment 9.1729639E7 -1.02E7 -0.58 1.00515494E8 -302000.0 -0.02 -0.4248 -0.7293 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 B24 mock treatment 1.07577771E8 5660000.0 0.32 1.21722181E8 2.09E7 1.29 1.14 0.858 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C01 mock treatment 1.1904012E8 1.71E7 0.98 1.14151133E8 1.33E7 0.82 1.2732 0.9962 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C02 mock treatment 1.06525791E8 4610000.0 0.26 1.04918239E8 4100000.0 0.25 0.365 0.9998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C03 compound treatment 1.03996605E8 2080000.0 0.12 1.05922486E8 5110000.0 0.31 0.3066 0.9114 1022907 SPBio_002911 CC(=O)c1cc2ccccc2oc1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C04 compound treatment 1.02617895E8 702000.0 0.04 1.03822344E8 3000000.0 0.19 0.1593 0.8408 3188026 SPBio_002912 CCN1CCC[C@H]1CNC(=O)c2c(OC)ccc(Br)c2OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C05 compound treatment 9.0890443E7 -1.1E7 -0.63 4.4221503E7 -5.66E7 -3.49 -2.9125 -0.8215 3187898 SPBio_002913 OCC1O[C@@H](Oc2cc3ccc(=O)oc3cc2O)C(O)[C@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C06 compound treatment 1.14404449E8 1.25E7 0.71 1.04702739E8 3890000.0 0.24 0.674 0.8953 864 SPBio_002914 Oc1noc2CNCCc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C07 compound treatment 1.10110164E8 8190000.0 0.47 9.4505419E7 -6310000.0 -0.39 0.056 0.092 2776 SPBio_002915 OC(=O)Cc1ccc(cc1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C08 compound treatment 9.5904125E7 -6010000.0 -0.34 9.6847232E7 -3970000.0 -0.24 -0.416 -0.9862 1134931 SPBio_002916 Cc1ccc2n3CCNC4CCCc(c43)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C09 compound treatment 9.9547733E7 -2370000.0 -0.14 9.6790338E7 -4030000.0 -0.25 -0.2712 -0.9593 1012530 SPBio_002917 CCCCOC(=O)c1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C10 compound treatment 9.4536164E7 -7380000.0 -0.42 9.7106663E7 -3710000.0 -0.23 -0.46 -0.9587 1512 SPBio_002918 CC(C)NCC(O)c1ccc2ccccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C11 compound treatment 1.06027051E8 4110000.0 0.23 9.9844163E7 -973000.0 -0.06 0.1237 0.5102 1299 SPBio_002919 Nc1ccc(cc1)C(=O)NCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C12 compound treatment 8.2749628E7 -1.92E7 -1.1 7.252E7 -2.83E7 -1.74 -2.008 -0.9749 3480607 SPBio_002920 COc1ccccc1N2CCN(CC(O)COc3cccc4ccccc34)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C13 compound treatment 9.9911553E7 -2000000.0 -0.11 9.7132033E7 -3690000.0 -0.23 -0.2416 -0.9498 1231 SPBio_002921 CC(C)C[C@H](NC(=O)C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C14 compound treatment 1.03287196E8 1370000.0 0.08 8.9937515E7 -1.09E7 -0.67 -0.4188 -0.6203 907524 SPBio_002922 CCCCNc1c(C(=O)OCC)c(C)nc2n(CC)ncc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C15 compound treatment 8.2633387E7 -1.93E7 -1.1 8.9590954E7 -1.12E7 -0.69 -1.2686 -0.9749 1258 SPBio_002923 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCNCC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C16 compound treatment 7.682019E7 -2.51E7 -1.43 8.8645388E7 -1.22E7 -0.75 -1.5447 -0.9543 2372 SPBio_002924 COc1cc(ccc1OC(F)F)c2ccc(=O)[nH]n2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C17 compound treatment 7.6982985E7 -2.49E7 -1.42 9.2288238E7 -8530000.0 -0.53 -1.3794 -0.9082 3059213 SPBio_002925 COc1ccc(C(=O)c2ccccc2O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C18 compound treatment 9.5353984E7 -6560000.0 -0.38 9.218004E7 -8640000.0 -0.53 -0.6417 -0.9853 733 SPBio_002926 CC1(CC2CC3(C)C1)CC(N)(C2)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C19 compound treatment 1.10922671E8 9010000.0 0.51 9.5841168E7 -4980000.0 -0.31 0.1471 0.2454 3187899 SPBio_002927 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C20 compound treatment 1.03240065E8 1320000.0 0.08 9.7069484E7 -3750000.0 -0.23 -0.1099 -0.4519 2742 SPBio_002928 OC(=O)/C=C/c1ccc(Cn2ccnc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C21 compound treatment 9.8240546E7 -3680000.0 -0.21 9.4638214E7 -6180000.0 -0.38 -0.4179 -0.9607 1019709 SPBio_002929 C[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C22 compound treatment 1.04015867E8 2100000.0 0.12 9.3921276E7 -6900000.0 -0.43 -0.2157 -0.4884 2245 SPBio_002930 C(N1CCN(CC1)c2ncccn2)c3ccc4OCOc4c3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C23 mock treatment 9.5774761E7 -6140000.0 -0.35 9.3402326E7 -7420000.0 -0.46 -0.5714 -0.9915 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 C24 mock treatment 1.1806996E8 1.62E7 0.92 1.19854612E8 1.9E7 1.17 1.4826 0.993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D01 mock treatment 1.22112015E8 2.02E7 1.15 1.11004134E8 1.02E7 0.63 1.2602 0.9591 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D02 mock treatment 1.04872755E8 2960000.0 0.17 1.0309997E8 2280000.0 0.14 0.219 0.9959 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D03 compound treatment 1.09302555E8 7390000.0 0.42 1.06196528E8 5380000.0 0.33 0.533 0.9929 1267101 SPBio_002931 CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN4CCOCC4)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D04 mock treatment 1.14380008E8 1.25E7 0.71 1.09165438E8 8350000.0 0.51 0.8676 0.9873 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D05 compound treatment 1.10447124E8 8530000.0 0.49 1.02926779E8 2110000.0 0.13 0.4367 0.8654 1487 SPBio_002932 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D06 mock treatment 1.08922624E8 7010000.0 0.4 1.07080527E8 6260000.0 0.39 0.5561 0.9998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D07 compound treatment 1.05435067E8 3520000.0 0.2 1.01419257E8 602000.0 0.04 0.1684 0.8236 3188161 SPBio_002933 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](/N=C/N3CCCCCC3)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D08 mock treatment 1.07546062E8 5630000.0 0.32 1.03494202E8 2680000.0 0.17 0.3442 0.9519 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D09 compound treatment 1.03361954E8 1450000.0 0.08 7.7145248E7 -2.37E7 -1.46 -0.9734 -0.666 3188162 SPBio_002934 CCC(=O)OC(Cc1ccccc1)(C(C)CN(C)C)c2ccccc2.OS(=O)(=O)c1ccc2ccccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D10 mock treatment 1.02307507E8 392000.0 0.02 9.0790555E7 -1.0E7 -0.62 -0.4212 -0.6811 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D11 compound treatment 1.08235806E8 6320000.0 0.36 1.03323592E8 2510000.0 0.15 0.3646 0.9282 772 SPBio_002935 CCN1CCCC(C1)OC(=O)C(c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D12 mock treatment 1.0455576E8 2640000.0 0.15 9.3800029E7 -7020000.0 -0.43 -0.1992 -0.4348 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D13 compound treatment 3.6148887E7 -6.58E7 -3.76 3.5450243E7 -6.54E7 -4.03 -5.507 -0.9994 3069815 SPBio_002936 OC[C@H]1O[C@H](C[C@H]1O)n2cc(c(=O)[nH]c2=O)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D14 mock treatment 9.7907714E7 -4010000.0 -0.23 9.2679607E7 -8140000.0 -0.5 -0.5167 -0.9369 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D15 compound treatment 1.02603092E8 687000.0 0.04 8.9238245E7 -1.16E7 -0.71 -0.4769 -0.6672 1001977 SPBio_002937 CC(C)NCC(O)COc1ccccc1OCC=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D16 mock treatment 1.01497923E8 -418000.0 -0.02 1.0190105E8 1080000.0 0.07 0.0303 0.4276 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D17 compound treatment 1.03454172E8 1540000.0 0.09 9.5717674E7 -5100000.0 -0.31 -0.1601 -0.4906 1434439 SPBio_002938 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D18 mock treatment 1.03920391E8 2000000.0 0.11 9.7619081E7 -3200000.0 -0.2 -0.0584 -0.2562 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D19 compound treatment 1.03892869E8 1980000.0 0.11 9.6070557E7 -4750000.0 -0.29 -0.127 -0.4049 3069816 SPBio_002939 CCCOc1cc(N)ccc1C(=O)OCCN(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D20 mock treatment 1.03211662E8 1300000.0 0.07 9.3381971E7 -7440000.0 -0.46 -0.2717 -0.5853 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D21 compound treatment 1.00519109E8 -1400000.0 -0.08 9.4791758E7 -6030000.0 -0.37 -0.3191 -0.8399 1672 SPBio_002940 OC(=O)CCc1nc(c(o1)c2ccccc2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D22 mock treatment 1.00536624E8 -1380000.0 -0.08 9.7149165E7 -3670000.0 -0.23 -0.2156 -0.9005 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D23 mock treatment 1.0160569E8 -310000.0 -0.02 1.02426117E8 1610000.0 0.1 0.0576 0.5716 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 D24 mock treatment 1.12303092E8 1.04E7 0.59 1.11925086E8 1.11E7 0.68 0.9039 0.9975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E01 mock treatment 1.05977999E8 4060000.0 0.23 1.05500286E8 4680000.0 0.29 0.3683 0.9942 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E02 mock treatment 1.11442193E8 9530000.0 0.54 1.01664092E8 847000.0 0.05 0.4219 0.7714 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E03 compound treatment 1.08823031E8 6910000.0 0.39 1.00511003E8 -306000.0 -0.02 0.2658 0.6725 2732 SPBio_002941 Cc1cc(=O)oc2cc(O)ccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E04 compound treatment 1.1282733E8 1.09E7 0.62 1.09321438E8 8500000.0 0.52 0.8116 0.9963 3188027 SPBio_002942 CCN(CC)CCOC(=O)C1(CCCC1)c2ccc(cc2)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E05 compound treatment 1.02942403E8 1030000.0 0.06 1.03306381E8 2490000.0 0.15 0.15 0.913 1978 SPBio_002943 OC(=O)/C=C/c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E06 compound treatment 1.01951581E8 35600.0 0.0 9.9294668E7 -1520000.0 -0.09 -0.0649 -0.6916 2098610 SPBio_002944 C1CC1C(NC2=NCCO2)C3CC3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E07 compound treatment 1.04773056E8 2860000.0 0.16 9.8765446E7 -2050000.0 -0.13 0.026 0.126 3069737 SPBio_002945 CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E08 compound treatment 1.02670543E8 755000.0 0.04 1.00922037E8 105000.0 0.01 0.0351 0.8039 3723 SPBio_002946 CN(C)CCCSC(=N)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E09 compound treatment 9.9969347E7 -1950000.0 -0.11 9.9722245E7 -1100000.0 -0.07 -0.1264 -0.9713 2743 SPBio_002947 CC(C)(C(=O)c1cccnc1)c2cccnc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E10 compound treatment 9.891104E7 -3000000.0 -0.17 9.5322349E7 -5500000.0 -0.34 -0.361 -0.9504 3069774 SPBio_002948 CO[C@H]1[C@H](O)C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E11 compound treatment 9.8734115E7 -3180000.0 -0.18 9.6736881E7 -4080000.0 -0.25 -0.3065 -0.9873 3202 SPBio_002949 COc1ccccc1N2CCN(CCCNc3cc(=O)n(C)c(=O)n3C)CC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E12 compound treatment 9.889889E7 -3020000.0 -0.17 9.580779E7 -5010000.0 -0.31 -0.3403 -0.9621 3069775 SPBio_002950 CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E13 compound treatment 9.2234995E7 -9680000.0 -0.55 8.3664746E7 -1.72E7 -1.06 -1.1389 -0.9544 23081 SPBio_002951 Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E14 compound treatment 2.9660629E7 -7.23E7 -4.13 2.9886648E7 -7.09E7 -4.37 -6.0117 -0.9996 3188028 SPBio_002952 CC1O[C@@H](O[C@H]2CC[C@]3(C)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CCC3=C2)c6ccc(=O)oc6)C(O)[C@@H](O)[C@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E15 compound treatment 1.00444505E8 -1470000.0 -0.08 9.6717335E7 -4100000.0 -0.25 -0.2382 -0.8942 1472 SPBio_002953 CC(C)Cc1ccc(cc1)[C@H](C)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E16 compound treatment 2.8237027E7 -7.37E7 -4.21 2.8590909E7 -7.22E7 -4.45 -6.1257 -0.9996 2549 SPBio_002954 C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E17 compound treatment 9.7967533E7 -3950000.0 -0.23 1.01496311E8 679000.0 0.04 -0.13 -0.5663 3187900 SPBio_002955 CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(OC(=O)C)C#C)[C@@H]3CCC2=C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E18 compound treatment 9.767243E7 -4240000.0 -0.24 9.8374118E7 -2440000.0 -0.15 -0.278 -0.9737 3069776 SPBio_002956 C[C@]1(C[C@H](O)[C@@]2(O)C=CO[C@H](OC3OC(CO)C(O)C(O)C3O)C12)OC(=O)/C=C\c4ccccc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E19 compound treatment 1.01647238E8 -269000.0 -0.02 9.4987805E7 -5830000.0 -0.36 -0.265 -0.7367 1440 SPBio_002957 COc1ccc2cc(CCC(=O)C)ccc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E20 compound treatment 1.03107154E8 1190000.0 0.07 9.6661329E7 -4160000.0 -0.26 -0.133 -0.5018 3188029 SPBio_002958 C[C@@H]1CCC2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)C5CC[C@]43C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6OC(CO[C@@H]7OC(CO)[C@@H](O[C@@H]8OC(C)[C@H](O)[C@H](O)C8O)[C@@H](O)C7O)[C@@H](O)[C@@H](O)C6O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E21 compound treatment 9.6108477E7 -5810000.0 -0.33 9.392364E7 -6890000.0 -0.42 -0.5352 -0.9925 907434 SPBio_002959 CNCCC(Oc1ccccc1OC)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E22 compound treatment 9.7881945E7 -4030000.0 -0.23 8.7407783E7 -1.34E7 -0.83 -0.7475 -0.8711 3069777 SPBio_002960 CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E23 mock treatment 1.00203795E8 -1710000.0 -0.1 9.8000255E7 -2820000.0 -0.17 -0.192 -0.9632 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 E24 mock treatment 1.0436966E8 2450000.0 0.14 1.0464896E8 3830000.0 0.24 0.2662 0.969 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F01 mock treatment 1.13248448E8 1.13E7 0.65 1.03588626E8 2770000.0 0.17 0.5788 0.8641 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F02 mock treatment 1.14951116E8 1.3E7 0.74 1.08578847E8 7760000.0 0.48 0.8651 0.9771 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F03 compound treatment 1.10066474E8 8150000.0 0.47 1.04839292E8 4020000.0 0.25 0.5047 0.9564 3188163 SPBio_002961 CN1C(=O)CC(C1=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F04 mock treatment 1.06764164E8 4850000.0 0.28 1.0465899E8 3840000.0 0.24 0.3634 0.9969 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F05 compound treatment 1.05722904E8 3810000.0 0.22 9.9015924E7 -1800000.0 -0.11 0.0753 0.3083 2957 SPBio_002962 CNC(=O)c1c(I)c(N(C)C(=O)C)c(I)c(C(=O)NCC(=O)Nc2c(I)c(C(=O)O)c(I)c(C(=O)NCCO)c2I)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F06 mock treatment 1.00580807E8 -1340000.0 -0.08 9.815792E7 -2660000.0 -0.16 -0.1699 -0.9395 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F07 compound treatment 1.01468539E8 -447000.0 -0.03 9.9795472E7 -1020000.0 -0.06 -0.0626 -0.9211 3069817 SPBio_002963 CN(C/C=C/c1ccccc1)Cc2cccc3ccccc23 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F08 mock treatment 1.00078664E8 -1840000.0 -0.11 9.6713483E7 -4100000.0 -0.25 -0.2531 -0.9242 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F09 compound treatment 1.00570236E8 -1350000.0 -0.08 9.7174303E7 -3640000.0 -0.22 -0.2132 -0.8981 907413 SPBio_002964 CCCNC(C)(C)COC(=O)c1ccccc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F10 mock treatment 9.8957083E7 -2960000.0 -0.17 9.6237572E7 -4580000.0 -0.28 -0.3192 -0.97 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F11 compound treatment 9.6380415E7 -5540000.0 -0.32 9.1384301E7 -9430000.0 -0.58 -0.6349 -0.9591 1666 SPBio_002965 Cc1[nH]c(=O)c(C#N)cc1c2ccncc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F12 mock treatment 9.475819E7 -7160000.0 -0.41 9.0957382E7 -9860000.0 -0.61 -0.719 -0.9814 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F13 compound treatment 9.4921568E7 -6990000.0 -0.4 9.0627688E7 -1.02E7 -0.63 -0.7268 -0.9762 4382 SPBio_002966 CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F14 mock treatment 9.6842704E7 -5070000.0 -0.29 9.7131862E7 -3690000.0 -0.23 -0.3657 -0.9927 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F15 compound treatment 9.8279624E7 -3640000.0 -0.21 9.6011213E7 -4810000.0 -0.3 -0.3564 -0.985 2586 SPBio_002967 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C(=O)O)c3ccsc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F16 mock treatment 9.0732543E7 -1.12E7 -0.64 8.3402791E7 -1.74E7 -1.07 -1.211 -0.9693 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F17 compound treatment 9.4143049E7 -7770000.0 -0.44 8.0520795E7 -2.03E7 -1.25 -1.1988 -0.9029 3188276 SPBio_002968 CCSc1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1.OC(CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F18 mock treatment 9.7521306E7 -4390000.0 -0.25 9.7764761E7 -3050000.0 -0.19 -0.3107 -0.9899 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F19 compound treatment 9.9088596E7 -2830000.0 -0.16 9.9613684E7 -1200000.0 -0.07 -0.1667 -0.9377 1778 SPBio_002969 Nc1ccc(O)c(c1)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F20 mock treatment 9.7394235E7 -4520000.0 -0.26 9.9147351E7 -1670000.0 -0.1 -0.2555 -0.9186 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F21 compound treatment 9.3889682E7 -8030000.0 -0.46 9.4787955E7 -6030000.0 -0.37 -0.5872 -0.9946 3047 SPBio_002970 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(=C3[C@H]2OC1=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F22 mock treatment 9.6537214E7 -5380000.0 -0.31 8.9081021E7 -1.17E7 -0.72 -0.7289 -0.9273 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F23 mock treatment 9.8770557E7 -3150000.0 -0.18 9.2829206E7 -7990000.0 -0.49 -0.4753 -0.9067 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 F24 mock treatment 1.00381794E8 -1530000.0 -0.09 1.08697179E8 7880000.0 0.49 0.2815 0.5702 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G01 mock treatment 1.12252933E8 1.03E7 0.59 1.10482382E8 9660000.0 0.6 0.839 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G02 mock treatment 1.09203218E8 7290000.0 0.42 1.05090562E8 4270000.0 0.26 0.4807 0.9756 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G03 compound treatment 1.1334655E8 1.14E7 0.65 1.06438016E8 5620000.0 0.35 0.7069 0.956 3069738 SPBio_002971 CC(C)NCC(O)c1ccc(O)c(O)c1.OC(C(O)C(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G04 compound treatment 1.1214085E8 1.02E7 0.58 1.10277431E8 9460000.0 0.58 0.8255 1.0 1327636 SPBio_002972 COc1ccc2c(c1)C(=O)N(CCc3ccc(cc3)S(=O)(=O)NC(=O)NC4CCCCC4)C(=O)C2(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G05 compound treatment 5.3364877E7 -4.86E7 -2.77 5.2120748E7 -4.87E7 -3.0 -4.0846 -0.9992 1001471 SPBio_002973 Oc1ccc(OCc2ccccc2)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G06 compound treatment 1.08797431E8 6880000.0 0.39 1.00872717E8 55200.0 0.0 0.2805 0.7132 3069778 SPBio_002974 CN1CCC(=C2c3ccsc3CCc4ccccc24)CC1.OC(CC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G07 compound treatment 1.06721721E8 4810000.0 0.27 1.01145191E8 328000.0 0.02 0.2085 0.7571 1025776 SPBio_002975 Nc1ccccc1S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G08 compound treatment 8.9217683E7 -1.27E7 -0.73 8.3702812E7 -1.71E7 -1.05 -1.2592 -0.9833 3188030 SPBio_002976 NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@H](O)C2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G09 compound treatment 1.02065656E8 150000.0 0.01 9.8397198E7 -2420000.0 -0.15 -0.0994 -0.6655 3060043 SPBio_002977 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2CCC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G10 compound treatment 1.0197239E8 56400.0 0.0 9.9469068E7 -1350000.0 -0.08 -0.0565 -0.6792 1057366 SPBio_002978 NS(=O)(=O)c1cc2c(NC(CC3CCCC3)NS2(=O)=O)cc1Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G11 compound treatment 1.05294444E8 3380000.0 0.19 1.01444941E8 627000.0 0.04 0.1639 0.8322 907370 SPBio_002979 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G12 compound treatment 9.5860763E7 -6060000.0 -0.35 8.8005868E7 -1.28E7 -0.79 -0.8031 -0.9315 3177109 SPBio_002980 COCCCC/C(=N\OCCN)/c1ccc(cc1)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G13 compound treatment 9.4394051E7 -7520000.0 -0.43 9.6056363E7 -4760000.0 -0.29 -0.5115 -0.9827 117 SPBio_002981 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G14 compound treatment 9.9296482E7 -2620000.0 -0.15 9.9501288E7 -1320000.0 -0.08 -0.1632 -0.9586 3069779 SPBio_002982 NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4cccs4)C3=O)C(=O)O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G15 compound treatment 1.00564615E8 -1350000.0 -0.08 1.00436679E8 -381000.0 -0.02 -0.0712 -0.8822 1000135 SPBio_002983 CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G16 compound treatment 3.2225704E7 -6.97E7 -3.98 3.1314558E7 -6.95E7 -4.28 -5.8458 -0.9993 1000221 SPBio_002984 CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)SCF 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G17 compound treatment 9.8553815E7 -3360000.0 -0.19 1.01211031E8 394000.0 0.02 -0.1187 -0.613 115 SPBio_002985 COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G18 compound treatment 9.5394483E7 -6520000.0 -0.37 8.5823751E7 -1.5E7 -0.92 -0.9171 -0.9202 3069780 SPBio_002986 OCCN1CCN(CC/C=C\2/c3ccccc3Sc4ccc(Cl)cc24)CC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G19 compound treatment 9.8713638E7 -3200000.0 -0.18 9.6865633E7 -3950000.0 -0.24 -0.3017 -0.9901 3221506 SPBio_002987 CCC(C)C(N)C1=NC(CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G20 compound treatment 9.8449675E7 -3470000.0 -0.2 8.8089111E7 -1.27E7 -0.78 -0.6949 -0.8587 4480 SPBio_002988 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G21 compound treatment 1.08185502E8 6270000.0 0.36 1.04069182E8 3250000.0 0.2 0.3951 0.9623 1008 SPBio_002989 OC1CCCCC1N2CCC(CC2)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G22 compound treatment 1.0489341E8 2980000.0 0.17 1.06548106E8 5730000.0 0.35 0.3701 0.9439 3188032 SPBio_002990 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCNC(CCCCN)C(=O)O)C(=O)c4c(O)cccc4[C@@]3(C)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G23 mock treatment 1.03103164E8 1190000.0 0.07 9.2249554E7 -8570000.0 -0.53 -0.3255 -0.6112 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 G24 mock treatment 1.12418436E8 1.05E7 0.6 1.0949439E8 8680000.0 0.53 0.8026 0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H01 mock treatment 1.08677486E8 6760000.0 0.39 1.03774372E8 2960000.0 0.18 0.4021 0.9412 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H02 mock treatment 1.15750592E8 1.38E7 0.79 1.0554719E8 4730000.0 0.29 0.7652 0.9081 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H03 compound treatment 1.11974923E8 1.01E7 0.57 1.07492815E8 6680000.0 0.41 0.6975 0.9866 3069853 SPBio_002991 OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H04 mock treatment 1.09708396E8 7790000.0 0.45 1.04622382E8 3800000.0 0.23 0.4808 0.9551 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H05 compound treatment 1.06447993E8 4530000.0 0.26 1.01302842E8 485000.0 0.03 0.2043 0.7836 1503 SPBio_002992 Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H06 mock treatment 1.05601031E8 3690000.0 0.21 1.01647584E8 830000.0 0.05 0.1851 0.8541 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H07 compound treatment 1.03892847E8 1980000.0 0.11 9.9151589E7 -1670000.0 -0.1 0.0073 0.0477 834 SPBio_002993 CC(C[N+](C)(C)C)OC(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H08 mock treatment 9.8415194E7 -3500000.0 -0.2 9.8123437E7 -2690000.0 -0.17 -0.2589 -0.9957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H09 compound treatment 9.7179443E7 -4740000.0 -0.27 9.3388528E7 -7430000.0 -0.46 -0.5152 -0.9685 3188277 SPBio_002994 CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)C5CC5[C@]4(C)[C@H]3CC[C@@]21C)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H10 mock treatment 1.00347985E8 -1570000.0 -0.09 9.7259595E7 -3560000.0 -0.22 -0.2184 -0.922 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H11 compound treatment 9.5497413E7 -6420000.0 -0.37 9.2189987E7 -8630000.0 -0.53 -0.6354 -0.9836 1000206 SPBio_002995 CC(C)NC[C@@H](O)COc1cccc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H12 mock treatment 9.5244366E7 -6670000.0 -0.38 9.1895005E7 -8920000.0 -0.55 -0.6585 -0.984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H13 compound treatment 9.5693601E7 -6220000.0 -0.36 9.4590512E7 -6230000.0 -0.38 -0.5229 -0.9993 3903 SPBio_002996 CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H14 mock treatment 9.5802544E7 -6110000.0 -0.35 9.76108E7 -3210000.0 -0.2 -0.3868 -0.9636 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H15 compound treatment 7.2628596E7 -2.93E7 -1.67 7.4311691E7 -2.65E7 -1.63 -2.3389 -0.9999 1029881 SPBio_002997 CN1C2CCC1CC(O)C2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H16 mock treatment 8.7820954E7 -1.41E7 -0.81 8.8040558E7 -1.28E7 -0.79 -1.1265 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H17 compound treatment 9.8905248E7 -3010000.0 -0.17 9.8943839E7 -1870000.0 -0.12 -0.2033 -0.9812 954 SPBio_002998 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H18 mock treatment 9.7690748E7 -4230000.0 -0.24 9.8244095E7 -2570000.0 -0.16 -0.2829 -0.9792 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H19 compound treatment 3.4244527E7 -6.77E7 -3.87 3.4334608E7 -6.65E7 -4.1 -5.6326 -0.9996 1295 SPBio_002999 OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H20 mock treatment 9.7326945E7 -4590000.0 -0.26 9.3353764E7 -7460000.0 -0.46 -0.5108 -0.9645 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H21 compound treatment 5.2267356E7 -4.96E7 -2.84 5.3029996E7 -4.78E7 -2.95 -4.0894 -0.9998 3188278 SPBio_003000 COC(=O)Nc1nc2cc(SC(C)C)ccc2[nH]1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H22 mock treatment 9.7738883E7 -4180000.0 -0.24 8.978963E7 -1.1E7 -0.68 -0.6495 -0.9015 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H23 mock treatment 1.09472259E8 7560000.0 0.43 1.03345237E8 2530000.0 0.16 0.4155 0.9051 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 H24 mock treatment 1.08781455E8 6870000.0 0.39 1.0364313E8 2830000.0 0.17 0.4006 0.9332 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I01 mock treatment 1.15793101E8 1.39E7 0.79 1.12865786E8 1.2E7 0.74 1.086 0.9995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I02 mock treatment 1.15018615E8 1.31E7 0.75 1.11285203E8 1.05E7 0.65 0.9858 0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I03 compound treatment 1.16686389E8 1.48E7 0.84 1.15508743E8 1.47E7 0.91 1.2373 0.9994 3188016 SPBio_003001 CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(CN(C)C)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I04 compound treatment 1.13604088E8 1.17E7 0.67 1.10267718E8 9450000.0 0.58 0.8843 0.9977 3069781 SPBio_003002 CC(=O)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I05 compound treatment 1.18510232E8 1.66E7 0.95 1.1290642E8 1.21E7 0.75 1.1975 0.9929 3188017 SPBio_003003 S=C(NC1CCCCC1)N2CCC(CC2)C3C=NC=N3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I06 compound treatment 1.06908874E8 4990000.0 0.29 1.09477369E8 8660000.0 0.53 0.5792 0.9569 3177333 SPBio_003004 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I07 compound treatment 1.09494662E8 7580000.0 0.43 1.07243914E8 6430000.0 0.4 0.5864 0.999 3061617 SPBio_003005 OC(CNCCNC(=O)N1CCOCC1)COc2ccc(O)cc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I08 compound treatment 1.07269956E8 5350000.0 0.31 1.03333935E8 2520000.0 0.16 0.3261 0.9504 1053328 SPBio_003006 CCCC1C(=O)N2N(C1=O)c3cc(C)ccc3N=C2N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I09 compound treatment 8.5713729E7 -1.62E7 -0.93 8.4083671E7 -1.67E7 -1.03 -1.3842 -0.9985 1000092 SPBio_003007 COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I10 compound treatment 1.04558637E8 2640000.0 0.15 1.01015573E8 198000.0 0.01 0.1154 0.7618 3188033 SPBio_003008 CCC1(CCCCN(C)C1)c2cccc(O)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I11 compound treatment 4.3712278E7 -5.82E7 -3.33 4.228674E7 -5.85E7 -3.61 -4.9034 -0.9992 1007994 SPBio_003009 CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I12 compound treatment 9.8756491E7 -3160000.0 -0.18 9.8233504E7 -2580000.0 -0.16 -0.2403 -0.998 3188034 SPBio_003010 CNC1C(O)C2O[C@H](OC3C(N)C[C@@H](N)C(O)[C@H]3O)C(N)C[C@@H]2O[C@@H]1O[C@H]4OC(CO)[C@@H](N)[C@H](O)C4O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I13 compound treatment 7.4003639E7 -2.79E7 -1.6 7.3889023E7 -2.69E7 -1.66 -2.3018 -0.9998 3060036 SPBio_003011 C1CN=C(N1)C2COc3ccccc3O2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I14 compound treatment 1.00057836E8 -1860000.0 -0.11 9.9998481E7 -819000.0 -0.05 -0.1108 -0.9422 3069782 SPBio_003012 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4CC5SC5C[C@@]43C)[C@@H]2CC[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I15 compound treatment 1.03398045E8 1480000.0 0.08 1.04116882E8 3300000.0 0.2 0.2037 0.9246 3188018 SPBio_003013 CCN(CC)C(=O)N[C@@H]1CC2C(Cc3c[nH]c4cccc2c34)N(C)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I16 compound treatment 1.01382393E8 -534000.0 -0.03 1.0410821E8 3290000.0 0.2 0.1219 0.5941 3188035 SPBio_003014 C/C(=C(/CCO)\SSCC1CCCO1)/N(Cc2cnc(C)nc2N)C=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I17 compound treatment 1.01039412E8 -877000.0 -0.05 1.02318982E8 1500000.0 0.09 0.03 0.2853 1765 SPBio_003015 CC1(C)NC(=O)N(C1=O)c2ccc([N+](=O)[O-])c(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I18 compound treatment 1.01936847E8 20900.0 0.0 1.0185919E8 1040000.0 0.06 0.0462 0.7201 2080 SPBio_003016 CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I19 compound treatment 1.02844635E8 929000.0 0.05 9.9694954E7 -1120000.0 -0.07 -0.0114 -0.1307 3172846 SPBio_003017 NC(CO)(CO)CO.OC(=O)C1CCn2c(ccc12)C(=O)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I20 compound treatment 1.04744359E8 2830000.0 0.16 1.02890732E8 2070000.0 0.13 0.2047 0.9932 3188145 SPBio_003018 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I21 compound treatment 9.2836981E7 -9080000.0 -0.52 7.7271213E7 -2.35E7 -1.45 -1.3932 -0.9039 4487 SPBio_003019 CNCCCC1c2ccccc2C=Cc3ccccc13 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I22 compound treatment 9.3965239E7 -7950000.0 -0.45 9.0884707E7 -9930000.0 -0.61 -0.7543 -0.9892 3188146 SPBio_003020 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)OC4OC(=O)c5ccccc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I23 mock treatment 1.09029944E8 7110000.0 0.41 9.7322222E7 -3500000.0 -0.22 0.1351 0.2937 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 I24 mock treatment 1.06933445E8 5020000.0 0.29 1.14843263E8 1.4E7 0.86 0.8141 0.8938 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J01 mock treatment 1.11115253E8 9200000.0 0.53 1.08322255E8 7500000.0 0.46 0.6989 0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J02 mock treatment 1.15297001E8 1.34E7 0.76 1.11296954E8 1.05E7 0.65 0.9975 0.9965 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J03 compound treatment 1.09315713E8 7400000.0 0.42 1.00687159E8 -130000.0 -0.01 0.2934 0.6935 3002368 SPBio_003021 CC(C)NC[C@H](O)COc1cccc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J04 mock treatment 1.09627302E8 7710000.0 0.44 1.01543052E8 726000.0 0.04 0.3433 0.7749 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J05 compound treatment 2.9993442E7 -7.19E7 -4.11 2.9540871E7 -7.13E7 -4.39 -6.0134 -0.9994 907302 SPBio_003022 CN1CC[C@]2(C)C1N(C)c3ccc(O)cc32 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J06 mock treatment 1.06015586E8 4100000.0 0.23 1.02581693E8 1760000.0 0.11 0.2426 0.9391 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J07 compound treatment 9.6170115E7 -5750000.0 -0.33 9.3431936E7 -7390000.0 -0.46 -0.5541 -0.9871 3188279 SPBio_003023 CCN1C[C@]2(COC)CC[C@H](O)C3(C4C[C@H]5[C@H](OC(=O)C)C4[C@](O)(CC5OC)[C@H]6CC32)[C@@H]61 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J08 mock treatment 1.03890247E8 1970000.0 0.11 1.03551745E8 2730000.0 0.17 0.199 0.981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J09 compound treatment 1.0262939E8 713000.0 0.04 1.03010646E8 2190000.0 0.14 0.1244 0.8812 2060476 SPBio_003024 C[C@H]1[C@@H]2CCC(=C3[C@@H]([C@H]2OC1=O)C(=CC3=O)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J10 mock treatment 9.9302442E7 -2610000.0 -0.15 9.7899563E7 -2920000.0 -0.18 -0.2328 -0.9957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J11 compound treatment 9.8679937E7 -3240000.0 -0.18 9.7769498E7 -3050000.0 -0.19 -0.2636 -1.0 1336284 SPBio_003025 COc1c2CC(Oc2nc3ccccc13)C(C)(O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J12 mock treatment 9.8226603E7 -3690000.0 -0.21 9.6436229E7 -4380000.0 -0.27 -0.3401 -0.9925 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J13 compound treatment 9.7165168E7 -4750000.0 -0.27 9.8985533E7 -1830000.0 -0.11 -0.2718 -0.9244 3176921 SPBio_003026 N[C@H]1CONC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J14 mock treatment 9.6963523E7 -4950000.0 -0.28 9.8169633E7 -2650000.0 -0.16 -0.3156 -0.9658 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J15 compound treatment 9.6746259E7 -5170000.0 -0.3 1.00643712E8 -174000.0 -0.01 -0.2165 -0.7323 3069855 SPBio_003027 Clc1cnccn1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J16 mock treatment 9.7750299E7 -4170000.0 -0.24 1.01325507E8 508000.0 0.03 -0.1462 -0.6089 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J17 compound treatment 9.9554791E7 -2360000.0 -0.13 1.03909642E8 3090000.0 0.19 0.0394 0.1685 1076620 SPBio_003028 CNCC(O)c1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J18 mock treatment 9.7136992E7 -4780000.0 -0.27 9.8852518E7 -1960000.0 -0.12 -0.2788 -0.9331 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J19 compound treatment 9.501932E7 -6900000.0 -0.39 9.3009307E7 -7810000.0 -0.48 -0.6191 -0.9951 760 SPBio_003029 N[C@@H]1CONC1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J20 mock treatment 1.03807956E8 1890000.0 0.11 9.9018528E7 -1800000.0 -0.11 -0.002 -0.0126 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J21 compound treatment 9.742075E7 -4500000.0 -0.26 9.4126316E7 -6690000.0 -0.41 -0.4733 -0.974 1076027 SPBio_003030 CC1CC(CC(C)(C)C1)OC(=O)c2ccccc2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J22 mock treatment 1.02124356E8 208000.0 0.01 9.7780729E7 -3040000.0 -0.19 -0.1239 -0.6608 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J23 mock treatment 1.11998224E8 1.01E7 0.58 1.11694735E8 1.09E7 0.67 0.8816 0.9972 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 J24 mock treatment 1.10297437E8 8380000.0 0.48 1.04630623E8 3810000.0 0.24 0.5049 0.9463 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K01 mock treatment 1.06889752E8 4970000.0 0.28 1.07956227E8 7140000.0 0.44 0.5122 0.9776 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K02 mock treatment 9.8230006E7 -3690000.0 -0.21 9.6521601E7 -4300000.0 -0.26 -0.3362 -0.9936 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K03 compound treatment 9.2936234E7 -8980000.0 -0.51 1.03337647E8 2520000.0 0.16 -0.253 -0.4719 1677 SPBio_003031 CC(C)c1cccc(C(C)C)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K04 compound treatment 1.06431207E8 4520000.0 0.26 1.05163816E8 4350000.0 0.27 0.3719 0.9998 3188147 SPBio_003032 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)C(N3C2=O)C(=O)O)c4c(F)cccc4Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K05 compound treatment 9.2858327E7 -9060000.0 -0.52 8.9358443E7 -1.15E7 -0.71 -0.8655 -0.9883 3188019 SPBio_003033 CCN1CCCC1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K06 compound treatment 9.915553E7 -2760000.0 -0.16 9.8776467E7 -2040000.0 -0.13 -0.2005 -0.9937 2920 SPBio_003034 CCN(CC)c1cc(C)nc2ncnn12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K07 compound treatment 1.03889592E8 1970000.0 0.11 1.0254356E8 1730000.0 0.11 0.155 0.9996 962 SPBio_003035 CCC1(C(=O)NCNC1=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K08 compound treatment 8.343916E7 -1.85E7 -1.06 8.5626311E7 -1.52E7 -0.94 -1.4088 -0.9982 3188148 SPBio_003036 CN1C2CCC1CC(C2)OC3c4ccccc4CCc5ccccc35 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K09 compound treatment 9.4060666E7 -7860000.0 -0.45 9.5711992E7 -5110000.0 -0.31 -0.54 -0.9849 1910 SPBio_003037 Nc1nc(=O)[nH]cc1F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K10 compound treatment 8.5532889E7 -1.64E7 -0.94 7.8751918E7 -2.21E7 -1.36 -1.6239 -0.9834 3069806 SPBio_003038 OCCOCCOC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K11 compound treatment 9.5679866E7 -6240000.0 -0.36 9.35726E7 -7240000.0 -0.45 -0.5678 -0.9938 3069740 SPBio_003039 C[C@]1(N[C@H]2Cc3ccccc31)c4ccccc24 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K12 compound treatment 9.1278592E7 -1.06E7 -0.61 9.3248785E7 -7570000.0 -0.47 -0.7598 -0.9915 1022844 SPBio_003040 Oc1ccc(O)c(c1)S(=O)(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K13 compound treatment 8.9371845E7 -1.25E7 -0.72 9.2437311E7 -8380000.0 -0.52 -0.8722 -0.9871 3188020 SPBio_003041 C[N+](C)(CCCOc1ccccc1)c2ccccc2.OC(=O)c1cc2ccccc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K14 compound treatment 9.2162858E7 -9750000.0 -0.56 9.6834443E7 -3980000.0 -0.25 -0.5678 -0.9321 1779 SPBio_003042 COc1nc(C)nc(Cl)c1NC2=NCCN2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K15 compound treatment 9.4708881E7 -7210000.0 -0.41 9.9694962E7 -1120000.0 -0.07 -0.3402 -0.8145 3069741 SPBio_003043 CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CCC4=O)[C@@H]3CC=C2C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K16 compound treatment 9.3750321E7 -8170000.0 -0.47 9.8928498E7 -1890000.0 -0.12 -0.4123 -0.8573 1326779 SPBio_003044 CCNCC(O)c1cccc(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K17 compound treatment 5.434731E7 -4.76E7 -2.72 6.8111605E7 -3.27E7 -2.02 -3.3479 -0.9892 1095 SPBio_003045 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K18 compound treatment 7.8793218E7 -2.31E7 -1.32 8.1904045E7 -1.89E7 -1.17 -1.7588 -0.998 220 SPBio_003046 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K19 compound treatment 9.636826E7 -5550000.0 -0.32 9.5571052E7 -5250000.0 -0.32 -0.4529 -1.0 2685 SPBio_003047 OC(=O)c1c(I)cc(I)c(NC(=O)CCCCC(=O)Nc2c(I)cc(I)c(C(=O)O)c2I)c1I 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K20 compound treatment 9.8714846E7 -3200000.0 -0.18 9.2143659E7 -8670000.0 -0.53 -0.5074 -0.8979 3188149 SPBio_003048 CCO[C@@H]1O[C@H](C(COCc2ccccc2)OCc3ccccc3)[C@@H](OCc4ccccc4)C1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K21 compound treatment 5.7871742E7 -4.4E7 -2.52 6.0123571E7 -4.07E7 -2.51 -3.5537 -1.0 1020463 SPBio_003049 Oc1cc2ccc(=O)oc2cc1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K22 compound treatment 4.6189655E7 -5.57E7 -3.18 4.3068853E7 -5.77E7 -3.56 -4.7692 -0.9985 3188150 SPBio_003050 CCC(=O)[C@@]1(C)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K23 mock treatment 1.00944784E8 -971000.0 -0.06 9.174023E7 -9080000.0 -0.56 -0.4349 -0.7735 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 K24 mock treatment 1.09795858E8 7880000.0 0.45 1.05219514E8 4400000.0 0.27 0.5103 0.9706 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L01 mock treatment 1.06008574E8 4090000.0 0.23 1.00922027E8 105000.0 0.01 0.1699 0.7263 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L02 mock treatment 9.4781823E7 -7130000.0 -0.41 9.7659978E7 -3160000.0 -0.19 -0.4259 -0.9427 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L03 compound treatment 1.09546506E8 7630000.0 0.44 1.06391066E8 5570000.0 0.34 0.5513 0.993 1269 SPBio_003051 CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L04 mock treatment 9.7370492E7 -4550000.0 -0.26 9.7808947E7 -3010000.0 -0.19 -0.3148 -0.9864 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L05 compound treatment 1.00687994E8 -1230000.0 -0.07 9.8148247E7 -2670000.0 -0.16 -0.166 -0.9278 3069858 SPBio_003052 Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(=O)(O)O[C@@H]4C3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L06 mock treatment 9.9566151E7 -2350000.0 -0.13 9.7421285E7 -3400000.0 -0.21 -0.243 -0.977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L07 compound treatment 1.03229345E8 1310000.0 0.08 1.00457097E8 -360000.0 -0.02 0.0374 0.4774 907479 SPBio_003053 CCCN1CCC[C@@H]2Cc3n[nH]cc3C[C@H]21 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L08 mock treatment 1.01778028E8 -138000.0 -0.01 1.01160313E8 343000.0 0.02 0.0094 0.4153 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L09 compound treatment 9.6305607E7 -5610000.0 -0.32 9.8952734E7 -1860000.0 -0.11 -0.308 -0.9042 3188280 SPBio_003054 COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L10 mock treatment 9.480093E7 -7120000.0 -0.41 9.7822652E7 -2990000.0 -0.18 -0.4181 -0.9362 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L11 compound treatment 9.0250107E7 -1.17E7 -0.67 9.2820771E7 -8000000.0 -0.49 -0.82 -0.989 1221 SPBio_003055 CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L12 mock treatment 9.1168602E7 -1.07E7 -0.61 9.2560262E7 -8260000.0 -0.51 -0.7942 -0.9956 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L13 compound treatment 8.613983E7 -1.58E7 -0.9 8.4424668E7 -1.64E7 -1.01 -1.3521 -0.9984 3188281 SPBio_003056 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2C[C@@H](O)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L14 mock treatment 8.7937905E7 -1.4E7 -0.8 9.323934E7 -7580000.0 -0.47 -0.8952 -0.9673 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L15 compound treatment 8.4726267E7 -1.72E7 -0.98 8.5399855E7 -1.54E7 -0.95 -1.3667 -0.9999 1479 SPBio_003057 CC(C)NCC(O)c1ccc(O)c(O)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L16 mock treatment 9.039723E7 -1.15E7 -0.66 9.5624418E7 -5190000.0 -0.32 -0.6919 -0.9451 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L17 compound treatment 7.5703217E7 -2.62E7 -1.5 8.4382879E7 -1.64E7 -1.01 -1.7757 -0.9819 2121 SPBio_003058 Oc1ccc(cc1)c2oc3cc(O)cc(O)c3c(=O)c2O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L18 mock treatment 9.5800142E7 -6120000.0 -0.35 9.5826206E7 -4990000.0 -0.31 -0.4647 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L19 compound treatment 9.7840636E7 -4080000.0 -0.23 1.021178E8 1300000.0 0.08 -0.108 -0.4385 865102 SPBio_003059 O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L20 mock treatment 9.9925609E7 -1990000.0 -0.11 1.02942618E8 2130000.0 0.13 0.0122 0.0703 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L21 compound treatment 8.8571773E7 -1.33E7 -0.76 8.1040175E7 -1.98E7 -1.22 -1.4013 -0.9745 3188282 SPBio_003060 CC1C(C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)C(=O)c2ccccc2C1=O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L22 mock treatment 9.0843908E7 -1.11E7 -0.63 9.1372888E7 -9440000.0 -0.58 -0.8591 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L23 mock treatment 1.00407375E8 -1510000.0 -0.09 9.3081587E7 -7740000.0 -0.48 -0.3982 -0.8216 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 L24 mock treatment 1.12517222E8 1.06E7 0.61 1.03957621E8 3140000.0 0.19 0.5653 0.8888 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M01 mock treatment 1.20874078E8 1.9E7 1.08 1.20634072E8 1.98E7 1.22 1.6299 0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M02 mock treatment 1.13319206E8 1.14E7 0.65 1.01582339E8 765000.0 0.05 0.4942 0.7563 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M03 compound treatment 1.00272021E8 -1640000.0 -0.09 9.7776405E7 -3040000.0 -0.19 -0.199 -0.949 2030 SPBio_003061 OC(=O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M04 compound treatment 1.03694787E8 1780000.0 0.1 9.9549231E7 -1270000.0 -0.08 0.0166 0.1295 3480040 SPBio_003062 COC(=O)C1=C(C)NC(=C(C1c2cccc3nonc23)C(=O)OC(C)C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M05 compound treatment 9.5990497E7 -5930000.0 -0.34 9.3095959E7 -7720000.0 -0.48 -0.576 -0.9861 907192 SPBio_003063 CC[N+](C)(C)Cc1ccccc1Br 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M06 compound treatment 9.4916473E7 -7000000.0 -0.4 9.5044369E7 -5770000.0 -0.36 -0.5345 -0.9983 1077199 SPBio_003064 CCNC1(CCCCC1=O)c2cccs2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M07 compound treatment 9.352348E7 -8390000.0 -0.48 9.6456378E7 -4360000.0 -0.27 -0.5293 -0.9625 3172714 SPBio_003065 C[n+]1ccccc1/C=N/O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M08 compound treatment 9.5760778E7 -6160000.0 -0.35 9.7448298E7 -3370000.0 -0.21 -0.3956 -0.9684 3069807 SPBio_003066 CNC(C)CCC=C(C)C.OC(C(O)C(O)C(=O)O)C(O)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M09 compound treatment 4.5862575E7 -5.61E7 -3.2 4.8368648E7 -5.24E7 -3.23 -4.5514 -1.0 1395 SPBio_003067 CC(COc1ccccc1)N(CCCl)Cc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M10 compound treatment 9.0515607E7 -1.14E7 -0.65 9.4332221E7 -6490000.0 -0.4 -0.7434 -0.9725 3188151 SPBio_003068 CC1CS(=O)(=O)CCN1/N=C/c2ccc(o2)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M11 compound treatment 9.0286316E7 -1.16E7 -0.66 9.1134985E7 -9680000.0 -0.6 -0.892 -0.9986 2844 SPBio_003069 CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M12 compound treatment 8.9805596E7 -1.21E7 -0.69 8.660317E7 -1.42E7 -0.88 -1.109 -0.9932 1698 SPBio_003070 N#Cc1ccc(cc1)C(c2ccc(C#N)cc2)n3cncn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M13 compound treatment 8.6609496E7 -1.53E7 -0.87 8.9130597E7 -1.17E7 -0.72 -1.128 -0.9953 1371 SPBio_003071 CN(C)c1nc(nc(n1)N(C)C)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M14 compound treatment 8.7267821E7 -1.46E7 -0.84 8.6785907E7 -1.4E7 -0.86 -1.2036 -0.9999 4425 SPBio_003072 CC(C)NCC1CCc2cc(CO)c(cc2N1)[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M15 compound treatment 3.8615385E7 -6.33E7 -3.62 4.140425E7 -5.94E7 -3.66 -5.1478 -1.0 349 SPBio_003073 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M16 compound treatment 8.5768258E7 -1.61E7 -0.92 8.9762711E7 -1.11E7 -0.68 -1.1344 -0.9889 3188152 SPBio_003074 CC(N)C(=O)Nc1c(C)cccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M17 compound treatment 8.8351272E7 -1.36E7 -0.78 8.8776565E7 -1.2E7 -0.74 -1.073 -0.9998 1428570 SPBio_003075 CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M18 compound treatment 9.2511826E7 -9400000.0 -0.54 9.2192138E7 -8630000.0 -0.53 -0.756 -1.0 3188153 SPBio_003076 CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2C1C(=O)O.C(CNCc1ccccc1)NCc2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M19 compound treatment 9.5448399E7 -6470000.0 -0.37 9.8098811E7 -2720000.0 -0.17 -0.3799 -0.936 893 SPBio_003077 NCC(O)c1ccc(O)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M20 compound treatment 9.2564911E7 -9350000.0 -0.53 9.0439555E7 -1.04E7 -0.64 -0.8303 -0.996 1795 SPBio_003078 Cc1nc2CCCCn2c(=O)c1CCN3CCC(CC3)c4noc5cc(F)ccc45 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M21 compound treatment 9.2208276E7 -9710000.0 -0.55 1.01620971E8 803000.0 0.05 -0.3573 -0.6414 806 SPBio_003079 OC(=O)C1CCCNC1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M22 compound treatment 9.8097433E7 -3820000.0 -0.22 9.4489085E7 -6330000.0 -0.39 -0.4302 -0.9623 1001638 SPBio_003080 CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M23 mock treatment 1.02154305E8 238000.0 0.01 9.1876355E7 -8940000.0 -0.55 -0.3801 -0.6894 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 M24 mock treatment 1.08962538E8 7050000.0 0.4 1.08718777E8 7900000.0 0.49 0.6292 0.9955 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N01 mock treatment 1.13509572E8 1.16E7 0.66 1.07442663E8 6630000.0 0.41 0.7573 0.973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N02 mock treatment 1.12008273E8 1.01E7 0.58 1.10121892E8 9300000.0 0.57 0.8134 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N03 compound treatment 6.8950004E7 -3.3E7 -1.88 4.004061E7 -6.08E7 -3.75 -3.9814 -0.9494 3487604 SPBio_003081 CCNC1CC(N)C(OC2OC(=CCC2N)CN)C(O)C1OC3OCC(C)(O)C(NC)C3O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N04 mock treatment 1.02599083E8 683000.0 0.04 1.01971181E8 1150000.0 0.07 0.0779 0.9601 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N05 compound treatment 9.9590026E7 -2330000.0 -0.13 9.8172214E7 -2650000.0 -0.16 -0.2093 -0.9949 3173761 SPBio_003082 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N06 mock treatment 9.4024286E7 -7890000.0 -0.45 9.4435901E7 -6380000.0 -0.39 -0.5971 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N07 compound treatment 8.8713393E7 -1.32E7 -0.75 9.2012779E7 -8800000.0 -0.54 -0.9173 -0.9869 1111897 SPBio_003083 COc1ccc2nccc(C(=O)O)c2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N08 mock treatment 9.0814224E7 -1.11E7 -0.63 9.2382904E7 -8430000.0 -0.52 -0.8163 -0.9951 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N09 compound treatment 8.9814128E7 -1.21E7 -0.69 9.3641052E7 -7180000.0 -0.44 -0.8019 -0.9767 3188283 SPBio_003084 CC1O[C@@H](OC/2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(=O)O)C[C@@H](O)C[C@H]4O[C@@H]4\C=C\C(=O)O[C@H](C)C\C=C\C=C\C=C\C=C2)C(O)C(N)[C@@H]1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N10 mock treatment 8.7776673E7 -1.41E7 -0.81 9.3690704E7 -7130000.0 -0.44 -0.882 -0.959 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N11 compound treatment 8.1174266E7 -2.07E7 -1.19 7.8991205E7 -2.18E7 -1.35 -1.7896 -0.998 3188284 SPBio_003085 COC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5C)[C@]6(C)C(C(=O)OC)C(=CC=C46)C(=O)OC)c(C)c3C=C.COC(=O)CCc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)c(CCC(=O)O)c5C)c(C=C)c4C)C6=CC=C(C(C(=O)OC)[C@]63C)C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N12 mock treatment 8.6657497E7 -1.53E7 -0.87 8.9485038E7 -1.13E7 -0.7 -1.1106 -0.994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N13 compound treatment 8.1767677E7 -2.01E7 -1.15 8.7159691E7 -1.37E7 -0.84 -1.4096 -0.9882 1000348 SPBio_003086 C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(=O)O)S[C@@H]3CN[C@@H](C3)C(=O)N(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N14 mock treatment 8.2857467E7 -1.91E7 -1.09 8.8113106E7 -1.27E7 -0.78 -1.324 -0.9869 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N15 compound treatment 7.7045778E7 -2.49E7 -1.42 8.4100689E7 -1.67E7 -1.03 -1.7337 -0.9875 3069861 SPBio_003087 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2C(C[C@@H]3CCC[C@@H]32)C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N16 mock treatment 8.4767355E7 -1.71E7 -0.98 8.9739082E7 -1.11E7 -0.68 -1.1759 -0.9844 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N17 compound treatment 8.7398065E7 -1.45E7 -0.83 9.5563483E7 -5250000.0 -0.32 -0.8157 -0.9158 1517 SPBio_003088 CCC1(NC(=O)N(C)C1=O)c2ccccc2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N18 mock treatment 8.0584464E7 -2.13E7 -1.22 9.0942589E7 -9870000.0 -0.61 -1.2925 -0.9485 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N19 compound treatment 9.013275E7 -1.18E7 -0.67 9.138606E7 -9430000.0 -0.58 -0.8873 -0.9973 3188285 SPBio_003089 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4C5=NC6(CCN(CC(C)C)CC6)NC5=C(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)C(=O)c4c(O)c3C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N20 mock treatment 9.4995074E7 -6920000.0 -0.4 1.01284294E8 467000.0 0.03 -0.2593 -0.6539 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N21 compound treatment 4.0434454E7 -6.15E7 -3.51 4.1581504E7 -5.92E7 -3.65 -5.0666 -0.9998 3069862 SPBio_003090 CCCCc1ccc2[nH]c(NC(=O)OC)nc2c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N22 mock treatment 9.4509274E7 -7410000.0 -0.42 9.0353111E7 -1.05E7 -0.65 -0.7554 -0.9791 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N23 mock treatment 9.680152E7 -5110000.0 -0.29 9.1071082E7 -9750000.0 -0.6 -0.6315 -0.9452 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 N24 mock treatment 1.02360662E8 445000.0 0.03 1.08427103E8 7610000.0 0.47 0.3497 0.7443 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O01 mock treatment 1.15140808E8 1.32E7 0.76 1.12023331E8 1.12E7 0.69 1.0229 0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O02 mock treatment 1.010924E8 -824000.0 -0.05 1.03042192E8 2220000.0 0.14 0.0637 0.4393 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O03 compound treatment 9.3861823E7 -8050000.0 -0.46 7.8872855E7 -2.19E7 -1.35 -1.282 -0.8972 2660 SPBio_003091 CCN(C(=O)/C=C/C)c1ccccc1C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O04 compound treatment 9.2005783E7 -9910000.0 -0.57 9.5802726E7 -5010000.0 -0.31 -0.6191 -0.9594 2080909 SPBio_003092 CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O05 compound treatment 9.5105703E7 -6810000.0 -0.39 9.766981E7 -3150000.0 -0.19 -0.4124 -0.9483 351 SPBio_003093 CC(C)NCC(O)COc1cccc2ccccc12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O06 compound treatment 9.6784384E7 -5130000.0 -0.29 1.0010962E8 -708000.0 -0.04 -0.2382 -0.8035 3069809 SPBio_003094 CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O07 compound treatment 9.3105518E7 -8810000.0 -0.5 9.3771291E7 -7050000.0 -0.43 -0.6632 -0.9973 1001857 SPBio_003095 CC(C)NC[C@@H](O)COc1ccc(CC(=O)N)cc1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O08 compound treatment 9.1982605E7 -9930000.0 -0.57 9.5358848E7 -5460000.0 -0.34 -0.6394 -0.9688 3188154 SPBio_003096 CC(=O)CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O09 compound treatment 9.4407176E7 -7510000.0 -0.43 1.00272993E8 -544000.0 -0.03 -0.3272 -0.7601 3188022 SPBio_003097 CC(C)(C)CC(C)(C)c1ccc(OCOCCOCCO)c(Cc2cc(cc(Cc3cc(ccc3OCOCCOCCO)C(C)(C)CC(C)(C)C)c2OCOCCOCCO)C(C)(C)CC(C)(C)C)c1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O10 compound treatment 8.6702391E7 -1.52E7 -0.87 9.656588E7 -4250000.0 -0.26 -0.8001 -0.8811 3177327 SPBio_003098 CC(=O)O[C@H]1[C@H](C[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C)[C@H](C[C@]4(C)[C@H]3CC[C@]12C)[N+]5(C)CCCCC5)[N+]6(C)CCCCC6 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O11 compound treatment 9.3407442E7 -8510000.0 -0.49 9.5131471E7 -5690000.0 -0.35 -0.5917 -0.9871 3069742 SPBio_003099 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O12 compound treatment 9.2179262E7 -9740000.0 -0.56 9.2652249E7 -8170000.0 -0.5 -0.7494 -0.9987 1511611 SPBio_003100 CCc1c(C)[nH]c2CCC(CN3CCOCC3)C(=O)c12 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O13 compound treatment 7.4185673E7 -2.77E7 -1.58 7.7706268E7 -2.31E7 -1.42 -2.128 -0.9986 4369 SPBio_003101 CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O14 compound treatment 7.8800431E7 -2.31E7 -1.32 8.9242061E7 -1.16E7 -0.71 -1.4387 -0.9582 3188155 SPBio_003102 OC/C=C\1/[C@@H]2C[C@@H]3[C@@H](CC[C@]34C5N(C=C6C7N(C=C52)c8ccccc8[C@]97CC[C@@H]%10[C@H]9C[C@H]6\C(=C\CO)\N%10CC=C)c%11ccccc%114)N1CC=C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O15 compound treatment 7.6584572E7 -2.53E7 -1.45 8.3900789E7 -1.69E7 -1.04 -1.7611 -0.987 3069771 SPBio_003103 C[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O16 compound treatment 6.8431579E7 -3.35E7 -1.91 8.2874389E7 -1.79E7 -1.11 -2.1353 -0.966 2747 SPBio_003104 Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O17 compound treatment 8.8725044E7 -1.32E7 -0.75 9.6921601E7 -3900000.0 -0.24 -0.7029 -0.8884 1000212 SPBio_003105 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O18 compound treatment 7.2296808E7 -2.96E7 -1.69 8.1973087E7 -1.88E7 -1.16 -2.0184 -0.9831 3069810 SPBio_003106 COc1ccc(C[C@](C)(N)C(=O)O)cc1OC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O19 compound treatment 9.5826005E7 -6090000.0 -0.35 1.05393715E8 4580000.0 0.28 -0.0466 -0.1041 4481 SPBio_003107 CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O20 compound treatment 8.6634397E7 -1.53E7 -0.87 8.569836E7 -1.51E7 -0.93 -1.2766 -0.9995 3069811 SPBio_003108 C[C@@H]1CN(CC[C@]1(C(=O)O)c2ccccc2)[C@H]3CC[C@](CC3)(C#N)c4ccc(F)cc4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O21 compound treatment 1.02272694E8 357000.0 0.02 1.03886119E8 3070000.0 0.19 0.1482 0.7788 1167 SPBio_003109 NCCCCCC(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O22 compound treatment 3.017748E7 -7.17E7 -4.1 3.1534592E7 -6.93E7 -4.27 -5.919 -0.9998 3188156 SPBio_003110 CN(C)c1ccc2[n+](C)c(/C=C\c3cc(C)n(c3C)c4ccccc4)ccc2c1.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O23 mock treatment 9.4770376E7 -7150000.0 -0.41 9.7990764E7 -2830000.0 -0.17 -0.412 -0.9279 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 O24 mock treatment 1.07463957E8 5550000.0 0.32 1.15104824E8 1.43E7 0.88 0.847 0.9048 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P01 mock treatment 1.16377909E8 1.45E7 0.83 1.157464E8 1.49E7 0.92 1.2352 0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P02 mock treatment 1.1228546E8 1.04E7 0.59 1.10285184E8 9470000.0 0.58 0.8317 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P03 compound treatment 9.8924753E7 -2990000.0 -0.17 1.1027367E8 9460000.0 0.58 0.2913 0.4795 3856 SPBio_003111 CNC1(C)C2CCC(C2)C1(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P04 mock treatment 1.01191553E8 -724000.0 -0.04 1.06103046E8 5290000.0 0.33 0.2011 0.6123 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P05 compound treatment 1.00971124E8 -945000.0 -0.05 1.00854403E8 36900.0 0.0 -0.0366 -0.6767 3199 SPBio_003112 CNNCc1ccc(cc1)C(=O)NC(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P06 mock treatment 9.9561772E7 -2350000.0 -0.13 1.02289943E8 1470000.0 0.09 -0.031 -0.1907 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P07 compound treatment 9.9605071E7 -2310000.0 -0.13 1.00682908E8 -135000.0 -0.01 -0.0993 -0.75 3188286 SPBio_003113 NCCCC(N)CC(=O)NC1CNC(=O)C(NC(=O)/C(=C/NC(=O)N)/NC(=O)C(CO)NC(=O)C(CO)NC1=O)C2CC(O)N=C(N)N2 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P08 mock treatment 8.9764228E7 -1.22E7 -0.69 8.9597437E7 -1.12E7 -0.69 -0.9801 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P09 compound treatment 8.6082118E7 -1.58E7 -0.9 9.517761E7 -5640000.0 -0.35 -0.8857 -0.9137 3069863 SPBio_003114 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)N)NC(=O)c4ccc5ccccc5n4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P10 mock treatment 8.7585466E7 -1.43E7 -0.82 9.3393952E7 -7420000.0 -0.46 -0.9027 -0.9622 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P11 compound treatment 8.5230127E7 -1.67E7 -0.95 9.2064841E7 -8750000.0 -0.54 -1.0558 -0.9636 1509 SPBio_003115 Cn1c(COC(=O)N)ncc1[N+](=O)[O-] 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P12 mock treatment 8.910769E7 -1.28E7 -0.73 8.736049E7 -1.35E7 -0.83 -1.1042 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P13 compound treatment 8.2315528E7 -1.96E7 -1.12 8.7235415E7 -1.36E7 -0.84 -1.3841 -0.9897 1829 SPBio_003116 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(=O)(=O)N 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P14 mock treatment 7.6389015E7 -2.55E7 -1.46 8.205426E7 -1.88E7 -1.16 -1.8495 -0.9934 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P15 compound treatment 8.2184583E7 -1.97E7 -1.13 9.203458E7 -8780000.0 -0.54 -1.1802 -0.9435 1078453 SPBio_003117 Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P16 mock treatment 7.8084137E7 -2.38E7 -1.36 8.7867496E7 -1.29E7 -0.8 -1.5276 -0.9676 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P17 compound treatment 8.7582665E7 -1.43E7 -0.82 1.00579754E8 -238000.0 -0.01 -0.5896 -0.7196 3188288 SPBio_003118 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C[N+]3(C)CCCC3)\c4csc(N)n4 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P18 mock treatment 8.9450978E7 -1.25E7 -0.71 9.4617069E7 -6200000.0 -0.38 -0.774 -0.9574 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P19 compound treatment 3.6135412E7 -6.58E7 -3.76 3.6655272E7 -6.42E7 -3.96 -5.455 -0.9997 3188289 SPBio_003119 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P20 mock treatment 9.0787305E7 -1.11E7 -0.64 9.756553E7 -3250000.0 -0.2 -0.5915 -0.887 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P21 compound treatment 9.4068029E7 -7850000.0 -0.45 9.8662748E7 -2150000.0 -0.13 -0.4111 -0.8788 2884 SPBio_003120 CC1(C)S[C@@H]2[C@H](NC(=O)C3(N)CCCCC3)C(=O)N2[C@H]1C(=O)O 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P22 mock treatment 9.9594236E7 -2320000.0 -0.13 9.9683686E7 -1130000.0 -0.07 -0.1432 -0.9552 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P23 mock treatment 1.0670089E8 4780000.0 0.27 1.08737825E8 7920000.0 0.49 0.5386 0.9625 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.2167 P24 mock treatment 1.08672587E8 6760000.0 0.39 1.13538918E8 1.27E7 0.78 0.8276 0.9467 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A01 positive control 4.3428634E7 -5.78E7 -3.3 4.1778022E7 -4.7E7 -2.9 -4.3841 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A02 positive control 4.0655359E7 -6.06E7 -3.46 3.875281E7 -5.0E7 -3.08 -4.628 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A03 positive control 3.9981882E7 -6.12E7 -3.5 3.8064263E7 -5.07E7 -3.13 -4.6853 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A04 positive control 4.1935052E7 -5.93E7 -3.39 4.1413529E7 -4.74E7 -2.92 -4.4603 -0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A05 positive control 3.7243959E7 -6.4E7 -3.66 3.6869526E7 -5.19E7 -3.2 -4.848 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A06 positive control 3.3152937E7 -6.81E7 -3.89 3.5739059E7 -5.3E7 -3.27 -5.0626 -0.9963 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A07 positive control 3.561787E7 -6.56E7 -3.75 3.5729826E7 -5.31E7 -3.27 -4.9634 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A08 positive control 3.5587553E7 -6.56E7 -3.75 3.5351621E7 -5.34E7 -3.29 -4.9811 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A09 positive control 3.5890193E7 -6.53E7 -3.73 3.646166E7 -5.23E7 -3.23 -4.9205 -0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A10 positive control 3.6454496E7 -6.48E7 -3.7 3.631402E7 -5.25E7 -3.23 -4.9041 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A11 positive control 3.707156E7 -6.41E7 -3.67 3.6472183E7 -5.23E7 -3.22 -4.8723 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A12 positive control 3.7070564E7 -6.41E7 -3.67 3.67053E7 -5.21E7 -3.21 -4.8622 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A13 mock treatment 8.1810655E7 -1.94E7 -1.11 1.04105339E8 1.53E7 0.94 -0.1163 -0.0798 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A14 mock treatment 9.3896499E7 -7320000.0 -0.42 9.7982395E7 9200000.0 0.57 0.1052 0.1493 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A15 mock treatment 9.2184342E7 -9030000.0 -0.52 9.5053125E7 6270000.0 0.39 -0.0916 -0.1421 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A16 mock treatment 9.1519052E7 -9700000.0 -0.55 9.8698511E7 9920000.0 0.61 0.0404 0.0489 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A17 mock treatment 9.6705871E7 -4510000.0 -0.26 9.9484637E7 1.07E7 0.66 0.2843 0.4013 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A18 mock treatment 1.02251032E8 1030000.0 0.06 1.10180339E8 2.14E7 1.32 0.9746 0.7381 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A19 mock treatment 1.00459877E8 -756000.0 -0.04 1.0268587E8 1.39E7 0.86 0.5755 0.6706 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A20 mock treatment 1.02827571E8 1610000.0 0.09 1.06055439E8 1.73E7 1.06 0.8181 0.7654 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A21 mock treatment 1.09730863E8 8510000.0 0.49 1.04941143E8 1.62E7 1.0 1.0485 0.9457 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A22 mock treatment 1.08262064E8 7050000.0 0.4 1.10554319E8 2.18E7 1.34 1.2338 0.8805 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A23 mock treatment 1.16600486E8 1.54E7 0.88 1.14410456E8 2.56E7 1.58 1.7388 0.9617 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon A24 mock treatment 1.22508324E8 2.13E7 1.22 1.08394289E8 1.96E7 1.21 1.7154 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B01 positive control 4.3246427E7 -5.8E7 -3.31 4.2616158E7 -4.62E7 -2.85 -4.3549 -0.9971 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B02 positive control 3.7649022E7 -6.36E7 -3.63 3.7819346E7 -5.1E7 -3.14 -4.7902 -0.9974 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B03 positive control 3.5772453E7 -6.54E7 -3.74 3.6006653E7 -5.28E7 -3.25 -4.9451 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B04 positive control 3.5481596E7 -6.57E7 -3.76 3.4696946E7 -5.41E7 -3.33 -5.0139 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B05 positive control 3.5676182E7 -6.55E7 -3.75 3.4026927E7 -5.48E7 -3.38 -5.0352 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B06 positive control 3.5681713E7 -6.55E7 -3.75 3.4621066E7 -5.42E7 -3.34 -5.0091 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B07 positive control 3.572128E7 -6.55E7 -3.74 3.3898849E7 -5.49E7 -3.38 -5.039 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B08 positive control 3.334868E7 -6.79E7 -3.88 3.5103385E7 -5.37E7 -3.31 -5.0824 -0.9969 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B09 positive control 3.3261835E7 -6.8E7 -3.88 3.3967292E7 -5.48E7 -3.38 -5.1354 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B10 positive control 3.2738753E7 -6.85E7 -3.91 3.4848559E7 -5.39E7 -3.32 -5.1181 -0.9967 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B11 positive control 3.2782251E7 -6.84E7 -3.91 3.3750393E7 -5.5E7 -3.39 -5.1643 -0.9975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B12 positive control 3.3177855E7 -6.8E7 -3.89 3.4087895E7 -5.47E7 -3.37 -5.1336 -0.9975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B13 mock treatment 7.8857108E7 -2.24E7 -1.28 9.1012247E7 2230000.0 0.14 -0.8063 -0.6274 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B14 mock treatment 8.0804565E7 -2.04E7 -1.17 9.0236822E7 1460000.0 0.09 -0.7614 -0.6508 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B15 mock treatment 8.9361978E7 -1.19E7 -0.68 9.1064431E7 2280000.0 0.14 -0.3795 -0.5485 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B16 mock treatment 8.492731E7 -1.63E7 -0.93 8.9807048E7 1030000.0 0.06 -0.6136 -0.6576 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B17 mock treatment 8.8669095E7 -1.25E7 -0.72 9.5833466E7 7050000.0 0.43 -0.1997 -0.2381 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B18 mock treatment 9.0517543E7 -1.07E7 -0.61 9.3491161E7 4710000.0 0.29 -0.2271 -0.3355 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B19 mock treatment 9.4920113E7 -6300000.0 -0.36 9.6128381E7 7350000.0 0.45 0.0658 0.1138 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B20 mock treatment 1.05301846E8 4090000.0 0.23 1.03524569E8 1.47E7 0.91 0.8077 0.8608 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B21 mock treatment 9.5855075E7 -5360000.0 -0.31 9.9539505E7 1.08E7 0.66 0.2523 0.3453 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B22 mock treatment 1.0271611E8 1500000.0 0.09 9.7911581E7 9130000.0 0.56 0.4586 0.8055 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B23 mock treatment 1.04323552E8 3110000.0 0.18 9.4776856E7 6000000.0 0.37 0.3869 0.9436 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon B24 mock treatment 1.21552662E8 2.03E7 1.16 1.14498557E8 2.57E7 1.59 1.9428 0.9884 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C01 positive control 4.1590191E7 -5.96E7 -3.41 3.909376E7 -4.97E7 -3.06 -4.5754 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C02 positive control 3.7209839E7 -6.4E7 -3.66 3.6988853E7 -5.18E7 -3.19 -4.8442 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C03 positive control 3.7178387E7 -6.4E7 -3.66 3.5679717E7 -5.31E7 -3.27 -4.9025 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C04 positive control 3.5662261E7 -6.56E7 -3.75 3.5134361E7 -5.36E7 -3.31 -4.9875 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C05 positive control 3.7774207E7 -6.34E7 -3.63 3.5093353E7 -5.37E7 -3.31 -4.904 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C06 positive control 3.4125987E7 -6.71E7 -3.83 3.3620421E7 -5.52E7 -3.4 -5.1156 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C07 positive control 3.6694196E7 -6.45E7 -3.69 3.5741494E7 -5.3E7 -3.27 -4.9194 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C08 positive control 3.5019927E7 -6.62E7 -3.78 3.5181551E7 -5.36E7 -3.3 -5.0114 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C09 positive control 3.5277003E7 -6.59E7 -3.77 3.4340296E7 -5.44E7 -3.36 -5.0377 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C10 positive control 3.4380843E7 -6.68E7 -3.82 3.4984812E7 -5.38E7 -3.32 -5.0458 -0.9975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C11 positive control 3.5029754E7 -6.62E7 -3.78 3.4301713E7 -5.45E7 -3.36 -5.0494 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C12 positive control 3.5742832E7 -6.55E7 -3.74 3.4352716E7 -5.44E7 -3.36 -5.0184 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C13 mock treatment 8.3409548E7 -1.78E7 -1.02 8.622268E7 -2560000.0 -0.16 -0.8311 -0.8071 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C14 mock treatment 8.7569409E7 -1.36E7 -0.78 8.2973476E7 -5810000.0 -0.36 -0.8046 -0.9376 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C15 mock treatment 8.5606817E7 -1.56E7 -0.89 8.7156156E7 -1630000.0 -0.1 -0.7016 -0.7816 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C16 mock treatment 9.0384378E7 -1.08E7 -0.62 8.7356242E7 -1420000.0 -0.09 -0.4999 -0.7994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C17 mock treatment 8.9499551E7 -1.17E7 -0.67 8.9192805E7 412000.0 0.03 -0.4556 -0.6798 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C18 mock treatment 9.1986452E7 -9230000.0 -0.53 8.7968862E7 -812000.0 -0.05 -0.4084 -0.7708 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C19 mock treatment 9.3646924E7 -7570000.0 -0.43 8.727884E7 -1500000.0 -0.09 -0.3714 -0.8395 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C20 mock treatment 9.7876877E7 -3340000.0 -0.19 9.0911274E7 2130000.0 0.13 -0.0421 -0.1818 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C21 mock treatment 1.02545341E8 1330000.0 0.08 8.9802934E7 1020000.0 0.06 0.0982 0.9957 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C22 mock treatment 1.00968534E8 -248000.0 -0.01 9.5022617E7 6240000.0 0.38 0.262 0.6806 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C23 mock treatment 1.0405589E8 2840000.0 0.16 8.9573587E7 792000.0 0.05 0.1493 0.8809 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon C24 mock treatment 1.21534706E8 2.03E7 1.16 1.09298886E8 2.05E7 1.26 1.7154 0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D01 positive control 4.0142279E7 -6.11E7 -3.49 3.7700604E7 -5.11E7 -3.15 -4.6946 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D02 positive control 3.5939239E7 -6.53E7 -3.73 3.5698716E7 -5.31E7 -3.27 -4.9517 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D03 positive control 3.7891833E7 -6.33E7 -3.62 3.5237726E7 -5.35E7 -3.3 -4.8929 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D04 positive control 3.6820165E7 -6.44E7 -3.68 3.5221269E7 -5.36E7 -3.3 -4.937 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D05 positive control 3.5049202E7 -6.62E7 -3.78 3.5294153E7 -5.35E7 -3.3 -5.0054 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D06 positive control 3.580716E7 -6.54E7 -3.74 3.5260123E7 -5.35E7 -3.3 -4.9762 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D07 positive control 3.6725452E7 -6.45E7 -3.69 3.5697799E7 -5.31E7 -3.27 -4.92 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D08 positive control 3.5067969E7 -6.61E7 -3.78 3.4855141E7 -5.39E7 -3.32 -5.0237 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D09 positive control 3.4997513E7 -6.62E7 -3.78 3.4214929E7 -5.46E7 -3.36 -5.0545 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D10 positive control 3.4019377E7 -6.72E7 -3.84 3.439008E7 -5.44E7 -3.35 -5.0864 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D11 positive control 3.4892224E7 -6.63E7 -3.79 3.5389807E7 -5.34E7 -3.29 -5.0075 -0.9975 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D12 positive control 3.4417268E7 -6.68E7 -3.82 3.526654E7 -5.35E7 -3.3 -5.0321 -0.9974 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D13 mock treatment 8.1941653E7 -1.93E7 -1.1 8.3647381E7 -5130000.0 -0.32 -1.0027 -0.8749 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D14 mock treatment 8.8092203E7 -1.31E7 -0.75 8.7540752E7 -1240000.0 -0.08 -0.5844 -0.7752 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D15 mock treatment 9.0144238E7 -1.11E7 -0.63 8.545062E7 -3330000.0 -0.21 -0.5926 -0.8908 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D16 mock treatment 9.0371204E7 -1.08E7 -0.62 8.9333936E7 553000.0 0.03 -0.4142 -0.6672 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D17 mock treatment 9.3030389E7 -8190000.0 -0.47 8.6290082E7 -2490000.0 -0.15 -0.4394 -0.8924 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D18 mock treatment 9.7804239E7 -3410000.0 -0.2 8.2160593E7 -6620000.0 -0.41 -0.4265 -0.9429 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D19 mock treatment 1.00096554E8 -1120000.0 -0.06 8.9457363E7 676000.0 0.04 -0.0158 -0.2066 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D20 mock treatment 1.02407065E8 1190000.0 0.07 8.9711404E7 930000.0 0.06 0.0887 0.9964 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D21 mock treatment 1.04694302E8 3480000.0 0.2 8.8304911E7 -476000.0 -0.03 0.1198 0.5962 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D22 mock treatment 1.07390784E8 6170000.0 0.35 9.3983102E7 5200000.0 0.32 0.4763 0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D23 mock treatment 1.11712634E8 1.05E7 0.6 9.5565764E7 6780000.0 0.42 0.7199 0.9845 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon D24 mock treatment 1.187114E8 1.75E7 1.0 1.04869464E8 1.61E7 0.99 1.4083 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E01 positive control 4.1416149E7 -5.98E7 -3.42 3.8539034E7 -5.02E7 -3.1 -4.6066 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E02 positive control 3.6604471E7 -6.46E7 -3.69 3.7008768E7 -5.18E7 -3.19 -4.8678 -0.9974 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E03 positive control 3.9262387E7 -6.2E7 -3.54 3.7625105E7 -5.12E7 -3.15 -4.7335 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E04 positive control 3.7501112E7 -6.37E7 -3.64 3.4915092E7 -5.39E7 -3.32 -4.9228 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E05 positive control 3.762758E7 -6.36E7 -3.63 3.5493978E7 -5.33E7 -3.28 -4.8924 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E06 positive control 3.6278519E7 -6.49E7 -3.71 3.4285671E7 -5.45E7 -3.36 -4.9996 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E07 positive control 3.6705522E7 -6.45E7 -3.69 3.5011378E7 -5.38E7 -3.31 -4.9507 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E08 positive control 3.6489978E7 -6.47E7 -3.7 3.5105831E7 -5.37E7 -3.31 -4.9553 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E09 positive control 3.5363133E7 -6.59E7 -3.76 3.4450983E7 -5.43E7 -3.35 -5.0294 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E10 positive control 3.4428876E7 -6.68E7 -3.82 3.4206267E7 -5.46E7 -3.36 -5.0778 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E11 positive control 3.4574826E7 -6.66E7 -3.81 3.4830268E7 -5.4E7 -3.33 -5.0447 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E12 positive control 3.5495365E7 -6.57E7 -3.76 3.5543619E7 -5.32E7 -3.28 -4.9764 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E13 mock treatment 8.7245274E7 -1.4E7 -0.8 8.3258913E7 -5520000.0 -0.34 -0.8053 -0.9278 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E14 mock treatment 8.8797218E7 -1.24E7 -0.71 8.3614805E7 -5170000.0 -0.32 -0.7271 -0.9346 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E15 mock treatment 9.2805632E7 -8410000.0 -0.48 8.4787151E7 -3990000.0 -0.25 -0.514 -0.9517 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E16 mock treatment 9.4717438E7 -6500000.0 -0.37 8.3476589E7 -5300000.0 -0.33 -0.4939 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E17 mock treatment 9.8039427E7 -3180000.0 -0.18 8.2188194E7 -6590000.0 -0.41 -0.4158 -0.934 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E18 mock treatment 9.8912373E7 -2300000.0 -0.13 8.409046E7 -4690000.0 -0.29 -0.2976 -0.9366 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E19 mock treatment 9.9365623E7 -1850000.0 -0.11 8.7013234E7 -1770000.0 -0.11 -0.1519 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E20 mock treatment 1.02337867E8 1120000.0 0.06 8.4913469E7 -3870000.0 -0.24 -0.1233 -0.4993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E21 mock treatment 1.0487947E8 3660000.0 0.21 8.577521E7 -3010000.0 -0.19 0.017 0.0608 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E22 mock treatment 1.07003188E8 5790000.0 0.33 8.3043545E7 -5740000.0 -0.35 -0.0162 -0.0335 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E23 mock treatment 1.1174809E8 1.05E7 0.6 9.1902733E7 3120000.0 0.19 0.5617 0.8888 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon E24 mock treatment 1.1770221E8 1.65E7 0.94 1.01489411E8 1.27E7 0.78 1.2202 0.9958 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F01 positive control 3.8208608E7 -6.3E7 -3.6 3.5925322E7 -5.29E7 -3.26 -4.8502 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F02 positive control 3.6925105E7 -6.43E7 -3.67 3.5447544E7 -5.33E7 -3.29 -4.9229 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F03 positive control 3.7247952E7 -6.4E7 -3.66 3.5250472E7 -5.35E7 -3.3 -4.9184 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F04 positive control 3.4230342E7 -6.7E7 -3.83 3.4402517E7 -5.44E7 -3.35 -5.0773 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F05 positive control 3.5210005E7 -6.6E7 -3.77 3.4489392E7 -5.43E7 -3.35 -5.0339 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F06 positive control 3.4424711E7 -6.68E7 -3.82 3.3756806E7 -5.5E7 -3.39 -5.0976 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F07 positive control 3.6272693E7 -6.49E7 -3.71 3.4172475E7 -5.46E7 -3.37 -5.0048 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F08 positive control 3.5661296E7 -6.56E7 -3.75 3.3489429E7 -5.53E7 -3.41 -5.0593 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F09 positive control 3.4177241E7 -6.7E7 -3.83 3.2995299E7 -5.58E7 -3.44 -5.1408 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F10 positive control 3.5044475E7 -6.62E7 -3.78 3.3638895E7 -5.51E7 -3.4 -5.0777 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F11 positive control 3.4569931E7 -6.66E7 -3.81 3.4584397E7 -5.42E7 -3.34 -5.0557 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F12 positive control 3.3929394E7 -6.73E7 -3.85 3.3942287E7 -5.48E7 -3.38 -5.1095 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F13 mock treatment 8.4359289E7 -1.69E7 -0.96 8.0120265E7 -8660000.0 -0.53 -1.0587 -0.9612 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F14 mock treatment 8.5446145E7 -1.58E7 -0.9 7.8857149E7 -9920000.0 -0.61 -1.0699 -0.9822 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F15 mock treatment 9.16655E7 -9550000.0 -0.55 7.980108E7 -8980000.0 -0.55 -0.7774 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F16 mock treatment 8.9891787E7 -1.13E7 -0.65 7.8844542E7 -9940000.0 -0.61 -0.8908 -0.9996 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F17 mock treatment 9.4387598E7 -6830000.0 -0.39 8.0651557E7 -8130000.0 -0.5 -0.6303 -0.9924 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F18 mock treatment 9.908164E7 -2130000.0 -0.12 8.06464E7 -8130000.0 -0.5 -0.4408 -0.8542 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F19 mock treatment 1.01730414E8 514000.0 0.03 8.2849734E7 -5930000.0 -0.37 -0.2378 -0.6482 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F20 mock treatment 1.02024694E8 808000.0 0.05 8.7852932E7 -928000.0 -0.06 -0.0078 -0.106 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F21 mock treatment 1.09568512E8 8350000.0 0.48 8.4797646E7 -3980000.0 -0.25 0.1639 0.3053 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F22 mock treatment 1.06677292E8 5460000.0 0.31 8.2108161E7 -6670000.0 -0.41 -0.0702 -0.1359 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F23 mock treatment 1.08711629E8 7500000.0 0.43 8.6523861E7 -2260000.0 -0.14 0.2045 0.4541 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon F24 mock treatment 1.17920521E8 1.67E7 0.95 9.9628796E7 1.08E7 0.67 1.1479 0.9848 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G01 positive control 3.9281936E7 -6.19E7 -3.54 3.6600224E7 -5.22E7 -3.22 -4.7774 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G02 positive control 3.6976137E7 -6.42E7 -3.67 3.6502375E7 -5.23E7 -3.22 -4.8748 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G03 positive control 3.8649876E7 -6.26E7 -3.58 3.593448E7 -5.28E7 -3.26 -4.8319 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G04 positive control 3.8596946E7 -6.26E7 -3.58 3.7197131E7 -5.16E7 -3.18 -4.779 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G05 positive control 3.6697301E7 -6.45E7 -3.69 3.4100885E7 -5.47E7 -3.37 -4.9908 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G06 positive control 3.6875013E7 -6.43E7 -3.68 3.4677982E7 -5.41E7 -3.34 -4.9584 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G07 positive control 3.5639774E7 -6.56E7 -3.75 3.510759E7 -5.37E7 -3.31 -4.9896 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G08 positive control 3.6284962E7 -6.49E7 -3.71 3.5202685E7 -5.36E7 -3.3 -4.9594 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G09 positive control 3.6136598E7 -6.51E7 -3.72 3.3983326E7 -5.48E7 -3.38 -5.0185 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G10 positive control 3.4838663E7 -6.64E7 -3.79 3.4447063E7 -5.43E7 -3.35 -5.0508 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G11 positive control 3.5076246E7 -6.61E7 -3.78 3.4612802E7 -5.42E7 -3.34 -5.034 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G12 positive control 3.3744924E7 -6.75E7 -3.86 3.4797579E7 -5.4E7 -3.33 -5.0797 -0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G13 mock treatment 8.7107589E7 -1.41E7 -0.81 8.7200323E7 -1580000.0 -0.1 -0.6391 -0.7868 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G14 mock treatment 9.140166E7 -9810000.0 -0.56 8.5425009E7 -3360000.0 -0.21 -0.5429 -0.9081 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G15 mock treatment 9.35338E7 -7680000.0 -0.44 8.7526819E7 -1250000.0 -0.08 -0.3651 -0.819 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G16 mock treatment 9.462922E7 -6590000.0 -0.38 8.1012692E7 -7770000.0 -0.48 -0.6048 -0.9929 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G17 mock treatment 9.6757306E7 -4460000.0 -0.25 8.2709915E7 -6070000.0 -0.37 -0.4448 -0.9825 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G18 mock treatment 1.00667259E8 -549000.0 -0.03 8.7267867E7 -1510000.0 -0.09 -0.0882 -0.8956 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G19 mock treatment 1.00990418E8 -226000.0 -0.01 8.3610311E7 -5170000.0 -0.32 -0.2345 -0.7351 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G20 mock treatment 1.0434456E8 3130000.0 0.18 8.4258793E7 -4520000.0 -0.28 -0.0707 -0.2135 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G21 mock treatment 1.08941861E8 7730000.0 0.44 8.5142675E7 -3640000.0 -0.22 0.1536 0.3102 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G22 mock treatment 1.10245422E8 9030000.0 0.52 9.2926492E7 4150000.0 0.26 0.5456 0.9475 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G23 mock treatment 1.11059117E8 9840000.0 0.56 8.8673689E7 -108000.0 -0.01 0.3931 0.6987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon G24 mock treatment 1.1770161E8 1.65E7 0.94 1.00490528E8 1.17E7 0.72 1.1766 0.9913 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H01 positive control 3.8604768E7 -6.26E7 -3.58 3.5921042E7 -5.29E7 -3.26 -4.8343 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H02 positive control 3.8188566E7 -6.3E7 -3.6 3.4557592E7 -5.42E7 -3.34 -4.9106 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H03 positive control 3.6696033E7 -6.45E7 -3.69 3.4106523E7 -5.47E7 -3.37 -4.9906 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H04 positive control 3.6735398E7 -6.45E7 -3.69 3.4570761E7 -5.42E7 -3.34 -4.9687 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H05 positive control 3.5749723E7 -6.55E7 -3.74 3.3365578E7 -5.54E7 -3.42 -5.0611 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H06 positive control 3.6544285E7 -6.47E7 -3.7 3.4270244E7 -5.45E7 -3.36 -4.9896 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H07 positive control 3.5600689E7 -6.56E7 -3.75 3.3362318E7 -5.54E7 -3.42 -5.0673 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H08 positive control 3.5042616E7 -6.62E7 -3.78 3.4154793E7 -5.46E7 -3.37 -5.0553 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H09 positive control 3.4741959E7 -6.65E7 -3.8 3.2657212E7 -5.61E7 -3.46 -5.1327 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H10 positive control 3.4591043E7 -6.66E7 -3.81 3.3053923E7 -5.57E7 -3.44 -5.1215 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H11 positive control 3.3904588E7 -6.73E7 -3.85 3.2963256E7 -5.58E7 -3.44 -5.1532 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H12 positive control 3.3899574E7 -6.73E7 -3.85 3.3532608E7 -5.52E7 -3.41 -5.1286 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H13 mock treatment 8.5054371E7 -1.62E7 -0.92 8.1515617E7 -7270000.0 -0.45 -0.9698 -0.9448 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H14 mock treatment 8.9657656E7 -1.16E7 -0.66 8.1819351E7 -6960000.0 -0.43 -0.7706 -0.9782 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H15 mock treatment 9.158251E7 -9630000.0 -0.55 8.2008194E7 -6770000.0 -0.42 -0.6845 -0.9907 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H16 mock treatment 9.4751281E7 -6470000.0 -0.37 7.9046917E7 -9730000.0 -0.6 -0.6856 -0.9729 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H17 mock treatment 9.6264021E7 -4950000.0 -0.28 8.3356436E7 -5420000.0 -0.33 -0.4366 -0.9966 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H18 mock treatment 9.7817904E7 -3400000.0 -0.19 8.4798765E7 -3980000.0 -0.25 -0.3109 -0.9933 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H19 mock treatment 1.02175984E8 960000.0 0.05 8.3672744E7 -5110000.0 -0.31 -0.1839 -0.5753 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H20 mock treatment 1.02050487E8 834000.0 0.05 8.4247017E7 -4530000.0 -0.28 -0.1639 -0.5781 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H21 mock treatment 1.04853059E8 3640000.0 0.21 8.4091955E7 -4690000.0 -0.29 -0.0574 -0.1613 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H22 mock treatment 1.07659783E8 6440000.0 0.37 8.2961386E7 -5820000.0 -0.36 0.0067 0.0131 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H23 mock treatment 1.13765344E8 1.25E7 0.72 8.5628423E7 -3150000.0 -0.19 0.3697 0.4976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon H24 mock treatment 1.20866869E8 1.97E7 1.12 1.02539609E8 1.38E7 0.85 1.3938 0.9904 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I01 positive control 4.1067922E7 -6.01E7 -3.44 3.8168867E7 -5.06E7 -3.12 -4.6368 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I02 positive control 3.6830846E7 -6.44E7 -3.68 3.5146631E7 -5.36E7 -3.31 -4.9398 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I03 positive control 3.7348676E7 -6.39E7 -3.65 3.5286782E7 -5.35E7 -3.3 -4.9127 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I04 positive control 3.7767329E7 -6.34E7 -3.63 3.5657454E7 -5.31E7 -3.27 -4.8797 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I05 positive control 3.7018757E7 -6.42E7 -3.67 3.5199784E7 -5.36E7 -3.3 -4.9299 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I06 positive control 3.6083094E7 -6.51E7 -3.72 3.4125392E7 -5.47E7 -3.37 -5.0145 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I07 positive control 3.6139711E7 -6.51E7 -3.72 3.4982097E7 -5.38E7 -3.32 -4.9749 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I08 positive control 3.6813472E7 -6.44E7 -3.68 3.4127255E7 -5.47E7 -3.37 -4.9849 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I09 positive control 3.3291826E7 -6.79E7 -3.88 3.5606577E7 -5.32E7 -3.28 -5.0628 -0.9965 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I10 positive control 3.5481709E7 -6.57E7 -3.76 3.4651358E7 -5.41E7 -3.34 -5.0159 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I11 positive control 3.5165221E7 -6.61E7 -3.77 3.4475635E7 -5.43E7 -3.35 -5.0363 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I12 positive control 3.492398E7 -6.63E7 -3.79 3.4140638E7 -5.46E7 -3.37 -5.0607 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I13 mock treatment 8.7996702E7 -1.32E7 -0.76 8.4437639E7 -4340000.0 -0.27 -0.7236 -0.9027 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I14 mock treatment 9.131467E7 -9900000.0 -0.57 8.3745623E7 -5040000.0 -0.31 -0.6196 -0.96 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I15 mock treatment 9.5244302E7 -5970000.0 -0.34 9.2362522E7 3580000.0 0.22 -0.0852 -0.2097 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I16 mock treatment 9.7233186E7 -3980000.0 -0.23 8.5782371E7 -3000000.0 -0.18 -0.2917 -0.9947 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I17 mock treatment 9.652694E7 -4690000.0 -0.27 8.3188056E7 -5590000.0 -0.34 -0.4333 -0.9922 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I18 mock treatment 9.7768453E7 -3450000.0 -0.2 8.8273521E7 -508000.0 -0.03 -0.1615 -0.8093 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I19 mock treatment 9.723085E7 -3990000.0 -0.23 8.7768356E7 -1010000.0 -0.06 -0.2052 -0.8689 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I20 mock treatment 1.01927272E8 711000.0 0.04 8.5215369E7 -3570000.0 -0.22 -0.1267 -0.5668 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I21 mock treatment 1.03822845E8 2610000.0 0.15 8.5933484E7 -2850000.0 -0.18 -0.0188 -0.0816 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I22 mock treatment 1.06382729E8 5170000.0 0.3 8.8651995E7 -129000.0 -0.01 0.2032 0.6878 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I23 mock treatment 1.11382088E8 1.02E7 0.58 9.3199416E7 4420000.0 0.27 0.6034 0.9404 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon I24 mock treatment 1.19418905E8 1.82E7 1.04 1.05144627E8 1.64E7 1.01 1.4489 0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J01 positive control 3.9939768E7 -6.13E7 -3.5 3.7848909E7 -5.09E7 -3.14 -4.6964 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J02 positive control 3.8276944E7 -6.29E7 -3.6 3.4765698E7 -5.4E7 -3.33 -4.8979 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J03 positive control 3.7896021E7 -6.33E7 -3.62 3.5296786E7 -5.35E7 -3.3 -4.8902 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J04 positive control 3.4865835E7 -6.64E7 -3.79 3.4020605E7 -5.48E7 -3.38 -5.0683 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J05 positive control 3.5235572E7 -6.6E7 -3.77 3.4071306E7 -5.47E7 -3.37 -5.0511 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J06 positive control 3.4868202E7 -6.63E7 -3.79 3.3423899E7 -5.54E7 -3.41 -5.0942 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J07 positive control 3.4633413E7 -6.66E7 -3.81 3.3044947E7 -5.57E7 -3.44 -5.1202 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J08 positive control 3.5905405E7 -6.53E7 -3.73 3.4181944E7 -5.46E7 -3.37 -5.0192 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J09 positive control 3.5654663E7 -6.56E7 -3.75 3.3940698E7 -5.48E7 -3.38 -5.0399 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J10 positive control 3.4427411E7 -6.68E7 -3.82 3.2983276E7 -5.58E7 -3.44 -5.1312 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J11 positive control 3.4401415E7 -6.68E7 -3.82 3.3421162E7 -5.54E7 -3.41 -5.1132 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J12 positive control 3.4302236E7 -6.69E7 -3.82 3.3530071E7 -5.53E7 -3.41 -5.1124 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J13 mock treatment 8.8355373E7 -1.29E7 -0.74 8.2014116E7 -6770000.0 -0.42 -0.8147 -0.964 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J14 mock treatment 9.0313259E7 -1.09E7 -0.62 8.178461E7 -7000000.0 -0.43 -0.7456 -0.9838 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J15 mock treatment 9.4384614E7 -6830000.0 -0.39 8.2916431E7 -5860000.0 -0.36 -0.5317 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J16 mock treatment 9.5912516E7 -5300000.0 -0.3 8.3793553E7 -4990000.0 -0.31 -0.4317 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J17 mock treatment 9.6150071E7 -5070000.0 -0.29 8.6110991E7 -2670000.0 -0.16 -0.3211 -0.9642 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J18 mock treatment 9.8923966E7 -2290000.0 -0.13 8.4481649E7 -4300000.0 -0.27 -0.28 -0.9472 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J19 mock treatment 9.9002229E7 -2210000.0 -0.13 8.3229988E7 -5550000.0 -0.34 -0.3314 -0.9085 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J20 mock treatment 1.04029208E8 2810000.0 0.16 8.9522178E7 741000.0 0.05 0.146 0.8734 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J21 mock treatment 1.04912172E8 3700000.0 0.21 8.4177391E7 -4600000.0 -0.28 -0.0513 -0.145 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J22 mock treatment 1.0566329E8 4450000.0 0.25 9.0514455E7 1730000.0 0.11 0.2553 0.9259 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J23 mock treatment 1.10097817E8 8880000.0 0.51 9.93934E7 1.06E7 0.65 0.8215 0.9921 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon J24 mock treatment 1.18804624E8 1.76E7 1.01 1.070435E8 1.83E7 1.13 1.5068 0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K01 positive control 4.2127273E7 -5.91E7 -3.38 3.8195774E7 -5.06E7 -3.12 -4.5928 -0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K02 positive control 3.4651183E7 -6.66E7 -3.8 3.5119381E7 -5.37E7 -3.31 -5.0291 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K03 positive control 3.564712E7 -6.56E7 -3.75 3.5733767E7 -5.3E7 -3.27 -4.962 -0.9977 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K04 positive control 3.8172178E7 -6.3E7 -3.6 3.6090195E7 -5.27E7 -3.25 -4.8444 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K05 positive control 3.4323099E7 -6.69E7 -3.82 3.4136932E7 -5.46E7 -3.37 -5.0851 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K06 positive control 3.5416079E7 -6.58E7 -3.76 3.3154438E7 -5.56E7 -3.43 -5.0838 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K07 positive control 3.6826711E7 -6.44E7 -3.68 3.5222869E7 -5.36E7 -3.3 -4.9366 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K08 positive control 3.6092906E7 -6.51E7 -3.72 3.3394293E7 -5.54E7 -3.41 -5.046 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K09 positive control 3.5116028E7 -6.61E7 -3.78 3.3915132E7 -5.49E7 -3.38 -5.0628 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K10 positive control 3.5448824E7 -6.58E7 -3.76 3.4183433E7 -5.46E7 -3.37 -5.0376 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K11 positive control 3.5577737E7 -6.56E7 -3.75 3.4463813E7 -5.43E7 -3.35 -5.0202 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K12 positive control 3.5087619E7 -6.61E7 -3.78 3.3517631E7 -5.53E7 -3.41 -5.0812 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K13 mock treatment 8.9762405E7 -1.15E7 -0.65 8.4626566E7 -4150000.0 -0.26 -0.644 -0.9161 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K14 mock treatment 9.4203088E7 -7010000.0 -0.4 8.3461642E7 -5320000.0 -0.33 -0.5153 -0.995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K15 mock treatment 9.5940296E7 -5280000.0 -0.3 8.4824028E7 -3960000.0 -0.24 -0.3857 -0.9945 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K16 mock treatment 9.8630085E7 -2590000.0 -0.15 8.4583339E7 -4200000.0 -0.26 -0.2875 -0.9647 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K17 mock treatment 9.9885492E7 -1330000.0 -0.08 8.5345352E7 -3440000.0 -0.21 -0.2035 -0.9045 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K18 mock treatment 9.8187797E7 -3030000.0 -0.17 8.7855812E7 -925000.0 -0.06 -0.1627 -0.8929 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K19 mock treatment 1.02509359E8 1290000.0 0.07 8.6268396E7 -2510000.0 -0.15 -0.0573 -0.3337 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K20 mock treatment 1.05592278E8 4380000.0 0.25 8.5495614E7 -3290000.0 -0.2 0.0336 0.1045 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K21 mock treatment 1.07938867E8 6720000.0 0.38 9.0498077E7 1720000.0 0.11 0.3465 0.8695 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K22 mock treatment 1.10739432E8 9520000.0 0.54 9.2322486E7 3540000.0 0.22 0.5392 0.9195 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K23 mock treatment 1.10794801E8 9580000.0 0.55 9.5902927E7 7120000.0 0.44 0.6975 0.994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon K24 mock treatment 1.20081466E8 1.89E7 1.08 1.05589443E8 1.68E7 1.04 1.495 0.9998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L01 positive control 4.0496318E7 -6.07E7 -3.47 3.6260841E7 -5.25E7 -3.24 -4.7431 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L02 positive control 3.7465365E7 -6.38E7 -3.64 3.4938667E7 -5.38E7 -3.32 -4.9232 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L03 positive control 3.635716E7 -6.49E7 -3.71 3.5117855E7 -5.37E7 -3.31 -4.9602 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L04 positive control 3.5427083E7 -6.58E7 -3.76 3.6108066E7 -5.27E7 -3.25 -4.9546 -0.9973 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L05 positive control 3.6622962E7 -6.46E7 -3.69 3.3836021E7 -5.49E7 -3.39 -5.0053 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L06 positive control 3.5427666E7 -6.58E7 -3.76 3.3907236E7 -5.49E7 -3.38 -5.0505 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L07 positive control 3.5007913E7 -6.62E7 -3.78 3.3918408E7 -5.49E7 -3.38 -5.067 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L08 positive control 3.5412761E7 -6.58E7 -3.76 3.3496584E7 -5.53E7 -3.41 -5.069 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L09 positive control 3.5467197E7 -6.57E7 -3.76 3.3622271E7 -5.52E7 -3.4 -5.0613 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L10 positive control 3.5863134E7 -6.54E7 -3.74 3.4253824E7 -5.45E7 -3.36 -5.0178 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L11 positive control 3.3817411E7 -6.74E7 -3.85 3.3318927E7 -5.55E7 -3.42 -5.1412 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L12 positive control 3.4915073E7 -6.63E7 -3.79 3.3959019E7 -5.48E7 -3.38 -5.069 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L13 mock treatment 9.1044518E7 -1.02E7 -0.58 7.9440918E7 -9340000.0 -0.58 -0.8182 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L14 mock treatment 9.2550189E7 -8670000.0 -0.5 7.9982494E7 -8800000.0 -0.54 -0.7337 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L15 mock treatment 9.5131391E7 -6080000.0 -0.35 8.4004826E7 -4780000.0 -0.29 -0.4541 -0.9966 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L16 mock treatment 9.5615376E7 -5600000.0 -0.32 8.3734818E7 -5050000.0 -0.31 -0.4463 -0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L17 mock treatment 9.9635541E7 -1580000.0 -0.09 8.4608907E7 -4170000.0 -0.26 -0.2457 -0.9015 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L18 mock treatment 9.7736254E7 -3480000.0 -0.2 8.5183031E7 -3600000.0 -0.22 -0.2975 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L19 mock treatment 1.03991925E8 2780000.0 0.16 8.442433E7 -4360000.0 -0.27 -0.0777 -0.2492 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L20 mock treatment 1.05327451E8 4110000.0 0.23 9.5481797E7 6700000.0 0.41 0.4582 0.9642 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L21 mock treatment 1.0724933E8 6030000.0 0.34 8.9984374E7 1200000.0 0.07 0.2963 0.84 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L22 mock treatment 1.07880262E8 6660000.0 0.38 8.952981E7 749000.0 0.05 0.3019 0.787 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L23 mock treatment 1.11260979E8 1.0E7 0.57 9.6220618E7 7440000.0 0.46 0.7302 0.9938 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon L24 mock treatment 1.23754879E8 2.25E7 1.29 1.07503671E8 1.87E7 1.15 1.7269 0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M01 positive control 4.1580346E7 -5.96E7 -3.41 3.8516722E7 -5.03E7 -3.1 -4.6009 -0.9989 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M02 positive control 3.8626524E7 -6.26E7 -3.58 3.4897636E7 -5.39E7 -3.32 -4.8781 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M03 positive control 3.6680185E7 -6.45E7 -3.69 3.5144581E7 -5.36E7 -3.31 -4.946 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M04 positive control 3.8558521E7 -6.27E7 -3.58 3.5050395E7 -5.37E7 -3.31 -4.8742 -0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M05 positive control 3.5033244E7 -6.62E7 -3.78 3.506866E7 -5.37E7 -3.31 -5.0158 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M06 positive control 3.5644947E7 -6.56E7 -3.75 3.3684452E7 -5.51E7 -3.4 -5.0514 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M07 positive control 3.6957454E7 -6.43E7 -3.67 3.4177517E7 -5.46E7 -3.37 -4.9769 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M08 positive control 3.5428058E7 -6.58E7 -3.76 3.4003337E7 -5.48E7 -3.38 -5.0463 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M09 positive control 3.7050629E7 -6.42E7 -3.67 3.3769482E7 -5.5E7 -3.39 -4.9909 -0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M10 positive control 3.6171888E7 -6.5E7 -3.72 3.3570781E7 -5.52E7 -3.4 -5.0351 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M11 positive control 3.4473629E7 -6.67E7 -3.81 3.3222337E7 -5.56E7 -3.42 -5.1189 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M12 positive control 3.667569E7 -6.45E7 -3.69 3.3834612E7 -5.49E7 -3.39 -5.0032 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M13 mock treatment 9.2906504E7 -8310000.0 -0.47 8.0944395E7 -7840000.0 -0.48 -0.6774 -1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M14 mock treatment 9.647601E7 -4740000.0 -0.27 8.1796811E7 -6980000.0 -0.43 -0.496 -0.9751 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M15 mock treatment 9.7367816E7 -3850000.0 -0.22 8.4951367E7 -3830000.0 -0.24 -0.3225 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M16 mock treatment 9.9998596E7 -1220000.0 -0.07 8.3113728E7 -5670000.0 -0.35 -0.2962 -0.8316 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M17 mock treatment 9.851742E7 -2700000.0 -0.15 8.2919793E7 -5860000.0 -0.36 -0.3646 -0.928 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M18 mock treatment 1.01311443E8 95100.0 0.01 8.3365274E7 -5420000.0 -0.33 -0.2322 -0.6955 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M19 mock treatment 1.04765843E8 3550000.0 0.2 8.4706275E7 -4070000.0 -0.25 -0.0342 -0.1058 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M20 mock treatment 1.06197335E8 4980000.0 0.28 8.8334819E7 -446000.0 -0.03 0.1818 0.6358 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M21 mock treatment 1.07343762E8 6130000.0 0.35 8.8175819E7 -605000.0 -0.04 0.2212 0.6282 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M22 mock treatment 1.09803503E8 8590000.0 0.49 9.2992115E7 4210000.0 0.26 0.5306 0.9557 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M23 mock treatment 1.13912695E8 1.27E7 0.73 9.3129175E7 4350000.0 0.27 0.7026 0.9083 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon M24 mock treatment 1.23304991E8 2.21E7 1.26 1.11963835E8 2.32E7 1.43 1.9031 0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N01 positive control 4.1700378E7 -5.95E7 -3.4 3.7258838E7 -5.15E7 -3.18 -4.6509 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N02 positive control 3.6506511E7 -6.47E7 -3.7 3.5393164E7 -5.34E7 -3.29 -4.9421 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N03 positive control 3.5318544E7 -6.59E7 -3.77 3.419993E7 -5.46E7 -3.36 -5.0422 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N04 positive control 3.6121172E7 -6.51E7 -3.72 3.3311696E7 -5.55E7 -3.42 -5.0484 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N05 positive control 3.6042485E7 -6.52E7 -3.72 3.3135471E7 -5.56E7 -3.43 -5.0593 -0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N06 positive control 3.5294156E7 -6.59E7 -3.77 3.328282E7 -5.55E7 -3.42 -5.0831 -0.9988 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N07 positive control 3.5149293E7 -6.61E7 -3.78 3.3406739E7 -5.54E7 -3.41 -5.0836 -0.9987 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N08 positive control 3.6383475E7 -6.48E7 -3.71 3.359412E7 -5.52E7 -3.4 -5.0255 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N09 positive control 3.5651403E7 -6.56E7 -3.75 3.2711731E7 -5.61E7 -3.46 -5.0936 -0.9992 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N10 positive control 3.5394761E7 -6.58E7 -3.76 3.2608617E7 -5.62E7 -3.46 -5.1084 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N11 positive control 3.3886773E7 -6.73E7 -3.85 3.2577094E7 -5.62E7 -3.46 -5.1708 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N12 positive control 3.5040041E7 -6.62E7 -3.78 3.3507678E7 -5.53E7 -3.41 -5.0836 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N13 mock treatment 9.3218265E7 -8000000.0 -0.46 7.8003577E7 -1.08E7 -0.66 -0.793 -0.9833 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N14 mock treatment 9.451056E7 -6710000.0 -0.38 7.7888135E7 -1.09E7 -0.67 -0.7458 -0.9646 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N15 mock treatment 9.9072427E7 -2140000.0 -0.12 7.9865113E7 -8920000.0 -0.55 -0.4753 -0.844 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N16 mock treatment 9.8837731E7 -2380000.0 -0.14 7.9340915E7 -9440000.0 -0.58 -0.5076 -0.8494 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N17 mock treatment 1.01169823E8 -46500.0 0.0 8.3856299E7 -4920000.0 -0.3 -0.2165 -0.7133 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N18 mock treatment 1.02809652E8 1590000.0 0.09 8.3977821E7 -4800000.0 -0.3 -0.145 -0.468 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N19 mock treatment 1.0233386E8 1120000.0 0.06 8.6369075E7 -2410000.0 -0.15 -0.06 -0.3706 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N20 mock treatment 1.07019149E8 5800000.0 0.33 9.5421648E7 6640000.0 0.41 0.5239 0.9945 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N21 mock treatment 1.08215098E8 7000000.0 0.4 8.873568E7 -45500.0 0.0 0.2809 0.7021 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N22 mock treatment 1.09410563E8 8190000.0 0.47 9.066032E7 1880000.0 0.12 0.4131 0.8562 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N23 mock treatment 1.13011E8 1.18E7 0.67 9.4201937E7 5420000.0 0.33 0.7129 0.9476 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon N24 mock treatment 1.19949624E8 1.87E7 1.07 1.05902064E8 1.71E7 1.06 1.5033 1.0 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O01 positive control 4.0931997E7 -6.03E7 -3.45 3.9664475E7 -4.91E7 -3.03 -4.5771 -0.9979 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O02 positive control 3.7054095E7 -6.42E7 -3.67 3.6112203E7 -5.27E7 -3.25 -4.8887 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O03 positive control 3.4065174E7 -6.72E7 -3.84 3.5830707E7 -5.3E7 -3.26 -5.0217 -0.9968 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O04 positive control 3.5099002E7 -6.61E7 -3.78 3.4682546E7 -5.41E7 -3.33 -5.03 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O05 positive control 3.5227441E7 -6.6E7 -3.77 3.4213944E7 -5.46E7 -3.36 -5.0452 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O06 positive control 3.6731639E7 -6.45E7 -3.69 3.2981196E7 -5.58E7 -3.44 -5.0382 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O07 positive control 3.6502634E7 -6.47E7 -3.7 3.356279E7 -5.52E7 -3.4 -5.0221 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O08 positive control 3.543636E7 -6.58E7 -3.76 3.2920709E7 -5.59E7 -3.44 -5.0932 -0.999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O09 positive control 3.6460879E7 -6.48E7 -3.7 3.3667329E7 -5.51E7 -3.4 -5.0192 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O10 positive control 3.6735473E7 -6.45E7 -3.69 3.3061638E7 -5.57E7 -3.43 -5.0345 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O11 positive control 3.6277092E7 -6.49E7 -3.71 3.2899306E7 -5.59E7 -3.44 -5.0601 -0.9993 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O12 positive control 3.6179766E7 -6.5E7 -3.72 3.3349467E7 -5.54E7 -3.42 -5.0444 -0.9991 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O13 mock treatment 9.8774889E7 -2440000.0 -0.14 7.9541154E7 -9240000.0 -0.57 -0.5014 -0.855 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O14 mock treatment 9.9202327E7 -2010000.0 -0.12 8.1234932E7 -7550000.0 -0.47 -0.4103 -0.8563 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O15 mock treatment 1.0058649E8 -630000.0 -0.04 7.8677438E7 -1.01E7 -0.62 -0.4659 -0.7467 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O16 mock treatment 1.00993728E8 -223000.0 -0.01 8.0168058E7 -8610000.0 -0.53 -0.3844 -0.7238 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O17 mock treatment 1.04269887E8 3050000.0 0.17 8.3359187E7 -5420000.0 -0.33 -0.1129 -0.2995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O18 mock treatment 1.06155006E8 4940000.0 0.28 8.5021916E7 -3760000.0 -0.23 0.0357 0.0978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O19 mock treatment 1.07872577E8 6660000.0 0.38 8.8747487E7 -33700.0 0.0 0.2675 0.7032 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O20 mock treatment 1.01462315E8 246000.0 0.01 8.4426033E7 -4360000.0 -0.27 -0.1799 -0.6692 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O21 mock treatment 1.10408006E8 9190000.0 0.53 9.1450081E7 2670000.0 0.16 0.4878 0.8861 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O22 mock treatment 1.09918788E8 8700000.0 0.5 9.3731828E7 4950000.0 0.31 0.5675 0.9725 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O23 mock treatment 1.12455599E8 1.12E7 0.64 9.5744625E7 6960000.0 0.43 0.7577 0.9808 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon O24 mock treatment 1.19985534E8 1.88E7 1.07 1.06630981E8 1.78E7 1.1 1.5365 0.9999 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P01 positive control 3.9671576E7 -6.15E7 -3.52 3.8828344E7 -5.0E7 -3.08 -4.6645 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P02 positive control 3.8607953E7 -6.26E7 -3.58 3.6833237E7 -5.19E7 -3.2 -4.7944 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P03 positive control 3.5086038E7 -6.61E7 -3.78 3.5414852E7 -5.34E7 -3.29 -4.9986 -0.9976 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P04 positive control 3.4817473E7 -6.64E7 -3.79 3.48092E7 -5.4E7 -3.33 -5.0359 -0.9978 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P05 positive control 3.5833014E7 -6.54E7 -3.74 3.4880196E7 -5.39E7 -3.32 -4.9917 -0.9983 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P06 positive control 3.5919469E7 -6.53E7 -3.73 3.5085126E7 -5.37E7 -3.31 -4.9793 -0.9982 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P07 positive control 3.7086255E7 -6.41E7 -3.67 3.6294553E7 -5.25E7 -3.24 -4.8794 -0.9981 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P08 positive control 3.3787244E7 -6.74E7 -3.85 3.3718016E7 -5.51E7 -3.39 -5.1251 -0.998 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P09 positive control 3.4907361E7 -6.63E7 -3.79 3.3908619E7 -5.49E7 -3.38 -5.0715 -0.9984 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P10 positive control 3.4412948E7 -6.68E7 -3.82 3.3296196E7 -5.55E7 -3.42 -5.1182 -0.9985 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P11 positive control 3.537053E7 -6.58E7 -3.76 3.3813684E7 -5.5E7 -3.39 -5.0569 -0.9986 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P12 positive control 3.7759763E7 -6.35E7 -3.63 3.4001669E7 -5.48E7 -3.38 -4.9521 -0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P13 mock treatment 1.05544552E8 4330000.0 0.25 8.2539594E7 -6240000.0 -0.38 -0.0971 -0.2124 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P14 mock treatment 9.6438196E7 -4780000.0 -0.27 8.2504371E7 -6280000.0 -0.39 -0.4667 -0.9854 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P15 mock treatment 9.822088E7 -3000000.0 -0.17 8.391804E7 -4860000.0 -0.3 -0.333 -0.9647 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P16 mock treatment 1.01565271E8 349000.0 0.02 8.927905E7 498000.0 0.03 0.0358 0.9782 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P17 mock treatment 1.07165851E8 5950000.0 0.34 9.2293868E7 3510000.0 0.22 0.3935 0.9763 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P18 mock treatment 1.00089288E8 -1130000.0 -0.06 8.8467951E7 -313000.0 -0.02 -0.0592 -0.8804 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P19 mock treatment 1.05115371E8 3900000.0 0.22 9.4375875E7 5590000.0 0.34 0.4014 0.9777 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P20 mock treatment 1.07339111E8 6120000.0 0.35 9.4064335E7 5280000.0 0.33 0.4777 0.9994 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P21 mock treatment 1.0974163E8 8530000.0 0.49 9.5242067E7 6460000.0 0.4 0.6261 0.995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P22 mock treatment 1.16298452E8 1.51E7 0.86 1.00761843E8 1.2E7 0.74 1.1317 0.997 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P23 mock treatment 1.22065485E8 2.08E7 1.19 1.06946266E8 1.82E7 1.12 1.6343 0.9995 1111.0001 CellTiterBlue(1111.0001) GSISyntheticLethal 1111.0001.PosCon P24 mock treatment 1.30901725E8 2.97E7 1.7 1.15037101E8 2.63E7 1.62 2.3441 0.9997