ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A01 compound treatment 179760.0 7020.0 0.27 157040.0 -15600.0 -0.58 -0.2206 -0.3421 1205993 ChemDiv3_000001 Cc1cc(c(O)c(c1)C(C)(C)C)n2nc3ccc(Cl)cc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A02 compound treatment 173400.0 660.0 0.03 172320.0 -289.0 -0.01 0.0104 0.3756 1044707 ChemDiv3_000002 OC(=O)c1ccccc1C(=O)c2ccc(cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A03 compound treatment 168120.0 -4620.0 -0.18 161880.0 -10700.0 -0.4 -0.4115 -0.9336 1699093 ChemDiv3_000003 Cc1ccc(Nc2ccc3ncnc4-c5ccccc5C(=O)c2c43)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A04 compound treatment 161480.0 -11300.0 -0.44 169040.0 -3570.0 -0.13 -0.4036 -0.8833 3117569 ChemDiv3_000004 Clc1c(sc2ccccc12)C(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A05 compound treatment 161840.0 -10900.0 -0.42 136960.0 -35600.0 -1.34 -1.2451 -0.8873 1561677 ChemDiv3_000005 CCOC(=O)c1c(O)nc2c3ccccc3oc2c1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A06 compound treatment 156680.0 -16100.0 -0.62 142600.0 -30000.0 -1.13 -1.237 -0.961 3117570 ChemDiv3_000006 CN(C)C(=O)C[n+]1ccc(/C=N/O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A07 compound treatment 160160.0 -12600.0 -0.49 159600.0 -13000.0 -0.49 -0.6904 -1.0 1166193 ChemDiv3_000007 CCCC1CCC(CC1)c2ccc(cc2)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A08 compound treatment 137400.0 -35300.0 -1.37 130600.0 -42000.0 -1.58 -2.0845 -0.9976 3019825 ChemDiv3_000008 C(c1ccccc1)[n+]2ccc(cc2)c3nc4ccccc4s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A09 compound treatment 9480.0 -163000.0 -6.33 7280.0 -165000.0 -6.21 -8.8668 -0.9999 1640201 ChemDiv3_000009 CCCc1ccc(OC(=O)c2ccc(O)cc2Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A10 compound treatment 15160.0 -158000.0 -6.11 13000.0 -160000.0 -5.99 -8.5592 -0.9999 1305993 ChemDiv3_000010 Cc1sc(N)nc1C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A11 compound treatment 153200.0 -19500.0 -0.76 135000.0 -37600.0 -1.41 -1.5342 -0.9575 3019826 ChemDiv3_000011 CCN1C(=O)/C(=C/C=C\2/Sc3ccccc3N2CC)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A12 compound treatment 145120.0 -27600.0 -1.07 144200.0 -28400.0 -1.07 -1.5117 -1.0 1005107 ChemDiv3_000012 CC(C)(C)C(=O)C[n+]1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A13 compound treatment 153960.0 -18800.0 -0.73 128040.0 -44600.0 -1.67 -1.6981 -0.9307 1917998 ChemDiv3_000013 CN(C)c1ccc(cc1)c2n(C)c3ccccc3[n+]2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A14 compound treatment 136800.0 -35900.0 -1.39 148080.0 -24500.0 -0.92 -1.637 -0.9797 3117571 ChemDiv3_000014 O/N=C/c1cc[n+](C/C=C\c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A15 compound treatment 149000.0 -23700.0 -0.92 142600.0 -30000.0 -1.13 -1.4477 -0.995 1511477 ChemDiv3_000015 Cc1ccc(cc1)S(=O)(=O)c2ccc(cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A16 compound treatment 142360.0 -30400.0 -1.18 137320.0 -35300.0 -1.32 -1.77 -0.9983 1463254 ChemDiv3_000016 C(CN1CCOCC1)Oc2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A17 compound treatment 81800.0 -90900.0 -3.53 97640.0 -75000.0 -2.81 -4.4846 -0.9937 1289110 ChemDiv3_000017 N#CC(=c1ccc(=C(C#N)c2ccc(cc2)N3CCCC3)cc1)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A18 compound treatment 162240.0 -10500.0 -0.41 167400.0 -5210.0 -0.2 -0.4263 -0.9434 1594677 ChemDiv3_000018 CC(C)CN(CC(C)C)Cn1c(=O)oc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A19 compound treatment 144800.0 -27900.0 -1.08 151600.0 -21000.0 -0.79 -1.3241 -0.9878 1914297 ChemDiv3_000019 COc1ccc(/C=N/n2cnnc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A20 compound treatment 95280.0 -77500.0 -3.01 62360.0 -110000.0 -4.14 -5.0511 -0.9877 1550111 ChemDiv3_000020 CC(C)C1CCC(C)C(C(O)c2ccc(cc2)c3ccccc3)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A21 compound treatment 158320.0 -14400.0 -0.56 133480.0 -39100.0 -1.47 -1.4341 -0.9125 3019827 ChemDiv3_000021 CN(C)c1ccc(/C=C/C=C/c2cc[n+](C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A22 compound treatment 158120.0 -14600.0 -0.57 173440.0 831.0 0.03 -0.3791 -0.6672 1470588 ChemDiv3_000022 Fc1ccccc1C(=O)Oc2cccc(OC(=O)c3ccccc3F)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A23 mock treatment 170520.0 -2220.0 -0.09 167880.0 -4730.0 -0.18 -0.1864 -0.9449 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 A24 mock treatment 166360.0 -6380.0 -0.25 164600.0 -8010.0 -0.3 -0.3876 -0.9954 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B01 compound treatment 191600.0 18900.0 0.73 162280.0 -10300.0 -0.39 0.2433 0.2938 3117572 ChemDiv3_000023 COc1ccc(/C=N/c2ccc(OCC(O)CN3C(C)CCCC3C)cc2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B02 compound treatment 175920.0 3180.0 0.12 173880.0 1270.0 0.05 0.121 0.9145 1476169 ChemDiv3_000024 CC(C)(C)NC(=O)C1(CC2CC3C1)CC(C2)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B03 compound treatment 169680.0 -3060.0 -0.12 170800.0 -1810.0 -0.07 -0.132 -0.9648 1164812 ChemDiv3_000025 O(c1ccccc1)c2cccc(Oc3ccccc3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B04 compound treatment 172800.0 60.0 0.0 151840.0 -20800.0 -0.78 -0.5495 -0.705 3019828 ChemDiv3_000026 Brc1ccc(/C=N/C2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B05 compound treatment 31280.0 -141000.0 -5.49 13560.0 -159000.0 -5.97 -8.1021 -0.9991 2083946 ChemDiv3_000027 O=C(/C=C/c1ccccc1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B06 compound treatment 165240.0 -7500.0 -0.29 159320.0 -13300.0 -0.5 -0.5584 -0.9671 3117574 ChemDiv3_000028 CC1(CC2(C)CC3(C)C1)CC(C/N=C/c4ccc(O)cc4)(C2)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B07 compound treatment 160360.0 -12400.0 -0.48 123480.0 -49100.0 -1.84 -1.6435 -0.8625 1666537 ChemDiv3_000029 COC(=O)NCC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B08 compound treatment 153280.0 -19500.0 -0.76 133360.0 -39200.0 -1.47 -1.5755 -0.9518 1021487 ChemDiv3_000030 C1CN(CCN1c2ccccn2)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B09 compound treatment 156160.0 -16600.0 -0.64 159400.0 -13200.0 -0.5 -0.8054 -0.9917 3019829 ChemDiv3_000031 COc1ccc(/C=N/c2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B10 compound treatment 147760.0 -25000.0 -0.97 145400.0 -27200.0 -1.02 -1.4074 -0.9997 1699181 ChemDiv3_000032 Cc1c(NC(=O)c2ccccc2)c(=O)n(c3ccccc3)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B11 compound treatment 134720.0 -38000.0 -1.48 146240.0 -26400.0 -0.99 -1.7429 -0.9811 3019830 ChemDiv3_000033 CC(C)Cc1ccc(cc1)C(C)C(=O)NC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B12 compound treatment 133280.0 -39500.0 -1.53 141840.0 -30800.0 -1.15 -1.8992 -0.9903 3117575 ChemDiv3_000034 COc1ccc(/C=C/2\CC/C(=C\c3ccc(C)cc3)/C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B13 compound treatment 137080.0 -35700.0 -1.38 151000.0 -21600.0 -0.81 -1.5518 -0.9676 1119180 ChemDiv3_000035 CNC(=O)c1ccc(Oc2ccc(cc2)C(=O)NC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B14 compound treatment 17920.0 -155000.0 -6.01 18640.0 -154000.0 -5.78 -8.3338 -0.9998 1616129 ChemDiv3_000036 CC(=O)Nc1cccc(Oc2ccc3C(=O)N(C(=O)c3c2)c4ccc(Oc5ccc(C)c(C)c5)cc4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B15 compound treatment 127400.0 -45300.0 -1.76 154240.0 -18400.0 -0.69 -1.7314 -0.9164 1336672 ChemDiv3_000037 O=C(Nc1cc(=O)c2ccccc2o1)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B16 compound treatment 155840.0 -16900.0 -0.66 144080.0 -28500.0 -1.07 -1.2208 -0.9723 3117576 ChemDiv3_000038 CC[n+]1ccc(C)c2cc(ccc12)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B17 compound treatment 135200.0 -37500.0 -1.46 96280.0 -76300.0 -2.86 -3.0556 -0.9508 3019831 ChemDiv3_000039 NNC(=S)NC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B18 compound treatment 169200.0 -3540.0 -0.14 152200.0 -20400.0 -0.77 -0.6388 -0.8208 1270265 ChemDiv3_000040 Clc1ccc(cc1)S(=O)(=O)n2cnc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B19 compound treatment 181520.0 8780.0 0.34 149880.0 -22700.0 -0.85 -0.3623 -0.3944 3117577 ChemDiv3_000041 Cc1cc(nc2ccc3ccccc3c12)c4ccc5ccccc5n4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B20 compound treatment 148280.0 -24500.0 -0.95 149680.0 -22900.0 -0.86 -1.2796 -0.9988 1591919 ChemDiv3_000042 CNc1ccc(cc1)S(=O)(=O)c2ccc(NC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B21 compound treatment 12200.0 -161000.0 -6.23 11120.0 -161000.0 -6.06 -8.6903 -0.9999 3117578 ChemDiv3_000043 O=C(C1=C(C(=O)c2ccccc2C1=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B22 compound treatment 164360.0 -8380.0 -0.33 164360.0 -8250.0 -0.31 -0.4488 -0.9997 1583295 ChemDiv3_000044 Brc1ccc(OC(=O)c2cccnc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B23 mock treatment 163800.0 -8940.0 -0.35 163680.0 -8930.0 -0.34 -0.4822 -0.9999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 B24 mock treatment 170360.0 -2380.0 -0.09 161240.0 -11400.0 -0.43 -0.367 -0.8407 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C01 compound treatment 173200.0 460.0 0.02 168840.0 -3770.0 -0.14 -0.0874 -0.613 3019835 ChemDiv3_000045 Cc1ccn(CN2CCN(Cn3ccc(C)n3)C2=S)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C02 compound treatment 164400.0 -8340.0 -0.32 151320.0 -21300.0 -0.8 -0.7938 -0.9208 1183514 ChemDiv3_000046 CC(=O)Oc1ccc(C(=O)c2ccccc2)c(OC(=O)C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C03 compound treatment 141120.0 -31600.0 -1.23 130560.0 -42000.0 -1.58 -1.9835 -0.9922 1699403 ChemDiv3_000047 O=C(NC1(CCC(=O)O1)C(=O)OCc2ccccc2)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C04 compound treatment 144960.0 -27800.0 -1.08 152080.0 -20500.0 -0.77 -1.307 -0.9865 3019836 ChemDiv3_000048 COc1ccc(NC(=S)C)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C05 compound treatment 179640.0 6900.0 0.27 147320.0 -25300.0 -0.95 -0.4818 -0.4886 3019837 ChemDiv3_000049 Clc1ccc(OC(=O)c2ccc(Br)cc2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C06 compound treatment 143600.0 -29100.0 -1.13 136960.0 -35600.0 -1.34 -1.7456 -0.9965 3117579 ChemDiv3_000050 CC(C)N(C(C)C)C(=O)C[n+]1ccc(/C=N/O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C07 compound treatment 145040.0 -27700.0 -1.07 135480.0 -37100.0 -1.39 -1.7453 -0.9918 1112119 ChemDiv3_000051 CC(=O)Oc1ccc(cc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C08 compound treatment 147640.0 -25100.0 -0.97 152200.0 -20400.0 -0.77 -1.2303 -0.9929 1921020 ChemDiv3_000052 CC[n+]1cccc(c1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C09 compound treatment 13040.0 -160000.0 -6.2 10560.0 -162000.0 -6.08 -8.6821 -1.0 1233273 ChemDiv3_000053 CCN1CCN(CC1)c2ccc(Nc3ccnc4cc5ccccc5cc34)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C10 compound treatment 148640.0 -24100.0 -0.94 140040.0 -32600.0 -1.22 -1.5255 -0.9913 3019838 ChemDiv3_000054 NC(=O)N1CCc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C11 compound treatment 12680.0 -160000.0 -6.21 11560.0 -161000.0 -6.04 -8.6655 -0.9999 1021994 ChemDiv3_000055 Oc1ccc(cc1)C2(CCCCC2)c3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C12 compound treatment 140760.0 -32000.0 -1.24 141480.0 -31100.0 -1.17 -1.7035 -0.9995 3019839 ChemDiv3_000056 CC(C)(C)OC(=O)C[n+]1cccc(c1)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C13 compound treatment 142680.0 -30100.0 -1.17 146360.0 -26200.0 -0.99 -1.5213 -0.9965 3117584 ChemDiv3_000057 O=C1CN(C(=O)N1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C14 compound treatment 141800.0 -30900.0 -1.2 137920.0 -34700.0 -1.3 -1.7695 -0.9992 3019840 ChemDiv3_000058 O/N=C/c1cc[n+](CC(=O)N2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C15 compound treatment 142440.0 -30300.0 -1.18 145120.0 -27500.0 -1.03 -1.5608 -0.9979 1320550 ChemDiv3_000059 COC(=O)CCS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)CCC(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C16 compound treatment 140360.0 -32400.0 -1.26 152320.0 -20300.0 -0.76 -1.4268 -0.9712 1778026 ChemDiv3_000060 OCc1c(CO)[n+]([O-])c2ccccc2[n+]1[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C17 compound treatment 138600.0 -34100.0 -1.32 142320.0 -30300.0 -1.14 -1.7405 -0.9971 3019841 ChemDiv3_000061 Cc1ccc(cc1)C(=O)C2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C18 compound treatment 145000.0 -27700.0 -1.08 150280.0 -22300.0 -0.84 -1.3537 -0.9923 1353751 ChemDiv3_000062 Clc1cccc(NCn2c(=O)oc3ccccc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C19 compound treatment 163680.0 -9060.0 -0.35 119880.0 -52700.0 -1.98 -1.6479 -0.8199 1912422 ChemDiv3_000063 CCc1ccc(/N=C/c2c[nH]c3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C20 compound treatment 139960.0 -32800.0 -1.27 125480.0 -47100.0 -1.77 -2.1501 -0.9869 1318161 ChemDiv3_000064 C(N1CCOCCN(Cc2ccccc2)CCOCC1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C21 compound treatment 161680.0 -11100.0 -0.43 157440.0 -15200.0 -0.57 -0.706 -0.9903 1038768 ChemDiv3_000065 CCN(CC)c1ccc2c(C)cc(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C22 compound treatment 154760.0 -18000.0 -0.7 144360.0 -28200.0 -1.06 -1.243 -0.9794 3019842 ChemDiv3_000066 O=C(Oc1ccc(cc1)c2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C23 mock treatment 153960.0 -18800.0 -0.73 152200.0 -20400.0 -0.77 -1.0569 -0.9997 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 C24 mock treatment 161800.0 -10900.0 -0.42 173240.0 631.0 0.02 -0.2834 -0.6666 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D01 compound treatment 165440.0 -7300.0 -0.28 155240.0 -17400.0 -0.65 -0.6612 -0.9303 3117585 ChemDiv3_000067 C(Sc1nnnn1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D02 compound treatment 166240.0 -6500.0 -0.25 172320.0 -289.0 -0.01 -0.186 -0.7368 3117586 ChemDiv3_000068 CC(C)(C)C(/C=C/c1ccc(Cl)cc1Cl)n2nnnc2C(C)(C)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D03 compound treatment 167720.0 -5020.0 -0.19 155880.0 -16700.0 -0.63 -0.5817 -0.8849 1053376 ChemDiv3_000069 OC(=O)C1C(C(C1c2ccccc2)C(=O)O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D04 compound treatment 101960.0 -70800.0 -2.75 82320.0 -90300.0 -3.39 -4.3381 -0.9946 3117587 ChemDiv3_000070 O=C(/C=C/N1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D05 compound treatment 27760.0 -145000.0 -5.63 71680.0 -101000.0 -3.79 -6.6562 -0.9815 3019843 ChemDiv3_000071 c1cncc(c1)c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D06 compound treatment 139120.0 -33600.0 -1.3 153200.0 -19400.0 -0.73 -1.4375 -0.9621 1343691 ChemDiv3_000072 CCN(C)CC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D07 compound treatment 135360.0 -37400.0 -1.45 151320.0 -21300.0 -0.8 -1.5905 -0.9605 1187732 ChemDiv3_000073 COC(=O)NC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D08 compound treatment 12440.0 -160000.0 -6.22 11120.0 -161000.0 -6.06 -8.6837 -0.9999 1355186 ChemDiv3_000074 Nc1ccc(Sc2ccc3ccccc3c2Cl)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D09 compound treatment 132120.0 -40600.0 -1.58 137680.0 -34900.0 -1.31 -2.0414 -0.9958 1016949 ChemDiv3_000075 NC(=N)NC(=N)NCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D10 compound treatment 137120.0 -35600.0 -1.38 157160.0 -15400.0 -0.58 -1.3873 -0.9256 1392304 ChemDiv3_000076 Clc1ccc(cc1)c2nnc(o2)C3CCC(CC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D11 compound treatment 143920.0 -28800.0 -1.12 152640.0 -20000.0 -0.75 -1.3207 -0.9811 1388409 ChemDiv3_000077 S=c1sc2ccccc2n1CN3CCN(Cc4ccccc4)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D12 compound treatment 135760.0 -37000.0 -1.43 131280.0 -41300.0 -1.55 -2.1114 -0.9992 3117588 ChemDiv3_000078 COc1ccc(/C=C/2\CC/C(=C\c3ccc(Cl)cc3)/C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D13 compound treatment 66720.0 -106000.0 -4.11 55400.0 -117000.0 -4.4 -6.0194 -0.9994 1025986 ChemDiv3_000079 Cc1ccccc1NC(=O)c2cc3ccccc3cc2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D14 compound treatment 122520.0 -50200.0 -1.95 132120.0 -40500.0 -1.52 -2.4524 -0.9924 1513086 ChemDiv3_000080 O=C(COc1ccc2ccccc2c1)NS(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D15 compound treatment 151040.0 -21700.0 -0.84 133440.0 -39200.0 -1.47 -1.6349 -0.965 1550944 ChemDiv3_000081 O=C(N1CC(CC1=O)c2ccccc2)c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D16 compound treatment 124920.0 -47800.0 -1.86 125000.0 -47600.0 -1.79 -2.5755 -0.9998 1432699 ChemDiv3_000082 CCOC(=O)c1cccc(n1)C(=O)Nc2nc3ccc(OC)cc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D17 compound treatment 137880.0 -34900.0 -1.35 129120.0 -43500.0 -1.63 -2.1106 -0.9956 1601789 ChemDiv3_000083 Cc1ccc(NC(=O)CC2(CC3CC4CC(C3)C2)C4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D18 compound treatment 133560.0 -39200.0 -1.52 101600.0 -71000.0 -2.67 -2.9594 -0.9646 3019844 ChemDiv3_000084 CC(C)OC(=O)n1c(=S)oc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D19 compound treatment 170640.0 -2100.0 -0.08 144360.0 -28200.0 -1.06 -0.8073 -0.7592 1581559 ChemDiv3_000085 O=C(Oc1ccc(OC(=O)c2ccccc2)cc1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D20 compound treatment 51440.0 -121000.0 -4.71 12920.0 -160000.0 -5.99 -7.5659 -0.9928 3117589 ChemDiv3_000086 O=S(=O)(/C=C/c1ccccc1)N2C=Cc3ccccc3C2c4c[nH]c5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D21 compound treatment 143840.0 -28900.0 -1.12 149520.0 -23100.0 -0.87 -1.4056 -0.9919 1529969 ChemDiv3_000087 Nc1nnc(s1)C(=O)c2ccccc2N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D22 compound treatment 11160.0 -162000.0 -6.27 10560.0 -162000.0 -6.08 -8.7337 -0.9999 1119404 ChemDiv3_000088 CCCC1CCC(CC1)c2ccc(OC(=O)c3cccnc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D23 mock treatment 140920.0 -31800.0 -1.23 146480.0 -26100.0 -0.98 -1.5664 -0.9935 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 D24 mock treatment 147360.0 -25400.0 -0.98 149240.0 -23400.0 -0.88 -1.3165 -0.9983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E01 compound treatment 167400.0 -5340.0 -0.21 166480.0 -6130.0 -0.23 -0.3092 -0.9986 3019845 ChemDiv3_000089 C1OC(OCC2OC(OC12)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E02 compound treatment 148800.0 -23900.0 -0.93 163640.0 -8970.0 -0.34 -0.8948 -0.9057 1616713 ChemDiv3_000090 CCCOc1ccc(N)cc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E03 compound treatment 151960.0 -20800.0 -0.81 145560.0 -27000.0 -1.02 -1.288 -0.9935 3117590 ChemDiv3_000091 COc1ccc(cc1OC)C(=O)CN2Cc3ccccc3C2=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E04 compound treatment 149120.0 -23600.0 -0.92 148200.0 -24400.0 -0.92 -1.2958 -1.0 3019846 ChemDiv3_000092 COc1ccc(NC(=O)C)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E05 compound treatment 152000.0 -20700.0 -0.8 149480.0 -23100.0 -0.87 -1.1828 -0.9993 3019847 ChemDiv3_000093 Nc1nc(cc[n+]1[O-])c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E06 compound treatment 137560.0 -35200.0 -1.36 138920.0 -33700.0 -1.26 -1.8593 -0.9993 3117591 ChemDiv3_000094 O/N=C/c1cc[n+](CC(=O)NC2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E07 compound treatment 164080.0 -8660.0 -0.34 133080.0 -39500.0 -1.48 -1.2866 -0.8458 1701731 ChemDiv3_000095 CCc1ccc(cc1)C(=O)Oc2ccc(C#N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E08 compound treatment 135120.0 -37600.0 -1.46 133400.0 -39200.0 -1.47 -2.0727 -1.0 1069596 ChemDiv3_000096 COC(=O)N1C(C=Cc2ccccc12)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E09 compound treatment 127480.0 -45300.0 -1.76 149600.0 -23000.0 -0.86 -1.8524 -0.9466 3019848 ChemDiv3_000097 N/N=C/c1ccc(cc1)S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E10 compound treatment 151640.0 -21100.0 -0.82 142160.0 -30400.0 -1.14 -1.387 -0.9866 3117592 ChemDiv3_000098 CN1CCN(CC1)C(=O)/C=C(/C)\C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E11 compound treatment 136280.0 -36500.0 -1.41 142160.0 -30400.0 -1.14 -1.8084 -0.9944 1026004 ChemDiv3_000099 COc1ccc2ccccc2c1c3c(OC)ccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E12 compound treatment 142320.0 -30400.0 -1.18 142040.0 -30600.0 -1.15 -1.6459 -0.9999 3019849 ChemDiv3_000100 CC(C)(C)C(=O)C[n+]1cccc(c1)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E13 compound treatment 148280.0 -24500.0 -0.95 141040.0 -31600.0 -1.18 -1.5089 -0.994 1049039 ChemDiv3_000101 CC(=O)N(Nc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E14 compound treatment 136640.0 -36100.0 -1.4 141760.0 -30800.0 -1.16 -1.8091 -0.9955 3117593 ChemDiv3_000102 O/N=C/c1ccc[n+](CC(=O)NC2(CC3CC4CC(C3)C2)C4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E15 compound treatment 130840.0 -41900.0 -1.63 149080.0 -23500.0 -0.88 -1.774 -0.9589 3019850 ChemDiv3_000103 CSc1ccc(cc1)c2ccc(SC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E16 compound treatment 138200.0 -34500.0 -1.34 87120.0 -85500.0 -3.21 -3.2164 -0.925 3019851 ChemDiv3_000104 Nc1ccc(cc1)S(=O)(=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E17 compound treatment 163000.0 -9740.0 -0.38 171920.0 -689.0 -0.03 -0.2855 -0.7537 1913805 ChemDiv3_000105 CC(C)(C)OC(=O)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E18 compound treatment 145880.0 -26900.0 -1.04 148000.0 -24600.0 -0.92 -1.39 -0.9982 1334112 ChemDiv3_000106 Cc1ccc(NCn2c(=O)oc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E19 compound treatment 148320.0 -24400.0 -0.95 133160.0 -39400.0 -1.48 -1.7169 -0.9767 1464160 ChemDiv3_000107 OCCNC(=O)c1cc2ccccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E20 compound treatment 148640.0 -24100.0 -0.94 160400.0 -12200.0 -0.46 -0.9852 -0.9461 1484925 ChemDiv3_000108 CC(NS(=O)(=O)c1ccc(C)cc1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E21 compound treatment 34120.0 -139000.0 -5.38 39840.0 -133000.0 -4.98 -7.3267 -0.9993 3117594 ChemDiv3_000109 [O-][S+]1NN([S+]([O-])NN1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E22 compound treatment 137560.0 -35200.0 -1.36 140680.0 -31900.0 -1.2 -1.8126 -0.9979 1033254 ChemDiv3_000110 COc1cc(NCCCC(C)N)c2ncccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E23 mock treatment 145480.0 -27300.0 -1.06 165280.0 -7330.0 -0.28 -0.9424 -0.8623 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 E24 mock treatment 169800.0 -2940.0 -0.11 186200.0 13600.0 0.51 0.28 0.5357 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F01 compound treatment 202960.0 30200.0 1.17 163880.0 -8730.0 -0.33 0.5975 0.4907 1915982 ChemDiv3_000111 O=C1NC(=O)/C(=C/c2ccccc2)/C(=O)N1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F02 compound treatment 176080.0 3340.0 0.13 157200.0 -15400.0 -0.58 -0.3173 -0.5354 1272580 ChemDiv3_000112 CC(=C)CN1c2ccccc2Sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F03 compound treatment 168440.0 -4300.0 -0.17 145160.0 -27400.0 -1.03 -0.8464 -0.8111 1220799 ChemDiv3_000113 Cc1ccc(Nc2ccc3noc4-c5ccccc5C(=O)c2c43)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F04 compound treatment 179120.0 6380.0 0.25 197040.0 24400.0 0.92 0.8234 0.867 1191611 ChemDiv3_000114 O=c1oc2ccccc2c(Nc3ccccc3)c1CN4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F05 compound treatment 178920.0 6180.0 0.24 186880.0 14300.0 0.54 0.5483 0.9343 1052238 ChemDiv3_000115 COc1ccc(C=C2C(=O)NC(=O)NC2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F06 compound treatment 160240.0 -12500.0 -0.49 193600.0 21000.0 0.79 0.2141 0.2315 1363766 ChemDiv3_000116 Cc1cccc(c1)N(CC(=O)O)CC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F07 compound treatment 39120.0 -134000.0 -5.18 41480.0 -131000.0 -4.92 -7.146 -0.9997 1561715 ChemDiv3_000117 O=C(Nc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F08 compound treatment 95000.0 -77700.0 -3.02 110720.0 -61900.0 -2.32 -3.7753 -0.9917 1160251 ChemDiv3_000118 CCCC1CCC(CC1)c2ccc(OC(=O)c3ccco3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F09 compound treatment 93800.0 -78900.0 -3.06 62040.0 -111000.0 -4.15 -5.1002 -0.9888 1185575 ChemDiv3_000119 Cc1cc(F)ccc1S(=O)(=O)NCC2CC3CCC2C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F10 compound treatment 119200.0 -53500.0 -2.08 128320.0 -44300.0 -1.66 -2.6443 -0.9939 1298807 ChemDiv3_000120 OCC(O)C1OC(Nc2ccc(Cl)cc2)C(O)C1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F11 compound treatment 121160.0 -51600.0 -2.0 126720.0 -45900.0 -1.72 -2.633 -0.9972 1454827 ChemDiv3_000121 CC(C)(c1ccccc1)c2cc(CN3CCOCC3)c(O)c(CN4CCOCC4)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F12 compound treatment 142920.0 -29800.0 -1.16 144120.0 -28500.0 -1.07 -1.5742 -0.9992 1403981 ChemDiv3_000122 COc1ccc2oc(=O)c(cc2c1)c3cnc(C)s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F13 compound treatment 149960.0 -22800.0 -0.88 153680.0 -18900.0 -0.71 -1.1273 -0.9941 3117595 ChemDiv3_000123 O/N=C(\C(=O)c1ccccc1Cl)/n2cncn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F14 compound treatment 128520.0 -44200.0 -1.72 120320.0 -52300.0 -1.96 -2.6009 -0.9978 3117598 ChemDiv3_000124 CC1(C)COP(=S)(OC1)C(Nc2ccc(Cl)cc2)c3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F15 compound treatment 151720.0 -21000.0 -0.82 149960.0 -22600.0 -0.85 -1.1778 -0.9998 1605115 ChemDiv3_000125 Oc1ccccc1c2nsnc2C(=O)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F16 compound treatment 143440.0 -29300.0 -1.14 146200.0 -26400.0 -0.99 -1.5047 -0.9977 1419832 ChemDiv3_000126 O=C(Oc1ccc(cc1)S(=O)(=O)c2ccc(OC(=O)c3cccs3)cc2)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F17 compound treatment 13800.0 -159000.0 -6.17 12800.0 -160000.0 -6.0 -8.6018 -0.9999 1721700 ChemDiv3_000127 COc1cccc(c1)C2(CCCC2)c3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F18 compound treatment 151960.0 -20800.0 -0.81 173720.0 1110.0 0.04 -0.5406 -0.6696 1321397 ChemDiv3_000128 Nc1ncn(CC(O)CO)c2nc(Br)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F19 compound treatment 162200.0 -10500.0 -0.41 134560.0 -38000.0 -1.43 -1.2989 -0.8745 3019915 ChemDiv3_000129 COc1ccc(cc1)C(=O)C[n+]2ccc3n(C)nnc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F20 compound treatment 188120.0 15400.0 0.6 155120.0 -17500.0 -0.66 -0.0422 -0.0475 1406847 ChemDiv3_000130 CCCC1CCC(CC1)c2ccc(OC(=O)c3cccs3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F21 compound treatment 138680.0 -34100.0 -1.32 144680.0 -27900.0 -1.05 -1.6757 -0.9934 1504493 ChemDiv3_000131 CC(=O)N1C(NC(=S)N)C(=O)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F22 compound treatment 169720.0 -3020.0 -0.12 153200.0 -19400.0 -0.73 -0.5979 -0.8104 1667131 ChemDiv3_000132 CCOc1ccc(OC(=O)c2cccnc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F23 mock treatment 156480.0 -16300.0 -0.63 171160.0 -1450.0 -0.05 -0.4846 -0.7652 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 F24 mock treatment 167880.0 -4860.0 -0.19 159840.0 -12800.0 -0.48 -0.4722 -0.9169 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G01 compound treatment 204640.0 31900.0 1.24 204360.0 31800.0 1.19 1.7179 0.9998 1210291 ChemDiv3_000133 CN(C)CCOC(=O)c1ccc2[nH]c3CCSCc3c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G02 compound treatment 162200.0 -10500.0 -0.41 161360.0 -11200.0 -0.42 -0.5877 -0.9999 1432983 ChemDiv3_000134 O=C(CC1(CC2CC3CC(C2)C1)C3)N4CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G03 compound treatment 158000.0 -14700.0 -0.57 152440.0 -20200.0 -0.76 -0.9397 -0.9904 3019916 ChemDiv3_000135 CC(Cc1ccccc1)[n+]2cc(N)on2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G04 compound treatment 103760.0 -69000.0 -2.68 43880.0 -129000.0 -4.83 -5.3089 -0.9612 1091968 ChemDiv3_000136 Nc1ccc(Br)cc1C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G05 compound treatment 13760.0 -159000.0 -6.17 12920.0 -160000.0 -5.99 -8.5997 -0.9999 1446265 ChemDiv3_000137 CC(=O)Oc1ccc2ccc3ccc(OC(=O)C)c4ccc1c2c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G06 compound treatment 179360.0 6620.0 0.26 150600.0 -22000.0 -0.83 -0.4025 -0.4653 3019918 ChemDiv3_000138 O/N=C/c1ccc[n+](CC(=O)NCc2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G07 compound treatment 140960.0 -31800.0 -1.23 166480.0 -6130.0 -0.23 -1.0346 -0.8248 3117599 ChemDiv3_000139 CC1CCC/C(=C/c2ccc(Cl)cc2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G08 compound treatment 116480.0 -56300.0 -2.18 123480.0 -49100.0 -1.84 -2.8474 -0.9965 1662647 ChemDiv3_000140 CCOC(=O)NC(=S)Nc1ccc(NC(=O)c2cc(Cl)ccc2O)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G09 compound treatment 150920.0 -21800.0 -0.85 139320.0 -33300.0 -1.25 -1.4821 -0.982 1320817 ChemDiv3_000141 CCN(CC)C(=O)N1CCN(CCC#N)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G10 compound treatment 155600.0 -17100.0 -0.67 151360.0 -21200.0 -0.8 -1.0342 -0.9959 1913999 ChemDiv3_000142 CC(Cc1c[nH]c2ccccc12)NC(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G11 compound treatment 140800.0 -31900.0 -1.24 158560.0 -14000.0 -0.53 -1.2491 -0.9275 3117600 ChemDiv3_000143 S=c1nc(oc2CCCCc21)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G12 compound treatment 146200.0 -26500.0 -1.03 158200.0 -14400.0 -0.54 -1.1105 -0.9548 3019921 ChemDiv3_000144 CC(C)(C)C(=O)C[n+]1ccc(cc1)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G13 compound treatment 140200.0 -32500.0 -1.26 149680.0 -22900.0 -0.86 -1.5013 -0.9825 1032623 ChemDiv3_000145 O=C(N(Nc1ccccc1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G14 compound treatment 135320.0 -37400.0 -1.45 156440.0 -16200.0 -0.61 -1.4558 -0.9251 3117601 ChemDiv3_000146 OC(=O)c1ccc(NC(=O)C[n+]2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G15 compound treatment 151520.0 -21200.0 -0.82 138720.0 -33900.0 -1.27 -1.4816 -0.9778 3117602 ChemDiv3_000147 CSc1ccc(Sc2ccc(SC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G16 compound treatment 129720.0 -43000.0 -1.67 138080.0 -34500.0 -1.3 -2.0966 -0.9922 1075919 ChemDiv3_000148 Clc1ccc(OCC(=O)NCCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G17 compound treatment 145160.0 -27600.0 -1.07 132360.0 -40200.0 -1.51 -1.8248 -0.9857 1146554 ChemDiv3_000149 OCC1(C(=O)c2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G18 compound treatment 139280.0 -33500.0 -1.3 145680.0 -26900.0 -1.01 -1.6327 -0.9923 1723737 ChemDiv3_000150 NC(=S)c1cc2ccccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G19 compound treatment 161960.0 -10800.0 -0.42 160800.0 -11800.0 -0.44 -0.6092 -0.9996 1601550 ChemDiv3_000151 COc1ccc(C2C(=O)c3ccccc3C2=O)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G20 compound treatment 145800.0 -26900.0 -1.05 143080.0 -29500.0 -1.11 -1.5228 -0.9996 1302822 ChemDiv3_000152 Cc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G21 compound treatment 159160.0 -13600.0 -0.53 178280.0 5670.0 0.21 -0.2221 -0.3908 3019795 ChemDiv3_000153 S=C1NN=C(C(N1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G22 compound treatment 143840.0 -28900.0 -1.12 134480.0 -38100.0 -1.43 -1.8048 -0.9927 1416806 ChemDiv3_000154 Nc1ccc(cc1)C(=O)Nc2ccc(cc2N)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G23 mock treatment 147920.0 -24800.0 -0.96 150360.0 -22200.0 -0.84 -1.2714 -0.9975 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 G24 mock treatment 175120.0 2380.0 0.09 152440.0 -20200.0 -0.76 -0.47 -0.6163 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H01 compound treatment 174440.0 1700.0 0.07 194680.0 22100.0 0.83 0.6324 0.761 1123126 ChemDiv3_000155 C(CN1CCOCC1)Sc2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H02 compound treatment 183640.0 10900.0 0.42 167880.0 -4730.0 -0.18 0.1736 0.3784 3019817 ChemDiv3_000156 CCOC(=O)c1c(C)c(C)sc1/N=C/c2ccc(cc2)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H03 compound treatment 184360.0 11600.0 0.45 205160.0 32600.0 1.22 1.1827 0.9082 3117603 ChemDiv3_000157 CCOC(=O)c1c(C)c(C)sc1/N=C/c2ccccc2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H04 compound treatment 151920.0 -20800.0 -0.81 166160.0 -6450.0 -0.24 -0.7424 -0.8803 3019818 ChemDiv3_000158 COc1ccc(cc1)N(C(=O)/C=C/c2ccc(OC)c(OC)c2)C3=CC4CCC(C3)N4C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H05 compound treatment 170880.0 -1860.0 -0.07 195840.0 23200.0 0.87 0.5655 0.6464 1020750 ChemDiv3_000159 NC(=O)c1ccc[n+](CC(=O)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H06 compound treatment 151600.0 -21100.0 -0.82 161320.0 -11300.0 -0.42 -0.8796 -0.9528 1221336 ChemDiv3_000160 Cc1ccc(OC(=O)c2ccccc2)c(c1)n3nc4ccccc4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H07 compound treatment 133960.0 -38800.0 -1.5 134640.0 -38000.0 -1.43 -2.0716 -0.9996 1171342 ChemDiv3_000161 COC(=O)NC(=S)Nc1ccc(Oc2ccc(Cl)cc2Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H08 compound treatment 150800.0 -21900.0 -0.85 155120.0 -17500.0 -0.66 -1.0661 -0.9917 1054931 ChemDiv3_000162 O=C(Oc1ccc(cc1)c2ccccc2)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H09 compound treatment 157960.0 -14800.0 -0.57 157440.0 -15200.0 -0.57 -0.8081 -1.0 1080023 ChemDiv3_000163 O=C1C2C3CC(C=C3)C2C(=O)N1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H10 compound treatment 133880.0 -38900.0 -1.51 141600.0 -31000.0 -1.16 -1.8891 -0.9918 1270809 ChemDiv3_000164 Cc1ccccc1C(=O)N2N=C(CC2c3nc4ccccc4[nH]3)c5ccc(Br)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H11 compound treatment 160080.0 -12700.0 -0.49 159680.0 -12900.0 -0.49 -0.6905 -1.0 1111851 ChemDiv3_000165 OCc1nc2cc3ccccc3cc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H12 compound treatment 154080.0 -18700.0 -0.72 178640.0 6030.0 0.23 -0.3519 -0.4639 3117604 ChemDiv3_000166 O=C1N(C(=O)c2cc(ccc12)c3ncc(o3)c4ccccc4)c5ncn[nH]5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H13 compound treatment 190720.0 18000.0 0.7 206680.0 34100.0 1.28 1.3975 0.9594 3019820 ChemDiv3_000167 Oc1ccccc1/C=N/n2c3ccccc3c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H14 compound treatment 161120.0 -11600.0 -0.45 152400.0 -20200.0 -0.76 -0.8551 -0.9691 3117605 ChemDiv3_000168 C/N=C(\C)/c1c(O)c2ccccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H15 compound treatment 14560.0 -158000.0 -6.14 14840.0 -158000.0 -5.92 -8.5268 -0.9998 1279829 ChemDiv3_000169 Oc1ccccc1C2CCCCC2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H16 compound treatment 152160.0 -20600.0 -0.8 156600.0 -16000.0 -0.6 -0.9895 -0.9902 1311336 ChemDiv3_000170 Nc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3cccc(N)c3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H17 compound treatment 31280.0 -141000.0 -5.49 31320.0 -141000.0 -5.3 -7.6307 -0.9999 1341633 ChemDiv3_000171 Cc1cc(C)c2ccc(NN)nc2c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H18 compound treatment 143960.0 -28800.0 -1.12 156280.0 -16300.0 -0.61 -1.223 -0.9601 3117606 ChemDiv3_000172 CC(=O)Nc1c(C)nn(c1O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H19 compound treatment 132280.0 -40500.0 -1.57 128720.0 -43900.0 -1.65 -2.2748 -0.9997 3019822 ChemDiv3_000173 COc1ccc2nc(C)cc(S)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H20 compound treatment 151640.0 -21100.0 -0.82 141560.0 -31000.0 -1.17 -1.4029 -0.9851 1016095 ChemDiv3_000174 COC(=O)c1cccc(n1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H21 compound treatment 139640.0 -33100.0 -1.28 138640.0 -34000.0 -1.27 -1.8096 -1.0 1229822 ChemDiv3_000175 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)Nc2ccc(I)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H22 compound treatment 145720.0 -27000.0 -1.05 146560.0 -26000.0 -0.98 -1.4326 -0.9994 1484239 ChemDiv3_000176 CC(C)OC(=O)c1cccc(n1)C(=O)Nc2ccc(NC(=O)C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H23 mock treatment 164640.0 -8100.0 -0.31 161320.0 -11300.0 -0.42 -0.5218 -0.9892 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 H24 mock treatment 156360.0 -16400.0 -0.64 155960.0 -16600.0 -0.62 -0.8912 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I01 compound treatment 165680.0 -7060.0 -0.27 174400.0 1790.0 0.07 -0.1462 -0.5182 1528297 ChemDiv3_000177 CCN(CC)C(=O)COc1ccc(C)nc1CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I02 compound treatment 194000.0 21300.0 0.82 188520.0 15900.0 0.6 1.0056 0.9874 1726229 ChemDiv3_000178 O=C(NC1CCCCC1)NC2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I03 compound treatment 161520.0 -11200.0 -0.44 166960.0 -5650.0 -0.21 -0.4577 -0.9453 1695838 ChemDiv3_000179 OC(=O)c1ccc2C(=O)c3ccccc3S(=O)(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I04 compound treatment 183320.0 10600.0 0.41 219160.0 46600.0 1.75 1.5257 0.8501 1706757 ChemDiv3_000180 CCCN(CCC)C(=O)Cn1ccc(=N)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I05 compound treatment 179800.0 7060.0 0.27 174680.0 2070.0 0.08 0.2487 0.8733 3019863 ChemDiv3_000181 OC(=O)c1ccc(cc1)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I06 compound treatment 157840.0 -14900.0 -0.58 148720.0 -23900.0 -0.9 -1.0428 -0.9775 3117607 ChemDiv3_000182 C[N+](C)(CCOc1ccccc1)Cc2ccccc2.OC(=O)c1cc2ccccc2c(Br)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I07 compound treatment 160800.0 -11900.0 -0.46 196360.0 23800.0 0.89 0.3027 0.3014 1103446 ChemDiv3_000183 OC(=O)C(Cc1ccccc1)NC=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I08 compound treatment 164360.0 -8380.0 -0.33 175360.0 2750.0 0.1 -0.1569 -0.4599 3019864 ChemDiv3_000184 NC(=S)/N=C/1\CCCCC1=C2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I09 compound treatment 154320.0 -18400.0 -0.71 157200.0 -15400.0 -0.58 -0.9143 -0.9945 3117608 ChemDiv3_000185 Clc1ccc(cc1)S(=O)(=O)/N=C/2\SCCN2S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I10 compound treatment 211600.0 38900.0 1.51 161440.0 -11200.0 -0.42 0.7698 0.4919 3019865 ChemDiv3_000186 NC(=O)c1ccc[n+](CC(=O)N(CC=C)CC=C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I11 compound treatment 206880.0 34100.0 1.32 177720.0 5110.0 0.19 1.0723 0.8012 1008424 ChemDiv3_000187 Nc1ccc(Sc2ccc(N)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I12 compound treatment 174880.0 2140.0 0.08 181040.0 8430.0 0.32 0.2825 0.8634 3117609 ChemDiv3_000188 CC(C)(C)OC(=O)C[n+]1ccc(cc1)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I13 compound treatment 172200.0 -540.0 -0.02 178720.0 6110.0 0.23 0.1474 0.6398 1590292 ChemDiv3_000189 Cc1ccc(cc1)C(=O)Oc2cc(C)cc(OC(=O)c3ccc(C)cc3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I14 compound treatment 149280.0 -23500.0 -0.91 162480.0 -10100.0 -0.38 -0.9125 -0.925 3019866 ChemDiv3_000190 Brc1ccc2[n+](C/C=C/c3ccccc3)cccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I15 compound treatment 150600.0 -22100.0 -0.86 181800.0 9190.0 0.34 -0.3635 -0.3927 2121292 ChemDiv3_000191 Clc1ccc(cc1Cl)S(=O)(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I16 compound treatment 170800.0 -1940.0 -0.08 159280.0 -13300.0 -0.5 -0.407 -0.8044 1483300 ChemDiv3_000192 COc1ccc(Cl)c(NCCC(=O)O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I17 compound treatment 161640.0 -11100.0 -0.43 176520.0 3910.0 0.15 -0.2007 -0.4412 1243544 ChemDiv3_000193 CCOc1ccc(cc1OC)C2(CC(=O)Nc3ccccc3)C(=O)c4ccccc4C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I18 compound treatment 190360.0 17600.0 0.68 176040.0 3430.0 0.13 0.5745 0.8258 1632789 ChemDiv3_000194 O=C(Nc1cccc2ccccc12)c3cc4ccccc4oc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I19 compound treatment 156640.0 -16100.0 -0.62 201080.0 28500.0 1.07 0.3139 0.2536 1020326 ChemDiv3_000195 CCOC(=O)C1=C(O)c2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I20 compound treatment 154840.0 -17900.0 -0.69 156920.0 -15700.0 -0.59 -0.9075 -0.9966 1160580 ChemDiv3_000196 OC(=O)C(Cc1cnc[nH]1)N2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I21 compound treatment 150920.0 -21800.0 -0.85 182240.0 9630.0 0.36 -0.343 -0.3727 1223725 ChemDiv3_000197 OC(=O)CC1(CC2CC3C1)CC(CC(=O)O)(C2)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I22 compound treatment 197600.0 24900.0 0.96 158000.0 -14600.0 -0.55 0.2944 0.2653 3019868 ChemDiv3_000198 OC(=O)c1ccc(C(=O)O)c(c1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I23 mock treatment 159840.0 -12900.0 -0.5 196680.0 24100.0 0.9 0.2849 0.2758 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 I24 mock treatment 180120.0 7380.0 0.29 156080.0 -16500.0 -0.62 -0.2362 -0.3457 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J01 compound treatment 187200.0 14500.0 0.56 210800.0 38200.0 1.43 1.4103 0.9162 3117610 ChemDiv3_000199 N/N=C(\C(=O)O)/c1ccccc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J02 compound treatment 193040.0 20300.0 0.79 170760.0 -1850.0 -0.07 0.5079 0.6423 3019869 ChemDiv3_000200 O=C(C[n+]1ccc(C#N)cc1)c2ccc(NC(=O)c3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J03 compound treatment 185160.0 12400.0 0.48 220480.0 47900.0 1.8 1.6112 0.8661 3117612 ChemDiv3_000201 O=C(/C=C/c1c[nH]c2ccccc12)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J04 compound treatment 113600.0 -59100.0 -2.29 105560.0 -67000.0 -2.52 -3.402 -0.9989 1170304 ChemDiv3_000202 OC(=O)CCNc1cc(Cl)ccc1Oc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J05 compound treatment 178000.0 5260.0 0.2 282480.0 110000.0 4.12 3.0602 0.7412 3019870 ChemDiv3_000203 O=C(C[n+]1cccc(NC(=O)c2ccccc2)c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J06 compound treatment 160160.0 -12600.0 -0.49 161800.0 -10800.0 -0.41 -0.632 -0.9958 1618034 ChemDiv3_000204 COc1ccc(cc1)N2C(=O)C3CC=CC(C)C3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J07 compound treatment 221080.0 48300.0 1.88 220800.0 48200.0 1.81 2.6052 0.9998 3117613 ChemDiv3_000205 CCn1c(C)[n+](CC)c2cc(ccc12)S(=O)(=O)NC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J08 compound treatment 17000.0 -156000.0 -6.04 18840.0 -154000.0 -5.77 -8.3537 -0.9997 1082227 ChemDiv3_000206 C(CSc1nc2ccccc2[nH]1)Sc3nc4ccccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J09 compound treatment 191000.0 18300.0 0.71 265280.0 92700.0 3.48 2.9604 0.834 3019871 ChemDiv3_000207 Cc1ccc(cc1C)C(=O)c2ccc(C)c(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J10 compound treatment 200960.0 28200.0 1.09 211240.0 38600.0 1.45 1.7995 0.9904 1921766 ChemDiv3_000208 CC(/N=C/c1ccccc1O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J11 compound treatment 179400.0 6660.0 0.26 220400.0 47800.0 1.79 1.4511 0.8007 1340958 ChemDiv3_000209 CCN(CC)CCSc1nnc2c3ccccc3n(CC(=O)N)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J12 compound treatment 164520.0 -8220.0 -0.32 151040.0 -21600.0 -0.81 -0.7979 -0.9171 1421356 ChemDiv3_000210 O=C(Nc1nc(cs1)c2ccccc2)c3ccc(cc3)S(=O)(=O)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J13 compound treatment 177880.0 5140.0 0.2 196920.0 24300.0 0.91 0.7862 0.8418 3019898 ChemDiv3_000211 Oc1ccccc1/C=N/c2cccc(\N=C\c3ccccc3O)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J14 compound treatment 167480.0 -5260.0 -0.2 238000.0 65400.0 2.45 1.5911 0.6461 3117614 ChemDiv3_000212 Clc1ccc2[nH]c(=O)nc(c3ccccc3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J15 compound treatment 14640.0 -158000.0 -6.13 16960.0 -156000.0 -5.84 -8.4684 -0.9997 1122932 ChemDiv3_000213 Oc1cc(cc(c1)C2CCCCC2)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J16 compound treatment 153720.0 -19000.0 -0.74 190680.0 18100.0 0.68 -0.0422 -0.0421 3117615 ChemDiv3_000214 CC(=O)NC1=NN(C(=O)C)C(C)(CS(=O)(=O)c2ccc(C)cc2)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J17 compound treatment 71040.0 -102000.0 -3.95 130400.0 -42200.0 -1.58 -3.9104 -0.9196 1730515 ChemDiv3_000215 CNc1ccc2cccc(Oc3ccc4cccc(O)c4n3)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J18 compound treatment 157800.0 -14900.0 -0.58 158600.0 -14000.0 -0.53 -0.7817 -0.9988 1591676 ChemDiv3_000216 Nc1cccc(NC(=O)CCC(=O)O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J19 compound treatment 209680.0 36900.0 1.43 186280.0 13700.0 0.51 1.3763 0.9041 3117616 ChemDiv3_000217 CC1(C)CC(CC(C)(C)N1)/N=C/c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J20 compound treatment 161320.0 -11400.0 -0.44 155160.0 -17400.0 -0.65 -0.7764 -0.9819 1528923 ChemDiv3_000218 CC(C)OC(=O)c1cccc(n1)C(=O)OC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J21 compound treatment 185240.0 12500.0 0.49 168560.0 -4050.0 -0.15 0.2355 0.4634 1320476 ChemDiv3_000219 OC(=O)CC(N1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J22 compound treatment 161880.0 -10900.0 -0.42 182560.0 9950.0 0.37 -0.0339 -0.0601 1009844 ChemDiv3_000220 Nc1cc(ccc1O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J23 mock treatment 169440.0 -3300.0 -0.13 208000.0 35400.0 1.33 0.8487 0.636 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 J24 mock treatment 187160.0 14400.0 0.56 168840.0 -3770.0 -0.14 0.2956 0.5122 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K01 compound treatment 114000.0 -58700.0 -2.28 136840.0 -35800.0 -1.34 -2.5609 -0.9681 1273679 ChemDiv3_000221 CCN(CC)CCOc1ccc2nc(sc2c1)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K02 compound treatment 152920.0 -19800.0 -0.77 165640.0 -6970.0 -0.26 -0.7287 -0.8971 1202625 ChemDiv3_000222 OCCC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K03 compound treatment 163640.0 -9100.0 -0.35 163920.0 -8690.0 -0.33 -0.4803 -0.9992 1450413 ChemDiv3_000223 CS(=O)(=O)CS(=O)(=O)C1=C(C2CCN1CC2)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K04 compound treatment 200960.0 28200.0 1.09 192000.0 19400.0 0.73 1.2889 0.9803 1353143 ChemDiv3_000224 CC(C)N(C(C)C)C(=O)Cn1ccc(=N)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K05 compound treatment 159880.0 -12900.0 -0.5 155360.0 -17200.0 -0.65 -0.8106 -0.9917 3117617 ChemDiv3_000225 CCCCc1ccc(CC(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K06 compound treatment 170480.0 -2260.0 -0.09 159400.0 -13200.0 -0.5 -0.4126 -0.8195 3019901 ChemDiv3_000226 CC[n+]1cccc(c1)c2nc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K07 compound treatment 161920.0 -10800.0 -0.42 160880.0 -11700.0 -0.44 -0.6081 -0.9997 1058991 ChemDiv3_000227 CCc1ccc(CC(=S)N2CCOCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K08 compound treatment 163880.0 -8860.0 -0.34 181000.0 8390.0 0.31 -0.0204 -0.0437 1049850 ChemDiv3_000228 C(N1CCN(CC1)c2ccccc2)N3CCN(CC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K09 compound treatment 162880.0 -9860.0 -0.38 190360.0 17800.0 0.67 0.2006 0.2611 1529951 ChemDiv3_000229 COc1ccc2N(C)C(=O)C(C)(CC#N)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K10 compound treatment 154880.0 -17900.0 -0.69 187840.0 15200.0 0.57 -0.0858 -0.0955 3117618 ChemDiv3_000230 NC(=O)c1cc[n+](CC(=O)N(CC=C)CC=C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K11 compound treatment 183000.0 10300.0 0.4 174760.0 2150.0 0.08 0.3386 0.8335 1049796 ChemDiv3_000231 C[n+]1ccc(cc1)c2cc[n+](C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K12 compound treatment 164080.0 -8660.0 -0.34 161360.0 -11200.0 -0.42 -0.5361 -0.9936 3117619 ChemDiv3_000232 O/N=C/c1ccc[n+](C/C=C/c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K13 compound treatment 174960.0 2220.0 0.09 206640.0 34000.0 1.28 0.9641 0.7531 1377603 ChemDiv3_000233 Cc1cccc(NC(=O)c2cccc(c2)C(=O)Nc3cccc(C)c3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K14 compound treatment 163440.0 -9300.0 -0.36 178360.0 5750.0 0.22 -0.1025 -0.2438 3117620 ChemDiv3_000234 NC(=O)NC(=O)C[n+]1ccc(/C=N/O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K15 compound treatment 176520.0 3780.0 0.15 175920.0 3310.0 0.12 0.1916 0.9966 1086380 ChemDiv3_000235 Brc1ccc(cc1)S(=O)(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K16 compound treatment 153760.0 -19000.0 -0.74 180200.0 7590.0 0.28 -0.3193 -0.4043 3117621 ChemDiv3_000236 OC(=O)CN(CCc1ccccc1)CC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K17 compound treatment 45200.0 -128000.0 -4.95 77240.0 -95400.0 -3.58 -6.0302 -0.9874 1677145 ChemDiv3_000237 O=C1C(C(C2C(=O)c3ccccc3C2=O)c4ccccc4)C(=O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K18 compound treatment 157240.0 -15500.0 -0.6 182040.0 9430.0 0.35 -0.175 -0.2507 1190677 ChemDiv3_000238 CCN(CC)c1ccc2cc(C(=O)Nc3ccccc3)c(=N)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K19 compound treatment 182680.0 9940.0 0.39 163920.0 -8690.0 -0.33 0.0421 0.0834 3019902 ChemDiv3_000239 CCC(=O)c1ccc2cc(OC)ccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K20 compound treatment 152360.0 -20400.0 -0.79 186440.0 13800.0 0.52 -0.1921 -0.2031 1231229 ChemDiv3_000240 CCCCC(N1C(=O)c2ccccc2C1=O)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K21 compound treatment 12160.0 -161000.0 -6.23 115440.0 -57200.0 -2.15 -5.9229 -0.8988 1111942 ChemDiv3_000241 CN(C)CCC(=O)c1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K22 compound treatment 155800.0 -16900.0 -0.66 208520.0 35900.0 1.35 0.4883 0.3256 3019922 ChemDiv3_000242 Cc1cc(NC(=O)c2ccc(N)cc2)c(N)cc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K23 mock treatment 204920.0 32200.0 1.25 162280.0 -10300.0 -0.39 0.6088 0.4656 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 K24 mock treatment 184480.0 11700.0 0.46 191840.0 19200.0 0.72 0.8325 0.9754 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L01 compound treatment 176320.0 3580.0 0.14 208080.0 35500.0 1.33 1.0396 0.7767 3117622 ChemDiv3_000243 CC(=O)Nc1ccc(NC(=O)/C=N/O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L02 compound treatment 185560.0 12800.0 0.5 203560.0 31000.0 1.16 1.1731 0.9284 3117623 ChemDiv3_000244 O=C(C[n+]1cccc(c1)C(=O)Nc2ccccc2)c3ccc(cc3)N4C(=O)c5ccccc5C4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L03 compound treatment 189200.0 16500.0 0.64 196520.0 23900.0 0.9 1.0862 0.9861 3019923 ChemDiv3_000245 CC1(C)CC(CC(C)(C)N1)NC(=O)/C=C/C(=O)NC2CC(C)(C)NC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L04 compound treatment 166240.0 -6500.0 -0.25 166400.0 -6210.0 -0.23 -0.3431 -0.9992 1260714 ChemDiv3_000246 CC(C)(C)c1ccc(O)c(CN2CCN(CC2)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L05 compound treatment 189880.0 17100.0 0.67 220200.0 47600.0 1.79 1.7333 0.9094 3019924 ChemDiv3_000247 CC(C)N1C(=O)N(C(=CC1(C)C)C)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L06 compound treatment 171040.0 -1700.0 -0.07 207800.0 35200.0 1.32 0.8873 0.671 1635573 ChemDiv3_000248 COc1ccc(cc1CN2CCOCC2)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L07 compound treatment 159920.0 -12800.0 -0.5 160000.0 -12600.0 -0.47 -0.6864 -0.9997 1417227 ChemDiv3_000249 C1CN(CCO1)c2ccc(Nc3ccnc4cc5ccccc5cc34)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L08 compound treatment 188560.0 15800.0 0.61 189920.0 17300.0 0.65 0.8935 0.9996 3019925 ChemDiv3_000250 Brc1ccc(cc1)N(CN2C(=O)c3ccccc3C2=O)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L09 compound treatment 177880.0 5140.0 0.2 187240.0 14600.0 0.55 0.5293 0.906 1196316 ChemDiv3_000251 COc1ccc(cc1)C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccnc3OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L10 compound treatment 161200.0 -11500.0 -0.45 180000.0 7390.0 0.28 -0.1205 -0.2287 1401655 ChemDiv3_000252 CCSC1=C(C#N)C(C(=C(C)N1)C(=O)Nc2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L11 compound treatment 164480.0 -8260.0 -0.32 173920.0 1310.0 0.05 -0.1918 -0.5916 1010418 ChemDiv3_000253 Oc1ccc(cc1)S(=O)(=O)c2ccc(O)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L12 compound treatment 179440.0 6700.0 0.26 214440.0 41800.0 1.57 1.294 0.8131 1538510 ChemDiv3_000254 CCOC(=O)n1c(=O)oc2cc(Cl)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L13 compound treatment 173600.0 860.0 0.03 159200.0 -13400.0 -0.5 -0.3323 -0.6588 1642025 ChemDiv3_000255 CCOC(=O)Nc1cc(=O)c2ccccc2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L14 compound treatment 172600.0 -140.0 -0.01 197400.0 24800.0 0.93 0.6541 0.703 1641183 ChemDiv3_000256 O=C(COC(=O)c1cc2ccccc2oc1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L15 compound treatment 151200.0 -21500.0 -0.84 200720.0 28100.0 1.06 0.1551 0.1152 3019926 ChemDiv3_000257 O/N=C(\c1ccccc1)/C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L16 compound treatment 14880.0 -158000.0 -6.13 21600.0 -151000.0 -5.67 -8.3386 -0.9992 3117624 ChemDiv3_000258 CC[n+]1c(/C=C\2/CC(C)(C)CC(=C2)C)oc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L17 compound treatment 105520.0 -67200.0 -2.61 161640.0 -11000.0 -0.41 -2.1353 -0.8087 1920076 ChemDiv3_000259 Cc1cc(C)c2ccc(/C=N/O)nc2c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L18 compound treatment 67280.0 -105000.0 -4.09 130960.0 -41600.0 -1.56 -3.9987 -0.9129 3117625 ChemDiv3_000260 CC[n+]1c(/C=C/2\CC(C)CC(=C2)C)sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L19 compound treatment 164680.0 -8060.0 -0.31 192520.0 19900.0 0.75 0.3073 0.3793 1315100 ChemDiv3_000261 CSc1nc2ccccc2n1CN(C)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L20 compound treatment 166080.0 -6660.0 -0.26 179920.0 7310.0 0.27 0.0113 0.03 1305784 ChemDiv3_000262 COC(=O)c1cccc(n1)C(=O)Oc2ccc(OC(=O)c3cccc(n3)C(=O)OC)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L21 compound treatment 10680.0 -162000.0 -6.29 13560.0 -159000.0 -5.97 -8.6673 -0.9997 1433025 ChemDiv3_000263 Cc1cc(cc(C)c1N)C2(CCCCC2)c3cc(C)c(N)c(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L22 compound treatment 163560.0 -9180.0 -0.36 169720.0 -2890.0 -0.11 -0.3285 -0.8824 1464584 ChemDiv3_000264 CN(C)c1ccc(cc1)C(O)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L23 mock treatment 177480.0 4740.0 0.18 174440.0 1830.0 0.07 0.1786 0.9099 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 L24 mock treatment 183360.0 10600.0 0.41 189000.0 16400.0 0.62 0.7264 0.981 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M01 compound treatment 151880.0 -20900.0 -0.81 139280.0 -33300.0 -1.25 -1.4568 -0.9778 1660133 ChemDiv3_000265 CC1=CC(=O)OC1Cc2ccc3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M02 compound treatment 174840.0 2100.0 0.08 153160.0 -19400.0 -0.73 -0.4585 -0.6243 1710588 ChemDiv3_000266 CC(=O)Nc1nc(cs1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M03 compound treatment 175800.0 3060.0 0.12 186400.0 13800.0 0.52 0.45 0.8473 3117626 ChemDiv3_000267 C/N=C\1/S/C(=C\c2cn(CC(=O)O)c3ccccc23)/C(=O)N1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M04 compound treatment 184400.0 11700.0 0.45 170680.0 -1930.0 -0.07 0.2687 0.5865 3019928 ChemDiv3_000268 CC(C)(C)NC(=O)C[n+]1cccc(/C=N/O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M05 compound treatment 174880.0 2140.0 0.08 163720.0 -8890.0 -0.33 -0.1772 -0.5154 3117629 ChemDiv3_000269 CC(=O)OC1CCC(CC1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M06 compound treatment 14800.0 -158000.0 -6.13 18120.0 -154000.0 -5.8 -8.4332 -0.9996 3019929 ChemDiv3_000270 CC(=O)Nc1sc2CCCCc2c1SC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M07 compound treatment 131800.0 -40900.0 -1.59 162400.0 -10200.0 -0.38 -1.3942 -0.8532 3117630 ChemDiv3_000271 CCC1(CC)C(=[N+](C)c2ccccc21)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M08 compound treatment 174080.0 1340.0 0.05 181400.0 8790.0 0.33 0.2701 0.8086 1692026 ChemDiv3_000272 CC1(C)CC(CC(C)(C)N1)NC(=O)c2ccccc2C(=O)NC3CC(C)(C)NC(C)(C)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M09 compound treatment 141720.0 -31000.0 -1.2 160800.0 -11800.0 -0.44 -1.1645 -0.9079 3019876 ChemDiv3_000273 CC[n+]1c(C)sc(c1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M10 compound treatment 180880.0 8140.0 0.32 191640.0 19000.0 0.71 0.7284 0.9327 3117631 ChemDiv3_000274 NC(=O)c1ccc[n+](CC(=O)N2CCCCC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M11 compound treatment 167200.0 -5540.0 -0.21 199680.0 27100.0 1.02 0.5664 0.5454 1141301 ChemDiv3_000275 COC(=O)Nc1ccc(cc1)S(=O)(=O)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M12 compound treatment 193360.0 20600.0 0.8 197680.0 25100.0 0.94 1.2311 0.9967 3117632 ChemDiv3_000276 O/N=C/c1cc[n+](CCC(=O)NCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M13 compound treatment 121560.0 -51200.0 -1.99 140720.0 -31900.0 -1.2 -2.2505 -0.9706 3019878 ChemDiv3_000277 Cc1cccc(NC(=O)/C=C/c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M14 compound treatment 162800.0 -9940.0 -0.39 205640.0 33000.0 1.24 0.6039 0.4651 3117633 ChemDiv3_000278 OC(=O)c1ccccc1NC(=O)C[n+]2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M15 compound treatment 184040.0 11300.0 0.44 189880.0 17300.0 0.65 0.7684 0.9819 1048436 ChemDiv3_000279 O=C(Nc1ccccc1)C2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M16 compound treatment 173000.0 260.0 0.01 192640.0 20000.0 0.75 0.5387 0.7165 1410422 ChemDiv3_000280 CCNc1c(N)c(=O)oc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M17 compound treatment 167000.0 -5740.0 -0.22 179040.0 6430.0 0.24 0.0132 0.0402 3019903 ChemDiv3_000281 Nc1nonc1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M18 compound treatment 162000.0 -10700.0 -0.42 180640.0 8030.0 0.3 -0.0815 -0.1585 3019904 ChemDiv3_000282 CC(C)C1=CCC(C)/C(=C\c2ccc(Cl)cc2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M19 compound treatment 12680.0 -160000.0 -6.21 16000.0 -157000.0 -5.88 -8.5476 -0.9996 1010017 ChemDiv3_000283 O=C1C=CC(=O)N1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M20 compound treatment 178040.0 5300.0 0.21 152920.0 -19700.0 -0.74 -0.3771 -0.4916 1922526 ChemDiv3_000284 Brc1ccccc1c2nc3ccccc3c4nc5ccccc5n24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M21 compound treatment 51440.0 -121000.0 -4.71 39360.0 -133000.0 -5.0 -6.8643 -0.9995 1409537 ChemDiv3_000285 Nc1ccc(cc1)C(=O)CC(=O)Nc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M22 compound treatment 130520.0 -42200.0 -1.64 150640.0 -22000.0 -0.82 -1.7414 -0.9495 1104285 ChemDiv3_000286 OC(=O)c1cc2ccc3cccc4ccc(c1)c2c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M23 mock treatment 185760.0 13000.0 0.51 200040.0 27400.0 1.03 1.0852 0.9463 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 M24 mock treatment 184280.0 11500.0 0.45 181960.0 9350.0 0.35 0.5648 0.9927 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N01 compound treatment 178120.0 5380.0 0.21 189360.0 16800.0 0.63 0.5922 0.8939 3019905 ChemDiv3_000287 C/C(=C/C(=O)O)/C=C/c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N02 compound treatment 94920.0 -77800.0 -3.02 111560.0 -61000.0 -2.29 -3.7552 -0.9907 1113098 ChemDiv3_000288 O=C(Oc1ccccc1OC(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N03 compound treatment 186320.0 13600.0 0.53 200440.0 27800.0 1.04 1.1112 0.9498 1455237 ChemDiv3_000289 S=C1NCN(CN1)C2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N04 compound treatment 198360.0 25600.0 0.99 183280.0 10700.0 0.4 0.9861 0.9201 1652365 ChemDiv3_000290 CC(C)c1cc(CN2CCN(CC2)c3ccccc3)c(O)c(CN4CCN(CC4)c5ccccc5)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N05 compound treatment 188640.0 15900.0 0.62 346800.0 174000.0 6.54 5.0591 0.7704 3019907 ChemDiv3_000291 CN(C)C/C(=N/O)/C(=O)Nc1ccc(C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N06 compound treatment 184280.0 11500.0 0.45 181360.0 8750.0 0.33 0.5489 0.9884 1498499 ChemDiv3_000292 COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)nc(OC)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N07 compound treatment 165920.0 -6820.0 -0.26 178400.0 5790.0 0.22 -0.0334 -0.0976 1034347 ChemDiv3_000293 N#CCCn1nnc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N08 compound treatment 238200.0 65500.0 2.54 197480.0 24900.0 0.93 2.456 0.9076 3117634 ChemDiv3_000294 CC(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccc4ccccc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N09 compound treatment 169800.0 -2940.0 -0.11 271960.0 99400.0 3.73 2.556 0.6852 1051930 ChemDiv3_000295 C(c1ccccc1)n2ccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N10 compound treatment 16200.0 -157000.0 -6.07 25640.0 -147000.0 -5.52 -8.1952 -0.9988 1022496 ChemDiv3_000296 OC(=O)CCCc1ccc2ccc3cccc4ccc1c2c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N11 compound treatment 169200.0 -3540.0 -0.14 189800.0 17200.0 0.65 0.3591 0.5444 1579194 ChemDiv3_000297 CN(C)C(=O)c1ccc(Oc2ccc(cc2)C(=O)N(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N12 compound treatment 52120.0 -121000.0 -4.68 52840.0 -120000.0 -4.5 -6.4879 -0.9998 1676465 ChemDiv3_000298 Clc1ccc(cc1)C(=O)n2c(=O)oc3cc(Cl)ccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N13 compound treatment 158840.0 -13900.0 -0.54 174000.0 1390.0 0.05 -0.3444 -0.6357 1542255 ChemDiv3_000299 CCOC(=O)c1c(O)cc(C)cc1Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N14 compound treatment 192920.0 20200.0 0.78 198440.0 25800.0 0.97 1.2392 0.9944 3117635 ChemDiv3_000300 O=C(C[n+]1ccccc1)c2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N15 compound treatment 35480.0 -137000.0 -5.33 52080.0 -121000.0 -4.52 -6.9646 -0.9967 1382153 ChemDiv3_000301 O=C1N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N16 compound treatment 152040.0 -20700.0 -0.8 183160.0 10600.0 0.4 -0.2879 -0.3215 1667966 ChemDiv3_000302 O=C(Nc1ccc(cc1)c2nc3cc(NC(=O)C4CCCCC4)ccc3o2)C5CCCCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N17 compound treatment 163200.0 -9540.0 -0.37 214960.0 42400.0 1.59 0.8622 0.5283 3019932 ChemDiv3_000303 COC(=O)c1cc2cc(Br)ccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N18 compound treatment 166880.0 -5860.0 -0.23 178520.0 5910.0 0.22 -0.0039 -0.0123 1508788 ChemDiv3_000304 CC(=O)Nc1ccc2oc3ccccc3c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N19 compound treatment 181000.0 8260.0 0.32 168920.0 -3690.0 -0.14 0.1287 0.3687 3019933 ChemDiv3_000305 NC(=O)CSc1nc2ccccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N20 compound treatment 149720.0 -23000.0 -0.89 153680.0 -18900.0 -0.71 -1.1339 -0.9936 1682374 ChemDiv3_000306 COC(=O)c1cccc(n1)C(=O)Nc2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N21 compound treatment 133400.0 -39300.0 -1.53 144920.0 -27700.0 -1.04 -1.8142 -0.9824 1467868 ChemDiv3_000307 Cc1ccc(NC(=O)C2(CC3CC4CC(C3)C2)C4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N22 compound treatment 188680.0 15900.0 0.62 177800.0 5190.0 0.19 0.5751 0.8869 3019936 ChemDiv3_000308 O=C/1OC(=N\C1=C/c2ccco2)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N23 mock treatment 195280.0 22500.0 0.87 187600.0 15000.0 0.56 1.0163 0.9773 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 N24 mock treatment 184280.0 11500.0 0.45 172640.0 31.3 0.0 0.3174 0.709 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O01 compound treatment 9400.0 -163000.0 -6.34 11200.0 -161000.0 -6.06 -8.765 -0.9997 3117636 ChemDiv3_000309 NNc1nc(cc(n1)c2ccccc2O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O02 compound treatment 176200.0 3460.0 0.13 185720.0 13100.0 0.49 0.4429 0.8683 3019937 ChemDiv3_000310 CCCc1[nH]c(Br)nc1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O03 compound treatment 180000.0 7260.0 0.28 202640.0 30000.0 1.13 0.9962 0.8575 1573334 ChemDiv3_000311 COc1nsnc1N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O04 compound treatment 209200.0 36500.0 1.41 183640.0 11000.0 0.41 1.2931 0.8773 3117637 ChemDiv3_000312 CN(C)C(=O)C[n+]1cccc(/C=N/O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O05 compound treatment 20400.0 -152000.0 -5.91 31920.0 -141000.0 -5.28 -7.9133 -0.9984 1280359 ChemDiv3_000313 CCCCC1CCC(CC1)c2ccc(cc2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O06 compound treatment 160560.0 -12200.0 -0.47 196640.0 24000.0 0.9 0.3036 0.2982 3019939 ChemDiv3_000314 C[n+]1ccccc1c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O07 compound treatment 182560.0 9820.0 0.38 189560.0 17000.0 0.64 0.7193 0.9699 1372721 ChemDiv3_000315 CCCCC1CCC(CC1)C(=O)Oc2ccc(OCC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O08 compound treatment 161520.0 -11200.0 -0.44 223480.0 50900.0 1.91 1.0422 0.5322 1559693 ChemDiv3_000316 CCOC(=O)c1[nH]c2ccc(OCC)cc2c1CCCN3C(=O)c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O09 compound treatment 199400.0 26700.0 1.03 182840.0 10200.0 0.38 1.003 0.909 1672292 ChemDiv3_000317 COC(=O)c1ccc2n(CCO)c(C)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O10 compound treatment 190000.0 17300.0 0.67 192320.0 19700.0 0.74 0.9967 0.9988 3117638 ChemDiv3_000318 CC(C)(C)CC[n+]1ccc(cc1)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O11 compound treatment 197040.0 24300.0 0.94 172760.0 151.0 0.01 0.6707 0.7114 3019783 ChemDiv3_000319 CN1C(N(C)c2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O12 compound treatment 155000.0 -17700.0 -0.69 176200.0 3590.0 0.13 -0.3914 -0.558 3019784 ChemDiv3_000320 CC(C)(C)CC[n+]1ccc(/C=N/O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O13 compound treatment 206480.0 33700.0 1.31 200200.0 27600.0 1.04 1.6579 0.9933 1564111 ChemDiv3_000321 Cc1ccc(cc1)C(=O)c2ccc(Oc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O14 compound treatment 177720.0 4980.0 0.19 180640.0 8030.0 0.3 0.3498 0.9769 1011033 ChemDiv3_000322 Cc1nc(N)c(nc1C)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O15 compound treatment 15200.0 -158000.0 -6.11 48440.0 -124000.0 -4.66 -7.6176 -0.991 1628748 ChemDiv3_000323 CN(CC(=O)C1=C(C(=O)c2ccccc2C1=O)c3ccc(Br)cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O16 compound treatment 181680.0 8940.0 0.35 187320.0 14700.0 0.55 0.6357 0.9749 1540210 ChemDiv3_000324 Nc1c(N2CCOCC2)c3ccccc3oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O17 compound treatment 178120.0 5380.0 0.21 183640.0 11000.0 0.41 0.4404 0.9497 1072203 ChemDiv3_000325 CCCn1c2ccccc2c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O18 compound treatment 151600.0 -21100.0 -0.82 198120.0 25500.0 0.96 0.097 0.077 3019785 ChemDiv3_000326 COc1ccc(/C=C/2\C(C)CC=C(C(C)C)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O19 compound treatment 187080.0 14300.0 0.56 219760.0 47200.0 1.77 1.6448 0.8866 1084080 ChemDiv3_000327 CC[n+]1ccc(C)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O20 compound treatment 221160.0 48400.0 1.88 181680.0 9070.0 0.34 1.5692 0.8219 1594899 ChemDiv3_000328 COC(=O)CNC(=O)c1cc(OC)c(OC)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O21 compound treatment 129680.0 -43100.0 -1.67 172760.0 151.0 0.01 -1.1774 -0.7047 1181132 ChemDiv3_000329 O=C(NCC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O22 compound treatment 176160.0 3420.0 0.13 187440.0 14800.0 0.56 0.4874 0.8518 1124218 ChemDiv3_000330 CCc1nc(C)ccc1OCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O23 mock treatment 207360.0 34600.0 1.34 193200.0 20600.0 0.77 1.4963 0.9655 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 O24 mock treatment 192240.0 19500.0 0.76 199840.0 27200.0 1.02 1.2577 0.989 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P01 compound treatment 191040.0 18300.0 0.71 189080.0 16500.0 0.62 0.9392 0.9976 1003174 ChemDiv3_000331 CC(O)c1ccc(Oc2ccc(cc2)C(C)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P02 compound treatment 184560.0 11800.0 0.46 198520.0 25900.0 0.97 1.012 0.9412 3019787 ChemDiv3_000332 CN(C)c1ccc(/C=N/c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P03 compound treatment 198840.0 26100.0 1.01 211200.0 38600.0 1.45 1.7402 0.9847 1340347 ChemDiv3_000333 CC(C)(C)c1cc(CN2CCN(CCC#N)CC2)cc(c1O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P04 compound treatment 187560.0 14800.0 0.58 204600.0 32000.0 1.2 1.2556 0.9432 3019803 ChemDiv3_000334 COc1cccc2s/c(=N/C(=O)CC3(CC4CC5CC(C4)C3)C5)/n(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P05 compound treatment 96560.0 -76200.0 -2.96 180440.0 7830.0 0.29 -1.8822 -0.6337 1922875 ChemDiv3_000335 CCN(CC)C(=O)C1(CC2CC3C1)CC(C2)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P06 compound treatment 194200.0 21500.0 0.83 189920.0 17300.0 0.65 1.0482 0.9925 3117639 ChemDiv3_000336 O/N=C/c1cccc[n+]1CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P07 compound treatment 175880.0 3140.0 0.12 220960.0 48400.0 1.81 1.3693 0.7529 1035295 ChemDiv3_000337 CC(C)(C)N1C(=O)c2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P08 compound treatment 177600.0 4860.0 0.19 192480.0 19900.0 0.75 0.6607 0.8589 1005478 ChemDiv3_000338 Nc1ccc(Oc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P09 compound treatment 182560.0 9820.0 0.38 203840.0 31200.0 1.17 1.0983 0.8911 1734538 ChemDiv3_000339 OC(=O)CCNC(=O)c1ccco1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P10 compound treatment 89360.0 -83400.0 -3.24 62000.0 -111000.0 -4.15 -5.223 -0.9924 3117642 ChemDiv3_000340 CN(C)c1ccc(/C=C/2\CCC/C(=C\c3ccccc3)/C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P11 compound treatment 199280.0 26500.0 1.03 216200.0 43600.0 1.64 1.885 0.9751 1511725 ChemDiv3_000341 COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c3cccc(c3)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P12 compound treatment 189800.0 17100.0 0.66 198040.0 25400.0 0.95 1.143 0.984 1287341 ChemDiv3_000342 O=S(=O)(N1CCOCC1)c2cccc(c2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P13 compound treatment 169560.0 -3180.0 -0.12 174040.0 1430.0 0.05 -0.0493 -0.3661 1166133 ChemDiv3_000343 CN(C)CCOC(=O)c1ccc2n(CCN(C)C)c(C)c(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P14 compound treatment 189560.0 16800.0 0.65 217600.0 45000.0 1.69 1.6555 0.9145 1920545 ChemDiv3_000344 O=c1cc([nH]c(=S)[nH]1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P15 compound treatment 156840.0 -15900.0 -0.62 166640.0 -5970.0 -0.22 -0.5946 -0.906 3117643 ChemDiv3_000345 Oc1ccc(Br)cc1/C=N\CC2(CC3CC4CC(C3)CC2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P16 compound treatment 174400.0 1660.0 0.06 190120.0 17500.0 0.66 0.5103 0.7727 1350693 ChemDiv3_000346 Nc1ccc(CCc2nc3ccccc3[nH]2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P17 compound treatment 176840.0 4100.0 0.16 201120.0 28500.0 1.07 0.8691 0.8034 1509469 ChemDiv3_000347 CCN(CC)C(=O)c1cc(nc2ccccc12)c3cc(C(=O)N(CC)CC)c4ccccc4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P18 compound treatment 173080.0 340.0 0.01 180760.0 8150.0 0.31 0.2257 0.7369 3019852 ChemDiv3_000348 O/N=C(\Cn1cncn1)/c2ccc(Cl)cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P19 compound treatment 163360.0 -9380.0 -0.36 181160.0 8550.0 0.32 -0.0304 -0.0627 1127886 ChemDiv3_000349 C(Cc1nc2ccccc2o1)Cc3nc4ccccc4o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P20 compound treatment 140760.0 -32000.0 -1.24 190480.0 17900.0 0.67 -0.4031 -0.2858 1524725 ChemDiv3_000350 COC(=O)c1cccc(n1)C(=O)Nc2cnc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P21 compound treatment 133760.0 -39000.0 -1.51 153160.0 -19400.0 -0.73 -1.5856 -0.9442 1740437 ChemDiv3_000351 OC(CNCc1ccccc1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P22 compound treatment 173400.0 660.0 0.03 168880.0 -3730.0 -0.14 -0.0808 -0.5683 3019853 ChemDiv3_000352 Brc1ccc(cc1)S(=O)(=O)/N=C(\Oc2ccccc2)/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P23 mock treatment 180640.0 7900.0 0.31 177240.0 4630.0 0.17 0.3397 0.9639 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2001 P24 mock treatment 192280.0 19500.0 0.76 182680.0 10100.0 0.38 0.8034 0.9483 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A01 compound treatment 173480.0 -3310.0 -0.13 170240.0 -4500.0 -0.17 -0.2104 -0.9909 3117644 ChemDiv3_000353 Brc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A02 compound treatment 22880.0 -154000.0 -5.97 18680.0 -156000.0 -5.86 -8.3645 -1.0 1625003 ChemDiv3_000354 NS(=O)(=O)c1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A03 compound treatment 188720.0 11900.0 0.46 175240.0 498.0 0.02 0.3404 0.735 1914243 ChemDiv3_000355 O=C(Oc1ccc2ccccc2c1)/C=C/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A04 compound treatment 184320.0 7530.0 0.29 182960.0 8220.0 0.31 0.4246 0.9996 1922486 ChemDiv3_000356 O=C/1NC(=S)S\C1=C\Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A05 compound treatment 86920.0 -89900.0 -3.49 60520.0 -114000.0 -4.29 -5.4971 -0.9947 1148913 ChemDiv3_000357 CC(C)(C)NC(=O)c1ccc2C(=O)c3ccccc3-c4onc1c42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A06 compound treatment 170080.0 -6710.0 -0.26 160400.0 -14300.0 -0.54 -0.5648 -0.9445 1082370 ChemDiv3_000358 NCCSC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A07 compound treatment 160920.0 -15900.0 -0.62 169440.0 -5300.0 -0.2 -0.5762 -0.8903 1561720 ChemDiv3_000359 Cc1ccc2nc(cc(C(=O)Nc3ccccc3)c2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A08 compound treatment 168240.0 -8550.0 -0.33 164840.0 -9900.0 -0.37 -0.4974 -0.9984 1739494 ChemDiv3_000360 CC(=O)Nc1c(N)c2ccccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A09 compound treatment 56800.0 -120000.0 -4.66 83280.0 -91500.0 -3.43 -5.7194 -0.9888 1726014 ChemDiv3_000361 C(CN1CCN(CC1)C(c2ccccc2)c3ccccc3)Cc4c[nH]c5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A10 compound treatment 182760.0 5970.0 0.23 168560.0 -6180.0 -0.23 -4.0E-4 -0.0011 1003179 ChemDiv3_000362 COc1ccc(cc1)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A11 compound treatment 160480.0 -16300.0 -0.63 158040.0 -16700.0 -0.63 -0.8908 -1.0 1574213 ChemDiv3_000363 COc1ccc(cc1)S(=O)(=O)NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A12 compound treatment 186080.0 9290.0 0.36 161120.0 -13600.0 -0.51 -0.1067 -0.1706 3117645 ChemDiv3_000364 COc1ccc(/C=N/c2ccc(cc2)C(=O)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A13 compound treatment 180960.0 4170.0 0.16 155040.0 -19700.0 -0.74 -0.4085 -0.5397 3019887 ChemDiv3_000365 O/N=C(/c1ccccc1)\c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A14 compound treatment 193920.0 17100.0 0.66 172880.0 -1860.0 -0.07 0.4205 0.6293 1478079 ChemDiv3_000366 Fc1ccc(NC(=O)c2cc3ccccc3oc2=N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A15 compound treatment 173880.0 -2910.0 -0.11 157600.0 -17100.0 -0.64 -0.5349 -0.8188 3117646 ChemDiv3_000367 Cn1c2ccc(/N=C/c3ccccc3O)cc2c4nc5ccccc5nc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A16 compound treatment 212320.0 35500.0 1.38 175160.0 418.0 0.02 0.9858 0.7151 1190781 ChemDiv3_000368 Cc1c(N=c2c(=O)c3ccccc3c2=O)c(=O)n(c4ccccc4)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A17 compound treatment 137360.0 -39400.0 -1.53 104880.0 -69900.0 -2.62 -2.9359 -0.9671 3019890 ChemDiv3_000369 CCOC(=O)n1c(=S)oc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A18 compound treatment 173880.0 -2910.0 -0.11 189240.0 14500.0 0.54 0.3048 0.5485 1644186 ChemDiv3_000370 CCOC(=O)COc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A19 compound treatment 164400.0 -12400.0 -0.48 160640.0 -14100.0 -0.53 -0.7143 -0.9989 3117647 ChemDiv3_000371 COc1cccc(/C=N/c2cccc(NC(=O)c3ccc(F)cc3)c2)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A20 compound treatment 154200.0 -22600.0 -0.88 140520.0 -34200.0 -1.28 -1.5281 -0.9827 1428551 ChemDiv3_000372 CCCC1(CCC2(CC1)c3ccc(C#N)cc3)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A21 compound treatment 169040.0 -7750.0 -0.3 165000.0 -9740.0 -0.37 -0.4713 -0.9953 3019912 ChemDiv3_000373 CC(C(=O)c1ccccc1)[n+]2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A22 compound treatment 170960.0 -5830.0 -0.23 165880.0 -8860.0 -0.33 -0.3952 -0.9824 3117648 ChemDiv3_000374 Cc1cccc(NC(=O)CN2C(=O)/C(=N\N)/c3ccccc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A23 mock treatment 177000.0 208.0 0.01 174400.0 -343.0 -0.01 -0.0034 -0.2239 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 A24 mock treatment 176240.0 -553.0 -0.02 164600.0 -10100.0 -0.38 -0.2843 -0.7457 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B01 compound treatment 168560.0 -8230.0 -0.32 144160.0 -30600.0 -1.15 -1.0375 -0.8708 3117649 ChemDiv3_000375 CCOC(=O)c1ccc(/N=C/c2ccc3OCOc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B02 compound treatment 176960.0 168.0 0.01 192560.0 17800.0 0.67 0.4775 0.7139 1617961 ChemDiv3_000376 CC(C)OC(=O)CN1C(=O)c2ccc(cc2C1=O)C(=O)OC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B03 compound treatment 193840.0 17000.0 0.66 178280.0 3540.0 0.13 0.5616 0.8324 1656957 ChemDiv3_000377 CC1(CN2CN3C1)C(=O)C(C2)(C3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B04 compound treatment 174640.0 -2150.0 -0.08 133440.0 -41300.0 -1.55 -1.1552 -0.7441 3117650 ChemDiv3_000378 COc1ccc(/C=C/2\C(C)CCC(C)(C(C)C)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B05 compound treatment 162760.0 -14000.0 -0.54 158160.0 -16600.0 -0.62 -0.8251 -0.9978 1688345 ChemDiv3_000379 Oc1nc2SCCCn2c(=O)c1Cc3cc(Cl)cc(Cl)c3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B06 compound treatment 160360.0 -16400.0 -0.64 142440.0 -32300.0 -1.21 -1.3081 -0.955 3020471 ChemDiv3_000380 COc1ccc(cc1)c2c(C)s/c(=N\c3ccc(C)cc3)/n2CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B07 compound treatment 152560.0 -24200.0 -0.94 112720.0 -62000.0 -2.33 -2.3109 -0.9205 1735047 ChemDiv3_000381 CC(=O)Oc1ccc(cc1)N(C(=O)C)S(=O)(=O)c2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B08 compound treatment 79160.0 -97600.0 -3.79 85920.0 -88800.0 -3.33 -5.0359 -0.998 3020472 ChemDiv3_000382 COc1ccc(/N=C/c2cn(nc2c3ccccc3)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B09 compound treatment 196040.0 19200.0 0.75 177440.0 2700.0 0.1 0.5997 0.7957 3020473 ChemDiv3_000383 CN(C)c1ccc(/C=N/c2cc(Br)c3OCCOc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B10 compound treatment 138120.0 -38700.0 -1.5 95720.0 -79000.0 -2.97 -3.1582 -0.9502 3020474 ChemDiv3_000384 O=C1NC(=O)C(=Cc2ccc(o2)c3ccccc3)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B11 compound treatment 138520.0 -38300.0 -1.48 159120.0 -15600.0 -0.59 -1.4646 -0.9174 3117651 ChemDiv3_000385 C(CSc1nc2ccccc2n1CCOc3ccccc3)Oc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B12 compound treatment 175360.0 -1430.0 -0.06 259360.0 84600.0 3.18 2.2064 0.6946 3020475 ChemDiv3_000386 Clc1ccc(/C=C/2\SC(=S)N(CCC(=O)Nc3ccccc3)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B13 compound treatment 168480.0 -8310.0 -0.32 162960.0 -11800.0 -0.44 -0.5408 -0.988 3117652 ChemDiv3_000387 CN1/C(=C\2/SC(=S)N(C2=O)c3ccccc3)/Sc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B14 compound treatment 185040.0 8250.0 0.32 175400.0 658.0 0.02 0.2437 0.7594 1709090 ChemDiv3_000388 CC(C)(C)NC(=S)NC(=O)C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B15 compound treatment 154960.0 -21800.0 -0.85 180720.0 5980.0 0.22 -0.4404 -0.5025 1222580 ChemDiv3_000389 C(n1ccc2ccccc12)C3(OCCO3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B16 compound treatment 172760.0 -4030.0 -0.16 159200.0 -15500.0 -0.58 -0.5231 -0.8662 3020476 ChemDiv3_000390 Cn1c[n+](C)cc1C(O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B17 compound treatment 184840.0 8050.0 0.31 168240.0 -6500.0 -0.24 0.0482 0.1217 3117653 ChemDiv3_000391 C(=N/c1ccc2ccccc2c1)\c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B18 compound treatment 166400.0 -10400.0 -0.4 156960.0 -17800.0 -0.67 -0.7571 -0.9709 3117654 ChemDiv3_000392 CC1(C)Cc2ccccc2/C(=N/c3nc(cs3)c4ccccc4)/N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B19 compound treatment 186440.0 9650.0 0.37 166640.0 -8100.0 -0.3 0.0497 0.103 1338386 ChemDiv3_000393 CCC1(CC2CC3(O)CC(O)(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B20 compound treatment 86880.0 -89900.0 -3.49 65400.0 -109000.0 -4.1 -5.3687 -0.9967 1917487 ChemDiv3_000394 CC(/N=C/c1c(O)ccc2ccccc12)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B21 compound treatment 63280.0 -114000.0 -4.4 83680.0 -91100.0 -3.42 -5.531 -0.9921 3117655 ChemDiv3_000395 S=C/1OC(=C\C1=C/N2CCCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B22 compound treatment 156160.0 -20600.0 -0.8 144880.0 -29900.0 -1.12 -1.3586 -0.9864 3020477 ChemDiv3_000396 Cc1c(/N=C/2\SCC(=O)N2/N=C\c3ccc(Br)cc3)c(=O)n(c4ccccc4)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B23 mock treatment 167200.0 -9590.0 -0.37 171840.0 -2900.0 -0.11 -0.3402 -0.8773 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 B24 mock treatment 176840.0 47.5 0.0 178200.0 3460.0 0.13 0.0931 0.7171 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C01 compound treatment 173120.0 -3670.0 -0.14 179880.0 5140.0 0.19 0.0356 0.1484 3117656 ChemDiv3_000397 O/N=C\1/C(=O)N(CC(=O)Nc2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C02 compound treatment 125440.0 -51400.0 -1.99 128840.0 -45900.0 -1.72 -2.6271 -0.9974 1329935 ChemDiv3_000398 O=C1N(CCC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C03 compound treatment 148560.0 -28200.0 -1.1 159720.0 -15000.0 -0.56 -1.1733 -0.9523 3020478 ChemDiv3_000399 Cc1cc(=O)oc(C)c1C(=O)OCC(=O)c2ccc(Cl)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C04 compound treatment 179080.0 2290.0 0.09 158240.0 -16500.0 -0.62 -0.3752 -0.5997 3117657 ChemDiv3_000400 Cc1cc(C)c2nc(NC(=O)c3ccc(C#N)cc3)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C05 compound treatment 138720.0 -38100.0 -1.48 134160.0 -40600.0 -1.52 -2.1216 -0.9999 1721945 ChemDiv3_000401 Cc1ccc2c(=O)c(coc2c1)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C06 compound treatment 178760.0 1970.0 0.08 163720.0 -11000.0 -0.41 -0.2385 -0.567 1169311 ChemDiv3_000402 OC(=O)CSC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C07 compound treatment 156760.0 -20000.0 -0.78 154560.0 -20200.0 -0.76 -1.0852 -0.9999 3117658 ChemDiv3_000403 COc1ccc(/C=C/2\CCCC3=C2NC(=S)NC3c4ccc(OC)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C08 compound treatment 172240.0 -4550.0 -0.18 183440.0 8700.0 0.33 0.1059 0.2854 1345307 ChemDiv3_000404 Cc1cc2nc(SCCN3CCCC3)[nH]c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C09 compound treatment 188120.0 11300.0 0.44 174720.0 -22.5 0.0 0.3102 0.7057 3117659 ChemDiv3_000405 Cc1sc(/N=C/c2ccccc2O)c(C#N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C10 compound treatment 171640.0 -5150.0 -0.2 172760.0 -1980.0 -0.07 -0.194 -0.9093 1625198 ChemDiv3_000406 COc1ccc(cc1OC)c2cnn(c2N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C11 compound treatment 138160.0 -38600.0 -1.5 158600.0 -16100.0 -0.61 -1.4883 -0.9206 1460903 ChemDiv3_000407 Cc1ccc(NS(=O)(=O)c2cccc(c2)C(=O)Nc3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C12 compound treatment 169440.0 -7350.0 -0.29 173840.0 -903.0 -0.03 -0.2257 -0.7855 3020479 ChemDiv3_000408 Fc1ccccc1/C=N/c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C13 compound treatment 176080.0 -713.0 -0.03 172960.0 -1780.0 -0.07 -0.0669 -0.9236 1489098 ChemDiv3_000409 CN1C2CCC1CC(C2)OC(=O)CCN3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C14 compound treatment 163840.0 -13000.0 -0.5 166200.0 -8540.0 -0.32 -0.5821 -0.9764 3117660 ChemDiv3_000410 CC(=O)NC1C(O)C(O)C(CO)OC1OCCOc2ccc(Cl)cc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C15 compound treatment 140240.0 -36600.0 -1.42 141240.0 -33500.0 -1.26 -1.892 -0.9982 3020480 ChemDiv3_000411 Fc1ccccc1/C=C\2/SC(=O)N(CN3CCCCC3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C16 compound treatment 135880.0 -40900.0 -1.59 133120.0 -41600.0 -1.56 -2.2271 -1.0 3117661 ChemDiv3_000412 Cc1cs/c(=N\c2ccccc2)/n1CC(=O)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C17 compound treatment 165000.0 -11800.0 -0.46 173280.0 -1460.0 -0.05 -0.3624 -0.7863 1338722 ChemDiv3_000413 O=c1oc2ccccc2n1CNc3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C18 compound treatment 156920.0 -19900.0 -0.77 153560.0 -21200.0 -0.8 -1.1074 -0.9999 3117662 ChemDiv3_000414 CCOc1ccc(cc1)[n+]2c(cn3CCCc32)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C19 compound treatment 169240.0 -7550.0 -0.29 158480.0 -16300.0 -0.61 -0.6388 -0.9435 3117663 ChemDiv3_000415 CC(C)C1(C)N=C(NC1=O)c2ncccc2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C20 compound treatment 166840.0 -9950.0 -0.39 155560.0 -19200.0 -0.72 -0.7821 -0.9574 3020481 ChemDiv3_000416 CC(=C)C(=O)Nc1ccc(O)c(c1)c2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C21 compound treatment 175520.0 -1270.0 -0.05 175160.0 418.0 0.02 -0.0238 -0.4601 3117664 ChemDiv3_000417 CC(C(=O)c1ccccc1)[n+]2cccc(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C22 compound treatment 153480.0 -23300.0 -0.9 174120.0 -623.0 -0.02 -0.6561 -0.7251 3020482 ChemDiv3_000418 N/C(=N\O)/C[n+]1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C23 mock treatment 155040.0 -21800.0 -0.84 163200.0 -11500.0 -0.43 -0.9031 -0.952 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 C24 mock treatment 173040.0 -3750.0 -0.15 184960.0 10200.0 0.38 0.1682 0.4101 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D01 compound treatment 175000.0 -1790.0 -0.07 178640.0 3900.0 0.15 0.0543 0.335 3117665 ChemDiv3_000419 Brc1ccc(/C=N\C2C3CC4CC(C3)CC2C4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D02 compound treatment 176040.0 -753.0 -0.03 164160.0 -10600.0 -0.4 -0.3015 -0.757 1642252 ChemDiv3_000420 CC(C(CC(=O)O)C(=O)O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D03 compound treatment 138600.0 -38200.0 -1.48 141400.0 -33300.0 -1.25 -1.9327 -0.9965 1348263 ChemDiv3_000421 CC(C)Oc1ccc2c(C)c(Cc3ccccc3)c(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D04 compound treatment 174640.0 -2150.0 -0.08 169760.0 -4980.0 -0.19 -0.1913 -0.934 1509351 ChemDiv3_000422 COc1ccc(cc1OC)C(=O)Nc2ccc3C(=O)N(C)C(=O)c3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D05 compound treatment 138920.0 -37900.0 -1.47 115680.0 -59100.0 -2.22 -2.6065 -0.9801 3020483 ChemDiv3_000423 CCN1C(=O)C(=Cc2ccc(cc2)N(C)C)C(=O)N(CC)C1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D06 compound treatment 184880.0 8090.0 0.31 197880.0 23100.0 0.87 0.8359 0.9053 3117666 ChemDiv3_000424 CCOC(=O)C1=C(C)NC(=S)NC1c2ccc(o2)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D07 compound treatment 138680.0 -38100.0 -1.48 126200.0 -48500.0 -1.82 -2.3339 -0.9946 1529711 ChemDiv3_000425 Oc1cc2ccccc2cc1C(=O)Nc3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D08 compound treatment 13560.0 -163000.0 -6.33 11920.0 -163000.0 -6.11 -8.7996 -0.9998 3117667 ChemDiv3_000426 CN(C)c1ccc(cc1)c2cccc([o+]2)c3ccc(cc3)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D09 compound treatment 146440.0 -30400.0 -1.18 167040.0 -7700.0 -0.29 -1.0372 -0.8553 3020484 ChemDiv3_000427 Nc1nc2ccc(cc2s1)c3nc4ccccc4o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D10 compound treatment 41200.0 -136000.0 -5.26 17960.0 -157000.0 -5.88 -7.8809 -0.9984 3117668 ChemDiv3_000428 Cn1c(c(/C=C\2/C(=O)Oc3ccccc3C2=O)c4ccccc14)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D11 compound treatment 167680.0 -9110.0 -0.35 170760.0 -3980.0 -0.15 -0.3557 -0.9266 3020485 ChemDiv3_000429 CCC1SC2=NCN(CN2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D12 compound treatment 161160.0 -15600.0 -0.61 169040.0 -5700.0 -0.21 -0.5802 -0.9021 1918348 ChemDiv3_000430 COc1ccc(/C=C/2\SC(=S)N(CC(=O)Nc3ccccc3)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D13 compound treatment 172520.0 -4270.0 -0.17 186720.0 12000.0 0.45 0.2007 0.4188 3117669 ChemDiv3_000431 CCN1/C(=C\2/SC(=S)NC2=O)/Sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D14 compound treatment 139280.0 -37500.0 -1.46 158680.0 -16100.0 -0.6 -1.4555 -0.9239 1556840 ChemDiv3_000432 Cc1ccc(NC(=S)NC(=O)C2(CC3CC4C2)CC(C3)CC4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D15 compound treatment 148560.0 -28200.0 -1.1 152880.0 -21900.0 -0.82 -1.3548 -0.9899 1257795 ChemDiv3_000433 O=C1CSC(N1CCc2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D16 compound treatment 147840.0 -29000.0 -1.12 154400.0 -20300.0 -0.76 -1.3342 -0.9823 3020486 ChemDiv3_000434 C[n+]1cc(ccc1/C=N/O)C(=O)NCCC[N+]2(C)CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D17 compound treatment 164520.0 -12300.0 -0.48 79240.0 -95500.0 -3.58 -2.8712 -0.7941 1486295 ChemDiv3_000435 C1CCc2c(C1)c(nc3ccc4ccccc4c23)c5cccnc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D18 compound treatment 161400.0 -15400.0 -0.6 160280.0 -14500.0 -0.54 -0.8061 -0.9989 3117670 ChemDiv3_000436 Cc1cc2CC(C)(C)N/C(=N\c3ccccc3)/c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D19 compound treatment 190360.0 13600.0 0.53 162800.0 -11900.0 -0.45 0.0553 0.08 1377733 ChemDiv3_000437 OC(=O)C1(CC2CC3C1)CC(C2)C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D20 compound treatment 171520.0 -5270.0 -0.2 172080.0 -2660.0 -0.1 -0.2153 -0.9457 1712241 ChemDiv3_000438 CCOc1ccc(Nc2nc3cc(C)ccc3cc2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D21 compound treatment 78520.0 -98300.0 -3.81 53080.0 -122000.0 -4.57 -5.925 -0.996 3020487 ChemDiv3_000439 N/C=C/1\C=C(OC1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D22 compound treatment 159120.0 -17700.0 -0.69 153280.0 -21500.0 -0.81 -1.0545 -0.9968 3117671 ChemDiv3_000440 Cc1cccc(Nc2nc3ccccn3c(=O)c2/C=N/c4cccc(C)c4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D23 mock treatment 171280.0 -5510.0 -0.21 156760.0 -18000.0 -0.67 -0.6285 -0.8877 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 D24 mock treatment 170480.0 -6310.0 -0.24 163720.0 -11000.0 -0.41 -0.4657 -0.9687 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E01 compound treatment 189520.0 12700.0 0.49 170600.0 -4140.0 -0.16 0.2393 0.4621 3020488 ChemDiv3_000441 O=C/1NC(=S)N\C1=C/c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E02 compound treatment 33720.0 -143000.0 -5.55 19160.0 -156000.0 -5.84 -8.0543 -0.9997 1159657 ChemDiv3_000442 CC1SC(=NC1(O)C2(CC3CC4CC(C3)C2)C4)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E03 compound treatment 135440.0 -41400.0 -1.6 115360.0 -59400.0 -2.23 -2.7105 -0.987 1407431 ChemDiv3_000443 Cc1ccc(NC(=O)c2cccc(Oc3ccc(C#N)cc3)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E04 compound treatment 176320.0 -473.0 -0.02 176440.0 1700.0 0.06 0.0321 0.484 1509204 ChemDiv3_000444 COC(=O)C(C)Nc1cccc(Br)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E05 compound treatment 49080.0 -128000.0 -4.96 38080.0 -137000.0 -5.13 -7.1308 -0.9999 3117672 ChemDiv3_000445 O=C(/C=C/c1ccco1)/C=C/c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E06 compound treatment 181800.0 5010.0 0.19 174400.0 -343.0 -0.01 0.1283 0.6589 1168228 ChemDiv3_000446 CNC1(CC2CC3CC(S)(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E07 compound treatment 139040.0 -37800.0 -1.46 145640.0 -29100.0 -1.09 -1.8081 -0.9896 3117673 ChemDiv3_000447 OC(=O)CCC(=O)N1N=C/2C(CCC\C2=C/c3ccc(F)cc3)C1c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E08 compound treatment 102000.0 -74800.0 -2.9 83640.0 -91100.0 -3.42 -4.4698 -0.9967 1139169 ChemDiv3_000448 C1CCN(CC1)Sc2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E09 compound treatment 188200.0 11400.0 0.44 188600.0 13900.0 0.52 0.6807 0.9968 1916119 ChemDiv3_000449 Brc1ccc(cc1)C(=O)COC(=O)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E10 compound treatment 179320.0 2530.0 0.1 171680.0 -3060.0 -0.11 -0.0119 -0.079 3020489 ChemDiv3_000450 Oc1ccc(Br)cc1/C=N/c2cc3OCCOc3cc2Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E11 compound treatment 128840.0 -48000.0 -1.86 147640.0 -27100.0 -1.02 -2.0349 -0.9596 3117674 ChemDiv3_000451 NC(=S)NC(=O)/C=C/c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E12 compound treatment 176720.0 -72.5 0.0 188520.0 13800.0 0.52 0.3637 0.7032 3020490 ChemDiv3_000452 Fc1ccc(/N=C/c2ccccc2F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E13 compound treatment 170880.0 -5910.0 -0.23 171760.0 -2980.0 -0.11 -0.2414 -0.9456 1516214 ChemDiv3_000453 CN(Cc1ccccc1)C(=O)CN2CCCC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E14 compound treatment 178480.0 1690.0 0.07 172560.0 -2180.0 -0.08 -0.0116 -0.1108 1022614 ChemDiv3_000454 OCCNC(=O)COc1ccc(Cl)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E15 compound treatment 152880.0 -23900.0 -0.93 155800.0 -18900.0 -0.71 -1.1588 -0.9914 3117675 ChemDiv3_000455 Cc1ccc(cc1)c2cs/c(=N/C(=O)Nc3ccccc3)/[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E16 compound treatment 114240.0 -62600.0 -2.43 118480.0 -56300.0 -2.11 -3.2093 -0.9976 3020491 ChemDiv3_000456 Clc1ccc(cc1Cl)c2cnc3CCCn23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E17 compound treatment 145520.0 -31300.0 -1.21 173600.0 -1140.0 -0.04 -0.8883 -0.7316 3117676 ChemDiv3_000457 CCSc1nnc(NC(=O)/C=C/c2ccccc2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E18 compound treatment 138320.0 -38500.0 -1.49 143240.0 -31500.0 -1.18 -1.8916 -0.9933 1523604 ChemDiv3_000458 CC(C)C1CCC(C)CC1OCC(O)C[N+]2(C)CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E19 compound treatment 163040.0 -13800.0 -0.53 197600.0 22900.0 0.86 0.2293 0.227 3020492 ChemDiv3_000459 O=C(/C=C\1/Nc2ccccc2NC1=O)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E20 compound treatment 26880.0 -150000.0 -5.82 23840.0 -151000.0 -5.66 -8.1178 -0.9999 3117677 ChemDiv3_000460 c1ccc2[nH]c(nc2c1)c3nc4ccccc4s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E21 compound treatment 177200.0 408.0 0.02 168040.0 -6700.0 -0.25 -0.1667 -0.6614 3020493 ChemDiv3_000461 O=C1N(C(=O)C(=Cc2ccccc2)C(=O)N1c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E22 compound treatment 188240.0 11400.0 0.44 159760.0 -15000.0 -0.56 -0.0835 -0.1166 1013141 ChemDiv3_000462 C[n+]1cccc(c1)C(=O)NO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E23 mock treatment 157520.0 -19300.0 -0.75 196240.0 21500.0 0.81 0.0418 0.038 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 E24 mock treatment 164480.0 -12300.0 -0.48 166840.0 -7900.0 -0.3 -0.5475 -0.9737 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F01 compound treatment 184400.0 7610.0 0.3 172040.0 -2700.0 -0.1 0.137 0.4389 1512742 ChemDiv3_000463 CN(C)CCNC(=O)C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F02 compound treatment 138000.0 -38800.0 -1.51 137200.0 -37500.0 -1.41 -2.0606 -0.9995 1734477 ChemDiv3_000464 O=c1n(Cc2ccccc2)c3ccccc3n1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F03 compound treatment 62680.0 -114000.0 -4.43 55320.0 -119000.0 -4.48 -6.3001 -1.0 3117678 ChemDiv3_000465 CCN(CC)C(=S)Sc1ncnc2sc3CCCCc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F04 compound treatment 169160.0 -7630.0 -0.3 184680.0 9940.0 0.37 0.0543 0.1141 3020494 ChemDiv3_000466 COC(=O)C1=C(C)N(Cc2ccccc2)C(=O)NC1c3ccccc3F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F05 compound treatment 12560.0 -164000.0 -6.37 12720.0 -162000.0 -6.08 -8.8058 -0.9997 3020545 ChemDiv3_000467 C=CCN1C(=O)NC(=O)/C(=C/c2ccco2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F06 compound treatment 178240.0 1450.0 0.06 214880.0 40100.0 1.51 1.1049 0.733 1529101 ChemDiv3_000468 Clc1ccc(NC(NC(=O)c2ccccc2)C(=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F07 compound treatment 14920.0 -162000.0 -6.28 13760.0 -161000.0 -6.04 -8.7134 -0.9998 1408295 ChemDiv3_000469 Clc1ccc(OCC(=O)CC(=O)c2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F08 compound treatment 162640.0 -14200.0 -0.55 170920.0 -3820.0 -0.14 -0.4897 -0.8629 1428920 ChemDiv3_000470 Cc1cc(C)c(OCC(O)CNC(C)(C)C)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F09 compound treatment 142120.0 -34700.0 -1.35 129840.0 -44900.0 -1.69 -2.1429 -0.9938 1291361 ChemDiv3_000471 Nc1ccc(cc1)C(=O)OCc2nc3cc4ccccc4cc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F10 compound treatment 109400.0 -67400.0 -2.61 122320.0 -52400.0 -1.97 -3.2402 -0.9902 1234670 ChemDiv3_000472 CCOC(=O)c1oc2ccccc2c1CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F11 compound treatment 159000.0 -17800.0 -0.69 168760.0 -5980.0 -0.22 -0.6469 -0.8911 1627155 ChemDiv3_000473 CN1C(=O)C(O)N(C1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F12 compound treatment 225560.0 48800.0 1.89 199880.0 25100.0 0.94 2.0051 0.9483 3020546 ChemDiv3_000474 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F13 compound treatment 181720.0 4930.0 0.19 181040.0 6300.0 0.24 0.3023 0.9945 3117679 ChemDiv3_000475 CCN1/C(=C\2/SC(=S)N(CC=C)C2=O)/Sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F14 compound treatment 157880.0 -18900.0 -0.73 136200.0 -38500.0 -1.45 -1.5418 -0.9505 3117681 ChemDiv3_000476 Cc1ccc(cc1)C2(CC3CC4CC(C3)(C2)C(=O)NC5=NCCS5)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F15 compound treatment 170600.0 -6190.0 -0.24 189720.0 15000.0 0.56 0.2276 0.3723 1673178 ChemDiv3_000477 COc1cc(cc(OC)c1OC)C2SC(C)C(=O)N2CCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F16 compound treatment 15600.0 -161000.0 -6.25 14960.0 -160000.0 -6.0 -8.6629 -0.9998 3117682 ChemDiv3_000478 COC(=O)/C=C/S(=O)(=O)c1ccc(NC(=O)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F17 compound treatment 220640.0 43800.0 1.7 180400.0 5660.0 0.21 1.3531 0.7892 1500308 ChemDiv3_000479 Cc1ccc2c(=O)cc(oc2c1)c3ccc(F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F18 compound treatment 161080.0 -15700.0 -0.61 180320.0 5580.0 0.21 -0.2831 -0.4391 3020547 ChemDiv3_000480 CC(=C1C(=NN(C1=O)c2ccccc2)C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F19 compound treatment 206120.0 29300.0 1.14 171640.0 -3100.0 -0.12 0.7223 0.6315 1047176 ChemDiv3_000481 CCOC(=O)c1cc[nH]c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F20 compound treatment 180400.0 3610.0 0.14 168520.0 -6220.0 -0.23 -0.0662 -0.243 3117683 ChemDiv3_000482 O=C1NC(=O)C(=Cc2cn(Cc3ccccc3)c4ccccc24)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F21 compound treatment 192080.0 15300.0 0.59 185360.0 10600.0 0.4 0.7012 0.9813 3020548 ChemDiv3_000483 c1cc2cc(oc2s1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F22 compound treatment 182040.0 5250.0 0.2 180800.0 6060.0 0.23 0.3047 0.9985 1488230 ChemDiv3_000484 COc1ccc(NC(=O)c2cc3cc(OC)ccc3oc2=N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F23 mock treatment 167080.0 -9710.0 -0.38 185680.0 10900.0 0.41 0.0238 0.0427 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 F24 mock treatment 182800.0 6010.0 0.23 173600.0 -1140.0 -0.04 0.1345 0.5675 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G01 compound treatment 125040.0 -51800.0 -2.01 131000.0 -43700.0 -1.64 -2.5808 -0.995 1360606 ChemDiv3_000485 CC(C)C(=O)Oc1cc(OC(=O)C(C)C)c2ccccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G02 compound treatment 212680.0 35900.0 1.39 183920.0 9180.0 0.34 1.2282 0.8562 1922577 ChemDiv3_000486 Cc1[nH]c(=S)[nH]c1C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G03 compound treatment 160520.0 -16300.0 -0.63 163720.0 -11000.0 -0.41 -0.739 -0.979 1463550 ChemDiv3_000487 Fc1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G04 compound treatment 168960.0 -7830.0 -0.3 198160.0 23400.0 0.88 0.4066 0.4372 3020549 ChemDiv3_000488 COc1ccc(/C=C\2/SC(=S)N(C)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G05 compound treatment 84960.0 -91800.0 -3.56 82560.0 -92200.0 -3.46 -4.9659 -0.9999 3117684 ChemDiv3_000489 O=C/1/C(=C/c2ccccn2)/CC\C1=C/c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G06 compound treatment 142160.0 -34600.0 -1.34 138680.0 -36100.0 -1.35 -1.9072 -1.0 1021484 ChemDiv3_000490 O=C1CSC(N1Cc2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G07 compound treatment 97600.0 -79200.0 -3.07 105520.0 -69200.0 -2.6 -4.0098 -0.9965 1308794 ChemDiv3_000491 Nc1ncc(s1)c2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G08 compound treatment 154160.0 -22600.0 -0.88 196040.0 21300.0 0.8 -0.0557 -0.0469 1604550 ChemDiv3_000492 CCN1CCCC1CNC(=O)c2cc(NC(=O)C)c(cc2OC)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G09 compound treatment 161040.0 -15800.0 -0.61 171600.0 -3140.0 -0.12 -0.5156 -0.8283 3020550 ChemDiv3_000493 Cn/1cccc\c1=N\c2cccc[n+]2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G10 compound treatment 169280.0 -7510.0 -0.29 166520.0 -8220.0 -0.31 -0.4243 -0.9996 3020551 ChemDiv3_000494 Cc1ccc(/C=N/c2cccc(Cl)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G11 compound treatment 148640.0 -28200.0 -1.09 159680.0 -15100.0 -0.57 -1.1721 -0.953 1452502 ChemDiv3_000495 Cc1cc(Nc2ccc(Cl)cc2)n3c4ccccc4nc3c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G12 compound treatment 176920.0 128.0 0.0 197680.0 22900.0 0.86 0.6122 0.7112 1609352 ChemDiv3_000496 Nc1ccc2[nH]c(nc2c1)c3ccccc3c4nc5cc(N)ccc5[nH]4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G13 compound treatment 158280.0 -18500.0 -0.72 175680.0 938.0 0.04 -0.483 -0.6717 3117685 ChemDiv3_000497 Cc1ccc(NS(=O)(=O)c2cc(ccc2Br)C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G14 compound treatment 160160.0 -16600.0 -0.65 170880.0 -3860.0 -0.14 -0.5588 -0.8449 1253750 ChemDiv3_000498 COc1ccc(cc1)N(C2SC(=O)N(C2=O)c3ccccc3)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G15 compound treatment 145880.0 -30900.0 -1.2 168120.0 -6620.0 -0.25 -1.0239 -0.8359 3020552 ChemDiv3_000499 Cc1nc2ccc3nc(NC(=O)c4ccccc4C)sc3c2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G16 compound treatment 149040.0 -27800.0 -1.08 162160.0 -12600.0 -0.47 -1.0953 -0.9316 3117686 ChemDiv3_000500 CCOc1ccc(cc1)[n+]2c(cn3CCCCCc32)c4ccc(OC)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G17 compound treatment 128600.0 -48200.0 -1.87 129360.0 -45400.0 -1.7 -2.5266 -0.9989 1162912 ChemDiv3_000501 CCc1ccc(cc1)c2nc3ccccc3c(=O)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G18 compound treatment 157920.0 -18900.0 -0.73 150440.0 -24300.0 -0.91 -1.1627 -0.9941 1671355 ChemDiv3_000502 O=C(Oc1ccc2cc(OC(=O)c3ccccc3)ccc2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G19 compound treatment 140400.0 -36400.0 -1.41 147720.0 -27000.0 -1.01 -1.7156 -0.9868 1168078 ChemDiv3_000503 COC(=O)C1=C(C)NC(=O)NC1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G20 compound treatment 150560.0 -26200.0 -1.02 159400.0 -15300.0 -0.58 -1.1269 -0.9636 1591511 ChemDiv3_000504 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G21 compound treatment 123560.0 -53200.0 -2.07 141640.0 -33100.0 -1.24 -2.339 -0.9704 1660119 ChemDiv3_000505 CCOC(=O)c1c(NC(=O)c2ccccc2C(=O)O)sc3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G22 compound treatment 70280.0 -107000.0 -4.13 88840.0 -85900.0 -3.22 -5.202 -0.9925 1447109 ChemDiv3_000506 CC(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G23 mock treatment 144480.0 -32300.0 -1.25 154960.0 -19800.0 -0.74 -1.4115 -0.9687 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 G24 mock treatment 182120.0 5330.0 0.21 167960.0 -6780.0 -0.25 -0.0338 -0.1032 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H01 compound treatment 30520.0 -146000.0 -5.68 77120.0 -97600.0 -3.66 -6.6039 -0.9776 1421806 ChemDiv3_000507 Nc1sc(c(Cc2ccccc2)c1C(=O)O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H02 compound treatment 180000.0 3210.0 0.12 166800.0 -7940.0 -0.3 -0.1228 -0.3801 3020553 ChemDiv3_000508 Cc1ccc2n(CC=C)c(=O)n(CC=C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H03 compound treatment 101120.0 -75700.0 -2.94 74560.0 -100000.0 -3.76 -4.7349 -0.9925 3117687 ChemDiv3_000509 Clc1ccccc1/C=C/C=N/c2ccc(cc2)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H04 compound treatment 235000.0 58200.0 2.26 186680.0 11900.0 0.45 1.9138 0.8312 1282292 ChemDiv3_000510 CC(C)CNP(=O)(OC1CC(C)CCC1C(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H05 compound treatment 165040.0 -11800.0 -0.46 199720.0 25000.0 0.94 0.3404 0.3266 3020554 ChemDiv3_000511 CN1C(=O)N(C)C(=O)C(=CNC2(CC3CC4CC(C3)C2)C4)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H06 compound treatment 207920.0 31100.0 1.21 174160.0 -583.0 -0.02 0.8386 0.6942 1916294 ChemDiv3_000512 O=C(NC(Sc1ncccn1)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H07 compound treatment 159600.0 -17200.0 -0.67 166960.0 -7780.0 -0.29 -0.6782 -0.9314 1433778 ChemDiv3_000513 OC(=O)CSc1nc2ccccc2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H08 compound treatment 205040.0 28200.0 1.1 181200.0 6460.0 0.24 0.9464 0.8431 1920143 ChemDiv3_000514 Sc1n[n+]2c(cc(nc2s1)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H09 compound treatment 191240.0 14400.0 0.56 188920.0 14200.0 0.53 0.7726 0.9997 3020555 ChemDiv3_000515 Nc1cc(N)cc(c1)C(=O)OCN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H10 compound treatment 168840.0 -7950.0 -0.31 168400.0 -6340.0 -0.24 -0.3865 -0.9918 3117688 ChemDiv3_000516 O=C(NCc1ccccc1)/C(=C\c2ccccc2)/NC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H11 compound treatment 121800.0 -55000.0 -2.13 121960.0 -52800.0 -1.98 -2.9096 -0.9993 3117689 ChemDiv3_000517 CCN1/C(=C\2/N(C(=S)N(C)C2=O)c3ccccc3)/C=Cc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H12 compound treatment 188640.0 11800.0 0.46 191880.0 17100.0 0.64 0.7799 0.9864 1591023 ChemDiv3_000518 CC(=O)Nc1ccc(NS(=O)(=O)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H13 compound treatment 149120.0 -27700.0 -1.07 160440.0 -14300.0 -0.54 -1.1388 -0.9487 3020556 ChemDiv3_000519 CC/C(=C\c1sc2ccc(OC)cc2[n+]1CC)/SCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H14 compound treatment 172320.0 -4470.0 -0.17 183800.0 9060.0 0.34 0.1177 0.3083 1680898 ChemDiv3_000520 S=C(NC1CCCCC1)C2(CC3CC4CC(C3)CC2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H15 compound treatment 196080.0 19300.0 0.75 185440.0 10700.0 0.4 0.8131 0.9574 1183680 ChemDiv3_000521 Clc1ccccc1NC(=O)c2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H16 compound treatment 164440.0 -12400.0 -0.48 172040.0 -2700.0 -0.1 -0.4106 -0.8382 1868581 ChemDiv3_000522 Nc1cc(=O)[nH]c(SCC=C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H17 compound treatment 193040.0 16200.0 0.63 158680.0 -16100.0 -0.6 0.0195 0.0223 1530765 ChemDiv3_000523 CC(C)(O)C1(CC2CC3C1)CC(C2)(C3)C(C)(C)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H18 compound treatment 173840.0 -2950.0 -0.11 170280.0 -4460.0 -0.17 -0.1994 -0.9828 1142850 ChemDiv3_000524 CC1(C)CC(C)(O)P(=O)(O1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H19 compound treatment 168440.0 -8350.0 -0.32 157640.0 -17100.0 -0.64 -0.683 -0.9499 1258965 ChemDiv3_000525 COC(OC)(C(=O)c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H20 compound treatment 135240.0 -41600.0 -1.61 131440.0 -43300.0 -1.63 -2.2892 -1.0 1712075 ChemDiv3_000526 Nc1ccc(cc1)C(=O)Nc2ccc(O)c(c2)c3nc4ccccc4o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H21 compound treatment 13600.0 -163000.0 -6.33 13320.0 -161000.0 -6.06 -8.7613 -0.9998 3020557 ChemDiv3_000527 CC(C)(C)N/C=C\1/C=C(SC1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H22 compound treatment 165840.0 -11000.0 -0.42 168080.0 -6660.0 -0.25 -0.4773 -0.968 1374190 ChemDiv3_000528 COc1ccc(CC(CC(=O)O)C(=O)Nc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H23 mock treatment 175960.0 -833.0 -0.03 152000.0 -22700.0 -0.85 -0.6264 -0.7333 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 H24 mock treatment 164880.0 -11900.0 -0.46 164360.0 -10400.0 -0.39 -0.6024 -0.9964 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I01 compound treatment 176440.0 -353.0 -0.01 204640.0 29900.0 1.12 0.7838 0.6984 1677573 ChemDiv3_000529 CN1C(=O)c2ccc(NC(=O)c3cccc4ccccc34)cc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I02 compound treatment 20120.0 -157000.0 -6.08 15160.0 -160000.0 -5.99 -8.5336 -1.0 1561089 ChemDiv3_000530 C1C2CC3CC1CC(C2)(C3)c4coc(n4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I03 compound treatment 161440.0 -15400.0 -0.6 184920.0 10200.0 0.38 -0.1511 -0.2135 1284188 ChemDiv3_000531 CN(C)c1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I04 compound treatment 137680.0 -39100.0 -1.52 151080.0 -23700.0 -0.89 -1.7011 -0.9674 3020558 ChemDiv3_000532 O=C/1N(CNc2ccccc2)C(=S)S\C1=C\c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I05 compound treatment 170120.0 -6670.0 -0.26 174080.0 -663.0 -0.02 -0.2006 -0.7715 3117690 ChemDiv3_000533 O=C/1/C(=C/c2cc3ccccc3o2)/CC\C1=C/c4cc5ccccc5o4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I06 compound treatment 13600.0 -163000.0 -6.33 14440.0 -160000.0 -6.02 -8.7316 -0.9997 1740048 ChemDiv3_000534 Cc1ccc(cc1C)C2(CC3CC4CC(CN)(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I07 compound treatment 24880.0 -152000.0 -5.89 29200.0 -146000.0 -5.46 -8.0304 -0.9993 3117691 ChemDiv3_000535 CC(C)C1CCC(C)/C(=C\c2ccc(N)cc2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I08 compound treatment 176240.0 -553.0 -0.02 210800.0 36100.0 1.35 0.9418 0.6958 3020559 ChemDiv3_000536 Cc1cccc(/N=C/c2c(C)c(C#N)c3nc4ccccc4n3c2O)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I09 compound treatment 204440.0 27600.0 1.07 187080.0 12300.0 0.46 1.086 0.9294 3117692 ChemDiv3_000537 Cn1c(c2ccc3ccccc3n2)[n+](C)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I10 compound treatment 176400.0 -393.0 -0.02 188600.0 13900.0 0.52 0.357 0.6861 3020560 ChemDiv3_000538 Cc1ccc(/C=N/c2cccc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I11 compound treatment 156160.0 -20600.0 -0.8 154680.0 -20100.0 -0.75 -1.0985 -0.9995 3117694 ChemDiv3_000539 CC(C)c1c(C#N)c(N)nc(SCC(=O)c2ccc(Cl)c(Cl)c2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I12 compound treatment 135560.0 -41200.0 -1.6 134080.0 -40700.0 -1.53 -2.2104 -0.9997 1294664 ChemDiv3_000540 O=S(=O)(N1CCCc2ccccc12)c3ccc4ccccc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I13 compound treatment 173120.0 -3670.0 -0.14 207880.0 33100.0 1.24 0.7787 0.622 3020561 ChemDiv3_000541 CCOc1c(NC(=O)c2ccc(N)cc2)cc(NC(=O)c3ccc(N)cc3)cc1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I14 compound treatment 157120.0 -19700.0 -0.76 180280.0 5540.0 0.21 -0.3928 -0.4965 1029333 ChemDiv3_000542 COc1ccc(cc1)S(=O)(=O)c2ccc(OC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I15 compound treatment 152200.0 -24600.0 -0.95 149680.0 -25100.0 -0.94 -1.3399 -1.0 3117695 ChemDiv3_000543 Cc1ccc(cc1)N(CCCCN2C(=O)c3ccccc3C2=O)C(=O)c4cccc(Cl)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I16 compound treatment 165680.0 -11100.0 -0.43 196480.0 21700.0 0.82 0.272 0.2948 3020562 ChemDiv3_000544 COc1ccc(cc1)C(=O)C[n+]2cc(c3ccc(OC)cc3)n4CCCCCc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I17 compound treatment 114760.0 -62000.0 -2.41 120040.0 -54700.0 -2.05 -3.1537 -0.9969 1434553 ChemDiv3_000545 CCc1ccc(cc1)C(=O)Nc2ccc(Br)cn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I18 compound treatment 154600.0 -22200.0 -0.86 175600.0 858.0 0.03 -0.5861 -0.6802 3117696 ChemDiv3_000546 OC1=C(C(N(C1=O)c2ccccc2)c3ccccc3)C(=O)/C=C/c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I19 compound treatment 178240.0 1450.0 0.06 181360.0 6620.0 0.25 0.2153 0.8457 1267294 ChemDiv3_000547 COc1ccc(cc1)N(CN2C(=O)c3ccccc3C2=O)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I20 compound treatment 189360.0 12600.0 0.49 171000.0 -3740.0 -0.14 0.2455 0.4838 1626144 ChemDiv3_000548 CC(C)C1CCC(=C(Cc2ccc(OC(=O)c3ccccc3)cc2)C1=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I21 compound treatment 165520.0 -11300.0 -0.44 166880.0 -7860.0 -0.3 -0.5179 -0.9817 3020563 ChemDiv3_000549 Cc1sc(NC(=O)/C=C/C(=O)O)c(C#N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I22 compound treatment 162920.0 -13900.0 -0.54 169080.0 -5660.0 -0.21 -0.5309 -0.9174 1738105 ChemDiv3_000550 CNC(=O)C1OC(C)(OC1C(=O)NC)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I23 mock treatment 162440.0 -14400.0 -0.56 183840.0 9100.0 0.34 -0.1523 -0.2332 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 I24 mock treatment 165240.0 -11600.0 -0.45 170800.0 -3940.0 -0.15 -0.4216 -0.8931 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J01 compound treatment 50960.0 -126000.0 -4.88 97920.0 -76800.0 -2.88 -5.4911 -0.9684 3020564 ChemDiv3_000551 COc1ccccc1NC(=O)c2c(/N=C/c3c(O)ccc4ccccc34)cnn2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J02 compound treatment 132560.0 -44200.0 -1.72 155000.0 -19700.0 -0.74 -1.7375 -0.9295 3117697 ChemDiv3_000552 FC(F)(F)c1nc2cc(Cl)ccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J03 compound treatment 181640.0 4850.0 0.19 193400.0 18700.0 0.7 0.6281 0.8663 1921072 ChemDiv3_000553 Clc1cccc(/C=N/c2ccc(cc2)N3CCOCC3)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J04 compound treatment 202880.0 26100.0 1.01 200000.0 25300.0 0.95 1.386 0.9995 1215794 ChemDiv3_000554 Cc1cc(C)n2c(Br)c(CSc3nc4ccccc4o3)nc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J05 compound treatment 143320.0 -33500.0 -1.3 163880.0 -10900.0 -0.41 -1.2066 -0.8864 3020627 ChemDiv3_000555 CCN(CC)c1ccc(C=C2C(=O)N(C)C(=S)N(C)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J06 compound treatment 170000.0 -6790.0 -0.26 187760.0 13000.0 0.49 0.1591 0.2866 1612444 ChemDiv3_000556 O=C(NCn1ccc(=O)[nH]c1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J07 compound treatment 218080.0 41300.0 1.6 222960.0 48200.0 1.81 2.4124 0.9982 1318279 ChemDiv3_000557 S=C(N1CCOCC1)c2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J08 compound treatment 164600.0 -12200.0 -0.47 196360.0 21600.0 0.81 0.2392 0.2547 1916211 ChemDiv3_000558 CC(=O)N[N+]1=C(N)c2ccccc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J09 compound treatment 178040.0 1250.0 0.05 220320.0 45600.0 1.71 1.2438 0.7268 3020628 ChemDiv3_000559 Cc1c(/C=C/2\SC(=NC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J10 compound treatment 176320.0 -473.0 -0.02 196400.0 21700.0 0.81 0.5618 0.691 1181384 ChemDiv3_000560 CCN(CC)Cn1c(=S)oc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J11 compound treatment 159440.0 -17400.0 -0.67 190800.0 16100.0 0.6 -0.0499 -0.0553 1918939 ChemDiv3_000561 CCn1c(C)nc2cc(ccc12)S(=O)(=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J12 compound treatment 177480.0 688.0 0.03 194760.0 20000.0 0.75 0.5501 0.7318 1013703 ChemDiv3_000562 OC(=O)CNc1ccc(cc1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J13 compound treatment 171800.0 -4990.0 -0.19 186360.0 11600.0 0.44 0.1713 0.3591 3117698 ChemDiv3_000563 COc1ccc2cc(C(=O)NC(=O)C)/c(=N/c3ccccc3)/oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J14 compound treatment 165320.0 -11500.0 -0.45 169400.0 -5340.0 -0.2 -0.4565 -0.9351 1005380 ChemDiv3_000564 O=C(Oc1cccc2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J15 compound treatment 160600.0 -16200.0 -0.63 183320.0 8580.0 0.32 -0.2166 -0.3068 1320959 ChemDiv3_000565 Cc1ccccc1NC(=O)CN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J16 compound treatment 169680.0 -7110.0 -0.28 203080.0 28300.0 1.06 0.5569 0.5068 3117699 ChemDiv3_000566 Cc1cccc(/C=N/c2ccc(cc2)c3nc4cc(C)c(C)cc4o3)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J17 compound treatment 102040.0 -74800.0 -2.9 204520.0 29800.0 1.12 -1.2606 -0.4056 1212050 ChemDiv3_000567 OC1(C2CC3CC(C2)CC1C3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J18 compound treatment 155880.0 -20900.0 -0.81 173320.0 -1420.0 -0.05 -0.6115 -0.752 1521008 ChemDiv3_000568 CCN(CC)P1(=O)OC(C)(C)CC1(C)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J19 compound treatment 140280.0 -36500.0 -1.42 159880.0 -14900.0 -0.56 -1.3962 -0.917 1778430 ChemDiv3_000569 CCN1C(=O)/C(=C\2/C=Cc3ccccc3N2CC)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J20 compound treatment 164800.0 -12000.0 -0.47 179920.0 5180.0 0.19 -0.1916 -0.38 1147350 ChemDiv3_000570 Clc1cccc(NCN2C(=O)CCC2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J21 compound treatment 13520.0 -163000.0 -6.34 15520.0 -159000.0 -5.98 -8.7051 -0.9996 3020629 ChemDiv3_000571 CN(C)/C=C\1/C=C(SC1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J22 compound treatment 155440.0 -21400.0 -0.83 151000.0 -23700.0 -0.89 -1.2159 -0.9993 3117701 ChemDiv3_000572 CC(CC(=O)Nc1ccccc1I)Cc2cc(C)cc(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J23 mock treatment 198480.0 21700.0 0.84 178600.0 3860.0 0.14 0.6974 0.8168 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 J24 mock treatment 185960.0 9170.0 0.36 173600.0 -1140.0 -0.04 0.2212 0.6174 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K01 compound treatment 144240.0 -32600.0 -1.26 157480.0 -17300.0 -0.65 -1.3512 -0.9519 3020630 ChemDiv3_000573 Brc1ccc(/C=N/c2nnc(NC(=O)/C=C/c3ccccc3)s2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K02 compound treatment 13960.0 -163000.0 -6.32 16360.0 -158000.0 -5.94 -8.6708 -0.9995 1679209 ChemDiv3_000574 O=C(CSC#N)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K03 compound treatment 155560.0 -21200.0 -0.82 179640.0 4900.0 0.18 -0.4526 -0.5362 1307245 ChemDiv3_000575 CCN(CC)c1ccc(cc1)C2C3=C(CC(C)(C)CC3=O)OC4=C2C(=O)CC(C)(C)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K04 compound treatment 147120.0 -29700.0 -1.15 156760.0 -18000.0 -0.67 -1.2913 -0.9676 3020631 ChemDiv3_000576 FC(F)(F)C(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K05 compound treatment 146000.0 -30800.0 -1.19 157920.0 -16800.0 -0.63 -1.2913 -0.9556 3117702 ChemDiv3_000577 COC(=O)CNC(c1ccccc1)c2cc(Br)ccc2/N=C/c3ccccc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K06 compound treatment 174800.0 -1990.0 -0.08 184200.0 9460.0 0.35 0.1963 0.5404 3020632 ChemDiv3_000578 CC(=C)C(=O)Nc1ccc2C(=O)NC(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K07 compound treatment 150640.0 -26200.0 -1.01 158480.0 -16300.0 -0.61 -1.1491 -0.9704 3117703 ChemDiv3_000579 CC(C)C1CCC(C)/C(=C\c2ccc(cc2)N(C)C)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K08 compound treatment 173440.0 -3350.0 -0.13 190280.0 15500.0 0.58 0.3204 0.5362 3020633 ChemDiv3_000580 COc1ccc(/C=C/2\Cc3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K09 compound treatment 212360.0 35600.0 1.38 219840.0 45100.0 1.69 2.1727 0.9949 3020634 ChemDiv3_000581 C[n+]1cc(cc2ccccc12)c3ccc4ccccc4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K10 compound treatment 178520.0 1730.0 0.07 198480.0 23700.0 0.89 0.6774 0.7582 3117704 ChemDiv3_000582 CC(=O)Nc1ccc(/N=C/c2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K11 compound treatment 178280.0 1490.0 0.06 256400.0 81700.0 3.06 2.2079 0.7203 1317973 ChemDiv3_000583 CC(=O)NS(=O)(=O)c1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K12 compound treatment 179600.0 2810.0 0.11 211200.0 36500.0 1.37 1.0446 0.761 1685696 ChemDiv3_000584 COCc1cc(C)nc(N2CCOCC2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K13 compound treatment 14280.0 -163000.0 -6.31 18600.0 -156000.0 -5.86 -8.6025 -0.9993 1680270 ChemDiv3_000585 CCCCN1CCN(CC1)c2nc(c3ccccc3)c4cc(C)ccc4n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K14 compound treatment 19360.0 -157000.0 -6.11 28960.0 -146000.0 -5.47 -8.1882 -0.9985 3020635 ChemDiv3_000586 COC(=O)Oc1cc2oc(=O)sc2cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K15 compound treatment 156800.0 -20000.0 -0.78 177000.0 2260.0 0.08 -0.4886 -0.6261 3117705 ChemDiv3_000587 COc1ccc(cc1)C(=O)N(CCCCN2C(=O)c3ccccc3C2=O)c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K16 compound treatment 182160.0 5370.0 0.21 194760.0 20000.0 0.75 0.6785 0.8703 1915086 ChemDiv3_000588 OCCNC(=S)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K17 compound treatment 131080.0 -45700.0 -1.77 157920.0 -16800.0 -0.63 -1.7006 -0.9033 3020636 ChemDiv3_000589 CCc1ccc(cc1)C(=O)Nc2nccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K18 compound treatment 161360.0 -15400.0 -0.6 173840.0 -903.0 -0.03 -0.4474 -0.7459 1362496 ChemDiv3_000590 O=C(Nn1cnc2ccccc2c1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K19 compound treatment 206200.0 29400.0 1.14 212440.0 37700.0 1.41 1.8073 0.9943 3117706 ChemDiv3_000591 NC(=O)C[n+]1cccc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K20 compound treatment 174720.0 -2070.0 -0.08 188000.0 13300.0 0.5 0.295 0.5852 3117707 ChemDiv3_000592 C/C(=N\N)/c1c(c2ccccc2)c3cc(Br)ccc3[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K21 compound treatment 197680.0 20900.0 0.81 182880.0 8140.0 0.31 0.789 0.911 1318329 ChemDiv3_000593 OCC1(CC2CC3C1)CC(CO)(C2)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K22 compound treatment 162080.0 -14700.0 -0.57 215040.0 40300.0 1.51 0.6658 0.4119 1110839 ChemDiv3_000594 OC(=O)c1ccccc1C(=O)OCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K23 mock treatment 181600.0 4810.0 0.19 175200.0 458.0 0.02 0.144 0.7689 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 K24 mock treatment 175880.0 -913.0 -0.04 193040.0 18300.0 0.69 0.4606 0.6698 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L01 compound treatment 176640.0 -153.0 -0.01 192040.0 17300.0 0.65 0.4549 0.7006 1272387 ChemDiv3_000595 CC(=O)Nc1ccc(NC(=O)c2ccnn2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L02 compound treatment 182280.0 5490.0 0.21 175760.0 1020.0 0.04 0.1776 0.8208 3020637 ChemDiv3_000596 C(Sc1nnc(o1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L03 compound treatment 196040.0 19200.0 0.75 189960.0 15200.0 0.57 0.9319 0.9912 3117708 ChemDiv3_000597 COC(=O)c1ccc(/C=N/c2ccc3oc(nc3c2)c4cccc(OC)c4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L04 compound treatment 195200.0 18400.0 0.71 190720.0 16000.0 0.6 0.9291 0.9962 3020638 ChemDiv3_000598 Cc1csc2nc(CSc3ccc(Cl)cc3)c(Br)n12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L05 compound treatment 182680.0 5890.0 0.23 172240.0 -2500.0 -0.09 0.0951 0.3851 3117709 ChemDiv3_000599 CC(=O)NC(=O)c/1cc2ccccc2o\c1=N/c3ccc(cc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L06 compound treatment 143600.0 -33200.0 -1.29 153560.0 -21200.0 -0.8 -1.4728 -0.9731 3020639 ChemDiv3_000600 S=c1cc[nH]c(=S)n1c2nc(sc2c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L07 compound treatment 179440.0 2650.0 0.1 202160.0 27400.0 1.03 0.8003 0.7738 3117710 ChemDiv3_000601 CC(=O)N1CCc2cc(/N=C/c3ccc(Cl)cc3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L08 compound treatment 187080.0 10300.0 0.4 219800.0 45100.0 1.69 1.478 0.8506 3020640 ChemDiv3_000602 Cc1nc2ccc(/N=C/c3ccc(Br)cc3)cc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L09 compound treatment 198240.0 21400.0 0.83 201760.0 27000.0 1.01 1.3054 0.9952 3117711 ChemDiv3_000603 Cc1n[nH]c(C)c1Sc2ccccc2/N=C/c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L10 compound treatment 232480.0 55700.0 2.16 253000.0 78300.0 2.94 3.6047 0.9886 1663127 ChemDiv3_000604 CC(C)OC(=O)C1=C(C)NC(=S)NC1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L11 compound treatment 138440.0 -38400.0 -1.49 193800.0 19100.0 0.72 -0.5465 -0.331 1238798 ChemDiv3_000605 CC[N+]1=C(C)C(C)(C)c2cc(ccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L12 compound treatment 167200.0 -9590.0 -0.37 222200.0 47500.0 1.78 0.9963 0.5475 3117713 ChemDiv3_000606 Brc1cccc(NC(=O)c2cccc3-c4ccccc4C(=O)c32)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L13 compound treatment 21760.0 -155000.0 -6.02 35640.0 -139000.0 -5.22 -7.9451 -0.9975 1507618 ChemDiv3_000607 COc1ccc2oc(=N)c(cc2c1)c3nc4ccccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L14 compound treatment 186080.0 9290.0 0.36 206040.0 31300.0 1.17 1.0854 0.8834 3020641 ChemDiv3_000608 CNc1ncnc(S)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L15 compound treatment 178200.0 1410.0 0.05 218400.0 43700.0 1.64 1.1972 0.7303 1703537 ChemDiv3_000609 O=C(CN1C(=O)c2ccccc2C1=O)Nc3nccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L16 compound treatment 179560.0 2770.0 0.11 187640.0 12900.0 0.48 0.4182 0.8435 3117714 ChemDiv3_000610 Oc1ccc(Cl)cc1/C=N/c2ccc3oc(Cc4ccc(Cl)cc4)nc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L17 compound treatment 180120.0 3330.0 0.13 200920.0 26200.0 0.98 0.786 0.7932 1529335 ChemDiv3_000611 OC(=O)C=C1C2CC3CC(C2)CC1C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L18 compound treatment 186080.0 9290.0 0.36 213040.0 38300.0 1.44 1.2712 0.8578 3117715 ChemDiv3_000612 Clc1ccccc1/C=C\2/SC(=O)N(C2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L19 compound treatment 163680.0 -13100.0 -0.51 189920.0 15200.0 0.57 0.043 0.0564 3117716 ChemDiv3_000613 CCOc1ccc(/C=C(\NC(=O)c2ccccc2)/C(=O)NC)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L20 compound treatment 174000.0 -2790.0 -0.11 186560.0 11800.0 0.44 0.237 0.5191 3020642 ChemDiv3_000614 COc1cccc2ccc(Cl)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L21 compound treatment 12560.0 -164000.0 -6.37 14720.0 -160000.0 -6.01 -8.7527 -0.9996 3020643 ChemDiv3_000615 CN/C=C\1/C=C(SC1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L22 compound treatment 163200.0 -13600.0 -0.53 167000.0 -7740.0 -0.29 -0.5784 -0.9606 3117717 ChemDiv3_000616 N#CCC(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L23 mock treatment 188560.0 11800.0 0.46 179080.0 4340.0 0.16 0.438 0.9035 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 L24 mock treatment 175960.0 -833.0 -0.03 188480.0 13700.0 0.52 0.3417 0.6615 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M01 compound treatment 66120.0 -111000.0 -4.29 141840.0 -32900.0 -1.23 -3.9096 -0.875 1490670 ChemDiv3_000617 O=C(Oc1ccccc1)Oc2ccc3oc(=O)sc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M02 compound treatment 163640.0 -13200.0 -0.51 210400.0 35700.0 1.34 0.5855 0.4088 3117718 ChemDiv3_000618 Cc1ccc(Oc2ccc(C)c(C)c2)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M03 compound treatment 181440.0 4650.0 0.18 178960.0 4220.0 0.16 0.2394 0.9979 1380597 ChemDiv3_000619 COc1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M04 compound treatment 196280.0 19500.0 0.76 194960.0 20200.0 0.76 1.0712 1.0 3020644 ChemDiv3_000620 FC(F)(F)C(=O)N(CN1C(=O)CCC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M05 compound treatment 169080.0 -7710.0 -0.3 172560.0 -2180.0 -0.08 -0.2695 -0.8687 1629777 ChemDiv3_000621 Nc1ccc(Br)cc1C(O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M06 compound treatment 196400.0 19600.0 0.76 178160.0 3420.0 0.13 0.6286 0.8148 3117719 ChemDiv3_000622 CNc1cc(NC)c2ncnc3-c4ccccc4C(=O)c1c32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M07 compound treatment 167760.0 -9030.0 -0.35 178160.0 3420.0 0.13 -0.1571 -0.421 3020645 ChemDiv3_000623 CC(C)C1CCC(C)/C(=C/c2ccc(NC(=O)CCC(=O)O)cc2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M08 compound treatment 184400.0 7610.0 0.3 187720.0 13000.0 0.49 0.5531 0.9712 1472960 ChemDiv3_000624 COc1ccc2CN(C(=O)c2c1OC)c3nnc[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M09 compound treatment 171280.0 -5510.0 -0.21 179880.0 5140.0 0.19 -0.0149 -0.0517 3020646 ChemDiv3_000625 CC(=O)n1c2ccccc2c3cc(Br)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M10 compound treatment 183000.0 6210.0 0.24 213480.0 38700.0 1.45 1.1984 0.8132 3117720 ChemDiv3_000626 COc1ccc(/C=N/c2cccc(Cl)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M11 compound treatment 99960.0 -76800.0 -2.98 96160.0 -78600.0 -2.95 -4.1935 -1.0 1922766 ChemDiv3_000627 Oc1ccccc1/C=N/c2ccc(cc2)c3nc4ccccc4s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M12 compound treatment 179480.0 2690.0 0.1 196280.0 21500.0 0.81 0.6453 0.7918 3020648 ChemDiv3_000628 CCN1C(=C(C#N)C#N)C=Cc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M13 compound treatment 175440.0 -1350.0 -0.05 182000.0 7260.0 0.27 0.1555 0.5606 1708776 ChemDiv3_000629 C1CC[N+]2(C1)CCN(CC2)c3ncccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M14 compound treatment 177080.0 288.0 0.01 208880.0 34100.0 1.28 0.9139 0.7132 1728722 ChemDiv3_000630 COc1ccc(cc1)N2C(=O)c3ccc(Oc4ccccc4)cc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M15 compound treatment 103920.0 -72900.0 -2.83 103880.0 -70900.0 -2.66 -3.8799 -0.9995 3020649 ChemDiv3_000631 COc1cccc(/N=C\c2c[nH]c3ccccc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M16 compound treatment 136520.0 -40300.0 -1.56 148840.0 -25900.0 -0.97 -1.7923 -0.9739 3117721 ChemDiv3_000632 Brc1ccc2NC(=O)CN(C(c3ccccc3)c2c1)C(=O)/C=C/c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M17 compound treatment 186080.0 9290.0 0.36 171720.0 -3020.0 -0.11 0.1746 0.4622 1294702 ChemDiv3_000633 C1CCCN(CC1)c2nc(nc(n2)N3CCCCCC3)N4CCCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M18 compound treatment 147200.0 -29600.0 -1.15 157280.0 -17500.0 -0.66 -1.2753 -0.9646 3117722 ChemDiv3_000634 Brc1ccc(NC(=O)Nc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M19 compound treatment 99440.0 -77400.0 -3.0 109120.0 -65600.0 -2.46 -3.8638 -0.9952 1311944 ChemDiv3_000635 c1c(nc2ccccn12)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M20 compound treatment 201120.0 24300.0 0.94 187080.0 12300.0 0.46 0.9949 0.9463 1216291 ChemDiv3_000636 OCCNC(=S)NC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M21 compound treatment 54320.0 -122000.0 -4.75 124320.0 -50400.0 -1.89 -4.6983 -0.9185 1664260 ChemDiv3_000637 OC(=O)c1cc(ccc1O)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M22 compound treatment 187960.0 11200.0 0.43 183720.0 8980.0 0.34 0.5446 0.9923 3020650 ChemDiv3_000638 Fc1ccccc1C(=O)Nc2cc(ccc2Br)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M23 mock treatment 200360.0 23600.0 0.91 183040.0 8300.0 0.31 0.8668 0.8973 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 M24 mock treatment 193520.0 16700.0 0.65 185280.0 10500.0 0.4 0.7386 0.9718 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N01 compound treatment 159600.0 -17200.0 -0.67 171720.0 -3020.0 -0.11 -0.5519 -0.8156 3020651 ChemDiv3_000639 Cn1nccc1C(=O)Nc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N02 compound treatment 175160.0 -1630.0 -0.06 180120.0 5380.0 0.2 0.0979 0.4629 3117723 ChemDiv3_000640 COC(=O)CSc1nnc(o1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N03 compound treatment 130920.0 -45900.0 -1.78 160080.0 -14700.0 -0.55 -1.6477 -0.8844 3117724 ChemDiv3_000641 COc1cc(Br)cc(/C=N/c2cccc(c2)c3nc4ccccc4o3)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N04 compound treatment 169160.0 -7630.0 -0.3 186160.0 11400.0 0.43 0.0936 0.1797 1628862 ChemDiv3_000642 CCOC(=O)c1csc(NC(=O)c2ccc(cc2)S(=O)(=O)N(CC)CC)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N05 compound treatment 145360.0 -31400.0 -1.22 197840.0 23100.0 0.87 -0.2494 -0.1667 1290427 ChemDiv3_000643 CC(=O)Oc1ccccc1N(C(=O)C)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N06 compound treatment 180200.0 3410.0 0.13 203680.0 28900.0 1.09 0.8615 0.7874 1570356 ChemDiv3_000644 CC(C)(C)C(=O)Nc1c(Cl)sc2nccc(=O)n12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N07 compound treatment 176280.0 -513.0 -0.02 195560.0 20800.0 0.78 0.5384 0.6889 3020698 ChemDiv3_000645 CC(=O)N1CCc2cc(/N=C/c3ccc(O)cc3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N08 compound treatment 10840.0 -166000.0 -6.44 15080.0 -160000.0 -5.99 -8.7903 -0.9994 3020699 ChemDiv3_000646 CN(C)/C=C/c1cc(=S)c2ccccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N09 compound treatment 176800.0 7.5 0.0 184160.0 9420.0 0.35 0.2501 0.7077 1598396 ChemDiv3_000647 CSc1nnc-2c(OC(Nc3ccccc32)C4CCC(=CC4)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N10 compound treatment 12280.0 -165000.0 -6.38 15400.0 -159000.0 -5.98 -8.7423 -0.9995 3020700 ChemDiv3_000648 Oc1ccc(/C=C/2\SC(=S)N(CCc3ccccc3)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N11 compound treatment 64120.0 -113000.0 -4.37 73320.0 -101000.0 -3.81 -5.7829 -0.9976 3020701 ChemDiv3_000649 CN1/C(=C/C=C/c2oc3ccccc3[n+]2C)/Oc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N12 compound treatment 85920.0 -90900.0 -3.53 121400.0 -53300.0 -2.0 -3.9088 -0.964 3117725 ChemDiv3_000650 Clc1ccc(/C=N/C(=O)CC#N)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N13 compound treatment 49080.0 -128000.0 -4.96 126680.0 -48100.0 -1.8 -4.7794 -0.9063 1340722 ChemDiv3_000651 N=c1oc2ccc3ccccc3c2cc1C(=O)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N14 compound treatment 14520.0 -162000.0 -6.3 19720.0 -155000.0 -5.82 -8.5662 -0.9992 3117726 ChemDiv3_000652 COc1cc(/C=C\2/SC(=S)N(CC=C)C2=O)ccc1OC(=O)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N15 compound treatment 157280.0 -19500.0 -0.76 188640.0 13900.0 0.52 -0.1665 -0.1811 3020702 ChemDiv3_000653 CC1=N/C(=C/c2cccnc2)/C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N16 compound treatment 129880.0 -46900.0 -1.82 167680.0 -7060.0 -0.27 -1.4745 -0.8016 3117727 ChemDiv3_000654 CCN1/C(=C/c2ccc3ccccc3[n+]2CC)/Sc4cc(NC(=O)C)ccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N17 compound treatment 44320.0 -132000.0 -5.14 83440.0 -91300.0 -3.43 -6.0576 -0.9806 1208186 ChemDiv3_000655 OC(=O)c1cc(nc2ccc(Br)cc12)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N18 compound treatment 164440.0 -12400.0 -0.48 172640.0 -2100.0 -0.08 -0.3947 -0.8126 3020703 ChemDiv3_000656 CCN1C(=O)/C(=C\C(=C\c2ccccc2)\C)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N19 compound treatment 23120.0 -154000.0 -5.96 30520.0 -144000.0 -5.41 -8.0437 -0.9988 3020704 ChemDiv3_000657 CN1C(=O)/C(=C\Nc2ccccc2)/C=C1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N20 compound treatment 100160.0 -76600.0 -2.97 194080.0 19300.0 0.73 -1.5893 -0.5193 3117728 ChemDiv3_000658 Cc1cccc(c1)N2C(=O)/C(=C\3/C(=O)Nc4ccccc34)/SC2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N21 compound treatment 172440.0 -4350.0 -0.17 182080.0 7340.0 0.28 0.0753 0.2331 1544837 ChemDiv3_000659 Cc1cc(=O)nc(SCc2nc3ccccc3[nH]2)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N22 compound treatment 179000.0 2210.0 0.09 178040.0 3300.0 0.12 0.1481 0.9838 1021435 ChemDiv3_000660 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N23 mock treatment 180880.0 4090.0 0.16 177760.0 3020.0 0.11 0.1922 0.9864 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 N24 mock treatment 184440.0 7650.0 0.3 181360.0 6620.0 0.25 0.3854 0.9961 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O01 compound treatment 205360.0 28600.0 1.11 210360.0 35600.0 1.34 1.729 0.9957 1913320 ChemDiv3_000661 O=C(Oc1ccccc1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O02 compound treatment 124400.0 -52400.0 -2.03 139040.0 -35700.0 -1.34 -2.3849 -0.9795 3020705 ChemDiv3_000662 Cc1cc(C)c(NC(=S)NC(=O)c2ccccc2)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O03 compound treatment 177680.0 888.0 0.03 203760.0 29000.0 1.09 0.7944 0.7291 3117729 ChemDiv3_000663 CCOc1ccc(N/C=N/c2ccc(OCC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O04 compound treatment 193680.0 16900.0 0.66 183640.0 8900.0 0.33 0.6995 0.9511 1253491 ChemDiv3_000664 N#CCCN(Cn1c2ccccc2c3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O05 compound treatment 181040.0 4250.0 0.16 173160.0 -1580.0 -0.06 0.0745 0.4255 1678987 ChemDiv3_000665 Cc1ccc2nc(cc(C(=O)NCc3ccccc3)c2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O06 compound treatment 122040.0 -54800.0 -2.12 160040.0 -14700.0 -0.55 -1.8924 -0.8622 1464157 ChemDiv3_000666 Cc1cc(C)c(cc1C(=O)c2ccccc2)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O07 compound treatment 19000.0 -158000.0 -6.12 16280.0 -158000.0 -5.95 -8.5346 -0.9999 1645442 ChemDiv3_000667 CCOC(=O)c1ccc(NC(=O)CCc2c[nH]c3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O08 compound treatment 9920.0 -167000.0 -6.47 12720.0 -162000.0 -6.08 -8.8782 -0.9995 1026640 ChemDiv3_000668 Nc1ccccc1CC(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O09 compound treatment 167040.0 -9750.0 -0.38 165920.0 -8820.0 -0.33 -0.5017 -0.9978 1267081 ChemDiv3_000669 CCN(CC)S(=O)(=O)c1cc(ccc1C)C(=O)Nc2ccccc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O10 compound treatment 175160.0 -1630.0 -0.06 211240.0 36500.0 1.37 0.9238 0.6737 3117730 ChemDiv3_000670 CCOc1ccc(/C=N/c2ccc3sc(C)nc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O11 compound treatment 131840.0 -45000.0 -1.74 133200.0 -41500.0 -1.56 -2.3358 -0.9984 3020706 ChemDiv3_000671 CC(C)(C)c1cc(c2OCN(CC(=O)O)Cc2c1)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O12 compound treatment 163120.0 -13700.0 -0.53 219640.0 44900.0 1.69 0.8164 0.4621 3117731 ChemDiv3_000672 CCN(CC)c1ccc2cc(C(=O)N)/c(=N/c3ccc(F)cc3)/oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O13 compound treatment 94040.0 -82800.0 -3.21 111040.0 -63700.0 -2.39 -3.961 -0.9895 3020707 ChemDiv3_000673 Clc1ccc2nc(Cl)cc(c3ccccc3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O14 compound treatment 186240.0 9450.0 0.37 214240.0 39500.0 1.48 1.3074 0.8562 3117732 ChemDiv3_000674 Cc1cccc(C)c1OC(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O15 compound treatment 12040.0 -165000.0 -6.39 16480.0 -158000.0 -5.94 -8.7203 -0.9993 3020708 ChemDiv3_000675 C(=N/c1cccc2ccccc12)/c3c[nH]c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O16 compound treatment 184600.0 7810.0 0.3 216880.0 42100.0 1.58 1.3325 0.8275 1675948 ChemDiv3_000676 OC(=O)C(NC(=O)c1ccc(F)cc1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O17 compound treatment 170520.0 -6270.0 -0.24 168040.0 -6700.0 -0.25 -0.35 -0.9999 1019063 ChemDiv3_000677 CC(C)(C)c1ccc(O)c(N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O18 compound treatment 150960.0 -25800.0 -1.0 197600.0 22900.0 0.86 -0.1021 -0.0774 1676074 ChemDiv3_000678 OC(=O)C1CCC(CC1)c2ccc(cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O19 compound treatment 188600.0 11800.0 0.46 211440.0 36700.0 1.38 1.2979 0.8941 3020709 ChemDiv3_000679 CC(C(=O)c1ccccc1)[n+]2cccc(Br)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O20 compound treatment 130440.0 -46400.0 -1.8 144400.0 -30300.0 -1.14 -2.077 -0.9757 1276194 ChemDiv3_000680 CC1(CC2CC3C1)CC(C2)(C3)NC(=O)c4ccc(Cl)cc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O21 compound treatment 185840.0 9050.0 0.35 169960.0 -4780.0 -0.18 0.1213 0.3077 1695393 ChemDiv3_000681 O=C(N1CCOCC1)C2(CC3CC4C2)CC(C3)(C4)C(=O)N5CCOCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O22 compound treatment 186720.0 9930.0 0.39 188480.0 13700.0 0.52 0.6369 0.9897 1315761 ChemDiv3_000682 CCN(CC)S(=O)(=O)c1cccc2cc(C(=O)O)c(O)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O23 mock treatment 197440.0 20600.0 0.8 173480.0 -1260.0 -0.05 0.533 0.6641 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 O24 mock treatment 189760.0 13000.0 0.5 181240.0 6500.0 0.24 0.5282 0.9447 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P01 compound treatment 181680.0 4890.0 0.19 196360.0 21600.0 0.81 0.7078 0.8495 1316678 ChemDiv3_000683 O=C(c1ccccc1)C2(CN3CN4CN(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P02 compound treatment 180680.0 3890.0 0.15 181920.0 7180.0 0.27 0.2971 0.9624 3117733 ChemDiv3_000684 CC(C)OC(=O)CSc1nnc(o1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P03 compound treatment 179520.0 2730.0 0.11 182160.0 7420.0 0.28 0.2717 0.9122 1919584 ChemDiv3_000685 Oc1ccccc1/C=N/c2ccc3oc(nc3c2)c4cccc(I)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P04 compound treatment 181080.0 4290.0 0.17 178880.0 4140.0 0.16 0.2274 0.9994 3020710 ChemDiv3_000686 OCCNC(=O)c1cc[n+](CC(=O)c2cccs2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P05 compound treatment 140520.0 -36300.0 -1.41 172720.0 -2020.0 -0.08 -1.0488 -0.7442 1512305 ChemDiv3_000687 O=C(Oc1ccccc1N(C(=O)c2ccccc2)S(=O)(=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P06 compound treatment 101360.0 -75400.0 -2.93 112680.0 -62100.0 -2.33 -3.7166 -0.9936 3020711 ChemDiv3_000688 Cc1ccc(/N=C/c2cn(nc2c3ccccc3)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P07 compound treatment 184480.0 7690.0 0.3 175840.0 1100.0 0.04 0.24 0.7972 1010956 ChemDiv3_000689 FC(F)(F)C(=O)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P08 compound treatment 87160.0 -89600.0 -3.48 138960.0 -35800.0 -1.34 -3.4088 -0.9144 3117734 ChemDiv3_000690 CC(C)C1CCC(C)CC1OC(=O)Cn2c[n+](C)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P09 compound treatment 161080.0 -15700.0 -0.61 173480.0 -1260.0 -0.05 -0.4646 -0.7598 3020712 ChemDiv3_000691 OC(=O)CCn1c(SCCOc2ccccc2)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P10 compound treatment 170920.0 -5870.0 -0.23 208360.0 33600.0 1.26 0.7311 0.5702 3117735 ChemDiv3_000692 Cc1ccc(NC(=O)CN2C(=O)/C(=C\c3ccccc3)/SC2=S)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P11 compound treatment 97320.0 -79500.0 -3.08 124960.0 -49800.0 -1.87 -3.5016 -0.9712 3020713 ChemDiv3_000693 COc1cc2sc(C)nc2c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P12 compound treatment 148280.0 -28500.0 -1.11 216760.0 42000.0 1.58 0.3328 0.1728 3117736 ChemDiv3_000694 CC1(CCC2(CC(=O)c3ccccc3)CC1)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P13 compound treatment 141640.0 -35200.0 -1.36 150800.0 -23900.0 -0.9 -1.5998 -0.9795 3020714 ChemDiv3_000695 Nc1c(C#N)c(C(=O)c2ccc(Br)cc2)n3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P14 compound treatment 200480.0 23700.0 0.92 197600.0 22900.0 0.86 1.2565 0.9994 3117737 ChemDiv3_000696 CCNc1nc(F)cc(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P15 compound treatment 183360.0 6570.0 0.25 196800.0 22100.0 0.83 0.7656 0.8838 1476541 ChemDiv3_000697 OC(=O)c1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P16 compound treatment 138240.0 -38600.0 -1.5 153960.0 -20800.0 -0.78 -1.6093 -0.9539 1722951 ChemDiv3_000698 C1CCC2(C1)Cc3ccccc3-c4nnc(c5ccccc5)n42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P17 compound treatment 143920.0 -32900.0 -1.28 95200.0 -79500.0 -2.99 -3.0129 -0.9281 3117738 ChemDiv3_000699 CCC(O)(CC)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P18 compound treatment 135640.0 -41200.0 -1.6 148480.0 -26300.0 -0.99 -1.826 -0.9731 1912570 ChemDiv3_000700 Cc1ccc(CCS(=O)(=O)c2ccc(cc2)C(C)(C)C)c[n+]1CC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P19 compound treatment 8720.0 -168000.0 -6.52 11480.0 -163000.0 -6.13 -8.944 -0.9995 3020715 ChemDiv3_000701 CN/C=C\1/C=C(N(C)C1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P20 compound treatment 177840.0 1050.0 0.04 178680.0 3940.0 0.15 0.1332 0.8693 3117739 ChemDiv3_000702 COc1ccc(/C=C\2/SC(=S)N(CCC(=O)Nc3ccccc3)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P21 compound treatment 155040.0 -21800.0 -0.84 169680.0 -5060.0 -0.19 -0.7312 -0.8451 3020716 ChemDiv3_000703 COc1ccc(OCCSc2ncnc3[nH]cnc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P22 compound treatment 167120.0 -9670.0 -0.38 172080.0 -2660.0 -0.1 -0.336 -0.8652 1343334 ChemDiv3_000704 COC(=O)C1=C(C)NC2=C(C1c3ccncc3)C(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P23 mock treatment 186240.0 9450.0 0.37 177840.0 3100.0 0.12 0.3414 0.8878 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2002 P24 mock treatment 184160.0 7370.0 0.29 169800.0 -4940.0 -0.19 0.071 0.2082 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A01 compound treatment 189360.0 16700.0 0.65 163560.0 -2820.0 -0.11 0.3836 0.5841 1702421 ChemDiv3_001057 CCc1nccn1C(=O)CCCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A02 compound treatment 172800.0 146.0 0.01 159240.0 -7140.0 -0.27 -0.1853 -0.692 1479194 ChemDiv3_001058 Clc1ccc(cc1)C(=O)Nc2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A03 compound treatment 126280.0 -46400.0 -1.8 82000.0 -84400.0 -3.17 -3.5115 -0.9641 1673755 ChemDiv3_001059 Cc1ccc(cc1NC(=O)c2ccccc2)c3nc4ccccc4s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A04 compound treatment 183160.0 10500.0 0.41 172480.0 6110.0 0.23 0.4503 0.9629 3118598 ChemDiv3_001060 CC1=Nc2ccc(cc2C1(C)C)C(F)(F)F.[O-][N+](=O)c1cc([N+](=O)[O-])c([O-])c(c1)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A05 compound treatment 174280.0 1630.0 0.06 164560.0 -1820.0 -0.07 -0.0036 -0.0382 1545532 ChemDiv3_001061 Cc1ccccc1NC(=O)CCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A06 compound treatment 102360.0 -70300.0 -2.73 88480.0 -77900.0 -2.92 -3.9958 -0.9994 1235446 ChemDiv3_001062 COC(=O)c1c(C)oc2ccc(cc12)N(C(=O)Oc3ccccc3)S(=O)(=O)c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A07 compound treatment 151000.0 -21700.0 -0.84 126840.0 -39500.0 -1.48 -1.6433 -0.9637 3118599 ChemDiv3_001063 CC1C(Cc2ccc(C)cc2)C(=O)N(C1=O)c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A08 compound treatment 169280.0 -3370.0 -0.13 155400.0 -11000.0 -0.41 -0.3838 -0.8881 1351878 ChemDiv3_001064 CC(C)(C)c1cc(c(O)c(c1)C(C)(C)C)n2nc3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A09 compound treatment 45120.0 -128000.0 -4.95 24680.0 -142000.0 -5.32 -7.2594 -0.9994 1662979 ChemDiv3_001065 CCCc1cc2c(=O)c(c(C)oc2cc1OC(=O)C)c3ccc4OCOc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A10 compound treatment 172640.0 -13.8 0.0 152560.0 -13800.0 -0.52 -0.367 -0.7078 1457143 ChemDiv3_001066 Cc1ccc(cc1)S(=O)(=O)N2C(C3CC2C=C3)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A11 compound treatment 167080.0 -5570.0 -0.22 163040.0 -3340.0 -0.13 -0.2414 -0.9662 3020384 ChemDiv3_001067 O=C/1OC(=N\C1=C/C=C/c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A12 compound treatment 171520.0 -1130.0 -0.04 174480.0 8110.0 0.3 0.184 0.5986 3118600 ChemDiv3_001068 Clc1ccc(/C=C/2\C(=O)NC(=O)N(C2=O)c3ccc(Cl)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A13 compound treatment 249160.0 76500.0 2.97 155040.0 -11300.0 -0.43 1.7982 0.5996 3020385 ChemDiv3_001069 CC(C)n1c(nc2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A14 compound treatment 193040.0 20400.0 0.79 162640.0 -3740.0 -0.14 0.4602 0.5729 1226119 ChemDiv3_001070 Brc1ccc(NC(=O)C2(CC3CC4CC(C3)C2)C4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A15 compound treatment 152760.0 -19900.0 -0.77 138240.0 -28100.0 -1.06 -1.2925 -0.9881 3020386 ChemDiv3_001071 N#Cc1c(/N=C/c2ccccc2)sc3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A16 compound treatment 262000.0 89300.0 3.47 149680.0 -16700.0 -0.63 2.0082 0.5701 3118601 ChemDiv3_001072 CCC1=Nc2ccc(Br)cc2C(N1CC(=O)NN)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A17 compound treatment 177320.0 4670.0 0.18 122360.0 -44000.0 -1.65 -1.0401 -0.6259 1259740 ChemDiv3_001073 COc1ccc(cc1)C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A18 compound treatment 124000.0 -48700.0 -1.89 90120.0 -76300.0 -2.86 -3.3586 -0.9796 3020387 ChemDiv3_001074 CC[n+]1c(/C=C/N(C)c2ccccc2)sc3ccc(OC)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A19 compound treatment 160200.0 -12500.0 -0.48 167320.0 945.0 0.04 -0.3166 -0.6534 1267587 ChemDiv3_001075 CCOc1ccc2nc(ccc2c1)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A20 compound treatment 20600.0 -152000.0 -5.9 8960.0 -157000.0 -5.91 -8.3494 -1.0 3020388 ChemDiv3_001076 CCN1/C(=C/C2=CC(=O)CC(C)(C)C2)/Sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A21 compound treatment 175360.0 2710.0 0.11 179880.0 13500.0 0.51 0.4327 0.8358 3118602 ChemDiv3_001077 Cc1n[nH]c(=S)n(/N=C/c2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A22 compound treatment 178040.0 5390.0 0.21 179800.0 13400.0 0.5 0.5041 0.9241 1512849 ChemDiv3_001078 COc1ccccc1OC(C)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A23 mock treatment 160760.0 -11900.0 -0.46 168520.0 2150.0 0.08 -0.2694 -0.5751 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 A24 mock treatment 165360.0 -7290.0 -0.28 174840.0 8470.0 0.32 0.0245 0.0577 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B01 compound treatment 72720.0 -99900.0 -3.88 73840.0 -92500.0 -3.47 -5.1976 -0.9985 3118603 ChemDiv3_001079 Cc1cccn2c(=O)c(/C=N/c3ccc(Cl)cc3)c(NCCO)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B02 compound treatment 168960.0 -3690.0 -0.14 143720.0 -22700.0 -0.85 -0.7026 -0.8148 1487953 ChemDiv3_001080 COC(=O)c1c(NC(=O)C(C)C)sc2CCCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B03 compound treatment 144720.0 -27900.0 -1.08 122760.0 -43600.0 -1.64 -1.9239 -0.98 1608654 ChemDiv3_001081 COC(=O)C1=C(CCS1)NC(=O)c2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B04 compound treatment 184920.0 12300.0 0.48 137600.0 -28800.0 -1.08 -0.4271 -0.3619 1203988 ChemDiv3_001082 Cc1ccc(C)n1c2cccc(N)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B05 compound treatment 210720.0 38100.0 1.48 163560.0 -2820.0 -0.11 0.9697 0.6549 1593401 ChemDiv3_001083 CCCCn1c(S)nc2n(C)c(=O)[nH]c(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B06 compound treatment 162000.0 -10700.0 -0.41 150400.0 -16000.0 -0.6 -0.7163 -0.9835 3020389 ChemDiv3_001084 OC(=O)c1ccc(/C=C\2/C(=O)NC(=O)N(C2=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B07 compound treatment 14960.0 -158000.0 -6.12 9680.0 -157000.0 -5.88 -8.485 -0.9998 1483637 ChemDiv3_001085 COc1cc(cc(OC)c1OC)C(=O)N=C2C(=CC(=O)C=C2C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B08 compound treatment 136560.0 -36100.0 -1.4 133960.0 -32400.0 -1.22 -1.8505 -0.9975 1211323 ChemDiv3_001086 COc1ccc(CNc2ccc(F)cc2C)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B09 compound treatment 117080.0 -55600.0 -2.16 87920.0 -78500.0 -2.94 -3.6068 -0.9883 1504008 ChemDiv3_001087 OC(=O)c1cccc(Nc2nc(c3ccccc3)c4ccccc4n2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B10 compound treatment 134600.0 -38100.0 -1.48 125400.0 -41000.0 -1.54 -2.1315 -0.9998 1495584 ChemDiv3_001088 CC1(C)Cc2c(C#N)c(NC(=O)C(c3ccccc3)c4ccccc4)sc2CO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B11 compound treatment 167120.0 -5530.0 -0.21 133200.0 -33200.0 -1.25 -1.0323 -0.817 1679056 ChemDiv3_001089 COc1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCCc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B12 compound treatment 177200.0 4550.0 0.18 173720.0 7350.0 0.28 0.3197 0.9767 3118604 ChemDiv3_001090 CC(C)(C)/N=c\1/cccccc1NCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B13 compound treatment 181320.0 8670.0 0.34 169920.0 3550.0 0.13 0.3318 0.9177 3020431 ChemDiv3_001091 CC1=C/C(=C/c2ccco2)/C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B14 compound treatment 184040.0 11400.0 0.44 171120.0 4750.0 0.18 0.4383 0.9202 1567047 ChemDiv3_001092 COc1cc(cc(OC)c1OC)C2NCCS2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B15 compound treatment 174680.0 2030.0 0.08 181200.0 14800.0 0.56 0.449 0.7991 3118605 ChemDiv3_001093 Cn1c(=O)n(C)c2ncn(C=C)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B16 compound treatment 12440.0 -160000.0 -6.22 9560.0 -157000.0 -5.89 -8.5573 -0.9996 1521623 ChemDiv3_001094 Cc1ccccc1OCC(O)Cn2c3ccccc3c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B17 compound treatment 149880.0 -22800.0 -0.88 120760.0 -45600.0 -1.71 -1.8354 -0.9527 3020432 ChemDiv3_001095 Oc1ccccc1c2cc(cc(n2)c3ccccc3)c4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B18 compound treatment 161720.0 -10900.0 -0.42 129480.0 -36900.0 -1.38 -1.2791 -0.8832 1643074 ChemDiv3_001096 CN(C)c1ccc(cc1)C2C(N3C(=O)c4ccccc4C3=O)C(=O)N2c5ccc(C)c(Cl)c5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B19 compound treatment 10840.0 -162000.0 -6.28 9040.0 -157000.0 -5.91 -8.615 -0.9995 1726140 ChemDiv3_001097 CC1(C)Cc2c(sc3ncn4nc(COc5ccc(Cl)cc5)nc4c23)C(C)(C)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B20 compound treatment 162440.0 -10200.0 -0.4 142680.0 -23700.0 -0.89 -0.9091 -0.9337 1237367 ChemDiv3_001098 O=C(C1c2ccccc2Oc3ccccc13)N4CCc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B21 compound treatment 174840.0 2190.0 0.08 172640.0 6270.0 0.24 0.2262 0.9051 3020434 ChemDiv3_001099 CC(C)(C)OC(=O)NC(=N)n1cccn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B22 compound treatment 150560.0 -22100.0 -0.86 156200.0 -10200.0 -0.38 -0.8762 -0.9337 1449384 ChemDiv3_001100 COc1ccccc1NC(=O)c2cccc(c2)S(=O)(=O)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B23 mock treatment 168040.0 -4610.0 -0.18 171520.0 5150.0 0.19 0.01 0.0378 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 B24 mock treatment 163320.0 -9330.0 -0.36 168160.0 1790.0 0.07 -0.2087 -0.5667 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C01 compound treatment 176640.0 3990.0 0.15 158600.0 -7780.0 -0.29 -0.097 -0.2936 1056652 ChemDiv3_001101 CC(C)(C)NC(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C02 compound treatment 164560.0 -8090.0 -0.31 147080.0 -19300.0 -0.72 -0.7341 -0.9301 1434405 ChemDiv3_001102 O=C(COc1ccc2ccccc2c1)Oc3ccc(cc3)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C03 compound treatment 139080.0 -33600.0 -1.3 126640.0 -39700.0 -1.49 -1.9757 -0.9977 1247192 ChemDiv3_001103 CC(C)(C)c1ccc(cc1)C(=O)Nc2ccc(NC(=O)c3ccccc3F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C04 compound treatment 148080.0 -24600.0 -0.95 124760.0 -41600.0 -1.56 -1.7786 -0.972 3020435 ChemDiv3_001104 COc1ccc(cc1)c2cs/c(=N\c3ccccc3)/n2CCCN(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C05 compound treatment 156200.0 -16500.0 -0.64 160560.0 -5820.0 -0.22 -0.6057 -0.8978 1348473 ChemDiv3_001105 O=C(Nc1cccc2ccccc12)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C06 compound treatment 163840.0 -8810.0 -0.34 163360.0 -3020.0 -0.11 -0.3218 -0.8934 1500590 ChemDiv3_001106 O=C(Nc1cc2c(ccc3ccccc32)oc1=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C07 compound treatment 165000.0 -7650.0 -0.3 123880.0 -42500.0 -1.59 -1.3378 -0.8246 1484356 ChemDiv3_001107 CCN(CC)C(=S)SCc1cn2cccc(C)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C08 compound treatment 164200.0 -8450.0 -0.33 136600.0 -29800.0 -1.12 -1.0221 -0.8776 3020436 ChemDiv3_001108 O=C(Nc1ccc(C#N)cc1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C09 compound treatment 170720.0 -1930.0 -0.08 146760.0 -19600.0 -0.74 -0.5736 -0.7752 1425597 ChemDiv3_001109 CCOC(=O)c1ccc(o1)c2coc3cc(OC(=O)C)c(CC)cc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C10 compound treatment 162560.0 -10100.0 -0.39 167680.0 1310.0 0.05 -0.2423 -0.6139 3118606 ChemDiv3_001110 O=C(Nc1ccccc1)/C(=C/c2ccccc2)/NC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C11 compound treatment 178440.0 5790.0 0.22 144960.0 -21400.0 -0.8 -0.4096 -0.4908 3020437 ChemDiv3_001111 COc1ccccc1/C=C/C/2=N/C(=C\c3ccc4OCOc4c3)/C(=O)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C12 compound treatment 165720.0 -6930.0 -0.27 183000.0 16600.0 0.62 0.251 0.3694 3118607 ChemDiv3_001112 Cc1ccc(cc1)N2C(=O)NC(=O)/C(=C\c3ccccc3)/C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C13 compound treatment 177200.0 4550.0 0.18 175440.0 9070.0 0.34 0.3653 0.9532 1917708 ChemDiv3_001113 Sc1nc2ccccc2n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C14 compound treatment 20480.0 -152000.0 -5.9 16760.0 -150000.0 -5.62 -8.1457 -0.9997 1591681 ChemDiv3_001114 Cc1cc(C)c2C3C=CCC3C(N4CC5CC=CC5c1c42)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C15 compound treatment 144320.0 -28300.0 -1.1 135480.0 -30900.0 -1.16 -1.5973 -0.9996 3118901 ChemDiv3_001115 Cc1sc(/N=C/c2cn(Cc3ccccc3)c4ccccc24)c(C#N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C16 compound treatment 132440.0 -40200.0 -1.56 71400.0 -95000.0 -3.56 -3.6238 -0.9313 3118746 ChemDiv3_001116 CSc1ccc(/C=N/N(C)S(=O)(=O)c2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C17 compound treatment 79600.0 -93100.0 -3.61 23080.0 -143000.0 -5.38 -6.3559 -0.9812 1358774 ChemDiv3_001117 Clc1ccc(cc1)C(=O)COC(=O)C2CC=CCC2C(=O)OCC(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C18 compound treatment 165120.0 -7530.0 -0.29 118360.0 -48000.0 -1.8 -1.481 -0.8112 3118747 ChemDiv3_001118 CC[n+]1ccccc1/C=C/N(C(=O)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C19 compound treatment 153960.0 -18700.0 -0.73 91280.0 -75100.0 -2.82 -2.5058 -0.861 1915904 ChemDiv3_001119 O=C1NC(=O)/C(=C\c2ccco2)/C(=O)N1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C20 compound treatment 169920.0 -2730.0 -0.11 141320.0 -25100.0 -0.94 -0.7399 -0.7819 3118748 ChemDiv3_001120 Cc1cc(NS(=O)(=O)c2ccc(/N=C/c3ccccc3O)cc2)no1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C21 compound treatment 160920.0 -11700.0 -0.46 147600.0 -18800.0 -0.7 -0.8202 -0.9777 3020438 ChemDiv3_001121 Cc1n[nH]c(=S)n(/N=C/C=C/c2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C22 compound treatment 163680.0 -8970.0 -0.35 144120.0 -22300.0 -0.84 -0.8368 -0.9247 1314862 ChemDiv3_001122 CC(Oc1ccc2ccccc2c1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C23 mock treatment 164560.0 -8090.0 -0.31 160160.0 -6220.0 -0.23 -0.387 -0.9893 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 C24 mock treatment 181480.0 8830.0 0.34 184200.0 17800.0 0.67 0.7152 0.9516 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D01 compound treatment 49440.0 -123000.0 -4.78 28400.0 -138000.0 -5.18 -7.0422 -0.9992 3020439 ChemDiv3_001123 Clc1ccc(cc1)c2ncc3ccccn23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D02 compound treatment 167240.0 -5410.0 -0.21 157480.0 -8900.0 -0.33 -0.3846 -0.9751 1146210 ChemDiv3_001124 CN(C)CCNc1cnn(c2ccccc2)c(=O)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D03 compound treatment 159440.0 -13200.0 -0.51 143760.0 -22600.0 -0.85 -0.9627 -0.9709 1432100 ChemDiv3_001125 COC(=O)C1=C(CCS1)NC(=O)c2ccc(cc2)S(=O)(=O)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D04 compound treatment 191960.0 19300.0 0.75 152440.0 -13900.0 -0.52 0.1599 0.175 1339626 ChemDiv3_001126 OC(=O)CCC(=O)Nc1sc2CCCCc2c1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D05 compound treatment 156560.0 -16100.0 -0.62 161760.0 -4620.0 -0.17 -0.564 -0.8704 1228834 ChemDiv3_001127 CCCCc1c(O)nc(SCCN(C)C)n(c2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D06 compound treatment 189400.0 16700.0 0.65 159720.0 -6660.0 -0.25 0.2828 0.4063 3020440 ChemDiv3_001128 OC(=O)COc1c(Cl)cc(C=C2C(=O)NC(=S)NC2=O)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D07 compound treatment 174480.0 1830.0 0.07 88720.0 -77700.0 -2.91 -2.0108 -0.6897 1175621 ChemDiv3_001129 Cc1c(Cl)c(O)c(Cl)c(C)c1N(S(=O)(=O)c2ccccc2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D08 compound treatment 168240.0 -4410.0 -0.17 149240.0 -17100.0 -0.64 -0.5758 -0.8653 1419799 ChemDiv3_001130 COc1ccc(CNCc2cccc(OC)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D09 compound treatment 147640.0 -25000.0 -0.97 162240.0 -4140.0 -0.16 -0.796 -0.8099 1117976 ChemDiv3_001131 CCOC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D10 compound treatment 190440.0 17800.0 0.69 166440.0 65.0 0.0 0.4897 0.7096 1501667 ChemDiv3_001132 COC(=O)c1ccc(Oc2nc(OC)nc(n2)N(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D11 compound treatment 142440.0 -30200.0 -1.17 122440.0 -43900.0 -1.65 -1.9949 -0.986 3118749 ChemDiv3_001133 COc1ccc(cc1)C(=O)N2N3ON=C(N3c4ccccc24)c5c(C)cc(C)cc5C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D12 compound treatment 160720.0 -11900.0 -0.46 159200.0 -7180.0 -0.27 -0.5178 -0.9667 1634877 ChemDiv3_001134 Cc1nc(=O)c(c(C)n1c2ccc(cc2)C(=O)O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D13 compound treatment 163640.0 -9010.0 -0.35 172200.0 5830.0 0.22 -0.0927 -0.2248 3118750 ChemDiv3_001135 COc1ccc(OC)c(c1)c2cc(on2)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D14 compound treatment 165640.0 -7010.0 -0.27 160640.0 -5740.0 -0.22 -0.3446 -0.9933 1149659 ChemDiv3_001136 Cc1cc(nn1C(CC(=O)O)C(=O)O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D15 compound treatment 153640.0 -19000.0 -0.74 143280.0 -23100.0 -0.87 -1.1346 -0.9968 3020658 ChemDiv3_001137 Cn1c(=O)n(Cc2ccccc2)c(=O)c3n(Cc4ccccc4)c(Cl)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D16 compound treatment 165520.0 -7130.0 -0.28 143000.0 -23400.0 -0.88 -0.8161 -0.8871 1680766 ChemDiv3_001138 NS(=O)(=O)c1ccc(NC(=O)C2CC=CCC2C(=O)N3CCOCC3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D17 compound treatment 154640.0 -18000.0 -0.7 135160.0 -31200.0 -1.17 -1.3226 -0.9695 1707287 ChemDiv3_001139 COc1ccc(cc1)c2nc(=O)c3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D18 compound treatment 173600.0 946.0 0.04 137840.0 -28500.0 -1.07 -0.7313 -0.6825 3118751 ChemDiv3_001140 Cc1nc2ccccc2c(=O)n1NC(=O)/C=C/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D19 compound treatment 165520.0 -7130.0 -0.28 171560.0 5190.0 0.19 -0.0581 -0.1718 1655686 ChemDiv3_001141 C(Oc1ccccc1)c2nc3c4c5CCCCc5sc4ncn3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D20 compound treatment 161240.0 -11400.0 -0.44 107200.0 -59200.0 -2.22 -1.8836 -0.8317 1270051 ChemDiv3_001142 CCN(C(=O)C1c2ccccc2Oc3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D21 compound treatment 18240.0 -154000.0 -5.99 15120.0 -151000.0 -5.68 -8.2506 -0.9996 3020662 ChemDiv3_001143 CC(C)(C)N1Sc2ccccc2NC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D22 compound treatment 97640.0 -75000.0 -2.91 68960.0 -97400.0 -3.66 -4.6434 -0.9936 1371498 ChemDiv3_001144 Clc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)nc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D23 mock treatment 147960.0 -24700.0 -0.96 161800.0 -4580.0 -0.17 -0.7989 -0.8208 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 D24 mock treatment 165200.0 -7450.0 -0.29 159160.0 -7220.0 -0.27 -0.396 -0.9995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E01 compound treatment 172920.0 266.0 0.01 136520.0 -29900.0 -1.12 -0.785 -0.7006 3020664 ChemDiv3_001145 NN(CCC#N)C1=NS(=O)(=O)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E02 compound treatment 184200.0 11500.0 0.45 168160.0 1790.0 0.07 0.3642 0.8039 1565298 ChemDiv3_001146 Cc1ccc(OCC(=O)NC2CCS(=O)(=O)C2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E03 compound treatment 166160.0 -6490.0 -0.25 142440.0 -23900.0 -0.9 -0.8134 -0.8718 1023964 ChemDiv3_001147 O=c1cc(ss1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E04 compound treatment 170520.0 -2130.0 -0.08 175840.0 9470.0 0.36 0.1926 0.5282 1128679 ChemDiv3_001148 OC(=O)C1CCCN(C1)S(=O)(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E05 compound treatment 159240.0 -13400.0 -0.52 119680.0 -46700.0 -1.75 -1.6073 -0.8791 3020666 ChemDiv3_001149 NC(=O)c1cccc(/N=C/c2cccc(Cl)c2Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E06 compound treatment 129040.0 -43600.0 -1.69 90800.0 -75600.0 -2.84 -3.2023 -0.9695 1433984 ChemDiv3_001150 COC(=O)C1=C(C)NC2=C(C1c3ccccc3)C(=O)CC(C2)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E07 compound treatment 91760.0 -80900.0 -3.14 39640.0 -127000.0 -4.76 -5.5828 -0.9796 1622867 ChemDiv3_001151 CCN1C(=O)c2cccc3c(ccc1c23)S(=O)(=O)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E08 compound treatment 46160.0 -126000.0 -4.91 95360.0 -71000.0 -2.67 -5.3551 -0.9588 3118752 ChemDiv3_001152 CC(C)c1cc(C(C)C)c(N)c(c1)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E09 compound treatment 164200.0 -8450.0 -0.33 149560.0 -16800.0 -0.63 -0.6782 -0.9535 3020668 ChemDiv3_001153 CC(C)OC(=O)CCN1C(=O)/C(=C/c2ccccc2)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E10 compound treatment 172560.0 -93.8 0.0 186680.0 20300.0 0.76 0.5363 0.7037 1484844 ChemDiv3_001154 CC(=O)Nc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E11 compound treatment 169800.0 -2850.0 -0.11 164000.0 -2380.0 -0.09 -0.1413 -0.9942 1314682 ChemDiv3_001155 O=C(Nc1nccs1)c2cccc(c2)S(=O)(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E12 compound treatment 78200.0 -94500.0 -3.66 73880.0 -92500.0 -3.47 -5.0461 -0.9996 3020722 ChemDiv3_001156 COc1cc(/C=C\2/S/C(=N\c3cc(C)cc(C)c3)/NC2=O)cc(Br)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E13 compound treatment 176360.0 3710.0 0.14 160200.0 -6180.0 -0.23 -0.0622 -0.228 1326481 ChemDiv3_001157 Sc1nnc(CCn2c3ccccc3c4ccccc24)n1CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E14 compound treatment 167720.0 -4930.0 -0.19 172520.0 6150.0 0.23 0.0277 0.0925 3020724 ChemDiv3_001158 Cc1ccc(cc1)c2nnc(SCC=C)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E15 compound treatment 154520.0 -18100.0 -0.7 161000.0 -5380.0 -0.2 -0.6402 -0.8746 1337418 ChemDiv3_001159 O=S(=O)(N1CCCCC1)c2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E16 compound treatment 153880.0 -18800.0 -0.73 126280.0 -40100.0 -1.5 -1.5792 -0.9445 3020725 ChemDiv3_001160 CN(/N=C/c1cccc(Br)c1)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E17 compound treatment 123240.0 -49400.0 -1.92 109720.0 -56700.0 -2.13 -2.8593 -0.9987 1502789 ChemDiv3_001161 Cc1ccc(cc1)C(=O)Nc2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E18 compound treatment 13600.0 -159000.0 -6.17 11760.0 -155000.0 -5.8 -8.4671 -0.9995 1562439 ChemDiv3_001162 OCCc1c(c2ccccc2)n(Cc3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E19 compound treatment 164320.0 -8330.0 -0.32 94560.0 -71800.0 -2.7 -2.1345 -0.7863 1347662 ChemDiv3_001163 CC(NC(=O)COc1ccccc1C(C)(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E20 compound treatment 154800.0 -17900.0 -0.69 129040.0 -37300.0 -1.4 -1.4807 -0.9472 3118753 ChemDiv3_001164 OC(=O)/C=C/C(=O)Nc1sc2CCCc2c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E21 compound treatment 111120.0 -61500.0 -2.39 82680.0 -83700.0 -3.14 -3.9094 -0.9908 1411190 ChemDiv3_001165 COC(=O)C1=C(C)NC(=C(C1c2ccc(cc2)C(C)C)C(=O)OC)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E22 compound treatment 149280.0 -23400.0 -0.91 139040.0 -27300.0 -1.03 -1.3667 -0.9981 3118754 ChemDiv3_001166 COc1ccc(/C=C/C(=O)Nc2ccc(N3CCOCC3)c(Cl)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E23 mock treatment 182520.0 9870.0 0.38 173080.0 6710.0 0.25 0.4486 0.9793 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 E24 mock treatment 180200.0 7550.0 0.29 148000.0 -18400.0 -0.69 -0.2806 -0.3745 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F01 compound treatment 89400.0 -83300.0 -3.23 31240.0 -135000.0 -5.07 -5.8705 -0.9763 1523805 ChemDiv3_001167 Clc1ccc(cc1Cl)c2csc(NC(=O)C3CC3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F02 compound treatment 159360.0 -13300.0 -0.52 135800.0 -30600.0 -1.15 -1.1762 -0.9348 1457223 ChemDiv3_001168 COc1ccccc1NC(=O)CSc2nc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F03 compound treatment 172800.0 146.0 0.01 152080.0 -14300.0 -0.54 -0.3754 -0.6996 1694096 ChemDiv3_001169 Cc1nc2cc(NC(=O)c3ccc(cc3)N4C(=O)CCC4=O)ccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F04 compound treatment 155960.0 -16700.0 -0.65 91200.0 -75200.0 -2.82 -2.4531 -0.8474 1719103 ChemDiv3_001170 CCC1(CC)Cc2ccccc2-c3nc4SCCn4c(=O)c31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F05 compound treatment 185360.0 12700.0 0.49 169880.0 3510.0 0.13 0.4416 0.8655 1784397 ChemDiv3_001171 CCCCc1c(O)nc(SCCC(=O)O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F06 compound treatment 201960.0 29300.0 1.14 192040.0 25700.0 0.96 1.4852 0.9966 3118755 ChemDiv3_001172 COc1cc(C=C2C(=O)NC(=S)NC2=O)ccc1OCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F07 compound treatment 175040.0 2390.0 0.09 150680.0 -15700.0 -0.59 -0.3511 -0.5887 1922655 ChemDiv3_001173 Cc1ccc(cc1)N2C(=O)/C(=C/C=C/c3ccccc3)/SC2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F08 compound treatment 191560.0 18900.0 0.73 154640.0 -11700.0 -0.44 0.2073 0.2422 1328915 ChemDiv3_001174 COc1cccc(c1)N2C(=O)CC(SCC(=O)Nc3ccc4ccccc4c3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F09 compound treatment 179960.0 7310.0 0.28 168200.0 1830.0 0.07 0.2489 0.8534 1522826 ChemDiv3_001175 Cc1ccc2n(C)cc(C(=O)O)c(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F10 compound treatment 180600.0 7950.0 0.31 204760.0 38400.0 1.44 1.2367 0.8394 3118902 ChemDiv3_001176 O=C(COC(=O)c1cccs1)c2ccc3OCCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F11 compound treatment 177440.0 4790.0 0.19 157240.0 -9140.0 -0.34 -0.1111 -0.285 3118903 ChemDiv3_001177 Cc1cc(C)c(C2=NON3N(C(=O)c4cccs4)c5ccccc5N32)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F12 compound treatment 178400.0 5750.0 0.22 187760.0 21400.0 0.8 0.7252 0.8706 1311807 ChemDiv3_001178 Cc1noc(n1)c2ccccc2OC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F13 compound treatment 183240.0 10600.0 0.41 183040.0 16700.0 0.63 0.7327 0.9792 3020393 ChemDiv3_001179 CCOC(=O)c1cc(no1)c2cc(OC)ccc2OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F14 compound treatment 174280.0 1630.0 0.06 196360.0 30000.0 1.13 0.8404 0.7456 1637396 ChemDiv3_001180 COc1nc(C)nc(NCC=C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F15 compound treatment 15160.0 -157000.0 -6.11 14520.0 -152000.0 -5.7 -8.3511 -0.9994 3118904 ChemDiv3_001181 Cc1ccc(cc1)C2C(=C(Oc3ccccc23)c4cccs4)C=C5C(=O)NC(=O)NC5=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F16 compound treatment 166040.0 -6610.0 -0.26 164760.0 -1620.0 -0.06 -0.2243 -0.8507 1442359 ChemDiv3_001182 COc1ccc(OCC(O)Cn2nc(C)cc2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F17 compound treatment 170680.0 -1970.0 -0.08 168200.0 1830.0 0.07 -0.0057 -0.0557 3118905 ChemDiv3_001183 CN(C)c1ccc(N/C=C/2\N=C(OC2=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F18 compound treatment 196320.0 23700.0 0.92 152360.0 -14000.0 -0.53 0.2774 0.2621 1362058 ChemDiv3_001184 COc1cccc(CC(=O)Nn2c(C)nc3ccccc3c2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F19 compound treatment 169760.0 -2890.0 -0.11 180160.0 13800.0 0.52 0.2864 0.5411 3118906 ChemDiv3_001185 C1CCc2c(C1)sc3ncn4nc(nc4c23)c5cccnc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F20 compound treatment 169800.0 -2850.0 -0.11 179600.0 13200.0 0.5 0.2727 0.5362 1616159 ChemDiv3_001186 Cc1ccc(CNC(=O)C2c3ccccc3Oc4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F21 compound treatment 192200.0 19500.0 0.76 175520.0 9150.0 0.34 0.779 0.9358 1782607 ChemDiv3_001187 CCC(CC(C)(C)O)c1n[nH]c(=S)n1CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F22 compound treatment 175120.0 2470.0 0.1 152040.0 -14300.0 -0.54 -0.3128 -0.5724 3118907 ChemDiv3_001188 O=C(CSC1=NC(=O)C(C(=O)N1)c2ccccc2)NC3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F23 mock treatment 197960.0 25300.0 0.98 173400.0 7030.0 0.26 0.8807 0.8663 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 F24 mock treatment 170680.0 -1970.0 -0.08 159720.0 -6660.0 -0.25 -0.2308 -0.8833 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G01 compound treatment 186440.0 13800.0 0.53 150840.0 -15500.0 -0.58 -0.034 -0.043 3020400 ChemDiv3_001189 C=CCn1c(n[nH]c1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G02 compound treatment 136080.0 -36600.0 -1.42 110280.0 -56100.0 -2.11 -2.4921 -0.9816 1285595 ChemDiv3_001190 CN(C)S(=O)(=O)c1ccc(cc1)C(=O)Nc2nc-3c(CCc4ccccc34)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G03 compound treatment 168160.0 -4490.0 -0.17 146800.0 -19600.0 -0.73 -0.6428 -0.8513 1230309 ChemDiv3_001191 C[N+]1(CCC2CC1)C(=C)C2(O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G04 compound treatment 153200.0 -19500.0 -0.75 114760.0 -51600.0 -1.94 -1.9035 -0.9156 3118908 ChemDiv3_001192 COc1ccc2c(C)cc(Sc3nnnn3c4ccccc4)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G05 compound treatment 176160.0 3510.0 0.14 150520.0 -15900.0 -0.6 -0.3246 -0.5317 3020403 ChemDiv3_001193 Cc1ccc(/N=C\2/C(=O)Nc3ccccc23)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G06 compound treatment 150560.0 -22100.0 -0.86 131000.0 -35400.0 -1.33 -1.545 -0.9776 1391577 ChemDiv3_001194 COC(=O)C1=C(C)NC2=C(C1c3ccccc3OC(C)C)C(=O)CC(C2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G07 compound treatment 149280.0 -23400.0 -0.91 157600.0 -8780.0 -0.33 -0.8742 -0.906 1779181 ChemDiv3_001195 Cc1cc(=O)[nH]c(SC(C(=O)O)c2ccccc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G08 compound treatment 114880.0 -57800.0 -2.24 104040.0 -62300.0 -2.34 -3.2394 -0.9998 1705952 ChemDiv3_001196 O=C(C(Sc1nc2ccccc2[nH]1)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G09 compound treatment 171480.0 -1170.0 -0.05 162200.0 -4180.0 -0.16 -0.143 -0.8764 3020442 ChemDiv3_001197 COc1ccc(/C=N/N2C(=O)/C(=C/c3ccc(OC)cc3)/SC2=S)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G10 compound treatment 165120.0 -7530.0 -0.29 152960.0 -13400.0 -0.5 -0.5627 -0.9665 1503189 ChemDiv3_001198 CNC(=O)c1ccc2nc(N)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G11 compound treatment 163040.0 -9610.0 -0.37 148200.0 -18200.0 -0.68 -0.7461 -0.9597 1316072 ChemDiv3_001199 O=S(=O)(N1CCCC1)c2cccc(c2)c3nnc(o3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G12 compound treatment 16560.0 -156000.0 -6.06 15760.0 -151000.0 -5.65 -8.2797 -0.9994 3118909 ChemDiv3_001200 Cc1cc(/C=C/2\SC(=O)NC2=O)c(C)n1c3cc(C)cc(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G13 compound treatment 170560.0 -2090.0 -0.08 168200.0 1830.0 0.07 -0.009 -0.0848 3020445 ChemDiv3_001201 CC(=C)Cn1c(SCC(=O)O)nnc1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G14 compound treatment 155640.0 -17000.0 -0.66 151760.0 -14600.0 -0.55 -0.8547 -0.9958 3118910 ChemDiv3_001202 Cc1ccc(cc1)c2nnc(SC(=O)OCc3ccccc3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G15 compound treatment 167440.0 -5210.0 -0.2 174200.0 7830.0 0.29 0.0646 0.1812 3118911 ChemDiv3_001203 COc1ccc(cc1)n2cnc3cc(/N=C/c4nc5ccccc5n4C)ccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G16 compound treatment 151320.0 -21300.0 -0.83 129600.0 -36800.0 -1.38 -1.5613 -0.9701 3020449 ChemDiv3_001204 CN(/N=C/c1ccc(C)cc1)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G17 compound treatment 122280.0 -50400.0 -1.95 113400.0 -53000.0 -1.99 -2.788 -1.0 3118912 ChemDiv3_001205 CCCCC(=O)/C=C/n1c(=S)oc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G18 compound treatment 13680.0 -159000.0 -6.17 12280.0 -154000.0 -5.78 -8.4511 -0.9995 3020450 ChemDiv3_001206 CNCCc1c(c2ccccc2)n(c3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G19 compound treatment 137040.0 -35600.0 -1.38 86320.0 -80100.0 -3.0 -3.1017 -0.9379 1598116 ChemDiv3_001207 CC(C)(C)c1ccccc1OCC(=O)Nc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G20 compound treatment 156400.0 -16300.0 -0.63 157200.0 -9180.0 -0.34 -0.6894 -0.9595 1411248 ChemDiv3_001208 CC(C)(C)OC(=O)C1=C(N)OC2=C(C(=O)CC(C)(C)C2)C31C(=O)Nc4ccccc43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G21 compound treatment 153920.0 -18700.0 -0.73 169040.0 2670.0 0.1 -0.4433 -0.6041 1864191 ChemDiv3_001209 CCC(Sc1n[nH]c(=O)[nH]c1=O)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G22 compound treatment 162760.0 -9890.0 -0.38 162280.0 -4100.0 -0.15 -0.3801 -0.9193 3020455 ChemDiv3_001210 O=C/1N(Cc2ccccc2)C(=S)S\C1=C/c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G23 mock treatment 154960.0 -17700.0 -0.69 159240.0 -7140.0 -0.27 -0.6748 -0.9157 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 G24 mock treatment 161080.0 -11600.0 -0.45 162440.0 -3940.0 -0.15 -0.422 -0.8926 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H01 compound treatment 34000.0 -139000.0 -5.38 38360.0 -128000.0 -4.8 -7.2015 -0.9984 3118913 ChemDiv3_001211 O=C(/C(=C/1\Nc2ccccc2S1)/C#N)c3ccc(cc3)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H02 compound treatment 167160.0 -5490.0 -0.21 153560.0 -12800.0 -0.48 -0.4908 -0.933 3020457 ChemDiv3_001212 FC(F)(F)c1cccc(c1)N2C(=O)CC(C3CCCO3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H03 compound treatment 170840.0 -1810.0 -0.07 150360.0 -16000.0 -0.6 -0.4748 -0.7845 1133915 ChemDiv3_001213 CC1CCc2nc(NC(=O)c3ccc(Cc4ccccc4)cc3)sc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H04 compound treatment 170600.0 -2050.0 -0.08 161760.0 -4620.0 -0.17 -0.1788 -0.9379 1679724 ChemDiv3_001214 OC(=O)CCSc1nc2ccccc2n1C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H05 compound treatment 200760.0 28100.0 1.09 184160.0 17800.0 0.67 1.2431 0.9722 3118914 ChemDiv3_001215 COc1ccc(OC)c(N/C=C(\C#N)/c2nc(cs2)c3cc4ccccc4oc3=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H06 compound treatment 159840.0 -12800.0 -0.5 156600.0 -9780.0 -0.37 -0.611 -0.9888 3020524 ChemDiv3_001216 Clc1ccc(SCCc2nc3ccccc3o2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H07 compound treatment 32320.0 -140000.0 -5.44 32880.0 -133000.0 -5.01 -7.393 -0.9991 1413360 ChemDiv3_001217 Clc1ccc(SCC2=NN(C(=O)C2)c3nc4ccccc4s3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H08 compound treatment 28680.0 -144000.0 -5.59 14840.0 -152000.0 -5.69 -7.9716 -1.0 1533668 ChemDiv3_001218 Cc1ccc(SC2=NS(=O)(=O)c3ccccc23)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H09 compound treatment 177840.0 5190.0 0.2 153040.0 -13300.0 -0.5 -0.2116 -0.3923 3118915 ChemDiv3_001219 COc1ccc(OCCSc2nc3ccccc3s2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H10 compound treatment 166960.0 -5690.0 -0.22 181480.0 15100.0 0.57 0.2447 0.4021 1368307 ChemDiv3_001220 COc1ccc(cc1)C(=O)CSc2nc3cc(OC)ccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H11 compound treatment 175480.0 2830.0 0.11 163440.0 -2940.0 -0.11 -4.0E-4 -0.0023 1480108 ChemDiv3_001221 COc1cc(cc(OC)c1OC)C(=O)NCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H12 compound treatment 152800.0 -19900.0 -0.77 147080.0 -19300.0 -0.72 -1.0568 -0.9995 1571229 ChemDiv3_001222 COc1ccc(cc1)C(=O)CC(CC(=O)c2ccc(OC)cc2)C#Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H13 compound treatment 193800.0 21100.0 0.82 180800.0 14400.0 0.54 0.963 0.9796 1449253 ChemDiv3_001223 CC(=O)Oc1ccc(cc1)N(C(=O)C)S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H14 compound treatment 176440.0 3790.0 0.15 166680.0 305.0 0.01 0.112 0.7599 3020527 ChemDiv3_001224 COc1nc(nc(C)c1Br)N(CC=C)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H15 compound treatment 189240.0 16600.0 0.64 156720.0 -9660.0 -0.36 0.1988 0.2692 1303506 ChemDiv3_001225 COc1ccc(CCn2c(C)nc(=O)c(c2C)c3ccccc3)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H16 compound treatment 165320.0 -7330.0 -0.28 163760.0 -2620.0 -0.1 -0.2706 -0.899 1333831 ChemDiv3_001226 NS(=O)(=O)c1ccc(cc1)N2C(=O)C3CC=CCC3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H17 compound treatment 162360.0 -10300.0 -0.4 164480.0 -1900.0 -0.07 -0.3327 -0.8201 3020529 ChemDiv3_001227 CCc1cc2c(=O)oc(nc2s1)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H18 compound treatment 145840.0 -26800.0 -1.04 156920.0 -9460.0 -0.35 -0.9866 -0.8975 1332696 ChemDiv3_001228 CCC(C)NC(=O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H19 compound treatment 80800.0 -91900.0 -3.56 79320.0 -87100.0 -3.27 -4.8304 -0.9991 1174891 ChemDiv3_001229 OC(=O)C1CC(=C(CC1C(=O)c2ccccc2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H20 compound treatment 195080.0 22400.0 0.87 159040.0 -7340.0 -0.28 0.4206 0.4609 1219244 ChemDiv3_001230 CCCNC(=O)N(C)c1nncnc1C(=O)NC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H21 compound treatment 173160.0 506.0 0.02 178120.0 11700.0 0.44 0.3256 0.7379 1493398 ChemDiv3_001231 O=C1N(CC2OCc3ccccc3CO2)C(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H22 compound treatment 193960.0 21300.0 0.83 185320.0 18900.0 0.71 1.0873 0.9972 1293274 ChemDiv3_001232 Nc1nc(CSc2nnc3c4ccccc4[nH]c3n2)cs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H23 mock treatment 166440.0 -6210.0 -0.24 175760.0 9390.0 0.35 0.0786 0.1841 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 H24 mock treatment 169960.0 -2690.0 -0.1 155800.0 -10600.0 -0.4 -0.3546 -0.8639 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I01 compound treatment 186440.0 13800.0 0.53 156800.0 -9580.0 -0.36 0.1241 0.1926 3119049 ChemDiv3_001233 CCn1c(n[nH]c1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I02 compound treatment 175280.0 2630.0 0.1 165360.0 -1020.0 -0.04 0.0451 0.4147 3020534 ChemDiv3_001234 Cc1nc(SCC(=O)O)c2c3CCCCc3sc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I03 compound treatment 118840.0 -53800.0 -2.09 110480.0 -55900.0 -2.1 -2.9598 -1.0 1118354 ChemDiv3_001235 Cc1ccc(cc1)C(=O)Nc2ccc3OCCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I04 compound treatment 177040.0 4390.0 0.17 159440.0 -6940.0 -0.26 -0.0637 -0.2049 1277083 ChemDiv3_001236 CCOC(=O)c1[nH]cnc1C(=O)Nc2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I05 compound treatment 171560.0 -1090.0 -0.04 156160.0 -10200.0 -0.38 -0.3011 -0.7806 3119050 ChemDiv3_001237 COc1ccc(/C=N/n2cnc3n(C)c(=O)n(\N=C\c4ccc(OC)cc4)c(=O)c23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I06 compound treatment 82280.0 -90400.0 -3.51 35360.0 -131000.0 -4.92 -5.9565 -0.9863 3020597 ChemDiv3_001238 COC(=O)Sc1nnc(o1)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I07 compound treatment 169040.0 -3610.0 -0.14 150920.0 -15500.0 -0.58 -0.5093 -0.8535 3020599 ChemDiv3_001239 Cc1cc(=O)[nH]c(SCC(=O)N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I08 compound treatment 190680.0 18000.0 0.7 193760.0 27400.0 1.03 1.2213 0.9824 3119051 ChemDiv3_001240 Cc1ccc(/N=C(\NC(=S)N)/c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I09 compound treatment 163920.0 -8730.0 -0.34 151960.0 -14400.0 -0.54 -0.6222 -0.9746 3020601 ChemDiv3_001241 CN1CCN(CC1)NC(=O)CCN2C(=O)/C(=C\c3ccccc3)/SC2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I10 compound treatment 37000.0 -136000.0 -5.26 38080.0 -128000.0 -4.82 -7.1266 -0.999 3119052 ChemDiv3_001242 CN(C)c1cc[n+](cc1)C(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I11 compound treatment 184400.0 11700.0 0.46 185200.0 18800.0 0.71 0.8219 0.9775 3119053 ChemDiv3_001243 COc1ccccc1NC(=O)c/2cc3ccccc3o\c2=N/c4ccccc4F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I12 compound treatment 170360.0 -2290.0 -0.09 219600.0 53200.0 2.0 1.3496 0.6749 1781772 ChemDiv3_001244 Cc1cc(/C=C(\C#N)/c2ccccc2)c(C)n1c3cc(C)cc(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I13 compound treatment 200040.0 27400.0 1.06 184440.0 18100.0 0.68 1.2308 0.9764 1709347 ChemDiv3_001245 COc1ccc(cc1OC)c2nnc(S)n2c3ccccc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I14 compound treatment 30160.0 -142000.0 -5.53 25920.0 -140000.0 -5.27 -7.637 -0.9997 1417740 ChemDiv3_001246 OC(COc1cccc2cccnc12)Cn3c4ccccc4c5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I15 compound treatment 178520.0 5870.0 0.23 172840.0 6470.0 0.24 0.3325 0.9995 1639763 ChemDiv3_001247 CC(C)(C)c1ccc(Cn2c(=N)n(CC(=O)O)c3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I16 compound treatment 149960.0 -22700.0 -0.88 151960.0 -14400.0 -0.54 -1.0052 -0.9726 3119054 ChemDiv3_001248 COc1ccc(CC/N=C/2\SCC(=O)N2Cc3ccccc3)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I17 compound treatment 174160.0 1510.0 0.06 168000.0 1630.0 0.06 0.0845 0.9998 3020607 ChemDiv3_001249 Oc1ccccc1/C=N/N2C(=O)C3C4CC(C=C4)C3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I18 compound treatment 171680.0 -974.0 -0.04 164240.0 -2140.0 -0.08 -0.0834 -0.9411 1913826 ChemDiv3_001250 COc1ccc(cc1)n2ccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I19 compound treatment 203560.0 30900.0 1.2 192640.0 26300.0 0.99 1.545 0.9953 3119055 ChemDiv3_001251 CCN1C(=O)/C(=C/2\SC(=S)N(C2=O)c3cccc(Cl)c3)/c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I20 compound treatment 150360.0 -22300.0 -0.87 152680.0 -13700.0 -0.51 -0.9751 -0.9691 1707679 ChemDiv3_001252 Cc1ccc(Oc2ccccc2)c(NC(=O)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I21 compound treatment 160360.0 -12300.0 -0.48 185160.0 18800.0 0.71 0.1612 0.1894 1775109 ChemDiv3_001253 CC(C)n1c(=S)[nH]c2n(C)c(=O)[nH]c(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I22 compound treatment 148160.0 -24500.0 -0.95 140680.0 -25700.0 -0.96 -1.3539 -1.0 3020611 ChemDiv3_001254 Oc1ccc(CN2CCCC2)c3cccnc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I23 mock treatment 187080.0 14400.0 0.56 168520.0 2150.0 0.08 0.4527 0.8006 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 I24 mock treatment 176320.0 3670.0 0.14 171880.0 5510.0 0.21 0.2467 0.9834 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J01 compound treatment 208200.0 35500.0 1.38 153720.0 -12700.0 -0.47 0.6394 0.4383 3119056 ChemDiv3_001255 CN1/C(=C(\C#N)/C(=O)c2ccc(F)cc2)/Nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J02 compound treatment 325040.0 152000.0 5.91 152320.0 -14100.0 -0.53 3.8078 0.6415 3020669 ChemDiv3_001256 COc1ccc(Br)cc1/C=C/C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J03 compound treatment 183240.0 10600.0 0.41 165480.0 -895.0 -0.03 0.2667 0.6471 3119057 ChemDiv3_001257 CC1=C(C(c2ccccc2)n3c(=O)/c(=C/c4cccs4)/sc3=N1)C(=O)Nc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J04 compound treatment 188280.0 15600.0 0.61 177280.0 10900.0 0.41 0.7181 0.9817 3020672 ChemDiv3_001258 Fc1ccccc1OCCSc2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J05 compound treatment 215840.0 43200.0 1.68 176240.0 9870.0 0.37 1.4467 0.843 3119058 ChemDiv3_001259 FC(F)(F)c1cccc(N/C=C(/C#N)\c2nc(cs2)c3ccc4OCOc4c3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J06 compound treatment 148840.0 -23800.0 -0.92 143120.0 -23300.0 -0.87 -1.2705 -0.9996 3020674 ChemDiv3_001260 O=C/1N\C(=N/S(=O)(=O)c2ccccc2)\S\C1=C\c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J07 compound treatment 202520.0 29900.0 1.16 164080.0 -2300.0 -0.09 0.7585 0.6527 3119059 ChemDiv3_001261 CC1(C)CC(=O)C(=CNC2CCCC2)C(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J08 compound treatment 172920.0 266.0 0.01 146240.0 -20100.0 -0.76 -0.5271 -0.6974 1223136 ChemDiv3_001262 OC(=O)CCC(=O)Nc1cccc(c1)c2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J09 compound treatment 191520.0 18900.0 0.73 166520.0 145.0 0.01 0.5215 0.7123 1160808 ChemDiv3_001263 CC(=O)Oc1ccccc1C(=O)N2CCCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J10 compound treatment 177000.0 4350.0 0.17 166560.0 185.0 0.01 0.1242 0.7356 1127019 ChemDiv3_001264 N=c1n(CC(=O)c2ccco2)c3ccccc3n1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J11 compound treatment 188560.0 15900.0 0.62 180720.0 14300.0 0.54 0.8171 0.9977 3020678 ChemDiv3_001265 O=C(CSc1nc2ccccc2s1)OCN3C(=O)c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J12 compound treatment 185720.0 13100.0 0.51 187480.0 21100.0 0.79 0.9186 0.9767 3119060 ChemDiv3_001266 C1C(=CC(=NN=C1c2cccs2)c3cccs3)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J13 compound treatment 195200.0 22500.0 0.87 181080.0 14700.0 0.55 1.0088 0.9753 1124209 ChemDiv3_001267 O=C(CCN1C(=O)c2ccccc2C1=O)Oc3ccc4c5CCCc5c(=O)oc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J14 compound treatment 183000.0 10300.0 0.4 184960.0 18600.0 0.7 0.7771 0.9656 3020681 ChemDiv3_001268 CCNc1nc(NCC)nc(OCCOC(=O)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J15 compound treatment 153160.0 -19500.0 -0.76 148360.0 -18000.0 -0.68 -1.0129 -0.9984 1222243 ChemDiv3_001269 COc1ccc(cc1OC)C2=CC(c3ccccc3)c4ccccc4O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J16 compound treatment 163360.0 -9290.0 -0.36 148240.0 -18100.0 -0.68 -0.7363 -0.9559 1443019 ChemDiv3_001270 O=C(Nc1ccc(cc1)N2CCCCC2)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J17 compound treatment 171080.0 -1570.0 -0.06 178600.0 12200.0 0.46 0.2813 0.6076 1518842 ChemDiv3_001271 CCOC(=O)c1cc2c3c4CCCCc4oc3cc(I)c2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J18 compound treatment 168120.0 -4530.0 -0.18 172280.0 5910.0 0.22 0.0323 0.1142 3020684 ChemDiv3_001272 FC(F)(F)c1ccccc1NC(=O)C2c3ccccc3Oc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J19 compound treatment 187760.0 15100.0 0.59 180280.0 13900.0 0.52 0.7835 0.9983 3119061 ChemDiv3_001273 Fc1ccc(/N=C/2\SC(CC(=O)N2CCc3ccccc3)C(=O)NCCc4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J20 compound treatment 135920.0 -36700.0 -1.43 152000.0 -14400.0 -0.54 -1.3893 -0.9116 1484388 ChemDiv3_001274 Cc1cccc(NC(=O)c2ccc(C)c(c2)S(=O)(=O)N3CCCC3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J21 compound treatment 200680.0 28000.0 1.09 190080.0 23700.0 0.89 1.398 0.995 3020364 ChemDiv3_001275 CN(C)c1ccc(/C=C(\C#N)/C(=C(C#N)C#N)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J22 compound treatment 170720.0 -1930.0 -0.08 173480.0 7110.0 0.27 0.1355 0.4892 1381241 ChemDiv3_001276 Nc1ccccc1Nc2c(N)c(=O)oc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J23 mock treatment 171600.0 -1050.0 -0.04 179400.0 13000.0 0.49 0.3168 0.6457 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 J24 mock treatment 174960.0 2310.0 0.09 176000.0 9630.0 0.36 0.3187 0.8564 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K01 compound treatment 12520.0 -160000.0 -6.21 10160.0 -156000.0 -5.86 -8.5392 -0.9996 3020366 ChemDiv3_001277 Oc1ccccc1N2C(=O)/C(=C/c3ccc(Br)cc3)/C=C2c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K02 compound treatment 167200.0 -5450.0 -0.21 151280.0 -15100.0 -0.57 -0.5502 -0.9098 3119062 ChemDiv3_001278 CCOC(=O)c1cnn(c1N)c2nc(C)cc(C)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K03 compound treatment 167200.0 -5450.0 -0.21 171400.0 5030.0 0.19 -0.0163 -0.0574 1164643 ChemDiv3_001279 Cc1nn(c(C)c1Sc2n[nH]c(=O)[nH]c2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K04 compound treatment 81560.0 -91100.0 -3.53 45520.0 -121000.0 -4.54 -5.7066 -0.9924 3119063 ChemDiv3_001280 Cc1ccc2nc(Nc3ccccc3)nc(c4ccccc4)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K05 compound treatment 174480.0 1830.0 0.07 173960.0 7590.0 0.28 0.2514 0.857 1371214 ChemDiv3_001281 CCOC(=O)c1cnn(c1NC(=O)c2ccccc2F)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K06 compound treatment 178560.0 5910.0 0.23 177440.0 11100.0 0.42 0.4557 0.9607 3020371 ChemDiv3_001282 COC(=O)C(C)Sc1nnc(o1)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K07 compound treatment 182240.0 9590.0 0.37 180000.0 13600.0 0.51 0.6246 0.9878 3119064 ChemDiv3_001283 Cc1nc(cs1)c2c(oc3cc(O)ccc3c2=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K08 compound treatment 207080.0 34400.0 1.34 200680.0 34300.0 1.29 1.8549 0.9998 3020374 ChemDiv3_001284 Brc1ccc(cc1)n2c(nc(=S)c3CCCCc32)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K09 compound treatment 241040.0 68400.0 2.65 204280.0 37900.0 1.42 2.8822 0.9573 3119065 ChemDiv3_001285 CSc1nnc(c(=O)n1/N=C/c2c(O)ccc3ccccc23)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K10 compound treatment 18040.0 -155000.0 -6.0 17600.0 -149000.0 -5.58 -8.1903 -0.9994 3020376 ChemDiv3_001286 CCN(CC)C(=O)[n+]1ccc(OC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K11 compound treatment 157320.0 -15300.0 -0.59 166040.0 -335.0 -0.01 -0.4296 -0.7219 1516068 ChemDiv3_001287 CCCOC(=O)C1=C(C)N(CC)C(=O)NC1c2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K12 compound treatment 40040.0 -133000.0 -5.15 27280.0 -139000.0 -5.22 -7.3298 -1.0 3119198 ChemDiv3_001288 CCOC(=O)c1ccc(cc1)n2c(C)cc(C=C3C(=O)NC(=S)NC3=O)c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K13 compound treatment 59320.0 -113000.0 -4.4 72720.0 -93700.0 -3.52 -5.5949 -0.9938 3119199 ChemDiv3_001289 Cc1ccc(/C=N/c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K14 compound treatment 175000.0 2350.0 0.09 166720.0 345.0 0.01 0.0735 0.7996 3020408 ChemDiv3_001290 COC(=O)C1=C(C)N=c2s/c(=C/c3ccc(OC)cc3)/c(=O)n2C1c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K15 compound treatment 180760.0 8110.0 0.31 174000.0 7630.0 0.29 0.4248 0.9989 1548396 ChemDiv3_001291 CC(C)(C)C(O)Cn1c(=N)n(CCN2CCCCC2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K16 compound treatment 193000.0 20300.0 0.79 183720.0 17300.0 0.65 1.0185 0.9954 3020412 ChemDiv3_001292 CC1=NN(C(=O)c2ccc(Cl)cc2)C(C)(C)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K17 compound treatment 17400.0 -155000.0 -6.02 16920.0 -149000.0 -5.61 -8.2259 -0.9994 3119200 ChemDiv3_001293 Brc1cccc(c1)C2CC(=O)c3c(N2)ccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K18 compound treatment 159880.0 -12800.0 -0.5 215440.0 49100.0 1.84 0.9517 0.499 1559376 ChemDiv3_001294 CCCCN1CCc2c([nH]c3c(C)cccc23)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K19 compound treatment 198120.0 25500.0 0.99 177800.0 11400.0 0.43 1.0019 0.9302 3119201 ChemDiv3_001295 CCN1C(=O)/C(=C/2\SC(=S)N(C2=O)c3ccc(OC)cc3)/c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K20 compound treatment 179440.0 6790.0 0.26 174680.0 8310.0 0.31 0.4066 0.9965 1381466 ChemDiv3_001296 COc1ccc(cc1)n2c(nc3cc4OCOc4cc23)c5ccc(Br)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K21 compound treatment 168800.0 -3850.0 -0.15 175200.0 8830.0 0.33 0.1285 0.3535 1048818 ChemDiv3_001297 O=C(Oc1ccccc1)C(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K22 compound treatment 209000.0 36300.0 1.41 163400.0 -2980.0 -0.11 0.9182 0.6491 1302006 ChemDiv3_001298 CCc1nc(C)cn1S(=O)(=O)c2cc(OC)ccc2OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K23 mock treatment 171640.0 -1010.0 -0.04 157760.0 -8620.0 -0.32 -0.2564 -0.7873 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 K24 mock treatment 180800.0 8150.0 0.32 169520.0 3150.0 0.12 0.307 0.9098 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L01 compound treatment 152400.0 -20300.0 -0.79 127760.0 -38600.0 -1.45 -1.5805 -0.9587 3119202 ChemDiv3_001299 CN1/C(=C(\C#N)/C(=O)c2ccccc2NS(=O)(=O)c3ccc(C)cc3)/Nc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L02 compound treatment 187080.0 14400.0 0.56 184440.0 18100.0 0.68 0.8752 0.9955 1913204 ChemDiv3_001300 OC(=O)/C=C/c1ccc(o1)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L03 compound treatment 175440.0 2790.0 0.11 142560.0 -23800.0 -0.89 -0.5556 -0.6171 1267306 ChemDiv3_001301 Clc1ccc(OCC(=O)NCc2n[nH]c(=S)n2c3cccc(Cl)c3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L04 compound treatment 151320.0 -21300.0 -0.83 144280.0 -22100.0 -0.83 -1.1717 -1.0 1204085 ChemDiv3_001302 O=C1CC(CC(=C1)NC2CCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L05 compound treatment 178400.0 5750.0 0.22 174320.0 7950.0 0.3 0.3685 0.9897 3119203 ChemDiv3_001303 Fc1ccccc1N/C=C(\C#N)/c2nc(cs2)c3cc4ccccc4oc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L06 compound treatment 186280.0 13600.0 0.53 155520.0 -10900.0 -0.41 0.0858 0.1285 3119204 ChemDiv3_001304 O=C/1N\C(=N\S(=O)(=O)c2ccccc2)\S\C1=C/3\C(=O)Nc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L07 compound treatment 185240.0 12600.0 0.49 161880.0 -4500.0 -0.17 0.226 0.4375 3020464 ChemDiv3_001305 CC1(C)CC(=O)C(=CNCc2ccc(F)cc2)C(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L08 compound treatment 196440.0 23800.0 0.92 165360.0 -1020.0 -0.04 0.6257 0.6773 1301856 ChemDiv3_001306 OC(=O)c1ccc(CN2C(=O)c3ccc(cc3C2=O)C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L09 compound treatment 175440.0 2790.0 0.11 195440.0 29100.0 1.09 0.8478 0.7734 1358651 ChemDiv3_001307 OC1(N(CCc2ccccc2)C(=O)c3ccccc31)c4ncc[nH]4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L10 compound treatment 223040.0 50400.0 1.95 199800.0 33400.0 1.25 2.2695 0.977 3119205 ChemDiv3_001308 O=C(CN1C2=NCCCN2c3ccccc13)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L11 compound treatment 166600.0 -6050.0 -0.23 169080.0 2710.0 0.1 -0.0943 -0.3685 1633574 ChemDiv3_001309 CC1=C(C)CC(C(C1)C(=O)O)C(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L12 compound treatment 26800.0 -146000.0 -5.66 26800.0 -140000.0 -5.24 -7.7058 -0.9993 1136469 ChemDiv3_001310 Sc1nc2sc3CCCc3c2c(=O)n1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L13 compound treatment 184560.0 11900.0 0.46 182800.0 16400.0 0.62 0.7626 0.9899 1155907 ChemDiv3_001311 CC(C)CC(N1C(=O)c2ccccc2C1=O)C(=O)Oc3ccc4c5CCCc5c(=O)oc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L14 compound treatment 160840.0 -11800.0 -0.46 150720.0 -15700.0 -0.59 -0.7396 -0.9925 1677666 ChemDiv3_001312 CCN(c1nc(C)cc(OC)n1)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L15 compound treatment 194280.0 21600.0 0.84 141880.0 -24500.0 -0.92 -0.0567 -0.0456 3119206 ChemDiv3_001313 COc1cc2cc(C)nc(Cc3cccc4ccccc34)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L16 compound treatment 167360.0 -5290.0 -0.21 164000.0 -2380.0 -0.09 -0.2083 -0.9302 3020469 ChemDiv3_001314 CCCOC(=O)Nc1cccc(c1)C(=O)OCCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L17 compound treatment 161520.0 -11100.0 -0.43 146000.0 -20400.0 -0.76 -0.8462 -0.9635 3119207 ChemDiv3_001315 Cc1ccc(cc1)c2csc(NC(=O)/C=C/c3ccco3)c2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L18 compound treatment 186880.0 14200.0 0.55 178640.0 12300.0 0.46 0.7158 0.9959 1128259 ChemDiv3_001316 CCOc1ccc(NC(=O)C2c3ccccc3Oc4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L19 compound treatment 141440.0 -31200.0 -1.21 141000.0 -25400.0 -0.95 -1.5298 -0.9929 3119208 ChemDiv3_001317 CN/1C(=O)CC(S\C1=N\c2ccc(I)cc2)C(=O)NCCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L20 compound treatment 183760.0 11100.0 0.43 68600.0 -97800.0 -3.67 -2.2901 -0.6198 1229602 ChemDiv3_001318 Cc1ccc(cc1C(=O)Oc2cccc3cccnc23)S(=O)(=O)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L21 compound treatment 183240.0 10600.0 0.41 168360.0 1990.0 0.07 0.3431 0.8219 1681096 ChemDiv3_001319 COc1cccc(C(O)c2nccn2C)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L22 compound treatment 171880.0 -774.0 -0.03 178640.0 12300.0 0.46 0.3043 0.6596 1212845 ChemDiv3_001320 CCn1c(C)nc2c(=O)oc3ccccc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L23 mock treatment 161000.0 -11700.0 -0.45 163760.0 -2620.0 -0.1 -0.3891 -0.841 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 L24 mock treatment 187480.0 14800.0 0.58 160240.0 -6140.0 -0.23 0.244 0.3937 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M01 compound treatment 183720.0 11100.0 0.43 177600.0 11200.0 0.42 0.6015 1.0 3119209 ChemDiv3_001321 O=C/1N(C2CCCCC2)C(=S)S\C1=C/c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M02 compound treatment 186880.0 14200.0 0.55 165280.0 -1100.0 -0.04 0.3612 0.6527 3119210 ChemDiv3_001322 COC(=O)CN1C(c2ccccc2)c3cc(C)ccc3N=C1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M03 compound treatment 179520.0 6870.0 0.27 168000.0 1630.0 0.06 0.2315 0.8471 3020541 ChemDiv3_001323 Clc1ccc(/C=C/2\SC(=O)N(Cc3ccccc3)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M04 compound treatment 106200.0 -66500.0 -2.58 86080.0 -80300.0 -3.01 -3.9542 -0.997 3119211 ChemDiv3_001324 NNc1nc(c2ccccc2)c3cc(Cl)ccc3n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M05 compound treatment 188640.0 16000.0 0.62 159720.0 -6660.0 -0.25 0.262 0.3918 3020543 ChemDiv3_001325 CC1=Nc2ccc(Br)cc2C(N1CC(=O)NN)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M06 compound treatment 168320.0 -4330.0 -0.17 168760.0 2390.0 0.09 -0.0556 -0.2919 1584812 ChemDiv3_001326 CC(C(Cc1cc(C)cc(C)c1)C(=O)O)C(=O)NCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M07 compound treatment 150760.0 -21900.0 -0.85 141480.0 -24900.0 -0.93 -1.2614 -0.9989 1680758 ChemDiv3_001327 CCOC(=O)C(C)Oc1ccc2c(=O)c(coc2c1)c3csc(C)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M08 compound treatment 207920.0 35300.0 1.37 191040.0 24700.0 0.93 1.6221 0.9819 3020614 ChemDiv3_001328 Cn1/c(=N/C(=O)c2ccc(F)cc2)/sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M09 compound treatment 204200.0 31500.0 1.22 191760.0 25400.0 0.95 1.5392 0.9923 1701030 ChemDiv3_001329 C1OC(OCC12COC(OC2)c3cccnc3)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M10 compound treatment 221640.0 49000.0 1.9 197960.0 31600.0 1.19 2.1822 0.9742 1243322 ChemDiv3_001330 COC(=O)c1cc(ccc1Cl)N2C(=O)C3C4OC(C)(C=C4)C3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M11 compound treatment 170560.0 -2090.0 -0.08 180640.0 14300.0 0.54 0.3211 0.593 3119212 ChemDiv3_001331 CC(=O)N/C(=C\c1ccccc1)/C(=O)Nc2cccc(C#N)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M12 compound treatment 176320.0 3670.0 0.14 200240.0 33900.0 1.27 0.9993 0.7814 1297939 ChemDiv3_001332 OC(=O)c1cc(NC(=O)Cc2cccs2)cc(c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M13 compound treatment 76120.0 -96500.0 -3.75 47040.0 -119000.0 -4.48 -5.8155 -0.996 1112646 ChemDiv3_001333 Clc1ccc(cc1)C(=O)Nc2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M14 compound treatment 173440.0 786.0 0.03 189520.0 23100.0 0.87 0.6358 0.7315 1527595 ChemDiv3_001334 O=C1CSC(N1C2CCCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M15 compound treatment 177080.0 4430.0 0.17 166280.0 -95.0 0.0 0.1189 0.6923 1359293 ChemDiv3_001335 CCCn1c(=N)n(CC(O)c2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M16 compound treatment 176360.0 3710.0 0.14 178760.0 12400.0 0.46 0.4304 0.8845 1703127 ChemDiv3_001336 Cc1nn(C(CC(=O)O)C(=O)O)c(C)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M17 compound treatment 156320.0 -16300.0 -0.63 180960.0 14600.0 0.55 -0.0611 -0.0729 3119213 ChemDiv3_001337 Cc1ccccc1C2CC(=O)c3c(N2)ccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M18 compound treatment 182360.0 9710.0 0.38 176600.0 10200.0 0.38 0.5377 1.0 3020623 ChemDiv3_001338 CCCCN1C(=O)/C(=C\2/Sc3ccc(OC)cc3N2C)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M19 compound treatment 164400.0 -8250.0 -0.32 151880.0 -14500.0 -0.54 -0.6111 -0.9681 1127450 ChemDiv3_001339 COC(=O)c1c(NC(=O)c2c(C)onc2c3ccccc3Cl)sc4CCCCc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M20 compound treatment 185520.0 12900.0 0.5 178320.0 11900.0 0.45 0.67 0.9986 1635195 ChemDiv3_001340 COc1ccc(NC(=O)Nc2c(SC)nsc2SC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M21 compound treatment 132280.0 -40400.0 -1.57 142240.0 -24100.0 -0.91 -1.7482 -0.9661 3119214 ChemDiv3_001341 Nc1ccc(cc1)C(=O)OCCCc2nc3cc4ccccc4cc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M22 compound treatment 197440.0 24800.0 0.96 169080.0 2710.0 0.1 0.7518 0.7774 1632781 ChemDiv3_001342 Cc1ccc(c(C)c1)S(=O)(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M23 mock treatment 171880.0 -774.0 -0.03 169120.0 2750.0 0.1 0.0516 0.481 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 M24 mock treatment 176880.0 4230.0 0.16 158800.0 -7580.0 -0.28 -0.0851 -0.2592 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N01 compound treatment 165680.0 -6970.0 -0.27 166120.0 -255.0 -0.01 -0.1981 -0.7317 1638529 ChemDiv3_001343 COC(=O)C1=C(CCS1)NC(=O)c2ccccc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N02 compound treatment 200320.0 27700.0 1.07 197720.0 31300.0 1.18 1.5909 0.999 1175429 ChemDiv3_001344 Cc1c(oc2ccccc12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N03 compound treatment 16480.0 -156000.0 -6.06 14720.0 -152000.0 -5.69 -8.3095 -0.9995 3119343 ChemDiv3_001345 CCOc1cccc(c1)S(=O)(=O)N=C2C=C(C(=O)C(=C2)C(C)(C)C)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N04 compound treatment 168560.0 -4090.0 -0.16 185440.0 19100.0 0.72 0.3936 0.5371 3020687 ChemDiv3_001346 N/C(=N\O)/CSc1nc2ccccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N05 compound treatment 203680.0 31000.0 1.2 175520.0 9150.0 0.34 1.0939 0.8739 1691239 ChemDiv3_001347 CCOC(=O)C1CCCN(Cc2ccccc2)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N06 compound treatment 171040.0 -1610.0 -0.06 159280.0 -7100.0 -0.27 -0.2326 -0.8502 1225871 ChemDiv3_001348 COc1ccc(OCC(=O)N2CCN(CC2)S(=O)(=O)c3ccc(OC)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N07 compound treatment 210120.0 37500.0 1.45 198440.0 32100.0 1.2 1.8789 0.9956 3119344 ChemDiv3_001349 CCOC(=O)c1sc2nc[nH]c(=O)c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N08 compound treatment 185040.0 12400.0 0.48 169000.0 2630.0 0.1 0.4095 0.8347 1528087 ChemDiv3_001350 Cc1cc(C)nc(Nc2ncc(O)n2c3ccc(Cl)c(Cl)c3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N09 compound treatment 188240.0 15600.0 0.6 196040.0 29700.0 1.11 1.2149 0.9589 1141041 ChemDiv3_001351 OC(=O)CCP(=O)(O)CN1CCCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N10 compound treatment 13840.0 -159000.0 -6.16 13240.0 -153000.0 -5.75 -8.4212 -0.9994 1699621 ChemDiv3_001352 Clc1ccc(cc1Cl)C(=O)Cn2c(=N)n(Cc3ccccc3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N11 compound treatment 158800.0 -13900.0 -0.54 185440.0 19100.0 0.72 0.1259 0.1407 3020690 ChemDiv3_001353 CCC1C(=O)NC(=NC1=O)SCC(=O)Nc2ccc(Br)cn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N12 compound treatment 158360.0 -14300.0 -0.55 163280.0 -3100.0 -0.12 -0.4743 -0.837 1287141 ChemDiv3_001354 CC(=O)Nc1ccc(cc1)C(=O)CSc2nc(C)cc(O)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N13 compound treatment 197840.0 25200.0 0.98 200480.0 34100.0 1.28 1.5961 0.9911 1716124 ChemDiv3_001355 Cc1cc(OC(=O)C2COc3ccccc3O2)cc(C)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N14 compound treatment 192920.0 20300.0 0.79 186040.0 19700.0 0.74 1.0779 0.9995 3119345 ChemDiv3_001356 CCN1OCN(C1=N)c2nc(nc(n2)N(C)C)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N15 compound treatment 155800.0 -16900.0 -0.65 144680.0 -21700.0 -0.81 -1.0382 -0.9941 3119346 ChemDiv3_001357 COc1ccc(cc1)c2cc3cc(OC)c(OC)cc3c(Cc4ccccc4)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N16 compound treatment 181560.0 8910.0 0.35 178280.0 11900.0 0.45 0.5603 0.9919 1442772 ChemDiv3_001358 CCOC(=O)c1c[nH]c2c(C)c(Cl)ccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N17 compound treatment 198920.0 26300.0 1.02 335040.0 169000.0 6.33 5.1968 0.8105 3119347 ChemDiv3_001359 Cc1cc(C)c2cccc(NC(=S)NC(=O)/C=C/c3ccccc3)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N18 compound treatment 117920.0 -54700.0 -2.12 148080.0 -18300.0 -0.69 -1.9872 -0.8904 1476763 ChemDiv3_001360 CC1CC(C)CN(C1)C(=O)C2c3ccccc3Oc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N19 compound treatment 192440.0 19800.0 0.77 175240.0 8870.0 0.33 0.7781 0.93 1211865 ChemDiv3_001361 COc1ccc(cc1)N2C(=O)CC(SCC(=O)O)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N20 compound treatment 142680.0 -30000.0 -1.16 141640.0 -24700.0 -0.93 -1.4788 -0.9938 1518987 ChemDiv3_001362 O=C(N1CCCc2ccccc12)c3cccc(c3)S(=O)(=O)NC4CCCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N21 compound treatment 172880.0 226.0 0.01 183120.0 16700.0 0.63 0.4506 0.7169 1331290 ChemDiv3_001363 CC1=C(C(NC(=O)N1)c2ccccc2)C(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N22 compound treatment 175800.0 3150.0 0.12 180920.0 14500.0 0.55 0.4723 0.8444 1486835 ChemDiv3_001364 Cc1nc2c(=O)oc3ccccc3c2n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N23 mock treatment 172200.0 -454.0 -0.02 166400.0 25.0 0.0 -0.0118 -0.6685 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 N24 mock treatment 170120.0 -2530.0 -0.1 169440.0 3070.0 0.12 0.0118 0.0782 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O01 compound treatment 209680.0 37000.0 1.44 140640.0 -25700.0 -0.97 0.3329 0.1923 1423808 ChemDiv3_001365 CCOc1ccc(cc1Br)C(=O)Nc2ccc(NC(=O)c3ccccc3)c(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O02 compound treatment 185560.0 12900.0 0.5 180280.0 13900.0 0.52 0.7231 0.9998 3119348 ChemDiv3_001366 CCN1C(=O)c2cccc3c(NC(=S)NC(=O)c4ccccc4)ccc1c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O03 compound treatment 198880.0 26200.0 1.02 187480.0 21100.0 0.79 1.2796 0.9923 3020430 ChemDiv3_001367 Cc1cccc(NC(=O)CCN2C(=O)/C(=C\c3ccccc3)/SC2=S)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O04 compound treatment 110680.0 -62000.0 -2.4 105200.0 -61200.0 -2.3 -3.3238 -0.9997 1324540 ChemDiv3_001368 CCOc1ccc(NC(=O)NC2(CC3CC4CC(C3)C2)C4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O05 compound treatment 168320.0 -4330.0 -0.17 155520.0 -10900.0 -0.41 -0.407 -0.9234 1278554 ChemDiv3_001369 Clc1cccc(c1)C(=O)NCC(=O)Nc2ccc(Br)cc2C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O06 compound treatment 218960.0 46300.0 1.8 197240.0 30900.0 1.16 2.0896 0.9775 1711492 ChemDiv3_001370 CN1N=C(C(NC(=O)C)C1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O07 compound treatment 129920.0 -42700.0 -1.66 120680.0 -45700.0 -1.72 -2.3851 -0.9999 1278126 ChemDiv3_001371 CC(C)Oc1ccc2c(=O)c(c(C)oc2c1)c3ccc4OCCOc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O08 compound treatment 236360.0 63700.0 2.47 201080.0 34700.0 1.3 2.6689 0.9552 3021156 ChemDiv3_001372 N(=c/1\scc(c2cccs2)n1c3ccccc3)\c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O09 compound treatment 58680.0 -114000.0 -4.42 36080.0 -130000.0 -4.89 -6.5849 -0.9987 3021157 ChemDiv3_001373 FC(F)(F)c1ccccc1/C=C/2\N=C(OC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O10 compound treatment 37680.0 -135000.0 -5.24 43240.0 -123000.0 -4.62 -6.971 -0.9981 3021158 ChemDiv3_001374 COc1ccccc1NC(=O)/C=C\c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O11 compound treatment 69160.0 -103000.0 -4.02 89240.0 -77100.0 -2.9 -4.8865 -0.9871 3119349 ChemDiv3_001375 CCCCn1c(Cc2ccccc2)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O12 compound treatment 187920.0 15300.0 0.59 179960.0 13600.0 0.51 0.7794 0.9972 1533954 ChemDiv3_001376 OC(=O)c1cc(NC(=O)c2cccs2)cc(c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O13 compound treatment 199280.0 26600.0 1.03 194240.0 27900.0 1.05 1.47 1.0 1377349 ChemDiv3_001377 Brc1ccc2oc(=O)c(cc2c1)C(=O)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O14 compound treatment 209920.0 37300.0 1.45 190920.0 24500.0 0.92 1.6738 0.9763 3119350 ChemDiv3_001378 CCOC(=O)CC/1=NN(C(=O)\C1=C/c2cc(OC)c(OC)cc2OC)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O15 compound treatment 130680.0 -42000.0 -1.63 126440.0 -39900.0 -1.5 -2.2114 -0.9991 3021159 ChemDiv3_001379 CCn1c(/C=N/c2ccccc2)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O16 compound treatment 185440.0 12800.0 0.5 181600.0 15200.0 0.57 0.7549 0.9975 1912932 ChemDiv3_001380 CCOC(=O)C1CNN=C1C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O17 compound treatment 183280.0 10600.0 0.41 164800.0 -1580.0 -0.06 0.2497 0.5996 1144944 ChemDiv3_001381 CCOC(=O)c1ccc2nc(ccc2c1)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O18 compound treatment 320160.0 148000.0 5.72 166120.0 -255.0 -0.01 4.0402 0.7059 3021160 ChemDiv3_001382 CCN1/C(=C\C(=S)CC)/Sc2ccc(Cl)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O19 compound treatment 202000.0 29300.0 1.14 181520.0 15100.0 0.57 1.2071 0.9485 1434944 ChemDiv3_001383 Brc1ccc(OCC(=O)NCC2CCCO2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O20 compound treatment 170400.0 -2250.0 -0.09 161200.0 -5180.0 -0.19 -0.1992 -0.9351 1002861 ChemDiv3_001384 CC(Oc1ccccc1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O21 compound treatment 182840.0 10200.0 0.4 181000.0 14600.0 0.55 0.6676 0.987 3119351 ChemDiv3_001385 O=C(Nc1cc2c(ccc3ccccc32)oc1=O)/C=C/c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O22 compound treatment 123840.0 -48800.0 -1.89 120400.0 -46000.0 -1.73 -2.5594 -0.9989 3021161 ChemDiv3_001386 CCOC(=O)/C=C(\C)/Nc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O23 mock treatment 184600.0 11900.0 0.46 169520.0 3150.0 0.12 0.4112 0.8597 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 O24 mock treatment 189800.0 17100.0 0.67 176280.0 9910.0 0.37 0.7333 0.9622 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P01 compound treatment 169400.0 -3250.0 -0.13 142600.0 -23800.0 -0.89 -0.7202 -0.7992 1607061 ChemDiv3_001387 COC(=O)C1=C(CCS1)NC(=O)c2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P02 compound treatment 180200.0 7550.0 0.29 175560.0 9190.0 0.34 0.4508 0.9967 3021162 ChemDiv3_001388 CN1CNC(=NS(=O)(=O)c2ccc(NC(=O)C)cc2)NC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P03 compound treatment 204880.0 32200.0 1.25 170120.0 3750.0 0.14 0.9835 0.7817 1145842 ChemDiv3_001389 CCCCn1c(Br)nc2n(C)c(=O)[nH]c(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P04 compound treatment 178800.0 6150.0 0.24 163040.0 -3340.0 -0.13 0.0801 0.2975 1326168 ChemDiv3_001390 CCOC(=O)c1[nH]c(C(=O)O)c(CC)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P05 compound treatment 11280.0 -161000.0 -6.26 10960.0 -155000.0 -5.83 -8.552 -0.9994 3119352 ChemDiv3_001391 CC1=CC(=O)C=C(C)C1=NS(=O)(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P06 compound treatment 171840.0 -814.0 -0.03 159120.0 -7260.0 -0.27 -0.2149 -0.7838 1659137 ChemDiv3_001392 CC(C)CC(=O)N1CCN(Cc2ccc(Cl)cc2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P07 compound treatment 206480.0 33800.0 1.31 185880.0 19500.0 0.73 1.4457 0.962 1602384 ChemDiv3_001393 COc1cccc(c1)C(=O)NCCN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P08 compound treatment 175680.0 3030.0 0.12 205040.0 38700.0 1.45 1.1092 0.7618 3119353 ChemDiv3_001394 CC1CCc2sc(NC(=O)C(Cc3ccccc3)Cc4ccccc4)c(C#N)c2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P09 compound treatment 8360.0 -164000.0 -6.37 8560.0 -158000.0 -5.92 -8.6958 -0.9993 3021163 ChemDiv3_001395 CCOC(=O)c1c(oc2ccc(O)c(CSCC(=O)Nc3ccccc3)c12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P10 compound treatment 14640.0 -158000.0 -6.13 12080.0 -154000.0 -5.79 -8.4301 -0.9996 3119354 ChemDiv3_001396 Cc1cccc(c1)C(=O)Sc2cccccc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P11 compound treatment 157800.0 -14900.0 -0.58 165080.0 -1300.0 -0.05 -0.4419 -0.764 1345562 ChemDiv3_001397 Cc1ccc(o1)c2c(C#N)c(SCC=C)nc3CCCCc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P12 compound treatment 149600.0 -23100.0 -0.89 156720.0 -9660.0 -0.36 -0.8887 -0.9209 1469960 ChemDiv3_001398 CN1CCN(CCCN2C(SCC2=O)c3ccc(F)cc3)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P13 compound treatment 191960.0 19300.0 0.75 188120.0 21700.0 0.82 1.1068 0.9991 1737932 ChemDiv3_001399 COC(=O)COc1ccc2c(=O)c(coc2c1)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P14 compound treatment 205280.0 32600.0 1.27 213560.0 47200.0 1.77 2.1474 0.9865 1405560 ChemDiv3_001400 Cc1ccc(OCC(O)CN2C(=O)NC(C)(C)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P15 compound treatment 208360.0 35700.0 1.39 207240.0 40900.0 1.53 2.0641 0.9987 1711766 ChemDiv3_001401 CCc1nc(cc2cc(OC)c(OC)cc12)c3ccc(OC)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P16 compound treatment 172000.0 -654.0 -0.03 159440.0 -6940.0 -0.26 -0.202 -0.7724 3021164 ChemDiv3_001402 Cc1ccc(cc1C)S(=O)(=O)N2CCCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P17 compound treatment 202720.0 30100.0 1.17 200240.0 33900.0 1.27 1.7236 0.9991 1435290 ChemDiv3_001403 CC1(C)Cc2c(sc3ncn4nc(nc4c23)c5ccccc5)C(C)(C)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P18 compound treatment 172480.0 -174.0 -0.01 169400.0 3030.0 0.11 0.0755 0.6639 1603940 ChemDiv3_001404 COc1ccccc1NC(=O)C2c3ccccc3Oc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P19 compound treatment 175840.0 3190.0 0.12 178920.0 12500.0 0.47 0.4203 0.8635 3119355 ChemDiv3_001405 CC(C)Oc1ccc(cc1)C2CC(=O)NNC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P20 compound treatment 156080.0 -16600.0 -0.64 155120.0 -11300.0 -0.42 -0.7534 -0.9792 1788078 ChemDiv3_001406 Cc1ccc(cc1S(=O)(=O)N2CCCC2)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P21 compound treatment 158200.0 -14500.0 -0.56 142320.0 -24100.0 -0.9 -1.0349 -0.9738 3021165 ChemDiv3_001407 O=C(NN1C(=O)/C(=C\c2cccnc2)/SC1=S)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P22 compound treatment 188600.0 15900.0 0.62 164760.0 -1620.0 -0.06 0.3946 0.6348 1314274 ChemDiv3_001408 COc1ccc(cc1)n2nc3ccc(NC(=O)c4ccc(cc4)c5ccccc5)cc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P23 mock treatment 175840.0 3190.0 0.12 164160.0 -2220.0 -0.08 0.0286 0.1922 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2004 P24 mock treatment 172240.0 -414.0 -0.02 147400.0 -19000.0 -0.71 -0.5149 -0.7229 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A01 compound treatment 177560.0 17700.0 0.69 188360.0 10600.0 0.4 0.7666 0.9659 3118959 ChemDiv3_003873 COC(=O)C(CC(C)C)N1C=C(C(C(=C1)C(=O)OC)c2ccc(Br)cc2)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A02 compound treatment 184800.0 25000.0 0.97 194520.0 16700.0 0.63 1.1287 0.978 3023755 ChemDiv3_003874 CN(C)c1ccc(cc1)n2cccc2C=C3C(=O)N(C)C(=S)N(C)C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A03 compound treatment 167640.0 7800.0 0.3 173680.0 -4110.0 -0.15 0.1049 0.3087 1344150 ChemDiv3_003875 CSc1nnc-2c(OC(C)Nc3ccccc32)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A04 compound treatment 184480.0 24600.0 0.96 178440.0 649.0 0.02 0.6932 0.7249 3118960 ChemDiv3_003876 O=C(CSc1nnc(COc2ccccc2)o1)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A05 compound treatment 177960.0 18100.0 0.7 183840.0 6050.0 0.23 0.6576 0.8902 3023867 ChemDiv3_003877 CCc1ccc2NC(=O)/C(=C/3\SC(=N)NC3=O)/c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A06 compound treatment 12600.0 -147000.0 -5.71 11920.0 -166000.0 -6.23 -8.4417 -0.9991 1867181 ChemDiv3_003878 CCOC(=O)c1c(C)n(Cc2ccccc2)c3ccc(OCC(O)CNC(C)(C)C)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A07 compound treatment 164280.0 4440.0 0.17 161680.0 -16100.0 -0.6 -0.3058 -0.4864 3118961 ChemDiv3_003879 CCc1ccc(/C=N/n2c(C)nnc2n3nc(C)cc3C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A08 compound treatment 50040.0 -110000.0 -4.26 67640.0 -110000.0 -4.13 -5.9358 -0.9999 1292139 ChemDiv3_003880 O=C(N1c2ccccc2Sc3ccccc13)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A09 compound treatment 166520.0 6680.0 0.26 172680.0 -5110.0 -0.19 0.0476 0.1476 3119097 ChemDiv3_003881 CN1C(=O)/C(=C/2\S\C(=N/c3ccc(F)cc3)\NC2=O)/c4cc(Br)cc(C)c14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A10 compound treatment 180600.0 20800.0 0.81 178480.0 689.0 0.03 0.5878 0.7294 3023868 ChemDiv3_003882 CCCn1c(C)cc(C)c(C#N)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A11 compound treatment 312560.0 153000.0 5.93 194280.0 16500.0 0.62 4.6276 0.7767 3023869 ChemDiv3_003883 CC(Cc1ccccc1)[n+]2[cH-]/c(=N\C(=O)N)/on2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A12 compound treatment 187680.0 27800.0 1.08 244240.0 66400.0 2.49 2.5273 0.9299 1249817 ChemDiv3_003884 COc1cccc(CN2CCN(CC2)C(=O)c3cccs3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A13 compound treatment 229920.0 70100.0 2.72 239120.0 61300.0 2.3 3.5503 0.9966 3119098 ChemDiv3_003885 Cc1ccc(Nc2nnc(c3ccc(C)c(c3)S(=O)(=O)NCC4CCCO4)c5ccccc25)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A14 compound treatment 98880.0 -61000.0 -2.37 95120.0 -82700.0 -3.1 -3.8665 -0.991 3023870 ChemDiv3_003886 C(Cc1c[nH]c2ccccc12)NCc3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A15 compound treatment 180520.0 20700.0 0.8 195640.0 17800.0 0.67 1.041 0.996 1549146 ChemDiv3_003887 Clc1ccc(SCC(=O)Nc2ccc(cc2)c3nc4ncccc4o3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A16 compound treatment 178520.0 18700.0 0.72 179400.0 1610.0 0.06 0.5552 0.7634 3023871 ChemDiv3_003888 CCCN(CCC)C1=C(N(CC(=O)N)S(=O)(=O)c2ccccc12)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A17 compound treatment 181240.0 21400.0 0.83 189200.0 11400.0 0.43 0.8899 0.9526 1118860 ChemDiv3_003889 CCN(CC)CCC(=O)N1N=C(CC1c2ccc(OC)cc2)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A18 compound treatment 206040.0 46200.0 1.79 236400.0 58600.0 2.2 2.8229 0.9948 1173412 ChemDiv3_003890 Cc1cc(C)cc(Oc2coc3cc(OCC(=O)NCc4ccccc4)ccc3c2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A19 compound treatment 182280.0 22400.0 0.87 186160.0 8370.0 0.31 0.8377 0.9051 1387978 ChemDiv3_003891 CN(C)C1CS(=O)(=O)CC1N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A20 compound treatment 125400.0 -34400.0 -1.34 137280.0 -40500.0 -1.52 -2.0201 -0.9979 1867723 ChemDiv3_003892 COc1ccccc1COc2ccc3c4CCCCCc4c(=O)oc3c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A21 compound treatment 171920.0 12100.0 0.47 178560.0 769.0 0.03 0.3518 0.7492 1361724 ChemDiv3_003893 O=C(NCc1ccccc1)NC2CCS(=O)(=O)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A22 compound treatment 13960.0 -146000.0 -5.66 14880.0 -163000.0 -6.11 -8.3259 -0.9993 1233165 ChemDiv3_003894 Cc1oc(cc1COc2ccc3c(C)c(Cc4ccccc4)c(=O)oc3c2C)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A23 mock treatment 238520.0 78700.0 3.05 181800.0 4010.0 0.15 2.265 0.7411 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 A24 mock treatment 203720.0 43900.0 1.7 196120.0 18300.0 0.69 1.6903 0.9205 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B01 compound treatment 180720.0 20900.0 0.81 216360.0 38600.0 1.45 1.5964 0.9624 3119099 ChemDiv3_003895 CN(/N=C/c1ccccc1)C2=NS(=O)(=O)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B02 compound treatment 165200.0 5360.0 0.21 219000.0 41200.0 1.55 1.2407 0.795 3119100 ChemDiv3_003896 COC(=O)C1=C(C)N/C(=C/c2cc(C)n(c2C)c3ccc(OC)c(Cl)c3)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B03 compound treatment 60960.0 -98900.0 -3.84 48720.0 -129000.0 -4.84 -6.1383 -0.9933 3023872 ChemDiv3_003897 COc1cccc(C=C2C(=O)c3ccccc3C2=O)c1OC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B04 compound treatment 171440.0 11600.0 0.45 187080.0 9290.0 0.35 0.5647 0.992 3023873 ChemDiv3_003898 Cc1ccc(cc1)c2c[n+]([O-])c3CCCc3[n+]2[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B05 compound treatment 144400.0 -15400.0 -0.6 169440.0 -8350.0 -0.31 -0.6453 -0.9543 3119101 ChemDiv3_003899 O=c1[nH]c2ccccc2n1CCCSc3nc4ccccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B06 compound treatment 187360.0 27500.0 1.07 243960.0 66200.0 2.48 2.5111 0.9289 1401658 ChemDiv3_003900 CCOC(=O)c1c(oc2ccc(OCC(=O)OC)cc12)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B07 compound treatment 173960.0 14100.0 0.55 185240.0 7450.0 0.28 0.585 0.9513 1210771 ChemDiv3_003901 CC(C)Cn1c(=O)c2cc3c(=O)n(CC(C)C)c(=O)c3c(C(=O)c4ccc(Cl)cc4)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B08 compound treatment 106400.0 -53400.0 -2.07 116000.0 -61800.0 -2.32 -3.1061 -0.9984 1511593 ChemDiv3_003902 CC1CCN(CC1)S(=O)(=O)c2ccc(NC(=O)c3ccc(cc3)C(C)(C)C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B09 compound treatment 74640.0 -85200.0 -3.31 45120.0 -133000.0 -4.98 -5.8585 -0.9802 1487762 ChemDiv3_003903 O=S(=O)(NCCC1(CC2CC3CC(C2)C1)C3)c4cccc5nsnc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B10 compound treatment 170600.0 10800.0 0.42 199040.0 21200.0 0.8 0.8591 0.9544 3023874 ChemDiv3_003904 COc1cc(/C=C\2/C(=N)N3C=CSC3=NC2=O)cc(OC)c1OCCOc4ccc(C)c(C)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B11 compound treatment 186160.0 26300.0 1.02 155640.0 -22200.0 -0.83 0.1342 0.1019 3119102 ChemDiv3_003905 CN(C)/C=N/c1c(C#N)cnn1c2ncnc3sc4CCCc4c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B12 compound treatment 182240.0 22400.0 0.87 186120.0 8330.0 0.31 0.8356 0.9047 3023875 ChemDiv3_003906 COc1ccc2N3C(=NC(=O)C(Cc4ccccc4)C3=O)Sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B13 compound treatment 168600.0 8760.0 0.34 170160.0 -7630.0 -0.29 0.0378 0.085 1072961 ChemDiv3_003907 O=c1n(Cc2ccccc2)nc(c3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B14 compound treatment 14160.0 -146000.0 -5.65 99360.0 -78400.0 -2.94 -6.0784 -0.9538 1739914 ChemDiv3_003908 Clc1ccc(cc1)S(=O)(=O)Nc2nc3ccccc3nc2NCCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B15 compound treatment 153560.0 -6280.0 -0.24 173040.0 -4750.0 -0.18 -0.2984 -0.9882 3023876 ChemDiv3_003909 C(Sc1nc2ccccc2[nH]1)/C=C/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B16 compound treatment 13120.0 -147000.0 -5.69 15040.0 -163000.0 -6.11 -8.3447 -0.9994 1325550 ChemDiv3_003910 NC1=C(C#N)C(c2sc3ccccc3c2O1)c4ccccc4OC(=O)c5ccccc5Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B17 compound treatment 165160.0 5320.0 0.21 194200.0 16400.0 0.62 0.5814 0.8951 3023877 ChemDiv3_003911 CC(C)OC(=O)C1=c2s/c(=C\c3cccnc3)/c(=O)n2C(=C(C#N)C1c4cccnc4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B18 compound treatment 159400.0 -441.0 -0.02 172240.0 -5550.0 -0.21 -0.1594 -0.7626 3119103 ChemDiv3_003912 COc1ccc(CN2C(=O)CC(Cc3ccc(C)cc3)C2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B19 compound treatment 121040.0 -38800.0 -1.51 116120.0 -61700.0 -2.31 -2.7012 -0.9783 1408601 ChemDiv3_003913 COc1ccc(CCNc2ncnc3sc4CCCCc4c23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B20 compound treatment 171320.0 11500.0 0.45 191560.0 13800.0 0.52 0.6803 0.9973 3023878 ChemDiv3_003914 N=C1NC(=O)/C(=C\c2cc3ccccc3nc2N4CCCCC4)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B21 compound treatment 177680.0 17800.0 0.69 191360.0 13600.0 0.51 0.8495 0.9886 1543973 ChemDiv3_003915 COc1ccc2CNCCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B22 compound treatment 164520.0 4680.0 0.18 171440.0 -6350.0 -0.24 -0.0402 -0.1341 3119104 ChemDiv3_003916 CC1CCN(CN2CC(COc3ccccc3C)OC2=O)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B23 mock treatment 165080.0 5240.0 0.2 188000.0 10200.0 0.38 0.4147 0.956 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 B24 mock treatment 175880.0 16000.0 0.62 175880.0 -1910.0 -0.07 0.3893 0.6215 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C01 compound treatment 151120.0 -8720.0 -0.34 187800.0 10000.0 0.38 0.0263 0.0521 3119105 ChemDiv3_003917 COC(=O)C1=CN(C=C(C1c2ccsc2)C(=O)OC)c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C02 compound treatment 159120.0 -721.0 -0.03 200520.0 22700.0 0.85 0.5834 0.6835 3023910 ChemDiv3_003918 Cn1c(=O)n(C)c2cc(/C=C/3\C(=O)NC(=S)N(CC=C)C3=O)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C03 compound treatment 179160.0 19300.0 0.75 192440.0 14600.0 0.55 0.9188 0.9884 3119106 ChemDiv3_003919 CSC1=N/C(=C\c2ccccc2C)/C(=O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C04 compound treatment 159440.0 -401.0 -0.02 170960.0 -6830.0 -0.26 -0.1923 -0.7487 3119107 ChemDiv3_003920 COc1ccc(CCCc2nnc(SCC(=O)Nc3cc(F)ccc3C)o2)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C05 compound treatment 121720.0 -38100.0 -1.48 165840.0 -12000.0 -0.45 -1.3631 -0.8819 3023911 ChemDiv3_003921 C=CCN1C(=O)/C(=C/2\S/C(=N\c3ccccc3)/N(C2=O)c4ccccc4)/c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C06 compound treatment 154200.0 -5640.0 -0.22 194320.0 16500.0 0.62 0.2839 0.4315 1871099 ChemDiv3_003922 Cc1cccc(c1)N2C(=O)CC(Sc3nccc(C)n3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C07 compound treatment 38320.0 -122000.0 -4.72 52560.0 -125000.0 -4.7 -6.6576 -1.0 3023912 ChemDiv3_003923 CSC1=N/C(=C\C=C\c2cccs2)/C(=O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C08 compound treatment 117120.0 -42700.0 -1.66 126640.0 -51200.0 -1.92 -2.5296 -0.9973 1871152 ChemDiv3_003924 O=C(Cc1cccs1)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C09 compound treatment 239680.0 79800.0 3.1 217480.0 39700.0 1.49 3.2437 0.9437 3023913 ChemDiv3_003925 CCSC1=N/C(=C\c2ccc(C)s2)/C(=O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C10 compound treatment 134720.0 -25100.0 -0.97 92200.0 -85600.0 -3.21 -2.9607 -0.882 3119108 ChemDiv3_003926 CCCN1C(=O)/C(=C/c2ccc(o2)c3ccc(Cl)cc3)/C(=C(C#N)C1=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C11 compound treatment 171920.0 12100.0 0.47 193480.0 15700.0 0.59 0.7478 0.9936 3023914 ChemDiv3_003927 N=c1[cH-][n+](CCc2ccccc2)no1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C12 compound treatment 150360.0 -9480.0 -0.37 165960.0 -11800.0 -0.44 -0.5741 -0.9956 1216628 ChemDiv3_003928 CCOc1cc(CN2CCN(CC2)C(=O)COc3ccc(C)cc3)ccc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C13 compound treatment 115480.0 -44400.0 -1.72 117200.0 -60600.0 -2.27 -2.8251 -0.9906 3023915 ChemDiv3_003929 COc1ccc(cc1)c2nnc(Nc3cccc(c3)C(F)(F)F)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C14 compound treatment 173280.0 13400.0 0.52 167800.0 -9990.0 -0.37 0.1035 0.1612 3119109 ChemDiv3_003930 COc1cccc(CNCCc2c[nH]c3ccccc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C15 compound treatment 15240.0 -145000.0 -5.61 16760.0 -161000.0 -6.04 -8.2409 -0.9993 1485768 ChemDiv3_003931 CCC(=O)NC(c1ccco1)c2cc(Cl)c3cccnc3c2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C16 compound treatment 159640.0 -201.0 -0.01 168320.0 -9470.0 -0.36 -0.2569 -0.7225 1522564 ChemDiv3_003932 Cc1nc(NCCN2CCOCC2)c3sc4nc5CC(C)(C)OCc5cc4c3n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C17 compound treatment 196080.0 36200.0 1.41 209640.0 31800.0 1.2 1.8395 0.9967 3119239 ChemDiv3_003933 COc1ccc(cc1)C2CC(=NN2C(=O)CCN3CCOCC3)c4ccc(Br)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C18 compound treatment 134720.0 -25100.0 -0.97 141360.0 -36400.0 -1.37 -1.6561 -0.9862 1139781 ChemDiv3_003934 CC(C)COC(=O)c1ccc2NC(C3CC=CC3c2c1)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C19 compound treatment 187840.0 28000.0 1.09 207920.0 30100.0 1.13 1.5678 0.9998 1505314 ChemDiv3_003935 O=S1(=O)CCC(C1)N2C(=S)SC3CS(=O)(=O)C=C32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C20 compound treatment 177000.0 17200.0 0.67 197440.0 19600.0 0.74 0.9922 0.9987 1867708 ChemDiv3_003936 COc1cc(COc2ccc3c4CCCc4c(=O)oc3c2)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C21 compound treatment 172680.0 12800.0 0.5 197680.0 19900.0 0.75 0.8801 0.9807 1172275 ChemDiv3_003937 CC1(CCS(=O)(=O)C1)NC(=S)Nc2ccc(O)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C22 compound treatment 157400.0 -2440.0 -0.09 168480.0 -9310.0 -0.35 -0.3141 -0.8675 1132860 ChemDiv3_003938 CN(C)C(=O)COc1cc2oc(=O)c3CCCc3c2cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C23 mock treatment 179160.0 19300.0 0.75 174360.0 -3430.0 -0.13 0.439 0.5772 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 C24 mock treatment 174440.0 14600.0 0.57 178160.0 369.0 0.01 0.4103 0.7242 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D01 compound treatment 178880.0 19000.0 0.74 187680.0 9890.0 0.37 0.7848 0.9493 3023916 ChemDiv3_003939 O=S1(=O)N=C(N(CCC#N)/N=C/c2ccccc2)c3ccccc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D02 compound treatment 167120.0 7280.0 0.28 167760.0 -10000.0 -0.38 -0.0665 -0.1413 3119240 ChemDiv3_003940 COC(=O)C/1=C(C)NC(=O)\C1=C\c2ccc(CNS(=O)(=O)c3ccc(Cl)cc3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D03 compound treatment 76280.0 -83600.0 -3.24 150560.0 -27200.0 -1.02 -3.0153 -0.887 3023917 ChemDiv3_003941 CCC(C)N1C(=O)S/C(=C/c2ccc3n(C)c(=O)n(C)c3c2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D04 compound treatment 155320.0 -4520.0 -0.18 166560.0 -11200.0 -0.42 -0.4221 -0.9245 3119241 ChemDiv3_003942 [O-][n+]1cc(c2ccc(F)cc2)[n+]([O-])c3CCCc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D05 compound treatment 148040.0 -11800.0 -0.46 143600.0 -34200.0 -1.28 -1.2312 -0.9036 3119242 ChemDiv3_003943 CCC(Sc1nnnn1c2ccccc2)C(=O)Nc3sc4CCCCc4c3C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D06 compound treatment 146560.0 -13300.0 -0.52 182040.0 4250.0 0.16 -0.2516 -0.4665 3023918 ChemDiv3_003944 CCCCc1c(O)nc(SCC(=O)N2CCCCC2)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D07 compound treatment 24560.0 -135000.0 -5.25 19840.0 -158000.0 -5.93 -7.9034 -0.9982 3119243 ChemDiv3_003945 COc1ccccc1CC(=O)Nc2ccc(cc2)c3nc4ccccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D08 compound treatment 173000.0 13200.0 0.51 175960.0 -1830.0 -0.07 0.3124 0.6064 3023919 ChemDiv3_003946 OC(Cn1c2ccccc2c3ccccc13)C[n+]4cccc5cccc(O)c45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D09 compound treatment 166240.0 6400.0 0.25 176880.0 -911.0 -0.03 0.1514 0.604 3119244 ChemDiv3_003947 Nc1nc(SCC(=O)NCc2ccco2)c(C#N)cc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D10 compound treatment 141560.0 -18300.0 -0.71 158840.0 -19000.0 -0.71 -1.0045 -1.0 3119245 ChemDiv3_003948 COc1ccccc1N(C(=O)NCc2ccccc2)C3=NCC(C)S3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D11 compound treatment 131200.0 -28600.0 -1.11 132600.0 -45200.0 -1.7 -1.9851 -0.979 1494926 ChemDiv3_003949 Cc1ccc(cc1)c2nnc(n3cnc4cc(C)c(C)cc34)c5ccccc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D12 compound treatment 248680.0 88800.0 3.45 229720.0 51900.0 1.95 3.8155 0.9636 1647264 ChemDiv3_003950 CCc1nc2oc(C(=O)c3ccccc3)c(N)c2c4CC(C)(C)OCc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D13 compound treatment 191840.0 32000.0 1.24 182600.0 4810.0 0.18 1.0055 0.8015 1516394 ChemDiv3_003951 Cc1nc(Oc2ccc(NC(=O)c3ccccc3)cc2)c4c5CCCc5sc4n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D14 compound treatment 148240.0 -11600.0 -0.45 156480.0 -21300.0 -0.8 -0.8839 -0.963 1736266 ChemDiv3_003952 CCc1ccc(Nc2nc3ccccc3nc2NS(=O)(=O)c4ccc(C)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D15 compound treatment 166640.0 6800.0 0.26 189400.0 11600.0 0.44 0.4946 0.9711 1623664 ChemDiv3_003953 C(N1CCc2ccccc2C1)n3cnc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D16 compound treatment 183240.0 23400.0 0.91 191840.0 14000.0 0.53 1.0148 0.9666 1684726 ChemDiv3_003954 COc1ccccc1NC(=O)COc2ccc3oc4CCCCc4c3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D17 compound treatment 163520.0 3680.0 0.14 182040.0 4250.0 0.16 0.2137 0.9985 1574911 ChemDiv3_003955 NC1=C(C#N)C2(C(=O)N(CC=C)c3ccccc32)c4c(O1)c5ccccc5oc4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D18 compound treatment 167800.0 7960.0 0.31 176000.0 -1790.0 -0.07 0.1708 0.5405 1249386 ChemDiv3_003956 O=C1CC(Cc2ccccc2)C(=O)N1c3nccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D19 compound treatment 185240.0 25400.0 0.99 175280.0 -2510.0 -0.09 0.6302 0.6366 1153670 ChemDiv3_003957 Cc1sc2nc3c4ccccc4c(NCC5CCCO5)nn3c(=O)c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D20 compound treatment 163760.0 3920.0 0.15 186000.0 8210.0 0.31 0.3254 0.947 3119246 ChemDiv3_003958 CC(=O)N1C(=N)S/C(=C/c2cc3ccccc3nc2Sc4ccccc4)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D21 compound treatment 134800.0 -25000.0 -0.97 152600.0 -25200.0 -0.95 -1.3556 -0.9999 1736305 ChemDiv3_003959 CC(C)COc1ccc2c3CCCCc3c(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D22 compound treatment 146680.0 -13200.0 -0.51 164240.0 -13600.0 -0.51 -0.7207 -1.0 3023957 ChemDiv3_003960 CC1CCN(CN2CC(Cn3c4ccccc4c5ccccc35)OC2=O)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D23 mock treatment 150600.0 -9240.0 -0.36 190080.0 12300.0 0.46 0.0726 0.1243 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 D24 mock treatment 165360.0 5520.0 0.21 182400.0 4610.0 0.17 0.2737 0.9944 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E01 compound treatment 168920.0 9080.0 0.35 177000.0 -791.0 -0.03 0.2281 0.6452 3119247 ChemDiv3_003961 COC(=O)CN1C=C(C(C(=C1)C(=O)OC)c2ccc(O)cc2)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E02 compound treatment 18000.0 -142000.0 -5.5 23680.0 -154000.0 -5.78 -7.9815 -0.9997 3119248 ChemDiv3_003962 CCC(C)n1cc(/C=C/2\C(=O)NC(=S)N(CC=C)C2=O)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E03 compound treatment 89720.0 -70100.0 -2.72 146440.0 -31400.0 -1.18 -2.7559 -0.9297 3023958 ChemDiv3_003963 O=C/1N=C(S\C1=C/c2cccs2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E04 compound treatment 166240.0 6400.0 0.25 191320.0 13500.0 0.51 0.5346 0.9458 3023959 ChemDiv3_003964 O=C(CSc1nnc(COc2ccccc2)o1)NCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E05 compound treatment 146920.0 -12900.0 -0.5 164560.0 -13200.0 -0.5 -0.7057 -1.0 3119249 ChemDiv3_003965 CN/1C(=N)NC(=O)\C1=C\c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E06 compound treatment 149080.0 -10800.0 -0.42 217200.0 39400.0 1.48 0.7506 0.4884 1871115 ChemDiv3_003966 CC(C)(CO)NC(=O)c1sc2ccccc2c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E07 compound treatment 127720.0 -32100.0 -1.25 183200.0 5410.0 0.2 -0.7377 -0.5842 3023960 ChemDiv3_003967 C(Sc1nnc-2c(OC(Nc3ccccc32)/C=C/c4ccco4)n1)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E08 compound treatment 162560.0 2720.0 0.11 191080.0 13300.0 0.5 0.4273 0.8381 3119250 ChemDiv3_003968 Cc1ccc(SCc2cc(O)nc(SCC(=O)n3c4ccccc4c5ccccc35)n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E09 compound treatment 189960.0 30100.0 1.17 247960.0 70200.0 2.63 2.6885 0.9331 3023961 ChemDiv3_003969 CCSC1=N/C(=C\c2cccc(F)c2)/C(=O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E10 compound treatment 163160.0 3320.0 0.13 171840.0 -5950.0 -0.22 -0.0669 -0.2594 1156555 ChemDiv3_003970 CC1CCN(CC1)C(=O)CNS(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E11 compound treatment 171840.0 12000.0 0.47 200080.0 22300.0 0.84 0.9207 0.9617 1664682 ChemDiv3_003971 Cc1n[nH]c(C)c1N2C(=O)c3cccc4c(N)ccc(C2=O)c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E12 compound treatment 164600.0 4760.0 0.18 185880.0 8090.0 0.3 0.3452 0.9716 1473240 ChemDiv3_003972 O=C(N1CCN(Cc2cccnc2)CC1)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E13 compound treatment 222880.0 63000.0 2.45 218880.0 41100.0 1.54 2.82 0.9753 3119251 ChemDiv3_003973 CNS(=O)(=O)c1cc(ccc1C)c2nnc(Nc3ccc4OCOc4c3)c5ccccc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E14 compound treatment 156080.0 -3760.0 -0.15 144040.0 -33800.0 -1.27 -0.9989 -0.7834 1668191 ChemDiv3_003974 CCOc1ccc(CN(CCc2ccc3OCOc3c2)Cc4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E15 compound treatment 182120.0 22300.0 0.86 238360.0 60600.0 2.27 2.2187 0.9123 1243341 ChemDiv3_003975 COc1ccc2cc(C3CC(=NN3C(=O)c4ccco4)c5ccc(OC)c(OC)c5)c(Cl)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E16 compound treatment 15200.0 -145000.0 -5.61 18280.0 -160000.0 -5.99 -8.2016 -0.9995 3023962 ChemDiv3_003976 Fc1ccc(Nc2nc3ccccc3nc2Nc4ccc(F)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E17 compound treatment 173520.0 13700.0 0.53 245840.0 68000.0 2.55 2.1812 0.8362 1173393 ChemDiv3_003977 CC(C)N(C(=O)Cn1c2ccccc2c3nc4ccccc4nc13)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E18 compound treatment 185640.0 25800.0 1.0 188000.0 10200.0 0.38 0.9787 0.9132 3023963 ChemDiv3_003978 OC(C#CCN1CCOCC1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E19 compound treatment 180520.0 20700.0 0.8 228520.0 50700.0 1.9 1.9136 0.9262 3119252 ChemDiv3_003979 CCN(CC)C(=S)SC1=CCS(=O)(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E20 compound treatment 133520.0 -26300.0 -1.02 124320.0 -53500.0 -2.01 -2.1412 -0.9509 1158512 ChemDiv3_003980 COc1ccc2c(c1)c(=O)oc3cc(OC(C)C)ccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E21 compound treatment 180480.0 20600.0 0.8 184600.0 6810.0 0.26 0.7469 0.8886 3119253 ChemDiv3_003981 CC12CS(=O)(=O)CC2SC(=S)N1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E22 compound treatment 170600.0 10800.0 0.42 191520.0 13700.0 0.52 0.6595 0.9945 1357925 ChemDiv3_003982 CN(C)C(=O)COc1cc(C)cc2oc(=O)c3CCCCc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E23 mock treatment 177880.0 18000.0 0.7 192720.0 14900.0 0.56 0.8911 0.9939 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 E24 mock treatment 153440.0 -6400.0 -0.25 168600.0 -9190.0 -0.34 -0.4196 -0.987 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F01 compound treatment 180480.0 20600.0 0.8 179560.0 1770.0 0.07 0.6132 0.7631 3023964 ChemDiv3_003983 CN1C(=O)/C(=C/c2ccc(o2)c3ccc(Cl)cc3)/C(=C(C#N)C1=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F02 compound treatment 170080.0 10200.0 0.4 196240.0 18400.0 0.69 0.7705 0.9652 3119382 ChemDiv3_003984 O=C(NC1=NCCS1)c2cc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F03 compound treatment 155120.0 -4720.0 -0.18 152040.0 -25800.0 -0.97 -0.8129 -0.8264 1627858 ChemDiv3_003985 CN(C)c1ccc2nc3C(=O)c4ccccc4C(=O)c3nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F04 compound treatment 165640.0 5800.0 0.22 187640.0 9850.0 0.37 0.4205 0.9717 3119383 ChemDiv3_003986 CC1=[N+]([O-])C(C)(C)[N+](=C1c2ccc(C)cc2)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F05 compound treatment 168040.0 8200.0 0.32 193440.0 15600.0 0.59 0.6402 0.9585 3119384 ChemDiv3_003987 COC(=O)c1ccc(NC(=O)CC2Sc3ccc(cc3NC2=O)C(F)(F)F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F06 compound treatment 167080.0 7240.0 0.28 184920.0 7130.0 0.27 0.3878 0.9997 3023965 ChemDiv3_003988 CC(C)Cc1c(O)nc(SCC(=O)NC(C)(C)C)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F07 compound treatment 14280.0 -146000.0 -5.65 139840.0 -38000.0 -1.42 -5.0008 -0.8586 3119385 ChemDiv3_003989 Cc1ccccc1OCC(=O)Nc2cccc(c2)c3nnc(o3)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F08 compound treatment 187800.0 28000.0 1.08 209640.0 31800.0 1.2 1.6123 0.9988 3023966 ChemDiv3_003990 COC(=O)c1c(C)c(=O)[nH]c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F09 compound treatment 144040.0 -15800.0 -0.61 236880.0 59100.0 2.22 1.1346 0.4931 1509397 ChemDiv3_003991 Fc1ccc(cc1)C(=O)Nc2ncnc3sc4CCCCCc4c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F10 compound treatment 170280.0 10400.0 0.41 185600.0 7810.0 0.29 0.4936 0.9874 3023967 ChemDiv3_003992 FC(F)(F)C1(N=C(OC(=N1)c2ccccc2)N3CCCCC3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F11 compound treatment 189280.0 29400.0 1.14 184680.0 6890.0 0.26 0.9905 0.8458 1229183 ChemDiv3_003993 Cc1sc2nc3c4ccccc4c(NCCO)nn3c(=O)c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F12 compound treatment 204720.0 44900.0 1.74 225280.0 47500.0 1.78 2.4916 0.9999 1299234 ChemDiv3_003994 COC(=O)c1c(N)n(CCc2ccccc2)c3nc4ccccc4nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F13 compound treatment 197320.0 37500.0 1.45 198440.0 20600.0 0.77 1.5763 0.9566 1319064 ChemDiv3_003995 Cc1ccc(Oc2nnc(c3cccs3)c4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F14 compound treatment 189080.0 29200.0 1.13 219560.0 41800.0 1.57 1.9107 0.9874 3119386 ChemDiv3_003996 Cc1cccc(N/C=C\2/C(=O)N(C(=O)c3ccccc23)c4ccccc4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F15 compound treatment 190640.0 30800.0 1.19 184840.0 7050.0 0.26 1.0321 0.8432 3023968 ChemDiv3_003997 Cn1nc(CC(=O)Nc2nc(cs2)c3ccccc3)c4ccccc4c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F16 compound treatment 65160.0 -94700.0 -3.67 161200.0 -16600.0 -0.62 -3.038 -0.8153 3119387 ChemDiv3_003998 COc1ccc(/N=C/c2c(O)ccc3oc4CCCCc4c23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F17 compound treatment 211600.0 51800.0 2.01 210840.0 33000.0 1.24 2.2971 0.9732 1229320 ChemDiv3_003999 CCOC(=O)CN1C(=O)C2(C(=C(N)OC3=C2C(=O)CC(C)(C)C3)C(=O)OCC)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F18 compound treatment 150720.0 -9120.0 -0.35 166520.0 -11300.0 -0.42 -0.5494 -0.9961 1796400 ChemDiv3_004000 COc1ccc(CCn2cnc3sc4CCCCc4c3c2=N)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F19 compound treatment 112120.0 -47700.0 -1.85 148480.0 -29300.0 -1.1 -2.0872 -0.9691 1598055 ChemDiv3_004001 Cc1cc(C(=O)CSc2nnc3cc(C)c4ccccc4n23)c(C)n1Cc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F20 compound treatment 177640.0 17800.0 0.69 226200.0 48400.0 1.82 1.773 0.9122 3024019 ChemDiv3_004002 CC(=O)N1C(=N)S/C(=C/c2cc3ccc(C)cc3nc2O)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F21 compound treatment 186880.0 27000.0 1.05 186840.0 9050.0 0.34 0.982 0.8905 1409929 ChemDiv3_004003 Cn1nc(C(=O)O)c2ccccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F22 compound treatment 174920.0 15100.0 0.59 172440.0 -5350.0 -0.2 0.2717 0.4392 1387840 ChemDiv3_004004 CCOC(=O)Cc1c(C)nc(Cc2ccc(OC(C)C)cc2)nc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F23 mock treatment 162920.0 3080.0 0.12 192040.0 14200.0 0.53 0.4626 0.8442 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 F24 mock treatment 143800.0 -16000.0 -0.62 187280.0 9490.0 0.36 -0.1883 -0.2626 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G01 compound treatment 123800.0 -36000.0 -1.4 145480.0 -32300.0 -1.21 -1.8463 -0.9975 3119388 ChemDiv3_004005 COC(=O)C1=CN(C=C(C1c2ccccc2)C(=O)OC)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G02 compound treatment 23640.0 -136000.0 -5.28 32040.0 -146000.0 -5.47 -7.6049 -0.9999 3024021 ChemDiv3_004006 Cc1cc(/C=C/2\C(=O)NC(=S)N(CC=C)C2=O)c(C)n1c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G03 compound treatment 141600.0 -18200.0 -0.71 157800.0 -20000.0 -0.75 -1.031 -0.9996 3119389 ChemDiv3_004007 c1ccc2sc(nc2c1)c3cccc(n3)c4nc5ccccc5s4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G04 compound treatment 145000.0 -14800.0 -0.58 197880.0 20100.0 0.75 0.126 0.1328 3119390 ChemDiv3_004008 COc1ccc(Cc2nnc(SCC(=O)Nc3ccc(OC)cc3)o2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G05 compound treatment 131400.0 -28400.0 -1.1 132840.0 -45000.0 -1.69 -1.9733 -0.9788 3024022 ChemDiv3_004009 COc1ccc(/C=C/C=N/n2c(SC)nnc2c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G06 compound treatment 135320.0 -24500.0 -0.95 155400.0 -22400.0 -0.84 -1.267 -0.9981 1871125 ChemDiv3_004010 Cc1c(C)c2ccccc2n1C(=O)CSc3nc4ccccc4s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G07 compound treatment 156480.0 -3360.0 -0.13 167880.0 -9910.0 -0.37 -0.3553 -0.9012 1673764 ChemDiv3_004011 CC(=O)N1C(Oc2nc(SCC=C)nnc2-c3ccccc13)c4ccc(o4)c5ccc(F)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G08 compound treatment 144560.0 -15300.0 -0.59 152800.0 -25000.0 -0.94 -1.0825 -0.9755 3119391 ChemDiv3_004012 COc1ccc(NC(=O)C2CC(=O)N=C(Nc3ccccc3)S2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G09 compound treatment 151640.0 -8200.0 -0.32 163160.0 -14600.0 -0.55 -0.6133 -0.9663 1613829 ChemDiv3_004013 CCSc1nnc(c(O)n1)c2ccccc2NC(=O)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G10 compound treatment 128320.0 -31500.0 -1.22 135240.0 -42600.0 -1.6 -1.9941 -0.9913 1558726 ChemDiv3_004014 CC(C)(C)NC(=O)N1c2ccccc2Sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G11 compound treatment 157000.0 -2840.0 -0.11 182920.0 5130.0 0.19 0.0582 0.2622 3119392 ChemDiv3_004015 Cc1nn(C)c(C)c1NC(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G12 compound treatment 132680.0 -27200.0 -1.05 138280.0 -39500.0 -1.48 -1.7938 -0.986 1465103 ChemDiv3_004016 CCc1ccc(CN2CCN(Cc3cccc(OC)c3)CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G13 compound treatment 162720.0 2880.0 0.11 178480.0 689.0 0.03 0.0973 0.8483 3119393 ChemDiv3_004017 CCNS(=O)(=O)c1cc(ccc1C)c2nnc(Nc3ccc(F)cc3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G14 compound treatment 184320.0 24500.0 0.95 182760.0 4970.0 0.19 0.8035 0.8301 1303056 ChemDiv3_004018 CC(C)(C)NC1=C(N(CC(=O)c2ccccc2)S(=O)(=O)c3ccccc13)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G15 compound treatment 161640.0 1800.0 0.07 183440.0 5650.0 0.21 0.1993 0.8928 1692964 ChemDiv3_004019 CCC(=O)N1N=C(CC1c2cc3cc(OC)ccc3nc2Cl)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G16 compound treatment 158680.0 -1160.0 -0.05 171720.0 -6070.0 -0.23 -0.193 -0.8308 1699942 ChemDiv3_004020 Brc1ccc(cc1)C2NC(=O)c3ccccc3O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G17 compound treatment 145680.0 -14200.0 -0.55 196800.0 19000.0 0.71 0.1159 0.1288 3024023 ChemDiv3_004021 CC(=O)OC1CCS(=O)(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G18 compound treatment 18520.0 -141000.0 -5.48 55240.0 -123000.0 -4.6 -7.1297 -0.9962 3119394 ChemDiv3_004022 CCCc1n[nH]c2OC(=C(C#N)C(CCc3ccccc3)c12)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G19 compound treatment 156040.0 -3800.0 -0.15 182400.0 4610.0 0.17 0.018 0.0793 3024024 ChemDiv3_004023 CC1(CCS(=O)(=O)C1)NC(=S)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G20 compound treatment 169680.0 9840.0 0.38 205520.0 27700.0 1.04 1.0058 0.9074 1713974 ChemDiv3_004024 Oc1cc(OCC(=O)c2ccccc2)cc3oc(cc(=O)c13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G21 compound treatment 158680.0 -1160.0 -0.05 194200.0 16400.0 0.62 0.4036 0.6536 1338699 ChemDiv3_004025 CCCCN(C1CCS(=O)(=O)C1)C(=O)Nc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G22 compound treatment 155000.0 -4840.0 -0.19 164080.0 -13700.0 -0.51 -0.4967 -0.9067 1306939 ChemDiv3_004026 Cc1c(OC(=O)c2ccco2)ccc3c4CCCc4c(=O)oc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G23 mock treatment 179000.0 19200.0 0.74 177720.0 -71.3 0.0 0.5237 0.7046 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 G24 mock treatment 129960.0 -29900.0 -1.16 176280.0 -1510.0 -0.06 -0.8599 -0.7408 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H01 compound treatment 82480.0 -77400.0 -3.0 99000.0 -78800.0 -2.96 -4.2135 -1.0 3119395 ChemDiv3_004027 CC(C)N1C(=O)S/C(=C/c2ccc(Sc3nc4ccccc4[nH]3)o2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H02 compound treatment 165400.0 5560.0 0.22 189800.0 12000.0 0.45 0.4712 0.9431 3024025 ChemDiv3_004028 Cc1c(c2ccco2)[n+]([O-])c(c(C)[n+]1[O-])c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H03 compound treatment 11600.0 -148000.0 -5.75 13280.0 -165000.0 -6.17 -8.4331 -0.9994 3119396 ChemDiv3_004029 C/C(=N\O)/CCc1oc2ccccc2c1c3ccc(C)o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H04 compound treatment 149640.0 -10200.0 -0.4 177920.0 129.0 0.0 -0.2765 -0.6984 3024026 ChemDiv3_004030 CC1N(O)C(C)(C)[N+](=C1c2ccccc2)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H05 compound treatment 157120.0 -2720.0 -0.11 158640.0 -19200.0 -0.72 -0.5829 -0.8024 3024027 ChemDiv3_004031 CC(=O)N/C(=C\c1cccs1)/C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H06 compound treatment 167200.0 7360.0 0.29 163640.0 -14200.0 -0.53 -0.1737 -0.288 3119397 ChemDiv3_004032 CCSc1nc(O)c(C(C)CC)c(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H07 compound treatment 128520.0 -31300.0 -1.22 145560.0 -32200.0 -1.21 -1.7147 -1.0 1130593 ChemDiv3_004033 O=C(Cc1ccccc1)Nc2cccc(c2)S(=O)(=O)c3cccc(NC(=O)Cc4ccccc4)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H08 compound treatment 175560.0 15700.0 0.61 179920.0 2130.0 0.08 0.4878 0.793 3024028 ChemDiv3_004034 CCOC(=O)c1nn(c(C#N)c1NC(=O)c2nn(CC)cc2Br)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H09 compound treatment 15200.0 -145000.0 -5.61 43440.0 -134000.0 -5.04 -7.5339 -0.9986 1423488 ChemDiv3_004035 COc1cc2c(cc1NP(=O)(C)Oc3ccccc3)oc4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H10 compound treatment 176200.0 16400.0 0.63 200600.0 22800.0 0.86 1.0541 0.9892 3024029 ChemDiv3_004036 COc1ccc(Cl)cc1NC2=NCC(C)S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H11 compound treatment 174080.0 14200.0 0.55 189080.0 11300.0 0.42 0.6902 0.9914 1247540 ChemDiv3_004037 CC1CCN(CC1)c2nn3c(=O)c4c(C)c(C)sc4nc3c5ccccc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H12 compound treatment 202240.0 42400.0 1.65 198960.0 21200.0 0.79 1.725 0.9443 1685422 ChemDiv3_004038 CCOC(=O)c1c(N)n(C2CCCCC2)c3nc4ccccc4nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H13 compound treatment 137120.0 -22700.0 -0.88 135320.0 -42500.0 -1.59 -1.7505 -0.961 1241398 ChemDiv3_004039 C1CCCN(CC1)c2nnc(c3cccs3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H14 compound treatment 171520.0 11700.0 0.45 203120.0 25300.0 0.95 0.9926 0.9426 3119548 ChemDiv3_004040 CCc1ccc(N/C=C\2/C(=O)N(C(=O)c3ccccc23)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H15 compound treatment 165560.0 5720.0 0.22 171880.0 -5910.0 -0.22 0.0 1.0E-4 3024030 ChemDiv3_004041 O=C(Oc1ccc(cc1)N(Cc2cccs2)C3=NS(=O)(=O)c4ccccc34)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H16 compound treatment 162200.0 2360.0 0.09 165240.0 -12600.0 -0.47 -0.2684 -0.5593 3119549 ChemDiv3_004042 Oc1ccc2oc3CCCCc3c2c1/C=N/N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H17 compound treatment 154640.0 -5200.0 -0.2 160680.0 -17100.0 -0.64 -0.5968 -0.8866 1705908 ChemDiv3_004043 CCOC(=O)CN1C(=O)C2(C(=C(N)Oc3[nH]nc(C)c32)C#N)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H18 compound treatment 25960.0 -134000.0 -5.19 73640.0 -104000.0 -3.91 -6.4372 -0.9902 3024031 ChemDiv3_004044 COc1ccc(CCn2cnc3oc(c(c4ccccc4)c3c2=N)c5ccccc5)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H19 compound treatment 168960.0 9120.0 0.35 184440.0 6650.0 0.25 0.4266 0.9854 3119550 ChemDiv3_004045 Cc1nc(SC2CCCCN(C(=O)c3ccc(Cl)cc3)C2=O)c4c5CCCCc5sc4n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H20 compound treatment 162440.0 2600.0 0.1 173800.0 -3990.0 -0.15 -0.0346 -0.1918 3442340 ChemDiv3_004046 CC(C)CC(Nc1ncnc2sc3CCCc3c12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H21 compound treatment 178920.0 19100.0 0.74 172320.0 -5470.0 -0.21 0.3782 0.4924 3024084 ChemDiv3_004047 COC(=O)/C=c/1\sc2ncnn2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H22 compound treatment 154600.0 -5240.0 -0.2 163440.0 -14400.0 -0.54 -0.5247 -0.9113 1470170 ChemDiv3_004048 Nc1cc(=O)nc(SCC(=O)NCc2ccccc2)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H23 mock treatment 157440.0 -2400.0 -0.09 188360.0 10600.0 0.4 0.2146 0.5267 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 H24 mock treatment 126520.0 -33300.0 -1.29 173800.0 -3990.0 -0.15 -1.0201 -0.7838 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I01 compound treatment 134600.0 -25200.0 -0.98 160400.0 -17400.0 -0.65 -1.1541 -0.9806 3024085 ChemDiv3_004049 Cc1[n+](CC=C)n(C)c2cc(Cl)c(Cl)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I02 compound treatment 143400.0 -16400.0 -0.64 171960.0 -5830.0 -0.22 -0.6058 -0.8983 3119551 ChemDiv3_004050 COCCn1c(C)cc(/C=C/2\C(=O)NC(=S)N(CC=C)C2=O)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I03 compound treatment 162720.0 2880.0 0.11 175040.0 -2750.0 -0.1 0.006 0.0392 1185967 ChemDiv3_004051 CCSc1nnc-2c(OC(Nc3ccccc32)c4cc5OCOc5cc4Cl)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I04 compound treatment 117560.0 -42300.0 -1.64 139120.0 -38700.0 -1.45 -2.1863 -0.9981 3119552 ChemDiv3_004052 COc1ccc(Cl)c(NC2=NC(=O)/C(=C\c3cccnc3)/S2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I05 compound treatment 174440.0 14600.0 0.57 152200.0 -25600.0 -0.96 -0.2786 -0.2499 1528287 ChemDiv3_004053 CSc1nnc-2c(OC(C)N(C(=O)C)c3ccccc32)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I06 compound treatment 134120.0 -25700.0 -1.0 136400.0 -41400.0 -1.55 -1.8042 -0.9771 1788578 ChemDiv3_004054 O=C(CSc1nnc(o1)c2ccccc2)N3c4ccccc4CCc5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I07 compound treatment 155080.0 -4760.0 -0.18 151880.0 -25900.0 -0.97 -0.8183 -0.8266 3024086 ChemDiv3_004055 COC(=O)C1=C(C)NC(=S)NC1c2cc3OCOc3cc2Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I08 compound treatment 15080.0 -145000.0 -5.62 16080.0 -162000.0 -6.07 -8.2633 -0.9993 3119553 ChemDiv3_004056 FC(F)(F)c1cccc(c1)n2c(=O)oc3ccc(Cl)cc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I09 compound treatment 160320.0 479.0 0.02 169800.0 -7990.0 -0.3 -0.1989 -0.662 3119554 ChemDiv3_004057 CCc1ccc2NC(=O)/C(=C/3\S\C(=N/c4cccc(Cl)c4C)\NC3=O)/c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I10 compound treatment 123080.0 -36800.0 -1.43 142560.0 -35200.0 -1.32 -1.9436 -0.9993 1437793 ChemDiv3_004058 O=C(NCCc1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I11 compound treatment 163320.0 3480.0 0.13 193120.0 15300.0 0.58 0.5023 0.8499 3119555 ChemDiv3_004059 COC(=O)c1cc2c(C)nn(c3ccccc3)c2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I12 compound treatment 133920.0 -25900.0 -1.01 130480.0 -47300.0 -1.78 -1.9668 -0.9638 1679546 ChemDiv3_004060 CCc1ccc(CN2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I13 compound treatment 192800.0 33000.0 1.28 180760.0 2970.0 0.11 0.983 0.7658 3119556 ChemDiv3_004061 CCNS(=O)(=O)c1cc(ccc1C)c2nnc(OC)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I14 compound treatment 163040.0 3200.0 0.12 183520.0 5730.0 0.22 0.2398 0.9659 3024087 ChemDiv3_004062 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I15 compound treatment 163520.0 3680.0 0.14 175360.0 -2430.0 -0.09 0.0364 0.2149 1737307 ChemDiv3_004063 O=C(N1N=C(CC1c2ccc3nccnc3c2)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I16 compound treatment 162920.0 3080.0 0.12 160360.0 -17400.0 -0.65 -0.3781 -0.5686 3024088 ChemDiv3_004064 NC(=N)SCC1CN=C(S1)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I17 compound treatment 168920.0 9080.0 0.35 196080.0 18300.0 0.69 0.7344 0.9519 1449842 ChemDiv3_004065 CNC(=S)NC1CCS(=O)(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I18 compound treatment 172960.0 13100.0 0.51 164400.0 -13400.0 -0.5 0.0045 0.0063 3119557 ChemDiv3_004066 CCCOc1ccc(cc1OCC)C2C3=C(CCCC3=O)OC4=C2C(=O)CCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I19 compound treatment 158880.0 -961.0 -0.04 214200.0 36400.0 1.37 0.9399 0.6876 3024089 ChemDiv3_004067 CCCC(NC1CCS(=O)(=O)C1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I20 compound treatment 119320.0 -40500.0 -1.57 146680.0 -31100.0 -1.17 -1.9374 -0.9893 1874878 ChemDiv3_004068 COc1ccc2c(c1)c(=O)oc3c(C)c(OC(C(=O)O)c4ccccc4)ccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I21 compound treatment 154400.0 -5440.0 -0.21 179440.0 1650.0 0.06 -0.1055 -0.4797 1557945 ChemDiv3_004069 CCc1ccccc1NC(=O)CC2CS(=O)(=O)CC2CC(=O)Nc3ccccc3CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I22 compound treatment 143360.0 -16500.0 -0.64 152600.0 -25200.0 -0.95 -1.1207 -0.9819 3024090 ChemDiv3_004070 Cc1cc(OC(=O)c2cccs2)c3c4CCCc4c(=O)oc3c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I23 mock treatment 189040.0 29200.0 1.13 158840.0 -19000.0 -0.71 0.2981 0.2229 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 I24 mock treatment 134080.0 -25800.0 -1.0 179200.0 1410.0 0.05 -0.6694 -0.6688 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J01 compound treatment 21800.0 -138000.0 -5.36 28440.0 -149000.0 -5.61 -7.7509 -0.9997 3024091 ChemDiv3_004071 CC(C)N1C(=O)S/C(=C/c2cc(C)n(c2C)c3ccncc3)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J02 compound treatment 177680.0 17800.0 0.69 202960.0 25200.0 0.94 1.1574 0.9883 3119558 ChemDiv3_004072 CC(=O)OC1CCC(OC(=O)C)c2c1[n+]([O-])c(C)c(C)[n+]2[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J03 compound treatment 124640.0 -35200.0 -1.37 152840.0 -25000.0 -0.94 -1.628 -0.9831 3024092 ChemDiv3_004073 S=c1cc(oc(c1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J04 compound treatment 171000.0 11200.0 0.43 176840.0 -951.0 -0.04 0.2809 0.6466 3119559 ChemDiv3_004074 Cc1c(c2ccccc2)[n+]([O-])c(c(C)[n+]1[O-])c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J05 compound treatment 63080.0 -96800.0 -3.75 70400.0 -107000.0 -4.03 -5.5048 -0.9994 1128591 ChemDiv3_004075 COc1ccc(CC(=O)Nc2cccc(c2)c3nc4cc5ccccc5cc4[nH]3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J06 compound treatment 178520.0 18700.0 0.72 159240.0 -18600.0 -0.7 0.0201 0.02 1255030 ChemDiv3_004076 COc1ccc(cc1OC)C2C(c3cc(OC)c(OC)cc3C2=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J07 compound treatment 188880.0 29000.0 1.13 151880.0 -25900.0 -0.97 0.109 0.0733 3119560 ChemDiv3_004077 O=C(Nc1cccc(c1)c2nc3ccccc3c(=O)o2)C4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J08 compound treatment 170560.0 10700.0 0.42 242680.0 64900.0 2.44 2.0162 0.816 3024093 ChemDiv3_004078 CCOC(=O)c1nn(c(C(=O)OCC)c1NC(=O)C2CCCCC2)c3ccc(OC)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J09 compound treatment 214040.0 54200.0 2.1 164320.0 -13500.0 -0.51 1.1295 0.5222 1215988 ChemDiv3_004079 OC(=O)c1c2CC(CCc2nc3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J10 compound treatment 29840.0 -130000.0 -5.04 52440.0 -125000.0 -4.7 -6.8934 -0.9994 3119561 ChemDiv3_004080 CC1CN=C(S1)N(C(=O)Nc2ccccc2)c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J11 compound treatment 187280.0 27400.0 1.06 217600.0 39800.0 1.49 1.8093 0.9862 1549011 ChemDiv3_004081 Cc1ccc(cc1)c2nn3c(=O)c4ccccc4nc3c5ccccc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J12 compound treatment 193640.0 33800.0 1.31 206360.0 28600.0 1.07 1.6855 0.995 1317257 ChemDiv3_004082 CCc1ccc(cc1)n2c(N)c(C(=O)OC)c3nc4ccccc4nc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J13 compound treatment 169680.0 9840.0 0.38 181960.0 4170.0 0.16 0.3806 0.9224 3024094 ChemDiv3_004083 O=C(CSc1ncnc2sc(cc12)c3ccccc3)c4ccc5OCCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J14 compound treatment 75880.0 -84000.0 -3.26 150360.0 -27400.0 -1.03 -3.0316 -0.8873 3119562 ChemDiv3_004084 FC(F)(F)c1cccc(N/C=C\2/C(=O)N(C(=O)c3ccccc23)c4ccccc4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J15 compound treatment 156720.0 -3120.0 -0.12 159080.0 -18700.0 -0.7 -0.5822 -0.817 1305983 ChemDiv3_004085 CCCN1CC=C2C(C1)C3(C(=O)Nc4ccccc43)C(C#N)(C#N)C(=C2C#N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J16 compound treatment 173200.0 13400.0 0.52 173560.0 -4230.0 -0.16 0.2542 0.4689 1458619 ChemDiv3_004086 CC(C)(C)c1nc2scc(c3ccccc3)c2c(=O)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J17 compound treatment 151280.0 -8560.0 -0.33 173200.0 -4590.0 -0.17 -0.3567 -0.9533 1274153 ChemDiv3_004087 CCOC(=O)C1=C(N)Oc2c(c(=O)oc3ccccc23)C41C(=O)N(CC(=O)OC)c5ccccc54 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J18 compound treatment 86040.0 -73800.0 -2.86 149640.0 -28200.0 -1.06 -2.7719 -0.9082 1393431 ChemDiv3_004088 CCn1c(=O)c2c(-c3ccccc3CC42CCCCC4)n5c(SCC(=O)N)nnc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J19 compound treatment 11880.0 -148000.0 -5.74 15840.0 -162000.0 -6.08 -8.3575 -0.9996 3119696 ChemDiv3_004089 CCN(CC)C(=O)O[n+]1cccc(CC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J20 compound treatment 22720.0 -137000.0 -5.32 39000.0 -139000.0 -5.21 -7.4454 -0.9999 3119697 ChemDiv3_004090 C=CCN1C(=C(OC(=O)c2ccccc2)c3ccccc3S1(=O)=O)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J21 compound treatment 163080.0 3240.0 0.13 206600.0 28800.0 1.08 0.8534 0.784 1423420 ChemDiv3_004091 Cc1cc(C)n(n1)c2nnc(C)n2NC(=S)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J22 compound treatment 156880.0 -2960.0 -0.11 171840.0 -5950.0 -0.22 -0.2392 -0.9522 3119698 ChemDiv3_004092 COC(=O)/C=C/1\N(C(=NC1=O)Nc2nc(C)cc(C)n2)c3cccc(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J23 mock treatment 161480.0 1640.0 0.06 182160.0 4370.0 0.16 0.1609 0.9149 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 J24 mock treatment 147800.0 -12000.0 -0.47 200560.0 22800.0 0.85 0.2739 0.2812 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K01 compound treatment 131000.0 -28800.0 -1.12 178640.0 849.0 0.03 -0.7688 -0.6867 3023297 ChemDiv3_004093 Oc1cc(C2C(=O)c3ccccc3C2=O)c4ccc5ccccc5c4n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K02 compound treatment 130800.0 -29000.0 -1.13 157440.0 -20400.0 -0.76 -1.3369 -0.9821 3119699 ChemDiv3_004094 COCCn1c(C)cc(C=C2C(=O)N(C)C(=S)N(C)C2=O)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K03 compound treatment 145000.0 -14800.0 -0.58 160480.0 -17300.0 -0.65 -0.8666 -0.9982 1169810 ChemDiv3_004095 CSc1nnc-2c(OC(Nc3ccccc32)c4ccccc4)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K04 compound treatment 164840.0 5000.0 0.19 171560.0 -6230.0 -0.23 -0.0282 -0.0929 3119700 ChemDiv3_004096 OC(=O)c1ccc(cc1)c2ccc(/C=C\3/SC(=NC3=O)Nc4cccc(c4)C(=O)O)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K05 compound treatment 107280.0 -52600.0 -2.04 114080.0 -63700.0 -2.39 -3.1329 -0.9969 3119701 ChemDiv3_004097 CC/1=NN(C(=O)\C1=C/Nc2cc(C)ccn2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K06 compound treatment 157920.0 -1920.0 -0.07 199040.0 21200.0 0.8 0.5112 0.6382 1871177 ChemDiv3_004098 COc1ccc(Nc2nc(N)nc(CN3CCCCC3)n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K07 compound treatment 142600.0 -17200.0 -0.67 143120.0 -34700.0 -1.3 -1.3932 -0.9522 3119702 ChemDiv3_004099 CN/1C(=N)NC(=O)\C1=C\c2ccc(C)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K08 compound treatment 155840.0 -4000.0 -0.16 172760.0 -5030.0 -0.19 -0.2433 -0.9953 3023298 ChemDiv3_004100 COc1ccc(C=C2C(=O)OC3(CCCCC3)OC2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K09 compound treatment 142360.0 -17500.0 -0.68 175440.0 -2350.0 -0.09 -0.542 -0.7924 3119703 ChemDiv3_004101 CCOc1cc(/C=C/2\C(=O)Nc3ccc(Br)cc23)ccc1OCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K10 compound treatment 114120.0 -45700.0 -1.77 134160.0 -43600.0 -1.64 -2.4123 -0.9992 1400389 ChemDiv3_004102 CCOC(=O)C1CCN(CC1)C(=O)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K11 compound treatment 145320.0 -14500.0 -0.56 156160.0 -21600.0 -0.81 -0.9725 -0.9841 1679244 ChemDiv3_004103 Cc1ccc(Nc2nc(C)cc(C)c2C(=O)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K12 compound treatment 166080.0 6240.0 0.24 182360.0 4570.0 0.17 0.2924 0.9857 1721188 ChemDiv3_004104 CCCS(=O)(=O)N1CCN(CC1)C2CCN(CC2)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K13 compound treatment 115400.0 -44400.0 -1.72 120720.0 -57100.0 -2.14 -2.7339 -0.9942 1612458 ChemDiv3_004105 CCn1c2ccccc2c3cc(NS(=O)(=O)c4ccccc4)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K14 compound treatment 158960.0 -881.0 -0.03 189280.0 11500.0 0.43 0.2807 0.649 1300482 ChemDiv3_004106 CN1C(=C(N2CCOCC2)c3ccccc3S1(=O)=O)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K15 compound treatment 143080.0 -16800.0 -0.65 184480.0 6690.0 0.25 -0.2823 -0.405 3023329 ChemDiv3_004107 COc1ccc(cc1)C2=NN(C(C2)c3ccccc3OC)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K16 compound treatment 170640.0 10800.0 0.42 180880.0 3090.0 0.12 0.3782 0.8701 3119704 ChemDiv3_004108 NC1(N)OC(CN2C(=O)c3ccccc3C2=O)CS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K17 compound treatment 154640.0 -5200.0 -0.2 176280.0 -1510.0 -0.06 -0.1828 -0.8721 1697884 ChemDiv3_004109 CCOC(=O)NC1CS(=O)(=O)C=C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K18 compound treatment 178720.0 18900.0 0.73 161520.0 -16300.0 -0.61 0.0861 0.0903 3119705 ChemDiv3_004110 CCN1C2=C(C(C3=C1CC(C)(C)CC3=O)c4ccc(OC)cc4)C(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K19 compound treatment 164960.0 5120.0 0.2 187600.0 9810.0 0.37 0.4008 0.9581 1179086 ChemDiv3_004111 O=S1(=O)CCC(C1)NC(=S)N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K20 compound treatment 140200.0 -19600.0 -0.76 160480.0 -17300.0 -0.65 -0.9983 -0.9968 3119706 ChemDiv3_004112 CCCN1Cc2cccc(C(=O)N)c2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K21 compound treatment 146000.0 -13800.0 -0.54 181800.0 4010.0 0.15 -0.2734 -0.4901 1541504 ChemDiv3_004113 CC(C)NC(=S)SC1CS(=O)(=O)C=C1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K22 compound treatment 162520.0 2680.0 0.1 200320.0 22500.0 0.85 0.6714 0.7881 1280043 ChemDiv3_004114 Cc1cc(=O)oc2cc(OCc3cccc(F)c3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K23 mock treatment 164120.0 4280.0 0.17 155840.0 -22000.0 -0.82 -0.4652 -0.5535 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 K24 mock treatment 128200.0 -31600.0 -1.23 172400.0 -5390.0 -0.2 -1.0112 -0.8127 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L01 compound treatment 131760.0 -28100.0 -1.09 145320.0 -32500.0 -1.22 -1.6322 -0.9984 3119707 ChemDiv3_004115 COCCN1C(=O)N(C(=O)/C(=C\c2cn(CC(=O)OC)c3ccccc23)/C1=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L02 compound treatment 158600.0 -1240.0 -0.05 188040.0 10200.0 0.38 0.2379 0.6138 3023337 ChemDiv3_004116 CC1=[N+]([O-])C(C)(C)C(=[N+]1[O-])c2ccc(C)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L03 compound treatment 10960.0 -149000.0 -5.78 11560.0 -166000.0 -6.24 -8.4963 -0.9993 3119708 ChemDiv3_004117 CCOc1ccc(cc1c2nc(=O)c3n(C)nc(c3[nH]2)C(C)(C)C)S(=O)(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L04 compound treatment 152520.0 -7320.0 -0.28 154080.0 -23700.0 -0.89 -0.8301 -0.8886 3023341 ChemDiv3_004118 [O-][n+]1cc(c2ccccc2)[n+]([O-])c3CCCCc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L05 compound treatment 162800.0 2960.0 0.11 161200.0 -16600.0 -0.62 -0.3591 -0.5672 3023342 ChemDiv3_004119 CC(C)C(=O)Nc1cccc(c1)c2nc3ccccc3c(=O)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L06 compound treatment 131880.0 -28000.0 -1.08 174600.0 -3190.0 -0.12 -0.8518 -0.7804 3119709 ChemDiv3_004120 CCc1ccc(OCCCn2cc(/C=C\3/C(=N)N4C=CSC4=NC3=O)c5ccccc25)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L07 compound treatment 138520.0 -21300.0 -0.83 155880.0 -21900.0 -0.82 -1.1665 -1.0 3023344 ChemDiv3_004121 CCSc1ncnc2c3cc4COC(C)(C)Cc4nc3sc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L08 compound treatment 182000.0 22200.0 0.86 171360.0 -6430.0 -0.24 0.4373 0.4897 1713113 ChemDiv3_004122 O=S1(=O)C=C(SCCN2CCOCC2)c3ccccc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L09 compound treatment 154280.0 -5560.0 -0.22 183160.0 5370.0 0.2 -0.0101 -0.0342 3023346 ChemDiv3_004123 CN(C)c1oc(nc1C#N)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L10 compound treatment 138360.0 -21500.0 -0.83 137160.0 -40600.0 -1.52 -1.6677 -0.9596 3119710 ChemDiv3_004124 CCC1(COC(NC(=O)c2ccc(Cl)cc2Cl)(C(F)(F)F)C(F)(F)F)COC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L11 compound treatment 91040.0 -68800.0 -2.67 141000.0 -36800.0 -1.38 -2.864 -0.9529 1380020 ChemDiv3_004125 CCC1CCc2c(C1)sc3ncnc(N4CCOCC4)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L12 compound treatment 126520.0 -33300.0 -1.29 141320.0 -36500.0 -1.37 -1.8821 -0.9996 1709855 ChemDiv3_004126 CCOc1ccc(cc1)S(=O)(=O)Nc2nc3ccccc3nc2Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L13 compound treatment 141880.0 -18000.0 -0.7 170360.0 -7430.0 -0.28 -0.69 -0.9192 1688543 ChemDiv3_004127 Cc1cc(C)c(C)c(c1C)S(=O)(=O)N2CCN(CC2)c3ncnc4sc5CCCCc5c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L14 compound treatment 146080.0 -13800.0 -0.53 158400.0 -19400.0 -0.73 -0.8922 -0.9884 1554741 ChemDiv3_004128 COc1ccc2n(CCc3ccc(OC)c(OC)c3)c(C)c(C(=O)O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L15 compound treatment 149160.0 -10700.0 -0.41 165160.0 -12600.0 -0.47 -0.6283 -0.9978 1579821 ChemDiv3_004129 COC(=O)CC1=C(C(=O)OC)C2(C(=O)Nc3ccccc32)C(=C(N)O1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L16 compound treatment 12040.0 -148000.0 -5.73 14240.0 -164000.0 -6.14 -8.3955 -0.9994 3119711 ChemDiv3_004130 O/N=C/c1c(O)c(Br)cc2oc3CCCCc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L17 compound treatment 146280.0 -13600.0 -0.53 165760.0 -12000.0 -0.45 -0.6914 -0.9971 1421908 ChemDiv3_004131 O=c1n(CN2CCCCC2)nnc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L18 compound treatment 148240.0 -11600.0 -0.45 170400.0 -7390.0 -0.28 -0.5144 -0.973 1535030 ChemDiv3_004132 COc1ccc(cc1)C(=O)n2nc3CC(C)(C)OCc3c2c4ccc(OC)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L19 compound treatment 154760.0 -5080.0 -0.2 162640.0 -15200.0 -0.57 -0.5415 -0.8997 3119712 ChemDiv3_004133 Cc1ccc(cc1)S(=O)(=O)N/2C(=O)C(C)(C)S\C2=N/CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L20 compound treatment 168400.0 8560.0 0.33 163240.0 -14600.0 -0.55 -0.1514 -0.2368 1346941 ChemDiv3_004134 CN1CCN(Cc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L21 compound treatment 100040.0 -59800.0 -2.32 126800.0 -51000.0 -1.91 -2.994 -0.9954 3119713 ChemDiv3_004135 Cc1nnc(SCc2cccc(c2)C(=O)c3ccccc3)nc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L22 compound treatment 142080.0 -17800.0 -0.69 161920.0 -15900.0 -0.6 -0.9085 -0.9974 3119714 ChemDiv3_004136 CC1CCN(CC1)/C(=N\S(=O)(=O)c2ccc(Br)cc2)/Nc3nc(C)cc(C)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L23 mock treatment 165360.0 5520.0 0.21 183000.0 5210.0 0.2 0.2896 0.999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 L24 mock treatment 131960.0 -27900.0 -1.08 169120.0 -8670.0 -0.33 -0.9951 -0.8808 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M01 compound treatment 7440.0 -152000.0 -5.91 8800.0 -169000.0 -6.34 -8.6661 -0.9994 3119869 ChemDiv3_004137 CCc1cc(C)cc(OCCn2cc(C=C3C(=O)NC(=O)NC3=O)c4ccccc24)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M02 compound treatment 150040.0 -9800.0 -0.38 148880.0 -28900.0 -1.09 -1.0362 -0.9012 3023448 ChemDiv3_004138 CN1C(=O)C(=Cc2cn(CC=C)c3ccccc23)C(=O)N(C)C1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M03 compound treatment 158200.0 -1640.0 -0.06 153080.0 -24700.0 -0.93 -0.7008 -0.7539 3023450 ChemDiv3_004139 CCc1cccc2c1NC(=O)C32OCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M04 compound treatment 144760.0 -15100.0 -0.59 167320.0 -10500.0 -0.39 -0.6917 -0.9812 1912757 ChemDiv3_004140 Cc1cc2/C(=C/c3ccco3)/OC(=O)c2c(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M05 compound treatment 152040.0 -7800.0 -0.3 176840.0 -951.0 -0.04 -0.2393 -0.7851 3119870 ChemDiv3_004141 CCSC1=N/C(=C\c2ccc(cc2)C(=O)O)/C(=O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M06 compound treatment 133920.0 -25900.0 -1.01 177920.0 129.0 0.0 -0.7078 -0.7037 3023453 ChemDiv3_004142 O=C(COc1ccccc1)N2CCN=C2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M07 compound treatment 131160.0 -28700.0 -1.11 145400.0 -32400.0 -1.22 -1.6465 -0.999 1181595 ChemDiv3_004143 CCC(=O)N1C(Oc2nc(SC)nnc2-c3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M08 compound treatment 143400.0 -16400.0 -0.64 171360.0 -6430.0 -0.24 -0.6218 -0.9116 1618375 ChemDiv3_004144 S=C1NC(C2=C(N1)c3ccccc3CC2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M09 compound treatment 143720.0 -16100.0 -0.63 149240.0 -28600.0 -1.07 -1.2 -0.9671 3023457 ChemDiv3_004145 CCCCN1C(=O)/C(=C/2\S/C(=N\c3ccc(Cl)cc3)/N(C)C2=O)/c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M10 compound treatment 51000.0 -109000.0 -4.22 101160.0 -76600.0 -2.88 -5.0199 -0.9825 3119871 ChemDiv3_004146 O=C(NCCCc1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M11 compound treatment 98880.0 -61000.0 -2.37 114560.0 -63200.0 -2.37 -3.3506 -1.0 1406185 ChemDiv3_004147 Cc1cc(C)c2c(N=NN3CCCCCC3)n[nH]c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M12 compound treatment 151920.0 -7920.0 -0.31 160560.0 -17200.0 -0.65 -0.6746 -0.9422 3119872 ChemDiv3_004148 Cc1cc(Br)ccc1NCc2ccc3OCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M13 compound treatment 166560.0 6720.0 0.26 172800.0 -4990.0 -0.19 0.0519 0.1616 1438334 ChemDiv3_004149 Brc1ccc2oc(=O)c(cc2c1)C(=O)N3CCCc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M14 compound treatment 158320.0 -1520.0 -0.06 154440.0 -23400.0 -0.88 -0.6615 -0.753 3023462 ChemDiv3_004150 CN1C(=C(Nc2ccccc2C)c3ccccc3S1(=O)=O)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M15 compound treatment 145000.0 -14800.0 -0.58 170560.0 -7230.0 -0.27 -0.5991 -0.9411 1567678 ChemDiv3_004151 COc1ccc(cc1)C2=NN(C(C2)c3ccc(C)cc3)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M16 compound treatment 144520.0 -15300.0 -0.59 163960.0 -13800.0 -0.52 -0.7874 -0.9977 3023506 ChemDiv3_004152 OC(=O)CP(=S)(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M17 compound treatment 22240.0 -138000.0 -5.34 46880.0 -131000.0 -4.91 -7.2495 -0.9991 1339249 ChemDiv3_004153 CCSC(=S)NC1CCS(=O)(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M18 compound treatment 138440.0 -21400.0 -0.83 165200.0 -12600.0 -0.47 -0.9213 -0.9643 3119873 ChemDiv3_004154 CCN1C2=C(C(C3=C1CCCC3=O)c4cccc(O)c4)C(=O)CCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M19 compound treatment 180200.0 20400.0 0.79 154280.0 -23500.0 -0.88 -0.0654 -0.0552 1468946 ChemDiv3_004155 CN(C1CCS(=O)(=O)C1)C(=S)SC2CS(=O)(=O)C=C2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M20 compound treatment 146080.0 -13800.0 -0.53 192240.0 14400.0 0.54 0.0059 0.0078 1541732 ChemDiv3_004156 COC(=O)c1ccc(COc2ccc3c(cc(=O)oc3c2C)c4ccccc4)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M21 compound treatment 146760.0 -13100.0 -0.51 164640.0 -13200.0 -0.49 -0.7079 -0.9999 1306134 ChemDiv3_004157 CN(C1CCCCC1)S(=O)(=O)C2CCS(=O)(=O)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M22 compound treatment 147080.0 -12800.0 -0.5 168160.0 -9630.0 -0.36 -0.6057 -0.988 3119874 ChemDiv3_004158 CC1CN(CC(C)O1)C2=NC(=O)/C(=C/c3ccccc3)/S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M23 mock treatment 152520.0 -7320.0 -0.28 168280.0 -9510.0 -0.36 -0.4533 -0.9936 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 M24 mock treatment 146040.0 -13800.0 -0.54 172680.0 -5110.0 -0.19 -0.5143 -0.9042 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N01 compound treatment 85040.0 -74800.0 -2.9 94400.0 -83400.0 -3.13 -4.2654 -0.9993 3023511 ChemDiv3_004159 O=C1S/C(=C\c2ccc(o2)N3CCOCC3)/C(=O)N1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N02 compound treatment 139280.0 -20600.0 -0.8 175520.0 -2270.0 -0.09 -0.6244 -0.7782 3119875 ChemDiv3_004160 CC1=[N+]([O-])C(C)(C)C(=[N+]1[O-])c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N03 compound treatment 70120.0 -89700.0 -3.48 58800.0 -119000.0 -4.47 -5.6195 -0.9924 3023512 ChemDiv3_004161 C1CCC2=C(C1)SC3=C(CCCC3)C2c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N04 compound treatment 97760.0 -62100.0 -2.41 116200.0 -61600.0 -2.31 -3.3378 -0.9998 1863423 ChemDiv3_004162 CSc1cccc(NC(=O)c2cc3c(ccc4ccccc34)o2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N05 compound treatment 56520.0 -103000.0 -4.01 70440.0 -107000.0 -4.03 -5.6837 -1.0 3023514 ChemDiv3_004163 O=C(ON1C(=O)c2ccccc2C1=O)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N06 compound treatment 135520.0 -24300.0 -0.94 167960.0 -9830.0 -0.37 -0.9282 -0.9161 1713635 ChemDiv3_004164 COC(=O)C1=C(C)Nc2c(C1c3cccc(OCc4ccccc4)c3)c(=O)n(C)c(=O)n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N07 compound treatment 140800.0 -19000.0 -0.74 148040.0 -29800.0 -1.12 -1.312 -0.9799 3023519 ChemDiv3_004165 CCCCS(=O)(=O)N=C1NCN(CCO)CN1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N08 compound treatment 133400.0 -26400.0 -1.03 157600.0 -20200.0 -0.76 -1.2613 -0.9889 3119876 ChemDiv3_004166 CC(C)(C)C1CCc2c(C1)sc3nc(oc(=O)c23)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N09 compound treatment 138240.0 -21600.0 -0.84 166760.0 -11000.0 -0.41 -0.8854 -0.9471 3119877 ChemDiv3_004167 CCOC(=O)c1c(NC(=O)CC2S/C(=N\CC)/N(CC)C2=O)sc3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N10 compound treatment 143480.0 -16400.0 -0.63 149400.0 -28400.0 -1.07 -1.2024 -0.9694 3023583 ChemDiv3_004168 COc1ccc(CNC(=N)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N11 compound treatment 11080.0 -149000.0 -5.77 12120.0 -166000.0 -6.22 -8.4781 -0.9993 1550858 ChemDiv3_004169 CC1CCN(CC1)c2nnc(c3cccs3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N12 compound treatment 153920.0 -5920.0 -0.23 160560.0 -17200.0 -0.65 -0.6198 -0.903 1484112 ChemDiv3_004170 O=S(=O)(Nc1nc2ccccc2nc1NCCC3=CCCCC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N13 compound treatment 162400.0 2560.0 0.1 166320.0 -11500.0 -0.43 -0.2342 -0.5301 1570344 ChemDiv3_004171 CCc1nc(n2nnc3cc(C)c(C)cc23)c4c5CCCCc5sc4n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N14 compound treatment 149400.0 -10400.0 -0.41 159040.0 -18800.0 -0.7 -0.7841 -0.9656 1352096 ChemDiv3_004172 CCOC(=O)c1c(C)n(C(C)C)c2ccc(OC(=O)c3ccccc3)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N15 compound treatment 149840.0 -10000.0 -0.39 151840.0 -26000.0 -0.97 -0.9631 -0.9186 1652261 ChemDiv3_004173 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C32C(=O)N(CO)c4ccccc43)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N16 compound treatment 10280.0 -150000.0 -5.8 12120.0 -166000.0 -6.22 -8.5001 -0.9994 3023589 ChemDiv3_004174 CC(C)(C)c1cc2oc3CCCCc3c2c(/C=N/Cc4ccncc4)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N17 compound treatment 110800.0 -49000.0 -1.9 127560.0 -50200.0 -1.89 -2.6786 -1.0 1176412 ChemDiv3_004175 Cc1onc(c1C(=O)NC(=S)NCc2ccco2)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N18 compound treatment 123920.0 -35900.0 -1.39 161760.0 -16000.0 -0.6 -1.411 -0.9295 1286690 ChemDiv3_004176 CC1(C)CC(CC(=O)N2CCOCC2)(CCO1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N19 compound treatment 11120.0 -149000.0 -5.77 12320.0 -165000.0 -6.21 -8.4717 -0.9993 1350975 ChemDiv3_004177 Cc1nn(C(=O)c2cccnc2)c(c1Sc3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N20 compound treatment 128560.0 -31300.0 -1.21 147120.0 -30700.0 -1.15 -1.6722 -0.9997 3119878 ChemDiv3_004178 CCCN(CCC)CN1CC(Cn2c3ccccc3c4ccccc24)OC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N21 compound treatment 122080.0 -37800.0 -1.47 133840.0 -44000.0 -1.65 -2.2024 -0.9983 1867988 ChemDiv3_004179 CC1CC(c2ccccc2)c3cc(C)ccc3N1S(=O)(=O)c4cccc(Cl)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N22 compound treatment 144040.0 -15800.0 -0.61 155440.0 -22400.0 -0.84 -1.0267 -0.9881 3119879 ChemDiv3_004180 Clc1ccc(cc1)C(=O)NC(=N)NCc2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N23 mock treatment 182720.0 22900.0 0.89 167200.0 -10600.0 -0.4 0.3466 0.3564 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 N24 mock treatment 139360.0 -20500.0 -0.79 164960.0 -12800.0 -0.48 -0.9025 -0.9712 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O01 compound treatment 172480.0 12600.0 0.49 177680.0 -111.0 0.0 0.3438 0.7011 3023594 ChemDiv3_004181 CSc1nnc(c(O)n1)c2ccccc2N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O02 compound treatment 171720.0 11900.0 0.46 157640.0 -20200.0 -0.76 -0.2089 -0.2359 3119880 ChemDiv3_004182 NC(=O)COc1ccc(C=C2C(=O)c3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O03 compound treatment 148840.0 -11000.0 -0.43 157400.0 -20400.0 -0.77 -0.843 -0.962 3023659 ChemDiv3_004183 CCc1ccc2NC(=O)/C(=C/3\NC(=S)NC3=O)/c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O04 compound treatment 157120.0 -2720.0 -0.11 183680.0 5890.0 0.22 0.0816 0.3332 1537162 ChemDiv3_004184 COCc1cc(C)nc2sc(C(=O)N)c(N)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O05 compound treatment 114640.0 -45200.0 -1.75 92160.0 -85600.0 -3.21 -3.5127 -0.9594 3023662 ChemDiv3_004185 COc1cccc(/C=C/2\N=C(SC)SC2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O06 compound treatment 152200.0 -7640.0 -0.3 173760.0 -4030.0 -0.15 -0.3166 -0.9512 3119881 ChemDiv3_004186 COc1cc(OC)cc(c1)C(=O)N2CCN=C2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O07 compound treatment 111800.0 -48000.0 -1.86 143360.0 -34400.0 -1.29 -2.2318 -0.984 3023663 ChemDiv3_004187 CCN(CC)c1ccc(/C=C/2\N(C)C(=N)NC2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O08 compound treatment 10040.0 -150000.0 -5.81 10800.0 -167000.0 -6.27 -8.5417 -0.9993 3119882 ChemDiv3_004188 CC(O)CN1C(=O)/C(=C/c2ccc(o2)c3ccc(Br)cc3)/C(=C(C#N)C1=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O09 compound treatment 104120.0 -55700.0 -2.16 69200.0 -109000.0 -4.08 -4.4107 -0.956 3023665 ChemDiv3_004189 CSC1=N/C(=C\c2ccc(Br)cc2)/C(=O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O10 compound treatment 159280.0 -561.0 -0.02 165120.0 -12700.0 -0.48 -0.3517 -0.7387 1520777 ChemDiv3_004190 CN1C(=O)C(C2CC1(C)Oc3ccccc23)C(=O)NC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O11 compound treatment 108040.0 -51800.0 -2.01 127120.0 -50700.0 -1.9 -2.766 -0.9996 1527053 ChemDiv3_004191 O=C(CN1CC(=O)Oc2ccccc12)OCC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O12 compound treatment 11720.0 -148000.0 -5.75 12160.0 -166000.0 -6.22 -8.4595 -0.9992 3120033 ChemDiv3_004192 CCn1c2ccccc2c3cc(CNCCc4ccc(Cl)cc4)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O13 compound treatment 156600.0 -3240.0 -0.13 172280.0 -5510.0 -0.21 -0.2352 -0.9715 1472912 ChemDiv3_004193 O=C(NC1(CCCCC1)C#N)c2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O14 compound treatment 155840.0 -4000.0 -0.16 157560.0 -20200.0 -0.76 -0.6467 -0.8344 3120034 ChemDiv3_004194 CCCN(CCC)C1=C(N(C)S(=O)(=O)c2ccccc12)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O15 compound treatment 159400.0 -441.0 -0.02 171880.0 -5910.0 -0.22 -0.169 -0.7594 3120035 ChemDiv3_004195 CS(=O)(=O)N1N=C(CC1c2cc3ccccc3nc2Cl)c4ccc(Br)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O16 compound treatment 147720.0 -12100.0 -0.47 154360.0 -23400.0 -0.88 -0.9544 -0.957 1484690 ChemDiv3_004196 OC(=O)CCNc1ncnc2sc3CCCCc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O17 compound treatment 142720.0 -17100.0 -0.66 184520.0 6730.0 0.25 -0.2912 -0.4097 3120036 ChemDiv3_004197 C=CCN1[C@H]2CS(=O)(=O)C[C@H]2NC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O18 compound treatment 113920.0 -45900.0 -1.78 163840.0 -14000.0 -0.52 -1.6301 -0.8778 1564957 ChemDiv3_004198 CCOc1ccc(cc1)C2C3=C(CCCC3=O)NC4=C2C(=O)CCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O19 compound treatment 173760.0 13900.0 0.54 173160.0 -4630.0 -0.17 0.259 0.4565 3023723 ChemDiv3_004199 CC1=CS(=O)(=O)CC1Sc2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O20 compound treatment 92520.0 -67300.0 -2.61 114360.0 -63400.0 -2.38 -3.5304 -0.9989 1479636 ChemDiv3_004200 Cc1oc(cc1COc2ccc3c4CCCCc4c(=O)oc3c2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O21 compound treatment 171880.0 12000.0 0.47 179080.0 1290.0 0.05 0.3645 0.7762 3023725 ChemDiv3_004201 Cc1nc2sc3CCCCc3c2c4nnc(SCC(=O)c5ccccc5)n14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O22 compound treatment 55080.0 -105000.0 -4.06 67920.0 -110000.0 -4.12 -5.7901 -1.0 3120037 ChemDiv3_004202 CC1CCC2(CC1)NN(C(=S)N2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O23 mock treatment 156120.0 -3720.0 -0.14 197320.0 19500.0 0.73 0.4162 0.5571 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 O24 mock treatment 173040.0 13200.0 0.51 178000.0 209.0 0.01 0.3677 0.7178 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P01 compound treatment 170640.0 10800.0 0.42 182480.0 4690.0 0.18 0.4207 0.9258 3120038 ChemDiv3_004203 COCCN1C(=O)N(C(=O)/C(=C\c2cc(C)n(c2C)c3ccncc3)/C1=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P02 compound treatment 167400.0 7560.0 0.29 166280.0 -11500.0 -0.43 -0.0981 -0.1879 3023728 ChemDiv3_004204 CCc1c(C)[n+]([O-])c2CCCCCc2[n+]1[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P03 compound treatment 129600.0 -30200.0 -1.17 137960.0 -39800.0 -1.49 -1.8868 -0.9928 3023729 ChemDiv3_004205 COC(=O)c1ccc(OCC(O)Cn2c(C)[n+](C)c3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P04 compound treatment 165080.0 5240.0 0.2 165240.0 -12600.0 -0.47 -0.1894 -0.3691 3120039 ChemDiv3_004206 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCN(CC3)C(=O)c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P05 compound treatment 134360.0 -25500.0 -0.99 111800.0 -66000.0 -2.48 -2.4504 -0.9189 3023733 ChemDiv3_004207 O=C(ON1C(=O)c2ccccc2C1=O)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P06 compound treatment 159480.0 -361.0 -0.01 161160.0 -16600.0 -0.62 -0.4513 -0.7228 1192417 ChemDiv3_004208 COc1cc(cc(OC)c1OC)C2C3=C(CCCC3=O)Nc4[nH]c(=O)[nH]c(=O)c24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P07 compound treatment 148320.0 -11500.0 -0.45 153840.0 -24000.0 -0.9 -0.9517 -0.948 3120040 ChemDiv3_004209 CC(=O)Nc1ccc(cc1)S(=O)(=O)N=C2NCN(CCOC(=O)c3ccccc3)CN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P08 compound treatment 121760.0 -38100.0 -1.48 127560.0 -50200.0 -1.89 -2.3779 -0.9927 3023735 ChemDiv3_004210 COC(=O)c1c(C)nn(c1NC(=O)C(C)Oc2ccc(Cl)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P09 compound treatment 158200.0 -1640.0 -0.06 152080.0 -25700.0 -0.96 -0.7274 -0.7521 1521251 ChemDiv3_004211 Cc1cc2nnn(c3nc(C)nc4sc5CCCCc5c34)c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P10 compound treatment 255640.0 95800.0 3.72 154160.0 -23600.0 -0.89 2.0012 0.5237 3023737 ChemDiv3_004212 CSc1nc(C)cc(NC(=O)N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P11 compound treatment 137680.0 -22200.0 -0.86 152560.0 -25200.0 -0.95 -1.2776 -0.9988 1165643 ChemDiv3_004213 CC(C)(C)c1ccc(cc1)c2cc3ccccn3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P12 compound treatment 138320.0 -21500.0 -0.84 127880.0 -49900.0 -1.87 -1.915 -0.9337 1379043 ChemDiv3_004214 Fc1ccccc1Nc2nc3ccccc3nc2NS(=O)(=O)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P13 compound treatment 149000.0 -10800.0 -0.42 164360.0 -13400.0 -0.5 -0.6539 -0.996 3120041 ChemDiv3_004215 Cc1cc(C(=O)CSc2ncnc3sc4CCCCc4c23)c(C)n1Cc5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P14 compound treatment 59200.0 -101000.0 -3.9 66560.0 -111000.0 -4.17 -5.7131 -0.9994 3024070 ChemDiv3_004216 CN1C(=O)/C(=C/Nc2cccc(Cl)c2)/c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P15 compound treatment 151880.0 -7960.0 -0.31 157440.0 -20400.0 -0.76 -0.7585 -0.9206 1257595 ChemDiv3_004217 OC(=O)CSc1nnc-2c(OC3(CCCC3)Nc4ccccc42)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P16 compound treatment 115240.0 -44600.0 -1.73 118920.0 -58900.0 -2.21 -2.7861 -0.9927 3024074 ChemDiv3_004218 CN1C(=O)/C(=C\Nc2cccc(CO)c2)/c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P17 compound treatment 137960.0 -21900.0 -0.85 163200.0 -14600.0 -0.55 -0.9876 -0.9775 3120042 ChemDiv3_004219 Cc1ccc(Oc2ncnc3sccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P18 compound treatment 156640.0 -3200.0 -0.12 162400.0 -15400.0 -0.58 -0.4963 -0.84 3024079 ChemDiv3_004220 CC1=N/C(=C/c2cc3ccccc3nc2Sc4ccc(C)cc4)/C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P19 compound treatment 152200.0 -7640.0 -0.3 206120.0 28300.0 1.06 0.5422 0.4912 1244804 ChemDiv3_004221 COc1ccc(cc1OC)C(=O)Nn2c(C)nnc2n3nc(C)cc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P20 compound treatment 143600.0 -16200.0 -0.63 143080.0 -34700.0 -1.3 -1.3668 -0.9445 3120043 ChemDiv3_004222 CC(C)CN(CC(C)C)CN1CC(COc2ccccc2C)OC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P21 compound treatment 138960.0 -20900.0 -0.81 148000.0 -29800.0 -1.12 -1.3635 -0.9875 3023284 ChemDiv3_004223 COC(=O)C1=CN(C=C(C1c2cccc(OC)c2)C(=O)OC)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P22 compound treatment 121480.0 -38400.0 -1.49 131520.0 -46300.0 -1.74 -2.2805 -0.9971 1820755 ChemDiv3_004224 O=C(CSc1nnnn1c2ccccc2)N3c4ccccc4CCc5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P23 mock treatment 169480.0 9640.0 0.37 159880.0 -17900.0 -0.67 -0.2109 -0.2742 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2012 P24 mock treatment 168560.0 8720.0 0.34 156280.0 -21500.0 -0.81 -0.3317 -0.3789 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A01 compound treatment 201640.0 34400.0 1.33 149400.0 -14700.0 -0.55 0.5547 0.3842 3027680 ChemDiv3_007041 FC(F)(F)c1cc(nc(SCCCC(=O)NC2CCCC2)n1)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A02 compound treatment 7840.0 -159000.0 -6.18 6480.0 -158000.0 -5.91 -8.5553 -0.9998 3118293 ChemDiv3_007042 CC(C)CCNC(=O)c1c(C)oc2C(=O)c3ccccc3C(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A03 compound treatment 196560.0 29300.0 1.14 160720.0 -3350.0 -0.13 0.7158 0.6253 1788862 ChemDiv3_007043 O=C(Nc1cccnc1)c2nc3ncccn3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A04 compound treatment 102840.0 -64400.0 -2.5 112440.0 -51600.0 -1.94 -3.1368 -0.9921 1875739 ChemDiv3_007044 OC(=O)c1ccc(NS(=O)(=O)c2cc3C(=O)NC(=O)c4cccc(c2)c43)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A05 compound treatment 10720.0 -157000.0 -6.07 10080.0 -154000.0 -5.78 -8.3808 -0.9997 3027681 ChemDiv3_007045 COC(=O)CSC1=C(C#N)C(=O)NC(S1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A06 compound treatment 163160.0 -4070.0 -0.16 170400.0 6330.0 0.24 0.0563 0.1972 3118294 ChemDiv3_007046 COc1ccc2[nH]c(SCc3cnc(C)nc3N)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A07 compound treatment 169800.0 2570.0 0.1 172840.0 8770.0 0.33 0.3032 0.8814 3027682 ChemDiv3_007047 CCSC1=C(C#N)C(=O)NC(CO)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A08 compound treatment 12480.0 -155000.0 -6.0 92440.0 -71600.0 -2.69 -6.1467 -0.9343 3118295 ChemDiv3_007048 Clc1ccc(cc1)C2C3=C(Nc4ccccc4S2(=O)=O)c5ccccc5C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A09 compound treatment 157280.0 -9950.0 -0.39 157840.0 -6230.0 -0.23 -0.4384 -0.971 3118296 ChemDiv3_007049 CC1(C)OC[C@H](O1)[C@H](O)P(=O)(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A10 compound treatment 156000.0 -11200.0 -0.44 198240.0 34200.0 1.28 0.5987 0.442 3027683 ChemDiv3_007050 CC(C)N1CNC(=NC1)Nc2nc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A11 compound treatment 160320.0 -6910.0 -0.27 175120.0 11100.0 0.41 0.1036 0.2098 3118297 ChemDiv3_007051 CCOc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)N4C(C)CCCC4C)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A12 compound treatment 111200.0 -56000.0 -2.17 85520.0 -78500.0 -2.95 -3.6219 -0.9888 3027684 ChemDiv3_007052 CC(C)CCN1C(=O)c2ccc(cc2C1=O)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A13 compound treatment 152440.0 -14800.0 -0.57 162880.0 -1190.0 -0.04 -0.4374 -0.7597 3118298 ChemDiv3_007053 CCCn1cc(C(CC(=O)O)C(=O)O)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A14 compound treatment 157680.0 -9550.0 -0.37 187360.0 23300.0 0.87 0.356 0.3749 1748461 ChemDiv3_007054 CCOC(=O)c1cnc(SCC(=O)N2CCc3ccccc23)nc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A15 compound treatment 124560.0 -42700.0 -1.66 109760.0 -54300.0 -2.04 -2.6121 -0.9947 3027685 ChemDiv3_007055 COc1ccc(cc1)N2CCc3c2n4c5ccccc5nc4c(C#N)c3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A16 compound treatment 152240.0 -15000.0 -0.58 152120.0 -11900.0 -0.45 -0.7284 -0.9917 3118299 ChemDiv3_007056 O=C(CSc1nc2ccccc2nc1N3CCOCC3)NCc4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A17 compound treatment 162920.0 -4310.0 -0.17 168200.0 4130.0 0.16 -0.0087 -0.038 3027686 ChemDiv3_007057 Cn1c(=O)[nH]c(=O)c2n(CC=C)cnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A18 compound treatment 36840.0 -130000.0 -5.06 29880.0 -134000.0 -5.04 -7.1387 -1.0 3118300 ChemDiv3_007058 Oc1ccc2c(CSc3cccc4cccnc34)cc(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A19 compound treatment 158120.0 -9110.0 -0.35 167960.0 3890.0 0.15 -0.1467 -0.3835 1612422 ChemDiv3_007059 Cc1cc(O)nc(SCc2cn3c(C)cc(C)nc3n2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A20 compound treatment 160200.0 -7030.0 -0.27 161760.0 -2310.0 -0.09 -0.2542 -0.8878 3027740 ChemDiv3_007060 CN(C)C1=NC(N=C(O1)c2ccccc2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A21 compound treatment 111560.0 -55700.0 -2.16 115160.0 -48900.0 -1.84 -2.8254 -0.9967 3118301 ChemDiv3_007061 S1C(C(=Nc2ccccc12)c3ccccc3)c4nc5ccccc5[nH]4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A22 compound treatment 111080.0 -56200.0 -2.18 95080.0 -69000.0 -2.59 -3.3715 -0.9963 3027741 ChemDiv3_007062 CN(C)C1=NC(c2c(C)nn(c2O1)c3ccccc3)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A23 mock treatment 161960.0 -5270.0 -0.2 147760.0 -16300.0 -0.61 -0.5775 -0.8949 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 A24 mock treatment 173400.0 6170.0 0.24 161440.0 -2630.0 -0.1 0.0994 0.3844 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B01 compound treatment 13400.0 -154000.0 -5.97 20840.0 -143000.0 -5.38 -8.0217 -0.9986 1198210 ChemDiv3_007063 Oc1c(ccc2cccnc12)C(N3CCCC3)c4ccncc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B02 compound treatment 207960.0 40700.0 1.58 164600.0 534.0 0.02 1.1315 0.716 1284982 ChemDiv3_007064 OCCNC(=O)c1ccc(cc1)N2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B03 compound treatment 10480.0 -157000.0 -6.08 10000.0 -154000.0 -5.78 -8.3895 -0.9997 1247906 ChemDiv3_007065 CC(C)C(c1c(C)[nH]c2ccccc12)c3c(C)[nH]c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B04 compound treatment 175720.0 8490.0 0.33 168040.0 3970.0 0.15 0.3383 0.9359 3027742 ChemDiv3_007066 Cc1ccc(NC(=O)CSC(=N)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B05 compound treatment 148480.0 -18800.0 -0.73 175480.0 11400.0 0.43 -0.2116 -0.2506 3118302 ChemDiv3_007067 COc1ccc2cc(sc(=O)c2c1OC)C(=O)Nc3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B06 compound treatment 170200.0 2970.0 0.12 179200.0 15100.0 0.57 0.483 0.8334 1627380 ChemDiv3_007068 CCN(CC)Cn1cnc2c(SC)ncnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B07 compound treatment 153000.0 -14200.0 -0.55 177160.0 13100.0 0.49 -0.0431 -0.0582 3118303 ChemDiv3_007069 CC1(C)C2(C)CCC1(C(=O)O)c3nc4ccc5ncccc5c4nc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B08 compound treatment 77760.0 -89500.0 -3.47 161320.0 -2750.0 -0.1 -2.5277 -0.7278 3027743 ChemDiv3_007070 Clc1ccc(CC2(C(=O)c3ccccc3C2=O)c4ccc(Cl)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B09 compound treatment 144520.0 -22700.0 -0.88 150560.0 -13500.0 -0.51 -0.9816 -0.9655 3118304 ChemDiv3_007071 Cc1c(oc2CC(C)(C)CC(=O)c12)C(=O)N3CCc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B10 compound treatment 102440.0 -64800.0 -2.51 101240.0 -62800.0 -2.36 -3.445 -0.9995 1618272 ChemDiv3_007072 CCN(CC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2ccc3OC(C)(C)Oc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B11 compound treatment 174680.0 7450.0 0.29 152520.0 -11500.0 -0.43 -0.1022 -0.1962 3027744 ChemDiv3_007073 Cc1ccc(cc1)S(=O)(=O)c2nc(c(NCc3ccco3)s2)S(=O)(=O)c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B12 compound treatment 57280.0 -110000.0 -4.27 51920.0 -112000.0 -4.21 -5.993 -1.0 3118305 ChemDiv3_007074 COc1ccc(cc1)C(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B13 compound treatment 155200.0 -12000.0 -0.47 165080.0 1010.0 0.04 -0.3033 -0.6473 3118306 ChemDiv3_007075 COc1ccc(cc1)C2C(=C(N)Oc3cc(C)n(CCc4ccc(OC)c(OC)c4)c(=O)c23)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B14 compound treatment 175040.0 7810.0 0.3 183080.0 19000.0 0.71 0.7187 0.9272 1516177 ChemDiv3_007076 O=C(NCc1ccc2OCOc2c1)c3ccc4c(=O)n(Cc5ccccc5)c(=S)[nH]c4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B15 compound treatment 176560.0 9330.0 0.36 205840.0 41800.0 1.57 1.3645 0.848 3118307 ChemDiv3_007077 CN(C)CCn1c(C)cc2OC(=C(C#N)C(c3ccncc3)c2c1=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B16 compound treatment 152360.0 -14900.0 -0.58 153480.0 -10600.0 -0.4 -0.6891 -0.9834 3027745 ChemDiv3_007078 CCOc1ccc(NC(=O)CCNC(=O)c2cn(c3cccc(OC)c3)c(=O)c4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B17 compound treatment 138840.0 -28400.0 -1.1 157440.0 -6630.0 -0.25 -0.9549 -0.8455 3118308 ChemDiv3_007079 Fc1ccc(NP2(=O)COc3ccccc3OC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B18 compound treatment 133720.0 -33500.0 -1.3 162720.0 -1350.0 -0.05 -0.9552 -0.734 3118309 ChemDiv3_007080 CC1(C)CC(=O)C2=C(C1)N(CCN3CCOCC3)C4=C(C2c5cccc(Cl)c5)C(=O)CC(C)(C)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B19 compound treatment 9480.0 -158000.0 -6.12 14720.0 -149000.0 -5.61 -8.2916 -0.999 3027746 ChemDiv3_007081 CC[n+]1c(/C=C/2\SC=CN2C)cc(C)c3cc(OC)c4ccccc4c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B20 compound treatment 9560.0 -158000.0 -6.12 9960.0 -154000.0 -5.78 -8.4158 -0.9996 3118310 ChemDiv3_007082 CCOC(=O)c1cnc2c(OC)cccc2c1N3CC(C)CC(C)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B21 compound treatment 139560.0 -27700.0 -1.07 110640.0 -53400.0 -2.01 -2.1772 -0.9572 3027747 ChemDiv3_007083 S(c1ccc(/C=N/c2cccc3ccccc23)o1)c4nnnn4c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B22 compound treatment 152400.0 -14800.0 -0.58 162960.0 -1110.0 -0.04 -0.4364 -0.7561 3118432 ChemDiv3_007084 CCOc1ccc2n(CC)/c(=N/C(=O)c3ccc(cc3)S(=O)(=O)N4CCCCC4C)/sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B23 mock treatment 185640.0 18400.0 0.71 165640.0 1570.0 0.06 0.5467 0.763 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 B24 mock treatment 154320.0 -12900.0 -0.5 168040.0 3970.0 0.15 -0.2489 -0.476 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C01 compound treatment 199200.0 32000.0 1.24 156360.0 -7710.0 -0.29 0.6725 0.528 3027748 ChemDiv3_007085 FC(F)(F)c1cc(nc(OCC(=O)NCC=C)n1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C02 compound treatment 8960.0 -158000.0 -6.14 9560.0 -155000.0 -5.8 -8.4428 -0.9996 3118433 ChemDiv3_007086 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C03 compound treatment 174640.0 7410.0 0.29 164400.0 334.0 0.01 0.212 0.7372 1788886 ChemDiv3_007087 CCOC(=O)c1c(NC(=O)c2nc3ncccn3n2)sc4CC(CC)CCc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C04 compound treatment 164440.0 -2790.0 -0.11 167440.0 3370.0 0.13 0.0129 0.0771 3027749 ChemDiv3_007088 OC(=O)CCC(=O)N(Cc1cn(nc1c2cccnc2)c3ccccc3)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C05 compound treatment 136960.0 -30300.0 -1.17 153600.0 -10500.0 -0.39 -1.1084 -0.8949 3118434 ChemDiv3_007089 COC(=O)CSC1=C(C#N)C(=O)NC(S1)c2ccccc2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C06 compound treatment 9960.0 -157000.0 -6.1 12120.0 -152000.0 -5.7 -8.3475 -0.9994 3027750 ChemDiv3_007090 Cc1ccc(cc1)n2sc3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C07 compound treatment 10520.0 -157000.0 -6.08 13280.0 -151000.0 -5.66 -8.3013 -0.9994 3118435 ChemDiv3_007091 Oc1ccccc1C2NC(=O)C(=C(SCc3ccccc3)S2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C08 compound treatment 161680.0 -5550.0 -0.22 158080.0 -5990.0 -0.22 -0.3113 -0.9998 3027751 ChemDiv3_007092 Cn1c2NCN(Cc2c(=O)n(C)c1=O)C3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C09 compound treatment 175960.0 8730.0 0.34 207680.0 43600.0 1.64 1.3968 0.8357 1528851 ChemDiv3_007093 CCOc1cccc2cc(c3nc4ccccc4s3)c(=O)oc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C10 compound treatment 170400.0 3170.0 0.12 168520.0 4450.0 0.17 0.205 0.9885 3118436 ChemDiv3_007094 C1NC(=NCN1C2CCCCCC2)Nc3nc4ccccc4s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C11 compound treatment 187560.0 20300.0 0.79 149840.0 -14200.0 -0.53 0.1801 0.1891 3027752 ChemDiv3_007095 CCN(CC)C(=O)C1Sc2nnc(c3ccccc3)n2NC1c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C12 compound treatment 163160.0 -4070.0 -0.16 170120.0 6050.0 0.23 0.0489 0.1765 3118437 ChemDiv3_007096 CCC(=O)c1cn(CC(=O)NCCOc2ccc(Cl)cc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C13 compound treatment 155120.0 -12100.0 -0.47 166760.0 2690.0 0.1 -0.2609 -0.5426 3118438 ChemDiv3_007097 COc1ccc(cc1)N2C(=O)CC(C2=O)c3cn(Cc4ccccc4)c5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C14 compound treatment 162720.0 -4510.0 -0.18 169920.0 5850.0 0.22 0.0315 0.112 3027753 ChemDiv3_007098 Nc1c(C#N)cnc2c(c(COc3ccccc3)nn12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C15 compound treatment 171240.0 4010.0 0.16 165800.0 1730.0 0.07 0.1559 0.9253 3027754 ChemDiv3_007099 CC1=NNC(=O)C1CCc2ccncc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C16 compound treatment 145760.0 -21500.0 -0.83 161080.0 -2990.0 -0.11 -0.6684 -0.7951 3118439 ChemDiv3_007100 O=C(CSc1nc2ccccc2nc1N3CCOCC3)N4CCC5(CC4)OCCO5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C17 compound treatment 172840.0 5610.0 0.22 164560.0 494.0 0.02 0.1669 0.7646 3027755 ChemDiv3_007101 CSc1ccn(Cc2ccc(Cl)cc2)c(=O)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C18 compound treatment 175680.0 8450.0 0.33 175200.0 11100.0 0.42 0.5272 0.9928 3118440 ChemDiv3_007102 CCCOc1ccc(cc1)/C(=N\O)/C(C)(C)NO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C19 compound treatment 160640.0 -6590.0 -0.26 158240.0 -5830.0 -0.22 -0.3356 -0.9969 3118441 ChemDiv3_007103 CCS(=O)(=O)Nc1cccc(c1)C(=O)CC2(O)C(=O)Nc3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C20 compound treatment 155360.0 -11900.0 -0.46 149000.0 -15100.0 -0.57 -0.7256 -0.9948 3026802 ChemDiv3_007104 CC1=CC2=NC(NC(=O)N2C=C1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C21 compound treatment 176720.0 9490.0 0.37 152280.0 -11800.0 -0.44 -0.0526 -0.0913 3026803 ChemDiv3_007105 CCOc1ccc(cc1)C2C3=C(CCCC3=O)Nc4ncnn24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C22 compound treatment 159720.0 -7510.0 -0.29 158040.0 -6030.0 -0.23 -0.3661 -0.9921 3118442 ChemDiv3_007106 CCC1=NC(C2=C(CC(C)(C)CC2=O)N1Cc3ccccc3)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C23 mock treatment 173000.0 5770.0 0.22 148320.0 -15700.0 -0.59 -0.2597 -0.411 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 C24 mock treatment 175320.0 8090.0 0.31 176600.0 12500.0 0.47 0.5545 0.9806 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D01 compound treatment 7360.0 -160000.0 -6.2 7760.0 -156000.0 -5.87 -8.5345 -0.9996 1621903 ChemDiv3_007107 CN1CCN(CC1)C(c2c(C)[nH]c3ccccc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D02 compound treatment 141040.0 -26200.0 -1.02 201280.0 37200.0 1.4 0.2689 0.1557 3026804 ChemDiv3_007108 Cc1ccsc1/C=N/c2ccc(Cl)cc2C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D03 compound treatment 142360.0 -24900.0 -0.97 155640.0 -8430.0 -0.32 -0.9061 -0.8921 1681432 ChemDiv3_007109 Cc1ccc(cc1)C(=O)OC(c2ccccc2)c3nccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D04 compound treatment 33880.0 -133000.0 -5.17 55320.0 -109000.0 -4.08 -6.5447 -0.9931 1346036 ChemDiv3_007110 CCOc1nc(NC2CCCC2)nc(n1)N3CCC(C)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D05 compound treatment 160000.0 -7230.0 -0.28 172000.0 7930.0 0.3 0.0121 0.0295 3118443 ChemDiv3_007111 Cc1sc2N(CN(Cc2c1C)C(C)(C)C)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D06 compound treatment 161080.0 -6150.0 -0.24 172360.0 8290.0 0.31 0.0512 0.1306 1643537 ChemDiv3_007112 CCOC(=O)N1N=C(C)CC1(O)c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D07 compound treatment 169920.0 2690.0 0.1 172800.0 8730.0 0.33 0.3055 0.8881 3118444 ChemDiv3_007113 O(c1ccc2nccnc2c1)c3ccc4nccnc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D08 compound treatment 187800.0 20600.0 0.8 193320.0 29300.0 1.1 1.3406 0.9877 3026805 ChemDiv3_007114 CN(C)c1ccc(cc1)c2nc(S)[nH]c(=O)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D09 compound treatment 164360.0 -2870.0 -0.11 166960.0 2890.0 0.11 -0.0021 -0.0133 3118445 ChemDiv3_007115 CN1CCN(CC1)C(=O)c2oc3CC(C)(C)CC(=O)c3c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D10 compound treatment 176680.0 9450.0 0.37 150560.0 -13500.0 -0.51 -0.0993 -0.1588 1345726 ChemDiv3_007116 CC(C)(C)N1NC2(CCCCC2)NC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D11 compound treatment 14160.0 -153000.0 -5.94 15560.0 -149000.0 -5.57 -8.1409 -0.9995 1384630 ChemDiv3_007117 CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(N2CCOCC2)c3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D12 compound treatment 148200.0 -19000.0 -0.74 156040.0 -8030.0 -0.3 -0.7352 -0.9218 3118446 ChemDiv3_007118 Cc1ccccc1NC(=O)c2cnn3c(cc(nc23)c4ccco4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D13 compound treatment 161640.0 -5590.0 -0.22 151400.0 -12700.0 -0.48 -0.4896 -0.9369 1444379 ChemDiv3_007119 COC(=O)C1=C(N)Oc2cc(C)oc(=O)c2C1c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D14 compound treatment 155920.0 -11300.0 -0.44 183040.0 19000.0 0.71 0.1931 0.2308 1441733 ChemDiv3_007120 COc1ccc(NC(=O)c2ccc3c(=O)n(CCc4ccccc4)c(=S)[nH]c3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D15 compound treatment 181320.0 14100.0 0.55 156680.0 -7390.0 -0.28 0.1904 0.3107 3026806 ChemDiv3_007121 COC(=O)C1=C(N)Oc2cc(C)n(Cc3ccccc3)c(=O)c2C1c4ccncc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D16 compound treatment 171920.0 4690.0 0.18 148680.0 -15400.0 -0.58 -0.2798 -0.4622 3118447 ChemDiv3_007122 COc1ccccc1n2cc(C(=O)NCC(=O)NCC3COc4ccccc4O3)c5ccccc5c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D17 compound treatment 165440.0 -1790.0 -0.07 153080.0 -11000.0 -0.41 -0.3408 -0.815 3026807 ChemDiv3_007123 Clc1ccc(cc1)N2CCN(CC2)P3(=O)COc4ccccc4OC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D18 compound treatment 191960.0 24700.0 0.96 196840.0 32800.0 1.23 1.5481 0.9924 3118448 ChemDiv3_007124 Nc1cc(OC(=O)c2ccccc2)nn1S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D19 compound treatment 14600.0 -153000.0 -5.92 16360.0 -148000.0 -5.54 -8.1076 -0.9995 3026808 ChemDiv3_007125 COc1ccc2N(C)/C(=C/c3sc4ccccc4[n+]3C)/C=Cc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D20 compound treatment 84320.0 -82900.0 -3.22 38600.0 -125000.0 -4.71 -5.6046 -0.9827 3118449 ChemDiv3_007126 CCOC(=O)c1cnc2ccc(OCC)cc2c1NC(C)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D21 compound treatment 158320.0 -8910.0 -0.35 151920.0 -12100.0 -0.46 -0.5669 -0.9907 1344877 ChemDiv3_007127 O=C(C1CN(C(=O)C1)c2ccccc2)N(Cc3ccccc3)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D22 compound treatment 125360.0 -41900.0 -1.62 157240.0 -6830.0 -0.26 -1.33 -0.8086 3026809 ChemDiv3_007128 CCn1/c(=N/C(=O)c2ccc(cc2)S(=O)(=O)N(C)C)/sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D23 mock treatment 169800.0 2570.0 0.1 151880.0 -12200.0 -0.46 -0.253 -0.5406 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 D24 mock treatment 158560.0 -8670.0 -0.34 172520.0 8450.0 0.32 -0.0136 -0.0295 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E01 compound treatment 128320.0 -38900.0 -1.51 140760.0 -23300.0 -0.87 -1.6862 -0.9663 3118450 ChemDiv3_007129 CC1CCN(C(C)C1)C(=O)c2cc3nc(cc(n3n2)C(F)(F)F)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E02 compound treatment 9520.0 -158000.0 -6.12 9880.0 -154000.0 -5.79 -8.419 -0.9996 3026810 ChemDiv3_007130 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NC4CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E03 compound treatment 162440.0 -4790.0 -0.19 171920.0 7850.0 0.29 0.0769 0.2206 3118451 ChemDiv3_007131 CN(C1CCCCC1)C(=O)c2cc3nc(cc(n3n2)C(F)(F)F)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E04 compound treatment 176200.0 8970.0 0.35 198560.0 34500.0 1.29 1.1614 0.8664 3118452 ChemDiv3_007132 CCc1nc(SCS(=O)(=O)c2ccc(C)cc2)c(C#N)c3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E05 compound treatment 12480.0 -155000.0 -6.0 13560.0 -151000.0 -5.65 -8.2401 -0.9995 3026811 ChemDiv3_007133 CCSC1=C(C#N)C(=O)NC(S1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E06 compound treatment 182400.0 15200.0 0.59 189080.0 25000.0 0.94 1.0799 0.9747 3118573 ChemDiv3_007134 OC(=O)c1ccn(Cn2cnc3ccccc23)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E07 compound treatment 40640.0 -127000.0 -4.91 27280.0 -137000.0 -5.13 -7.1034 -0.9998 3026812 ChemDiv3_007135 CC1NC(=O)C(=C(SCc2ccccc2)S1)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E08 compound treatment 150480.0 -16800.0 -0.65 183920.0 19900.0 0.75 0.0672 0.068 3118574 ChemDiv3_007136 Clc1cccc(NC(=O)CC2N(CCNC2=O)C(=O)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E09 compound treatment 167240.0 5.16 0.0 157840.0 -6230.0 -0.23 -0.1651 -0.7065 3118575 ChemDiv3_007137 COc1ccc(cc1Cl)C2Nn3c(C)nnc3SC2C(=O)NCc4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E10 compound treatment 164200.0 -3030.0 -0.12 201960.0 37900.0 1.42 0.9224 0.6464 3026813 ChemDiv3_007138 Clc1ccc(SCc2cc(=O)[nH]c(n2)N3CCN(Cc4ccc5OCOc5c4)CC3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E11 compound treatment 164720.0 -2510.0 -0.1 166040.0 1970.0 0.07 -0.0166 -0.1356 3118576 ChemDiv3_007139 Cc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)NCC4CCCO4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E12 compound treatment 143560.0 -23700.0 -0.92 137840.0 -26200.0 -0.98 -1.3456 -0.9994 3026814 ChemDiv3_007140 CCOC(=O)C(C)N1c2cccc3cccc(c23)S1(=O)=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E13 compound treatment 165440.0 -1790.0 -0.07 163000.0 -1070.0 -0.04 -0.0775 -0.9654 3118577 ChemDiv3_007141 CC(C)CN1CC(CC1=O)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E14 compound treatment 181000.0 13800.0 0.53 164760.0 694.0 0.03 0.3961 0.7407 3026815 ChemDiv3_007142 Clc1ccc2OCC(=O)N(CC(=O)N3CCCC3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E15 compound treatment 176760.0 9530.0 0.37 169520.0 5450.0 0.2 0.4061 0.9612 1116771 ChemDiv3_007143 OC(=O)Cc1nc2ccccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E16 compound treatment 164040.0 -3190.0 -0.12 160720.0 -3350.0 -0.13 -0.1765 -1.0 3118578 ChemDiv3_007144 Clc1ccc(CCNC(=O)CSc2nc3ccccc3nc2N4CCCC4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E17 compound treatment 185240.0 18000.0 0.7 164920.0 854.0 0.03 0.5166 0.7388 1549546 ChemDiv3_007145 Cn1c(NCc2ccco2)nc3n(C)c(=O)n(C)c(=O)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E18 compound treatment 175440.0 8210.0 0.32 162640.0 -1430.0 -0.05 0.1873 0.5801 3118579 ChemDiv3_007146 Cc1ccc2c(C)nc(NC(=N)NS(=O)(=O)c3ccccc3)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E19 compound treatment 180360.0 13100.0 0.51 178840.0 14800.0 0.55 0.7522 0.9991 3026816 ChemDiv3_007147 COc1ccc(NC(=O)C(C)C2SC(=O)NC2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E20 compound treatment 123240.0 -44000.0 -1.71 125960.0 -38100.0 -1.43 -2.2183 -0.9961 3118580 ChemDiv3_007148 Cc1cccc(c1)C2=NC(c3c(N2)n(C)c(=O)n(C)c3=O)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E21 compound treatment 173600.0 6370.0 0.25 170320.0 6250.0 0.23 0.3406 0.9997 3026817 ChemDiv3_007149 CCC1=C(C(c2ccc(Br)cc2)n3ncnc3N1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E22 compound treatment 164160.0 -3070.0 -0.12 195560.0 31500.0 1.18 0.7515 0.6325 3118581 ChemDiv3_007150 CC1(C)CC(=O)C2=C(C1)N(Cc3ccco3)C(=O)NC2(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E23 mock treatment 166760.0 -475.0 -0.02 155160.0 -8910.0 -0.33 -0.2494 -0.7449 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 E24 mock treatment 169800.0 2570.0 0.1 172960.0 8890.0 0.33 0.3064 0.8797 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F01 compound treatment 23600.0 -144000.0 -5.57 19800.0 -144000.0 -5.41 -7.7694 -0.9999 1293985 ChemDiv3_007151 Oc1c(ccc2cccnc12)C(Nc3cccc(Cl)c3)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F02 compound treatment 153600.0 -13600.0 -0.53 179200.0 15100.0 0.57 0.0275 0.0355 3118582 ChemDiv3_007152 CC(NC(=O)CSc1nc2ccc(/N=C/c3ccccc3O)cc2s1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F03 compound treatment 162000.0 -5230.0 -0.2 185080.0 21000.0 0.79 0.4141 0.5084 1225945 ChemDiv3_007153 OC1(CCN(CC1C(=O)c2ccccc2)C3CCS(=O)(=O)C3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F04 compound treatment 198680.0 31400.0 1.22 189160.0 25100.0 0.94 1.5287 0.9918 3118583 ChemDiv3_007154 O=C(CSc1nc2ccc(cc2s1)N3C(=O)c4ccccc4C3=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F05 compound treatment 166640.0 -595.0 -0.02 152440.0 -11600.0 -0.44 -0.3249 -0.7435 3026871 ChemDiv3_007155 CCN(CC)CCN1CN(C(=O)c2ccccc2)c3sc(C)c(C)c3C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F06 compound treatment 23440.0 -144000.0 -5.58 25360.0 -139000.0 -5.21 -7.6263 -0.9994 3118584 ChemDiv3_007156 CCOc1ccc(cc1)N2C(=O)/C(=C/c3cccs3)/C(=O)N(C2=S)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F07 compound treatment 151480.0 -15800.0 -0.61 159280.0 -4790.0 -0.18 -0.5593 -0.8778 1868012 ChemDiv3_007157 CNC(=O)Cc1coc2ccc3ccccc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F08 compound treatment 179960.0 12700.0 0.49 164840.0 774.0 0.03 0.3697 0.7474 3118585 ChemDiv3_007158 O=C(CSc1ncccn1)Nc2nccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F09 compound treatment 153520.0 -13700.0 -0.53 168560.0 4490.0 0.17 -0.257 -0.4604 3026872 ChemDiv3_007159 Cc1ccc2cc3CCN(Cc4ccco4)c3nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F10 compound treatment 14600.0 -153000.0 -5.92 16720.0 -147000.0 -5.53 -8.0981 -0.9994 3118586 ChemDiv3_007160 CCOc1cccc(NC(=O)C2CC(=O)N(/N=C(\C)/c3ccc(Br)s3)C(=N)S2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F11 compound treatment 14800.0 -152000.0 -5.91 15840.0 -148000.0 -5.56 -8.116 -0.9995 3118587 ChemDiv3_007161 CCOC(=O)c1ccc2nc(nc(NCCCc3ccccc3)c2c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F12 compound treatment 178360.0 11100.0 0.43 163520.0 -546.0 -0.02 0.2907 0.6728 1635368 ChemDiv3_007162 O=C(NCc1ccccc1)c2ccc3c(=O)n(CCc4ccccc4)c(SCC#N)nc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F13 compound treatment 195320.0 28100.0 1.09 173200.0 9130.0 0.34 1.0129 0.8867 3118588 ChemDiv3_007163 Cc1cc2OC(=C(C#N)C(c3cccc(F)c3)c2c(=O)n1CCN4CCOCC4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F14 compound treatment 176720.0 9490.0 0.37 179120.0 15100.0 0.56 0.6597 0.9784 1650732 ChemDiv3_007164 COc1ccc(OC)c(c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)NCc4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F15 compound treatment 181360.0 14100.0 0.55 213160.0 49100.0 1.84 1.6904 0.8794 3026873 ChemDiv3_007165 CC(C)c1ccc(cc1)C2C(=C(N)Oc3cc(C)[nH]c(=O)c23)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F16 compound treatment 183200.0 16000.0 0.62 161040.0 -3030.0 -0.11 0.3577 0.568 1236286 ChemDiv3_007166 O=C(CCN1C(=O)C2CC=CCC2C1=O)N3CCN(CC3)c4ccccn4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F17 compound treatment 176400.0 9170.0 0.36 166760.0 2690.0 0.1 0.3229 0.8735 3026874 ChemDiv3_007167 O=P1(COc2ccccc2OC1)Nc3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F18 compound treatment 184640.0 17400.0 0.68 195720.0 31700.0 1.19 1.3176 0.9642 3026875 ChemDiv3_007168 COc1ccc(cc1)S(=O)(=O)n2nc(OC(=O)C(C)(C)C)cc2N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F19 compound treatment 171240.0 4010.0 0.16 177480.0 13400.0 0.5 0.4659 0.8842 3118589 ChemDiv3_007169 COc1cccc(c1)C(=O)NC(NCC2CCCO2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F20 compound treatment 13120.0 -154000.0 -5.98 13440.0 -151000.0 -5.65 -8.2257 -0.9996 1723594 ChemDiv3_007170 CCOC(=O)c1cnc2ccc(OCC)cc2c1N(C)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F21 compound treatment 193760.0 26500.0 1.03 160360.0 -3710.0 -0.14 0.6294 0.606 1579177 ChemDiv3_007171 OP(=O)(CN1CCCCC1)CN2CCCCCC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F22 compound treatment 169480.0 2250.0 0.09 183760.0 19700.0 0.74 0.5842 0.785 3118590 ChemDiv3_007172 CC1CN(CC(C)O1)S(=O)(=O)c2ccc(cc2)C(=O)/N=c\3/sc4cccc(Cl)c4n3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F23 mock treatment 207680.0 40400.0 1.57 161280.0 -2790.0 -0.1 1.0357 0.6585 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 F24 mock treatment 167200.0 -34.8 0.0 184320.0 20300.0 0.76 0.5366 0.7058 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G01 compound treatment 158160.0 -9070.0 -0.35 154720.0 -9350.0 -0.35 -0.497 -1.0 3026876 ChemDiv3_007173 COc1ccc(cc1OC)c2cc(nc(SCC(=O)N3CCCCCC3)n2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G02 compound treatment 10000.0 -157000.0 -6.1 10120.0 -154000.0 -5.78 -8.3995 -0.9996 3118591 ChemDiv3_007174 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NCCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G03 compound treatment 154840.0 -12400.0 -0.48 145240.0 -18800.0 -0.71 -0.8397 -0.9824 3026877 ChemDiv3_007175 CSc1ccccc1NC(=O)c2cnn3c(cc(nc23)c4ccco4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G04 compound treatment 140080.0 -27200.0 -1.05 184680.0 20600.0 0.77 -0.198 -0.1514 3118592 ChemDiv3_007176 CC1(C)CC(CCO1)N(Cc2cccs2)C(=O)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G05 compound treatment 25040.0 -142000.0 -5.52 31120.0 -133000.0 -4.99 -7.4295 -0.9987 3118593 ChemDiv3_007177 CCSC1=C(C#N)C(=O)NC(S1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G06 compound treatment 217200.0 50000.0 1.94 247040.0 83000.0 3.11 3.5729 0.974 3026878 ChemDiv3_007178 OC(=O)/C=C/c1ccc2c(onc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G07 compound treatment 158120.0 -9110.0 -0.35 155120.0 -8950.0 -0.34 -0.4875 -0.9997 3118594 ChemDiv3_007179 Cc1csc2nc(=O)c(nn12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G08 compound treatment 156520.0 -10700.0 -0.42 144440.0 -19600.0 -0.74 -0.8148 -0.9634 3026879 ChemDiv3_007180 CC(=O)NC1C(=O)Nc2c1cccc2C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G09 compound treatment 143880.0 -23400.0 -0.91 145360.0 -18700.0 -0.7 -1.1372 -0.992 3118595 ChemDiv3_007181 Cc1cccc(NC(=O)C2Sc3nnc(c4ccccc4)n3NC2c5ccccc5)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G10 compound treatment 156520.0 -10700.0 -0.42 168160.0 4090.0 0.15 -0.1853 -0.4181 3118596 ChemDiv3_007182 CCC(=O)N1CCNC(=O)C1CC(=O)Nc2ccc(C)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G11 compound treatment 178880.0 11600.0 0.45 172040.0 7970.0 0.3 0.5311 0.98 1170868 ChemDiv3_007183 Cn1c(=O)c(Nc2ccccc2)c3-c4ccccc4C(=O)c5cccc1c53 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G12 compound treatment 189000.0 21800.0 0.84 157520.0 -6550.0 -0.25 0.4234 0.4814 3026880 ChemDiv3_007184 CCc1nnc2sc(nn12)c3ccc(N)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G13 compound treatment 206760.0 39500.0 1.53 150680.0 -13400.0 -0.5 0.7292 0.4518 3118721 ChemDiv3_007185 CC(C)(CO)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G14 compound treatment 158560.0 -8670.0 -0.34 144120.0 -19900.0 -0.75 -0.7674 -0.9349 3118722 ChemDiv3_007186 Cn1cccc1CNCCc2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G15 compound treatment 192120.0 24900.0 0.97 173160.0 9090.0 0.34 0.9241 0.9023 3026881 ChemDiv3_007187 Oc1cccnc1NC(=O)CCC2COc3ccccc3O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G16 compound treatment 153960.0 -13300.0 -0.52 136640.0 -27400.0 -1.03 -1.0921 -0.9488 3118723 ChemDiv3_007188 CC1CN(CC(C)O1)c2nc3ccccc3nc2SCC(=O)NCc4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G17 compound treatment 132840.0 -34400.0 -1.33 131200.0 -32900.0 -1.23 -1.8159 -0.9992 3118724 ChemDiv3_007189 Cc1ccc(NC(=O)c2ccc(CSc3ncnc4[nH]cnc34)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G18 compound treatment 163120.0 -4110.0 -0.16 140880.0 -23200.0 -0.87 -0.7282 -0.8231 3026882 ChemDiv3_007190 CCOC(=O)c1cnc(Nc2nc3ccccc3s2)nc1CSc4ncccn4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G19 compound treatment 156560.0 -10700.0 -0.41 165080.0 1010.0 0.04 -0.266 -0.6395 3118725 ChemDiv3_007191 CC(C1SC(=O)NC1=O)C(=O)Nc2nccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G20 compound treatment 147840.0 -19400.0 -0.75 190680.0 26600.0 1.0 0.1742 0.1393 3026883 ChemDiv3_007192 FC(F)(F)C1(N=C(NC(=N1)c2ccccc2)c3ccccc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G21 compound treatment 148440.0 -18800.0 -0.73 146440.0 -17600.0 -0.66 -0.9834 -0.9988 3026933 ChemDiv3_007193 NC(=O)c1cc(C(=O)Nc2ccccc2)c(N)nc1SCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G22 compound treatment 82000.0 -85200.0 -3.31 40440.0 -124000.0 -4.64 -5.6194 -0.9862 3118726 ChemDiv3_007194 CC1=C(C#N)C(N=C(N1)C2CCCCC2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G23 mock treatment 152160.0 -15100.0 -0.58 156760.0 -7310.0 -0.27 -0.6075 -0.9404 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 G24 mock treatment 162600.0 -4630.0 -0.18 173320.0 9250.0 0.35 0.1184 0.3028 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H01 compound treatment 6880.0 -160000.0 -6.22 6920.0 -157000.0 -5.9 -8.57 -0.9996 1322971 ChemDiv3_007195 CC(C)c1ccc(cc1)C(Nc2nccs2)c3c(C)[nH]c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H02 compound treatment 152120.0 -15100.0 -0.59 175520.0 11500.0 0.43 -0.1107 -0.1523 3118727 ChemDiv3_007196 Cc1ccc(cc1)N(CC(=O)NCc2ccco2)S(=O)(=O)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H03 compound treatment 182640.0 15400.0 0.6 178240.0 14200.0 0.53 0.7988 0.9983 1679882 ChemDiv3_007197 Cc1[nH]c2ccccc2c1C(O)c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H04 compound treatment 157480.0 -9750.0 -0.38 155760.0 -8310.0 -0.31 -0.4881 -0.9954 3118728 ChemDiv3_007198 COc1ccc(CN/C(=N\c2ccccc2)/SC3CC(=O)NC3=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H05 compound treatment 163520.0 -3710.0 -0.14 145160.0 -18900.0 -0.71 -0.6037 -0.8337 3118729 ChemDiv3_007199 Cc1sc2N(CN(Cc3ccco3)Cc2c1C)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H06 compound treatment 159240.0 -7990.0 -0.31 164000.0 -66.3 0.0 -0.2211 -0.7128 3026934 ChemDiv3_007200 CCN1C(=O)/C(=C\C=C\2/Sc3ccc(Cl)cc3N2C)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H07 compound treatment 183760.0 16500.0 0.64 168440.0 4370.0 0.16 0.5695 0.8604 3118730 ChemDiv3_007201 Cc1ccc2cc3CCN(c3nc2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H08 compound treatment 137840.0 -29400.0 -1.14 117720.0 -46300.0 -1.74 -2.0365 -0.9791 1574479 ChemDiv3_007202 O=C(CCSc1ccccc1)NC2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H09 compound treatment 194400.0 27200.0 1.05 178000.0 13900.0 0.52 1.1151 0.9477 3118731 ChemDiv3_007203 Cc1ccc2cc3CCN(c3nc2c1)c4ccc(cc4)C(=O)NCc5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H10 compound treatment 159240.0 -7990.0 -0.31 155280.0 -8790.0 -0.33 -0.4525 -0.9995 1738369 ChemDiv3_007204 CCC(NC(=O)c1cc(OC)c(OC)c(OC)c1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H11 compound treatment 159920.0 -7310.0 -0.28 162960.0 -1110.0 -0.04 -0.23 -0.802 3026935 ChemDiv3_007205 CCOC(=O)c1ccc2nc(nc(N3CC(C)OC(C)C3)c2c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H12 compound treatment 144840.0 -22400.0 -0.87 137480.0 -26600.0 -1.0 -1.32 -0.9976 1558178 ChemDiv3_007206 CCCCn1c(SCC(=O)OCC)nc2n(CCc3ccccc3)c(=S)sc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H13 compound treatment 181360.0 14100.0 0.55 143480.0 -20600.0 -0.77 -0.1588 -0.1676 3118732 ChemDiv3_007207 Cc1cc2OC(=C(C#N)C(c3ccccc3)c2c(=O)n1CCCn4ccnc4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H14 compound treatment 135280.0 -32000.0 -1.24 119560.0 -44500.0 -1.67 -2.0579 -0.9892 1230528 ChemDiv3_007208 COc1ccc(OC)c(c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)Nc4ccc(C)c(Cl)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H15 compound treatment 175240.0 8010.0 0.31 177840.0 13800.0 0.52 0.5852 0.9703 3118733 ChemDiv3_007209 N(c1ccccc1)c2ccc(nn2)n3ccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H16 compound treatment 159640.0 -7590.0 -0.29 159160.0 -4910.0 -0.18 -0.3386 -0.9744 3026936 ChemDiv3_007210 CC(C)c1ccc(NC(=O)c2coc(=O)c3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H17 compound treatment 180680.0 13400.0 0.52 191920.0 27900.0 1.05 1.1081 0.9484 3118734 ChemDiv3_007211 CC(C)c1ccc(C)c(OP2(=O)COc3ccccc3OC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H18 compound treatment 166240.0 -995.0 -0.04 149400.0 -14700.0 -0.55 -0.4165 -0.7548 3026937 ChemDiv3_007212 CCOC(=O)c1cnc2cc(ccc2c1N(C)Cc3ccccc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H19 compound treatment 131400.0 -35800.0 -1.39 144920.0 -19100.0 -0.72 -1.4913 -0.9528 3118735 ChemDiv3_007213 Cc1ccc(NC(=O)c2cccc(OC(=S)NCc3ccccc3)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H20 compound treatment 138080.0 -29200.0 -1.13 141240.0 -22800.0 -0.86 -1.4057 -0.9906 3118736 ChemDiv3_007214 CCOC(=O)c1cnc2ccc(OCC)cc2c1N3CCN(CC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H21 compound treatment 13120.0 -154000.0 -5.98 11240.0 -153000.0 -5.74 -8.2841 -0.9998 3026938 ChemDiv3_007215 Cc1ccccc1/N=C/c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H22 compound treatment 174480.0 7250.0 0.28 161600.0 -2470.0 -0.09 0.1333 0.4505 3118737 ChemDiv3_007216 CCn1/c(=N\C(=O)c2ccc(cc2)S(=O)(=O)N3CCCC3)/sc4c1ccc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H23 mock treatment 150440.0 -16800.0 -0.65 170120.0 6050.0 0.23 -0.3001 -0.4349 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 H24 mock treatment 162200.0 -5030.0 -0.2 167840.0 3770.0 0.14 -0.038 -0.1574 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I01 compound treatment 36400.0 -131000.0 -5.08 68960.0 -95100.0 -3.57 -6.1136 -0.9851 3026939 ChemDiv3_007217 COc1ccc(cc1OC)c2cc(nc(SCC(=O)N3CCc4ccccc34)n2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I02 compound treatment 8560.0 -159000.0 -6.16 8560.0 -156000.0 -5.84 -8.4804 -0.9996 3118738 ChemDiv3_007218 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NCCCn4ccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I03 compound treatment 151280.0 -16000.0 -0.62 154920.0 -9150.0 -0.34 -0.6805 -0.9613 3026940 ChemDiv3_007219 Cc1cc(nc(SCc2ccc(o2)C(=O)O)n1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I04 compound treatment 128200.0 -39000.0 -1.51 145960.0 -18100.0 -0.68 -1.5515 -0.9346 3118739 ChemDiv3_007220 COc1ccc(Br)cc1C(=O)N2Cc3cc(OC)c(OC)cc3C4(CCCC4)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I05 compound treatment 17240.0 -150000.0 -5.82 20280.0 -144000.0 -5.4 -7.9312 -0.9993 3026941 ChemDiv3_007221 CCSC1=C(C#N)C(=O)NC(S1)c2ccc(OC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I06 compound treatment 141520.0 -25700.0 -1.0 150440.0 -13600.0 -0.51 -1.0671 -0.9518 3118740 ChemDiv3_007222 Clc1ccc(cc1)c2onc3cc(ccc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I07 compound treatment 43960.0 -123000.0 -4.78 22800.0 -141000.0 -5.3 -7.1312 -0.9987 3026942 ChemDiv3_007223 O=C/1Nc2ccccc2\C1=C\C=C\c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I08 compound treatment 151560.0 -15700.0 -0.61 154320.0 -9750.0 -0.37 -0.6887 -0.9704 3118741 ChemDiv3_007224 CCCn1c2ccc(C)cc2c3nnc(SCCN4CCOCC4)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I09 compound treatment 179160.0 11900.0 0.46 157680.0 -6390.0 -0.24 0.1577 0.3026 3118742 ChemDiv3_007225 O=C(C1Sc2nnc(c3ccccc3)n2NC1c4ccccc4)N5CCCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I10 compound treatment 198120.0 30900.0 1.2 152440.0 -11600.0 -0.44 0.5388 0.4225 3026943 ChemDiv3_007226 CCC(=O)N1C(CC(=O)Nc2ccc(F)cc2)C(=O)NC3CCCCC31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I11 compound treatment 122760.0 -44500.0 -1.73 119680.0 -44400.0 -1.67 -2.3982 -0.9998 1866671 ChemDiv3_007227 O=C1c2ccccc2-c3c(NCCc4ccccc4)c(=O)[nH]c5cccc1c35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I12 compound treatment 157080.0 -10200.0 -0.39 145160.0 -18900.0 -0.71 -0.7804 -0.9615 3118743 ChemDiv3_007228 COC(=O)C1=C(C)OC(=C(C#N)C1c2cc(C)cc(Cn3ccc(n3)C(F)(F)F)c2C)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I13 compound treatment 169880.0 2650.0 0.1 156680.0 -7390.0 -0.28 -0.1235 -0.4176 3026944 ChemDiv3_007229 Nc1cccc(c1)c2ccc(CO)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I14 compound treatment 172120.0 4890.0 0.19 148840.0 -15200.0 -0.57 -0.2701 -0.4485 3118744 ChemDiv3_007230 COc1ccc(CCNC(=O)CSc2nc3ccccc3nc2N4CCCC4)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I15 compound treatment 153680.0 -13600.0 -0.53 158480.0 -5590.0 -0.21 -0.5201 -0.9187 3026945 ChemDiv3_007231 NS(=O)(=O)c1ccc(NC(=O)CCC2COc3ccccc3O2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I16 compound treatment 173760.0 6530.0 0.25 158080.0 -5990.0 -0.22 0.0202 0.0595 1398603 ChemDiv3_007232 Nc1nonc1N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I17 compound treatment 143080.0 -24200.0 -0.94 141080.0 -23000.0 -0.86 -1.2727 -0.9991 3118745 ChemDiv3_007233 COc1ccc(OC)c(NC(=O)c2ccc(CSc3ncnc4[nH]cnc34)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I18 compound treatment 167480.0 245.0 0.01 177080.0 13000.0 0.49 0.3521 0.7207 3026838 ChemDiv3_007234 CC1CC(=O)c2cnc(nc2C1)N3CCc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I19 compound treatment 206120.0 38900.0 1.51 195280.0 31200.0 1.17 1.8952 0.9922 3118881 ChemDiv3_007235 COC(=O)c1ccc(CSc2nc(cc(n2)C(F)(F)F)c3cccs3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I20 compound treatment 164760.0 -2470.0 -0.1 153520.0 -10500.0 -0.4 -0.3478 -0.8539 3026840 ChemDiv3_007236 NC1=C(C#N)C(N=C2SCCN21)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I21 compound treatment 29520.0 -138000.0 -5.34 22960.0 -141000.0 -5.3 -7.5231 -1.0 3118882 ChemDiv3_007237 CCc1cc(C(N2CCN(CCO)CC2)c3ccc(Cl)cc3)c(NC(=O)c4ccccc4)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I22 compound treatment 153560.0 -13700.0 -0.53 177960.0 13900.0 0.52 -0.0065 -0.0087 3026842 ChemDiv3_007238 CCCCN1C(=NC(C2=C1CC(C)(C)CC2=O)(C(F)(F)F)C(F)(F)F)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I23 mock treatment 171880.0 4650.0 0.18 155840.0 -8230.0 -0.31 -0.0909 -0.2542 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 I24 mock treatment 163280.0 -3950.0 -0.15 176160.0 12100.0 0.45 0.2125 0.4434 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J01 compound treatment 30800.0 -136000.0 -5.29 39240.0 -125000.0 -4.68 -7.056 -0.9981 3026843 ChemDiv3_007239 Oc1ccc(CNc2cccc(c2)C(F)(F)F)c3cccnc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J02 compound treatment 114920.0 -52300.0 -2.03 144840.0 -19200.0 -0.72 -1.9455 -0.9031 3118883 ChemDiv3_007240 Oc1ccc(Cl)cc1/C=N/c2ccc3nc(SCC=C)sc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J03 compound treatment 11640.0 -156000.0 -6.04 10160.0 -154000.0 -5.78 -8.3534 -0.9998 1273454 ChemDiv3_007241 COc1ccc(cc1)C(N2CCOCC2)c3ccc4cccnc4c3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J04 compound treatment 208800.0 41600.0 1.61 175280.0 11200.0 0.42 1.438 0.8627 3026846 ChemDiv3_007242 O=C1CCCC(=O)C1=CNc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J05 compound treatment 153400.0 -13800.0 -0.54 150640.0 -13400.0 -0.5 -0.7359 -0.9995 3118884 ChemDiv3_007243 Cc1cccc(C)c1OCc2nnc(CCc3ccccc3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J06 compound treatment 138200.0 -29000.0 -1.13 146200.0 -17900.0 -0.67 -1.2707 -0.9693 1651075 ChemDiv3_007244 O=C1N(N=C2CCCCCC2)C(Nc3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J07 compound treatment 23000.0 -144000.0 -5.6 21600.0 -142000.0 -5.35 -7.7381 -0.9997 3118885 ChemDiv3_007245 FC(F)(F)c1c(C#N)c(SCc2ccccc2Cl)nc3-c4ccoc4CCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J08 compound treatment 151960.0 -15300.0 -0.59 153960.0 -10100.0 -0.38 -0.6873 -0.9767 1275637 ChemDiv3_007246 Fc1ccccc1C(=O)NCC(=O)NCc2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J09 compound treatment 149440.0 -17800.0 -0.69 136360.0 -27700.0 -1.04 -1.2235 -0.9802 3026850 ChemDiv3_007247 CC12CNC3(CO)CC2CCC13C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J10 compound treatment 162520.0 -4710.0 -0.18 155200.0 -8870.0 -0.33 -0.3647 -0.9603 3118886 ChemDiv3_007248 O=C(CSc1nnc(c2cccnc2)n1c3ccccc3)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J11 compound treatment 156400.0 -10800.0 -0.42 136280.0 -27800.0 -1.04 -1.0347 -0.9202 3026852 ChemDiv3_007249 CCOC(=O)c1ccc2nc(nc(N3CCCCC3)c2c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J12 compound treatment 177160.0 9930.0 0.39 172400.0 8330.0 0.31 0.4935 0.9947 1632505 ChemDiv3_007250 COc1ccc(NC(=O)c2ccc3c(=O)n(Cc4ccco4)c(=S)[nH]c3c2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J13 compound treatment 184440.0 17200.0 0.67 161760.0 -2310.0 -0.09 0.4108 0.6103 3118887 ChemDiv3_007251 Cc1cc2OC(=C(C#N)C(c3cccs3)c2c(=O)n1CC4CCCO4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J14 compound treatment 171680.0 4450.0 0.17 154120.0 -9950.0 -0.37 -0.142 -0.3453 1147245 ChemDiv3_007252 COc1ccc(OC)c(c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)N4CCC(CC4)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J15 compound treatment 168200.0 965.0 0.04 158120.0 -5950.0 -0.22 -0.1313 -0.5803 3026904 ChemDiv3_007253 Oc1ccc(Nc2nc(N3CCOCC3)c4ccccc4n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J16 compound treatment 215680.0 48400.0 1.88 185600.0 21500.0 0.81 1.9006 0.9289 3118888 ChemDiv3_007254 Fc1ccc(cc1)N2CCN(CC2)C(=O)CCNC(=O)Cn3cnc4sc5CCCCc5c4c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J17 compound treatment 172240.0 5010.0 0.19 157000.0 -7070.0 -0.27 -0.0502 -0.1527 3026906 ChemDiv3_007255 COC(=O)c1ccc(OP2(=O)COc3ccccc3OC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J18 compound treatment 81600.0 -85600.0 -3.32 51560.0 -113000.0 -4.22 -5.3353 -0.993 3026908 ChemDiv3_007256 CCOC(=O)c1cnc2cc(ccc2c1N3CCCCCC3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J19 compound treatment 181240.0 14000.0 0.54 161840.0 -2230.0 -0.08 0.3252 0.5914 3118889 ChemDiv3_007257 Oc1cccc(NC=C2C(=O)NC(=S)NC2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J20 compound treatment 156480.0 -10800.0 -0.42 155000.0 -9070.0 -0.34 -0.5357 -0.9949 1384020 ChemDiv3_007258 O=C(N(C1CCCCC1)c2ccccc2)c3cnc4SCCn4c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J21 compound treatment 182000.0 14800.0 0.57 170120.0 6050.0 0.23 0.5658 0.918 3026911 ChemDiv3_007259 CSc1nc(=O)c(Cc2ccccc2)n[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J22 compound treatment 28200.0 -139000.0 -5.39 22320.0 -142000.0 -5.32 -7.5763 -1.0 1518725 ChemDiv3_007260 COc1ccc(cc1)C(=O)NCCn2cc(SC(C)c3ccccc3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J23 mock treatment 173480.0 6250.0 0.24 145120.0 -18900.0 -0.71 -0.3315 -0.4412 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 J24 mock treatment 172200.0 4970.0 0.19 164920.0 854.0 0.03 0.1589 0.8135 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K01 compound treatment 164160.0 -3070.0 -0.12 149240.0 -14800.0 -0.56 -0.4778 -0.8396 1788828 ChemDiv3_007261 O=C(N1CCc2ccccc2C1)c3nc4ncccn4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K02 compound treatment 162920.0 -4310.0 -0.17 137200.0 -26900.0 -1.01 -0.8314 -0.8134 3118890 ChemDiv3_007262 CC(=O)Oc1cc2c(C(=O)N3CCCC3)c(C)oc2c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K03 compound treatment 148240.0 -19000.0 -0.74 155360.0 -8710.0 -0.33 -0.7522 -0.933 3026914 ChemDiv3_007263 CCOC(=O)c1cnn2c(cc(C)nc12)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K04 compound treatment 167640.0 405.0 0.02 190880.0 26800.0 1.01 0.7227 0.7181 3118891 ChemDiv3_007264 Nc1ccc2[nH]c(CCC(=O)O)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K05 compound treatment 121280.0 -46000.0 -1.78 126960.0 -37100.0 -1.39 -2.2456 -0.9925 1026774 ChemDiv3_007265 COc1ccc(cc1)[n+]2cc(O)on2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K06 compound treatment 167680.0 445.0 0.02 184920.0 20900.0 0.78 0.5657 0.7225 3118892 ChemDiv3_007266 Cc1cc2C(=O)C(=C(C(=O)c2cc1C)c3ccccc3)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K07 compound treatment 15080.0 -152000.0 -5.9 13240.0 -151000.0 -5.66 -8.1773 -0.9998 3026917 ChemDiv3_007267 CCc1cccc2c(c[nH]c12)C(C(=O)c3ccccc3)c4c[nH]c5c(CC)cccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K08 compound treatment 167080.0 -155.0 -0.01 153880.0 -10200.0 -0.38 -0.2746 -0.7181 3118893 ChemDiv3_007268 OCC1CCCN1CC2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K09 compound treatment 167160.0 -74.8 0.0 174280.0 10200.0 0.38 0.269 0.7017 3118894 ChemDiv3_007269 CC(C)CNC(=O)C1Sc2nnc(c3ccccc3)n2NC1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K10 compound treatment 176600.0 9370.0 0.36 163080.0 -986.0 -0.04 0.2308 0.6318 3026967 ChemDiv3_007270 Cn1c(=O)n(C)c2nc(ncc2c1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K11 compound treatment 118160.0 -49100.0 -1.9 123880.0 -40200.0 -1.51 -2.4129 -0.9933 1131768 ChemDiv3_007271 CC(=O)Nc1ccc(Nc2c3-c4ccccc4C(=O)c5cccc([nH]c2=O)c53)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K12 compound treatment 104280.0 -63000.0 -2.44 15400.0 -149000.0 -5.58 -5.6727 -0.9313 3026969 ChemDiv3_007272 CCOC(=O)C1=C(CSc2ccc(Cl)cc2)NC(=O)NC1c3cc(C)ccc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K13 compound treatment 180720.0 13500.0 0.52 162960.0 -1110.0 -0.04 0.3406 0.649 3118895 ChemDiv3_007273 O=C1/C(=C/Nc2ccccc2c3nc4ccccc4c(=O)o3)/Sc5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K14 compound treatment 163880.0 -3350.0 -0.13 156840.0 -7230.0 -0.27 -0.2838 -0.9434 3026972 ChemDiv3_007274 O=C(CSc1nc2ccccc2nc1N3CCCC3)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K15 compound treatment 165920.0 -1310.0 -0.05 153720.0 -10300.0 -0.39 -0.3107 -0.7932 3118896 ChemDiv3_007275 NS(=O)(=O)c1ccc(CCNC(=O)CCC2COc3ccccc3O2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K16 compound treatment 16680.0 -151000.0 -5.84 14120.0 -150000.0 -5.63 -8.11 -0.9998 3118897 ChemDiv3_007276 CCN(CC)CCn1c(=N)n(Cc2ccc(cc2)C(C)(C)C)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K17 compound treatment 188040.0 20800.0 0.81 163400.0 -666.0 -0.03 0.5531 0.6849 1582818 ChemDiv3_007277 CCC(=O)Nc1nonc1c2nc3ccccc3n2CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K18 compound treatment 170560.0 3330.0 0.13 166320.0 2250.0 0.08 0.151 0.979 3118898 ChemDiv3_007278 Cc1ccc(cc1)S(=O)(=O)NC2=NCN(CCN3CCOCC3)CN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K19 compound treatment 175560.0 8330.0 0.32 177160.0 13100.0 0.49 0.5759 0.9793 3026975 ChemDiv3_007279 Cc1ccc(o1)C(O)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K20 compound treatment 149720.0 -17500.0 -0.68 158640.0 -5430.0 -0.2 -0.6245 -0.8803 3118899 ChemDiv3_007280 Cc1ccc(cc1)C2=NC(N=C3SCCN32)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K21 compound treatment 143080.0 -24200.0 -0.94 132600.0 -31500.0 -1.18 -1.4978 -0.9934 3026978 ChemDiv3_007281 CCOC(=O)C1CCN(CC1)C(c2c(NC(=O)C)sc3CCCCc23)c4cccc(Cl)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K22 compound treatment 156400.0 -10800.0 -0.42 171480.0 7410.0 0.28 -0.1005 -0.1994 3118900 ChemDiv3_007282 CCCCN1C(=O)NC(C2=C1CC(C)(C)CC2=O)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K23 mock treatment 166040.0 -1190.0 -0.05 154080.0 -9990.0 -0.37 -0.2978 -0.7886 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 K24 mock treatment 167600.0 365.0 0.01 164440.0 374.0 0.01 0.0199 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L01 compound treatment 9600.0 -158000.0 -6.12 7680.0 -156000.0 -5.87 -8.4752 -0.9998 1446827 ChemDiv3_007283 COc1ccc(cc1)C(N2CCOCC2)c3c(C)[nH]c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L02 compound treatment 182000.0 14800.0 0.57 175960.0 11900.0 0.45 0.7207 0.9924 3026980 ChemDiv3_007284 COc1ccc(/C=N/N2C(=O)c3ccc4CCc5ccc(C2=O)c3c45)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L03 compound treatment 44960.0 -122000.0 -4.74 26960.0 -137000.0 -5.15 -6.9934 -0.9992 3119027 ChemDiv3_007285 CC(=O)Nc1cccc(c1)C2=Nc3ccccc3SC(C2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L04 compound treatment 143960.0 -23300.0 -0.9 148480.0 -15600.0 -0.58 -1.0522 -0.9779 1408100 ChemDiv3_007286 Clc1ccc(cc1)C(=O)c2ccc(cc2)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L05 compound treatment 162160.0 -5070.0 -0.2 163880.0 -186.0 -0.01 -0.1442 -0.7317 3027023 ChemDiv3_007287 COC(=O)CC1N(CCNC1=O)C(=O)OC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L06 compound treatment 152000.0 -15200.0 -0.59 155360.0 -8710.0 -0.33 -0.649 -0.9609 3119028 ChemDiv3_007288 COc1ccc(cc1)/C(=N/N2C(Nc3ccccc3C2=O)c4ccccc4O)/C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L07 compound treatment 89320.0 -77900.0 -3.02 78520.0 -85500.0 -3.21 -4.408 -0.9995 3119029 ChemDiv3_007289 COC(=O)c1ccccc1NC(=O)c2ccc(cc2)n3nc(c4CCc5occc5-c43)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L08 compound treatment 181240.0 14000.0 0.54 173800.0 9730.0 0.37 0.6426 0.9813 3027025 ChemDiv3_007290 Cc1cc2nc3s/c(=C/4\C(=O)N(CC(=O)O)c5ccccc45)/c(=O)n3c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L09 compound treatment 176200.0 8970.0 0.35 165880.0 1810.0 0.07 0.2941 0.8297 3119030 ChemDiv3_007291 Cc1ccc(NC(=O)c2ccc(cc2)n3nc(c4CCc5occc5-c43)C(F)(F)F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L10 compound treatment 169400.0 2170.0 0.08 154600.0 -9470.0 -0.36 -0.1918 -0.5254 3027027 ChemDiv3_007292 COC(=O)Nc1ccc(cc1)C(=O)NCC2CCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L11 compound treatment 158080.0 -9150.0 -0.36 148120.0 -15900.0 -0.6 -0.6744 -0.969 3119031 ChemDiv3_007293 CCOC(=O)c1ccc2nc(nc(NCc3ccc(Cl)cc3)c2c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L12 compound treatment 170040.0 2810.0 0.11 159240.0 -4830.0 -0.18 -0.0511 -0.2419 1631642 ChemDiv3_007294 CCOC(=O)N1CCN(CC1)C(=O)c2ccc3c(=O)n(CC4CCCO4)c(=S)[nH]c3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L13 compound treatment 175080.0 7850.0 0.3 155760.0 -8310.0 -0.31 -0.0052 -0.0119 3119032 ChemDiv3_007295 Cc1cc(O)cc(=O)n1Cc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L14 compound treatment 173680.0 6450.0 0.25 157800.0 -6270.0 -0.24 0.0105 0.0307 1665168 ChemDiv3_007296 COc1ccc(c(OC)c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)NC4CCCC(C)C4C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L15 compound treatment 188440.0 21200.0 0.82 122920.0 -41100.0 -1.54 -0.5102 -0.2916 3027031 ChemDiv3_007297 C1CCN(CC1)c2ncnc3c4ccccc4oc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L16 compound treatment 168040.0 805.0 0.03 146480.0 -17600.0 -0.66 -0.4446 -0.6729 1122672 ChemDiv3_007298 COc1ccc(cc1)C2C3=C(CC(C)(C)CC3=O)N(C)C4=C2C(=O)CC(C)(C)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L17 compound treatment 177880.0 10600.0 0.41 173200.0 9130.0 0.34 0.5345 0.9957 3027033 ChemDiv3_007299 Clc1ccc2nc(NP3(=O)COc4ccccc4O3)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L18 compound treatment 94400.0 -72800.0 -2.83 80160.0 -83900.0 -3.15 -4.2251 -0.9985 3119033 ChemDiv3_007300 CCOC(=O)c1cnc2cc(ccc2c1N3CC(C)CC(C)C3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L19 compound treatment 191880.0 24600.0 0.96 157360.0 -6710.0 -0.25 0.4982 0.5038 3027035 ChemDiv3_007301 CCC1(CC)C(=O)N(CC(=O)OC)C(=O)N(C)C1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L20 compound treatment 155240.0 -12000.0 -0.47 159360.0 -4710.0 -0.18 -0.454 -0.912 1630796 ChemDiv3_007302 COc1cccc2sc(NC(=O)c3ccc(cc3)S(=O)(=O)N(C)C)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L21 compound treatment 165520.0 -1710.0 -0.07 162040.0 -2030.0 -0.08 -0.1008 -0.9978 3119034 ChemDiv3_007303 COC(=O)c1ccc(/C=N/c2ccc3oc(nc3c2)c4ccc(C)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L22 compound treatment 142200.0 -25000.0 -0.97 129440.0 -34600.0 -1.3 -1.6058 -0.9897 1710843 ChemDiv3_007304 COc1ccc(cc1)C(=O)NCCn2cc(SCC(=O)Nc3ccccc3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L23 mock treatment 153680.0 -13600.0 -0.53 171320.0 7250.0 0.27 -0.1794 -0.3029 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 L24 mock treatment 175680.0 8450.0 0.33 171520.0 7450.0 0.28 0.4295 0.9969 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M01 compound treatment 158320.0 -8910.0 -0.35 170520.0 6450.0 0.24 -0.0733 -0.1736 1183622 ChemDiv3_007305 O=C(NCc1ccccc1)c2nc3ncccn3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M02 compound treatment 134080.0 -33200.0 -1.29 149000.0 -15100.0 -0.57 -1.3095 -0.9319 3119035 ChemDiv3_007306 COc1ccc(CNC(=O)c2c(C)oc3c2cc(OC(=O)C)c4ccccc34)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M03 compound treatment 154160.0 -13100.0 -0.51 157600.0 -6470.0 -0.24 -0.5303 -0.943 3027121 ChemDiv3_007307 COc1cccc(c1)C2CC(n3ncc(C(=O)O)c3N2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M04 compound treatment 162600.0 -4630.0 -0.18 177840.0 13800.0 0.52 0.2384 0.4355 3119036 ChemDiv3_007308 Cc1ccc2[nH]c(CCCC(=O)O)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M05 compound treatment 167720.0 485.0 0.02 162520.0 -1550.0 -0.06 -0.0277 -0.4544 3027123 ChemDiv3_007309 CCSC1=C(C#N)C(=O)NC(S1)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M06 compound treatment 160840.0 -6390.0 -0.25 179000.0 14900.0 0.56 0.2209 0.3603 3119037 ChemDiv3_007310 O=C(Nc1ccccc1)C2CC(=O)n3ncnc3N2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M07 compound treatment 159880.0 -7350.0 -0.29 146800.0 -17300.0 -0.65 -0.66 -0.9321 1057220 ChemDiv3_007311 OC(COc1ccccc1)Cn2ccccc2=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M08 compound treatment 151320.0 -15900.0 -0.62 171320.0 7250.0 0.27 -0.2441 -0.3618 3027125 ChemDiv3_007312 CC(=O)Nc1cccc(c1)c2nn3c(C)nnc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M09 compound treatment 205080.0 37800.0 1.47 186120.0 22100.0 0.83 1.6236 0.9632 3119038 ChemDiv3_007313 Fc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)NCc4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M10 compound treatment 169720.0 2490.0 0.1 183400.0 19300.0 0.73 0.5813 0.7941 3027127 ChemDiv3_007314 COC(=O)c1c(C)ncc2COC(C)OCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M11 compound treatment 17080.0 -150000.0 -5.83 12640.0 -151000.0 -5.68 -8.1383 -0.9999 3119039 ChemDiv3_007315 Oc1c(Sc2cccc3cccnc23)cc(NS(=O)(=O)c4ccc(Cl)cc4)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M12 compound treatment 182000.0 14800.0 0.57 164960.0 894.0 0.03 0.4288 0.7472 3027129 ChemDiv3_007316 O=C(CSc1ccccn1)N2CCN(C2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M13 compound treatment 169200.0 1970.0 0.08 170600.0 6530.0 0.25 0.2273 0.8852 3119040 ChemDiv3_007317 CN(C)CCNC(=O)c1cc2ccccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M14 compound treatment 135160.0 -32100.0 -1.24 138760.0 -25300.0 -0.95 -1.5516 -0.9911 3119041 ChemDiv3_007318 CC1CN(CC(C)O1)c2nc3ccccc3nc2SCC(=O)NCCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M15 compound treatment 153360.0 -13900.0 -0.54 151480.0 -12600.0 -0.47 -0.7147 -0.9979 3027131 ChemDiv3_007319 COCCn1c(nc(=S)c2COC(C)(C)Cc21)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M16 compound treatment 155240.0 -12000.0 -0.47 142280.0 -21800.0 -0.82 -0.9073 -0.9643 3027133 ChemDiv3_007320 Cn1c(=N)n(CCCOc2ccc(F)cc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M17 compound treatment 155400.0 -11800.0 -0.46 142400.0 -21700.0 -0.81 -0.8997 -0.9634 3119042 ChemDiv3_007321 Cc1ccn2cc(cc2c1)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M18 compound treatment 169720.0 2490.0 0.1 142440.0 -21600.0 -0.81 -0.5058 -0.6188 3119043 ChemDiv3_007322 Cc1ccc2C(=O)NC(Nc2c1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M19 compound treatment 174080.0 6850.0 0.27 177600.0 13500.0 0.51 0.547 0.9543 3027207 ChemDiv3_007323 CCOC(=O)c1ccc(Nc2nnc3n(CC=C)c(=O)c4c(C)c(C)sc4n23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M20 compound treatment 140960.0 -26300.0 -1.02 150760.0 -13300.0 -0.5 -1.074 -0.9461 3119044 ChemDiv3_007324 CC1=C(C#N)C(N=C(N1)c2ccncc2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M21 compound treatment 13120.0 -154000.0 -5.98 10840.0 -153000.0 -5.75 -8.2947 -0.9998 3027209 ChemDiv3_007325 CC1CCN(CC1)C(=O)c2c(C)oc3C(=O)c4ccccc4C(=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M22 compound treatment 126840.0 -40400.0 -1.57 125680.0 -38400.0 -1.44 -2.127 -0.9991 3119045 ChemDiv3_007326 CC1=C(C#N)C(N=C(Cc2ccccc2)N1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M23 mock treatment 169360.0 2130.0 0.08 153320.0 -10700.0 -0.4 -0.2269 -0.5511 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 M24 mock treatment 171240.0 4010.0 0.16 153040.0 -11000.0 -0.41 -0.1827 -0.4134 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N01 compound treatment 128840.0 -38400.0 -1.49 122640.0 -41400.0 -1.55 -2.1528 -0.9998 1651520 ChemDiv3_007327 COc1ccc(cc1)C(OC(=O)c2ccccc2)c3nccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N02 compound treatment 179520.0 12300.0 0.48 161960.0 -2110.0 -0.08 0.2812 0.5819 1505116 ChemDiv3_007328 Cc1ccc(NC(=O)c2cc(=O)[nH]c(=O)[nH]2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N03 compound treatment 170000.0 2770.0 0.11 158400.0 -5670.0 -0.21 -0.0745 -0.3128 3119046 ChemDiv3_007329 CC(=O)N1CN(Cc2c3CCCCc3sc12)C4CCS(=O)(=O)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N04 compound treatment 163720.0 -3510.0 -0.14 143040.0 -21000.0 -0.79 -0.6544 -0.8172 1135097 ChemDiv3_007330 CCN(CC)S(=O)(=O)c1ccc(Cl)c(c1)C(=O)Oc2ccc(C)c(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N05 compound treatment 62440.0 -105000.0 -4.07 50280.0 -114000.0 -4.27 -5.8949 -0.9997 3119047 ChemDiv3_007331 Oc1ccc(NC(=O)CN2CC(=O)Oc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N06 compound treatment 181360.0 14100.0 0.55 176440.0 12400.0 0.46 0.7159 0.9966 3027214 ChemDiv3_007332 CCOC(=O)C1=C(NC(=S)NC1CC)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N07 compound treatment 122240.0 -45000.0 -1.75 86160.0 -77900.0 -2.92 -3.302 -0.9696 3119048 ChemDiv3_007333 CC(C)(C)NC(=O)c1ccc(cc1)n2nc(c3CCc4occc4-c32)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N08 compound treatment 175320.0 8090.0 0.31 139080.0 -25000.0 -0.94 -0.4413 -0.4463 3119179 ChemDiv3_007334 CCc1nnc(NC(=O)CSc2nc(cc(c2C#N)C(F)(F)F)c3ccccc3)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N09 compound treatment 228800.0 61600.0 2.39 189000.0 24900.0 0.94 2.3508 0.9163 3027218 ChemDiv3_007335 OC(=O)c1nn(c-2c1CCc3occc32)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N10 compound treatment 156760.0 -10500.0 -0.41 140880.0 -23200.0 -0.87 -0.9027 -0.9399 3119180 ChemDiv3_007336 COc1ccc(NC(=C2C(=O)CC(C)(C)CC2=O)CCCN3C(=O)c4ccccc4C3=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N11 compound treatment 161800.0 -5430.0 -0.21 152000.0 -12100.0 -0.45 -0.4693 -0.9395 3027294 ChemDiv3_007337 CCOC(=O)c1ccc2nc(nc(NCCc3ccc(OC)cc3)c2c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N12 compound treatment 156880.0 -10400.0 -0.4 158720.0 -5350.0 -0.2 -0.426 -0.9485 1740813 ChemDiv3_007338 COc1ccc(cc1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)N4CCN(CC4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N13 compound treatment 151920.0 -15300.0 -0.59 148360.0 -15700.0 -0.59 -0.837 -1.0 3027297 ChemDiv3_007339 COc1ccc(Cn2c(C)cc(O)cc2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N14 compound treatment 28400.0 -139000.0 -5.39 76160.0 -87900.0 -3.3 -6.142 -0.9723 1296230 ChemDiv3_007340 Cc1ccc(NC(=O)c2ccc3c(=O)n(Cc4ccco4)c(=S)[nH]c3c2)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N15 compound treatment 163160.0 -4070.0 -0.16 160840.0 -3230.0 -0.12 -0.1974 -0.9913 3027299 ChemDiv3_007341 OCn1c2CCCCc2c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N16 compound treatment 139960.0 -27300.0 -1.06 104240.0 -59800.0 -2.25 -2.336 -0.9411 3119181 ChemDiv3_007342 Cc1ccc(cc1C)N2C3=C(C(C4=C2CC(C)(C)CC4=O)c5cccs5)C(=O)CC(C)(C)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N17 compound treatment 166360.0 -875.0 -0.03 152280.0 -11800.0 -0.44 -0.3368 -0.7591 3027303 ChemDiv3_007343 Brc1ccc(cc1)C(=O)C(C(=O)N2CCCCC2)n3ccccc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N18 compound treatment 15360.0 -152000.0 -5.89 11400.0 -153000.0 -5.73 -8.2184 -0.9999 3119182 ChemDiv3_007344 CCOC(=O)c1cnc2c(OC)cccc2c1NC3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N19 compound treatment 183160.0 15900.0 0.62 146880.0 -17200.0 -0.65 -0.0192 -0.0215 3027305 ChemDiv3_007345 CCOc1ccc(/C=N/n2c(C)nc3ccccc3c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N20 compound treatment 154280.0 -13000.0 -0.5 118600.0 -45500.0 -1.71 -1.5621 -0.8781 1741518 ChemDiv3_007346 COc1cccc2sc(NC(=O)c3ccc(cc3)S(=O)(=O)N4CCCC(C)C4)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N21 compound treatment 158640.0 -8590.0 -0.33 160680.0 -3390.0 -0.13 -0.3257 -0.9126 3027307 ChemDiv3_007347 COc1cc(/C=N/c2ccc(C)cc2)ccc1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N22 compound treatment 135320.0 -31900.0 -1.24 131760.0 -32300.0 -1.21 -1.733 -0.9999 1286138 ChemDiv3_007348 COc1ccc(cc1)C(=O)NCCn2cc(SCC(=O)N3CCCCC3)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N23 mock treatment 148240.0 -19000.0 -0.74 172280.0 8210.0 0.31 -0.3032 -0.3795 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 N24 mock treatment 158080.0 -9150.0 -0.36 162720.0 -1350.0 -0.05 -0.2869 -0.7996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O01 compound treatment 172440.0 5210.0 0.2 167200.0 3130.0 0.12 0.226 0.9669 1788832 ChemDiv3_007349 O=C(N(Cc1ccccc1)Cc2ccccc2)c3nc4ncccn4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O02 compound treatment 167120.0 -115.0 0.0 167560.0 3490.0 0.13 0.0896 0.6827 3119183 ChemDiv3_007350 COc1ccc(cc1)N(C(=O)c2ccccc2)S(=O)(=O)c3cccc4cccnc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O03 compound treatment 150920.0 -16300.0 -0.63 167720.0 3650.0 0.14 -0.3506 -0.5414 3027446 ChemDiv3_007351 COc1ccc2nc3C(=O)c4ccccc4C(=O)c3nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O04 compound treatment 178760.0 11500.0 0.45 173600.0 9530.0 0.36 0.5692 0.9939 3119184 ChemDiv3_007352 OC(=O)c1ccc2[nH]c(CCc3nc4cc(ccc4[nH]3)C(=O)O)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O05 compound treatment 183960.0 16700.0 0.65 167880.0 3810.0 0.14 0.5601 0.8428 3027447 ChemDiv3_007353 CCSC1=C(C#N)C(=O)NCS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O06 compound treatment 13280.0 -154000.0 -5.97 9400.0 -155000.0 -5.8 -8.3286 -0.9999 3119185 ChemDiv3_007354 Clc1ccccc1C2N=C(Nc3nc4ccccc4s3)NC5=C2C(=O)CCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O07 compound treatment 196080.0 28800.0 1.12 88000.0 -76100.0 -2.85 -1.2273 -0.4002 3027478 ChemDiv3_007355 COc1ccc(cc1)C2=Cc3ccccc3C(C)(C)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O08 compound treatment 184040.0 16800.0 0.65 162200.0 -1870.0 -0.07 0.4115 0.6275 3119186 ChemDiv3_007356 CC1(C)CC(=O)C2=C(C1)NCN(Cc3ccc4OCOc4c3)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O09 compound treatment 143120.0 -24100.0 -0.94 119760.0 -44300.0 -1.66 -1.8375 -0.963 3119187 ChemDiv3_007357 Fc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)Nc4ccccc4C(F)(F)F)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O10 compound treatment 174160.0 6930.0 0.27 164280.0 214.0 0.01 0.1957 0.7279 3027482 ChemDiv3_007358 CCCC[N+]1(C)C2CCC1CC(O)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O11 compound treatment 167120.0 -115.0 0.0 169600.0 5530.0 0.21 0.1437 0.6918 3027483 ChemDiv3_007359 OCCNS(=O)(=O)c1cccc2cccnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O12 compound treatment 158720.0 -8510.0 -0.33 153760.0 -10300.0 -0.39 -0.5071 -0.9969 3119188 ChemDiv3_007360 Cc1ccc2oc(c(CN3CCOCC3)c(=O)c2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O13 compound treatment 180920.0 13700.0 0.53 166080.0 2010.0 0.08 0.4289 0.7997 3027487 ChemDiv3_007361 CCCN1CC2CCCC3(C1)C(=O)NC4(CCCCC4)N=C23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O14 compound treatment 146320.0 -20900.0 -0.81 131080.0 -33000.0 -1.24 -1.4492 -0.979 3119189 ChemDiv3_007362 CC1CN(CC(C)O1)c2nc3ccccc3nc2SCC(=O)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O15 compound treatment 171400.0 4170.0 0.16 164840.0 774.0 0.03 0.1348 0.821 3119190 ChemDiv3_007363 Sc1ncnc2c1sc3nc(N4CCOCC4)c5CCCCc5c32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O16 compound treatment 78920.0 -88300.0 -3.43 62520.0 -102000.0 -3.81 -5.1179 -0.9986 3027489 ChemDiv3_007364 CCn1c(=N)n(CCCOc2ccc(Br)cc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O17 compound treatment 147920.0 -19300.0 -0.75 148600.0 -15500.0 -0.58 -0.9404 -0.992 3119191 ChemDiv3_007365 COc1cccc(CN2c3cccc4cccc(c34)S2(=O)=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O18 compound treatment 172960.0 5730.0 0.22 144240.0 -19800.0 -0.74 -0.3691 -0.4753 3027491 ChemDiv3_007366 CN(C)C1=NC(N=C(C)O1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O19 compound treatment 204000.0 36800.0 1.43 179600.0 15500.0 0.58 1.4209 0.9221 3119192 ChemDiv3_007367 CN(CCO)C(=O)c1ccc-2c(c1)C(=O)c3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O20 compound treatment 151160.0 -16100.0 -0.62 151960.0 -12100.0 -0.45 -0.7623 -0.9879 3027493 ChemDiv3_007368 FC(F)(F)C1(C2CC(C=C2)N1C(=O)c3ccncc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O21 compound treatment 11520.0 -156000.0 -6.04 9840.0 -154000.0 -5.79 -8.3652 -0.9998 3119193 ChemDiv3_007369 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)N4CCc5ccccc5C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O22 compound treatment 18720.0 -149000.0 -5.76 40440.0 -124000.0 -4.64 -7.3556 -0.9942 1582951 ChemDiv3_007370 CCN1CCN(CC1)C(c2cccnc2)c3ccc4cccnc4c3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O23 mock treatment 157560.0 -9670.0 -0.38 169920.0 5850.0 0.22 -0.1101 -0.2531 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 O24 mock treatment 177520.0 10300.0 0.4 180560.0 16500.0 0.62 0.7199 0.9774 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P01 compound treatment 6960.0 -160000.0 -6.22 6000.0 -158000.0 -5.93 -8.5922 -0.9997 1619302 ChemDiv3_007371 Cc1[nH]c2ccccc2c1C(Nc3cc(C)ccn3)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P02 compound treatment 162640.0 -4590.0 -0.18 169440.0 5370.0 0.2 0.0166 0.0615 3119194 ChemDiv3_007372 Cc1ccc2NC(C3CC=CC3c2c1)c4ccc(/N=C/c5ccccc5)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P03 compound treatment 168680.0 1450.0 0.06 154240.0 -9830.0 -0.37 -0.2211 -0.5928 3027529 ChemDiv3_007373 CC(=O)N1CN(CCCn2ccnc2)Cc3c4CCCCc4sc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P04 compound treatment 146320.0 -20900.0 -0.81 122160.0 -41900.0 -1.57 -1.686 -0.9526 3027531 ChemDiv3_007374 O=S(=O)(Nc1ccccc1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P05 compound treatment 127080.0 -40200.0 -1.56 115920.0 -48100.0 -1.81 -2.3794 -0.9973 3119195 ChemDiv3_007375 Fc1ccc(cc1)N2CCN(CC2)C(=O)CN3CC(=O)Oc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P06 compound treatment 10800.0 -156000.0 -6.07 6920.0 -157000.0 -5.9 -8.4624 -0.9999 1922912 ChemDiv3_007376 OC(CC(=O)/C=C/c1ccccc1)(c2ccccc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P07 compound treatment 183000.0 15800.0 0.61 162760.0 -1310.0 -0.05 0.3979 0.6484 3027533 ChemDiv3_007377 COC(=O)c1oc2CC(C)(C)c3nc4ccccc4nc3-c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P08 compound treatment 94000.0 -73200.0 -2.84 75280.0 -88800.0 -3.33 -4.3656 -0.9969 1600357 ChemDiv3_007378 CCc1ccc(cc1)N2NC(=O)C(=C(C)C)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P09 compound treatment 61600.0 -106000.0 -4.1 46840.0 -117000.0 -4.4 -6.0093 -0.9994 3119196 ChemDiv3_007379 Cc1ccc(Sc2sc(=O)n(C)c2S(=O)(=O)c3ccc(C)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P10 compound treatment 124320.0 -42900.0 -1.67 100000.0 -64100.0 -2.4 -2.8777 -0.9839 1389317 ChemDiv3_007380 S=C(NCCc1ccccc1)N2CCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P11 compound treatment 188760.0 21500.0 0.84 157720.0 -6350.0 -0.24 0.4221 0.4861 3119197 ChemDiv3_007381 Cc1cc2OC(=C(C#N)C(c3ccccc3)c2c(=O)n1Cc4ccccn4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P12 compound treatment 171560.0 4330.0 0.17 163440.0 -626.0 -0.02 0.102 0.6022 1520017 ChemDiv3_007382 O=C(NCC1CCCO1)c2ccc3c(=O)n(c4ccccc4)c(=S)[nH]c3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P13 compound treatment 145160.0 -22100.0 -0.86 202240.0 38200.0 1.43 0.4074 0.2441 3027536 ChemDiv3_007383 COc1ccc(CCn2c(C)cc(O)cc2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P14 compound treatment 148720.0 -18500.0 -0.72 145320.0 -18700.0 -0.7 -1.0055 -0.9999 1672880 ChemDiv3_007384 COc1ccc(CCNC(=O)c2ccc3c(=O)n(CC4CCCO4)c(=S)[nH]c3c2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P15 compound treatment 169920.0 2690.0 0.1 142240.0 -21800.0 -0.82 -0.5056 -0.6122 3027538 ChemDiv3_007385 O=C1CCC(=O)N1CCOP2(=O)COc3ccccc3OC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P16 compound treatment 156200.0 -11000.0 -0.43 150240.0 -13800.0 -0.52 -0.6697 -0.9954 3119321 ChemDiv3_007386 CCN(CC)CCN1C2=C(C(C3=C1CC(C)(C)CC3=O)c4cccc(F)c4)C(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P17 compound treatment 188360.0 21100.0 0.82 166880.0 2810.0 0.11 0.6543 0.7917 3027592 ChemDiv3_007387 Oc1ccccc1CNCc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P18 compound treatment 249520.0 82300.0 3.19 172240.0 8170.0 0.31 2.4745 0.7715 3119322 ChemDiv3_007388 CCOC(=O)c1cnc2c(OC)cccc2c1N3CCC4(CC3)OCCO4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P19 compound treatment 147120.0 -20100.0 -0.78 134960.0 -29100.0 -1.09 -1.3243 -0.9864 1582507 ChemDiv3_007389 CC(C)c1ccc(CNC(=O)CCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P20 compound treatment 153240.0 -14000.0 -0.54 166720.0 2650.0 0.1 -0.3135 -0.5679 3119323 ChemDiv3_007390 COC(=O)c1ccc2n(C)/c(=N\C(=O)c3ccc(cc3)S(=O)(=O)N4CCCCC4C)/sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P21 compound treatment 149960.0 -17300.0 -0.67 146880.0 -17200.0 -0.65 -0.9301 -0.9998 1257313 ChemDiv3_007391 O=C1N(CCSC(=S)N2CCSCC2)Cc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P22 compound treatment 150840.0 -16400.0 -0.64 137400.0 -26700.0 -1.0 -1.1575 -0.9761 1190401 ChemDiv3_007392 Cc1cccc(NC(=O)CSc2cn(CCNC(=O)c3ccc(F)cc3)c4ccccc24)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P23 mock treatment 212760.0 45500.0 1.77 166040.0 1970.0 0.07 1.3014 0.7361 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2021 P24 mock treatment 167600.0 365.0 0.01 154880.0 -9190.0 -0.34 -0.2338 -0.6775 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A01 compound treatment 197560.0 51600.0 2.0 188880.0 41100.0 1.54 2.5043 0.9917 3063199 Maybridge4_000353 O=C1CCc2cc(ccc2N1)C3=CSC4=NCCN34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A02 compound treatment 15600.0 -130000.0 -5.06 12800.0 -135000.0 -5.07 -7.1609 -1.0 3178435 Maybridge4_000354 CC1(C)OC(=O)C(C2C3CC4CC(C3)CC2C4)C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A03 compound treatment 182960.0 37000.0 1.43 182880.0 35100.0 1.32 1.9445 0.9991 3178436 Maybridge4_000355 Cc1nc(cs1)c2cc(C#N)c(SCCNC(=O)c3ccc(Cl)cc3Cl)nc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A04 compound treatment 103160.0 -42800.0 -1.66 101040.0 -46800.0 -1.76 -2.4168 -0.9996 1602887 Maybridge4_000356 CC1(C)Oc2c(C=C1)c3c(=O)cc(oc3c4ccoc24)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A05 compound treatment 174160.0 28200.0 1.09 165000.0 17200.0 0.65 1.2286 0.9684 3063200 Maybridge4_000357 COc1cc(OC)nc(/N=C/N(C)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A06 compound treatment 152800.0 6790.0 0.26 164640.0 16800.0 0.63 0.633 0.9249 3178437 Maybridge4_000358 CC1(C)CN=C(NC2CCCCC2)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A07 compound treatment 139440.0 -6570.0 -0.25 160400.0 12600.0 0.47 0.1539 0.2868 3178438 Maybridge4_000359 COc1ccc(CCC(=O)CCc2ccc(OC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A08 compound treatment 184120.0 38100.0 1.48 173720.0 25900.0 0.97 1.7333 0.9793 3063201 Maybridge4_000360 COc1ccccc1OC(=O)NC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A09 compound treatment 146680.0 674.0 0.03 168640.0 20800.0 0.78 0.5713 0.7303 3178439 Maybridge4_000361 CCOC(=O)c1ccc(cc1)C(=S)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A10 compound treatment 115880.0 -30100.0 -1.17 150240.0 2430.0 0.09 -0.7621 -0.65 1174208 Maybridge4_000362 CCC1(CCCCN(C)C1=O)c2cccc(OC(=O)C3CCCCC3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A11 compound treatment 166240.0 20200.0 0.79 156960.0 9150.0 0.34 0.7979 0.9312 3063202 Maybridge4_000363 CN(C)Cc1c(C)cc(C)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A12 compound treatment 92120.0 -53900.0 -2.09 103480.0 -44300.0 -1.66 -2.6549 -0.9936 1469863 Maybridge4_000364 O=C(Nc1nc(cs1)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A13 compound treatment 155440.0 9430.0 0.37 170040.0 22200.0 0.83 0.8488 0.9316 1002608 Maybridge4_000365 CCOC(=O)c1cnc(S)nc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A14 compound treatment 146600.0 594.0 0.02 168160.0 20300.0 0.76 0.5563 0.7281 1583969 Maybridge4_000366 Clc1cccc(c1)C(=O)NC2CN3CCC2CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A15 compound treatment 143400.0 -2610.0 -0.1 184200.0 36400.0 1.37 0.8942 0.653 3063203 Maybridge4_000367 COc1cc(C#N)c2ccc3ccccc3c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A16 compound treatment 145640.0 -366.0 -0.01 152240.0 4430.0 0.17 0.1075 0.6443 3178440 Maybridge4_000368 CCNC(=Nc1ccc(Cl)cc1)NCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A17 compound treatment 160400.0 14400.0 0.56 173240.0 25400.0 0.95 1.0698 0.9674 1368926 Maybridge4_000369 CC(=O)OCc1ccccc1Sc2ccccc2C(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A18 compound treatment 149360.0 3350.0 0.13 166800.0 19000.0 0.71 0.596 0.8226 1219932 Maybridge4_000370 C1C=C(Nc2nnnn12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A19 compound treatment 149400.0 3390.0 0.13 168720.0 20900.0 0.78 0.648 0.8144 1528436 Maybridge4_000371 Cn1c(nc2ccccc12)N3C(=O)c4cccc5cccc(C3=O)c45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A20 compound treatment 153200.0 7190.0 0.28 189640.0 41800.0 1.57 1.3075 0.82 1375750 Maybridge4_000372 CC1(CC2CC3(C)C1)CC(C2)(C3)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A21 compound treatment 100640.0 -45400.0 -1.76 96760.0 -51100.0 -1.92 -2.5995 -0.9991 1405005 Maybridge4_000373 O=c1nc2sc3ccccc3n2c(=O)n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A22 compound treatment 158800.0 12800.0 0.5 196400.0 48600.0 1.82 1.6405 0.868 3063251 Maybridge4_000374 C/S(=N\S(=O)(=O)c1ccc(Cl)cc1)/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A23 mock treatment 160160.0 14200.0 0.55 186800.0 39000.0 1.46 1.423 0.9105 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 A24 mock treatment 189240.0 43200.0 1.68 184120.0 36300.0 1.36 2.1498 0.9947 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B01 compound treatment 173360.0 27400.0 1.06 193080.0 45300.0 1.7 1.9519 0.9743 3063252 Maybridge4_000375 C1CN(C1)C(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B02 compound treatment 131600.0 -14400.0 -0.56 150760.0 2950.0 0.11 -0.317 -0.5563 3063253 Maybridge4_000376 CC1CCC(C)N1c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B03 compound treatment 167160.0 21200.0 0.82 175160.0 27300.0 1.03 1.3062 0.9939 3063254 Maybridge4_000377 Cc1ccc(cc1)S(=O)(=O)C[C@H]2O[C@H](C[C@@H]2O)n3cc(I)c(=O)[nH]c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B04 compound treatment 46600.0 -99400.0 -3.86 82520.0 -65300.0 -2.45 -4.4601 -0.976 3063255 Maybridge4_000378 C/C(=N\O)/c1cc(Cl)cc(Cl)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B05 compound treatment 131920.0 -14100.0 -0.55 138800.0 -9010.0 -0.34 -0.6256 -0.9734 3063256 Maybridge4_000379 CCN(CC)Cc1c(C)c(C)c(C)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B06 compound treatment 9560.0 -136000.0 -5.29 11360.0 -136000.0 -5.12 -7.3648 -0.9999 3178441 Maybridge4_000380 Oc1c(Cl)cc(Cl)cc1C2Nc3cc(ccc3-n4cccc24)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B07 compound treatment 129200.0 -16800.0 -0.65 142960.0 -4850.0 -0.18 -0.5898 -0.8712 1227211 Maybridge4_000381 CCC(C)(C)NC(=S)Nc1cccc(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B08 compound treatment 59960.0 -86000.0 -3.34 145520.0 -2290.0 -0.09 -2.4216 -0.7251 3178442 Maybridge4_000382 Cc1c(C)c(C)c2[nH]c(SCc3nc(no3)c4ccc(Cl)cc4)nc2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B09 compound treatment 17240.0 -129000.0 -5.0 49080.0 -98700.0 -3.71 -6.153 -0.9892 3063257 Maybridge4_000383 CSC1=C(C#N)C(=O)NC(S1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B10 compound treatment 129360.0 -16600.0 -0.65 174680.0 26900.0 1.01 0.2564 0.2141 3178443 Maybridge4_000384 C/C(=N\Cc1ccccc1)/c2c(C)cc(C)cc2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B11 compound treatment 96360.0 -49600.0 -1.93 175400.0 27600.0 1.04 -0.6299 -0.288 1417340 Maybridge4_000385 COc1cc(cc(OC)c1OC)C2Nc3ccccc3S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B12 compound treatment 88680.0 -57300.0 -2.22 105880.0 -41900.0 -1.57 -2.6856 -0.9856 1464378 Maybridge4_000386 N#CC1CN(CCc2ccccc2)CN(CCc3ccccc3)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B13 compound treatment 142000.0 -4010.0 -0.16 158400.0 10600.0 0.4 0.1711 0.401 1213608 Maybridge4_000387 COc1cc(CO)c(CC(=O)NN)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B14 compound treatment 139240.0 -6770.0 -0.26 159760.0 11900.0 0.45 0.1315 0.253 1103050 Maybridge4_000388 CC1(C)OC(=O)C(=Cc2ccc[nH]2)C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B15 compound treatment 21560.0 -124000.0 -4.83 70000.0 -77800.0 -2.92 -5.4793 -0.971 1559616 Maybridge4_000389 COc1cc(OC)cc(c1)c2nc(N)c3c(C)c(sc3n2)c4ccc(OC)c(OC)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B16 compound treatment 136000.0 -10000.0 -0.39 157040.0 9230.0 0.35 -0.0296 -0.0569 1513039 Maybridge4_000390 Cc1onc(c1NC(=O)N2CCCC2=O)c3c(Cl)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B17 compound treatment 142760.0 -3250.0 -0.13 174640.0 26800.0 1.01 0.6229 0.6139 1918178 Maybridge4_000391 Cc1ccc(NC(=O)C2C(C3CC2C=C3)C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B18 compound treatment 105360.0 -40600.0 -1.58 133240.0 -14600.0 -0.55 -1.5019 -0.8997 3178444 Maybridge4_000392 CS/C(=N\c1ccccc1C(F)(F)F)/N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B19 compound treatment 47200.0 -98800.0 -3.83 117200.0 -30600.0 -1.15 -3.5232 -0.8803 3178445 Maybridge4_000393 CCOC(=O)c1nc2ccccc2c(=O)n1/N=C/c3cc(Cl)cc(Cl)c3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B20 compound treatment 110840.0 -35200.0 -1.36 161960.0 14100.0 0.53 -0.5893 -0.4025 3063259 Maybridge4_000394 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B21 compound treatment 150000.0 3990.0 0.15 204040.0 56200.0 2.11 1.6018 0.757 3063260 Maybridge4_000395 CSC(=NS(=O)(=O)c1ccccc1)SC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B22 compound treatment 175960.0 30000.0 1.16 189120.0 41300.0 1.55 1.9181 0.9899 1232359 Maybridge4_000396 Cc1onc(c1C(=O)ON2C(=O)CCC2=O)c3c(Cl)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B23 mock treatment 164760.0 18800.0 0.73 165880.0 18100.0 0.68 0.9941 0.9994 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 B24 mock treatment 159840.0 13800.0 0.54 189520.0 41700.0 1.57 1.4864 0.8982 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C01 compound treatment 162360.0 16400.0 0.63 165480.0 17700.0 0.66 0.9176 0.9998 3063261 Maybridge4_000397 CN(C(=O)COc1cc(n(C)n1)C(F)(F)F)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C02 compound treatment 164840.0 18800.0 0.73 182360.0 34500.0 1.3 1.4336 0.9632 1015362 Maybridge4_000398 CCOC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C03 compound treatment 124840.0 -21200.0 -0.82 130680.0 -17100.0 -0.64 -1.0354 -0.9927 1410184 Maybridge4_000399 Cc1ccc(Oc2ncccc2NC(=O)c3ccc(Cl)cc3Cl)c4CCCc41 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C04 compound treatment 159400.0 13400.0 0.52 151240.0 3430.0 0.13 0.4585 0.8563 1430911 Maybridge4_000400 OC(=O)CCC(=O)c1ccc2OCCCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C05 compound treatment 144960.0 -1050.0 -0.04 178240.0 30400.0 1.14 0.7788 0.6815 3063262 Maybridge4_000401 COc1cc(OC)nc(N/C=N/O)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C06 compound treatment 131480.0 -14500.0 -0.56 155800.0 7990.0 0.3 -0.1865 -0.2922 1594886 Maybridge4_000402 Cn1c(=O)cc(Nc2ccccc2)c3c(=O)n(c4ccccc4)c(=O)n(c5ccccc5)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C07 compound treatment 124040.0 -22000.0 -0.85 147760.0 -51.3 0.0 -0.604 -0.7087 3063263 Maybridge4_000403 OC(=O)c1cc(=O)c2c(O)cccc2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C08 compound treatment 185360.0 39400.0 1.53 155800.0 7990.0 0.3 1.2917 0.8301 3063264 Maybridge4_000404 CC(C)NC(=O)Oc1cccc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C09 compound treatment 133680.0 -12300.0 -0.48 159000.0 11200.0 0.42 -0.0412 -0.0648 3178446 Maybridge4_000405 COC(=O)c1ccc(cc1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C10 compound treatment 122680.0 -23300.0 -0.91 149440.0 1630.0 0.06 -0.5968 -0.6578 1676301 Maybridge4_000406 COC(=O)C1C(NC(C(C(=O)OC)S1(=O)=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C11 compound treatment 128040.0 -18000.0 -0.7 171840.0 24000.0 0.9 0.1448 0.127 3063265 Maybridge4_000407 O=C1CC(=NN1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C12 compound treatment 118320.0 -27700.0 -1.07 144160.0 -3650.0 -0.14 -0.8565 -0.7909 1343081 Maybridge4_000408 CC(C1CC1)N(C(=O)c2cc(C)c(Cl)cc2Cl)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C13 compound treatment 17920.0 -128000.0 -4.97 51920.0 -95900.0 -3.6 -6.059 -0.9874 1138226 Maybridge4_000409 COc1ccc2c(c1)nnc3n[nH]c(=O)n32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C14 compound treatment 145160.0 -846.0 -0.03 165440.0 17600.0 0.66 0.4446 0.6712 1419670 Maybridge4_000410 OC(=O)CNC(=O)CSc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C15 compound treatment 119400.0 -26600.0 -1.03 154840.0 7030.0 0.26 -0.5434 -0.51 3063266 Maybridge4_000411 CC1=C(C#N)C(C(=C(C)N1)C#N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C16 compound treatment 31040.0 -115000.0 -4.46 66640.0 -81200.0 -3.05 -5.3084 -0.9827 3178530 Maybridge4_000412 CCC1(CCCCN(C)C1=O)c2cccc(OC(=O)Nc3ccc(OC(F)(F)F)cc3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C17 compound treatment 90760.0 -55200.0 -2.14 150160.0 2350.0 0.09 -1.4534 -0.6775 1346230 Maybridge4_000413 N#Cc1cccc2cccc(Sc3ccccc3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C18 compound treatment 123400.0 -22600.0 -0.88 154760.0 6950.0 0.26 -0.4358 -0.4763 1555561 Maybridge4_000414 COc1ccc(OC)c(CCCc2cc(OC)ccc2OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C19 compound treatment 140720.0 -5290.0 -0.21 162320.0 14500.0 0.54 0.24 0.4125 3063267 Maybridge4_000415 CCN(CC)C(=O)Nc1ccc(OC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C20 compound treatment 44080.0 -102000.0 -3.95 76160.0 -71700.0 -2.69 -4.698 -0.9823 1920088 Maybridge4_000416 S=c1nc(c2ccco2)n(Cc3ccccc3)c(=S)n1/C(=N/Cc4ccccc4)/c5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C21 compound treatment 154360.0 8350.0 0.32 165680.0 17900.0 0.67 0.7034 0.9443 3178531 Maybridge4_000417 FC(F)(F)c1cccc(c1)c2nc3ccccn3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C22 compound treatment 160600.0 14600.0 0.57 141960.0 -5850.0 -0.22 0.2451 0.4036 3178532 Maybridge4_000418 O=C(/C=C\1/NN=C(NC1=O)c2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C23 mock treatment 171200.0 25200.0 0.98 171200.0 23400.0 0.88 1.3119 0.9986 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 C24 mock treatment 152040.0 6030.0 0.23 162680.0 14900.0 0.56 0.5601 0.9256 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D01 compound treatment 109800.0 -36200.0 -1.4 117400.0 -30400.0 -1.14 -1.8004 -0.9947 3178533 Maybridge4_000419 CC1(C)C2(C)CCC1(OC2=O)C(=O)N3NC(=O)[C@H]([C@@H]3c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D02 compound treatment 96640.0 -49400.0 -1.92 85680.0 -62100.0 -2.33 -3.0033 -0.9952 3063268 Maybridge4_000420 FC(F)(F)c1cc(c(Br)c(c1Br)n2cccc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D03 compound treatment 99920.0 -46100.0 -1.79 101280.0 -46500.0 -1.75 -2.4993 -0.9999 1316662 Maybridge4_000421 Clc1ccc(NC(=S)NC(Cn2ccnc2)c3ccccc3)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D04 compound treatment 94920.0 -51100.0 -1.98 128440.0 -19400.0 -0.73 -1.9157 -0.9074 1725083 Maybridge4_000422 Cc1c(N)c2c(cc1N3CCCC3)C(C)(C)CC2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D05 compound treatment 20840.0 -125000.0 -4.86 54040.0 -93800.0 -3.52 -5.9226 -0.9875 1718122 Maybridge4_000423 C1c2sc(Nc3ccccc3)nc2-c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D06 compound treatment 125680.0 -20300.0 -0.79 148240.0 429.0 0.02 -0.5463 -0.6925 3178534 Maybridge4_000424 FC(F)(F)c1cc(cc(c1)S(=O)(=O)N=C2NCCCN2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D07 compound treatment 130560.0 -15400.0 -0.6 159720.0 11900.0 0.45 -0.1077 -0.1441 1138900 Maybridge4_000425 CC(C)(C)NC(=O)NCc1ccncc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D08 compound treatment 151560.0 5550.0 0.22 145120.0 -2690.0 -0.1 0.0809 0.3401 3178535 Maybridge4_000426 FC(F)(F)c1cc(NCN2C(=O)CCC2=O)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D09 compound treatment 140480.0 -5530.0 -0.21 184080.0 36300.0 1.36 0.8109 0.5885 3178536 Maybridge4_000427 COc1cccc(NC2=C(C#N)C(=O)NC(S2)c3cccc(OC)c3O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D10 compound treatment 138240.0 -7770.0 -0.3 161640.0 13800.0 0.52 0.1539 0.2565 3063269 Maybridge4_000428 Clc1ccc(cc1)S(=O)(=O)CS(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D11 compound treatment 66040.0 -80000.0 -3.1 192360.0 44500.0 1.67 -1.0117 -0.287 1023491 Maybridge4_000429 Oc1ccc(Br)cc1C2Nc3ccccc3S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D12 compound treatment 140200.0 -5810.0 -0.23 178760.0 30900.0 1.16 0.662 0.5595 3178537 Maybridge4_000430 C/C(=N\O)/c1nnn(c1C)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D13 compound treatment 153400.0 7390.0 0.29 165240.0 17400.0 0.65 0.6654 0.9316 1381610 Maybridge4_000431 CC1(C)C2CCC(C2)C1(C)NC(=S)NCC3CCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D14 compound treatment 141280.0 -4730.0 -0.18 178360.0 30500.0 1.15 0.6811 0.5866 3178538 Maybridge4_000432 FC(F)(F)c1cccc(CS(=O)(=O)Cc2cccc(c2)C(F)(F)F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D15 compound treatment 138400.0 -7610.0 -0.3 166200.0 18400.0 0.69 0.2793 0.3721 1650135 Maybridge4_000433 Cc1c(C)c(C)c(C(=O)c2ccccc2C(=O)NCc3cccnc3)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D16 compound treatment 132000.0 -14000.0 -0.54 158240.0 10400.0 0.39 -0.1075 -0.1605 1002759 Maybridge4_000434 OC(C(O)C(O)c1nc2ccccc2[nH]1)C(O)c3nc4ccccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D17 compound treatment 115600.0 -30400.0 -1.18 134800.0 -13000.0 -0.49 -1.1795 -0.9238 1658002 Maybridge4_000435 Cc1c(C)c(C)c(CSC2CC(=O)N(C2=O)c3ccccc3)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D18 compound treatment 135640.0 -10400.0 -0.4 161400.0 13600.0 0.51 0.0762 0.1174 3062531 Maybridge4_000436 Clc1ccc(cc1Cl)S(=O)(=O)NC(=N)c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D19 compound treatment 186240.0 40200.0 1.56 155800.0 7990.0 0.3 1.3159 0.8278 2117992 Maybridge4_000437 COc1cccc(/C=N/O)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D20 compound treatment 9320.0 -137000.0 -5.3 13200.0 -135000.0 -5.05 -7.3226 -0.9997 1204180 Maybridge4_000438 Clc1ccc(cc1Cl)S(=O)(=O)NCCc2c[nH]c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D21 compound treatment 158760.0 12800.0 0.49 159000.0 11200.0 0.42 0.6468 0.9967 3062533 Maybridge4_000439 CS/C(=N\S(=O)(=O)c1ccccc1)/N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D22 compound treatment 146160.0 154.0 0.01 133080.0 -14700.0 -0.55 -0.3867 -0.6994 1417838 Maybridge4_000440 COC(=O)CC1(Oc2ccc(Br)cc2C(=O)N1c3ccc(F)cc3F)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D23 mock treatment 154080.0 8070.0 0.31 159840.0 12000.0 0.45 0.5407 0.9841 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 D24 mock treatment 150120.0 4110.0 0.16 152760.0 4950.0 0.19 0.2442 0.9972 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E01 compound treatment 126000.0 -20000.0 -0.78 151200.0 3390.0 0.13 -0.459 -0.5835 3062534 Maybridge4_000441 Cn1nc(OC(C)(C)C(=O)Oc2ccc(Cl)cc2Cl)cc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E02 compound treatment 140560.0 -5450.0 -0.21 145360.0 -2450.0 -0.09 -0.2145 -0.9306 1024184 Maybridge4_000442 CCC(=O)c1ccc(OC)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E03 compound treatment 147560.0 1550.0 0.06 140720.0 -7090.0 -0.27 -0.1456 -0.5334 1519339 Maybridge4_000443 Cc1ccc(Oc2ncccc2NC(=O)CSc3ccccn3)c4CCCc41 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E04 compound treatment 154120.0 8110.0 0.31 238800.0 91000.0 3.41 2.6374 0.769 3062535 Maybridge4_000444 Cc1cc(=O)n(CCO)c(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E05 compound treatment 43360.0 -103000.0 -3.98 57080.0 -90700.0 -3.41 -5.2241 -0.997 3178539 Maybridge4_000445 OC(=O)CC(C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C2=CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E06 compound treatment 122600.0 -23400.0 -0.91 144080.0 -3730.0 -0.14 -0.7412 -0.8066 1643916 Maybridge4_000446 O=C(N1CCCCC1)c2cccc3Cc4ccccc4-c32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E07 compound treatment 126000.0 -20000.0 -0.78 157680.0 9870.0 0.37 -0.287 -0.3337 3178540 Maybridge4_000447 OC(=O)c1oc(C(=O)O)c(OCc2ccccc2)c1OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E08 compound treatment 154120.0 8110.0 0.31 163640.0 15800.0 0.59 0.6427 0.9559 3062536 Maybridge4_000448 O=C(Oc1ccccc1)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E09 compound treatment 143280.0 -2730.0 -0.11 166000.0 18200.0 0.68 0.4079 0.5905 1039079 Maybridge4_000449 OC(=O)c1cccc(Cl)c1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E10 compound treatment 148920.0 2910.0 0.11 149680.0 1870.0 0.07 0.1295 0.9736 1423015 Maybridge4_000450 CC(=O)N[C@@H](Cc1ccccc1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E11 compound treatment 138800.0 -7210.0 -0.28 145240.0 -2570.0 -0.1 -0.2659 -0.8991 3178542 Maybridge4_000451 OC(Cn1ccccc1=N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E12 compound treatment 134760.0 -11200.0 -0.44 190080.0 42300.0 1.59 0.8132 0.4943 3062537 Maybridge4_000452 CC(C1CC1)N(C(=O)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E13 compound treatment 137720.0 -8290.0 -0.32 143480.0 -4330.0 -0.16 -0.3423 -0.9501 1704451 Maybridge4_000453 CN(C)C(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E14 compound treatment 148600.0 2590.0 0.1 165440.0 17600.0 0.66 0.539 0.8054 3178543 Maybridge4_000454 CC(C)(C)C(=O)Nc1ccn([C@H]2C[C@H](O)[C@@H](COC(=O)C(C)(C)C)O2)c(=O)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E15 compound treatment 122240.0 -23800.0 -0.92 179640.0 31800.0 1.19 0.1927 0.1277 3062540 Maybridge4_000455 COc1ccc2c(OC)ccc3C(=O)C=Cc1c32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E16 compound treatment 154320.0 8310.0 0.32 142600.0 -5210.0 -0.2 0.0898 0.238 1289531 Maybridge4_000456 Clc1ccc(cc1)C(=O)OC2CN3CCC2CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E17 compound treatment 153840.0 7830.0 0.3 149640.0 1830.0 0.07 0.2635 0.8455 1672892 Maybridge4_000457 CNC(=O)c1ccccc1S(=O)c2cccc3cccc(C(=O)O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E18 compound treatment 126240.0 -19800.0 -0.77 163640.0 15800.0 0.59 -0.1222 -0.126 3062541 Maybridge4_000458 COc1ccc(OC)c(CCCCc2cc(OC)ccc2OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E19 compound treatment 16440.0 -130000.0 -5.03 32560.0 -115000.0 -4.33 -6.6134 -0.9972 3178544 Maybridge4_000459 Clc1ccc(S/C=C/C(=O)c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E20 compound treatment 19200.0 -127000.0 -4.92 19000.0 -129000.0 -4.83 -6.8976 -1.0 3062542 Maybridge4_000460 C/C(=N\O)/C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E21 compound treatment 145360.0 -646.0 -0.03 153280.0 5470.0 0.21 0.1274 0.6161 3178545 Maybridge4_000461 CC(=O)OC[C@H]1O[C@@H](Nc2ccc(C)cc2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E22 compound treatment 165280.0 19300.0 0.75 162160.0 14300.0 0.54 0.9096 0.987 3062543 Maybridge4_000462 CC1(C)N(O)C(NC1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E23 mock treatment 143480.0 -2530.0 -0.1 138480.0 -9330.0 -0.35 -0.317 -0.8715 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 E24 mock treatment 155800.0 9790.0 0.38 139600.0 -8210.0 -0.31 0.0508 0.1038 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F01 compound treatment 15320.0 -131000.0 -5.07 52800.0 -95000.0 -3.57 -6.107 -0.9852 3178546 Maybridge4_000463 Fc1ccc2CC(=O)C(Cc2c1)C3=Cc4ccc(F)cc4CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F02 compound treatment 147160.0 1150.0 0.04 147200.0 -611.0 -0.02 0.0154 0.3068 1526672 Maybridge4_000464 COc1ccc(CCNC(=O)c2nc3ccccc3c(=O)n2n4cccc4)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F03 compound treatment 143400.0 -2610.0 -0.1 132520.0 -15300.0 -0.57 -0.4773 -0.8191 3062544 Maybridge4_000465 CC(OC(=O)c1cccc(Cl)c1)c2ccc[n+](C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F04 compound treatment 72480.0 -73500.0 -2.85 127080.0 -20700.0 -0.78 -2.5674 -0.8682 1352177 Maybridge4_000466 CSc1cccc(NC(=S)Nc2cc3c(c(N)c2C)C(C)(C)CC3(C)C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F05 compound treatment 156280.0 10300.0 0.4 165680.0 17900.0 0.67 0.7561 0.9691 3062545 Maybridge4_000467 CC(C=C1C(=O)NC(=O)NC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F06 compound treatment 36480.0 -110000.0 -4.25 37280.0 -111000.0 -4.15 -5.9383 -0.9999 3062546 Maybridge4_000468 SC1=NC2(CCCC2)NN1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F07 compound treatment 165200.0 19200.0 0.74 155720.0 7910.0 0.3 0.7365 0.9187 3178547 Maybridge4_000469 C(c1ccc(/N=C/c2ccccn2)cc1)c3ccc(/N=C/c4ccccn4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F08 compound treatment 161920.0 15900.0 0.62 171440.0 23600.0 0.89 1.0637 0.9843 1528873 Maybridge4_000470 O=C1CCC(=O)N1CNc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F09 compound treatment 139160.0 -6850.0 -0.27 152680.0 4870.0 0.18 -0.0586 -0.1818 1318293 Maybridge4_000471 CC(C)(C)C(=O)Nc1ccccc1C(=O)NCc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F10 compound treatment 10680.0 -135000.0 -5.25 16000.0 -132000.0 -4.95 -7.2109 -0.9996 3178548 Maybridge4_000472 Clc1ccc(SCc2ccc(NC(=O)Nc3cccc(Cl)c3)o2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F11 compound treatment 95440.0 -50600.0 -1.96 127960.0 -19900.0 -0.75 -1.9142 -0.9121 3062547 Maybridge4_000473 NC(=N)Nc1nc(cs1)c2ccc(cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F12 compound treatment 12120.0 -134000.0 -5.19 14120.0 -134000.0 -5.02 -7.2213 -0.9998 3178625 Maybridge4_000474 CS/C(=C(/C#N)\C(=O)c1cccs1)/Nc2cccc(Cl)c2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F13 compound treatment 165480.0 19500.0 0.76 173640.0 25800.0 0.97 1.2197 0.9924 3178626 Maybridge4_000475 OC(Cc1ccccc1)(c2ccccc2)c3ccccc3NC(=S)NC4CC5CC4C=C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F14 compound treatment 159880.0 13900.0 0.54 159720.0 11900.0 0.45 0.6967 0.9957 3062548 Maybridge4_000476 Cc1nnsc1C(=O)Nc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F15 compound treatment 49080.0 -96900.0 -3.76 153200.0 5390.0 0.2 -2.5162 -0.6681 1004988 Maybridge4_000477 ON=C(Cc1ccccc1)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F16 compound treatment 113760.0 -32200.0 -1.25 157160.0 9350.0 0.35 -0.6366 -0.4899 3178627 Maybridge4_000478 Cc1onc(c1C(=O)NC(=S)N2CCOCC2)c3c(Cl)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F17 compound treatment 137480.0 -8530.0 -0.33 152560.0 4750.0 0.18 -0.1079 -0.2871 3062549 Maybridge4_000479 NC(=O)Nc1ccc(cc1)/C(=C/c2ccncc2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F18 compound treatment 135440.0 -10600.0 -0.41 140800.0 -7010.0 -0.26 -0.476 -0.977 3062550 Maybridge4_000480 CN(C)C(=S)SCc1c(C)c(C)c(C)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F19 compound treatment 104560.0 -41400.0 -1.61 129800.0 -18000.0 -0.68 -1.6151 -0.9259 3178628 Maybridge4_000481 COc1ccc(cc1)n2c(CC#N)nnc2SCc3c(C)c(C)c(C)c(C)c3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F20 compound treatment 138200.0 -7810.0 -0.3 174760.0 26900.0 1.01 0.501 0.4745 3178629 Maybridge4_000482 CC1(C)ON(C(=N1)NC(=O)NC(=O)c2ccccc2Cl)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F21 compound treatment 167720.0 21700.0 0.84 153360.0 5550.0 0.21 0.743 0.8561 3062551 Maybridge4_000483 O=S(=O)(/N=C/1\NCC2CCCC2N1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F22 compound treatment 124200.0 -21800.0 -0.85 123680.0 -24100.0 -0.91 -1.2387 -0.9994 3178630 Maybridge4_000484 CC(CO)(CO)NC(=S)Nc1ccc(F)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F23 mock treatment 144200.0 -1810.0 -0.07 125280.0 -22500.0 -0.85 -0.6475 -0.7631 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 F24 mock treatment 143920.0 -2090.0 -0.08 159800.0 12000.0 0.45 0.2609 0.5707 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G01 compound treatment 141280.0 -4730.0 -0.18 145200.0 -2610.0 -0.1 -0.199 -0.9569 1441207 Maybridge4_000485 CC(C)(C)c1cc2[nH]c(=N)[nH]c(=N)n2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G02 compound treatment 99360.0 -46600.0 -1.81 100120.0 -47700.0 -1.79 -2.5455 -1.0 1390371 Maybridge4_000486 O=c1c(Cc2ccccc2OCc3ccccc3)coc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G03 compound treatment 137720.0 -8290.0 -0.32 141960.0 -5850.0 -0.22 -0.3826 -0.9827 3062552 Maybridge4_000487 COc1ccccc1C2OC(=O)C[C@H]2C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G04 compound treatment 122480.0 -23500.0 -0.91 135920.0 -11900.0 -0.45 -0.961 -0.9458 1630105 Maybridge4_000488 Brc1ccc(cc1)C(=O)c2cc3OCCCOc3cc2Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G05 compound treatment 148120.0 2110.0 0.08 147280.0 -531.0 -0.02 0.0439 0.5201 1255736 Maybridge4_000489 COc1cc(OC)nc(NCC(NC(=O)c2ccccc2)C(=O)N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G06 compound treatment 139640.0 -6370.0 -0.25 139640.0 -8170.0 -0.31 -0.3915 -0.9942 1191076 Maybridge4_000490 CNc1cc(=O)n(c2ccccc2)c(=O)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G07 compound treatment 146440.0 434.0 0.02 128840.0 -19000.0 -0.71 -0.4916 -0.6902 1024944 Maybridge4_000491 CCOC(=O)c1oc(C(=O)OCC)c(O)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G08 compound treatment 139080.0 -6930.0 -0.27 128640.0 -19200.0 -0.72 -0.6988 -0.9098 3062592 Maybridge4_000492 CC(C)(C)c1ccc2cc(C#N)c(C#N)cc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G09 compound treatment 137680.0 -8330.0 -0.32 141520.0 -6290.0 -0.24 -0.3954 -0.9881 3062593 Maybridge4_000493 O=C1N(CCCCN2C(=O)c3ccccc3S2(=O)=O)S(=O)(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G10 compound treatment 67040.0 -79000.0 -3.06 126120.0 -21700.0 -0.81 -2.7422 -0.865 3062594 Maybridge4_000494 Cc1ccc(NC(=O)N(C2=NCC(C)(C)S2)c3ccc(F)c(Cl)c3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G11 compound treatment 138520.0 -7490.0 -0.29 129520.0 -18300.0 -0.69 -0.6908 -0.9268 1051499 Maybridge4_000495 CC(O)c1ccc2ccccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G12 compound treatment 132920.0 -13100.0 -0.51 140440.0 -7370.0 -0.28 -0.5547 -0.9592 1332464 Maybridge4_000496 OCCOC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G13 compound treatment 149480.0 3470.0 0.13 137120.0 -10700.0 -0.4 -0.1884 -0.4452 1397918 Maybridge4_000497 CCCN(CCC)C(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G14 compound treatment 143600.0 -2410.0 -0.09 134840.0 -13000.0 -0.49 -0.4103 -0.8276 3178631 Maybridge4_000498 CC(C)(C)C(=O)OC[C@H]1O[C@H](C[C@@H]1OC(=O)C(C)(C)C)n2cnc3c(N)ncnc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G15 compound treatment 128560.0 -17400.0 -0.68 149080.0 1270.0 0.05 -0.445 -0.6557 3062595 Maybridge4_000499 O=C(OC1=CC(=O)c2cccc3cccc1c23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G16 compound treatment 139320.0 -6690.0 -0.26 134720.0 -13100.0 -0.49 -0.5309 -0.9555 1645132 Maybridge4_000500 O=C(NC1CCN(Cc2cccc3ccccc23)CC1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G17 compound treatment 137600.0 -8410.0 -0.33 136760.0 -11100.0 -0.41 -0.5239 -0.9929 1430296 Maybridge4_000501 OCc1cccc2cccc(S(=O)c3cccc4cccc(C(=O)O)c34)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G18 compound treatment 113640.0 -32400.0 -1.26 128040.0 -19800.0 -0.74 -1.4127 -0.9685 1284168 Maybridge4_000502 Brc1ccc(Cc2csc3ccccc3c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G19 compound treatment 118280.0 -27700.0 -1.08 148200.0 389.0 0.01 -0.7504 -0.6975 3178632 Maybridge4_000503 FC(F)(F)Oc1ccccc1NC(=O)CC(=O)Nc2ccccc2OC(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G20 compound treatment 137640.0 -8370.0 -0.32 136640.0 -11200.0 -0.42 -0.526 -0.992 1186920 Maybridge4_000504 NNC(=O)C1(CCCC2CCC1)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G21 compound treatment 107880.0 -38100.0 -1.48 111960.0 -35900.0 -1.35 -1.9975 -0.9989 3062596 Maybridge4_000505 FC1(C(=O)Nc2c(Cl)c(Cl)ccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G22 compound treatment 155160.0 9150.0 0.36 141240.0 -6570.0 -0.25 0.0767 0.1775 3178633 Maybridge4_000506 CC(C)(C)OC(=O)Cn1ccc(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G23 mock treatment 132400.0 -13600.0 -0.53 144440.0 -3370.0 -0.13 -0.4628 -0.8524 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 G24 mock treatment 124480.0 -21500.0 -0.84 113120.0 -34700.0 -1.3 -1.5113 -0.977 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H01 compound treatment 150040.0 4030.0 0.16 146440.0 -1370.0 -0.05 0.0743 0.4508 3178634 Maybridge4_000507 O/N=C(/C1CC2CCC1CC2)\c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H02 compound treatment 72440.0 -73600.0 -2.85 94200.0 -53600.0 -2.01 -3.4411 -0.9854 1138209 Maybridge4_000508 N1C(c2cccn2-c3ccccc13)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H03 compound treatment 123080.0 -22900.0 -0.89 140360.0 -7450.0 -0.28 -0.8268 -0.8866 1326325 Maybridge4_000509 Cc1c(C)c(C)c(CN2C(=O)c3ccccc3C2=O)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H04 compound treatment 140200.0 -5810.0 -0.23 154880.0 7070.0 0.27 0.0283 0.0813 3062597 Maybridge4_000510 Cc1c(cc2c(c1n3cccc3)C(C)(C)CC2(C)C)N4CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H05 compound treatment 55720.0 -90300.0 -3.5 79000.0 -68800.0 -2.58 -4.3033 -0.9888 3178635 Maybridge4_000511 Fc1ccc(cc1)C(=O)CSc2nsc(SCC(=O)c3ccc(F)cc3)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H06 compound treatment 9960.0 -136000.0 -5.28 10400.0 -137000.0 -5.16 -7.3793 -0.9999 3178636 Maybridge4_000512 CC(C)C1CCC(C)CC1NC(=S)Nc2cccc(F)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H07 compound treatment 132680.0 -13300.0 -0.52 143520.0 -4290.0 -0.16 -0.4795 -0.8854 1248377 Maybridge4_000513 CC1CCCCN1C(=S)Nc2ccc(cc2)S(=O)(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H08 compound treatment 123080.0 -22900.0 -0.89 134840.0 -13000.0 -0.49 -0.9732 -0.9598 3178637 Maybridge4_000514 COc1cccc(OC)c1C(=O)Nc2cc(c(Cl)cc2OC)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H09 compound treatment 134680.0 -11300.0 -0.44 131960.0 -15900.0 -0.59 -0.7314 -0.9889 1054040 Maybridge4_000515 CC(C)C1=NNC(=O)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H10 compound treatment 135280.0 -10700.0 -0.42 142760.0 -5050.0 -0.19 -0.4283 -0.9366 1253333 Maybridge4_000516 Nc1nc2c(nnn2c3ccccc13)C(=O)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H11 compound treatment 141640.0 -4370.0 -0.17 139600.0 -8210.0 -0.31 -0.3377 -0.9603 1700266 Maybridge4_000517 COc1ccc(CCNC(=S)NCCc2ccccc2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H12 compound treatment 155160.0 9150.0 0.36 140200.0 -7610.0 -0.29 0.0491 0.1078 3178638 Maybridge4_000518 O/N=C(\C#N)/C(=O)c1ccco1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H13 compound treatment 148640.0 2630.0 0.1 149560.0 1750.0 0.07 0.1187 0.9771 1672819 Maybridge4_000519 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H14 compound treatment 140040.0 -5970.0 -0.23 141520.0 -6290.0 -0.24 -0.3307 -1.0 3178639 Maybridge4_000520 Fc1cc(F)c(NC(=S)N2CCOCC2)c(F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H15 compound treatment 132640.0 -13400.0 -0.52 131360.0 -16500.0 -0.62 -0.8033 -0.9962 1546700 Maybridge4_000521 Cc1c(C)c(C)c(C(=O)c2ccccc2C(=O)NN)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H16 compound treatment 136600.0 -9410.0 -0.36 125760.0 -22100.0 -0.83 -0.8433 -0.9323 3062598 Maybridge4_000522 Fc1cccc(NCc2cccs2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H17 compound treatment 135400.0 -10600.0 -0.41 147720.0 -91.3 0.0 -0.2934 -0.713 3178640 Maybridge4_000523 NC(=O)Nc1ccc(cc1)/C(=C/c2ccc(Cl)c(Cl)c2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H18 compound treatment 132800.0 -13200.0 -0.51 133840.0 -14000.0 -0.52 -0.7331 -0.9999 3062599 Maybridge4_000524 CN(C)C(=S)SCC(=O)c1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H19 compound treatment 10040.0 -136000.0 -5.28 8840.0 -139000.0 -5.22 -7.4185 -1.0 1221296 Maybridge4_000525 Cc1cc(C)c2-c3[nH]c(nc3C(C)(C)Cc2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H20 compound treatment 137240.0 -8770.0 -0.34 87600.0 -60200.0 -2.26 -1.8385 -0.8045 1556252 Maybridge4_000526 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H21 compound treatment 135880.0 -10100.0 -0.39 160920.0 13100.0 0.49 0.0701 0.1113 3062600 Maybridge4_000527 CC1CN/C(=N/S(=O)(=O)c2ccccc2)/N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H22 compound treatment 137480.0 -8530.0 -0.33 135160.0 -12700.0 -0.47 -0.5697 -0.9844 1621149 Maybridge4_000528 CC1CC(C)CN(C1)c2ccc(NS(=O)(=O)c3ccccc3)cc2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H23 mock treatment 149800.0 3790.0 0.15 148600.0 789.0 0.03 0.125 0.8326 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 H24 mock treatment 111880.0 -34100.0 -1.32 114120.0 -33700.0 -1.26 -1.8304 -0.9997 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I01 compound treatment 12160.0 -134000.0 -5.19 10240.0 -138000.0 -5.16 -7.3232 -1.0 3062601 Maybridge4_000529 Cc1ccc(Oc2ncc(cc2Cl)C(F)(F)F)c3CCCc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I02 compound treatment 137720.0 -8290.0 -0.32 149040.0 1230.0 0.05 -0.1947 -0.5995 3178641 Maybridge4_000530 CCOC(=O)CSc1nnc(S)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I03 compound treatment 116440.0 -29600.0 -1.15 126440.0 -21400.0 -0.8 -1.3783 -0.9847 3178642 Maybridge4_000531 Cc1nc(cs1)c2cc(C#N)c(SCCNS(=O)(=O)c3ccc(cc3)C(C)(C)C)nc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I04 compound treatment 144920.0 -1090.0 -0.04 147320.0 -491.0 -0.02 -0.0428 -0.9312 1202864 Maybridge4_000532 Cc1ccc(cc1)C(=O)C2C(=O)N(C(=O)N(C2=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I05 compound treatment 123520.0 -22500.0 -0.87 127760.0 -20100.0 -0.75 -1.1491 -0.9973 1219965 Maybridge4_000533 Cc1nn(nc1C(=O)ON2C(=O)C3C4OC(C=C4)C3C2=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I06 compound treatment 62240.0 -83800.0 -3.25 58400.0 -89400.0 -3.36 -4.6711 -0.9999 3062602 Maybridge4_000534 COc1ccc(/C=C\2/C(Oc3ccccc3C2=O)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I07 compound treatment 148800.0 2790.0 0.11 135560.0 -12300.0 -0.46 -0.2485 -0.526 1277364 Maybridge4_000535 CCOC(=O)c1c(O)c(O)c(C(=O)OCC)n1c2ccc(OC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I08 compound treatment 155720.0 9710.0 0.38 138520.0 -9290.0 -0.35 0.0199 0.0388 1178381 Maybridge4_000536 Fc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I09 compound treatment 142480.0 -3530.0 -0.14 159000.0 11200.0 0.42 0.2002 0.4533 1497959 Maybridge4_000537 CC(C)C1CCC(C)CC1NC(=O)c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I10 compound treatment 146880.0 874.0 0.03 148080.0 269.0 0.01 0.0311 0.8794 1039563 Maybridge4_000538 Clc1ccc2oc(cc(=O)c2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I11 compound treatment 141600.0 -4410.0 -0.17 164680.0 16900.0 0.63 0.3268 0.4983 1035419 Maybridge4_000539 O=C(c1ccccc1)c2ccc(cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I12 compound treatment 160120.0 14100.0 0.55 198520.0 50700.0 1.9 1.733 0.8751 3178724 Maybridge4_000540 Sc1nn(c2ccc(Cl)cc2)c(=S)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I13 compound treatment 150360.0 4350.0 0.17 143320.0 -4490.0 -0.17 3.0E-4 0.0011 1060199 Maybridge4_000541 CNC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I14 compound treatment 279960.0 134000.0 5.2 135600.0 -12200.0 -0.46 3.3511 0.6423 3178725 Maybridge4_000542 NNC(=O)c1cc(n[nH]1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I15 compound treatment 217520.0 71500.0 2.77 158760.0 10900.0 0.41 2.2526 0.8031 1005720 Maybridge4_000543 CN(C)c1ccc(Cc2ccc(cc2)N(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I16 compound treatment 101120.0 -44900.0 -1.74 108320.0 -39500.0 -1.48 -2.2796 -0.9968 1587057 Maybridge4_000544 COc1ccccc1C2CCN(Cc3cccc4ccccc34)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I17 compound treatment 141760.0 -4250.0 -0.16 143600.0 -4210.0 -0.16 -0.2283 -0.9998 2075442 Maybridge4_000545 CN1[S+](c2ccccc2C(=O)O)c3cccc4cccc(C1=O)c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I18 compound treatment 62920.0 -83100.0 -3.22 45440.0 -102000.0 -3.84 -4.9964 -0.9962 3178726 Maybridge4_000546 Nc1ccccc1SC(CC(=O)c2ccc(Br)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I19 compound treatment 9880.0 -136000.0 -5.28 9520.0 -138000.0 -5.19 -7.4049 -1.0 1287387 Maybridge4_000547 OCC(O)Cn1c2ccc(Br)cc2c3cc(Br)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I20 compound treatment 139240.0 -6770.0 -0.26 144920.0 -2890.0 -0.11 -0.2624 -0.9236 1441014 Maybridge4_000548 OC(=O)C1(CCCC2(CCC1)C(=O)O)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I21 compound treatment 138760.0 -7250.0 -0.28 103080.0 -44700.0 -1.68 -1.3859 -0.8142 1343250 Maybridge4_000549 O=C1C(C2c3ccccc3Oc4ccccc24)C(=O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I22 compound treatment 124040.0 -22000.0 -0.85 123160.0 -24700.0 -0.93 -1.2569 -0.9992 3062641 Maybridge4_000550 OC[C@H]1O[C@@H](Oc2c[nH]c3ccc(Br)c(Cl)c23)[C@H](O)[C@@H](O)[C@H]1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I23 mock treatment 137720.0 -8290.0 -0.32 156320.0 8510.0 0.32 -0.0015 -0.0034 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 I24 mock treatment 113480.0 -32500.0 -1.26 119960.0 -27900.0 -1.05 -1.6315 -0.9956 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J01 compound treatment 157800.0 11800.0 0.46 142000.0 -5810.0 -0.22 0.1693 0.3341 3062642 Maybridge4_000551 COC(=O)C1CCC(=O)C(C1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J02 compound treatment 12560.0 -133000.0 -5.18 15040.0 -133000.0 -4.98 -7.1848 -0.9998 1601179 Maybridge4_000552 Oc1ccc2ccccc2c1C3Nc4ccccc4-n5cccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J03 compound treatment 133880.0 -12100.0 -0.47 134600.0 -13200.0 -0.5 -0.6833 -0.9997 3062643 Maybridge4_000553 Cc1c(C)c(C)c(CN2CCCCC2)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J04 compound treatment 107160.0 -38800.0 -1.51 146280.0 -1530.0 -0.06 -1.1064 -0.7335 3062644 Maybridge4_000554 CC(=O)Nc1s/c(=N\c2ccc(C)c(C)c2)/n(C(=O)C)c1c3ccc4OCOc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J05 compound treatment 117960.0 -28000.0 -1.09 104680.0 -43100.0 -1.62 -1.9141 -0.9813 1342204 Maybridge4_000555 O=S(=O)(N1CCCCC1)c2ccc(NC(=S)Nc3ccc4OCOc4c3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J06 compound treatment 9560.0 -136000.0 -5.29 10560.0 -137000.0 -5.15 -7.386 -0.9999 3062645 Maybridge4_000556 Clc1ccc(Cl)c(NC(=S)NC(=N)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J07 compound treatment 35960.0 -110000.0 -4.27 30400.0 -117000.0 -4.41 -6.1352 -0.9999 3178727 Maybridge4_000557 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc(CC3C(=O)Nc4ccccc34)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J08 compound treatment 149040.0 3030.0 0.12 160360.0 12500.0 0.47 0.4163 0.8575 3178728 Maybridge4_000558 CN1CCC2(C(C1)N=NN2c3cc(cc(c3)C(F)(F)F)C(F)(F)F)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J09 compound treatment 129160.0 -16800.0 -0.65 122040.0 -25800.0 -0.97 -1.1461 -0.9818 3062646 Maybridge4_000559 Cc1cc(C)c(C(=O)Nc2cccc(c2)C(F)(F)F)c3CC(C)(C)C(=O)c31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J10 compound treatment 162720.0 16700.0 0.65 142120.0 -5690.0 -0.21 0.3075 0.4504 1734956 Maybridge4_000560 Nc1nc2c(nnn2c3ccccc13)c4ccc(Br)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J11 compound treatment 14640.0 -131000.0 -5.1 11960.0 -136000.0 -5.1 -7.2095 -1.0 3178729 Maybridge4_000561 Cc1c(C)c(C)c(C(O)c2ccccc2)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J12 compound treatment 142600.0 -3410.0 -0.13 56760.0 -91100.0 -3.42 -2.5099 -0.7339 3178730 Maybridge4_000562 COc1ccc(cc1)c2c(C#N)nnn2c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J13 compound treatment 153040.0 7030.0 0.27 148160.0 349.0 0.01 0.2022 0.7402 1646858 Maybridge4_000563 CCN1C(C(CCC1=O)C(=O)O)c2ccc(OC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J14 compound treatment 134720.0 -11300.0 -0.44 137880.0 -9930.0 -0.37 -0.5732 -0.9968 1299644 Maybridge4_000564 Fc1cccc(NCCc2ccccn2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J15 compound treatment 151160.0 5150.0 0.2 144360.0 -3450.0 -0.13 0.0498 0.209 3062647 Maybridge4_000565 CCOC(=S)SCc1c(C)c(C)c(C)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J16 compound treatment 148600.0 2590.0 0.1 148680.0 869.0 0.03 0.0942 0.8906 1536926 Maybridge4_000566 O=C(CC#N)NCc1cccs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J17 compound treatment 65480.0 -80500.0 -3.12 17280.0 -131000.0 -4.9 -5.6735 -0.9764 3178731 Maybridge4_000567 Cc1onc(c1NC(=O)Nc2cccc(c2)C(F)(F)F)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J18 compound treatment 91160.0 -54800.0 -2.13 71080.0 -76700.0 -2.88 -3.5411 -0.9889 1727398 Maybridge4_000568 CCc1cccc(C(C)C)c1NS(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J19 compound treatment 140880.0 -5130.0 -0.2 145320.0 -2490.0 -0.09 -0.2068 -0.9407 3062649 Maybridge4_000569 Nn1c(nc2ccccc2c1=O)C(=O)NCc3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J20 compound treatment 135840.0 -10200.0 -0.39 143800.0 -4010.0 -0.15 -0.3854 -0.9128 3178732 Maybridge4_000570 CC1CCCCN1CCCNC(=O)Nc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J21 compound treatment 136520.0 -9490.0 -0.37 129240.0 -18600.0 -0.7 -0.7531 -0.9555 3062650 Maybridge4_000571 Clc1ccc(SCc2ccc(C#N)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J22 compound treatment 135960.0 -10000.0 -0.39 144840.0 -2970.0 -0.11 -0.3545 -0.8743 3178733 Maybridge4_000572 CC1CN(CC(C)O1)c2ccc(NC(=O)c3ccco3)cc2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J23 mock treatment 143760.0 -2250.0 -0.09 133800.0 -14000.0 -0.53 -0.4335 -0.8132 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 J24 mock treatment 135400.0 -10600.0 -0.41 133320.0 -14500.0 -0.54 -0.6756 -0.9905 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K01 compound treatment 102840.0 -43200.0 -1.67 67880.0 -79900.0 -3.0 -3.3056 -0.9621 1258100 Maybridge4_000573 OC(=O)C1CC1C(=O)Nc2ccc(Oc3ccc(Cl)cc3C4CCCCC4)nc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K02 compound treatment 125720.0 -20300.0 -0.79 152000.0 4190.0 0.16 -0.4454 -0.5549 3062651 Maybridge4_000574 CCOC(=O)CCSc1nnc(S)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K03 compound treatment 87000.0 -59000.0 -2.29 109080.0 -38700.0 -1.45 -2.6468 -0.976 1465836 Maybridge4_000575 Fc1ccc(COc2ccc(cc2)C(=O)CSc3ccccn3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K04 compound treatment 125600.0 -20400.0 -0.79 150520.0 2710.0 0.1 -0.488 -0.6113 1182542 Maybridge4_000576 CC1(CC2(C)CC3(C)C1)CC(C2)(C3)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K05 compound treatment 64280.0 -81700.0 -3.17 65280.0 -82500.0 -3.1 -4.4325 -0.9999 3178734 Maybridge4_000577 OC1CCCCCCCCCCC1CCC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K06 compound treatment 133280.0 -12700.0 -0.49 146480.0 -1330.0 -0.05 -0.3845 -0.7747 3062652 Maybridge4_000578 CC(C)CCNC(=O)Oc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K07 compound treatment 139760.0 -6250.0 -0.24 143320.0 -4490.0 -0.17 -0.2906 -0.9843 3178735 Maybridge4_000579 COc1ccc(OC)c2c(=O)cc(oc12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K08 compound treatment 145280.0 -726.0 -0.03 137240.0 -10600.0 -0.4 -0.3005 -0.7554 1674875 Maybridge4_000580 COc1ccccc1C2CCN(CC2)C(=O)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K09 compound treatment 117840.0 -28200.0 -1.09 134080.0 -13700.0 -0.52 -1.1372 -0.9412 3178736 Maybridge4_000581 CC1(C)C2CCC1(C)C(C2)NC(=O)c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K10 compound treatment 151120.0 5110.0 0.2 146480.0 -1330.0 -0.05 0.105 0.513 1672849 Maybridge4_000582 Cc1onc(c1C(=O)N2CC(C2)Oc3ccc(Cl)cc3)c4c(F)cccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K11 compound treatment 155360.0 9350.0 0.36 155320.0 7510.0 0.28 0.4559 0.9922 3062653 Maybridge4_000583 Cc1cc(n[nH]c1=O)c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K12 compound treatment 172440.0 26400.0 1.03 148960.0 1150.0 0.04 0.7557 0.7362 3062654 Maybridge4_000584 Sc1nc(c2ccccc2)n(n1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K13 compound treatment 161200.0 15200.0 0.59 149000.0 1190.0 0.04 0.4484 0.7585 1267527 Maybridge4_000585 CC(C)CCNC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K14 compound treatment 136920.0 -9090.0 -0.35 142400.0 -5410.0 -0.2 -0.3929 -0.9657 3062655 Maybridge4_000586 O=C1C(CCCC1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K15 compound treatment 148280.0 2270.0 0.09 150720.0 2910.0 0.11 0.1396 0.9944 3178737 Maybridge4_000587 Cc1c(cnc2ccccc12)c3nnnn3c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K16 compound treatment 150720.0 4710.0 0.18 153880.0 6070.0 0.23 0.2904 0.9941 1175626 Maybridge4_000588 Cc1ccc(cc1)C(=O)OC2CN3CCC2CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K17 compound treatment 130400.0 -15600.0 -0.61 138560.0 -9250.0 -0.35 -0.6737 -0.9652 3178738 Maybridge4_000589 CN1[S+](c2ccccc2C1=O)c3cccc4cccc(C(=O)O)c34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K18 compound treatment 11280.0 -135000.0 -5.23 9400.0 -138000.0 -5.19 -7.3696 -1.0 3178739 Maybridge4_000590 CC1(C)C2CCC1(C)c3nn(c(c23)C(F)(F)F)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K19 compound treatment 123840.0 -22200.0 -0.86 80440.0 -67400.0 -2.53 -2.3961 -0.8971 1361703 Maybridge4_000591 CCOC(Cn1c2ccccc2c3ccccc13)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K20 compound treatment 133800.0 -12200.0 -0.47 147360.0 -451.0 -0.02 -0.3469 -0.7319 1031191 Maybridge4_000592 OC(=O)C1C(C2CCC1C2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K21 compound treatment 149800.0 3790.0 0.15 123800.0 -24000.0 -0.9 -0.5331 -0.5839 1224135 Maybridge4_000593 Cn1c(nc2ccccc12)C(C#N)C(=O)c3ccccc3I 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K22 compound treatment 119840.0 -26200.0 -1.02 126920.0 -20900.0 -0.78 -1.2723 -0.9918 1062658 Maybridge4_000594 CCOC(=O)C1C(C2c3ccccc3C1c4ccccc24)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K23 mock treatment 118440.0 -27600.0 -1.07 142600.0 -5210.0 -0.2 -0.8946 -0.8228 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 K24 mock treatment 158320.0 12300.0 0.48 125680.0 -22100.0 -0.83 -0.2495 -0.2604 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L01 compound treatment 145600.0 -406.0 -0.02 128720.0 -19100.0 -0.72 -0.5178 -0.7225 3062656 Maybridge4_000595 CCCCN(C(C)C)S(=O)(=O)c1ccc(C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L02 compound treatment 75800.0 -70200.0 -2.72 93040.0 -54800.0 -2.06 -3.3797 -0.9904 3178740 Maybridge4_000596 FC(F)(F)c1cccc(c1)/C(=C/C=C/c2ccccc2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L03 compound treatment 136200.0 -9810.0 -0.38 156080.0 8270.0 0.31 -0.0496 -0.101 3062657 Maybridge4_000597 O=C1NC(=O)C(=CC2CCC=CC2)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L04 compound treatment 131480.0 -14500.0 -0.56 150880.0 3070.0 0.12 -0.3171 -0.5512 1174872 Maybridge4_000598 Fc1cccc(F)c1C(=O)Nc2cccc(NC(=O)c3c(F)cccc3F)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L05 compound treatment 142760.0 -3250.0 -0.13 153120.0 5310.0 0.2 0.0518 0.2199 3178741 Maybridge4_000599 COc1ccc(CC/N=C/c2ccc3OCOc3c2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L06 compound treatment 26040.0 -120000.0 -4.65 24400.0 -123000.0 -4.63 -6.5666 -1.0 3062658 Maybridge4_000600 FC(F)(F)c1cc(C#CCN2CCCCC2)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L07 compound treatment 148920.0 2910.0 0.11 122680.0 -25100.0 -0.94 -0.587 -0.6179 3178820 Maybridge4_000601 CC(C)NC(=S)N1CCCN2C1c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L08 compound treatment 104240.0 -41800.0 -1.62 70400.0 -77400.0 -2.91 -3.2003 -0.962 3062659 Maybridge4_000602 FC(F)(F)c1cccc(c1C(=O)OCC(=O)c2ccc(Cl)cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L09 compound treatment 162120.0 16100.0 0.63 135440.0 -12400.0 -0.46 0.1138 0.1461 1236762 Maybridge4_000603 S=C(Nc1ccccc1)Nc2ccccc2n3cccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L10 compound treatment 138960.0 -7050.0 -0.27 127640.0 -20200.0 -0.76 -0.7286 -0.9052 3062660 Maybridge4_000604 COc1ccc(OC)c(c1)S(=O)(=O)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L11 compound treatment 154400.0 8390.0 0.33 141160.0 -6650.0 -0.25 0.0538 0.131 1138158 Maybridge4_000605 COc1ccc(OCCC(=O)NN)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L12 compound treatment 164200.0 18200.0 0.71 153520.0 5710.0 0.21 0.6507 0.882 3062661 Maybridge4_000606 CN(C)C(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L13 compound treatment 129000.0 -17000.0 -0.66 124720.0 -23100.0 -0.87 -1.0794 -0.9909 3178821 Maybridge4_000607 OC(Cc1ccccc1)(c2ccccc2)c3ccccc3/N=C/c4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L14 compound treatment 14640.0 -131000.0 -5.1 37480.0 -110000.0 -4.14 -6.5322 -0.9947 3178822 Maybridge4_000608 Fc1cccc(N(Cc2cccnc2)C(=S)Nc3ccc(Cl)c(Cl)c3)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L15 compound treatment 140680.0 -5330.0 -0.21 91440.0 -56400.0 -2.12 -1.6422 -0.7725 3062708 Maybridge4_000609 Cc1c(C)c(C)c(CSc2ccccn2)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L16 compound treatment 151560.0 5550.0 0.22 132320.0 -15500.0 -0.58 -0.2587 -0.4173 3062709 Maybridge4_000610 CC(C)NC(=O)NCc1c(F)cccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L17 compound treatment 138320.0 -7690.0 -0.3 122960.0 -24900.0 -0.93 -0.8704 -0.8889 3062710 Maybridge4_000611 Cc1c(C)c(C)c(C(=O)/C=N/N)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L18 compound treatment 142680.0 -3330.0 -0.13 118600.0 -29200.0 -1.1 -0.8665 -0.7849 3062711 Maybridge4_000612 CCc1cccc(C(C)C)c1NC(=O)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L19 compound treatment 134040.0 -12000.0 -0.46 119440.0 -28400.0 -1.06 -1.0812 -0.9308 3062712 Maybridge4_000613 COc1ccc(NC(=S)NCCCC2C=NN=C2O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L20 compound treatment 76720.0 -69300.0 -2.69 59920.0 -87900.0 -3.3 -4.2335 -0.9948 3062713 Maybridge4_000614 CC(C)(C)C1=C(C#N)C(C(=C(NC(=O)NC(=O)c2c(F)cccc2Cl)O1)C#N)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L21 compound treatment 134560.0 -11400.0 -0.44 120640.0 -27200.0 -1.02 -1.0351 -0.9306 1309274 Maybridge4_000615 Cc1cc(C)c(C(=O)Nc2ccc(C)c(C)c2)c(CC(C)(C)C(=O)O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L22 compound treatment 135920.0 -10100.0 -0.39 140480.0 -7330.0 -0.28 -0.4713 -0.9851 3178823 Maybridge4_000616 OCC(CO)(CO)NC(=S)Nc1cc(Cl)cc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L23 mock treatment 152960.0 6950.0 0.27 144520.0 -3290.0 -0.12 0.1034 0.3486 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 L24 mock treatment 144880.0 -1130.0 -0.04 129640.0 -18200.0 -0.68 -0.5131 -0.7509 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M01 compound treatment 144400.0 -1610.0 -0.06 146840.0 -971.0 -0.04 -0.0698 -0.9674 1443995 Maybridge4_000617 CCCc1ccc(Oc2ccc(NC(=O)C3CC3C(=O)O)cn2)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M02 compound treatment 158400.0 12400.0 0.48 134280.0 -13500.0 -0.51 -0.0191 -0.0273 2105374 Maybridge4_000618 Oc1ccc(cc1)C(C#N)N2CCN(CC2)C(C#N)c3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M03 compound treatment 115120.0 -30900.0 -1.2 110200.0 -37600.0 -1.41 -1.8456 -0.9967 1235908 Maybridge4_000619 Cc1nc(cs1)c2cc(C#N)c(SCCC(=O)OC(C)(C)C)nc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M04 compound treatment 111160.0 -34800.0 -1.35 104280.0 -43500.0 -1.63 -2.1113 -0.9956 1332220 Maybridge4_000620 COc1ccc(cc1)C(=O)NC2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M05 compound treatment 145880.0 -126.0 0.0 127080.0 -20700.0 -0.78 -0.5536 -0.7115 3178824 Maybridge4_000621 CN1C2CCC1CC(C2)NC(=O)Cc3ccccc3F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M06 compound treatment 144080.0 -1930.0 -0.07 142440.0 -5370.0 -0.2 -0.1954 -0.9088 3062715 Maybridge4_000622 CCNC(=O)Oc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M07 compound treatment 171920.0 25900.0 1.01 124880.0 -22900.0 -0.86 0.1024 0.0774 3062716 Maybridge4_000623 CN(C)/C=C/C(=O)c1c(O)cc(C)oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M08 compound treatment 99600.0 -46400.0 -1.8 30840.0 -117000.0 -4.39 -4.3775 -0.9225 1250275 Maybridge4_000624 COc1ccccc1C2CCN(CC2)C(=O)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M09 compound treatment 131520.0 -14500.0 -0.56 118600.0 -29200.0 -1.1 -1.1727 -0.9518 1731106 Maybridge4_000625 COc1ccc(Br)cc1COC(=O)C2c3ccccc3Oc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M10 compound treatment 109800.0 -36200.0 -1.4 58760.0 -89100.0 -3.34 -3.3567 -0.9259 1917572 Maybridge4_000626 CCOc1ccc2[nH]c(SCc3c(F)c(F)c(F)c(F)c3F)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M11 compound treatment 166520.0 20500.0 0.8 128680.0 -19100.0 -0.72 0.0551 0.0514 1003070 Maybridge4_000627 Cc1ccc(cc1)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M12 compound treatment 191400.0 45400.0 1.76 159520.0 11700.0 0.44 1.5562 0.8573 3062717 Maybridge4_000628 CSc1nc2c(=S)[nH]c(=S)[nH]c2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M13 compound treatment 171560.0 25600.0 0.99 137560.0 -10300.0 -0.38 0.429 0.4034 3062718 Maybridge4_000629 O/N=C(/C(=N/O)/c1ccccc1)\c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M14 compound treatment 164800.0 18800.0 0.73 140560.0 -7250.0 -0.27 0.3232 0.4152 1781230 Maybridge4_000630 CCOC(=O)CNc1n[nH]c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M15 compound treatment 184920.0 38900.0 1.51 131840.0 -16000.0 -0.6 0.6438 0.3963 3062719 Maybridge4_000631 Cc1cc(C)nc(S/C=C/C(=O)c2ccc(Cl)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M16 compound treatment 147880.0 1870.0 0.07 126480.0 -21300.0 -0.8 -0.5147 -0.6403 1718236 Maybridge4_000632 Cn1c(=O)cc(N2CCOCC2)c3c(=O)n(c4ccccc4)c(=O)n(c5ccccc5)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M17 compound treatment 147320.0 1310.0 0.05 127440.0 -20400.0 -0.76 -0.5046 -0.6585 3178825 Maybridge4_000633 CC(=O)NC1=NN(C(N1C(=O)C)c2cccc3ccccc23)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M18 compound treatment 144520.0 -1490.0 -0.06 119520.0 -28300.0 -1.06 -0.7916 -0.7444 1286292 Maybridge4_000634 O=C(NC(C(=O)c1ccccc1)n2cnccc2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M19 compound treatment 11240.0 -135000.0 -5.23 9120.0 -139000.0 -5.21 -7.3782 -1.0 1171458 Maybridge4_000635 OC(COCc1ccccc1)Cn2c3ccccc3c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M20 compound treatment 135920.0 -10100.0 -0.39 133320.0 -14500.0 -0.54 -0.6613 -0.987 3062720 Maybridge4_000636 C/S(=N\S(=O)(=O)c1ccc(C)cc1)/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M21 compound treatment 128520.0 -17500.0 -0.68 122400.0 -25400.0 -0.95 -1.1541 -0.9861 1311339 Maybridge4_000637 O=C(C(C#N)c1nc2ccccc2[nH]1)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M22 compound treatment 134440.0 -11600.0 -0.45 131680.0 -16100.0 -0.61 -0.7454 -0.9891 1645478 Maybridge4_000638 COC(=O)C1C([C@H]2c3ccccc3[C@@H]1c4ccccc24)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M23 mock treatment 134600.0 -11400.0 -0.44 144720.0 -3090.0 -0.12 -0.395 -0.8633 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 M24 mock treatment 151520.0 5510.0 0.21 144960.0 -2850.0 -0.11 0.0756 0.3161 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N01 compound treatment 153480.0 7470.0 0.29 157560.0 9750.0 0.37 0.4638 0.9934 1273203 Maybridge4_000639 CN(C)CC1(CC(=O)O)CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N02 compound treatment 151080.0 5070.0 0.2 140880.0 -6930.0 -0.26 -0.0447 -0.1372 3178826 Maybridge4_000640 NN/C(=N/S(=O)(=O)c1ccccc1)/N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N03 compound treatment 11160.0 -135000.0 -5.23 9560.0 -138000.0 -5.19 -7.3687 -1.0 3062722 Maybridge4_000641 O=C1NC(=O)C(=C/C=C/c2ccccc2)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N04 compound treatment 158840.0 12800.0 0.5 150600.0 2790.0 0.1 0.4261 0.8374 1678177 Maybridge4_000642 COc1cccc(OC)c1C(=O)Nc2ccccc2NC(=O)c3c(OC)cccc3OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N05 compound treatment 144920.0 -1090.0 -0.04 143800.0 -4010.0 -0.15 -0.1363 -0.8716 1073885 Maybridge4_000643 CCOc1ccc(CCC(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N06 compound treatment 146280.0 274.0 0.01 141000.0 -6810.0 -0.26 -0.1733 -0.6771 3178827 Maybridge4_000644 CS/C(=N\S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N07 compound treatment 143560.0 -2450.0 -0.09 128400.0 -19400.0 -0.73 -0.5823 -0.7925 3062723 Maybridge4_000645 Oc1noc(O)c1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N08 compound treatment 146320.0 314.0 0.01 138080.0 -9730.0 -0.37 -0.2496 -0.6832 3062724 Maybridge4_000646 NC(=S)NC1CC2CC1C=C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N09 compound treatment 160560.0 14600.0 0.56 135920.0 -11900.0 -0.45 0.0837 0.1163 3178828 Maybridge4_000647 CCNc1cc(N)[n+](CC)c2[nH]nc(N)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N10 compound treatment 157040.0 11000.0 0.43 140480.0 -7330.0 -0.28 0.1082 0.2125 1512370 Maybridge4_000648 COc1ccc(cc1CN2CCOCC2)c3cc(c4ccccc4)c(nn3)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N11 compound treatment 158160.0 12200.0 0.47 153360.0 5550.0 0.21 0.4807 0.9325 1288584 Maybridge4_000649 S=C(NC1CC2CC1C=C2)N(CCC#N)Cc3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N12 compound treatment 162880.0 16900.0 0.65 141000.0 -6810.0 -0.26 0.2822 0.4015 3178829 Maybridge4_000650 CC(=O)NCc1c(F)cccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N13 compound treatment 150160.0 4150.0 0.16 149240.0 1430.0 0.05 0.1519 0.8942 1566685 Maybridge4_000651 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2cccc(SC)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N14 compound treatment 155880.0 9870.0 0.38 151560.0 3750.0 0.14 0.3704 0.9075 3062725 Maybridge4_000652 Fc1cccc(Cl)c1CSc2ccccc2C3=NCCCN3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N15 compound treatment 166720.0 20700.0 0.8 139560.0 -8250.0 -0.31 0.3493 0.4056 3178830 Maybridge4_000653 Cc1c(C)c(C)c(CSC2=NCCS2)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N16 compound treatment 140840.0 -5170.0 -0.2 135720.0 -12100.0 -0.45 -0.4626 -0.9325 3062726 Maybridge4_000654 Clc1cc(C[n+]2ccccc2)c3OCOCc3c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N17 compound treatment 145760.0 -246.0 -0.01 136120.0 -11700.0 -0.44 -0.317 -0.7223 3062727 Maybridge4_000655 Cn1c(S)nnc1CC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N18 compound treatment 143920.0 -2090.0 -0.08 110840.0 -37000.0 -1.39 -1.0384 -0.7471 3178831 Maybridge4_000656 CC1CC(C)CN(C1)S(=O)(=O)c2c(C)c(C)c(C)c(C)c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N19 compound treatment 128920.0 -17100.0 -0.66 104200.0 -43600.0 -1.64 -1.6262 -0.9208 3178832 Maybridge4_000657 N#Cc1cccc(CSc2nnc(SCc3cccc(C#N)c3)s2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N20 compound treatment 102520.0 -43500.0 -1.69 54080.0 -93700.0 -3.52 -3.6806 -0.9434 3062728 Maybridge4_000658 CC1(C)ON(C(=N1)NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N21 compound treatment 139520.0 -6490.0 -0.25 136200.0 -11600.0 -0.44 -0.4861 -0.966 3178833 Maybridge4_000659 CC1N=C(SCC#N)N2C(C)N=C(SCC#N)N12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N22 compound treatment 138960.0 -7050.0 -0.27 135080.0 -12700.0 -0.48 -0.5312 -0.9649 1490971 Maybridge4_000660 Nc1ccccc1C(=O)NCc2c(F)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N23 mock treatment 146680.0 674.0 0.03 138080.0 -9730.0 -0.37 -0.2398 -0.6548 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 N24 mock treatment 147120.0 1110.0 0.04 158440.0 10600.0 0.4 0.3126 0.7791 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O01 compound treatment 160240.0 14200.0 0.55 159480.0 11700.0 0.44 0.7002 0.9934 3178834 Maybridge4_000661 COc1ccccc1C2OC(=O)C[C@H]2C(=O)Oc3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O02 compound treatment 124840.0 -21200.0 -0.82 110320.0 -37500.0 -1.41 -1.5757 -0.9671 3178835 Maybridge4_000662 FC(F)(F)c1cc(NC(=S)NCCN2CCNC2=O)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O03 compound treatment 142520.0 -3490.0 -0.14 132760.0 -15100.0 -0.56 -0.4951 -0.8523 1251917 Maybridge4_000663 Cc1ccc(OC(C)(C)C(=O)Nc2ccc(Oc3ccc(F)cc3F)nc2)c4CCCc41 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O04 compound treatment 154200.0 8190.0 0.32 137520.0 -10300.0 -0.39 -0.0483 -0.0966 3178836 Maybridge4_000664 Cc1ccccc1NC2=NCC(C)(C)S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O05 compound treatment 135680.0 -10300.0 -0.4 125520.0 -22300.0 -0.84 -0.8749 -0.9432 1342095 Maybridge4_000665 NC(=O)C1c2ccccc2Oc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O06 compound treatment 175400.0 29400.0 1.14 128400.0 -19400.0 -0.73 0.2913 0.2152 3178916 Maybridge4_000666 CC(C)(C)NC(=O)Oc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O07 compound treatment 145080.0 -926.0 -0.04 79680.0 -68100.0 -2.56 -1.8335 -0.717 1101019 Maybridge4_000667 CC(C)(C)c1cc(c2oc(cc(=O)c2c1)C(=O)O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O08 compound treatment 153240.0 7230.0 0.28 123360.0 -24500.0 -0.92 -0.4504 -0.4694 1485865 Maybridge4_000668 Clc1ccc(OC2CN(C2)C(=O)NCC=C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O09 compound treatment 160000.0 14000.0 0.54 122000.0 -25800.0 -0.97 -0.3011 -0.2711 3178917 Maybridge4_000669 O=C(Oc1ccc2ccccc2c1)C3c4ccccc4Oc5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O10 compound treatment 153920.0 7910.0 0.31 134400.0 -13400.0 -0.5 -0.1388 -0.2354 1074403 Maybridge4_000670 C1CCC(CC1)Nc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O11 compound treatment 170440.0 24400.0 0.95 139080.0 -8730.0 -0.33 0.4386 0.4373 1171317 Maybridge4_000671 COc1cc(OC)cc(c1)C(C)(C)OC(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O12 compound treatment 183320.0 37300.0 1.45 149800.0 1990.0 0.07 1.0765 0.7426 1302360 Maybridge4_000672 OC(=O)Cc1cncc(Br)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O13 compound treatment 156240.0 10200.0 0.4 240840.0 93000.0 3.49 2.7497 0.7825 3063089 Maybridge4_000673 C/C(=N\O)/c1c(O)c2ccccc2n(C)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O14 compound treatment 158640.0 12600.0 0.49 153840.0 6030.0 0.23 0.5066 0.9384 1915396 Maybridge4_000674 CC1(C)OC2C(CO)OC(C2O1)n3cnc4c(=O)[nH]cnc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O15 compound treatment 152560.0 6550.0 0.25 139320.0 -8490.0 -0.32 -0.0455 -0.1117 1665055 Maybridge4_000675 CC(=O)OCc1ccccc1Sc2ccccc2C(=O)NCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O16 compound treatment 152360.0 6350.0 0.25 159360.0 11500.0 0.43 0.4808 0.9642 3063091 Maybridge4_000676 CN1C(=O)/C(=C\NCc2ccccc2)/C(=O)c3c1n(C)c(=O)n(C)c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O17 compound treatment 147440.0 1430.0 0.06 141520.0 -6290.0 -0.24 -0.1276 -0.5261 3178918 Maybridge4_000677 COC(=O)c1cc(=O)nc2O[C@@H]3C(O)[C@@H](CO)OC3n21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O18 compound treatment 160800.0 14800.0 0.57 121960.0 -25900.0 -0.97 -0.2802 -0.2485 1458724 Maybridge4_000678 OC(=O)CCC1(CC2CC3CC(O)(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O19 compound treatment 121560.0 -24400.0 -0.95 69960.0 -77900.0 -2.92 -2.7368 -0.8909 3178919 Maybridge4_000679 CCn1c2ccc(Cl)cc2c3cc(Cl)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O20 compound treatment 138360.0 -7650.0 -0.3 119240.0 -28600.0 -1.07 -0.968 -0.8701 1547077 Maybridge4_000680 Cc1ccc(cc1)S(=O)(=O)N=S(Cc2ccccc2)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O21 compound treatment 166440.0 20400.0 0.79 115720.0 -32100.0 -1.2 -0.291 -0.2018 3063093 Maybridge4_000681 CC(C)(C)c1ccc(=O)[nH]n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O22 compound treatment 78080.0 -67900.0 -2.64 81360.0 -66500.0 -2.49 -3.6272 -0.9996 3178920 Maybridge4_000682 Brc1ccc(NC(=O)N2NC(=O)[C@H]([C@@H]2c3ccccc3)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O23 mock treatment 142280.0 -3730.0 -0.14 150320.0 2510.0 0.09 -0.0357 -0.2066 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 O24 mock treatment 161760.0 15800.0 0.61 154280.0 6470.0 0.24 0.6039 0.9182 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P01 compound treatment 152080.0 6070.0 0.24 164720.0 16900.0 0.63 0.6154 0.909 3063094 Maybridge4_000683 COC(=O)/C=C/c1cn(C2OCC(CO)C2O)c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P02 compound treatment 134800.0 -11200.0 -0.43 156120.0 8310.0 0.31 -0.0869 -0.1625 3178921 Maybridge4_000684 NNC(=O)CS(=O)Cc1cccc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P03 compound treatment 69200.0 -76800.0 -2.98 75120.0 -72700.0 -2.73 -4.0364 -0.999 3063095 Maybridge4_000685 O=C1NC(=O)C(=Cc2cccc3ccccc23)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P04 compound treatment 181320.0 35300.0 1.37 144960.0 -2850.0 -0.11 0.8932 0.6499 3178922 Maybridge4_000686 O/N=C/c1ccc(o1)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P05 compound treatment 8760.0 -137000.0 -5.33 6360.0 -141000.0 -5.31 -7.5194 -1.0 1352669 Maybridge4_000687 COc1cccc(NC(=S)NC(Cc2ccccc2)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P06 compound treatment 130480.0 -15500.0 -0.6 125320.0 -22500.0 -0.84 -1.0229 -0.9863 1145524 Maybridge4_000688 Clc1ccc(Cl)c(NC(=S)Nc2ccc(nc2)N3CCOCC3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P07 compound treatment 167640.0 21600.0 0.84 104680.0 -43100.0 -1.62 -0.5511 -0.3022 1152510 Maybridge4_000689 COc1ccc(CSC2=C(C#N)C(=O)NC3(CCCCC3)S2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P08 compound treatment 161040.0 15000.0 0.58 121160.0 -26700.0 -1.0 -0.2948 -0.2546 3063149 Maybridge4_000690 Clc1ccccc1NC(=O)CC2SC(=NC2=O)NC3CC4CC3C=C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P09 compound treatment 33280.0 -113000.0 -4.37 32960.0 -115000.0 -4.31 -6.1408 -1.0 3178923 Maybridge4_000691 CCNc1cc(N)[n+](CC)c2[nH]nc(/N=C/c3cc(Cl)cc(Cl)c3O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P10 compound treatment 168800.0 22800.0 0.88 145000.0 -2810.0 -0.11 0.5508 0.6184 3063150 Maybridge4_000692 N/C(=N\O)/CN1CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P11 compound treatment 159320.0 13300.0 0.52 131880.0 -15900.0 -0.6 -0.0575 -0.0728 1138088 Maybridge4_000693 S=C(NC1CC2CC1C=C2)N(CCC#N)CC3CCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P12 compound treatment 170800.0 24800.0 0.96 150760.0 2950.0 0.11 0.7585 0.7833 3063152 Maybridge4_000694 Fc1cccc(Cl)c1CSC2=NCCN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P13 compound treatment 170160.0 24200.0 0.94 135320.0 -12500.0 -0.47 0.3312 0.316 1637772 Maybridge4_000695 Cc1onc(c1C(=O)N2CCCN3C2c4ccccc4C3=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P14 compound treatment 172600.0 26600.0 1.03 147320.0 -491.0 -0.02 0.7166 0.6944 3063153 Maybridge4_000696 Nn1c(nc2ccccc2c1=O)C(=O)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P15 compound treatment 148760.0 2750.0 0.11 124520.0 -23300.0 -0.87 -0.5426 -0.6161 1322891 Maybridge4_000697 CCOC(=O)CCc1ccc(OCc2c(C)c(C)c(C)c(C)c2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P16 compound treatment 137120.0 -8890.0 -0.34 137080.0 -10700.0 -0.4 -0.5286 -0.997 3063154 Maybridge4_000698 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NCCCN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P17 compound treatment 144960.0 -1050.0 -0.04 113280.0 -34500.0 -1.3 -0.9451 -0.7289 1180785 Maybridge4_000699 Cc1c(C)c(C)c(C(=O)CCc2cccc(NC(=O)C3CCC3)c2)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P18 compound treatment 151440.0 5430.0 0.21 131520.0 -16300.0 -0.61 -0.2833 -0.438 3063155 Maybridge4_000700 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NC(=N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P19 compound treatment 137680.0 -8330.0 -0.32 111040.0 -36800.0 -1.38 -1.2043 -0.8497 3178924 Maybridge4_000701 N/C(=N\O)/Cc1nc(cs1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P20 compound treatment 111800.0 -34200.0 -1.33 105480.0 -42300.0 -1.59 -2.0619 -0.996 3063157 Maybridge4_000702 Cc1nnsc1C(=O)NC(=O)Nc2cc(Cl)cc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P21 compound treatment 32280.0 -114000.0 -4.41 28000.0 -120000.0 -4.5 -6.2998 -1.0 3178925 Maybridge4_000703 CC1(C)NN(C(=N1)S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P22 compound treatment 128320.0 -17700.0 -0.69 133000.0 -14800.0 -0.56 -0.8783 -0.9945 3063158 Maybridge4_000704 CSc1nc(nc(SC)c1Cl)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P23 mock treatment 138280.0 -7730.0 -0.3 147800.0 -11.3 0.0 -0.2123 -0.7081 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2050 P24 mock treatment 137600.0 -8410.0 -0.33 149280.0 1470.0 0.06 -0.1917 -0.5794 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A01 compound treatment 189920.0 33700.0 1.31 196440.0 43600.0 1.63 2.08 0.9938 3063827 Maybridge4_001761 Cc1noc(C)c1S(=O)(=O)NCC2COc3ccccc3O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A02 compound treatment 147840.0 -8400.0 -0.33 151960.0 -920.0 -0.03 -0.255 -0.7776 3179242 Maybridge4_001762 COc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A03 compound treatment 171240.0 15000.0 0.58 174760.0 21900.0 0.82 0.9921 0.9858 3063828 Maybridge4_001763 COc1ccc(cc1)c2nnsc2N3C(=O)c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A04 compound treatment 155080.0 -1160.0 -0.05 136960.0 -15900.0 -0.6 -0.4544 -0.7584 3179243 Maybridge4_001764 CCn1c(Cn2nnc3ccccc23)nnc1SCC(=O)c4ccc(Br)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A05 compound treatment 114320.0 -41900.0 -1.63 80440.0 -72400.0 -2.72 -3.0727 -0.9698 3179244 Maybridge4_001765 C1Cc2cc(ccc2O1)C3Nc4ccccc4-c5cccn35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A06 compound treatment 177160.0 20900.0 0.81 150360.0 -2520.0 -0.09 0.507 0.6205 3063829 Maybridge4_001766 S=C(Nc1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A07 compound treatment 137760.0 -18500.0 -0.72 123320.0 -29600.0 -1.11 -1.2916 -0.9777 3179245 Maybridge4_001767 O=S(=O)(NCc1ccco1)c2ccc(Oc3c(C#N)cccc3C#N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A08 compound treatment 153840.0 -2400.0 -0.09 135480.0 -17400.0 -0.65 -0.5277 -0.8 3063830 Maybridge4_001768 Nc1nc(Sc2nnc(c3ccncc3)n2c4ccccc4)ncc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A09 compound treatment 203120.0 46900.0 1.82 141600.0 -11300.0 -0.42 0.9867 0.5284 3179246 Maybridge4_001769 Clc1ccc(COC(=O)c2ccc3ccccc3n2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A10 compound treatment 161400.0 5160.0 0.2 156400.0 3520.0 0.13 0.2349 0.9797 3063831 Maybridge4_001770 O=C(CSc1nnc(o1)c2ccncc2)NC(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A11 compound treatment 179720.0 23500.0 0.91 144640.0 -8240.0 -0.31 0.4254 0.4422 1526124 Maybridge4_001771 S=c1[nH]nc(c2ccncc2)n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A12 compound treatment 162240.0 6000.0 0.23 148400.0 -4480.0 -0.17 0.0456 0.1589 3179247 Maybridge4_001772 S=c1[nH]c(=S)c2cnc(nc2[nH]1)N3CCc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A13 compound treatment 171000.0 14800.0 0.57 146600.0 -6280.0 -0.24 0.2382 0.3847 3063832 Maybridge4_001773 Cc1cc(C)c2c(n1)sc3c(=O)n(/N=C/c4ccccc4)cnc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A14 compound treatment 176800.0 20600.0 0.8 157120.0 4240.0 0.16 0.6765 0.8318 3179248 Maybridge4_001774 Fc1ccc(Cn2nc3sc4ccccc4n3c(=O)c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A15 compound treatment 152960.0 -3280.0 -0.13 149960.0 -2920.0 -0.11 -0.1676 -0.9972 3063833 Maybridge4_001775 Clc1ccccc1Cn2nnc3c(=S)[nH]cnc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A16 compound treatment 169680.0 13400.0 0.52 158720.0 5840.0 0.22 0.5236 0.9259 3179249 Maybridge4_001776 CCOC(=O)c1c(C)c(C)sc1NC(=S)Nc2cc(C)nn2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A17 compound treatment 186280.0 30000.0 1.17 132520.0 -20400.0 -0.76 0.2837 0.2036 3063834 Maybridge4_001777 CCOC(=O)c1nnn2c1nc(N(CC)CC)c3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A18 compound treatment 187840.0 31600.0 1.23 158040.0 5160.0 0.19 1.0038 0.8088 3179250 Maybridge4_001778 Cc1cc(C)c2c(n1)sc3c(=O)n(NC(=O)Nc4ccccc4)c(C)nc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A19 compound treatment 178440.0 22200.0 0.86 147960.0 -4920.0 -0.18 0.4784 0.5431 3063835 Maybridge4_001779 CCOC(=O)c1nn(c2ccccc2)c3nc(=O)c(C#N)c(c4ccccc4)n13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A20 compound treatment 182320.0 26100.0 1.01 149840.0 -3040.0 -0.11 0.6347 0.6234 3179251 Maybridge4_001780 O=C(Cn1c(=O)n(c2ccccc2)c(=O)c3cc(sc13)c4ccccc4)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A21 compound treatment 178360.0 22100.0 0.86 153760.0 880.0 0.03 0.6301 0.7338 3179252 Maybridge4_001781 COc1ccc(cc1)n2ncc(NC(=O)NCc3ccccn3)c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A22 compound treatment 203040.0 46800.0 1.82 155640.0 2760.0 0.1 1.3571 0.7462 3063836 Maybridge4_001782 COc1ccc(/C=C/2\N=C(N(/N=C/c3cccnc3)C2=O)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A23 mock treatment 178840.0 22600.0 0.88 150880.0 -2000.0 -0.08 0.5669 0.6442 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 A24 mock treatment 203680.0 47400.0 1.84 155800.0 2920.0 0.11 1.3789 0.7479 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B01 compound treatment 174080.0 17800.0 0.69 208760.0 55900.0 2.1 1.9723 0.8931 3179253 Maybridge4_001783 OC(=O)CSc1nnc([nH]1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B02 compound treatment 168360.0 12100.0 0.47 172880.0 20000.0 0.75 0.8632 0.9746 3063837 Maybridge4_001784 O=c1oc2=C(c3ccccc3)S(=O)(=O)C(=c2o1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B03 compound treatment 179400.0 23200.0 0.9 156760.0 3880.0 0.15 0.7383 0.8111 3179254 Maybridge4_001785 Cc1cc(C)c2c3NC(=O)CN(C(=O)c3sc2n1)c4ccccc4C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B04 compound treatment 114280.0 -42000.0 -1.63 77320.0 -75600.0 -2.84 -3.1566 -0.9653 1701942 Maybridge4_001786 COc1ccc(cc1)N2C(=O)Cc3ccc(OC)cc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B05 compound treatment 168520.0 12300.0 0.48 153560.0 680.0 0.03 0.3549 0.7439 3179255 Maybridge4_001787 Clc1ccc(cc1)n2c(=N)c3cnc(nc3[nH]c2=O)N4CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B06 compound treatment 170640.0 14400.0 0.56 146960.0 -5920.0 -0.22 0.2379 0.3957 1588538 Maybridge4_001788 Cc1oc2cc(O)ccc2c(=O)c1Oc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B07 compound treatment 135880.0 -20400.0 -0.79 110600.0 -42300.0 -1.59 -1.6808 -0.9482 3179256 Maybridge4_001789 COc1ccc(cc1)n/2c(cs\c2=N/Cc3cccnc3)c4cccc(OC)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B08 compound treatment 177400.0 21200.0 0.82 157160.0 4280.0 0.16 0.694 0.8297 3179257 Maybridge4_001790 O=C(c1ccccc1)c2cccc(NC=C3C(=O)NC(=O)NC3=O)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B09 compound treatment 13600.0 -143000.0 -5.53 11080.0 -142000.0 -5.32 -7.6768 -0.9998 1289329 Maybridge4_001791 O=C1C(=C(c2ccccc2)S(=O)(=O)c3ccccc13)Cc4ccc(cc4)c5nnn[nH]5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B10 compound treatment 149600.0 -6640.0 -0.26 143920.0 -8960.0 -0.34 -0.4201 -0.9914 1270319 Maybridge4_001792 O=C(c1ccccn1)c2ccc3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B11 compound treatment 78080.0 -78200.0 -3.03 71600.0 -81300.0 -3.05 -4.3016 -1.0 1356935 Maybridge4_001793 C1C2CC3CC1CC(C2)(C3)c4cn5ccccc5n4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B12 compound treatment 179040.0 22800.0 0.88 155200.0 2320.0 0.09 0.687 0.773 1489551 Maybridge4_001794 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)N2CCC(CC2)NC(=O)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B13 compound treatment 165760.0 9520.0 0.37 147240.0 -5640.0 -0.21 0.1114 0.2618 3063861 Maybridge4_001795 CC(=O)O[C@@H]1[C@H]2CO[C@H](O2)[C@H](OC(=O)C)[C@H]1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B14 compound treatment 159920.0 3680.0 0.14 141240.0 -11600.0 -0.44 -0.2081 -0.4527 1649672 Maybridge4_001796 COc1cc(C(=O)CCC(=O)O)c(OC)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B15 compound treatment 160280.0 4040.0 0.16 159280.0 6400.0 0.24 0.2806 0.9785 1471910 Maybridge4_001797 Cc1ccc(NC(=O)N2C(=O)C3(OCCO3)c4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B16 compound treatment 165400.0 9160.0 0.36 153000.0 120.0 0.0 0.2544 0.716 1205899 Maybridge4_001798 CCOC(=O)C1=C(C)N(C)C(=O)N(C)C1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B17 compound treatment 181000.0 24800.0 0.96 151680.0 -1200.0 -0.05 0.6474 0.6732 3063863 Maybridge4_001799 CC(=O)Nc1ccc2oc(cc(=O)c2c1)c3ccc(C#N)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B18 compound treatment 181120.0 24900.0 0.97 94840.0 -58000.0 -2.18 -0.8578 -0.36 3179258 Maybridge4_001800 Cc1c(sc2nc(C)cc(C)c12)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B19 compound treatment 175200.0 19000.0 0.74 145360.0 -7520.0 -0.28 0.3205 0.4068 3063864 Maybridge4_001801 CC(O)/C=C\c1cc[n+](C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B20 compound treatment 171960.0 15700.0 0.61 135040.0 -17800.0 -0.67 -0.0423 -0.0467 3179259 Maybridge4_001802 O=C(NC(=S)NC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B21 compound treatment 167360.0 11100.0 0.43 158840.0 5960.0 0.22 0.4632 0.9533 1176828 Maybridge4_001803 COC(=O)C1C(C(C(=O)OC)S(=O)(=O)CS1(=O)=O)c2ccc(OC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B22 compound treatment 171480.0 15200.0 0.59 148200.0 -4680.0 -0.18 0.2938 0.4764 1288189 Maybridge4_001804 COC(=O)C1=C(C)NC(=C(C1)C(=O)OC)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B23 mock treatment 162120.0 5880.0 0.23 164960.0 12100.0 0.45 0.4818 0.9494 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 B24 mock treatment 192080.0 35800.0 1.39 149560.0 -3320.0 -0.12 0.8951 0.6412 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C01 compound treatment 132120.0 -24100.0 -0.94 115240.0 -37600.0 -1.41 -1.6608 -0.98 3179260 Maybridge4_001805 O=S(=O)(NCC1COc2ccccc2O1)c3ccc(s3)S(=O)(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C02 compound treatment 21480.0 -135000.0 -5.23 11920.0 -141000.0 -5.29 -7.4383 -1.0 3063865 Maybridge4_001806 Fc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)c5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C03 compound treatment 153240.0 -3000.0 -0.12 145080.0 -7800.0 -0.29 -0.2894 -0.9185 3179353 Maybridge4_001807 COc1ccc(cc1OC)C(=O)NCc2ccc(C#N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C04 compound treatment 125920.0 -30300.0 -1.18 38520.0 -114000.0 -4.29 -3.867 -0.8689 3063866 Maybridge4_001808 O=C(Oc1c(c2ccccc2)c(=O)n3CCc4cccc1c43)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C05 compound treatment 152160.0 -4080.0 -0.16 138000.0 -14900.0 -0.56 -0.5069 -0.8733 3179354 Maybridge4_001809 FC(F)(F)c1ccc(cc1)c2nnc(SCc3ccncc3)n2Cc4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C06 compound treatment 173440.0 17200.0 0.67 125880.0 -27000.0 -1.01 -0.2448 -0.2017 3063867 Maybridge4_001810 CCOC(=O)c1nnn2c1nc(Sc3nc4ccccc4o3)c5ccccc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C07 compound treatment 143160.0 -13100.0 -0.51 129200.0 -23700.0 -0.89 -0.9874 -0.9647 3179355 Maybridge4_001811 COc1cccc(Cc2nnc(o2)c3c(C)onc3c4ccccc4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C08 compound treatment 13920.0 -142000.0 -5.52 10960.0 -142000.0 -5.33 -7.6712 -0.9998 3179356 Maybridge4_001812 C=CCn1c(=S)sc2c(Sc3nnc(o3)c4ccco4)ncnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C09 compound treatment 165120.0 8880.0 0.34 129720.0 -23200.0 -0.87 -0.3711 -0.3969 3063868 Maybridge4_001813 Clc1ccc(Cn2c(=O)n(Cc3ccc(Cl)cc3)c4ccccc4c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C10 compound treatment 168160.0 11900.0 0.46 159240.0 6360.0 0.24 0.4957 0.9527 3179357 Maybridge4_001814 Nc1nc(SCC(=O)NC(=O)Nc2ccccc2)ncc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C11 compound treatment 97680.0 -58600.0 -2.27 77200.0 -75700.0 -2.84 -3.6152 -0.9939 2099392 Maybridge4_001815 Cc1nc2ccc(F)cc2c3N(CCc31)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C12 compound treatment 135040.0 -21200.0 -0.82 131120.0 -21800.0 -0.82 -1.1592 -1.0 3179358 Maybridge4_001816 C=CCSc1ncc2c(=S)[nH]c(=S)[nH]c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C13 compound treatment 157960.0 1720.0 0.07 166720.0 13800.0 0.52 0.4144 0.7913 3179359 Maybridge4_001817 Cc1cc(C)c2c(n1)sc3c(SCC(=O)c4ccc(Br)cc4)ncnc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C14 compound treatment 167840.0 11600.0 0.45 171080.0 18200.0 0.68 0.8012 0.9795 3063869 Maybridge4_001818 C=CCn1nc2sc3ccccc3n2c(=O)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C15 compound treatment 155120.0 -1120.0 -0.04 149360.0 -3520.0 -0.13 -0.1243 -0.8931 3179360 Maybridge4_001819 COc1ccc(Nc2ncnc3n(Cc4ccccc4Cl)nnc23)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C16 compound treatment 175040.0 18800.0 0.73 151320.0 -1560.0 -0.06 0.4743 0.6483 3063871 Maybridge4_001820 CCOC(=O)c1c(C)c(C)sc1NC(=S)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C17 compound treatment 172200.0 16000.0 0.62 143600.0 -9280.0 -0.35 0.1915 0.2696 3179361 Maybridge4_001821 CCOC(=O)c1nnn2c1nc(N3CCN(CC3)c4ccccc4)c5ccccc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C18 compound treatment 14520.0 -142000.0 -5.5 11600.0 -141000.0 -5.3 -7.6377 -0.9998 3063872 Maybridge4_001822 Cc1cc(C)c2c(=O)n(sc2n1)C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C19 compound treatment 119160.0 -37100.0 -1.44 99400.0 -53500.0 -2.01 -2.4367 -0.9867 3179362 Maybridge4_001823 COc1ccc(cc1)C2C(=C(N)N3CCc4cc(OC)c(OC)cc4C3=C2C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C20 compound treatment 190040.0 33800.0 1.31 150400.0 -2480.0 -0.09 0.8614 0.6553 3063873 Maybridge4_001824 CNC(=O)NC(=O)Cn1cnc2sc(cc2c1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C21 compound treatment 148480.0 -7760.0 -0.3 159400.0 6520.0 0.24 -0.04 -0.103 3179363 Maybridge4_001825 COc1cc2CCN3C(N(N=C3C(=O)c4cccs4)c5ccccc5)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C22 compound treatment 181560.0 25300.0 0.98 162120.0 9240.0 0.35 0.9398 0.9022 3063874 Maybridge4_001826 Fc1ccc(/C=N/N2C(=O)/C(=C/c3ccco3)/N=C2c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C23 mock treatment 157280.0 1040.0 0.04 161640.0 8760.0 0.33 0.2609 0.7877 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 C24 mock treatment 168160.0 11900.0 0.46 163040.0 10200.0 0.38 0.5966 0.9954 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D01 compound treatment 171760.0 15500.0 0.6 138640.0 -14200.0 -0.53 0.0478 0.0594 3179364 Maybridge4_001827 CCOC(=O)CSc1nc(Nc2ccc(OC)cc2)c3cnc(nc3n1)N(CC)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D02 compound treatment 188000.0 31800.0 1.23 165480.0 12600.0 0.47 1.2056 0.9135 1016783 Maybridge4_001828 CSc1ncnc2[nH]cnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D03 compound treatment 151600.0 -4640.0 -0.18 141120.0 -11800.0 -0.44 -0.4395 -0.9219 3179365 Maybridge4_001829 CCOC(=O)CSc1nc(Nc2ccccc2)c3cnc(nc3n1)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D04 compound treatment 159480.0 3240.0 0.13 152280.0 -600.0 -0.02 0.0729 0.5712 3063875 Maybridge4_001830 CCn1c(C)[n+](CC)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D05 compound treatment 203560.0 47300.0 1.84 137280.0 -15600.0 -0.59 0.8842 0.4588 3179366 Maybridge4_001831 Nc1c(C#N)c(cc2c3ccccc3oc(=O)c12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D06 compound treatment 142640.0 -13600.0 -0.53 122800.0 -30100.0 -1.13 -1.1715 -0.94 1156367 Maybridge4_001832 CC(=O)Oc1ccc2c(=O)c(Oc3ccc(Cl)cc3)c(C)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D07 compound treatment 151440.0 -4800.0 -0.19 150080.0 -2800.0 -0.11 -0.2061 -0.9632 3179367 Maybridge4_001833 CC(/C=N/N1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D08 compound treatment 147840.0 -8400.0 -0.33 149640.0 -3240.0 -0.12 -0.3166 -0.9096 3063876 Maybridge4_001834 COC(=O)c1sc(=S)sc1C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D09 compound treatment 132000.0 -24200.0 -0.94 121000.0 -31900.0 -1.2 -1.5112 -0.9929 1027030 Maybridge4_001835 Clc1ccc2OC(CC(=O)c2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D10 compound treatment 145760.0 -10500.0 -0.41 163520.0 10600.0 0.4 -0.0053 -0.0092 1567173 Maybridge4_001836 C=CCN1C(=O)NC2(CCCCC2)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D11 compound treatment 175760.0 19500.0 0.76 172800.0 19900.0 0.75 1.0641 1.0 1014811 Maybridge4_001837 O=C(N(C(=O)c1ccccc1)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D12 compound treatment 157080.0 836.0 0.03 154920.0 2040.0 0.08 0.0771 0.9269 1422860 Maybridge4_001838 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D13 compound treatment 146680.0 -9560.0 -0.37 157440.0 4560.0 0.17 -0.1414 -0.346 3063327 Maybridge4_001839 CCOc1ccc2nc(S/C=C/C(=O)c3ccc(Cl)cc3)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D14 compound treatment 161840.0 5600.0 0.22 159560.0 6680.0 0.25 0.3308 0.9974 1403045 Maybridge4_001840 COc1cc(c(OC)cc1C)c2cc(OC)c(C)cc2OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D15 compound treatment 176600.0 20400.0 0.79 156160.0 3280.0 0.12 0.6455 0.8076 1267535 Maybridge4_001841 OC(=O)C(Sc1ccccc1C(=O)O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D16 compound treatment 164760.0 8520.0 0.33 172160.0 19300.0 0.72 0.7453 0.9369 3063328 Maybridge4_001842 CC(C)(C)[C@H]1COC(=N1)CC2=N[C@H](CO2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D17 compound treatment 170160.0 13900.0 0.54 151840.0 -1040.0 -0.04 0.3542 0.6543 1035033 Maybridge4_001843 O=C(C1=NNCC1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D18 compound treatment 166360.0 10100.0 0.39 168280.0 15400.0 0.58 0.6862 0.9822 1414609 Maybridge4_001844 CC(=O)Oc1ccc2c(=O)c(c3nc4ccccc4n3C)c(C)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D19 compound treatment 161680.0 5440.0 0.21 147600.0 -5280.0 -0.2 0.009 0.0312 3063329 Maybridge4_001845 CC1=CC(=O)OC(C1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D20 compound treatment 159320.0 3080.0 0.12 170320.0 17400.0 0.65 0.5472 0.8225 1054135 Maybridge4_001846 CCc1c(O)nc2ccccn2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D21 compound treatment 153800.0 -2440.0 -0.09 136880.0 -16000.0 -0.6 -0.4917 -0.8087 1416442 Maybridge4_001847 CCN(CC)CCC1S(=O)(=O)CC(CS1(=O)=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D22 compound treatment 100760.0 -55500.0 -2.15 109000.0 -43900.0 -1.65 -2.6868 -0.9913 3179368 Maybridge4_001848 C(/N=C/c1cn(nc1c2ccccc2)c3ccccc3)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D23 mock treatment 160720.0 4480.0 0.17 148360.0 -4520.0 -0.17 0.0029 0.0117 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 D24 mock treatment 159120.0 2880.0 0.11 156840.0 3960.0 0.15 0.184 0.99 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E01 compound treatment 169520.0 13300.0 0.52 166280.0 13400.0 0.5 0.7199 0.9999 3063330 Maybridge4_001849 O=C(Nc1cccs1)N2CCN(CC2)C(=O)C3CCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E02 compound treatment 145520.0 -10700.0 -0.42 116200.0 -36700.0 -1.38 -1.2677 -0.8814 3179369 Maybridge4_001850 Clc1ccc(NC(=O)N2N=C3C(CCc4ccccc34)C2c5cccs5)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E03 compound treatment 142880.0 -13400.0 -0.52 129840.0 -23000.0 -0.86 -0.9781 -0.9701 3063331 Maybridge4_001851 CC(C)(C)c1cc(C(=O)NCc2ccc(C#N)cc2)n(Cc3ccccc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E04 compound treatment 143880.0 -12400.0 -0.48 132480.0 -20400.0 -0.77 -0.8806 -0.9746 3179370 Maybridge4_001852 C1Cc2ccccc2N1c3nnc(c4ccccc4)c(n3)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E05 compound treatment 169480.0 13200.0 0.51 120680.0 -32200.0 -1.21 -0.4914 -0.3742 3179371 Maybridge4_001853 Cn1nc(cc1C(F)(F)F)c2ccc(s2)S(=O)(=O)N3CCCN(CC3)C(=O)OC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E06 compound treatment 144080.0 -12200.0 -0.47 117080.0 -35800.0 -1.34 -1.2838 -0.9015 3063332 Maybridge4_001854 CCOC(=O)c1nnn2c1nc(Sc3nnc(c4ccncc4)n3C)c5ccccc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E07 compound treatment 140920.0 -15300.0 -0.59 145720.0 -7160.0 -0.27 -0.6104 -0.9356 3179372 Maybridge4_001855 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCCN(CC2)C(=O)OC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E08 compound treatment 186080.0 29800.0 1.16 162800.0 9920.0 0.37 1.0818 0.8896 1566406 Maybridge4_001856 CNc1nc(=S)[nH]c2sc3CCCCc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E09 compound treatment 177360.0 21100.0 0.82 144520.0 -8360.0 -0.31 0.3575 0.4075 3179373 Maybridge4_001857 OC[C@@H]1O[C@@H](C[C@H]1O)n2cnc3c(=O)[nH]cnc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E10 compound treatment 180200.0 24000.0 0.93 151880.0 -1000.0 -0.04 0.6307 0.678 3063334 Maybridge4_001858 COc1ccc(Nc2ncc(C#N)c(N)n2)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E11 compound treatment 177640.0 21400.0 0.83 162920.0 10000.0 0.38 0.8535 0.9361 3179374 Maybridge4_001859 CCNc1nc(=S)[nH]c2n(ncc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E12 compound treatment 161320.0 5080.0 0.2 156360.0 3480.0 0.13 0.2316 0.9801 3063335 Maybridge4_001860 CCN(CC)c1ncc2c(=S)[nH]c(=S)[nH]c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E13 compound treatment 139080.0 -17200.0 -0.67 148280.0 -4600.0 -0.17 -0.593 -0.8619 3179375 Maybridge4_001861 Cc1cc(C)c2c(n1)sc3c(Sc4nnc(o4)c5ccncc5)ncnc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E14 compound treatment 131360.0 -24900.0 -0.97 124440.0 -28400.0 -1.07 -1.4375 -0.9987 3179376 Maybridge4_001862 CCOC(=O)N1CCc2c(C1)sc3ncn(Cc4ccc(Cl)cc4)c(=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E15 compound treatment 125360.0 -30900.0 -1.2 134000.0 -18900.0 -0.71 -1.3484 -0.9686 3063336 Maybridge4_001863 Clc1ccccc1C2C3CCc4ccccc4C3=NN2C(=S)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E16 compound treatment 153120.0 -3120.0 -0.12 156880.0 4000.0 0.15 0.0204 0.106 1616264 Maybridge4_001864 CC1=NN(C(=O)C1)c2ncnc3sc4CCCCc4c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E17 compound treatment 138880.0 -17400.0 -0.67 136920.0 -16000.0 -0.6 -0.9 -0.9983 3179377 Maybridge4_001865 CCOC(=O)c1nnn2c1nc(N(Cc3ccccc3)Cc4ccccc4)c5ccccc52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E18 compound treatment 157880.0 1640.0 0.06 153800.0 920.0 0.03 0.0693 0.959 3063337 Maybridge4_001866 NNC(=O)/C(=C\c1ccccc1)/NC(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E19 compound treatment 151080.0 -5160.0 -0.2 130120.0 -22800.0 -0.85 -0.7457 -0.8499 3179378 Maybridge4_001867 Cc1ccc(Cc2nn3c(nn(c4ccc(Cl)cc4)c3nc2=O)C(=O)c5cccs5)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E20 compound treatment 139920.0 -16300.0 -0.63 151480.0 -1400.0 -0.05 -0.485 -0.7631 3063338 Maybridge4_001868 Fc1ccc(Cn2nc3CSc4ccccc4-n3c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E21 compound treatment 147560.0 -8680.0 -0.34 143960.0 -8920.0 -0.33 -0.475 -1.0 3063339 Maybridge4_001869 Cc1ccc2nc(C)c3CCN(c3c2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E22 compound treatment 180160.0 23900.0 0.93 134920.0 -18000.0 -0.67 0.1795 0.1565 3179379 Maybridge4_001870 Fc1ccc(/C=C\2/N=C(N(CC(=O)c3ccco3)C2=O)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E23 mock treatment 153640.0 -2600.0 -0.1 171960.0 19100.0 0.72 0.4349 0.6014 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 E24 mock treatment 162520.0 6280.0 0.24 156280.0 3400.0 0.13 0.2624 0.9545 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F01 compound treatment 172920.0 16700.0 0.65 185160.0 32300.0 1.21 1.3142 0.9568 3179475 Maybridge4_001871 Cc1cc(nc2oc3C(=O)N(CC(=O)Nc3c12)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F02 compound treatment 204760.0 48500.0 1.88 177640.0 24800.0 0.93 1.9882 0.9471 1429948 Maybridge4_001872 CC1(C)C(NC(=O)C2CCCCC2)[C@]3(C)CCC1C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F03 compound treatment 159000.0 2760.0 0.11 125640.0 -27200.0 -1.02 -0.6473 -0.6297 3179476 Maybridge4_001873 CCN(CC)c1ncc2c(NCc3ccccc3)nc(SCc4ccccc4)nc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F04 compound treatment 164600.0 8360.0 0.32 180960.0 28100.0 1.05 0.9745 0.8838 1050962 Maybridge4_001874 NC(=O)CCCCC1CCSS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F05 compound treatment 176720.0 20500.0 0.79 176600.0 23700.0 0.89 1.1913 0.9984 3179477 Maybridge4_001875 O=C(CN1CCc2ccccc12)Nc3scc4c3c(=O)oc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F06 compound treatment 214120.0 57900.0 2.25 215400.0 62500.0 2.35 3.2471 0.9998 3063341 Maybridge4_001876 CC1(C)C2CCC1(C)c3noc(c23)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F07 compound treatment 151320.0 -4920.0 -0.19 142560.0 -10300.0 -0.39 -0.409 -0.947 1040822 Maybridge4_001877 Cc1ccc(NC(=O)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F08 compound treatment 139520.0 -16700.0 -0.65 147480.0 -5400.0 -0.2 -0.6021 -0.8858 1502018 Maybridge4_001878 COc1ccc2oc(cc(=O)c2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F09 compound treatment 17240.0 -139000.0 -5.39 14520.0 -138000.0 -5.19 -7.4856 -0.9998 3063363 Maybridge4_001879 O=C1/C(=C/c2ccc(cc2)c3nnn[nH]3)/C(Oc4ccccc14)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F10 compound treatment 158880.0 2640.0 0.1 161680.0 8800.0 0.33 0.3059 0.8846 3063364 Maybridge4_001880 CC1(C)NC(=O)N(CC=C)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F11 compound treatment 111960.0 -44300.0 -1.72 93120.0 -59800.0 -2.24 -2.8009 -0.9913 3063365 Maybridge4_001881 Clc1ccccc1CNC(=S)NC2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F12 compound treatment 130360.0 -25900.0 -1.0 127280.0 -25600.0 -0.96 -1.3895 -0.9998 3063366 Maybridge4_001882 Fc1ccc(cc1)N(Cc2ccc(Br)cc2)C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F13 compound treatment 52800.0 -103000.0 -4.01 65120.0 -87800.0 -3.29 -5.1671 -0.9952 1687915 Maybridge4_001883 CC1(C)CC(=O)C=C(C1)Sc2nc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F14 compound treatment 148320.0 -7920.0 -0.31 176640.0 23800.0 0.89 0.4132 0.438 3063367 Maybridge4_001884 C[n+]1ccc(CCc2cc[n+](C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F15 compound treatment 166120.0 9880.0 0.38 132200.0 -20700.0 -0.78 -0.2779 -0.321 1612566 Maybridge4_001885 CCC(=O)N1N(C(=O)CC)c2cc(Cl)ccc2-n3c1nn(C(=O)CC)c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F16 compound treatment 121440.0 -34800.0 -1.35 122520.0 -30400.0 -1.14 -1.7606 -0.9964 1406161 Maybridge4_001886 CC(=O)Oc1c(I)c(=O)n(C)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F17 compound treatment 163840.0 7600.0 0.29 158920.0 6040.0 0.23 0.3687 0.9916 3179478 Maybridge4_001887 CCSC(=O)NC1CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F18 compound treatment 160520.0 4280.0 0.17 153880.0 1000.0 0.04 0.1439 0.8457 3179479 Maybridge4_001888 C1C(=CC(=NN=C1c2ccccc2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F19 compound treatment 164240.0 8000.0 0.31 163400.0 10500.0 0.39 0.4986 0.9929 1002179 Maybridge4_001889 Clc1ccc(cc1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F20 compound treatment 174040.0 17800.0 0.69 140160.0 -12700.0 -0.48 0.1507 0.1795 3063368 Maybridge4_001890 CCC(C)Sc1nnc(S)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F21 compound treatment 161000.0 4760.0 0.18 173720.0 20800.0 0.78 0.6836 0.8506 3179480 Maybridge4_001891 COC(=O)/C(=C/c1ccccc1)/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F22 compound treatment 216320.0 60100.0 2.33 147560.0 -5320.0 -0.2 1.5071 0.6442 1172572 Maybridge4_001892 O=c1[nH]cc(NCc2ccccc2)c(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F23 mock treatment 165560.0 9320.0 0.36 150880.0 -2000.0 -0.08 0.2025 0.5486 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 F24 mock treatment 165000.0 8760.0 0.34 147400.0 -5480.0 -0.21 0.0948 0.2387 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G01 compound treatment 152920.0 -3320.0 -0.13 162880.0 10000.0 0.38 0.1742 0.4389 3179481 Maybridge4_001893 CCOC(=O)N1CCC(CC1)NC(=O)CCCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G02 compound treatment 143120.0 -13100.0 -0.51 142520.0 -10400.0 -0.39 -0.635 -0.9911 3179482 Maybridge4_001894 O=C1CSC2=NC3=C(CCc4ccccc34)C(N12)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G03 compound treatment 138920.0 -17300.0 -0.67 149000.0 -3880.0 -0.15 -0.5783 -0.8408 3063369 Maybridge4_001895 CCOC(=O)c1ncn(Cc2ccccc2)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G04 compound treatment 165920.0 9680.0 0.38 150560.0 -2320.0 -0.09 0.2039 0.5291 3063370 Maybridge4_001896 S=c1[nH]nc(Cn2nnc3ccccc23)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G05 compound treatment 140680.0 -15600.0 -0.6 141080.0 -11800.0 -0.44 -0.7402 -0.9884 3179483 Maybridge4_001897 COc1cccc(Cc2nnc(o2)c3ccc(s3)c4cccs4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G06 compound treatment 163600.0 7360.0 0.29 164920.0 12000.0 0.45 0.5214 0.9754 3063371 Maybridge4_001898 Cn1nc2c3ccccc3n(Cc4ccccc4)c2nc1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G07 compound treatment 142040.0 -14200.0 -0.55 145400.0 -7480.0 -0.28 -0.5882 -0.951 3179484 Maybridge4_001899 CCOC(=O)c1cnn(C(=O)Cc2cccc(OC)c2)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G08 compound treatment 166560.0 10300.0 0.4 143560.0 -9320.0 -0.35 0.0357 0.0671 1696254 Maybridge4_001900 COc1cc(OC)c2nc(C)c3CCSc3c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G09 compound treatment 145840.0 -10400.0 -0.4 147080.0 -5800.0 -0.22 -0.4394 -0.958 3179485 Maybridge4_001901 CC(=O)Nc1ccccc1OCC2CC(=NO2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G10 compound treatment 153440.0 -2800.0 -0.11 150040.0 -2840.0 -0.11 -0.1523 -0.9999 3179486 Maybridge4_001902 C1Sc2nnc(c3ccccc3)n2N=C1c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G11 compound treatment 100120.0 -56100.0 -2.18 101080.0 -51800.0 -1.94 -2.9145 -0.9984 3063373 Maybridge4_001903 S=c1nc(Nc2ccccc2)c3cnn(c4ccccc4)c3[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G12 compound treatment 147760.0 -8480.0 -0.33 162000.0 9120.0 0.34 0.0093 0.0195 3179487 Maybridge4_001904 CN1CCN(CC1)c2ncc3c(=S)[nH]c(=S)[nH]c3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G13 compound treatment 38520.0 -118000.0 -4.57 39840.0 -113000.0 -4.24 -6.2298 -0.9993 3063374 Maybridge4_001905 CCn1c(Sc2ncnc3c2sc4nc(C)cc(C)c43)nnc1c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G14 compound treatment 148360.0 -7880.0 -0.31 140960.0 -11900.0 -0.45 -0.5326 -0.9828 3179488 Maybridge4_001906 CCOC(=O)N1CCc2c(C(=O)OCC)c(NC(=S)N3CCc4ccccc34)sc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G15 compound treatment 83800.0 -72400.0 -2.81 93240.0 -59600.0 -2.24 -3.5703 -0.9936 3179489 Maybridge4_001907 CCNC(=S)N1N=C2C(CCc3ccccc23)C1c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G16 compound treatment 75640.0 -80600.0 -3.13 78960.0 -73900.0 -2.77 -4.1732 -0.9982 1303898 Maybridge4_001908 CC1=NN(C(=O)C1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G17 compound treatment 156440.0 196.0 0.01 165720.0 12800.0 0.48 0.3461 0.7182 3063375 Maybridge4_001909 CCOC(=O)C1=NN(C2N1CCc3cc(OC)c(OC)cc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G18 compound treatment 138480.0 -17800.0 -0.69 137800.0 -15100.0 -0.57 -0.8876 -0.9952 3179490 Maybridge4_001910 COc1cc(/C=C\2/N=C(N(C)C2=O)c3ccccc3)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G19 compound treatment 132040.0 -24200.0 -0.94 133640.0 -19200.0 -0.72 -1.1747 -0.9916 3063377 Maybridge4_001911 Cc1c(C)c(=O)n(Cc2ccc(Br)cc2)c(=O)n1Cc3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G20 compound treatment 158480.0 2240.0 0.09 154320.0 1440.0 0.05 0.0996 0.9741 3179491 Maybridge4_001912 O=C(Cn1nc2CSc3ccccc3-n2c1=O)NC(=O)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G21 compound treatment 141440.0 -14800.0 -0.57 137600.0 -15300.0 -0.57 -0.8117 -1.0 3179492 Maybridge4_001913 CCOC(=O)c1sc2nc(C)cc(C)c2c1NC(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G22 compound treatment 161760.0 5520.0 0.21 149720.0 -3160.0 -0.12 0.0675 0.2758 1150256 Maybridge4_001914 N(c1ccccc1)c2ncnc3sc(cc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G23 mock treatment 138920.0 -17300.0 -0.67 147440.0 -5440.0 -0.2 -0.6197 -0.8821 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 G24 mock treatment 142840.0 -13400.0 -0.52 146520.0 -6360.0 -0.24 -0.5365 -0.9376 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H01 compound treatment 145600.0 -10600.0 -0.41 162880.0 10000.0 0.38 -0.0266 -0.0477 3179493 Maybridge4_001915 COc1cc(cc(OC)c1OC)c2nnc(SCC(=O)c3ccco3)n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H02 compound treatment 11640.0 -145000.0 -5.61 11480.0 -141000.0 -5.31 -7.7199 -0.9996 1202312 Maybridge4_001916 Clc1ccc(OC2CN(C2)C(=O)N3CC(C3)Oc4ccc(Cl)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H03 compound treatment 139840.0 -16400.0 -0.64 161200.0 8320.0 0.31 -0.2293 -0.3234 3179494 Maybridge4_001917 O=C(CN1CCc2ccccc12)Nc3nnc(s3)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H04 compound treatment 144280.0 -12000.0 -0.46 149760.0 -3120.0 -0.12 -0.411 -0.8586 1178262 Maybridge4_001918 COc1ccc(cc1)c2nc3cc4Nc5ccccc5Oc4cc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H05 compound treatment 176600.0 20400.0 0.79 219240.0 66400.0 2.49 2.3196 0.8878 3063402 Maybridge4_001919 O=C(Nc1scc2c1c(=O)oc3ccccc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H06 compound treatment 166120.0 9880.0 0.38 152600.0 -280.0 -0.01 0.2635 0.6875 3179495 Maybridge4_001920 FC(F)(F)C(NC(=O)c1cccnc1)(N2CCCC2=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H07 compound treatment 142800.0 -13400.0 -0.52 141400.0 -11500.0 -0.43 -0.6735 -0.9955 1117011 Maybridge4_001921 COc1cccc(NC(=O)N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H08 compound treatment 124360.0 -31900.0 -1.24 154440.0 1560.0 0.06 -0.8334 -0.6729 3063403 Maybridge4_001922 NC(=O)c1cc(Cl)c(Cl)cc1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H09 compound treatment 145280.0 -11000.0 -0.43 136040.0 -16800.0 -0.63 -0.7477 -0.9814 3179496 Maybridge4_001923 O[C@H]1[C@@H](Oc2ccccc2C1=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H10 compound treatment 142360.0 -13900.0 -0.54 139160.0 -13700.0 -0.51 -0.745 -0.9997 3063404 Maybridge4_001924 COc1ncnc(OC)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H11 compound treatment 126360.0 -29900.0 -1.16 122200.0 -30700.0 -1.15 -1.6341 -1.0 1558852 Maybridge4_001925 CC1=C(C(C2=C(N1)c3ccccc3C2=O)c4ccccc4)C(=O)Nc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H12 compound treatment 160000.0 3760.0 0.15 159520.0 6640.0 0.25 0.2793 0.9674 1698244 Maybridge4_001926 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H13 compound treatment 146280.0 -9960.0 -0.39 148440.0 -4440.0 -0.17 -0.3912 -0.9292 1372400 Maybridge4_001927 O=c1c(c[nH]c2ccccc12)c3nnnn3c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H14 compound treatment 154240.0 -2000.0 -0.08 140960.0 -11900.0 -0.45 -0.3713 -0.8177 3179497 Maybridge4_001928 N1[C@H]([C@H](N=C1c2ccccc2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H15 compound treatment 149760.0 -6480.0 -0.25 150640.0 -2240.0 -0.08 -0.2373 -0.8948 3063405 Maybridge4_001929 CO[C@H]1O[C@H](COC(=O)c2ccccc2)[C@@H](O)[C@H](O)[C@H]1OC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H16 compound treatment 137600.0 -18600.0 -0.72 149760.0 -3120.0 -0.12 -0.5943 -0.811 1081881 Maybridge4_001930 COC(=O)CSc1nc2ccccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H17 compound treatment 133000.0 -23200.0 -0.9 141760.0 -11100.0 -0.42 -0.9328 -0.9387 3063406 Maybridge4_001931 CC(C)N(C(C)C)C(=O)NCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H18 compound treatment 12920.0 -143000.0 -5.56 13840.0 -139000.0 -5.22 -7.6222 -0.9995 3179498 Maybridge4_001932 Clc1ccc(cc1)c2nc(SCc3ccccc3)[nH]c(=S)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H19 compound treatment 146120.0 -10100.0 -0.39 141600.0 -11300.0 -0.42 -0.5771 -0.9993 3063407 Maybridge4_001933 OC(=O)c1cc(F)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H20 compound treatment 136760.0 -19500.0 -0.76 171000.0 18100.0 0.68 -0.0537 -0.0528 1198061 Maybridge4_001934 CC(Oc1ccc(Cl)cc1Cl)c2n[nH]c(=S)n2CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H21 compound treatment 173080.0 16800.0 0.65 163480.0 10600.0 0.4 0.7432 0.9717 3179499 Maybridge4_001935 FC(F)(F)C(NC1CCCCC1)(NC(=O)c2ccccc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H22 compound treatment 77920.0 -78300.0 -3.04 100760.0 -52100.0 -1.96 -3.5321 -0.9773 1345621 Maybridge4_001936 O=c1[nH][nH]c(=O)n1CCCc2cc3cccc4ccc5cccc2c5c43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H23 mock treatment 163240.0 7000.0 0.27 142160.0 -10700.0 -0.4 -0.0926 -0.1907 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 H24 mock treatment 146560.0 -9680.0 -0.38 144760.0 -8120.0 -0.3 -0.4812 -0.9946 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I01 compound treatment 134640.0 -21600.0 -0.84 170000.0 17100.0 0.64 -0.1384 -0.131 3179500 Maybridge4_001937 NC(=O)c1ccccc1NCC(=O)c2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I02 compound treatment 139000.0 -17200.0 -0.67 169160.0 16300.0 0.61 -0.041 -0.0453 1786031 Maybridge4_001938 S=c1[nH]nc(Cc2ccccc2)n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I03 compound treatment 148640.0 -7600.0 -0.3 146680.0 -6200.0 -0.23 -0.3732 -0.9931 1416652 Maybridge4_001939 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I04 compound treatment 179320.0 23100.0 0.9 155040.0 2160.0 0.08 0.6904 0.768 3179586 Maybridge4_001940 CNC(=O)NC(=O)CSc1nnc(Cc2ccccc2)n1c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I05 compound treatment 271640.0 115000.0 4.48 153240.0 360.0 0.01 3.1756 0.7092 3063409 Maybridge4_001941 Cn1cc(cn1)S(=O)(=O)Nc2ccc(Oc3c(Cl)cccc3Cl)nc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I06 compound treatment 152000.0 -4240.0 -0.16 155560.0 2680.0 0.1 -0.0453 -0.2348 3179587 Maybridge4_001942 Clc1ccccc1CC(C(=O)N2CCc3ccccc23)C(=O)N4CCc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I07 compound treatment 159000.0 2760.0 0.11 176080.0 23200.0 0.87 0.6913 0.788 3063410 Maybridge4_001943 CCOC(=O)c1cnn(C(=O)c2ccc(cc2)n3c(C)ccc3C)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I08 compound treatment 198160.0 41900.0 1.63 157360.0 4480.0 0.17 1.2689 0.7761 1500802 Maybridge4_001944 NC(=O)c1nnc2ccc(Cl)cc2c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I09 compound treatment 141760.0 -14500.0 -0.56 145680.0 -7200.0 -0.27 -0.5885 -0.9437 1103360 Maybridge4_001945 FC(F)(F)c1ccc(cc1)C(=O)CN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I10 compound treatment 137920.0 -18300.0 -0.71 148040.0 -4840.0 -0.18 -0.6312 -0.8601 3179588 Maybridge4_001946 O=C(CSc1nnc2NCCCn12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I11 compound treatment 157000.0 756.0 0.03 157960.0 5080.0 0.19 0.1556 0.8064 1721477 Maybridge4_001947 Cc1nn(c2NC3=C(C(c12)c4cccnc4)C(=O)CC(C)(C)C3)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I12 compound treatment 168320.0 12100.0 0.47 172920.0 20000.0 0.75 0.8632 0.9741 1444715 Maybridge4_001948 Cc1nc2cc(C)ccn2c1c3nnco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I13 compound treatment 148920.0 -7320.0 -0.28 144080.0 -8800.0 -0.33 -0.4345 -0.9972 3063411 Maybridge4_001949 Cc1cc(C)c(C#N)c(Sc2ncnc3c2sc4nc(C)cc(C)c43)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I14 compound treatment 150520.0 -5720.0 -0.22 163320.0 10400.0 0.39 0.12 0.2665 3179589 Maybridge4_001950 COc1ccc(cc1)n2c(n[nH]c2=S)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I15 compound treatment 135120.0 -21100.0 -0.82 148440.0 -4440.0 -0.17 -0.6974 -0.8338 3179590 Maybridge4_001951 CNC(=S)N1N=C2C(CCc3ccccc23)C1c4ccc(OC)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I16 compound treatment 141360.0 -14900.0 -0.58 142400.0 -10500.0 -0.39 -0.6865 -0.9825 3063412 Maybridge4_001952 CCOC(=O)N1CCc2c(C1)sc3[nH]c(=S)n(c4ccccc4)c(=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I17 compound treatment 146240.0 -10000.0 -0.39 187240.0 34400.0 1.29 0.6374 0.4733 3179591 Maybridge4_001953 COc1cc2CCn3c(C(=O)c4cccs4)c(c(C#N)c3-c2cc1OC)c5ccc(C)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I18 compound treatment 146320.0 -9920.0 -0.39 149200.0 -3680.0 -0.14 -0.3699 -0.9043 3063413 Maybridge4_001954 Fc1ccc(CN2C(=O)/C(=C\c3ccc(F)cc3)/N=C2c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I19 compound treatment 136960.0 -19300.0 -0.75 168400.0 15500.0 0.58 -0.1172 -0.1236 3179592 Maybridge4_001955 CCC(C)[C@H](NC(=O)c1ccco1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I20 compound treatment 131880.0 -24400.0 -0.95 143160.0 -9720.0 -0.36 -0.9264 -0.9143 3179593 Maybridge4_001956 COc1cccc(c1)C(=O)c2sc3nsc(SCc4ccccc4)c3c2N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I21 compound treatment 135320.0 -20900.0 -0.81 142720.0 -10200.0 -0.38 -0.8437 -0.9406 3063414 Maybridge4_001957 Cc1cc(C)c2c(N)c(sc2n1)c3nnc(SCC(=O)c4ccccc4)n3CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I22 compound treatment 134480.0 -21800.0 -0.84 135080.0 -17800.0 -0.67 -1.0695 -0.9933 3179594 Maybridge4_001958 C=CCn1nc2CSc3ccccc3-n2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I23 mock treatment 139800.0 -16400.0 -0.64 167960.0 15100.0 0.57 -0.0509 -0.0597 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 I24 mock treatment 153880.0 -2360.0 -0.09 140000.0 -12900.0 -0.48 -0.4067 -0.8265 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J01 compound treatment 119200.0 -37000.0 -1.44 173040.0 20200.0 0.76 -0.4813 -0.2963 3179595 Maybridge4_001959 CCOC(=O)CSc1nc(CN2c3ccccc3Sc4ccccc24)n[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J02 compound treatment 181680.0 25400.0 0.99 165240.0 12400.0 0.46 1.0259 0.9407 1402836 Maybridge4_001960 NS(=O)(=O)c1ccc(Cl)cc1Sc2ccccc2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J03 compound treatment 109160.0 -47100.0 -1.83 116040.0 -36800.0 -1.38 -2.2695 -0.9906 3179596 Maybridge4_001961 CCOC(=O)Cn1c(nc(c1c2ccccc2)c3ccccc3)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J04 compound treatment 147960.0 -8280.0 -0.32 148080.0 -4800.0 -0.18 -0.3547 -0.9626 1114912 Maybridge4_001962 NNC(=O)CNC(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J05 compound treatment 174400.0 18200.0 0.7 198000.0 45100.0 1.69 1.6956 0.9245 3179597 Maybridge4_001963 Fc1ccc(COc2nc(cc(c3ccco3)c2C#N)c4cccs4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J06 compound treatment 155120.0 -1120.0 -0.04 150440.0 -2440.0 -0.09 -0.0956 -0.9424 3063348 Maybridge4_001964 FC(F)(F)C(NCc1ccccn1)(NC(=O)c2cccnc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J07 compound treatment 61120.0 -95100.0 -3.69 41200.0 -112000.0 -4.19 -5.5737 -0.998 3179598 Maybridge4_001965 COc1ccc(/N=C/c2cn(cc2\C=N\c3ccc(OC)cc3)c4ccc(OC)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J08 compound treatment 11800.0 -144000.0 -5.6 12360.0 -141000.0 -5.27 -7.6922 -0.9995 1550362 Maybridge4_001966 OC(=O)c1ccccc1NC(=O)OCC2c3ccccc3-c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J09 compound treatment 12520.0 -144000.0 -5.58 13080.0 -140000.0 -5.25 -7.6533 -0.9995 3179599 Maybridge4_001967 CC1(C)CC(=O)C=C(C1)Sc2nc3cc(Cl)ccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J10 compound treatment 140280.0 -16000.0 -0.62 150040.0 -2840.0 -0.11 -0.5134 -0.8168 1156147 Maybridge4_001968 COc1ccc2nc3n(C)c(=O)n(C)c(=O)c3cc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J11 compound treatment 29800.0 -126000.0 -4.91 37200.0 -116000.0 -4.34 -6.5391 -0.9981 3179600 Maybridge4_001969 O=C1C2=C(NC(=S)NC2c3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J12 compound treatment 139840.0 -16400.0 -0.64 152400.0 -480.0 -0.02 -0.4628 -0.7268 1727811 Maybridge4_001970 COc1cc(CCC(C)NC(=O)c2ccco2)ccc1OC(=O)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J13 compound treatment 138200.0 -18000.0 -0.7 159480.0 6600.0 0.25 -0.3199 -0.4308 3063350 Maybridge4_001971 COc1ccc(C#N)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J14 compound treatment 164000.0 7760.0 0.3 155720.0 2840.0 0.11 0.2882 0.9026 1014022 Maybridge4_001972 O=S(=O)(Cc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J15 compound treatment 134320.0 -21900.0 -0.85 152240.0 -640.0 -0.02 -0.6185 -0.7268 3179601 Maybridge4_001973 Nc1n/c(=N\c2ccccc2)/n(c3ccccc3)c(=N)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J16 compound treatment 142120.0 -14100.0 -0.55 182920.0 30000.0 1.13 0.4097 0.3268 3063351 Maybridge4_001974 FC(F)(F)c1ccccc1/N=C/2\CCCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J17 compound treatment 136560.0 -19700.0 -0.76 155000.0 2120.0 0.08 -0.4838 -0.63 3179602 Maybridge4_001975 COCOc1ccc(cc1OC)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J18 compound treatment 153000.0 -3240.0 -0.13 181360.0 28500.0 1.07 0.6668 0.6196 1465673 Maybridge4_001976 CC(Nc1ccccc1)(C#N)c2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J19 compound treatment 117880.0 -38400.0 -1.49 135000.0 -17900.0 -0.67 -1.5271 -0.9352 3179603 Maybridge4_001977 c1ccc(cc1)c2nnc(o2)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J20 compound treatment 135000.0 -21200.0 -0.82 139160.0 -13700.0 -0.51 -0.947 -0.9743 1519121 Maybridge4_001978 CC(Oc1ccccc1c2ccccc2)c3n[nH]c(=S)n3c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J21 compound treatment 138040.0 -18200.0 -0.71 167960.0 15100.0 0.57 -0.0992 -0.1096 3063353 Maybridge4_001979 COC(NC(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J22 compound treatment 154400.0 -1840.0 -0.07 144280.0 -8600.0 -0.32 -0.2788 -0.8434 1009264 Maybridge4_001980 CC(NC(=O)C)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J23 mock treatment 147800.0 -8440.0 -0.33 152760.0 -120.0 0.0 -0.2348 -0.7168 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 J24 mock treatment 160560.0 4320.0 0.17 149640.0 -3240.0 -0.12 0.0324 0.1567 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K01 compound treatment 143840.0 -12400.0 -0.48 159560.0 6680.0 0.25 -0.163 -0.3004 3179604 Maybridge4_001981 OC(=O)CSCC(=O)N1CCCN(CC1)c2ccc(cn2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K02 compound treatment 139640.0 -16600.0 -0.64 149240.0 -3640.0 -0.14 -0.5521 -0.8384 3063380 Maybridge4_001982 CCOC(=O)c1nnn2c1nc(SCC(=O)N)c3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K03 compound treatment 139400.0 -16800.0 -0.65 140680.0 -12200.0 -0.46 -0.7859 -0.9849 3179605 Maybridge4_001983 COc1ccc(NC(=O)c2ccc(CN3CCS(=O)(=O)CC3)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K04 compound treatment 167360.0 11100.0 0.43 163440.0 10600.0 0.4 0.5852 0.9991 3063381 Maybridge4_001984 CNC(=O)NC(=O)CSc1nnc(c2ccncc2)n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K05 compound treatment 135680.0 -20600.0 -0.8 143800.0 -9080.0 -0.34 -0.8052 -0.928 3179606 Maybridge4_001985 S=C(NCC1CC(=NO1)c2ccccc2)NCc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K06 compound treatment 146880.0 -9360.0 -0.36 153880.0 1000.0 0.04 -0.2304 -0.6307 3179607 Maybridge4_001986 CCOc1nc-2c(Cc3ccccc32)c(c4ccco4)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K07 compound treatment 132720.0 -23500.0 -0.91 146520.0 -6360.0 -0.24 -0.8142 -0.863 3063383 Maybridge4_001987 Sc1nnc(Cc2ccsc2)n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K08 compound treatment 143080.0 -13200.0 -0.51 155040.0 2160.0 0.08 -0.3038 -0.5875 3179608 Maybridge4_001988 O=c1[nH]c-2c(CCc3ccccc32)c(c1C#N)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K09 compound treatment 55920.0 -100000.0 -3.89 64320.0 -88600.0 -3.32 -5.1028 -0.9969 3063384 Maybridge4_001989 C=CCSc1c2CCCc2c(C#N)c3nc4ccccc4n13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K10 compound treatment 133760.0 -22500.0 -0.87 151520.0 -1360.0 -0.05 -0.653 -0.7472 3179609 Maybridge4_001990 O=C(N1CCCn2c(SCc3ccccc3)nnc12)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K11 compound treatment 177080.0 20800.0 0.81 164120.0 11200.0 0.42 0.87 0.954 3063386 Maybridge4_001991 CCNC(=S)Nc1sc2CC(C)CCc2c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K12 compound treatment 145080.0 -11200.0 -0.43 158400.0 5520.0 0.21 -0.1598 -0.3328 3179610 Maybridge4_001992 Cc1sc2nc3SCC(=Nn3c(=O)c2c1C)c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K13 compound treatment 146680.0 -9560.0 -0.37 164960.0 12100.0 0.45 0.0582 0.0993 3063387 Maybridge4_001993 CCOC(=O)c1oc2nc(cc(c3ccco3)c2c1N)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K14 compound treatment 144960.0 -11300.0 -0.44 145960.0 -6920.0 -0.26 -0.4932 -0.9689 3179611 Maybridge4_001994 C1Sc2ccccc2-n3c(nnc13)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K15 compound treatment 145520.0 -10700.0 -0.42 156640.0 3760.0 0.14 -0.1944 -0.4425 3179694 Maybridge4_001995 CCOC(=O)c1nnn2c1n(C)c(=O)c3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K16 compound treatment 142080.0 -14200.0 -0.55 167840.0 15000.0 0.56 0.0084 0.0107 3063389 Maybridge4_001996 O=c1c(nnc2sc3ccccc3n12)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K17 compound treatment 134160.0 -22100.0 -0.86 140160.0 -12700.0 -0.48 -0.9435 -0.9619 3179695 Maybridge4_001997 CCOC(=O)C1=NN(C2C1c3cccc4cccc2c34)c5ccc(C)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K18 compound treatment 126400.0 -29800.0 -1.16 136960.0 -15900.0 -0.6 -1.2413 -0.9526 3063390 Maybridge4_001998 Clc1ccccc1/C=C\2/N=C(N(CC=C)C2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K19 compound treatment 118040.0 -38200.0 -1.48 122160.0 -30700.0 -1.15 -1.8634 -0.9923 3179696 Maybridge4_001999 O=C(NCC1COc2ccccc2O1)Nc3csc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K20 compound treatment 156120.0 -124.0 0.0 178320.0 25400.0 0.95 0.6718 0.7035 3179697 Maybridge4_002000 CNC(=O)NC(=O)CSc1ncnc2sc(cc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K21 compound treatment 172200.0 16000.0 0.62 164640.0 11800.0 0.44 0.7499 0.9862 3063391 Maybridge4_002001 Cc1cc(C)c2c(N)c(sc2n1)c3nnc(SCc4ccc(Cl)cc4)n3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K22 compound treatment 122280.0 -34000.0 -1.32 180840.0 28000.0 1.05 -0.1898 -0.1127 3179698 Maybridge4_002002 S=c1[nH]nc(CSc2nc(cn2c3ccccc3)c4ccccc4)n1c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K23 mock treatment 142480.0 -13800.0 -0.53 157840.0 4960.0 0.19 -0.246 -0.435 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 K24 mock treatment 144560.0 -11700.0 -0.45 151640.0 -1240.0 -0.05 -0.3535 -0.7756 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L01 compound treatment 121440.0 -34800.0 -1.35 157200.0 4320.0 0.16 -0.8402 -0.6178 3063422 Maybridge4_002003 CCOC(=O)CSc1nc(SCC(=O)OCC)c2c3CCCc3sc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L02 compound treatment 140240.0 -16000.0 -0.62 156800.0 3920.0 0.15 -0.335 -0.525 1536081 Maybridge4_002004 OC(=O)c1ccccc1Sc2ccccc2S(=O)(=O)NC3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L03 compound treatment 55120.0 -101000.0 -3.92 66840.0 -86000.0 -3.23 -5.0578 -0.9953 3179699 Maybridge4_002005 C=CCn1c(nc(c1c2ccccc2)c3ccccc3)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L04 compound treatment 128960.0 -27300.0 -1.06 144440.0 -8440.0 -0.32 -0.9725 -0.8801 1430538 Maybridge4_002006 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L05 compound treatment 98360.0 -57900.0 -2.25 114560.0 -38300.0 -1.44 -2.6051 -0.9768 3179700 Maybridge4_002007 N=c1n(Nc2ccccc2)cnc3sc4CCCc4c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L06 compound treatment 178360.0 22100.0 0.86 163720.0 10800.0 0.41 0.8945 0.9419 3063426 Maybridge4_002008 Cc1ccc(cc1)C(=O)NC(NCc2ccco2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L07 compound treatment 125880.0 -30400.0 -1.18 168560.0 15700.0 0.59 -0.4169 -0.3166 3179701 Maybridge4_002009 Brc1ccc(s1)c2ccc(Br)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L08 compound treatment 163840.0 7600.0 0.29 177480.0 24600.0 0.92 0.8613 0.8887 1371799 Maybridge4_002010 CCOC(=O)C(C)Oc1ccc2c(cc(=O)oc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L09 compound treatment 157640.0 1400.0 0.05 148760.0 -4120.0 -0.15 -0.071 -0.4336 1134767 Maybridge4_002011 C1C(=Cc2ccccc12)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L10 compound treatment 138240.0 -18000.0 -0.7 167320.0 14400.0 0.54 -0.1107 -0.1252 1364288 Maybridge4_002012 O=C(NC1CCN(CC1)C(=O)C2CCC2)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L11 compound treatment 136560.0 -19700.0 -0.76 160120.0 7240.0 0.27 -0.3479 -0.4292 1570440 Maybridge4_002013 Oc1cc(Cc2ccccc2)cnc1CN3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L12 compound treatment 18000.0 -138000.0 -5.36 21880.0 -131000.0 -4.92 -7.2694 -0.9991 1227426 Maybridge4_002014 CC(C)C1CCC(C)CC1N(Cc2ccccc2)C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L13 compound treatment 156120.0 -124.0 0.0 151160.0 -1720.0 -0.06 -0.049 -0.7577 1583701 Maybridge4_002015 N[C@@H](CO)CSCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L14 compound treatment 141520.0 -14700.0 -0.57 146760.0 -6120.0 -0.23 -0.5664 -0.9198 1368346 Maybridge4_002016 COc1cc(CCc2cc(OC)c(C)cc2OC)c(OC)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L15 compound treatment 105320.0 -50900.0 -1.98 147960.0 -4920.0 -0.18 -1.5277 -0.7698 3063428 Maybridge4_002017 FC(F)(F)C(NC(=O)c1ccccc1)(Nc2ccccc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L16 compound treatment 95400.0 -60800.0 -2.36 101880.0 -51000.0 -1.91 -3.0228 -0.9946 1023708 Maybridge4_002018 COc1ccc(cc1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L17 compound treatment 141080.0 -15200.0 -0.59 166560.0 13700.0 0.51 -0.053 -0.0678 1344186 Maybridge4_002019 CC(=O)N1C(C(=O)NC1=S)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L18 compound treatment 143960.0 -12300.0 -0.48 137960.0 -14900.0 -0.56 -0.733 -0.9968 3179703 Maybridge4_002020 CC(C)C(C)(Nc1ccccc1)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L19 compound treatment 138400.0 -17800.0 -0.69 169360.0 16500.0 0.62 -0.0522 -0.0562 1047316 Maybridge4_002021 OC(=O)c1ccc(s1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L20 compound treatment 123200.0 -33000.0 -1.28 126640.0 -26200.0 -0.98 -1.603 -0.9915 3179704 Maybridge4_002022 Brc1ccccc1C(=O)c2ccc-3c(c2)C(=O)c4ccccc43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L21 compound treatment 132160.0 -24100.0 -0.93 138280.0 -14600.0 -0.55 -1.0482 -0.9677 3063451 Maybridge4_002023 FC(F)(F)C(NC(=O)c1ccccc1)(OCc2ccccc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L22 compound treatment 138640.0 -17600.0 -0.68 154480.0 1600.0 0.06 -0.4405 -0.6425 3179705 Maybridge4_002024 CCOC(=O)CSc1nncc(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L23 mock treatment 150440.0 -5800.0 -0.23 132240.0 -20600.0 -0.77 -0.707 -0.8764 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 L24 mock treatment 142120.0 -14100.0 -0.55 160160.0 7280.0 0.27 -0.1943 -0.3173 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M01 compound treatment 139600.0 -16600.0 -0.65 173840.0 21000.0 0.79 0.0996 0.0979 3063453 Maybridge4_002025 Cc1ccc(CNC(=O)Nc2ccccc2)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M02 compound treatment 158640.0 2400.0 0.09 166440.0 13600.0 0.51 0.4256 0.8227 3179706 Maybridge4_002026 CCOC(=O)c1nnn2c1nc(SCc3ccc(F)cc3)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M03 compound treatment 123640.0 -32600.0 -1.27 120800.0 -32100.0 -1.2 -1.7459 -0.9997 3179707 Maybridge4_002027 O=C(Nc1ccc(OCc2ccccc2)cc1)OCC3CN(Cc4ccccc4)CCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M04 compound treatment 135600.0 -20600.0 -0.8 139880.0 -13000.0 -0.49 -0.9114 -0.9717 3063456 Maybridge4_002028 O=C(CC(C(=O)N1CCc2ccccc12)C(=O)N3CCc4ccccc34)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M05 compound treatment 174560.0 18300.0 0.71 154240.0 1360.0 0.05 0.5386 0.7559 3179708 Maybridge4_002029 O=C(OCC1CC(=NO1)c2ccccc2)c3cccc(n3)C(=O)OCC4CC(=NO4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M06 compound treatment 140520.0 -15700.0 -0.61 151400.0 -1480.0 -0.06 -0.4707 -0.7683 3063457 Maybridge4_002030 CC1=Nn2c(Cn3nnc4ccccc34)nnc2SC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M07 compound treatment 130280.0 -26000.0 -1.01 169160.0 16300.0 0.61 -0.2803 -0.2379 3179709 Maybridge4_002031 C/C(=N\O)/C(C)(C)Nc1ccc(cc1)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M08 compound treatment 12720.0 -144000.0 -5.57 23880.0 -129000.0 -4.84 -7.3612 -0.9976 3063458 Maybridge4_002032 O=C(Oc1cc(=O)oc2c3cccc4CCn(c(=O)c12)c43)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M09 compound treatment 142880.0 -13400.0 -0.52 166200.0 13300.0 0.5 -0.0132 -0.0183 2096080 Maybridge4_002033 CCOC(=O)c1sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c2c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M10 compound treatment 112640.0 -43600.0 -1.69 116880.0 -36000.0 -1.35 -2.1517 -0.9938 3179710 Maybridge4_002034 CCOC(=O)N1CCc2c(C#N)c(NC(=O)CN3CCc4ccccc34)sc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M11 compound treatment 171640.0 15400.0 0.6 198120.0 45200.0 1.7 1.623 0.9017 3063459 Maybridge4_002035 O=C(COc1nc(cc(c2cccs2)c1C#N)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M12 compound treatment 147480.0 -8760.0 -0.34 173160.0 20300.0 0.76 0.2978 0.3572 3063460 Maybridge4_002036 O=c1n(CN2CCOCC2)nc3sc4ccccc4n3c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M13 compound treatment 156960.0 716.0 0.03 180280.0 27400.0 1.03 0.7468 0.7259 3179711 Maybridge4_002037 Nc1c(oc2nc(cc(c3cccs3)c12)c4ccco4)C(=O)c5ccc(Cl)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M14 compound treatment 11960.0 -144000.0 -5.6 16280.0 -137000.0 -5.13 -7.5838 -0.999 3063486 Maybridge4_002038 Cc1nc2n(ncc2c(=O)n1NC(=O)Nc3ccc(Cl)c(Cl)c3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M15 compound treatment 139600.0 -16600.0 -0.65 151200.0 -1680.0 -0.06 -0.5012 -0.7725 3179712 Maybridge4_002039 CCOC(=O)c1nnn2c1n(CC=C)c(=O)c3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M16 compound treatment 131440.0 -24800.0 -0.96 144840.0 -8040.0 -0.3 -0.8939 -0.8863 3063487 Maybridge4_002040 COC(=O)C1=C(C)N=C2SC(=C(N)N2C1c3cccs3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M17 compound treatment 63160.0 -93100.0 -3.61 123200.0 -29700.0 -1.11 -3.3415 -0.8841 3179713 Maybridge4_002041 O=C/1NN=C(\C1=C\2/OC(=CS2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M18 compound treatment 122760.0 -33500.0 -1.3 158240.0 5360.0 0.2 -0.7764 -0.5906 3179714 Maybridge4_002042 Clc1ccc(CN2C(=O)/C(=C\c3cccs3)/N=C2c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M19 compound treatment 139920.0 -16300.0 -0.63 153320.0 440.0 0.02 -0.4362 -0.6884 3063489 Maybridge4_002043 COc1ccc(cc1)n2ncc(NC(=O)N3CCOCC3)c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M20 compound treatment 155960.0 -284.0 -0.01 142680.0 -10200.0 -0.38 -0.2785 -0.7272 3179715 Maybridge4_002044 O=c1c(nc(nn1CN2CCOCC2)c3ccccc3)C(CN4CCOCC4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M21 compound treatment 129720.0 -26500.0 -1.03 140560.0 -12300.0 -0.46 -1.0547 -0.9348 3063490 Maybridge4_002045 Clc1ccccc1C2C3CCc4ccccc4C3=NN2C(=O)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M22 compound treatment 119280.0 -37000.0 -1.43 141400.0 -11500.0 -0.43 -1.3188 -0.8807 3179716 Maybridge4_002046 CCOC(=O)c1cnc(nc1N)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M23 mock treatment 150960.0 -5280.0 -0.21 154600.0 1720.0 0.06 -0.0993 -0.4621 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 M24 mock treatment 148840.0 -7400.0 -0.29 145320.0 -7560.0 -0.28 -0.4038 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N01 compound treatment 175720.0 19500.0 0.76 168520.0 15600.0 0.59 0.9494 0.9922 3063492 Maybridge4_002047 O=C1CSc2nnc(c3ccccc3)n12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N02 compound treatment 119400.0 -36800.0 -1.43 156000.0 3120.0 0.12 -0.928 -0.647 1229835 Maybridge4_002048 OC(=O)c1ccccc1Sc2ccccc2S(=O)(=O)NC3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N03 compound treatment 128000.0 -28200.0 -1.1 166640.0 13800.0 0.52 -0.4097 -0.3382 1256899 Maybridge4_002049 c1csc(c1)c2nc(c([nH]2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N04 compound treatment 42280.0 -114000.0 -4.42 84440.0 -68400.0 -2.57 -4.943 -0.9666 3178130 Maybridge4_002050 CCCc1cc(O)nc(SC/C=C/c2ccccc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N05 compound treatment 140080.0 -16200.0 -0.63 156080.0 3200.0 0.12 -0.3585 -0.5615 3178131 Maybridge4_002051 CCNc1nc(SCC(=O)NC(=O)NCc2ccccc2)nc3sc4CN(C)CCc4c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N06 compound treatment 11160.0 -145000.0 -5.63 23720.0 -129000.0 -4.85 -7.4083 -0.9972 3063494 Maybridge4_002052 CC1CN=C(S1)N(C2CCCCC2)C(=O)Nc3cccc(Cl)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N07 compound treatment 83720.0 -72500.0 -2.81 131680.0 -21200.0 -0.8 -2.5524 -0.8728 3178132 Maybridge4_002053 Cc1ccc(OC(=O)OCSc2nnn[nH]2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N08 compound treatment 151360.0 -4880.0 -0.19 169160.0 16300.0 0.61 0.2981 0.4659 1423044 Maybridge4_002054 CC(Oc1ccc2c(cc(=O)oc2c1)c3ccccc3)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N09 compound treatment 145040.0 -11200.0 -0.43 144720.0 -8160.0 -0.31 -0.5239 -0.9853 1177114 Maybridge4_002055 Brc1ccc(cc1)N2C(=O)C3=C(C2=O)C(=NCCN3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N10 compound treatment 140880.0 -15400.0 -0.6 149480.0 -3400.0 -0.13 -0.5118 -0.8395 1659522 Maybridge4_002056 Clc1cccc(Cl)c1C(=O)N2CCC(CC2)NC(=O)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N11 compound treatment 133120.0 -23100.0 -0.9 151120.0 -1760.0 -0.07 -0.6811 -0.7571 1381385 Maybridge4_002057 CN1C(=O)N(c2ccc(Cl)cc2)C(C)(O)CC1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N12 compound treatment 136720.0 -19500.0 -0.76 126440.0 -26400.0 -0.99 -1.2373 -0.9911 1409714 Maybridge4_002058 COc1cccc(NC(=O)c2ccc(OC)c(OC)c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N13 compound treatment 130680.0 -25600.0 -0.99 136080.0 -16800.0 -0.63 -1.1472 -0.9761 1704266 Maybridge4_002059 CC(C)(C)C(=O)Nc1ccccc1Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N14 compound treatment 156320.0 76.1 0.0 144040.0 -8840.0 -0.33 -0.2325 -0.7008 3178133 Maybridge4_002060 NNC(=O)c1cc(S)ncn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N15 compound treatment 126240.0 -30000.0 -1.16 151000.0 -1880.0 -0.07 -0.8731 -0.7486 3063524 Maybridge4_002061 CC(=O)NC(Nc1ccccc1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N16 compound treatment 134680.0 -21600.0 -0.84 208040.0 55200.0 2.07 0.8723 0.3906 3178134 Maybridge4_002062 C/C(=N\c1ccccc1C(F)(F)F)/c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N17 compound treatment 132360.0 -23900.0 -0.93 155040.0 2160.0 0.08 -0.598 -0.6428 1020871 Maybridge4_002063 O=C1NC(C(=O)N1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N18 compound treatment 125800.0 -30400.0 -1.18 167360.0 14500.0 0.54 -0.451 -0.3468 1667495 Maybridge4_002064 Clc1ccc2[nH]c(=O)c3nc(oc3c2c1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N19 compound treatment 142560.0 -13700.0 -0.53 137040.0 -15800.0 -0.59 -0.7958 -0.9984 1670169 Maybridge4_002065 CC(C)c1ccc(cc1)S(=O)(=O)CC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N20 compound treatment 134840.0 -21400.0 -0.83 137840.0 -15000.0 -0.56 -0.9864 -0.9823 1596128 Maybridge4_002066 CCOC(=O)C1CCN(C1=O)S(=O)(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N21 compound treatment 120360.0 -35900.0 -1.39 135880.0 -17000.0 -0.64 -1.4357 -0.9374 1008385 Maybridge4_002067 O=C(c1ccccc1)c2ccccc2C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N22 compound treatment 142960.0 -13300.0 -0.52 145960.0 -6920.0 -0.26 -0.5481 -0.9497 1546853 Maybridge4_002068 Cn1c(=O)n(C)c2ncn(CC(O)CN(CC=C)CC=C)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N23 mock treatment 141720.0 -14500.0 -0.56 139200.0 -13700.0 -0.51 -0.7615 -0.9989 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 N24 mock treatment 154920.0 -1320.0 -0.05 157280.0 4400.0 0.17 0.0804 0.4652 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O01 compound treatment 115400.0 -40800.0 -1.58 118040.0 -34800.0 -1.31 -2.0452 -0.9954 3063527 Maybridge4_002069 O=C(Nc1sccc1c2nc3ccccc3s2)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O02 compound treatment 156840.0 596.0 0.02 149840.0 -3040.0 -0.11 -0.0643 -0.5525 3178135 Maybridge4_002070 CCOC(=O)CSc1nnc(Cn2nnc3ccccc23)n1c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O03 compound treatment 139600.0 -16600.0 -0.65 145440.0 -7440.0 -0.28 -0.6541 -0.9297 3063528 Maybridge4_002071 Cc1ccc(cc1)S(=O)(=O)NC(=O)OCC2CN(Cc3ccccc3)CCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O04 compound treatment 170720.0 14500.0 0.56 172520.0 19600.0 0.74 0.9184 0.991 3178136 Maybridge4_002072 Cn1nc2c3ccccc3n(CC=C)c2nc1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O05 compound treatment 23760.0 -132000.0 -5.14 54000.0 -98900.0 -3.71 -6.259 -0.9872 3178137 Maybridge4_002073 Clc1ccc(cc1)n2ncc(n2)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O06 compound treatment 133520.0 -22700.0 -0.88 191080.0 38200.0 1.43 0.3903 0.2319 3178138 Maybridge4_002074 Brc1ccc(cc1)C2=Nn3c(Cn4nnc5ccccc45)nnc3SC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O07 compound treatment 119880.0 -36400.0 -1.41 128440.0 -24400.0 -0.92 -1.6463 -0.9783 1760428 Maybridge4_002075 O=C(Nc1ccc2OCCOc2c1)c3ccc4nccnc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O08 compound treatment 132840.0 -23400.0 -0.91 157280.0 4400.0 0.17 -0.5253 -0.5692 3178139 Maybridge4_002076 CNC(=O)NC(=O)CSc1nnc(o1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O09 compound treatment 128720.0 -27500.0 -1.07 153040.0 160.0 0.01 -0.7509 -0.7031 3178140 Maybridge4_002077 CCOC(=O)COc1c(C#N)sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O10 compound treatment 145960.0 -10300.0 -0.4 159080.0 6200.0 0.23 -0.1176 -0.2546 3063548 Maybridge4_002078 S=c1[nH]c(=S)c2cnc(nc2[nH]1)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O11 compound treatment 168360.0 12100.0 0.47 165200.0 12300.0 0.46 0.6594 1.0 1200067 Maybridge4_002079 Cc1cc(C)c2c(N)c(sc2n1)C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O12 compound treatment 141960.0 -14300.0 -0.55 152000.0 -880.0 -0.03 -0.4152 -0.7479 2102976 Maybridge4_002080 COc1ccc(cc1)C2=Nn3c(SC2)nc4sc5CCCCc5c4c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O13 compound treatment 10920.0 -145000.0 -5.64 13640.0 -139000.0 -5.23 -7.6824 -0.9993 3063550 Maybridge4_002081 Cc1cc(C)c(C#N)c(Sc2ncnc3n(Cc4ccccc4)nnc23)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O14 compound treatment 123920.0 -32300.0 -1.25 182760.0 29900.0 1.12 -0.0939 -0.0558 3178141 Maybridge4_002082 O=c1n(/N=C/c2cccs2)cnc3sc(cc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O15 compound treatment 127080.0 -29200.0 -1.13 159000.0 6120.0 0.23 -0.6377 -0.5523 3178142 Maybridge4_002083 CCOC(=O)c1nnn2c1n(Cc3ccc(Cl)cc3)c(=O)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O16 compound treatment 153760.0 -2480.0 -0.1 198120.0 45200.0 1.7 1.1325 0.6659 3063551 Maybridge4_002084 COc1cc(/C=N/n2c(C)nc3n(cnc3c2=O)c4ccccc4)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O17 compound treatment 155720.0 -524.0 -0.02 166800.0 13900.0 0.52 0.355 0.6791 3178143 Maybridge4_002085 O=c1nc2n(nc(c3ccccc3)n2c(c1C#N)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O18 compound treatment 98360.0 -57900.0 -2.25 131240.0 -21600.0 -0.81 -2.1624 -0.9054 3063552 Maybridge4_002086 C1Cc2ccccc2N1c3ncnc4sc(cc34)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O19 compound treatment 141120.0 -15100.0 -0.59 155480.0 2600.0 0.1 -0.3459 -0.5815 3178144 Maybridge4_002087 COc1ccc(cc1)n2ncc(NC(=O)Nc3ccc4OCCCOc4c3)c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O20 compound treatment 141880.0 -14400.0 -0.56 144320.0 -8560.0 -0.32 -0.6213 -0.9658 3063553 Maybridge4_002088 Nc1ncnc2nc(ncc12)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O21 compound treatment 128200.0 -28000.0 -1.09 145880.0 -7000.0 -0.26 -0.9552 -0.8533 3178145 Maybridge4_002089 CC(=O)N1N=C2C(CCc3ccccc23)C1c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O22 compound treatment 138200.0 -18000.0 -0.7 160720.0 7840.0 0.29 -0.287 -0.3779 3063554 Maybridge4_002090 Cc1cc(=O)n2ncnc2n1CC(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O23 mock treatment 168840.0 12600.0 0.49 153720.0 840.0 0.03 0.3679 0.7512 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 O24 mock treatment 171680.0 15400.0 0.6 163160.0 10300.0 0.39 0.6963 0.9774 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P01 compound treatment 152000.0 -4240.0 -0.16 161520.0 8640.0 0.32 0.1129 0.3103 1504248 Maybridge4_002091 C1Cc2ccccc2N1c3ncnc4n(ncc34)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P02 compound treatment 125040.0 -31200.0 -1.21 133280.0 -19600.0 -0.74 -1.3763 -0.9715 1485949 Maybridge4_002092 CC(CN1CCN(Cc2ccccc2)CC1)N(C(=O)c3ccc(cc3)C(C)(C)C)c4ccccn4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P03 compound treatment 113880.0 -42400.0 -1.64 129280.0 -23600.0 -0.89 -1.7886 -0.9579 3063615 Maybridge4_002093 O=C/1NNC(=N\C1=C/c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P04 compound treatment 148480.0 -7760.0 -0.3 138640.0 -14200.0 -0.53 -0.5909 -0.9632 3178146 Maybridge4_002094 Cn1cnnc1Sc2cc(C#N)c(C#N)cc2Sc3nncn3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P05 compound treatment 7280.0 -149000.0 -5.78 19400.0 -133000.0 -5.01 -7.6294 -0.9975 3063618 Maybridge4_002095 CCNc1nc(SCc2ccc(Cl)cc2)nc3sc4CN(C)CCc4c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P06 compound treatment 143200.0 -13000.0 -0.51 166760.0 13900.0 0.52 0.0105 0.0144 3178147 Maybridge4_002096 Cn1cnc(c1C#N)n2oo2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P07 compound treatment 154000.0 -2240.0 -0.09 156240.0 3360.0 0.13 0.0276 0.1802 1405262 Maybridge4_002097 O=C(NCc1ccccc1)NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P08 compound treatment 109960.0 -46300.0 -1.8 165200.0 12300.0 0.46 -0.9429 -0.5085 1585718 Maybridge4_002098 CCOC(=O)C(C)Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P09 compound treatment 136280.0 -20000.0 -0.77 164320.0 11400.0 0.43 -0.2441 -0.2756 3178148 Maybridge4_002099 COC(=O)/C(=C/C(=O)c1c(F)c(F)c(OC)c(F)c1F)/O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P10 compound treatment 159680.0 3440.0 0.13 165440.0 12600.0 0.47 0.4276 0.8729 1497616 Maybridge4_002100 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)C3CCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P11 compound treatment 139200.0 -17000.0 -0.66 196160.0 43300.0 1.62 0.681 0.3883 3178149 Maybridge4_002101 O=c1ccc2CCCCc2n1CCC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P12 compound treatment 114320.0 -41900.0 -1.63 137440.0 -15400.0 -0.58 -1.56 -0.9034 1054556 Maybridge4_002102 Cc1ccc(NS(=O)(=O)c2ccccc2)c(NS(=O)(=O)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P13 compound treatment 136760.0 -19500.0 -0.76 148840.0 -4040.0 -0.15 -0.6418 -0.8324 1043550 Maybridge4_002103 OC1CCN(Cc2ccccc2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P14 compound treatment 165440.0 9200.0 0.36 179520.0 26600.0 1.0 0.9593 0.9036 1240290 Maybridge4_002104 CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P15 compound treatment 141240.0 -15000.0 -0.58 146200.0 -6680.0 -0.25 -0.5889 -0.9291 3063648 Maybridge4_002105 CC(=O)NC(NCc1ccccc1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P16 compound treatment 140920.0 -15300.0 -0.59 144800.0 -8080.0 -0.3 -0.6349 -0.9512 3178234 Maybridge4_002106 CC(C)[C@H]1COC(=N1)c2cccc(n2)C3=N[C@H](CO3)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P17 compound treatment 142600.0 -13600.0 -0.53 156240.0 3360.0 0.13 -0.2852 -0.524 3063650 Maybridge4_002107 CC(O)/C=C/c1cccc[n+]1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P18 compound treatment 97440.0 -58800.0 -2.28 121360.0 -31500.0 -1.18 -2.4498 -0.9532 3178235 Maybridge4_002108 CCOC(=O)C1=C(C)N(C(=O)Oc2ccccc2)C(=NC1c3ccccc3)SC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P19 compound treatment 133440.0 -22800.0 -0.88 144240.0 -8640.0 -0.32 -0.8549 -0.9072 3063651 Maybridge4_002109 CN1C(=O)/C(=C\Nc2ccc(Cl)cc2)/C(=O)c3c1n(C)c(=O)n(C)c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P20 compound treatment 132320.0 -23900.0 -0.93 135800.0 -17100.0 -0.64 -1.1097 -0.9837 1466385 Maybridge4_002110 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OC)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P21 compound treatment 100040.0 -56200.0 -2.18 114040.0 -38800.0 -1.46 -2.5728 -0.9808 1646281 Maybridge4_002111 COc1cccc(c1)c2ncc(o2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P22 compound treatment 98760.0 -57500.0 -2.23 133040.0 -19800.0 -0.74 -2.1037 -0.8946 1592521 Maybridge4_002112 O=C(Nc1ccccc1)N(Cc2ccccc2)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P23 mock treatment 153960.0 -2280.0 -0.09 161400.0 8520.0 0.32 0.1635 0.4926 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2054 P24 mock treatment 154400.0 -1840.0 -0.07 146760.0 -6120.0 -0.23 -0.213 -0.8854 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A01 compound treatment 194720.0 43000.0 1.67 171920.0 20400.0 0.77 1.7208 0.9375 3178236 Maybridge4_002113 CCOC(=O)c1c(C)n[nH]c1/N=C/c2ccc(OC)c(OC)c2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A02 compound treatment 167200.0 15500.0 0.6 156920.0 5390.0 0.2 0.5677 0.8957 3178237 Maybridge4_002114 CS/C(=C(/C#N)\S(=O)(=O)c1ccc(Cl)cc1)/NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A03 compound treatment 186600.0 34900.0 1.35 151240.0 -295.0 -0.01 0.9492 0.7013 1739670 Maybridge4_002115 O=C(C(C(=O)N1CCCCC1)C2(CC3CC4CC(C3)C2)C4)N5CCCCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A04 compound treatment 173600.0 21900.0 0.85 156520.0 4990.0 0.19 0.7327 0.8427 3178238 Maybridge4_002116 CSc1c(C#N)c(nn1C)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A05 compound treatment 169720.0 18000.0 0.7 145200.0 -6340.0 -0.24 0.3258 0.4416 3063681 Maybridge4_002117 CN(C)c1nc(O)nc(n1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A06 compound treatment 199280.0 47600.0 1.85 149640.0 -1900.0 -0.07 1.2547 0.6794 3178239 Maybridge4_002118 CN1c2ccccc2C(=O)/C(=C\Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)/S1(=O)=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A07 compound treatment 162840.0 11100.0 0.43 155680.0 4150.0 0.16 0.4152 0.905 1532269 Maybridge4_002119 COc1cc2CCN=C(c3ccccc3NC(=O)c4cccc(Cl)c4)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A08 compound treatment 136680.0 -15000.0 -0.58 83600.0 -67900.0 -2.55 -2.2155 -0.847 1424615 Maybridge4_002120 CCCS(=O)(=O)C1=C(N)OC(=C(C#N)C1c2ccc(Cl)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A09 compound treatment 150440.0 -1280.0 -0.05 137360.0 -14200.0 -0.53 -0.4112 -0.7696 1227957 Maybridge4_002121 Cc1cc(N(S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)n(C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A10 compound treatment 56920.0 -94800.0 -3.68 42800.0 -109000.0 -4.08 -5.4865 -0.9987 3063685 Maybridge4_002122 CS/C(=C(/C#N)\C(=O)c1ccc(Cl)cc1)/NCC2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A11 compound treatment 162120.0 10400.0 0.4 159200.0 7670.0 0.29 0.4889 0.9862 1505422 Maybridge4_002123 O=C(Nc1cc(nn1c2ccccc2)C3CC3)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A12 compound treatment 182040.0 30300.0 1.18 146760.0 -4780.0 -0.18 0.7052 0.5926 3063686 Maybridge4_002124 CC(C)S(=O)(=O)/C(=C/Nc1ncccn1)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A13 compound treatment 192960.0 41200.0 1.6 159520.0 7990.0 0.3 1.3435 0.8252 1730851 Maybridge4_002125 Cc1ccc(cc1)C2C(=C(N)OC(=C2C#N)C3CC3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A14 compound treatment 168920.0 17200.0 0.67 289320.0 138000.0 5.17 4.1287 0.7918 3063688 Maybridge4_002126 Cn1ccnc1S(=O)(=O)/C(=C/c2ccc3OCOc3c2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A15 compound treatment 172920.0 21200.0 0.82 154640.0 3110.0 0.12 0.6642 0.7993 1337308 Maybridge4_002127 CCOC(=O)c1cnc2n(C)nc(C3CC3)c2c1N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A16 compound treatment 28440.0 -123000.0 -4.78 45720.0 -106000.0 -3.97 -6.1904 -0.9957 3063690 Maybridge4_002128 Cc1cc(nc2c(Br)c(nn12)C(C)(C)C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A17 compound treatment 164120.0 12400.0 0.48 150240.0 -1300.0 -0.05 0.3059 0.6325 1574781 Maybridge4_002129 COc1c(Cl)scc1NC(=O)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A18 compound treatment 10720.0 -141000.0 -5.47 7840.0 -144000.0 -5.39 -7.6819 -1.0 3063692 Maybridge4_002130 CSC(=C(C#N)C(=O)c1cccc(c1)C(F)(F)F)SC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A19 compound treatment 164360.0 12600.0 0.49 120080.0 -31500.0 -1.18 -0.4879 -0.3816 3178240 Maybridge4_002131 Clc1ccccc1C(=O)C(=C2SCCCS2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A20 compound treatment 179240.0 27500.0 1.07 209240.0 57700.0 2.17 2.2866 0.9469 1150123 Maybridge4_002132 CC(C)CC(NC(=O)Cc1ccsc1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A21 compound treatment 167800.0 16100.0 0.62 168920.0 17400.0 0.65 0.9027 0.9998 3063728 Maybridge4_002133 COc1cccc(c1)c2nc(N)nc(SC)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A22 compound treatment 193040.0 41300.0 1.6 166240.0 14700.0 0.55 1.524 0.8987 3178241 Maybridge4_002134 Fc1ccc(N/C=C(\C#N)/S(=O)(=O)Cc2ccco2)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A23 mock treatment 201760.0 50000.0 1.94 154880.0 3350.0 0.13 1.4618 0.7513 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 A24 mock treatment 171800.0 20100.0 0.78 170960.0 19400.0 0.73 1.0665 0.9994 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B01 compound treatment 172200.0 20500.0 0.79 166720.0 15200.0 0.57 0.965 0.9867 3178242 Maybridge4_002135 FC(F)(F)c1cc(CN/C=C(\C#N)/S(=O)(=O)Cc2ccco2)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B02 compound treatment 184080.0 32400.0 1.26 180880.0 29300.0 1.1 1.6667 0.9979 3063731 Maybridge4_002136 COC(=O)c1ccc2C(=O)/C(=C/Nc3ccc(Cl)cc3)/S(=O)(=O)N(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B03 compound treatment 162320.0 10600.0 0.41 139040.0 -12500.0 -0.47 -0.0407 -0.0652 3178243 Maybridge4_002137 CSc1sc(/C(=N\O)/C)c2CC(C)(C)C/C(=N/O)/c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B04 compound treatment 191200.0 39500.0 1.53 160960.0 9430.0 0.35 1.3334 0.8481 3063732 Maybridge4_002138 COC(=O)c1sc(SC)c(c1C)c2ccon2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B05 compound treatment 150080.0 -1640.0 -0.06 128640.0 -22900.0 -0.86 -0.6525 -0.7573 3178244 Maybridge4_002139 Clc1ccc(Sc2ccccc2CN/C(=C(\N=C\c3cccs3)/C#N)/C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B06 compound treatment 77080.0 -74600.0 -2.9 43920.0 -108000.0 -4.04 -4.9037 -0.9867 3063733 Maybridge4_002140 CN(C)/C=C/C(=O)c1ccc2OC(C)(C)CCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B07 compound treatment 148960.0 -2760.0 -0.11 115200.0 -36300.0 -1.36 -1.0399 -0.7602 1330787 Maybridge4_002141 Clc1ccc(cc1)C(=O)N(CCS(=O)(=O)c2ccc(Cl)cc2)Cc3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B08 compound treatment 179360.0 27600.0 1.07 150360.0 -1180.0 -0.04 0.7273 0.6775 3063734 Maybridge4_002142 Clc1ccc(cc1)S(=O)(=O)C(=C2SCCCCS2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B09 compound treatment 183680.0 32000.0 1.24 145080.0 -6460.0 -0.24 0.7056 0.5584 1191188 Maybridge4_002143 CSc1scc2CCc3cn(nc3-c12)C(=O)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B10 compound treatment 127600.0 -24100.0 -0.94 137480.0 -14100.0 -0.53 -1.0347 -0.9632 1483249 Maybridge4_002144 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)S(=O)(=O)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B11 compound treatment 137880.0 -13800.0 -0.54 140280.0 -11300.0 -0.42 -0.6783 -0.993 3178245 Maybridge4_002145 Cc1csc2sc(C(=O)c3ccc(Cl)cc3)c(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B12 compound treatment 168200.0 16500.0 0.64 164040.0 12500.0 0.47 0.7841 0.9884 3063735 Maybridge4_002146 FC(F)(F)c1cc(n2ncc(C(=O)NC(=S)Nc3ccccc3Cl)c2n1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B13 compound treatment 187200.0 35500.0 1.38 175920.0 24400.0 0.92 1.6207 0.9803 1629969 Maybridge4_002147 CCOC(=O)c1sc(SC)c-2c1CCc3cnc(SC)nc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B14 compound treatment 109440.0 -42300.0 -1.64 121360.0 -30200.0 -1.13 -1.9607 -0.9836 3178246 Maybridge4_002148 CC(C)CSc1nnc(CSCc2nc(cs2)c3ccc(Cl)cc3)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B15 compound treatment 157280.0 5560.0 0.22 149600.0 -1940.0 -0.07 0.1013 0.4447 1122221 Maybridge4_002149 Clc1ccc(cc1)C2CC(=CC(=S)S2)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B16 compound treatment 149920.0 -1800.0 -0.07 140560.0 -11000.0 -0.41 -0.3405 -0.8152 3063769 Maybridge4_002150 NNC(=O)c1ccc(CSc2ccc(cn2)C(F)(F)F)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B17 compound treatment 155320.0 3600.0 0.14 105760.0 -45800.0 -1.72 -1.1159 -0.6474 3178247 Maybridge4_002151 COC(=O)C1=C(CSC1)Nc2ccc(OC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B18 compound treatment 132280.0 -19400.0 -0.75 124480.0 -27100.0 -1.02 -1.2513 -0.9893 3063773 Maybridge4_002152 CC(C)(C)SC(=O)c1cccnc1SCCS(=O)(=O)c2cccc(c2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B19 compound treatment 204800.0 53100.0 2.06 162720.0 11200.0 0.42 1.7532 0.8341 3178248 Maybridge4_002153 Cc1csc2sc(/C=N/Cc3cccs3)c(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B20 compound treatment 12160.0 -140000.0 -5.41 10320.0 -141000.0 -5.3 -7.5765 -0.9999 1206852 Maybridge4_002154 CCOC(=O)c1cnc2n(C)nc(C)c2c1Sc3nnc(SC)s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B21 compound treatment 166240.0 14500.0 0.56 141040.0 -10500.0 -0.39 0.1199 0.1745 3178249 Maybridge4_002155 CS(=O)(=O)c1sc(C(=O)NC(=S)Nc2ccc(OC(F)(F)F)cc2)c3CCC=Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B22 compound treatment 144520.0 -7200.0 -0.28 120040.0 -31500.0 -1.18 -1.0333 -0.8507 3178341 Maybridge4_002156 CCOC(=O)CC1Sc2ccccc2N=C1SCC(=O)Nc3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B23 mock treatment 167240.0 15500.0 0.6 174000.0 22500.0 0.84 1.0221 0.9864 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 B24 mock treatment 162440.0 10700.0 0.42 154560.0 3030.0 0.11 0.3745 0.8683 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C01 compound treatment 196480.0 44800.0 1.74 157000.0 5470.0 0.21 1.3732 0.7852 3063777 Maybridge4_002157 CCN(CC)C(=S)NC(=S)c1ccc(C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C02 compound treatment 195720.0 44000.0 1.71 183320.0 31800.0 1.19 2.0508 0.9846 3178342 Maybridge4_002158 COC(=O)c1ccccc1S(=O)(=O)/C(=C/Nc2nc(C)cc(C)n2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C03 compound treatment 152360.0 644.0 0.02 160080.0 8550.0 0.32 0.2444 0.7599 1199477 Maybridge4_002159 CN(C1CCS(=O)(=O)C1)C(=O)COc2ccc(Oc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C04 compound treatment 122640.0 -29100.0 -1.13 62120.0 -89400.0 -3.36 -3.1707 -0.8956 3178343 Maybridge4_002160 CSc1c(C#N)c(nn1C(=O)C(C)(C)C)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C05 compound treatment 154560.0 2840.0 0.11 169880.0 18300.0 0.69 0.5649 0.8101 3063778 Maybridge4_002161 CS/C(=N/C(=N)Nc1ccc(Cl)cc1)/N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C06 compound treatment 154160.0 2440.0 0.09 107160.0 -44400.0 -1.67 -1.1106 -0.6658 3178344 Maybridge4_002162 Cc1c(csc1C(=O)Nc2ccc(F)cc2F)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C07 compound treatment 152120.0 404.0 0.02 144960.0 -6580.0 -0.25 -0.1634 -0.6609 1368486 Maybridge4_002163 OC(=O)c1ccccc1SCC(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C08 compound treatment 145960.0 -5760.0 -0.22 171360.0 19800.0 0.74 0.3682 0.474 3178345 Maybridge4_002164 CNC(=S)Nc1cscc1S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C09 compound treatment 123880.0 -27800.0 -1.08 94760.0 -56800.0 -2.13 -2.2705 -0.9504 3063810 Maybridge4_002165 Clc1cccc(NC(=S)NC(C#N)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C10 compound treatment 163640.0 11900.0 0.46 159760.0 8230.0 0.31 0.5454 0.9807 3178346 Maybridge4_002166 CN(C)/C=C/C(=O)c1cnc2cc(C)nn2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C11 compound treatment 152760.0 1040.0 0.04 149800.0 -1740.0 -0.07 -0.0174 -0.227 1175106 Maybridge4_002167 Cc1c(nnc2cc(nn12)c3ccccc3)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C12 compound treatment 160440.0 8720.0 0.34 167560.0 16000.0 0.6 0.6646 0.963 3178347 Maybridge4_002168 COC(=O)c1scc(c1n2cccc2)S(=O)(=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C13 compound treatment 176960.0 25200.0 0.98 176480.0 24900.0 0.94 1.3546 0.9997 1474680 Maybridge4_002169 NC1=C(C#N)C(C(=C(O1)C2CC2)C#N)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C14 compound treatment 146800.0 -4920.0 -0.19 152440.0 905.0 0.03 -0.1109 -0.5722 1123050 Maybridge4_002170 CC(C)S(=O)(=O)c1cscc1NC(=O)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C15 compound treatment 155600.0 3880.0 0.15 163160.0 11600.0 0.44 0.4151 0.8992 1443948 Maybridge4_002171 O=c1c2CSCc2[nH]c3cc(nn13)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C16 compound treatment 13880.0 -138000.0 -5.35 10960.0 -141000.0 -5.28 -7.5124 -1.0 3063812 Maybridge4_002172 CC(C)S(=O)(=O)c1csc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C17 compound treatment 155440.0 3720.0 0.14 163800.0 12300.0 0.46 0.4277 0.8864 1153510 Maybridge4_002173 COc1c(Cl)scc1NC(=O)N2CC(C)OC(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C18 compound treatment 172120.0 20400.0 0.79 156200.0 4670.0 0.18 0.6836 0.8431 3063813 Maybridge4_002174 CS(=O)(=O)c1scc(c1C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C19 compound treatment 102040.0 -49700.0 -1.93 90000.0 -61500.0 -2.31 -2.996 -0.996 3178348 Maybridge4_002175 CC(C)(C)c1ccc(cc1)c2n[nH]c(c2C#N)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C20 compound treatment 17080.0 -135000.0 -5.22 10320.0 -141000.0 -5.3 -7.4416 -1.0 3178349 Maybridge4_002176 Cn1nc(cc1C(F)(F)F)c2ccc(s2)C(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C21 compound treatment 163680.0 12000.0 0.46 171880.0 20300.0 0.76 0.8682 0.9715 3063814 Maybridge4_002177 COC(=O)c1sc(SC)c(C#N)c1c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C22 compound treatment 131040.0 -20700.0 -0.8 132000.0 -19500.0 -0.73 -1.0857 -0.999 3178350 Maybridge4_002178 CCN(CCS(=O)(=O)c1ccc(C)cc1)C(=O)c2ccc(s2)c3cc(nn3C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C23 mock treatment 156560.0 4840.0 0.19 156960.0 5430.0 0.2 0.2769 0.9992 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 C24 mock treatment 169920.0 18200.0 0.71 156680.0 5150.0 0.19 0.636 0.8686 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D01 compound treatment 165440.0 13700.0 0.53 151640.0 105.0 0.0 0.3793 0.7123 3063815 Maybridge4_002179 Nc1nc(ncc1S(=O)(=O)Cc2ccco2)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D02 compound treatment 161120.0 9400.0 0.36 163240.0 11700.0 0.44 0.5686 0.9957 3063818 Maybridge4_002180 CC(C)(C)S(=O)(=O)c1cnc(nc1N)c2cnccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D03 compound treatment 127960.0 -23800.0 -0.92 121440.0 -30100.0 -1.13 -1.4505 -0.9949 3178351 Maybridge4_002181 Cc1csc2sc(COC(=O)Nc3ccccc3)c(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D04 compound treatment 117840.0 -33900.0 -1.31 117240.0 -34300.0 -1.29 -1.8396 -0.9999 3178352 Maybridge4_002182 CSc1sc(C(=O)NN)c2CCCC3(SCCS3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D05 compound treatment 179320.0 27600.0 1.07 171720.0 20200.0 0.76 1.293 0.9856 3063851 Maybridge4_002183 CCOC(=O)c1sc(c2/C(=N\O)/CC(C)(C)Cc12)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D06 compound treatment 117600.0 -34100.0 -1.32 108600.0 -42900.0 -1.61 -2.0755 -0.9952 3178353 Maybridge4_002184 Cc1ccc(cc1)S(=O)(=O)CCSc2sc(C#N)c3CC(C)(C)CC(=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D07 compound treatment 143880.0 -7840.0 -0.3 173120.0 21600.0 0.81 0.3579 0.4136 1145089 Maybridge4_002185 CSc1sc(C(=O)O)c-2c1S(=O)(=O)N(C)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D08 compound treatment 104880.0 -46800.0 -1.82 88760.0 -62800.0 -2.36 -2.951 -0.9918 3178354 Maybridge4_002186 FC(F)(F)c1cccc(c1)C(=O)C(=C2SCCCCS2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D09 compound treatment 127920.0 -23800.0 -0.92 115960.0 -35600.0 -1.34 -1.597 -0.9838 3063853 Maybridge4_002187 Cn1nc(cc1C(F)(F)F)c2ccc(s2)S(=O)(=O)NCc3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D10 compound treatment 118760.0 -33000.0 -1.28 151640.0 105.0 0.0 -0.9014 -0.7049 3178355 Maybridge4_002188 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)S(=O)(=O)c4cccc(c4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D11 compound treatment 59800.0 -91900.0 -3.57 45760.0 -106000.0 -3.97 -5.329 -0.9986 3063854 Maybridge4_002189 CSc1sc(cc1S(=O)(=O)C(C)C)C(=O)Sc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D12 compound treatment 156400.0 4680.0 0.18 168520.0 17000.0 0.64 0.5793 0.8739 3178356 Maybridge4_002190 CC1(C)CCc2cc(ccc2O1)c3ccnc(S)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D13 compound treatment 63000.0 -88700.0 -3.44 57400.0 -94100.0 -3.53 -4.9323 -0.9999 3063856 Maybridge4_002191 Cc1c(Br)sc2sc(c(C)c12)c3nn(C)cc3Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D14 compound treatment 29080.0 -123000.0 -4.76 17600.0 -134000.0 -5.03 -6.9191 -0.9996 3178357 Maybridge4_002192 CSc1sc(Cl)c2CC(C)(C)C/C(=N/O)/c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D15 compound treatment 94040.0 -57700.0 -2.24 91880.0 -59700.0 -2.24 -3.1656 -1.0 3178358 Maybridge4_002193 CC(C)NC(=O)CSc1nccc(n1)c2sc3sc(Br)c(C)c3c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D16 compound treatment 169480.0 17800.0 0.69 175280.0 23700.0 0.89 1.1175 0.9919 3063857 Maybridge4_002194 Sc1nccc(n1)c2ccc3OCCc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D17 compound treatment 138400.0 -13300.0 -0.52 141840.0 -9700.0 -0.36 -0.6226 -0.9853 3063858 Maybridge4_002195 COc1ccc(CSc2nnc(CSc3cccs3)n2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D18 compound treatment 151640.0 -76.1 0.0 148240.0 -3300.0 -0.12 -0.0895 -0.7238 3178359 Maybridge4_002196 CS(=O)(=NS(=O)(=O)c1cccc2nsnc12)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D19 compound treatment 189360.0 37600.0 1.46 159520.0 7990.0 0.3 1.2447 0.8348 3178360 Maybridge4_002197 Cc1cc2ncc(c(C)n2n1)c3ccnc(SCCS(=O)(=O)c4ccccc4)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D20 compound treatment 154840.0 3120.0 0.12 143600.0 -7940.0 -0.3 -0.1249 -0.3884 3063859 Maybridge4_002198 CC(C)C1Oc2c(cccc2N(CC(=O)O)C1=S)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D21 compound treatment 137680.0 -14000.0 -0.54 146360.0 -5180.0 -0.19 -0.5224 -0.9035 3178361 Maybridge4_002199 CSc1nc(nc(c1C#N)c2ccc(OC(F)(F)F)cc2)c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D22 compound treatment 154040.0 2320.0 0.09 135600.0 -15900.0 -0.6 -0.3591 -0.5938 1139728 Maybridge4_002200 CCOC(=O)CC1Sc2ccccc2N=C1SCCS(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D23 mock treatment 145840.0 -5880.0 -0.23 152280.0 745.0 0.03 -0.1414 -0.6158 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 D24 mock treatment 159600.0 7880.0 0.31 142440.0 -9100.0 -0.34 -0.0251 -0.0547 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E01 compound treatment 165520.0 13800.0 0.54 147480.0 -4060.0 -0.15 0.2711 0.4869 1149948 Maybridge4_002201 Clc1ccc(cc1)N2CCN(CC2)C3=Cc4ccccc4C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E02 compound treatment 188440.0 36700.0 1.42 164680.0 13100.0 0.49 1.3564 0.8995 3178362 Maybridge4_002202 COC(=O)c1ccccc1S(=O)(=O)/C(=C/Nc2nc(SC)nc(n2)C3CC3)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E03 compound treatment 172160.0 20400.0 0.79 175200.0 23700.0 0.89 1.1889 0.9984 3063320 Maybridge4_002203 CSc1nc(N)n(n1)c2cc(Cl)cc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E04 compound treatment 112600.0 -39100.0 -1.52 83960.0 -67600.0 -2.54 -2.8666 -0.9699 3178363 Maybridge4_002204 CSc1n[nH]c(NC(=O)c2ccccc2Cl)c1S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E05 compound treatment 128280.0 -23400.0 -0.91 156560.0 5030.0 0.19 -0.5096 -0.5488 1032087 Maybridge4_002205 Oc1ccnc(SCc2ccc(Cl)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E06 compound treatment 156720.0 5000.0 0.19 168080.0 16500.0 0.62 0.5764 0.8859 3178364 Maybridge4_002206 CN1c2ccccc2C(=O)/C(=C\Nc3ncccn3)/S1(=O)=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E07 compound treatment 156400.0 4680.0 0.18 145200.0 -6340.0 -0.24 -0.0396 -0.1324 3063324 Maybridge4_002207 CCN(CCC#N)C(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E08 compound treatment 154520.0 2800.0 0.11 161880.0 10300.0 0.39 0.3515 0.8717 1520456 Maybridge4_002208 CCOC(=O)NS(=O)(=O)c1ccccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E09 compound treatment 97320.0 -54400.0 -2.11 89320.0 -62200.0 -2.34 -3.1435 -0.9987 1248613 Maybridge4_002209 O=c1cc([nH]c2cc(nn12)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E10 compound treatment 173160.0 21400.0 0.83 151520.0 -15.0 0.0 0.5879 0.7066 3178365 Maybridge4_002210 Cc1cccc(c1)c2n[nH]c(c2C#N)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E11 compound treatment 180800.0 29100.0 1.13 192560.0 41000.0 1.54 1.8867 0.9883 1374930 Maybridge4_002211 COc1cccc(c1)c2c(nnc3cc(nn23)c4ccccc4)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E12 compound treatment 153680.0 1960.0 0.08 163160.0 11600.0 0.44 0.3624 0.8182 1289071 Maybridge4_002212 Clc1ccc(cc1)S(=O)(=O)CCSc2ccccc2NC(=O)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E13 compound treatment 155360.0 3640.0 0.14 176360.0 24800.0 0.93 0.7588 0.8052 1391332 Maybridge4_002213 COc1ccc(cc1)C2C(=C(N)OC(=C2C#N)C3CC3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E14 compound treatment 140000.0 -11700.0 -0.45 151400.0 -135.0 -0.01 -0.325 -0.7149 3063326 Maybridge4_002214 Cc1nccc(n1)c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E15 compound treatment 151760.0 43.9 0.0 179920.0 28400.0 1.07 0.7545 0.7082 3178456 Maybridge4_002215 Cn1nc(cc1N)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E16 compound treatment 153240.0 1520.0 0.06 143640.0 -7900.0 -0.3 -0.1677 -0.5551 1540260 Maybridge4_002216 CC(C)S(=O)(=O)c1csc(NC(=O)N2CCCCC2)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E17 compound treatment 152760.0 1040.0 0.04 165600.0 14100.0 0.53 0.4019 0.7591 1698879 Maybridge4_002217 Nc1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E18 compound treatment 124440.0 -27300.0 -1.06 108120.0 -43400.0 -1.63 -1.9005 -0.9782 1598720 Maybridge4_002218 Clc1ccc(cc1)c2csc(S(=O)C3CCCCC3)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E19 compound treatment 153920.0 2200.0 0.09 174400.0 22900.0 0.86 0.6673 0.7737 1438402 Maybridge4_002219 O=C(c1ccccc1)c2cnc3ccccn3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E20 compound treatment 141120.0 -10600.0 -0.41 141040.0 -10500.0 -0.39 -0.5692 -0.9998 3178457 Maybridge4_002220 CN(C)c1scc(c1C#N)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E21 compound treatment 140560.0 -11200.0 -0.43 134520.0 -17000.0 -0.64 -0.7576 -0.9821 3178458 Maybridge4_002221 Cc1ccc(cc1)S(=O)(=O)/C(=C/Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E22 compound treatment 164000.0 12300.0 0.48 154040.0 2510.0 0.09 0.4035 0.8306 1367919 Maybridge4_002222 O=S(=O)(Cc1ccco1)Cc2nc(cs2)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E23 mock treatment 149760.0 -1960.0 -0.08 166360.0 14800.0 0.56 0.3398 0.605 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 E24 mock treatment 163520.0 11800.0 0.46 159600.0 8070.0 0.3 0.5379 0.9798 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F01 compound treatment 166080.0 14400.0 0.56 145080.0 -6460.0 -0.24 0.2228 0.3666 3063357 Maybridge4_002223 CNC(=O)c1cc(C#N)c(SC)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F02 compound treatment 151160.0 -556.0 -0.02 170560.0 19000.0 0.71 0.4896 0.6854 3178459 Maybridge4_002224 CSc1scc2CCc3cnc(SCC(=O)c4ccc(Cl)cc4)nc3-c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F03 compound treatment 172960.0 21200.0 0.82 163840.0 12300.0 0.46 0.9094 0.9625 3063358 Maybridge4_002225 Cc1csc2sc(C(=O)Oc3ccc(Cl)cc3)c(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F04 compound treatment 172320.0 20600.0 0.8 170480.0 18900.0 0.71 1.0681 0.9983 3178460 Maybridge4_002226 Nc1nc(ncc1S(=O)(=O)c2ccc(cn2)C(F)(F)F)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F05 compound treatment 134040.0 -17700.0 -0.69 137080.0 -14500.0 -0.54 -0.8686 -0.9933 3063359 Maybridge4_002227 CSc1sc(cc1c2nc(C)cs2)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F06 compound treatment 128520.0 -23200.0 -0.9 119920.0 -31600.0 -1.19 -1.4754 -0.9907 3178461 Maybridge4_002228 CC(C)S(=O)(=O)c1cscc1NC(=O)c2ccc(s2)c3cc(nn3C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F07 compound treatment 158160.0 6440.0 0.25 154880.0 3350.0 0.13 0.2656 0.9492 1693988 Maybridge4_002229 CS(=O)(=O)c1sc(C(=O)Nc2ccccc2Cl)c3CCC=Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F08 compound treatment 155400.0 3680.0 0.14 203080.0 51500.0 1.93 1.469 0.7573 3178462 Maybridge4_002230 CSc1sc(c2ccon2)c(c1C#N)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F09 compound treatment 14880.0 -137000.0 -5.31 13040.0 -138000.0 -5.2 -7.4297 -0.9999 3178463 Maybridge4_002231 CC1(C)CC(=O)C=C(SCC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F10 compound treatment 146080.0 -5640.0 -0.22 154360.0 2830.0 0.11 -0.0797 -0.3278 3063360 Maybridge4_002232 FC(F)(F)c1ccc(nc1)S(=O)(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F11 compound treatment 164480.0 12800.0 0.5 159360.0 7830.0 0.29 0.5579 0.9689 3178464 Maybridge4_002233 CS(=O)(=NS(=O)(=O)c1ccc(s1)c2ccccn2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F12 compound treatment 15280.0 -136000.0 -5.29 15160.0 -136000.0 -5.12 -7.3625 -0.9999 3063362 Maybridge4_002234 C/S(=N\C(=O)Nc1ccc(Cl)cc1)/c2sc(Cl)c3CCCC(=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F13 compound treatment 154240.0 2520.0 0.1 167600.0 16100.0 0.6 0.4956 0.8113 3178465 Maybridge4_002235 CS(=O)(=NC(=S)NC(=O)Oc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F14 compound treatment 149960.0 -1760.0 -0.07 164600.0 13100.0 0.49 0.2986 0.6031 3063392 Maybridge4_002236 FC(F)(F)c1cnc(N2CCS(=NC(=O)c3ccccc3)CC2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F15 compound treatment 108920.0 -42800.0 -1.66 117160.0 -34400.0 -1.29 -2.0864 -0.9922 3178466 Maybridge4_002237 Cc1c(Br)sc2sc(c(C)c12)c3ccnc(SCC(=O)NCC=C)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F16 compound treatment 135520.0 -16200.0 -0.63 121520.0 -30000.0 -1.13 -1.2409 -0.962 1201268 Maybridge4_002238 C(Sc1nccc(n1)c2ccc3OCCc3c2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F17 compound treatment 132040.0 -19700.0 -0.76 114920.0 -36600.0 -1.37 -1.5116 -0.9615 1378146 Maybridge4_002239 CS(=O)(=O)c1sc(NC(=O)Nc2ccc(Cl)cc2)c3CCC=Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F18 compound treatment 169880.0 18200.0 0.7 147800.0 -3740.0 -0.14 0.3992 0.5556 1406686 Maybridge4_002240 Cc1nn(Cc2cccc(c2)C(=O)NC(=O)Nc3ccc(Cl)cc3)c(C)c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F19 compound treatment 142960.0 -8760.0 -0.34 153720.0 2190.0 0.08 -0.1822 -0.5214 1721379 Maybridge4_002241 O=S(=O)(N1CCCCC1)c2ccc(s2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F20 compound treatment 163920.0 12200.0 0.47 165800.0 14300.0 0.54 0.7134 0.9981 3063394 Maybridge4_002242 CN(C)/C=C\1/C(=O)c2sccc2N(C)S1(=O)=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F21 compound treatment 167880.0 16200.0 0.63 178680.0 27100.0 1.02 1.1639 0.9728 3178467 Maybridge4_002243 CSc1sc(c(C)c1c2ccnc(S)n2)c3nc(C)cs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F22 compound treatment 156560.0 4840.0 0.19 145080.0 -6460.0 -0.24 -0.0384 -0.1253 1422989 Maybridge4_002244 Clc1ccc(OC(=O)c2csc(n2)C3COc4ccccc4O3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F23 mock treatment 162320.0 10600.0 0.41 149360.0 -2180.0 -0.08 0.2332 0.556 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 F24 mock treatment 161240.0 9520.0 0.37 153240.0 1710.0 0.06 0.3065 0.8174 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G01 compound treatment 87240.0 -64500.0 -2.5 105800.0 -45700.0 -1.72 -2.9827 -0.9831 1651892 Maybridge4_002245 CCCCC1(Cc2ccccc2)C(=O)Nc3ccccc3C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G02 compound treatment 169760.0 18000.0 0.7 164600.0 13100.0 0.49 0.8418 0.9848 3178468 Maybridge4_002246 CSc1nc(N/C=C(\C#N)/S(=O)(=O)c2ccccc2Cl)nc(n1)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G03 compound treatment 125800.0 -25900.0 -1.01 126800.0 -24700.0 -0.93 -1.3675 -0.9992 3063398 Maybridge4_002247 CC(=N)NC(=S)Nc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G04 compound treatment 156720.0 5000.0 0.19 143720.0 -7820.0 -0.29 -0.0701 -0.1993 3178469 Maybridge4_002248 CSc1n[nH]c(NC(=O)Nc2ccccc2)c1S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G05 compound treatment 113880.0 -37800.0 -1.47 111280.0 -40300.0 -1.51 -2.1064 -0.9999 3063400 Maybridge4_002249 CN(C)C(=O)Oc1ccnc(SCc2c(F)cccc2Cl)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G06 compound treatment 159920.0 8200.0 0.32 162680.0 11100.0 0.42 0.5209 0.9909 3178470 Maybridge4_002250 COc1ccc(cc1)c2n[nH]c(SC)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G07 compound treatment 133040.0 -18700.0 -0.72 144560.0 -6980.0 -0.26 -0.6975 -0.9053 3063401 Maybridge4_002251 Cc1ccc(COc2ccc(I)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G08 compound treatment 170160.0 18400.0 0.72 164560.0 13000.0 0.49 0.8517 0.9827 3178471 Maybridge4_002252 CSc1sc(C(=O)Nc2cccc(Cl)c2)c(c1C#N)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G09 compound treatment 151880.0 164.0 0.01 146800.0 -4740.0 -0.18 -0.1212 -0.6814 1687124 Maybridge4_002253 CCN(CCS(=O)(=O)c1ccccc1)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G10 compound treatment 166040.0 14300.0 0.56 158640.0 7110.0 0.27 0.5815 0.9434 3178472 Maybridge4_002254 COC(=O)c1scc(c1N)S(=O)(=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G11 compound treatment 150400.0 -1320.0 -0.05 146040.0 -5500.0 -0.21 -0.1819 -0.8563 1226475 Maybridge4_002255 NC(=O)c1nnc2cc(nn2c1N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G12 compound treatment 144720.0 -7000.0 -0.27 162360.0 10800.0 0.41 0.0953 0.1951 1452741 Maybridge4_002256 Clc1ccc(cc1)S(=O)(=O)CCSc2ccccc2NC(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G13 compound treatment 114520.0 -37200.0 -1.44 123120.0 -28400.0 -1.07 -1.7746 -0.9889 3063431 Maybridge4_002257 Fc1cccc(Cl)c1CN/C(=C(\N=C\c2cccs2)/C#N)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G14 compound treatment 142200.0 -9520.0 -0.37 165200.0 13700.0 0.51 0.1016 0.1607 3178473 Maybridge4_002258 Clc1cccc(Cl)c1CSc2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G15 compound treatment 128320.0 -23400.0 -0.91 154360.0 2830.0 0.11 -0.5669 -0.6203 3178474 Maybridge4_002259 COc1ccc(/C=C(\C#N)/S(=O)(=O)c2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G16 compound treatment 16520.0 -135000.0 -5.25 15880.0 -136000.0 -5.09 -7.3094 -0.9999 1133071 Maybridge4_002260 CNC(=O)Nc1ccccc1NC2=C(CSC2)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G17 compound treatment 144360.0 -7360.0 -0.29 143840.0 -7700.0 -0.29 -0.406 -1.0 3178475 Maybridge4_002261 CC1CN(CC(C)O1)/C=C(\C#N)/S(=O)(=O)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G18 compound treatment 127560.0 -24200.0 -0.94 133040.0 -18500.0 -0.69 -1.1536 -0.9891 3063432 Maybridge4_002262 CS(=O)(=NS(=O)(=O)c1ccccc1C(F)(F)F)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G19 compound treatment 156200.0 4480.0 0.17 152040.0 505.0 0.02 0.1364 0.7795 1259331 Maybridge4_002263 COCc1cc(O)nc2n(C)nc(c3cccs3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G20 compound treatment 147960.0 -3760.0 -0.15 156440.0 4910.0 0.18 0.0271 0.1155 3063433 Maybridge4_002264 CS/C(=C(/C#N)\S(=O)(=O)C(C)C)/N1CCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G21 compound treatment 144000.0 -7720.0 -0.3 180800.0 29300.0 1.1 0.565 0.4963 3178476 Maybridge4_002265 CSc1c(C#N)c(nn1CC(=O)NN)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G22 compound treatment 142200.0 -9520.0 -0.37 142880.0 -8660.0 -0.32 -0.4908 -0.998 3063434 Maybridge4_002266 Cc1onc(c1C(=O)N=S(=O)(C)C)c2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G23 mock treatment 136800.0 -14900.0 -0.58 154160.0 2630.0 0.1 -0.3396 -0.5784 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 G24 mock treatment 147200.0 -4520.0 -0.18 138720.0 -12800.0 -0.48 -0.464 -0.9064 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H01 compound treatment 137800.0 -13900.0 -0.54 139760.0 -11800.0 -0.44 -0.6943 -0.9951 3178477 Maybridge4_002267 CCOC(=O)c1sc(SCc2ccccc2)c(c1n3cccc3)S(=O)(=O)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H02 compound treatment 100800.0 -50900.0 -1.98 108600.0 -42900.0 -1.61 -2.5364 -0.9949 1259984 Maybridge4_002268 CSc1scc2CCc3cnc(SCC(=O)C(C)(C)C)nc3-c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H03 compound treatment 147600.0 -4120.0 -0.16 167280.0 15700.0 0.59 0.3049 0.4981 3063436 Maybridge4_002269 CSc1sc(cc1S(=O)(=O)C(C)C)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H04 compound treatment 159840.0 8120.0 0.32 162120.0 10600.0 0.4 0.5038 0.9934 3178558 Maybridge4_002270 COC(=O)c1sc(SCCOC(=O)c2ccccc2Cl)c3C(=O)CC(C)(C)Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H05 compound treatment 174480.0 22800.0 0.88 200960.0 49400.0 1.86 1.9362 0.9424 3063438 Maybridge4_002271 CSc1sc(C#N)c(C)c1c2ccn(n2)C(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H06 compound treatment 152720.0 1000.0 0.04 151680.0 145.0 0.01 0.0314 0.7982 3178559 Maybridge4_002272 CSc1sc(C(=O)/C=C/N(C)C)c(c1C#N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H07 compound treatment 13600.0 -138000.0 -5.36 13080.0 -138000.0 -5.2 -7.4638 -0.9999 1222048 Maybridge4_002273 CS(=O)c1sc(C(=O)OCc2ccccc2)c3CC(C)(C)CC(=O)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H08 compound treatment 121320.0 -30400.0 -1.18 122960.0 -28600.0 -1.07 -1.5923 -0.9989 3178560 Maybridge4_002274 CSc1sc(c2cc[nH]n2)c(c1C#N)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H09 compound treatment 125080.0 -26600.0 -1.03 128040.0 -23500.0 -0.88 -1.3543 -0.9969 3178561 Maybridge4_002275 CC1(C)CC(=O)C=C(SCc2c(Cl)cccc2Cl)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H10 compound treatment 151520.0 -196.0 -0.01 165000.0 13500.0 0.51 0.352 0.6964 1307156 Maybridge4_002276 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)C(=O)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H11 compound treatment 150280.0 -1440.0 -0.06 134440.0 -17100.0 -0.64 -0.4931 -0.7656 3063440 Maybridge4_002277 CSc1nnc(c2ccc(s2)S(=O)(=O)n3nc(C)cc3C)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H12 compound treatment 146960.0 -4760.0 -0.18 154760.0 3230.0 0.12 -0.0449 -0.2035 3178562 Maybridge4_002278 CCSc1nccc(n1)c2ccc3OC(C)(C)CCc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H13 compound treatment 157280.0 5560.0 0.22 181360.0 29800.0 1.12 0.9442 0.8282 3063442 Maybridge4_002279 Cc1csc2sc(c(C)c12)c3ccnc(SCc4ccccc4)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H14 compound treatment 165160.0 13400.0 0.52 165160.0 13600.0 0.51 0.7304 1.0 3178563 Maybridge4_002280 CCOC(=O)c1sc(/S(=N/C(=O)Nc2ccccc2Cl)/C)c3C=CCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H15 compound treatment 133160.0 -18600.0 -0.72 145840.0 -5700.0 -0.21 -0.6602 -0.8791 1505800 Maybridge4_002281 COC(=O)C(CC(C)C)NS(=O)(=O)c1ccc(s1)c2nnc(SC)n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H16 compound treatment 156840.0 5120.0 0.2 150160.0 -1380.0 -0.05 0.1041 0.5068 3178564 Maybridge4_002282 FC(F)(F)c1ccc(nc1)S(=O)(=O)CCSc2ncccc2C(=O)NCc3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H17 compound treatment 139600.0 -12100.0 -0.47 103560.0 -48000.0 -1.8 -1.6056 -0.8628 3178565 Maybridge4_002283 Clc1ccc(cc1)C2CC(=O)C=C(SCC(=O)c3ccccc3)S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H18 compound treatment 141120.0 -10600.0 -0.41 167640.0 16100.0 0.6 0.1367 0.187 3063443 Maybridge4_002284 C/C(=N\O)/c1ccc2OCCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H19 compound treatment 165680.0 14000.0 0.54 162360.0 10800.0 0.41 0.6704 0.9899 3063445 Maybridge4_002285 CC1(C)CC(=O)c2c(SCC(=O)NN)sc(C#N)c2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H20 compound treatment 162720.0 11000.0 0.43 143280.0 -8260.0 -0.31 0.0828 0.157 1254429 Maybridge4_002286 Cc1nn(C)c2ncc(C(=O)N)c(Oc3cccnc3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H21 compound treatment 128560.0 -23200.0 -0.9 127680.0 -23900.0 -0.9 -1.2684 -1.0 3063446 Maybridge4_002287 CCOC(=O)c1sc(SC)c2c1CCCC32SCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H22 compound treatment 152520.0 804.0 0.03 148440.0 -3100.0 -0.12 -0.0601 -0.4995 1921420 Maybridge4_002288 OC(=O)/C=C/1\OC(=O)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H23 mock treatment 146880.0 -4840.0 -0.19 146480.0 -5060.0 -0.19 -0.2668 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 H24 mock treatment 151960.0 244.0 0.01 149440.0 -2100.0 -0.08 -0.0489 -0.6176 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I01 compound treatment 157720.0 6000.0 0.23 165080.0 13500.0 0.51 0.5242 0.9374 3178566 Maybridge4_002289 Cc1ccc(cc1)C(=O)OC[C@H]2O[C@@H](C[C@@H]2OC(=O)c3ccc(C)cc3)c4nnc5ncccn45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I02 compound treatment 73960.0 -77800.0 -3.02 87280.0 -64300.0 -2.41 -3.8386 -0.9938 3178567 Maybridge4_002290 FC(F)(F)c1cc(N/C=C(\C#N)/S(=O)(=O)Cc2ccc(Cl)cc2)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I03 compound treatment 157760.0 6040.0 0.23 152640.0 1110.0 0.04 0.1951 0.8194 3063447 Maybridge4_002291 CCOC(=O)c1c(C)noc1c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I04 compound treatment 164640.0 12900.0 0.5 151160.0 -375.0 -0.01 0.3446 0.687 3064096 Maybridge4_002292 CSc1sc(NC(=O)N2CCOCC2)c(c1C#N)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I05 compound treatment 145600.0 -6120.0 -0.24 145960.0 -5580.0 -0.21 -0.3158 -0.998 3064097 Maybridge4_002293 CCOC(=O)/C=C/1\NC(=O)CS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I06 compound treatment 44440.0 -107000.0 -4.16 50080.0 -101000.0 -3.81 -5.6357 -0.999 3064098 Maybridge4_002294 CSc1[nH]nc(c1C#N)c2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I07 compound treatment 152840.0 1120.0 0.04 155920.0 4390.0 0.16 0.1472 0.8646 3064099 Maybridge4_002295 Fc1ccc(NC(=S)N(CCC#N)CC2CCCO2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I08 compound treatment 134080.0 -17600.0 -0.68 148440.0 -3100.0 -0.12 -0.566 -0.8155 3064100 Maybridge4_002296 CSc1sc(C(=O)O)c(C)c1S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I09 compound treatment 148800.0 -2920.0 -0.11 142920.0 -8620.0 -0.32 -0.3086 -0.901 1242964 Maybridge4_002297 Cc1nn(c(NC(=O)c2ccccc2)c1C#N)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I10 compound treatment 140240.0 -11500.0 -0.45 146080.0 -5460.0 -0.2 -0.4596 -0.9378 3064101 Maybridge4_002298 CC(C)(C)S(=O)(=O)/C(=C/Nc1ccccn1)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I11 compound treatment 145280.0 -6440.0 -0.25 157800.0 6270.0 0.24 -0.0103 -0.0301 1003716 Maybridge4_002299 Cc1ccc(cc1)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I12 compound treatment 153360.0 1640.0 0.06 167680.0 16100.0 0.61 0.4736 0.7772 3064102 Maybridge4_002300 COC(=O)c1scc(c1/N=C/N(C)C)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I13 compound treatment 48120.0 -104000.0 -4.02 48680.0 -103000.0 -3.86 -5.5719 -0.9998 3178568 Maybridge4_002301 COc1cccc(c1)C(=O)/C=c/2\[nH]c(=O)\c(=C/c3cccs3)\s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I14 compound treatment 130360.0 -21400.0 -0.83 147280.0 -4260.0 -0.16 -0.6988 -0.8281 1621333 Maybridge4_002302 Cc1nccc(n1)c2cccc(NC(=O)Nc3ccccc3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I15 compound treatment 21880.0 -130000.0 -5.04 17680.0 -134000.0 -5.02 -7.1145 -1.0 1156135 Maybridge4_002303 CC(C)(C)c1ccc(cc1)c2n[nH]c(NS(=O)(=O)c3ccccc3)c2Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I16 compound treatment 161880.0 10200.0 0.39 199600.0 48100.0 1.8 1.5545 0.8418 3064103 Maybridge4_002304 COC(=O)c1sc(SC)c(C#N)c1c2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I17 compound treatment 127360.0 -24400.0 -0.95 138520.0 -13000.0 -0.49 -1.0136 -0.9528 1665125 Maybridge4_002305 O=C(Nc1ccccc1)Nc2ccc(cc2)C3SCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I18 compound treatment 149040.0 -2680.0 -0.1 138000.0 -13500.0 -0.51 -0.4326 -0.8344 3064104 Maybridge4_002306 O=S(=O)(C(=C1SCCCS1)C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I19 compound treatment 151200.0 -516.0 -0.02 165760.0 14200.0 0.53 0.3634 0.6801 3178569 Maybridge4_002307 CSc1nc2cc(C)nn2c(c1C#N)c3ccc(cc3)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I20 compound treatment 138800.0 -12900.0 -0.5 151000.0 -535.0 -0.02 -0.3686 -0.7348 3178570 Maybridge4_002308 Cc1ccc(cc1)S(=O)(=NC(=O)NC(=O)c2c(Cl)cccc2Cl)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I21 compound treatment 153960.0 2240.0 0.09 169280.0 17700.0 0.67 0.5325 0.7928 3064105 Maybridge4_002309 CSc1nc(C)nc(N/C=C(\C#N)/S(=O)(=O)c2ccc(C)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I22 compound treatment 155360.0 3640.0 0.14 143960.0 -7580.0 -0.28 -0.1011 -0.3183 1118314 Maybridge4_002310 NNC(=O)c1csc(CS(=O)(=O)Cc2ccco2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I23 mock treatment 142320.0 -9400.0 -0.36 152760.0 1230.0 0.05 -0.2253 -0.6131 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 I24 mock treatment 155440.0 3720.0 0.14 143880.0 -7660.0 -0.29 -0.101 -0.314 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J01 compound treatment 140000.0 -11700.0 -0.45 177000.0 25500.0 0.96 0.3544 0.3348 3064106 Maybridge4_002311 CSc1sc(c2n[nH]cc2Br)c3CC(C)(C)CC(=O)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J02 compound treatment 131520.0 -20200.0 -0.78 144800.0 -6740.0 -0.25 -0.7328 -0.89 3178571 Maybridge4_002312 CSc1scc2CCc3cnc(SCC(=O)NCC=C)nc3-c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J03 compound treatment 177200.0 25500.0 0.99 167680.0 16100.0 0.61 1.1276 0.9724 3064107 Maybridge4_002313 CSc1sc(C#N)c2CC(CC(=O)c12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J04 compound treatment 152440.0 724.0 0.03 156440.0 4910.0 0.18 0.15 0.8057 3178572 Maybridge4_002314 NC(=S)c1cnn2c(cc(nc12)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J05 compound treatment 148560.0 -3160.0 -0.12 149360.0 -2180.0 -0.08 -0.1443 -0.9806 3064108 Maybridge4_002315 COC(=O)c1sccc1N/C=C(\C#N)/S(=O)(=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J06 compound treatment 153480.0 1760.0 0.07 160840.0 9310.0 0.35 0.2953 0.8299 3178573 Maybridge4_002316 CCOC(=O)c1sc(SC)c-2c1CCc3conc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J07 compound treatment 135560.0 -16200.0 -0.63 181800.0 30300.0 1.14 0.3599 0.2774 3178574 Maybridge4_002317 Cc1nn(Cc2nnc(o2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c(C)c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J08 compound treatment 149040.0 -2680.0 -0.1 157760.0 6230.0 0.23 0.0918 0.359 3064109 Maybridge4_002318 CCCS(=O)(=O)/C(=C/c1sccc1Oc2ccccc2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J09 compound treatment 123920.0 -27800.0 -1.08 141040.0 -10500.0 -0.39 -1.0411 -0.9068 3178575 Maybridge4_002319 Cc1ccc(cc1)S(=O)(=O)CCSC2=CC(=O)CC(C)(C)S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J10 compound treatment 175440.0 23700.0 0.92 166800.0 15300.0 0.57 1.056 0.974 3064110 Maybridge4_002320 Clc1ccc(cc1)c2ccnc(SCCS(=O)(=O)c3ccc(Cl)cc3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J11 compound treatment 90800.0 -60900.0 -2.36 118160.0 -33400.0 -1.25 -2.557 -0.9559 3178576 Maybridge4_002321 CSc1sc(C(=O)Sc2ccccc2)c-3c1S(=O)(=O)N(C)c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J12 compound treatment 159880.0 8160.0 0.32 174040.0 22500.0 0.84 0.8212 0.9104 1454764 Maybridge4_002322 CCOC(=O)C1=C(Nc2ccc(OC(=O)C)cc2)C(=O)N(C1)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J13 compound treatment 144120.0 -7600.0 -0.29 169960.0 18400.0 0.69 0.2806 0.3732 3178577 Maybridge4_002323 Cc1csc2sc(c(C)c12)c3ccnc(SCC(=O)c4ccccc4)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J14 compound treatment 142520.0 -9200.0 -0.36 154840.0 3310.0 0.12 -0.1646 -0.4357 3178578 Maybridge4_002324 CCOC(=O)c1sc(/S(=N/S(=O)(=O)c2cccc(Cl)c2)/C)c3C=CCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J15 compound treatment 148640.0 -3080.0 -0.12 175680.0 24100.0 0.91 0.5564 0.6087 3064111 Maybridge4_002325 COc1cccc(NC(=S)N=S(=O)(C)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J16 compound treatment 137280.0 -14400.0 -0.56 164400.0 12900.0 0.48 -0.0546 -0.0739 3178579 Maybridge4_002326 CCCCc1ccc(NC(=O)N=S2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J17 compound treatment 156960.0 5240.0 0.2 174600.0 23100.0 0.87 0.756 0.8501 3064112 Maybridge4_002327 Cc1nn(Cc2nnc(SCc3c(Cl)cccc3Cl)o2)c(C)c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J18 compound treatment 147440.0 -4280.0 -0.17 159240.0 7710.0 0.29 0.0872 0.2614 3178580 Maybridge4_002328 C/S(=N/C(=O)Nc1ccc(Cl)cc1)/c2ccc(OC(=O)c3ccc(Cl)cc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J19 compound treatment 139920.0 -11800.0 -0.46 142880.0 -8660.0 -0.32 -0.5533 -0.9859 3064113 Maybridge4_002329 CS(=O)(=NS(=O)(=O)c1cc(cs1)S(=O)(=O)c2ccccc2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J20 compound treatment 175480.0 23800.0 0.92 159920.0 8390.0 0.31 0.8745 0.8976 1183286 Maybridge4_002330 CN1c2ccsc2-c3nc(SCc4ccc(Cl)cc4)ncc3S1(=O)=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J21 compound treatment 136560.0 -15200.0 -0.59 148000.0 -3540.0 -0.13 -0.5096 -0.8454 3064114 Maybridge4_002331 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)CCSc2ccc(cn2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J22 compound treatment 132200.0 -19500.0 -0.76 132760.0 -18800.0 -0.7 -1.0337 -0.9994 3178581 Maybridge4_002332 O=C(CCN1CCC(=N1)c2cccs2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J23 mock treatment 143600.0 -8120.0 -0.31 158840.0 7310.0 0.27 -0.0288 -0.069 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 J24 mock treatment 154320.0 2600.0 0.1 152760.0 1230.0 0.05 0.1039 0.9365 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K01 compound treatment 137360.0 -14400.0 -0.56 160520.0 8990.0 0.34 -0.1554 -0.2387 3064115 Maybridge4_002333 C/C(=C\C#N)/Nc1c(C)n(C)n(c2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K02 compound treatment 149000.0 -2720.0 -0.11 136920.0 -14600.0 -0.55 -0.4624 -0.8278 3178657 Maybridge4_002334 CSc1sc(C(=O)O)c(c1C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K03 compound treatment 158680.0 6960.0 0.27 157280.0 5750.0 0.22 0.3435 0.9937 1629094 Maybridge4_002335 NC(=S)NN1C2CSC1CS2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K04 compound treatment 163800.0 12100.0 0.47 161440.0 9910.0 0.37 0.5944 0.9934 3178658 Maybridge4_002336 CSc1c(C#N)c(nn1C(=O)c2cccs2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K05 compound treatment 138000.0 -13700.0 -0.53 136600.0 -14900.0 -0.56 -0.7727 -0.9997 3178659 Maybridge4_002337 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCCN3C2c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K06 compound treatment 140840.0 -10900.0 -0.42 136960.0 -14600.0 -0.55 -0.6852 -0.9918 3064116 Maybridge4_002338 CSc1nc(/N=C/N(C)C)n2nc(cc2n1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K07 compound treatment 130040.0 -21700.0 -0.84 138040.0 -13500.0 -0.51 -0.9528 -0.9705 3178660 Maybridge4_002339 CN(CCC#N)C(=S)Nc1ccc(F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K08 compound treatment 139800.0 -11900.0 -0.46 160440.0 8910.0 0.33 -0.0906 -0.1588 3064117 Maybridge4_002340 COC(=O)c1scc(C#N)c1/N=C/N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K09 compound treatment 139440.0 -12300.0 -0.48 142280.0 -9260.0 -0.35 -0.5824 -0.988 1197958 Maybridge4_002341 CCN(CCS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K10 compound treatment 149400.0 -2320.0 -0.09 173520.0 22000.0 0.83 0.5199 0.6264 1372972 Maybridge4_002342 COc1ncccc1C(=O)Nc2ccc(F)cc2F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K11 compound treatment 149160.0 -2560.0 -0.1 147840.0 -3700.0 -0.14 -0.1682 -0.9865 3178661 Maybridge4_002343 CC(=O)Nc1c(Br)c(nn1c2ccccc2)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K12 compound treatment 142880.0 -8840.0 -0.34 149200.0 -2340.0 -0.09 -0.3044 -0.8602 3064118 Maybridge4_002344 O=S(=O)(/C(=C/c1ccc(\C=C(/C#N)\S(=O)(=O)c2ccccc2)cc1)/C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K13 compound treatment 146160.0 -5560.0 -0.22 157000.0 5470.0 0.21 -0.0074 -0.0249 3178662 Maybridge4_002345 Oc1c2CN(C3CCCCC3)C(=O)c2nc4cc(nn14)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K14 compound treatment 140120.0 -11600.0 -0.45 147800.0 -3740.0 -0.14 -0.4173 -0.8854 1503351 Maybridge4_002346 CNC(=O)Nc1cccc(c1)c2ccnc(C)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K15 compound treatment 164080.0 12400.0 0.48 170640.0 19100.0 0.72 0.8462 0.9809 3178663 Maybridge4_002347 Clc1ccc(cc1)S(=O)(=O)/C(=C/c2ccccc2Cl)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K16 compound treatment 149600.0 -2120.0 -0.08 147880.0 -3660.0 -0.14 -0.1551 -0.9699 1326810 Maybridge4_002348 CC(C)S(=O)(=O)c1cnc(nc1N)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K17 compound treatment 138880.0 -12800.0 -0.5 148600.0 -2940.0 -0.11 -0.4301 -0.8431 3064119 Maybridge4_002349 CNC(=O)Nc1ccc(cc1)C2SCCS2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K18 compound treatment 123760.0 -28000.0 -1.08 142320.0 -9220.0 -0.35 -1.0116 -0.8885 1218060 Maybridge4_002350 CCOC(=O)c1cnc2c(csc2c1Sc3ccc(Cl)cc3)S(=O)(=O)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K19 compound treatment 149680.0 -2040.0 -0.08 180520.0 29000.0 1.09 0.7134 0.654 3064120 Maybridge4_002351 CSc1nc2cc(C)nn2c(c3ccco3)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K20 compound treatment 140360.0 -11400.0 -0.44 129240.0 -22300.0 -0.84 -0.9033 -0.9551 1209169 Maybridge4_002352 CS(=O)N(C(=O)c1scc(c1C)S(=O)(=O)c2ccc(Cl)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K21 compound treatment 149000.0 -2720.0 -0.11 154480.0 2950.0 0.11 0.0036 0.0238 1134325 Maybridge4_002353 COCc1cc(OC(=O)N(C)C)nc2n(C)nc(c3cccs3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K22 compound treatment 142600.0 -9120.0 -0.35 152640.0 1110.0 0.04 -0.2208 -0.62 1310626 Maybridge4_002354 CCOC(=O)CSc1sc(C(=O)OCC)c-2c1S(=O)(=O)N(C)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K23 mock treatment 157800.0 6080.0 0.24 144600.0 -6940.0 -0.26 -0.0171 -0.0488 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 K24 mock treatment 140920.0 -10800.0 -0.42 158000.0 6470.0 0.24 -0.1246 -0.2574 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L01 compound treatment 107920.0 -43800.0 -1.7 120720.0 -30800.0 -1.16 -2.0194 -0.9824 3064121 Maybridge4_002355 CSc1sc(c2ccn(n2)C(=O)Nc3ccccc3)c4CC(C)(C)CC(=O)c14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L02 compound treatment 160080.0 8360.0 0.32 149960.0 -1580.0 -0.06 0.1877 0.5689 3178664 Maybridge4_002356 CS(=O)(=N/C=C(\C#N)/S(=O)(=O)c1ccc(cn1)C(F)(F)F)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L03 compound treatment 145240.0 -6480.0 -0.25 152280.0 745.0 0.03 -0.1579 -0.6246 3064122 Maybridge4_002357 CSc1sc(C#N)c(C)c1C(=O)/C=C/N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L04 compound treatment 152280.0 564.0 0.02 159760.0 8230.0 0.31 0.2338 0.7553 3178665 Maybridge4_002358 CCOC(=O)c1sc(SCCS(=O)(=O)c2ccc(Cl)cc2)c3C(=O)CCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L05 compound treatment 137160.0 -14600.0 -0.56 136240.0 -15300.0 -0.57 -0.8053 -1.0 1438715 Maybridge4_002359 Cc1c(C=C)c(sc1C(=O)Oc2ccccc2)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L06 compound treatment 156040.0 4320.0 0.17 183000.0 31500.0 1.18 0.9537 0.7995 3178666 Maybridge4_002360 CC1(C)CC(=O)c2c(SCCOC(=O)c3ccccc3Cl)sc(C#N)c2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L07 compound treatment 125000.0 -26700.0 -1.04 30200.0 -121000.0 -4.55 -3.9531 -0.8464 3064123 Maybridge4_002361 Cc1nn(Cc2nc(cs2)C(C)(C)C)c(C)c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L08 compound treatment 137640.0 -14100.0 -0.55 159280.0 7750.0 0.29 -0.1806 -0.292 1009905 Maybridge4_002362 CC(=O)Nc1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L09 compound treatment 123320.0 -28400.0 -1.1 128440.0 -23100.0 -0.87 -1.392 -0.993 3178667 Maybridge4_002363 CSc1sc(c2CCCC(=O)c12)c3ccnc(SCC(=O)c4ccc(Cl)cc4)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L10 compound treatment 137040.0 -14700.0 -0.57 153200.0 1670.0 0.06 -0.3585 -0.6258 3064124 Maybridge4_002364 O=S1(=O)CC=C(C1)Sc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L11 compound treatment 138360.0 -13400.0 -0.52 150400.0 -1140.0 -0.04 -0.3966 -0.7627 3178668 Maybridge4_002365 Cc1cc(C)n(CCS(=O)(=O)c2ccc(Cl)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L12 compound treatment 14360.0 -137000.0 -5.33 15760.0 -136000.0 -5.1 -7.3718 -0.9997 3064125 Maybridge4_002366 Clc1ccc(cc1)C(=O)Nc2cc(cs2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L13 compound treatment 121440.0 -30300.0 -1.17 120000.0 -31500.0 -1.18 -1.6676 -1.0 3178669 Maybridge4_002367 Cc1csc2sc(c(C)c12)c3ccnc(SCC(=O)NCc4ccccc4)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L14 compound treatment 138320.0 -13400.0 -0.52 156440.0 4910.0 0.18 -0.2374 -0.4305 1344584 Maybridge4_002368 COC(=O)c1c(C)n2CSCc2c1C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L15 compound treatment 158720.0 7000.0 0.27 155320.0 3790.0 0.14 0.2926 0.9542 3178670 Maybridge4_002369 CN(C)/C=C/C(=O)c1ccsc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L16 compound treatment 95720.0 -56000.0 -2.17 141080.0 -10500.0 -0.39 -1.8138 -0.8215 1542795 Maybridge4_002370 CCCCc1ccc(NC(=O)N=S2CCN(CC2)C(=O)c3ccc(Cl)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L17 compound treatment 13600.0 -138000.0 -5.36 30880.0 -121000.0 -4.53 -6.9914 -0.9965 1463535 Maybridge4_002371 CN1c2sc(C)c(C)c2C(=C(C(=O)Nc3ccc(Cl)cc3)S1(=O)=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L18 compound treatment 125280.0 -26400.0 -1.03 142960.0 -8580.0 -0.32 -0.9529 -0.8864 1537505 Maybridge4_002372 Cc1occc1C(=O)C(=C(NCc2cccnc2)NCc3cccnc3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L19 compound treatment 93640.0 -58100.0 -2.25 110760.0 -40800.0 -1.53 -2.6755 -0.9822 3064207 Maybridge4_002373 CS(=O)(=O)c1cc2cc(Cl)ccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L20 compound treatment 51760.0 -100000.0 -3.88 54280.0 -97300.0 -3.65 -5.3234 -0.9995 3064208 Maybridge4_002374 FC(F)(F)c1ccc(SC(=O)c2csc(n2)C3COc4ccccc4O3)nc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L21 compound treatment 134560.0 -17200.0 -0.67 145720.0 -5820.0 -0.22 -0.625 -0.8922 3064209 Maybridge4_002375 CN(C)/C=N/C(=O)c1sc(c2C=CCCc12)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L22 compound treatment 157960.0 6240.0 0.24 147160.0 -4380.0 -0.16 0.0552 0.1886 1320320 Maybridge4_002376 O=C(C1Cc2ccccc2C1)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L23 mock treatment 138360.0 -13400.0 -0.52 142920.0 -8620.0 -0.32 -0.5951 -0.9742 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 L24 mock treatment 149360.0 -2360.0 -0.09 151520.0 -15.0 0.0 -0.065 -0.7114 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M01 compound treatment 142440.0 -9280.0 -0.36 148440.0 -3100.0 -0.12 -0.3366 -0.8901 3064210 Maybridge4_002377 OC(=O)c1ccc2ccccc2c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M02 compound treatment 75600.0 -76100.0 -2.95 130400.0 -21100.0 -0.79 -2.6492 -0.8663 3064211 Maybridge4_002378 Clc1ccc(cc1)S(=O)(=O)/C(=C/Nc2cccc(Cl)c2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M03 compound treatment 146960.0 -4760.0 -0.18 151280.0 -255.0 -0.01 -0.1373 -0.7428 3178671 Maybridge4_002379 COC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M04 compound treatment 168680.0 17000.0 0.66 160880.0 9350.0 0.35 0.7134 0.9566 3178672 Maybridge4_002380 CCOC(=O)/C(=C\Nc1ccc(F)c(Cl)c1)/S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M05 compound treatment 10320.0 -141000.0 -5.49 12480.0 -139000.0 -5.22 -7.5697 -0.9997 3064212 Maybridge4_002381 Clc1ccc(/C=C/C(=O)Nc2cccc(Cl)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M06 compound treatment 136760.0 -15000.0 -0.58 145720.0 -5820.0 -0.22 -0.5647 -0.9108 3064213 Maybridge4_002382 NNC(=O)CS(=O)(=O)c1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M07 compound treatment 106120.0 -45600.0 -1.77 137640.0 -13900.0 -0.52 -1.6197 -0.8782 3178673 Maybridge4_002383 Cc1cc(C)cc(NC(=S)Nc2cc(C)cc(C)c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M08 compound treatment 85800.0 -65900.0 -2.56 143000.0 -8540.0 -0.32 -2.035 -0.7895 3178674 Maybridge4_002384 Clc1ccc(SCC(=O)Nc2cscc2S(=O)(=O)c3ccc(Cl)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M09 compound treatment 137440.0 -14300.0 -0.55 131400.0 -20100.0 -0.76 -0.926 -0.9883 1165743 Maybridge4_002385 CCN(CCS(=O)(=O)c1ccc(Cl)cc1)S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M10 compound treatment 136880.0 -14800.0 -0.58 159600.0 8070.0 0.3 -0.193 -0.2968 3178675 Maybridge4_002386 Clc1ccccc1NC(=S)Nc2cscc2S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M11 compound treatment 128560.0 -23200.0 -0.9 147640.0 -3900.0 -0.15 -0.7387 -0.8115 1302916 Maybridge4_002387 CC(C)(C)n1nc(cc1NC(=O)Nc2ccccc2)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M12 compound treatment 138760.0 -13000.0 -0.5 147160.0 -4380.0 -0.16 -0.4716 -0.8917 3178676 Maybridge4_002388 COC(=O)c1sc(SC)c(c1C)c2ccn(n2)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M13 compound treatment 137040.0 -14700.0 -0.57 147400.0 -4140.0 -0.16 -0.5124 -0.8682 3064215 Maybridge4_002389 COc1c(Cl)scc1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M14 compound treatment 140040.0 -11700.0 -0.45 171560.0 20000.0 0.75 0.2111 0.2406 3178677 Maybridge4_002390 CC(C)S(=O)(=O)c1csc(C(=O)NN)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M15 compound treatment 11360.0 -140000.0 -5.45 14240.0 -137000.0 -5.15 -7.4945 -0.9996 1619049 Maybridge4_002391 CC(C)(C)c1ccc(cc1)c2[nH]nc(NC(=O)c3ccccc3Cl)c2Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M16 compound treatment 132640.0 -19100.0 -0.74 150080.0 -1460.0 -0.05 -0.562 -0.7572 3178678 Maybridge4_002392 CSc1sc(C(=O)O)c(I)c1S(=O)(=O)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M17 compound treatment 10440.0 -141000.0 -5.48 35560.0 -116000.0 -4.35 -6.9539 -0.9935 3178679 Maybridge4_002393 CC(C)(C)c1ccc(cc1)C(=O)C(=C2SCCCS2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M18 compound treatment 138240.0 -13500.0 -0.52 146880.0 -4660.0 -0.17 -0.4933 -0.8947 3064216 Maybridge4_002394 CS(=O)(=NC(=O)Nc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M19 compound treatment 132160.0 -19600.0 -0.76 160680.0 9150.0 0.34 -0.2938 -0.3528 3178680 Maybridge4_002395 CSc1nc2cc(C)nn2c(c1C#N)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M20 compound treatment 131280.0 -20400.0 -0.79 135280.0 -16300.0 -0.61 -0.9921 -0.9916 1447748 Maybridge4_002396 Clc1ccccc1c2csc(CS(=O)(=O)c3cccs3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M21 compound treatment 102440.0 -49300.0 -1.91 106760.0 -44800.0 -1.68 -2.5402 -0.9979 3178681 Maybridge4_002397 CSc1nc(N)n2nc(cc2n1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M22 compound treatment 54880.0 -96800.0 -3.76 103720.0 -47800.0 -1.79 -3.9257 -0.9428 3178753 Maybridge4_002398 CN(C)/C=C/C(=O)c1sc(SCc2ccc(Cl)cc2)c3C(=O)CC(C)(C)Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M23 mock treatment 151000.0 -716.0 -0.03 159640.0 8110.0 0.3 0.1955 0.6399 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 M24 mock treatment 146880.0 -4840.0 -0.19 142320.0 -9220.0 -0.35 -0.3772 -0.9587 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N01 compound treatment 96040.0 -55700.0 -2.16 139080.0 -12500.0 -0.47 -1.8581 -0.8407 3064217 Maybridge4_002399 CCOC(=O)c1sc2sc(C(=O)OCC)c(c3ccc(Cl)cc3)c2c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N02 compound treatment 138480.0 -13200.0 -0.51 146560.0 -4980.0 -0.19 -0.4952 -0.9062 3064244 Maybridge4_002400 CCOC(=O)NS(=O)(=O)c1ccc(s1)c2cc(n(C)n2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N03 compound treatment 130480.0 -21200.0 -0.82 144600.0 -6940.0 -0.26 -0.7667 -0.8873 3064245 Maybridge4_002401 CSc1scc2CC(C)(C)CC(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N04 compound treatment 125040.0 -26700.0 -1.04 131120.0 -20400.0 -0.77 -1.2737 -0.989 3064246 Maybridge4_002402 CC1(C)CCc2cc(ccc2O1)C3SCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N05 compound treatment 129640.0 -22100.0 -0.86 150600.0 -935.0 -0.04 -0.6305 -0.7355 3064248 Maybridge4_002403 Cc1nn(CC(=S)N)c(C)c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N06 compound treatment 147280.0 -4440.0 -0.17 152200.0 665.0 0.02 -0.1041 -0.5983 1138975 Maybridge4_002404 CC(C)S(=O)(=O)c1cscc1N2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N07 compound treatment 85000.0 -66700.0 -2.59 136280.0 -15300.0 -0.57 -2.2353 -0.8431 3064249 Maybridge4_002405 Fc1cccc(NC(=S)N(CCS(=O)(=O)c2ccc(Cl)cc2)Cc3cccs3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N08 compound treatment 115920.0 -35800.0 -1.39 145200.0 -6340.0 -0.24 -1.1502 -0.8163 3064250 Maybridge4_002406 Clc1ccc(C(=O)C2C(=O)CCC(C2=O)c3ccccc3)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N09 compound treatment 120040.0 -31700.0 -1.23 124480.0 -27100.0 -1.02 -1.5871 -0.9955 3064251 Maybridge4_002407 CSc1sc(c2CC(C)(C)CC(=O)c12)c3ccnc(SCC(=O)C(C)(C)C)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N10 compound treatment 131200.0 -20500.0 -0.8 149120.0 -2420.0 -0.09 -0.627 -0.7826 1318871 Maybridge4_002408 Cn1ccnc1SCCS(=O)(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N11 compound treatment 130240.0 -21500.0 -0.83 147920.0 -3620.0 -0.14 -0.6852 -0.8116 1250473 Maybridge4_002409 CCOC(=O)c1sc(SCc2ccccc2)c3c1-c4sccc4N(C)S3(=O)=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N12 compound treatment 136400.0 -15300.0 -0.59 150200.0 -1340.0 -0.05 -0.4556 -0.764 3064253 Maybridge4_002410 FC(F)(F)c1cc(cc(c1)S(=O)(=O)/N=S\2/CCC3(C2)OCCO3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N13 compound treatment 159040.0 7320.0 0.28 181760.0 30200.0 1.13 1.0031 0.8577 1662782 Maybridge4_002411 CSc1sc(c2nc(cs2)C(C)(C)C)c3CCCC(=O)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N14 compound treatment 146320.0 -5400.0 -0.21 149560.0 -1980.0 -0.07 -0.2005 -0.9026 1607185 Maybridge4_002412 Clc1ccc(cc1)C(=O)N=S2CCN(CC2)C(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N15 compound treatment 138800.0 -12900.0 -0.5 156480.0 4950.0 0.19 -0.2231 -0.4175 3178754 Maybridge4_002413 COC(=O)C1=C(CSC1)Nc2ccc(OC(=O)c3cccc(c3)C(F)(F)F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N16 compound treatment 117040.0 -34700.0 -1.35 142160.0 -9380.0 -0.35 -1.2002 -0.863 1495489 Maybridge4_002414 Clc1ccc(OC(=O)c2cccnc2SCCS(=O)(=O)c3ccccc3)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N17 compound treatment 99640.0 -52100.0 -2.02 113480.0 -38100.0 -1.43 -2.4387 -0.9856 3178755 Maybridge4_002415 CSc1sc(C(=O)NN)c2CCC=Cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N18 compound treatment 138920.0 -12800.0 -0.5 151240.0 -295.0 -0.01 -0.3589 -0.7227 3178756 Maybridge4_002416 CS(=O)(=NS(=O)(=O)c1cccs1)c2ccc(OC(=O)c3ccc(Cl)cc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N19 compound treatment 131960.0 -19800.0 -0.77 142000.0 -9540.0 -0.36 -0.7951 -0.9398 3064254 Maybridge4_002417 CS(=O)(=O)/C(=C/Nc1cnccn1)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N20 compound treatment 134280.0 -17400.0 -0.68 144760.0 -6780.0 -0.25 -0.6582 -0.9107 1627111 Maybridge4_002418 O=C(SCc1cccs1)c2csc(n2)C3COc4ccccc4O3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N21 compound treatment 112880.0 -38800.0 -1.51 133040.0 -18500.0 -0.69 -1.5563 -0.9381 3064255 Maybridge4_002419 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)CCN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N22 compound treatment 86600.0 -65100.0 -2.53 87840.0 -63700.0 -2.39 -3.4769 -0.9996 3178757 Maybridge4_002420 Clc1ccc(cc1)c2cc(NC(=O)C3Cc4ccccc4C3)[nH]n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N23 mock treatment 131800.0 -19900.0 -0.77 140440.0 -11100.0 -0.42 -0.8409 -0.9579 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 N24 mock treatment 135320.0 -16400.0 -0.64 142040.0 -9500.0 -0.36 -0.7018 -0.9625 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O01 compound treatment 84240.0 -67500.0 -2.62 129200.0 -22300.0 -0.84 -2.444 -0.8891 1259648 Maybridge4_002421 COc1ccc(NC(=O)C(C(=O)Nc2ccc(OC)cc2)C3(CC4CC5CC(C4)C3)C5)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O02 compound treatment 108560.0 -43200.0 -1.67 136640.0 -14900.0 -0.56 -1.5793 -0.8946 3064256 Maybridge4_002422 FC(F)(F)c1cc(N/C=C(\C#N)/S(=O)(=O)c2ccccn2)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O03 compound treatment 107720.0 -44000.0 -1.71 137400.0 -14100.0 -0.53 -1.5822 -0.8851 1743228 Maybridge4_002423 Cc1ccc(Nc2cc(O)nn2C)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O04 compound treatment 156200.0 4480.0 0.17 172320.0 20800.0 0.78 0.6746 0.8441 3064257 Maybridge4_002424 CCn1c(S)nc2ccccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O05 compound treatment 11840.0 -140000.0 -5.43 42120.0 -109000.0 -4.11 -6.7414 -0.9905 3178758 Maybridge4_002425 Cc1c(C)c(C)c(CSc2ccccc2N)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O06 compound treatment 63920.0 -87800.0 -3.41 130200.0 -21300.0 -0.8 -2.975 -0.8501 3064258 Maybridge4_002426 CS/C(=C(\C#N)/C(=O)C1CC1)/N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O07 compound treatment 157480.0 5760.0 0.22 161400.0 9870.0 0.37 0.4199 0.9709 1286597 Maybridge4_002427 O=S(=O)(CCN1CCSCC1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O08 compound treatment 111040.0 -40700.0 -1.58 161080.0 9550.0 0.36 -0.8627 -0.533 3064259 Maybridge4_002428 Clc1ccccc1C(=O)Nc2cscc2S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O09 compound treatment 130800.0 -20900.0 -0.81 158320.0 6790.0 0.25 -0.3938 -0.463 3178759 Maybridge4_002429 O=S(=O)(CCSc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O10 compound treatment 141480.0 -10200.0 -0.4 150520.0 -1020.0 -0.04 -0.3078 -0.7714 1558086 Maybridge4_002430 COC(=O)C1=C(CSC1)Nc2ccc(F)cc2F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O11 compound treatment 100280.0 -51400.0 -2.0 157200.0 5670.0 0.21 -1.2609 -0.6282 3064260 Maybridge4_002431 Cc1cc(C)n2nc(cc2n1)c3ccc(cc3)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O12 compound treatment 126920.0 -24800.0 -0.96 134560.0 -17000.0 -0.64 -1.1308 -0.98 3178760 Maybridge4_002432 CC(C)S(=O)(=O)c1csc(C(=O)OCC(=O)c2ccc(Cl)cc2)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O13 compound treatment 132600.0 -19100.0 -0.74 140200.0 -11300.0 -0.43 -0.8253 -0.9652 3064262 Maybridge4_002433 Clc1ccc(cc1)S(=O)(=O)/C(=C/N2CCCCC2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O14 compound treatment 162760.0 11000.0 0.43 163640.0 12100.0 0.45 0.6243 0.9996 3178761 Maybridge4_002434 Fc1ccc(NC(=O)c2cccnc2Sc3cccs3)c(F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O15 compound treatment 144240.0 -7480.0 -0.29 192800.0 41300.0 1.55 0.89 0.5648 3064263 Maybridge4_002435 Nc1nc(Sc2ccc(Cl)cc2)c(C#N)c(c1C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O16 compound treatment 76200.0 -75500.0 -2.93 136760.0 -14800.0 -0.55 -2.464 -0.8263 3178762 Maybridge4_002436 CSc1scc(c1C#N)c2cc(Cl)cc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O17 compound treatment 121680.0 -30000.0 -1.17 165160.0 13600.0 0.51 -0.4625 -0.3634 3064280 Maybridge4_002437 O=C(C(=C1SCCCS1)C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O18 compound treatment 117000.0 -34700.0 -1.35 154040.0 2510.0 0.09 -0.886 -0.6562 3064281 Maybridge4_002438 CN(/N=C(\C#N)/C(=O)C1CC1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O19 compound treatment 160920.0 9200.0 0.36 160080.0 8550.0 0.32 0.4793 0.9986 1358615 Maybridge4_002439 COCc1cc(OC(=O)N(C)C)nc2n(C)nc(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O20 compound treatment 91720.0 -60000.0 -2.33 117240.0 -34300.0 -1.29 -2.5562 -0.961 1379175 Maybridge4_002440 Cn1ccc(n1)c2cccc(NC(=O)Nc3ccccc3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O21 compound treatment 122000.0 -29700.0 -1.15 168880.0 17300.0 0.65 -0.355 -0.2681 3064282 Maybridge4_002441 CSc1c(C#N)c(nn1CNC(=O)Nc2ccccc2C(F)(F)F)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O22 compound treatment 127960.0 -23800.0 -0.92 135960.0 -15600.0 -0.58 -1.0651 -0.9758 3064283 Maybridge4_002442 CCOC(=O)c1sc(SCc2c(Cl)cccc2Cl)c(c1N)S(=O)(=O)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O23 mock treatment 170200.0 18500.0 0.72 150760.0 -775.0 -0.03 0.4866 0.6779 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 O24 mock treatment 151920.0 204.0 0.01 156960.0 5430.0 0.2 0.1496 0.734 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P01 compound treatment 9640.0 -142000.0 -5.51 11000.0 -141000.0 -5.27 -7.6276 -0.9998 3064285 Maybridge4_002443 Nc1c(C#N)sc2sc(C#N)c(c3ccco3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P02 compound treatment 144920.0 -6800.0 -0.26 167960.0 16400.0 0.62 0.2494 0.372 3064286 Maybridge4_002444 CC(C)(C)c1ncc(c(N)n1)S(=O)(=O)c2ccc(cn2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P03 compound treatment 139680.0 -12000.0 -0.47 149320.0 -2220.0 -0.08 -0.389 -0.8201 3178763 Maybridge4_002445 CCOC(=O)c1sc(SC)c2C(=O)CC(Cc12)c3ccc(OC)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P04 compound treatment 140040.0 -11700.0 -0.45 154320.0 2790.0 0.1 -0.2464 -0.53 3178764 Maybridge4_002446 CCOC(=O)c1sc(Sc2ccc(cn2)C(F)(F)F)c3C(=O)CC(C)(C)Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P05 compound treatment 140200.0 -11500.0 -0.45 151480.0 -55.0 0.0 -0.3174 -0.7104 1299033 Maybridge4_002447 CS(=O)(=O)c1sc(C(=O)O)c2CCC=Cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P06 compound treatment 138600.0 -13100.0 -0.51 171680.0 20100.0 0.76 0.1748 0.1918 1436320 Maybridge4_002448 Cc1cc(C)n(n1)c2ncc(c(N)n2)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P07 compound treatment 85120.0 -66600.0 -2.58 155720.0 4190.0 0.16 -1.7161 -0.6629 3178765 Maybridge4_002449 CSc1scc2CCc3cn(nc3-c12)C(=O)c4cccc(c4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P08 compound treatment 139120.0 -12600.0 -0.49 151400.0 -135.0 -0.01 -0.3492 -0.7144 3178766 Maybridge4_002450 CS(=O)(=NC(=O)NC(=O)c1ccc(Cl)cc1)c2ccc(cn2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P09 compound treatment 116680.0 -35000.0 -1.36 156240.0 4710.0 0.18 -0.8364 -0.6101 3064288 Maybridge4_002451 O=S(=O)(N1CCCCC1)c2ccc(s2)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P10 compound treatment 137560.0 -14200.0 -0.55 161480.0 9950.0 0.37 -0.1245 -0.1874 3064289 Maybridge4_002452 COC(=O)c1cnc(S)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P11 compound treatment 42960.0 -109000.0 -4.22 79760.0 -71800.0 -2.69 -4.8887 -0.9765 3178767 Maybridge4_002453 FC(F)(F)c1cc(NC(=S)NC(=O)Oc2ccccc2)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P12 compound treatment 145600.0 -6120.0 -0.24 152600.0 1070.0 0.04 -0.1395 -0.5798 3064290 Maybridge4_002454 Cc1ccc(SCC(=O)c2ccc(CC(=O)O)s2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P13 compound treatment 206240.0 54500.0 2.12 150800.0 -735.0 -0.03 1.4764 0.6978 3178768 Maybridge4_002455 CS(=O)(=NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P14 compound treatment 114160.0 -37600.0 -1.46 150200.0 -1340.0 -0.05 -1.0658 -0.731 3064291 Maybridge4_002456 CN(C)/C=C/C(=O)c1ccc2OCCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P15 compound treatment 136440.0 -15300.0 -0.59 226320.0 74800.0 2.81 1.5656 0.5458 3178769 Maybridge4_002457 Cc1cc2ncc(c(C)n2n1)c3ccnc(SCc4c(Cl)cccc4Cl)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P16 compound treatment 180080.0 28400.0 1.1 160920.0 9390.0 0.35 1.0273 0.889 3064292 Maybridge4_002458 CS(=O)(=O)CCSc1ncccc1C(=O)NCc2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P17 compound treatment 98880.0 -52800.0 -2.05 160000.0 8470.0 0.32 -1.225 -0.5905 1476633 Maybridge4_002459 CCOC(=O)c1sc(N2CCCCC2)c3C(=O)CC(C)(C)Cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P18 compound treatment 137120.0 -14600.0 -0.57 145920.0 -5620.0 -0.21 -0.5495 -0.9093 3064293 Maybridge4_002460 OC(=O)C1Cc2ccccc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P19 compound treatment 137680.0 -14000.0 -0.54 156320.0 4790.0 0.18 -0.2581 -0.4501 3178770 Maybridge4_002461 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/Nc2cnccn2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P20 compound treatment 79480.0 -72200.0 -2.8 105480.0 -46100.0 -1.73 -3.2041 -0.973 1356891 Maybridge4_002462 CCOC(=O)CC1Sc2ccccc2N=C1SCC(=O)Nc3ccc(Cl)cc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P21 compound treatment 139200.0 -12500.0 -0.49 148760.0 -2780.0 -0.1 -0.417 -0.8397 3064294 Maybridge4_002463 Clc1ccc(Sc2ccc(s2)c3ccccn3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P22 compound treatment 112320.0 -39400.0 -1.53 123240.0 -28300.0 -1.06 -1.8318 -0.9842 1623679 Maybridge4_002464 Cc1ccc(NC(=O)c2ccc3OCCc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P23 mock treatment 145680.0 -6040.0 -0.23 134600.0 -16900.0 -0.64 -0.615 -0.908 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2055 P24 mock treatment 135200.0 -16500.0 -0.64 136960.0 -14600.0 -0.55 -0.8399 -0.9969 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A01 compound treatment 188000.0 36600.0 1.42 177520.0 22700.0 0.85 1.6078 0.9701 3179279 Maybridge4_002817 CCOC(=S)Nc1ccc(I)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A02 compound treatment 65840.0 -85500.0 -3.32 108800.0 -46000.0 -1.73 -3.5675 -0.9537 3179280 Maybridge4_002818 Cn1c(/C=C/C=C/N2CCCC2)nc3ccccc3c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A03 compound treatment 155600.0 4240.0 0.16 179840.0 25000.0 0.94 0.7804 0.8184 3063974 Maybridge4_002819 CCCn1c(n[nH]c1=O)c2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A04 compound treatment 14120.0 -137000.0 -5.33 28520.0 -126000.0 -4.74 -7.1171 -0.9983 3179380 Maybridge4_002820 CCOC(=O)c1cnc(S/C=C/C(=O)c2ccc(Cl)cc2)nc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A05 compound treatment 142280.0 -9080.0 -0.35 171400.0 16600.0 0.62 0.191 0.267 1487054 Maybridge4_002821 Cc1ccccc1S(=O)c2ccccc2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A06 compound treatment 100040.0 -51300.0 -1.99 126320.0 -28500.0 -1.07 -2.1643 -0.9575 3064003 Maybridge4_002822 N(/C=N/c1ccc2ccccc2c1)c3ccc4ccccc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A07 compound treatment 151960.0 598.0 0.02 165920.0 11100.0 0.42 0.3111 0.7453 1198685 Maybridge4_002823 CC(C)CC(NC(=O)Nc1cccc2ccccc12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A08 compound treatment 155240.0 3880.0 0.15 150920.0 -3890.0 -0.15 0.003 0.0145 3064005 Maybridge4_002824 FC(F)(F)c1ncncc1c2nnnn2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A09 compound treatment 96000.0 -55400.0 -2.15 135440.0 -19400.0 -0.73 -2.0331 -0.8965 3064006 Maybridge4_002825 CN(C)/C=C(\C(=S)c1ccccc1)/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A10 compound treatment 8120.0 -143000.0 -5.56 10360.0 -144000.0 -5.42 -7.7636 -0.9999 3064007 Maybridge4_002826 Clc1ccc(O/C=C/C(=O)c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A11 compound treatment 130960.0 -20400.0 -0.79 156720.0 1910.0 0.07 -0.5092 -0.6406 1652788 Maybridge4_002827 CN1C(=O)C(Cc2ccccc2)(Cc3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A12 compound treatment 141600.0 -9760.0 -0.38 157000.0 2190.0 0.08 -0.2098 -0.5414 3064008 Maybridge4_002828 O=c1[nH]c2ccccc2c(=O)n1CCNCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A13 compound treatment 140520.0 -10800.0 -0.42 141600.0 -13200.0 -0.5 -0.6482 -0.9966 3064009 Maybridge4_002829 C/C(=N\O)/C(=O)Nc1cccc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A14 compound treatment 9080.0 -142000.0 -5.52 9800.0 -145000.0 -5.44 -7.7522 -1.0 3179381 Maybridge4_002830 Clc1ccc(/C=C(\C#N)/c2c[nH]c3ccccc23)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A15 compound treatment 148160.0 -3200.0 -0.12 158280.0 3470.0 0.13 0.0041 0.0229 3179382 Maybridge4_002831 O=C(/C=C\1/Nc2[nH]c(=S)[nH]c(=O)c2NC1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A16 compound treatment 101000.0 -50400.0 -1.95 92040.0 -62800.0 -2.36 -3.0477 -0.9957 3064010 Maybridge4_002832 FC(F)(F)c1ccc(/C=C(\C#N)/c2cn(C(=O)C3CCC3)c4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A17 compound treatment 165000.0 13600.0 0.53 173800.0 19000.0 0.71 0.878 0.9893 1477955 Maybridge4_002833 Cc1c(O)c(C(=O)c2nn[nH]n2)c(=O)n(c3ccccc3)c1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A18 compound treatment 154760.0 3400.0 0.13 151920.0 -2890.0 -0.11 0.0164 0.0961 1152993 Maybridge4_002834 COc1ccc(CC(=O)NN2C(=O)CSCC2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A19 compound treatment 8920.0 -142000.0 -5.53 12920.0 -142000.0 -5.33 -7.6738 -0.9998 3179383 Maybridge4_002835 O=C(C/C(=C\1/CCc2ccccc2C1=O)/c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A20 compound treatment 9200.0 -142000.0 -5.52 24280.0 -131000.0 -4.9 -7.3646 -0.9983 3179384 Maybridge4_002836 CC1CC(CC(C)(C)C1)NC(=S)NCc2csc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A21 compound treatment 6800.0 -145000.0 -5.61 8040.0 -147000.0 -5.51 -7.8614 -1.0 1438428 Maybridge4_002837 CC12CCC3C(CC=C4CC(O)CCC34CO)C2CCC1OC(=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A22 compound treatment 112680.0 -38700.0 -1.5 171480.0 16700.0 0.63 -0.619 -0.3807 3179385 Maybridge4_002838 CC(=O)Nc1ccc(cc1)C2=N/C(=C/c3cn(C(=O)C)c4ccccc34)/C(=O)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A23 mock treatment 152040.0 678.0 0.03 158000.0 3190.0 0.12 0.1031 0.8424 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 A24 mock treatment 159400.0 8040.0 0.31 193120.0 38300.0 1.44 1.2371 0.8409 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B01 compound treatment 190560.0 39200.0 1.52 200240.0 45400.0 1.7 2.281 0.9984 1595249 Maybridge4_002839 COc1ccc(cc1)C2C(C(=O)O)c3ccccc3C(=O)N2Cc4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B02 compound treatment 169600.0 18200.0 0.71 146320.0 -8490.0 -0.32 0.2749 0.3543 3064011 Maybridge4_002840 FC(F)(F)c1nnc(Nc2cccnc2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B03 compound treatment 150160.0 -1200.0 -0.05 177040.0 22200.0 0.83 0.5569 0.6665 1011958 Maybridge4_002841 CC(=O)Nc1ccc(Cc2ccc(NC(=O)C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B04 compound treatment 101600.0 -49800.0 -1.93 57720.0 -97100.0 -3.64 -3.942 -0.9559 3179386 Maybridge4_002842 O=C1N(C2CCCCC2)/C(=N/C3CCCCC3)/SC41CC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B05 compound treatment 144840.0 -6520.0 -0.25 162960.0 8150.0 0.31 0.0372 0.0938 3064012 Maybridge4_002843 CS/C(=N\C#N)/N=c\1/nc(SC)n(C)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B06 compound treatment 9400.0 -142000.0 -5.51 13360.0 -141000.0 -5.31 -7.6489 -0.9998 3179387 Maybridge4_002844 Cc1cc(S)nc(n1)c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B07 compound treatment 142000.0 -9360.0 -0.36 183320.0 28500.0 1.07 0.4997 0.4422 3064013 Maybridge4_002845 Cc1csc(Nc2c(C)cccc2C)[n+]1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B08 compound treatment 160480.0 9120.0 0.35 188880.0 34100.0 1.28 1.1542 0.8701 3179388 Maybridge4_002846 Cc1nc(nc(NCCNc2cc(ccn2)C(F)(F)F)c1Cl)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B09 compound treatment 132760.0 -18600.0 -0.72 164520.0 9710.0 0.36 -0.2528 -0.3127 3064014 Maybridge4_002847 Clc1ccc(/C=C(\C#N)/c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B10 compound treatment 103600.0 -47800.0 -1.85 136360.0 -18500.0 -0.69 -1.8002 -0.9099 1673007 Maybridge4_002848 COc1ccc(CCNC(=O)C(Sc2ccc(Cl)cc2)c3ccccc3)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B11 compound treatment 123760.0 -27600.0 -1.07 131320.0 -23500.0 -0.88 -1.3808 -0.9953 1278976 Maybridge4_002849 CSc1nc2ccccc2c(=O)n1CCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B12 compound treatment 69640.0 -81700.0 -3.17 104960.0 -49900.0 -1.87 -3.5652 -0.9683 3179389 Maybridge4_002850 CCOC(=O)/C(=N\O)/C1=CSC2=NNC(C)(C)N12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B13 compound treatment 147440.0 -3920.0 -0.15 169360.0 14500.0 0.55 0.2784 0.4913 1697626 Maybridge4_002851 Oc1ccccc1C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B14 compound treatment 146640.0 -4720.0 -0.18 146040.0 -8770.0 -0.33 -0.3624 -0.9617 1029066 Maybridge4_002852 OC(Cc1cccnc1)(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B15 compound treatment 130440.0 -20900.0 -0.81 146240.0 -8570.0 -0.32 -0.8016 -0.9179 3179390 Maybridge4_002853 Cn/1c(cs\c1=N/C(=S)NCCc2ccccc2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B16 compound treatment 143880.0 -7480.0 -0.29 162240.0 7430.0 0.28 -0.0082 -0.0204 1414388 Maybridge4_002854 Cc1ccc2onc(OC(=O)NC(C)(C)C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B17 compound treatment 143560.0 -7800.0 -0.3 177120.0 22300.0 0.84 0.3779 0.4245 3064015 Maybridge4_002855 CS/C(=N\c1ccc(Cl)cc1)/N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B18 compound treatment 11160.0 -140000.0 -5.44 26800.0 -128000.0 -4.8 -7.2439 -0.9981 1450668 Maybridge4_002856 CNC(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B19 compound treatment 122320.0 -29000.0 -1.13 151520.0 -3290.0 -0.12 -0.8842 -0.78 1567287 Maybridge4_002857 COc1cc(CSc2nnnn2c3ccc(C)cc3C)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B20 compound treatment 149320.0 -2040.0 -0.08 150800.0 -4010.0 -0.15 -0.1626 -0.955 1505699 Maybridge4_002858 COC(=O)c1c(NC(=O)N(C)C)onc1c2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B21 compound treatment 147720.0 -3640.0 -0.14 141960.0 -12900.0 -0.48 -0.4411 -0.8774 1506761 Maybridge4_002859 NCCSC(=S)NC1CCCCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B22 compound treatment 148400.0 -2960.0 -0.11 152560.0 -2250.0 -0.08 -0.1411 -0.9886 3064016 Maybridge4_002860 CN(C)/C=N/C1NC(=O)N(C)C(=N1)C2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B23 mock treatment 160520.0 9160.0 0.36 165480.0 10700.0 0.4 0.5343 0.9982 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 B24 mock treatment 147680.0 -3680.0 -0.14 165840.0 11000.0 0.41 0.1916 0.4376 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C01 compound treatment 160480.0 9120.0 0.35 164160.0 9350.0 0.35 0.4982 1.0 1030385 Maybridge4_002861 S=C(NC1CCCCC1)C(=S)NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C02 compound treatment 158440.0 7080.0 0.27 154320.0 -494.0 -0.02 0.1811 0.6579 3064017 Maybridge4_002862 Clc1ccc(cc1)C(=O)c2[n+]([N-]C#N)ccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C03 compound treatment 168800.0 17400.0 0.68 164040.0 9230.0 0.35 0.7233 0.9516 3179391 Maybridge4_002863 CCCn1c(n[nH]c1=O)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C04 compound treatment 12760.0 -139000.0 -5.38 10480.0 -144000.0 -5.42 -7.6332 -1.0 3064018 Maybridge4_002864 O=C(/C=C/Sc1ccccn1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C05 compound treatment 150360.0 -1000.0 -0.04 180800.0 26000.0 0.98 0.6621 0.6784 3179392 Maybridge4_002865 CCNS(=O)(=O)c1ccc(Cl)cc1I 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C06 compound treatment 144560.0 -6800.0 -0.26 169040.0 14200.0 0.53 0.1909 0.3205 3064054 Maybridge4_002866 CC1C(O/C(=N\S(=O)(=O)c2ccc(Cl)cc2)/N1C)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C07 compound treatment 150400.0 -963.0 -0.04 160520.0 5710.0 0.21 0.125 0.5751 1049317 Maybridge4_002867 OC(=O)CCNC(=O)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C08 compound treatment 160600.0 9240.0 0.36 161960.0 7150.0 0.27 0.4431 0.9898 3064055 Maybridge4_002868 Oc1c([I+]c2ccccc2)c(=O)[nH]c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C09 compound treatment 147680.0 -3680.0 -0.14 151760.0 -3050.0 -0.11 -0.1821 -0.994 3064056 Maybridge4_002869 N#CC(Cc1ccccc1)(Cc2ccccc2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C10 compound treatment 134560.0 -16800.0 -0.65 146800.0 -8010.0 -0.3 -0.6737 -0.9383 1357025 Maybridge4_002870 CC1(C)c2cc(Cl)ccc2-n3c1cc(O)c(c4ccccc4)c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C11 compound treatment 155120.0 3760.0 0.15 148320.0 -6490.0 -0.24 -0.0692 -0.2438 1019915 Maybridge4_002871 Cc1ccc(cc1)C(O)c2nccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C12 compound treatment 14440.0 -137000.0 -5.31 13360.0 -141000.0 -5.31 -7.5106 -1.0 3064058 Maybridge4_002872 O/N=C/C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C13 compound treatment 150760.0 -603.0 -0.02 146360.0 -8450.0 -0.32 -0.2409 -0.7572 3064059 Maybridge4_002873 CC(C)/C(=N/O)/c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C14 compound treatment 146120.0 -5240.0 -0.2 153640.0 -1170.0 -0.04 -0.175 -0.8408 1733383 Maybridge4_002874 CCCCC1(CO)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C15 compound treatment 61280.0 -90100.0 -3.5 121880.0 -32900.0 -1.24 -3.3455 -0.9024 1134906 Maybridge4_002875 NC(=O)NC1C(Oc2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C16 compound treatment 9560.0 -142000.0 -5.5 27400.0 -127000.0 -4.78 -7.2719 -0.9976 1708436 Maybridge4_002876 CSc1[nH]nc(NS(=O)(=O)c2ccc(Cl)cc2)c1c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C17 compound treatment 38200.0 -113000.0 -4.39 48800.0 -106000.0 -3.98 -5.9182 -0.9988 1325632 Maybridge4_002877 CCCCc1c(O)c2cccc3c4ccccc4n(c1=O)c32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C18 compound treatment 164760.0 13400.0 0.52 155120.0 306.0 0.01 0.3757 0.7226 3179393 Maybridge4_002878 O=C1NCCN1CC/N=C/c2ccc(C#N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C19 compound treatment 141240.0 -10100.0 -0.39 154680.0 -134.0 -0.01 -0.2813 -0.7161 3064061 Maybridge4_002879 c1c2ccccc2c3ccc(oc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C20 compound treatment 105160.0 -46200.0 -1.79 149600.0 -5210.0 -0.2 -1.406 -0.7797 1357662 Maybridge4_002880 CC(C)c1ccc(NN2C(=O)CC(C2=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C21 compound treatment 13600.0 -138000.0 -5.35 46000.0 -109000.0 -4.08 -6.6674 -0.9912 1704922 Maybridge4_002881 COc1cc(C)c2C3CCC4(C)C(O)CCC4C3CCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C22 compound treatment 167160.0 15800.0 0.61 166560.0 11700.0 0.44 0.7452 0.9869 1187010 Maybridge4_002882 Fc1ccc(C(=O)OCCn2ncc3ccccc3c2=O)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C23 mock treatment 167480.0 16100.0 0.63 148360.0 -6450.0 -0.24 0.2709 0.404 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 C24 mock treatment 182600.0 31200.0 1.21 147440.0 -7370.0 -0.28 0.6613 0.532 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D01 compound treatment 153080.0 1720.0 0.07 173680.0 18900.0 0.71 0.5478 0.7703 1248994 Maybridge4_002883 CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)CSCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D02 compound treatment 141400.0 -9960.0 -0.39 165600.0 10800.0 0.4 0.0129 0.0231 3064062 Maybridge4_002884 Cc1ccc(/N=C/2\SC3(CC3)C(=O)N2c4ccc(C)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D03 compound treatment 109760.0 -41600.0 -1.61 120320.0 -34500.0 -1.29 -2.0568 -0.994 3179394 Maybridge4_002885 Clc1cccc(c1)/C(=C/C=C/c2ccccc2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D04 compound treatment 110680.0 -40700.0 -1.58 132880.0 -21900.0 -0.82 -1.6983 -0.9539 3064063 Maybridge4_002886 Clc1cccc(/N=C/2\SC3(CC3)C(=O)N2c4cccc(Cl)c4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D05 compound treatment 154240.0 2880.0 0.11 188840.0 34000.0 1.28 0.982 0.766 3179395 Maybridge4_002887 CCc1nn(C)c2c(=O)c(=O)c2n(C)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D06 compound treatment 140480.0 -10900.0 -0.42 180720.0 25900.0 0.97 0.389 0.3669 3064064 Maybridge4_002888 CC1=NNC(=O)C1Oc2ccc(Cl)cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D07 compound treatment 147800.0 -3560.0 -0.14 162280.0 7470.0 0.28 0.1004 0.3213 3179396 Maybridge4_002889 CSC(=N)Nc1c(Cl)cccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D08 compound treatment 115200.0 -36200.0 -1.4 179000.0 24200.0 0.91 -0.3503 -0.2096 3179397 Maybridge4_002890 Cc1nc(nc(NCCNc2ccc(cn2)C(F)(F)F)c1Cl)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D09 compound treatment 147440.0 -3920.0 -0.15 153440.0 -1370.0 -0.05 -0.1441 -0.8966 3064065 Maybridge4_002891 Cc1cc(O)nc(SCC(=O)c2ccc(F)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D10 compound treatment 167800.0 16400.0 0.64 158120.0 3310.0 0.12 0.5387 0.8291 1513804 Maybridge4_002892 CCOC(=O)c1c(C)c(ccc1N(C)C)C2NC(=O)NC=C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D11 compound treatment 159280.0 7920.0 0.31 190400.0 35600.0 1.34 1.1616 0.8476 3064066 Maybridge4_002893 O=C(CSc1nc2ccccc2c(=O)n1Cc3ccco3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D12 compound treatment 145920.0 -5440.0 -0.21 153080.0 -1730.0 -0.07 -0.1953 -0.884 3179501 Maybridge4_002894 CC(C)(C)c1ccc(cc1)/C(=N/O)/N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D13 compound treatment 106960.0 -44400.0 -1.72 121560.0 -33300.0 -1.25 -2.1007 -0.9875 1669360 Maybridge4_002895 Clc1ccc(cc1)C(=O)Nc2cc(Cl)ccc2C(=O)OCC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D14 compound treatment 153360.0 2000.0 0.08 216560.0 61700.0 2.32 1.6935 0.7303 3064067 Maybridge4_002896 CC(C)Nc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D15 compound treatment 152840.0 1480.0 0.06 165480.0 10700.0 0.4 0.3236 0.8002 3064068 Maybridge4_002897 S=C(NC1CCCCC1)N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D16 compound treatment 150360.0 -1000.0 -0.04 158000.0 3190.0 0.12 0.0571 0.4537 1715674 Maybridge4_002898 CN(C)c1nc(cc2C(=O)NC(=O)c21)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D17 compound treatment 153880.0 2520.0 0.1 160120.0 5310.0 0.2 0.2099 0.9462 3064069 Maybridge4_002899 CN(C)/C(=N/c1cc(C)c(C)cc1C)/NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D18 compound treatment 137880.0 -13500.0 -0.52 143440.0 -11400.0 -0.43 -0.6718 -0.9949 3179502 Maybridge4_002900 COc1ccc(/N=c/2\scc(C)n2C(=O)c3ccccc3Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D19 compound treatment 177120.0 25800.0 1.0 171200.0 16400.0 0.62 1.1416 0.9728 1153907 Maybridge4_002901 COc1ccc(OCC(O)CNC(C)(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D20 compound treatment 131360.0 -20000.0 -0.78 141120.0 -13700.0 -0.51 -0.9122 -0.98 3064070 Maybridge4_002902 Clc1cccc(Cl)c1c2cc(on2)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D21 compound treatment 175720.0 24400.0 0.95 186120.0 31300.0 1.17 1.4991 0.9942 1636805 Maybridge4_002903 Brc1ccc(OCC2CN(C(=O)O2)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D22 compound treatment 156440.0 5080.0 0.2 180320.0 25500.0 0.96 0.8162 0.8351 3064071 Maybridge4_002904 CC(C)c1nc(/N=C/N(C)C)nc(=O)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D23 mock treatment 187160.0 35800.0 1.39 149440.0 -5370.0 -0.2 0.8395 0.5982 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 D24 mock treatment 153960.0 2600.0 0.1 159120.0 4310.0 0.16 0.1855 0.9742 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E01 compound treatment 174200.0 22800.0 0.89 151960.0 -2850.0 -0.11 0.5508 0.6171 3179503 Maybridge4_002905 O=C(CSc1ccccn1)Nc2ccccc2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E02 compound treatment 92800.0 -58600.0 -2.27 111160.0 -43700.0 -1.64 -2.7652 -0.9871 3179504 Maybridge4_002906 N#CC1(N=C2C=CC=CN2N=C1c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E03 compound treatment 120960.0 -30400.0 -1.18 106560.0 -48300.0 -1.81 -2.1147 -0.9784 3064072 Maybridge4_002907 O=C1OC2(CCCCC2)OC(=O)C1=Cc3ccoc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E04 compound treatment 41800.0 -110000.0 -4.25 41840.0 -113000.0 -4.24 -6.0042 -1.0 3179505 Maybridge4_002908 FC(F)(F)c1cc(nc(S/C=C/C(=O)c2ccccc2)c1C#N)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E05 compound treatment 368120.0 217000.0 8.41 152240.0 -2570.0 -0.1 5.8786 0.6989 3064073 Maybridge4_002909 CNS(=O)(=O)c1ccc(Br)cc1I 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E06 compound treatment 147680.0 -3680.0 -0.14 175480.0 20700.0 0.78 0.4474 0.5673 3179506 Maybridge4_002910 CC(=O)O[C@@H]1O[C@@H]2CO[C@H](O[C@H]2[C@H](OC(=O)C)[C@H]1OC(=O)C)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E07 compound treatment 144240.0 -7120.0 -0.28 165480.0 10700.0 0.4 0.0877 0.1802 1547193 Maybridge4_002911 CCNS(=O)(=O)c1cccc2c(N)cccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E08 compound treatment 170320.0 19000.0 0.74 161960.0 7150.0 0.27 0.7098 0.9066 1448662 Maybridge4_002912 CCc1c(O)c(Cc2ccccc2)c(=O)n(c3nccs3)c1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E09 compound treatment 156040.0 4680.0 0.18 167920.0 13100.0 0.49 0.4762 0.9082 3179507 Maybridge4_002913 CCOC(=O)C(C#N)C1(C(=NN(C1=O)c2ccccc2)C)c3c(C)nn(c3O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E10 compound treatment 13200.0 -138000.0 -5.36 14960.0 -140000.0 -5.25 -7.5022 -0.9999 3064074 Maybridge4_002914 Fc1ccc(cc1)C(=O)/C=C/S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E11 compound treatment 113960.0 -37400.0 -1.45 152600.0 -2210.0 -0.08 -1.0849 -0.7464 1495930 Maybridge4_002915 CC(C)C(OC(=O)c1ccccc1)c2nccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E12 compound treatment 149640.0 -1720.0 -0.07 150320.0 -4490.0 -0.17 -0.1665 -0.9179 1260619 Maybridge4_002916 COC(=O)c1sc2c(C)cc(Cl)c(C)c2c1C(=O)Oc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E13 compound treatment 149640.0 -1720.0 -0.07 147800.0 -7010.0 -0.26 -0.2334 -0.8594 1268159 Maybridge4_002917 CCn1c(=O)cc(O)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E14 compound treatment 153880.0 2520.0 0.1 150560.0 -4250.0 -0.16 -0.0438 -0.2341 1134720 Maybridge4_002918 CCCCC1(COC(=O)c2ccc(OC)cc2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E15 compound treatment 150520.0 -843.0 -0.03 199560.0 44700.0 1.68 1.1644 0.6932 3063981 Maybridge4_002919 Clc1cc(Cl)c2c(=O)cc(oc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E16 compound treatment 135160.0 -16200.0 -0.63 133440.0 -21400.0 -0.8 -1.0118 -0.9927 3063982 Maybridge4_002920 O=C(CSc1nc(SCC(=O)c2ccccc2)c3ccccc3n1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E17 compound treatment 28200.0 -123000.0 -4.78 40560.0 -114000.0 -4.29 -6.4113 -0.9985 1617223 Maybridge4_002921 Oc1c(Cc2ccccc2)c(=O)n3c4ccccc4c5cccc1c53 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E18 compound treatment 102080.0 -49300.0 -1.91 143040.0 -11800.0 -0.44 -1.6646 -0.8482 3063983 Maybridge4_002922 Clc1ccc(CCN2C(=O)CSC2=S)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E19 compound treatment 98080.0 -53300.0 -2.07 138360.0 -16500.0 -0.62 -1.8985 -0.8799 3179508 Maybridge4_002923 CCc1c(C)oc2cc3ccccc3c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E20 compound treatment 102600.0 -48800.0 -1.89 165080.0 10300.0 0.39 -1.0654 -0.5518 1212790 Maybridge4_002924 O=C(CSc1nc2ccccc2c(=O)[nH]1)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E21 compound treatment 150640.0 -723.0 -0.03 143200.0 -11600.0 -0.44 -0.328 -0.751 3179509 Maybridge4_002925 CC(OC(=O)C)C1CCC2C3CC[C@H]4CC(=O)CCC4(C)C3CCC12C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E22 compound treatment 153000.0 1640.0 0.06 204600.0 49800.0 1.87 1.3662 0.7307 1296117 Maybridge4_002926 O=C(OCCn1ncc2ccccc2c1=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E23 mock treatment 165560.0 14200.0 0.55 155880.0 1070.0 0.04 0.4178 0.7565 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 E24 mock treatment 148240.0 -3120.0 -0.12 158720.0 3910.0 0.15 0.018 0.0946 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F01 compound treatment 133960.0 -17400.0 -0.68 160200.0 5390.0 0.2 -0.3345 -0.4746 1646144 Maybridge4_002927 CCCCC1(CN2CCN(Cc3ccccc3)CC2)C(=O)N(N(C1=O)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F02 compound treatment 171400.0 20000.0 0.78 179000.0 24200.0 0.91 1.1916 0.997 1353488 Maybridge4_002928 OC(COc1ccc(F)cc1)CS(=O)(=O)Cc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F03 compound treatment 99640.0 -51700.0 -2.01 101760.0 -53100.0 -1.99 -2.827 -1.0 3064021 Maybridge4_002929 CCc1ccc(cc1)/C(=C/C=C/c2ccccc2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F04 compound treatment 125200.0 -26200.0 -1.02 139520.0 -15300.0 -0.57 -1.1237 -0.9636 1107774 Maybridge4_002930 Fc1ccc(NC(=S)C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F05 compound treatment 147720.0 -3640.0 -0.14 204600.0 49800.0 1.87 1.2213 0.6518 1733993 Maybridge4_002931 CCc1cccc(CC)c1NC(=S)Nc2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F06 compound treatment 165080.0 13700.0 0.53 165280.0 10500.0 0.39 0.6541 0.9888 3179510 Maybridge4_002932 FC(F)(F)c1ccc(cc1)C(=O)Nc2ccc(cc2)C3=NCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F07 compound treatment 15320.0 -136000.0 -5.28 26200.0 -129000.0 -4.83 -7.1457 -0.999 3064024 Maybridge4_002933 Cc1cccc(Cl)c1NC(=S)NC(Cc2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F08 compound treatment 144000.0 -7360.0 -0.29 155600.0 786.0 0.03 -0.1811 -0.6307 1491434 Maybridge4_002934 C1CN(CCO1)c2nc(ns2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F09 compound treatment 164320.0 13000.0 0.5 166000.0 11200.0 0.42 0.6524 0.996 1641045 Maybridge4_002935 CC(C)(CO)NC(=S)NCC1CCCO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F10 compound treatment 159920.0 8560.0 0.33 152640.0 -2170.0 -0.08 0.1771 0.518 3179511 Maybridge4_002936 O/N=C/c1c(F)cccc1F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F11 compound treatment 132320.0 -19000.0 -0.74 162920.0 8110.0 0.3 -0.3073 -0.3846 3179512 Maybridge4_002937 Sc1nc2ccccc2c(=O)n1c3ccc(Cl)c(Cl)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F12 compound treatment 155720.0 4360.0 0.17 154880.0 66.3 0.0 0.1213 0.7174 3064025 Maybridge4_002938 Cc1cc(nn1c2ccccc2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F13 compound treatment 153000.0 1640.0 0.06 158760.0 3950.0 0.15 0.1497 0.9286 3064027 Maybridge4_002939 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F14 compound treatment 172760.0 21400.0 0.83 174200.0 19400.0 0.73 1.1016 0.9978 3179513 Maybridge4_002940 CC(C)Sc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F15 compound treatment 42040.0 -109000.0 -4.24 72760.0 -82100.0 -3.08 -5.177 -0.9876 3179514 Maybridge4_002941 CCOC(=O)c1ccc(NC(=N)SCc2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F16 compound treatment 11920.0 -139000.0 -5.41 15400.0 -139000.0 -5.23 -7.5256 -0.9999 3064028 Maybridge4_002942 Cc1onc(c1N)c2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F17 compound treatment 148240.0 -3120.0 -0.12 159760.0 4950.0 0.19 0.0456 0.2057 3064029 Maybridge4_002943 Cc1cc(C)c(NC(=N)NN)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F18 compound treatment 148400.0 -2960.0 -0.11 175160.0 20300.0 0.76 0.4587 0.594 3179515 Maybridge4_002944 COC(=O)c1c(noc1C(=O)NN)c2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F19 compound treatment 127680.0 -23700.0 -0.92 127080.0 -27700.0 -1.04 -1.3858 -0.9981 1249379 Maybridge4_002945 COc1c(Cl)cccc1c2cn3ccc(C)cc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F20 compound treatment 149400.0 -1960.0 -0.08 191640.0 36800.0 1.38 0.9235 0.6671 1721352 Maybridge4_002946 Oc1nsc(Nc2ccccc2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F21 compound treatment 169920.0 18600.0 0.72 149160.0 -5650.0 -0.21 0.3591 0.4784 1132779 Maybridge4_002947 COc1ccc(COCC(O)CS(=O)(=O)c2ccc(OC)c(OC)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F22 compound treatment 152080.0 718.0 0.03 180360.0 25500.0 0.96 0.6977 0.7273 3064075 Maybridge4_002948 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F23 mock treatment 151040.0 -323.0 -0.01 153440.0 -1370.0 -0.05 -0.0453 -0.8539 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 F24 mock treatment 166880.0 15500.0 0.6 177760.0 22900.0 0.86 1.0347 0.9847 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G01 compound treatment 136680.0 -14700.0 -0.57 152720.0 -2090.0 -0.08 -0.4584 -0.7971 1511541 Maybridge4_002949 Fc1ccc(NC(=O)C(=S)NC2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G02 compound treatment 117880.0 -33500.0 -1.3 145680.0 -9130.0 -0.34 -1.161 -0.8641 1391130 Maybridge4_002950 Clc1ccc(Nc2nnc3c4ccccc4c5ccccc5c3n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G03 compound treatment 136360.0 -15000.0 -0.58 145120.0 -9690.0 -0.36 -0.6689 -0.9744 3179516 Maybridge4_002951 CC1C(=NN(C1=O)c2ccccc2)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G04 compound treatment 11400.0 -140000.0 -5.43 11440.0 -143000.0 -5.38 -7.645 -1.0 3179517 Maybridge4_002952 Cc1ccc2[nH]c(S/C=C/C(=O)c3ccccc3)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G05 compound treatment 131720.0 -19600.0 -0.76 135320.0 -19500.0 -0.73 -1.0563 -0.9998 1247714 Maybridge4_002953 CNS(=O)(=O)c1c(I)ccc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G06 compound treatment 138720.0 -12600.0 -0.49 163080.0 8270.0 0.31 -0.1275 -0.2196 3179612 Maybridge4_002954 CC(=O)N1[C@H](SC(C)(C)[C@@H]1C(=O)O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G07 compound treatment 141960.0 -9400.0 -0.36 134600.0 -20200.0 -0.76 -0.7944 -0.9437 1286617 Maybridge4_002955 COc1cc2OC(C)(C)CC(=O)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G08 compound treatment 145960.0 -5400.0 -0.21 143960.0 -10900.0 -0.41 -0.4363 -0.9523 3179613 Maybridge4_002956 CC(=O)OC(C#N)[C@H]1O[C@@H]2OC(C)(C)O[C@@H]2[C@H]1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G09 compound treatment 145480.0 -5880.0 -0.23 147200.0 -7610.0 -0.29 -0.3635 -0.9938 3064077 Maybridge4_002957 OC(=O)CCc1n[nH]c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G10 compound treatment 157440.0 6080.0 0.24 160960.0 6150.0 0.23 0.3299 0.9999 3064078 Maybridge4_002958 Cc1c(cnn1c2ccccc2)c3nnnn3c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G11 compound treatment 133680.0 -17700.0 -0.69 142400.0 -12400.0 -0.47 -0.8146 -0.9822 3179614 Maybridge4_002959 O=S(CC#N)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G12 compound treatment 168160.0 16800.0 0.65 179120.0 24300.0 0.91 1.1059 0.9864 3179615 Maybridge4_002960 FC(F)(F)c1cccc(OC(=O)c2cc3ccc4ccccc4c3s2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G13 compound treatment 58720.0 -92600.0 -3.59 59360.0 -95500.0 -3.58 -5.075 -1.0 3064081 Maybridge4_002961 CC(C)CC(C(O)c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G14 compound treatment 122480.0 -28900.0 -1.12 116920.0 -37900.0 -1.42 -1.7981 -0.993 1388837 Maybridge4_002962 CCCCC1(COC(=O)Nc2cccc(Cl)c2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G15 compound treatment 139960.0 -11400.0 -0.44 148560.0 -6250.0 -0.23 -0.4788 -0.956 3064082 Maybridge4_002963 NC1=NC(C(N1)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G16 compound treatment 144880.0 -6480.0 -0.25 144680.0 -10100.0 -0.38 -0.4468 -0.9798 3179616 Maybridge4_002964 CSc1nc2ccccc2c(=O)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G17 compound treatment 152360.0 998.0 0.04 168960.0 14100.0 0.53 0.4028 0.7566 3179617 Maybridge4_002965 O=c1ss/c(=N/Cc2ccccc2)/n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G18 compound treatment 117200.0 -34200.0 -1.33 133880.0 -20900.0 -0.79 -1.4928 -0.9688 3064083 Maybridge4_002966 S=C(NCC1CC1)NCc2csc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G19 compound treatment 138240.0 -13100.0 -0.51 156720.0 1910.0 0.07 -0.3094 -0.6018 1378931 Maybridge4_002967 C(NC1CCCCC1)C(CNC2CCCCC2)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G20 compound treatment 124280.0 -27100.0 -1.05 141320.0 -13500.0 -0.51 -1.1011 -0.944 3064084 Maybridge4_002968 CC(C)(C)c1ccc(NC(=O)c2cnccn2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G21 compound treatment 128440.0 -22900.0 -0.89 139440.0 -15400.0 -0.58 -1.0369 -0.9781 1050158 Maybridge4_002969 COc1ccc2C3CCC4(C)C(CCC4=O)C3CCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G22 compound treatment 17080.0 -134000.0 -5.21 16480.0 -138000.0 -5.19 -7.3554 -1.0 1218870 Maybridge4_002970 O=C(Nc1cccnc1)c2cc3CCc4ccccc4-c3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G23 mock treatment 138840.0 -12500.0 -0.49 147240.0 -7570.0 -0.28 -0.5446 -0.9674 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 G24 mock treatment 146760.0 -4600.0 -0.18 148800.0 -6010.0 -0.23 -0.2859 -0.9933 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H01 compound treatment 138640.0 -12700.0 -0.49 152000.0 -2810.0 -0.11 -0.4237 -0.8394 1264780 Maybridge4_002971 COc1ccc(NC(=O)C2CC(=C(C)CC2C(=O)O)C)c(n1)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H02 compound treatment 130840.0 -20500.0 -0.8 160760.0 5950.0 0.22 -0.4052 -0.49 1569864 Maybridge4_002972 COc1ccc(COCC(O)CS(=O)(=O)Cc2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H03 compound treatment 130720.0 -20600.0 -0.8 156080.0 1270.0 0.05 -0.5327 -0.664 1169171 Maybridge4_002973 OCCNN1C(=O)c2cccc3cccc(C1=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H04 compound treatment 142160.0 -9200.0 -0.36 163120.0 8310.0 0.31 -0.032 -0.0676 1600308 Maybridge4_002974 Cc1onc(c1C2=NCCO2)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H05 compound treatment 125200.0 -26200.0 -1.02 133120.0 -21700.0 -0.81 -1.2935 -0.994 3179618 Maybridge4_002975 Cc1cccc(C)c1Nc2nc3c(C)cc(C)c(C)c3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H06 compound treatment 127080.0 -24300.0 -0.94 136040.0 -18800.0 -0.7 -1.1644 -0.9898 1417835 Maybridge4_002976 OC1CCCCC1S(=O)(=O)Cc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H07 compound treatment 91480.0 -59900.0 -2.32 84080.0 -70700.0 -2.65 -3.5201 -0.9978 3064223 Maybridge4_002977 CCC(CO)NC(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H08 compound treatment 140440.0 -10900.0 -0.42 151040.0 -3770.0 -0.14 -0.3998 -0.8948 3179619 Maybridge4_002978 Clc1ccc2oc(=S)n(Cc3ccccc3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H09 compound treatment 136720.0 -14600.0 -0.57 149120.0 -5690.0 -0.21 -0.5528 -0.9108 3064225 Maybridge4_002979 CNC(=S)NCCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H10 compound treatment 145200.0 -6160.0 -0.24 143400.0 -11400.0 -0.43 -0.472 -0.9621 3179620 Maybridge4_002980 O=C(OCc1ccc2OCOc2c1)OCc3ccc4OCOc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H11 compound treatment 151120.0 -243.0 -0.01 137640.0 -17200.0 -0.64 -0.4624 -0.7174 3179621 Maybridge4_002981 Cc1cc(C)nc(NC(=S)c2ccc(NC(=O)/C=C/C(=O)O)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H12 compound treatment 136280.0 -15100.0 -0.59 151360.0 -3450.0 -0.13 -0.5055 -0.8433 3064227 Maybridge4_002982 NC(=N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H13 compound treatment 137800.0 -13600.0 -0.53 152200.0 -2610.0 -0.1 -0.4415 -0.8247 1447884 Maybridge4_002983 COc1cccc(C(=O)OCC(=O)c2ccccc2)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H14 compound treatment 146800.0 -4560.0 -0.18 160400.0 5590.0 0.21 0.0231 0.0841 3179622 Maybridge4_002984 CCOC(=O)c1cc(nc(S)c1C#N)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H15 compound treatment 129920.0 -21400.0 -0.83 123960.0 -30900.0 -1.16 -1.4071 -0.9868 2077819 Maybridge4_002985 C[n+]1c(NC2CCCCC2)scc1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H16 compound treatment 133280.0 -18100.0 -0.7 150640.0 -4170.0 -0.16 -0.6069 -0.8442 1009495 Maybridge4_002986 CC(C)(C)C1=CC(=O)C(=CC1=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H17 compound treatment 124520.0 -26800.0 -1.04 150920.0 -3890.0 -0.15 -0.8398 -0.7985 3179623 Maybridge4_002987 CCc1ccc(NC(=N)NC(=N)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H18 compound treatment 145920.0 -5440.0 -0.21 135560.0 -19300.0 -0.72 -0.6603 -0.8771 1395086 Maybridge4_002988 Cc1nc(nc(O)c1Cl)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H19 compound treatment 128960.0 -22400.0 -0.87 151560.0 -3250.0 -0.12 -0.701 -0.7986 1725570 Maybridge4_002989 CC(C)(C)C(=O)Nc1ccc(cc1)c2cc3cc(Cl)ccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H20 compound treatment 57720.0 -93600.0 -3.63 67160.0 -87700.0 -3.29 -4.8954 -0.9988 1661405 Maybridge4_002990 Cc1ccc(NC(=S)C(C#N)C(=O)N)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H21 compound treatment 153560.0 2200.0 0.09 148800.0 -6010.0 -0.23 -0.0993 -0.4116 1723738 Maybridge4_002991 Clc1ccc(N2C(CC(=O)NC2=S)c3ccccc3)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H22 compound treatment 134440.0 -16900.0 -0.66 135880.0 -18900.0 -0.71 -0.9668 -0.9992 3179624 Maybridge4_002992 OCc1noc(n1)c2ccc(Cl)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H23 mock treatment 144760.0 -6600.0 -0.26 161880.0 7070.0 0.27 0.0064 0.0173 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 H24 mock treatment 139640.0 -11700.0 -0.45 148080.0 -6730.0 -0.25 -0.5003 -0.9615 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I01 compound treatment 46640.0 -105000.0 -4.06 67920.0 -86900.0 -3.26 -5.1792 -0.9941 1401560 Maybridge4_002993 Clc1ccc(NC(=O)Nc2ccccc2)c(SCc3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I02 compound treatment 157640.0 6280.0 0.24 135880.0 -18900.0 -0.71 -0.3303 -0.4396 1509609 Maybridge4_002994 CCSc1nnc2nc3c4ccccc4c5ccccc5c3nn12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I03 compound treatment 10600.0 -141000.0 -5.46 11760.0 -143000.0 -5.37 -7.6584 -1.0 3179625 Maybridge4_002995 O=C/1N(N=C(Nc2ccccc2)\C1=C\Nc3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I04 compound treatment 12480.0 -139000.0 -5.39 14040.0 -141000.0 -5.28 -7.5464 -1.0 3064579 Maybridge4_002996 Cn1cnnc1S/C=C/C(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I05 compound treatment 131360.0 -20000.0 -0.78 154000.0 -814.0 -0.03 -0.5704 -0.7344 1063036 Maybridge4_002997 COc1cc(c(OC)cc1C(C)(C)C)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I06 compound treatment 134760.0 -16600.0 -0.64 153120.0 -1690.0 -0.06 -0.5005 -0.7731 3179626 Maybridge4_002998 CSc1ccc(cc1)C2N[C@@H](C(=O)O)C(C)(C)S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I07 compound treatment 119440.0 -31900.0 -1.24 110720.0 -44100.0 -1.65 -2.046 -0.9898 1248980 Maybridge4_002999 CCNS(=O)(=O)c1ccc(cc1)c2oc3cc(ccc3c2Cl)S(=O)(=O)NCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I08 compound treatment 217360.0 66000.0 2.56 149320.0 -5490.0 -0.21 1.6649 0.6481 3064580 Maybridge4_003000 O=C/1N2CCCCSC2=N\C1=C\c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I09 compound treatment 167960.0 16600.0 0.64 170720.0 15900.0 0.6 0.8775 0.9993 1326747 Maybridge4_003001 CN(C)c1ccc(cc1)C2Nc3[nH]nc(C)c3C4=C2C(=O)CCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I10 compound treatment 159960.0 8600.0 0.33 150520.0 -4290.0 -0.16 0.1219 0.3291 3179627 Maybridge4_003002 S=c1[nH]nc(c2ccccc2)c(c1C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I11 compound treatment 150160.0 -1200.0 -0.05 145600.0 -9210.0 -0.35 -0.2775 -0.7953 3063889 Maybridge4_003003 COc1ccc2CC(=O)CCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I12 compound treatment 137640.0 -13700.0 -0.53 130520.0 -24300.0 -0.91 -1.0212 -0.9672 1333404 Maybridge4_003004 CCCC1C2C(ON1c3ccc(Cl)c(Cl)c3)C(=O)N(C2=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I13 compound treatment 162120.0 10800.0 0.42 178040.0 23200.0 0.87 0.9115 0.9431 3063891 Maybridge4_003005 CC(C)CC(C(=O)c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I14 compound treatment 127000.0 -24400.0 -0.95 142920.0 -11900.0 -0.45 -0.9841 -0.9413 1366549 Maybridge4_003006 Clc1cc(Cl)cc(c1)N2C(=O)CC(C2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I15 compound treatment 160320.0 8960.0 0.35 169880.0 15100.0 0.57 0.6456 0.9727 1552090 Maybridge4_003007 O=c1c(coc2ccccc12)c3nnn[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I16 compound treatment 157280.0 5920.0 0.23 149920.0 -4890.0 -0.18 0.0325 0.1105 1232818 Maybridge4_003008 CSc1nc2ccccc2c(=O)n1CC(=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I17 compound treatment 140840.0 -10500.0 -0.41 146040.0 -8770.0 -0.33 -0.5215 -0.9943 3063892 Maybridge4_003009 COc1cc2ccc(=O)oc2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I18 compound treatment 141680.0 -9680.0 -0.38 146600.0 -8210.0 -0.31 -0.4836 -0.9952 3063893 Maybridge4_003010 CN/1\C(=N/C(=O)C)\NC(=O)\C1=C/c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I19 compound treatment 137160.0 -14200.0 -0.55 148920.0 -5890.0 -0.22 -0.5461 -0.9196 1630014 Maybridge4_003011 NC(CCc1ccccc1Cl)c2ccc3OCCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I20 compound treatment 148280.0 -3080.0 -0.12 185600.0 30800.0 1.16 0.7325 0.6305 1530797 Maybridge4_003012 CCC1(CC)COC2(OC1)C(=O)Nc3ccc(F)cc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I21 compound treatment 67440.0 -83900.0 -3.26 44920.0 -110000.0 -4.12 -5.219 -0.9932 3063895 Maybridge4_003013 Cc1cc(oc2cc3ccccc3c12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I22 compound treatment 141120.0 -10200.0 -0.4 141400.0 -13400.0 -0.5 -0.637 -0.9931 3179717 Maybridge4_003014 Cc1cccc(c1)n2ncc3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I23 mock treatment 148680.0 -2680.0 -0.1 155800.0 986.0 0.04 -0.0474 -0.4293 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 I24 mock treatment 156640.0 5280.0 0.2 146720.0 -8090.0 -0.3 -0.07 -0.1911 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J01 compound treatment 160120.0 8760.0 0.34 152600.0 -2210.0 -0.08 0.1815 0.5189 1715355 Maybridge4_003015 OC(=O)COCC(=O)Nc1cnccn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J02 compound treatment 147000.0 -4360.0 -0.17 167240.0 12400.0 0.47 0.2101 0.4234 1137874 Maybridge4_003016 Cc1cccc(C)c1n2c(n[nH]c2=S)C3CC4CCC3O4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J03 compound treatment 149240.0 -2120.0 -0.08 177080.0 22300.0 0.84 0.5327 0.6344 1593696 Maybridge4_003017 CN(C)N1C(=O)c2cccc3cccc(C1=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J04 compound treatment 147920.0 -3440.0 -0.13 178600.0 23800.0 0.89 0.5368 0.5947 3063897 Maybridge4_003018 CC(=O)Nc1ccc(Br)c(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J05 compound treatment 41920.0 -109000.0 -4.25 34920.0 -120000.0 -4.5 -6.1845 -0.9996 1249809 Maybridge4_003019 CC(C)c1ccc(Nc2nnns2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J06 compound treatment 199120.0 47800.0 1.85 179440.0 24600.0 0.92 1.9638 0.9484 1591476 Maybridge4_003020 CCN(CC)c1nc2ccccc2c(=O)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J07 compound treatment 125440.0 -25900.0 -1.01 121000.0 -33800.0 -1.27 -1.6086 -0.9934 1593840 Maybridge4_003021 CCN(CC)C(=S)Oc1ccccc1C(=O)Nc2ccc(Cl)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J08 compound treatment 156440.0 5080.0 0.2 155560.0 746.0 0.03 0.1591 0.7996 3063932 Maybridge4_003022 Clc1cc(Cl)cc(Oc2nc(ns2)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J09 compound treatment 147000.0 -4360.0 -0.17 142480.0 -12300.0 -0.46 -0.447 -0.9069 1389101 Maybridge4_003023 OC(=O)CCC(=O)Nc1cccc(F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J10 compound treatment 147800.0 -3560.0 -0.14 146520.0 -8290.0 -0.31 -0.3178 -0.9332 3063933 Maybridge4_003024 Cc1nc(S)c(C#N)c(C)c1CCC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J11 compound treatment 156680.0 5320.0 0.21 146000.0 -8810.0 -0.33 -0.088 -0.2258 3179718 Maybridge4_003025 Cc1nnc(Nc2cccc(Cl)c2C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J12 compound treatment 71880.0 -79500.0 -3.08 77640.0 -77200.0 -2.9 -4.2288 -0.9995 3063934 Maybridge4_003026 CNC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J13 compound treatment 29000.0 -122000.0 -4.75 25960.0 -129000.0 -4.84 -6.7768 -1.0 1446584 Maybridge4_003027 Cc1cc(Br)ccc1NC(=S)Nc2cccc(NC(=O)c3ccccc3O)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J14 compound treatment 139120.0 -12200.0 -0.48 141440.0 -13400.0 -0.5 -0.6908 -0.9996 3179719 Maybridge4_003028 CCOC(=O)c1cc(nc(O)c1C#N)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J15 compound treatment 138600.0 -12800.0 -0.5 144200.0 -10600.0 -0.4 -0.6318 -0.9942 3063936 Maybridge4_003029 O=c1cc(nc2scc(c3ccccc3)n12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J16 compound treatment 134520.0 -16800.0 -0.65 106120.0 -48700.0 -1.83 -1.7544 -0.9039 3179720 Maybridge4_003030 CCOC(=O)NC(=S)Nc1ccc(cc1)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J17 compound treatment 133080.0 -18300.0 -0.71 149360.0 -5450.0 -0.2 -0.6463 -0.8754 3063937 Maybridge4_003031 Cc1nc(S)nc(O)c1CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J18 compound treatment 172560.0 21200.0 0.82 159760.0 4950.0 0.19 0.7128 0.8454 3179721 Maybridge4_003032 Sc1nnc([nH]1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J19 compound treatment 123640.0 -27700.0 -1.08 131920.0 -22900.0 -0.86 -1.3682 -0.9938 3063939 Maybridge4_003033 COc1ccc(CCn2c(=S)[nH]c3cc(ccc23)C(F)(F)F)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J20 compound treatment 134240.0 -17100.0 -0.66 144280.0 -10500.0 -0.4 -0.7493 -0.9693 3179722 Maybridge4_003034 N#Cc1ccc(cc1)C2SCCCS2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J21 compound treatment 132160.0 -19200.0 -0.75 139400.0 -15400.0 -0.58 -0.9359 -0.9922 3179723 Maybridge4_003035 FC(F)(F)c1cccc(c1)N2C(CC(=O)NC2=S)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J22 compound treatment 138320.0 -13000.0 -0.51 154040.0 -774.0 -0.03 -0.3784 -0.7465 3063940 Maybridge4_003036 Oc1nnc(n2cccc12)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J23 mock treatment 155920.0 4560.0 0.18 177360.0 22500.0 0.85 0.7234 0.8368 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 J24 mock treatment 158120.0 6760.0 0.26 155920.0 1110.0 0.04 0.2148 0.809 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K01 compound treatment 111720.0 -39600.0 -1.54 92920.0 -61900.0 -2.32 -2.7302 -0.98 1466072 Maybridge4_003037 CC(C)(C)c1ccc(CSCC(=O)Nc2ccccc2C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K02 compound treatment 128800.0 -22600.0 -0.88 120640.0 -34200.0 -1.28 -1.526 -0.9827 1417054 Maybridge4_003038 COc1ccc(Cc2nc(n[nH]c2=S)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K03 compound treatment 142000.0 -9360.0 -0.36 135840.0 -19000.0 -0.71 -0.7604 -0.9512 1566854 Maybridge4_003039 Cc1ccc(C(=O)Nc2ccccc2)c(C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K04 compound treatment 138360.0 -13000.0 -0.5 190480.0 35700.0 1.34 0.5898 0.4123 1404328 Maybridge4_003040 CCC1(CC)C(=O)c2cc3ccccc3cc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K05 compound treatment 128960.0 -22400.0 -0.87 148160.0 -6650.0 -0.25 -0.7912 -0.8749 1489684 Maybridge4_003041 CNC(=O)c1ccccc1Sc2ccccc2C(=O)NC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K06 compound treatment 139160.0 -12200.0 -0.47 136000.0 -18800.0 -0.71 -0.8341 -0.9811 3179724 Maybridge4_003042 NC(=N)/N=C(\N)/Nc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K07 compound treatment 148520.0 -2840.0 -0.11 135880.0 -18900.0 -0.71 -0.5805 -0.8072 3063986 Maybridge4_003043 COC(=O)c1c2ccccc2c(C)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K08 compound treatment 173400.0 22000.0 0.86 160080.0 5270.0 0.2 0.7444 0.8482 3179725 Maybridge4_003044 COc1ccc(/C=C\2/N=C3SC(C)C(=O)N3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K09 compound treatment 188240.0 36900.0 1.43 160040.0 5230.0 0.2 1.1505 0.7966 3063988 Maybridge4_003045 C/C(=C\c1ccccc1)/C(=N/O)/C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K10 compound treatment 154360.0 3000.0 0.12 139240.0 -15600.0 -0.58 -0.3311 -0.5555 3179726 Maybridge4_003046 N#C/C(=C\C(=C\N1CCOCC1)\c2ccccc2)/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K11 compound treatment 151520.0 158.0 0.01 152440.0 -2370.0 -0.09 -0.0587 -0.6571 1700846 Maybridge4_003047 CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n2ccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K12 compound treatment 144360.0 -7000.0 -0.27 154240.0 -574.0 -0.02 -0.2073 -0.7608 1550463 Maybridge4_003048 O=C1CSCC(=O)N1c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K13 compound treatment 142400.0 -8960.0 -0.35 134640.0 -20200.0 -0.76 -0.7813 -0.9377 1209004 Maybridge4_003049 COC(=O)C1=C(O)C2(CC(=C(O)C(C1)(C2)C(=O)O)C(=O)OC)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K14 compound treatment 132800.0 -18600.0 -0.72 140600.0 -14200.0 -0.53 -0.8865 -0.9891 3063990 Maybridge4_003050 FC(F)(F)Oc1ccc(/N=c/2\[nH]c(=O)c3ccccc3o2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K15 compound treatment 151360.0 -2.5 0.0 156880.0 2070.0 0.08 0.0548 0.7062 3179727 Maybridge4_003051 FC(F)(F)c1ccc(Oc2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)nc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K16 compound treatment 149200.0 -2160.0 -0.08 152280.0 -2530.0 -0.1 -0.1266 -0.9981 3063992 Maybridge4_003052 COC(=O)/C=C\1/NCC(CNC1=O)OC(=O)c2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K17 compound treatment 149920.0 -1440.0 -0.06 154080.0 -734.0 -0.03 -0.059 -0.9466 1628564 Maybridge4_003053 C1Cc2nc(ccc2-c3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K18 compound treatment 152120.0 758.0 0.03 145880.0 -8930.0 -0.34 -0.2163 -0.6427 3179728 Maybridge4_003054 CC1CC(CC(C)(C)C1)NC(=S)Nc2ccc(I)cc2F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K19 compound treatment 146120.0 -5240.0 -0.2 158240.0 3430.0 0.13 -0.0529 -0.2198 3063993 Maybridge4_003055 Cn1c(=O)n(C)c2ncn(CCCCn3cnc4n(C)c(=O)n(C)c(=O)c34)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K20 compound treatment 144200.0 -7160.0 -0.28 143080.0 -11700.0 -0.44 -0.5079 -0.9754 3179729 Maybridge4_003056 CSc1cccc(c1)N2C(=O)C3CC=C(C)CC3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K21 compound treatment 132360.0 -19000.0 -0.74 159600.0 4790.0 0.18 -0.3943 -0.5196 1568172 Maybridge4_003057 OCC(C(O)c1ccccc1)N2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K22 compound treatment 45800.0 -106000.0 -4.1 14880.0 -140000.0 -5.25 -6.6099 -0.9924 1396421 Maybridge4_003058 NNC(=O)c1cc2CCc3ccccc3-c2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K23 mock treatment 143440.0 -7920.0 -0.31 140440.0 -14400.0 -0.54 -0.5988 -0.9644 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 K24 mock treatment 144240.0 -7120.0 -0.28 155640.0 826.0 0.03 -0.1735 -0.6238 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L01 compound treatment 136920.0 -14400.0 -0.56 134440.0 -20400.0 -0.76 -0.9369 -0.9883 3179730 Maybridge4_003059 Cc1c(sc2nc(nn12)C(F)(F)F)C(=O)Cc3c(O)c4ccccc4oc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L02 compound treatment 123720.0 -27600.0 -1.07 129880.0 -24900.0 -0.94 -1.4201 -0.9977 3063994 Maybridge4_003060 FC(F)(F)c1cc(cc(c1)C(F)(F)F)N2C(=O)CC3(CCCC3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L03 compound treatment 116440.0 -34900.0 -1.36 121160.0 -33700.0 -1.26 -1.8513 -0.9994 3179731 Maybridge4_003061 CCOc1ccc(Br)cc1/C=N/c2ccc3OCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L04 compound treatment 129480.0 -21900.0 -0.85 155440.0 626.0 0.02 -0.5837 -0.6873 1505741 Maybridge4_003062 CC(C)c1ccc(NS(=O)(=O)c2ccc(cc2)N3C(=O)CCC3=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L05 compound treatment 155160.0 3800.0 0.15 144800.0 -10000.0 -0.38 -0.1616 -0.4002 3064031 Maybridge4_003063 Nc1ccccc1NC(=S)Nc2ccccc2C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L06 compound treatment 149200.0 -2160.0 -0.08 152320.0 -2490.0 -0.09 -0.1255 -0.9985 3064032 Maybridge4_003064 CN(C)c1nc2ccccc2c(=O)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L07 compound treatment 148200.0 -3160.0 -0.12 147200.0 -7610.0 -0.29 -0.2888 -0.9287 3179732 Maybridge4_003065 CCN(CC)C(=S)Oc1ccc(I)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L08 compound treatment 144280.0 -7080.0 -0.27 135360.0 -19500.0 -0.73 -0.7106 -0.9109 3179733 Maybridge4_003066 FC(F)(F)c1cc(Cl)c2nc(cn2c1)C(=O)NC(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L09 compound treatment 153040.0 1680.0 0.07 138640.0 -16200.0 -0.61 -0.3832 -0.6277 1015049 Maybridge4_003067 CC(=O)Nc1ccc(Cl)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L10 compound treatment 145640.0 -5720.0 -0.22 161400.0 6590.0 0.25 0.0178 0.0535 3064035 Maybridge4_003068 CCOC(=O)/C(=N/O)/C1=NN=C(N)SC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L11 compound treatment 143520.0 -7840.0 -0.3 143200.0 -11600.0 -0.44 -0.5234 -0.9846 3179734 Maybridge4_003069 CC(C)Nc1nnc(C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L12 compound treatment 151400.0 37.5 0.0 158320.0 3510.0 0.13 0.0941 0.7149 3064037 Maybridge4_003070 CN(C)C(=O)Nc1cc(C)n(n1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L13 compound treatment 135240.0 -16100.0 -0.63 139360.0 -15500.0 -0.58 -0.8525 -0.9993 3179735 Maybridge4_003071 Cc1cccc(C)c1/N=C/2\NC(C)(CO)CS2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L14 compound treatment 40720.0 -111000.0 -4.29 64320.0 -90500.0 -3.4 -5.4372 -0.9933 1316254 Maybridge4_003072 Cc1cc2C(=O)NC(=O)c2c(Sc3ccc(Cl)cc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L15 compound treatment 151720.0 358.0 0.01 132640.0 -22200.0 -0.83 -0.5787 -0.6952 3064038 Maybridge4_003073 Clc1ccc(cc1)c2csc3nc(cc(=O)n23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L16 compound treatment 140760.0 -10600.0 -0.41 133400.0 -21400.0 -0.8 -0.8592 -0.9516 1158628 Maybridge4_003074 CNC(=O)Nc1ccc(cc1Br)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L17 compound treatment 150200.0 -1160.0 -0.05 138040.0 -16800.0 -0.63 -0.4771 -0.7558 3064039 Maybridge4_003075 FC(F)(F)c1cc(cc(c1)C(F)(F)F)n2c(S)nc3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L18 compound treatment 159000.0 7640.0 0.3 139840.0 -15000.0 -0.56 -0.1878 -0.2957 1188106 Maybridge4_003076 Clc1cccc(Cl)c1c2nscc2NC(=O)NN3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L19 compound treatment 121560.0 -29800.0 -1.16 130240.0 -24600.0 -0.92 -1.4698 -0.9937 3064040 Maybridge4_003077 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2cn3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L20 compound treatment 9280.0 -142000.0 -5.51 8920.0 -146000.0 -5.48 -7.77 -1.0 3178150 Maybridge4_003078 CNC(=O)Oc1ccc(cc1)c2nc(CSc3ccc(Cl)cc3)cs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L21 compound treatment 9040.0 -142000.0 -5.52 7680.0 -147000.0 -5.52 -7.8095 -1.0 1216087 Maybridge4_003079 CC(C)c1ccc(NCC(O)CSc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L22 compound treatment 144160.0 -7200.0 -0.28 46760.0 -108000.0 -4.06 -3.0652 -0.754 3064086 Maybridge4_003080 OCc1nc(cs1)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L23 mock treatment 139880.0 -11500.0 -0.45 148520.0 -6290.0 -0.24 -0.4821 -0.956 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 L24 mock treatment 151240.0 -123.0 0.0 150200.0 -4610.0 -0.17 -0.1258 -0.7262 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M01 compound treatment 134240.0 -17100.0 -0.66 126840.0 -28000.0 -1.05 -1.2122 -0.9756 1228182 Maybridge4_003081 O=C(Nc1ccc2OCOc2c1)C(=S)NCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M02 compound treatment 144760.0 -6600.0 -0.26 158480.0 3670.0 0.14 -0.0838 -0.2883 3064088 Maybridge4_003082 CCOC(=O)CSc1nnc(c2ccccc2)c(=O)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M03 compound treatment 140560.0 -10800.0 -0.42 136040.0 -18800.0 -0.7 -0.7946 -0.9692 3178151 Maybridge4_003083 CC1(C)OC(=O)C(=Cc2ccoc2)C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M04 compound treatment 149120.0 -2240.0 -0.09 153480.0 -1330.0 -0.05 -0.0969 -0.9655 3178152 Maybridge4_003084 C[C@]1(O)CCC2C3CC[C@H]4CC(=O)/C(=C/c5ccccc5)/CC4(C)C3CCC21C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M05 compound treatment 129640.0 -21700.0 -0.84 139600.0 -15200.0 -0.57 -0.9997 -0.982 2077623 Maybridge4_003085 CNC(=O)c1ccccc1[S+]2N(C)C(=O)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M06 compound treatment 126920.0 -24400.0 -0.95 150440.0 -4370.0 -0.16 -0.7867 -0.8173 3064090 Maybridge4_003086 Cc1ccc(cc1)C(=O)/C=C/Nc2ccc(cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M07 compound treatment 148240.0 -3120.0 -0.12 143960.0 -10900.0 -0.41 -0.3737 -0.8793 3064091 Maybridge4_003087 FC(F)(F)C(=O)N1CCCc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M08 compound treatment 150960.0 -403.0 -0.02 149200.0 -5610.0 -0.21 -0.16 -0.7574 3178153 Maybridge4_003088 CN(C)/C=C/C=C/1\N=C(OC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M09 compound treatment 145360.0 -6000.0 -0.23 143680.0 -11100.0 -0.42 -0.4602 -0.9619 1045240 Maybridge4_003089 O(c1ccccc1)c2nc(Oc3ccccc3)nc(Oc4ccccc4)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M10 compound treatment 148880.0 -2480.0 -0.1 133240.0 -21600.0 -0.81 -0.6407 -0.7857 1341049 Maybridge4_003090 Oc1c(Cc2ccccc2)c(=O)n(c3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M11 compound treatment 117640.0 -33700.0 -1.31 128320.0 -26500.0 -0.99 -1.6283 -0.9908 1250198 Maybridge4_003091 CCN1c2cc(NC(=O)CC)ccc2C(C)CC1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M12 compound treatment 134360.0 -17000.0 -0.66 142680.0 -12100.0 -0.46 -0.7885 -0.9836 1276296 Maybridge4_003092 COC(=O)c1cc(=O)n2CCSc2c1C(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M13 compound treatment 167080.0 15700.0 0.61 158200.0 3390.0 0.13 0.5211 0.8365 1660543 Maybridge4_003093 CCC(C)c1cc(N)nc2nc3ccccc3n12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M14 compound treatment 140960.0 -10400.0 -0.4 132160.0 -22700.0 -0.85 -0.8866 -0.942 1341769 Maybridge4_003094 Fc1ccc(cc1)N2C(=O)CC(C2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M15 compound treatment 142360.0 -9000.0 -0.35 136280.0 -18500.0 -0.7 -0.7389 -0.9492 3178154 Maybridge4_003095 CCOC(=O)CCc1c(CC(=O)OCC)c[nH]c1/C=N/O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M16 compound treatment 31040.0 -120000.0 -4.67 17080.0 -138000.0 -5.17 -6.9565 -0.9987 3064093 Maybridge4_003096 OC(=O)c1ccccc1SC(CC(=O)c2ccc(F)cc2)c3ccc(F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M17 compound treatment 162560.0 11200.0 0.43 101320.0 -53500.0 -2.01 -1.1125 -0.5416 3178155 Maybridge4_003097 Clc1ccccc1N/C=C\C2=NN=NC2c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M18 compound treatment 139280.0 -12100.0 -0.47 134840.0 -20000.0 -0.75 -0.8616 -0.9744 3064095 Maybridge4_003098 CN(C)NC(=S)NCc1ccc(F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M19 compound treatment 11760.0 -140000.0 -5.42 8760.0 -146000.0 -5.48 -7.7062 -1.0 3178156 Maybridge4_003099 CC(=O)OC1CCC2C3CC[C@H]4C[C@@H]5C[C@@H]5[C@H](O)C4(C)C3CCC12C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M20 compound treatment 124120.0 -27200.0 -1.06 152640.0 -2170.0 -0.08 -0.8051 -0.7594 1273753 Maybridge4_003100 S=C(N1CCN(Cc2ccccc2)CC1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M21 compound treatment 17600.0 -134000.0 -5.19 13960.0 -141000.0 -5.29 -7.408 -1.0 3064162 Maybridge4_003101 CCOC(=O)/N=C(/c1ccc(Cl)cc1)\c2cc3ccccc3cn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M22 compound treatment 127200.0 -24200.0 -0.94 154520.0 -294.0 -0.01 -0.6707 -0.7154 1623253 Maybridge4_003102 CCOC(=O)CC(Sc1ccccc1N)c2cc(OC)c(OC)c(OC)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M23 mock treatment 155840.0 4480.0 0.17 148680.0 -6130.0 -0.23 -0.0399 -0.1385 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 M24 mock treatment 140000.0 -11400.0 -0.44 152360.0 -2450.0 -0.09 -0.3769 -0.8368 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N01 compound treatment 50880.0 -100000.0 -3.9 68960.0 -85900.0 -3.22 -5.0353 -0.9955 3178157 Maybridge4_003103 CN(C)c1ccc(/C=C(\C#N)/c2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N02 compound treatment 125200.0 -26200.0 -1.02 118320.0 -36500.0 -1.37 -1.6863 -0.9891 3178158 Maybridge4_003104 FC(F)(F)Oc1ccc(OCc2n[nH]c(=S)o2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N03 compound treatment 55680.0 -95700.0 -3.71 11400.0 -143000.0 -5.38 -6.4312 -0.9836 1090055 Maybridge4_003105 CC(C)c1ccc(cc1)N2Cc3cc(ccc3N=C2)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N04 compound treatment 136880.0 -14500.0 -0.56 149880.0 -4930.0 -0.19 -0.5283 -0.8929 3064190 Maybridge4_003106 FC(F)(F)Oc1ccc(OC(=O)C2=Cc3cc(Cl)ccc3OC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N05 compound treatment 130520.0 -20800.0 -0.81 138560.0 -16300.0 -0.61 -1.0032 -0.9903 3178159 Maybridge4_003107 Cc1cc(Cl)ccc1NC(=N)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N06 compound treatment 11640.0 -140000.0 -5.42 11000.0 -144000.0 -5.4 -7.6501 -1.0 3178160 Maybridge4_003108 FC(F)(F)c1cnc(NCCNC(=O)C(F)(F)Sc2ccccc2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N07 compound treatment 135280.0 -16100.0 -0.62 130240.0 -24600.0 -0.92 -1.0934 -0.9819 3064194 Maybridge4_003109 CCN(CC)C(=S)Oc1ccc(C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N08 compound treatment 135600.0 -15800.0 -0.61 143920.0 -10900.0 -0.41 -0.7216 -0.9808 3064195 Maybridge4_003110 CC(C)(C)CC(C)(C)NC(=O)c1cccc(/N=C/c2ccccc2O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N09 compound treatment 11880.0 -139000.0 -5.41 9320.0 -145000.0 -5.46 -7.6881 -1.0 1463402 Maybridge4_003111 CCc1ccccc1NC(=S)Nc2ccc(Oc3ccc(Cl)cc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N10 compound treatment 16240.0 -135000.0 -5.24 11040.0 -144000.0 -5.4 -7.5228 -0.9999 3064198 Maybridge4_003112 Clc1ccc(SC(=S)NC2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N11 compound treatment 13520.0 -138000.0 -5.35 10920.0 -144000.0 -5.4 -7.6006 -1.0 1288025 Maybridge4_003113 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2NCc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N12 compound treatment 141120.0 -10200.0 -0.4 155040.0 226.0 0.01 -0.275 -0.6918 3064199 Maybridge4_003114 OC(=O)c1cc(O)nc2c(cccc12)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N13 compound treatment 98600.0 -52800.0 -2.05 97680.0 -57100.0 -2.14 -2.9639 -0.9997 3178161 Maybridge4_003115 CC1CCCC(C)N1C(=S)NCCCN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N14 compound treatment 131440.0 -19900.0 -0.77 146240.0 -8570.0 -0.32 -0.7741 -0.9246 3178162 Maybridge4_003116 CCOC(=O)c1cc(nc(OC(=O)N(C)C)c1C#N)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N15 compound treatment 122680.0 -28700.0 -1.11 144560.0 -10300.0 -0.38 -1.0591 -0.8994 3064201 Maybridge4_003117 COc1ccc(/N=C/2\SCC(=O)N2CCc3ccc(OC)c(OC)c3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N16 compound treatment 139600.0 -11800.0 -0.46 131560.0 -23300.0 -0.87 -0.9398 -0.9543 3178163 Maybridge4_003118 Clc1cn(CCC#N)cc(Cl)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N17 compound treatment 148800.0 -2560.0 -0.1 127760.0 -27100.0 -1.02 -0.7883 -0.7727 3064203 Maybridge4_003119 CC1=NNC(=O)C1Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N18 compound treatment 136760.0 -14600.0 -0.57 128040.0 -26800.0 -1.0 -1.1112 -0.9632 1440599 Maybridge4_003120 CCOC(=O)Cn1c(noc1=O)c2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N19 compound treatment 134760.0 -16600.0 -0.64 70080.0 -84700.0 -3.18 -2.7043 -0.8334 3178164 Maybridge4_003121 Cc1cc(C)c(OC(=O)/C=C/c2cccs2)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N20 compound treatment 138560.0 -12800.0 -0.5 126360.0 -28500.0 -1.07 -1.1064 -0.9394 3064205 Maybridge4_003122 CSc1nc(NC(=O)NS(=O)(=O)c2ccccc2C(F)(F)F)nc(n1)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N21 compound treatment 15520.0 -136000.0 -5.27 7760.0 -147000.0 -5.52 -7.6296 -0.9997 1468063 Maybridge4_003123 CC(C)c1ccc(NCC(O)COc2ccc(Cl)c(Cl)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N22 compound treatment 132320.0 -19000.0 -0.74 129800.0 -25000.0 -0.94 -1.1863 -0.993 3064206 Maybridge4_003124 O=C1CNC(=S)N1CCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N23 mock treatment 128640.0 -22700.0 -0.88 145800.0 -9010.0 -0.34 -0.8626 -0.9135 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 N24 mock treatment 145120.0 -6240.0 -0.24 141200.0 -13600.0 -0.51 -0.5326 -0.9418 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O01 compound treatment 156240.0 4880.0 0.19 150520.0 -4290.0 -0.16 0.0199 0.0799 1118081 Maybridge4_003125 NNC(=O)CNc1ccc2OCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O02 compound treatment 81280.0 -70100.0 -2.72 21160.0 -134000.0 -5.02 -5.4698 -0.9586 3178165 Maybridge4_003126 CCOC(=O)c1cnc(S/C=C/C(=O)c2ccc(C)cc2)nc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O03 compound treatment 146960.0 -4400.0 -0.17 132520.0 -22300.0 -0.84 -0.7124 -0.8343 1121873 Maybridge4_003127 OC(=O)c1ccccc1S(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O04 compound treatment 40360.0 -111000.0 -4.31 17280.0 -138000.0 -5.16 -6.6955 -0.9959 3064232 Maybridge4_003128 Clc1ccc(cc1)C(=O)O/C=C/C(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O05 compound treatment 145680.0 -5680.0 -0.22 151560.0 -3250.0 -0.12 -0.2423 -0.9612 3178166 Maybridge4_003129 CNC(=O)c1cccc2cccc(Br)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O06 compound treatment 128480.0 -22900.0 -0.89 138520.0 -16300.0 -0.61 -1.0602 -0.9834 3178167 Maybridge4_003130 COc1ccc(cc1)C(=O)/C=C/Nc2ccc(cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O07 compound treatment 157320.0 5960.0 0.23 141760.0 -13100.0 -0.49 -0.183 -0.3378 3064235 Maybridge4_003131 N#CN=C(NC1CCCCC1)NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O08 compound treatment 26400.0 -125000.0 -4.85 24760.0 -130000.0 -4.88 -6.88 -1.0 3178168 Maybridge4_003132 Fc1ccc(cc1)C(=O)/C=C/Sc2nc3cc(Cl)ccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O09 compound treatment 123320.0 -28000.0 -1.09 88400.0 -66400.0 -2.49 -2.5319 -0.9309 1715504 Maybridge4_003133 CN1C(=O)C(Cc2ccccc2)(c3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O10 compound treatment 163000.0 11600.0 0.45 128040.0 -26800.0 -1.0 -0.3913 -0.3552 1565110 Maybridge4_003134 CN(C)C(=O)Oc1cc(C)n(C)c(=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O11 compound treatment 145520.0 -5840.0 -0.23 156240.0 1430.0 0.05 -0.1224 -0.5257 3064240 Maybridge4_003135 C/C=C(\C(=N\O)\C)/c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O12 compound treatment 173840.0 22500.0 0.87 161800.0 6990.0 0.26 0.8021 0.8808 1124022 Maybridge4_003136 CC(=O)n1c(cc(c(C#N)c1=O)c2ccc(C)cc2)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O13 compound treatment 119960.0 -31400.0 -1.22 121160.0 -33700.0 -1.26 -1.7547 -0.9998 1736617 Maybridge4_003137 COc1ccc(cc1)c2nc([nH]c(=O)c2C#N)N(C)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O14 compound treatment 11120.0 -140000.0 -5.44 10400.0 -144000.0 -5.42 -7.6803 -1.0 3178250 Maybridge4_003138 FC(F)(F)c1ccc(/C=C(\C#N)/c2c[nH]c3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O15 compound treatment 138360.0 -13000.0 -0.5 138440.0 -16400.0 -0.61 -0.7913 -0.9952 1429244 Maybridge4_003139 CCOC(=O)Cc1c(C)[nH]c(C(=O)OCC)c1CC(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O16 compound treatment 104000.0 -47400.0 -1.84 60640.0 -94200.0 -3.53 -3.7987 -0.9536 1373405 Maybridge4_003140 CC(=O)SC1CC(=O)N(C1=O)c2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O17 compound treatment 127040.0 -24300.0 -0.94 123840.0 -31000.0 -1.16 -1.4893 -0.9946 3178251 Maybridge4_003141 O=C(C/C(=C\1/Cc2ccccc2C1=O)/c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O18 compound treatment 155080.0 3720.0 0.14 151400.0 -3410.0 -0.13 0.0114 0.0591 3064242 Maybridge4_003142 CN(C)NC(=S)NCc1ccc(C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O19 compound treatment 10320.0 -141000.0 -5.47 7560.0 -147000.0 -5.53 -7.7776 -1.0 3178252 Maybridge4_003143 CCOC(=O)OC1CCC2C3CCC4=CC(=O)C(=C)CC4(C)C3CCC12C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O20 compound treatment 110160.0 -41200.0 -1.6 51800.0 -103000.0 -3.87 -3.8643 -0.9236 1442612 Maybridge4_003144 Cc1cc(NCn2ncc3ccccc3c2=O)ccc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O21 compound treatment 139040.0 -12300.0 -0.48 129360.0 -25500.0 -0.96 -1.0136 -0.9488 3178253 Maybridge4_003145 Brc1ccc(cc1)c2cnc(/C=C/C=C/N3CCOCC3)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O22 compound treatment 152560.0 1200.0 0.05 131240.0 -23600.0 -0.88 -0.5928 -0.6691 1286622 Maybridge4_003146 O=C1c2ccccc2-c3c1c4ccccc4c(=O)n3CC5CC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O23 mock treatment 140320.0 -11000.0 -0.43 165520.0 10700.0 0.4 -0.0188 -0.0321 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 O24 mock treatment 138440.0 -12900.0 -0.5 147360.0 -7450.0 -0.28 -0.5524 -0.962 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P01 compound treatment 92160.0 -59200.0 -2.3 101440.0 -53400.0 -2.0 -3.0408 -0.9977 3178254 Maybridge4_003147 COc1ccc(/C=C(\C#N)/c2ccc(OC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P02 compound treatment 109920.0 -41400.0 -1.61 115000.0 -39800.0 -1.49 -2.1936 -0.9993 1202102 Maybridge4_003148 COc1ccc(cc1OC)C2SC(=S)NC(=C2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P03 compound treatment 156160.0 4800.0 0.19 139760.0 -15100.0 -0.56 -0.2679 -0.4503 3178255 Maybridge4_003149 O=C(NC(=S)N1CCCCC1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P04 compound treatment 84600.0 -66800.0 -2.59 57680.0 -97100.0 -3.65 -4.4095 -0.986 3178256 Maybridge4_003150 Cc1cc(Sc2ccc(Cl)cc2)nc(n1)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P05 compound treatment 141560.0 -9800.0 -0.38 138560.0 -16300.0 -0.61 -0.7003 -0.9741 3064323 Maybridge4_003151 CCOC(=O)NC(=S)Nc1ccc(F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P06 compound treatment 146040.0 -5320.0 -0.21 153800.0 -1010.0 -0.04 -0.1729 -0.8235 1496124 Maybridge4_003152 Nc1nc(Cc2ccc(F)cc2F)no1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P07 compound treatment 150720.0 -643.0 -0.02 143840.0 -11000.0 -0.41 -0.3089 -0.7485 1646965 Maybridge4_003153 Oc1cc(O)n(Cc2ccco2)c(=S)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P08 compound treatment 127160.0 -24200.0 -0.94 121120.0 -33700.0 -1.26 -1.5582 -0.9893 3178257 Maybridge4_003154 COc1cc(NC(=O)C(Sc2nc(C)cc(C)c2C#N)c3ccccc3)c(OC)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P09 compound treatment 154560.0 3200.0 0.12 119440.0 -35400.0 -1.33 -0.8511 -0.6382 1555108 Maybridge4_003155 Sc1nc2ccccc2c(=O)n1CCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P10 compound treatment 139160.0 -12200.0 -0.47 125600.0 -29200.0 -1.1 -1.1101 -0.9295 1688911 Maybridge4_003156 CN(C(=O)N(C)C(=O)c1ccccc1)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P11 compound treatment 137080.0 -14300.0 -0.55 136320.0 -18500.0 -0.69 -0.8827 -0.9938 1186033 Maybridge4_003157 CCNC(=S)Nc1ccc(NC(=O)c2ccccc2O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P12 compound treatment 148640.0 -2720.0 -0.11 136600.0 -18200.0 -0.68 -0.5581 -0.8068 3064360 Maybridge4_003158 CN(C)/C=N/c1nonc1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P13 compound treatment 122400.0 -29000.0 -1.12 109960.0 -44900.0 -1.68 -1.985 -0.9807 3178258 Maybridge4_003159 COc1ccccc1/C=C(\C#N)/c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P14 compound treatment 146000.0 -5360.0 -0.21 136280.0 -18500.0 -0.7 -0.639 -0.8801 1641024 Maybridge4_003160 CC(C)NC(=O)Oc1noc2ccc(Cl)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P15 compound treatment 131720.0 -19600.0 -0.76 135320.0 -19500.0 -0.73 -1.0563 -0.9998 3178259 Maybridge4_003161 CS/C(=N\c1c(C)cccc1C)/N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P16 compound treatment 95120.0 -56200.0 -2.18 101360.0 -53500.0 -2.01 -2.9617 -0.9991 1687023 Maybridge4_003162 CC(C)(C)C(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P17 compound treatment 154200.0 2840.0 0.11 141320.0 -13500.0 -0.51 -0.2803 -0.5408 3064362 Maybridge4_003163 Cc1nc(S)nc(O)c1Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P18 compound treatment 84560.0 -66800.0 -2.59 53680.0 -101000.0 -3.8 -4.5168 -0.9827 1159384 Maybridge4_003164 COC(=O)c1c(NC(=O)NCc2ccccc2)onc1c3c(Cl)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P19 compound treatment 137640.0 -13700.0 -0.53 126160.0 -28700.0 -1.08 -1.1369 -0.9474 1135236 Maybridge4_003165 Clc1ccc(cc1)C(=O)Oc2ccccc2OCC(=O)NCc3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P20 compound treatment 136800.0 -14600.0 -0.57 129600.0 -25200.0 -0.95 -1.0687 -0.9696 3178260 Maybridge4_003166 CSc1nc(NC(=O)NS(=O)(=O)Cc2ccc(Cl)cc2Cl)nc(n1)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P21 compound treatment 134200.0 -17200.0 -0.67 142080.0 -12700.0 -0.48 -0.8088 -0.9868 1287410 Maybridge4_003167 CSc1nc2ccccc2c(=O)n1c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P22 compound treatment 140200.0 -11200.0 -0.43 137800.0 -17000.0 -0.64 -0.7578 -0.9821 3178261 Maybridge4_003168 COC(=O)c1ccc(nc1)C(=O)Nc2ccc(cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P23 mock treatment 146400.0 -4960.0 -0.19 156320.0 1510.0 0.06 -0.0962 -0.4793 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2057 P24 mock treatment 138120.0 -13200.0 -0.51 127600.0 -27200.0 -1.02 -1.0855 -0.9495 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A01 compound treatment 43200.0 -81600.0 -3.17 72400.0 -50200.0 -1.88 -3.5722 -0.9692 3064365 Maybridge4_003169 Clc1ccccc1CN2C(=O)CNC2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A02 compound treatment 21200.0 -104000.0 -4.02 88440.0 -34200.0 -1.28 -3.7501 -0.8885 3178262 Maybridge4_003170 Cc1cc(SCC(=O)NN)c(C)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A03 compound treatment 77800.0 -47000.0 -1.82 100440.0 -22200.0 -0.83 -1.8787 -0.9368 1123055 Maybridge4_003171 Clc1ccccc1OCCN2C(=O)CNC2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A04 compound treatment 106920.0 -17900.0 -0.69 97680.0 -24900.0 -0.94 -1.1531 -0.9893 3178263 Maybridge4_003172 CC(=O)N1c2ccccc2C=Cc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A05 compound treatment 5600.0 -119000.0 -4.63 7960.0 -115000.0 -4.3 -6.3139 -0.9993 3178264 Maybridge4_003173 COc1nc(NC(=O)NS(=O)(=O)Nc2cccc3cccnc23)nc(OC)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A06 compound treatment 30120.0 -94700.0 -3.67 93440.0 -29200.0 -1.09 -3.3727 -0.8796 1697760 Maybridge4_003174 S=C(NC1CC2CC1C=C2)Nc3ccc4[nH]ccc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A07 compound treatment 36560.0 -88300.0 -3.42 93560.0 -29100.0 -1.09 -3.1928 -0.8883 3064405 Maybridge4_003175 CNc1nc2c(Cl)cc(Cl)cc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A08 compound treatment 4720.0 -120000.0 -4.66 8000.0 -115000.0 -4.3 -6.337 -0.9992 3064407 Maybridge4_003176 CC(C)OC(=S)Nc1cccc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A09 compound treatment 121000.0 -3830.0 -0.15 119560.0 -3050.0 -0.11 -0.1861 -0.9917 3178265 Maybridge4_003177 CCN(C(=O)c1cnccc1C(F)(F)F)c2c(C)cccc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A10 compound treatment 124280.0 -550.0 -0.02 131120.0 8510.0 0.32 0.2107 0.6584 1316937 Maybridge4_003178 Cc1ccc(C)c(COc2ccc(C)nc2NC(=S)NCc3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A11 compound treatment 140760.0 15900.0 0.62 132760.0 10100.0 0.38 0.7064 0.9729 3064408 Maybridge4_003179 CC1(C)ONC(=O)N(C1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A12 compound treatment 10400.0 -114000.0 -4.44 38360.0 -84300.0 -3.16 -5.3755 -0.9862 1490878 Maybridge4_003180 COc1ccccc1C2CCN(CC2)C(=O)c3cccnc3Sc4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A13 compound treatment 132760.0 7930.0 0.31 114640.0 -7970.0 -0.3 0.006 0.0139 3064412 Maybridge4_003181 FC(F)(F)c1cccc(c1)n2c(noc2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A14 compound treatment 6000.0 -119000.0 -4.61 7360.0 -115000.0 -4.33 -6.3189 -0.9995 1158023 Maybridge4_003182 Sc1nnc(CSCc2cccc3ccccc23)n1C4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A15 compound treatment 7880.0 -117000.0 -4.54 12480.0 -110000.0 -4.13 -6.1314 -0.9989 3064413 Maybridge4_003183 Brc1ccc(cc1)C(=O)CSc2nc(c3cccs3)c(C#N)c(=O)[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A16 compound treatment 116320.0 -8510.0 -0.33 121520.0 -1090.0 -0.04 -0.2625 -0.7889 1059941 Maybridge4_003184 OC(=O)c1cc2cc(Cl)ccc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A17 compound treatment 4760.0 -120000.0 -4.66 7440.0 -115000.0 -4.32 -6.3508 -0.9993 3178266 Maybridge4_003185 Cc1cc(C)cc(Sc2ccc3nnc(c4ccccc4)n3n2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A18 compound treatment 4600.0 -120000.0 -4.66 6200.0 -116000.0 -4.37 -6.3881 -0.9995 3178267 Maybridge4_003186 CC(C)c1ccc(/C=C/2\CSc3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A19 compound treatment 119640.0 -5190.0 -0.2 131160.0 8550.0 0.32 0.0844 0.223 3064415 Maybridge4_003187 Cc1cc(Cc2ccc(Cl)cc2)c(=O)[nH]n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A20 compound treatment 74920.0 -49900.0 -1.94 115800.0 -6810.0 -0.26 -1.5501 -0.7936 3178268 Maybridge4_003188 O=C(/C=C\1/Nc2ccccc2OC1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A21 compound treatment 133520.0 8690.0 0.34 116200.0 -6410.0 -0.24 0.0682 0.1647 3064418 Maybridge4_003189 CCOC(=O)CSc1nc2cccnc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A22 compound treatment 45280.0 -79600.0 -3.09 45400.0 -77200.0 -2.9 -4.2317 -0.9995 3178269 Maybridge4_003190 COc1ccc(cc1)C2=Nc3ccccc3SC(C2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A23 mock treatment 144080.0 19300.0 0.75 116400.0 -6210.0 -0.23 0.3633 0.4643 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 A24 mock treatment 136520.0 11700.0 0.45 119600.0 -3010.0 -0.11 0.2408 0.5151 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B01 compound treatment 108560.0 -16300.0 -0.63 133920.0 11300.0 0.42 -0.1463 -0.1923 1225177 Maybridge4_003191 CCOC(=O)c1c(C)c(=O)oc2n(nc(O)c12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B02 compound treatment 12560.0 -112000.0 -4.36 22880.0 -99700.0 -3.74 -5.727 -0.9971 1739696 Maybridge4_003192 O=C1N(Cc2ccccc2)S(=O)(=O)c3ccccc3S(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B03 compound treatment 134680.0 9850.0 0.38 147000.0 24400.0 0.92 0.9175 0.925 3064449 Maybridge4_003193 CC(=O)OC[C@H]1O[C@@H](NC(=O)N)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B04 compound treatment 14600.0 -110000.0 -4.28 61160.0 -61500.0 -2.31 -4.6551 -0.958 2101805 Maybridge4_003194 CCC(=O)NC(Nc1ccc(O)cc1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B05 compound treatment 146480.0 21700.0 0.84 177120.0 54500.0 2.05 2.0406 0.9227 1443369 Maybridge4_003195 CCc1ccc2oc3nc(N)c(C#N)cc3c(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B06 compound treatment 139360.0 14500.0 0.56 153440.0 30800.0 1.16 1.2168 0.9454 1585673 Maybridge4_003196 CCOC(=O)CCc1ccc(OCc2ccccc2)c(I)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B07 compound treatment 108840.0 -16000.0 -0.62 164240.0 41600.0 1.56 0.6661 0.3962 3064452 Maybridge4_003197 CC(=O)OC[C@H]1OC[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@H]1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B08 compound treatment 16160.0 -109000.0 -4.22 86600.0 -36000.0 -1.35 -3.9372 -0.8892 3178366 Maybridge4_003198 CC1(C)c2ccccc2N3CC(=O)NC31/C=C/c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B09 compound treatment 117560.0 -7270.0 -0.28 138400.0 15800.0 0.59 0.2195 0.3345 1005564 Maybridge4_003199 CC(=O)Nc1ccc(cc1)c2ccc(NC(=O)C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B10 compound treatment 67800.0 -57000.0 -2.21 114680.0 -7930.0 -0.3 -1.7752 -0.7951 3178367 Maybridge4_003200 Cc1nn(c(O)c1Cc2c(Cl)cccc2Cl)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B11 compound treatment 7960.0 -117000.0 -4.53 10360.0 -112000.0 -4.21 -6.1855 -0.9993 1167085 Maybridge4_003201 COc1ccc(CC2CCc3ncc(C)cc3C2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B12 compound treatment 111440.0 -13400.0 -0.52 115120.0 -7490.0 -0.28 -0.5662 -0.9584 3178368 Maybridge4_003202 N/N=C(/Cn1nnc(n1)N2CCCCC2)\c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B13 compound treatment 142280.0 17500.0 0.68 130680.0 8070.0 0.3 0.6929 0.9342 3064453 Maybridge4_003203 S=c1sc2ccccc2n1CCn3c(=S)sc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B14 compound treatment 128640.0 3810.0 0.15 110240.0 -12400.0 -0.46 -0.2238 -0.4593 1238987 Maybridge4_003204 CCCc1c(C)nc(SCC(=O)C(C)(C)C)nc1OC(=O)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B15 compound treatment 10960.0 -114000.0 -4.42 35040.0 -87600.0 -3.29 -5.4482 -0.9894 3178369 Maybridge4_003205 CC1CN=C(S1)N(CCc2ccccc2)C(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B16 compound treatment 123560.0 -1270.0 -0.05 147960.0 25300.0 0.95 0.6379 0.6696 1004236 Maybridge4_003206 Cc1ccccc1NC(=N)NC(=N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B17 compound treatment 129160.0 4330.0 0.17 154960.0 32300.0 1.21 0.9773 0.7974 1381247 Maybridge4_003207 Sc1nnc(CCCc2nnc(S)o2)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B18 compound treatment 43800.0 -81000.0 -3.14 81480.0 -41100.0 -1.54 -3.3147 -0.9464 1184925 Maybridge4_003208 CN(C)C(=O)Oc1nc(SCC(=O)c2ccc(Cl)cc2)nc(C)c1CC(=C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B19 compound treatment 6000.0 -119000.0 -4.61 8960.0 -114000.0 -4.27 -6.2764 -0.9992 3064457 Maybridge4_003209 COc1ccccc1C2CCN(CCCOc3ccc(Cl)cc3)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B20 compound treatment 120760.0 -4070.0 -0.16 150200.0 27600.0 1.04 0.6205 0.5924 3178370 Maybridge4_003210 CCNC(=S)NCC1CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B21 compound treatment 50760.0 -74100.0 -2.87 95640.0 -27000.0 -1.01 -2.748 -0.9019 1489027 Maybridge4_003211 Oc1c(Cl)c(=O)n(Cc2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B22 compound treatment 49280.0 -75600.0 -2.93 88320.0 -34300.0 -1.29 -2.9829 -0.9317 1250091 Maybridge4_003212 O=C(Nc1ccc(cc1)S(=O)(=O)NC2(CC3CC4CC(C3)C2)C4)C5CC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B23 mock treatment 140480.0 15700.0 0.61 150600.0 28000.0 1.05 1.1721 0.9661 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 B24 mock treatment 147440.0 22600.0 0.88 133520.0 10900.0 0.41 0.9098 0.9398 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C01 compound treatment 30600.0 -94200.0 -3.66 39320.0 -83300.0 -3.13 -4.7958 -0.997 3064501 Maybridge4_003213 O=C(Nc1ccccc1)Nc2ccc3nnsc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C02 compound treatment 5520.0 -119000.0 -4.63 7320.0 -115000.0 -4.33 -6.3331 -0.9994 1507422 Maybridge4_003214 CC(C)(C)c1ccc(OCC(=O)n2ncc(C#N)c2N)c(c1)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C03 compound treatment 80720.0 -44100.0 -1.71 121360.0 -1250.0 -0.05 -1.2434 -0.7263 1402640 Maybridge4_003215 COc1ccc(OCCN2C(=O)CNC2=S)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C04 compound treatment 92840.0 -32000.0 -1.24 130240.0 7630.0 0.29 -0.6752 -0.5301 1499674 Maybridge4_003216 Cc1ccc2N(CCCc2c1)C(=O)CC(=O)N3CCCc4cc(C)ccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C05 compound treatment 8200.0 -117000.0 -4.53 10640.0 -112000.0 -4.2 -6.1715 -0.9993 3064504 Maybridge4_003217 CC(C)c1ccc(NC(=S)Sc2ccc(F)cc2F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C06 compound treatment 95520.0 -29300.0 -1.14 119160.0 -3450.0 -0.13 -0.8958 -0.7826 1213648 Maybridge4_003218 Cc1ccc(CC(=S)N2CCOCC2)cn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C07 compound treatment 31720.0 -93100.0 -3.61 69480.0 -53100.0 -1.99 -3.9646 -0.9608 3178371 Maybridge4_003219 CCN(C(=O)c1cnccc1C(F)(F)F)c2nc3cc(Cl)ccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C08 compound treatment 101960.0 -22900.0 -0.89 112600.0 -10000.0 -0.38 -0.8932 -0.9269 1153252 Maybridge4_003220 COc1cc2cc(OCc3c(F)cccc3Cl)nc(C)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C09 compound treatment 114440.0 -10400.0 -0.4 143520.0 20900.0 0.78 0.2698 0.3058 3178372 Maybridge4_003221 CSc1cc(c(cn1)C(=O)Nc2c(C)cccc2C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C10 compound treatment 7800.0 -117000.0 -4.54 17080.0 -106000.0 -3.96 -6.0115 -0.9977 3064507 Maybridge4_003222 CCC/N=c/1\ssc(=O)n1CCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C11 compound treatment 134440.0 9610.0 0.37 140520.0 17900.0 0.67 0.7389 0.9614 3178373 Maybridge4_003223 COc1nccc(c1C(=O)NC(=O)Nc2c(C)cccc2C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C12 compound treatment 14720.0 -110000.0 -4.27 13080.0 -110000.0 -4.11 -5.9278 -0.9998 3064509 Maybridge4_003224 FC(F)(F)c1ccc(NC(=O)CSCc2cccc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C13 compound treatment 145400.0 20600.0 0.8 127600.0 4990.0 0.19 0.6967 0.8499 1304317 Maybridge4_003225 Clc1cccc(c1)c2noc(=O)n2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C14 compound treatment 79880.0 -45000.0 -1.74 117640.0 -4970.0 -0.19 -1.3652 -0.7783 1154699 Maybridge4_003226 CC(C)COC(=O)c1cn(C2CCCCC2)c3ccccc3c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C15 compound treatment 82120.0 -42700.0 -1.66 109800.0 -12800.0 -0.48 -1.5118 -0.8762 1407275 Maybridge4_003227 COC(=O)C1c2ccccc2Oc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C16 compound treatment 103000.0 -21800.0 -0.85 130960.0 8350.0 0.31 -0.3774 -0.4179 1661086 Maybridge4_003228 COc1ccc(CC2C(=O)OC(C)(C)OC2=O)c(Cl)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C17 compound treatment 94760.0 -30100.0 -1.17 129840.0 7230.0 0.27 -0.6332 -0.5286 3178374 Maybridge4_003229 CC1=C(Sc2ccccc2N1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C18 compound treatment 9600.0 -115000.0 -4.47 45760.0 -76900.0 -2.88 -5.201 -0.9775 3064548 Maybridge4_003230 O=C1/C(=C/c2c[nH]c3ccccc23)/CSc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C19 compound treatment 122320.0 -2510.0 -0.1 139120.0 16500.0 0.62 0.3692 0.5887 3178375 Maybridge4_003231 Cc1cc(Cc2cccs2)c(=O)[nH]n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C20 compound treatment 7720.0 -117000.0 -4.54 10160.0 -112000.0 -4.22 -6.1974 -0.9993 1550561 Maybridge4_003232 OC(COc1ccc(F)cc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C21 compound treatment 141200.0 16400.0 0.64 142000.0 19400.0 0.73 0.9636 0.9977 1029711 Maybridge4_003233 CCOC(=O)c1cc(=O)c2ccc(OCc3ccccc3)cc2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C22 compound treatment 7120.0 -118000.0 -4.57 8800.0 -114000.0 -4.27 -6.2499 -0.9994 3178376 Maybridge4_003234 Oc1ccc(cc1)C2CC(=Nc3ccccc3S2)c4ccccc4O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C23 mock treatment 118000.0 -6830.0 -0.27 127000.0 4390.0 0.16 -0.0709 -0.2274 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 C24 mock treatment 144600.0 19800.0 0.77 129560.0 6950.0 0.26 0.7268 0.8971 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D01 compound treatment 113080.0 -11800.0 -0.46 124400.0 1790.0 0.07 -0.2749 -0.5966 1653141 Maybridge4_003235 Nc1cc(=O)[nH]c(=O)n1c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D02 compound treatment 125560.0 730.0 0.03 150680.0 28100.0 1.05 0.7649 0.7259 3178377 Maybridge4_003236 CNS(=O)(=O)c1ccc(cc1S(=O)c2ccccc2C(=O)O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D03 compound treatment 94840.0 -30000.0 -1.16 111960.0 -10700.0 -0.4 -1.1055 -0.8985 1915933 Maybridge4_003237 COC(=O)Nc1nc2cc(ccc2[nH]1)c3n[nH]c(=O)c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D04 compound treatment 141200.0 16400.0 0.64 154200.0 31600.0 1.19 1.2874 0.9572 1252966 Maybridge4_003238 Oc1c(c2ccccc2)c(=O)[nH]c3ccc(F)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D05 compound treatment 129480.0 4650.0 0.18 139880.0 17300.0 0.65 0.5858 0.8708 3178378 Maybridge4_003239 Brc1ccc(cc1)C(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D06 compound treatment 145320.0 20500.0 0.8 154920.0 32300.0 1.21 1.4196 0.979 3064551 Maybridge4_003240 CCN1C(=O)N(CC)C(=O)C(=Cc2c(O)n(CC)c(=O)n(CC)c2=O)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D07 compound treatment 128040.0 3210.0 0.12 152040.0 29400.0 1.1 0.869 0.7819 3178379 Maybridge4_003241 CC(=O)O[C@@H]1CO[C@@H]([C@@H](OC(=O)C)[C@@H]1OC(=O)C)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D08 compound treatment 72360.0 -52500.0 -2.04 108040.0 -14600.0 -0.55 -1.8263 -0.8664 3178380 Maybridge4_003242 CC1(C)c2ccccc2N3CC(=O)NC31/C=C/c4ccc(cc4)N5CCOCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D09 compound treatment 8840.0 -116000.0 -4.5 12120.0 -110000.0 -4.15 -6.1146 -0.9992 1190502 Maybridge4_003243 Clc1ccc2n(CN3CCCCC3)c4ccc(Cl)cc4c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D10 compound treatment 58560.0 -66300.0 -2.57 107680.0 -14900.0 -0.56 -2.2145 -0.8415 3064581 Maybridge4_003244 CNC(=S)Nc1cc(Cl)cc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D11 compound treatment 10600.0 -114000.0 -4.43 53960.0 -68700.0 -2.58 -4.956 -0.9667 1208488 Maybridge4_003245 OC(=O)CCC1CCCCCCCCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D12 compound treatment 97880.0 -27000.0 -1.05 114600.0 -8010.0 -0.3 -0.952 -0.875 3064582 Maybridge4_003246 O/N=C(/Cn1nnc(n1)N2CCCC2)\c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D13 compound treatment 143680.0 18900.0 0.73 153240.0 30600.0 1.15 1.33 0.9762 3064584 Maybridge4_003247 C([n+]1ccccc1)[n+]2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D14 compound treatment 76480.0 -48400.0 -1.88 107280.0 -15300.0 -0.58 -1.7334 -0.8834 3178381 Maybridge4_003248 Cc1nc(SCC(=O)C(C)(C)C)nc(O)c1Cc2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D15 compound treatment 14880.0 -110000.0 -4.27 38320.0 -84300.0 -3.16 -5.2536 -0.9892 3178382 Maybridge4_003249 CC(N(C(=O)Nc1ccc(Cl)cc1)C2=NCC(C)S2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D16 compound treatment 41640.0 -83200.0 -3.23 42840.0 -79800.0 -2.99 -4.3995 -0.9993 3064586 Maybridge4_003250 CC(C)(C)c1cs/c(=N\c2ccc(F)cc2F)/o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D17 compound treatment 62520.0 -62300.0 -2.42 101080.0 -21500.0 -0.81 -2.281 -0.8948 3178383 Maybridge4_003251 C(CCc1nnc(SCc2ccccc2)o1)Cc3nnc(SCc4ccccc4)o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D18 compound treatment 31640.0 -93200.0 -3.62 62040.0 -60600.0 -2.27 -4.1643 -0.975 3064589 Maybridge4_003252 FC(F)(F)c1ccc(Cl)c(Nc2ncnc(n2)n3cccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D19 compound treatment 136880.0 12100.0 0.47 150520.0 27900.0 1.05 1.0712 0.9339 1521138 Maybridge4_003253 COc1ccc(CCNC(=O)C2CCCCC2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D20 compound treatment 123920.0 -910.0 -0.04 144360.0 21700.0 0.82 0.5522 0.6759 2078178 Maybridge4_003254 CC(C)[n+]1c(C)csc1Nc2ccc(F)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D21 compound treatment 129120.0 4290.0 0.17 150760.0 28100.0 1.06 0.8647 0.8085 1308049 Maybridge4_003255 O=c1cc(NCc2ccccc2)[nH]nc1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D22 compound treatment 21160.0 -104000.0 -4.02 57840.0 -64800.0 -2.43 -4.5633 -0.9709 3178478 Maybridge4_003256 CCCC1=NNC(=O)C1Cc2c(Cl)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D23 mock treatment 120600.0 -4230.0 -0.16 132240.0 9630.0 0.36 0.1394 0.3514 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 D24 mock treatment 105960.0 -18900.0 -0.73 127800.0 5190.0 0.19 -0.38 -0.5016 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E01 compound treatment 41240.0 -83600.0 -3.24 55760.0 -66900.0 -2.51 -4.0676 -0.992 3064592 Maybridge4_003257 CSC1=NCC(=O)N1Cc2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E02 compound treatment 122280.0 -2550.0 -0.1 138520.0 15900.0 0.6 0.3522 0.582 1522772 Maybridge4_003258 CCCCc1cc(C)c2ncc(C(=O)O)c(O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E03 compound treatment 113360.0 -11500.0 -0.45 119360.0 -3250.0 -0.12 -0.401 -0.869 1340715 Maybridge4_003259 CC(C)NC(=O)N(Cc1cccs1)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E04 compound treatment 65000.0 -59800.0 -2.32 75040.0 -47600.0 -1.79 -2.904 -0.9916 1280280 Maybridge4_003260 Oc1c(c2ccccc2)c(=O)n3c4ccccc4c5cccc1c53 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E05 compound treatment 144160.0 19300.0 0.75 146520.0 23900.0 0.9 1.1648 0.996 3178479 Maybridge4_003261 COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc2nc(C)c3CS(=O)(=O)CCc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E06 compound treatment 135360.0 10500.0 0.41 143840.0 21200.0 0.8 0.8523 0.9519 1428973 Maybridge4_003262 COC(=O)C1=C(C)NC(=O)CC1c2ccccc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E07 compound treatment 126280.0 1450.0 0.06 142000.0 19400.0 0.73 0.5543 0.7595 3178480 Maybridge4_003263 CSc1nc(nc(N)c1C#N)c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E08 compound treatment 121520.0 -3310.0 -0.13 134000.0 11400.0 0.43 0.2114 0.4737 1476870 Maybridge4_003264 COc1ccc2n(C3CC3)c(C)c(C(=O)ON4C(=O)CCC4=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E09 compound treatment 117280.0 -7550.0 -0.29 127000.0 4390.0 0.16 -0.0907 -0.2699 3178481 Maybridge4_003265 Cc1cccc(C)c1NC(=O)c2cnc(NC3CCCCC3)cc2C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E10 compound treatment 129480.0 4650.0 0.18 130560.0 7950.0 0.3 0.3385 0.971 3063905 Maybridge4_003266 FC(F)(F)c1cc(Cl)c2ncc(nc2c1)c3ccc(Br)s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E11 compound treatment 121960.0 -2870.0 -0.11 126760.0 4150.0 0.16 0.0313 0.1637 3178482 Maybridge4_003267 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/c2ccsc2)/C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E12 compound treatment 54840.0 -70000.0 -2.72 84720.0 -37900.0 -1.42 -2.9259 -0.9545 1329285 Maybridge4_003268 CC(C)C1CCC(C)CC1NCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E13 compound treatment 144040.0 19200.0 0.75 142960.0 20300.0 0.76 1.067 0.9999 3063910 Maybridge4_003269 COc1ccccc1c2nn(c3cccc(n3)C(F)(F)F)c(=O)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E14 compound treatment 127240.0 2410.0 0.09 134880.0 12300.0 0.46 0.3917 0.8337 1482860 Maybridge4_003270 COc1ccc(Oc2ncccc2NC(=O)c3ccc(OC)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E15 compound treatment 113840.0 -11000.0 -0.43 116120.0 -6490.0 -0.24 -0.4738 -0.9648 1317058 Maybridge4_003271 COc1ccc(CNc2nc(c3cccs3)c(C#N)c(=O)n2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E16 compound treatment 123880.0 -950.0 -0.04 133600.0 11000.0 0.41 0.2655 0.6413 3063941 Maybridge4_003272 Cc1n[nH]c(=S)n1/N=C\c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E17 compound treatment 122720.0 -2110.0 -0.08 116680.0 -5930.0 -0.22 -0.2153 -0.9077 1597311 Maybridge4_003273 CCOC(CNc1ccc2nnc(c3ccccc3)n2n1)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E18 compound treatment 9720.0 -115000.0 -4.47 11080.0 -112000.0 -4.19 -6.1181 -0.9995 3063945 Maybridge4_003274 O=C1/C(=C\c2c[nH]c3ccccc23)/C(Oc4ccccc14)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E19 compound treatment 127560.0 2730.0 0.11 123240.0 628.0 0.02 0.0916 0.8437 3178483 Maybridge4_003275 Cc1cc(Cc2ccc(cc2)C(F)(F)F)c(=O)[nH]n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E20 compound treatment 124840.0 10.0 0.0 157160.0 34500.0 1.3 0.9171 0.7073 1460994 Maybridge4_003276 CN(C)CCC(O)(CCc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E21 compound treatment 13440.0 -111000.0 -4.32 17520.0 -105000.0 -3.94 -5.8451 -0.999 3063949 Maybridge4_003277 CN(C)/C=N/c1nnc(Sc2ccnc3cc(Cl)ccc23)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E22 compound treatment 27840.0 -97000.0 -3.76 63400.0 -59200.0 -2.22 -4.2324 -0.9684 1708827 Maybridge4_003278 CCOC(=O)COc1ccc(cc1)C2=Nc3ccccc3NC(C2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E23 mock treatment 129640.0 4810.0 0.19 130400.0 7790.0 0.29 0.3386 0.9765 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 E24 mock treatment 107040.0 -17800.0 -0.69 127480.0 4870.0 0.18 -0.3589 -0.5027 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F01 compound treatment 60840.0 -64000.0 -2.48 76360.0 -46300.0 -1.74 -2.9831 -0.9847 3063951 Maybridge4_003279 Brc1ccc(cc1)C(=O)C2C(=O)OC(=CC2=O)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F02 compound treatment 109840.0 -15000.0 -0.58 129120.0 6510.0 0.24 -0.2386 -0.3782 1535413 Maybridge4_003280 CN1CCN(CCN2C(=O)c3ccccc3Sc4cc(Cl)ccc4S2(=O)=O)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F03 compound treatment 114520.0 -10300.0 -0.4 139280.0 16700.0 0.63 0.1595 0.2148 1134402 Maybridge4_003281 O=S(=O)(N(CCC#N)C1CCCCC1)c2cccc3nsnc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F04 compound treatment 14640.0 -110000.0 -4.28 20040.0 -103000.0 -3.85 -5.7453 -0.9986 3178484 Maybridge4_003282 Cc1ccccc1/C=C/c2c[nH]c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F05 compound treatment 140480.0 15700.0 0.61 147600.0 25000.0 0.94 1.0925 0.9779 3063955 Maybridge4_003283 OC(=O)c1ccc(cc1C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F06 compound treatment 152160.0 27300.0 1.06 150680.0 28100.0 1.05 1.4947 1.0 1062519 Maybridge4_003284 O=C(C1CCCCC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F07 compound treatment 122680.0 -2150.0 -0.08 141040.0 18400.0 0.69 0.4301 0.6173 3178485 Maybridge4_003285 O=C(OC[C@H]1O[C@@H](C#N)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F08 compound treatment 9880.0 -115000.0 -4.46 11440.0 -111000.0 -4.17 -6.1042 -0.9994 1658235 Maybridge4_003286 CC1(C)c2ccccc2N(CCC(=O)N)C31Oc4ccc5ccccc5c4C=C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F09 compound treatment 9800.0 -115000.0 -4.46 11640.0 -111000.0 -4.16 -6.101 -0.9994 1416171 Maybridge4_003287 OC(CN1CCNCC1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F10 compound treatment 147800.0 23000.0 0.89 143240.0 20600.0 0.77 1.1776 0.9975 1438412 Maybridge4_003288 O=C(Cn1nnc(n1)N2CCOCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F11 compound treatment 137960.0 13100.0 0.51 145040.0 22400.0 0.84 0.9554 0.9711 3178486 Maybridge4_003289 COc1cc(COC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)cc(OC)c1.C1CCC(CC1)NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F12 compound treatment 148120.0 23300.0 0.9 150560.0 27900.0 1.05 1.3807 0.9972 1614817 Maybridge4_003290 COc1ccc(CCNC(=S)NC2CC2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F13 compound treatment 58280.0 -66600.0 -2.58 56360.0 -66300.0 -2.49 -3.5841 -0.9998 3178487 Maybridge4_003291 CCN1/C(=C\C(=S)Nc2ccccc2)/Sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F14 compound treatment 138800.0 14000.0 0.54 146760.0 24100.0 0.91 1.0241 0.9698 1593331 Maybridge4_003292 CC(C)(C)C(=O)Cn1nnc(n1)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F15 compound treatment 109080.0 -15800.0 -0.61 123920.0 1310.0 0.05 -0.3974 -0.6482 3063998 Maybridge4_003293 CC1=[N+](C)c2cc(ccc2C1(C)C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F16 compound treatment 12040.0 -113000.0 -4.38 12920.0 -110000.0 -4.12 -6.0056 -0.9995 3178488 Maybridge4_003294 Fc1ccc(NC(=S)Nc2cc(ccc2N3CCCC3)C(F)(F)F)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F17 compound treatment 122240.0 -2590.0 -0.1 144320.0 21700.0 0.81 0.505 0.6152 1142281 Maybridge4_003295 CN1C(=C(C(NC1=O)c2ccccc2)C(=O)OCc3ccccc3)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F18 compound treatment 128200.0 3370.0 0.13 130120.0 7510.0 0.28 0.2917 0.9391 1704243 Maybridge4_003296 COCc1cc(O)n2nc(Nc3cc(Cl)ccc3C)nc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F19 compound treatment 147880.0 23100.0 0.89 145080.0 22500.0 0.84 1.2287 0.9996 1313602 Maybridge4_003297 O=c1cc(NCc2ccccc2)n(c3ccccc3)c(=O)n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F20 compound treatment 134560.0 9730.0 0.38 145560.0 22900.0 0.86 0.876 0.9315 1473392 Maybridge4_003298 CCN(CC)C(=O)Sc1nc2ccccc2c(=O)n1CC3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F21 compound treatment 148400.0 23600.0 0.91 144920.0 22300.0 0.84 1.2387 0.999 1547311 Maybridge4_003299 OC(=O)C1(C2C3C14)C5C2CCC3C45C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F22 compound treatment 92840.0 -32000.0 -1.24 128080.0 5470.0 0.21 -0.7326 -0.5823 3064002 Maybridge4_003300 CCCc1cc(=O)oc2cc(OC(=O)/C=C/c3cccs3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F23 mock treatment 135840.0 11000.0 0.43 137120.0 14500.0 0.54 0.6871 0.9928 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 F24 mock treatment 109120.0 -15700.0 -0.61 135920.0 13300.0 0.5 -0.0779 -0.0988 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G01 compound treatment 69800.0 -55000.0 -2.14 67000.0 -55600.0 -2.09 -2.9857 -0.9999 1507436 Maybridge4_003301 Cc1cc(no1)N(Cc2cccc(Cl)c2Cl)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G02 compound treatment 118840.0 -5990.0 -0.23 123960.0 1350.0 0.05 -0.1286 -0.5406 1593004 Maybridge4_003302 O=c1ccc(n[nH]1)c2ccncc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G03 compound treatment 114640.0 -10200.0 -0.4 112400.0 -10200.0 -0.38 -0.5506 -0.9999 3178489 Maybridge4_003303 CSC1=N/C(=C\c2ccccc2Cl)/C(=O)N1N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G04 compound treatment 84960.0 -39900.0 -1.55 99800.0 -22800.0 -0.86 -1.6993 -0.9611 3178490 Maybridge4_003304 COc1ccc(C/N=C(\C)/c2c(O)c3ccccc3n(C)c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G05 compound treatment 132640.0 7810.0 0.3 137040.0 14400.0 0.54 0.5972 0.9624 3064042 Maybridge4_003305 CCN(C(=O)c1cnccc1C(F)(F)F)c2ccc(Cl)cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G06 compound treatment 77640.0 -47200.0 -1.83 95360.0 -27300.0 -1.02 -2.018 -0.9622 1261792 Maybridge4_003306 Cc1ccc(Oc2ncccc2NC(=O)C(=S)NCc3ccccc3)c4CCCc41 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G07 compound treatment 138600.0 13800.0 0.53 139320.0 16700.0 0.63 0.8212 0.9968 3064045 Maybridge4_003307 Cc1nc(c2nnc(o2)c3ccccc3)c(o1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G08 compound treatment 100680.0 -24200.0 -0.94 119520.0 -3090.0 -0.12 -0.7446 -0.7887 3178491 Maybridge4_003308 COc1ccc(cc1OC2CCCC2)C3CC(=O)NN3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G09 compound treatment 131400.0 6570.0 0.25 146920.0 24300.0 0.91 0.8253 0.8713 3064046 Maybridge4_003309 CNC(=O)NC(=O)c1cnccc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G10 compound treatment 134600.0 9770.0 0.38 144360.0 21700.0 0.82 0.8452 0.9392 1193128 Maybridge4_003310 Cc1c(OCc2ccc(Cl)cc2Cl)ccc3C(=O)CC(C)(C)Oc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G11 compound treatment 10200.0 -115000.0 -4.45 11240.0 -111000.0 -4.18 -6.1007 -0.9995 3064048 Maybridge4_003311 COC(=O)c1cnc(Oc2c(Cl)cc(N)cc2Cl)cc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G12 compound treatment 59440.0 -65400.0 -2.54 53600.0 -69000.0 -2.59 -3.6256 -0.9999 1126959 Maybridge4_003312 COc1ccccc1C2CCN(CC2)C(=O)CSCc3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G13 compound treatment 94760.0 -30100.0 -1.17 112320.0 -10300.0 -0.39 -1.0981 -0.8935 3064052 Maybridge4_003313 COc1cccc(OC)c1CN(C)C(=O)c2cnc(Oc3ccccc3)cc2C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G14 compound treatment 9600.0 -115000.0 -4.47 10840.0 -112000.0 -4.2 -6.1278 -0.9995 1245694 Maybridge4_003314 NNC(=O)Cn1c2ccccc2c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G15 compound treatment 156800.0 32000.0 1.24 138080.0 15500.0 0.58 1.2876 0.9402 3064053 Maybridge4_003315 CC1CC(=O)NN=C1c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G16 compound treatment 139800.0 15000.0 0.58 145960.0 23300.0 0.88 1.0303 0.9801 3178582 Maybridge4_003316 COc1cc(/C=N\n2cn[nH]c2=S)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G17 compound treatment 94360.0 -30500.0 -1.18 107760.0 -14900.0 -0.56 -1.2301 -0.9411 1565631 Maybridge4_003317 CSc1nc2cccc(F)c2c(=O)n1c3ccc(C)c(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G18 compound treatment 124120.0 -710.0 -0.03 124440.0 1830.0 0.07 0.029 0.3926 1496711 Maybridge4_003318 Cc1ccccc1NC(=O)COc2ccc3C(=O)CC(C)(C)Oc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G19 compound treatment 146480.0 21700.0 0.84 155440.0 32800.0 1.23 1.4652 0.9826 3178583 Maybridge4_003319 CCc1nc(S)[nH]c(=O)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G20 compound treatment 132840.0 8010.0 0.31 130400.0 7790.0 0.29 0.4264 0.9995 1520911 Maybridge4_003320 O=C1CC(Sc2ccccc2N1)c3coc4ccccc4c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G21 compound treatment 118080.0 -6750.0 -0.26 127200.0 4590.0 0.17 -0.0634 -0.2024 1387364 Maybridge4_003321 CC(=O)N1CCc2cc(NC(=S)Nc3ccccc3Cl)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G22 compound treatment 32680.0 -92200.0 -3.58 33120.0 -89500.0 -3.36 -4.9033 -0.9995 1175310 Maybridge4_003322 O=C(COc1ccc(cc1)C2=Nc3ccccc3NC(C2)c4ccccc4)Nc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G23 mock treatment 121640.0 -3190.0 -0.12 132280.0 9670.0 0.36 0.169 0.4409 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 G24 mock treatment 114160.0 -10700.0 -0.41 122280.0 -333.0 -0.01 -0.3016 -0.7281 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H01 compound treatment 127040.0 2210.0 0.09 114320.0 -8290.0 -0.31 -0.1594 -0.4939 3064847 Maybridge4_003323 N=C(NC(=S)Nc1ccccc1)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H02 compound treatment 125560.0 730.0 0.03 136240.0 13600.0 0.51 0.3817 0.7451 1265943 Maybridge4_003324 Oc1cc(c2ccc(F)cc2)n(c3ccccc3)c(=O)c1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H03 compound treatment 20760.0 -104000.0 -4.04 22280.0 -100000.0 -3.77 -5.518 -0.9994 1493327 Maybridge4_003325 CC(C)c1c(Br)c(=O)oc2c3CCCN4CCCc(cc12)c43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H04 compound treatment 144800.0 20000.0 0.77 149600.0 27000.0 1.01 1.2641 0.9913 1020946 Maybridge4_003326 NC(=O)NCCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H05 compound treatment 156560.0 31700.0 1.23 147360.0 24700.0 0.93 1.5273 0.9903 3064848 Maybridge4_003327 C/C(=N/O)/CC(c1ccccc1)c2c(O)c3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H06 compound treatment 139520.0 14700.0 0.57 152880.0 30300.0 1.14 1.2063 0.9491 1378346 Maybridge4_003328 Cn1c(=O)n(C)c2ncn(CC(O)COc3ccccc3)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H07 compound treatment 160440.0 35600.0 1.38 154520.0 31900.0 1.2 1.8238 0.9975 3064849 Maybridge4_003329 CO[C@@H]1O[C@H](COC(=O)c2ccccc2)[C@H](OC(=O)c3ccccc3)[C@H]1OC(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H08 compound treatment 79240.0 -45600.0 -1.77 98280.0 -24300.0 -0.91 -1.8966 -0.9527 1554777 Maybridge4_003330 CCn1c2C(=O)CCCc2c3cc(OCc4ccccc4)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H09 compound treatment 132360.0 7530.0 0.29 146320.0 23700.0 0.89 0.8358 0.8924 3064850 Maybridge4_003331 OC1=C(C(=O)c2ccccc12)c3ccc(I)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H10 compound treatment 148840.0 24000.0 0.93 135360.0 12700.0 0.48 0.997 0.952 3178584 Maybridge4_003332 FC(F)(F)c1cccc(c1)n2c(S)nnc2Cn3nnc(n3)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H11 compound treatment 12160.0 -113000.0 -4.37 12480.0 -110000.0 -4.13 -6.014 -0.9996 1668484 Maybridge4_003333 Fc1ccc(cc1)N(C(=O)C2(CC3CC4CC(C3)C2)C4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H12 compound treatment 142400.0 17600.0 0.68 146320.0 23700.0 0.89 1.1112 0.9913 3064851 Maybridge4_003334 COc1ccc(CCN/2C(=O)CS\C2=N/C3CC3)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H13 compound treatment 131040.0 6210.0 0.24 133600.0 11000.0 0.41 0.462 0.9673 1561039 Maybridge4_003335 O=c1[nH]c2ccccc2c(=O)n1CCSc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H14 compound treatment 9960.0 -115000.0 -4.46 9920.0 -113000.0 -4.23 -6.1423 -0.9997 3064852 Maybridge4_003336 CC/N=C(/Nc1ccc(cc1)C(C)(C)C)\SCC2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H15 compound treatment 16920.0 -108000.0 -4.19 17960.0 -105000.0 -3.93 -5.738 -0.9995 1155855 Maybridge4_003337 Oc1c(O)c(CN2CCCCC2)c3ccccc3c1CN4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H16 compound treatment 136040.0 11200.0 0.43 152880.0 30300.0 1.14 1.1108 0.9132 3064853 Maybridge4_003338 COC(=O)c1cccc(NC(=N)NC(=N)N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H17 compound treatment 147000.0 22200.0 0.86 153040.0 30400.0 1.14 1.4158 0.9902 3178585 Maybridge4_003339 Clc1ccc(cc1)S(=O)(=O)C2=CC34CCCC4(C2)C=C(C3)S(=O)(=O)c5ccc(Cl)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H18 compound treatment 144040.0 19200.0 0.75 167480.0 44900.0 1.68 1.7178 0.9328 3064854 Maybridge4_003340 CC(=C)CC1C(=NNC1=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H19 compound treatment 148920.0 24100.0 0.93 140160.0 17500.0 0.66 1.1266 0.9853 3178586 Maybridge4_003341 CC1(C)O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O1)n3cnc4c(N)ncnc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H20 compound treatment 102440.0 -22400.0 -0.87 99040.0 -23600.0 -0.88 -1.2399 -1.0 3064855 Maybridge4_003342 Clc1ccc(NC(=S)NCC2CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H21 compound treatment 132960.0 8130.0 0.32 128560.0 5950.0 0.22 0.3809 0.9857 1331091 Maybridge4_003343 CN(C)CCNc1cc(nc2ccccc12)c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H22 compound treatment 9560.0 -115000.0 -4.47 9360.0 -113000.0 -4.25 -6.1681 -0.9997 1734961 Maybridge4_003344 CCCc1c(Cc2c(F)cccc2Cl)c(=O)oc3cc(O)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H23 mock treatment 122760.0 -2070.0 -0.08 144120.0 21500.0 0.81 0.514 0.6336 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 H24 mock treatment 114280.0 -10600.0 -0.41 116000.0 -6610.0 -0.25 -0.4649 -0.9713 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I01 compound treatment 99720.0 -25100.0 -0.97 83000.0 -39600.0 -1.49 -1.7402 -0.979 3178587 Maybridge4_003345 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I02 compound treatment 71080.0 -53800.0 -2.09 92960.0 -29700.0 -1.11 -2.2616 -0.9567 1626253 Maybridge4_003346 CSc1c(C#N)c(N)nc2sc(C(=O)c3ccc(Cl)c(Cl)c3)c(N)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I03 compound treatment 145800.0 21000.0 0.81 117280.0 -5330.0 -0.2 0.4338 0.5177 1244996 Maybridge4_003347 CCNC(=O)N(Cc1ccccc1)Cc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I04 compound treatment 133960.0 9130.0 0.35 140400.0 17800.0 0.67 0.7226 0.9561 1073759 Maybridge4_003348 CSc1ncc(Br)c(n1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I05 compound treatment 143760.0 18900.0 0.73 144720.0 22100.0 0.83 1.1061 0.9982 3178588 Maybridge4_003349 CC(C)(C)NC(=O)Nc1cnccc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I06 compound treatment 137600.0 12800.0 0.5 136320.0 13700.0 0.51 0.7141 0.9998 3064856 Maybridge4_003350 CCOC(=O)CC1=Nn2c(nnc2SC1)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I07 compound treatment 142080.0 17300.0 0.67 120440.0 -2170.0 -0.08 0.4156 0.6164 3178589 Maybridge4_003351 Cc1nc(C(=O)NCC(=O)c2ccc(Cl)cc2)c(o1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I08 compound treatment 145320.0 20500.0 0.8 127920.0 5310.0 0.2 0.703 0.8578 1403866 Maybridge4_003352 O=c1cc([nH]c(=O)[nH]1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I09 compound treatment 133880.0 9050.0 0.35 112320.0 -10300.0 -0.39 -0.0249 -0.0476 3178590 Maybridge4_003353 COc1ccc(CN(C)C(=O)c2cnc(OC)cc2C(F)(F)F)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I10 compound treatment 11240.0 -114000.0 -4.41 9920.0 -113000.0 -4.23 -6.1072 -0.9998 1529338 Maybridge4_003354 CCCCc1ccc(NC(=O)CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I11 compound treatment 136960.0 12100.0 0.47 131200.0 8590.0 0.32 0.5607 0.9829 3064857 Maybridge4_003355 CN(C(=O)c1cn(C)c(=O)cc1C(F)(F)F)c2ccc(Cl)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I12 compound treatment 145600.0 20800.0 0.81 136120.0 13500.0 0.51 0.9283 0.975 1141964 Maybridge4_003356 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3cccc4nonc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I13 compound treatment 156880.0 32100.0 1.24 135640.0 13000.0 0.49 1.2251 0.9168 3064858 Maybridge4_003357 CSc1nc(Nc2cccc(c2)C(F)(F)F)cc(c1C#N)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I14 compound treatment 101800.0 -23000.0 -0.89 99040.0 -23600.0 -0.88 -1.2574 -1.0 1260487 Maybridge4_003358 Cc1ccc(Sc2ncccc2NC(=O)c3cccc4ccccc34)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I15 compound treatment 130280.0 5450.0 0.21 112000.0 -10600.0 -0.4 -0.1321 -0.293 1269491 Maybridge4_003359 CCOC(=O)c1cnn2c1nc(Sc3cccc(OC)c3)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I16 compound treatment 136000.0 11200.0 0.43 113000.0 -9610.0 -0.36 0.0514 0.0911 1008109 Maybridge4_003360 S=C(Nc1ccccn1)Nc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I17 compound treatment 125520.0 690.0 0.03 119000.0 -3610.0 -0.14 -0.0769 -0.5567 3064859 Maybridge4_003361 O/N=C/Nc1ccc2nnc(c3ccccc3)n2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I18 compound treatment 96160.0 -28700.0 -1.11 92040.0 -30600.0 -1.15 -1.5979 -0.9999 1290576 Maybridge4_003362 Oc1ccc2c(=O)c(coc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I19 compound treatment 147560.0 22700.0 0.88 130080.0 7470.0 0.28 0.8218 0.8881 3064860 Maybridge4_003363 Cc1ccc(Cc2cc(C)n[nH]c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I20 compound treatment 123560.0 -1270.0 -0.05 125360.0 2750.0 0.1 0.0381 0.3331 1499068 Maybridge4_003364 CC(=O)NC1C(c2ccccc2)S(=O)(=O)c3ccccc3NC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I21 compound treatment 117000.0 -7830.0 -0.3 116360.0 -6250.0 -0.23 -0.3808 -0.9919 1721722 Maybridge4_003365 CC(=O)N1CCc2cc(NC(=S)NCc3cccs3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I22 compound treatment 114320.0 -10500.0 -0.41 124360.0 1750.0 0.07 -0.242 -0.5859 1210152 Maybridge4_003366 CCC(=O)N1C(CC(=Nc2ccccc12)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I23 mock treatment 139600.0 14800.0 0.57 135400.0 12800.0 0.48 0.7446 0.9961 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 I24 mock treatment 116560.0 -8270.0 -0.32 112160.0 -10500.0 -0.39 -0.5043 -0.995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J01 compound treatment 122240.0 -2590.0 -0.1 95640.0 -27000.0 -1.01 -0.7869 -0.7735 1243119 Maybridge4_003367 Cc1c(O)c(c2ccccc2)c(=O)n(c3ccccn3)c1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J02 compound treatment 8560.0 -116000.0 -4.51 6720.0 -116000.0 -4.35 -6.2656 -0.9998 1140611 Maybridge4_003368 CCCCc1c(O)cc(c2ccccc2)n(Cc3ccccc3)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J03 compound treatment 123880.0 -950.0 -0.04 120920.0 -1690.0 -0.06 -0.071 -0.9665 3178591 Maybridge4_003369 Cc1ccc(cc1)C(=O)/C=C\2/NCCNC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J04 compound treatment 151000.0 26200.0 1.02 136320.0 13700.0 0.51 1.0818 0.9504 3178682 Maybridge4_003370 CC(=O)O[C@H]1[C@H](O[C@@H]2OC(C)(C)O[C@H]12)C(O)CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J05 compound treatment 118240.0 -6590.0 -0.26 113040.0 -9570.0 -0.36 -0.4348 -0.9861 1447328 Maybridge4_003371 CC(C)(C)C(=O)CC(Nc1ccccc1)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J06 compound treatment 92160.0 -32700.0 -1.27 98320.0 -24300.0 -0.91 -1.541 -0.9869 1256088 Maybridge4_003372 C=CCC1(CCCCC1)NCCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J07 compound treatment 157640.0 32800.0 1.27 136800.0 14200.0 0.53 1.2767 0.9252 1171716 Maybridge4_003373 CN1CCCC(C1)OC(=O)C2=C(C)NC3(O)c4ccccc4C(=O)C23O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J08 compound treatment 38600.0 -86200.0 -3.35 55680.0 -66900.0 -2.51 -4.1421 -0.99 1583880 Maybridge4_003374 CC(C)(C)Oc1ccc(CC(CO)NC(=O)OCC2c3ccccc3-c4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J09 compound treatment 88080.0 -36800.0 -1.43 86280.0 -36300.0 -1.36 -1.9725 -0.9998 1604468 Maybridge4_003375 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccccc3Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J10 compound treatment 19880.0 -105000.0 -4.07 14000.0 -109000.0 -4.08 -5.7619 -1.0 3064861 Maybridge4_003376 Cc1cc(OC(=O)c2ccco2)nc(SCc3c(Cl)cccc3Cl)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J11 compound treatment 152040.0 27200.0 1.06 140440.0 17800.0 0.67 1.2197 0.9758 3178683 Maybridge4_003377 CC(C)C1(C)N2C(=O)c3ccccc3C2=NC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J12 compound treatment 134760.0 9930.0 0.39 128880.0 6270.0 0.24 0.4388 0.972 3064862 Maybridge4_003378 O=C1CS/C(=N\C2CC2)/N1Cc3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J13 compound treatment 148640.0 23800.0 0.92 142800.0 20200.0 0.76 1.189 0.9952 1167872 Maybridge4_003379 OC(=O)CNC(=O)CSc1ccccn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J14 compound treatment 145800.0 21000.0 0.81 144960.0 22300.0 0.84 1.1684 0.9999 1457281 Maybridge4_003380 COCc1cc(OC(=O)N(C)C)nc(n1)c2ccncc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J15 compound treatment 149800.0 25000.0 0.97 135640.0 13000.0 0.49 1.0308 0.9499 3178684 Maybridge4_003381 CN(C)/C=N/n1cnc2sc3CCCCc3c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J16 compound treatment 104400.0 -20400.0 -0.79 95240.0 -27400.0 -1.03 -1.287 -0.9918 3178685 Maybridge4_003382 NC(=N)NC(=N)Nc1cc(n[nH]1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J17 compound treatment 142160.0 17300.0 0.67 128360.0 5750.0 0.22 0.628 0.8893 1294257 Maybridge4_003383 COc1cc(Cc2cc(OC)c(C)cc2OC)c(OC)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J18 compound treatment 135480.0 10700.0 0.41 111400.0 -11200.0 -0.42 -0.0054 -0.0091 3178686 Maybridge4_003384 CCCCc1c(C)nc(nc1O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J19 compound treatment 107760.0 -17100.0 -0.66 108760.0 -13900.0 -0.52 -0.836 -0.9928 3176922 Maybridge4_003385 OC[C@H]1O[C@H](C[C@@H]1O)n2cc(Br)c(=O)[nH]c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J20 compound treatment 90440.0 -34400.0 -1.33 90440.0 -32200.0 -1.21 -1.7973 -0.9988 3064863 Maybridge4_003386 COc1cc(/C=N/c2ccc(Cl)cc2)ccc1OC(=O)/C=C/c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J21 compound treatment 92800.0 -32000.0 -1.24 104800.0 -17800.0 -0.67 -1.3515 -0.9577 1169652 Maybridge4_003387 C1CN(CCO1)c2c3CCc4ccccc4-c3nc5ccccc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J22 compound treatment 64520.0 -60300.0 -2.34 11400.0 -111000.0 -4.17 -4.6061 -0.9626 1608425 Maybridge4_003388 CCCC1=NN(C(=O)C(C)(C)C)C(=O)C1Cc2c(F)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J23 mock treatment 131440.0 6610.0 0.26 134560.0 11900.0 0.45 0.4984 0.9649 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 J24 mock treatment 124920.0 90.0 0.0 118080.0 -4530.0 -0.17 -0.1178 -0.6924 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K01 compound treatment 54360.0 -70500.0 -2.73 6440.0 -116000.0 -4.36 -5.0165 -0.9747 3064864 Maybridge4_003389 CSC1=N/C(=C\c2ccccc2O)/C(=O)N1Cc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K02 compound treatment 88560.0 -36300.0 -1.41 54320.0 -68300.0 -2.56 -2.8075 -0.9601 1422721 Maybridge4_003390 CCOC(=O)c1cnn(C(=O)COc2ccc(C)c3CCCc32)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K03 compound treatment 76400.0 -48400.0 -1.88 49520.0 -73100.0 -2.74 -3.2685 -0.983 3178687 Maybridge4_003391 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1CCc3c[nH]c4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K04 compound treatment 122960.0 -1870.0 -0.07 132240.0 9630.0 0.36 0.2042 0.5541 1502240 Maybridge4_003392 COC(=O)c1[nH]c(C(=O)OC)c(O)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K05 compound treatment 131680.0 6850.0 0.27 119280.0 -3330.0 -0.13 0.0995 0.3387 3064865 Maybridge4_003393 COc1cccc(NC(=O)c2cnccc2C(F)(F)F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K06 compound treatment 132600.0 7770.0 0.3 125880.0 3270.0 0.12 0.2999 0.9214 3178688 Maybridge4_003394 CCOC(=O)/C=C(\C)/Nc1cccc(N\C(=C\C(=O)OCC)\C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K07 compound treatment 140160.0 15300.0 0.59 118240.0 -4370.0 -0.16 0.3046 0.4936 3064866 Maybridge4_003395 FC(F)(F)c1ccc(cc1)c2nc(NC(=O)Nc3ccccc3)cs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K08 compound treatment 12400.0 -112000.0 -4.36 8880.0 -114000.0 -4.27 -6.103 -0.9999 1570272 Maybridge4_003396 CCC1N(CCc2c1[nH]c3ccccc23)C(=O)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K09 compound treatment 127920.0 3090.0 0.12 86120.0 -36500.0 -1.37 -0.8837 -0.6428 3064867 Maybridge4_003397 FC(F)(F)c1ccncc1C(=O)NC(=O)Nc2ccc(Cl)cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K10 compound treatment 117640.0 -7190.0 -0.28 106800.0 -15800.0 -0.59 -0.6169 -0.9407 1687043 Maybridge4_003398 Cc1cc(C)c(COc2ccc3C(=O)CC(C)(C)Oc3c2C)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K11 compound treatment 151800.0 27000.0 1.05 133040.0 10400.0 0.39 1.0167 0.91 3064868 Maybridge4_003399 FC(F)(F)c1ccc(nc1)n2nc(oc2=O)c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K12 compound treatment 32040.0 -92800.0 -3.6 14640.0 -108000.0 -4.05 -5.4113 -0.9983 1713701 Maybridge4_003400 COc1cccc(c1)C2CCN(CC2)C(=O)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K13 compound treatment 29840.0 -95000.0 -3.69 41280.0 -81300.0 -3.05 -4.7646 -0.9956 3064869 Maybridge4_003401 Cc1cc(C)c2c(=O)cc(oc2c1)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K14 compound treatment 130280.0 5450.0 0.21 127440.0 4830.0 0.18 0.2776 0.997 3178689 Maybridge4_003402 FC(F)(F)c1ccc(cc1)C(=O)Nc2cccnc2Sc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K15 compound treatment 118720.0 -6110.0 -0.24 85200.0 -37400.0 -1.4 -1.1605 -0.815 1294252 Maybridge4_003403 CCOC(=O)c1cnn2c1nc(Sc3ccc(C)cc3)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K16 compound treatment 66080.0 -58800.0 -2.28 61880.0 -60700.0 -2.28 -3.2236 -1.0 1553374 Maybridge4_003404 C1CN(CCO1)c2nnc(c3ccccc3)c(n2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K17 compound treatment 123880.0 -950.0 -0.04 111800.0 -10800.0 -0.41 -0.313 -0.7682 1663105 Maybridge4_003405 COc1ccc(Cc2cc(n[nH]c2=O)c3cccs3)c(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K18 compound treatment 138160.0 13300.0 0.52 119520.0 -3090.0 -0.12 0.2836 0.5351 3064947 Maybridge4_003406 OC[C@H]1OC(Oc2ccc(cc2)c3coc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K19 compound treatment 151720.0 26900.0 1.04 137600.0 15000.0 0.56 1.1355 0.958 1252838 Maybridge4_003407 Cc1cc(C)n(NC(=S)NC2CCCC2)c(=O)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K20 compound treatment 104800.0 -20000.0 -0.78 97840.0 -24800.0 -0.93 -1.207 -0.996 1353357 Maybridge4_003408 S=C1CC(Sc2ccccc2N1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K21 compound treatment 86640.0 -38200.0 -1.48 79760.0 -42900.0 -1.61 -2.185 -0.9992 1332355 Maybridge4_003409 CC(=O)N1CCc2cc(NC(=S)NC3CCCCCC3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K22 compound treatment 134520.0 9690.0 0.38 114000.0 -8610.0 -0.32 0.0373 0.0752 3064948 Maybridge4_003410 CNC(=O)c1cc(OC)ccc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K23 mock treatment 127960.0 3130.0 0.12 130080.0 7470.0 0.28 0.2841 0.93 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 K24 mock treatment 121600.0 -3230.0 -0.13 106640.0 -16000.0 -0.6 -0.5125 -0.8368 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L01 compound treatment 118240.0 -6590.0 -0.26 103680.0 -18900.0 -0.71 -0.6833 -0.9048 3064949 Maybridge4_003411 Cc1ncc(CO)c(/C=N/O)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L02 compound treatment 129760.0 4930.0 0.19 115200.0 -7410.0 -0.28 -0.0615 -0.182 2085598 Maybridge4_003412 CSc1sc(=S)sc1SC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L03 compound treatment 122240.0 -2590.0 -0.1 96280.0 -26300.0 -0.99 -0.7699 -0.775 1341478 Maybridge4_003413 NNC(=O)CC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L04 compound treatment 102560.0 -22300.0 -0.86 93560.0 -29100.0 -1.09 -1.382 -0.9934 1914392 Maybridge4_003414 O=C(c1ccccc1)n2ccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L05 compound treatment 75880.0 -49000.0 -1.9 113440.0 -9170.0 -0.34 -1.5864 -0.8219 3178690 Maybridge4_003415 C(SC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L06 compound treatment 145280.0 20500.0 0.79 124960.0 2350.0 0.09 0.6234 0.7808 1103414 Maybridge4_003416 OC(=O)C1CCCN1C(=O)OCC2c3ccccc3-c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L07 compound treatment 16280.0 -109000.0 -4.21 10440.0 -112000.0 -4.21 -5.9551 -1.0 3064950 Maybridge4_003417 Oc1ccccc1c2cc(c(C#N)c(=O)[nH]2)c3ccc4OCOc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L08 compound treatment 107640.0 -17200.0 -0.67 80200.0 -42400.0 -1.59 -1.5972 -0.9254 3178691 Maybridge4_003418 FC(F)(F)c1cccc(c1)N2CCN(CC2)C3=Cc4ccccc4C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L09 compound treatment 148720.0 23900.0 0.93 131000.0 8390.0 0.31 0.878 0.8969 3064952 Maybridge4_003419 O=C(/C=C\1/NCCOC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L10 compound treatment 143080.0 18300.0 0.71 138000.0 15400.0 0.58 0.9091 0.9949 1604086 Maybridge4_003420 Clc1cccc(Cl)c1Cn2nnc(n2)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L11 compound treatment 102480.0 -22400.0 -0.87 93200.0 -29400.0 -1.1 -1.3938 -0.9929 1004954 Maybridge4_003421 N(C(=Nc1ccccc1)Nc2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L12 compound treatment 128120.0 3290.0 0.13 124400.0 1790.0 0.07 0.1377 0.9549 3178692 Maybridge4_003422 CC1CN(CC(C)O1)c2ccc(NC(=S)NCc3ccco3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L13 compound treatment 141840.0 17000.0 0.66 141760.0 19100.0 0.72 0.9748 0.9991 3178693 Maybridge4_003423 FC(F)(F)C(NC(=O)Oc1ccccc1)(Oc2ccccc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L14 compound treatment 141480.0 16700.0 0.65 144640.0 22000.0 0.83 1.0414 0.9926 3064954 Maybridge4_003424 COCc1cc(O)nc(SCC(=O)C(C)(C)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L15 compound treatment 158400.0 33600.0 1.3 131920.0 9310.0 0.35 1.168 0.8661 1022292 Maybridge4_003425 O=C1NC(Cc2ccccc2)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L16 compound treatment 108280.0 -16600.0 -0.64 71600.0 -51000.0 -1.91 -1.8079 -0.8953 3064955 Maybridge4_003426 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nnn(CC(=O)c3ccc(Cl)cc3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L17 compound treatment 11400.0 -113000.0 -4.4 8160.0 -114000.0 -4.3 -6.1495 -0.9999 1517030 Maybridge4_003427 CC(=O)Oc1ccc(OC(=O)C)c2cc3c(OC(=O)C)ccc(OC(=O)C)c3cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L18 compound treatment 119440.0 -5390.0 -0.21 105320.0 -17300.0 -0.65 -0.6068 -0.8899 3064957 Maybridge4_003428 CCN(CC)C(=S)Oc1nc(nc(C)c1CC(=C)C)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L19 compound treatment 142200.0 17400.0 0.67 130360.0 7750.0 0.29 0.6822 0.9294 1414175 Maybridge4_003429 NNC(=O)C1C(C1c2ccccc2)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L20 compound treatment 113280.0 -11600.0 -0.45 101200.0 -21400.0 -0.8 -0.8852 -0.962 1151671 Maybridge4_003430 CC(C)(C)C(=O)CSc1nc2ccccc2c(=O)n1CC3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L21 compound treatment 95880.0 -29000.0 -1.12 94320.0 -28300.0 -1.06 -1.5451 -0.9996 1294591 Maybridge4_003431 C1CCN(CC1)c2cc(nc3ccccc23)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L22 compound treatment 9200.0 -116000.0 -4.49 7560.0 -115000.0 -4.32 -6.2258 -0.9998 3178694 Maybridge4_003432 CCCC1=NN(C(=O)/C=C/c2cccs2)C(=O)C1Cc3c(F)cccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L23 mock treatment 125400.0 570.0 0.02 113040.0 -9570.0 -0.36 -0.2384 -0.6623 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 L24 mock treatment 112440.0 -12400.0 -0.48 109880.0 -12700.0 -0.48 -0.6778 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M01 compound treatment 113760.0 -11100.0 -0.43 101000.0 -21600.0 -0.81 -0.8773 -0.9558 1614322 Maybridge4_003433 CC(C)NC(=O)N(Cc1ccccc1)Cc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M02 compound treatment 132200.0 7370.0 0.29 109960.0 -12700.0 -0.47 -0.1336 -0.241 1632856 Maybridge4_003434 CCCCn1c(O)cc(C)c(C#N)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M03 compound treatment 47640.0 -77200.0 -2.99 32240.0 -90400.0 -3.39 -4.5162 -0.9981 3178695 Maybridge4_003435 CSC1=N/C(=C\Nc2cccc(Cl)c2)/C(=O)N1Cc3cccc(Cl)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M04 compound treatment 111520.0 -13300.0 -0.52 89080.0 -33500.0 -1.26 -1.2551 -0.9226 1626500 Maybridge4_003436 S=C(NCC1CC1)Nc2ccc3[nH]ccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M05 compound treatment 122680.0 -2150.0 -0.08 98720.0 -23900.0 -0.9 -0.6931 -0.7696 3178774 Maybridge4_003437 FC(F)(F)c1ccncc1C(=O)Nc2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M06 compound treatment 139040.0 14200.0 0.55 130800.0 8190.0 0.31 0.6072 0.9619 3064958 Maybridge4_003438 NNC(=O)CC1=Nn2c(nnc2SC1)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M07 compound treatment 93800.0 -31000.0 -1.2 57080.0 -65500.0 -2.46 -2.5905 -0.946 3178775 Maybridge4_003439 CCN(Cc1cc(Cl)cc(Cl)c1)C(=O)c2cnc(OC)cc2C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M08 compound treatment 136760.0 11900.0 0.46 111200.0 -11400.0 -0.43 0.0244 0.0387 1042478 Maybridge4_003440 CNc1cc(=O)n(C)c(=O)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M09 compound treatment 132640.0 7810.0 0.3 109040.0 -13600.0 -0.51 -0.1459 -0.2462 3064959 Maybridge4_003441 Fc1ccc(NC(=O)c2cnccc2C(F)(F)F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M10 compound treatment 102800.0 -22000.0 -0.85 68280.0 -54300.0 -2.04 -2.0463 -0.9255 1313888 Maybridge4_003442 COc1cc(ccc1O)C2=NC(O)C(=O)Nc3ccc(Cl)cc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M11 compound treatment 102440.0 -22400.0 -0.87 86600.0 -36000.0 -1.35 -1.57 -0.9772 3064960 Maybridge4_003443 NNC(=O)c1cc(OCC(F)(F)F)nc(OCC(F)(F)F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M12 compound treatment 128120.0 3290.0 0.13 119240.0 -3370.0 -0.13 8.0E-4 0.0042 3178776 Maybridge4_003444 Fc1ccc(cc1)c2nnc(CSCc3cccc4ccccc34)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M13 compound treatment 100120.0 -24700.0 -0.96 85520.0 -37100.0 -1.39 -1.6623 -0.9834 3178777 Maybridge4_003445 Clc1ccc(cc1)C(=O)CC(C(=O)c2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M14 compound treatment 138640.0 13800.0 0.54 107600.0 -15000.0 -0.56 -0.0195 -0.0251 3064961 Maybridge4_003446 Nn1c(cc(c(C#N)c1=O)C(F)(F)F)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M15 compound treatment 139640.0 14800.0 0.57 111400.0 -11200.0 -0.42 0.1088 0.1527 3178778 Maybridge4_003447 CCOC(=O)c1cnn2c1nc(Oc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M16 compound treatment 128400.0 3570.0 0.14 93120.0 -29500.0 -1.11 -0.6848 -0.6138 1593342 Maybridge4_003448 CC(C)NC(=O)c1cccc2cccc(Sc3ccccc3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M17 compound treatment 71240.0 -53600.0 -2.08 23720.0 -98900.0 -3.71 -4.0948 -0.9625 1609655 Maybridge4_003449 O=c1[nH]nc(cc1CC2CCCCC2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M18 compound treatment 134640.0 9810.0 0.38 108640.0 -14000.0 -0.52 -0.1017 -0.1569 1690877 Maybridge4_003450 O=c1n(c2ccccc2)c(=O)n3C4CCC(C4)n31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M19 compound treatment 135680.0 10900.0 0.42 111200.0 -11400.0 -0.43 -0.0052 -0.0087 1634815 Maybridge4_003451 Cc1cc(C)n(NC(=S)NCc2cccs2)c(=O)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M20 compound treatment 111880.0 -13000.0 -0.5 108880.0 -13700.0 -0.52 -0.7197 -0.9999 3065001 Maybridge4_003452 C1Sc2ccccc2C3=Nc4ccccc4SC(C13)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M21 compound treatment 44200.0 -80600.0 -3.13 13200.0 -109000.0 -4.11 -5.1159 -0.991 3065002 Maybridge4_003453 CN(C)/C=C/C(=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(C)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M22 compound treatment 124920.0 90.0 0.0 100880.0 -21700.0 -0.82 -0.5743 -0.7041 3065003 Maybridge4_003454 NC(=O)c1cc(Cl)ccc1I 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M23 mock treatment 130960.0 6130.0 0.24 118840.0 -3770.0 -0.14 0.0681 0.2459 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 M24 mock treatment 122560.0 -2270.0 -0.09 114120.0 -8490.0 -0.32 -0.2877 -0.8699 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N01 compound treatment 99440.0 -25400.0 -0.99 56760.0 -65900.0 -2.47 -2.4443 -0.9187 1588083 Maybridge4_003455 CC(=O)Oc1ccc(cc1)c2coc3cc(OC(=O)C)cc(OC(=O)C)c3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N02 compound treatment 62040.0 -62800.0 -2.44 23480.0 -99100.0 -3.72 -4.3536 -0.9789 1124592 Maybridge4_003456 CC1CC2(CCCCC2)N(Cc3ccccc13)S(=O)(=O)c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N03 compound treatment 126200.0 1370.0 0.05 96720.0 -25900.0 -0.97 -0.6496 -0.6674 3065004 Maybridge4_003457 CNC(=S)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N04 compound treatment 111760.0 -13100.0 -0.51 64640.0 -58000.0 -2.18 -1.8971 -0.8492 1007974 Maybridge4_003458 O=C(Nc1ccccc1)OC2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N05 compound treatment 10520.0 -114000.0 -4.44 6800.0 -116000.0 -4.35 -6.2097 -0.9999 3178779 Maybridge4_003459 CC(CNc1ccccc1)/C(=N/c2ccccc2)/Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N06 compound treatment 140000.0 15200.0 0.59 115680.0 -6930.0 -0.26 0.2322 0.3608 1711036 Maybridge4_003460 CC1(C)c2ccccc2N3CC(=O)N(CC=C)C31C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N07 compound treatment 117240.0 -7590.0 -0.29 110440.0 -12200.0 -0.46 -0.5313 -0.9774 854262 Maybridge4_003461 CC(N)(Cc1cccc(O)c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N08 compound treatment 84760.0 -40100.0 -1.55 58840.0 -63800.0 -2.39 -2.7918 -0.9782 1129507 Maybridge4_003462 CC(N(C(=O)c1sc2ccccc2c1Cl)c3ccccn3)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N09 compound treatment 133880.0 9050.0 0.35 108680.0 -13900.0 -0.52 -0.1215 -0.1928 1387784 Maybridge4_003463 COc1ccc(Sc2ccccc2COC(=O)C)c(c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N10 compound treatment 140480.0 15700.0 0.61 123360.0 748.0 0.03 0.4492 0.739 1366361 Maybridge4_003464 NNC(=O)Cn1nnc(n1)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N11 compound treatment 136920.0 12100.0 0.47 130480.0 7870.0 0.3 0.5405 0.9751 3178780 Maybridge4_003465 CC1(C)NCS[C@H]1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N12 compound treatment 77480.0 -47400.0 -1.84 76400.0 -46200.0 -1.73 -2.5255 -0.9996 2078075 Maybridge4_003466 CC[n+]1c(C)csc1Nc2ccc(cc2)N3CC(C)OC(C)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N13 compound treatment 12120.0 -113000.0 -4.37 9760.0 -113000.0 -4.24 -6.0873 -0.9999 3178781 Maybridge4_003467 CCOC(NC(=O)Nc1ccc(Br)cc1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N14 compound treatment 107240.0 -17600.0 -0.68 109520.0 -13100.0 -0.49 -0.8301 -0.987 3065007 Maybridge4_003468 FC(F)(F)c1cc(=O)oc2cc(NC(=O)c3cc(Cl)cc(Cl)c3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N15 compound treatment 77200.0 -47600.0 -1.85 66960.0 -55700.0 -2.09 -2.7837 -0.9981 1675436 Maybridge4_003469 CCOC(=O)c1c(C)n(O)c2ccc3nonc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N16 compound treatment 125720.0 890.0 0.03 109000.0 -13600.0 -0.51 -0.3368 -0.6578 1084802 Maybridge4_003470 CC(C)CCc1c(C)nc(N)nc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N17 compound treatment 121240.0 -3590.0 -0.14 92280.0 -30300.0 -1.14 -0.9035 -0.7878 1383041 Maybridge4_003471 Clc1ccc(C(=O)N2CCC(CC2)NC(=O)c3ccccc3)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N18 compound treatment 18360.0 -106000.0 -4.13 8840.0 -114000.0 -4.27 -5.9405 -0.9999 3065008 Maybridge4_003472 CS/C(=N/C(C)(C)C)/Nc1ccccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N19 compound treatment 138360.0 13500.0 0.52 112720.0 -9890.0 -0.37 0.1087 0.169 1673966 Maybridge4_003473 Cc1c(NC(=O)C(C)(C)C)c(=O)n(c2ccccc2)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N20 compound treatment 109600.0 -15200.0 -0.59 64760.0 -57900.0 -2.17 -1.9532 -0.868 1479223 Maybridge4_003474 Cc1cc(Nc2ccc(F)c(Cl)c2)nc(NC(=O)C(C)(C)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N21 compound treatment 7480.0 -117000.0 -4.55 5440.0 -117000.0 -4.4 -6.3292 -0.9998 1920716 Maybridge4_003475 CC(C)COc1ccc(cc1)/C(=N\O)/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N22 compound treatment 46120.0 -78700.0 -3.05 14840.0 -108000.0 -4.04 -5.0197 -0.9904 3178782 Maybridge4_003476 CC(=C)CC1C(=NN(C1=O)S(=O)(=O)c2ccccc2Cl)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N23 mock treatment 120800.0 -4030.0 -0.16 105120.0 -17500.0 -0.66 -0.5748 -0.8517 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 N24 mock treatment 117320.0 -7510.0 -0.29 98200.0 -24400.0 -0.92 -0.8539 -0.8882 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O01 compound treatment 102280.0 -22600.0 -0.87 74520.0 -48100.0 -1.8 -1.895 -0.9447 3178783 Maybridge4_003477 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1CCOc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O02 compound treatment 6880.0 -118000.0 -4.58 4600.0 -118000.0 -4.43 -6.368 -0.9999 3065009 Maybridge4_003478 Cc1ccc(OCc2nnc(S)n2C3CCCCC3)c4CCCc41 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O03 compound treatment 132840.0 8010.0 0.31 97280.0 -25300.0 -0.95 -0.4525 -0.4524 1042314 Maybridge4_003479 CNC(=O)Nc1cccc2cccnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O04 compound treatment 90840.0 -34000.0 -1.32 53920.0 -68700.0 -2.58 -2.7556 -0.9515 1378461 Maybridge4_003480 S=C(NC1CCCCC1)Nc2ccc3[nH]ccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O05 compound treatment 149400.0 24600.0 0.95 102200.0 -20400.0 -0.77 0.1324 0.1082 3178784 Maybridge4_003481 FC(F)(F)c1ccncc1C(=O)NCc2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O06 compound treatment 108080.0 -16800.0 -0.65 71640.0 -51000.0 -1.91 -1.8123 -0.897 3065010 Maybridge4_003482 CC(C)(C)C(=S)Nc1cccc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O07 compound treatment 140000.0 15200.0 0.59 94960.0 -27700.0 -1.04 -0.3177 -0.2662 3178785 Maybridge4_003483 COc1cccc(CNC(=O)c2cnc(OC)cc2C(F)(F)F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O08 compound treatment 149440.0 24600.0 0.95 86960.0 -35700.0 -1.34 -0.271 -0.1648 1115300 Maybridge4_003484 NNC(=O)COc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O09 compound treatment 145240.0 20400.0 0.79 92000.0 -30600.0 -1.15 -0.2525 -0.1809 3178786 Maybridge4_003485 NC(=O)C1=CN(CCC1C(F)(F)F)C(=O)Nc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O10 compound treatment 134000.0 9170.0 0.36 110080.0 -12500.0 -0.47 -0.081 -0.1374 1008942 Maybridge4_003486 Cc1cccc(NC(=O)Nc2cccc(C)c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O11 compound treatment 69400.0 -55400.0 -2.15 46960.0 -75700.0 -2.84 -3.5285 -0.9906 3178787 Maybridge4_003487 FC(F)(F)COc1ncccc1C(=O)NCc2ccc(Cl)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O12 compound treatment 92320.0 -32500.0 -1.26 66480.0 -56100.0 -2.11 -2.3816 -0.9699 1449652 Maybridge4_003488 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(CNC(=O)c4ccccc4)s3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O13 compound treatment 118240.0 -6590.0 -0.26 111200.0 -11400.0 -0.43 -0.4837 -0.9696 3178788 Maybridge4_003489 COC(=O)c1cc2cc(Br)ccc2c(Br)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O14 compound treatment 129360.0 4530.0 0.18 140360.0 17700.0 0.67 0.5953 0.8641 1523809 Maybridge4_003490 CCOC(=O)COc1nc(C)c(CC=C)c(C)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O15 compound treatment 80280.0 -44600.0 -1.73 13800.0 -109000.0 -4.08 -4.11 -0.9268 1444175 Maybridge4_003491 CCOC(=O)c1cnn2c1nc(N3CC(C)CC(C)C3)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O16 compound treatment 11680.0 -113000.0 -4.39 7320.0 -115000.0 -4.33 -6.1641 -1.0 3065040 Maybridge4_003492 O=C1/C(=C/c2ccc3ccccc3c2)/COc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O17 compound treatment 132440.0 7610.0 0.3 112960.0 -9650.0 -0.36 -0.0474 -0.1014 3065041 Maybridge4_003493 Cc1cc(CO)cc(C)c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O18 compound treatment 136080.0 11300.0 0.44 100480.0 -22100.0 -0.83 -0.2787 -0.297 1280927 Maybridge4_003494 O=c1n(c2ccccc2)c(=O)n3C4CC(C=C4)n31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O19 compound treatment 135120.0 10300.0 0.4 116200.0 -6410.0 -0.24 0.1121 0.2405 3065042 Maybridge4_003495 CC1=C(Sc2ccccc2N1)C(=O)Nn3cnc4cccc(F)c4c3=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O20 compound treatment 43600.0 -81200.0 -3.15 5640.0 -117000.0 -4.39 -5.3329 -0.9868 3065043 Maybridge4_003496 Cc1ccc(cc1)C2CC(=Nc3ccccc3S2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O21 compound treatment 124600.0 -230.0 -0.01 105560.0 -17100.0 -0.64 -0.4589 -0.7169 1222795 Maybridge4_003497 CCOC(=O)c1cnn(C(=O)COc2ccc(cc2C(C)(C)C)C(C)(C)C)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O22 compound treatment 8720.0 -116000.0 -4.51 5080.0 -118000.0 -4.41 -6.3048 -0.9999 3065044 Maybridge4_003498 Cc1cc(nc2CC(C)(C)C/C(=N/O)/c12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O23 mock treatment 132240.0 7410.0 0.29 119800.0 -2810.0 -0.11 0.1287 0.4201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 O24 mock treatment 132760.0 7930.0 0.31 110520.0 -12100.0 -0.45 -0.1034 -0.1885 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P01 compound treatment 3120.0 -122000.0 -4.72 1960.0 -121000.0 -4.53 -6.5412 -0.9998 1411988 Maybridge4_003499 O=C(CC#N)NC(=O)NC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P02 compound treatment 36640.0 -88200.0 -3.42 32680.0 -89900.0 -3.38 -4.8063 -1.0 1452749 Maybridge4_003500 CC1CC2(CCCCC2)N(Cc3ccccc13)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P03 compound treatment 6000.0 -119000.0 -4.61 4400.0 -118000.0 -4.44 -6.3974 -0.9998 2102798 Maybridge4_003501 COC(=O)/C=C\1/OC(=CC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P04 compound treatment 109480.0 -15400.0 -0.6 103320.0 -19300.0 -0.72 -0.9331 -0.9953 1582498 Maybridge4_003502 CC(=O)NC(=O)NCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P05 compound treatment 107880.0 -17000.0 -0.66 94640.0 -28000.0 -1.05 -1.2074 -0.9746 3065047 Maybridge4_003503 CCOC(=O)CC1=NC(=O)CS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P06 compound treatment 129000.0 4170.0 0.16 81960.0 -40700.0 -1.53 -0.9645 -0.6286 1631994 Maybridge4_003504 Cc1ccc2N3CC(=O)N(Cc4ccccc4)C3(C)C(C)(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P07 compound treatment 129320.0 4490.0 0.17 107000.0 -15600.0 -0.59 -0.2912 -0.4763 3065048 Maybridge4_003505 CC(=O)N1CC(O)C[C@H]1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P08 compound treatment 125640.0 810.0 0.03 100080.0 -22500.0 -0.85 -0.5758 -0.6804 3178789 Maybridge4_003506 CN1N=C(C)C(Cc2c(Cl)cccc2Cl)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P09 compound treatment 106440.0 -18400.0 -0.71 68400.0 -54200.0 -2.03 -1.9433 -0.9013 1247915 Maybridge4_003507 O=C(Oc1ccc(Oc2ccccc2)cc1)N3CCC(CC3)OC(=O)n4ccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P10 compound treatment 126440.0 1610.0 0.06 94080.0 -28500.0 -1.07 -0.7131 -0.6647 3065049 Maybridge4_003508 CN(C)/N=C(\Cn1nnc(n1)N2CCCC2)/c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P11 compound treatment 135760.0 10900.0 0.42 104120.0 -18500.0 -0.69 -0.1909 -0.2347 1294581 Maybridge4_003509 OC(=O)c1ccc2cc[nH]c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P12 compound treatment 97720.0 -27100.0 -1.05 77360.0 -45300.0 -1.7 -1.9447 -0.9735 1153919 Maybridge4_003510 CC(C)(C)c1ccc(NC(=S)NCc2cccnc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P13 compound treatment 131880.0 7050.0 0.27 98600.0 -24000.0 -0.9 -0.4438 -0.4713 3178790 Maybridge4_003511 CN(C)C(=O)NC(Nc1cc(C)on1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P14 compound treatment 132280.0 7450.0 0.29 110520.0 -12100.0 -0.45 -0.1165 -0.2166 1634696 Maybridge4_003512 OCN1N=C(CCC1=O)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P15 compound treatment 125680.0 850.0 0.03 102560.0 -20100.0 -0.75 -0.5089 -0.6755 1538301 Maybridge4_003513 OC(=O)CCn1nc(Nc2ccccc2)n(c3ccccc3)c1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P16 compound treatment 111880.0 -13000.0 -0.5 89680.0 -32900.0 -1.24 -1.2293 -0.9213 3065050 Maybridge4_003514 COCc1nc(S)nc(O)c1Cc2c(F)cccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P17 compound treatment 96760.0 -28100.0 -1.09 65280.0 -57300.0 -2.15 -2.2917 -0.9502 1358448 Maybridge4_003515 COc1ccccc1C2CCN(CC2)C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P18 compound treatment 111280.0 -13600.0 -0.53 94880.0 -27700.0 -1.04 -1.1077 -0.95 3065051 Maybridge4_003516 CC(C)(C)NC(=S)NCC1CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P19 compound treatment 92160.0 -32700.0 -1.27 60440.0 -62200.0 -2.33 -2.5463 -0.9589 1357507 Maybridge4_003517 Clc1ccc(Nc2ccc(nn2)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P20 compound treatment 5240.0 -120000.0 -4.64 4000.0 -119000.0 -4.45 -6.4289 -0.9998 1680143 Maybridge4_003518 Cc1cc(Nc2ccc(F)cc2)nc(SCc3c(Cl)cccc3Cl)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P21 compound treatment 106480.0 -18400.0 -0.71 95400.0 -27200.0 -1.02 -1.2256 -0.9844 1714479 Maybridge4_003519 CCOC(=O)N1CCN(CC(O)Cn2c(=O)n(C)c3ncn(C)c3c2=O)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P22 compound treatment 5040.0 -120000.0 -4.65 3720.0 -119000.0 -4.46 -6.4418 -0.9998 3178866 Maybridge4_003520 CCCC1=NN(C(=O)C1CC=C)S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P23 mock treatment 116400.0 -8430.0 -0.33 103040.0 -19600.0 -0.73 -0.7507 -0.9336 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2058 P24 mock treatment 109440.0 -15400.0 -0.6 111800.0 -10800.0 -0.41 -0.7092 -0.9823 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A01 compound treatment 121080.0 -17200.0 -0.67 102520.0 -27500.0 -1.03 -1.2018 -0.9781 3178890 Maybridge4_004577 CC(C)(C)c1ccc(SC(=O)c2ccc(OCC(F)(F)F)nc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A02 compound treatment 81960.0 -56400.0 -2.19 102040.0 -27900.0 -1.05 -2.2878 -0.9434 1333720 Maybridge4_004578 COc1ccc(OCc2ncc(s2)c3ccc4OCCCOc4c3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A03 compound treatment 77360.0 -61000.0 -2.37 91960.0 -38000.0 -1.43 -2.6815 -0.9707 1593366 Maybridge4_004579 Cc1nn(c(N)c1c2nc(cs2)c3ccccc3)c4cc(Cl)ccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A04 compound treatment 131120.0 -7200.0 -0.28 160920.0 30900.0 1.16 0.6235 0.5221 3178891 Maybridge4_004580 Cc1ccc(cc1F)c2nc(cs2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A05 compound treatment 122560.0 -15800.0 -0.61 169080.0 39100.0 1.47 0.6053 0.3807 3065742 Maybridge4_004581 FC(F)(F)Oc1ccc(cc1)C(=O)Nc2ccc(nc2)N3CCC(CC3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A06 compound treatment 130280.0 -8040.0 -0.31 192560.0 62600.0 2.35 1.4402 0.6079 3178892 Maybridge4_004582 Cc1c(C#N)c(SCc2cccc(c2)C(F)(F)F)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A07 compound treatment 68200.0 -70100.0 -2.72 93480.0 -36500.0 -1.37 -2.8925 -0.9496 3178893 Maybridge4_004583 CCOC(=O)c1cc(C#N)c(Sc2ccc(C)cc2)nc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A08 compound treatment 98880.0 -39400.0 -1.53 144680.0 14700.0 0.55 -0.692 -0.4254 3065743 Maybridge4_004584 Cn1nc(c2cccc(c2)C3OCCO3)c(=O)n(C)c1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A09 compound treatment 97200.0 -41100.0 -1.6 130640.0 657.0 0.02 -1.1107 -0.6961 3178894 Maybridge4_004585 Cc1nc(cs1)C(=N)NC(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A10 compound treatment 109200.0 -29100.0 -1.13 143560.0 13600.0 0.51 -0.4386 -0.3539 3065744 Maybridge4_004586 CC1=N/C(=C\c2sccc2C)/C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A11 compound treatment 130760.0 -7560.0 -0.29 183160.0 53200.0 2.0 1.2039 0.5968 1220314 Maybridge4_004587 Cc1cc(C)n(Cc2ccccc2)c(=O)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A12 compound treatment 133840.0 -4480.0 -0.17 173800.0 43800.0 1.64 1.04 0.6289 3178895 Maybridge4_004588 Cc1ccccc1c2nnc(o2)c3cc(nn3Cc4ccc(F)cc4)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A13 compound treatment 117640.0 -20700.0 -0.8 124720.0 -5260.0 -0.2 -0.707 -0.8556 3178896 Maybridge4_004589 FC(F)(F)COc1ccc(cn1)c2nnc(SCc3ccccc3C(F)(F)F)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A14 compound treatment 8560.0 -130000.0 -5.03 12720.0 -117000.0 -4.4 -6.6721 -0.9978 3065746 Maybridge4_004590 CN(C)/C=C/C(=O)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A15 compound treatment 112960.0 -25400.0 -0.98 154240.0 24300.0 0.91 -0.052 -0.0388 3178897 Maybridge4_004591 CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N2CCN(CC2)C(=O)c3snnc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A16 compound treatment 90720.0 -47600.0 -1.85 137840.0 7860.0 0.29 -1.0974 -0.5868 3065747 Maybridge4_004592 CC1CCCCN1C(=S)Nc2cccc(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A17 compound treatment 150760.0 12400.0 0.48 179360.0 49400.0 1.85 1.6518 0.8625 3178898 Maybridge4_004593 FC(F)(F)c1ccc(nc1)c2nnc(c3ccccn3)c(n2)c4ccccn4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A18 compound treatment 39520.0 -98800.0 -3.83 99640.0 -30300.0 -1.14 -3.5159 -0.8792 3065748 Maybridge4_004594 CC(C)n1c(=S)[nH]c2cc(ccc12)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A19 compound treatment 5240.0 -133000.0 -5.16 20360.0 -110000.0 -4.11 -6.5604 -0.9937 3178899 Maybridge4_004595 COc1ccc(OCC(=N)NC(=S)Nc2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A20 compound treatment 5600.0 -133000.0 -5.15 8680.0 -121000.0 -4.55 -6.8605 -0.9981 3065749 Maybridge4_004596 Clc1ccc(NC(=C(C#N)C#N)NC(=O)c2ccccc2Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A21 compound treatment 35160.0 -103000.0 -4.0 65680.0 -64300.0 -2.41 -4.5368 -0.9707 3178900 Maybridge4_004597 FC(F)(F)c1cc(nc(Sc2ccccc2NC(=O)c3cccs3)c1C#N)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A22 mock treatment 152320.0 14000.0 0.54 162240.0 32300.0 1.21 1.2402 0.9346 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A23 mock treatment 137040.0 -1280.0 -0.05 152800.0 22800.0 0.86 0.5705 0.665 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 A24 mock treatment 138920.0 602.0 0.02 119400.0 -10600.0 -0.4 -0.2644 -0.6644 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B01 mock treatment 147120.0 8800.0 0.34 194800.0 64800.0 2.43 1.9617 0.7985 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B02 mock treatment 154760.0 16400.0 0.64 200000.0 70000.0 2.63 2.3093 0.854 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B03 mock treatment 145200.0 6880.0 0.27 218200.0 88200.0 3.31 2.53 0.7617 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B04 mock treatment 135840.0 -2480.0 -0.1 209000.0 79000.0 2.97 2.029 0.6838 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B05 mock treatment 158920.0 20600.0 0.8 229200.0 99200.0 3.72 3.1983 0.8398 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B06 mock treatment 137440.0 -878.0 -0.03 230120.0 100000.0 3.76 2.6334 0.7007 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B07 mock treatment 125080.0 -13200.0 -0.51 216120.0 86100.0 3.23 1.9228 0.5874 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B08 mock treatment 149520.0 11200.0 0.43 231040.0 101000.0 3.79 2.9893 0.783 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B09 mock treatment 128320.0 -10000.0 -0.39 208560.0 78600.0 2.95 1.811 0.6088 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B10 mock treatment 146160.0 7840.0 0.3 222320.0 92300.0 3.47 2.6657 0.7662 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B11 mock treatment 154040.0 15700.0 0.61 196360.0 66400.0 2.49 2.1929 0.855 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B12 mock treatment 194000.0 55700.0 2.16 223400.0 93400.0 3.51 4.0069 0.9729 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B13 mock treatment 165880.0 27600.0 1.07 201320.0 71300.0 2.68 2.6494 0.9189 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B14 mock treatment 153800.0 15500.0 0.6 231920.0 102000.0 3.83 3.1301 0.8082 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B15 mock treatment 149200.0 10900.0 0.42 217120.0 87100.0 3.27 2.6111 0.7918 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B16 mock treatment 131760.0 -6560.0 -0.25 210960.0 81000.0 3.04 1.9691 0.6456 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B17 mock treatment 121080.0 -17200.0 -0.67 206920.0 76900.0 2.89 1.5689 0.5293 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B18 mock treatment 110680.0 -27600.0 -1.07 203600.0 73600.0 2.76 1.1954 0.4033 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B19 mock treatment 149040.0 10700.0 0.42 219400.0 89400.0 3.36 2.6672 0.7887 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B20 mock treatment 138480.0 162.0 0.01 224840.0 94900.0 3.56 2.5218 0.7084 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B21 mock treatment 157880.0 19600.0 0.76 217280.0 87300.0 3.28 2.8535 0.8484 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B22 mock treatment 132480.0 -5840.0 -0.23 221440.0 91500.0 3.43 2.267 0.659 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B23 mock treatment 155040.0 16700.0 0.65 183320.0 53300.0 2.0 1.8743 0.8907 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 B24 mock treatment 157440.0 19100.0 0.74 152000.0 22000.0 0.83 1.1089 0.9986 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C01 compound treatment 108320.0 -30000.0 -1.16 146840.0 16900.0 0.63 -0.3757 -0.2836 3065750 Maybridge4_004598 FC(F)(F)c1cccc(NC(=O)CCn2cccc(c2=O)C(F)(F)F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C02 compound treatment 7760.0 -131000.0 -5.07 10880.0 -119000.0 -4.47 -6.7429 -0.9981 3178901 Maybridge4_004599 Oc1ccc2c(CSc3ccc(Cl)cc3)cc(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C03 compound treatment 110560.0 -27800.0 -1.08 162360.0 32400.0 1.22 0.0977 0.0602 3178902 Maybridge4_004600 CN(CCOC(=O)c1snnc1C)c2ccc(C#N)cn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C04 compound treatment 103560.0 -34800.0 -1.35 162320.0 32300.0 1.21 -0.0954 -0.0526 1339676 Maybridge4_004601 Cn1nc(cc1C(=O)Nc2cccnc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C05 compound treatment 112560.0 -25800.0 -1.0 147960.0 18000.0 0.67 -0.2296 -0.1904 3065771 Maybridge4_004602 CCCNC(=O)Nc1ccc(nc1)N2CCC(CC2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C06 compound treatment 53520.0 -84800.0 -3.29 89600.0 -40400.0 -1.52 -3.3982 -0.9381 1741890 Maybridge4_004603 Cc1cc(C(=O)Nc2ccc(C)cc2)n(Cc3ccc(C)cc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C07 compound treatment 109040.0 -29300.0 -1.14 129640.0 -343.0 -0.01 -0.8124 -0.7151 3065772 Maybridge4_004604 CCOC(=O)c1cc(C#N)c(Nc2ccccc2OC)nc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C08 compound treatment 109160.0 -29200.0 -1.13 170040.0 40100.0 1.5 0.2631 0.1398 3065773 Maybridge4_004605 N#Cc1ccc(nc1)N2CCCNCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C09 compound treatment 90600.0 -47700.0 -1.85 139960.0 9980.0 0.37 -1.0444 -0.5529 3065774 Maybridge4_004606 Cc1nc(cs1)C(=N)NC(=O)c2ccc(OC(F)(F)F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C10 compound treatment 116960.0 -21400.0 -0.83 174480.0 44500.0 1.67 0.5949 0.3191 3065775 Maybridge4_004607 N[C@@H](Cc1ccc(OC(F)(F)F)cc1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C11 compound treatment 139440.0 1120.0 0.04 190720.0 60700.0 2.28 1.6427 0.7205 3065776 Maybridge4_004608 Cn1c(SCC(=O)Nc2cccc(Cl)c2)nnc1c3ccc(OCC(F)(F)F)nc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C12 compound treatment 75680.0 -62600.0 -2.43 86200.0 -43800.0 -1.64 -2.8805 -0.9818 3065777 Maybridge4_004609 Cc1cc(nn1C(C)(C)C)C(=O)Nc2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C13 compound treatment 118280.0 -20000.0 -0.78 138000.0 8020.0 0.3 -0.337 -0.4042 3178903 Maybridge4_004610 CSc1nnc(c2cc(OCC(F)(F)F)nc(OCC(F)(F)F)c2)n1Cc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C14 compound treatment 60280.0 -78000.0 -3.03 74640.0 -55300.0 -2.08 -3.6098 -0.9831 3065778 Maybridge4_004611 Fc1ccc(SCC(=O)C2(CC3CC4CC(C3)C2)C4)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C15 compound treatment 85480.0 -52800.0 -2.05 105960.0 -24000.0 -0.9 -2.0872 -0.9319 3178904 Maybridge4_004612 FC(F)(F)c1ccc(nc1)c2nnc(SCC(=O)Nc3cccc(Cl)c3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C16 compound treatment 106120.0 -32200.0 -1.25 159520.0 29500.0 1.11 -0.0995 -0.0596 3065781 Maybridge4_004613 Cc1cccc(NC(=S)N2CCCCC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C17 compound treatment 8640.0 -130000.0 -5.03 13000.0 -117000.0 -4.39 -6.6624 -0.9977 3178905 Maybridge4_004614 Fc1cccc(c1)C(=O)CSC2=NNC(S2)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C18 compound treatment 67760.0 -70600.0 -2.74 122480.0 -7500.0 -0.28 -2.135 -0.7757 3065782 Maybridge4_004615 Cn1c(SCC=C)ncc1c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C19 compound treatment 50120.0 -88200.0 -3.42 79880.0 -50100.0 -1.88 -3.7495 -0.9602 3178906 Maybridge4_004616 Cc1ccc(NC(=S)NC(=N)COc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C20 compound treatment 36000.0 -102000.0 -3.97 100200.0 -29800.0 -1.12 -3.5976 -0.8723 3065783 Maybridge4_004617 Sc1nnc(SCC2CC2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C21 compound treatment 125080.0 -13200.0 -0.51 181200.0 51200.0 1.92 0.996 0.5006 1187470 Maybridge4_004618 NC(=S)c1ccc(nc1)n2cncn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C22 mock treatment 132400.0 -5920.0 -0.23 175360.0 45400.0 1.7 1.0419 0.6063 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C23 mock treatment 130120.0 -8200.0 -0.32 161400.0 31400.0 1.18 0.6088 0.4985 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 C24 mock treatment 138960.0 642.0 0.02 145520.0 15500.0 0.58 0.4299 0.7366 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D01 mock treatment 112200.0 -26100.0 -1.01 146240.0 16300.0 0.61 -0.2851 -0.241 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D02 mock treatment 116080.0 -22200.0 -0.86 161400.0 31400.0 1.18 0.2236 0.1531 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D03 mock treatment 128080.0 -10200.0 -0.4 147440.0 17500.0 0.66 0.1824 0.238 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D04 mock treatment 147160.0 8840.0 0.34 172200.0 42200.0 1.58 1.363 0.8407 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D05 mock treatment 136040.0 -2280.0 -0.09 152960.0 23000.0 0.86 0.5473 0.6313 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D06 mock treatment 147160.0 8840.0 0.34 159680.0 29700.0 1.11 1.0307 0.8838 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D07 mock treatment 128120.0 -10200.0 -0.4 164120.0 34100.0 1.28 0.6262 0.467 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D08 mock treatment 141960.0 3640.0 0.14 163720.0 33700.0 1.27 0.9953 0.7812 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D09 mock treatment 133960.0 -4360.0 -0.17 167000.0 37000.0 1.39 0.8628 0.6165 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D10 mock treatment 146960.0 8640.0 0.34 171960.0 42000.0 1.58 1.3511 0.8388 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D11 mock treatment 140080.0 1760.0 0.07 161360.0 31400.0 1.18 0.881 0.7469 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D12 mock treatment 147640.0 9320.0 0.36 175600.0 45600.0 1.71 1.4664 0.838 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D13 mock treatment 161680.0 23400.0 0.91 168080.0 38100.0 1.43 1.652 0.9758 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D14 mock treatment 135200.0 -3120.0 -0.12 181680.0 51700.0 1.94 1.2864 0.6617 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D15 mock treatment 140240.0 1920.0 0.07 165000.0 35000.0 1.31 0.982 0.746 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D16 mock treatment 126080.0 -12200.0 -0.47 165240.0 35300.0 1.32 0.5999 0.4267 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D17 mock treatment 118920.0 -19400.0 -0.75 163000.0 33000.0 1.24 0.344 0.2373 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D18 mock treatment 126840.0 -11500.0 -0.45 189600.0 59600.0 2.24 1.2673 0.5555 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D19 mock treatment 129560.0 -8760.0 -0.34 172040.0 42100.0 1.58 0.8759 0.5424 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D20 mock treatment 137840.0 -478.0 -0.02 162000.0 32000.0 1.2 0.8366 0.6961 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D21 mock treatment 130520.0 -7800.0 -0.3 165960.0 36000.0 1.35 0.7408 0.5354 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D22 mock treatment 119680.0 -18600.0 -0.72 156200.0 26200.0 0.98 0.1844 0.151 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D23 mock treatment 127240.0 -11100.0 -0.43 133800.0 3820.0 0.14 -0.2026 -0.4472 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 D24 mock treatment 125520.0 -12800.0 -0.5 136880.0 6900.0 0.26 -0.1681 -0.3002 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E01 compound treatment 6280.0 -132000.0 -5.12 16080.0 -114000.0 -4.27 -6.6455 -0.996 3178907 Maybridge4_004619 FC(F)(F)c1cccn(CCC(=O)Sc2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E02 compound treatment 60360.0 -78000.0 -3.02 74440.0 -55500.0 -2.08 -3.6129 -0.9835 1539590 Maybridge4_004620 Oc1ccc2c(CSc3ccccn3)cc(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E03 compound treatment 94560.0 -43800.0 -1.7 110720.0 -19300.0 -0.72 -1.7118 -0.9276 3178908 Maybridge4_004621 NC(=S)c1ccc(nc1)N2CCC(CC2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E04 compound treatment 9920.0 -128000.0 -4.98 11360.0 -119000.0 -4.45 -6.6709 -0.9984 3178909 Maybridge4_004622 Cc1cccc(Cl)c1OC(=O)c2cc(nn2C)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E05 compound treatment 130760.0 -7560.0 -0.29 146800.0 16800.0 0.63 0.2389 0.3433 3065784 Maybridge4_004623 OC(=O)CCn1cc(ccc1=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E06 compound treatment 11120.0 -127000.0 -4.94 12000.0 -118000.0 -4.43 -6.6209 -0.9985 1605604 Maybridge4_004624 Cc1cc(C(=O)Sc2ccccc2)n(Cc3ccc(C)cc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E07 compound treatment 114280.0 -24000.0 -0.93 128240.0 -1740.0 -0.07 -0.7058 -0.7548 3065785 Maybridge4_004625 FC(F)(F)c1cccn(Cc2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E08 compound treatment 75520.0 -62800.0 -2.44 86920.0 -43100.0 -1.62 -2.8658 -0.9801 3178983 Maybridge4_004626 O=c1[nH]nc(SCc2ccccc2)n1c3ccc(OCc4ccccc4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E09 compound treatment 121400.0 -16900.0 -0.66 133600.0 3620.0 0.14 -0.3682 -0.5492 3065786 Maybridge4_004627 Cn1c(S)nnc1Cn2cc(ccc2=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E10 compound treatment 15680.0 -123000.0 -4.76 47200.0 -82800.0 -3.11 -5.5617 -0.9787 3178984 Maybridge4_004628 CC(=O)N/C(=C/c1ccc(Cl)c(Cl)c1)/C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E11 compound treatment 86360.0 -52000.0 -2.02 106920.0 -23100.0 -0.87 -2.0376 -0.9287 3065787 Maybridge4_004629 Cn1c(SCc2ccc(cc2)C(F)(F)F)nnc1c3ccc(OCC(F)(F)F)nc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E12 compound treatment 136480.0 -1840.0 -0.07 138400.0 8420.0 0.32 0.1729 0.534 3178985 Maybridge4_004630 Clc1ccc(cc1)c2nnc(SCC3CC3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E13 compound treatment 132480.0 -5840.0 -0.23 131520.0 1540.0 0.06 -0.1194 -0.5107 3178986 Maybridge4_004631 Cc1ccccc1NC(=O)c2cccc(Cn3cc(ccc3=O)C(F)(F)F)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E14 compound treatment 88840.0 -49500.0 -1.92 117360.0 -12600.0 -0.47 -1.6925 -0.8559 1516971 Maybridge4_004632 Cc1ccc(cc1)C(=O)CSc2nnc(o2)c3cc(nn3Cc4cccc(C)c4)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E15 compound treatment 119480.0 -18800.0 -0.73 131960.0 1980.0 0.07 -0.4644 -0.6321 3178987 Maybridge4_004633 NNC(=N)c1ccc(cn1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E16 compound treatment 132840.0 -5480.0 -0.21 136280.0 6300.0 0.24 0.0168 0.0529 3065788 Maybridge4_004634 CC(C)N(CCC#N)CN1C(=O)c2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E17 compound treatment 12600.0 -126000.0 -4.88 16000.0 -114000.0 -4.28 -6.4742 -0.9979 3065812 Maybridge4_004635 CC(C)c1ccc(NC(=O)CSC2=NNC(S2)c3ccccn3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E18 compound treatment 87520.0 -50800.0 -1.97 102240.0 -27700.0 -1.04 -2.13 -0.9555 3065813 Maybridge4_004636 Clc1ccc(N/C(=N\C#N)/Oc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E19 compound treatment 80120.0 -58200.0 -2.26 104000.0 -26000.0 -0.98 -2.2863 -0.9295 1232015 Maybridge4_004637 Sc1nc2CCCCc2c(c3cccs3)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E20 compound treatment 107360.0 -31000.0 -1.2 119120.0 -10900.0 -0.41 -1.1377 -0.8969 3065814 Maybridge4_004638 CC(Sc1ccc(C)cc1)C(=O)c2ccc(C)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E21 compound treatment 10400.0 -128000.0 -4.96 15760.0 -114000.0 -4.29 -6.5409 -0.9973 3065815 Maybridge4_004639 CCOC(=O)c1nc(C)nc(Sc2nnc([nH]2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E22 mock treatment 117440.0 -20900.0 -0.81 141440.0 11500.0 0.43 -0.2688 -0.293 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E23 mock treatment 125800.0 -12500.0 -0.49 120080.0 -9900.0 -0.37 -0.6063 -0.9913 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 E24 mock treatment 104720.0 -33600.0 -1.3 122440.0 -7540.0 -0.28 -1.122 -0.8411 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F01 mock treatment 110680.0 -27600.0 -1.07 143960.0 14000.0 0.52 -0.3873 -0.3245 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F02 mock treatment 131400.0 -6920.0 -0.27 150800.0 20800.0 0.78 0.3627 0.439 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F03 mock treatment 118760.0 -19600.0 -0.76 135200.0 5220.0 0.2 -0.3981 -0.508 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F04 mock treatment 156920.0 18600.0 0.72 146600.0 16600.0 0.62 0.9514 0.9974 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F05 mock treatment 140320.0 2000.0 0.08 144720.0 14700.0 0.55 0.446 0.7986 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F06 mock treatment 154040.0 15700.0 0.61 153160.0 23200.0 0.87 1.0464 0.9849 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F07 mock treatment 132360.0 -5960.0 -0.23 144600.0 14600.0 0.55 0.2245 0.377 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F08 mock treatment 146200.0 7880.0 0.31 140680.0 10700.0 0.4 0.5001 0.991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F09 mock treatment 150480.0 12200.0 0.47 144640.0 14700.0 0.55 0.7227 0.9971 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F10 mock treatment 145960.0 7640.0 0.3 147080.0 17100.0 0.64 0.6634 0.9385 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F11 mock treatment 143400.0 5080.0 0.2 155600.0 25600.0 0.96 0.8193 0.8347 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F12 mock treatment 148000.0 9680.0 0.38 147000.0 17000.0 0.64 0.7172 0.968 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F13 mock treatment 142880.0 4560.0 0.18 137600.0 7620.0 0.29 0.3273 0.9734 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F14 mock treatment 135520.0 -2800.0 -0.11 144640.0 14700.0 0.55 0.3122 0.5568 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F15 mock treatment 141560.0 3240.0 0.13 150480.0 20500.0 0.77 0.6329 0.8119 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F16 mock treatment 125280.0 -13000.0 -0.51 134080.0 4100.0 0.15 -0.249 -0.4709 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F17 mock treatment 125560.0 -12800.0 -0.5 144520.0 14500.0 0.55 0.0358 0.0485 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F18 mock treatment 132520.0 -5800.0 -0.22 140560.0 10600.0 0.4 0.1216 0.2665 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F19 mock treatment 150480.0 12200.0 0.47 152640.0 22700.0 0.85 0.935 0.9614 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F20 mock treatment 138080.0 -238.0 -0.01 151520.0 21500.0 0.81 0.565 0.699 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F21 mock treatment 149520.0 11200.0 0.43 137920.0 7940.0 0.3 0.518 0.983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F22 mock treatment 129240.0 -9080.0 -0.35 145160.0 15200.0 0.57 0.1537 0.2295 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F23 mock treatment 129160.0 -9160.0 -0.36 128480.0 -1500.0 -0.06 -0.2912 -0.8092 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 F24 mock treatment 111280.0 -27000.0 -1.05 113960.0 -16000.0 -0.6 -1.1671 -0.9651 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G01 compound treatment 108400.0 -29900.0 -1.16 111160.0 -18800.0 -0.71 -1.3204 -0.9716 3065816 Maybridge4_004640 Cc1nc(N)nc(CSc2ccccc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G02 compound treatment 46120.0 -92200.0 -3.58 61040.0 -68900.0 -2.59 -4.3592 -0.9874 3065817 Maybridge4_004641 Oc1ccc2c(CSc3nnc([nH]3)c4cccs4)cc(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G03 compound treatment 90440.0 -47900.0 -1.86 93520.0 -36500.0 -1.37 -2.2813 -0.9887 1387671 Maybridge4_004642 CN(CCOC(=O)Nc1cccc(Cl)c1)c2ccc(C#N)cn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G04 compound treatment 10800.0 -128000.0 -4.95 11360.0 -119000.0 -4.45 -6.6467 -0.9986 1420583 Maybridge4_004643 Clc1ccc(CSc2n[nH]c(=O)n2C3CC4CC3C=C4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G05 compound treatment 129680.0 -8640.0 -0.34 131120.0 1140.0 0.04 -0.2068 -0.6121 3178988 Maybridge4_004644 COC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G06 compound treatment 12600.0 -126000.0 -4.88 13720.0 -116000.0 -4.36 -6.5347 -0.9985 3065818 Maybridge4_004645 Cc1cc(nn1Cc2ccc(C)cc2)C(=O)Sc3cccc(Cl)c3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G07 compound treatment 122680.0 -15600.0 -0.61 124280.0 -5700.0 -0.21 -0.5804 -0.9021 3178989 Maybridge4_004646 FC(F)(F)c1cccn(CC(=O)c2ccc(Cl)cc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G08 compound treatment 11400.0 -127000.0 -4.92 12520.0 -117000.0 -4.41 -6.5995 -0.9985 1219573 Maybridge4_004647 CC(C)(C)c1cc(NC(=O)CSc2n[nH]c(=O)n2c3ccc4OCCOc4c3)cc(c1)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G09 compound treatment 123200.0 -15100.0 -0.59 110720.0 -19300.0 -0.72 -0.926 -0.9946 3065819 Maybridge4_004648 CCOC(=O)c1cnc(nc1Sc2nnc([nH]2)c3cccs3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G10 compound treatment 133640.0 -4680.0 -0.18 141680.0 11700.0 0.44 0.1821 0.3833 1396971 Maybridge4_004649 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c2nnc(S)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G11 compound treatment 12240.0 -126000.0 -4.89 12960.0 -117000.0 -4.39 -6.5647 -0.9986 3065820 Maybridge4_004650 CCOC(=O)c1cc(C#N)c(Sc2ccccc2NC(=O)c3ccccc3)nc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G12 compound treatment 36640.0 -102000.0 -3.95 43480.0 -86500.0 -3.25 -5.0853 -0.9953 1227698 Maybridge4_004651 Cc1cccc(Cn2nc(cc2C(=O)Nc3cccnc3)C(C)(C)C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G13 compound treatment 25120.0 -113000.0 -4.39 25160.0 -105000.0 -3.93 -5.8876 -0.9985 3065822 Maybridge4_004652 FC(F)(F)c1ccc(=O)n(Cc2cccc(c2)C(=O)Sc3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G14 compound treatment 134040.0 -4280.0 -0.17 129720.0 -263.0 -0.01 -0.1244 -0.7478 3178991 Maybridge4_004653 CCOC(=O)C1CCN(CC1)c2nc(c(cc2C#N)C(=O)OCC)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G15 compound treatment 117040.0 -21300.0 -0.83 124080.0 -5900.0 -0.22 -0.7404 -0.8662 1653461 Maybridge4_004654 CC(=O)N1CCN(CC1)c2nc3ccc(Cl)cc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G16 compound treatment 139600.0 1280.0 0.05 135080.0 5100.0 0.19 0.1704 0.8623 3178992 Maybridge4_004655 CC(C)N(CCC#N)C(=S)Nc1c(C)cccc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G17 compound treatment 124040.0 -14300.0 -0.55 140760.0 10800.0 0.4 -0.1057 -0.1541 3065823 Maybridge4_004656 COC(=N)NC(=S)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G18 compound treatment 107400.0 -30900.0 -1.2 120360.0 -9620.0 -0.36 -1.1037 -0.8809 1122990 Maybridge4_004657 CC(C)NC(=O)Nc1nc(Nc2ccc(Cl)cc2)n[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G19 compound treatment 130640.0 -7680.0 -0.3 135360.0 5380.0 0.2 -0.068 -0.1889 3178993 Maybridge4_004658 N1N=C(NC1c2cccnc2)c3cnccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G20 compound treatment 113800.0 -24500.0 -0.95 124520.0 -5460.0 -0.21 -0.8177 -0.8402 1235857 Maybridge4_004659 Cc1c(C#N)c(=N)n(nc1C(=O)Nc2ccccc2)c3ccc(cc3)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G21 compound treatment 118160.0 -20200.0 -0.78 128720.0 -1260.0 -0.05 -0.5866 -0.7486 3178994 Maybridge4_004660 CCOC(=O)c1sc2nc(c(cc2c1NC(=O)C)C(=O)OCC)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G22 mock treatment 142840.0 4520.0 0.18 140480.0 10500.0 0.39 0.4026 0.9336 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G23 mock treatment 139280.0 962.0 0.04 126360.0 -3620.0 -0.14 -0.0698 -0.4948 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 G24 mock treatment 112840.0 -25500.0 -0.99 119280.0 -10700.0 -0.4 -0.9831 -0.9213 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H01 mock treatment 120360.0 -18000.0 -0.7 112720.0 -17300.0 -0.65 -0.9508 -0.9993 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H02 mock treatment 121040.0 -17300.0 -0.67 143480.0 13500.0 0.51 -0.1158 -0.1379 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H03 mock treatment 137600.0 -718.0 -0.03 136760.0 6780.0 0.25 0.1601 0.6259 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H04 mock treatment 147960.0 9640.0 0.37 141560.0 11600.0 0.43 0.5718 0.9972 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H05 mock treatment 154000.0 15700.0 0.61 151080.0 21100.0 0.79 0.9901 0.9915 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H06 mock treatment 154440.0 16100.0 0.63 148160.0 18200.0 0.68 0.9247 0.9991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H07 mock treatment 151200.0 12900.0 0.5 142200.0 12200.0 0.46 0.6776 0.9991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H08 mock treatment 151760.0 13400.0 0.52 151880.0 21900.0 0.82 0.9499 0.9759 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H09 mock treatment 144280.0 5960.0 0.23 138720.0 8740.0 0.33 0.3954 0.9854 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H10 mock treatment 162240.0 23900.0 0.93 140200.0 10200.0 0.38 0.9275 0.9235 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H11 mock treatment 147400.0 9080.0 0.35 145680.0 15700.0 0.59 0.6657 0.9698 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H12 mock treatment 150040.0 11700.0 0.45 138560.0 8580.0 0.32 0.5492 0.9857 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H13 mock treatment 149000.0 10700.0 0.41 139280.0 9300.0 0.35 0.5398 0.9963 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H14 mock treatment 147720.0 9400.0 0.36 147280.0 17300.0 0.65 0.717 0.9628 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H15 mock treatment 144520.0 6200.0 0.24 142080.0 12100.0 0.45 0.4912 0.9559 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H16 mock treatment 153440.0 15100.0 0.59 146000.0 16000.0 0.6 0.84 0.9999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H17 mock treatment 139240.0 922.0 0.04 141440.0 11500.0 0.43 0.3293 0.7633 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H18 mock treatment 147120.0 8800.0 0.34 142000.0 12000.0 0.45 0.5604 0.9906 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H19 mock treatment 145640.0 7320.0 0.28 148880.0 18900.0 0.71 0.7024 0.9193 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H20 mock treatment 139440.0 1120.0 0.04 134920.0 4940.0 0.19 0.1618 0.8501 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H21 mock treatment 142040.0 3720.0 0.14 134040.0 4060.0 0.15 0.2098 0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H22 mock treatment 128480.0 -9840.0 -0.38 123920.0 -6060.0 -0.23 -0.4308 -0.9694 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H23 mock treatment 128560.0 -9760.0 -0.38 140560.0 10600.0 0.4 0.013 0.0237 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 H24 mock treatment 108840.0 -29500.0 -1.14 116880.0 -13100.0 -0.49 -1.1565 -0.9289 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I01 compound treatment 111360.0 -27000.0 -1.05 104080.0 -25900.0 -0.97 -1.4271 -0.9993 3178995 Maybridge4_004661 FC(F)(F)COc1ccc(cn1)C(=O)NC(=O)NN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I02 compound treatment 121840.0 -16500.0 -0.64 108680.0 -21300.0 -0.8 -1.0175 -0.9939 3065824 Maybridge4_004662 Oc1nnc(SCc2cc(=O)oc3cc(O)ccc23)n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I03 compound treatment 10200.0 -128000.0 -4.97 9240.0 -121000.0 -4.53 -6.7194 -0.9989 3178996 Maybridge4_004663 Cc1noc(COc2ccccc2)c1C(=O)Sc3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I04 compound treatment 124320.0 -14000.0 -0.54 131800.0 1820.0 0.07 -0.3358 -0.6135 3065825 Maybridge4_004664 Cc1c(C#N)c(Sc2ccccc2Cl)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I05 compound treatment 119800.0 -18500.0 -0.72 127560.0 -2420.0 -0.09 -0.5724 -0.7903 3178997 Maybridge4_004665 COC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)Nc3ccc(Cl)cc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I06 compound treatment 98160.0 -40200.0 -1.56 95960.0 -34000.0 -1.28 -2.0047 -0.9951 1622413 Maybridge4_004666 COc1ccc(SC(=O)c2cc(C)n(Cc3c(Cl)cccc3Cl)n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I07 compound treatment 131000.0 -7320.0 -0.28 119480.0 -10500.0 -0.39 -0.4795 -0.987 3178998 Maybridge4_004667 FC(F)(F)c1ccc(=O)n(CC(=O)c2ccc(C#N)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I08 compound treatment 137880.0 -438.0 -0.02 121400.0 -8580.0 -0.32 -0.2398 -0.7434 3065827 Maybridge4_004668 CSc1n[nH]c(=O)n1c2ccc3OCCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I09 compound treatment 14120.0 -124000.0 -4.82 12640.0 -117000.0 -4.4 -6.5217 -0.999 3065847 Maybridge4_004669 CCOC(=O)c1cc(C#N)c(Sc2n[nH]c(=O)n2Cc3ccc(cc3)C(F)(F)F)nc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I10 compound treatment 139320.0 1000.0 0.04 122640.0 -7340.0 -0.28 -0.1674 -0.6014 3065848 Maybridge4_004670 CC(C)(C)NC(=O)[C@H]1C[C@H]2CCCC[C@H]2CN1C(=O)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I11 compound treatment 134880.0 -3440.0 -0.13 127800.0 -2180.0 -0.08 -0.1523 -0.9726 3065849 Maybridge4_004671 FC(F)(F)c1ccc(nc1)C(=N)NC(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I12 compound treatment 138920.0 602.0 0.02 131960.0 1980.0 0.07 0.069 0.8867 1418931 Maybridge4_004672 Cc1cc(C)c(Cn2nc(cc2C(=O)NN3CCOCC3)C(C)(C)C)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I13 compound treatment 67120.0 -71200.0 -2.76 80360.0 -49600.0 -1.86 -3.2703 -0.9816 3065850 Maybridge4_004673 FC(F)(F)c1ccc(=O)n(Cc2cccc(c2)C(=O)NC(=N)c3ccc(Cl)cc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I14 compound treatment 137120.0 -1200.0 -0.05 127840.0 -2140.0 -0.08 -0.0897 -0.9661 1208016 Maybridge4_004674 COC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I15 compound treatment 126920.0 -11400.0 -0.44 113040.0 -16900.0 -0.64 -0.7624 -0.9843 1224162 Maybridge4_004675 CC(C)(C)C(=O)N1CCN(CC1)c2nc3ccc(Cl)cc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I16 compound treatment 104160.0 -34200.0 -1.33 103520.0 -26500.0 -0.99 -1.6395 -0.9899 3065852 Maybridge4_004676 CCN(C(=S)Nc1ccc(C)cc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I17 compound treatment 12880.0 -125000.0 -4.87 11920.0 -118000.0 -4.43 -6.5748 -0.9989 3178999 Maybridge4_004677 Clc1ccc(cc1)c2nnc(Sc3nc(ns3)c4cccs4)[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I18 compound treatment 111320.0 -27000.0 -1.05 112080.0 -17900.0 -0.67 -1.2158 -0.977 3065853 Maybridge4_004678 CCCNC(=O)Nc1nc(Nc2ccc(Cl)cc2)n[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I19 compound treatment 143240.0 4920.0 0.19 135240.0 5260.0 0.2 0.2745 0.9999 3179000 Maybridge4_004679 FC(F)(F)c1ccncc1C(=O)NC(=N)c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I20 compound treatment 62280.0 -76000.0 -2.95 79840.0 -50100.0 -1.88 -3.4169 -0.9764 3179001 Maybridge4_004680 CC(Sc1ccc(C)cc1)C(=O)Nc2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I21 compound treatment 47720.0 -90600.0 -3.52 46400.0 -83600.0 -3.14 -4.7039 -0.9984 3065854 Maybridge4_004681 Sc1nnc(s1)c2cnccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I22 mock treatment 135520.0 -2800.0 -0.11 128400.0 -1580.0 -0.06 -0.1188 -0.9597 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I23 mock treatment 145560.0 7240.0 0.28 119680.0 -10300.0 -0.39 -0.0747 -0.1564 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 I24 mock treatment 107160.0 -31200.0 -1.21 117600.0 -12400.0 -0.46 -1.1835 -0.9137 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J01 mock treatment 130560.0 -7760.0 -0.3 123280.0 -6700.0 -0.25 -0.3907 -0.996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J02 mock treatment 126440.0 -11900.0 -0.46 134160.0 4180.0 0.16 -0.215 -0.4417 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J03 mock treatment 136840.0 -1480.0 -0.06 123000.0 -6980.0 -0.26 -0.2259 -0.8419 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J04 mock treatment 152920.0 14600.0 0.57 133560.0 3580.0 0.13 0.4955 0.8511 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J05 mock treatment 151880.0 13600.0 0.53 136160.0 6180.0 0.23 0.536 0.9322 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J06 mock treatment 151440.0 13100.0 0.51 138400.0 8420.0 0.32 0.5834 0.9737 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J07 mock treatment 152840.0 14500.0 0.56 137560.0 7580.0 0.28 0.5995 0.9499 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J08 mock treatment 151880.0 13600.0 0.53 148760.0 18800.0 0.7 0.8704 0.9896 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J09 mock treatment 159400.0 21100.0 0.82 125680.0 -4300.0 -0.16 0.4642 0.5568 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J10 mock treatment 151680.0 13400.0 0.52 135840.0 5860.0 0.22 0.522 0.927 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J11 mock treatment 168680.0 30400.0 1.18 146400.0 16400.0 0.62 1.2687 0.9543 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J12 mock treatment 146800.0 8480.0 0.33 147040.0 17100.0 0.64 0.6854 0.9522 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J13 mock treatment 149480.0 11200.0 0.43 139840.0 9860.0 0.37 0.5678 0.9969 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J14 mock treatment 149720.0 11400.0 0.44 141160.0 11200.0 0.42 0.6094 0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J15 mock treatment 147000.0 8680.0 0.34 141720.0 11700.0 0.44 0.5497 0.9912 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J16 mock treatment 148240.0 9920.0 0.38 124800.0 -5180.0 -0.19 0.1347 0.3122 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J17 mock treatment 141640.0 3320.0 0.13 124440.0 -5540.0 -0.21 -0.056 -0.2287 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J18 mock treatment 136760.0 -1560.0 -0.06 135200.0 5220.0 0.2 0.0957 0.467 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J19 mock treatment 139440.0 1120.0 0.04 135680.0 5700.0 0.21 0.182 0.8339 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J20 mock treatment 163320.0 25000.0 0.97 133440.0 3460.0 0.13 0.7777 0.7946 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J21 mock treatment 144120.0 5800.0 0.23 122840.0 -7140.0 -0.27 -0.0304 -0.0868 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J22 mock treatment 130680.0 -7640.0 -0.3 125360.0 -4620.0 -0.17 -0.3323 -0.9675 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J23 mock treatment 123080.0 -15200.0 -0.59 114160.0 -15800.0 -0.59 -0.838 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 J24 mock treatment 117960.0 -20400.0 -0.79 115720.0 -14300.0 -0.54 -0.9371 -0.982 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K01 compound treatment 89520.0 -48800.0 -1.89 60880.0 -69100.0 -2.59 -3.1727 -0.988 3065855 Maybridge4_004682 Oc1c/c(=N\c2ccc(Cl)cc2)/nc(COc3ccccc3)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K02 compound treatment 7880.0 -130000.0 -5.06 6680.0 -123000.0 -4.63 -6.851 -0.999 3179002 Maybridge4_004683 Cc1cc(nn1C(C)(C)C)C(=O)Sc2cccc(c2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K03 compound treatment 10080.0 -128000.0 -4.98 8280.0 -122000.0 -4.57 -6.7482 -0.9991 3179003 Maybridge4_004684 Cc1noc(COc2ccccc2)c1C(=O)Sc3ccc(F)cc3F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K04 compound treatment 135160.0 -3160.0 -0.12 126840.0 -3140.0 -0.12 -0.1701 -0.9998 3065857 Maybridge4_004685 Cc1c(C#N)c(Sc2cccc(c2)C(F)(F)F)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K05 compound treatment 92480.0 -45800.0 -1.78 80840.0 -49100.0 -1.84 -2.5618 -0.9998 3179004 Maybridge4_004686 CSc1nc(CSc2ccc(Cl)cc2)nc(C3CC3)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K06 compound treatment 114000.0 -24300.0 -0.94 98520.0 -31500.0 -1.18 -1.5022 -0.9938 3065858 Maybridge4_004687 Cc1cc(nn1Cc2c(Cl)cccc2Cl)C(=O)SCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K07 compound treatment 95080.0 -43200.0 -1.68 78560.0 -51400.0 -1.93 -2.551 -0.9976 3179005 Maybridge4_004688 CCOC(=O)c1cc(C#N)c(Oc2ccc(C)cc2)nc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K08 compound treatment 12320.0 -126000.0 -4.89 9640.0 -120000.0 -4.52 -6.6507 -0.9992 3065859 Maybridge4_004689 CC(C)OC(=O)Nc1cc(Cl)cc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K09 compound treatment 63400.0 -74900.0 -2.91 44280.0 -85700.0 -3.22 -4.3299 -0.9987 3179006 Maybridge4_004690 FC(F)(F)C1CCN(CC1)c2ncccc2NC(=S)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K10 compound treatment 122880.0 -15400.0 -0.6 106360.0 -23600.0 -0.89 -1.0505 -0.9818 1235731 Maybridge4_004691 S=C(NC1CCCC1)N2CCCN(CC2)c3ccc(C#N)cn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K11 compound treatment 133240.0 -5080.0 -0.2 113480.0 -16500.0 -0.62 -0.5773 -0.8882 3179007 Maybridge4_004692 FC(F)(F)c1ccc(nc1)C(=N)NC(=O)c2cccc(c2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K12 compound treatment 68400.0 -69900.0 -2.71 57800.0 -72200.0 -2.71 -3.8339 -1.0 1285775 Maybridge4_004693 Cc1onc(c1c2csc(CCn3c(=O)oc4ccccc34)n2)c5c(Cl)cccc5Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K13 compound treatment 142040.0 3720.0 0.14 128040.0 -1940.0 -0.07 0.0505 0.3124 3065861 Maybridge4_004694 NNC(=O)c1cccc(n1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K14 compound treatment 135120.0 -3200.0 -0.12 125560.0 -4420.0 -0.17 -0.2051 -0.9897 3179092 Maybridge4_004695 CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCN3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K15 compound treatment 111480.0 -26800.0 -1.04 92880.0 -37100.0 -1.39 -1.721 -0.9897 3065862 Maybridge4_004696 FC(F)(F)c1ccc(nc1)c2nnc(S)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K16 compound treatment 124960.0 -13400.0 -0.52 105600.0 -24400.0 -0.92 -1.0136 -0.9638 3065863 Maybridge4_004697 CC(C)N(CCC#N)C(=S)Nc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K17 compound treatment 133040.0 -5280.0 -0.2 109200.0 -20800.0 -0.78 -0.6964 -0.8635 3179093 Maybridge4_004698 CC(C)C(=N)NC(=S)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K18 compound treatment 135120.0 -3200.0 -0.12 123480.0 -6500.0 -0.24 -0.2603 -0.9508 1330597 Maybridge4_004699 CS(=O)(=O)c1ccc(cc1)C(=O)Nc2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K19 compound treatment 146920.0 8600.0 0.33 137400.0 7420.0 0.28 0.4328 0.9959 3179094 Maybridge4_004700 N=C(NC(=O)N1CCOCC1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K20 compound treatment 139920.0 1600.0 0.06 118000.0 -12000.0 -0.45 -0.2741 -0.6037 3065864 Maybridge4_004701 CN(C)/C=N/c1ncc(Br)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K21 compound treatment 123120.0 -15200.0 -0.59 128840.0 -1140.0 -0.04 -0.4473 -0.7565 3179095 Maybridge4_004702 CC(C)(C)C(=O)CSc1nnc(s1)c2cnccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K22 mock treatment 139720.0 1400.0 0.05 109960.0 -20000.0 -0.75 -0.4929 -0.6542 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K23 mock treatment 122960.0 -15400.0 -0.6 119440.0 -10500.0 -0.4 -0.7012 -0.9802 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 K24 mock treatment 128240.0 -10100.0 -0.39 99480.0 -30500.0 -1.14 -1.086 -0.8977 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L01 mock treatment 124760.0 -13600.0 -0.53 91880.0 -38100.0 -1.43 -1.3832 -0.9078 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L02 mock treatment 127800.0 -10500.0 -0.41 117680.0 -12300.0 -0.46 -0.6151 -0.9981 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L03 mock treatment 148120.0 9800.0 0.38 119440.0 -10500.0 -0.4 -0.0109 -0.0198 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L04 mock treatment 144520.0 6200.0 0.24 120400.0 -9580.0 -0.36 -0.0842 -0.1945 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L05 mock treatment 143480.0 5160.0 0.2 130120.0 137.0 0.01 0.1453 0.725 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L06 mock treatment 153600.0 15300.0 0.59 129320.0 -663.0 -0.02 0.4017 0.6768 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L07 mock treatment 147560.0 9240.0 0.36 126960.0 -3020.0 -0.11 0.1733 0.4609 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L08 mock treatment 151800.0 13500.0 0.52 127160.0 -2820.0 -0.11 0.295 0.5527 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L09 mock treatment 146160.0 7840.0 0.3 128640.0 -1340.0 -0.05 0.1795 0.582 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L10 mock treatment 149520.0 11200.0 0.43 131280.0 1300.0 0.05 0.3418 0.7814 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L11 mock treatment 148520.0 10200.0 0.4 123320.0 -6660.0 -0.25 0.1031 0.2201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L12 mock treatment 158600.0 20300.0 0.79 146680.0 16700.0 0.63 0.9996 0.9936 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L13 mock treatment 145640.0 7320.0 0.28 138280.0 8300.0 0.31 0.4211 0.9989 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L14 mock treatment 153960.0 15600.0 0.61 139080.0 9100.0 0.34 0.6706 0.963 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L15 mock treatment 149040.0 10700.0 0.42 119480.0 -10500.0 -0.39 0.0154 0.0269 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L16 mock treatment 154840.0 16500.0 0.64 116160.0 -13800.0 -0.52 0.0864 0.1048 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L17 mock treatment 154160.0 15800.0 0.61 118360.0 -11600.0 -0.44 0.1262 0.1674 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L18 mock treatment 145400.0 7080.0 0.27 119280.0 -10700.0 -0.4 -0.0898 -0.1844 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L19 mock treatment 171320.0 33000.0 1.28 136080.0 6100.0 0.23 1.0672 0.8205 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L20 mock treatment 149680.0 11400.0 0.44 117880.0 -12100.0 -0.45 -0.0095 -0.015 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L21 mock treatment 135520.0 -2800.0 -0.11 128240.0 -1740.0 -0.07 -0.123 -0.9706 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L22 mock treatment 132000.0 -6320.0 -0.25 110840.0 -19100.0 -0.72 -0.6814 -0.8976 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L23 mock treatment 121680.0 -16600.0 -0.65 102760.0 -27200.0 -1.02 -1.179 -0.9755 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 L24 mock treatment 125640.0 -12700.0 -0.49 107880.0 -22100.0 -0.83 -0.9344 -0.9689 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M01 compound treatment 101120.0 -37200.0 -1.44 59320.0 -70700.0 -2.65 -2.8959 -0.9591 3065865 Maybridge4_004703 FC(F)(F)c1cccn(CCc2nc(cs2)c3ccccc3)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M02 compound treatment 9600.0 -129000.0 -4.99 7200.0 -123000.0 -4.61 -6.79 -0.9992 3179096 Maybridge4_004704 Cc1cc(nn1C(C)(C)C)C(=O)Sc2cccc(Br)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M03 compound treatment 90440.0 -47900.0 -1.86 100560.0 -29400.0 -1.1 -2.0944 -0.9691 3179097 Maybridge4_004705 CN(CCOC(=O)c1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M04 compound treatment 88560.0 -49800.0 -1.93 84800.0 -45200.0 -1.7 -2.5643 -0.9979 3065866 Maybridge4_004706 Cc1c(C#N)c(Sc2n[nH]c(=O)n2C3CCCCC3)nc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M05 compound treatment 116920.0 -21400.0 -0.83 107840.0 -22100.0 -0.83 -1.1747 -1.0 3065894 Maybridge4_004707 CCOC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)c3cccc(c3)C(F)(F)F)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M06 compound treatment 132240.0 -6080.0 -0.24 114680.0 -15300.0 -0.57 -0.5729 -0.9227 3065895 Maybridge4_004708 OC(C(O)c1nc2cc(C#N)ccc2[nH]1)c3nc4cc(C#N)ccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M07 compound treatment 103440.0 -34900.0 -1.35 66800.0 -63200.0 -2.37 -2.6337 -0.9646 3065896 Maybridge4_004709 CCOC(=O)c1cc(C#N)c(Sc2nnc([nH]2)C(C)(C)C)nc1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M08 compound treatment 131360.0 -6960.0 -0.27 86920.0 -43100.0 -1.62 -1.3338 -0.8139 3065897 Maybridge4_004710 NC(=S)Cc1ccc(Cl)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M09 compound treatment 14560.0 -124000.0 -4.8 11200.0 -119000.0 -4.46 -6.5478 -0.9993 3065898 Maybridge4_004711 FC(F)(F)C1CCN(CC1)c2ncccc2NC(=S)Nc3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M10 compound treatment 136040.0 -2280.0 -0.09 100040.0 -29900.0 -1.12 -0.8572 -0.7604 1643927 Maybridge4_004712 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c2nnc(S)n2CC3CCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M11 compound treatment 134720.0 -3600.0 -0.14 106360.0 -23600.0 -0.89 -0.7257 -0.8085 3065900 Maybridge4_004713 FC(F)(F)c1ccc(=O)n(Cc2cccc(C#N)c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M12 compound treatment 110120.0 -28200.0 -1.09 101840.0 -28100.0 -1.06 -1.5205 -0.9998 1263587 Maybridge4_004714 COc1ccccc1OCc2nc(cs2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M13 compound treatment 129680.0 -8640.0 -0.34 113960.0 -16000.0 -0.6 -0.6622 -0.9619 3179098 Maybridge4_004715 FC(F)(F)c1ccc(cc1)C(=N)NC(=O)CCn2c(=O)oc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M14 compound treatment 137080.0 -1240.0 -0.05 122640.0 -7340.0 -0.28 -0.2288 -0.818 1136340 Maybridge4_004716 CCOc1cc(N2CCOCC2)c(OCC)cc1NS(=O)(=O)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M15 compound treatment 135440.0 -2880.0 -0.11 113800.0 -16200.0 -0.61 -0.5084 -0.8233 3179099 Maybridge4_004717 FC(F)(F)c1ccc(nc1)c2nnc(SCC=C)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M16 compound treatment 136160.0 -2160.0 -0.08 106880.0 -23100.0 -0.87 -0.6723 -0.7718 1122167 Maybridge4_004718 O=C(N1CCN(CCOc2ccccc2)CC1)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M17 compound treatment 27480.0 -111000.0 -4.3 8880.0 -121000.0 -4.55 -6.2549 -0.9996 3179100 Maybridge4_004719 FC(F)(F)COc1ccc(cn1)C(=O)NC(=N)c2ccc(cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M18 compound treatment 126680.0 -11600.0 -0.45 100320.0 -29700.0 -1.11 -1.1065 -0.921 3065901 Maybridge4_004720 CNC(=O)Nc1nc2cccnc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M19 compound treatment 134320.0 -4000.0 -0.16 109640.0 -20300.0 -0.76 -0.6496 -0.8337 1030287 Maybridge4_004721 CSc1nc(O)cc(O)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M20 compound treatment 52720.0 -85600.0 -3.32 39800.0 -90200.0 -3.38 -4.7418 -1.0 3179101 Maybridge4_004722 Cc1nc(N/C=N/O)c(Br)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M21 compound treatment 19120.0 -119000.0 -4.62 15320.0 -115000.0 -4.3 -6.3133 -0.9994 3179102 Maybridge4_004723 Cc1nc(c(s1)C(=O)Sc2ccc(C)cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M22 mock treatment 147080.0 8760.0 0.34 110520.0 -19500.0 -0.73 -0.2761 -0.3427 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M23 mock treatment 124320.0 -14000.0 -0.54 113320.0 -16700.0 -0.63 -0.8263 -0.9975 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 M24 mock treatment 114560.0 -23800.0 -0.92 106480.0 -23500.0 -0.88 -1.2756 -0.9998 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N01 mock treatment 137760.0 -558.0 -0.02 131800.0 1820.0 0.07 0.0329 0.4599 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N02 mock treatment 151600.0 13300.0 0.52 99520.0 -30500.0 -1.14 -0.4441 -0.3541 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N03 mock treatment 140600.0 2280.0 0.09 110360.0 -19600.0 -0.74 -0.4582 -0.6177 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N04 mock treatment 136080.0 -2240.0 -0.09 109360.0 -20600.0 -0.77 -0.6087 -0.7815 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N05 mock treatment 151640.0 13300.0 0.52 109800.0 -20200.0 -0.76 -0.1701 -0.1855 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N06 mock treatment 137400.0 -918.0 -0.04 110800.0 -19200.0 -0.72 -0.5343 -0.7412 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N07 mock treatment 135880.0 -2440.0 -0.09 99920.0 -30100.0 -1.13 -0.8647 -0.7637 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N08 mock treatment 142080.0 3760.0 0.15 108720.0 -21300.0 -0.8 -0.4611 -0.5684 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N09 mock treatment 140600.0 2280.0 0.09 107440.0 -22500.0 -0.85 -0.5357 -0.6297 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N10 mock treatment 139960.0 1640.0 0.06 126520.0 -3460.0 -0.13 -0.0469 -0.3238 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N11 mock treatment 141560.0 3240.0 0.13 122880.0 -7100.0 -0.27 -0.0996 -0.3378 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N12 mock treatment 154440.0 16100.0 0.63 128880.0 -1100.0 -0.04 0.413 0.6589 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N13 mock treatment 146280.0 7960.0 0.31 137320.0 7340.0 0.28 0.4132 0.9984 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N14 mock treatment 149160.0 10800.0 0.42 123680.0 -6300.0 -0.24 0.1302 0.2697 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N15 mock treatment 147960.0 9640.0 0.37 110640.0 -19300.0 -0.73 -0.2488 -0.3047 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N16 mock treatment 144440.0 6120.0 0.24 108080.0 -21900.0 -0.82 -0.4133 -0.483 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N17 mock treatment 146520.0 8200.0 0.32 103040.0 -26900.0 -1.01 -0.49 -0.4622 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N18 mock treatment 136080.0 -2240.0 -0.09 96160.0 -33800.0 -1.27 -0.959 -0.7537 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N19 mock treatment 135920.0 -2400.0 -0.09 103160.0 -26800.0 -1.01 -0.7777 -0.7692 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N20 mock treatment 137600.0 -718.0 -0.03 104240.0 -25700.0 -0.97 -0.7029 -0.7272 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N21 mock treatment 137400.0 -918.0 -0.04 109320.0 -20700.0 -0.78 -0.5736 -0.7388 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N22 mock treatment 132480.0 -5840.0 -0.23 102200.0 -27800.0 -1.04 -0.8975 -0.8411 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N23 mock treatment 122440.0 -15900.0 -0.62 104880.0 -25100.0 -0.94 -1.1018 -0.9788 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 N24 mock treatment 112840.0 -25500.0 -0.99 117120.0 -12900.0 -0.48 -1.0404 -0.9457 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O01 compound treatment 108320.0 -30000.0 -1.16 106120.0 -23900.0 -0.9 -1.4563 -0.9916 3065902 Maybridge4_004724 Cc1nn(c(N)c1C(=S)N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O02 compound treatment 119080.0 -19200.0 -0.75 104640.0 -25300.0 -0.95 -1.2004 -0.9928 1470895 Maybridge4_004725 CCOC(=O)c1cc(Sc2ccccc2NC(=O)c3ccccc3)cc(n1)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O03 compound treatment 89920.0 -48400.0 -1.88 24680.0 -105000.0 -3.95 -4.1225 -0.9421 3065903 Maybridge4_004726 Cc1cc(no1)c2nnc(SCC(=O)c3ccccc3Cl)n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O04 compound treatment 106440.0 -31900.0 -1.24 67680.0 -62300.0 -2.34 -2.5281 -0.9557 1417512 Maybridge4_004727 Cc1c(C#N)c(Sc2ccccc2NC(=O)c3ccccc3)nc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O05 compound treatment 9920.0 -128000.0 -4.98 6080.0 -124000.0 -4.65 -6.811 -0.9994 3065905 Maybridge4_004728 CC(C)(C)c1ccc(OCC(=N)NC(=O)c2ccc(OC(F)(F)F)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O06 compound treatment 59760.0 -78600.0 -3.05 33920.0 -96100.0 -3.61 -4.7047 -0.9965 1176898 Maybridge4_004729 OC(C(O)c1nc2cc(Cl)ccc2[nH]1)c3nc4cc(Cl)ccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O07 compound treatment 91760.0 -46600.0 -1.81 48000.0 -82000.0 -3.08 -3.4531 -0.9678 3065906 Maybridge4_004730 Cc1nc(nc(Sc2nnc([nH]2)c3cccs3)c1C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O08 compound treatment 129640.0 -8680.0 -0.34 60040.0 -69900.0 -2.63 -2.0943 -0.7913 3179103 Maybridge4_004731 CC(=O)N/C(=C\c1ccc2ccccc2c1)/C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O09 compound treatment 128800.0 -9520.0 -0.37 91200.0 -38800.0 -1.46 -1.2904 -0.8593 3179104 Maybridge4_004732 NC(=O)C1=CN(Cc2ccccc2)CCC1C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O10 compound treatment 32960.0 -105000.0 -4.09 14200.0 -116000.0 -4.35 -5.9634 -0.9995 3065908 Maybridge4_004733 CC(C)(C)c1cc(c2nnc(o2)c3cccs3)n(Cc4ccc(F)cc4)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O11 compound treatment 11320.0 -127000.0 -4.93 7120.0 -123000.0 -4.61 -6.745 -0.9995 3179105 Maybridge4_004734 FC(F)(F)COc1cc(cc(OCC(F)(F)F)n1)c2nnc(S)n2Cc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O12 compound treatment 10160.0 -128000.0 -4.97 8600.0 -121000.0 -4.56 -6.7375 -0.999 3065960 Maybridge4_004735 Clc1ccc(Sc2c[nH]nc2c3ccc4OCCOc4c3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O13 compound treatment 141480.0 3160.0 0.12 121280.0 -8700.0 -0.33 -0.1442 -0.4134 1741446 Maybridge4_004736 CC(C)(C)NC(=O)N1CCN(CC1)c2ccc(C#N)cn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O14 compound treatment 111160.0 -27200.0 -1.05 89400.0 -40600.0 -1.52 -1.8221 -0.9838 1571449 Maybridge4_004737 CCOc1cc(N2CCOCC2)c(OCC)cc1NC(=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O15 compound treatment 121080.0 -17200.0 -0.67 102880.0 -27100.0 -1.02 -1.1922 -0.9793 3065932 Maybridge4_004738 N/C(=N\O)/c1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O16 compound treatment 44000.0 -94300.0 -3.66 23480.0 -107000.0 -4.0 -5.4142 -0.999 1468379 Maybridge4_004739 CC(C)c1ccc(NC(=O)N2CCCN(CCOc3ccccc3)CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O17 compound treatment 11160.0 -127000.0 -4.93 7400.0 -123000.0 -4.6 -6.7419 -0.9994 3065933 Maybridge4_004740 COc1ccc(OCC(=N)NC(=S)Nc2cccc(c2)C(F)(F)F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O18 compound treatment 129920.0 -8400.0 -0.33 85400.0 -44600.0 -1.67 -1.4136 -0.8292 3065934 Maybridge4_004741 NC(=C(C#N)C#N)Nc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O19 compound treatment 133200.0 -5120.0 -0.2 99520.0 -30500.0 -1.14 -0.9489 -0.8177 3065935 Maybridge4_004742 Oc1nnc(SCC(=O)N2CCC(CC2)C(F)(F)F)n1c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O20 compound treatment 116800.0 -21500.0 -0.83 72920.0 -57100.0 -2.14 -2.1048 -0.9156 3065936 Maybridge4_004743 Cc1cc(Br)cnc1N/C=N/O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O21 compound treatment 51400.0 -86900.0 -3.37 13760.0 -116000.0 -4.36 -5.4691 -0.9919 3179106 Maybridge4_004744 Cc1nc(c(s1)C(=O)Sc2cccc(c2)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O22 mock treatment 136680.0 -1640.0 -0.06 99760.0 -30200.0 -1.13 -0.847 -0.7456 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O23 mock treatment 127000.0 -11300.0 -0.44 109480.0 -20500.0 -0.77 -0.8547 -0.9646 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 O24 mock treatment 123640.0 -14700.0 -0.57 122600.0 -7380.0 -0.28 -0.5986 -0.9452 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P01 mock treatment 102240.0 -36100.0 -1.4 118200.0 -11800.0 -0.44 -1.3025 -0.8873 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P02 mock treatment 112760.0 -25600.0 -0.99 105120.0 -24900.0 -0.93 -1.3611 -0.9995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P03 mock treatment 115160.0 -23200.0 -0.9 100240.0 -29700.0 -1.12 -1.4247 -0.9942 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P04 mock treatment 122960.0 -15400.0 -0.6 99200.0 -30800.0 -1.16 -1.2383 -0.9526 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P05 mock treatment 138200.0 -118.0 0.0 97200.0 -32800.0 -1.23 -0.8733 -0.7097 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P06 mock treatment 139920.0 1600.0 0.06 102280.0 -27700.0 -1.04 -0.6913 -0.6637 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P07 mock treatment 145520.0 7200.0 0.28 100240.0 -29700.0 -1.12 -0.5918 -0.5142 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P08 mock treatment 137360.0 -958.0 -0.04 100960.0 -29000.0 -1.09 -0.7965 -0.7308 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P09 mock treatment 130240.0 -8080.0 -0.31 92600.0 -37400.0 -1.4 -1.2137 -0.8443 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P10 mock treatment 143240.0 4920.0 0.19 103280.0 -26700.0 -1.0 -0.5736 -0.5623 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P11 mock treatment 142040.0 3720.0 0.14 111840.0 -18100.0 -0.68 -0.3794 -0.545 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P12 mock treatment 142000.0 3680.0 0.14 112960.0 -17000.0 -0.64 -0.3508 -0.5358 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P13 mock treatment 141160.0 2840.0 0.11 106320.0 -23700.0 -0.89 -0.55 -0.6146 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P14 mock treatment 145480.0 7160.0 0.28 102400.0 -27600.0 -1.04 -0.5355 -0.4996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P15 mock treatment 138880.0 562.0 0.02 98200.0 -31800.0 -1.19 -0.8281 -0.6941 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P16 mock treatment 131920.0 -6400.0 -0.25 105320.0 -24700.0 -0.93 -0.8301 -0.8661 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P17 mock treatment 143280.0 4960.0 0.19 93080.0 -36900.0 -1.39 -0.8432 -0.603 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P18 mock treatment 128920.0 -9400.0 -0.36 91560.0 -38400.0 -1.44 -1.2776 -0.8589 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P19 mock treatment 131400.0 -6920.0 -0.27 98920.0 -31100.0 -1.17 -1.0142 -0.8477 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P20 mock treatment 119360.0 -19000.0 -0.74 93560.0 -36400.0 -1.37 -1.4868 -0.9577 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P21 mock treatment 108720.0 -29600.0 -1.15 95400.0 -34600.0 -1.3 -1.7299 -0.9981 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P22 mock treatment 116880.0 -21400.0 -0.83 105840.0 -24100.0 -0.91 -1.2289 -0.9991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P23 mock treatment 104000.0 -34300.0 -1.33 108280.0 -21700.0 -0.81 -1.5175 -0.9722 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2062 P24 mock treatment 100960.0 -37400.0 -1.45 103520.0 -26500.0 -0.99 -1.7273 -0.983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A01 compound treatment 36080.0 -76500.0 -2.97 70800.0 -64800.0 -2.43 -3.8178 -0.9952 1360118 TimTec1_000001 CC1=C(C(C2=C(CC(CC2=O)c3ccccc3)N1)c4ccncc4)C(=O)OC5CCCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A02 compound treatment 73440.0 -39100.0 -1.52 143520.0 7900.0 0.3 -0.8629 -0.5583 1352805 TimTec1_000002 CCOC(=O)c1cc2ccccc2oc1=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A03 compound treatment 99600.0 -12900.0 -0.5 178600.0 43000.0 1.61 0.7858 0.4651 1269647 TimTec1_000003 CN1C2CCC1CC(C2)NC3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A04 compound treatment 5800.0 -107000.0 -4.14 11240.0 -124000.0 -4.67 -6.2292 -0.9982 1717432 TimTec1_000004 NC1=C(C#N)C2=C(CCCC2)C(c3ccccc3)C1(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A05 compound treatment 126400.0 13900.0 0.54 204160.0 68500.0 2.57 2.1995 0.8369 1640292 TimTec1_000005 CC1C2CC(C(C2=O)S(=O)(=O)N3CCOCC3)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A06 compound treatment 92280.0 -20300.0 -0.79 197200.0 61600.0 2.31 1.0786 0.4418 1432692 TimTec1_000006 CC(=C)C[N+](C)(C)Cc1c(C)ccc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A07 compound treatment 84640.0 -27900.0 -1.08 173240.0 37600.0 1.41 0.2331 0.131 3209477 TimTec1_000007 O=C1N(CSc2nc3ccccc3s2)C(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A08 compound treatment 107160.0 -5370.0 -0.21 165920.0 30300.0 1.14 0.6567 0.568 1665724 TimTec1_000008 CC1(C)CC(=C(C(C2C(=O)CC(C)(C)CC2=O)c3ccccc3)C(=O)C1)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A09 compound treatment 123240.0 10700.0 0.42 205600.0 70000.0 2.63 2.151 0.8089 1568897 TimTec1_000009 CCOC(=O)c1ccc(NC(=O)NC2OC(CO)C(O)C(O)C2O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A10 compound treatment 131920.0 19400.0 0.75 219480.0 83900.0 3.15 2.7575 0.8521 3082080 TimTec1_000010 Cc1cc[n+](Cc2ccccn2)c(N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A11 compound treatment 106320.0 -6210.0 -0.24 190560.0 54900.0 2.06 1.2876 0.6202 1782663 TimTec1_000011 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3NC2/C=C/c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A12 compound treatment 146160.0 33600.0 1.3 192640.0 57000.0 2.14 2.4359 0.9718 3082082 TimTec1_000012 CCCC1CCCCCC1NC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A13 compound treatment 132880.0 20300.0 0.79 185160.0 49500.0 1.86 1.873 0.9272 3508726 TimTec1_000013 CCC(=O)NC1CC(CC=C1C)C(C)(C)NC(=O)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A14 compound treatment 89240.0 -23300.0 -0.9 183360.0 47700.0 1.79 0.6279 0.3129 3209587 TimTec1_000014 OC(=O)CCC(=O)N=S(c1ccccc1)c2ccccc2.Oc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A15 compound treatment 122960.0 10400.0 0.4 171840.0 36200.0 1.36 1.2473 0.8794 1459520 TimTec1_000015 COc1ccccc1c2nnc(N)[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A16 compound treatment 5800.0 -107000.0 -4.14 12240.0 -123000.0 -4.63 -6.2027 -0.9984 3082084 TimTec1_000016 Cc1[nH]c2ccccc2c1Sc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A17 compound treatment 111880.0 -654.0 -0.03 214160.0 78500.0 2.95 2.0665 0.701 1172294 TimTec1_000017 Cc1cc(C)c(NC(=O)CCNC2CCCCC2)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A18 compound treatment 57840.0 -54700.0 -2.12 162440.0 26800.0 1.01 -0.7888 -0.3358 1183562 TimTec1_000018 CCOC(=O)c1c(CN2CCOCC2)n(c3ccccc3)c4ccc(O)cc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A19 compound treatment 112600.0 66.3 0.0 208800.0 73200.0 2.75 1.944 0.7078 1230606 TimTec1_000019 CCN1CCN(CC1)c2ccc(NC(=O)c3cccc(Br)c3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A20 compound treatment 93560.0 -19000.0 -0.74 181760.0 46100.0 1.73 0.704 0.3741 1045901 TimTec1_000020 COC(=O)c1cc2ccccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A21 compound treatment 5320.0 -107000.0 -4.16 18600.0 -117000.0 -4.39 -6.0471 -0.9996 3209588 TimTec1_000021 CSc1ccc(/C=N/n2nnnc2Nc3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A22 compound treatment 31680.0 -80900.0 -3.14 66840.0 -68800.0 -2.58 -4.0436 -0.9953 3082088 TimTec1_000022 OC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A23 mock treatment 128080.0 15500.0 0.6 203280.0 67700.0 2.54 2.2222 0.8514 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 A24 mock treatment 128600.0 16100.0 0.62 164120.0 28500.0 1.07 1.1972 0.967 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B01 compound treatment 36200.0 -76300.0 -2.96 81480.0 -54100.0 -2.03 -3.5311 -0.9831 1462495 TimTec1_000023 CSc1c(CC(=O)Nc2ccccc2)n(C)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B02 compound treatment 5160.0 -107000.0 -4.17 40400.0 -95200.0 -3.57 -5.4729 -0.9971 3209589 TimTec1_000024 Nc1c(sc2nc(N)c(C#N)cc12)C(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B03 compound treatment 124680.0 12100.0 0.47 189040.0 53400.0 2.01 1.751 0.8501 1291339 TimTec1_000025 CCOC(=O)c1c(CN2CCOCC2)n(C)c3ccc(O)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B04 compound treatment 67440.0 -45100.0 -1.75 146440.0 10800.0 0.41 -0.95 -0.5289 1292419 TimTec1_000026 O=C(Oc1ccc(OC(=O)c2ccco2)cc1)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B05 compound treatment 147680.0 35100.0 1.36 204120.0 68500.0 2.57 2.7822 0.956 1346277 TimTec1_000027 O=C(N1CCCCC1)c2ccc(cc2)C(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B06 compound treatment 140200.0 27700.0 1.07 185000.0 49400.0 1.85 2.0696 0.9663 1037513 TimTec1_000028 O=C1N(C(=O)c2ccccc12)c3nccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B07 compound treatment 100400.0 -12100.0 -0.47 174200.0 38600.0 1.45 0.691 0.4538 3209590 TimTec1_000029 Cc1ccc(s1)C(=O)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B08 compound treatment 69800.0 -42700.0 -1.66 147280.0 11700.0 0.44 -0.863 -0.5032 1598558 TimTec1_000030 O=C(Nc1ccccc1)C(=S)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B09 compound treatment 9600.0 -103000.0 -3.99 36560.0 -99100.0 -3.72 -5.453 -0.9994 1166367 TimTec1_000031 CCOC(=O)c1c(CN2CCCCC2)n(c3ccccc3)c4cc(Br)c(OC)cc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B10 compound treatment 77920.0 -34600.0 -1.34 95320.0 -40300.0 -1.51 -2.0191 -0.9982 3081103 TimTec1_000032 C/C(=N\C1CC1)/c2c(C)[nH]n(c3nc4ccccc4s3)c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B11 compound treatment 127360.0 14800.0 0.58 190400.0 54800.0 2.06 1.8606 0.8715 1692568 TimTec1_000033 Fc1ccc(cc1)C(=O)CCCN2CCNCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B12 compound treatment 92760.0 -19800.0 -0.77 116680.0 -18900.0 -0.71 -1.0451 -0.9993 3209591 TimTec1_000034 CCN1C(=O)/C(=C\2/C=Cc3ccccc3N2CC)/N(C)C1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B13 compound treatment 61400.0 -51100.0 -1.98 76520.0 -59100.0 -2.22 -2.9713 -0.9985 1611433 TimTec1_000035 CC(=O)Oc1ccc2occ(C(=O)c3ccc(Br)s3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B14 compound treatment 67400.0 -45100.0 -1.75 77920.0 -57700.0 -2.17 -2.7695 -0.9945 1351179 TimTec1_000036 O=C(c1nnn(c1Nc2ccccc2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B15 compound treatment 135600.0 23100.0 0.89 200480.0 64900.0 2.43 2.3542 0.9077 1357665 TimTec1_000037 OC(=O)c1cccc(CN2CCN(CC2)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B16 compound treatment 119040.0 6510.0 0.25 188120.0 52500.0 1.97 1.5718 0.7912 1209399 TimTec1_000038 O=C(NCCc1ccccc1)c2ccc(cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B17 compound treatment 121360.0 8830.0 0.34 198040.0 62400.0 2.34 1.8988 0.8019 3209592 TimTec1_000039 CNC(=O)CSCc1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B18 compound treatment 6640.0 -106000.0 -4.11 17840.0 -118000.0 -4.42 -6.031 -0.9993 3209593 TimTec1_000040 O=C(Oc1nc2ccccc2s1)/C=C/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B19 compound treatment 56720.0 -55800.0 -2.17 130080.0 -5540.0 -0.21 -1.6783 -0.7714 1421610 TimTec1_000041 CN(C(=O)Oc1cccc(c1)C(=O)Nc2ccc(C)c(C)c2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B20 compound treatment 54960.0 -57600.0 -2.23 118640.0 -17000.0 -0.64 -2.0302 -0.874 3209594 TimTec1_000042 COC(=O)NC(Nc1cccc(c1)C(F)(F)F)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B21 compound treatment 72120.0 -40400.0 -1.57 151840.0 16200.0 0.61 -0.6783 -0.4032 1920491 TimTec1_000043 COc1ccc2nc(NC(=N)N)nc(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B22 compound treatment 30320.0 -82200.0 -3.19 103680.0 -31900.0 -1.2 -3.1032 -0.9106 1644751 TimTec1_000044 COc1ccc(cc1)C(=O)Oc2csc(=S)n2C(=O)c3ccc(OC)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B23 mock treatment 133640.0 21100.0 0.82 200720.0 65100.0 2.44 2.3068 0.8952 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 B24 mock treatment 133360.0 20800.0 0.81 190320.0 54700.0 2.05 2.0231 0.917 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C01 compound treatment 82960.0 -29600.0 -1.15 193440.0 57800.0 2.17 0.7231 0.2946 1157703 TimTec1_000045 COc1ccc2C3CC(=Nc4ccccc4N3C(=O)c2c1OC)c5ccc(Br)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C02 compound treatment 108480.0 -4050.0 -0.16 171000.0 35400.0 1.33 0.8278 0.619 3209595 TimTec1_000046 COC(=O)CC1=CC(C)(CC(=O)OC)C(C#N)(C#N)C(=C1C#N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C03 compound treatment 100440.0 -12100.0 -0.47 167760.0 32100.0 1.21 0.5212 0.4027 1704164 TimTec1_000047 CCCCN(C1CC2CCC(C1)N2C)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C04 compound treatment 14000.0 -98500.0 -3.82 35840.0 -99800.0 -3.74 -5.3514 -0.9999 1258841 TimTec1_000048 O=C1C(=C2CCCCC2C(c3ccco3)C1(C#N)C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C05 compound treatment 121640.0 9110.0 0.35 171760.0 36100.0 1.36 1.209 0.8625 1916777 TimTec1_000049 CC1C/2CC(C(\C2=N\O)S(=O)(=O)N3CCOCC3)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C06 compound treatment 34640.0 -77900.0 -3.02 75200.0 -60400.0 -2.27 -3.7405 -0.99 3209596 TimTec1_000050 COC1OC(COC(=O)C)C(OC(=O)C)C(C#N)(C#N)C1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C07 compound treatment 7560.0 -105000.0 -4.07 33520.0 -102000.0 -3.83 -5.5896 -0.9995 1250478 TimTec1_000051 OC(COc1ccc(Nc2ccccc2)cc1)COc3ccc(Nc4ccccc4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C08 compound treatment 93120.0 -19400.0 -0.75 143960.0 8340.0 0.31 -0.3113 -0.3816 1606069 TimTec1_000052 CC(C)C(C1C(=O)CC(C)(C)CC1=O)C2=C(O)CC(C)(C)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C09 compound treatment 103640.0 -8890.0 -0.35 156040.0 20400.0 0.77 0.298 0.3545 3081440 TimTec1_000053 CCNC(=O)c1ccc(Cl)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C10 compound treatment 110280.0 -2250.0 -0.09 143640.0 8020.0 0.3 0.151 0.4818 3209597 TimTec1_000054 Cc1cc[n+](CCOc2ccc(N)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C11 compound treatment 86360.0 -26200.0 -1.02 155840.0 20200.0 0.76 -0.1814 -0.1431 1677737 TimTec1_000055 CCCCC(=O)N1C(C)CC(Nc2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C12 compound treatment 139200.0 26700.0 1.03 136040.0 421.0 0.02 0.7428 0.7178 3081441 TimTec1_000056 CCOC(=O)CCCc1ccc(/C=C/C(=O)O)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C13 compound treatment 137800.0 25300.0 0.98 157680.0 22100.0 0.83 1.2787 0.9965 3081442 TimTec1_000057 COC(=O)c1nsc(Cl)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C14 compound treatment 88240.0 -24300.0 -0.94 140160.0 4540.0 0.17 -0.546 -0.57 1003566 TimTec1_000058 S=C(Nc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C15 compound treatment 92400.0 -20100.0 -0.78 135920.0 301.0 0.01 -0.5444 -0.6968 1060631 TimTec1_000059 COC(=O)C1=NNC(C1)(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C16 compound treatment 108520.0 -4010.0 -0.16 166320.0 30700.0 1.15 0.7047 0.606 3081443 TimTec1_000060 CN(C)/C=C(\C=[N+](C)C)/c1n[nH]cc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C17 compound treatment 107600.0 -4930.0 -0.19 145880.0 10300.0 0.39 0.137 0.3185 1149044 TimTec1_000061 Cc1cc(Cl)c(C(=O)N)c(C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C18 compound treatment 95920.0 -16600.0 -0.64 145520.0 9900.0 0.37 -0.193 -0.2594 1602135 TimTec1_000062 CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccncc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C19 compound treatment 89640.0 -22900.0 -0.89 165840.0 30200.0 1.13 0.1739 0.1207 3081444 TimTec1_000063 CCN1CCN(CC1)c2ccc(NC(=O)/C=C/c3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C20 compound treatment 101240.0 -11300.0 -0.44 151880.0 16300.0 0.61 0.1217 0.162 1241763 TimTec1_000064 Oc1ccc2occ(C(=O)c3cccs3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C21 compound treatment 17600.0 -94900.0 -3.68 126680.0 -8940.0 -0.34 -2.8418 -0.7683 3081445 TimTec1_000065 Nc1nnnn1/N=C\2/C(=O)Nc3ccc(Br)cc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C22 compound treatment 5200.0 -107000.0 -4.16 9160.0 -126000.0 -4.75 -6.3009 -0.9979 1336111 TimTec1_000066 COC(=O)CCc1[nH]c2ccccc2c1Sc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C23 mock treatment 113280.0 746.0 0.03 177280.0 41700.0 1.56 1.1261 0.7201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 C24 mock treatment 129360.0 16800.0 0.65 183960.0 48300.0 1.81 1.7446 0.9048 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D01 compound treatment 4040.0 -108000.0 -4.21 7760.0 -128000.0 -4.8 -6.3699 -0.9979 1420975 TimTec1_000067 CSc1c(CC(=O)Nc2ccc(C)cc2)[nH]c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D02 compound treatment 70360.0 -42200.0 -1.64 147480.0 11900.0 0.45 -0.8423 -0.4967 3209598 TimTec1_000068 OC(=O)CCCC=C(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D03 compound treatment 75360.0 -37200.0 -1.44 143360.0 7740.0 0.29 -0.8144 -0.5535 3209599 TimTec1_000069 Cc1[nH]c2ccccc2c1/C=N/CCc3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D04 compound treatment 118040.0 5510.0 0.21 148840.0 13200.0 0.5 0.502 0.9291 3081446 TimTec1_000070 Brc1ccc(OC(=O)c2ccco2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D05 compound treatment 122000.0 9470.0 0.37 173240.0 37600.0 1.41 1.2581 0.8623 3081447 TimTec1_000071 CCC(=O)n1c(SC)nc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D06 compound treatment 129400.0 16900.0 0.65 158200.0 22600.0 0.85 1.062 0.9918 3209600 TimTec1_000072 Nc1nc(SCC(=O)NC2CCCCC2)c(C#N)cc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D07 compound treatment 110960.0 -1570.0 -0.06 143800.0 8180.0 0.31 0.1739 0.5556 3081448 TimTec1_000073 CCCc1ccc(s1)/C(=N/O)/C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D08 compound treatment 8240.0 -104000.0 -4.05 12840.0 -123000.0 -4.61 -6.1198 -0.9979 3209601 TimTec1_000074 CCOC(=O)CCSc1ccccn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D09 compound treatment 48920.0 -63600.0 -2.47 93640.0 -42000.0 -1.58 -2.8594 -0.9765 1380002 TimTec1_000075 CCOC(=O)c1c(CN(C)C)n(c2ccccc2)c3cc(Br)c(OC)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D10 compound treatment 47240.0 -65300.0 -2.53 83000.0 -52600.0 -1.97 -3.1878 -0.9924 3081452 TimTec1_000076 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccc(Cl)cc4Cl)C(=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D11 compound treatment 117640.0 5110.0 0.2 141040.0 5420.0 0.2 0.284 0.9999 1674072 TimTec1_000077 Cn1c(CC(=O)O)c(c2ccccc12)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D12 compound treatment 82480.0 -30100.0 -1.17 117680.0 -17900.0 -0.67 -1.3006 -0.9659 1452087 TimTec1_000078 CCSc1nnc-2c(OC(Nc3ccccc32)C(=O)c4ccccc4)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D13 compound treatment 61960.0 -50600.0 -1.96 100000.0 -35600.0 -1.34 -2.3328 -0.9825 1648799 TimTec1_000079 C(CN1CCN(CCSc2ccccc2)CC1)Sc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D14 compound treatment 14160.0 -98400.0 -3.82 54600.0 -81000.0 -3.04 -4.8491 -0.9937 1276972 TimTec1_000080 Clc1ccccc1CN(Cc2cccnc2)C(=S)NC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D15 compound treatment 85800.0 -26700.0 -1.04 129520.0 -6100.0 -0.23 -0.8953 -0.8429 1186617 TimTec1_000081 Cc1c([nH]c2ccc(OCc3ccccc3)cc12)C(=O)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D16 compound treatment 7120.0 -105000.0 -4.09 12760.0 -123000.0 -4.61 -6.1527 -0.9982 1357113 TimTec1_000082 CC1Oc2ccccc2OC1(O)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D17 compound treatment 109680.0 -2850.0 -0.11 144720.0 9100.0 0.34 0.1632 0.4546 3081458 TimTec1_000083 Brc1ccccc1NCn2nc(oc2=S)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D18 compound treatment 55880.0 -56700.0 -2.2 99520.0 -36100.0 -1.35 -2.5124 -0.973 3209728 TimTec1_000084 Fc1ccccc1OC(=O)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D19 compound treatment 68640.0 -43900.0 -1.7 88760.0 -46900.0 -1.76 -2.4478 -0.9999 1270584 TimTec1_000085 Cc1ccc(cc1)S(=O)(=O)N2c3ccccc3C(C)(CC2(C)C)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D20 compound treatment 94960.0 -17600.0 -0.68 138520.0 2900.0 0.11 -0.4052 -0.5867 3081461 TimTec1_000086 FC(F)(F)c1cccc(c1)c2ccc(/C=N\C3CCS(=O)(=O)C3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D21 compound treatment 6160.0 -106000.0 -4.13 9760.0 -126000.0 -4.72 -6.2586 -0.9977 1450123 TimTec1_000087 CCOC(=O)c1c(C)n(c2cccc(C)c2)c3ccc(O)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D22 compound treatment 26360.0 -86200.0 -3.34 50480.0 -85100.0 -3.2 -4.6237 -0.9997 3209729 TimTec1_000088 Cc1cccc(c1)C2Sc3ccccc3N=C4C2C(=O)c5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D23 mock treatment 109800.0 -2730.0 -0.11 161320.0 25700.0 0.96 0.6071 0.6256 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 D24 mock treatment 114520.0 1990.0 0.08 148000.0 12400.0 0.46 0.3831 0.8133 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E01 compound treatment 40160.0 -72400.0 -2.81 111800.0 -23800.0 -0.89 -2.6178 -0.8883 3209730 TimTec1_000089 CSc1ccccc1NC(=O)c2cc3NC4C(CCc5ccccc45)C(n3n2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E02 compound treatment 5960.0 -107000.0 -4.14 9480.0 -126000.0 -4.73 -6.2715 -0.9977 3081503 TimTec1_000090 Nc1c(C#N)c(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E03 compound treatment 104120.0 -8410.0 -0.33 144680.0 9060.0 0.34 0.0096 0.0205 3081507 TimTec1_000091 Cc1c(Br)c(nn1CC(=O)N2CCOCC2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E04 compound treatment 9840.0 -103000.0 -3.98 13360.0 -122000.0 -4.59 -6.0621 -0.9975 1912602 TimTec1_000092 Brc1cccc(c1)C2C3CCCCC3=C(C#N)C(=O)C2(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E05 compound treatment 120920.0 8390.0 0.33 142960.0 7340.0 0.28 0.4249 0.9966 3209731 TimTec1_000093 C[N+](C)(C)CC1CCCC1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E06 compound treatment 93360.0 -19200.0 -0.74 118760.0 -16900.0 -0.63 -0.9735 -0.9968 3081510 TimTec1_000094 [N-]=[N+]=NCc1noc(n1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E07 compound treatment 72040.0 -40500.0 -1.57 106080.0 -29500.0 -1.11 -1.8949 -0.9854 1182023 TimTec1_000095 CCCN(C#N)c1nc(NC(C)C)nc(NC(C)C)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E08 compound treatment 118920.0 6390.0 0.25 145560.0 9940.0 0.37 0.439 0.9802 3081512 TimTec1_000096 O=C(NCC[n+]1ccc2ccccc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E09 compound treatment 111400.0 -1130.0 -0.04 145240.0 9620.0 0.36 0.2242 0.6164 1029436 TimTec1_000097 OC(=O)CCC(=O)Oc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E10 compound treatment 113600.0 1070.0 0.04 152080.0 16500.0 0.62 0.4661 0.7528 3209732 TimTec1_000098 Nc1ccc(OCC(O)C[n+]2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E11 compound treatment 105400.0 -7130.0 -0.28 140200.0 4580.0 0.17 -0.0741 -0.2275 3081515 TimTec1_000099 O=C(Nc1cccc(NC(=O)/C=C/c2ccco2)n1)/C=C/c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E12 compound treatment 121800.0 9270.0 0.36 153040.0 17400.0 0.65 0.7166 0.9603 1009007 TimTec1_000100 CCCC(=O)NCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E13 compound treatment 116400.0 3870.0 0.15 145720.0 10100.0 0.38 0.3742 0.9177 1705451 TimTec1_000101 CC1C2COCC2CC(C1O)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E14 compound treatment 111520.0 -1010.0 -0.04 135400.0 -219.0 -0.01 -0.0336 -0.8366 1074947 TimTec1_000102 Cc1ccc[n+](Cc2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E15 compound treatment 103520.0 -9010.0 -0.35 144960.0 9340.0 0.35 6.0E-4 0.0012 1394494 TimTec1_000103 Nc1ccc(c2nc3cc(Cl)ccc3o2)c(O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E16 compound treatment 107760.0 -4770.0 -0.19 141320.0 5700.0 0.21 0.0203 0.0719 3209733 TimTec1_000104 CN(C)/C=C(\C=[N+](C)C)/c1cc([nH]n1)\C(=C/N(C)C)\C=[N+](C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E17 compound treatment 22000.0 -90500.0 -3.51 65520.0 -70100.0 -2.63 -4.3442 -0.9899 3081522 TimTec1_000105 Oc1ccc(Cl)cc1/N=C/c2ccc(o2)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E18 compound treatment 6920.0 -106000.0 -4.1 14360.0 -121000.0 -4.55 -6.1157 -0.9986 1633318 TimTec1_000106 Oc1ccc2occ(C(=O)c3ccc(Oc4ccccc4)cc3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E19 compound treatment 110920.0 -1610.0 -0.06 155600.0 20000.0 0.75 0.486 0.6458 1221609 TimTec1_000107 CCOC(=O)C1(COC(=O)C1)c2csc(N)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E20 compound treatment 83520.0 -29000.0 -1.13 122960.0 -12700.0 -0.48 -1.132 -0.9264 1365512 TimTec1_000108 CSc1c(CC(=O)NCCc2ccccc2)n(C)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E21 compound treatment 106520.0 -6010.0 -0.23 137240.0 1620.0 0.06 -0.122 -0.5058 3081562 TimTec1_000109 Cc1c(/C=N/c2cccc3nsnc23)c(O)n4c5ccccc5nc4c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E22 compound treatment 6960.0 -106000.0 -4.1 9800.0 -126000.0 -4.72 -6.2356 -0.9975 1408177 TimTec1_000110 O=C(CCN1CCCCC1)c2cc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E23 mock treatment 113800.0 1270.0 0.05 142240.0 6620.0 0.25 0.2105 0.8308 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 E24 mock treatment 101840.0 -10700.0 -0.41 160120.0 24500.0 0.92 0.3568 0.3537 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F01 compound treatment 82520.0 -30000.0 -1.16 161960.0 26300.0 0.99 -0.1244 -0.0814 1212077 TimTec1_000111 CCOC(=O)c1cc2ccccc2nc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F02 compound treatment 104520.0 -8010.0 -0.31 174320.0 38700.0 1.45 0.8072 0.5434 3209734 TimTec1_000112 C=CCNC(=O)CC1CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F03 compound treatment 77480.0 -35100.0 -1.36 145240.0 9620.0 0.36 -0.7064 -0.502 3209735 TimTec1_000113 COc1ccc(O)c(c1)c2c[nH]c(=S)nc2c3cc(OC)ccc3OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F04 compound treatment 105520.0 -7010.0 -0.27 144080.0 8460.0 0.32 0.0321 0.0768 1743325 TimTec1_000114 COc1ccc2nc3-c4cccc5cccc(-c3nc2c1)c45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F05 compound treatment 107480.0 -5050.0 -0.2 137760.0 2140.0 0.08 -0.0818 -0.3861 2104259 TimTec1_000115 Brc1cccc(c1)c2n[nH]c(=O)[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F06 compound treatment 124640.0 12100.0 0.47 151760.0 16100.0 0.61 0.7605 0.9921 1644388 TimTec1_000116 O=S(=O)(CCc1ccncc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F07 compound treatment 80200.0 -32300.0 -1.25 90160.0 -45500.0 -1.71 -2.0935 -0.9886 1066566 TimTec1_000117 Cc1ccc(cc1)S(=O)(=O)N2CCC(=O)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F08 compound treatment 117560.0 5030.0 0.2 155640.0 20000.0 0.75 0.6692 0.8621 1595822 TimTec1_000118 Nc1ccc(cc1)C(=O)NCC2CCCN3CCCCC23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F09 compound treatment 116680.0 4150.0 0.16 152360.0 16700.0 0.63 0.5581 0.8604 3209736 TimTec1_000119 CN(C)Cc1c(C#N)c2ccccc2n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F10 compound treatment 115520.0 2990.0 0.12 134280.0 -1340.0 -0.05 0.0464 0.3675 3081571 TimTec1_000120 Cc1c(O)n(nc1/C=N/n2cnnc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F11 compound treatment 85400.0 -27100.0 -1.05 115760.0 -19900.0 -0.75 -1.2715 -0.9857 3209737 TimTec1_000121 Oc1ccc(cc1)n2cccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F12 compound treatment 46880.0 -65700.0 -2.55 50560.0 -85100.0 -3.19 -4.0586 -0.9937 1378112 TimTec1_000122 CC(C)(C)C(=O)c1sc2nc3CCCc3c(c4cccs4)c2c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F13 compound treatment 124520.0 12000.0 0.47 142880.0 7260.0 0.27 0.5216 0.9676 1389415 TimTec1_000123 Clc1cccc(OCCN2CCOCC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F14 compound treatment 43440.0 -69100.0 -2.68 48560.0 -87100.0 -3.27 -4.2061 -0.9952 3209738 TimTec1_000124 COc1ccc(C/N=C/C2C(=O)N(N=C2C(F)(F)F)c3nc4ccccc4s3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F15 compound treatment 126440.0 13900.0 0.54 140840.0 5220.0 0.2 0.5201 0.906 1562364 TimTec1_000125 CN1CCN(CCOc2ccccc2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F16 compound treatment 84520.0 -28000.0 -1.09 103880.0 -31700.0 -1.19 -1.6109 -0.999 1380422 TimTec1_000126 Brc1ccccc1OCc2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F17 compound treatment 75520.0 -37000.0 -1.44 105200.0 -30400.0 -1.14 -1.8228 -0.9935 1337811 TimTec1_000127 COc1ccc(NC(=O)c2ccc3nc(C)c(C)nc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F18 compound treatment 60480.0 -52100.0 -2.02 103880.0 -31700.0 -1.19 -2.2705 -0.9683 3209739 TimTec1_000128 O=C(/C=C/C(=O)c1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F19 compound treatment 7840.0 -105000.0 -4.06 11200.0 -124000.0 -4.67 -6.1743 -0.9976 1683844 TimTec1_000129 CC1(C)CC(C)(c2ccccc2)c3cc(SC#N)ccc3N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F20 compound treatment 112880.0 346.0 0.01 150040.0 14400.0 0.54 0.3922 0.7244 1442200 TimTec1_000130 CC1CCN(CC(O)COc2c(F)cc(Br)cc2F)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F21 compound treatment 108720.0 -3810.0 -0.15 136640.0 1020.0 0.04 -0.0775 -0.5072 1404864 TimTec1_000131 OCCN(CCO)Cc1c(O)ccc2occ(C(=O)c3cccs3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F22 compound treatment 91360.0 -21200.0 -0.82 167720.0 32100.0 1.2 0.271 0.1858 1413355 TimTec1_000132 CSC1=NC2(CCCCC2)NC3=C1CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F23 mock treatment 112000.0 -534.0 -0.02 142760.0 7140.0 0.27 0.1749 0.6505 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 F24 mock treatment 100560.0 -12000.0 -0.46 139000.0 3380.0 0.13 -0.2388 -0.4958 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G01 compound treatment 65160.0 -47400.0 -1.84 116040.0 -19600.0 -0.73 -1.8193 -0.9191 1746897 TimTec1_000133 CC1Cc2ccccc2N1C(=O)c3cccc(n3)C(=O)N4C(C)Cc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G02 compound treatment 7840.0 -105000.0 -4.06 11040.0 -125000.0 -4.68 -6.1786 -0.9975 1210571 TimTec1_000134 CCOC(=O)C1(C#N)C(C=C(C(=C1N)C#N)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G03 compound treatment 61360.0 -51200.0 -1.99 118680.0 -16900.0 -0.64 -1.8535 -0.889 1738871 TimTec1_000135 O=C(C1CC1(c2ccccc2)c3ccccc3)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G04 compound treatment 61600.0 -50900.0 -1.98 127200.0 -8420.0 -0.32 -1.6208 -0.8099 1495985 TimTec1_000136 CC(C)Cc1cc(c(C#N)c(N)n1)c2cccc(Br)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G05 compound treatment 108240.0 -4290.0 -0.17 127480.0 -8140.0 -0.31 -0.3338 -0.9594 1728047 TimTec1_000137 CC(C)(C)c1cc(CCC(=O)NCCN)cc(c1O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G06 compound treatment 116040.0 3510.0 0.14 154960.0 19300.0 0.73 0.6095 0.8253 1006115 TimTec1_000138 CCN(CC)C1CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G07 compound treatment 64640.0 -47900.0 -1.86 75680.0 -59900.0 -2.25 -2.9047 -0.9955 1442213 TimTec1_000139 CN(C)c1nc(Cl)nc(n1)N(CN2C(=O)c3ccccc3C2=O)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G08 compound treatment 120160.0 7630.0 0.3 134640.0 -979.0 -0.04 0.1833 0.6146 1391498 TimTec1_000140 Cc1nc2n(C)c(=O)n(C)c(=O)c2cc1C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G09 compound treatment 108640.0 -3890.0 -0.15 148720.0 13100.0 0.49 0.2409 0.4682 1225682 TimTec1_000141 CC(C)Nc1nc(NC(C)C)nc(n1)N(C)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G10 compound treatment 9800.0 -103000.0 -3.99 13280.0 -122000.0 -4.59 -6.0653 -0.9975 1485808 TimTec1_000142 Cc1cccc(C[N+](C)(C)CCC(=O)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G11 compound treatment 110440.0 -2090.0 -0.08 134120.0 -1500.0 -0.06 -0.0972 -0.9839 1186157 TimTec1_000143 CC12CCCCC2=NC(N1O)c3ccccc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G12 compound treatment 111600.0 -934.0 -0.04 137840.0 2220.0 0.08 0.0333 0.3667 1025931 TimTec1_000144 Cc1ccc(cc1)S(=O)(=O)NCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G13 compound treatment 14800.0 -97700.0 -3.79 24280.0 -111000.0 -4.18 -5.6362 -0.9988 1323961 TimTec1_000145 S=C(CC(=S)N1CCOCC1)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G14 compound treatment 118480.0 5950.0 0.23 131640.0 -3980.0 -0.15 0.0576 0.2094 3209861 TimTec1_000146 CC(=O)NC1CCCCc2sccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G15 compound treatment 115840.0 3310.0 0.13 132760.0 -2860.0 -0.11 0.0148 0.0888 1288570 TimTec1_000147 CCCC(CCC)c1nc2ccncc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G16 compound treatment 98880.0 -13700.0 -0.53 113520.0 -22100.0 -0.83 -0.9611 -0.9766 3209862 TimTec1_000148 OC1=C(C2C3C(CCCC3=O)Oc4ccccc24)C(=O)CCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G17 compound treatment 38160.0 -74400.0 -2.89 36320.0 -99300.0 -3.73 -4.6758 -0.992 3081632 TimTec1_000149 OC(=O)CCC/N=C(\c1ccc(Cl)cc1)/c2cc(F)ccc2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G18 compound treatment 54560.0 -58000.0 -2.25 59680.0 -75900.0 -2.85 -3.6059 -0.9931 1713094 TimTec1_000150 CN(C)Cc1c(O)ccc2occ(C(=O)c3cccc(Br)c3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G19 compound treatment 119800.0 7270.0 0.28 139120.0 3500.0 0.13 0.2923 0.9396 3081667 TimTec1_000151 CCCC1CC(C)(OC1=O)C(=O)C[n+]2cccc(c2)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G20 compound treatment 93200.0 -19300.0 -0.75 96800.0 -38800.0 -1.46 -1.5606 -0.9524 1405391 TimTec1_000152 COc1ccc(OC)c(c1)C(=O)c2coc3ccc(O)cc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G21 compound treatment 126400.0 13900.0 0.54 136480.0 861.0 0.03 0.4033 0.7482 3081670 TimTec1_000153 CC(C)C1(CN2CC/3CN(C1)CC2)\C3=N/N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G22 compound treatment 75720.0 -36800.0 -1.43 94320.0 -41300.0 -1.55 -2.106 -0.9992 1185154 TimTec1_000154 CCOC(=O)Cn1c(C)c(Sc2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G23 mock treatment 112400.0 -134.0 -0.01 138600.0 2980.0 0.11 0.0755 0.6736 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 G24 mock treatment 106080.0 -6450.0 -0.25 128000.0 -7620.0 -0.29 -0.3793 -0.9978 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H01 compound treatment 114200.0 1670.0 0.06 130040.0 -5580.0 -0.21 -0.1023 -0.467 1114526 TimTec1_000155 NC(=O)c1ccccc1C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H02 compound treatment 108120.0 -4410.0 -0.17 146240.0 10600.0 0.4 0.1608 0.3706 3209863 TimTec1_000156 CC(C)c1ccc(cc1)C(C)(C)CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H03 compound treatment 117120.0 4590.0 0.18 146480.0 10900.0 0.41 0.4141 0.9309 1440514 TimTec1_000157 COc1ccccc1OCCN2CCN(CC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H04 compound treatment 112360.0 -174.0 -0.01 135120.0 -499.0 -0.02 -0.018 -0.9049 3081674 TimTec1_000158 Cc1c(/C=C/c2ccc(Cl)cc2Cl)c(=O)n(c3ccccc3)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H05 compound treatment 137840.0 25300.0 0.98 150360.0 14700.0 0.55 1.0855 0.9632 3209864 TimTec1_000159 COc1ccc(Br)c2OCCOc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H06 compound treatment 10600.0 -102000.0 -3.96 37880.0 -97700.0 -3.67 -5.3905 -0.9993 3209865 TimTec1_000160 COc1ccc(NC(=O)CC(=O)CSc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H07 compound treatment 99360.0 -13200.0 -0.51 134760.0 -859.0 -0.03 -0.3842 -0.7502 1282382 TimTec1_000161 CN1CCN(Cc2c(C#N)c3ccccc3n2C)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H08 compound treatment 112680.0 146.0 0.01 144720.0 9100.0 0.34 0.2456 0.7188 1156260 TimTec1_000162 O=C(CSc1nc2ccccc2o1)Nc3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H09 compound treatment 122520.0 9990.0 0.39 138800.0 3180.0 0.12 0.3584 0.884 1296268 TimTec1_000163 Cn1c(CN2CCOCC2)c(C#N)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H10 compound treatment 108920.0 -3610.0 -0.14 122600.0 -13000.0 -0.49 -0.4446 -0.8747 1566355 TimTec1_000164 C1CCC(CC1)Nc2c(nnn2C3CCCCC3)c4ccn[nH]4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H11 compound treatment 122280.0 9750.0 0.38 136320.0 701.0 0.03 0.286 0.7545 3081679 TimTec1_000165 CNC(=O)CCc1cc2ccccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H12 compound treatment 124080.0 11500.0 0.45 143280.0 7660.0 0.29 0.5201 0.977 1429944 TimTec1_000166 NC(=S)c1cnc2ccccn2c1=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H13 compound treatment 105600.0 -6930.0 -0.27 119720.0 -15900.0 -0.6 -0.6122 -0.9353 1210033 TimTec1_000167 O=C(CCN1CCN(CC1)c2ccccc2)Nc3nccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H14 compound treatment 100000.0 -12500.0 -0.49 110560.0 -25100.0 -0.94 -1.0089 -0.9529 3209866 TimTec1_000168 FC(F)(F)c1[nH]n(c2nc3ccccc3s2)c(=O)c1/C=N/CCN4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H15 compound treatment 95920.0 -16600.0 -0.64 108400.0 -27200.0 -1.02 -1.1782 -0.9754 3081684 TimTec1_000169 COc1ccc(/C=N/c2oc(C)c(C)c2C#N)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H16 compound treatment 20560.0 -92000.0 -3.57 27000.0 -109000.0 -4.08 -5.406 -0.9978 3209867 TimTec1_000170 C[n+]1c(COc2ccccc2O)sc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H17 compound treatment 57360.0 -55200.0 -2.14 66080.0 -69500.0 -2.61 -3.3592 -0.9952 1912978 TimTec1_000171 CC(=O)N1c2ccccc2C(C)(CC1(C)C)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H18 compound treatment 123480.0 10900.0 0.42 139560.0 3940.0 0.15 0.4049 0.9003 3081687 TimTec1_000172 Cn1ccnc1C(=O)Oc2ccccc2F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H19 compound treatment 42960.0 -69600.0 -2.7 63960.0 -71700.0 -2.69 -3.8106 -1.0 1280653 TimTec1_000173 CC1=CC(C)(C)N(c2ccccc12)S(=O)(=O)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H20 compound treatment 133000.0 20500.0 0.79 144640.0 9020.0 0.34 0.8009 0.9278 3209868 TimTec1_000174 O=c1[nH]c2ccc(/N=C/c3ccc4OCOc4c3)cc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H21 compound treatment 121080.0 8550.0 0.33 125040.0 -10600.0 -0.4 -0.0463 -0.0894 3081729 TimTec1_000175 Nc1no[n+]([O-])c1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H22 compound treatment 104320.0 -8210.0 -0.32 137800.0 2180.0 0.08 -0.1675 -0.5089 3081731 TimTec1_000176 CCOc1ccc2S/C(=C/NC(C)CC)/C(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H23 mock treatment 113040.0 506.0 0.02 145200.0 9580.0 0.36 0.2682 0.7446 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 H24 mock treatment 103640.0 -8890.0 -0.35 127320.0 -8300.0 -0.31 -0.4642 -0.9987 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I01 compound treatment 84960.0 -27600.0 -1.07 127360.0 -8260.0 -0.31 -0.9757 -0.8759 1160113 TimTec1_000177 Cc1ccccc1OCC(=O)Nc2ccc3nn(nc3c2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I02 compound treatment 91400.0 -21100.0 -0.82 107840.0 -27800.0 -1.04 -1.317 -0.9929 1912584 TimTec1_000178 Nc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I03 compound treatment 104120.0 -8410.0 -0.33 134520.0 -1100.0 -0.04 -0.26 -0.7901 3081734 TimTec1_000179 COC(=O)CCC(=O)Nc1nccs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I04 compound treatment 78840.0 -33700.0 -1.31 126720.0 -8900.0 -0.33 -1.1606 -0.8601 1175548 TimTec1_000180 CC(=O)Nc1nc(cc(c1C#N)c2ccccc2)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I05 compound treatment 109160.0 -3370.0 -0.13 120320.0 -15300.0 -0.57 -0.4986 -0.8466 1060191 TimTec1_000181 S=C1N(CN2CCCCC2)CCN1CN3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I06 compound treatment 118640.0 6110.0 0.24 138720.0 3100.0 0.12 0.2498 0.9465 3209869 TimTec1_000182 CC[N+](C)(CC)Cc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I07 compound treatment 116080.0 3550.0 0.14 131880.0 -3740.0 -0.14 -0.0019 -0.0098 3209870 TimTec1_000183 Cc1cc(NN)nc(SCC(=O)NN)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I08 compound treatment 118120.0 5590.0 0.22 124560.0 -11100.0 -0.42 -0.1402 -0.2995 1289525 TimTec1_000184 C[N+]1(CC(O)C[N+]2(C)CCCCC2)CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I09 compound treatment 13800.0 -98700.0 -3.83 19200.0 -116000.0 -4.37 -5.7985 -0.9979 1505713 TimTec1_000185 C1=C(N=C2C=Cc3nonc3C12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I10 compound treatment 106680.0 -5850.0 -0.23 121240.0 -14400.0 -0.54 -0.5422 -0.926 1080215 TimTec1_000186 OP(=O)(Nc1ccccc1)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I11 compound treatment 99600.0 -12900.0 -0.5 130960.0 -4660.0 -0.17 -0.4785 -0.9004 3209871 TimTec1_000187 Cc1c(Br)c(nn1CC(=O)N)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I12 compound treatment 134120.0 21600.0 0.84 137160.0 1540.0 0.06 0.6331 0.7542 1668354 TimTec1_000188 O=C(N1CCCCC1)c2ccccc2C(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I13 compound treatment 134320.0 21800.0 0.85 130600.0 -5020.0 -0.19 0.4645 0.5364 1230919 TimTec1_000189 CN(C)CCNc1nc(no1)c2noc(NCCN(C)C)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I14 compound treatment 125680.0 13100.0 0.51 125160.0 -10500.0 -0.39 0.0831 0.1291 1641088 TimTec1_000190 C[N+]1(CC(O)CN2CCCC2=O)CCCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I15 compound treatment 112000.0 -534.0 -0.02 134760.0 -859.0 -0.03 -0.0374 -0.9772 1479834 TimTec1_000191 CC1(C)CC(CC(C)(C)N1)NC(=O)N2c3ccccc3CCc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I16 compound treatment 125360.0 12800.0 0.5 131480.0 -4140.0 -0.16 0.2421 0.4643 3209872 TimTec1_000192 CCOC(=O)C1(C#N)C(C#N)(C(=O)OCC)C1(C#N)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I17 compound treatment 45240.0 -67300.0 -2.61 54040.0 -81600.0 -3.06 -4.0113 -0.9969 1350657 TimTec1_000193 COc1ccc2NC(C)(C)c3ssc(=S)c3-c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I18 compound treatment 37520.0 -75000.0 -2.91 49080.0 -86500.0 -3.25 -4.3547 -0.9985 1439817 TimTec1_000194 CC(=O)Oc1ccc2occ(C(=O)c3cc4ccccc4o3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I19 compound treatment 113200.0 666.0 0.03 120640.0 -15000.0 -0.56 -0.3792 -0.6739 1619809 TimTec1_000195 Nc1nc(cc(c1C#N)c2ccccc2Cl)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I20 compound treatment 8360.0 -104000.0 -4.04 9360.0 -126000.0 -4.74 -6.2089 -0.9969 1402303 TimTec1_000196 CN(C)CCC(=O)c1coc2ccc(OC(=O)C)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I21 compound treatment 66640.0 -45900.0 -1.78 95400.0 -40200.0 -1.51 -2.3265 -0.9966 3209873 TimTec1_000197 C/C(=N\n1nnnc1Nc2ccccc2)/c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I22 compound treatment 110400.0 -2130.0 -0.08 136400.0 781.0 0.03 -0.0378 -0.4304 1447918 TimTec1_000198 COC(=O)CCC(=O)c1cc2cc(Br)ccc2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I23 mock treatment 123880.0 11300.0 0.44 136920.0 1300.0 0.05 0.3458 0.7808 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 I24 mock treatment 107320.0 -5210.0 -0.2 129720.0 -5900.0 -0.22 -0.2996 -0.999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J01 compound treatment 101960.0 -10600.0 -0.41 133200.0 -2420.0 -0.09 -0.3543 -0.8432 1078582 TimTec1_000199 NC(=O)c1ccc2ccccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J02 compound treatment 104960.0 -7570.0 -0.29 149520.0 13900.0 0.52 0.1611 0.2691 1032512 TimTec1_000200 O=C1N(CNc2ccccc2)C(=O)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J03 compound treatment 101240.0 -11300.0 -0.44 127560.0 -8060.0 -0.3 -0.5237 -0.9836 1725358 TimTec1_000201 Cc1ccc(cc1)S(=O)(=O)CCN2CCN(CC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J04 compound treatment 134280.0 21700.0 0.84 135680.0 61.4 0.0 0.5983 0.709 1122981 TimTec1_000202 O=C1NC(=O)c2cc(ccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J05 compound treatment 128800.0 16300.0 0.63 147840.0 12200.0 0.46 0.7706 0.9877 1020688 TimTec1_000203 Cc1ccc(NC(=O)CC(=O)Nc2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J06 compound treatment 109080.0 -3450.0 -0.13 147240.0 11600.0 0.44 0.2137 0.4683 1386865 TimTec1_000204 COC(=O)c1ccc(NC(=O)COc2cccc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J07 compound treatment 129080.0 16500.0 0.64 138240.0 2620.0 0.1 0.5235 0.8061 1498066 TimTec1_000205 CC(=O)Nc1c(oc2ccccc12)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J08 compound treatment 130960.0 18400.0 0.71 134120.0 -1500.0 -0.06 0.4658 0.6495 1326858 TimTec1_000206 CN1CCc2c(C1)c(nc3[nH]nc(N)c23)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J09 compound treatment 67640.0 -44900.0 -1.74 80840.0 -54800.0 -2.06 -2.6855 -0.9966 1734489 TimTec1_000207 Cn1c(CSCc2ccccc2)c(C#N)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J10 compound treatment 137320.0 24800.0 0.96 128000.0 -7620.0 -0.29 0.4778 0.4763 3209874 TimTec1_000208 O/N=C\1/C2CN3CC1(Cc4ccccc4)CN(C2)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J11 compound treatment 102320.0 -10200.0 -0.4 105840.0 -29800.0 -1.12 -1.0705 -0.9028 3081797 TimTec1_000209 S(c1ccccn1)c2ncnc3c4ccccc4oc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J12 compound treatment 101640.0 -10900.0 -0.42 119840.0 -15800.0 -0.59 -0.7176 -0.9863 3209875 TimTec1_000210 CCOC(=O)[C@@]1(C#N)[C@H]([C@@H](N2C=C(C=C[C@H]21)C(=O)N)C(=O)N)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J13 compound treatment 103040.0 -9490.0 -0.37 110840.0 -24800.0 -0.93 -0.9181 -0.9178 3081799 TimTec1_000211 C(Sc1ncnc2c3ccccc3oc12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J14 compound treatment 71760.0 -40800.0 -1.58 89400.0 -46200.0 -1.73 -2.3453 -0.9989 3081800 TimTec1_000212 FC(F)(F)c1[nH]n(c2nc3ccccc3s2)c(=O)c1/C=N/Cc4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J15 compound treatment 104760.0 -7770.0 -0.3 101600.0 -34000.0 -1.28 -1.1161 -0.8507 1498770 TimTec1_000213 COc1cc(OC)cc(c1)C(=O)N2CCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J16 compound treatment 107000.0 -5530.0 -0.21 158000.0 22400.0 0.84 0.4422 0.51 1358111 TimTec1_000214 Oc1ccccc1OCC(=O)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J17 compound treatment 118320.0 5790.0 0.22 130840.0 -4780.0 -0.18 0.0319 0.1111 1091978 TimTec1_000215 CCOC(=O)CN=C(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J18 compound treatment 43800.0 -68700.0 -2.67 57080.0 -78500.0 -2.95 -3.9701 -0.9988 1917358 TimTec1_000216 CN1CCN(CC(O)COCCC2(CC3CC4CC(C3)C2)C4)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J19 compound treatment 81080.0 -31500.0 -1.22 112320.0 -23300.0 -0.87 -1.4813 -0.9866 1066363 TimTec1_000217 COc1ccc2NC(C)(C)C=C(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J20 compound treatment 103080.0 -9450.0 -0.37 129680.0 -5940.0 -0.22 -0.417 -0.9715 1921867 TimTec1_000218 On1c(nc-2c1CCc3c2no[n+]3[O-])c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J21 compound treatment 110560.0 -1970.0 -0.08 123400.0 -12200.0 -0.46 -0.3784 -0.8139 3081805 TimTec1_000219 Nc1c(no[n+]1[O-])C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J22 compound treatment 107880.0 -4650.0 -0.18 117920.0 -17700.0 -0.66 -0.5974 -0.8678 1879059 TimTec1_000220 CNC(=O)N(Cc1cccnc1)Cc2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J23 mock treatment 119120.0 6590.0 0.26 131400.0 -4220.0 -0.16 0.0687 0.2287 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 J24 mock treatment 105680.0 -6850.0 -0.27 152600.0 17000.0 0.64 0.2626 0.3803 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K01 compound treatment 114480.0 1950.0 0.08 119640.0 -16000.0 -0.6 -0.3707 -0.6132 1259801 TimTec1_000221 CS(=O)(=O)c1ccc2nc(NC(=O)C3CCCO3)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K02 compound treatment 27800.0 -84700.0 -3.29 42440.0 -93200.0 -3.5 -4.7976 -0.9995 1151146 TimTec1_000222 Nc1c(C#N)c(c2ccccc2)c3CCCCc3c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K03 compound treatment 65520.0 -47000.0 -1.82 95000.0 -40600.0 -1.52 -2.3678 -0.996 1392387 TimTec1_000223 Brc1ccc(o1)C(=O)Nc2ccc3OCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K04 compound treatment 112880.0 346.0 0.01 135080.0 -539.0 -0.02 -0.0048 -0.1975 1275980 TimTec1_000224 Clc1ccc(OCC(=O)NCC=C)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K05 compound treatment 73680.0 -38900.0 -1.51 104720.0 -30900.0 -1.16 -1.886 -0.9916 1285366 TimTec1_000225 Cc1cccc(CN2CCN(Cc3cccc(C)c3O)CC2)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K06 compound treatment 116880.0 4350.0 0.17 136840.0 1220.0 0.05 0.1517 0.8678 3081809 TimTec1_000226 Cc1cc(C)nc(SCC(=O)NN)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K07 compound treatment 125960.0 13400.0 0.52 135080.0 -539.0 -0.02 0.3541 0.6792 1584109 TimTec1_000227 NNC(=O)C1CC2CC1CC2C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K08 compound treatment 107360.0 -5170.0 -0.2 120400.0 -15200.0 -0.57 -0.5458 -0.9016 1914424 TimTec1_000228 C(=N/C(\N=C\c1ccccc1)c2ccccc2)\c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K09 compound treatment 107280.0 -5250.0 -0.2 109040.0 -26600.0 -1.0 -0.8495 -0.8344 3081861 TimTec1_000229 COC(=O)c1ccc(NC(=S)NC(=O)N2CCOCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K10 compound treatment 126400.0 13900.0 0.54 131400.0 -4220.0 -0.16 0.2685 0.4787 3209999 TimTec1_000230 CC(=O)OC1COC(NC(=S)Oc2ccccc2)C(OC(=O)C)C1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K11 compound treatment 110720.0 -1810.0 -0.07 126560.0 -9060.0 -0.34 -0.2902 -0.8358 3081863 TimTec1_000231 CCOC(=O)Cn1nc(cc1C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K12 compound treatment 26480.0 -86100.0 -3.34 51640.0 -84000.0 -3.15 -4.5897 -0.9996 3210000 TimTec1_000232 COc1ccc(/C=C/C(=O)OC2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K13 compound treatment 7680.0 -105000.0 -4.07 8600.0 -127000.0 -4.77 -6.2477 -0.9969 3081865 TimTec1_000233 c1ccc(cc1)c2cnc3nonc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K14 compound treatment 18960.0 -93600.0 -3.63 70640.0 -65000.0 -2.44 -4.2917 -0.9813 1474168 TimTec1_000234 COc1ccc(CCN(C)C(=S)NN)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K15 compound treatment 111680.0 -854.0 -0.03 106720.0 -28900.0 -1.08 -0.7904 -0.7284 1445690 TimTec1_000235 OC(=O)c1cc2cccc(c2cc1O)S(=O)(=O)N3CCCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K16 compound treatment 56840.0 -55700.0 -2.16 56400.0 -79200.0 -2.97 -3.6304 -0.9877 1033126 TimTec1_000236 Cc1ccc(cc1)S(=O)(=O)Nc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K17 compound treatment 36880.0 -75700.0 -2.94 40400.0 -95200.0 -3.57 -4.6026 -0.9952 1183681 TimTec1_000237 COc1cc(NC(=O)Cc2ccc(F)cc2)cc(c1)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K18 compound treatment 108360.0 -4170.0 -0.16 119320.0 -16300.0 -0.61 -0.5471 -0.8645 1604299 TimTec1_000238 COc1cc2c(NC(=O)C)c(CN(C)C)oc2c(Cl)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K19 compound treatment 64440.0 -48100.0 -1.87 76720.0 -58900.0 -2.21 -2.8826 -0.9964 3210001 TimTec1_000239 NS(=O)(=O)c1ccc(NC=C2C(=O)c3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K20 compound treatment 7880.0 -105000.0 -4.06 7840.0 -128000.0 -4.8 -6.2624 -0.9966 3081870 TimTec1_000240 CCOC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K21 compound treatment 107360.0 -5170.0 -0.2 112600.0 -23000.0 -0.86 -0.7528 -0.8488 3210002 TimTec1_000241 S=c1n(CN(Cc2ccccc2)Cc3ccccc3)nnn1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K22 compound treatment 7640.0 -105000.0 -4.07 8200.0 -127000.0 -4.78 -6.2594 -0.9968 1023688 TimTec1_000242 CN(C)CCC(=O)c1ccco1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K23 mock treatment 101320.0 -11200.0 -0.44 124960.0 -10700.0 -0.4 -0.5905 -0.9991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 K24 mock treatment 109480.0 -3050.0 -0.12 116680.0 -18900.0 -0.71 -0.5864 -0.8137 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L01 compound treatment 119840.0 7310.0 0.28 129840.0 -5780.0 -0.22 0.0471 0.1319 1264988 TimTec1_000243 COc1cc(N)c(Cl)cc1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L02 compound treatment 120960.0 8430.0 0.33 133800.0 -1820.0 -0.07 0.1829 0.5477 1706058 TimTec1_000244 CC(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccccc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L03 compound treatment 122600.0 10100.0 0.39 127600.0 -8020.0 -0.3 0.0634 0.1285 1357677 TimTec1_000245 CNC(=O)c1cnc2cc(Cl)ccc2c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L04 compound treatment 118760.0 6230.0 0.24 122200.0 -13400.0 -0.5 -0.1853 -0.3317 1569209 TimTec1_000246 O=S(=O)(NC1c2ccccc2Oc3ccccc13)c4ccc5ccccc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L05 compound treatment 112320.0 -214.0 -0.01 120760.0 -14900.0 -0.56 -0.4002 -0.7175 1015215 TimTec1_000247 COc1ccc(NC(=O)CC(=O)Nc2ccc(OC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L06 compound treatment 118120.0 5590.0 0.22 129760.0 -5860.0 -0.22 -0.0022 -0.0072 1490465 TimTec1_000248 COc1ccc(SCC(=O)Nc2ccccn2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L07 compound treatment 12880.0 -99700.0 -3.87 115080.0 -20500.0 -0.77 -3.2792 -0.8317 1204062 TimTec1_000249 CSc1c(CC(=O)NN)n(C)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L08 compound treatment 135200.0 22700.0 0.88 137160.0 1540.0 0.06 0.6628 0.752 1235682 TimTec1_000250 CCc1nc2[nH]nc(N)c2c3CC(C)(C)OCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L09 compound treatment 90400.0 -22100.0 -0.86 94960.0 -40700.0 -1.53 -1.6863 -0.963 3081877 TimTec1_000251 O=C(/C=C/N1CCOCC1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L10 compound treatment 123080.0 10500.0 0.41 111600.0 -24000.0 -0.9 -0.3481 -0.3516 3210003 TimTec1_000252 C[n+]1ccc(/C=C/c2cccs2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L11 compound treatment 101200.0 -11300.0 -0.44 109800.0 -25800.0 -0.97 -0.9961 -0.9361 1338690 TimTec1_000253 CN(C)Cc1c(O)ccc2occ(C(=O)c3ccc(C)cc3)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L12 compound treatment 86400.0 -26100.0 -1.01 88680.0 -46900.0 -1.76 -1.9627 -0.9656 1654307 TimTec1_000254 CC1(C)Cc2c(C#N)c3nc(cnn3c2CO1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L13 compound treatment 9480.0 -103000.0 -4.0 9520.0 -126000.0 -4.73 -6.1739 -0.9965 1245793 TimTec1_000255 CCc1oc2ccccc2c1C(=O)c3ccc(OC(=O)C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L14 compound treatment 118000.0 5470.0 0.21 122760.0 -12900.0 -0.48 -0.1913 -0.3629 3081942 TimTec1_000256 CN(C)S(=O)(=O)c1ccc(N/C=C\2/C(=C(C#N)C(=O)N(C)C2=O)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L15 compound treatment 9800.0 -103000.0 -3.99 8520.0 -127000.0 -4.77 -6.1917 -0.996 1570064 TimTec1_000257 Cc1ccc2nc(Nc3ccccc3)cc(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L16 compound treatment 118400.0 5870.0 0.23 110120.0 -25500.0 -0.96 -0.5158 -0.5243 1509985 TimTec1_000258 C=CCC1CCCCC1NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L17 compound treatment 72720.0 -39800.0 -1.54 76400.0 -59200.0 -2.22 -2.6639 -0.9842 1455868 TimTec1_000259 COc1cccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L18 compound treatment 90160.0 -22400.0 -0.87 95840.0 -39800.0 -1.49 -1.6695 -0.9667 3210004 TimTec1_000260 Fc1ccc(/N=C/c2ccc(OC(=O)c3ccco3)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L19 compound treatment 64520.0 -48000.0 -1.86 76720.0 -58900.0 -2.21 -2.8804 -0.9964 1369950 TimTec1_000261 CCOc1ccc2N(C)C(C)(C)c3ssc(=S)c3-c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L20 compound treatment 16880.0 -95700.0 -3.71 23760.0 -112000.0 -4.2 -5.593 -0.9981 3210005 TimTec1_000262 NC(=O)[C@H]1[C@H](c2ccc(F)cc2)C(C#N)(C#N)[C@H]3N1C=Cc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L21 compound treatment 12480.0 -100000.0 -3.88 37560.0 -98100.0 -3.68 -5.3474 -0.9996 1298997 TimTec1_000263 CCOC(=O)c1c(CNc2cccc(c2)C(=O)N)n(C)c3cc(Br)c(OC(=O)C)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L22 compound treatment 105640.0 -6890.0 -0.27 110440.0 -25200.0 -0.94 -0.8573 -0.873 1677367 TimTec1_000264 O=C(Nc1c(cnn1c2ccccc2)C(=O)N3CCCCC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L23 mock treatment 109680.0 -2850.0 -0.11 115720.0 -19900.0 -0.75 -0.6064 -0.8032 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 L24 mock treatment 99000.0 -13500.0 -0.53 119040.0 -16600.0 -0.62 -0.8113 -0.9964 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M01 compound treatment 106280.0 -6250.0 -0.24 128800.0 -6820.0 -0.26 -0.3525 -0.9996 1321921 TimTec1_000265 OC1(N(C(=O)Nc2ccccc21)c3ccccc3)C(=O)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M02 compound treatment 58960.0 -53600.0 -2.08 67400.0 -68200.0 -2.56 -3.2803 -0.9947 3081949 TimTec1_000266 CCC1(C)C/C(=C\C)/C(=C(N)C1(C#N)C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M03 compound treatment 104200.0 -8330.0 -0.32 112200.0 -23400.0 -0.88 -0.8501 -0.9078 1666559 TimTec1_000267 COc1cc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccco3)cc2)ncn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M04 compound treatment 102880.0 -9650.0 -0.37 123320.0 -12300.0 -0.46 -0.5913 -0.9946 1006470 TimTec1_000268 C[N+](C)(Cc1ccccc1)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M05 compound treatment 72680.0 -39900.0 -1.55 83320.0 -52300.0 -1.96 -2.4814 -0.993 3210006 TimTec1_000269 O=S(N1CCOCC1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M06 compound treatment 97160.0 -15400.0 -0.6 106440.0 -29200.0 -1.1 -1.1962 -0.9592 3081952 TimTec1_000270 S=C(Nc1ccccc1)N=S(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M07 compound treatment 119080.0 6550.0 0.25 112800.0 -22800.0 -0.86 -0.426 -0.4769 1489996 TimTec1_000271 COC1OC2COC(OC2CC1O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M08 compound treatment 114080.0 1550.0 0.06 103360.0 -32300.0 -1.21 -0.8137 -0.6712 3210007 TimTec1_000272 O=C(c1ccccc1)c2cc[n+](Cc3ccccn3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M09 compound treatment 121720.0 9190.0 0.36 123560.0 -12100.0 -0.45 -0.068 -0.118 3210008 TimTec1_000273 Cc1ccc(/C=C/C(=O)NC(=S)N2CCN(CC2)c3ccc(F)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M10 compound treatment 119000.0 6470.0 0.25 126320.0 -9300.0 -0.35 -0.0694 -0.1614 1433383 TimTec1_000274 CCCOC(=S)NC1OCC(O)C(O)C1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M11 compound treatment 42520.0 -70000.0 -2.72 58960.0 -76700.0 -2.88 -3.9553 -0.9996 1720341 TimTec1_000275 O=C(Nc1ccc(cc1)c2ccccc2)C3CC3c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M12 compound treatment 106080.0 -6450.0 -0.25 136560.0 941.0 0.04 -0.1521 -0.6014 3081955 TimTec1_000276 COc1ccc(/C=C/C(=O)NC(C)(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M13 compound treatment 115440.0 2910.0 0.11 121240.0 -14400.0 -0.54 -0.3019 -0.5475 1475730 TimTec1_000277 CCOC(=O)c1nonc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M14 compound treatment 10160.0 -102000.0 -3.97 10560.0 -125000.0 -4.69 -6.1276 -0.9966 3082017 TimTec1_000278 Clc1ccc(cc1)C2=NN=C(SC2)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M15 compound treatment 98360.0 -14200.0 -0.55 104840.0 -30800.0 -1.16 -1.2057 -0.9424 1344248 TimTec1_000279 CCN(CC)CCC(O)(C1CCCCC1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M16 compound treatment 120000.0 7470.0 0.29 107240.0 -28400.0 -1.07 -0.5483 -0.4967 1532600 TimTec1_000280 Cc1nc2ccccc2cc1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M17 compound treatment 100440.0 -12100.0 -0.47 100560.0 -35100.0 -1.32 -1.2622 -0.9035 3210120 TimTec1_000281 COc1ccc(cc1)c2cc(n3nc(cc3n2)C(=O)NCCN4CCOCC4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M18 compound treatment 84440.0 -28100.0 -1.09 78440.0 -57200.0 -2.15 -2.2882 -0.9507 1325986 TimTec1_000282 Cc1ccc(o1)C(=O)c2coc3ccc(O)cc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M19 compound treatment 110360.0 -2170.0 -0.08 109920.0 -25700.0 -0.96 -0.7417 -0.766 3210121 TimTec1_000283 OCC(CO)(CO)NC=C1C(=O)c2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M20 compound treatment 95040.0 -17500.0 -0.68 90080.0 -45500.0 -1.71 -1.6885 -0.9182 1295715 TimTec1_000284 OC(=O)CCCc1cc2cc(Br)ccc2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M21 compound treatment 37880.0 -74700.0 -2.9 16320.0 -119000.0 -4.48 -5.2143 -0.9778 3210122 TimTec1_000285 Brc1ccc(/N=C(\c2ccccc2)/c3ccncc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M22 compound treatment 105400.0 -7130.0 -0.28 102560.0 -33100.0 -1.24 -1.0731 -0.8441 1536799 TimTec1_000286 Clc1cccc(NC(=O)NCCN2CCCCC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M23 mock treatment 111280.0 -1250.0 -0.05 116480.0 -19100.0 -0.72 -0.5423 -0.7533 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 M24 mock treatment 109680.0 -2850.0 -0.11 119360.0 -16300.0 -0.61 -0.5098 -0.822 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N01 compound treatment 102080.0 -10500.0 -0.41 121520.0 -14100.0 -0.53 -0.661 -0.9914 1530149 TimTec1_000287 CCCCN1CCC(CC1)(Nc2ccccc2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N02 compound treatment 135560.0 23000.0 0.89 109080.0 -26500.0 -1.0 -0.0726 -0.0542 1146434 TimTec1_000288 O=C(COC(=O)c1ccc(cc1)N2C(=O)c3ccccc3C2=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N03 compound treatment 95120.0 -17400.0 -0.68 76160.0 -59500.0 -2.23 -2.0557 -0.8817 1353615 TimTec1_000289 CCOC(=O)c1c(CN(CC)CC)oc2ccc(OC)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N04 compound treatment 76720.0 -35800.0 -1.39 55400.0 -80200.0 -3.01 -3.1115 -0.9383 1022729 TimTec1_000290 O=C1N(C2c3ccccc3Oc4ccccc24)C(=O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N05 compound treatment 122880.0 10300.0 0.4 115760.0 -19900.0 -0.75 -0.2432 -0.2872 3082023 TimTec1_000291 O=C1N(/N=C/c2ccccc2)C(=O)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N06 compound treatment 119560.0 7030.0 0.27 115040.0 -20600.0 -0.77 -0.3534 -0.4314 3210123 TimTec1_000292 O=C(CSc1ccccn1)Nc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N07 compound treatment 127040.0 14500.0 0.56 110040.0 -25600.0 -0.96 -0.2808 -0.2524 3082025 TimTec1_000293 Cc1cc(n[nH]1)c2cc(C)[nH]n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N08 compound treatment 132040.0 19500.0 0.76 124680.0 -10900.0 -0.41 0.2449 0.2844 1617345 TimTec1_000294 CN1CCc2c(C1)c(NCCO)nc3[nH]nc(N)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N09 compound treatment 44680.0 -67900.0 -2.63 37320.0 -98300.0 -3.69 -4.4704 -0.9863 1226159 TimTec1_000295 C(Cc1ccncc1)Nc2ccc(OCc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N10 compound treatment 54600.0 -57900.0 -2.25 43480.0 -92100.0 -3.46 -4.0347 -0.9782 3210124 TimTec1_000296 COc1ccc2c(C)nc(N/C(=N/C(=O)C)/N)nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N11 compound treatment 112120.0 -414.0 -0.02 152360.0 16700.0 0.63 0.4329 0.6888 1294429 TimTec1_000297 CC(=O)Nc1c(oc2ccc(Br)cc12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N12 compound treatment 48520.0 -64000.0 -2.48 55080.0 -80500.0 -3.02 -3.8937 -0.9952 3210125 TimTec1_000298 CC1(C)Cc2c(C#N)c(=S)[nH]c(N3CCOCC3)c2CS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N13 compound treatment 79520.0 -33000.0 -1.28 88960.0 -46700.0 -1.75 -2.144 -0.9882 1155921 TimTec1_000299 N#CC(CCN1CCN(CC1)c2ccccc2)(c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N14 compound treatment 116800.0 4270.0 0.17 120400.0 -15200.0 -0.57 -0.2868 -0.4823 1441186 TimTec1_000300 C1CCC(CC1)c2nnc(o2)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N15 compound treatment 116880.0 4350.0 0.17 112920.0 -22700.0 -0.85 -0.4832 -0.5563 3210126 TimTec1_000301 CCC(C)C1=NN(C(=O)c2ccccc2)C(O)(C1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N16 compound treatment 66560.0 -46000.0 -1.78 60320.0 -75300.0 -2.83 -3.2597 -0.9754 3082032 TimTec1_000302 Cc1ccc(cc1)c2ccc(OC(=O)c3ccccc3F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N17 compound treatment 32080.0 -80500.0 -3.12 26160.0 -109000.0 -4.11 -5.1122 -0.9908 1424431 TimTec1_000303 CC1=CC(C)(C)N(Cc2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N18 compound treatment 95160.0 -17400.0 -0.67 86240.0 -49400.0 -1.85 -1.7871 -0.9062 3081117 TimTec1_000304 Fc1ccc(/N=C/c2ccc(OC(=O)c3cccs3)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N19 compound treatment 72160.0 -40400.0 -1.57 63600.0 -72000.0 -2.7 -3.019 -0.9664 3210127 TimTec1_000305 CC(C)C(=O)N1c2ccc(C)cc2-c3c(ssc3=S)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N20 compound treatment 60080.0 -52500.0 -2.04 51000.0 -84600.0 -3.18 -3.6848 -0.9769 3081119 TimTec1_000306 CCOc1cc(/C=C/2\SCOC2=O)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N21 compound treatment 102920.0 -9610.0 -0.37 96920.0 -38700.0 -1.45 -1.2908 -0.8608 1693566 TimTec1_000307 CCOC(=O)c1c(C)n(C)c2ccc(O)c(c12)S(=O)(=O)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N22 compound treatment 83160.0 -29400.0 -1.14 88240.0 -47400.0 -1.78 -2.0633 -0.9769 1465551 TimTec1_000308 Fc1ccc(CC(=O)NC2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N23 mock treatment 115720.0 3190.0 0.12 119560.0 -16100.0 -0.6 -0.3388 -0.5506 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 N24 mock treatment 115160.0 2630.0 0.1 123720.0 -11900.0 -0.45 -0.2437 -0.5321 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O01 compound treatment 110000.0 -2530.0 -0.1 126680.0 -8940.0 -0.34 -0.3067 -0.8774 1586093 TimTec1_000309 OC1(N(C(=O)Nc2ccccc21)c3ccccc3)C(=O)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O02 compound treatment 77960.0 -34600.0 -1.34 68080.0 -67500.0 -2.53 -2.741 -0.9557 1502323 TimTec1_000310 Nc1nc2CCCc2c(c1C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O03 compound treatment 110880.0 -1650.0 -0.06 94040.0 -41600.0 -1.56 -1.1488 -0.7356 3210128 TimTec1_000311 NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)/C=C/c2ccc(F)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O04 compound treatment 108240.0 -4290.0 -0.17 99960.0 -35700.0 -1.34 -1.0641 -0.789 1176923 TimTec1_000312 C[N+](C)(CCC#N)Cc1cccc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O05 compound treatment 9520.0 -103000.0 -4.0 10120.0 -125000.0 -4.71 -6.1569 -0.9967 3081123 TimTec1_000313 S=C(SN1CCOCC1)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O06 compound treatment 135320.0 22800.0 0.88 123280.0 -12300.0 -0.46 0.2977 0.2983 1002693 TimTec1_000314 COC1OC2COC(OC2C(O)C1O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O07 compound treatment 123720.0 11200.0 0.43 106680.0 -28900.0 -1.09 -0.4611 -0.3942 1507393 TimTec1_000315 CCCOC(=S)NC1OCC(OC(=O)C)C(OC(=O)C)C1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O08 compound treatment 147240.0 34700.0 1.35 107040.0 -28600.0 -1.07 0.1938 0.1125 3081125 TimTec1_000316 C(c1ccccc1)c2ccc[n+](Cc3ccccn3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O09 compound treatment 126280.0 13700.0 0.53 111040.0 -24600.0 -0.92 -0.2751 -0.2582 3210129 TimTec1_000317 Cc1cc(C)n(n1)C(=O)COc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O10 compound treatment 107320.0 -5210.0 -0.2 97560.0 -38100.0 -1.43 -1.1531 -0.7993 1676440 TimTec1_000318 CC12CCC3C(CC=C4CC(CCC34C)OC5CCCCO5)C2CCC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O11 compound treatment 112880.0 346.0 0.01 141480.0 5860.0 0.22 0.1651 0.7489 1921096 TimTec1_000319 O=C1NC(=O)C2(COC(OC2)c3ccccc3)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O12 compound treatment 92120.0 -20400.0 -0.79 125840.0 -9780.0 -0.37 -0.8196 -0.9389 3081128 TimTec1_000320 COc1ccc(/C=C/C(=O)NCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O13 compound treatment 114840.0 2310.0 0.09 129800.0 -5820.0 -0.22 -0.0911 -0.3862 3081129 TimTec1_000321 COc1nonc1NC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O14 compound treatment 95680.0 -16900.0 -0.65 145080.0 9460.0 0.36 -0.2113 -0.284 1215803 TimTec1_000322 CN(C)CCSc1nc2ccccc2c(=O)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O15 compound treatment 116520.0 3990.0 0.15 102120.0 -33500.0 -1.26 -0.7797 -0.6155 1134169 TimTec1_000323 COc1ccc(c2nc3nnc(C)n3[nH]2)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O16 compound treatment 86040.0 -26500.0 -1.03 86680.0 -48900.0 -1.84 -2.0257 -0.9624 1165035 TimTec1_000324 CCOC(=O)c1c(CN2CCCCC2)n(c3ccccc3)c4ccc(OC(=O)C)cc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O17 compound treatment 123200.0 10700.0 0.41 112120.0 -23500.0 -0.88 -0.331 -0.3397 3210130 TimTec1_000325 CC(=O)Nc1ccc(/N=C/c2ccc(cc2)N3CCOCC3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O18 compound treatment 122400.0 9870.0 0.38 94880.0 -40700.0 -1.53 -0.8105 -0.5142 1656585 TimTec1_000326 OC(=O)C(Cc1ccsc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O19 compound treatment 128360.0 15800.0 0.61 129920.0 -5700.0 -0.21 0.283 0.4352 3081133 TimTec1_000327 CC1(C)CC(=O)C(=CNC(CO)(CO)CO)C(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O20 compound treatment 104440.0 -8090.0 -0.31 81960.0 -53700.0 -2.01 -1.6461 -0.8076 3210131 TimTec1_000328 CCOC(=O)c1c(CNC(C)C)oc2ccc(OC)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O21 compound treatment 10480.0 -102000.0 -3.96 7280.0 -128000.0 -4.82 -6.2059 -0.9953 3210132 TimTec1_000329 Cc1ccc(C)c(c1)[C@H]2[C@@H](N3C(C=Cc4ccccc34)C2(C#N)C#N)C(=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O22 compound treatment 89040.0 -23500.0 -0.91 99400.0 -36200.0 -1.36 -1.6058 -0.9811 1145302 TimTec1_000330 CCOC(=O)c1c(C)n(C2CCCCC2)c3ccc(O)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O23 mock treatment 117440.0 4910.0 0.19 122120.0 -13500.0 -0.51 -0.2236 -0.4132 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 O24 mock treatment 108560.0 -3970.0 -0.15 136440.0 821.0 0.03 -0.0872 -0.5547 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P01 compound treatment 96600.0 -15900.0 -0.62 124040.0 -11600.0 -0.43 -0.7444 -0.9851 1004729 TimTec1_000331 COC(=O)c1ccccc1C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P02 compound treatment 75080.0 -37500.0 -1.45 78600.0 -57000.0 -2.14 -2.5408 -0.9822 3210133 TimTec1_000332 O=C(Oc1cc(OC(=O)c2ccco2)cc(OC(=O)c3ccco3)c1)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P03 compound treatment 78160.0 -34400.0 -1.33 106280.0 -29300.0 -1.1 -1.7217 -0.9955 3081813 TimTec1_000333 CCOC(=O)Cc1c(SC)c2ccccc2n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P04 compound treatment 99920.0 -12600.0 -0.49 109880.0 -25700.0 -0.97 -1.0291 -0.9503 3081814 TimTec1_000334 CCN(CC)CCOc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P05 compound treatment 103760.0 -8770.0 -0.34 109320.0 -26300.0 -0.99 -0.9387 -0.899 3210134 TimTec1_000335 O=C(Cc1ccccc1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P06 compound treatment 76920.0 -35600.0 -1.38 66560.0 -69100.0 -2.59 -2.8098 -0.9566 1158366 TimTec1_000336 O=C(Nc1ccccc1)C(=S)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P07 compound treatment 57280.0 -55300.0 -2.14 39040.0 -96600.0 -3.62 -4.079 -0.9686 1365315 TimTec1_000337 CCOC(=O)c1c(COC(=O)C)n(C)c2cc(Br)c(OC)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P08 compound treatment 119200.0 6670.0 0.26 68320.0 -67300.0 -2.53 -1.6031 -0.6314 1268733 TimTec1_000338 Nc1c(N2CCN(CC2)c3ccccc3)c4ccccc4oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P09 compound treatment 95440.0 -17100.0 -0.66 91520.0 -44100.0 -1.66 -1.6393 -0.9194 1047274 TimTec1_000339 CC(=O)Nc1ccc(OCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P10 compound treatment 79360.0 -33200.0 -1.29 62160.0 -73500.0 -2.76 -2.8597 -0.9398 1459196 TimTec1_000340 CCSc1nnc-2c(OC3(Nc4ccccc42)C(=O)Nc5ccc(Br)cc53)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P11 compound treatment 97400.0 -15100.0 -0.59 82440.0 -53200.0 -2.0 -1.8265 -0.8779 1347458 TimTec1_000341 CCOC(=O)c1oc2ccccc2c1NC(=O)CCN3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P12 compound treatment 67840.0 -44700.0 -1.73 54080.0 -81500.0 -3.06 -3.3902 -0.9638 1693186 TimTec1_000342 Cc1nn2c(=O)c3CCCc3[nH]c2c1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P13 compound treatment 92040.0 -20500.0 -0.8 97920.0 -37700.0 -1.41 -1.5627 -0.9629 1228757 TimTec1_000343 CC1(C)CC(=O)c2c(c([nH]c2C1)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P14 compound treatment 123040.0 10500.0 0.41 118120.0 -17500.0 -0.66 -0.1761 -0.2279 3081883 TimTec1_000344 NCCCc1nc2cc3sc(CCCN)nc3cc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P15 compound treatment 73000.0 -39500.0 -1.53 76480.0 -59100.0 -2.22 -2.6541 -0.9837 1650512 TimTec1_000345 CC1=NN(C(=O)Cc2ccccc2)C(O)(C1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P16 compound treatment 99880.0 -12700.0 -0.49 97000.0 -38600.0 -1.45 -1.3721 -0.8966 3081885 TimTec1_000346 N#Cc1ccc(C#N)c(c1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P17 compound treatment 87320.0 -25200.0 -0.98 71280.0 -64300.0 -2.41 -2.3992 -0.9209 3081886 TimTec1_000347 Cc1ccc(cc1)C2=C/C(=C/3\OC(=O)c4ccccc34)/C(=O)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P18 compound treatment 78200.0 -34300.0 -1.33 55320.0 -80300.0 -3.01 -3.073 -0.9326 3210253 TimTec1_000348 COC(=O)NC(Nc1ccccc1C(F)(F)F)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P19 compound treatment 84480.0 -28100.0 -1.09 69040.0 -66600.0 -2.5 -2.5366 -0.9307 1111738 TimTec1_000349 Cc1nc(NC(=N)N)nc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P20 compound treatment 110800.0 -1730.0 -0.07 104520.0 -31100.0 -1.17 -0.8729 -0.7466 1449841 TimTec1_000350 OC(=O)CCN1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P21 compound treatment 95560.0 -17000.0 -0.66 102760.0 -32900.0 -1.23 -1.3377 -0.9568 1530469 TimTec1_000351 O=C(CSc1nc2ccccc2s1)NC3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P22 compound treatment 90000.0 -22500.0 -0.87 111800.0 -23800.0 -0.89 -1.2504 -0.9999 1494539 TimTec1_000352 CCCN(CCC)C(=O)c1cnn(c1NC(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P23 mock treatment 99680.0 -12900.0 -0.5 132800.0 -2820.0 -0.11 -0.4275 -0.8384 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2063 P24 mock treatment 94080.0 -18500.0 -0.72 125840.0 -9780.0 -0.37 -0.7658 -0.9518 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A01 compound treatment 103360.0 -9590.0 -0.37 144960.0 21400.0 0.8 0.3044 0.344 3081276 TimTec1_000705 CN(C)C(=O)c1cc(Cl)ccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A02 compound treatment 64960.0 -48000.0 -1.86 101440.0 -22100.0 -0.83 -1.9041 -0.9338 1727664 TimTec1_000706 Cc1cccc(NC(=O)c2cnn(c2NC(=O)c3ccco3)c4ccccc4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A03 compound treatment 33440.0 -79500.0 -3.09 173120.0 49500.0 1.86 -0.8666 -0.2406 1225534 TimTec1_000707 O=C(CC(c1ccccc1)c2ccccc2)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A04 compound treatment 11640.0 -101000.0 -3.93 77200.0 -46400.0 -1.74 -4.0103 -0.9328 3211034 TimTec1_000708 COC(=O)CSc1nc(ccc1C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A05 compound treatment 198440.0 85500.0 3.32 215480.0 91900.0 3.45 4.7845 0.9998 1669652 TimTec1_000709 O=C(CSc1nc2ccccc2o1)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A06 compound treatment 177480.0 64500.0 2.5 192600.0 69000.0 2.59 3.6022 0.9999 1013954 TimTec1_000710 COC(=O)c1cccc(c1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A07 compound treatment 156360.0 43400.0 1.68 190720.0 67100.0 2.52 2.9729 0.9808 1089954 TimTec1_000711 OC(=O)c1ccc(Oc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A08 compound treatment 117480.0 4530.0 0.18 170960.0 47400.0 1.78 1.3818 0.7732 1005718 TimTec1_000712 OC(=O)CCC(=O)OCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A09 compound treatment 6880.0 -106000.0 -4.12 9040.0 -115000.0 -4.3 -5.9498 -0.9998 1474924 TimTec1_000713 CN(C)Cc1ccc(cc1)C(=O)Oc2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A10 compound treatment 5760.0 -107000.0 -4.16 7080.0 -116000.0 -4.37 -6.0326 -0.9997 3211035 TimTec1_000714 Oc1cccc(/N=C/c2cc(Br)ccc2O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A11 compound treatment 94360.0 -18600.0 -0.72 94200.0 -29400.0 -1.1 -1.2897 -0.9789 3081282 TimTec1_000715 Cc1ccc(O)c(c1)C2=Nc3ccccc3N=C(C2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A12 compound treatment 126240.0 13300.0 0.52 134320.0 10700.0 0.4 0.6497 0.9926 1433969 TimTec1_000716 Cc1cccc(c1)C(=O)NN(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A13 compound treatment 182520.0 69600.0 2.7 189080.0 65500.0 2.46 3.6471 0.9989 1483255 TimTec1_000717 CC(=O)Nc1cccc2ncccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A14 compound treatment 84680.0 -28300.0 -1.1 79080.0 -44500.0 -1.67 -1.9565 -0.9792 1158197 TimTec1_000718 COc1ccc(cc1)C(=O)Nc2ccc(C)c(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A15 compound treatment 170400.0 57400.0 2.23 174400.0 50800.0 1.91 2.925 0.997 3211036 TimTec1_000719 C/C(=N\n1cnnc1)/CC(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A16 compound treatment 113680.0 727.0 0.03 109080.0 -14500.0 -0.54 -0.3647 -0.6695 1075886 TimTec1_000720 FC(F)(F)c1cccc(NS(=O)(=O)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A17 compound treatment 179320.0 66400.0 2.58 183200.0 59600.0 2.24 3.4032 0.9976 1922764 TimTec1_000721 OC(=O)c1cc(/N=C/c2ccccc2O)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A18 compound treatment 87960.0 -25000.0 -0.97 63200.0 -60400.0 -2.27 -2.288 -0.9283 1340286 TimTec1_000722 COc1ccc(cc1)S(=O)(=O)Nc2cc(C)cc(C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A19 compound treatment 7680.0 -105000.0 -4.08 7080.0 -116000.0 -4.37 -5.9799 -0.9994 1715796 TimTec1_000723 CCOC(=O)c1c(CSc2nc(C)ccc2C#N)oc3ccc(OC(=O)C)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A20 compound treatment 150360.0 37400.0 1.45 141240.0 17700.0 0.66 1.4951 0.937 3211037 TimTec1_000724 COC(=O)C1=C(N)C(=c2s/c(=C/c3ccccc3)/c(=O)n2C1c4ccccc4)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A21 compound treatment 8600.0 -104000.0 -4.05 8480.0 -115000.0 -4.32 -5.9175 -0.9995 3081301 TimTec1_000725 NC1=C(C#N)[C@@H]([C@H](S1)C(=O)c2ccccc2)c3ccc(Br)c(F)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A22 compound treatment 180840.0 67900.0 2.63 183400.0 59800.0 2.25 3.4503 0.9968 1561863 TimTec1_000726 O=C(Nc1nc(nc2CCCC(=O)c12)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A23 mock treatment 168280.0 55300.0 2.15 164800.0 41200.0 1.55 2.612 0.9871 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 A24 mock treatment 128920.0 16000.0 0.62 126400.0 2830.0 0.11 0.5131 0.8163 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B01 compound treatment 150320.0 37400.0 1.45 171880.0 48300.0 1.81 2.3072 0.9939 3081303 TimTec1_000727 Cc1cccc[n+]1C2[C@H](C(=C(S)N[C@]2(C)O)C#N)c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B02 compound treatment 130800.0 17800.0 0.69 165760.0 42200.0 1.58 1.6092 0.9312 3211038 TimTec1_000728 CC1C(CC(C(=O)O)C1(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B03 compound treatment 122720.0 9770.0 0.38 145080.0 21500.0 0.81 0.8387 0.9406 3211039 TimTec1_000729 CC1=COC=C(/C=N/Cc2ccccc2)N1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B04 compound treatment 7040.0 -106000.0 -4.11 9040.0 -115000.0 -4.3 -5.9454 -0.9997 3081306 TimTec1_000730 O=C(CSC#N)c1cccs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B05 compound treatment 125080.0 12100.0 0.47 162400.0 38800.0 1.46 1.3631 0.8902 1225786 TimTec1_000731 COc1cccc2c1N(C3CC(C)CCC3C2(C)C)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B06 compound treatment 100320.0 -12600.0 -0.49 115240.0 -8330.0 -0.31 -0.5678 -0.9765 1605606 TimTec1_000732 c1ccc(nc1)c2ccc3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B07 compound treatment 145400.0 32400.0 1.26 184040.0 60500.0 2.27 2.4949 0.9614 1478193 TimTec1_000733 CCC(=O)Nc1ncc2C(=O)CC(C)(C)Cc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B08 compound treatment 164400.0 51400.0 2.0 198560.0 75000.0 2.81 3.4015 0.9858 3081309 TimTec1_000734 COc1ccc(cc1)/C(=N/O)/C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B09 compound treatment 163920.0 51000.0 1.98 201000.0 77400.0 2.91 3.4531 0.9824 3211040 TimTec1_000735 CCOC(=O)Cc1n[nH]c(CC(=O)OCC)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B10 compound treatment 61640.0 -51300.0 -1.99 76000.0 -47600.0 -1.79 -2.6704 -0.9985 3081311 TimTec1_000736 Nc1ccc2nn(nc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B11 compound treatment 137880.0 24900.0 0.97 190000.0 66400.0 2.49 2.4468 0.915 1090166 TimTec1_000737 CN(C)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B12 compound treatment 165520.0 52600.0 2.04 176680.0 53100.0 1.99 2.8516 0.9999 3081313 TimTec1_000738 CCOc1ccc(cc1)C(=O)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B13 compound treatment 166560.0 53600.0 2.08 199560.0 76000.0 2.85 3.4873 0.988 3211041 TimTec1_000739 COc1cccc(/C=N/n2cnnc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B14 compound treatment 180880.0 67900.0 2.64 185520.0 61900.0 2.32 3.5076 0.998 3211042 TimTec1_000740 C[N+]1(C/C=C\2/COCO2)CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B15 compound treatment 178200.0 65200.0 2.53 194880.0 71300.0 2.68 3.6825 0.9996 1498488 TimTec1_000741 COc1ccc(CC(=O)NC2CCCCC2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B16 compound treatment 128560.0 15600.0 0.61 120680.0 -2890.0 -0.11 0.3514 0.5712 3211043 TimTec1_000742 OC(=O)c1cc(/C=N/n2cnnc2)c3OCOCc3c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B17 compound treatment 65520.0 -47400.0 -1.84 60280.0 -63300.0 -2.38 -2.9811 -0.992 3211044 TimTec1_000743 Cc1nc(cs1)C2C(Oc3c(O)c(O)ccc3C2=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B18 compound treatment 8920.0 -104000.0 -4.04 8200.0 -115000.0 -4.33 -5.9161 -0.9994 3081317 TimTec1_000744 OC(CN1CC2CC(C1)c3cccc(=O)n3C2)/C=N/n4cnnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B19 compound treatment 178360.0 65400.0 2.54 166000.0 42400.0 1.59 2.9204 0.9748 3081354 TimTec1_000745 C(/C=C\c1ccccc1)N2CCN(Cn3nnc4ccccc34)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B20 compound treatment 198240.0 85300.0 3.31 217760.0 94200.0 3.53 4.8395 0.9995 3081321 TimTec1_000746 CC(CN1CC2CC(C1)c3cccc(=O)n3C2)SC(=N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B21 compound treatment 139800.0 26800.0 1.04 189160.0 65600.0 2.46 2.4772 0.9268 1281576 TimTec1_000747 CN(C1CCCCC1)S(=O)(=O)c2ccc(NC(=O)C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B22 compound treatment 61840.0 -51100.0 -1.98 47640.0 -75900.0 -2.85 -3.4175 -0.9843 1293326 TimTec1_000748 CC1(C)CC(=O)C2=C(C1)Nc3ccc4ccccc4c3C2c5cccnc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B23 mock treatment 193360.0 80400.0 3.12 204720.0 81100.0 3.05 4.3596 0.9999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 B24 mock treatment 159320.0 46400.0 1.8 165000.0 41400.0 1.55 2.3715 0.9974 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C01 compound treatment 110400.0 -2550.0 -0.1 167360.0 43800.0 1.64 1.092 0.6633 3081323 TimTec1_000749 CC1CCN(CC1)C(=O)c2cc(Cl)ccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C02 compound treatment 114040.0 1090.0 0.04 171280.0 47700.0 1.79 1.2959 0.7236 1165155 TimTec1_000750 CCN(CC)C(=O)c1cnn(c1NC(=O)c2ccco2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C03 compound treatment 8040.0 -105000.0 -4.07 9720.0 -114000.0 -4.27 -5.9 -0.9997 3081325 TimTec1_000751 CCN(CC)c1ccc(/C=N/O)c(O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C04 compound treatment 109080.0 -3870.0 -0.15 183800.0 60200.0 2.26 1.4921 0.6586 1058529 TimTec1_000752 OC(=O)c1ccccc1N2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C05 compound treatment 120920.0 7970.0 0.31 131280.0 7710.0 0.29 0.4231 0.9994 1643767 TimTec1_000753 CSc1nc2ccccc2n1CC(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C06 compound treatment 135840.0 22900.0 0.89 177800.0 54200.0 2.04 2.067 0.9309 1016928 TimTec1_000754 CC(C)CNC(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C07 compound treatment 113760.0 807.0 0.03 129760.0 6190.0 0.23 0.1863 0.7953 3211045 TimTec1_000755 Cc1ccc(C)n1c2ccc(cc2)C(=O)OCC(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C08 compound treatment 127320.0 14400.0 0.56 135720.0 12100.0 0.46 0.7165 0.995 1586419 TimTec1_000756 CC1CC2OC(C)(C)OC2C(OC(=O)c3ccccc3)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C09 compound treatment 105280.0 -7670.0 -0.3 142120.0 18500.0 0.7 0.2817 0.3721 1233022 TimTec1_000757 CC(C)CCOc1ccccc1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C10 compound treatment 11520.0 -101000.0 -3.94 68000.0 -55600.0 -2.09 -4.2578 -0.9559 3081330 TimTec1_000758 Cc1ccc(/N=C/c2cc3ccccc3nc2Cl)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C11 compound treatment 16080.0 -96900.0 -3.76 40960.0 -82600.0 -3.1 -4.8503 -0.9954 3211046 TimTec1_000759 FC(F)(F)c1cc(no1)c2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C12 compound treatment 129200.0 16200.0 0.63 172080.0 48500.0 1.82 1.733 0.8996 3081332 TimTec1_000760 Cc1cccc(c1)C(=O)N(CC#N)CC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C13 compound treatment 136440.0 23500.0 0.91 144240.0 20700.0 0.78 1.1928 0.9968 3211047 TimTec1_000761 O=C(NN1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C14 compound treatment 129200.0 16200.0 0.63 165080.0 41500.0 1.56 1.5473 0.9207 1022870 TimTec1_000762 O=C(NCc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C15 compound treatment 86200.0 -26800.0 -1.04 103720.0 -19900.0 -0.75 -1.2609 -0.9868 3211048 TimTec1_000763 C(=N/c1cccnc1)\c2c[nH]c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C16 compound treatment 130560.0 17600.0 0.68 154640.0 31100.0 1.17 1.3075 0.9676 1045873 TimTec1_000764 O=S(=O)(NCCc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C17 compound treatment 133320.0 20400.0 0.79 150840.0 27300.0 1.02 1.2824 0.9918 3211049 TimTec1_000765 Cc1c(/N=C/c2cccc(C)c2)c(=O)n(c3ccccc3)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C18 compound treatment 121120.0 8170.0 0.32 117600.0 -5970.0 -0.22 0.0655 0.1688 1634239 TimTec1_000766 O=C(CCCC(=O)Nc1cccc2ccccc12)Nc3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C19 compound treatment 8000.0 -105000.0 -4.07 8080.0 -115000.0 -4.33 -5.9446 -0.9995 3081336 TimTec1_000767 O=C(CSc1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C20 compound treatment 131040.0 18100.0 0.7 136400.0 12800.0 0.48 0.8366 0.9831 1173423 TimTec1_000768 CCOC(=O)C1=C(C(=O)c2ccccc2)C3(C(=O)Nc4ccccc43)C(=C(N)O1)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C21 compound treatment 138200.0 25200.0 0.98 142680.0 19100.0 0.72 1.1997 0.9882 1130405 TimTec1_000769 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C32CCN(Cc4ccccc4)CC3)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C22 compound treatment 128520.0 15600.0 0.6 128840.0 5270.0 0.2 0.5668 0.8919 3211050 TimTec1_000770 Cc1cc(c2c(n1)sc3c(=O)[nH]c(C)nc32)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C23 mock treatment 175280.0 62300.0 2.42 162360.0 38800.0 1.46 2.7393 0.9705 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 C24 mock treatment 149560.0 36600.0 1.42 135200.0 11600.0 0.44 1.3129 0.8836 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D01 compound treatment 121640.0 8690.0 0.34 154240.0 30700.0 1.15 1.0522 0.8773 1332544 TimTec1_000771 CCCN1CCC2(CC1)C(C#N)C(=O)NC(=C2C#N)S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D02 compound treatment 60280.0 -52700.0 -2.04 56920.0 -66700.0 -2.5 -3.2141 -0.995 1267101 TimTec1_000772 CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN4CCOCC4)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D03 compound treatment 119240.0 6290.0 0.24 129960.0 6390.0 0.24 0.342 1.0 3211051 TimTec1_000773 C(/N=C/C1=CSC=CN1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D04 compound treatment 144120.0 31200.0 1.21 153400.0 29800.0 1.12 1.6466 0.9993 1527522 TimTec1_000774 S=c1n(CN2CCCCC2)nc(c3ccccc3)n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D05 compound treatment 37440.0 -75500.0 -2.93 41800.0 -81800.0 -3.07 -4.242 -0.9997 1323715 TimTec1_000775 CC1C=C(C)C2C(C)C1COC2c3ccc(OC(=O)NC4CCCCC4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D06 compound treatment 8960.0 -104000.0 -4.03 10000.0 -114000.0 -4.26 -5.8673 -0.9996 1445377 TimTec1_000776 CC12CCC(C(=O)CO)C2(C)CCC3(C)C4(C)CCC(=O)C=C4CCC13C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D07 compound treatment 93960.0 -19000.0 -0.74 103680.0 -19900.0 -0.75 -1.0491 -1.0 3209076 TimTec1_000777 FC(F)(F)c1cc(nc2cc(nn12)C(=O)N(Cc3ccccc3)Cc4ccccc4)c5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D08 compound treatment 125080.0 12100.0 0.47 128120.0 4550.0 0.17 0.4534 0.9058 1519326 TimTec1_000778 CCOC(=O)C1=C(CC2=C1CCCC2)NC(=S)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D09 compound treatment 96640.0 -16300.0 -0.63 82920.0 -40700.0 -1.53 -1.5265 -0.9241 1679838 TimTec1_000779 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D10 compound treatment 129320.0 16400.0 0.64 127160.0 3590.0 0.13 0.5442 0.8383 1574797 TimTec1_000780 CCCC(=O)Nc1ccc(N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D11 compound treatment 31920.0 -81000.0 -3.14 31640.0 -91900.0 -3.45 -4.663 -0.9989 3209077 TimTec1_000781 CCOC(=O)c1c(NC(=O)OC)sc2CCCCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D12 compound treatment 9280.0 -104000.0 -4.02 9760.0 -114000.0 -4.27 -5.8649 -0.9995 1560316 TimTec1_000782 CCOC(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D13 compound treatment 11400.0 -102000.0 -3.94 11280.0 -112000.0 -4.21 -5.7664 -0.9994 3081341 TimTec1_000783 Nc1nc(nc(n1)C(F)(F)F)N(Cc2ccccc2)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D14 compound treatment 131680.0 18700.0 0.73 138960.0 15400.0 0.58 0.9221 0.9935 3209078 TimTec1_000784 Cc1ccoc1CC[N+](C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D15 compound treatment 120040.0 7090.0 0.27 111960.0 -11600.0 -0.44 -0.1138 -0.2208 1672714 TimTec1_000785 COc1ccccc1CC(=O)N(CC=C)CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D16 compound treatment 144960.0 32000.0 1.24 152920.0 29300.0 1.1 1.657 0.9982 3209079 TimTec1_000786 C1COc2cccc(/C=N\n3cnnc3)c2OC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D17 compound treatment 88880.0 -24100.0 -0.93 85600.0 -38000.0 -1.43 -1.6683 -0.979 3209080 TimTec1_000787 CCC(O)c1ccc2c(=O)c(coc2c1)c3ccccc3F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D18 compound treatment 8880.0 -104000.0 -4.04 8680.0 -115000.0 -4.31 -5.9045 -0.9995 3209081 TimTec1_000788 Cc1c(/N=C/C(O)CN2CC3CC(C2)c4cccc(=O)n4C3)c(=O)n(c5ccccc5)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D19 compound treatment 7240.0 -106000.0 -4.1 6320.0 -117000.0 -4.4 -6.0121 -0.9994 3081342 TimTec1_000789 CC(C)Cc1ccc(/C=C/C(=O)N2CCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D20 compound treatment 15400.0 -97600.0 -3.79 11120.0 -112000.0 -4.22 -5.6609 -0.9985 3081343 TimTec1_000790 CC(=O)N1CCCCC1c2cccnc2.[O-][N+](=O)O[Ag] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D21 compound treatment 130360.0 17400.0 0.68 138160.0 14600.0 0.55 0.8647 0.9946 1588159 TimTec1_000791 CS(=O)(=O)Nc1ccc2CCc3cccc1c32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D22 compound treatment 132680.0 19700.0 0.77 133520.0 9950.0 0.37 0.8052 0.9455 1287290 TimTec1_000792 COC(=O)c1c(C)nc(C)c2c(=O)oc3ccccc3c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D23 mock treatment 143280.0 30300.0 1.18 138960.0 15400.0 0.58 1.2404 0.9463 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 D24 mock treatment 125600.0 12600.0 0.49 126960.0 3390.0 0.13 0.4368 0.8618 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E01 compound treatment 12320.0 -101000.0 -3.9 14240.0 -109000.0 -4.1 -5.6626 -0.9997 1535367 TimTec1_000793 CCC(C)c1ccc(NC(=O)c2ccc(cc2)N(CC)CC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E02 compound treatment 97640.0 -15300.0 -0.59 108600.0 -15000.0 -0.56 -0.8175 -0.9996 1215550 TimTec1_000794 CC(C)(C)C(=O)Nc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E03 compound treatment 42240.0 -70700.0 -2.74 69400.0 -54200.0 -2.03 -3.3778 -0.9891 1689344 TimTec1_000795 Clc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)Cc3ccccc3)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E04 compound treatment 119400.0 6450.0 0.25 143680.0 20100.0 0.75 0.7105 0.8937 3209082 TimTec1_000796 O(c1ccccc1)c2ccc(/C=N/c3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E05 compound treatment 31320.0 -81600.0 -3.17 35240.0 -88300.0 -3.32 -4.584 -0.9997 3081345 TimTec1_000797 NC(CSCc1oc(cc1C(=O)O)c2ccccc2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E06 compound treatment 42560.0 -70400.0 -2.73 48800.0 -74800.0 -2.81 -3.9157 -0.9999 1921518 TimTec1_000798 COc1ccc(NC(=O)/C=C/c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E07 compound treatment 126360.0 13400.0 0.52 137560.0 14000.0 0.52 0.739 1.0 1601233 TimTec1_000799 OC(=O)C1C(C2CCC1C2)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E08 compound treatment 99960.0 -13000.0 -0.5 124360.0 786.0 0.03 -0.3356 -0.6646 3081347 TimTec1_000800 CCOC1(C)OC2CCC(CC)OC2O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E09 compound treatment 30680.0 -82300.0 -3.19 40960.0 -82600.0 -3.1 -4.4497 -0.9999 3082473 TimTec1_000801 CCc1ccc(cc1)C(=O)CSc2nnc(c3cccc(OC)c3)n2CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E10 compound treatment 74960.0 -38000.0 -1.47 91840.0 -31700.0 -1.19 -1.8846 -0.9944 3082474 TimTec1_000802 COc1cc(/N=C/c2cc3cccc(C)c3nc2Cl)c(OC)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E11 compound treatment 18840.0 -94100.0 -3.65 23120.0 -100000.0 -3.77 -5.248 -0.9999 3209083 TimTec1_000803 CCCC[n+]1cc(nc(n1)N2CCCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E12 compound treatment 114280.0 1330.0 0.05 118680.0 -4890.0 -0.18 -0.0935 -0.49 3209084 TimTec1_000804 O=C(Cc1ccccc1)NC2CCCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E13 compound treatment 105640.0 -7310.0 -0.28 106040.0 -17500.0 -0.66 -0.666 -0.9293 1914322 TimTec1_000805 Clc1ccc(/N=C/c2c[nH]c3ccccc23)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E14 compound treatment 127760.0 14800.0 0.57 136320.0 12700.0 0.48 0.7445 0.9959 1916639 TimTec1_000806 O=C(c1ccccc1)n2cnc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E15 compound treatment 99680.0 -13300.0 -0.51 105600.0 -18000.0 -0.67 -0.8412 -0.9911 1607222 TimTec1_000807 COc1ccc(cc1)C2(Cc3nc4ccccc4[nH]3)C(=O)c5ccccc5C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E16 compound treatment 122920.0 9970.0 0.39 119440.0 -4130.0 -0.16 0.1637 0.393 1418431 TimTec1_000808 O=S(=O)(NC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E17 compound treatment 86120.0 -26800.0 -1.04 81040.0 -42500.0 -1.6 -1.865 -0.9785 3082475 TimTec1_000809 Fc1ccc(/C=N/c2ccc(I)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E18 compound treatment 117720.0 4770.0 0.18 128680.0 5110.0 0.19 0.2663 0.9998 1450437 TimTec1_000810 COC(=O)c1cc(NS(=O)(=O)c2ccccc2)cc(c1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E19 compound treatment 74160.0 -38800.0 -1.51 60920.0 -62700.0 -2.35 -2.7271 -0.9768 1573675 TimTec1_000811 O=C(C1c2ccccc2Oc3ccccc13)N4CCCc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E20 compound treatment 86240.0 -26700.0 -1.04 68120.0 -55500.0 -2.08 -2.2046 -0.9482 1156098 TimTec1_000812 NC1=C(C(=O)OCc2ccccc2)C3(C(=O)Nc4ccc(Br)cc43)C5=C(O1)C(=O)CCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E21 compound treatment 8320.0 -105000.0 -4.06 6920.0 -117000.0 -4.38 -5.9666 -0.9993 1774639 TimTec1_000813 [O-][n+]1onc2c3cc([nH]c3ccc12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E22 compound treatment 8760.0 -104000.0 -4.04 8760.0 -115000.0 -4.31 -5.9057 -0.9995 1601319 TimTec1_000814 CCOc1ccc(cc1)C2(C)CC(C)(C)Nc3ccccc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E23 mock treatment 130360.0 17400.0 0.68 122600.0 -974.0 -0.04 0.4517 0.6678 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 E24 mock treatment 109320.0 -3630.0 -0.14 124760.0 1190.0 0.04 -0.0682 -0.4614 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F01 compound treatment 34240.0 -78700.0 -3.05 35920.0 -87700.0 -3.29 -4.4858 -0.9993 3209085 TimTec1_000815 Oc1n[nH]c(c1C(C(C#N)C#N)c2ccsc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F02 compound treatment 122040.0 9090.0 0.35 126080.0 2510.0 0.09 0.3158 0.8655 1492048 TimTec1_000816 C(C1NCC=N1)c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F03 compound treatment 8040.0 -105000.0 -4.07 9240.0 -114000.0 -4.29 -5.9127 -0.9997 3209086 TimTec1_000817 O=c/1[nH]c2ccccc2[nH]\c1=N/C(=S)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F04 compound treatment 137920.0 25000.0 0.97 149720.0 26100.0 0.98 1.3789 1.0 1173360 TimTec1_000818 COc1ccc(cc1OC)C(=O)NC(CO)(CO)CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F05 compound treatment 138320.0 25400.0 0.98 145440.0 21900.0 0.82 1.2763 0.9959 1399424 TimTec1_000819 C1C2C(Oc3ccccc3C2Oc4ccccc14)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F06 compound treatment 128880.0 15900.0 0.62 133720.0 10100.0 0.38 0.7062 0.9729 1110045 TimTec1_000820 CN(C1CCCCC1)S(=O)(=O)c2ccc(N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F07 compound treatment 134520.0 21600.0 0.84 142400.0 18800.0 0.71 1.0913 0.9965 3209087 TimTec1_000821 CC(C)C1=C2CCCCC2NC(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F08 compound treatment 130160.0 17200.0 0.67 142480.0 18900.0 0.71 0.9738 0.9995 1005088 TimTec1_000822 COC(=O)c1cc(C(=O)OC)c(cc1C(=O)OC)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F09 compound treatment 76880.0 -36100.0 -1.4 76360.0 -47200.0 -1.77 -2.2427 -0.9932 1428753 TimTec1_000823 CC(=O)Nc1ccc(cc1)S(=O)(=O)n2cnc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F10 compound treatment 129320.0 16400.0 0.64 135320.0 11700.0 0.44 0.7608 0.9841 1121309 TimTec1_000824 CCCC(=O)Nc1cccc(N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F11 compound treatment 9120.0 -104000.0 -4.03 9200.0 -114000.0 -4.29 -5.8841 -0.9995 1703558 TimTec1_000825 NC1=C(C#N)C2=CCCCC2C3(C(=O)N(Cc4ccccc4)c5ccccc53)C1(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F12 compound treatment 136000.0 23000.0 0.89 134760.0 11200.0 0.42 0.9292 0.9406 1304433 TimTec1_000826 CN(C)CC#CC1(O)CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F13 compound treatment 136360.0 23400.0 0.91 121240.0 -2330.0 -0.09 0.5802 0.6359 3209088 TimTec1_000827 CN(C)c1ccc(/C=C/2\CSC(=S)NC2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F14 compound treatment 132400.0 19400.0 0.75 136960.0 13400.0 0.5 0.8888 0.9805 3082476 TimTec1_000828 CC/1(OCO\C1=C/C[N+](C)(C)C)C=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F15 compound treatment 128240.0 15300.0 0.59 127200.0 3630.0 0.14 0.5156 0.8473 3209089 TimTec1_000829 COc1ccccc1CC(=O)N2CCCC(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F16 compound treatment 128120.0 15200.0 0.59 134320.0 10700.0 0.4 0.7013 0.983 3082477 TimTec1_000830 C(=N/n1cnnc1)\c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F17 compound treatment 97160.0 -15800.0 -0.61 91000.0 -32600.0 -1.22 -1.2978 -0.949 1177709 TimTec1_000831 CCc1cc(c2n[nH]cc2c3nc(C)cs3)c(O)cc1OC(C)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F18 compound treatment 133440.0 20500.0 0.79 137560.0 14000.0 0.52 0.9333 0.9797 3082478 TimTec1_000832 Cc1c(/N=C\C2CCCN3CCCCC23)c(=O)n(c4ccccc4)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F19 compound treatment 131240.0 18300.0 0.71 127360.0 3790.0 0.14 0.6022 0.8322 3209090 TimTec1_000833 COc1cc(Br)cc(CNc2cc(C)on2)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F20 compound treatment 144720.0 31800.0 1.23 141040.0 17500.0 0.66 1.3351 0.9563 3209091 TimTec1_000834 O=C(/C=C/c1ccccc1)N2CCCCC2c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F21 compound treatment 50480.0 -62500.0 -2.42 48080.0 -75500.0 -2.83 -3.7175 -0.997 3082479 TimTec1_000835 COc1ccc(NC(=S)SC)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F22 compound treatment 128720.0 15800.0 0.61 118400.0 -5170.0 -0.19 0.2953 0.46 1375719 TimTec1_000836 CCCC1=C(C(NC(=O)N1)c2cc(Br)c(O)c(OC)c2)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F23 mock treatment 134760.0 21800.0 0.85 127520.0 3950.0 0.15 0.703 0.8184 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 F24 mock treatment 102280.0 -10700.0 -0.41 113760.0 -9810.0 -0.37 -0.5533 -0.9983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G01 compound treatment 84680.0 -28300.0 -1.1 105120.0 -18500.0 -0.69 -1.2654 -0.9754 1641121 TimTec1_000837 CCC(C)NC(=O)c1ccc(cc1)N(CC)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G02 compound treatment 49080.0 -63900.0 -2.48 99880.0 -23700.0 -0.89 -2.3812 -0.9044 1504788 TimTec1_000838 Clc1cccc(c1)c2nc3n(ncc3c(=O)o2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G03 compound treatment 106080.0 -6870.0 -0.27 140920.0 17300.0 0.65 0.2718 0.3863 1392995 TimTec1_000839 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G04 compound treatment 115760.0 2810.0 0.11 134960.0 11400.0 0.43 0.3792 0.8598 1261047 TimTec1_000840 O=C1NC(C(N1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G05 compound treatment 109320.0 -3630.0 -0.14 119400.0 -4170.0 -0.16 -0.2104 -0.9986 3082481 TimTec1_000841 Sc1nccn1CCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G06 compound treatment 105920.0 -7030.0 -0.27 123600.0 25.8 0.0 -0.1923 -0.7046 1044409 TimTec1_000842 O=C(Nc1ccccc1)C(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G07 compound treatment 111280.0 -1670.0 -0.06 120840.0 -2730.0 -0.1 -0.1185 -0.9756 1679314 TimTec1_000843 NC(=O)C1C(C2CCC1C2)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G08 compound treatment 9960.0 -103000.0 -4.0 10240.0 -113000.0 -4.25 -5.8335 -0.9995 3082485 TimTec1_000844 Clc1ccc(/N=C/c2ccc(Br)o2)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G09 compound treatment 87520.0 -25400.0 -0.99 94760.0 -28800.0 -1.08 -1.4625 -0.999 1181154 TimTec1_000845 O=c1n(c(SCc2ccc3OCOc3c2)nc4ccccc14)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G10 compound treatment 86200.0 -26800.0 -1.04 92920.0 -30700.0 -1.15 -1.5475 -0.9987 3082487 TimTec1_000846 Cc1ccc(/N=C/c2cc3ccccc3nc2Cl)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G11 compound treatment 11640.0 -101000.0 -3.93 11800.0 -112000.0 -4.2 -5.746 -0.9995 1384410 TimTec1_000847 CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(nc(nn12)N3CCOCC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G12 compound treatment 119760.0 6810.0 0.26 122160.0 -1410.0 -0.05 0.1492 0.5539 1271027 TimTec1_000848 COc1ccc(CC(=O)NCC(C)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G13 compound treatment 112000.0 -953.0 -0.04 119600.0 -3970.0 -0.15 -0.1316 -0.8565 3209212 TimTec1_000849 Cc1ccc(/N=C/c2c[nH]c3ccccc23)nc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G14 compound treatment 103320.0 -9630.0 -0.37 106960.0 -16600.0 -0.62 -0.7052 -0.97 1290233 TimTec1_000850 Brc1ccc(cc1)S(=O)(=O)N2CCCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G15 compound treatment 118840.0 5890.0 0.23 117160.0 -6410.0 -0.24 -0.0087 -0.0262 3209213 TimTec1_000851 CCCNc1nc(Cl)nc(NCCC)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G16 compound treatment 88440.0 -24500.0 -0.95 55800.0 -67800.0 -2.54 -2.4712 -0.91 1275135 TimTec1_000852 O=S(=O)(N(c1ccccc1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G17 compound treatment 52040.0 -60900.0 -2.36 51560.0 -72000.0 -2.7 -3.5824 -0.9978 3209214 TimTec1_000853 NS(=O)(=O)c1ccc(/N=C/c2c(O)ccc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G18 compound treatment 95720.0 -17200.0 -0.67 94200.0 -29400.0 -1.1 -1.2524 -0.9713 3082492 TimTec1_000854 COc1ccc(OC)c(NS(=O)(=O)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G19 compound treatment 63920.0 -49000.0 -1.9 100080.0 -23500.0 -0.88 -1.9688 -0.9389 3209215 TimTec1_000855 Cc1cc(nn1CC(=O)Nc2sc(C)c(C)c2C(=O)N)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G20 compound treatment 130000.0 17000.0 0.66 137600.0 14000.0 0.53 0.8399 0.9936 1545537 TimTec1_000856 Cc1cc(C)c2oc(nc2c1)c3ccc(NC(=O)COc4ccc(Br)cc4)cc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G21 compound treatment 136160.0 23200.0 0.9 135800.0 12200.0 0.46 0.9612 0.9511 1150900 TimTec1_000857 On1c(nc-2c1CCc3nonc32)c4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G22 compound treatment 102760.0 -10200.0 -0.4 91760.0 -31800.0 -1.19 -1.124 -0.8936 3082530 TimTec1_000858 Cc1cc(C)c(C#N)c(SCc2cc(O)[nH]n2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G23 mock treatment 124240.0 11300.0 0.44 131120.0 7550.0 0.28 0.5099 0.9777 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 G24 mock treatment 103240.0 -9710.0 -0.38 103360.0 -20200.0 -0.76 -0.8029 -0.9479 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H01 compound treatment 104680.0 -8270.0 -0.32 106560.0 -17000.0 -0.64 -0.6785 -0.9494 1198410 TimTec1_000859 Cc1[nH]nc(O)c1C2(C(C#N)C#N)C3CC4CC(C3)CC2C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H02 compound treatment 105280.0 -7670.0 -0.3 116520.0 -7050.0 -0.26 -0.3977 -0.9983 3209216 TimTec1_000860 Cc1ccc(OCc2nnc(S)n2c3ccccc3)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H03 compound treatment 102800.0 -10200.0 -0.39 105240.0 -18300.0 -0.69 -0.7651 -0.965 1739416 TimTec1_000861 CCN(CC)c1[nH]nnc1c2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H04 compound treatment 125080.0 12100.0 0.47 127360.0 3790.0 0.14 0.4332 0.8813 3082533 TimTec1_000862 CCOC(=O)c1ccc(SC)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H05 compound treatment 105440.0 -7510.0 -0.29 104160.0 -19400.0 -0.73 -0.7214 -0.9192 1302286 TimTec1_000863 O=C(C1CC2CCC1C2)N3CCN(CC3)c4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H06 compound treatment 127400.0 14400.0 0.56 139600.0 16000.0 0.6 0.8217 0.9994 1696584 TimTec1_000864 COc1ccc(cc1)C2OC(=O)c3ccccc3S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H07 compound treatment 70960.0 -42000.0 -1.63 83800.0 -39800.0 -1.49 -2.2077 -0.999 1246999 TimTec1_000865 CC1C=C(C)C2C(C)C1(COC(=O)NC3CCCCC3)COC42CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H08 compound treatment 112520.0 -433.0 -0.02 114960.0 -8610.0 -0.32 -0.2405 -0.7428 3209217 TimTec1_000866 Sc1nnc(COc2ccccc2)n1CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H09 compound treatment 85240.0 -27700.0 -1.08 79480.0 -44100.0 -1.65 -1.9305 -0.9782 1579810 TimTec1_000867 Clc1ccc(cc1)C(=O)N2CCCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H10 compound treatment 123360.0 10400.0 0.4 133960.0 10400.0 0.39 0.5612 0.9998 1114790 TimTec1_000868 Cc1ccc(OCC(=O)O)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H11 compound treatment 59080.0 -53900.0 -2.09 56120.0 -67500.0 -2.53 -3.2682 -0.9955 1201078 TimTec1_000869 COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H12 compound treatment 124240.0 11300.0 0.44 136800.0 13200.0 0.5 0.6607 0.998 1549339 TimTec1_000870 CC(O)(C#CCN1CCOCC1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H13 compound treatment 90600.0 -22400.0 -0.87 80640.0 -42900.0 -1.61 -1.7527 -0.9578 3209218 TimTec1_000871 Clc1ccccc1/C=C/2\SC3NC(=NN3C2=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H14 compound treatment 138680.0 25700.0 1.0 126040.0 2470.0 0.09 0.7713 0.7694 3082538 TimTec1_000872 CC/1(C)OC(=O)N(\C1=C/C[N+](C)(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H15 compound treatment 114640.0 1690.0 0.07 110200.0 -13400.0 -0.5 -0.3086 -0.6097 1740713 TimTec1_000873 COc1ccccc1CC(=O)Nc2cccc(NC(=O)C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H16 compound treatment 133400.0 20400.0 0.79 133640.0 10100.0 0.38 0.8281 0.9424 1298167 TimTec1_000874 CC(=C1C(=O)NC(=O)NC1=O)c2ccc(N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H17 compound treatment 128440.0 15500.0 0.6 129880.0 6310.0 0.24 0.5923 0.917 3209219 TimTec1_000875 Fc1ccc(cc1)S(=O)(=O)N(C2CCS(=O)(=O)C2)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H18 compound treatment 134480.0 21500.0 0.84 130000.0 6430.0 0.24 0.7612 0.8755 1208196 TimTec1_000876 O=C(N1CC2CC(C1)c3cccc(=O)n3C2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H19 compound treatment 139160.0 26200.0 1.02 132440.0 8870.0 0.33 0.9543 0.892 3082542 TimTec1_000877 CC(=O)NCCOc1c(C)cccc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H20 compound treatment 101160.0 -11800.0 -0.46 97360.0 -26200.0 -0.98 -1.0192 -0.9393 3082544 TimTec1_000878 COc1ccc(OCCSc2nc3ccccc3n2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H21 compound treatment 124040.0 11100.0 0.43 128760.0 5190.0 0.19 0.4418 0.9357 1488809 TimTec1_000879 CC1CCCCN1S(=O)(=O)c2ccc(NC(=O)C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H22 compound treatment 132880.0 19900.0 0.77 129520.0 5950.0 0.22 0.7045 0.8755 1442845 TimTec1_000880 C(Sc1nc(c(o1)c2ccccc2)c3ccccc3)C4COc5ccccc5O4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H23 mock treatment 131880.0 18900.0 0.73 120920.0 -2650.0 -0.1 0.4488 0.6056 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 H24 mock treatment 103160.0 -9790.0 -0.38 105640.0 -17900.0 -0.67 -0.7446 -0.9634 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I01 compound treatment 12520.0 -100000.0 -3.9 48720.0 -74900.0 -2.81 -4.742 -0.9871 1191196 TimTec1_000881 Cc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I02 compound treatment 60240.0 -52700.0 -2.05 111080.0 -12500.0 -0.47 -1.7778 -0.8472 3082580 TimTec1_000882 O=c1oc(nc2sc3CCCCCc3c12)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I03 compound treatment 65040.0 -47900.0 -1.86 110960.0 -12600.0 -0.47 -1.6493 -0.8597 1319708 TimTec1_000883 Cc1cc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCOCC3)no1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I04 compound treatment 103000.0 -9950.0 -0.39 120920.0 -2650.0 -0.1 -0.3435 -0.8613 1427613 TimTec1_000884 Nc1ccc(cc1)C(C2NC(=O)c3ccccc23)c4ccc(N)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I05 compound treatment 66040.0 -46900.0 -1.82 62880.0 -60700.0 -2.28 -2.8979 -0.9938 1467312 TimTec1_000885 Cc1ccccc1NC(=O)CCC(=O)OC2CCC(CC2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I06 compound treatment 108720.0 -4230.0 -0.16 112040.0 -11500.0 -0.43 -0.4222 -0.9119 1018245 TimTec1_000886 CCN(CC)C(=O)C(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I07 compound treatment 97200.0 -15800.0 -0.61 122120.0 -1450.0 -0.05 -0.4708 -0.7672 1540337 TimTec1_000887 O=C(C1C(C#N)C2CCC1C2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I08 compound treatment 81880.0 -31100.0 -1.21 115520.0 -8050.0 -0.3 -1.0663 -0.8578 3082583 TimTec1_000888 OC(=O)c1ccccc1/N=C/c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I09 compound treatment 62480.0 -50500.0 -1.96 90920.0 -32700.0 -1.23 -2.2514 -0.9745 3209220 TimTec1_000889 Cn1c(SCc2ccc3OCOc3c2)nnc1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I10 compound treatment 115360.0 2410.0 0.09 128640.0 5070.0 0.19 0.2005 0.9464 3082586 TimTec1_000890 COC(=O)Nc1ccc(/N=C/c2cccs2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I11 compound treatment 42600.0 -70400.0 -2.73 38760.0 -84800.0 -3.18 -4.1811 -0.9971 3209221 TimTec1_000891 COc1nncc(n1)c2cnnc(SC)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I12 compound treatment 117520.0 4570.0 0.18 123760.0 186.0 0.01 0.1302 0.7344 1639601 TimTec1_000892 COc1ccc(CC(=O)NN2CCN(CC2)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I13 compound treatment 127600.0 14600.0 0.57 128320.0 4750.0 0.18 0.5278 0.8862 3209222 TimTec1_000893 C1CCC(=Nn2cnnc2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I14 compound treatment 102920.0 -10000.0 -0.39 115440.0 -8130.0 -0.31 -0.4911 -0.9928 1554764 TimTec1_000894 CN1CCN(CC1)S(=O)(=O)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I15 compound treatment 89800.0 -23200.0 -0.9 91200.0 -32400.0 -1.22 -1.4944 -0.989 3209223 TimTec1_000895 CCOc1ccc2nc(/N=C/c3ccccc3O)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I16 compound treatment 97320.0 -15600.0 -0.61 98320.0 -25300.0 -0.95 -1.0991 -0.9767 1340130 TimTec1_000896 CC(=O)Nc1cccc(NS(=O)(=O)c2ccc(C)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I17 compound treatment 86560.0 -26400.0 -1.02 94480.0 -29100.0 -1.09 -1.4962 -0.9995 1912630 TimTec1_000897 CCOC(=O)c1ccc(/N=C/c2ccccc2O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I18 compound treatment 118880.0 5930.0 0.23 127080.0 3510.0 0.13 0.2557 0.9649 1423694 TimTec1_000898 COC(=O)c1ccc(C(=O)OC)c(NC(=O)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I19 compound treatment 128480.0 15500.0 0.6 133920.0 10300.0 0.39 0.7006 0.9774 3082591 TimTec1_000899 Nc1c(C#N)sc2nc(ccc12)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I20 compound treatment 134120.0 21200.0 0.82 128120.0 4550.0 0.17 0.7014 0.8361 3209224 TimTec1_000900 CSc1ccc(/N=C/N2C(=O)c3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I21 compound treatment 130800.0 17800.0 0.69 134920.0 11300.0 0.43 0.7908 0.9727 3082593 TimTec1_000901 Oc1[nH]c(=S)[nH]c(=O)c1CN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I22 compound treatment 14360.0 -98600.0 -3.83 14760.0 -109000.0 -4.08 -5.5928 -0.9995 3209346 TimTec1_000902 O=C([C@H]1[C@H](c2cccs2)C(C#N)(C#N)[C@H]3N1C=Cc4ccccc34)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I23 mock treatment 127520.0 14600.0 0.57 123000.0 -574.0 -0.02 0.3844 0.6797 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 I24 mock treatment 100600.0 -12400.0 -0.48 109640.0 -13900.0 -0.52 -0.7087 -0.9991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J01 compound treatment 107000.0 -5950.0 -0.23 110160.0 -13400.0 -0.5 -0.5193 -0.9376 1633418 TimTec1_000903 Oc1cc(O)c2sc3nc(ccc3c2n1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J02 compound treatment 118560.0 5610.0 0.22 119000.0 -4570.0 -0.17 0.0324 0.1171 1297117 TimTec1_000904 Nc1ccc(cc1)c2cc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J03 compound treatment 112480.0 -473.0 -0.02 110760.0 -12800.0 -0.48 -0.353 -0.7335 3082596 TimTec1_000905 Sc1n[nH]nc1c2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J04 compound treatment 127320.0 14400.0 0.56 141560.0 18000.0 0.68 0.8715 0.9955 3209347 TimTec1_000906 CCOC(=O)c1ccc(cc1)S(=O)(=O)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J05 compound treatment 74080.0 -38900.0 -1.51 62840.0 -60700.0 -2.28 -2.6783 -0.9799 1207815 TimTec1_000907 CC1C=C(C)C2C(C)C1COC2c3ccccc3OCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J06 compound treatment 111080.0 -1870.0 -0.07 118960.0 -4610.0 -0.17 -0.1738 -0.9256 1614670 TimTec1_000908 CC1CCCCN1S(=O)(=O)c2ccc(N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J07 compound treatment 35520.0 -77400.0 -3.0 34160.0 -89400.0 -3.36 -4.4974 -0.9985 1620705 TimTec1_000909 CC1CC2=C(CC1(CO)CO)C(C)(C)CCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J08 compound treatment 78720.0 -34200.0 -1.33 87720.0 -35900.0 -1.35 -1.8907 -1.0 1432678 TimTec1_000910 Nc1cccc(c1)c2nc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J09 compound treatment 7000.0 -106000.0 -4.11 8040.0 -116000.0 -4.34 -5.9731 -0.9996 1679574 TimTec1_000911 Brc1ccc(cc1)C(=O)N2CCC(Cc3ccccc3)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J10 compound treatment 7000.0 -106000.0 -4.11 7160.0 -116000.0 -4.37 -5.9964 -0.9995 1513995 TimTec1_000912 CCCc1ccc(O)c(N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J11 compound treatment 58800.0 -54200.0 -2.1 43680.0 -79900.0 -3.0 -3.606 -0.9849 1491173 TimTec1_000913 CC(=O)OC1CCC2(C)C3CCC4(C)C(CCC4=O)C3CC=C2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J12 compound treatment 123120.0 10200.0 0.39 123840.0 266.0 0.01 0.286 0.7248 3082639 TimTec1_000914 OC1(CCCCC1)/C=C/CN2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J13 compound treatment 134960.0 22000.0 0.85 131680.0 8110.0 0.3 0.8189 0.9034 3179906 TimTec1_000915 CC[C@]1(CCCN2CC[C@]3([C@H]4CC1)c5cccc(OC)c5N4C(=O)C)[C@@H]23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J14 compound treatment 100440.0 -12500.0 -0.49 105520.0 -18100.0 -0.68 -0.8224 -0.9866 3082641 TimTec1_000916 CC1=[N+](CCC#N)c2ccccc2C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J15 compound treatment 69200.0 -43800.0 -1.7 59200.0 -64400.0 -2.42 -2.9088 -0.9851 1205123 TimTec1_000917 Cc1cccc(SCC(=O)Nc2ccc3OCCOc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J16 compound treatment 116240.0 3290.0 0.13 115640.0 -7930.0 -0.3 -0.1204 -0.3716 3082643 TimTec1_000918 SC(=S)N1CCCCC1c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J17 compound treatment 116080.0 3130.0 0.12 117400.0 -6170.0 -0.23 -0.0781 -0.2984 3209348 TimTec1_000919 CCOc1ccc(cc1)C(=O)CC(N)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J18 compound treatment 121320.0 8370.0 0.32 121160.0 -2410.0 -0.09 0.1655 0.491 1146682 TimTec1_000920 O=C1N(CCN2CC3CC(C2)c4cccc(=O)n4C3)C(=O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J19 compound treatment 118680.0 5730.0 0.22 122360.0 -1210.0 -0.05 0.1249 0.5506 1708504 TimTec1_000921 NCCOc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J20 compound treatment 19640.0 -93300.0 -3.62 21880.0 -102000.0 -3.82 -5.259 -0.9997 1179648 TimTec1_000922 CN(C)c1ccc(cc1)C2NC(=S)NC(=C2C(=O)OCCc3ccccc3)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J21 compound treatment 113840.0 887.0 0.03 110520.0 -13100.0 -0.49 -0.3221 -0.6558 3082646 TimTec1_000923 NC(=N)SCc1csc(N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J22 compound treatment 10400.0 -103000.0 -3.98 7560.0 -116000.0 -4.35 -5.8925 -0.999 3082648 TimTec1_000924 C(Sc1cccc2cccnc12)c3nnc(o3)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J23 mock treatment 122440.0 9490.0 0.37 111160.0 -12400.0 -0.47 -0.0692 -0.1165 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 J24 mock treatment 100160.0 -12800.0 -0.5 120440.0 -3130.0 -0.12 -0.4342 -0.8511 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K01 compound treatment 62000.0 -51000.0 -1.98 79480.0 -44100.0 -1.65 -2.5682 -0.9961 1262368 TimTec1_000925 CC(C)(C)NC(=O)CC(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K02 compound treatment 50800.0 -62200.0 -2.41 69120.0 -54500.0 -2.04 -3.1504 -0.9966 1207448 TimTec1_000926 CCc1nc2n(ncc2c(=O)n1CCc3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K03 compound treatment 8000.0 -105000.0 -4.07 74120.0 -49500.0 -1.86 -4.1919 -0.9367 1458877 TimTec1_000927 COc1ccc(cc1S(=O)(=O)Nc2ccc(Cl)cc2)C(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K04 compound treatment 8000.0 -105000.0 -4.07 15840.0 -108000.0 -4.04 -5.7386 -1.0 3082651 TimTec1_000928 COc1ccc(cc1N)S(=O)(=O)C=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K05 compound treatment 105880.0 -7070.0 -0.27 111800.0 -11800.0 -0.44 -0.5065 -0.9737 3209349 TimTec1_000929 O=C1CCCC(Cn2cncn2)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K06 compound treatment 65000.0 -48000.0 -1.86 62240.0 -61300.0 -2.3 -2.9434 -0.9944 1111413 TimTec1_000930 O=C(N(c1ccccc1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K07 compound treatment 117440.0 4490.0 0.17 130600.0 7030.0 0.26 0.3096 0.9797 3082653 TimTec1_000931 CCC1=CC(NC(=S)N1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K08 compound treatment 78680.0 -34300.0 -1.33 100040.0 -23500.0 -0.88 -1.5649 -0.9802 3209350 TimTec1_000932 Oc1ccccc1/C=N/c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K09 compound treatment 81920.0 -31000.0 -1.2 97280.0 -26300.0 -0.99 -1.5492 -0.9951 3082655 TimTec1_000933 CCc1ccc(OCCNC(=O)c2ccco2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K10 compound treatment 34000.0 -79000.0 -3.06 47800.0 -75800.0 -2.84 -4.1771 -0.9993 1604140 TimTec1_000934 Clc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K11 compound treatment 82520.0 -30400.0 -1.18 93160.0 -30400.0 -1.14 -1.6421 -0.9999 1651876 TimTec1_000935 CNC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K12 compound treatment 108240.0 -4710.0 -0.18 113400.0 -10200.0 -0.38 -0.3993 -0.9432 3082657 TimTec1_000936 Cc1onc(c1C(=O)NC2=NCCS2)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K13 compound treatment 79960.0 -33000.0 -1.28 82240.0 -41300.0 -1.55 -2.0022 -0.9954 3209351 TimTec1_000937 Clc1ccc(/C=N\n2cnnc2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K14 compound treatment 75680.0 -37300.0 -1.45 84840.0 -38700.0 -1.45 -2.0506 -1.0 1479829 TimTec1_000938 Brc1ccc(cc1)S(=O)(=O)NCC2CCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K15 compound treatment 25600.0 -87400.0 -3.39 20160.0 -103000.0 -3.88 -5.1411 -0.9977 3209352 TimTec1_000939 COc1ccc(/C=N/c2ccc(Br)cc2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K16 compound treatment 46160.0 -66800.0 -2.59 46240.0 -77300.0 -2.9 -3.8849 -0.9984 1308008 TimTec1_000940 CCN(c1ccccc1)S(=O)(=O)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K17 compound treatment 68680.0 -44300.0 -1.72 69360.0 -54200.0 -2.03 -2.6535 -0.9965 1918619 TimTec1_000941 CCOC(=O)c1ccc(/N=C/c2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K18 compound treatment 105880.0 -7070.0 -0.27 111520.0 -12100.0 -0.45 -0.514 -0.9713 1453153 TimTec1_000942 COC(=O)c1cc(NC(=O)c2ccco2)cc(c1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K19 compound treatment 108400.0 -4550.0 -0.18 109960.0 -13600.0 -0.51 -0.4862 -0.8993 3209353 TimTec1_000943 Nc1nc2c3cc4CCCc4nc3sc2c(c1C#N)c5ccc(Br)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K20 compound treatment 118680.0 5730.0 0.22 121360.0 -2210.0 -0.08 0.0984 0.4146 1246610 TimTec1_000944 Cc1cccc(N2C(=O)c3ccc(cc3C2=O)C(=O)Nc4c[nH]c(=O)[nH]c4=O)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K21 compound treatment 97560.0 -15400.0 -0.6 88600.0 -35000.0 -1.31 -1.3505 -0.9365 1512817 TimTec1_000945 Cc1ccc(cc1)n2c(C)nc3sc4CCCc4c3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K22 compound treatment 100360.0 -12600.0 -0.49 94320.0 -29300.0 -1.1 -1.1219 -0.9335 3209354 TimTec1_000946 NC(=O)C(C(C(C#N)C#N)c1ccccc1Cl)[n+]2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K23 mock treatment 124320.0 11400.0 0.44 121800.0 -1770.0 -0.07 0.2648 0.5936 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 K24 mock treatment 101480.0 -11500.0 -0.45 115600.0 -7970.0 -0.3 -0.5264 -0.9813 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L01 compound treatment 4280.0 -109000.0 -4.22 4880.0 -119000.0 -4.45 -6.1316 -0.9996 1381598 TimTec1_000947 NC(=O)c1c(c(C#N)c(N)[nH]c1=S)c2cccc(Br)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L02 compound treatment 100320.0 -12600.0 -0.49 110360.0 -13200.0 -0.5 -0.6973 -1.0 1609999 TimTec1_000948 COC(=O)C1CCCN1S(=O)(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L03 compound treatment 110800.0 -2150.0 -0.08 117960.0 -5610.0 -0.21 -0.2081 -0.9179 1730347 TimTec1_000949 Cc1cccc(c1)C(=O)Nc2ccc3[nH]c(O)nc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L04 compound treatment 116760.0 3810.0 0.15 119880.0 -3690.0 -0.14 0.0064 0.0317 1111506 TimTec1_000950 OC(=O)CCc1ccc(F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L05 compound treatment 76040.0 -36900.0 -1.43 74240.0 -49300.0 -1.85 -2.322 -0.9919 3209355 TimTec1_000951 FC(F)(F)c1cc(nc2c(Cl)c(nn12)C(=O)N3CCCc4ccccc34)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L06 compound treatment 116280.0 3330.0 0.13 126200.0 2630.0 0.1 0.161 0.9911 1321261 TimTec1_000952 CC(CO)(CO)NS(=O)(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L07 compound treatment 40520.0 -72400.0 -2.81 47600.0 -76000.0 -2.85 -4.0035 -1.0 3209356 TimTec1_000953 CCOC(=O)C1=C(N)n2c(=O)/c(=C\c3ccco3)/sc2=C(C1c4ccco4)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L08 compound treatment 44080.0 -68900.0 -2.67 48520.0 -75100.0 -2.82 -3.8814 -0.9997 1024363 TimTec1_000954 Nc1ccc(cc1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L09 compound treatment 96840.0 -16100.0 -0.63 101480.0 -22100.0 -0.83 -1.0284 -0.9903 1663099 TimTec1_000955 CCN(C(=O)c1cccc(c1)C(=O)N(CC)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L10 compound treatment 113240.0 287.0 0.01 117240.0 -6330.0 -0.24 -0.1602 -0.6732 1061459 TimTec1_000956 CN(c1ccccc1)S(=O)(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L11 compound treatment 115480.0 2530.0 0.1 121440.0 -2130.0 -0.08 0.0127 0.1003 1730887 TimTec1_000957 CCOC(=O)c1csc(N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L12 compound treatment 8720.0 -104000.0 -4.04 8200.0 -115000.0 -4.33 -5.9216 -0.9994 1709522 TimTec1_000958 O=C(OC1(CCCCC1)C#CCN2CCCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L13 compound treatment 59800.0 -53200.0 -2.06 63360.0 -60200.0 -2.26 -3.0563 -0.999 1685514 TimTec1_000959 CCC1(CCCN2CCC3(C4CC1)c5ccc(OC)c(O)c5N4C(=O)C)C23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L14 compound treatment 44800.0 -68200.0 -2.64 47560.0 -76000.0 -2.85 -3.8872 -0.9993 1920479 TimTec1_000960 Oc1ccc(/C=N/c2nccs2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L15 compound treatment 40680.0 -72300.0 -2.8 35480.0 -88100.0 -3.31 -4.3208 -0.9966 3082723 TimTec1_000961 CC(C)Cn1c(SCC(=O)c2ccc(Cl)cc2)nc3ccccc3c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L16 compound treatment 71240.0 -41700.0 -1.62 73520.0 -50100.0 -1.88 -2.4728 -0.9972 3209357 TimTec1_000962 Oc1ccc(/C=N/CC2CCCN3CCCCC23)c(O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L17 compound treatment 66080.0 -46900.0 -1.82 70520.0 -53100.0 -1.99 -2.694 -0.999 3082725 TimTec1_000963 OC(=O)C(CC(=O)c1ccc(Cl)cc1)NC2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L18 compound treatment 102600.0 -10400.0 -0.4 115160.0 -8410.0 -0.32 -0.5073 -0.9929 1466736 TimTec1_000964 O=C1N(CCN2CCCCC2)C(=O)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L19 compound treatment 105880.0 -7070.0 -0.27 114760.0 -8810.0 -0.33 -0.428 -0.9957 3082726 TimTec1_000965 CC(=O)NCCOc1ccccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L20 compound treatment 108880.0 -4070.0 -0.16 109200.0 -14400.0 -0.54 -0.4932 -0.8774 3209478 TimTec1_000966 COC(=O)C1=C(C)N(C)C(=O)NC1c2ccc(OC)c(Br)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L21 compound treatment 97920.0 -15000.0 -0.58 97160.0 -26400.0 -0.99 -1.1134 -0.968 3082728 TimTec1_000967 COc1cccc(c1)c2csc3[nH]cnc(=O)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L22 compound treatment 114720.0 1770.0 0.07 110480.0 -13100.0 -0.49 -0.299 -0.6026 1136019 TimTec1_000968 CN(C)c1ccc(cc1)C2NCC(CSc3nc4ccccc4s3)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L23 mock treatment 113480.0 527.0 0.02 119240.0 -4330.0 -0.16 -0.1006 -0.6134 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 L24 mock treatment 92400.0 -20600.0 -0.8 119920.0 -3650.0 -0.14 -0.6609 -0.8167 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M01 compound treatment 44600.0 -68400.0 -2.65 75920.0 -47700.0 -1.79 -3.14 -0.9816 1453808 TimTec1_000969 O=C(CC(c1ccccc1)c2ccccc2)NC3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M02 compound treatment 5160.0 -108000.0 -4.18 6000.0 -118000.0 -4.41 -6.0777 -0.9996 1706729 TimTec1_000970 Cc1csc(NC(=O)CSc2nc(ccc2C#N)C3(CC4CC5CC(C4)C3)C5)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M03 compound treatment 50080.0 -62900.0 -2.44 102000.0 -21600.0 -0.81 -2.2975 -0.8939 1282202 TimTec1_000971 CC1CN(CC(C)O1)S(=O)(=O)c2cccc(c2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M04 compound treatment 43640.0 -69300.0 -2.69 72520.0 -51100.0 -1.92 -3.2566 -0.9862 3082794 TimTec1_000972 Nc1ccc(Cc2ccc(N)c(C#N)c2)cc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M05 compound treatment 94400.0 -18600.0 -0.72 95000.0 -28600.0 -1.07 -1.2673 -0.9812 3209479 TimTec1_000973 FC(F)(F)c1cc(nc2c(cnn12)C(=O)NCC=C)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M06 compound treatment 75080.0 -37900.0 -1.47 65440.0 -58100.0 -2.18 -2.5819 -0.9815 1356106 TimTec1_000974 CN(C)c1cc(O)c(C(=S)Nc2ccccc2)c(c1)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M07 compound treatment 63600.0 -49400.0 -1.91 60840.0 -62700.0 -2.35 -3.0189 -0.9947 1632278 TimTec1_000975 CC(Sc1ncnc2[nH]cnc12)c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M08 compound treatment 84440.0 -28500.0 -1.11 108400.0 -15200.0 -0.57 -1.185 -0.9523 3082797 TimTec1_000976 COc1ccc(/C=N/c2ccccc2C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M09 compound treatment 69040.0 -43900.0 -1.7 125120.0 1550.0 0.06 -1.1638 -0.6826 3209480 TimTec1_000977 Cc1ccccc1OCCNC(=O)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M10 compound treatment 94760.0 -18200.0 -0.71 100000.0 -23600.0 -0.88 -1.1248 -0.9937 1332157 TimTec1_000978 COc1ccc(NC(=O)c2cccc(C)c2)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M11 compound treatment 82240.0 -30700.0 -1.19 87880.0 -35700.0 -1.34 -1.7899 -0.9983 3209481 TimTec1_000979 NNC(=O)CCCSc1nc2ccccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M12 compound treatment 117080.0 4130.0 0.16 119640.0 -3930.0 -0.15 0.0088 0.0405 3082799 TimTec1_000980 Cc1ccccc1C(=O)NC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M13 compound treatment 99320.0 -13600.0 -0.53 103840.0 -19700.0 -0.74 -0.8978 -0.9864 1494508 TimTec1_000981 Cc1ccc(NC(=O)n2ccnc2)cc1NC(=O)n3ccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M14 compound treatment 50160.0 -62800.0 -2.44 45080.0 -78500.0 -2.95 -3.8059 -0.9955 1306757 TimTec1_000982 CN(C1CCCCC1)S(=O)(=O)c2cc(Cl)ccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M15 compound treatment 26920.0 -86000.0 -3.34 20840.0 -103000.0 -3.86 -5.0868 -0.9974 3082802 TimTec1_000983 COc1ccc(/C=N/c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M16 compound treatment 33920.0 -79000.0 -3.07 30360.0 -93200.0 -3.5 -4.6421 -0.9978 1154044 TimTec1_000984 COc1ccc(cc1)S(=O)(=O)N2CCc3ccccc3C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M17 compound treatment 101000.0 -12000.0 -0.46 106960.0 -16600.0 -0.62 -0.7689 -0.9894 3082804 TimTec1_000985 Fc1ccc(/C=N/c2ccc3ccccc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M18 compound treatment 82280.0 -30700.0 -1.19 82960.0 -40600.0 -1.52 -1.9194 -0.9925 1441763 TimTec1_000986 CCOC(=O)c1ccc(NC(=O)c2ccco2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M19 compound treatment 77280.0 -35700.0 -1.38 77440.0 -46100.0 -1.73 -2.2031 -0.9938 1358509 TimTec1_000987 CN1CCc2nc3sc(C(=O)C(C)(C)C)c(N)c3cc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M20 compound treatment 106960.0 -5990.0 -0.23 110760.0 -12800.0 -0.48 -0.5045 -0.9444 1432076 TimTec1_000988 Clc1ccc(NC(=O)CCN2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M21 compound treatment 109040.0 -3910.0 -0.15 114320.0 -9250.0 -0.35 -0.3529 -0.9311 1556893 TimTec1_000989 CCOC(=O)c1cnn(c1NC(=O)C(C)(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M22 compound treatment 103920.0 -9030.0 -0.35 107760.0 -15800.0 -0.59 -0.6675 -0.9684 3209482 TimTec1_000990 C[C@]1(O)NC(=C(C#N)C(C1[n+]2ccccc2)c3ccc(Cl)cc3)S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M23 mock treatment 105400.0 -7550.0 -0.29 114480.0 -9090.0 -0.34 -0.4486 -0.9971 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 M24 mock treatment 95680.0 -17300.0 -0.67 119320.0 -4250.0 -0.16 -0.5868 -0.8517 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N01 compound treatment 70400.0 -42600.0 -1.65 77080.0 -46500.0 -1.75 -2.4014 -0.9996 1633893 TimTec1_000991 Oc1cccc(c1)C2=NC(=O)c3ccccc3Nc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N02 compound treatment 76440.0 -36500.0 -1.42 73280.0 -50300.0 -1.89 -2.3365 -0.99 1083978 TimTec1_000992 CCOC(=O)Nc1ccc(Cl)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N03 compound treatment 94920.0 -18000.0 -0.7 109160.0 -14400.0 -0.54 -0.8773 -0.9919 1379055 TimTec1_000993 CC(=O)OC1C2CCC1C(CC2)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N04 compound treatment 110160.0 -2790.0 -0.11 103920.0 -19700.0 -0.74 -0.5982 -0.8024 1041245 TimTec1_000994 NNC(=O)CCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N05 compound treatment 96760.0 -16200.0 -0.63 100600.0 -23000.0 -0.86 -1.054 -0.9879 1709635 TimTec1_000995 O=C(Nc1ccccc1)OC2C3CCCC2C(CC3)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N06 compound treatment 83000.0 -30000.0 -1.16 81840.0 -41700.0 -1.57 -1.9294 -0.9892 1189065 TimTec1_000996 Cc1ccc(C)c(NS(=O)(=O)c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N07 compound treatment 39440.0 -73500.0 -2.85 36560.0 -87000.0 -3.27 -4.3262 -0.9977 1163480 TimTec1_000997 CC(=O)NC1C(=O)N(Cc2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N08 compound treatment 40760.0 -72200.0 -2.8 39120.0 -84500.0 -3.17 -4.222 -0.9981 1111758 TimTec1_000998 Nc1ccc(cc1)c2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N09 compound treatment 86440.0 -26500.0 -1.03 83320.0 -40300.0 -1.51 -1.7957 -0.9825 1140426 TimTec1_000999 CN(Cc1ccccc1)C(=O)c2cccc(c2)C(=O)N(C)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N10 compound treatment 98600.0 -14400.0 -0.56 96160.0 -27400.0 -1.03 -1.1213 -0.9584 1327404 TimTec1_001000 COc1ccc(cc1)C(=O)NC(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N11 compound treatment 63400.0 -49600.0 -1.92 67880.0 -55700.0 -2.09 -2.8376 -0.9991 3209483 TimTec1_001001 COCC(=O)Nc1cc(Sc2ccccc2)ccc1N=C(NC(=O)C)NC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N12 compound treatment 107440.0 -5510.0 -0.21 108400.0 -15200.0 -0.57 -0.554 -0.9106 1566798 TimTec1_001002 CCC(CC)(CN(C)C)OC(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N13 compound treatment 105480.0 -7470.0 -0.29 119520.0 -4050.0 -0.15 -0.3126 -0.9547 3209484 TimTec1_001003 CCCN1CC2(COC)CC[C@H](OC)[C@]3(CC[C@H](COC)[C@@H](O)C[C@@](C)(O)C4(O)[C@@H](OC)[C@@H]32)[C@@H]14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N14 compound treatment 53480.0 -59500.0 -2.31 51680.0 -71900.0 -2.7 -3.5397 -0.997 3082877 TimTec1_001004 Clc1ccc(/C=N/c2ccccn2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N15 compound treatment 10800.0 -102000.0 -3.96 7320.0 -116000.0 -4.36 -5.8879 -0.9989 3082878 TimTec1_001005 OC(=O)C(CC(=O)c1ccc(cc1)C2CCCCC2)N3CCN(CC3)c4cccc(Cl)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N16 compound treatment 81160.0 -31800.0 -1.23 83240.0 -40300.0 -1.51 -1.9427 -0.9948 1649522 TimTec1_001006 O=C1NC(=O)C(CC2CCCN3CCCCC23)C(=O)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N17 compound treatment 92560.0 -20400.0 -0.79 99960.0 -23600.0 -0.89 -1.1862 -0.9984 3209485 TimTec1_001007 CN(C)/C=N/c1n[nH]c(Nc2ccc(C)c(C)c2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N18 compound treatment 86920.0 -26000.0 -1.01 91080.0 -32500.0 -1.22 -1.5766 -0.9956 1153859 TimTec1_001008 C[N+]12CCCCC2C(CN3C(=O)c4ccccc4C3=O)CCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N19 compound treatment 36280.0 -76700.0 -2.97 34520.0 -89100.0 -3.34 -4.467 -0.9983 3082882 TimTec1_001009 CC(=O)NCCOc1ccc(cc1)C2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N20 compound treatment 57120.0 -55800.0 -2.17 56560.0 -67000.0 -2.52 -3.3103 -0.9972 1577050 TimTec1_001010 CCc1ccc(cc1)C2C(=C(C)NC3=C2C(=O)CC(C)(C)C3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N21 compound treatment 109080.0 -3870.0 -0.15 107560.0 -16000.0 -0.6 -0.5313 -0.8575 3082884 TimTec1_001011 COC(=O)c1ccccc1N(C)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N22 compound treatment 87720.0 -25200.0 -0.98 86200.0 -37400.0 -1.4 -1.6842 -0.9845 3209486 TimTec1_001012 CN(C)c1ccc(cc1)C2NCC(CSc3nc(cc(c3C#N)C(F)(F)F)c4cccs4)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N23 mock treatment 109200.0 -3750.0 -0.15 126640.0 3070.0 0.12 -0.0216 -0.1164 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 N24 mock treatment 98840.0 -14100.0 -0.55 121520.0 -2050.0 -0.08 -0.4417 -0.7988 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O01 compound treatment 50640.0 -62300.0 -2.42 76880.0 -46700.0 -1.75 -2.9488 -0.9875 1716121 TimTec1_001013 Clc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O02 compound treatment 5160.0 -108000.0 -4.18 23320.0 -100000.0 -3.76 -5.618 -0.9986 3209487 TimTec1_001014 CCOC(=O)C(C)Sc1nc(ccc1C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O03 compound treatment 15000.0 -98000.0 -3.8 56560.0 -67000.0 -2.52 -4.4659 -0.9799 1595818 TimTec1_001015 O=S(=O)(NC1CCCCC1)c2cccc(c2)c3nnc(o3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O04 compound treatment 95000.0 -18000.0 -0.7 97920.0 -25700.0 -0.96 -1.1734 -0.9874 1004440 TimTec1_001016 COC(=O)c1ccc(cc1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O05 compound treatment 98320.0 -14600.0 -0.57 94760.0 -28800.0 -1.08 -1.1662 -0.9548 1455776 TimTec1_001017 OC(=O)CCC(=O)Nc1ccc(Cc2ccncc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O06 compound treatment 88760.0 -24200.0 -0.94 104360.0 -19200.0 -0.72 -1.1737 -0.9915 3082886 TimTec1_001018 COC1OC(C)C(OCc2ccccc2)C(O)C1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O07 compound treatment 64800.0 -48200.0 -1.87 86720.0 -36900.0 -1.38 -2.2992 -0.9891 1682147 TimTec1_001019 CN(C)C(=O)CSc1nnc(N)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O08 compound treatment 67000.0 -46000.0 -1.78 92280.0 -31300.0 -1.17 -2.0913 -0.9795 3082888 TimTec1_001020 OC(=O)c1ccccc1/N=C/c2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O09 compound treatment 12160.0 -101000.0 -3.91 35520.0 -88100.0 -3.3 -5.1022 -0.9965 1398146 TimTec1_001021 O=C(CC1c2ccccc2Oc3ccccc13)Nc4ccccn4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O10 compound treatment 54480.0 -58500.0 -2.27 69000.0 -54600.0 -2.05 -3.0526 -0.9987 3082890 TimTec1_001022 CCN(c1cccc(C)c1)c2ccccc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O11 compound treatment 32120.0 -80800.0 -3.14 39720.0 -83900.0 -3.15 -4.4431 -1.0 3209488 TimTec1_001023 NC1=NN(C(=O)C1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O12 compound treatment 98360.0 -14600.0 -0.57 108440.0 -15100.0 -0.57 -0.802 -1.0 1608079 TimTec1_001024 COc1ccc(cc1)C(=O)N(CC#N)CC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O13 compound treatment 90000.0 -23000.0 -0.89 100560.0 -23000.0 -0.86 -1.2405 -0.9999 1340354 TimTec1_001025 CC(=O)Nc1ccc(cc1)S(=O)(=O)CCO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O14 compound treatment 71520.0 -41400.0 -1.61 81600.0 -42000.0 -1.58 -2.2507 -0.9999 1049845 TimTec1_001026 O=S(=O)(N1CCN(CC1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O15 compound treatment 63960.0 -49000.0 -1.9 49520.0 -74100.0 -2.78 -3.3095 -0.9828 3209489 TimTec1_001027 CC(=O)Nc1ccc(/N=C/c2cccc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O16 compound treatment 5320.0 -108000.0 -4.18 5440.0 -118000.0 -4.43 -6.0882 -0.9996 1685172 TimTec1_001028 CCc1ccc(NS(=O)(=O)c2ccc(OC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O17 compound treatment 20000.0 -93000.0 -3.61 14960.0 -109000.0 -4.08 -5.4328 -0.9981 1709515 TimTec1_001029 CC(NC(=O)c1sc2nc(C)cc(C)c2c1N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O18 compound treatment 75760.0 -37200.0 -1.44 95600.0 -28000.0 -1.05 -1.7628 -0.9878 3209490 TimTec1_001030 NC1=C(C#N)C(c2cccc(F)c2)n3c(=O)/c(=C\c4cccc(F)c4)/sc3=C1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O19 compound treatment 22960.0 -90000.0 -3.49 11400.0 -112000.0 -4.21 -5.446 -0.9957 1220431 TimTec1_001031 Cc1ccc(o1)C2C(=C(N)Oc3c2c(=O)oc4ccccc34)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O20 compound treatment 89520.0 -23400.0 -0.91 85440.0 -38100.0 -1.43 -1.6549 -0.976 3209602 TimTec1_001032 CC1(C)NCCC21C(=O)N(Cc3ccccc3)c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O21 compound treatment 78360.0 -34600.0 -1.34 70120.0 -53500.0 -2.01 -2.3677 -0.9809 1707435 TimTec1_001033 CCN(CC)C(=O)c1c(NC(=O)c2cccs2)sc3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O22 compound treatment 94520.0 -18400.0 -0.72 69960.0 -53600.0 -2.01 -1.9286 -0.9031 1398816 TimTec1_001034 NC1=C(C#N)C(c2ccoc2)c3c([nH]nc3O1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O23 mock treatment 102360.0 -10600.0 -0.41 103480.0 -20100.0 -0.75 -0.8239 -0.9593 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 O24 mock treatment 96520.0 -16400.0 -0.64 123520.0 -54.2 0.0 -0.4523 -0.7094 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P01 compound treatment 46640.0 -66300.0 -2.57 50640.0 -72900.0 -2.74 -3.755 -0.9995 1265807 TimTec1_001035 O=c1cc(c2ccccc2)n(cn1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P02 compound treatment 95920.0 -17000.0 -0.66 93280.0 -30300.0 -1.14 -1.2713 -0.9667 3209603 TimTec1_001036 CN1C2C(N=C1OCC=C)N(C)C(=O)N(C)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P03 compound treatment 45360.0 -67600.0 -2.62 64400.0 -59200.0 -2.22 -3.4249 -0.9966 1404718 TimTec1_001037 COc1cc(ccc1O)C2OCC3C(C)C=C(C)C2C3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P04 compound treatment 67000.0 -46000.0 -1.78 72560.0 -51000.0 -1.91 -2.6146 -0.9994 3082971 TimTec1_001038 CN1CN(C(=C1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P05 compound treatment 5040.0 -108000.0 -4.19 4720.0 -119000.0 -4.46 -6.115 -0.9995 1591413 TimTec1_001039 CC1C=C(C)C2C(C)C1(COC(=O)Nc3ccccc3)COC2c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P06 compound treatment 85080.0 -27900.0 -1.08 115560.0 -8010.0 -0.3 -0.9774 -0.8707 1353881 TimTec1_001040 C=CCC1(C2CCCC2)C(=O)NC(=O)NC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P07 compound treatment 4280.0 -109000.0 -4.22 3960.0 -120000.0 -4.49 -6.156 -0.9995 3082974 TimTec1_001041 N(=c/1\[nH]n(c[n+]1c2ccccc2)c3ccccc3)\c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P08 compound treatment 59560.0 -53400.0 -2.07 54120.0 -69500.0 -2.61 -3.3081 -0.9935 1117800 TimTec1_001042 Nc1ccc2oc(nc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P09 compound treatment 69200.0 -43800.0 -1.7 76880.0 -46700.0 -1.75 -2.4396 -0.9999 3209604 TimTec1_001043 CC1C2C(O)C3C(N(C)C)C(=C(C(=O)N)C(=O)C3(O)C(=C2Cc4c(O)cccc14)O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P10 compound treatment 68720.0 -44200.0 -1.72 61920.0 -61700.0 -2.31 -2.8498 -0.9892 1446940 TimTec1_001044 CCOc1ccc(cc1)C(=O)NC2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P11 compound treatment 29160.0 -83800.0 -3.25 26960.0 -96600.0 -3.63 -4.863 -0.9985 3082976 TimTec1_001045 FC(F)(F)c1cccc(/N=C/c2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P12 compound treatment 70320.0 -42600.0 -1.65 63880.0 -59700.0 -2.24 -2.7539 -0.9889 3209605 TimTec1_001046 CC[N+](C)(CC)C/C=C\1/COCO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P13 compound treatment 87720.0 -25200.0 -0.98 83360.0 -40200.0 -1.51 -1.7595 -0.978 1357190 TimTec1_001047 COc1ccc(CC(=O)N(CC#N)CC#N)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P14 compound treatment 61200.0 -51800.0 -2.01 53080.0 -70500.0 -2.65 -3.2907 -0.9907 3082979 TimTec1_001048 C1OCc2cccc(/C=N/c3nccs3)c2O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P15 compound treatment 72800.0 -40200.0 -1.56 75920.0 -47700.0 -1.79 -2.3663 -0.9976 3209606 TimTec1_001049 Cc1cc(C)nc(SCc2nc3ccccc3c(=O)n2c4ccc(cc4)C(F)(F)F)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P16 compound treatment 91160.0 -21800.0 -0.85 97280.0 -26300.0 -0.99 -1.2957 -0.997 2110705 TimTec1_001050 CN(C)c1ccc(/C=N/CC2CCCN3CCCCC23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P17 compound treatment 85600.0 -27400.0 -1.06 79480.0 -44100.0 -1.65 -1.9207 -0.9769 3082982 TimTec1_001051 OC(=O)C(CC(=O)c1ccc(Br)cc1)NCCc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P18 compound treatment 84400.0 -28600.0 -1.11 83760.0 -39800.0 -1.49 -1.84 -0.9892 3209607 TimTec1_001052 OC(=O)c1cc(/C=N/c2ccc(cc2)S(=O)(=O)NC3NC=CS3)c4OCOCc4c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P19 compound treatment 40720.0 -72200.0 -2.8 38800.0 -84800.0 -3.18 -4.2316 -0.998 1482831 TimTec1_001053 CN(c1cccc2cccnc12)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P20 compound treatment 62600.0 -50400.0 -1.95 63640.0 -59900.0 -2.25 -2.9721 -0.9975 1207395 TimTec1_001054 CC(C)COC(=O)C1=C(C)N(C)C(=O)NC1c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P21 compound treatment 34320.0 -78600.0 -3.05 32160.0 -91400.0 -3.43 -4.5834 -0.9983 3082984 TimTec1_001055 Cn1c(S)nc2sc3CC(CCc3c2c1=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P22 compound treatment 5680.0 -107000.0 -4.16 6160.0 -117000.0 -4.41 -6.0592 -0.9996 3209608 TimTec1_001056 CCN(CC)C(=S)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P23 mock treatment 93560.0 -19400.0 -0.75 107800.0 -15800.0 -0.59 -0.9507 -0.993 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2065 P24 mock treatment 92120.0 -20800.0 -0.81 103880.0 -19700.0 -0.74 -1.0942 -0.999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A01 compound treatment 14080.0 -97100.0 -3.77 5840.0 -93800.0 -3.52 -5.1533 -0.9994 3209609 TimTec1_001057 FC(F)(F)c1cc(NC(=O)C(=S)N2CCCCC2)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A02 compound treatment 124680.0 13500.0 0.52 90440.0 -9150.0 -0.34 0.1263 0.2021 3082986 TimTec1_001058 CCN1C(=C(C#N)C2(CCNCC2)c3nc(C)oc13)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A03 compound treatment 51440.0 -59800.0 -2.32 52080.0 -47500.0 -1.78 -2.9011 -0.9916 3082988 TimTec1_001059 Oc1cccc(/C=C\2/NC(=S)SC2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A04 compound treatment 6240.0 -105000.0 -4.07 5280.0 -94300.0 -3.54 -5.3833 -0.9976 3209610 TimTec1_001060 CCCc1nc2C(C(=C(N)Nc2o1)C#N)c3cnn(c3C)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A05 compound treatment 124560.0 13300.0 0.52 85480.0 -14100.0 -0.53 -0.0086 -0.0117 1135930 TimTec1_001061 O=C(NCCN1CCCCC1)Nc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A06 compound treatment 33440.0 -77800.0 -3.02 35360.0 -64200.0 -2.41 -3.8387 -0.9938 1680573 TimTec1_001062 COc1cc(OC)cc(c1)C(C(C#N)C#N)c2nc(C)[nH]c2O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A07 compound treatment 157680.0 46500.0 1.8 93400.0 -6190.0 -0.23 1.1102 0.6109 3209611 TimTec1_001063 CCOC(=O)C(N)Cc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A08 compound treatment 88280.0 -22900.0 -0.89 62640.0 -37000.0 -1.39 -1.6102 -0.977 1656439 TimTec1_001064 CCN(CC)C(=S)CSc1nc(cc(c2ccco2)c1C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A09 compound treatment 95000.0 -16200.0 -0.63 75000.0 -24600.0 -0.92 -1.0978 -0.9826 1709298 TimTec1_001065 COc1ccc2CCC(CC3(O)C(=O)N(C)c4ccccc43)C(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A10 compound treatment 113400.0 2180.0 0.08 86640.0 -13000.0 -0.49 -0.284 -0.5757 1586331 TimTec1_001066 CC1=CC(c2ccoc2)c3c(S1)oc(N)c(C#N)c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A11 compound treatment 8320.0 -103000.0 -3.99 5800.0 -93800.0 -3.52 -5.3124 -0.998 3083064 TimTec1_001067 Fc1ccc(CSC(=C(C#N)C#N)Nc2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A12 compound treatment 152560.0 41300.0 1.6 107560.0 7970.0 0.3 1.3456 0.8248 3209612 TimTec1_001068 CCCN1CC=C2C(C#N)(C#N)C(=C(C)[C@H](c3ccc(cc3)C(=O)OC)[C@@]2(C)C1)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A13 compound treatment 45520.0 -65700.0 -2.55 36320.0 -63300.0 -2.37 -3.4818 -0.9994 1679027 TimTec1_001069 CC(C)Oc1ccc(cc1)C2C(=C(N)N(c3oc(C)nc23)c4ccccc4)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A14 compound treatment 153800.0 42600.0 1.65 102840.0 3250.0 0.12 1.2543 0.7572 3209613 TimTec1_001070 CC(C)(C)C1CC=C2[C@H](C1)[C@H](C(=C(N)C2(C#N)C#N)C#N)c3ccsc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A15 compound treatment 124600.0 13400.0 0.52 94760.0 -4830.0 -0.18 0.2387 0.4343 3209614 TimTec1_001071 CN1C2CCC1[C@@H]3[C@H](C(=C(N)C(C#N)(C#N)C3=C2)C#N)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A16 compound treatment 89360.0 -21900.0 -0.85 84480.0 -15100.0 -0.57 -1.0009 -0.9808 1128630 TimTec1_001072 COc1cc(OC)cc(c1)C2SC(=C(C#N)C(=C2C#N)N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A17 compound treatment 147240.0 36000.0 1.4 120280.0 20700.0 0.78 1.5372 0.9615 3083068 TimTec1_001073 COC(=O)C1=C(N)OC2=C(CCCC2=O)C1c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A18 compound treatment 154560.0 43300.0 1.68 112760.0 13200.0 0.49 1.5384 0.8778 3209615 TimTec1_001074 Clc1cccc(c1)C(=O)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A19 compound treatment 152840.0 41600.0 1.61 114040.0 14400.0 0.54 1.5252 0.8954 1165075 TimTec1_001075 CCOC(=O)C1=C(S)N(C#N)C(=O)C(C#N)C21CCNCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A20 compound treatment 112760.0 1540.0 0.06 94360.0 -5230.0 -0.2 -0.0967 -0.4714 3083071 TimTec1_001076 CC(NC(=O)c1ccc(cc1)C(C)(C)C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A21 compound treatment 7640.0 -104000.0 -4.02 6920.0 -92700.0 -3.48 -5.3013 -0.9974 1594569 TimTec1_001077 CCOC(=O)C1=C(N)OC(=C(C#N)C1c2ccccc2)c3cccc(OC)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A22 compound treatment 102080.0 -9150.0 -0.35 93480.0 -6110.0 -0.23 -0.4131 -0.9777 1190176 TimTec1_001078 CCOC(=O)C1CCCn2c1nc3sc4CCCCc4c3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A23 mock treatment 137920.0 26700.0 1.04 123720.0 24100.0 0.91 1.3728 0.9978 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 A24 mock treatment 100800.0 -10400.0 -0.4 103840.0 4250.0 0.16 -0.1733 -0.3985 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B01 compound treatment 138040.0 26800.0 1.04 127160.0 27600.0 1.03 1.4673 1.0 3209616 TimTec1_001079 O=c1oc(nc2scc(c3ccccc3)c12)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B02 compound treatment 28520.0 -82700.0 -3.21 34640.0 -65000.0 -2.44 -3.9928 -0.9908 1252791 TimTec1_001080 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccco4)C(=S)Nc5cccc(Cl)c5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B03 compound treatment 141480.0 30300.0 1.17 116080.0 16500.0 0.62 1.2677 0.9553 3083074 TimTec1_001081 CCC(C)NC(=O)CSc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B04 compound treatment 95720.0 -15500.0 -0.6 93520.0 -6070.0 -0.23 -0.5865 -0.9117 3083076 TimTec1_001082 O=C(CCCCn1cnc2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B05 compound treatment 148000.0 36800.0 1.43 130360.0 30800.0 1.15 1.8255 0.9945 1133090 TimTec1_001083 C1CC2=C(Nc3ncnn3C2c4ccccc4)c5ccccc5C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B06 compound treatment 191440.0 80200.0 3.11 163560.0 64000.0 2.4 3.8984 0.9918 1354657 TimTec1_001084 CC1CN(C)C(C(C)C21NC(=O)NC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B07 compound treatment 29040.0 -82200.0 -3.19 33480.0 -66100.0 -2.48 -4.0093 -0.9923 3083078 TimTec1_001085 Clc1cnn(Cc2ccccc2)c(=S)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B08 compound treatment 170920.0 59700.0 2.32 171760.0 72200.0 2.71 3.5531 0.997 3209617 TimTec1_001086 OC(=O)[C@H]1NC(=O)C1Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B09 compound treatment 9000.0 -102000.0 -3.97 7560.0 -92000.0 -3.45 -5.247 -0.9976 1612069 TimTec1_001087 Nc1sc2CCCc2c1C(=O)Nc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B10 compound treatment 104320.0 -6910.0 -0.27 95040.0 -4550.0 -0.17 -0.3102 -0.9764 3083081 TimTec1_001088 CC/1=NN(C(=O)\C1=C\2/C(=O)Nc3ccccc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B11 compound treatment 129760.0 18500.0 0.72 118120.0 18500.0 0.7 1.0003 0.9999 1674088 TimTec1_001089 Nn1c(nc2ccccc2c1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B12 compound treatment 71960.0 -39300.0 -1.52 66800.0 -32800.0 -1.23 -1.9475 -0.9944 1517968 TimTec1_001090 O=C(N1CCc2ccccc12)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B13 compound treatment 7520.0 -104000.0 -4.02 6240.0 -93400.0 -3.5 -5.3227 -0.9976 1537974 TimTec1_001091 Nc1sc2CCCCCc2c1C(=O)Nc3cccc(Cl)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B14 compound treatment 163760.0 52500.0 2.04 150760.0 51200.0 1.92 2.7993 0.9996 3083084 TimTec1_001092 CCCNC(=O)Cn1nc(cc1C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B15 compound treatment 117760.0 6540.0 0.25 138840.0 39200.0 1.47 1.2209 0.8168 3209740 TimTec1_001093 Cc1cc(Br)c(NC(=O)C2C(C)(C)C2(C)C)c(Br)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B16 compound treatment 100880.0 -10300.0 -0.4 96600.0 -2990.0 -0.11 -0.3632 -0.8714 1410434 TimTec1_001094 CC(C)(C)c1nc2ccccc2c(=O)n1c3ccc(F)cc3F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B17 compound treatment 73560.0 -37700.0 -1.46 73360.0 -26200.0 -0.98 -1.7295 -0.9815 3083156 TimTec1_001095 CCOC(=O)c1ccc(/N=C/c2ccc(CC)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B18 compound treatment 142520.0 31300.0 1.21 128160.0 28600.0 1.07 1.6168 0.9981 1578203 TimTec1_001096 Fc1ccc(NC(=O)CCC(=O)N(Cc2ccccc2)Cc3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B19 compound treatment 159440.0 48200.0 1.87 134320.0 34700.0 1.3 2.2445 0.9844 3083160 TimTec1_001097 CC(=O)Nc1nonc1/N=C\c2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B20 compound treatment 146880.0 35700.0 1.38 140960.0 41400.0 1.55 2.0761 0.9983 1344731 TimTec1_001098 Fc1ccc(CNC(=O)c2ccccc2C(=O)Cc3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B21 compound treatment 170240.0 59000.0 2.29 152440.0 52800.0 1.98 3.0217 0.9974 1376655 TimTec1_001099 COc1cc(SC)ccc1C(=O)NC2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B22 compound treatment 99280.0 -11900.0 -0.46 88000.0 -11600.0 -0.44 -0.6353 -0.9995 3209741 TimTec1_001100 Oc1ccc(cc1)C(=O)N2Cc3ccccc3N=C2S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B23 mock treatment 152320.0 41100.0 1.59 147920.0 48300.0 1.81 2.4101 0.9979 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 B24 mock treatment 135800.0 24600.0 0.95 118720.0 19100.0 0.72 1.1819 0.9902 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C01 compound treatment 51640.0 -59600.0 -2.31 43040.0 -56600.0 -2.12 -3.1356 -0.9991 3209742 TimTec1_001101 Cc1cccc(NC(=O)CSc2nsc(SCC(=O)Nc3cccc(C)c3)c2C#N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C02 compound treatment 8200.0 -103000.0 -4.0 7240.0 -92400.0 -3.47 -5.2775 -0.9975 3083163 TimTec1_001102 CCN(CC)c1cc(nc(SCC(=O)c2cccs2)c1C#N)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C03 compound treatment 109760.0 -1470.0 -0.06 90160.0 -9430.0 -0.35 -0.2905 -0.8103 3083164 TimTec1_001103 N=c1sc2ccccc2n1C(=O)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C04 compound treatment 10160.0 -101000.0 -3.92 7120.0 -92500.0 -3.47 -5.2269 -0.9981 3209743 TimTec1_001104 COc1cccc(c1)[C@@H]2[C@H](N3C=Cc4ccccc4[C@@H]3C2(C#N)C#N)c5ccc(OC)c(F)c5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C05 compound treatment 118840.0 7620.0 0.3 92720.0 -6870.0 -0.26 0.0266 0.0678 1213390 TimTec1_001105 O=C(CSC1OC2C=CC=CC2=N1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C06 compound treatment 111880.0 655.0 0.03 90760.0 -8830.0 -0.33 -0.2164 -0.651 3209744 TimTec1_001106 CC1CC(=O)C2=C(O1)OC(=C(C#N)C2c3ccccc3C(F)(F)F)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C07 compound treatment 118960.0 7740.0 0.3 88680.0 -10900.0 -0.41 -0.0773 -0.1523 1713226 TimTec1_001107 COc1cc2ccc(=O)oc2c(OC3OC(CO)C(O)C(O)C3O)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C08 compound treatment 8640.0 -103000.0 -3.98 7560.0 -92000.0 -3.45 -5.2569 -0.9975 3083167 TimTec1_001108 Cc1ccc(CSc2nc(ccc2C#N)C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C09 compound treatment 105920.0 -5310.0 -0.21 76840.0 -22800.0 -0.85 -0.7493 -0.8531 3209745 TimTec1_001109 COc1cc(cc(OC)c1OC)c2c(C#N)c(SCC#N)nc(N)c2C(=O)OC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C10 compound treatment 115560.0 4340.0 0.17 83880.0 -15700.0 -0.59 -0.298 -0.486 3083169 TimTec1_001110 CCc1ccc(cc1)[C@@H]2[C@H]3CN(CC=C3C(C#N)(C#N)C(=C2C#N)N)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C11 compound treatment 9600.0 -102000.0 -3.94 7320.0 -92300.0 -3.46 -5.2369 -0.9979 3209746 TimTec1_001111 Fc1cccc(CSC(=C(C#N)C#N)Nc2ccccc2Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C12 compound treatment 103080.0 -8150.0 -0.32 86040.0 -13600.0 -0.51 -0.5831 -0.9738 3209747 TimTec1_001112 COC(=O)C1=C(N)OC2=C(C1c3ccc(cc3)C(=O)OC)C(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C13 compound treatment 7600.0 -104000.0 -4.02 6120.0 -93500.0 -3.51 -5.3237 -0.9977 1123898 TimTec1_001113 COC(=O)[C@@]1(C#N)C([C@@H](C#N)N2[C@@H]1C=Cc3ccccc23)c4cc(OC)cc(OC)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C14 compound treatment 97000.0 -14200.0 -0.55 84560.0 -15000.0 -0.56 -0.7892 -0.9999 1317642 TimTec1_001114 COc1ccc(cc1)c2cc(SCCN3CCOCC3)c(C#N)c(n2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C15 compound treatment 16600.0 -94600.0 -3.67 13480.0 -86100.0 -3.23 -4.8814 -0.998 3083174 TimTec1_001115 CCOC(=O)C1=C(N)SC(=C(C#N)C1c2ccco2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C16 compound treatment 26360.0 -84900.0 -3.29 20880.0 -78700.0 -2.95 -4.4173 -0.9985 1197248 TimTec1_001116 Cc1cc2CC(=C(C#N)C(c3cccc(COc4ccccc4Cl)c3)c2c(=O)o1)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C17 compound treatment 8400.0 -103000.0 -3.99 7680.0 -91900.0 -3.45 -5.2603 -0.9974 3209748 TimTec1_001117 CCOC(=O)C1=C(OC(=C(C#N)C1c2ccc(cc2)c3ccccc3)N)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C18 compound treatment 124440.0 13200.0 0.51 105240.0 5650.0 0.21 0.5125 0.9236 3083176 TimTec1_001118 CC1CCN(CC1)C(=O)c2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C19 compound treatment 10440.0 -101000.0 -3.91 8520.0 -91100.0 -3.42 -5.1821 -0.9978 3209749 TimTec1_001119 CC1=C(C#N)C(C2=C(CC(CC2=O)c3ccc(Br)cc3)O1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C20 compound treatment 132760.0 21500.0 0.84 125720.0 26100.0 0.98 1.2843 0.9968 3083178 TimTec1_001120 CC(=O)NC(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C21 compound treatment 96880.0 -14300.0 -0.56 85480.0 -14100.0 -0.53 -0.7681 -0.9997 3209750 TimTec1_001121 COc1ccc(cc1OC)C(=O)COC2=C(C#N)C3(CCCC3)C(C#N)C(=S)N2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C22 compound treatment 96120.0 -15100.0 -0.59 79840.0 -19800.0 -0.74 -0.9386 -0.9932 3083180 TimTec1_001122 C1CCc2c(C1)sc3ncnc(Sc4ccccc4)c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C23 mock treatment 121360.0 10100.0 0.39 119240.0 19600.0 0.74 0.7995 0.9567 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 C24 mock treatment 138760.0 27500.0 1.07 110800.0 11200.0 0.42 1.0529 0.917 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D01 compound treatment 117320.0 6100.0 0.24 113280.0 13700.0 0.51 0.5305 0.938 1699716 TimTec1_001123 CCc1nc2sc(C)c(C)c2c(=O)n1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D02 compound treatment 127880.0 16700.0 0.65 117760.0 18200.0 0.68 0.9391 0.9996 3209751 TimTec1_001124 CC1(C)C(C(=O)NN2C(=O)c3ccccc3C2=O)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D03 compound treatment 121960.0 10700.0 0.42 108840.0 9250.0 0.35 0.54 0.9959 3082090 TimTec1_001125 CC(C)(C)NC(=O)CSc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D04 compound treatment 115040.0 3820.0 0.15 123240.0 23600.0 0.89 0.7323 0.8138 1162107 TimTec1_001126 CC(C)N1CCC2(CC1)C(=C(O)NC3=C2C(=O)CC(C)(C)C3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D05 compound treatment 136080.0 24900.0 0.96 125240.0 25600.0 0.96 1.3626 1.0 3209752 TimTec1_001127 COc1ccc(cc1)N2Cc3ccccc3C4(CCOCC4)C2=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D06 compound treatment 90280.0 -20900.0 -0.81 83720.0 -15900.0 -0.6 -0.9958 -0.9883 3209753 TimTec1_001128 COc1ccc(/N=C(\C)/c2c([nH]n(c3nc4ccccc4s3)c2=O)C(F)(F)F)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D07 compound treatment 125560.0 14300.0 0.56 113360.0 13800.0 0.52 0.7587 0.9993 1727579 TimTec1_001129 Clc1c(NCC2CCCO2)cnn(Cc3ccccc3)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D08 compound treatment 81440.0 -29800.0 -1.16 84080.0 -15500.0 -0.58 -1.2288 -0.9496 3082095 TimTec1_001130 Cc1ccc(cc1)C2=NNC(=S)C3=CNc4ccccc4N23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D09 compound treatment 10480.0 -101000.0 -3.91 8560.0 -91000.0 -3.42 -5.1799 -0.9977 1199669 TimTec1_001131 CCOc1ccc(NC(=O)c2c(N)sc3CCCc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D10 compound treatment 130880.0 19700.0 0.76 108960.0 9370.0 0.35 0.7879 0.9382 1714748 TimTec1_001132 NC(=O)CSc1nc2CC3=C(CCC3)c2c(=O)n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D11 compound treatment 121600.0 10400.0 0.4 104800.0 5210.0 0.2 0.4229 0.945 1348333 TimTec1_001133 O=c1oc(nc2ccccc12)c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D12 compound treatment 36280.0 -74900.0 -2.91 29200.0 -70400.0 -2.64 -3.9243 -0.9989 1118692 TimTec1_001134 O=C(N1CCCc2ccccc12)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D13 compound treatment 75480.0 -35700.0 -1.39 72040.0 -27600.0 -1.03 -1.7119 -0.9895 1352264 TimTec1_001135 CN(C)C(=O)c1c(NC(=O)c2ccc(C)cc2)sc3CCCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D14 compound treatment 93080.0 -18100.0 -0.7 87360.0 -12200.0 -0.46 -0.8224 -0.9785 3209754 TimTec1_001136 CCc1c(C)sc(NC(=O)/C=C/c2ccc(F)cc2)c1C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D15 compound treatment 104200.0 -7030.0 -0.27 99920.0 329.0 0.01 -0.184 -0.6744 3082099 TimTec1_001137 C=CC[n+]1ccc2ccccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D16 compound treatment 108640.0 -2590.0 -0.1 102080.0 2490.0 0.09 -0.0049 -0.0355 3209755 TimTec1_001138 FC(F)(F)c1cccc(c1)C(=O)Oc2ccc(cc2)C3SCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D17 compound treatment 108000.0 -3230.0 -0.13 101000.0 1410.0 0.05 -0.0511 -0.3761 3082101 TimTec1_001139 CCOc1ccc2ccccc2c1/C=N/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D18 compound treatment 10120.0 -101000.0 -3.92 8920.0 -90700.0 -3.4 -5.1802 -0.9975 1260565 TimTec1_001140 Clc1ccc(NC(=O)CN2CCCc3ccccc23)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D19 compound treatment 141400.0 30200.0 1.17 135880.0 36300.0 1.36 1.791 0.9972 1408681 TimTec1_001141 NNC(=O)c1cccc(Cn2cccn2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D20 compound treatment 115560.0 4340.0 0.17 101280.0 1690.0 0.06 0.1638 0.9111 3209756 TimTec1_001142 CC(C)Cn1c(=O)c2ccccc2[nH]c1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D21 compound treatment 130160.0 18900.0 0.73 115160.0 15600.0 0.58 0.9327 0.9936 1521586 TimTec1_001143 Cc1ccccc1OCc2nnc(SCC(=O)N)n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D22 compound treatment 122080.0 10900.0 0.42 104720.0 5130.0 0.19 0.4339 0.9371 3209757 TimTec1_001144 COc1ccc(/C=N/C2=NNC(=O)C(CC(=O)O)S2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D23 mock treatment 109840.0 -1390.0 -0.05 113280.0 13700.0 0.51 0.3253 0.6297 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 D24 mock treatment 125560.0 14300.0 0.56 104320.0 4730.0 0.18 0.5188 0.8886 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E01 compound treatment 117880.0 6660.0 0.26 100520.0 929.0 0.03 0.2072 0.7954 1632993 TimTec1_001145 NC(=O)c1cnn2c(N)c(C#N)cnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E02 compound treatment 65240.0 -46000.0 -1.78 74440.0 -25200.0 -0.94 -1.9291 -0.9557 1454243 TimTec1_001146 CC(C)OC(=O)C1=C(C)SC(=C(C#N)C1c2ccc(cc2)C(C)C)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E03 compound treatment 19480.0 -91700.0 -3.56 29400.0 -70200.0 -2.63 -4.3799 -0.989 3082105 TimTec1_001147 COc1cc(/C=N\C2=NN(CC2)c3ccccc3)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E04 compound treatment 9000.0 -102000.0 -3.97 8160.0 -91400.0 -3.43 -5.2311 -0.9974 3209876 TimTec1_001148 C[C@@H]1[C@H](N2C=Cc3ccccc3[C@@H]2C1(C#N)C#N)c4ccc(F)c(Br)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E05 compound treatment 70800.0 -40400.0 -1.57 69040.0 -30600.0 -1.15 -1.9199 -0.9881 1448274 TimTec1_001149 Cc1ccc2cccc(SC(=O)NCC3CCCO3)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E06 compound treatment 109040.0 -2190.0 -0.08 91480.0 -8110.0 -0.3 -0.2752 -0.8709 3082108 TimTec1_001150 NC1=C(C#N)C(C2=C(O1)C(=O)CCC2)c3ccccc3C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E07 compound treatment 127000.0 15800.0 0.61 93280.0 -6310.0 -0.24 0.2653 0.4043 1046360 TimTec1_001151 CC(=O)OCC1OC(C(OC(=O)C)C1OC(=O)C)n2ccc(=O)[nH]c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E08 compound treatment 9000.0 -102000.0 -3.97 7720.0 -91900.0 -3.45 -5.2428 -0.9976 1129068 TimTec1_001152 CN1CCc2c(nc(OCc3ccccc3Br)c(C#N)c2C1)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E09 compound treatment 98160.0 -13100.0 -0.51 69720.0 -29900.0 -1.12 -1.1512 -0.9356 3082110 TimTec1_001153 CSc1nc(SCC(=O)c2ccc3OCOc3c2)nc(N)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E10 compound treatment 44160.0 -67100.0 -2.6 33120.0 -66500.0 -2.49 -3.6041 -0.9998 1730487 TimTec1_001154 Cc1nc(C(=O)N)c(NCC=C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E11 compound treatment 108640.0 -2590.0 -0.1 86120.0 -13500.0 -0.51 -0.4284 -0.8312 1334043 TimTec1_001155 COc1cc2CCN(Cc2cc1OC)C(=O)Cn3c(C)cc(C)c(C#N)c3=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E12 compound treatment 6960.0 -104000.0 -4.05 6040.0 -93600.0 -3.51 -5.3434 -0.9975 1513685 TimTec1_001156 O=C(c1ccccc1)[C@@]2(C[C@@H](C#N)N3[C@@H]2C=Cc4ccccc34)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E13 compound treatment 6760.0 -104000.0 -4.05 6800.0 -92800.0 -3.48 -5.3287 -0.9971 1696559 TimTec1_001157 CCN(CC)c1c(C#N)c(SCC(=O)c2cccs2)cc3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E14 compound treatment 7520.0 -104000.0 -4.02 6520.0 -93100.0 -3.49 -5.3152 -0.9975 3209877 TimTec1_001158 CCOC(=O)N1CC=C2C(C1)C(C(=C(N)C2(C#N)C#N)C#N)c3cccc(c3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E15 compound treatment 7160.0 -104000.0 -4.04 6640.0 -93000.0 -3.49 -5.3219 -0.9973 1628055 TimTec1_001159 OC(=O)c1ccc(cc1)c2cc(c3cccs3)c(C#N)c(SCc4cccs4)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E16 compound treatment 26120.0 -85100.0 -3.3 43080.0 -56500.0 -2.12 -3.8347 -0.9771 1516512 TimTec1_001160 CC1=C(C(C(=C(S)S1)C#N)c2ccc[nH]2)C(=O)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E17 compound treatment 76760.0 -34500.0 -1.34 72520.0 -27100.0 -1.02 -1.664 -0.9908 1382001 TimTec1_001161 COc1cc(OC)cc(c1)C2C(=C(N)Nc3oc(C)nc23)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E18 compound treatment 116000.0 4780.0 0.19 104840.0 5250.0 0.2 0.2703 0.9995 3082493 TimTec1_001162 CC(C)(C)c1ccc(cc1)C(=O)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E19 compound treatment 110320.0 -905.0 -0.04 100160.0 569.0 0.02 -0.0097 -0.2367 3082494 TimTec1_001163 FC(F)(F)c1cc(c2cccs2)c(C#N)c(S)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E20 compound treatment 123120.0 11900.0 0.46 104080.0 4490.0 0.17 0.4455 0.9067 3209878 TimTec1_001164 CC1(C)C(C(=O)Nc2ccccc2C(F)(F)F)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E21 compound treatment 25960.0 -85300.0 -3.31 23360.0 -76200.0 -2.86 -4.3624 -0.9974 3209879 TimTec1_001165 CC(C)N1C/C(=C\c2ccccc2)/C(=O)\C(=C/c3ccccc3)\C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E22 compound treatment 8360.0 -103000.0 -3.99 7560.0 -92000.0 -3.45 -5.2646 -0.9974 1473801 TimTec1_001166 CCOC(=O)c1c(N)sc2c(OCC)c(Br)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E23 mock treatment 115160.0 3940.0 0.15 99960.0 369.0 0.01 0.1178 0.7681 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 E24 mock treatment 123560.0 12300.0 0.48 102600.0 3010.0 0.11 0.4183 0.8506 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F01 compound treatment 123400.0 12200.0 0.47 125800.0 26200.0 0.98 1.0296 0.9435 1148234 TimTec1_001167 Cc1sc(NC(=O)c2ccccc2)c(C(=O)N3CCCCC3)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F02 compound treatment 115560.0 4340.0 0.17 98880.0 -711.0 -0.03 0.1001 0.5876 3082495 TimTec1_001168 NCc1c[nH]nc1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F03 compound treatment 22040.0 -89200.0 -3.46 22320.0 -77300.0 -2.9 -4.4976 -0.9961 3082496 TimTec1_001169 CCCCC(=O)c1ccc(C)[nH]c1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F04 compound treatment 134440.0 23200.0 0.9 146880.0 47300.0 1.77 1.8919 0.9506 3209880 TimTec1_001170 FC(F)(F)c1cc([nH]c(=S)c1C#N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F05 compound treatment 141160.0 29900.0 1.16 127480.0 27900.0 1.05 1.5614 0.9987 1552345 TimTec1_001171 OC1CS(=O)(=O)CC1NCc2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F06 compound treatment 138280.0 27100.0 1.05 127760.0 28200.0 1.06 1.4899 1.0 3209881 TimTec1_001172 Cn1ncc(Br)c1c2nc3ccccc3[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F07 compound treatment 108600.0 -2630.0 -0.1 96160.0 -3430.0 -0.13 -0.1631 -0.9933 1231705 TimTec1_001173 Clc1c(NCCc2ccccc2)cnn(c3ccccc3)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F08 compound treatment 63080.0 -48100.0 -1.87 72480.0 -27100.0 -1.02 -2.0404 -0.9592 3082497 TimTec1_001174 COc1ccc(cc1)C2=NNC(=S)C3=CNc4ccccc4N23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F09 compound treatment 99920.0 -11300.0 -0.44 98920.0 -671.0 -0.03 -0.328 -0.7465 1268647 TimTec1_001175 O=C(Nc1ccccc1)c2c(NC(=O)c3ccccc3)sc4CCCCc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F10 compound treatment 95920.0 -15300.0 -0.59 94120.0 -5470.0 -0.21 -0.5651 -0.8994 1547144 TimTec1_001176 CC(NC(=O)CSc1nc2CC3=C(CCCC3)c2c(=O)n1C)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F11 compound treatment 10600.0 -101000.0 -3.9 9080.0 -90500.0 -3.4 -5.1628 -0.9976 1204419 TimTec1_001177 CC1CCc2c(C(=O)Nc3ccc(Cl)cc3)c(N)sc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F12 compound treatment 94400.0 -16800.0 -0.65 97440.0 -2150.0 -0.08 -0.5187 -0.7885 1256297 TimTec1_001178 C(Cc1ccco1)C2NCCn3cccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F13 compound treatment 55280.0 -55900.0 -2.17 64400.0 -35200.0 -1.32 -2.4688 -0.9716 1201070 TimTec1_001179 CCOC(=O)c1c(NC(=O)C)sc2CCCCCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F14 compound treatment 81160.0 -30100.0 -1.17 68720.0 -30900.0 -1.16 -1.6441 -1.0 1590373 TimTec1_001180 CC(NC(=O)CC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F15 compound treatment 123480.0 12300.0 0.48 115040.0 15400.0 0.58 0.7462 0.9951 1021946 TimTec1_001181 OC(=O)C1CCCN1C(=O)OCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F16 compound treatment 112000.0 775.0 0.03 110640.0 11000.0 0.41 0.3145 0.7564 3209882 TimTec1_001182 CCOc1ccc(cc1)N2C(=O)CCC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F17 compound treatment 90240.0 -21000.0 -0.81 58440.0 -41200.0 -1.54 -1.6678 -0.9553 3209883 TimTec1_001183 CCn1c2C(=O)CCCc2c3cc(Br)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F18 compound treatment 123040.0 11800.0 0.46 104960.0 5370.0 0.2 0.4666 0.9319 1674582 TimTec1_001184 OCCN(CC(=O)Nc1ccc(F)cc1)C(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F19 compound treatment 89440.0 -21800.0 -0.85 103680.0 4090.0 0.15 -0.4892 -0.5694 1384058 TimTec1_001185 Cc1ccc2oc3nc(N)c(cc3c(=O)c2c1)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F20 compound treatment 126840.0 15600.0 0.61 127360.0 27800.0 1.04 1.1654 0.9667 1143739 TimTec1_001186 CC(C)Cn1c(SCC(=O)Nc2ccc(F)cc2F)nc3ccccc3c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F21 compound treatment 123480.0 12300.0 0.48 105560.0 5970.0 0.22 0.4946 0.941 1602491 TimTec1_001187 COC(=O)c1ccc(NC(=O)CSC(=S)N2CCOCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F22 compound treatment 115680.0 4460.0 0.17 109160.0 9570.0 0.36 0.3762 0.9438 3082498 TimTec1_001188 Brc1ccc(cc1)C(=O)CN2CCCC2=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F23 mock treatment 113440.0 2220.0 0.09 104960.0 5370.0 0.2 0.2033 0.9278 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 F24 mock treatment 131840.0 20600.0 0.8 105920.0 6330.0 0.24 0.7336 0.8792 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G01 compound treatment 102880.0 -8350.0 -0.32 88600.0 -11000.0 -0.41 -0.5206 -0.9928 1278450 TimTec1_001189 CCOC(=O)c1cnn2c(N)c(C#N)cnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G02 compound treatment 8480.0 -103000.0 -3.99 6480.0 -93100.0 -3.49 -5.29 -0.9978 1287956 TimTec1_001190 NC1=C(C#N)C(c2ccccc2Cl)c3c(S1)oc(cc3=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G03 compound treatment 71480.0 -39700.0 -1.54 76960.0 -22600.0 -0.85 -1.691 -0.9605 1053983 TimTec1_001191 COC(=O)C1CNc2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G04 compound treatment 35800.0 -75400.0 -2.93 33520.0 -66100.0 -2.48 -3.8228 -0.9966 3082499 TimTec1_001192 COC(=O)C1=C(N)OC(=C(C#N)C1c2ccncc2)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G05 compound treatment 95280.0 -15900.0 -0.62 87200.0 -12400.0 -0.47 -0.7663 -0.9901 3209884 TimTec1_001193 CC1=CC(C)(C)CC(=S)N1c2cccc(F)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G06 compound treatment 8880.0 -102000.0 -3.97 7840.0 -91800.0 -3.44 -5.2429 -0.9975 3082500 TimTec1_001194 NC1=C(C#N)C(=C(C#N)C(S1)c2cccs2)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G07 compound treatment 44560.0 -66700.0 -2.59 33000.0 -66600.0 -2.5 -3.5963 -0.9999 3209885 TimTec1_001195 O=C1CNC(=S)N1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G08 compound treatment 63440.0 -47800.0 -1.85 65040.0 -34600.0 -1.3 -2.228 -0.9847 1277858 TimTec1_001196 Cc1c2cc(sc2nc3c(O)cc(=O)[nH]c13)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G09 compound treatment 107880.0 -3350.0 -0.13 87720.0 -11900.0 -0.45 -0.4068 -0.8767 1296353 TimTec1_001197 CCOC(=O)c1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G10 compound treatment 56880.0 -54300.0 -2.11 52000.0 -47600.0 -1.79 -2.754 -0.9966 3209886 TimTec1_001198 OC(=O)c1c(SC(C#N)c2ccc(Cl)cc2)nc(cc1c3ccccc3)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G11 compound treatment 31120.0 -80100.0 -3.11 32920.0 -66700.0 -2.5 -3.9671 -0.9942 1298662 TimTec1_001199 COC(=O)C1=C(C)NC(=C(C#N)C1c2ccc3OCCOc3c2)SCC(=O)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G12 compound treatment 94560.0 -16700.0 -0.65 80840.0 -18800.0 -0.7 -0.9549 -0.9991 1652210 TimTec1_001200 COC(=O)C1=C(N)OC(=C(C1c2ccc(OC)c(OC)c2)C(=O)OC)CC#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G13 compound treatment 12680.0 -98500.0 -3.82 26000.0 -73600.0 -2.76 -4.6567 -0.9873 1672888 TimTec1_001201 Oc1cc(=O)c2sc3nc(c4cccnc4)c5CCCCc5c3c2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G14 compound treatment 50800.0 -60400.0 -2.34 55240.0 -44400.0 -1.66 -2.8348 -0.9859 1564023 TimTec1_001202 CC(C)c1ccc(cc1)C2C3CN(C)CC=C3C(C#N)(C#N)C(=C2C#N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G15 compound treatment 92600.0 -18600.0 -0.72 95200.0 -4390.0 -0.16 -0.6275 -0.8466 3210009 TimTec1_001203 COC(=O)C1=CN2[C@@H](C#N)[C@H](c3cccnc3)C(C2C=C1)(C(=O)OC)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G16 compound treatment 39240.0 -72000.0 -2.79 45720.0 -53900.0 -2.02 -3.4047 -0.9874 1397215 TimTec1_001204 CCNC(=O)c1sc(C)nc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G17 compound treatment 44240.0 -67000.0 -2.6 50160.0 -49400.0 -1.86 -3.1496 -0.9863 3082503 TimTec1_001205 CSc1nc(SCC(=O)C(C)C)nc(N)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G18 compound treatment 106040.0 -5190.0 -0.2 96600.0 -2990.0 -0.11 -0.2216 -0.962 1115621 TimTec1_001206 CC(=O)Nc1nc2ccccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G19 compound treatment 48040.0 -63200.0 -2.45 46400.0 -53200.0 -2.0 -3.1452 -0.9948 3210010 TimTec1_001207 NC1=C(C#N)C(c2ccc(Br)cc2)c3c(N1)c4ccccc4oc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G20 compound treatment 104720.0 -6510.0 -0.25 93560.0 -6030.0 -0.23 -0.3385 -0.9985 1129886 TimTec1_001208 CC1(C)C(C(=O)Nc2ccccc2C#N)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G21 compound treatment 116120.0 4900.0 0.19 103040.0 3450.0 0.13 0.2258 0.9825 1646804 TimTec1_001209 CC1=CC(=C(C#N)C(=S)C1CC(=O)c2cccs2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G22 compound treatment 66480.0 -44700.0 -1.74 61080.0 -38500.0 -1.45 -2.2497 -0.9959 1362352 TimTec1_001210 Cc1ccc(cc1)S(=O)(=O)N(CCO)c2cc3CCCCc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G23 mock treatment 109840.0 -1390.0 -0.05 104120.0 4530.0 0.17 0.0822 0.4611 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 G24 mock treatment 121240.0 10000.0 0.39 98680.0 -911.0 -0.03 0.2506 0.6424 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H01 compound treatment 5160.0 -106000.0 -4.12 4120.0 -95500.0 -3.58 -5.4437 -0.9976 1120313 TimTec1_001211 Cn1c2C(=O)CCCCc2c3cc(ccc13)C4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H02 compound treatment 5920.0 -105000.0 -4.09 4840.0 -94800.0 -3.56 -5.4037 -0.9976 3082508 TimTec1_001212 CC/1=NN(C(=O)\C1=C/c2c[nH]nc2c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H03 compound treatment 104920.0 -6310.0 -0.24 105800.0 6210.0 0.23 -0.0082 -0.0243 1013623 TimTec1_001213 NC(=O)c1nnn(Cc2ccccc2)c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H04 compound treatment 120320.0 9100.0 0.35 118960.0 19400.0 0.73 0.7636 0.9449 3210011 TimTec1_001214 FC(F)(F)c1cc(oc(=S)c1C#N)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H05 compound treatment 7960.0 -103000.0 -4.01 7040.0 -92600.0 -3.47 -5.2894 -0.9975 1733044 TimTec1_001215 NC(=O)c1ccc(nc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H06 compound treatment 123440.0 12200.0 0.47 114960.0 15400.0 0.58 0.743 0.9952 1733896 TimTec1_001216 O=C(NCCC(c1ccccc1)c2ccccc2)c3cc4ccccc4c(=O)o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H07 compound treatment 208560.0 97300.0 3.78 106760.0 7170.0 0.27 2.8607 0.7556 1785401 TimTec1_001217 Clc1c(NCC2CCCO2)cn[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H08 compound treatment 65720.0 -45500.0 -1.77 51400.0 -48200.0 -1.81 -2.5274 -0.9999 3210012 TimTec1_001218 Cc1cc(C)c(C(=O)N2Cc3ccccc3N=C2S)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H09 compound treatment 110160.0 -1070.0 -0.04 111080.0 11500.0 0.43 0.2757 0.6364 1181388 TimTec1_001219 O=C(Nc1ccccc1)C(=C2CCCC2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H10 compound treatment 9800.0 -101000.0 -3.94 22480.0 -77100.0 -2.89 -4.8291 -0.9886 1174029 TimTec1_001220 C(N1CCN(Cc2ccccc2)C1c3ccco3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H11 compound treatment 106680.0 -4550.0 -0.18 105560.0 5970.0 0.22 0.0337 0.1183 1687568 TimTec1_001221 O=C(Nc1ccccc1C(=O)Nc2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H12 compound treatment 62200.0 -49000.0 -1.9 65680.0 -33900.0 -1.27 -2.245 -0.9809 1393827 TimTec1_001222 CCc1ccc(cc1)C(=O)CC2OC(=O)c3c2ccc(OC)c3OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H13 compound treatment 115960.0 4740.0 0.18 121760.0 22200.0 0.83 0.7183 0.8429 1145002 TimTec1_001223 CCC(=O)Nc1sc2CCCCCc2c1C(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H14 compound treatment 6880.0 -104000.0 -4.05 7000.0 -92600.0 -3.48 -5.3201 -0.9971 3210013 TimTec1_001224 Clc1ccc(SC2CC(=O)N(C2=O)c3ccc(Br)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H15 compound treatment 107800.0 -3430.0 -0.13 99920.0 329.0 0.01 -0.0852 -0.6386 1022241 TimTec1_001225 O=C1CCN(N1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H16 compound treatment 108480.0 -2750.0 -0.11 118160.0 18600.0 0.7 0.4175 0.5922 3082550 TimTec1_001226 CC(C)(C)c1ccc(cc1)N2C(=O)CCC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H17 compound treatment 87040.0 -24200.0 -0.94 82120.0 -17500.0 -0.66 -1.1272 -0.9846 3210014 TimTec1_001227 N/N=C/1\CCCc2c1[nH]c3ccc(cc23)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H18 compound treatment 9760.0 -101000.0 -3.94 11720.0 -87900.0 -3.3 -5.1158 -0.9961 1154220 TimTec1_001228 Cc1n[nH]c2oc(=O)c(Cc3cccc(C)c3)c(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H19 compound treatment 116200.0 4980.0 0.19 102280.0 2690.0 0.1 0.2079 0.9543 1503917 TimTec1_001229 Clc1ccc(cc1)C(=O)c2oc3ccccc3c2c4cnn(c4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H20 compound treatment 82520.0 -28700.0 -1.11 55360.0 -44200.0 -1.66 -1.9614 -0.9812 1445779 TimTec1_001230 Fc1ccc(CSc2nc3ccccc3c(=O)n2c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H21 compound treatment 101960.0 -9270.0 -0.36 102800.0 3210.0 0.12 -0.169 -0.4458 1530713 TimTec1_001231 O=C(NCCc1ccc(cc1)S(=O)(=O)N2CCCC2)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H22 compound treatment 51080.0 -60100.0 -2.33 72000.0 -27600.0 -1.04 -2.3824 -0.9331 3082554 TimTec1_001232 FC(F)(F)C1=Nc2ccccc2N(C1)c3ccc(Cl)c(Cl)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H23 mock treatment 122600.0 11400.0 0.44 114160.0 14600.0 0.55 0.6987 0.9944 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 H24 mock treatment 105920.0 -5310.0 -0.21 95920.0 -3670.0 -0.14 -0.243 -0.9809 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I01 compound treatment 76960.0 -34300.0 -1.33 68680.0 -30900.0 -1.16 -1.7604 -0.9977 1641212 TimTec1_001233 Cc1cc(C)c(C#N)c(SCC(=O)N2CCCCC2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I02 compound treatment 4560.0 -107000.0 -4.14 4240.0 -95400.0 -3.58 -5.457 -0.9974 1202800 TimTec1_001234 CC1=C(C#N)C(C(=C(N)O1)C(=O)OCc2ccccc2)c3cc(F)ccc3F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I03 compound treatment 70120.0 -41100.0 -1.59 51160.0 -48400.0 -1.82 -2.4131 -0.9979 1249954 TimTec1_001235 CC(C)c1ccc(C)cc1OCc2ccc(N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I04 compound treatment 65440.0 -45800.0 -1.78 48920.0 -50700.0 -1.9 -2.6009 -0.9994 3210015 TimTec1_001236 COc1cc(OCCN2CCOCC2)ccc1C3C(=C(N)Oc4[nH]c(nc34)C(F)(F)F)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I05 compound treatment 70320.0 -40900.0 -1.59 61880.0 -37700.0 -1.42 -2.1231 -0.9984 3082557 TimTec1_001237 CC(C)c1ccc(cc1)N2C(=CC(C)(C)NC2=S)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I06 compound treatment 43240.0 -68000.0 -2.64 42200.0 -57400.0 -2.15 -3.3883 -0.9949 1171191 TimTec1_001238 CCCc1n[nH]c2N(C(=C(C#N)C(c3c(C)onc3Cl)c12)N)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I07 compound treatment 95840.0 -15400.0 -0.6 77640.0 -22000.0 -0.82 -1.0047 -0.9875 1003607 TimTec1_001239 OC(=O)c1cc(nc2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I08 compound treatment 99080.0 -12100.0 -0.47 68560.0 -31000.0 -1.16 -1.1567 -0.9207 1696034 TimTec1_001240 CC(C)OC(=O)c1cc(N)c2c(c(sc2n1)c3cccs3)c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I09 compound treatment 90400.0 -20800.0 -0.81 77480.0 -22100.0 -0.83 -1.1582 -0.9999 3082561 TimTec1_001241 NC(=O)COc1ccc(cc1)C2C(=C(N)Oc3[nH]c(nc23)c4ccccc4)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I10 compound treatment 63640.0 -47600.0 -1.85 63880.0 -35700.0 -1.34 -2.2533 -0.9876 1275672 TimTec1_001242 CC(C)(C)c1cc(c2cccs2)c(C#N)c(SCC(=O)Oc3ccccc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I11 compound treatment 10720.0 -101000.0 -3.9 10400.0 -89200.0 -3.35 -5.1245 -0.9971 1564906 TimTec1_001243 COCc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccccc3COc4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I12 compound treatment 103120.0 -8110.0 -0.31 91680.0 -7910.0 -0.3 -0.4323 -0.9996 1280361 TimTec1_001244 CC(C)(C)c1nc2C(C(=C(N)Nc2o1)C(=O)N)c3ccc(OCC#N)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I13 compound treatment 88120.0 -23100.0 -0.9 94280.0 -5310.0 -0.2 -0.7749 -0.8437 1705544 TimTec1_001245 CC(C)c1ccc(cc1)C2C(=C(N)Oc3[nH]c(C)nc23)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I14 compound treatment 6520.0 -105000.0 -4.06 6240.0 -93400.0 -3.5 -5.3501 -0.9973 1235982 TimTec1_001246 CC1=C(OC(=C(C#N)C1c2ccc(F)cc2)N)C(=O)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I15 compound treatment 100720.0 -10500.0 -0.41 97360.0 -2230.0 -0.08 -0.3474 -0.8349 1422848 TimTec1_001247 COC(=O)C1=C(C)Oc2oc(C)cc(=O)c2C1c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I16 compound treatment 101800.0 -9430.0 -0.37 76360.0 -23200.0 -0.87 -0.8751 -0.9256 1729172 TimTec1_001248 Nc1sc(NCC=C)c(C(=O)c2ccc(Br)s2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I17 compound treatment 85400.0 -25800.0 -1.0 76840.0 -22800.0 -0.85 -1.3123 -0.9968 1693885 TimTec1_001249 CCCc1nc2C(C(=C(N)Oc2o1)C#N)c3cccc(O)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I18 compound treatment 91680.0 -19500.0 -0.76 81480.0 -18100.0 -0.68 -1.0169 -0.9985 1371394 TimTec1_001250 Clc1ccccc1C(=O)NC(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I19 compound treatment 7840.0 -103000.0 -4.01 7560.0 -92000.0 -3.45 -5.2789 -0.9972 3210016 TimTec1_001251 CC1=C(C#N)C(C2=C(O1)C(=O)CCC2)c3ccccc3C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I20 compound treatment 100040.0 -11200.0 -0.43 86080.0 -13500.0 -0.51 -0.6654 -0.997 3082567 TimTec1_001252 CC1(C)C(C(=O)Nc2nccs2)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I21 compound treatment 15480.0 -95700.0 -3.71 18640.0 -81000.0 -3.04 -4.7752 -0.995 3210017 TimTec1_001253 COCCC(=O)C1=CSC2=C(C1c3ccncc3)C(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I22 compound treatment 130080.0 18900.0 0.73 102720.0 3130.0 0.12 0.6003 0.8102 3082601 TimTec1_001254 O=c1n2CCCc2nc3scc(c4ccccc4)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I23 mock treatment 111000.0 -225.0 -0.01 101400.0 1810.0 0.07 0.0418 0.6112 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 I24 mock treatment 103040.0 -8190.0 -0.32 91960.0 -7630.0 -0.29 -0.4271 -0.9987 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J01 compound treatment 101440.0 -9790.0 -0.38 115880.0 16300.0 0.61 0.1638 0.2277 1686618 TimTec1_001255 COC(=O)C1(CC2(CC3(CC(C1)(C(=O)OC)C2=O)C(=O)OC)C(=O)OC)C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J02 compound treatment 4680.0 -107000.0 -4.13 4520.0 -95100.0 -3.57 -5.4462 -0.9973 3210018 TimTec1_001256 CCOc1cc(/C=C\2/SC(=N)N(C2=O)c3nccs3)ccc1OCCN4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J03 compound treatment 96120.0 -15100.0 -0.59 95440.0 -4150.0 -0.16 -0.5246 -0.865 1190635 TimTec1_001257 CC1OC(NC(=O)c2ccccc2F)C(NC(=O)c3ccccc3F)OC1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J04 compound treatment 114480.0 3260.0 0.13 106800.0 7210.0 0.27 0.2806 0.9398 1013629 TimTec1_001258 OC(=O)c1cc(Cc2ccc(O)c(c2)C(=O)O)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J05 compound treatment 66680.0 -44500.0 -1.73 65040.0 -34600.0 -1.3 -2.1391 -0.99 3082606 TimTec1_001259 Clc1ccc(OCCCC(=O)Nc2ccc3OCCOc3c2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J06 compound treatment 71840.0 -39400.0 -1.53 41760.0 -57800.0 -2.17 -2.6153 -0.9853 3210135 TimTec1_001260 N/C(=N/C#N)/c1sc2nc3CCCCCc3cc2c1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J07 compound treatment 112880.0 1660.0 0.06 109480.0 9890.0 0.37 0.3079 0.8173 3082608 TimTec1_001261 CN(C)CCNc1cn[nH]c(=O)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J08 compound treatment 106280.0 -4950.0 -0.19 108800.0 9210.0 0.35 0.1087 0.275 3210136 TimTec1_001262 CS(=O)(=O)NCCOc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J09 compound treatment 116360.0 5140.0 0.2 99840.0 249.0 0.01 0.1475 0.7395 1582682 TimTec1_001263 OC(=O)c1ccccc1NC(=O)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J10 compound treatment 113360.0 2140.0 0.08 109560.0 9970.0 0.37 0.3231 0.8432 1203455 TimTec1_001264 Nc1ccc(cc1)C(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J11 compound treatment 111320.0 95.0 0.0 98640.0 -951.0 -0.04 -0.0226 -0.6307 1327302 TimTec1_001265 Cc1ccccc1NC(=O)c2ccccc2NC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J12 compound treatment 116560.0 5340.0 0.21 113280.0 13700.0 0.51 0.5097 0.9201 1350742 TimTec1_001266 OC(=O)c1cc(C(=O)O)c2cccc(Cl)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J13 compound treatment 7480.0 -104000.0 -4.03 7480.0 -92100.0 -3.46 -5.2909 -0.9971 1127240 TimTec1_001267 CNC(=O)c1c(N)sc2CCCCCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J14 compound treatment 6320.0 -105000.0 -4.07 5440.0 -94200.0 -3.53 -5.3768 -0.9975 3210137 TimTec1_001268 CC(C)(C)c1ccc(cc1)C(=O)CC(N2CCCCC2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J15 compound treatment 99800.0 -11400.0 -0.44 102760.0 3170.0 0.12 -0.2294 -0.4997 1913738 TimTec1_001269 Oc1ccc(/C=N/c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J16 compound treatment 98000.0 -13200.0 -0.51 90440.0 -9150.0 -0.34 -0.6057 -0.9809 1404011 TimTec1_001270 O=C(Cc1ccccc1)Oc2ccc(cc2)C3SCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J17 compound treatment 6720.0 -105000.0 -4.05 5960.0 -93600.0 -3.51 -5.3521 -0.9975 1230646 TimTec1_001271 C1CCC(CC1)c2ccc3c(c2)c4CCCc5nccn3c45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J18 compound treatment 44120.0 -67100.0 -2.6 37760.0 -61800.0 -2.32 -3.482 -0.9984 3210138 TimTec1_001272 Clc1ccc(CSC2CC(=O)N(C2=O)c3ccc(Br)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J19 compound treatment 113840.0 2620.0 0.1 98160.0 -1430.0 -0.05 0.0338 0.2942 1613380 TimTec1_001273 CN1C(=O)COc2ccc(cc12)C(=O)c3ccccc3C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J20 compound treatment 114720.0 3500.0 0.14 100040.0 449.0 0.02 0.1078 0.7889 1384728 TimTec1_001274 COc1ccc(NCC(C#N)C(=O)NCc2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J21 compound treatment 99160.0 -12100.0 -0.47 105000.0 5410.0 0.2 -0.1875 -0.3674 3210139 TimTec1_001275 COc1ccc(CCNC(=N)Nc2nc(C)cc(C)n2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J22 compound treatment 7800.0 -103000.0 -4.01 6920.0 -92700.0 -3.48 -5.2969 -0.9975 3082616 TimTec1_001276 SC1=Nc2ccccc2CN1C(=O)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J23 mock treatment 104080.0 -7150.0 -0.28 101280.0 1690.0 0.06 -0.1512 -0.5317 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 J24 mock treatment 120720.0 9500.0 0.37 86200.0 -13400.0 -0.5 -0.0949 -0.1523 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K01 compound treatment 72920.0 -38300.0 -1.49 69920.0 -29700.0 -1.11 -1.8384 -0.9899 3210140 TimTec1_001277 N=c1sc(C(=O)c2ccccc2)c3scc(c4ccccc4)n13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K02 compound treatment 4520.0 -107000.0 -4.14 4960.0 -94600.0 -3.55 -5.439 -0.9971 1261528 TimTec1_001278 COc1cc(OC)cc(c1)C2C(=C(N)OC(=C2C#N)N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K03 compound treatment 93320.0 -17900.0 -0.69 72400.0 -27200.0 -1.02 -1.2129 -0.9824 1566998 TimTec1_001279 COc1ccc(NC(=O)Nc2ccc(OC)c(OC)c2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K04 compound treatment 51280.0 -59900.0 -2.33 35920.0 -63700.0 -2.39 -3.3344 -0.9999 1394262 TimTec1_001280 COC(=O)[C@H]1[C@H](c2ccccc2)[C@@](C#N)([C@@H]3C=CC(=C(C)N13)C(=O)OC)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K05 compound treatment 101800.0 -9430.0 -0.37 79280.0 -20300.0 -0.76 -0.7976 -0.9434 1004876 TimTec1_001281 OC(=O)c1cc(=O)cc(o1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K06 compound treatment 86280.0 -24900.0 -0.97 75400.0 -24200.0 -0.91 -1.3264 -0.9995 3082619 TimTec1_001282 Cc1nc(/C=C(/N)\C#N)cn1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K07 compound treatment 95040.0 -16200.0 -0.63 81040.0 -18600.0 -0.7 -0.9364 -0.9987 1429878 TimTec1_001283 COc1ccc2CCC(CC3(O)C(=O)Nc4ccccc43)C(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K08 compound treatment 90480.0 -20700.0 -0.8 76640.0 -23000.0 -0.86 -1.1783 -0.9994 1203304 TimTec1_001284 Cc1sc2nc(cc(N)c2c1C)C(=O)Oc3ccc(F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K09 compound treatment 69920.0 -41300.0 -1.6 61840.0 -37800.0 -1.42 -2.1351 -0.9981 3210142 TimTec1_001285 NC(=S)/C(=C\Nc1ccccc1C#N)/C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K10 compound treatment 98240.0 -13000.0 -0.5 76680.0 -22900.0 -0.86 -0.9643 -0.9676 1195774 TimTec1_001286 CC(C)c1ccc(cc1)C2C(=C(Oc3[nH]c(C)nc23)C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K11 compound treatment 81080.0 -30100.0 -1.17 76240.0 -23400.0 -0.88 -1.4468 -0.9899 1673016 TimTec1_001287 COc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccc(OC(C)C)c(OC)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K12 compound treatment 90320.0 -20900.0 -0.81 76240.0 -23400.0 -0.88 -1.1933 -0.9993 1572307 TimTec1_001288 CCCN1CC=C2C(C#N)(C#N)C(=C(C#N)C(c3ccc(OCC(=O)N)cc3)C2(C)C1)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K13 compound treatment 59720.0 -51500.0 -2.0 44600.0 -55000.0 -2.06 -2.8725 -0.9999 1290293 TimTec1_001289 Cc1nc2c(OC(=C(C#N)C32CCC(CC3)c4ccccc4)N)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K14 compound treatment 47280.0 -63900.0 -2.48 42000.0 -57600.0 -2.16 -3.2828 -0.9976 1495492 TimTec1_001290 CC(C)N1CC=C2C(C1)C(C(=C(N)C2(C#N)C#N)C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K15 compound treatment 63000.0 -48200.0 -1.87 60680.0 -38900.0 -1.46 -2.3558 -0.9925 1213258 TimTec1_001291 CCOC(=O)C(C#N)C(c1[nH]c(C)nc1O)c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K16 compound treatment 53360.0 -57900.0 -2.25 33320.0 -66300.0 -2.49 -3.3463 -0.9987 1320005 TimTec1_001292 CCCc1cc(ccc1OC(C)C)C2C(=C(N)Nc3oc(OC)nc23)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K17 compound treatment 73920.0 -37300.0 -1.45 71080.0 -28500.0 -1.07 -1.7801 -0.989 1432035 TimTec1_001293 CC1(C)CC(=O)C2=C(C1)N(Cc3ccccc3)C(=C(C#N)C42CCOCC4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K18 compound treatment 68560.0 -42700.0 -1.66 52680.0 -46900.0 -1.76 -2.4155 -0.9995 1488829 TimTec1_001294 Clc1cccc(c1)C(=O)N(Cc2ccccc2)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K19 compound treatment 19440.0 -91800.0 -3.56 13640.0 -86000.0 -3.23 -4.7993 -0.9988 3210143 TimTec1_001295 Fc1ccc(cc1)C(=O)[C@@H]2[C@@H](C#N)[C@@](C#N)([C@@H]3N2C=Cc4ccccc34)C(=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K20 compound treatment 68960.0 -42300.0 -1.64 67280.0 -32300.0 -1.21 -2.0171 -0.989 1628961 TimTec1_001296 CC1(C)C(C(=O)Nc2ccc(cc2)S(=O)(=O)c3ccc(NC(=O)C4C(C)(C)C4(C)C)cc3)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K21 compound treatment 63080.0 -48100.0 -1.87 69560.0 -30000.0 -1.13 -2.1179 -0.9707 1142263 TimTec1_001297 COC(=O)C1=C(C)SC(=C(C#N)C1c2ccc(OC(C)C)c(OC)c2)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K22 compound treatment 82560.0 -28700.0 -1.11 75280.0 -24300.0 -0.91 -1.4316 -0.9952 1427516 TimTec1_001298 O=C(N1CN(Cc2c3CCCCc3sc12)C4CCCCC4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K23 mock treatment 111960.0 735.0 0.03 100040.0 449.0 0.02 0.0321 0.9685 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 K24 mock treatment 85800.0 -25400.0 -0.99 89040.0 -10600.0 -0.4 -0.9776 -0.9196 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L01 compound treatment 49600.0 -61600.0 -2.39 61800.0 -37800.0 -1.42 -2.6937 -0.9689 1725268 TimTec1_001299 CCc1cc2c(=O)c(coc2cc1OC(=O)C)c3ccn(n3)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L02 compound treatment 3800.0 -107000.0 -4.17 3280.0 -96300.0 -3.61 -5.5033 -0.9975 3082669 TimTec1_001300 N=C1S/C(=C/c2ccco2)/C(=O)N1c3nccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L03 compound treatment 100320.0 -10900.0 -0.42 97080.0 -2510.0 -0.09 -0.3658 -0.8439 1704974 TimTec1_001301 COC1C(OC)N(CCN1S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L04 compound treatment 6200.0 -105000.0 -4.07 4640.0 -95000.0 -3.56 -5.4014 -0.9978 1126229 TimTec1_001302 CC(C)(C)c1cc(O)cc(c1CN2CCN(CCN)CC2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L05 compound treatment 107400.0 -3830.0 -0.15 103680.0 4090.0 0.15 0.0036 0.0168 3210144 TimTec1_001303 O=C1CN2C(=C1c3nc4ccccc4c(=O)[nH]3)NC(=O)c5ccccc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L06 compound treatment 100200.0 -11000.0 -0.43 103280.0 3690.0 0.14 -0.2046 -0.455 1508923 TimTec1_001304 CN1CCC2(CC1)C(=C(N)Oc3n[nH]c(C(=O)OC(C)(C)C)c32)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L07 compound treatment 91840.0 -19400.0 -0.75 76960.0 -22600.0 -0.85 -1.1324 -0.9982 1206601 TimTec1_001305 O=c1[nH]nc(c2ccccc2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L08 compound treatment 109160.0 -2070.0 -0.08 90880.0 -8710.0 -0.33 -0.2878 -0.8551 3210145 TimTec1_001306 COC(=O)c1ccc2ccccc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L09 compound treatment 49400.0 -61800.0 -2.4 42280.0 -57300.0 -2.15 -3.2172 -0.9985 1306892 TimTec1_001307 OC(=O)c1c(NC(=O)c2ccc(Br)cc2)sc3CCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L10 compound treatment 103320.0 -7910.0 -0.31 105960.0 6370.0 0.24 -0.0479 -0.1231 1170047 TimTec1_001308 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L11 compound treatment 105400.0 -5830.0 -0.23 95400.0 -4190.0 -0.16 -0.271 -0.9843 1153508 TimTec1_001309 CCc1nc2ccccc2c(=O)n1c3ccc(OC)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L12 compound treatment 93560.0 -17700.0 -0.69 92800.0 -6790.0 -0.25 -0.6649 -0.9092 1500311 TimTec1_001310 OC(=O)c1cc(O)nc2c(Cl)cccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L13 compound treatment 14480.0 -96700.0 -3.75 11360.0 -88200.0 -3.31 -4.9958 -0.998 1714700 TimTec1_001311 CCOc1ccc(NC(=O)C(=C2CCCCCC2)C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L14 compound treatment 5960.0 -105000.0 -4.08 42720.0 -56900.0 -2.13 -4.3973 -0.9542 3210146 TimTec1_001312 CN1CCN(CC1)C(CC(=O)c2ccc(C)cc2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L15 compound treatment 65680.0 -45500.0 -1.77 72400.0 -27200.0 -1.02 -1.9712 -0.966 3082677 TimTec1_001313 C/C(=C/c1ccccc1)/C=N/c2c(C)n(C)n(c3ccccc3)c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L16 compound treatment 48440.0 -62800.0 -2.44 40480.0 -59100.0 -2.22 -3.2913 -0.9989 3210147 TimTec1_001314 Clc1ccccc1C(=O)Oc2ccc(cc2)C3SCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L17 compound treatment 93840.0 -17400.0 -0.67 96320.0 -3270.0 -0.12 -0.5638 -0.8223 3082679 TimTec1_001315 Clc1nsnc1N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L18 compound treatment 95320.0 -15900.0 -0.62 104000.0 4410.0 0.17 -0.3194 -0.4998 1080207 TimTec1_001316 CCn1c(=O)c2ccccc2[nH]c1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L19 compound treatment 17120.0 -94100.0 -3.65 15600.0 -84000.0 -3.15 -4.8109 -0.9973 1587528 TimTec1_001317 Clc1nc2ccccc2n3c(nnc13)c4coc5ccccc5c4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L20 compound treatment 5400.0 -106000.0 -4.11 5120.0 -94500.0 -3.55 -5.4106 -0.9973 3082732 TimTec1_001318 OC(=O)C(CC(=O)c1ccc(Cl)cc1)Sc2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L21 compound treatment 71600.0 -39600.0 -1.54 76880.0 -22700.0 -0.85 -1.6899 -0.9613 3210266 TimTec1_001319 N#Cc1c(SC2CCCC2)nsc1SC3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L22 compound treatment 89640.0 -21600.0 -0.84 82440.0 -17200.0 -0.64 -1.0474 -0.9915 3210267 TimTec1_001320 Cc1n(C)c(c[n+]1c2c3CCCCCn3n(c4ccccc4)c2=O)c5ccc(C)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L23 mock treatment 94840.0 -16400.0 -0.64 82480.0 -17100.0 -0.64 -0.9036 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 L24 mock treatment 82160.0 -29100.0 -1.13 86600.0 -13000.0 -0.49 -1.1422 -0.9297 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M01 compound treatment 35160.0 -76100.0 -2.95 36400.0 -63200.0 -2.37 -3.7639 -0.9941 3082736 TimTec1_001321 Cc1ccc(cc1)S(=O)(=O)N2CCC(=C(O)c3ccccc23)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M02 compound treatment 8280.0 -103000.0 -3.99 7680.0 -91900.0 -3.45 -5.2636 -0.9973 3210268 TimTec1_001322 Cc1nc2C(C(=C(N)N(c2o1)c3ccccc3)C#N)c4c(C)n(nc4Cl)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M03 compound treatment 3920.0 -107000.0 -4.16 4560.0 -95000.0 -3.57 -5.466 -0.997 3082738 TimTec1_001323 Nc1cc(ccc1Oc2ccc(cc2)C3CCCCC3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M04 compound treatment 4960.0 -106000.0 -4.12 4800.0 -94800.0 -3.56 -5.4311 -0.9973 1129265 TimTec1_001324 OC(=O)c1c(SCc2ccc(C#N)cc2)nc(c3cccs3)c4CCCCc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M05 compound treatment 90840.0 -20400.0 -0.79 79520.0 -20100.0 -0.75 -1.0919 -0.9997 1016658 TimTec1_001325 C[N+](C)(C)CCOC(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M06 compound treatment 15080.0 -96100.0 -3.73 11840.0 -87800.0 -3.29 -4.9666 -0.9981 1533994 TimTec1_001326 NC1=C(C#N)C(c2c(noc2N1)c3cccc(O)c3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M07 compound treatment 24760.0 -86500.0 -3.35 19640.0 -80000.0 -3.0 -4.4941 -0.9985 1273967 TimTec1_001327 CCOc1ccc2nc(SCC(=O)c3cccs3)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M08 compound treatment 5880.0 -105000.0 -4.09 5200.0 -94400.0 -3.54 -5.3953 -0.9975 1285313 TimTec1_001328 CC(C)(C)C1CCC2(CC1)C(C#N)C2(C#N)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M09 compound treatment 6080.0 -105000.0 -4.08 5040.0 -94600.0 -3.55 -5.394 -0.9976 1588817 TimTec1_001329 CNc1sc(C(=O)CC=C)c(N)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M10 compound treatment 74040.0 -37200.0 -1.44 57960.0 -41600.0 -1.56 -2.125 -0.9992 1441689 TimTec1_001330 CCOC(=O)c1nc2C(C(=C(N)Nc2o1)C#N)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M11 compound treatment 92280.0 -18900.0 -0.74 71240.0 -28400.0 -1.06 -1.2722 -0.9837 1280958 TimTec1_001331 CCOc1ccc(cc1OC)C2C=C(N)Oc3[nH]c(COC)nc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M12 compound treatment 7200.0 -104000.0 -4.04 6440.0 -93200.0 -3.5 -5.3261 -0.9974 1479215 TimTec1_001332 CCc1ccc(cc1)N2C(=C(C#N)C(c3c(C)noc23)c4cccc(Cl)c4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M13 compound treatment 101120.0 -10100.0 -0.39 80960.0 -18600.0 -0.7 -0.7717 -0.9626 3082744 TimTec1_001333 N#C/C=C/N(C#N)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M14 compound treatment 6240.0 -105000.0 -4.07 6000.0 -93600.0 -3.51 -5.3642 -0.9973 1118063 TimTec1_001334 CCOC(=O)C1C(=C(OC(=C1C#N)N)c2ccc(Cl)cc2)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M15 compound treatment 86440.0 -24800.0 -0.96 72920.0 -26700.0 -1.0 -1.3878 -0.9998 3082746 TimTec1_001335 CCOC(=O)N1CCC2(CC1)C(=C(C)Nc3oc(C)nc32)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M16 compound treatment 68040.0 -43200.0 -1.68 61040.0 -38600.0 -1.45 -2.2079 -0.9973 3210269 TimTec1_001336 CCCc1nc2c(o1)N(C(=O)OCC)C(=C(C#N)C32CCNCC3)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M17 compound treatment 87480.0 -23700.0 -0.92 85560.0 -14000.0 -0.53 -1.0238 -0.9648 1631479 TimTec1_001337 CC(C)N1C(=C(C#N)C2(CCNCC2)C(C#N)C1=O)S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M18 compound treatment 82520.0 -28700.0 -1.11 84120.0 -15500.0 -0.58 -1.1981 -0.9539 3210270 TimTec1_001338 CCN(CC)C(=O)c1cccc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M19 compound treatment 84280.0 -26900.0 -1.05 75880.0 -23700.0 -0.89 -1.3685 -0.9968 1388678 TimTec1_001339 COc1cc(ccc1OCCN2CCOCC2)C3C(=C(C)Nc4oc(C)nc34)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M20 compound treatment 61000.0 -50200.0 -1.95 66680.0 -32900.0 -1.24 -2.2514 -0.9758 3082750 TimTec1_001340 CCOC(=O)c1oc2ccc(/C=N\C(C)(C)C)c(Cl)c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M21 compound treatment 3960.0 -107000.0 -4.16 4040.0 -95600.0 -3.59 -5.4787 -0.9973 3210271 TimTec1_001341 COC(=O)C1=C(OC(=C(C#N)C1c2ccccc2c3ccccc3)C)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M22 compound treatment 60920.0 -50300.0 -1.95 54560.0 -45000.0 -1.69 -2.5752 -0.9974 1636367 TimTec1_001342 CCCCN1COc2ccc(CCNC(=O)c3ccc(Cl)cc3)cc2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M23 mock treatment 89360.0 -21900.0 -0.85 87240.0 -12400.0 -0.46 -0.9277 -0.9596 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 M24 mock treatment 96800.0 -14400.0 -0.56 90760.0 -8830.0 -0.33 -0.6301 -0.9687 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N01 compound treatment 4440.0 -107000.0 -4.14 4040.0 -95600.0 -3.59 -5.4656 -0.9974 3210272 TimTec1_001343 CCc1cc2c(=O)c3c(cn4ccccc34)oc2cc1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N02 compound treatment 27560.0 -83700.0 -3.25 35560.0 -64000.0 -2.4 -3.9947 -0.989 3082752 TimTec1_001344 Nc1nonc1N2C(=N)S/C(=C/c3ccccc3)/C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N03 compound treatment 49800.0 -61400.0 -2.38 51160.0 -48400.0 -1.82 -2.9706 -0.9911 1211420 TimTec1_001345 COc1ccc(cc1)C(=O)N2c3ccccc3CCc4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N04 compound treatment 77800.0 -33400.0 -1.3 78000.0 -21600.0 -0.81 -1.49 -0.9744 1688649 TimTec1_001346 CC(=O)Nc1[nH]c2CCCCCc2c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N05 compound treatment 81280.0 -29900.0 -1.16 93120.0 -6470.0 -0.24 -0.9933 -0.8368 1368911 TimTec1_001347 Clc1c(NCc2ccco2)cnn(c3ccccc3)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N06 compound treatment 90680.0 -20500.0 -0.8 94160.0 -5430.0 -0.2 -0.7078 -0.8602 1227629 TimTec1_001348 COc1ccc(NC2CS(=O)(=O)CC2OC(=O)c3ccc(F)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N07 compound treatment 80160.0 -31100.0 -1.21 72920.0 -26700.0 -1.0 -1.5601 -0.9957 1520272 TimTec1_001349 O=C(Cc1ccccc1)Nc2c(cnn2c3ccccc3)C(=O)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N08 compound treatment 90920.0 -20300.0 -0.79 85600.0 -14000.0 -0.53 -0.9284 -0.9806 1561090 TimTec1_001350 Cc1cc2nc(SCC(=O)NN)[nH]c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N09 compound treatment 60960.0 -50300.0 -1.95 82440.0 -17200.0 -0.64 -1.8342 -0.8931 1634252 TimTec1_001351 O=C(Nc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2)c4ccccn4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N10 compound treatment 58920.0 -52300.0 -2.03 58360.0 -41200.0 -1.55 -2.5293 -0.991 1534295 TimTec1_001352 COc1ccc(NC(=O)c2cccs2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N11 compound treatment 88280.0 -22900.0 -0.89 82680.0 -16900.0 -0.63 -1.0783 -0.9862 3082818 TimTec1_001353 FC(F)(F)c1nc2ccccc2c(=O)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N12 compound treatment 94160.0 -17100.0 -0.66 81920.0 -17700.0 -0.66 -0.9372 -1.0 3210273 TimTec1_001354 Cc1cc(OCc2ccc(Br)cc2)nc(n1)c3ccccc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N13 compound treatment 89040.0 -22200.0 -0.86 78280.0 -21300.0 -0.8 -1.1742 -0.9993 1039615 TimTec1_001355 O=c1n(c2ccccc2)c(nc3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N14 compound treatment 6040.0 -105000.0 -4.08 5560.0 -94000.0 -3.53 -5.3813 -0.9974 3210274 TimTec1_001356 FC(F)(F)c1cc(NC(=O)C(=S)NCc2ccco2)ccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N15 compound treatment 79800.0 -31400.0 -1.22 86920.0 -12700.0 -0.48 -1.1984 -0.9157 3210275 TimTec1_001357 CCOc1nnc(NS(=O)(=O)c2ccc(/N=C/c3ccccc3O)cc2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N16 compound treatment 92040.0 -19200.0 -0.74 85800.0 -13800.0 -0.52 -0.8924 -0.9842 3082822 TimTec1_001358 Cc1sc(Cc2ccc(Cl)cc2)nc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N17 compound treatment 11080.0 -100000.0 -3.89 13400.0 -86200.0 -3.23 -5.035 -0.9958 3082824 TimTec1_001359 N=C1SCC(=O)N1c2nccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N18 compound treatment 19080.0 -92100.0 -3.58 13280.0 -86300.0 -3.24 -4.8187 -0.9988 3210276 TimTec1_001360 CCn1c(SCC(=O)Nc2cccc(Cl)c2Cl)nc3ccccc3c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N19 compound treatment 3920.0 -107000.0 -4.16 3680.0 -95900.0 -3.6 -5.4894 -0.9974 1136080 TimTec1_001361 OC(c1oc2ccccc2c1c3cnn(c3)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N20 compound treatment 9160.0 -102000.0 -3.96 8360.0 -91200.0 -3.42 -5.2214 -0.9974 3210277 TimTec1_001362 FC(F)(F)c1cccc(c1)c2nc3ccccc3c(=O)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N21 compound treatment 6680.0 -105000.0 -4.06 4560.0 -95000.0 -3.57 -5.3903 -0.9979 3210278 TimTec1_001363 FC(F)(F)c1cc(NC(=O)C(=S)NCCNc2cccc3ccccc23)cc(c1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N22 compound treatment 23360.0 -87900.0 -3.41 29160.0 -70400.0 -2.64 -4.2798 -0.9921 3082828 TimTec1_001364 COc1ccc(cc1)c2cs/c(=N\Cc3ccccc3)/[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N23 mock treatment 90800.0 -20400.0 -0.79 88760.0 -10800.0 -0.41 -0.8478 -0.9519 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 N24 mock treatment 93040.0 -18200.0 -0.71 96600.0 -2990.0 -0.11 -0.5783 -0.8094 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O01 compound treatment 37560.0 -73700.0 -2.86 41440.0 -58200.0 -2.18 -3.5643 -0.9911 1081644 TimTec1_001365 COc1cc2CCN=C(CC#N)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O02 compound treatment 3960.0 -107000.0 -4.16 3400.0 -96200.0 -3.61 -5.4957 -0.9975 1714891 TimTec1_001366 COc1cc(OC)cc(c1)[C@@H]2[C@@H](C(C)(C)C)C(C#N)(C#N)[C@@H]3N2C=Cc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O03 compound treatment 56520.0 -54700.0 -2.12 47400.0 -52200.0 -1.96 -2.886 -0.9992 3082830 TimTec1_001367 CSc1nnc(c2ccccc2)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O04 compound treatment 6480.0 -105000.0 -4.06 7200.0 -92400.0 -3.47 -5.3257 -0.9969 3210280 TimTec1_001368 CC(C)(C)OC(=O)N1C(=C(C#N)C2(CCOCC2)c3nc([nH]c13)C(F)(F)F)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O05 compound treatment 63240.0 -48000.0 -1.86 70280.0 -29300.0 -1.1 -2.0944 -0.9685 1332895 TimTec1_001369 Cc1cc(=O)oc2cc(OC3OC(CO)C(O)C(O)C3O)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O06 compound treatment 7960.0 -103000.0 -4.01 8240.0 -91400.0 -3.43 -5.2575 -0.997 1308936 TimTec1_001370 Fc1ccc(cc1)C(=O)CSC2=C(C#N)C(=O)C(C#N)C3(CCCC3)N2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O07 compound treatment 4960.0 -106000.0 -4.12 4960.0 -94600.0 -3.55 -5.4269 -0.9972 3210391 TimTec1_001371 O=C(NCCOc1ccccc1c2ccccc2)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O08 compound treatment 56280.0 -54900.0 -2.13 52840.0 -46800.0 -1.75 -2.7482 -0.9953 1195667 TimTec1_001372 Cc1ccc(cc1)C(=O)[C@@H]2[C@@H](C(C)(C)C)C(C#N)(C#N)[C@@]3(C)C=Cc4ccccc4N23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O09 compound treatment 7880.0 -103000.0 -4.01 10720.0 -88900.0 -3.34 -5.1939 -0.9958 1300208 TimTec1_001373 Nc1sc(Nc2ccccc2)c(C#N)c1C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O10 compound treatment 4920.0 -106000.0 -4.12 4320.0 -95300.0 -3.58 -5.445 -0.9975 3210392 TimTec1_001374 COC(=O)c1ccc(cc1)[C@@H]2[C@H]3CC(CC=C3C(C#N)(C#N)C(=C2C#N)N)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O11 compound treatment 72920.0 -38300.0 -1.49 63480.0 -36100.0 -1.36 -2.0093 -0.9989 1596487 TimTec1_001375 CCCc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3cccc(O)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O12 compound treatment 21800.0 -89400.0 -3.47 27800.0 -71800.0 -2.69 -4.3587 -0.9922 3082899 TimTec1_001376 COc1ccc(cc1)[C@H]2NC(=C(C#N)C(=O)[C@@H]2[n+]3ccccc3)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O13 compound treatment 91200.0 -20000.0 -0.78 80800.0 -18800.0 -0.71 -1.0481 -0.9988 3210393 TimTec1_001377 NC1=C(C#N)C(c2nc(oc2N1c3ccccc3)c4ccccc4)c5cccc(O)c5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O14 compound treatment 7200.0 -104000.0 -4.04 5160.0 -94400.0 -3.54 -5.3601 -0.9979 1397691 TimTec1_001378 CC1=C(C(C(=C(N)S1)C#N)c2ccoc2)C(=O)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O15 compound treatment 10040.0 -101000.0 -3.93 8120.0 -91500.0 -3.43 -5.2036 -0.9978 1415097 TimTec1_001379 CCCc1nc2C(C(=C(N)Nc2o1)C#N)c3ccc(OC(C)C)c(OC)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O16 compound treatment 90840.0 -20400.0 -0.79 76200.0 -23400.0 -0.88 -1.1801 -0.9986 3210394 TimTec1_001380 Clc1cccc(c1)C(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O17 compound treatment 4560.0 -107000.0 -4.14 4040.0 -95600.0 -3.59 -5.4623 -0.9975 3082903 TimTec1_001381 Cc1nc2C(C(=C(N)Nc2o1)C#N)c3c[nH]nc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O18 compound treatment 32840.0 -78400.0 -3.04 19120.0 -80500.0 -3.02 -4.2862 -1.0 1268817 TimTec1_001382 COc1ccccc1NC(=O)c2ccc(cc2)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O19 compound treatment 4040.0 -107000.0 -4.16 3760.0 -95800.0 -3.6 -5.484 -0.9974 3210395 TimTec1_001383 COc1cccc(c1)[C@@H]2[C@H]3CC(C)CC=C3C(C#N)(C#N)C(=C2C#N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O20 compound treatment 70280.0 -40900.0 -1.59 74000.0 -25600.0 -0.96 -1.8025 -0.971 1627987 TimTec1_001384 CCOC(=O)c1c(NC(=O)C)sc2C(=O)NCCCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O21 compound treatment 51840.0 -59400.0 -2.3 51440.0 -48200.0 -1.81 -2.9072 -0.9928 1713250 TimTec1_001385 CC(C)NC(=O)CSc1cc(c2cccnc2)c3CCCCc3c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O22 compound treatment 11920.0 -99300.0 -3.85 15400.0 -84200.0 -3.16 -4.9589 -0.9951 3210396 TimTec1_001386 CCOC(=O)c1c(N)sc2C(=O)C(CCc12)Sc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O23 mock treatment 97040.0 -14200.0 -0.55 89920.0 -9670.0 -0.36 -0.6458 -0.9796 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 O24 mock treatment 113480.0 2260.0 0.09 101840.0 2250.0 0.08 0.1216 0.9998 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P01 compound treatment 92200.0 -19000.0 -0.74 97400.0 -2190.0 -0.08 -0.5801 -0.781 3082907 TimTec1_001387 COc1ccc2c(=S)c(c3cc4ccccc4o3)c(C)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P02 compound treatment 82240.0 -29000.0 -1.12 81040.0 -18600.0 -0.7 -1.2876 -0.9734 1033890 TimTec1_001388 C(Cc1nc2ccccc2[nH]1)Cc3nc4ccccc4[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P03 compound treatment 67800.0 -43400.0 -1.68 79160.0 -20400.0 -0.77 -1.7336 -0.9365 3082909 TimTec1_001389 S=CC1=C2NCCCN2C3CCCCC31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P04 compound treatment 75440.0 -35800.0 -1.39 80120.0 -19500.0 -0.73 -1.4985 -0.9551 1117255 TimTec1_001390 NC(=N)c1cccc(NC(=O)Nc2cccc(c2)C(=N)N)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P05 compound treatment 86920.0 -24300.0 -0.94 88600.0 -11000.0 -0.41 -0.9585 -0.9312 1246425 TimTec1_001391 Cc1c(NC2CS(=O)(=O)CC2O)c(=O)n(c3ccccc3)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P06 compound treatment 93240.0 -18000.0 -0.7 62520.0 -37100.0 -1.39 -1.4773 -0.9491 1671747 TimTec1_001392 O=c1c(C2=NCCCCC2)c3[nH]c(cn3n1c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P07 compound treatment 75960.0 -35300.0 -1.37 72160.0 -27400.0 -1.03 -1.6955 -0.9902 1595982 TimTec1_001393 CCCN(CCC)C(=O)c1c(NC(=O)c2ccco2)sc3CC(C)CCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P08 compound treatment 80400.0 -30800.0 -1.2 83760.0 -15800.0 -0.59 -1.2658 -0.9479 1216494 TimTec1_001394 NNC(=O)c1ccc2c(=O)[nH][nH]c(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P09 compound treatment 67800.0 -43400.0 -1.68 57040.0 -42600.0 -1.6 -2.3207 -0.9996 1492209 TimTec1_001395 O=c1[nH]c(nc2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P10 compound treatment 74680.0 -36500.0 -1.42 69320.0 -30300.0 -1.14 -1.806 -0.994 1735994 TimTec1_001396 CCn1c(N)c(sc1=S)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P11 compound treatment 51520.0 -59700.0 -2.32 50560.0 -49000.0 -1.84 -2.9393 -0.9935 1341596 TimTec1_001397 CCc1nc2ccccc2c(=O)n1c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P12 compound treatment 45760.0 -65500.0 -2.54 39080.0 -60500.0 -2.27 -3.402 -0.9984 1919107 TimTec1_001398 Cc1cc(NCCCN2CCOCC2)nc(n1)c3ccccc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P13 compound treatment 82160.0 -29100.0 -1.13 79000.0 -20600.0 -0.77 -1.3439 -0.983 1420208 TimTec1_001399 CCOC(=O)c1c(NC(=O)C2C(C)(C)C2(C)C)sc3CCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P14 compound treatment 90840.0 -20400.0 -0.79 86680.0 -12900.0 -0.48 -0.9019 -0.9723 1140583 TimTec1_001400 COc1ccc(C)cc1NC(=O)C(=S)NCc2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P15 compound treatment 85560.0 -25700.0 -1.0 78880.0 -20700.0 -0.78 -1.2538 -0.9925 3210397 TimTec1_001401 NC(=N)NS(=O)(=O)c1ccc(/N=C/c2ccccc2O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P16 compound treatment 75680.0 -35500.0 -1.38 71960.0 -27600.0 -1.04 -1.7085 -0.9901 1142293 TimTec1_001402 O=C(Oc1ccc(cc1)C2SCCS2)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P17 compound treatment 79160.0 -32100.0 -1.24 77200.0 -22400.0 -0.84 -1.474 -0.9818 1739320 TimTec1_001403 Clc1ccccc1C(=O)Nc2nonc2NC=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P18 compound treatment 52320.0 -58900.0 -2.29 54680.0 -44900.0 -1.69 -2.808 -0.9888 1453837 TimTec1_001404 O=C(Cc1ccccc1)c2ccccc2C(=O)NCc3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P19 compound treatment 66560.0 -44700.0 -1.73 67600.0 -32000.0 -1.2 -2.0744 -0.9839 1670037 TimTec1_001405 CCc1cccc(CC)c1NC(=O)COc2ccccc2C(=O)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P20 compound treatment 72800.0 -38400.0 -1.49 72760.0 -26800.0 -1.01 -1.7663 -0.9817 3210398 TimTec1_001406 CC(C)Cc1ccc(/C=C/C(=O)N2CCN(C\C=C\c3ccccc3)CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P21 compound treatment 56960.0 -54300.0 -2.11 58880.0 -40700.0 -1.53 -2.5692 -0.9876 3082991 TimTec1_001407 Cc1nc(SCc2noc(CSc3nc(C)c(C)c(C)c3C#N)n2)c(C#N)c(C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P22 compound treatment 62200.0 -49000.0 -1.9 62960.0 -36600.0 -1.37 -2.3172 -0.9873 3210399 TimTec1_001408 Cc1ccc2NC(=O)/C(=N\N3C(=O)c4ccccc4C3=O)/c2c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P23 mock treatment 95160.0 -16100.0 -0.62 79200.0 -20400.0 -0.77 -0.9819 -0.9948 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2066 P24 mock treatment 103960.0 -7270.0 -0.28 93760.0 -5830.0 -0.22 -0.3541 -0.9922 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A01 compound treatment 4760.0 -84400.0 -3.27 1920.0 -68700.0 -2.58 -4.137 -0.993 1609023 TimTec1_001409 COc1ccc(CC(=O)n2[nH]c(=O)ccc2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A02 compound treatment 6920.0 -82200.0 -3.19 2600.0 -68000.0 -2.55 -4.0597 -0.9939 3210400 TimTec1_001410 CCN1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A03 compound treatment 85080.0 -4050.0 -0.16 51920.0 -18700.0 -0.7 -0.6064 -0.8447 3210401 TimTec1_001411 OCC1OC(C(O)C1O)N2C3CCNC(=O)C3N=C2N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A04 compound treatment 100640.0 11500.0 0.45 50840.0 -19700.0 -0.74 -0.2081 -0.2405 1501937 TimTec1_001412 O=C(Nc1cccc(c1)N2CCCC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A05 compound treatment 87080.0 -2050.0 -0.08 47120.0 -23500.0 -0.88 -0.6789 -0.7678 1302244 TimTec1_001413 CS(=O)(=O)N(Cc1ccccc1)c2ccccc2C(=O)NC3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A06 compound treatment 84520.0 -4610.0 -0.18 34160.0 -36400.0 -1.37 -1.0931 -0.7928 3082998 TimTec1_001414 Nc1nc(SCc2ccccc2)n(n1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A07 compound treatment 90080.0 953.0 0.04 46360.0 -24200.0 -0.91 -0.6167 -0.6778 1224047 TimTec1_001415 COc1ccccc1c2nn(CNc3ccccc3)c(=S)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A08 compound treatment 83400.0 -5730.0 -0.22 36640.0 -33900.0 -1.27 -1.058 -0.8181 3083000 TimTec1_001416 CCOC(=O)c1sc(SC)nc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A09 compound treatment 85240.0 -3890.0 -0.15 39440.0 -31100.0 -1.17 -0.9332 -0.7918 1232083 TimTec1_001417 Brc1ccc2C(=O)N(C(c3ccccc3)c4ccccc4)C(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A10 compound treatment 93320.0 4190.0 0.16 51280.0 -19300.0 -0.72 -0.3973 -0.535 1258394 TimTec1_001418 CCN(CC)C(=O)c1c[nH]c2ccccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A11 compound treatment 13600.0 -75500.0 -2.93 7640.0 -62900.0 -2.36 -3.7426 -0.9943 1352649 TimTec1_001419 C(N1CCCN(Cc2ccccc2)C1c3ccncc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A12 compound treatment 54920.0 -34200.0 -1.33 43000.0 -27600.0 -1.04 -1.6706 -0.9924 1285436 TimTec1_001420 Brc1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A13 compound treatment 98840.0 9710.0 0.38 67000.0 -3580.0 -0.13 0.1714 0.4283 3210402 TimTec1_001421 COc1cc(cc(OC)c1OC)C/2=NOC(=O)\C2=C/c3ccc(Cl)cc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A14 compound treatment 100760.0 11600.0 0.45 56640.0 -13900.0 -0.52 -0.0509 -0.0737 3083004 TimTec1_001422 CC1(C)CC(=O)C2=C(C1)OC3=C(C2c4cccnc4)C(=O)CC(C)(C)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A15 compound treatment 104080.0 15000.0 0.58 61520.0 -9060.0 -0.34 0.1697 0.2523 3210403 TimTec1_001423 CSc1sc(C)cc1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A16 compound treatment 90560.0 1430.0 0.06 38240.0 -32300.0 -1.21 -0.8191 -0.674 1473282 TimTec1_001424 N=c1[nH]c(cs1)c2ccc3OCCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A17 compound treatment 16160.0 -73000.0 -2.83 5240.0 -65300.0 -2.45 -3.7361 -0.9974 1291516 TimTec1_001425 Nc1nonc1NC(=O)CSc2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A18 compound treatment 105360.0 16200.0 0.63 64120.0 -6460.0 -0.24 0.2738 0.4057 1069221 TimTec1_001426 CSc1nnnn1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A19 compound treatment 15240.0 -73900.0 -2.87 7280.0 -63300.0 -2.38 -3.7072 -0.9956 1502089 TimTec1_001427 COc1ccc(cc1)C2C3CCC=C3C(=C(N)C2(C#N)C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A20 compound treatment 104600.0 15500.0 0.6 69120.0 -1460.0 -0.05 0.3857 0.6397 1057528 TimTec1_001428 CC(=O)Oc1cccc2ccc(O)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A21 compound treatment 100320.0 11200.0 0.43 66680.0 -3900.0 -0.15 0.2035 0.444 3210521 TimTec1_001429 Cc1c(C)c(/C=N/O)c(C)c(C)c1/C=N/O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A22 compound treatment 111720.0 22600.0 0.88 59520.0 -11100.0 -0.42 0.3262 0.3363 1551108 TimTec1_001430 CCOC(=O)C1CCN(CC1)C(=O)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A23 mock treatment 110640.0 21500.0 0.83 74000.0 3420.0 0.13 0.6809 0.8063 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 A24 mock treatment 84280.0 -4850.0 -0.19 70000.0 -584.0 -0.02 -0.1485 -0.7842 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B01 compound treatment 109160.0 20000.0 0.78 74960.0 4380.0 0.16 0.6658 0.838 1318272 TimTec1_001431 COc1ccc2nc(sc2c1)C(=O)N3CCN(C)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B02 compound treatment 4440.0 -84700.0 -3.29 2560.0 -68000.0 -2.55 -4.1288 -0.9922 1256461 TimTec1_001432 OC(=O)c1ccc(Nc2nnc(c3ccccc3)c(n2)c4ccccc4)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B03 compound treatment 75640.0 -13500.0 -0.52 22960.0 -47600.0 -1.79 -1.6339 -0.8773 3083011 TimTec1_001433 FC(F)(F)c1cccc(c1)c2ccc(/C=C(\C#N)/c3ccccc3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B04 compound treatment 115680.0 26600.0 1.03 77000.0 6420.0 0.24 0.8988 0.8495 3210522 TimTec1_001434 C(C1COC(=N1)C2=N[C@@H](Cc3ccccc3)CO2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B05 compound treatment 135640.0 46500.0 1.8 87880.0 17300.0 0.65 1.7351 0.9047 3083012 TimTec1_001435 Cc1nnc(/N=C/2\S/C(=C/c3ccc(cc3)C(=O)O)/C(=O)N2CC=C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B06 compound treatment 126680.0 37600.0 1.46 80000.0 9420.0 0.35 1.2802 0.8539 3210523 TimTec1_001436 C/C(=N\O)/c1ccc2OCCOCCOCCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B07 compound treatment 91240.0 2110.0 0.08 45720.0 -24900.0 -0.93 -0.6019 -0.6425 1208416 TimTec1_001437 O=C1N(CSc2nc3ccccc3s2)c4cccc5cccc1c45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B08 compound treatment 6840.0 -82300.0 -3.19 3120.0 -67500.0 -2.53 -4.048 -0.9934 3210524 TimTec1_001438 C[C@@H]1[C@@H]2CCC3[C@@](C)(CC(=O)O)CCC[C@]3(C)C2Cc4occc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B09 compound treatment 119480.0 30400.0 1.18 68880.0 -1700.0 -0.06 0.7875 0.6677 1668666 TimTec1_001439 C(SCc1ccccc1)c2cn3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B10 compound treatment 7760.0 -81400.0 -3.16 3960.0 -66600.0 -2.5 -4.0005 -0.9933 3210525 TimTec1_001440 ONC(=O)c1cccc2/C(=N\O)/c3ccccc3-c21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B11 compound treatment 116560.0 27400.0 1.06 76960.0 6380.0 0.24 0.9219 0.845 3083091 TimTec1_001441 CCCOc1ccc(/C=C/C(=O)Nc2nnc[nH]2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B12 compound treatment 23160.0 -66000.0 -2.56 12720.0 -57900.0 -2.17 -3.3455 -0.9967 1621908 TimTec1_001442 NS(=O)(=O)c1nn2cc(nc2s1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B13 compound treatment 87760.0 -1370.0 -0.05 54640.0 -15900.0 -0.6 -0.4606 -0.7668 1239473 TimTec1_001443 Clc1c(NCc2ccccc2)cn[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B14 compound treatment 96880.0 7750.0 0.3 72800.0 2220.0 0.08 0.2715 0.87 3210526 TimTec1_001444 OC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)/C=C/c3ccccn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B15 compound treatment 125640.0 36500.0 1.42 90160.0 19600.0 0.73 1.5213 0.9533 3210527 TimTec1_001445 Brc1cc(c2coc3ccccc3c2=O)c4OCOCc4c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B16 compound treatment 7760.0 -81400.0 -3.16 4160.0 -66400.0 -2.49 -3.9952 -0.9932 3083094 TimTec1_001446 COc1cc(SC#N)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B17 compound treatment 89640.0 513.0 0.02 32520.0 -38100.0 -1.43 -0.9961 -0.6972 1121522 TimTec1_001447 COc1ccc(CCCc2nc3ccccc3[nH]2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B18 compound treatment 118520.0 29400.0 1.14 55680.0 -14900.0 -0.56 0.4109 0.3235 3210528 TimTec1_001448 CNC(=S)Nc1ccc(OC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B19 compound treatment 57440.0 -31700.0 -1.23 19840.0 -50700.0 -1.9 -2.2161 -0.9776 1022826 TimTec1_001449 O=C(Nc1ccccc1)Oc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B20 compound treatment 132880.0 43800.0 1.7 67240.0 -3340.0 -0.13 1.1116 0.6531 3083097 TimTec1_001450 CC1CCCCN1C(=O)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B21 compound treatment 102560.0 13400.0 0.52 43520.0 -27100.0 -1.02 -0.3497 -0.3063 3210529 TimTec1_001451 O=C(NCc1ccco1)c2ccccc2N(Cc3ccccc3)S(=O)(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B22 compound treatment 120880.0 31800.0 1.23 45560.0 -25000.0 -0.94 0.2071 0.1337 1271782 TimTec1_001452 CC(=O)Oc1ccc2c(NC3(OC(=O)C)C(=O)c4ccccc4C23OC(=O)C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B23 mock treatment 116800.0 27700.0 1.07 64920.0 -5660.0 -0.21 0.6089 0.5563 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 B24 mock treatment 103360.0 14200.0 0.55 62960.0 -7620.0 -0.29 0.1882 0.3025 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C01 compound treatment 84080.0 -5050.0 -0.2 50600.0 -20000.0 -0.75 -0.6688 -0.8628 1645231 TimTec1_001453 CCn1cnc2c(=O)[nH][nH]c(=O)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C02 compound treatment 16040.0 -73100.0 -2.84 3880.0 -66700.0 -2.5 -3.7755 -0.9981 2086755 TimTec1_001454 CCOC(=O)N1C/C(=C\c2ccccc2)/C(=O)\C(=C\c3ccccc3)\C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C03 compound treatment 91760.0 2630.0 0.1 43640.0 -26900.0 -1.01 -0.6428 -0.6325 1308938 TimTec1_001455 CCc1cc2c(=O)c(coc2cc1OC(C)C(=O)O)c3csc(C)n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C04 compound treatment 95760.0 6630.0 0.26 50440.0 -20100.0 -0.76 -0.3526 -0.4415 1446072 TimTec1_001456 CC1CCCN(C1)C(=O)c2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C05 compound treatment 12080.0 -77000.0 -2.99 4800.0 -65800.0 -2.47 -3.8597 -0.9955 1636408 TimTec1_001457 Cc1ccc(NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)OCc4ccccc4)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C06 compound treatment 6960.0 -82200.0 -3.19 4760.0 -65800.0 -2.47 -4.0012 -0.9921 3083101 TimTec1_001458 Nc1n/c(=N\c2ccccc2)/ss1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C07 compound treatment 85480.0 -3650.0 -0.14 52160.0 -18400.0 -0.69 -0.589 -0.8345 1676195 TimTec1_001459 CCSc1nc2ccccc2n1CC(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C08 compound treatment 38600.0 -50500.0 -1.96 8120.0 -62500.0 -2.34 -3.044 -0.996 3083103 TimTec1_001460 CSc1nc(N)c(s1)C(=O)Nc2ccc(cc2)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C09 compound treatment 72040.0 -17100.0 -0.66 55640.0 -14900.0 -0.56 -0.8654 -0.9965 3210530 TimTec1_001461 Cc1nc2ccc(/N=C/c3ccccc3O)cc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C10 compound treatment 6600.0 -82500.0 -3.2 4120.0 -66500.0 -2.49 -4.0281 -0.9924 1342383 TimTec1_001462 O=C(N(Cc1ccccc1)Cc2ccccc2)c3c[nH]c4ccccc4c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C11 compound treatment 91560.0 2430.0 0.09 70040.0 -544.0 -0.02 0.0523 0.5417 1668351 TimTec1_001463 OC(=O)C1CCCN1C(=O)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C12 compound treatment 88200.0 -928.0 -0.04 67400.0 -3180.0 -0.12 -0.1099 -0.881 1266673 TimTec1_001464 O=C(Nc1ncccn1)c2c[nH]c3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C13 compound treatment 86960.0 -2170.0 -0.08 70120.0 -464.0 -0.02 -0.0718 -0.8357 3083106 TimTec1_001465 Fc1ccccc1C/2=NOC(=O)\C2=C/Nc3ccc(Cl)cn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C14 compound treatment 84480.0 -4650.0 -0.18 60960.0 -9620.0 -0.36 -0.3829 -0.9485 1516165 TimTec1_001466 CCOC(=O)C1=C(C)OC(=C(C1c2cccnc2)C(=O)OCC)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C15 compound treatment 77400.0 -11700.0 -0.46 52760.0 -17800.0 -0.67 -0.7948 -0.9824 3083108 TimTec1_001467 CSc1sc(C)cc1/C=N/O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C16 compound treatment 66160.0 -23000.0 -0.89 35800.0 -34800.0 -1.31 -1.5533 -0.9827 3210531 TimTec1_001468 Clc1ccc(NC(=O)/N=c/2\[nH]c(cs2)c3ccccc3)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C17 compound treatment 64120.0 -25000.0 -0.97 26960.0 -43600.0 -1.64 -1.8438 -0.9688 3083183 TimTec1_001469 Nc1nonc1NC(=O)CSC(=N)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C18 compound treatment 7680.0 -81400.0 -3.16 3880.0 -66700.0 -2.5 -4.0048 -0.9933 1579055 TimTec1_001470 COc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C19 compound treatment 9880.0 -79200.0 -3.07 4600.0 -66000.0 -2.48 -3.9254 -0.9942 1328959 TimTec1_001471 CCOc1ccc(OCC)c(c1)C2C(Cc3ccccc3)N4C(C=Cc5ccccc45)C2(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C20 compound treatment 105800.0 16700.0 0.65 61960.0 -8620.0 -0.32 0.2286 0.316 3083185 TimTec1_001472 COC(=O)Nc1nccs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C21 compound treatment 96280.0 7150.0 0.28 41760.0 -28800.0 -1.08 -0.5687 -0.5092 1288354 TimTec1_001473 Cc1ccc(c(C)c1)c2c(C#N)c(N)n(C)c(=O)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C22 compound treatment 47640.0 -41500.0 -1.61 43520.0 -27100.0 -1.02 -1.8565 -0.9754 1283442 TimTec1_001474 O=C(Nc1ccc2OCOc2c1)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C23 mock treatment 112440.0 23300.0 0.9 67680.0 -2900.0 -0.11 0.5625 0.6174 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 C24 mock treatment 110480.0 21400.0 0.83 64920.0 -5660.0 -0.21 0.4355 0.5092 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D01 compound treatment 5080.0 -84000.0 -3.26 3000.0 -67600.0 -2.54 -4.0995 -0.9923 3083186 TimTec1_001475 O=C1CC(Sc2ccc3ccccc3c2)C4COC1O4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D02 compound treatment 105880.0 16800.0 0.65 87880.0 17300.0 0.65 0.9186 1.0 1501922 TimTec1_001476 OC(=O)c1nn(Cc2ccccc2)nc1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D03 compound treatment 88600.0 -528.0 -0.02 71440.0 856.0 0.03 0.0083 0.2166 3210532 TimTec1_001477 S/C(=C(/C(=O)c1ccccc1)\[n+]2ccccc2)/NC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D04 compound treatment 111760.0 22600.0 0.88 95120.0 24500.0 0.92 1.2721 0.9997 3083190 TimTec1_001478 O=C(N[C@@H]1COC(=O)C1)OCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D05 compound treatment 106560.0 17400.0 0.68 78480.0 7900.0 0.3 0.6878 0.9314 3210533 TimTec1_001479 O=C(C(=C1Nc2ccccc2N1)C#N)c3cc[n+](Cc4ccccc4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D06 compound treatment 117080.0 28000.0 1.08 91560.0 21000.0 0.79 1.3236 0.9876 3083192 TimTec1_001480 OC(=O)c1ccc(/C=C/C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D07 compound treatment 81360.0 -7770.0 -0.3 75640.0 5060.0 0.19 -0.0789 -0.2216 1703831 TimTec1_001481 Brc1ccc(NC(=O)C2(CCN3CC2)c4ccccc4C3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D08 compound treatment 96120.0 6990.0 0.27 78400.0 7820.0 0.29 0.3993 0.9992 1474907 TimTec1_001482 OC1CC(c2ccccc2Cl)C3(C(C1)c4ccccc4Cl)C(=O)NC(=O)NC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D09 compound treatment 100400.0 11300.0 0.44 80480.0 9900.0 0.37 0.5719 0.9967 3210647 TimTec1_001483 Cc1cccn2c(=O)c(/C=N/c3ccc(Cl)cc3)c(Sc4ccccc4)nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D10 compound treatment 7760.0 -81400.0 -3.16 5240.0 -65300.0 -2.45 -3.9665 -0.9922 3083196 TimTec1_001484 Cc1ccc(cc1)S(=O)(=O)c2ccc(/C=C/c3ccco3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D11 compound treatment 104280.0 15200.0 0.59 85400.0 14800.0 0.56 0.8089 0.9996 1185515 TimTec1_001485 O=C(NCCc1nc2ccccc2[nH]1)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D12 compound treatment 102440.0 13300.0 0.52 76720.0 6140.0 0.23 0.5281 0.9338 3083198 TimTec1_001486 COc1ccc(/C=C/2\N=C(N(C2=O)c3nc4ccc(cc4s3)C(=O)O)c5ccccc5)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D13 compound treatment 96280.0 7150.0 0.28 79920.0 9340.0 0.35 0.444 0.9933 1329192 TimTec1_001487 Cc1cc(=O)n2c3C(=O)N(Cc4ccccc4)C(=O)c3sc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D14 compound treatment 105840.0 16700.0 0.65 91440.0 20900.0 0.78 1.012 0.9956 3210648 TimTec1_001488 CC(=O)Nc1ccc(cc1C(=O)O)S(=O)(=O)NN2C(=O)/C(=C/c3ccco3)/N=C2c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D15 compound treatment 107480.0 18400.0 0.71 89240.0 18700.0 0.7 0.9986 1.0 3083200 TimTec1_001489 Cc1nnc(C)n1/N=C/c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D16 compound treatment 79080.0 -10000.0 -0.39 51840.0 -18700.0 -0.7 -0.7731 -0.9612 1026134 TimTec1_001490 O=C(c1cc2ccccc2o1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D17 compound treatment 98600.0 9470.0 0.37 70680.0 96.3 0.0 0.2624 0.714 1337169 TimTec1_001491 CCCC(=O)c1ccc(cc1)C(C)CCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D18 compound treatment 102920.0 13800.0 0.54 66000.0 -4580.0 -0.17 0.2568 0.4568 1082112 TimTec1_001492 COc1cccc(NC(=S)Nc2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D19 compound treatment 104400.0 15300.0 0.59 86160.0 15600.0 0.58 0.8324 1.0 1198422 TimTec1_001493 NC(=O)CCNC(=O)C(c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D20 compound treatment 108200.0 19100.0 0.74 76920.0 6340.0 0.24 0.6914 0.8895 1112637 TimTec1_001494 CCC(C)NC(=O)c1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D21 compound treatment 48680.0 -40400.0 -1.57 32880.0 -37700.0 -1.42 -2.1103 -0.9987 3210649 TimTec1_001495 Fc1ccc(cc1)c2cs/c(=N\c3ccccc3)/n2Cc4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D22 compound treatment 71600.0 -17500.0 -0.68 43440.0 -27100.0 -1.02 -1.2012 -0.9807 1228411 TimTec1_001496 OC1(C2C(=O)NC(=O)NC2=O)C(=O)c3ccccc3C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D23 mock treatment 95880.0 6750.0 0.26 62360.0 -8220.0 -0.31 -0.033 -0.0815 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 D24 mock treatment 100880.0 11800.0 0.46 61120.0 -9460.0 -0.36 0.0713 0.1233 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E01 compound treatment 78840.0 -10300.0 -0.4 49960.0 -20600.0 -0.77 -0.8296 -0.9526 1636299 TimTec1_001497 COc1ccc2C=CC3C=CC(O)C4Oc1c2C43CCN(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E02 compound treatment 6200.0 -82900.0 -3.22 4880.0 -65700.0 -2.47 -4.0189 -0.9914 3083205 TimTec1_001498 CC(C)(C)C1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E03 compound treatment 87520.0 -1610.0 -0.06 61080.0 -9500.0 -0.36 -0.2963 -0.8183 3210650 TimTec1_001499 Cn1c(=O)c(C2=NNC3=NNC(C23)c4ccccc4)c(O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E04 compound treatment 90800.0 1670.0 0.06 70200.0 -384.0 -0.01 0.0357 0.5371 3083208 TimTec1_001500 O=C(N1CCCCC1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E05 compound treatment 88840.0 -288.0 -0.01 66360.0 -4220.0 -0.16 -0.12 -0.755 1501857 TimTec1_001501 COc1ccc(NC(=O)CC2CS(=O)(=O)CC2CC(=O)Nc3ccc(OC)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E06 compound treatment 71640.0 -17500.0 -0.68 65320.0 -5260.0 -0.2 -0.6195 -0.8766 1493097 TimTec1_001502 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2cnnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E07 compound treatment 70800.0 -18300.0 -0.71 48640.0 -21900.0 -0.82 -1.0852 -0.9973 3210651 TimTec1_001503 Oc1ccc(/C=N/c2ccc(cc2)N3CCOCC3)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E08 compound treatment 85080.0 -4050.0 -0.16 72440.0 1860.0 0.07 -0.0618 -0.3596 1097150 TimTec1_001504 COc1ccc(NC(=O)c2sc(SC)nc2N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E09 compound treatment 36160.0 -53000.0 -2.06 7120.0 -63500.0 -2.38 -3.1375 -0.9973 3210652 TimTec1_001505 O=C/1Nc2ccccc2\C1=N/N3C(=O)C4C=CC=CC4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E10 compound treatment 41640.0 -47500.0 -1.84 32480.0 -38100.0 -1.43 -2.3141 -0.9922 1413901 TimTec1_001506 O=C(N(c1ccccc1)c2ccccc2)c3c[nH]c4ccccc4c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E11 compound treatment 67200.0 -21900.0 -0.85 72360.0 1780.0 0.07 -0.5545 -0.6497 3210653 TimTec1_001507 CC(C)(C)C(=O)CSc1ncnc2[nH]cnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E12 compound treatment 87160.0 -1970.0 -0.08 72080.0 1500.0 0.06 -0.0143 -0.1506 1279481 TimTec1_001508 CCOC(=O)CC(N)c1ccccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E13 compound treatment 7720.0 -81400.0 -3.16 5760.0 -64800.0 -2.43 -3.9538 -0.9917 3210654 TimTec1_001509 CCc1sc2sncc2c1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E14 compound treatment 41480.0 -47600.0 -1.85 19640.0 -50900.0 -1.91 -2.6592 -0.9999 1490642 TimTec1_001510 Cc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3C(=O)CC(C)(C)CC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E15 compound treatment 100160.0 11000.0 0.43 76680.0 6100.0 0.23 0.4645 0.9569 3082121 TimTec1_001511 CCSc1cc(CC)sc1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E16 compound treatment 86920.0 -2210.0 -0.09 33080.0 -37500.0 -1.41 -1.0559 -0.7487 3082123 TimTec1_001512 CN(C(=O)CSC(=S)N1CCCC1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E17 compound treatment 91840.0 2710.0 0.11 75560.0 4980.0 0.19 0.2065 0.9632 3210655 TimTec1_001513 CCOC(=O)/C=C(/C)\Nc1nonc1NC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E18 compound treatment 92840.0 3710.0 0.14 75720.0 5140.0 0.19 0.2382 0.9897 3082125 TimTec1_001514 Nc1nnc(o1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E19 compound treatment 76800.0 -12300.0 -0.48 56120.0 -14500.0 -0.54 -0.7221 -0.998 1386928 TimTec1_001515 Cc1ccc(C2C(Cc3ccccc3)N4C=Cc5ccccc5C4C2(C#N)C(=O)N)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E20 compound treatment 80560.0 -8570.0 -0.33 50760.0 -19800.0 -0.74 -0.7612 -0.934 3082127 TimTec1_001516 CCOC(=O)Cc1ccccc1C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E21 compound treatment 6960.0 -82200.0 -3.19 4800.0 -65800.0 -2.47 -4.0002 -0.992 3210656 TimTec1_001517 O=C/1/C(=C/C2CCCO2)/CC\C1=C/C3CCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E22 compound treatment 79600.0 -9530.0 -0.37 61720.0 -8860.0 -0.33 -0.4966 -0.9986 1433367 TimTec1_001518 CC(C)C(=O)Nc1ccc(cc1)c2nc3cc(C)ccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E23 mock treatment 94640.0 5510.0 0.21 76760.0 6180.0 0.23 0.3152 0.9992 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 E24 mock treatment 89360.0 233.0 0.01 62720.0 -7860.0 -0.3 -0.2023 -0.6852 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F01 compound treatment 99120.0 9990.0 0.39 69880.0 -704.0 -0.03 0.2555 0.6574 1232600 TimTec1_001519 COCC(=O)OCC1CCCN2CCCCC12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F02 compound treatment 109240.0 20100.0 0.78 81800.0 11200.0 0.42 0.8495 0.958 3082129 TimTec1_001520 CC(=O)OCc1cnn(n1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F03 compound treatment 83480.0 -5650.0 -0.22 63760.0 -6820.0 -0.26 -0.336 -0.997 3210657 TimTec1_001521 O=C(CCCN1C(=O)S/C(=C/c2ccccc2)/C1=S)NC3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F04 compound treatment 112400.0 23300.0 0.9 92280.0 21700.0 0.81 1.2143 0.9987 1023719 TimTec1_001522 Clc1ncnc2n(cnc12)C3CCCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F05 compound treatment 84840.0 -4290.0 -0.17 69880.0 -704.0 -0.03 -0.1363 -0.8092 3210658 TimTec1_001523 CCc1nnc(/N=C/2\S/C(=C/c3ccc(cc3)C(=O)O)/C(=O)N2CC=C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F06 compound treatment 120600.0 31500.0 1.22 89680.0 19100.0 0.72 1.3703 0.9678 3082133 TimTec1_001524 Brc1ccc(/C=C/C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F07 compound treatment 97760.0 8630.0 0.33 77480.0 6900.0 0.26 0.4199 0.9919 3082134 TimTec1_001525 Nc1nnc(CCN2C(=O)S/C(=C/c3ccccc3)/C2=O)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F08 compound treatment 103840.0 14700.0 0.57 89480.0 18900.0 0.71 0.9051 0.9942 1022021 TimTec1_001526 CC1(C)OC2C(CO)OC(C2O1)n3cnc4c(O)ncnc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F09 compound treatment 93320.0 4190.0 0.16 71800.0 1220.0 0.05 0.1473 0.8719 3210659 TimTec1_001527 OC(=O)COc1ccccc1/C=N/N2CCN(Cc3ccc(Cl)cc3)CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F10 compound treatment 85440.0 -3690.0 -0.14 84280.0 13700.0 0.51 0.2623 0.4916 3210660 TimTec1_001528 CN(C)c1ccc(cc1)C2=NN(C(C2)NC(Cc3c[nH]c4ccccc34)C(=O)O)C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F11 compound treatment 108000.0 18900.0 0.73 90360.0 19800.0 0.74 1.0426 1.0 1300950 TimTec1_001529 O=C(CN1C(=O)c2ccccc2C1=O)Nc3nnc[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F12 compound treatment 111640.0 22500.0 0.87 87560.0 17000.0 0.64 1.0682 0.988 1127108 TimTec1_001530 CCC(Sc1nc2cccc(CC)c2c(=O)n1c3ccc(OC)cc3)C(=O)NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F13 compound treatment 15480.0 -73600.0 -2.86 11000.0 -59600.0 -2.24 -3.6019 -0.9926 3082764 TimTec1_001531 Clc1nc(C#N)c(C#N)nc1C(=C2Nc3ccccc3N2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F14 compound treatment 85560.0 -3570.0 -0.14 69000.0 -1580.0 -0.06 -0.1399 -0.9287 3210661 TimTec1_001532 CC(C)C(C(=O)NN1C(=O)/C(=C/c2ccccn2)/N=C1c3ccccc3)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F15 compound treatment 8120.0 -81000.0 -3.14 6480.0 -64100.0 -2.41 -3.9238 -0.9913 3082765 TimTec1_001533 C/C=C(/C)\C(=O)OC1CC(O)(C(C)C)C2C(CC(=CCC12C)C)OC(=O)c3ccc(O)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F16 compound treatment 96080.0 6950.0 0.27 90640.0 20100.0 0.75 0.723 0.9042 1203282 TimTec1_001534 CC(O)CNC(=O)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F17 compound treatment 111120.0 22000.0 0.85 79440.0 8860.0 0.33 0.8384 0.9155 1114140 TimTec1_001535 COc1ccc(CCCC(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F18 compound treatment 93880.0 4750.0 0.18 70160.0 -424.0 -0.02 0.1191 0.6437 1082103 TimTec1_001536 Fc1ccc(NC(=S)Nc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F19 compound treatment 112760.0 23600.0 0.92 83040.0 12500.0 0.47 0.979 0.9511 1119735 TimTec1_001537 COc1ccc2[nH]cc(CCNC(=O)c3ccco3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F20 compound treatment 103280.0 14200.0 0.55 77080.0 6500.0 0.24 0.5607 0.9332 3210662 TimTec1_001538 CCOC(=O)C1=C(Nc2ccccc2)OCC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F21 compound treatment 105360.0 16200.0 0.63 78960.0 8380.0 0.31 0.6677 0.9485 3082768 TimTec1_001539 CC(C)NCC(O)COc1ccc(/C=C/c2cc(C)no2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F22 compound treatment 40160.0 -49000.0 -1.9 34120.0 -36500.0 -1.37 -2.3112 -0.987 3210663 TimTec1_001540 O=C1C(/C(=N/c2ccccc2)/c3ccccc13)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F23 mock treatment 91000.0 1870.0 0.07 74040.0 3460.0 0.13 0.1431 0.9625 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 F24 mock treatment 96200.0 7070.0 0.27 63960.0 -6620.0 -0.25 0.0183 0.0493 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G01 compound treatment 69560.0 -19600.0 -0.76 32720.0 -37900.0 -1.42 -1.5417 -0.9569 3210787 TimTec1_001541 CC1=C(NC(=S)NC(=O)c2ccccc2)NCc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G02 compound treatment 60200.0 -28900.0 -1.12 26200.0 -44400.0 -1.67 -1.9716 -0.9815 3082771 TimTec1_001542 N#C/C(=C\c1ccccc1/C=C(\C#N)/c2ccc3OCOc3c2)/c4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G03 compound treatment 85640.0 -3490.0 -0.14 55160.0 -15400.0 -0.58 -0.505 -0.8495 3210788 TimTec1_001543 OC(=O)CC1N=Cc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G04 compound treatment 88800.0 -328.0 -0.01 53040.0 -17500.0 -0.66 -0.4746 -0.7206 3210789 TimTec1_001544 C1Oc2ccc(/C=C/C=N/c3ccc(cc3)N4CCOCC4)cc2O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G05 compound treatment 91000.0 1870.0 0.07 66520.0 -4060.0 -0.15 -0.0565 -0.3343 1707466 TimTec1_001545 CN1CCN(CC(O)COc2ccccc2OCc3nc(C)no3)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G06 compound treatment 81920.0 -7210.0 -0.28 62720.0 -7860.0 -0.3 -0.4064 -0.9996 3210790 TimTec1_001546 CC1=C(Oc2ccccc2N1)C(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G07 compound treatment 87840.0 -1290.0 -0.05 71560.0 976.0 0.04 -0.0094 -0.152 1121781 TimTec1_001547 Cc1ccc(C)n1c2ccc(cc2)C(=O)OCC(=O)c3c(C)c(C)cc(C)c3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G08 compound treatment 84480.0 -4650.0 -0.18 69920.0 -664.0 -0.02 -0.1451 -0.7972 1240166 TimTec1_001548 Nc1[nH]c(=S)sc1C(=O)Nc2nccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G09 compound treatment 82880.0 -6250.0 -0.24 66720.0 -3860.0 -0.15 -0.2739 -0.9698 3082775 TimTec1_001549 Brc1ccc(cc1)C2OCC(=S)N2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G10 compound treatment 82440.0 -6690.0 -0.26 72040.0 1460.0 0.05 -0.1448 -0.5462 1301555 TimTec1_001550 CC(C)N(CCC#N)C(=O)c1c[nH]c2ccccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G11 compound treatment 87720.0 -1410.0 -0.05 66640.0 -3940.0 -0.15 -0.1433 -0.9082 1162047 TimTec1_001551 OC(=O)c1ccccc1C(=O)Nc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G12 compound treatment 7640.0 -81500.0 -3.16 6240.0 -64300.0 -2.41 -3.9433 -0.9912 1376806 TimTec1_001552 Cc1ccc(C)c(c1)C2C3CCCC=C3C(=C(N)C2(C#N)C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G13 compound treatment 75640.0 -13500.0 -0.52 62280.0 -8300.0 -0.31 -0.5904 -0.9693 1912519 TimTec1_001553 CN(C)Cc1cc(/C=N/C2CCCCC2)c(S)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G14 compound treatment 18000.0 -71100.0 -2.76 13200.0 -57400.0 -2.15 -3.4744 -0.9925 1339047 TimTec1_001554 CCc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3C(=O)CC(C)(C)CC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G15 compound treatment 82880.0 -6250.0 -0.24 73640.0 3060.0 0.11 -0.0903 -0.3367 3082839 TimTec1_001555 CCc1cc2cc(sc2s1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G16 compound treatment 90080.0 953.0 0.04 82080.0 11500.0 0.43 0.3312 0.7649 3210791 TimTec1_001556 Nc1nonc1OCCNc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G17 compound treatment 92800.0 3670.0 0.14 77480.0 6900.0 0.26 0.2838 0.9605 1225048 TimTec1_001557 CC(=O)Nc1nonc1NC2=CC(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G18 compound treatment 90920.0 1790.0 0.07 75360.0 4780.0 0.18 0.1759 0.915 1004952 TimTec1_001558 OC(c1nc2ccccc2[nH]1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G19 compound treatment 101480.0 12400.0 0.48 73000.0 2420.0 0.09 0.403 0.8262 1382010 TimTec1_001559 CCOc1ccc(OCC)c(CC2OC(=NC2=O)c3ccccc3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G20 compound treatment 74080.0 -15000.0 -0.58 53280.0 -17300.0 -0.65 -0.8721 -0.9986 3082843 TimTec1_001560 COc1ccc(/C=C(/C#N)\c2ccc(Cl)cc2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G21 compound treatment 70960.0 -18200.0 -0.7 36480.0 -34100.0 -1.28 -1.4035 -0.9605 1449158 TimTec1_001561 Brc1cccc(c1)C(CC(=O)c2ccccc2)C(C#N)C(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G22 compound treatment 61200.0 -27900.0 -1.08 55560.0 -15000.0 -0.56 -1.1649 -0.9537 1173213 TimTec1_001562 Clc1ccc(Cl)c(OCC(=O)NCc2ccccc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G23 mock treatment 92240.0 3110.0 0.12 76800.0 6220.0 0.23 0.2504 0.953 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 G24 mock treatment 89040.0 -87.5 0.0 75320.0 4740.0 0.18 0.1233 0.6935 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H01 compound treatment 81400.0 -7730.0 -0.3 72360.0 1780.0 0.07 -0.1649 -0.5368 3210792 TimTec1_001563 CN12CCCCC2C(COc3ccccc3Br)CCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H02 compound treatment 5640.0 -83500.0 -3.24 4040.0 -66500.0 -2.5 -4.0566 -0.9917 3082846 TimTec1_001564 Cc1ccc(cc1)C2=NNC3(CCOC(C)(C)C3)S2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H03 compound treatment 98040.0 8910.0 0.35 88360.0 17800.0 0.67 0.7163 0.9532 3210793 TimTec1_001565 Clc1ccccc1/C=N/C2CCS(=O)(=O)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H04 compound treatment 102240.0 13100.0 0.51 80160.0 9580.0 0.36 0.6139 0.9855 1272351 TimTec1_001566 CC(C)(C)c1ccc2OCCOCCOCCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H05 compound treatment 105000.0 15900.0 0.62 89480.0 18900.0 0.71 0.937 0.9975 3210794 TimTec1_001567 c1nn(c2ccccc2)c3ncn4nnnc4c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H06 compound treatment 111480.0 22400.0 0.87 87720.0 17100.0 0.64 1.068 0.9892 3082850 TimTec1_001568 COc1cccc(/C=C/C(=O)O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H07 compound treatment 91240.0 2110.0 0.08 79400.0 8820.0 0.33 0.2919 0.8564 3210795 TimTec1_001569 COc1ccc(cc1OC)C2=N/C(=C/c3c(C)nn(c3N4CCCCC4)c5ccccc5)/C(=O)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H08 compound treatment 95160.0 6030.0 0.23 78760.0 8180.0 0.31 0.3825 0.9911 3210796 TimTec1_001570 Cn1c(=O)c(C/2=NNC(=O)\C2=C/c3c[nH]c4ccccc34)c(O)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H09 compound treatment 33120.0 -56000.0 -2.17 14400.0 -56200.0 -2.11 -3.0277 -0.9999 1574162 TimTec1_001571 CCc1cc(c2n[nH]c(C)c2c3nc4ccccc4n3C)c(O)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H10 compound treatment 104920.0 15800.0 0.61 83600.0 13000.0 0.49 0.7787 0.9937 1654421 TimTec1_001572 CS(=O)(=O)N(Cc1ccc(cc1)C(=O)O)c2cccc(Cl)c2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H11 compound treatment 104960.0 15800.0 0.61 84280.0 13700.0 0.51 0.7979 0.9961 1562719 TimTec1_001573 O=C(CCN1C(=O)c2ccccc2C1=O)Nc3nnc[nH]3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H12 compound treatment 45080.0 -44000.0 -1.71 32800.0 -37800.0 -1.42 -2.2112 -0.9957 3210797 TimTec1_001574 Clc1ccc(cc1)N(C(=O)Nc2ccccc2Br)C3=NCCS3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H13 compound treatment 110400.0 21300.0 0.83 80680.0 10100.0 0.38 0.8516 0.9376 1779116 TimTec1_001575 CCOC(=O)CCc1n[nH]c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H14 compound treatment 100360.0 11200.0 0.44 81200.0 10600.0 0.4 0.5899 0.999 3210798 TimTec1_001576 CC(=O)OC1C(OC2C(OC(=O)C)C(=O)OC12)n3ccc(=O)[nH]c3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H15 compound treatment 9080.0 -80000.0 -3.11 29920.0 -40700.0 -1.53 -3.2753 -0.9465 3082856 TimTec1_001577 CC(C)C1C(O)C/C(=C/CC/C(=C/C1O)/C)/C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H16 compound treatment 106880.0 17800.0 0.69 88240.0 17700.0 0.66 0.9556 0.9998 1079739 TimTec1_001578 CS(=O)(=O)c1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H17 compound treatment 94560.0 5430.0 0.21 84800.0 14200.0 0.53 0.5263 0.9175 1036359 TimTec1_001579 Cc1ccc(CCCC(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H18 compound treatment 113040.0 23900.0 0.93 77600.0 7020.0 0.26 0.8423 0.8733 1014539 TimTec1_001580 S=C(Nc1ccccc1)N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H19 compound treatment 97160.0 8030.0 0.31 72280.0 1700.0 0.06 0.2654 0.8343 1593359 TimTec1_001581 Cc1ccc(cc1)c2nc3sc4C(=O)CC(C)(C)Cc4n3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H20 compound treatment 95440.0 6310.0 0.24 78720.0 8140.0 0.31 0.3891 0.994 1240459 TimTec1_001582 CCOC(=O)C1C(=O)CN(C1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H21 compound treatment 87120.0 -2010.0 -0.08 74440.0 3860.0 0.14 0.0473 0.2876 3082920 TimTec1_001583 CC12CCCCC2N(CCC(=O)N)c3ccccc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H22 compound treatment 91920.0 2790.0 0.11 74840.0 4260.0 0.16 0.1896 0.9821 1468638 TimTec1_001584 O=C1c2ccccc2C(=O)C1(Nc3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H23 mock treatment 102600.0 13500.0 0.52 78160.0 7580.0 0.28 0.5707 0.959 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 H24 mock treatment 71360.0 -17800.0 -0.69 69440.0 -1140.0 -0.04 -0.5178 -0.7497 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I01 compound treatment 59320.0 -29800.0 -1.16 33600.0 -37000.0 -1.39 -1.7993 -0.9959 1500758 TimTec1_001585 CCC(=O)NC1CC2C(OC1=O)c3cccc(C)c3NC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I02 compound treatment 26960.0 -62200.0 -2.41 14200.0 -56400.0 -2.12 -3.202 -0.9979 3082924 TimTec1_001586 CC1CCC/C(=C\c2ccc3OCOc3c2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I03 compound treatment 81080.0 -8050.0 -0.31 68680.0 -1900.0 -0.07 -0.2713 -0.847 3210799 TimTec1_001587 COC(=O)C1(C)NC2(CCCCC2)Cc3ccccc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I04 compound treatment 38160.0 -51000.0 -1.98 34320.0 -36300.0 -1.36 -2.3607 -0.9834 1512799 TimTec1_001588 CC(C)(C)C1CCc2c(C1)sc3NC(NC(=O)c23)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I05 compound treatment 89320.0 193.0 0.01 71040.0 456.0 0.02 0.0174 0.9308 1550718 TimTec1_001589 Cc1noc(COc2ccccc2OCC(=O)N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I06 compound treatment 89080.0 -47.5 0.0 68720.0 -1860.0 -0.07 -0.0508 -0.7255 3082927 TimTec1_001590 Cc1[nH]c(=O)n(c(=O)c1C)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I07 compound treatment 80120.0 -9010.0 -0.35 73040.0 2460.0 0.09 -0.1819 -0.5034 1716137 TimTec1_001591 CS(=O)(=O)Nc1cc(NS(=O)(=O)C)cc(c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I08 compound treatment 75800.0 -13300.0 -0.52 65600.0 -4980.0 -0.19 -0.4979 -0.9055 1611777 TimTec1_001592 COc1ccc(NC(=O)c2sc(=S)[nH]c2N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I09 compound treatment 45720.0 -43400.0 -1.68 41000.0 -29600.0 -1.11 -1.976 -0.9796 3210800 TimTec1_001593 Cc1ccc(cc1)C(=O)/N=c\2/cccc[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I10 compound treatment 79240.0 -9890.0 -0.38 66240.0 -4340.0 -0.16 -0.3866 -0.9273 1119826 TimTec1_001594 O=C(N1CCCCC1)c2c[nH]c3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I11 compound treatment 88200.0 -928.0 -0.04 65720.0 -4860.0 -0.18 -0.1545 -0.8305 1603574 TimTec1_001595 Cc1sc(N)c(C(=O)N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I12 compound treatment 73040.0 -16100.0 -0.62 64720.0 -5860.0 -0.22 -0.597 -0.902 1363974 TimTec1_001596 COC(=O)C1(C#N)C(C(N2C1C=Cc3ccccc23)C(=O)c4ccccc4)c5ccc(C)cc5C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I13 compound treatment 85880.0 -3250.0 -0.13 64040.0 -6540.0 -0.25 -0.2628 -0.9519 1916807 TimTec1_001597 CCS(=O)(=O)c1ccsc1S(=O)(=O)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I14 compound treatment 26680.0 -62400.0 -2.42 21080.0 -49500.0 -1.86 -3.0271 -0.9914 3082931 TimTec1_001598 NC1=C(C#N)C2=CCCCC2C(c3cccs3)C1(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I15 compound treatment 79600.0 -9530.0 -0.37 65280.0 -5300.0 -0.2 -0.4022 -0.9578 1914041 TimTec1_001599 CSc1sc(SC)c(CO)c1CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I16 compound treatment 84880.0 -4250.0 -0.16 75960.0 5380.0 0.2 0.0261 0.1004 3082933 TimTec1_001600 CC(C)(Oc1ccccc1Cl)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I17 compound treatment 86080.0 -3050.0 -0.12 76880.0 6300.0 0.24 0.0835 0.3159 1737803 TimTec1_001601 CC(=O)Nc1nonc1Nc2cc(C)nn2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I18 compound treatment 89320.0 193.0 0.01 74400.0 3820.0 0.14 0.1066 0.743 3082935 TimTec1_001602 COc1ccccc1C(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I19 compound treatment 96680.0 7550.0 0.29 75640.0 5060.0 0.19 0.3414 0.9779 1115158 TimTec1_001603 Cc1cc(C)c(C)c(C(=O)O)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I20 compound treatment 100880.0 11800.0 0.46 73360.0 2780.0 0.1 0.3961 0.8469 3210920 TimTec1_001604 CCNC(=S)Nc1ccc(OC)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I21 compound treatment 81880.0 -7250.0 -0.28 73280.0 2700.0 0.1 -0.1273 -0.4259 3082938 TimTec1_001605 Clc1ccc(/C(=C\c2ccc3OCOc3c2)/C#N)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I22 compound treatment 93360.0 4230.0 0.16 75720.0 5140.0 0.19 0.2524 0.9968 1045982 TimTec1_001606 NC(=O)NS(=O)(=O)c1ccc(N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I23 mock treatment 93280.0 4150.0 0.16 73800.0 3220.0 0.12 0.1993 0.9899 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 I24 mock treatment 73640.0 -15500.0 -0.6 68280.0 -2300.0 -0.09 -0.4861 -0.8006 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J01 compound treatment 3600.0 -85500.0 -3.32 3080.0 -67500.0 -2.53 -4.138 -0.9911 1479505 TimTec1_001607 OCCOc1c(Cl)cc(Cl)c2cccnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J02 compound treatment 93040.0 3910.0 0.15 77080.0 6500.0 0.24 0.2797 0.974 1009854 TimTec1_001608 COc1ccc(cc1)C(O)C(=O)c2ccc(OC)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J03 compound treatment 55400.0 -33700.0 -1.31 57840.0 -12700.0 -0.48 -1.2636 -0.9069 3082941 TimTec1_001609 Cc1sc(/N=C/c2ccc(Br)s2)c(C(=O)N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J04 compound treatment 100280.0 11200.0 0.43 87920.0 17300.0 0.65 0.7661 0.9804 1144212 TimTec1_001610 OC(=O)c1ccc2OCCOCCOCCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J05 compound treatment 86480.0 -2650.0 -0.1 72080.0 1500.0 0.06 -0.0329 -0.2813 3210921 TimTec1_001611 Cc1nnc(/N=C/2\S/C(=C/c3ccccc3F)/C(=O)N2CC=C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J06 compound treatment 100720.0 11600.0 0.45 83880.0 13300.0 0.5 0.6709 0.9987 1115371 TimTec1_001612 COc1ccc(cc1)C(N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J07 compound treatment 38360.0 -50800.0 -1.97 24480.0 -46100.0 -1.73 -2.6164 -0.9979 3083016 TimTec1_001613 Brc1ccc(cc1)N2C(=O)C3ON(C(/C=C/c4ccccc4)C3C2=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J08 compound treatment 94200.0 5070.0 0.2 83600.0 13000.0 0.49 0.4846 0.9201 1351925 TimTec1_001614 CCOC(=O)c1[nH]c(C(=O)O)c(C(=O)OCc2ccccc2)c1CCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J09 compound treatment 105880.0 16800.0 0.65 94400.0 23800.0 0.89 1.0917 0.9878 3083019 TimTec1_001615 COc1cccc(/N=C/C2=C3N(CCC2)c4ccccc4C3(C)C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J10 compound treatment 81840.0 -7290.0 -0.28 76440.0 5860.0 0.22 -0.0445 -0.1243 1286584 TimTec1_001616 O=C(NCCc1c[nH]c2ccc(OCc3ccccc3)cc12)C4CCCNC4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J11 compound treatment 23040.0 -66100.0 -2.56 23560.0 -47000.0 -1.76 -3.0611 -0.9834 1208195 TimTec1_001617 NNC(=O)c1cc(n[nH]1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J12 compound treatment 102760.0 13600.0 0.53 87840.0 17300.0 0.65 0.832 0.9949 3083022 TimTec1_001618 CC(N)(Cc1ccc2OCOc2c1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J13 compound treatment 51480.0 -37600.0 -1.46 78640.0 8060.0 0.3 -0.8191 -0.5491 3210922 TimTec1_001619 CN(C)c1ccc(/C=C\2/C(=NN(C2=O)c3nnc(C)c(=O)[nH]3)C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J14 compound treatment 84160.0 -4970.0 -0.19 69160.0 -1420.0 -0.05 -0.1741 -0.8703 1414476 TimTec1_001620 Cc1ccc(NC(=O)c2cccc3-c4ccccc4C(=O)c32)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J15 compound treatment 6560.0 -82600.0 -3.2 5800.0 -64800.0 -2.43 -3.9846 -0.9907 1395626 TimTec1_001621 CC1C(=O)CCC2C(C)(COc3ccc4ccc(=O)oc4c3)CCCC12C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J16 compound treatment 85840.0 -3290.0 -0.13 77600.0 7020.0 0.26 0.096 0.3281 1361860 TimTec1_001622 CC1(C)COC(OC1)c2ccc(O)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J17 compound treatment 86560.0 -2570.0 -0.1 70880.0 296.0 0.01 -0.0626 -0.6243 3083025 TimTec1_001623 CC(=CC(=O)Nc1ccc(Cl)cc1)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J18 compound treatment 83200.0 -5930.0 -0.23 70920.0 336.0 0.01 -0.1537 -0.6673 3210923 TimTec1_001624 COc1ccccc1C(=O)N(C(C)C)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J19 compound treatment 90040.0 913.0 0.04 71880.0 1300.0 0.05 0.0594 0.9878 1015339 TimTec1_001625 OC(c1ccccc1)C(O)(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J20 compound treatment 85600.0 -3530.0 -0.14 84760.0 14200.0 0.53 0.2794 0.5086 1921357 TimTec1_001626 Brc1ccccc1C2OCC3(CO2)COC(OC3)c4ccccc4Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J21 compound treatment 24560.0 -64600.0 -2.51 21440.0 -49100.0 -1.84 -3.0757 -0.9887 3083029 TimTec1_001627 C[C@]1(CCC[C@]2(C)[C@H]3CC(O)[C@](C)(C=C)C=C3CC[C@@H]12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J22 compound treatment 83200.0 -5930.0 -0.23 69240.0 -1340.0 -0.05 -0.1983 -0.8422 1236876 TimTec1_001628 OCCC1(C(=O)c2ccccc2C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J23 mock treatment 89160.0 32.5 0.0 82360.0 11800.0 0.44 0.3134 0.7091 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 J24 mock treatment 82840.0 -6290.0 -0.24 71800.0 1220.0 0.05 -0.1402 -0.565 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K01 compound treatment 3720.0 -85400.0 -3.31 9640.0 -60900.0 -2.29 -3.9606 -0.9836 1634606 TimTec1_001629 CCn1c(=O)c2C(=Nc3cc(C)ccc3Oc2c4ccccc14)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K02 compound treatment 23040.0 -66100.0 -2.56 23560.0 -47000.0 -1.76 -3.0611 -0.9834 3083031 TimTec1_001630 COc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K03 compound treatment 61680.0 -27400.0 -1.06 48160.0 -22400.0 -0.84 -1.3482 -0.9932 3210924 TimTec1_001631 COc1ccc(cc1)C2CC(=NC(=N)N2)c3cc(OC)cc(OC)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K04 compound treatment 84400.0 -4730.0 -0.18 72760.0 2180.0 0.08 -0.0719 -0.3583 3210925 TimTec1_001632 OC(=O)c1cccc(c1)c2ccc(/C=N\n3cnnc3)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K05 compound treatment 56120.0 -33000.0 -1.28 46920.0 -23700.0 -0.89 -1.5336 -0.984 1250333 TimTec1_001633 CCOC(=O)CSc1cc(Cl)c2cccc(C)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K06 compound treatment 87160.0 -1970.0 -0.08 69440.0 -1140.0 -0.04 -0.0843 -0.9629 1029874 TimTec1_001634 CCOC(=O)C1(O)c2ccccc2-c3ccccc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K07 compound treatment 70920.0 -18200.0 -0.71 58920.0 -11700.0 -0.44 -0.8091 -0.9735 1426581 TimTec1_001635 CC(C)c1cc(NC(=O)c2ccccc2)c(C)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K08 compound treatment 72400.0 -16700.0 -0.65 64000.0 -6580.0 -0.25 -0.6337 -0.9124 1278979 TimTec1_001636 CN(C)c1ccc(NC(=O)c2sc(=S)[nH]c2N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K09 compound treatment 80800.0 -8330.0 -0.32 66800.0 -3780.0 -0.14 -0.3289 -0.9319 3083036 TimTec1_001637 OC(=O)/C=C\C(=O)N1CCN(Cc2ccc3OCOc3c2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K10 compound treatment 51680.0 -37400.0 -1.45 37800.0 -32800.0 -1.23 -1.8975 -0.9966 1138966 TimTec1_001638 O=C(NC1CCCCC1)c2c[nH]c3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K11 compound treatment 5360.0 -83800.0 -3.25 5280.0 -65300.0 -2.45 -4.0313 -0.9903 3210926 TimTec1_001639 CN(C1CCCCC1)C(=O)CCCOc2ccc(Cl)cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K12 compound treatment 34680.0 -54400.0 -2.11 27440.0 -43100.0 -1.62 -2.6388 -0.9914 1449748 TimTec1_001640 Fc1ccc(cc1)C2C(C3C=Cc4ccccc4N3C2(C#N)C#N)C(=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K13 compound treatment 80680.0 -8450.0 -0.33 67280.0 -3300.0 -0.12 -0.3194 -0.9116 3083110 TimTec1_001641 CS(=O)(=O)c1ccc(s1)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K14 compound treatment 9160.0 -80000.0 -3.1 7560.0 -63000.0 -2.37 -3.8666 -0.991 1649383 TimTec1_001642 Cc1ccc(s1)C2C3CCCC=C3C(C#N)C(N)C2(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K15 compound treatment 65920.0 -23200.0 -0.9 48200.0 -22400.0 -0.84 -1.2308 -0.9994 3083113 TimTec1_001643 CC1(C)C(c2nc(no2)c3ccc(Br)cc3)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K16 compound treatment 7040.0 -82100.0 -3.19 6120.0 -64500.0 -2.42 -3.9629 -0.9908 1072463 TimTec1_001644 Oc1ccc(cc1)C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K17 compound treatment 86640.0 -2490.0 -0.1 68000.0 -2580.0 -0.1 -0.1368 -1.0 3083115 TimTec1_001645 COc1cc(/C=N/c2nonc2NC(=O)C)ccc1OC(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K18 compound treatment 85520.0 -3610.0 -0.14 70120.0 -464.0 -0.02 -0.1113 -0.789 1266444 TimTec1_001646 OC(=O)c1ccc(COc2ccccc2)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K19 compound treatment 36160.0 -53000.0 -2.06 31760.0 -38800.0 -1.46 -2.4836 -0.9858 1199220 TimTec1_001647 COc1ccc(cc1)C2C(C(=O)N)C2(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K20 compound treatment 90560.0 1430.0 0.06 68280.0 -2300.0 -0.09 -0.0218 -0.2124 3083117 TimTec1_001648 CCNC(=S)Nc1c(C)cccc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K21 compound treatment 82880.0 -6250.0 -0.24 72920.0 2340.0 0.09 -0.1094 -0.4244 3210927 TimTec1_001649 O=C/1/C(=C/c2cccc3OCOc32)/CCC\C1=C/c4cccc5OCOc54 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K22 compound treatment 84520.0 -4610.0 -0.18 72440.0 1860.0 0.07 -0.0771 -0.4021 1204849 TimTec1_001650 Oc1ccc2c(=O)c(coc2c1CN3CCCCC3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K23 mock treatment 93600.0 4470.0 0.17 79360.0 8780.0 0.33 0.3556 0.9552 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 K24 mock treatment 70240.0 -18900.0 -0.73 66680.0 -3900.0 -0.15 -0.6218 -0.832 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L01 compound treatment 69920.0 -19200.0 -0.75 67200.0 -3380.0 -0.13 -0.6168 -0.8158 1427041 TimTec1_001651 C(Cn1c2ccccc2c3ccccc13)c4nc5ccccc5[nH]4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L02 compound treatment 91440.0 2310.0 0.09 78920.0 8340.0 0.31 0.2847 0.8746 1045556 TimTec1_001652 COc1ccc2[n+]([O-])cccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L03 compound treatment 77560.0 -11600.0 -0.45 81080.0 10500.0 0.39 -0.0388 -0.065 3210928 TimTec1_001653 O=C(N1CCN(CC1)C2=NC(=O)/C(=C/c3cccs3)/S2)c4cc5ccccc5oc4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L04 compound treatment 90080.0 953.0 0.04 83080.0 12500.0 0.47 0.3578 0.7605 3083122 TimTec1_001654 COc1ccc(/C=C/C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L05 compound treatment 10800.0 -78300.0 -3.04 12000.0 -58600.0 -2.2 -3.7037 -0.9874 1566626 TimTec1_001655 Fc1ccc(cc1)C(CC(=O)c2cccs2)SCc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L06 compound treatment 96640.0 7510.0 0.29 85680.0 15100.0 0.57 0.6068 0.9523 1449697 TimTec1_001656 CC1Cc2cc(OCC(=O)O)ccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L07 compound treatment 86480.0 -2650.0 -0.1 76920.0 6340.0 0.24 0.0955 0.3687 3083124 TimTec1_001657 NC1=Cc2ccccc2CN1c3ccccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L08 compound treatment 97440.0 8310.0 0.32 81200.0 10600.0 0.4 0.5098 0.9945 3210929 TimTec1_001658 COc1ccc(cc1)N2CC(=O)N(/N=C/c3ccccc3C(=O)O)C2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L09 compound treatment 74760.0 -14400.0 -0.56 66760.0 -3820.0 -0.14 -0.4957 -0.8611 1667441 TimTec1_001659 NC(=O)c1ccccc1NC(=O)C2COc3ccccc3O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L10 compound treatment 5320.0 -83800.0 -3.25 5160.0 -65400.0 -2.46 -4.0356 -0.9904 1921446 TimTec1_001660 CC1=CC(=O)N(CCc2c[nH]c3ccc(OCc4ccccc4)cc23)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L11 compound treatment 85440.0 -3690.0 -0.14 78320.0 7740.0 0.29 0.1041 0.3217 1703270 TimTec1_001661 Nc1c(C#N)c2nc(C#N)c(C#N)nc2n1Cc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L12 compound treatment 4680.0 -84400.0 -3.28 4440.0 -66100.0 -2.48 -4.0723 -0.9906 1414477 TimTec1_001662 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCc2c[nH]c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L13 compound treatment 39520.0 -49600.0 -1.92 13000.0 -57600.0 -2.16 -2.8892 -0.9983 1436746 TimTec1_001663 Nc1c(C#N)c2nc(C#N)c(C#N)nc2n1CCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L14 compound treatment 88120.0 -1010.0 -0.04 75840.0 5260.0 0.2 0.1119 0.5562 1148985 TimTec1_001664 CCCCC1(SCCS1)c2cc(O)cc(O)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L15 compound treatment 86280.0 -2850.0 -0.11 72560.0 1980.0 0.07 -0.0257 -0.1929 3083129 TimTec1_001665 Nc1cccc(c1)C2=NCCN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L16 compound treatment 73480.0 -15600.0 -0.61 73960.0 3380.0 0.13 -0.3397 -0.5477 3211052 TimTec1_001666 CNC(=S)Nc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L17 compound treatment 78760.0 -10400.0 -0.4 72320.0 1740.0 0.07 -0.2384 -0.5849 3083131 TimTec1_001667 Cc1nc2ccc(Cl)cc2n1CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L18 compound treatment 6560.0 -82600.0 -3.2 7280.0 -63300.0 -2.38 -3.9453 -0.9892 1188527 TimTec1_001668 CN1CCCc2cc(ccc12)c3ccnc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L19 compound treatment 85680.0 -3450.0 -0.13 72320.0 1740.0 0.07 -0.0485 -0.326 3211053 TimTec1_001669 CC(C)/C=c\1/[nH]c(=O)/c(=C/c2ccccc2)/[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L20 compound treatment 87720.0 -1410.0 -0.05 76680.0 6100.0 0.23 0.1232 0.5236 3083134 TimTec1_001670 CCOC(=O)c1sc(NC(=O)C)c(C#N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L21 compound treatment 62360.0 -26800.0 -1.04 72040.0 1460.0 0.05 -0.6957 -0.669 3211054 TimTec1_001671 CC[C@H]1[C@@H]2OC(=O)[C@@H](C)[C@@H]2[C@H]3C[C@@H]([C@@H]4C[C@H](C)C(=O)O4)N5CCCC[C@H]1[C@H]35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L22 compound treatment 39120.0 -50000.0 -1.94 46640.0 -23900.0 -0.9 -2.0074 -0.9388 1341798 TimTec1_001672 O=C(Nc1ccccc1)OCC2(C(=O)c3ccccc3C2=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L23 mock treatment 80280.0 -8850.0 -0.34 76440.0 5860.0 0.22 -0.0873 -0.2142 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 L24 mock treatment 73280.0 -15800.0 -0.61 61800.0 -8780.0 -0.33 -0.6679 -0.9573 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M01 compound treatment 61440.0 -27700.0 -1.07 62080.0 -8500.0 -0.32 -0.9853 -0.8792 3083213 TimTec1_001673 C[C@@]1(CCC[C@@]2(C)[C@H]1CCc3ccc(O)cc32)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M02 compound treatment 62760.0 -26400.0 -1.02 63840.0 -6740.0 -0.25 -0.9024 -0.8562 3211055 TimTec1_001674 Clc1ccc(cc1)C(CC(=O)c2ccc(Br)cc2)C3CCCCC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M03 compound treatment 4600.0 -84500.0 -3.28 5560.0 -65000.0 -2.44 -4.0448 -0.9894 3083215 TimTec1_001675 COc1ccc2CCC3[C@@](C)(CO)CCC[C@]3(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M04 compound treatment 61800.0 -27300.0 -1.06 63800.0 -6780.0 -0.25 -0.9298 -0.8527 3211056 TimTec1_001676 COc1cc(/C=N\n2nnnc2N)cc(Cl)c1OCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M05 compound treatment 78440.0 -10700.0 -0.41 69640.0 -944.0 -0.04 -0.3183 -0.7647 1459549 TimTec1_001677 C=CCCN1C[C@@H]2CC(C1)c3cccc(=O)n3C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M06 compound treatment 74400.0 -14700.0 -0.57 63440.0 -7140.0 -0.27 -0.5937 -0.9405 1091851 TimTec1_001678 CC1=C(SCCO1)C(=O)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M07 compound treatment 48880.0 -40200.0 -1.56 64120.0 -6460.0 -0.24 -1.2758 -0.8073 3083218 TimTec1_001679 OCn1nc(oc1=S)c2ccc(Cl)cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M08 compound treatment 41800.0 -47300.0 -1.84 37360.0 -33200.0 -1.25 -2.1802 -0.9822 3211058 TimTec1_001680 CN(C)c1ccc(cc1)N/2CC(=O)S\C2=N\C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M09 compound treatment 69280.0 -19800.0 -0.77 60320.0 -10300.0 -0.39 -0.8169 -0.9487 1163310 TimTec1_001681 CN(C(=O)CSc1ccccc1C(=O)O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M10 compound treatment 4360.0 -84800.0 -3.29 5080.0 -65500.0 -2.46 -4.0641 -0.9897 1289766 TimTec1_001682 Cc1ccccc1NC(=O)c2c[nH]c3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M11 compound treatment 11600.0 -77500.0 -3.01 13240.0 -57300.0 -2.15 -3.6489 -0.9865 3211059 TimTec1_001683 O=C/1ON=C(\C1=C\C=C\c2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M12 compound treatment 11800.0 -77300.0 -3.0 5920.0 -64700.0 -2.43 -3.8377 -0.9945 1227323 TimTec1_001684 O=C(C1C(c2cccnc2)C(C#N)(C#N)C3C=Cc4ccccc4N13)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M13 compound treatment 60480.0 -28600.0 -1.11 52240.0 -18300.0 -0.69 -1.2728 -0.9735 1914043 TimTec1_001685 CCSc1sc(CN(C)C)cc1/C=N/O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M14 compound treatment 26920.0 -62200.0 -2.41 21920.0 -48700.0 -1.83 -2.9982 -0.9905 1340838 TimTec1_001686 CCOC(=O)C1=C(N)Oc2[nH]nc(C)c2C1c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M15 compound treatment 83520.0 -5610.0 -0.22 59920.0 -10700.0 -0.4 -0.4369 -0.959 1362482 TimTec1_001687 Nc1nonc1NC(=O)CSc2ncccc2C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M16 compound treatment 69480.0 -19600.0 -0.76 71600.0 1020.0 0.04 -0.5121 -0.6709 1375046 TimTec1_001688 NNC(=O)CSCc1ccc(Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M17 compound treatment 84040.0 -5090.0 -0.2 66400.0 -4180.0 -0.16 -0.2506 -0.9936 1460899 TimTec1_001689 CC(=O)Nc1nonc1N2CCCC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M18 compound treatment 70920.0 -18200.0 -0.71 68040.0 -2540.0 -0.1 -0.567 -0.7954 1065783 TimTec1_001690 CNC(=S)Nc1ccc(C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M19 compound treatment 75400.0 -13700.0 -0.53 66320.0 -4260.0 -0.16 -0.4898 -0.8807 1042406 TimTec1_001691 Clc1ccc(NC(=O)NC2CCCCC2)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M20 compound treatment 74120.0 -15000.0 -0.58 71240.0 656.0 0.02 -0.3943 -0.6766 1082102 TimTec1_001692 COc1ccc(NC(=S)Nc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M21 compound treatment 9720.0 -79400.0 -3.08 11280.0 -59300.0 -2.23 -3.7525 -0.9873 3211060 TimTec1_001693 CN1C/C(=C\c2ccccc2C)/C(=O)\C(=C\c3ccccc3C)\C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M22 compound treatment 37480.0 -51600.0 -2.0 65360.0 -5220.0 -0.2 -1.5556 -0.7726 3083226 TimTec1_001694 O=C(/C(=C\1/NC(=O)c2ccccc2N1)/C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M23 mock treatment 82960.0 -6170.0 -0.24 75280.0 4700.0 0.18 -0.0446 -0.15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 M24 mock treatment 79920.0 -9210.0 -0.36 67560.0 -3020.0 -0.11 -0.3329 -0.888 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N01 compound treatment 86080.0 -3050.0 -0.12 73240.0 2660.0 0.1 -0.0131 -0.0848 1397605 TimTec1_001695 Cc1ccc(cc1)N(C2CCS(=O)(=O)C2)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N02 compound treatment 59240.0 -29900.0 -1.16 75160.0 4580.0 0.17 -0.6985 -0.5959 1024491 TimTec1_001696 COC(=O)c1ccc(=O)oc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N03 compound treatment 48960.0 -40200.0 -1.56 55120.0 -15500.0 -0.58 -1.5124 -0.9094 3211061 TimTec1_001697 O=C(CCCN1C(=O)S/C(=C/c2ccccc2)/C1=S)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N04 compound treatment 66720.0 -22400.0 -0.87 80680.0 10100.0 0.38 -0.3468 -0.3657 3083229 TimTec1_001698 Brc1cccc(c1)C(=O)C2=CC3Cc4ccccc4C3C=C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N05 compound treatment 84000.0 -5130.0 -0.2 77480.0 6900.0 0.26 0.0423 0.1297 1440003 TimTec1_001699 CCc1cc(c2n[nH]c(CCC(=O)O)c2c3nc4ccccc4n3C)c(O)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N06 compound treatment 94000.0 4870.0 0.19 80120.0 9540.0 0.36 0.3868 0.9555 3083231 TimTec1_001700 OC(=O)C1(SCCCS1)C2CCC3OCOC3C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N07 compound treatment 64480.0 -24600.0 -0.96 77280.0 6700.0 0.25 -0.4985 -0.5042 1108575 TimTec1_001701 C[N+](=Cc1ccc(C#N)cc1)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N08 compound treatment 73560.0 -15600.0 -0.6 72720.0 2140.0 0.08 -0.3704 -0.6079 1363444 TimTec1_001702 OC(CN1C(=O)c2ccccc2C1=O)CN3CCN(CC3)c4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N09 compound treatment 25360.0 -63800.0 -2.47 25000.0 -45600.0 -1.71 -2.9593 -0.9838 1864240 TimTec1_001703 COc1cc(/C=C(\C#N)/c2ccc(Cl)cc2)ccc1OC(=O)C3COc4ccccc4O3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N10 compound treatment 71800.0 -17300.0 -0.67 70080.0 -504.0 -0.02 -0.4888 -0.7267 3082142 TimTec1_001704 CC(=O)O/C(=C\c1cn(C(=O)C)c2ccccc12)/C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N11 compound treatment 3920.0 -85200.0 -3.31 5120.0 -65500.0 -2.46 -4.0751 -0.9893 1722000 TimTec1_001705 Cc1cccc(c1)N2C(=O)c3sc4nccc(=O)n4c3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N12 compound treatment 5200.0 -83900.0 -3.26 4520.0 -66100.0 -2.48 -4.0559 -0.991 1517994 TimTec1_001706 Cc1c[nH]c2cccc(OCC(O)CN3CCN(CC3)C(c4ccccc4)c5ccccc5)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N13 compound treatment 87000.0 -2130.0 -0.08 69640.0 -944.0 -0.04 -0.0834 -0.9286 3082144 TimTec1_001707 Fc1ccc(NC(=O)CSc2nnc3ccccn23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N14 compound treatment 87440.0 -1690.0 -0.07 63880.0 -6700.0 -0.25 -0.2242 -0.8624 1606324 TimTec1_001708 CN(C)c1nc2ccc(OCCN3CCOCC3)cc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N15 compound treatment 82200.0 -6930.0 -0.27 76320.0 5740.0 0.22 -0.0378 -0.1098 3082146 TimTec1_001709 CC(CC(=O)O)n1ccnc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N16 compound treatment 70480.0 -18600.0 -0.72 71840.0 1260.0 0.05 -0.4783 -0.6596 3211063 TimTec1_001710 CCNC(=S)Nc1ccc(F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N17 compound treatment 80080.0 -9050.0 -0.35 78480.0 7900.0 0.3 -0.0387 -0.0842 3082148 TimTec1_001711 C(CSc1nc2ccccc2o1)Sc3nc4ccccc4o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N18 compound treatment 59760.0 -29400.0 -1.14 59120.0 -11500.0 -0.43 -1.11 -0.9113 1722403 TimTec1_001712 OC(OCC1Cc2ccccc2O1)C3Cc4ccccc4O3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N19 compound treatment 79080.0 -10000.0 -0.39 73560.0 2980.0 0.11 -0.1967 -0.485 3211064 TimTec1_001713 COc1ccc(/C=c/2\[nH]c(=O)\c(=C/c3ccc(OC)cc3)\[nH]c2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N20 compound treatment 5240.0 -83900.0 -3.25 5200.0 -65400.0 -2.45 -4.0367 -0.9903 1707203 TimTec1_001714 Cc1cccc(Nc2nc3nonc3nc2Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N21 compound treatment 76800.0 -12300.0 -0.48 76760.0 6180.0 0.23 -0.1743 -0.3279 3211065 TimTec1_001715 CC(C)(C)C1(O)C=C(O)C(=O)N1c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N22 compound treatment 70360.0 -18800.0 -0.73 69280.0 -1300.0 -0.05 -0.5495 -0.7529 1565579 TimTec1_001716 O=C(OCCC1(C(=O)c2ccccc2C1=O)c3ccccc3)c4cc5ccccc5oc4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N23 mock treatment 76040.0 -13100.0 -0.51 71080.0 496.0 0.02 -0.3459 -0.6807 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 N24 mock treatment 69560.0 -19600.0 -0.76 67720.0 -2860.0 -0.11 -0.6129 -0.7992 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O01 compound treatment 45600.0 -43500.0 -1.69 42240.0 -28300.0 -1.06 -1.9464 -0.9752 3211066 TimTec1_001717 CC1=C(C)C2C(=NC(=NC2=O)c3ccc(o3)c4ccc(cc4)C(=O)O)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O02 compound treatment 41720.0 -47400.0 -1.84 21200.0 -49400.0 -1.85 -2.6113 -1.0 3082153 TimTec1_001718 CCOC(=O)c1[nH]c(C)c(CC(C)C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O03 compound treatment 33320.0 -55800.0 -2.17 20560.0 -50000.0 -1.88 -2.8587 -0.9975 1487341 TimTec1_001719 COc1ccc(NC(c2ccc(C)cc2)n3ncc4c(=O)n(C)c5ccccc5c34)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O04 compound treatment 31960.0 -57200.0 -2.22 46440.0 -24100.0 -0.91 -2.2092 -0.922 3082155 TimTec1_001720 Cc1sc2NC(NC(=O)c2c1C)/C=C/c3ccc4OCOc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O05 compound treatment 69920.0 -19200.0 -0.75 59280.0 -11300.0 -0.42 -0.827 -0.9643 3211067 TimTec1_001721 CC[C@H]1CN2CCC3(C2C[C@@H]1/C(=C\OC)/C(=O)OC)C(=O)Nc4ccccc43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O06 compound treatment 70560.0 -18600.0 -0.72 86960.0 16400.0 0.61 -0.0748 -0.079 1300191 TimTec1_001722 C(Nc1ncnc2nc[nH]c12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O07 compound treatment 33000.0 -56100.0 -2.18 50280.0 -20300.0 -0.76 -2.0787 -0.901 3211068 TimTec1_001723 Cc1nn(c(C)c1/N=C/c2c(O)ccc3ccccc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O08 compound treatment 38160.0 -51000.0 -1.98 63880.0 -6700.0 -0.25 -1.5763 -0.7907 1782754 TimTec1_001724 OC(=O)c1c[nH]c2ccccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O09 compound treatment 44080.0 -45000.0 -1.75 60520.0 -10100.0 -0.38 -1.503 -0.8405 1165165 TimTec1_001725 C=CCn1nnnc1SCc2cccc(CSc3nnnn3CC=C)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O10 compound treatment 57880.0 -31200.0 -1.21 61240.0 -9340.0 -0.35 -1.1053 -0.8757 1284834 TimTec1_001726 CCc1ccccc1NC(=O)c2c[nH]c3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O11 compound treatment 83800.0 -5330.0 -0.21 64120.0 -6460.0 -0.24 -0.3177 -0.9968 3209092 TimTec1_001727 OC(=O)c1ccc(N/C=C/2\C(=O)ON=C2c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O12 compound treatment 74760.0 -14400.0 -0.56 62200.0 -8380.0 -0.31 -0.6167 -0.9634 1145898 TimTec1_001728 Nc1nc2CCCCCc2c(c1C#N)c3cccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O13 compound treatment 76120.0 -13000.0 -0.5 63680.0 -6900.0 -0.26 -0.5401 -0.952 3209093 TimTec1_001729 Cc1cc(C(=O)O)c(s1)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O14 compound treatment 69800.0 -19300.0 -0.75 62320.0 -8260.0 -0.31 -0.7496 -0.9237 1667092 TimTec1_001730 COc1ccc(cc1)c2c[nH]c(=N)s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O15 compound treatment 68680.0 -20400.0 -0.79 57400.0 -13200.0 -0.49 -0.9109 -0.9742 1602686 TimTec1_001731 Nc1nonc1NC(=O)CSC2=NCCS2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O16 compound treatment 70000.0 -19100.0 -0.74 67920.0 -2660.0 -0.1 -0.5955 -0.7952 1216965 TimTec1_001732 COc1ccc(cc1OC)S(=O)(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O17 compound treatment 78720.0 -10400.0 -0.4 66720.0 -3860.0 -0.15 -0.3881 -0.9045 3209094 TimTec1_001733 CC(=O)Nc1nonc1Nc2csc(CC#N)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O18 compound treatment 58800.0 -30300.0 -1.18 61320.0 -9260.0 -0.35 -1.0779 -0.8785 3082865 TimTec1_001734 Cc1cccc(C)c1NS(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O19 compound treatment 4160.0 -85000.0 -3.3 4920.0 -65700.0 -2.46 -4.0738 -0.9897 3209095 TimTec1_001735 OC(=O)Nc1cc(Cl)cc(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O20 compound treatment 3160.0 -86000.0 -3.34 7160.0 -63400.0 -2.38 -4.0418 -0.9863 3082867 TimTec1_001736 OC(=O)c1ccc(/N=C/c2ccc(o2)c3ccc(Cl)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O21 compound treatment 4520.0 -84600.0 -3.28 5920.0 -64700.0 -2.43 -4.0374 -0.989 1913174 TimTec1_001737 CN1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O22 compound treatment 62800.0 -26300.0 -1.02 70960.0 376.0 0.01 -0.7123 -0.6973 1594528 TimTec1_001738 NC(=O)c1ccc(OC2CSC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O23 mock treatment 91520.0 2390.0 0.09 75680.0 5100.0 0.19 0.2009 0.9449 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 O24 mock treatment 78480.0 -10600.0 -0.41 73440.0 2860.0 0.11 -0.2163 -0.5068 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P01 compound treatment 82600.0 -6530.0 -0.25 73280.0 2700.0 0.1 -0.1075 -0.3943 1562676 TimTec1_001739 S=c1oc(Cc2ccccc2)nn1CN3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P02 compound treatment 86920.0 -2210.0 -0.09 74240.0 3660.0 0.14 0.0365 0.2254 1066227 TimTec1_001740 CC(=O)Nc1nc(C)cs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P03 compound treatment 56680.0 -32400.0 -1.26 72200.0 1620.0 0.06 -0.8473 -0.6723 3209096 TimTec1_001741 Cc1cc(C(=O)CSc2nnc3ccccn23)c(C)n1c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P04 compound treatment 80800.0 -8330.0 -0.32 72960.0 2380.0 0.09 -0.1654 -0.4935 1472764 TimTec1_001742 OCCNC(=O)c1ccc2OCCOCCOCCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P05 compound treatment 71040.0 -18100.0 -0.7 65080.0 -5500.0 -0.21 -0.6423 -0.878 1707455 TimTec1_001743 C(N1CCCc2ccccc12)c3cn4ccccc4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P06 compound treatment 2800.0 -86300.0 -3.35 3440.0 -67100.0 -2.52 -4.1504 -0.9902 1631427 TimTec1_001744 COc1ccc2c(CCC3=C(C)C(=O)CCC32C)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P07 compound treatment 2240.0 -86900.0 -3.37 8800.0 -61800.0 -2.32 -4.0235 -0.9833 1684686 TimTec1_001745 N1C(Nc2cccc3cccc1c23)c4ccncc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P08 compound treatment 4720.0 -84400.0 -3.28 6520.0 -64100.0 -2.4 -4.016 -0.9885 1244779 TimTec1_001746 C(OCc1ccccc1)C(CSc2ccccc2)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P09 compound treatment 2360.0 -86800.0 -3.37 11840.0 -58700.0 -2.2 -3.9395 -0.9789 3082946 TimTec1_001747 Clc1ccccc1/C=C/C(=O)Nc2nnc[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P10 compound treatment 7760.0 -81400.0 -3.16 25880.0 -44700.0 -1.68 -3.4188 -0.9562 3209097 TimTec1_001748 O=C/1OC(=N\C1=C/c2c[nH]c3ccccc23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P11 compound treatment 3400.0 -85700.0 -3.33 4280.0 -66300.0 -2.49 -4.1116 -0.9898 1718471 TimTec1_001749 CCCc1cc(=O)n2c3C(=O)N(Cc4ccccc4)C(=O)c3sc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P12 compound treatment 65880.0 -23200.0 -0.9 55640.0 -14900.0 -0.56 -1.0344 -0.9739 1434439 TimTec1_001750 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P13 compound treatment 76560.0 -12600.0 -0.49 68080.0 -2500.0 -0.09 -0.4112 -0.8281 3209098 TimTec1_001751 Cc1nnc(C)n1/N=C/C=C\c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P14 compound treatment 72040.0 -17100.0 -0.66 72480.0 1900.0 0.07 -0.4185 -0.6276 1284591 TimTec1_001752 CS(=O)(=O)Cc1ccc(Oc2ccc(NS(=O)(=O)C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P15 compound treatment 6320.0 -82800.0 -3.21 5720.0 -64900.0 -2.43 -3.9933 -0.9906 1689423 TimTec1_001753 COc1cc-2c(CC3N(C)CCc4c(OC)c(OC)c(OC)c2c34)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P16 compound treatment 77800.0 -11300.0 -0.44 70520.0 -63.8 0.0 -0.3125 -0.7109 3082952 TimTec1_001754 CCNC(=S)N1CCOCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P17 compound treatment 69600.0 -19500.0 -0.76 63480.0 -7100.0 -0.27 -0.7243 -0.9017 1735540 TimTec1_001755 CCCCn1c(=O)oc2cc(Br)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P18 compound treatment 3720.0 -85400.0 -3.31 3520.0 -67100.0 -2.52 -4.123 -0.9908 3209099 TimTec1_001756 FC(F)(F)c1cccc(NC(=O)CSc2cccc3cccnc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P19 compound treatment 74680.0 -14400.0 -0.56 68680.0 -1900.0 -0.07 -0.4469 -0.7908 3082954 TimTec1_001757 CCN1CC(=O)N(C1=S)c2ccccc2OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P20 compound treatment 66360.0 -22800.0 -0.88 65640.0 -4940.0 -0.19 -0.7558 -0.8374 1412266 TimTec1_001758 CC(=O)n1c2ccc(C)cc2c3nc4ccccc4nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P21 compound treatment 67240.0 -21900.0 -0.85 69640.0 -944.0 -0.04 -0.6255 -0.736 3209100 TimTec1_001759 Cc1cn(C2CC(NC(=O)C(C)(C)C)C(CO)O2)c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P22 compound treatment 68240.0 -20900.0 -0.81 62640.0 -7940.0 -0.3 -0.7839 -0.9078 1065752 TimTec1_001760 O=C1C(=Cc2c[nH]c3ccccc23)C(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P23 mock treatment 79320.0 -9810.0 -0.38 74520.0 3940.0 0.15 -0.1646 -0.4033 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2067 P24 mock treatment 76760.0 -12400.0 -0.48 67720.0 -2860.0 -0.11 -0.4153 -0.8446 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A01 compound treatment 77760.0 -2470.0 -0.1 11480.0 -37300.0 -1.4 -1.0584 -0.7537 1440335 TimTec1_002465 COc1ccc2N(C(=O)CN3C(=O)CCC3=O)C(C)(C)C=C(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A02 compound treatment 78880.0 -1350.0 -0.05 25320.0 -23500.0 -0.88 -0.6604 -0.7478 3210671 TimTec1_002466 Oc1ccccc1/C=N/c2ccc(cc2)C(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A03 compound treatment 87040.0 6810.0 0.26 31880.0 -16900.0 -0.64 -0.2624 -0.3814 1235611 TimTec1_002467 CCSc1nc2ccc(NC(=O)c3ccccc3C(=O)O)cc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A04 compound treatment 61600.0 -18600.0 -0.72 8520.0 -40300.0 -1.51 -1.5804 -0.9429 3210672 TimTec1_002468 CC(NC(=O)/C=C/c1cccc2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A05 compound treatment 83840.0 3610.0 0.14 48560.0 -248.0 -0.01 0.0924 0.6587 3210673 TimTec1_002469 C[S+](C)c1c(O)n(CCc2ccc(F)cc2)c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A06 compound treatment 72200.0 -8030.0 -0.31 56840.0 8030.0 0.3 -0.0072 -0.0165 3083610 TimTec1_002470 COC(=O)COc1c(C)cc(Br)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A07 compound treatment 49040.0 -31200.0 -1.21 35400.0 -13400.0 -0.5 -1.2116 -0.9244 3210674 TimTec1_002471 Oc1cc(=O)n(n2c(=O)cc(O)n(c3ccccc3)c2=S)c(=S)n1c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A08 compound treatment 33640.0 -46600.0 -1.81 13040.0 -35800.0 -1.34 -2.2275 -0.9893 1664815 TimTec1_002472 Cn1c(Cl)c(CN)c2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A09 compound treatment 15800.0 -64400.0 -2.5 9640.0 -39200.0 -1.47 -2.8072 -0.968 3083613 TimTec1_002473 CCOC(=O)c1cc(C(=O)c2ccc(Cl)cc2)n3c1ccc4ccccc43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A10 compound treatment 40760.0 -39500.0 -1.53 24520.0 -24300.0 -0.91 -1.7275 -0.9693 3210675 TimTec1_002474 COc1ccc2ccccc2c1/C=N/c3ccc(C)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A11 compound treatment 45080.0 -35200.0 -1.36 36680.0 -12100.0 -0.46 -1.2863 -0.8946 3210676 TimTec1_002475 Cc1ccc(cc1)N2C(=O)NC(=O)/C(=C/NCCC3=CCCCC3)/C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A12 compound treatment 62880.0 -17400.0 -0.67 49800.0 993.0 0.04 -0.4497 -0.667 3083616 TimTec1_002476 CCn1c2ccccc2c3cc(/C=N/c4cccc(C#N)c4)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A13 compound treatment 87960.0 7730.0 0.3 62680.0 13900.0 0.52 0.5802 0.9657 1250862 TimTec1_002477 CC(N1C(=O)c2ccccc2C1=O)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A14 compound treatment 94600.0 14400.0 0.56 70720.0 21900.0 0.82 0.9758 0.9821 1382898 TimTec1_002478 NC(=O)c1cccc(c1)N2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A15 compound treatment 18480.0 -61800.0 -2.4 47720.0 -1090.0 -0.04 -1.7231 -0.719 3210677 TimTec1_002479 Cc1ccc(C(=O)c2ccn(n2)C(=O)c3ccc(F)cc3)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A16 compound treatment 99640.0 19400.0 0.75 118360.0 69600.0 2.61 2.3783 0.8754 3083617 TimTec1_002480 COc1cc(OC)c(/C=N/O)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A17 compound treatment 68160.0 -12100.0 -0.47 103240.0 54400.0 2.04 1.1134 0.5312 3210678 TimTec1_002481 Clc1cc(NC(=O)C2CC2)ccc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A18 compound treatment 27200.0 -53000.0 -2.06 48880.0 72.5 0.0 -1.453 -0.7062 3210679 TimTec1_002482 Cc1c(Cc2ccccc2)sc(/N=C/c3ccc4ccccc4c3)c1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A19 compound treatment 21320.0 -58900.0 -2.29 43880.0 -4930.0 -0.18 -1.7471 -0.7618 3083619 TimTec1_002483 CCOc1ccc(/N=C\2/C(=O)Nc3ccc(C)c(Br)c23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A20 compound treatment 3400.0 -76800.0 -2.98 5240.0 -43600.0 -1.64 -3.2642 -0.96 1596328 TimTec1_002484 Oc1ccc(cc1)C2N(CCN2c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A21 compound treatment 35840.0 -44400.0 -1.72 37120.0 -11700.0 -0.44 -1.5281 -0.8597 3210680 TimTec1_002485 CCN(CC)c1ccc(/C=N/c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A22 compound treatment 64000.0 -16200.0 -0.63 44480.0 -4330.0 -0.16 -0.5602 -0.8613 3210681 TimTec1_002486 CCc1c(O)nc(SCC(=O)NC(C)(C)C)n(c2ccc(F)cc2)c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A23 mock treatment 91880.0 11600.0 0.45 52400.0 3590.0 0.13 0.4149 0.8797 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 A24 mock treatment 100400.0 20200.0 0.78 44160.0 -4650.0 -0.17 0.43 0.5363 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B01 compound treatment 106400.0 26200.0 1.02 84560.0 35800.0 1.34 1.6668 0.9905 3210682 TimTec1_002487 CCc1n[nH]c(=O)n1Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B02 compound treatment 116920.0 36700.0 1.42 110640.0 61800.0 2.32 2.6476 0.9725 1134528 TimTec1_002488 Clc1cccc(NC(=O)NCCN2Cc3ccccc3C2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B03 compound treatment 112040.0 31800.0 1.23 130840.0 82000.0 3.08 3.0498 0.9194 1695505 TimTec1_002489 COC(=O)c1ccccc1NC(=O)c2c(C)nc3ccccn23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B04 compound treatment 87760.0 7530.0 0.29 141000.0 92200.0 3.46 2.6533 0.7641 1061354 TimTec1_002490 OC(=O)CCCN1C(=O)c2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B05 compound treatment 128720.0 48500.0 1.88 152320.0 104000.0 3.89 4.0774 0.9446 3210683 TimTec1_002491 C/C(=N\n1cnnc1)/c2ccc(cc2)n3cnnn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B06 compound treatment 101120.0 20900.0 0.81 143840.0 95000.0 3.57 3.0952 0.8462 1660739 TimTec1_002492 Clc1cccc(NC(=O)C2CN(Cc3ccccc3)C(=O)C2)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B07 compound treatment 77520.0 -2710.0 -0.11 110240.0 61400.0 2.31 1.556 0.6741 1742832 TimTec1_002493 CCOC(=O)N(C)CCc1cc2OCOc2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B08 compound treatment 69440.0 -10800.0 -0.42 117760.0 69000.0 2.59 1.5339 0.5851 3083672 TimTec1_002494 Cc1ccc2nc(=S)nc(c3ccccc3)n2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B09 compound treatment 63440.0 -16800.0 -0.65 121800.0 73000.0 2.74 1.4765 0.5243 3210684 TimTec1_002495 N=C1S/C(=C\2/C(=O)NN(C2=O)c3ccccc3)/SC=C1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B10 compound treatment 89160.0 8930.0 0.35 123440.0 74600.0 2.8 2.2256 0.7886 1574189 TimTec1_002496 COc1ccc(cc1)C(C#N)N2N=C(C)CC2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B11 compound treatment 62600.0 -17600.0 -0.68 116920.0 68100.0 2.56 1.3239 0.5003 3083674 TimTec1_002497 O=C1NN=C(CC(N1)c2ccco2)c3cc4ccccc4oc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B12 compound treatment 130960.0 50700.0 1.97 131040.0 82200.0 3.09 3.5742 0.9764 1539134 TimTec1_002498 Sc1nc2cc(ccc2s1)C(=O)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B13 compound treatment 136080.0 55800.0 2.17 168880.0 120000.0 4.51 4.7189 0.9437 3083676 TimTec1_002499 OCc1cn(nn1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B14 compound treatment 108080.0 27800.0 1.08 137840.0 89000.0 3.34 3.1269 0.8904 1459359 TimTec1_002500 Clc1ccc(CCN2CC(CC2=O)C(=O)OCC(=O)c3ccc(Cl)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B15 compound treatment 86040.0 5810.0 0.23 143520.0 94700.0 3.55 2.6729 0.7504 1402941 TimTec1_002501 CN(C)Cc1nnnn1CCn2nnnc2CN(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B16 compound treatment 45240.0 -35000.0 -1.36 109960.0 61200.0 2.3 0.6629 0.2486 3210801 TimTec1_002502 Cc1ccc(C(=O)COC(=O)c2ccc(cc2)n3cnnn3)c(C)c1.Cc1ccc(C)c(c1)C(=O)COC(=O)c2ccc(cc2)n3cnnn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B17 compound treatment 62000.0 -18200.0 -0.71 134680.0 85900.0 3.22 1.7788 0.5391 3083678 TimTec1_002503 COC(=O)c1c(C)c(C)[nH]c(=O)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B18 compound treatment 49960.0 -30300.0 -1.17 103440.0 54600.0 2.05 0.6194 0.2621 1544714 TimTec1_002504 CCOc1ccc(c2ccccc12)S(=O)(=O)NCC3CCCO3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B19 compound treatment 86880.0 6650.0 0.26 121880.0 73100.0 2.74 2.1217 0.7702 1721791 TimTec1_002505 CC(C)C(C)(NC(=O)c1cccnc1Oc2ccc(Cl)cc2)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B20 compound treatment 89440.0 9210.0 0.36 94360.0 45600.0 1.71 1.4616 0.8368 1358324 TimTec1_002506 CCOC(=O)CN(C)c1nc(cs1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B21 compound treatment 68840.0 -11400.0 -0.44 83240.0 34400.0 1.29 0.6013 0.4402 1160634 TimTec1_002507 O=C(NCc1nc(cs1)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B22 compound treatment 54600.0 -25600.0 -0.99 62520.0 13700.0 0.51 -0.3393 -0.303 1033354 TimTec1_002508 O=C(Nc1cccc(c1)C2=NCCN2)Nc3cccc(c3)C4=NCCN4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B23 mock treatment 81560.0 1330.0 0.05 72360.0 23600.0 0.88 0.6615 0.7471 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 B24 mock treatment 85520.0 5290.0 0.21 55760.0 6950.0 0.26 0.3296 0.9929 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C01 compound treatment 8640.0 -71600.0 -2.78 2920.0 -45900.0 -1.72 -3.182 -0.9736 1317591 TimTec1_002509 Brc1ccccc1OCc2ccc(o2)C(=O)Nc3ccc(I)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C02 compound treatment 10440.0 -69800.0 -2.71 6560.0 -42200.0 -1.59 -3.036 -0.9675 3210802 TimTec1_002510 Oc1ccc(Br)cc1/C=N/CCC2=CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C03 compound treatment 63440.0 -16800.0 -0.65 42720.0 -6090.0 -0.23 -0.6222 -0.9013 3083683 TimTec1_002511 COC(=O)c1ccc(cc1)n2nnnc2SCC(=O)NC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C04 compound treatment 26760.0 -53500.0 -2.07 18000.0 -30800.0 -1.16 -2.2846 -0.9619 3210803 TimTec1_002512 O=C(Nc1nccs1)/C=C/c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C05 compound treatment 106920.0 26700.0 1.04 48840.0 32.5 0.0 0.7331 0.7079 1542712 TimTec1_002513 CCOc1ccc(NC(=O)CSc2nnnn2CC(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C06 compound treatment 108680.0 28400.0 1.1 53240.0 4430.0 0.17 0.8982 0.8046 3083686 TimTec1_002514 COc1cc(/C=N/O)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C07 compound treatment 39120.0 -41100.0 -1.6 33240.0 -15600.0 -0.58 -1.5411 -0.9072 1452827 TimTec1_002515 O=C(CSc1nc2scc(c3cccs3)c2c(=O)n1c4ccccc4)NCc5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C08 compound treatment 67200.0 -13000.0 -0.51 25960.0 -22800.0 -0.86 -0.9639 -0.9683 1593834 TimTec1_002516 OCc1ccccc1CN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C09 compound treatment 57520.0 -22700.0 -0.88 28840.0 -20000.0 -0.75 -1.153 -0.9967 1361213 TimTec1_002517 COC(=O)c1cc(c(C)o1)c2cncnc2c3ccc(OC)c(C)c3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C10 compound treatment 59040.0 -21200.0 -0.82 31400.0 -17400.0 -0.65 -1.0434 -0.9935 3210804 TimTec1_002518 COc1ccc2ccccc2c1/C=N/c3cccc(CO)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C11 compound treatment 77040.0 -3190.0 -0.12 32080.0 -16700.0 -0.63 -0.5315 -0.8306 1240365 TimTec1_002519 Clc1ccc(cc1)C(=O)Nc2ccccc2C(=O)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C12 compound treatment 132560.0 52300.0 2.03 54360.0 5550.0 0.21 1.583 0.7756 3083730 TimTec1_002520 Cc1cc(C)cc(/N=C/c2ccc(C#N)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C13 compound treatment 32560.0 -47700.0 -1.85 23560.0 -25200.0 -0.95 -1.9779 -0.9517 3083732 TimTec1_002521 N/C(=C\C(=O)c1ccc(Br)cc1)/C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C14 compound treatment 135440.0 55200.0 2.14 88800.0 40000.0 1.5 2.5761 0.9849 3210805 TimTec1_002522 COc1cc(/C=N/c2cc(C)ccc2C)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C15 compound treatment 107320.0 27100.0 1.05 90920.0 42100.0 1.58 1.8608 0.9804 3210806 TimTec1_002523 CN1CCN(CC1)C(=O)c2ccccc2NC(=O)c3ccc(F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C16 compound treatment 50960.0 -29300.0 -1.14 69800.0 21000.0 0.79 -0.246 -0.1779 1638681 TimTec1_002524 Ic1ccc(NC(=O)c2ccccc2C(=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C17 compound treatment 9920.0 -70300.0 -2.73 15680.0 -33100.0 -1.24 -2.8082 -0.9367 3083735 TimTec1_002525 Cc1ccsc1/C=N/c2c(C)cc(C)cc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C18 compound treatment 57280.0 -23000.0 -0.89 96320.0 47500.0 1.78 0.6312 0.3167 3210807 TimTec1_002526 CC(=O)N/C(=C/c1ccccc1)/C(=O)N2CCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C19 compound treatment 22640.0 -57600.0 -2.23 33560.0 -15200.0 -0.57 -1.9847 -0.8604 3210808 TimTec1_002527 CCn1c2ccccc2c3cc(/C=N/c4ccc(OC)cc4)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C20 compound treatment 74720.0 -5510.0 -0.21 140640.0 91800.0 3.45 2.2859 0.662 3083737 TimTec1_002528 COc1cc(NC(=O)c2cccc(Br)c2)nc(OC)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C21 compound treatment 40800.0 -39400.0 -1.53 49040.0 233.0 0.01 -1.0757 -0.7031 3210809 TimTec1_002529 COc1cc(/C=N/c2ccc(Br)c(Cl)c2)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C22 compound treatment 96320.0 16100.0 0.62 129880.0 81100.0 3.04 2.593 0.8348 3083739 TimTec1_002530 CC1=C(CNC(=S)N1)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C23 mock treatment 79800.0 -431.0 -0.02 70720.0 21900.0 0.82 0.5697 0.6926 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 C24 mock treatment 82160.0 1930.0 0.07 46480.0 -2330.0 -0.09 -0.0089 -0.077 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D01 compound treatment 68440.0 -11800.0 -0.46 59280.0 10500.0 0.39 -0.0456 -0.0756 3210810 TimTec1_002531 CCCc1nncn1NC(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D02 compound treatment 50640.0 -29600.0 -1.15 61120.0 12300.0 0.46 -0.4851 -0.392 1545647 TimTec1_002532 CCC1=NCC(=O)Nc2ccc(Cl)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D03 compound treatment 74040.0 -6190.0 -0.24 70840.0 22000.0 0.83 0.4149 0.4818 3210811 TimTec1_002533 O=C/1Nc2ccccc2\C1=N\N3C(=O)CC(=O)CC3=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D04 compound treatment 120080.0 39800.0 1.55 114120.0 65300.0 2.45 2.8266 0.9753 1629795 TimTec1_002534 O=C(COc1ccccc1C#N)Nc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D05 compound treatment 81840.0 1610.0 0.06 111120.0 62300.0 2.34 1.6978 0.7257 1595606 TimTec1_002535 Cc1cc(C)n(CNc2c(C)n(C)n(c3ccccc3)c2=O)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D06 compound treatment 117840.0 37600.0 1.46 102720.0 53900.0 2.02 2.4626 0.9871 1277145 TimTec1_002536 CC1=NN(C(=O)Cc2ccccc2)C(C)(C)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D07 compound treatment 18480.0 -61800.0 -2.4 15120.0 -33700.0 -1.26 -2.5882 -0.9554 3210812 TimTec1_002537 CC(=O)OC1=NN(N(=C1)O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D08 compound treatment 19640.0 -60600.0 -2.35 27160.0 -21600.0 -0.81 -2.2369 -0.8993 3210813 TimTec1_002538 CCCc1ccc(OCCNC(=O)c2ccc3ccccc3n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D09 compound treatment 45040.0 -35200.0 -1.37 42080.0 -6730.0 -0.25 -1.144 -0.8239 1241793 TimTec1_002539 CCOC(=O)Cn1c2CCC(Cc2sc1=N)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D10 compound treatment 101960.0 21700.0 0.84 104160.0 55400.0 2.08 2.0651 0.9211 1587827 TimTec1_002540 OC(=O)CC1(CC(=O)NCc2ccc3OCOc3c2)CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D11 compound treatment 116840.0 36600.0 1.42 115640.0 66800.0 2.51 2.7781 0.9637 3083745 TimTec1_002541 Clc1ccc(CNC(=C(C#N)C#N)Nc2ccccc2)cn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D12 compound treatment 148880.0 68600.0 2.66 125840.0 77000.0 2.89 3.9278 0.9992 1378435 TimTec1_002542 CCCC(O)(CCC)C(=O)NN1CCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D13 compound treatment 69640.0 -10600.0 -0.41 78560.0 29800.0 1.12 0.499 0.4194 1537190 TimTec1_002543 CCCC(=O)n1c(=O)oc2cc(Br)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D14 compound treatment 93680.0 13400.0 0.52 83200.0 34400.0 1.29 1.2817 0.9206 3083789 TimTec1_002544 COc1ccc(C#N)c(c1)S(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D15 compound treatment 89120.0 8890.0 0.34 102920.0 54100.0 2.03 1.68 0.8155 3241 TimTec1_002545 CN1CCCN=C1/C=C/c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D16 compound treatment 53320.0 -26900.0 -1.04 91920.0 43100.0 1.62 0.4058 0.2107 3083792 TimTec1_002546 CNc1nc(Nc2ccc(OC(F)(F)F)cc2)nc(OCC(F)(F)F)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D17 compound treatment 9560.0 -70700.0 -2.74 12480.0 -36300.0 -1.36 -2.903 -0.948 1551509 TimTec1_002547 C(N1CCOCC1)c2ccc(cc2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D18 compound treatment 91520.0 11300.0 0.44 98960.0 50200.0 1.88 1.6407 0.849 3210815 TimTec1_002548 CCC1(C)OC(=O)N2CCc3ccccc3C21C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D19 compound treatment 79960.0 -271.0 -0.01 75400.0 26600.0 1.0 0.6983 0.6996 1026666 TimTec1_002549 Clc1ccccc1NC(=O)Nc2ccccc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D20 compound treatment 87800.0 7570.0 0.29 91960.0 43200.0 1.62 1.3529 0.8219 3083794 TimTec1_002550 Oc1cc(n[nH]1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D21 compound treatment 73600.0 -6630.0 -0.26 80480.0 31700.0 1.19 0.6586 0.5415 1273445 TimTec1_002551 CC(=O)Nc1cc2OCCOc2cc1C(=O)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D22 compound treatment 50120.0 -30100.0 -1.17 48560.0 -248.0 -0.01 -0.8327 -0.7127 1411171 TimTec1_002552 OCCN1CCN(CC1)S(=O)(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D23 mock treatment 84600.0 4370.0 0.17 88000.0 39200.0 1.47 1.16 0.7834 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 D24 mock treatment 74640.0 -5590.0 -0.22 50280.0 1470.0 0.06 -0.1143 -0.5107 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E01 compound treatment 56280.0 -24000.0 -0.93 4880.0 -43900.0 -1.65 -1.8229 -0.9632 1153857 TimTec1_002553 COc1ccc(NC(=S)N2CCN(C)CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E02 compound treatment 61320.0 -18900.0 -0.73 18760.0 -30000.0 -1.13 -1.3163 -0.9783 1699449 TimTec1_002554 S=C(Nc1sc2CCCc2c1C#N)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E03 compound treatment 73480.0 -6750.0 -0.26 26720.0 -22100.0 -0.83 -0.7714 -0.8873 1502764 TimTec1_002555 Cc1cc(C)n(n1)C(Nc2cc(C)ccn2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E04 compound treatment 7920.0 -72300.0 -2.81 5120.0 -43700.0 -1.64 -3.1433 -0.9673 1627110 TimTec1_002556 OCc1ccccc1CNc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E05 compound treatment 97200.0 17000.0 0.66 38120.0 -10700.0 -0.4 0.1819 0.236 1382760 TimTec1_002557 CCC(=O)Nc1nc(NC(=O)CC)c2ncn(C(=O)CC)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E06 compound treatment 107800.0 27600.0 1.07 46640.0 -2170.0 -0.08 0.6989 0.6514 1126108 TimTec1_002558 COc1ccc(CCNc2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E07 compound treatment 79680.0 -551.0 -0.02 41880.0 -6930.0 -0.26 -0.199 -0.7627 3083800 TimTec1_002559 COc1ccc(cc1)C2=C3NN=C(N)N3NN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E08 compound treatment 67720.0 -12500.0 -0.49 30760.0 -18000.0 -0.68 -0.8222 -0.9867 1594522 TimTec1_002560 CNCc1cc2ccccc2s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E09 compound treatment 70280.0 -9950.0 -0.39 38280.0 -10500.0 -0.4 -0.5524 -0.9999 3210930 TimTec1_002561 COc1ccc(c(O)c1)c2ncnc(c2c3cscn3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E10 compound treatment 42040.0 -38200.0 -1.48 25160.0 -23600.0 -0.89 -1.6754 -0.97 3083802 TimTec1_002562 CCOC(=O)c1ccc(/N=C/c2ccc3ccccc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E11 compound treatment 108680.0 28400.0 1.1 51440.0 2630.0 0.1 0.8504 0.7673 1258628 TimTec1_002563 NS(=O)(=O)c1ccc(CCNC(=O)C(Sc2ccccc2)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E12 compound treatment 129760.0 49500.0 1.92 56080.0 7270.0 0.27 1.5519 0.7995 3083804 TimTec1_002564 CCN(CC)c1ccc(/C=N/c2cc(C)cc(C)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E13 compound treatment 44040.0 -36200.0 -1.4 10120.0 -38700.0 -1.45 -2.0197 -0.9999 3210931 TimTec1_002565 Cc1ccc(O)c(c1)c2cc(no2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E14 compound treatment 112800.0 32600.0 1.26 59080.0 10300.0 0.39 1.1662 0.8827 1565284 TimTec1_002566 CN(C)c1ccc(cc1)C2N(Cc3ccccc3)CCN2Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E15 compound treatment 52280.0 -28000.0 -1.08 29000.0 -19800.0 -0.74 -1.2925 -0.983 1532411 TimTec1_002567 O=C(Nc1ccccc1)Nc2ccc(cc2)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E16 compound treatment 81960.0 1730.0 0.07 42000.0 -6810.0 -0.26 -0.1332 -0.5044 1209164 TimTec1_002568 N#Cc1ccc(cc1)C2N(CCN2c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E17 compound treatment 80640.0 409.0 0.02 68520.0 19700.0 0.74 0.5344 0.7221 1709264 TimTec1_002569 OC(c1cccs1)c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E18 compound treatment 38240.0 -42000.0 -1.63 28800.0 -20000.0 -0.75 -1.683 -0.9382 3210932 TimTec1_002570 CCn1c2ccccc2c3cc(/C=N/c4ccc(C)cc4O)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E19 compound treatment 110480.0 30200.0 1.17 80720.0 31900.0 1.2 1.6768 0.9999 3083808 TimTec1_002571 FC(F)(F)Oc1ccc(/N=C/c2ccc[nH]2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E20 compound treatment 87040.0 6810.0 0.26 66800.0 18000.0 0.68 0.6643 0.9161 1012470 TimTec1_002572 COc1ccc(CNC2CCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E21 compound treatment 53080.0 -27200.0 -1.05 47840.0 -968.0 -0.04 -0.7706 -0.731 3210933 TimTec1_002573 COC(=O)c1ccc(/N=C/c2ccc(Br)s2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E22 compound treatment 65480.0 -14800.0 -0.57 48520.0 -288.0 -0.01 -0.4123 -0.7203 1473837 TimTec1_002574 O=C(NCc1ccco1)C2CCCN2S(=O)(=O)c3ccc4ccccc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E23 mock treatment 72040.0 -8190.0 -0.32 58880.0 10100.0 0.38 0.0426 0.0862 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 E24 mock treatment 58400.0 -21800.0 -0.85 45880.0 -2930.0 -0.11 -0.6767 -0.7922 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F01 compound treatment 72080.0 -8150.0 -0.32 71960.0 23200.0 0.87 0.3908 0.4226 1161969 TimTec1_002575 CN(C)c1ccc(cc1)C2ON2[C@H]3CC[C@H](O)CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F02 compound treatment 91160.0 10900.0 0.42 74400.0 25600.0 0.96 0.979 0.9324 1195693 TimTec1_002576 COc1ccc(cc1OC)C2OC(=O)C(=C(O)C2(C)C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F03 compound treatment 41880.0 -38400.0 -1.49 45200.0 -3610.0 -0.14 -1.1479 -0.7683 3210934 TimTec1_002577 CN(C)c1ccc(/C=C(/NC(=O)c2ccccc2)\C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F04 compound treatment 100080.0 19800.0 0.77 75560.0 26800.0 1.0 1.2546 0.9914 1326441 TimTec1_002578 Nc1nonc1OCc2ccc3OCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F05 compound treatment 108840.0 28600.0 1.11 92760.0 44000.0 1.65 1.9514 0.9814 3210935 TimTec1_002579 Clc1ccc(/C=N/N2C(=O)CNC2=O)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F06 compound treatment 127400.0 47200.0 1.83 86200.0 37400.0 1.4 2.2865 0.9914 3083845 TimTec1_002580 CCOC(=O)c1cc(C)[nH]c(=S)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F07 compound treatment 106560.0 26300.0 1.02 86120.0 37300.0 1.4 1.7126 0.988 3210936 TimTec1_002581 CCOC(=O)C1C(C)NC(=O)N=C1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F08 compound treatment 110480.0 30200.0 1.17 76560.0 27800.0 1.04 1.5664 0.9982 1507322 TimTec1_002582 COc1ccc(cc1OC)C(=O)CSc2nc(N)cc(=O)[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F09 compound treatment 105880.0 25600.0 1.0 93920.0 45100.0 1.69 1.9009 0.9679 1564107 TimTec1_002583 Oc1ccccc1SCC(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F10 compound treatment 111280.0 31000.0 1.2 90920.0 42100.0 1.58 1.9695 0.991 1190430 TimTec1_002584 OC(=O)c1ccccc1c2nnn[nH]2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F11 compound treatment 132000.0 51800.0 2.01 97440.0 48600.0 1.83 2.711 0.9989 3210937 TimTec1_002585 Cc1ccnc(NS(=O)(=O)c2ccc(/N=C/3\SCC(=O)N3CC=C)cc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F12 compound treatment 85440.0 5210.0 0.2 56080.0 7270.0 0.27 0.3359 0.9891 3210938 TimTec1_002586 COC(=O)C1=CN(Cc2ccc(Cl)cc2)C=C(C1c3cccs3)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F13 compound treatment 75640.0 -4590.0 -0.18 62520.0 13700.0 0.51 0.238 0.4369 1386655 TimTec1_002587 COc1ccc(OC)c(c1)C(=O)COc2ccccc2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F14 compound treatment 137320.0 57100.0 2.22 106000.0 57200.0 2.15 3.0841 0.9999 1502288 TimTec1_002588 Nc1nc(=O)n(CCC#N)cc1F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F15 compound treatment 87560.0 7330.0 0.28 64160.0 15400.0 0.58 0.6085 0.947 1508658 TimTec1_002589 CSC1=C(C#N)C2(CCCCC2)C3=C(CCC3)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F16 compound treatment 102640.0 22400.0 0.87 64880.0 16100.0 0.6 1.0414 0.984 1232692 TimTec1_002590 Cc1cccc(C)c1NC(=O)C(NC(=O)c2ccc(cc2)n3cnnn3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F17 compound treatment 87880.0 7650.0 0.3 79000.0 30200.0 1.13 1.0111 0.8632 3083851 TimTec1_002591 COc1ccc(Cl)cc1C(=O)NN2C(=CC(C)(C)NC2=S)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F18 compound treatment 93440.0 13200.0 0.51 71440.0 22600.0 0.85 0.963 0.9707 3210939 TimTec1_002592 FC(F)(F)C1(N=C(OC(=N1)N2CCOCC2)N3CCOCC3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F19 compound treatment 94200.0 14000.0 0.54 63400.0 14600.0 0.55 0.7705 1.0 3083853 TimTec1_002593 NC1=NC(=O)C(CC(=O)O)CS1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F20 compound treatment 28320.0 -51900.0 -2.01 20160.0 -28600.0 -1.08 -2.1845 -0.9568 1554458 TimTec1_002594 CCOC(=O)C1(CCN(CCC(=O)Nc2ccc(cc2)C(=O)OC)CC1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F21 compound treatment 78360.0 -1870.0 -0.07 75400.0 26600.0 1.0 0.6544 0.6539 1231612 TimTec1_002595 COc1ccc(cc1)C2C(C)C3(O)CC(C#N)(C(=O)N3)C2(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F22 compound treatment 61360.0 -18900.0 -0.73 55560.0 6750.0 0.25 -0.3385 -0.4369 1368021 TimTec1_002596 CC(=O)N(CCOc1ccccc1)CCOc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F23 mock treatment 87560.0 7330.0 0.28 61240.0 12400.0 0.47 0.531 0.9718 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 F24 mock treatment 55240.0 -25000.0 -0.97 48440.0 -368.0 -0.01 -0.6954 -0.7171 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G01 compound treatment 75440.0 -4790.0 -0.19 6040.0 -42800.0 -1.61 -1.2665 -0.7838 1248844 TimTec1_002597 Cc1ccc(o1)C(=O)NCC2CCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G02 compound treatment 84880.0 4650.0 0.18 21080.0 -27700.0 -1.04 -0.6083 -0.576 3210940 TimTec1_002598 S=C(Nc1ccccc1)Nc2cccc(C#N)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G03 compound treatment 87800.0 7570.0 0.29 19960.0 -28800.0 -1.08 -0.5579 -0.4973 1385961 TimTec1_002599 Cc1ccc(cc1C)C(=O)COC(=O)c2ccc(cc2)c3nnc(o3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G04 compound treatment 64560.0 -15700.0 -0.61 13800.0 -35000.0 -1.31 -1.359 -0.9387 1301988 TimTec1_002600 Brc1c(OCC(=O)NCc2ccccc2)ccc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G05 compound treatment 103120.0 22900.0 0.89 36000.0 -12800.0 -0.48 0.2881 0.2853 3210941 TimTec1_002601 O=C1CNC(=O)N1/N=C/2\C(=O)Nc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G06 compound treatment 73640.0 -6590.0 -0.26 42680.0 -6130.0 -0.23 -0.3435 -0.9986 3083899 TimTec1_002602 COc1ccc(CCNCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G07 compound treatment 87880.0 7650.0 0.3 36520.0 -12300.0 -0.46 -0.1162 -0.212 3083901 TimTec1_002603 Cc1c(C#N)c(=O)n(nc1C(=O)O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G08 compound treatment 100800.0 20600.0 0.8 28560.0 -20200.0 -0.76 0.027 0.0245 3210942 TimTec1_002604 Cn1ccnc1C(O)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G09 compound treatment 83760.0 3530.0 0.14 20880.0 -27900.0 -1.05 -0.6444 -0.6096 3210943 TimTec1_002605 CCCN1C(=O)/C(=C\2/C(=O)N(CC=C)c3ccccc23)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G10 compound treatment 107920.0 27700.0 1.07 21000.0 -27800.0 -1.04 0.0217 0.0145 3083904 TimTec1_002606 NC(=O)c1cccc(/N=C/c2ccc3ccccc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G11 compound treatment 76520.0 -3710.0 -0.14 24760.0 -24000.0 -0.9 -0.74 -0.8097 3210944 TimTec1_002607 CCOc1ccccc1/C=N/c2ccc(cc2)S(=O)(=O)N3CCc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G12 compound treatment 143680.0 63400.0 2.46 40640.0 -8170.0 -0.31 1.524 0.6143 3083906 TimTec1_002608 Cc1ccc(C)c(/N=C/c2ccc(C#N)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G13 compound treatment 19760.0 -60500.0 -2.35 8800.0 -40000.0 -1.5 -2.7208 -0.9767 3210945 TimTec1_002609 Oc1ccccc1c2cc(n(n2)c3ccccc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G14 compound treatment 92240.0 12000.0 0.47 52240.0 3430.0 0.13 0.4206 0.87 3083907 TimTec1_002610 Oc1c(Cl)cc(Cl)cc1/C=N/c2sc3CCCc3c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G15 compound treatment 110760.0 30500.0 1.18 57840.0 9030.0 0.34 1.0773 0.8744 1229191 TimTec1_002611 Nc1ccc(cc1)C(=O)N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G16 compound treatment 104080.0 23800.0 0.93 52240.0 3430.0 0.13 0.7454 0.7979 1298485 TimTec1_002612 C=CCC(CC=C)(NC(=O)c1ccccc1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G17 compound treatment 37640.0 -42600.0 -1.65 32240.0 -16600.0 -0.62 -1.6082 -0.9108 3210946 TimTec1_002613 CSc1ccc(/C=N/c2ccc(Nc3ccccc3)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G18 compound treatment 43400.0 -36800.0 -1.43 24200.0 -24600.0 -0.92 -1.6636 -0.9777 3210947 TimTec1_002614 Cc1[nH]c2ccccc2c1/C=N/c3ccc(Cl)cc3C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G19 compound treatment 89920.0 9690.0 0.38 67320.0 18500.0 0.69 0.7571 0.9584 3083909 TimTec1_002615 COC(=O)CSc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G20 compound treatment 63880.0 -16400.0 -0.63 38200.0 -10600.0 -0.4 -0.7301 -0.9748 1173404 TimTec1_002616 COc1ccc2ccccc2c1C(O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G21 compound treatment 41280.0 -39000.0 -1.51 27800.0 -21000.0 -0.79 -1.6262 -0.954 3083910 TimTec1_002617 CCN(CC)c1ccc(/N=C/c2cccs2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G22 compound treatment 65840.0 -14400.0 -0.56 70440.0 21600.0 0.81 0.1793 0.1819 3210948 TimTec1_002618 CN1C(=O)/C(=C\c2c(O)c3ccccc3n(C)c2=O)/C(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G23 mock treatment 83320.0 3090.0 0.12 55240.0 6430.0 0.24 0.2555 0.9478 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 G24 mock treatment 82120.0 1890.0 0.07 47120.0 -1690.0 -0.06 0.007 0.0726 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H01 compound treatment 105760.0 25500.0 0.99 56560.0 7750.0 0.29 0.9061 0.8777 1619414 TimTec1_002619 Cc1cc(no1)c2c(O)c3ccccc3n(C)c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H02 compound treatment 96760.0 16500.0 0.64 56000.0 7190.0 0.27 0.6444 0.9261 1650607 TimTec1_002620 CC1C(OC(=O)C2(CCCCC2)C1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H03 compound treatment 93600.0 13400.0 0.52 80800.0 32000.0 1.2 1.2158 0.9295 1490854 TimTec1_002621 O=COCC1OC(OC=O)C(Nc2ccccc2)C(OC=O)C1OC=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H04 compound treatment 62600.0 -17600.0 -0.68 50600.0 1790.0 0.07 -0.4362 -0.6345 1609235 TimTec1_002622 Fc1ccc(CSc2nc3cccnc3[nH]2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H05 compound treatment 38960.0 -41300.0 -1.6 22400.0 -26400.0 -0.99 -1.8331 -0.9734 3211069 TimTec1_002623 C/C(=N\N1C(=O)CC(=O)NC1=S)/c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H06 compound treatment 108320.0 28100.0 1.09 86720.0 37900.0 1.42 1.7768 0.9913 3083914 TimTec1_002624 CC1SC(NC1=O)c2ccc(F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H07 compound treatment 102720.0 22500.0 0.87 63280.0 14500.0 0.54 1.0011 0.974 1308303 TimTec1_002625 CCOC(=O)c1cccc(c1)C(=O)NC2=CC(=O)CC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H08 compound treatment 121440.0 41200.0 1.6 81520.0 32700.0 1.23 1.9988 0.9915 3083916 TimTec1_002626 COc1ccc(cc1)C(=O)c2nocc2C(=O)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H09 compound treatment 54560.0 -25700.0 -1.0 32400.0 -16400.0 -0.62 -1.1398 -0.9733 1428534 TimTec1_002627 O=c1oc2ccccc2cc1C3=NC(=S)NC(C3)c4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H10 compound treatment 115960.0 35700.0 1.39 88000.0 39200.0 1.47 2.0204 0.9996 1170391 TimTec1_002628 NC(=O)CN1C(=O)c2cccc3cccc1c23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H11 compound treatment 121040.0 40800.0 1.58 87720.0 38900.0 1.46 2.1523 0.9992 3211070 TimTec1_002629 S=c1nc(/N=C/c2ccco2)cc(/N=C/c3ccco3)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H12 compound treatment 119760.0 39500.0 1.53 83920.0 35100.0 1.32 2.0164 0.9971 1704493 TimTec1_002630 Cc1cc2OC(=C(C#N)C3(C(=O)N(CC(=O)O)c4ccccc43)c2c(=O)o1)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H13 compound treatment 129720.0 49500.0 1.92 89560.0 40800.0 1.53 2.4393 0.9936 1554929 TimTec1_002631 O=C(Oc1cccnc1)c2cc3ccccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H14 compound treatment 103640.0 23400.0 0.91 69680.0 20900.0 0.78 1.1962 0.9973 1212825 TimTec1_002632 Cc1[nH]c2ccccc2c1CCN3C(=O)CCC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H15 compound treatment 28120.0 -52100.0 -2.02 11400.0 -37400.0 -1.4 -2.4225 -0.9841 1243289 TimTec1_002633 COC(=O)C1=C(C)N(C(=O)C1)c2ccc(cc2)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H16 compound treatment 101880.0 21600.0 0.84 78320.0 29500.0 1.11 1.3772 0.9907 1495691 TimTec1_002634 CC(O)(C#CCN1CCCCC1)C2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H17 compound treatment 113120.0 32900.0 1.28 67640.0 18800.0 0.71 1.4021 0.9612 1405861 TimTec1_002635 CCN(CC)C(=O)CSc1nc2CCCCc2cc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H18 compound treatment 102880.0 22600.0 0.88 55840.0 7030.0 0.26 0.808 0.8806 3083985 TimTec1_002636 CCc1c(C)nc(N)nc1S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H19 compound treatment 123400.0 43200.0 1.67 76400.0 27600.0 1.04 1.9167 0.9733 1285150 TimTec1_002637 CC1(O)NC(=O)C2(C#N)C(C#N)(C#N)C21c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H20 compound treatment 101240.0 21000.0 0.82 70120.0 21300.0 0.8 1.142 1.0 1677097 TimTec1_002638 Cc1nc(C(=O)N)c(N)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H21 compound treatment 84960.0 4730.0 0.18 58040.0 9230.0 0.35 0.3748 0.9558 1163471 TimTec1_002639 COC(=O)c1ccc(NC(=O)CSc2nccn2C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H22 compound treatment 85600.0 5370.0 0.21 55440.0 6630.0 0.25 0.3233 0.9961 3083989 TimTec1_002640 Cc1cc(C)n(CNc2nccs2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H23 mock treatment 79160.0 -1070.0 -0.04 62400.0 13600.0 0.51 0.3313 0.6473 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 H24 mock treatment 58520.0 -21700.0 -0.84 33880.0 -14900.0 -0.56 -0.9918 -0.9804 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I01 compound treatment 108760.0 28500.0 1.11 3880.0 -44900.0 -1.69 -0.4096 -0.2031 1611631 TimTec1_002641 O=C(Nc1ccccc1)Nc2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I02 compound treatment 119800.0 39600.0 1.54 26960.0 -21800.0 -0.82 0.5058 0.2906 1685279 TimTec1_002642 COc1ccc(cc1I)C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I03 compound treatment 84760.0 4530.0 0.18 20040.0 -28800.0 -1.08 -0.6392 -0.5843 1725903 TimTec1_002643 CCOC(=O)C(C)Oc1ccc2oc(=O)cc(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I04 compound treatment 13920.0 -66300.0 -2.57 5000.0 -43800.0 -1.64 -2.9819 -0.9766 1725678 TimTec1_002644 Cc1ccc(NC(=O)COc2ccc3ccccc3c2Br)cc1F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I05 compound treatment 75200.0 -5030.0 -0.2 22040.0 -26800.0 -1.0 -0.8484 -0.829 3083992 TimTec1_002645 CN(C)c1ccc(/C=N/N2C(=O)CNC2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I06 compound treatment 8480.0 -71800.0 -2.78 4240.0 -44600.0 -1.67 -3.1513 -0.9703 3211071 TimTec1_002646 CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1OC(=O)C(O)C(O)C(=O)O[C@H]2C[C@H](C)CC[C@H]2C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I07 compound treatment 108280.0 28000.0 1.09 23960.0 -24800.0 -0.93 0.1101 0.0768 1159008 TimTec1_002647 O=C(CSc1ncnc2[nH]cnc12)NCCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I08 compound treatment 111440.0 31200.0 1.21 21720.0 -27100.0 -1.02 0.1374 0.0869 3211072 TimTec1_002648 Cc1ccc(/N=C/c2ccc(Br)s2)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I09 compound treatment 45120.0 -35100.0 -1.36 11360.0 -37400.0 -1.41 -1.9571 -0.9999 1275751 TimTec1_002649 Cc1cccc(c1)N(CC(=O)Nc2ccc3c(c2)oc4ccccc43)S(=O)(=O)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I10 compound treatment 55000.0 -25200.0 -0.98 19800.0 -29000.0 -1.09 -1.4621 -0.9986 3083996 TimTec1_002650 COc1ccc(/N=C/c2ccc3ccccc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I11 compound treatment 30960.0 -49300.0 -1.91 13400.0 -35400.0 -1.33 -2.2915 -0.9842 3211073 TimTec1_002651 CC(=O)Nc1ccc(cc1)c2csc(Nc3ccccc3C)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I12 compound treatment 138640.0 58400.0 2.27 29880.0 -18900.0 -0.71 1.1002 0.4632 3083998 TimTec1_002652 Cc1cccc(/C=N/c2cccc(O)c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I13 compound treatment 72640.0 -7590.0 -0.29 23560.0 -25200.0 -0.95 -0.8783 -0.8851 3083999 TimTec1_002653 O=c1n(OCc2ccccc2)c(SCc3ccccc3)nc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I14 compound treatment 105800.0 25600.0 0.99 39760.0 -9050.0 -0.34 0.4614 0.44 3211074 TimTec1_002654 Cc1ccc(/C=N/c2ccc(Oc3ccccc3)cc2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I15 compound treatment 46000.0 -34200.0 -1.33 23160.0 -25600.0 -0.96 -1.6198 -0.9875 3211075 TimTec1_002655 O=C(Nc1ccccc1)Nc2ccc(cc2)C(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I16 compound treatment 116840.0 36600.0 1.42 53520.0 4710.0 0.18 1.1295 0.7891 1270363 TimTec1_002656 Cc1ccc(cc1)S(=O)(=O)NC(CC=C)(CC=C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I17 compound treatment 97320.0 17100.0 0.66 47960.0 -848.0 -0.03 0.4464 0.6724 3211076 TimTec1_002657 N#Cc1ccc(/C=N/c2cccc3c(\N=C\c4ccc(C#N)cc4)cccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I18 compound treatment 81800.0 1570.0 0.06 50120.0 1310.0 0.05 0.0779 0.9945 3084003 TimTec1_002658 NC(=O)c1ccccc1/N=C/c2ccc(O)c(O)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I19 compound treatment 87840.0 7610.0 0.3 41720.0 -7090.0 -0.27 0.0207 0.052 3211077 TimTec1_002659 Oc1ccc(Br)cc1/C=N/Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I20 compound treatment 68080.0 -12200.0 -0.47 48320.0 -488.0 -0.02 -0.3463 -0.734 1542526 TimTec1_002660 COc1cc(CNc2ccccc2)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I21 compound treatment 93480.0 13200.0 0.51 53280.0 4470.0 0.17 0.4822 0.8917 3211078 TimTec1_002661 N#Cc1cccc(/N=C/c2ccc3OCOc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I22 compound treatment 83960.0 3730.0 0.14 70840.0 22000.0 0.83 0.687 0.8184 1646643 TimTec1_002662 CCn1c(=O)c(C(C)Nc2ccco2)c(O)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I23 mock treatment 84320.0 4090.0 0.16 50000.0 1190.0 0.04 0.1438 0.8725 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 I24 mock treatment 48840.0 -31400.0 -1.22 37600.0 -11200.0 -0.42 -1.1587 -0.8992 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J01 compound treatment 106560.0 26300.0 1.02 50200.0 1390.0 0.05 0.7593 0.7423 1132674 TimTec1_002663 CCC1=CC(=NC(C)CN1)c2c(O)c3ccccc3n(C)c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J02 compound treatment 125600.0 45400.0 1.76 45800.0 -3010.0 -0.11 1.1649 0.6604 3084072 TimTec1_002664 OC(=O)c1ccc2nsnc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J03 compound treatment 94080.0 13800.0 0.54 53440.0 4630.0 0.17 0.5029 0.8905 1532331 TimTec1_002665 Fc1ccc(cc1)N2C(=S)N=C(CC23C(=O)Nc4ccccc43)c5ccc(F)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J04 compound treatment 76680.0 -3550.0 -0.14 53000.0 4190.0 0.16 0.0138 0.0661 3084075 TimTec1_002666 FC(F)(F)c1ccc2n(Cc3ccccc3)c(=O)c(=O)[nH]c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J05 compound treatment 110920.0 30700.0 1.19 67160.0 18400.0 0.69 1.329 0.9661 1654151 TimTec1_002667 O=c1ccn(CN2CCCCC2)c(=O)n1CN3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J06 compound treatment 92920.0 12700.0 0.49 52040.0 3230.0 0.12 0.4339 0.8558 1571522 TimTec1_002668 CN1NC2(CCCCC2)N(C1=S)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J07 compound treatment 99120.0 18900.0 0.73 51400.0 2590.0 0.1 0.587 0.794 3211079 TimTec1_002669 Oc1ccccc1/C=N/c2cc(ccc2O)S(=O)(=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J08 compound treatment 93880.0 13600.0 0.53 53360.0 4550.0 0.17 0.4953 0.8901 1488051 TimTec1_002670 CC1CN(CCc2ccccc2)CCC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J09 compound treatment 118880.0 38600.0 1.5 68720.0 19900.0 0.75 1.5888 0.9483 3211080 TimTec1_002671 C/C(=N\Cc1ccccn1)/c2c(O)c3ccccc3n(c4ccccc4)c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J10 compound treatment 115400.0 35200.0 1.36 74680.0 25900.0 0.97 1.6515 0.9861 3084079 TimTec1_002672 OCCNC(=O)C1=NN=CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J11 compound treatment 129440.0 49200.0 1.91 87800.0 39000.0 1.46 2.3849 0.9914 1667994 TimTec1_002673 CC1=NN(C(=O)c2ccco2)C(O)(C1)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J12 compound treatment 129760.0 49500.0 1.92 63600.0 14800.0 0.56 1.7514 0.8756 3211081 TimTec1_002674 OC(=O)CCCNC1=NC2(CCCC2)Cc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J13 compound treatment 115320.0 35100.0 1.36 76560.0 27800.0 1.04 1.6992 0.9913 3209107 TimTec1_002675 NC(CCCNC(=N)N)C(=O)O.OC(=O)CCCC[C@H]1SC[C@H]2NC(=O)N[C@@H]12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J14 compound treatment 110760.0 30500.0 1.18 67120.0 18300.0 0.69 1.3236 0.9665 1608879 TimTec1_002676 NN(C(=O)C1CCCCC1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J15 compound treatment 117520.0 37300.0 1.45 66440.0 17600.0 0.66 1.491 0.9372 1250350 TimTec1_002677 COc1cc(NC(=O)C)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J16 compound treatment 119600.0 39400.0 1.53 57080.0 8270.0 0.31 1.2997 0.8338 1447389 TimTec1_002678 Cn1cnc2n(Cc3ccccc3)c(=O)[nH]c(=S)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J17 compound treatment 92240.0 12000.0 0.47 52080.0 3270.0 0.12 0.4163 0.864 1466505 TimTec1_002679 COCc1cc(O)n2c3ccccc3nc2c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J18 compound treatment 98320.0 18100.0 0.7 52760.0 3950.0 0.15 0.6012 0.838 1156263 TimTec1_002680 COC(=O)CC1(O)N(C(=CC1=O)c2ccc(C)cc2)c3ccccc3OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J19 compound treatment 57160.0 -23100.0 -0.9 35840.0 -13000.0 -0.49 -0.9771 -0.959 1548500 TimTec1_002681 CC1(C)CCCC(C)(C)N1OC(=O)c2ccc(N)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J20 compound treatment 20560.0 -59700.0 -2.32 14800.0 -34000.0 -1.28 -2.5397 -0.9606 3084081 TimTec1_002682 OC1(NN=C2C=Cc3ccccc3N21)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J21 compound treatment 70440.0 -9790.0 -0.38 39640.0 -9170.0 -0.34 -0.5119 -0.9988 1276203 TimTec1_002683 CNC(C)c1ccc2OCCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J22 compound treatment 77520.0 -2710.0 -0.11 47200.0 -1610.0 -0.06 -0.117 -0.9652 3084083 TimTec1_002684 C(N1CCNCC1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J23 mock treatment 92600.0 12400.0 0.48 51600.0 2790.0 0.1 0.4135 0.8417 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 J24 mock treatment 60360.0 -19900.0 -0.77 38160.0 -10600.0 -0.4 -0.8278 -0.9532 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K01 compound treatment 59480.0 -20800.0 -0.81 3760.0 -45000.0 -1.69 -1.7648 -0.9424 3209108 TimTec1_002685 COc1ccc(cc1)C(=O)CSc2nc3cc(C)ccc3cc2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K02 compound treatment 99120.0 18900.0 0.73 17440.0 -31400.0 -1.18 -0.3142 -0.2266 3084085 TimTec1_002686 CCOc1ccc(/C=N/c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K03 compound treatment 110440.0 30200.0 1.17 22080.0 -26700.0 -1.0 0.1195 0.0774 1247383 TimTec1_002687 O=C(CSc1nc2cccnc2[nH]1)NC3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K04 compound treatment 41680.0 -38600.0 -1.5 13680.0 -35100.0 -1.32 -1.9899 -0.998 3084087 TimTec1_002688 COc1cccc(/N=C/c2ccc(O)cc2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K05 compound treatment 76520.0 -3710.0 -0.14 22360.0 -26400.0 -0.99 -0.8037 -0.8013 3209109 TimTec1_002689 O=C1CNC(=O)N1/N=C/c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K06 compound treatment 87840.0 7610.0 0.3 37480.0 -11300.0 -0.43 -0.0919 -0.1775 1409322 TimTec1_002690 OCc1ccccc1CNCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K07 compound treatment 19800.0 -60400.0 -2.34 3680.0 -45100.0 -1.69 -2.8556 -0.9873 3209110 TimTec1_002691 CCOC(=O)Cc1c(C)[nH]c2c(c(C)nn2c1=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K08 compound treatment 76480.0 -3750.0 -0.15 5440.0 -43400.0 -1.63 -1.2538 -0.7673 3084090 TimTec1_002692 Cc1ccc(/N=C/c2c[nH]c3ccccc23)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K09 compound treatment 54160.0 -26100.0 -1.01 4080.0 -44700.0 -1.68 -1.9023 -0.9706 1411633 TimTec1_002693 CC(NC(=O)c1cc(oc1C)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K10 compound treatment 54320.0 -25900.0 -1.01 8640.0 -40200.0 -1.51 -1.7769 -0.9806 3084091 TimTec1_002694 NC(=O)c1ccccc1/N=C/c2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K11 compound treatment 116920.0 36700.0 1.42 30320.0 -18500.0 -0.69 0.516 0.3258 3209111 TimTec1_002695 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2cccc(c2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K12 compound treatment 101480.0 21200.0 0.82 36040.0 -12800.0 -0.48 0.2441 0.256 3084157 TimTec1_002696 Cc1cc(C)cc(/N=C/c2cccc(OCc3ccccc3)c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K13 compound treatment 115920.0 35700.0 1.38 42360.0 -6450.0 -0.24 0.808 0.5748 3084159 TimTec1_002697 COC(=O)CNC(=O)c1cc[nH]n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K14 compound treatment 95560.0 15300.0 0.59 36800.0 -12000.0 -0.45 0.1019 0.1365 1444507 TimTec1_002698 Cc1ccc(s1)C2N(CCN2c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K15 compound treatment 111960.0 31700.0 1.23 51560.0 2750.0 0.1 0.9436 0.7638 3084162 TimTec1_002699 FC(F)(F)Oc1ccc(/N=C/c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K16 compound treatment 83280.0 3050.0 0.12 33560.0 -15200.0 -0.57 -0.321 -0.5493 1914768 TimTec1_002700 C(=N/c1cccc2c(\N=C\c3ccco3)cccc12)\c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K17 compound treatment 107880.0 27600.0 1.07 53000.0 4190.0 0.16 0.8698 0.8022 3209112 TimTec1_002701 Cc1ccc2nc(sc2c1)c3ccc(NC(=O)Nc4ccccc4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K18 compound treatment 69480.0 -10800.0 -0.42 40600.0 -8210.0 -0.31 -0.5128 -0.9889 3209113 TimTec1_002702 Cc1ccc(/C=N/c2ccccc2OCc3ccccc3)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K19 compound treatment 109480.0 29200.0 1.13 47800.0 -1010.0 -0.04 0.7757 0.6832 3084165 TimTec1_002703 N#Cc1cc2CCCc2nc1SCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K20 compound treatment 42800.0 -37400.0 -1.45 24200.0 -24600.0 -0.92 -1.68 -0.9761 1504412 TimTec1_002704 Fc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K21 compound treatment 37600.0 -42600.0 -1.65 24280.0 -24500.0 -0.92 -1.8206 -0.9617 3084167 TimTec1_002705 CCOc1ccccc1/C=N/c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K22 compound treatment 60240.0 -20000.0 -0.78 33760.0 -15000.0 -0.56 -0.9478 -0.9878 3209114 TimTec1_002706 COc1cccc(c1)C(=O)N2N=C(O)C=CC2=C(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K23 mock treatment 73280.0 -6950.0 -0.27 41080.0 -7730.0 -0.29 -0.3958 -0.9993 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 K24 mock treatment 86080.0 5850.0 0.23 34400.0 -14400.0 -0.54 -0.2219 -0.3784 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L01 compound treatment 113520.0 33300.0 1.29 28320.0 -20500.0 -0.77 0.3696 0.2459 1454168 TimTec1_002707 COc1cc(OC)nc(n1)C(=O)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L02 compound treatment 127080.0 46800.0 1.82 53280.0 4470.0 0.17 1.404 0.7691 1013845 TimTec1_002708 OC(=O)C1CCN(CC1)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L03 compound treatment 52400.0 -27800.0 -1.08 29520.0 -19300.0 -0.72 -1.2754 -0.9811 3084171 TimTec1_002709 SC1=N(/N=C/2\C(=O)Nc3ccccc23)C(=O)C4C=CC=CC4=N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L04 compound treatment 84320.0 4090.0 0.16 39160.0 -9650.0 -0.36 -0.1439 -0.3639 1202182 TimTec1_002710 NC1=C(C#N)C(=C(C#N)C#N)C(O1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L05 compound treatment 98560.0 18300.0 0.71 50680.0 1870.0 0.07 0.5526 0.7732 1265429 TimTec1_002711 CC1(C)CC(=O)C(C(C2C(=O)CC(C)(C)CC2=O)c3ccc(F)cc3O)C(=O)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L06 compound treatment 113320.0 33100.0 1.28 43480.0 -5330.0 -0.2 0.7664 0.5899 3084174 TimTec1_002712 COc1ccc(cc1OC)/C(=N/O)/c2nccc3cc(OC)c(OC)cc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L07 compound treatment 87160.0 6930.0 0.27 42560.0 -6250.0 -0.23 0.0243 0.0681 1260243 TimTec1_002713 S=c1nc(c2ccco2)c3c(=S)[nH]c(=S)[nH]c3[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L08 compound treatment 110000.0 29800.0 1.16 44360.0 -4450.0 -0.17 0.6987 0.5987 1599464 TimTec1_002714 CC1CN(CCC1=O)C2CC(C)(C)NC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L09 compound treatment 113880.0 33600.0 1.31 59960.0 11200.0 0.42 1.2192 0.8892 1384770 TimTec1_002715 CN(C)c1ccc(cc1)C2OCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L10 compound treatment 117960.0 37700.0 1.46 56600.0 7790.0 0.29 1.2419 0.8319 1608667 TimTec1_002716 NC(=O)CNC(=O)c1ccc2ccccc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L11 compound treatment 10880.0 -69400.0 -2.69 3640.0 -45200.0 -1.7 -3.1014 -0.9752 3209115 TimTec1_002717 COC(=O)CNS(=O)(=O)Nc1ccc(cc1)c2nc3ccc(C)cc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L12 compound treatment 42640.0 -37600.0 -1.46 12880.0 -35900.0 -1.35 -1.9848 -0.9992 1678540 TimTec1_002718 Clc1ccc2n(CCC(=O)n3c(=O)oc4cc(Cl)ccc34)c(=O)oc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L13 compound treatment 91680.0 11400.0 0.44 49200.0 393.0 0.01 0.3245 0.7302 1920767 TimTec1_002719 Cc1cc(c2ccco2)n(n1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L14 compound treatment 118680.0 38400.0 1.49 56200.0 7390.0 0.28 1.2511 0.8245 3084178 TimTec1_002720 CCOC(=O)Cc1nnn[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L15 compound treatment 98600.0 18400.0 0.71 40480.0 -8330.0 -0.31 0.283 0.3636 3209116 TimTec1_002721 Brc1ccc(cc1)C(=S)N2CCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L16 compound treatment 109200.0 29000.0 1.12 36080.0 -12700.0 -0.48 0.457 0.3742 1354769 TimTec1_002722 CC(C)COC(=O)NCc1ccc2OCOc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L17 compound treatment 111720.0 31500.0 1.22 45320.0 -3490.0 -0.13 0.7714 0.6278 3209117 TimTec1_002723 Cc1ccc(cc1)[C@H]2[C@@H](C#N)[C@H](C#N)N3CCCN23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L18 compound treatment 99000.0 18800.0 0.73 34280.0 -14500.0 -0.55 0.1294 0.1422 71735 TimTec1_002724 COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L19 compound treatment 117120.0 36900.0 1.43 43040.0 -5770.0 -0.22 0.859 0.5934 3084252 TimTec1_002725 CC1(C)OC(=O)N(C1=C)c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L20 compound treatment 99760.0 19500.0 0.76 43720.0 -5090.0 -0.19 0.4008 0.5129 3084253 TimTec1_002726 CC(=O)N1C2CC(C=C2)C1(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L21 compound treatment 74560.0 -5670.0 -0.22 32720.0 -16100.0 -0.6 -0.5825 -0.9065 1279868 TimTec1_002727 CCc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L22 compound treatment 68960.0 -11300.0 -0.44 29880.0 -18900.0 -0.71 -0.8116 -0.9728 1355496 TimTec1_002728 Cc1ccc(CSCC(=O)Nc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L23 mock treatment 83800.0 3570.0 0.14 38960.0 -9850.0 -0.37 -0.1634 -0.4141 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 L24 mock treatment 76600.0 -3630.0 -0.14 36840.0 -12000.0 -0.45 -0.4172 -0.8863 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M01 compound treatment 85560.0 5330.0 0.21 3800.0 -45000.0 -1.69 -1.0483 -0.616 1520938 TimTec1_002729 Cn1c2ccccc2c3nn(c4ccccc4)c(=O)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M02 compound treatment 72320.0 -7910.0 -0.31 13960.0 -34800.0 -1.31 -1.1419 -0.85 3209118 TimTec1_002730 NS(=O)(=O)c1ccc(/N=C/c2c3ccccc3cc4ccccc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M03 compound treatment 7400.0 -72800.0 -2.83 2480.0 -46300.0 -1.74 -3.2277 -0.9728 3084256 TimTec1_002731 CC(C)(C)c1ccc(OCCNC(=O)c2cccc(Br)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M04 compound treatment 28200.0 -52000.0 -2.02 6280.0 -42500.0 -1.6 -2.5562 -0.9932 3209119 TimTec1_002732 O=C(Nc1cccc(C#N)c1)/C=C/c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M05 compound treatment 15240.0 -65000.0 -2.52 6200.0 -42600.0 -1.6 -2.9139 -0.9758 3084258 TimTec1_002733 Cc1ccc(cc1)N2C(SCC2=O)/C=C/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M06 compound treatment 113920.0 33700.0 1.31 27640.0 -21200.0 -0.79 0.3625 0.237 3209120 TimTec1_002734 C=CCC1(CC=C)CCCCN1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M07 compound treatment 30400.0 -49800.0 -1.93 4920.0 -43900.0 -1.65 -2.5319 -0.9968 3209121 TimTec1_002735 Cc1nc(NCc2ccco2)c3cc(sc3n1)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M08 compound treatment 60960.0 -19300.0 -0.75 9600.0 -39200.0 -1.47 -1.5693 -0.9507 3084261 TimTec1_002736 Ic1ccc(/N=C/c2ccc(C#N)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M09 compound treatment 109520.0 29300.0 1.14 12920.0 -35900.0 -1.35 -0.1489 -0.0845 3209238 TimTec1_002737 COc1ccc(OC)c(/C=c/2\sc3nnc(c4ccccc4Cl)n3c2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M10 compound treatment 51240.0 -29000.0 -1.12 15080.0 -33700.0 -1.27 -1.6905 -0.9983 3084262 TimTec1_002738 COc1ccc(/N=C/c2ccccc2OCc3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M11 compound treatment 114880.0 34600.0 1.34 33440.0 -15400.0 -0.58 0.5428 0.371 3209239 TimTec1_002739 C/C(=N/CCO)/c1c([nH]n(c2nc3ccccc3s2)c1=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M12 compound treatment 110640.0 30400.0 1.18 34560.0 -14200.0 -0.53 0.4562 0.3522 3084263 TimTec1_002740 Cc1ccccc1/C=N/c2ccccc2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M13 compound treatment 118280.0 38000.0 1.48 45920.0 -2890.0 -0.11 0.9673 0.6534 3209240 TimTec1_002741 COC(=O)N(C)c1ccccc1C(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M14 compound treatment 71320.0 -8910.0 -0.35 35640.0 -13200.0 -0.49 -0.5939 -0.9847 3084265 TimTec1_002742 CCCOC(=O)c1ccc(/N=C/c2ccc(C)s2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M15 compound treatment 127040.0 46800.0 1.82 40600.0 -8210.0 -0.31 1.0664 0.5789 1321825 TimTec1_002743 CC(Oc1ccc(Cl)cc1Cl)C(=O)NN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M16 compound treatment 105160.0 24900.0 0.97 51600.0 2790.0 0.1 0.7581 0.7792 3084267 TimTec1_002744 COc1cc(/C=N/c2ccc(cc2)C(=O)c3ccccc3)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M17 compound treatment 47680.0 -32600.0 -1.26 18040.0 -30800.0 -1.15 -1.7096 -0.999 1712191 TimTec1_002745 Cc1ccc(cc1I)C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M18 compound treatment 13000.0 -67200.0 -2.61 5640.0 -43200.0 -1.62 -2.9902 -0.9738 3209241 TimTec1_002746 CCCC(=O)c1ccc(/N=C/c2ccc(Cl)cc2Cl)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M19 compound treatment 110720.0 30500.0 1.18 45880.0 -2930.0 -0.11 0.7588 0.6387 3084269 TimTec1_002747 Brc1ccc(/C=N/c2ccccc2C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M20 compound treatment 58280.0 -22000.0 -0.85 31840.0 -17000.0 -0.64 -1.0526 -0.9897 1423653 TimTec1_002748 COc1ccc(NC(=O)c2ccc(Cn3cc(Cl)cn3)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M21 compound treatment 7760.0 -72500.0 -2.81 2840.0 -46000.0 -1.73 -3.2082 -0.9725 3084271 TimTec1_002749 Cc1nn(C(=S)N)c(O)c1C(C(C#N)C#N)c2cccc(Cl)c2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M22 compound treatment 74520.0 -5710.0 -0.22 30560.0 -18200.0 -0.68 -0.641 -0.8904 3209242 TimTec1_002750 NC(=O)Oc1ccc(I)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M23 mock treatment 84520.0 4290.0 0.17 47480.0 -1330.0 -0.05 0.0824 0.4746 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 M24 mock treatment 88440.0 8210.0 0.32 42280.0 -6530.0 -0.24 0.052 0.1294 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N01 compound treatment 100960.0 20700.0 0.8 26680.0 -22100.0 -0.83 -0.0185 -0.016 3083254 TimTec1_002751 Cc1cc2nnc(c3cccc4OCOc43)n2c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N02 compound treatment 30720.0 -49500.0 -1.92 1840.0 -47000.0 -1.76 -2.6049 -0.9991 3083257 TimTec1_002752 C/C=C\1/C(C)C(C(=C(N)N1c2ccc(cc2)C(=O)N)C#N)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N03 compound treatment 96960.0 16700.0 0.65 38720.0 -10100.0 -0.38 0.1913 0.2545 1231981 TimTec1_002753 Cc1ccc(cc1)C(=O)Cc2nc3ncccc3[nH]c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N04 compound treatment 116920.0 36700.0 1.42 56080.0 7270.0 0.27 1.1996 0.8276 1274147 TimTec1_002754 Sc1nc(CCN2C(=O)c3ccccc3C2=O)n[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N05 compound treatment 107240.0 27000.0 1.05 48040.0 -768.0 -0.03 0.7206 0.6874 3083260 TimTec1_002755 CC(=S)N1CCN(CC1)C(=S)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N06 compound treatment 119000.0 38800.0 1.5 55200.0 6390.0 0.24 1.2333 0.8097 1517166 TimTec1_002756 Cc1ccccc1N2C(=O)c3ccccc3NC2(C)CC(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N07 compound treatment 124120.0 43900.0 1.7 37320.0 -11500.0 -0.43 0.8993 0.5119 1118059 TimTec1_002757 Nn1c(=O)c(Cc2ccco2)n[nH]c1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N08 compound treatment 108080.0 27800.0 1.08 41640.0 -7170.0 -0.27 0.5738 0.5153 1361841 TimTec1_002758 CCOC(=O)C1=C(NC(=S)C(CC=C)(C#N)C1c2cccnc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N09 compound treatment 111200.0 31000.0 1.2 45240.0 -3570.0 -0.13 0.755 0.6244 3083263 TimTec1_002759 COC(=O)CNc1cc(C)c(cc1OC)C(O)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N10 compound treatment 112880.0 32600.0 1.27 46960.0 -1850.0 -0.07 0.8467 0.6674 1187305 TimTec1_002760 CCCC(=O)Nc1ccc2[nH]c(=O)[nH]c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N11 compound treatment 123560.0 43300.0 1.68 54440.0 5630.0 0.21 1.3382 0.7898 1455249 TimTec1_002761 CC(=O)Oc1ccc2occ(C(=O)c3ccc(F)cc3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N12 compound treatment 118520.0 38300.0 1.49 74080.0 25300.0 0.95 1.7212 0.9765 1149353 TimTec1_002762 COc1ccc(cc1)C(C#N)N2N=C(C)CC2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N13 compound treatment 98640.0 18400.0 0.71 51840.0 3030.0 0.11 0.5855 0.8096 1491757 TimTec1_002763 Clc1cccc(NC(=O)C(NC=O)c2ccccc2Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N14 compound treatment 114440.0 34200.0 1.33 58960.0 10200.0 0.38 1.208 0.8748 3209243 TimTec1_002764 OC(=O)[C@@H]1CCCN1Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N15 compound treatment 112360.0 32100.0 1.25 43600.0 -5210.0 -0.2 0.7433 0.589 3083267 TimTec1_002765 OC(=O)CCc1nnc(S)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N16 compound treatment 104320.0 24100.0 0.93 39240.0 -9570.0 -0.36 0.407 0.4065 1446498 TimTec1_002766 O=C(NC1CCCCCCCCCCC1)c2nc[nH]n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N17 compound treatment 110560.0 30300.0 1.18 39040.0 -9770.0 -0.37 0.5729 0.4648 3209244 TimTec1_002767 COc1ccc(cc1)[C@H]2[C@@H](C#N)[C@H](C#N)N3CCCN23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N18 compound treatment 103760.0 23500.0 0.91 35960.0 -12800.0 -0.48 0.3046 0.295 1206859 TimTec1_002768 Brc1cncc(c1)C(=O)Nc2ccc(cc2)C(=O)NC3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N19 compound treatment 105400.0 25200.0 0.98 35280.0 -13500.0 -0.51 0.3315 0.3012 1560261 TimTec1_002769 COc1ccc(cc1)C2NCCc3cc(OC)c(OC)cc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N20 compound treatment 7520.0 -72700.0 -2.82 2960.0 -45800.0 -1.72 -3.2116 -0.9719 3209245 TimTec1_002770 CN(C)c1nc(NCc2ccccc2)nc(Nc3ccc(OC(F)(F)F)cc3)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N21 compound treatment 90560.0 10300.0 0.4 41120.0 -7690.0 -0.29 0.0794 0.1607 1425208 TimTec1_002771 CN(CC(=O)O)S(=O)(=O)c1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N22 compound treatment 78160.0 -2070.0 -0.08 35360.0 -13400.0 -0.5 -0.4137 -0.8095 3209246 TimTec1_002772 Nn1c(CSCc2ccccc2)nnc1CSCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N23 mock treatment 102800.0 22600.0 0.88 45040.0 -3770.0 -0.14 0.5192 0.5853 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 N24 mock treatment 111720.0 31500.0 1.22 46320.0 -2490.0 -0.09 0.7979 0.6512 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O01 compound treatment 75120.0 -5110.0 -0.2 3960.0 -44800.0 -1.68 -1.3304 -0.785 3083272 TimTec1_002773 C(Nc1nonc1c2ncon2)n3nnc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O02 compound treatment 76120.0 -4110.0 -0.16 9640.0 -39200.0 -1.47 -1.1523 -0.7793 3209247 TimTec1_002774 O=C(NC1CCCCC1)/C=C/c2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O03 compound treatment 70800.0 -9430.0 -0.37 10000.0 -38800.0 -1.46 -1.2887 -0.8581 3209248 TimTec1_002775 O=C(NCCc1ccccc1)c2c(/N=C/3\C(=O)Nc4ccccc34)sc5CCCCc25 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O04 compound treatment 99080.0 18800.0 0.73 16560.0 -32200.0 -1.21 -0.3387 -0.2395 1468374 TimTec1_002776 OC(c1cccs1)c2ccc3OCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O05 compound treatment 28520.0 -51700.0 -2.01 3880.0 -44900.0 -1.69 -2.6111 -0.9963 3209249 TimTec1_002777 Clc1ccc(Cl)c(c1)N2C(SCC2=O)/C=C/c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O06 compound treatment 134520.0 54300.0 2.11 15160.0 -33600.0 -1.26 0.5965 0.2429 1257164 TimTec1_002778 Cc1ccc(C)c(NCc2ccccc2CO)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O07 compound treatment 51080.0 -29200.0 -1.13 4080.0 -44700.0 -1.68 -1.9868 -0.9815 3083858 TimTec1_002779 Cc1nc2ccccc2nc1Sc3nnc(o3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O08 compound treatment 55880.0 -24400.0 -0.94 5760.0 -43000.0 -1.62 -1.8105 -0.9674 1918856 TimTec1_002780 Brc1ccc(/C=N/c2cccc3ccccc23)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O09 compound treatment 60720.0 -19500.0 -0.76 10840.0 -38000.0 -1.42 -1.5429 -0.9562 3209250 TimTec1_002781 COc1ccc(Br)cc1/C=C/2\C(=O)NC(=O)N(CCC3=CCCCC3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O10 compound treatment 88640.0 8410.0 0.33 13400.0 -35400.0 -1.33 -0.709 -0.5181 3209251 TimTec1_002782 N#Cc1ccc(/C=N/c2cccc(C#N)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O11 compound treatment 99840.0 19600.0 0.76 14320.0 -34500.0 -1.29 -0.3773 -0.2513 3083924 TimTec1_002783 CCN1C(=C)c2cc(C)cc(C)c2NC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O12 compound treatment 97600.0 17400.0 0.67 27000.0 -21800.0 -0.82 -0.1022 -0.0964 3209252 TimTec1_002784 COc1ccc2ccccc2c1/C=N/c3ccccc3C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O13 compound treatment 51840.0 -28400.0 -1.1 22120.0 -26700.0 -1.0 -1.4872 -0.9989 1178846 TimTec1_002785 C=CCSc1nc2ccccc2c(=O)n1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O14 compound treatment 106520.0 26300.0 1.02 32920.0 -15900.0 -0.6 0.2996 0.2536 3209253 TimTec1_002786 Cc1ccc(/C=N/c2ccc(\N=C\c3ccc(C)s3)cc2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O15 compound treatment 63120.0 -17100.0 -0.66 24080.0 -24700.0 -0.93 -1.1257 -0.9865 1364793 TimTec1_002787 CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc2sc(C)c(C)c2C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O16 compound treatment 21640.0 -58600.0 -2.27 5320.0 -43500.0 -1.63 -2.7616 -0.9868 3209254 TimTec1_002788 Cc1c(Cc2ccccc2)sc(/N=C/c3ccc(Cl)cc3)c1C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O17 compound treatment 120960.0 40700.0 1.58 62480.0 13700.0 0.51 1.4803 0.8909 1685792 TimTec1_002789 COc1ccc2c(Cl)c(sc2c1)C(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O18 compound treatment 30760.0 -49500.0 -1.92 22000.0 -26800.0 -1.01 -2.0687 -0.9546 1138448 TimTec1_002790 O=C(CSc1nc2CCCCc2cc1C#N)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O19 compound treatment 117280.0 37000.0 1.44 39360.0 -9450.0 -0.35 0.7657 0.5172 3083928 TimTec1_002791 CSc1ccc(/C=N/c2ccc(C)c(C)c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O20 compound treatment 35280.0 -45000.0 -1.74 15240.0 -33600.0 -1.26 -2.1241 -0.9873 1253093 TimTec1_002792 CCOc1cccc(=O)c2c(C)n(c(C)c12)c3ccc(OC)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O21 compound treatment 68200.0 -12000.0 -0.47 30560.0 -18200.0 -0.68 -0.8144 -0.9825 3083930 TimTec1_002793 Cc1ccc(/C=N/c2ccc3ccccc3c2)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O22 compound treatment 100320.0 20100.0 0.78 47240.0 -1570.0 -0.06 0.5096 0.6519 3209255 TimTec1_002794 C/C(=N/Cc1nnc(C)s1)/c2cc3c(=O)n(C)c4ccccc4c3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O23 mock treatment 90960.0 10700.0 0.42 47160.0 -1650.0 -0.06 0.2506 0.5955 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 O24 mock treatment 104280.0 24000.0 0.93 39520.0 -9290.0 -0.35 0.4133 0.4149 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P01 compound treatment 52520.0 -27700.0 -1.08 37680.0 -11100.0 -0.42 -1.0556 -0.9152 3083932 TimTec1_002795 CC1=CC(=O)N(C1=O)c2c(C)n(C)n(c3ccccc3)c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P02 compound treatment 79680.0 -551.0 -0.02 48040.0 -768.0 -0.03 -0.0355 -0.9893 3209256 TimTec1_002796 CNC(=O)C1=CC(C)(C)NC1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P03 compound treatment 77840.0 -2390.0 -0.09 28280.0 -20500.0 -0.77 -0.6104 -0.7866 1174268 TimTec1_002797 Clc1ccc(cc1)C(=O)C(=C2NCCN2)n3ccnc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P04 compound treatment 102560.0 22300.0 0.87 38360.0 -10400.0 -0.39 0.3353 0.3526 1414675 TimTec1_002798 O=C(N1CCOCC1)c2ccc(s2)C(=O)N3CCOCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P05 compound treatment 104720.0 24500.0 0.95 30320.0 -18500.0 -0.69 0.1812 0.154 1495833 TimTec1_002799 COc1ccc(cc1OC)C2=NCC(C)(C)CO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P06 compound treatment 6080.0 -74200.0 -2.88 1680.0 -47100.0 -1.77 -3.2851 -0.9727 1678629 TimTec1_002800 COc1ccccc1C(=O)Nc2ccc(cc2)c3cn4ccccc4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P07 compound treatment 113280.0 33000.0 1.28 34400.0 -14400.0 -0.54 0.5244 0.3768 3209373 TimTec1_002801 CCn1c(=O)c(C/2=NNC(=O)\C2=C/Nc3nccs3)c(O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P08 compound treatment 106040.0 25800.0 1.0 32760.0 -16000.0 -0.6 0.2822 0.2415 1514165 TimTec1_002802 COc1ccc(cc1)C(C#N)N2CCC(=N2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P09 compound treatment 105040.0 24800.0 0.96 30520.0 -18300.0 -0.69 0.1953 0.1652 1619442 TimTec1_002803 Nc1cccc(c1)C(=O)OC2CSC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P10 compound treatment 77720.0 -2510.0 -0.1 16080.0 -32700.0 -1.23 -0.9375 -0.7608 3209374 TimTec1_002804 Cc1ccc(OCCSc2ncnc3ccccc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P11 compound treatment 106920.0 26700.0 1.04 33560.0 -15200.0 -0.57 0.3276 0.2769 1011278 TimTec1_002805 OC(=O)CNC(=O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P12 compound treatment 120200.0 40000.0 1.55 53880.0 5070.0 0.19 1.2312 0.788 1159913 TimTec1_002806 NC(=O)Cc1nc(cs1)c2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P13 compound treatment 104080.0 23800.0 0.93 46000.0 -2810.0 -0.11 0.5798 0.6226 1445633 TimTec1_002807 CCC(=O)c1cc2OCCOc2cc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P14 compound treatment 107160.0 26900.0 1.04 38880.0 -9930.0 -0.37 0.4753 0.4285 1468490 TimTec1_002808 Clc1ccccc1CS(=O)(=O)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P15 compound treatment 90120.0 9890.0 0.38 27400.0 -21400.0 -0.8 -0.2968 -0.3334 1633493 TimTec1_002809 NC(=O)CSc1nc2ccccc2c(=O)n1Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P16 compound treatment 96680.0 16400.0 0.64 31520.0 -17300.0 -0.65 -0.0075 -0.0082 1674139 TimTec1_002810 CCOC(=O)C1CCN(CC1)C(=O)c2ccccc2NC(=O)c3cccc(F)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P17 compound treatment 104840.0 24600.0 0.95 30440.0 -18400.0 -0.69 0.1877 0.1594 1703140 TimTec1_002811 OC(=O)CC1(O)N(Cc2ccccc2)C(=O)c3ccccc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P18 compound treatment 105960.0 25700.0 1.0 33480.0 -15300.0 -0.58 0.2991 0.2596 3084009 TimTec1_002812 COC(=O)C1=CN(CC2CCCO2)C=C(C1c3ccccc3)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P19 compound treatment 91240.0 11000.0 0.43 24040.0 -24800.0 -0.93 -0.3553 -0.3473 1281947 TimTec1_002813 CC1(C)CC(=C(C(C(C#N)C(=S)N)c2ccc(Cl)cc2)C(=O)C1)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P20 compound treatment 44240.0 -36000.0 -1.4 14960.0 -33800.0 -1.27 -1.8857 -0.9989 3084012 TimTec1_002814 O=C(C1CCCC1)N2CCc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P21 compound treatment 93920.0 13700.0 0.53 37080.0 -11700.0 -0.44 0.0643 0.0933 1667550 TimTec1_002815 Clc1ccccc1C(=O)N2CC(CC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P22 compound treatment 83160.0 2930.0 0.11 31240.0 -17600.0 -0.66 -0.3859 -0.5767 3209375 TimTec1_002816 CC(=O)NC(N1CCCCC1c2cccnc2)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P23 mock treatment 72880.0 -7350.0 -0.29 44240.0 -4570.0 -0.17 -0.3229 -0.9703 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2070 P24 mock treatment 49000.0 -31200.0 -1.21 27920.0 -20900.0 -0.78 -1.4112 -0.9778 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A01 compound treatment 85600.0 -45600.0 -1.77 103400.0 -46900.0 -1.76 -2.4963 -1.0 1179025 TimTec1_005281 Cc1c(OCC(=O)O)ccc2c(cc(=O)oc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A02 compound treatment 182720.0 51500.0 2.0 161800.0 11500.0 0.43 1.7182 0.8399 3212329 TimTec1_005282 C(=N/c1nccs1)\c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A03 compound treatment 209760.0 78600.0 3.05 179680.0 29300.0 1.1 2.9346 0.9052 1341807 TimTec1_005283 CCc1cc2c(=O)c(c3nc4ccccc4s3)c(C)oc2c(CN(C)C)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A04 compound treatment 124240.0 -6930.0 -0.27 99480.0 -50900.0 -1.91 -1.5402 -0.7988 3086205 TimTec1_005284 Cc1cc(C)c(C#N)c(SCC(=O)c2ccccc2)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A05 compound treatment 183120.0 51900.0 2.02 139800.0 -10500.0 -0.4 1.1453 0.5576 1015158 TimTec1_005285 COC(=O)c1ccc(NN)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A06 compound treatment 144280.0 13100.0 0.51 112840.0 -37500.0 -1.41 -0.6358 -0.4248 1579854 TimTec1_005286 Nc1nc(cs1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A07 compound treatment 117080.0 -14100.0 -0.55 55520.0 -94800.0 -3.56 -2.9033 -0.8063 3086207 TimTec1_005287 CC(C)c1cc(I)c(C)cc1OC(=O)NC(=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A08 compound treatment 161920.0 30700.0 1.19 146960.0 -3390.0 -0.13 0.7537 0.6282 1603281 TimTec1_005288 O=C(NCc1ccccc1)C2CCCN2C(=O)OCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A09 compound treatment 61920.0 -69300.0 -2.69 38000.0 -112000.0 -4.22 -4.8816 -0.9763 1494738 TimTec1_005289 O=C(Cn1c(=S)[nH]c2ccccc12)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A10 compound treatment 8440.0 -123000.0 -4.76 7240.0 -143000.0 -5.37 -7.1652 -0.9982 1405927 TimTec1_005290 Cc1cc(C)c(c(C)c1)S(=O)(=O)NCC2(OC3C=C2)C4C3C(=O)N(C4=O)c5ccc(Cl)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A11 compound treatment 179160.0 48000.0 1.86 170520.0 20200.0 0.76 1.8519 0.9214 1153776 TimTec1_005291 Cc1c(CCC(=O)NN)c(C)n2c3ccccc3nc2c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A12 compound treatment 181800.0 50600.0 1.96 178320.0 28000.0 1.05 2.1314 0.9569 3086211 TimTec1_005292 COc1cc(/C=N/Cc2ccco2)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A13 compound treatment 168640.0 37500.0 1.45 174560.0 24200.0 0.91 1.6705 0.9744 1733511 TimTec1_005293 CC1(C)CC(CCO1)C(=O)COc2ccc3ccc(=O)oc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A14 compound treatment 172080.0 40900.0 1.59 179240.0 28900.0 1.08 1.8891 0.9827 1139337 TimTec1_005294 C(Oc1ccccc1OCc2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A15 compound treatment 167200.0 36000.0 1.4 135040.0 -15300.0 -0.57 0.5822 0.3852 3212403 TimTec1_005295 O=C(NC(SC1=NCCS1)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A16 compound treatment 181520.0 50300.0 1.95 169720.0 19400.0 0.73 1.8955 0.9093 3086214 TimTec1_005296 CC(C)(CCN1CCOCC1)NC(=O)C=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A17 compound treatment 168640.0 37500.0 1.45 148480.0 -1870.0 -0.07 0.9784 0.6722 1301247 TimTec1_005297 COc1cc2c(C(=O)O)c(C)oc2cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A18 compound treatment 149400.0 18200.0 0.71 127520.0 -22800.0 -0.86 -0.1057 -0.0952 1734603 TimTec1_005298 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C2c3ccoc3)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A19 compound treatment 131560.0 389.0 0.02 97560.0 -52800.0 -1.98 -1.3903 -0.7017 3212404 TimTec1_005299 CN1CCc2[nH]c(=S)c(C#N)c(c3ccccc3)c2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A20 compound treatment 125240.0 -5930.0 -0.23 109120.0 -41200.0 -1.55 -1.2569 -0.8034 3086280 TimTec1_005300 COC(=O)/C=C\1/Nc2ccccc2SC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A21 compound treatment 98200.0 -33000.0 -1.28 75720.0 -74600.0 -2.8 -2.8852 -0.937 3212405 TimTec1_005301 Cc1cccc(NCN2C(=O)S/C(=C\c3cccc(F)c3)/C2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A22 compound treatment 5840.0 -125000.0 -4.86 5760.0 -145000.0 -5.43 -7.2758 -0.9985 1421857 TimTec1_005302 COc1ccc(cc1OC)C(=O)Nc2nnc(o2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A23 mock treatment 176000.0 44800.0 1.74 164360.0 14000.0 0.53 1.6018 0.8815 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 A24 mock treatment 148080.0 16900.0 0.66 158600.0 8250.0 0.31 0.6829 0.9413 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B01 compound treatment 211480.0 80300.0 3.12 186160.0 35800.0 1.34 3.1537 0.9293 3212406 TimTec1_005303 CC(C)P(C(C)C)c1ccc(C#N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B02 compound treatment 181320.0 50100.0 1.95 144360.0 -5990.0 -0.22 1.2169 0.6213 3212407 TimTec1_005304 CC(C)COc1ccc(/C=C\2/S\C(=N/c3ccccc3)\N(N(C)C)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B03 compound treatment 207200.0 76000.0 2.95 175200.0 24900.0 0.93 2.7454 0.8874 1371685 TimTec1_005305 O=C(NCc1cccnc1)c2cc3ccccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B04 compound treatment 166440.0 35300.0 1.37 129000.0 -21300.0 -0.8 0.4011 0.2529 3086285 TimTec1_005306 COc1cc(OC)c(/C=N/c2ccccc2)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B05 compound treatment 170120.0 38900.0 1.51 175320.0 25000.0 0.94 1.7313 0.9736 1138064 TimTec1_005307 OP(=O)(CCN1CCCC1=O)CN2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B06 compound treatment 141360.0 10200.0 0.4 146120.0 -4230.0 -0.16 0.1673 0.3928 1556230 TimTec1_005308 COc1ccc2CCC(C(=O)c2c1)C3(O)C(=O)Nc4ccccc43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B07 compound treatment 138520.0 7350.0 0.29 118800.0 -31500.0 -1.18 -0.6356 -0.5219 3086287 TimTec1_005309 CCC(NC(=O)Oc1ccc2ccccc2c1)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B08 compound treatment 144680.0 13500.0 0.52 170520.0 20200.0 0.76 0.906 0.9839 1141795 TimTec1_005310 CCC(Sc1nnc2c3ccccc3n(C)c2n1)C(=O)Nc4ccccc4C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B09 compound treatment 75520.0 -55700.0 -2.16 64920.0 -85400.0 -3.21 -3.794 -0.9815 3086290 TimTec1_005311 Cc1ccc2cccc(SCc3ccc(Br)cc3)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B10 compound treatment 129240.0 -1930.0 -0.07 144720.0 -5630.0 -0.21 -0.2024 -0.9028 1716446 TimTec1_005312 Clc1cc(NC2CCCCC2)c3C(=O)c4ccccc4-c5onc1c53 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B11 compound treatment 16800.0 -114000.0 -4.44 16360.0 -134000.0 -5.03 -6.6938 -0.9981 3212408 TimTec1_005313 COc1cc(ccc1O)c2nc3ccccn3c2/N=C/c4cccc(Cl)c4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B12 compound treatment 160280.0 29100.0 1.13 188080.0 37700.0 1.42 1.8 0.9937 1140826 TimTec1_005314 OC1(CCN([C@@H]2CCCC[C@@H]21)C(=O)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B13 compound treatment 155080.0 23900.0 0.93 177200.0 26900.0 1.01 1.3686 0.9991 1456412 TimTec1_005315 CN(CP(=O)(O)CCc1ccccc1)C=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B14 compound treatment 147560.0 16400.0 0.64 174400.0 24100.0 0.9 1.0879 0.9853 1674110 TimTec1_005316 Cc1ccc(C)c(NC(=O)C2CC(O)CN2C(=O)OC(C)(C)C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B15 compound treatment 139160.0 7990.0 0.31 172880.0 22500.0 0.85 0.8171 0.9073 3212409 TimTec1_005317 CCN(CC)S(=O)(=O)c1ncn[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B16 compound treatment 9760.0 -121000.0 -4.71 9000.0 -141000.0 -5.31 -7.0823 -0.9982 3212410 TimTec1_005318 Oc1ccccc1/C=C\2/S\C(=N/c3ccccc3)\N(Cc4ccccc4)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B17 compound treatment 125200.0 -5970.0 -0.23 83960.0 -66400.0 -2.49 -1.9257 -0.7695 1238350 TimTec1_005319 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)Oc2cccc(c2)c3cnc4ccccc4n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B18 compound treatment 9480.0 -122000.0 -4.72 7240.0 -143000.0 -5.37 -7.1367 -0.9979 1373281 TimTec1_005320 OC(C#CC(O)(c1ccccc1)c2ccccc2)c3ccc(F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B19 compound treatment 149440.0 18300.0 0.71 131080.0 -19300.0 -0.72 -0.0101 -0.01 1306989 TimTec1_005321 COc1ccc2N(Cn3nc(c4ccccc4)n(c5ccccc5)c3=S)CCCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B20 compound treatment 140320.0 9150.0 0.35 150200.0 -149.0 -0.01 0.2471 0.6959 1546728 TimTec1_005322 O=C(c1ccccc1)c2nc3ccccc3[nH]c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B21 compound treatment 7720.0 -123000.0 -4.79 6520.0 -144000.0 -5.4 -7.2041 -0.9982 3086367 TimTec1_005323 COC(=O)C1=C(C)N(/C(=C/c2cccc3ccccc23)/C1=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B22 compound treatment 15440.0 -116000.0 -4.49 8640.0 -142000.0 -5.32 -6.936 -0.9965 3086369 TimTec1_005324 O=C(/C=C/c1ccco1)C2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B23 mock treatment 175480.0 44300.0 1.72 167360.0 17000.0 0.64 1.6671 0.909 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 B24 mock treatment 176920.0 45700.0 1.78 159880.0 9530.0 0.36 1.5081 0.8329 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C01 compound treatment 146400.0 15200.0 0.59 83440.0 -66900.0 -2.51 -1.3579 -0.5263 1366978 TimTec1_005325 Cc1cc(=O)oc2cc(OC(=O)C3CCCN3C(=O)OC(C)(C)C)c(Cl)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C02 compound treatment 85920.0 -45300.0 -1.76 81760.0 -68600.0 -2.57 -3.0618 -0.9826 3086371 TimTec1_005326 NC1=C(C#N)C(c2ccccc2)c3ccc(N)cc3O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C03 compound treatment 165400.0 34200.0 1.33 123480.0 -26900.0 -1.01 0.226 0.1355 1640630 TimTec1_005327 CCN(CC)Cc1c(O)ccc2cc(c3nc4ccccc4[nH]3)c(=O)oc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C04 compound treatment 37040.0 -94100.0 -3.65 24720.0 -126000.0 -4.72 -5.9166 -0.992 1378375 TimTec1_005328 O=C(Oc1ccccc1OC(=O)C2C3CCCCC23)C4C5CCCCC45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C05 compound treatment 135720.0 4550.0 0.18 147720.0 -2630.0 -0.1 0.055 0.2722 1495247 TimTec1_005329 Brc1ccc(OCC(=O)Nc2ccccc2N3C(=O)c4ccccc4C3=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C06 compound treatment 94560.0 -36600.0 -1.42 81960.0 -68400.0 -2.57 -2.8194 -0.9611 3212411 TimTec1_005330 C(=N/c1ccc2[nH]c(nc2c1)c3ccccc3)\c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C07 compound treatment 99520.0 -31700.0 -1.23 88640.0 -61700.0 -2.32 -2.5061 -0.956 3212412 TimTec1_005331 CCOC(=O)NC1(N/C(=N/c2ccccc2)/N3CCOCC3)Oc4ccccc4O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C08 compound treatment 55840.0 -75300.0 -2.92 35200.0 -115000.0 -4.32 -5.1227 -0.9819 1281134 TimTec1_005332 COc1ccccc1NC(=O)C2CC2(c3ccc(C)cc3)c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C09 compound treatment 21440.0 -110000.0 -4.26 9560.0 -141000.0 -5.28 -6.747 -0.9943 1467004 TimTec1_005333 Cc1cc(C)c(C(=O)Cn2c(=S)[nH]c3ccccc23)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C10 compound treatment 127240.0 -3930.0 -0.15 158360.0 8010.0 0.3 0.1048 0.3107 3086377 TimTec1_005334 COc1ccc(/C=N/CCN2Cc3ccccc3C2=O)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C11 compound treatment 127600.0 -3570.0 -0.14 188000.0 37700.0 1.41 0.9013 0.6347 1653534 TimTec1_005335 CCOC(=O)CCc1c(C)c(C#N)c2nc3ccccc3n2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C12 compound treatment 108600.0 -22600.0 -0.88 143520.0 -6830.0 -0.26 -0.8005 -0.8772 3086379 TimTec1_005336 Cc1cc(=O)oc2cc(OC(=O)/C=C/c3ccccc3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C13 compound treatment 103240.0 -27900.0 -1.08 120920.0 -29400.0 -1.1 -1.5473 -1.0 3212413 TimTec1_005337 CC(C)NC(=O)n1cc(F)c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C14 compound treatment 132080.0 909.0 0.04 154280.0 3930.0 0.15 0.1293 0.8521 3086381 TimTec1_005338 CC(C)COc1ccccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C15 compound treatment 116760.0 -14400.0 -0.56 105880.0 -44500.0 -1.67 -1.5755 -0.8951 1498433 TimTec1_005339 O=C(NC(OCc1ccccc1)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C16 compound treatment 107160.0 -24000.0 -0.93 115520.0 -34800.0 -1.31 -1.5831 -0.9862 3212414 TimTec1_005340 CN(C(=O)C)c1ccc(/N=C\2/C(=O)Nc3ccc(C)c(Br)c23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C17 compound treatment 57880.0 -73300.0 -2.84 47080.0 -103000.0 -3.88 -4.7515 -0.9884 3086384 TimTec1_005341 C1Cc2c(C1)c3ccccc3n2c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C18 compound treatment 13560.0 -118000.0 -4.56 8520.0 -142000.0 -5.32 -6.9908 -0.9971 1222403 TimTec1_005342 Nc1c(sc2snc(SCC(=O)c3ccccc3)c12)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C19 compound treatment 118640.0 -12500.0 -0.49 117080.0 -33300.0 -1.25 -1.2267 -0.9155 3086386 TimTec1_005343 CC(C)(C)NC(=O)CSc1nc(N)c(C#N)cc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C20 compound treatment 129440.0 -1730.0 -0.07 133680.0 -16700.0 -0.63 -0.4899 -0.7785 1290278 TimTec1_005344 COC(=O)C(CCCN1C(=O)c2ccccc2C1=O)(NC(=O)C)c3nn[nH]n3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C21 compound treatment 124680.0 -6490.0 -0.25 109200.0 -41100.0 -1.54 -1.2701 -0.8117 3086388 TimTec1_005345 COc1ccc(cc1)c2nc3cc(/N=C/c4cccc(OC)c4O)ccc3o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C22 compound treatment 22920.0 -108000.0 -4.2 11920.0 -138000.0 -5.2 -6.6437 -0.9944 3212415 TimTec1_005346 COc1ccc(O)c(/C=N/c2cc(ccc2Oc3ccccc3)C(F)(F)F)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C23 mock treatment 128760.0 -2410.0 -0.09 144160.0 -6190.0 -0.23 -0.2304 -0.9201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 C24 mock treatment 154000.0 22800.0 0.89 153640.0 3290.0 0.12 0.7137 0.798 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D01 compound treatment 35200.0 -96000.0 -3.72 12640.0 -138000.0 -5.17 -6.2877 -0.9871 1377147 TimTec1_005347 CCC1=NN(C(=O)c2ccccc2F)C(O)(C1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D02 compound treatment 194000.0 62800.0 2.44 148560.0 -1790.0 -0.07 1.6763 0.6874 1581632 TimTec1_005348 OC(=O)CCC(=O)N(Cc1ccco1)C2CC(=O)N(C2=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D03 compound treatment 157040.0 25900.0 1.0 156680.0 6330.0 0.24 0.8778 0.851 1159067 TimTec1_005349 CC12C3CC(C=C3)C2C(=O)N(C1=O)c4cccc(c4)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D04 compound treatment 62680.0 -68500.0 -2.66 37960.0 -112000.0 -4.22 -4.8618 -0.9752 3086466 TimTec1_005350 OCCn/1c(cs\c1=N/c2ccccc2)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D05 compound treatment 64440.0 -66700.0 -2.59 37760.0 -113000.0 -4.23 -4.8188 -0.9724 1557266 TimTec1_005351 Clc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N4CCOCC4)sc3c2)c(Cl)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D06 compound treatment 125640.0 -5530.0 -0.21 84680.0 -65700.0 -2.46 -1.8945 -0.7658 3212725 TimTec1_005352 OC(=O)c1ccc(cc1)N2C(=O)CC(SC(=N)N3N=C(CC3c4ccccc4)c5ccccc5)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D07 compound treatment 133000.0 1830.0 0.07 140160.0 -10200.0 -0.38 -0.2202 -0.5662 3086469 TimTec1_005353 O=C(CSc1ncn[nH]1)OCN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D08 compound treatment 67120.0 -64100.0 -2.49 57760.0 -92600.0 -3.48 -4.2145 -0.9865 3086470 TimTec1_005354 CCN(CC)c1ccc(/C=C\2/S/C(=N\c3cccc(C)c3)/NC2=O)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D09 compound treatment 115000.0 -16200.0 -0.63 109960.0 -40400.0 -1.52 -1.5155 -0.9238 1301370 TimTec1_005355 Cc1cc(C)cc(c1)N2C(Nc3ccccc3C2=O)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D10 compound treatment 109600.0 -21600.0 -0.84 128040.0 -22300.0 -0.84 -1.1839 -1.0 3086472 TimTec1_005356 N/C(=C\C(=O)c1c(O)c(F)c(F)c(F)c1F)/C(=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D11 compound treatment 47800.0 -83400.0 -3.23 56600.0 -93700.0 -3.52 -4.7754 -0.9991 1471806 TimTec1_005357 Fc1ccc(cc1)N2C(Nc3ccccc3C2=O)c4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D12 compound treatment 87680.0 -43500.0 -1.69 87760.0 -62600.0 -2.35 -2.8543 -0.9868 3212726 TimTec1_005358 CCCC1=C(C(C(=C(N)O1)C#N)c2ccccc2OC)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D13 compound treatment 11440.0 -120000.0 -4.65 10120.0 -140000.0 -5.26 -7.0065 -0.9981 3086475 TimTec1_005359 Fc1ccc(/C=C/2\CN(Cc3ccccc3)C/C(=C/c4ccc(F)cc4)/C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D14 compound treatment 74680.0 -56500.0 -2.19 79080.0 -71300.0 -2.67 -3.4413 -0.9951 3212727 TimTec1_005360 CN1C(=O)/C(=C\C=C\c2ccccc2Cl)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D15 compound treatment 100600.0 -30600.0 -1.19 67760.0 -82600.0 -3.1 -3.0306 -0.9131 1327468 TimTec1_005361 NC1=C(C#N)C(C2=C(CCCC2=O)N1c3sc4CCCCCc4c3C#N)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D16 compound treatment 134200.0 3030.0 0.12 126720.0 -23600.0 -0.89 -0.544 -0.6081 1533582 TimTec1_005362 CCCn1c2ccccc2c3nnc(SCN4C(=O)c5ccccc5C4=O)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D17 compound treatment 111720.0 -19500.0 -0.75 104760.0 -45600.0 -1.71 -1.7435 -0.9323 1465950 TimTec1_005363 CCC(Sc1nnc2c3ccccc3n(C)c2n1)C(=O)Nc4ccc(cc4)S(=O)(=O)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D18 compound treatment 135400.0 4230.0 0.16 120400.0 -29900.0 -1.12 -0.6788 -0.5976 1384915 TimTec1_005364 Clc1cccc(NC(=O)COC(=O)c2ccc(cc2)N3C(=O)CCC3=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D19 compound treatment 126480.0 -4690.0 -0.18 140440.0 -9910.0 -0.37 -0.3917 -0.946 1450022 TimTec1_005365 COc1ccc2N(Cn3nc(COc4ccccc4)n(C)c3=S)CCCc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D20 compound treatment 133960.0 2790.0 0.11 121880.0 -28500.0 -1.07 -0.679 -0.6323 1291038 TimTec1_005366 CCC(O)C#CCN1CCN(C)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D21 compound treatment 54280.0 -76900.0 -2.98 41680.0 -109000.0 -4.08 -4.9935 -0.9882 1912707 TimTec1_005367 CC(C)(O)C(=O)/C=C/c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D22 compound treatment 122160.0 -9010.0 -0.35 107800.0 -42500.0 -1.6 -1.3764 -0.842 1025952 TimTec1_005368 Cc1cc(Cc2ccc(N)c(C)c2)ccc1N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D23 mock treatment 135760.0 4590.0 0.18 117320.0 -33000.0 -1.24 -0.7506 -0.5994 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 D24 mock treatment 131320.0 149.0 0.01 122240.0 -28100.0 -1.05 -0.7419 -0.7032 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E01 compound treatment 186840.0 55700.0 2.16 148000.0 -2350.0 -0.09 1.465 0.6777 2102259 TimTec1_005369 CC(C)CC(NCc1c(O)ccc2c(C)cc(=O)oc12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E02 compound treatment 169880.0 38700.0 1.5 110760.0 -39600.0 -1.49 0.0114 0.0054 3086481 TimTec1_005370 O=C1NC(=O)/C(=C\c2ccccc2)/N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E03 compound treatment 10600.0 -121000.0 -4.68 9200.0 -141000.0 -5.3 -7.0539 -0.9981 1012035 TimTec1_005371 CN1CCC(O)(C(C1)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E04 compound treatment 121640.0 -9530.0 -0.37 113600.0 -36700.0 -1.38 -1.2368 -0.8661 3212728 TimTec1_005372 CCc1ccc(cc1)C2C(=C(N)OC3=C2C(=O)CCC3)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E05 compound treatment 129000.0 -2170.0 -0.08 131800.0 -18500.0 -0.7 -0.5518 -0.7869 1629849 TimTec1_005373 CC(C)CN(CC(C)C)C(=O)CCN1C(=O)c2ccccc2C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E06 compound treatment 136600.0 5430.0 0.21 132200.0 -18100.0 -0.68 -0.3327 -0.4666 3212729 TimTec1_005374 CSc1nc2sc3COC(C)(C)Cc3c2c(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E07 compound treatment 11000.0 -120000.0 -4.66 10000.0 -140000.0 -5.27 -7.0217 -0.9981 3212730 TimTec1_005375 CC(C)c1ccc(C)cc1OC(=O)NC2(Oc3ccc(Cl)cc3O2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E08 compound treatment 129200.0 -1970.0 -0.08 128320.0 -22000.0 -0.83 -0.6387 -0.7692 1308284 TimTec1_005376 Cc1ccc(cc1)N2CC(=O)SC32CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E09 compound treatment 127560.0 -3610.0 -0.14 129960.0 -20400.0 -0.77 -0.6402 -0.8229 3085473 TimTec1_005377 COc1ccc(cc1)C2=CN3C(=O)CSC3=NN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E10 compound treatment 132200.0 1030.0 0.04 136560.0 -13800.0 -0.52 -0.3377 -0.6506 1639246 TimTec1_005378 CCOC(=O)c1c(CN2CCOCC2)oc3ccc(OC)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E11 compound treatment 131040.0 -131.0 -0.01 129640.0 -20700.0 -0.78 -0.5532 -0.7117 3085475 TimTec1_005379 CC(=C)Cn1c(S)nc2ccccc2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E12 compound treatment 19320.0 -112000.0 -4.34 18640.0 -132000.0 -4.94 -6.5641 -0.9979 3212731 TimTec1_005380 Cc1ccc(/C=C/2\OC(=O)C=C2)o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E13 compound treatment 117760.0 -13400.0 -0.52 128880.0 -21500.0 -0.81 -0.9377 -0.9776 1303286 TimTec1_005381 CCc1cc2c(=O)c(coc2cc1O)c3nc(C)cs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E14 compound treatment 16160.0 -115000.0 -4.46 15920.0 -134000.0 -5.05 -6.723 -0.9981 3085477 TimTec1_005382 O=C(CSc1nc(ccc1C#N)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E15 compound treatment 117880.0 -13300.0 -0.52 129440.0 -20900.0 -0.78 -0.9195 -0.9793 3212732 TimTec1_005383 COc1ccccc1N2CCN(CC2)/N=C/c3sccc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E16 compound treatment 129640.0 -1530.0 -0.06 129200.0 -21100.0 -0.79 -0.6033 -0.7579 1527733 TimTec1_005384 Nc1nonc1C(=O)NCc2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E17 compound treatment 10320.0 -121000.0 -4.69 9680.0 -141000.0 -5.28 -7.0489 -0.9983 3212733 TimTec1_005385 O=C1N([C@H]2CC(=O)[C@@H]3OCC2O3)S(=O)(=O)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E18 compound treatment 128640.0 -2530.0 -0.1 115600.0 -34700.0 -1.3 -0.9916 -0.7582 1204206 TimTec1_005386 CC(C)(C)NC(=O)CSc1nsc(SCC(=O)NC(C)(C)C)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E19 compound treatment 40000.0 -91200.0 -3.54 31800.0 -119000.0 -4.45 -5.6475 -0.9935 3212734 TimTec1_005387 NC1=C(C#N)C(C(=c2s/c(=C\c3ccco3)/c(=O)n12)C#N)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E20 compound treatment 93680.0 -37500.0 -1.45 81840.0 -68500.0 -2.57 -2.8468 -0.9636 1594563 TimTec1_005388 OC(=O)CCC(=O)Nc1ccccc1C#Cc2ccc(Br)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E21 compound treatment 98680.0 -32500.0 -1.26 100480.0 -49900.0 -1.87 -2.2149 -0.9815 3212735 TimTec1_005389 COc1cccc(/C=N/c2ccc(cc2)c3nc4ccc(C)cc4o3)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E22 compound treatment 128200.0 -2970.0 -0.12 97360.0 -53000.0 -1.99 -1.4878 -0.7468 3085483 TimTec1_005390 C/C=C/c1c(C)nc2sc(C#N)c(N)c2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E23 mock treatment 127640.0 -3530.0 -0.14 134600.0 -15700.0 -0.59 -0.5148 -0.8485 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 E24 mock treatment 134880.0 3710.0 0.14 125240.0 -25100.0 -0.94 -0.5646 -0.5923 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F01 compound treatment 173400.0 42200.0 1.64 103000.0 -47300.0 -1.78 -0.098 -0.0405 1199396 TimTec1_005391 O=C(NCc1cccs1)c2cccc(c2)S(=O)(=O)N3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F02 compound treatment 122960.0 -8210.0 -0.32 76560.0 -73800.0 -2.77 -2.1836 -0.7833 1438185 TimTec1_005392 N#Cc1ccc(cc1C#N)n2c(nnc2c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F03 compound treatment 143320.0 12100.0 0.47 125520.0 -24800.0 -0.93 -0.3256 -0.3118 1602974 TimTec1_005393 Cc1cc(C)c2oc(nc2c1)c3ccc(N)cc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F04 compound treatment 60240.0 -70900.0 -2.75 57800.0 -92500.0 -3.47 -4.4022 -0.9934 1565318 TimTec1_005394 COC(=O)C(C(Nc1ccccc1)c2ccccc2)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F05 compound treatment 131080.0 -91.0 0.0 125040.0 -25300.0 -0.95 -0.6742 -0.7097 3085487 TimTec1_005395 COC(=O)CSc1nc(C)nc2c3ccccc3oc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F06 compound treatment 163400.0 32200.0 1.25 146440.0 -3910.0 -0.15 0.7805 0.6199 3212736 TimTec1_005396 CN(C)c1ccc(/C=N/c2ccc3[nH]c(=O)[nH]c3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F07 compound treatment 131560.0 389.0 0.02 129880.0 -20500.0 -0.77 -0.5325 -0.6931 3085489 TimTec1_005397 CN(C)C(=O)/C(=C/c1ccc(F)cc1)/NC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F08 compound treatment 64160.0 -67000.0 -2.6 67480.0 -82900.0 -3.11 -4.0378 -0.996 3212737 TimTec1_005398 N#Cc1c(NCSCc2ccccc2)sc3CCCCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F09 compound treatment 11640.0 -120000.0 -4.64 13400.0 -137000.0 -5.14 -6.9139 -0.9987 1212031 TimTec1_005399 CC(C)(C)C(=O)Nc1cc(NC(=O)C(C)(C)C)cc(c1)C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F10 compound treatment 122960.0 -8210.0 -0.32 131960.0 -18400.0 -0.69 -0.7133 -0.9384 1476455 TimTec1_005400 CC(CS(=O)(=O)c1ccccc1)N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F11 compound treatment 10360.0 -121000.0 -4.69 9480.0 -141000.0 -5.29 -7.0531 -0.9982 1295263 TimTec1_005401 Cc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)c3nc4ccccc4o3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F12 compound treatment 92080.0 -39100.0 -1.52 99600.0 -50700.0 -1.9 -2.4193 -0.9936 1158028 TimTec1_005402 C(Sc1nnc2c3ccccc3n(Cc4ccccc4)c2n1)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F13 compound treatment 127160.0 -4010.0 -0.16 139800.0 -10500.0 -0.4 -0.39 -0.9168 3086060 TimTec1_005403 CCC(NC(=O)OC1CCCCC1C)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F14 compound treatment 120400.0 -10800.0 -0.42 127680.0 -22700.0 -0.85 -0.8971 -0.9464 3212738 TimTec1_005404 CN1C(=O)S/C(=C/c2cc(C)n(c2C)c3ccccc3)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F15 compound treatment 14640.0 -117000.0 -4.52 10360.0 -140000.0 -5.25 -6.9123 -0.9972 1322720 TimTec1_005405 CCOC(=O)c1c(CSc2ccccc2)oc3ccc(O)c(CN(C)C)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F16 compound treatment 94960.0 -36200.0 -1.4 91480.0 -58900.0 -2.21 -2.5558 -0.9761 1183235 TimTec1_005406 Cc1ccc2nc(NC(=O)C(Cc3ccccc3)NC(=O)OCc4ccccc4)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F17 compound treatment 113640.0 -17500.0 -0.68 118640.0 -31700.0 -1.19 -1.3225 -0.9648 1662436 TimTec1_005407 Nc1nonc1n2nnc(C(=O)N3CCCC3)c2c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F18 compound treatment 122040.0 -9130.0 -0.35 138080.0 -12300.0 -0.46 -0.5761 -0.9916 1606341 TimTec1_005408 COC(=O)C1=C(c2ccccc2)S(=O)(=O)CCN1C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F19 compound treatment 108320.0 -22900.0 -0.89 102760.0 -47600.0 -1.79 -1.8899 -0.9478 1282067 TimTec1_005409 COC(=O)c1ccc(NC(=O)CSc2nnc(N)s2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F20 compound treatment 125240.0 -5930.0 -0.23 121960.0 -28400.0 -1.07 -0.9161 -0.8405 3086064 TimTec1_005410 CSC1=NC(C)(C)Cc2c(C)cccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F21 compound treatment 141680.0 10500.0 0.41 134000.0 -16300.0 -0.61 -0.1456 -0.1976 1037267 TimTec1_005411 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F22 compound treatment 95200.0 -36000.0 -1.4 87080.0 -63300.0 -2.37 -2.666 -0.9679 1160915 TimTec1_005412 Cc1cccc(c1C)n2c(CSc3nc4ccccc4[nH]3)nc5ccccc5c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F23 mock treatment 120280.0 -10900.0 -0.42 124480.0 -25900.0 -0.97 -0.9853 -0.9305 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 F24 mock treatment 146880.0 15700.0 0.61 137960.0 -12400.0 -0.46 0.1022 0.1333 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G01 compound treatment 196000.0 64800.0 2.52 163760.0 13400.0 0.5 2.1346 0.8321 3086066 TimTec1_005413 CCC(C)C(NCc1c(O)ccc2c(C)cc(=O)oc12)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G02 compound treatment 180480.0 49300.0 1.91 121640.0 -28700.0 -1.08 0.5909 0.2691 3212809 TimTec1_005414 COC(=O)n1c(SC)nc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G03 compound treatment 170400.0 39200.0 1.52 122640.0 -27700.0 -1.04 0.3409 0.1849 1428822 TimTec1_005415 CC(C)c1ccccc1NC(=O)CN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G04 compound treatment 119280.0 -11900.0 -0.46 102720.0 -47600.0 -1.79 -1.5903 -0.8614 1673731 TimTec1_005416 C=CCN(CC=C)C(=S)Oc1ccc(cc1)C(=O)Nc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G05 compound treatment 139120.0 7950.0 0.31 133640.0 -16700.0 -0.63 -0.2253 -0.3225 3212810 TimTec1_005417 NNC(=O)c1cc(nn1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G06 compound treatment 133560.0 2390.0 0.09 129440.0 -20900.0 -0.78 -0.4894 -0.6193 3086070 TimTec1_005418 COC(=O)Nc1ccc(Br)cn1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G07 compound treatment 124800.0 -6370.0 -0.25 131680.0 -18700.0 -0.7 -0.6702 -0.9021 3212811 TimTec1_005419 CN/1N(C(=NC(=O)\C1=C/c2ccc(O)cc2)C)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G08 compound treatment 125400.0 -5770.0 -0.22 125920.0 -24400.0 -0.92 -0.8066 -0.8547 1496851 TimTec1_005420 CCSc1nc2-c3ccccc3CC4(CCCCC4)c2c(=O)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G09 compound treatment 123480.0 -7690.0 -0.3 131480.0 -18900.0 -0.71 -0.7118 -0.9262 3212812 TimTec1_005421 CC1SC2=NNC(=CN2C1=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G10 compound treatment 122480.0 -8690.0 -0.34 124680.0 -25700.0 -0.96 -0.9197 -0.901 1578108 TimTec1_005422 CC(=O)Oc1ccc(cc1)c2nc3ccccc3c(=O)o2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G11 compound treatment 34360.0 -96800.0 -3.76 36880.0 -113000.0 -4.26 -5.6674 -0.998 1637150 TimTec1_005423 Cc1ccc(cc1)S(=O)(=O)NCCC(=O)Oc2cc3oc(=O)c4CCCCc4c3cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G12 compound treatment 102160.0 -29000.0 -1.13 106280.0 -44100.0 -1.65 -1.9655 -0.9824 1014256 TimTec1_005424 c1c([nH]c2ccccc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G13 compound treatment 106680.0 -24500.0 -0.95 103440.0 -46900.0 -1.76 -1.9168 -0.9581 1442327 TimTec1_005425 CCc1cc(C(=O)Cc2nc(C)cs2)c(O)cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G14 compound treatment 116320.0 -14900.0 -0.58 125000.0 -25300.0 -0.95 -1.0802 -0.9711 3212813 TimTec1_005426 CCOc1cc(/C=N/CCN2Cc3ccccc3C2=O)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G15 compound treatment 119880.0 -11300.0 -0.44 128120.0 -22200.0 -0.83 -0.8997 -0.9548 3086140 TimTec1_005427 COc1ccc(/C=N/S(=O)(=O)c2ccccc2)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G16 compound treatment 114720.0 -16500.0 -0.64 98600.0 -51700.0 -1.94 -1.8247 -0.8925 3212814 TimTec1_005428 Clc1ccc(NC(=O)CSC(=O)c2ccccc2)nc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G17 compound treatment 21320.0 -110000.0 -4.26 22760.0 -128000.0 -4.79 -6.3999 -0.9983 3086142 TimTec1_005429 Oc1n[n+](no1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G18 compound treatment 110920.0 -20300.0 -0.79 115160.0 -35200.0 -1.32 -1.4895 -0.9692 3212815 TimTec1_005430 COc1cc(/C=N/c2oc(C)c(C)c2C#N)cc(Br)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G19 compound treatment 121200.0 -9970.0 -0.39 115880.0 -34500.0 -1.29 -1.1883 -0.8801 1400147 TimTec1_005431 Cc1ccccc1OCC(=O)Nc2cc(Sc3ccccn3)cc(c2)S(=O)(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G20 compound treatment 130120.0 -1050.0 -0.04 137560.0 -12800.0 -0.48 -0.3682 -0.7644 3086144 TimTec1_005432 C(=N/c1nnc2[nH]cnn12)\c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G21 compound treatment 127800.0 -3370.0 -0.13 127360.0 -23000.0 -0.86 -0.7026 -0.8051 1704603 TimTec1_005433 CCN(CC)C(=O)N1CCc2ccccc2C1CN3C(=O)c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G22 compound treatment 124600.0 -6570.0 -0.25 119440.0 -30900.0 -1.16 -1.0006 -0.8424 3212816 TimTec1_005434 CCc1c(C)[nH]c(=S)c(C#N)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G23 mock treatment 139440.0 8270.0 0.32 121800.0 -28500.0 -1.07 -0.5308 -0.4746 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 G24 mock treatment 130480.0 -691.0 -0.03 144080.0 -6270.0 -0.24 -0.1853 -0.7826 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H01 compound treatment 158200.0 27000.0 1.05 130480.0 -19900.0 -0.75 0.2143 0.1665 1451425 TimTec1_005435 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)Nc2nncs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H02 compound treatment 148440.0 17300.0 0.67 113360.0 -37000.0 -1.39 -0.5079 -0.3295 3086147 TimTec1_005436 COc1cc(/C=C\2/S\C(=N/c3ccccc3)\N(N(C)C)C2=O)cc(Br)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H03 compound treatment 165080.0 33900.0 1.32 128120.0 -22200.0 -0.83 0.3404 0.2185 3212817 TimTec1_005437 Cc1cc-2c(cn1)/C(=N\c3ccccc3C)/c4ccccc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H04 compound treatment 96200.0 -35000.0 -1.36 98680.0 -51700.0 -1.94 -2.3307 -0.9847 3086149 TimTec1_005438 Clc1ss/c(=N\c2ccccn2)/c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H05 compound treatment 117360.0 -13800.0 -0.54 118960.0 -31400.0 -1.18 -1.2119 -0.9364 1471924 TimTec1_005439 COC(=O)c1ccc2c(c1)sc3nc(cn32)c4ccc(OC)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H06 compound treatment 171880.0 40700.0 1.58 177840.0 27500.0 1.03 1.8465 0.9787 3212818 TimTec1_005440 Cc1ccc(/N=C/c2ccc3OCOc3c2)c(Br)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H07 compound treatment 126480.0 -4690.0 -0.18 122480.0 -27900.0 -1.05 -0.8683 -0.8179 1713930 TimTec1_005441 CC(C)C(O)(C#CCN1CCCCC1)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H08 compound treatment 130320.0 -851.0 -0.03 125160.0 -25200.0 -0.95 -0.6918 -0.7314 3212819 TimTec1_005442 CC(=O)NC1=NC(=O)/C(=C\c2ccc(Cl)cc2)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H09 compound treatment 126920.0 -4250.0 -0.16 132760.0 -17600.0 -0.66 -0.5834 -0.8574 1216409 TimTec1_005443 Nc1nnc(SCC(=O)NCc2ccco2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H10 compound treatment 33600.0 -97600.0 -3.79 22480.0 -128000.0 -4.8 -6.0705 -0.9931 3212820 TimTec1_005444 Cc1nc(Sc2ccccc2)c3oc4ccccc4c3n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H11 compound treatment 101880.0 -29300.0 -1.14 114320.0 -36000.0 -1.35 -1.7598 -0.9963 1240888 TimTec1_005445 O=C1CSC2(CCCCC2)N1Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H12 compound treatment 96840.0 -34300.0 -1.33 99600.0 -50700.0 -1.9 -2.2887 -0.9847 3212821 TimTec1_005446 Clc1ccc(NC(=O)CSC2=NCCS2)nc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H13 compound treatment 116560.0 -14600.0 -0.57 126480.0 -23900.0 -0.9 -1.0343 -0.9756 3212822 TimTec1_005447 COC(=O)C1=C(N)N(C2=C(C1c3ccccc3)C(=O)CCC2)c4cccc(c4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H14 compound treatment 37680.0 -93500.0 -3.63 34400.0 -116000.0 -4.35 -5.6422 -0.9959 1666111 TimTec1_005448 Oc1ccccc1N=c2c(=O)c3ccccc3c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H15 compound treatment 115560.0 -15600.0 -0.61 126280.0 -24100.0 -0.9 -1.0671 -0.9811 3086218 TimTec1_005449 O=C(NC1CC1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H16 compound treatment 121160.0 -10000.0 -0.39 125920.0 -24400.0 -0.92 -0.923 -0.9269 1687122 TimTec1_005450 COc1ccc(cc1)C2CC3(OCCO3)C4(CCCCC4)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H17 compound treatment 90720.0 -40500.0 -1.57 93520.0 -56800.0 -2.13 -2.618 -0.9886 3212823 TimTec1_005451 Clc1cccc(/C=C\2/SC(=NC2=O)N3CCCC3)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H18 compound treatment 104280.0 -26900.0 -1.04 107360.0 -43000.0 -1.61 -1.8787 -0.9777 1549014 TimTec1_005452 O=C(CSc1nnc2c3ccccc3[nH]c2n1)NCc4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H19 compound treatment 117720.0 -13500.0 -0.52 117480.0 -32900.0 -1.23 -1.2413 -0.9267 1530955 TimTec1_005453 COC(=O)C1=C(N)N(C2=C(C1c3ccccc3)C(=O)CC(C)(C)C2)c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H20 compound treatment 131280.0 109.0 0.0 124720.0 -25600.0 -0.96 -0.6772 -0.704 1138726 TimTec1_005454 CCOC(=O)c1ccccc1NCn2c(=S)oc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H21 compound treatment 122480.0 -8690.0 -0.34 121480.0 -28900.0 -1.08 -1.0046 -0.8853 1258567 TimTec1_005455 OC(=O)c1ccc2C(=O)N(C(=O)c2c1)c3cccc(c3)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H22 compound treatment 102160.0 -29000.0 -1.13 106280.0 -44100.0 -1.65 -1.9655 -0.9824 1345011 TimTec1_005456 OC(=O)c1ccccc1NC(=O)c2cc(ccc2Cl)S(=O)(=O)N3CCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H23 mock treatment 129080.0 -2090.0 -0.08 132480.0 -17900.0 -0.67 -0.5316 -0.7869 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 H24 mock treatment 129480.0 -1690.0 -0.07 136040.0 -14300.0 -0.54 -0.4261 -0.7876 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I01 compound treatment 85600.0 -45600.0 -1.77 71240.0 -79100.0 -2.97 -3.3497 -0.9693 1452955 TimTec1_005457 CCOC(=O)c1c(oc2ccc(OCC)cc12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I02 compound treatment 76800.0 -54400.0 -2.11 61360.0 -89000.0 -3.34 -3.8534 -0.9755 1419694 TimTec1_005458 CCCc1ccc2c(N)c(sc2n1)C(=O)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I03 compound treatment 163360.0 32200.0 1.25 125120.0 -25200.0 -0.95 0.2136 0.1363 1348330 TimTec1_005459 CCc1ccc(OC(=O)CN2C(=O)c3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I04 compound treatment 148160.0 17000.0 0.66 123640.0 -26700.0 -1.0 -0.2427 -0.2023 1011570 TimTec1_005460 COc1ccc2oc(=O)cc(C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I05 compound treatment 114080.0 -17100.0 -0.66 117640.0 -32700.0 -1.23 -1.337 -0.9582 1591902 TimTec1_005461 NNC(=O)Cc1nc2ccccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I06 compound treatment 10640.0 -121000.0 -4.68 11040.0 -139000.0 -5.23 -7.004 -0.9985 3086226 TimTec1_005462 CCCC(=O)n1c(=S)oc2cc(Cl)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I07 compound treatment 121760.0 -9410.0 -0.37 138080.0 -12300.0 -0.46 -0.5838 -0.9934 3212824 TimTec1_005463 Cc1ccc(cc1)C(=O)/N=c\2/n(C)n(c(C)nc2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I08 compound treatment 117040.0 -14100.0 -0.55 125080.0 -25300.0 -0.95 -1.0583 -0.9661 1332287 TimTec1_005464 NC(=O)CN(c1ccc(Cl)cc1Cl)S(=O)(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I09 compound treatment 55400.0 -75800.0 -2.94 68400.0 -81900.0 -3.08 -4.2537 -0.9997 1228160 TimTec1_005465 O=C(SCc1nc2ccccc2[nH]1)c3ccc(cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I10 compound treatment 95640.0 -35500.0 -1.38 100640.0 -49700.0 -1.87 -2.294 -0.9889 3212825 TimTec1_005466 Cc1ccc2cc3/C(=N\C4CCCCC4)/c5ccccc5-c3nc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I11 compound treatment 118560.0 -12600.0 -0.49 126080.0 -24300.0 -0.91 -0.9901 -0.9575 3086229 TimTec1_005467 Cc1ccc2nc(NCc3ccccc3)c(/C=N/c4ccc(Cl)cc4)c(=O)n2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I12 compound treatment 109080.0 -22100.0 -0.86 124960.0 -25400.0 -0.95 -1.2799 -0.9986 3212826 TimTec1_005468 COc1ccc(/N=C\2/c3ccccc3-c4nc5ccccc5nc24)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I13 compound treatment 113760.0 -17400.0 -0.68 120080.0 -30300.0 -1.14 -1.281 -0.9692 1582817 TimTec1_005469 CN(C)Cc1c(C)cc2oc(=O)c3CCCCc3c2c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I14 compound treatment 46240.0 -84900.0 -3.3 50960.0 -99400.0 -3.73 -4.9678 -0.9981 3086232 TimTec1_005470 CCc1ccc(cc1)c2nn(c3ccccc3)c(=S)c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I15 compound treatment 127320.0 -3850.0 -0.15 121160.0 -29200.0 -1.1 -0.8803 -0.7962 3212903 TimTec1_005471 CN(C)c1ccc(/C=N/S(=O)(=O)c2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I16 compound treatment 125640.0 -5530.0 -0.21 127760.0 -22600.0 -0.85 -0.7512 -0.859 1444311 TimTec1_005472 COC(=O)c1ccc(OC(=O)COC(=O)CN2C(=O)c3ccccc3C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I17 compound treatment 55720.0 -75500.0 -2.93 71520.0 -78800.0 -2.96 -4.1621 -1.0 3212904 TimTec1_005473 CSc1c(CC(=O)Nc2ccccc2)n(Cc3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I18 compound treatment 117480.0 -13700.0 -0.53 142480.0 -7870.0 -0.3 -0.5845 -0.9616 3086235 TimTec1_005474 Fc1ccc(/C=N/c2nnc3[nH]cnn23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I19 compound treatment 72000.0 -59200.0 -2.3 42040.0 -108000.0 -4.07 -4.4978 -0.9634 3212905 TimTec1_005475 CC(C)(C)c1ccc(cc1)c2nc3ccccc3s2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I20 compound treatment 119400.0 -11800.0 -0.46 119840.0 -30500.0 -1.15 -1.1326 -0.9188 3086300 TimTec1_005476 CCC1(C)OC(=O)N(C1=C)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I21 compound treatment 114520.0 -16700.0 -0.65 120680.0 -29700.0 -1.11 -1.2442 -0.9665 3086302 TimTec1_005477 COCc1cc(C)nc2snc(Br)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I22 compound treatment 125640.0 -5530.0 -0.21 123920.0 -26400.0 -0.99 -0.8531 -0.8406 3212906 TimTec1_005478 Cc1cc(C)c2c(N)c(sc2n1)C(=O)OC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I23 mock treatment 121600.0 -9570.0 -0.37 141120.0 -9230.0 -0.35 -0.5075 -0.9994 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 I24 mock treatment 135240.0 4070.0 0.16 165080.0 14700.0 0.55 0.5026 0.8741 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J01 compound treatment 94320.0 -36900.0 -1.43 116800.0 -33500.0 -1.26 -1.9014 -0.998 1654696 TimTec1_005479 CC(C)C1N(CCN1S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J02 compound treatment 208680.0 77500.0 3.01 133160.0 -17200.0 -0.65 1.6704 0.5431 3086304 TimTec1_005480 FC(F)(F)COc1nc(nc(n1)N2CCN(CC2)c3ccccc3)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J03 compound treatment 134040.0 2870.0 0.11 124920.0 -25400.0 -0.95 -0.5961 -0.6204 1724083 TimTec1_005481 NC1=C(C#N)C(C2=C(CCCC2=O)N1c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J04 compound treatment 114760.0 -16400.0 -0.64 114120.0 -36200.0 -1.36 -1.4117 -0.9402 3086306 TimTec1_005482 CCCCc1c(C)c2ccc(OCC=C)cc2oc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J05 compound treatment 9000.0 -122000.0 -4.74 9480.0 -141000.0 -5.29 -7.0904 -0.9985 3212907 TimTec1_005483 COC(=O)CSC1=NC(=O)/C(=C/c2ccc(OC)cc2)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J06 compound treatment 80800.0 -50400.0 -1.95 82520.0 -67800.0 -2.55 -3.1821 -0.9915 3086308 TimTec1_005484 Brc1cc2OCOc2cc1/C=N/c3c(nc4ccccn34)c5ccco5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J07 compound treatment 24480.0 -107000.0 -4.14 15840.0 -135000.0 -5.05 -6.4969 -0.9951 3212908 TimTec1_005485 Clc1ccc(Oc2ccc(/N=C/c3ccc(I)o3)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J08 compound treatment 110200.0 -21000.0 -0.81 116880.0 -33500.0 -1.26 -1.4636 -0.9779 3212909 TimTec1_005486 CC(=O)NC1=NC(=O)/C(=C\c2ccc(C)cc2)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J09 compound treatment 88480.0 -42700.0 -1.66 98800.0 -51500.0 -1.93 -2.5393 -0.997 3086311 TimTec1_005487 CCn1c2ccccc2c3cc(/C=N/c4ccc(Cl)cc4)ccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J10 compound treatment 114200.0 -17000.0 -0.66 135040.0 -15300.0 -0.57 -0.8719 -0.9977 1618704 TimTec1_005488 Cc1cc(=O)oc2c(C)c(O)c(CC=C)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J11 compound treatment 120160.0 -11000.0 -0.43 121640.0 -28700.0 -1.08 -1.064 -0.918 1654232 TimTec1_005489 CN(CP(=O)(O)CN1CCOCC1)S(=O)(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J12 compound treatment 117560.0 -13600.0 -0.53 124320.0 -26000.0 -0.98 -1.0642 -0.9583 3212910 TimTec1_005490 Clc1ccc(cc1)N2C(=C)C3(CCCCC3)OC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J13 compound treatment 111040.0 -20100.0 -0.78 120000.0 -30300.0 -1.14 -1.3577 -0.9831 3212911 TimTec1_005491 OCCn/1c(cs\c1=N/c2ccccc2)c3cccc(c3)N4C(=O)c5ccccc5C4=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J14 compound treatment 8880.0 -122000.0 -4.74 10360.0 -140000.0 -5.25 -7.0703 -0.9987 3086315 TimTec1_005492 OCCn/1c(cs\c1=N/c2cccc(c2)C(F)(F)F)c3ccc(cc3)S(=O)(=O)N4CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J15 compound treatment 94440.0 -36700.0 -1.43 100520.0 -49800.0 -1.87 -2.3302 -0.991 1655602 TimTec1_005493 CCOC(=O)C(Cc1ccc(NC(=O)c2ccccc2)cc1)N3C(=O)c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J16 compound treatment 119960.0 -11200.0 -0.43 137560.0 -12800.0 -0.48 -0.647 -0.9988 1386199 TimTec1_005494 CC1(C)OC(=O)N(CCCC(=O)O)C1(C)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J17 compound treatment 75480.0 -55700.0 -2.16 83560.0 -66800.0 -2.51 -3.3004 -0.9973 1068676 TimTec1_005495 Cc1ccc(cc1)S(=O)(=O)C=C(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J18 compound treatment 108480.0 -22700.0 -0.88 110880.0 -39500.0 -1.48 -1.67 -0.9691 3086318 TimTec1_005496 CCOC(=O)C1=C(NC(=S)NC1c2cccc(OC)c2O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J19 compound treatment 126320.0 -4850.0 -0.19 136760.0 -13600.0 -0.51 -0.4937 -0.9082 1433302 TimTec1_005497 COc1cccc(c1)c2nn(CN3CCCC3)c(=S)n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J20 compound treatment 124400.0 -6770.0 -0.26 126920.0 -23400.0 -0.88 -0.8075 -0.8799 3212912 TimTec1_005498 COc1ccc(CN(C2CC(=O)N(C2=O)c3ccccc3)C(=O)/C=C/C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J21 compound treatment 133320.0 2150.0 0.08 126840.0 -23500.0 -0.88 -0.5649 -0.6374 3086320 TimTec1_005499 CCOC(=O)c1c(/N=C/c2c(O)ccc3ccccc23)sc4CCCc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J22 compound treatment 112880.0 -18300.0 -0.71 123280.0 -27100.0 -1.02 -1.2202 -0.9846 3212913 TimTec1_005500 CCOc1cc(/C=c/2\sc3nc4c(C)c(C)ccc4n3c2=O)cc(Cl)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J23 mock treatment 115400.0 -15800.0 -0.61 134280.0 -16100.0 -0.6 -0.8591 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 J24 mock treatment 124200.0 -6970.0 -0.27 187880.0 37500.0 1.41 0.8048 0.5611 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K01 compound treatment 134280.0 3110.0 0.12 172240.0 21900.0 0.82 0.6663 0.8023 1526103 TimTec1_005501 CC(=O)Oc1ccc2oc(c(C(=O)O)c2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K02 compound treatment 142720.0 11500.0 0.45 112800.0 -37500.0 -1.41 -0.6796 -0.4596 1186869 TimTec1_005502 COc1ccccc1C(=O)Nc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K03 compound treatment 9480.0 -122000.0 -4.72 10800.0 -140000.0 -5.24 -7.0422 -0.9987 3212914 TimTec1_005503 O=C(NC(=S)NC1CCCC1)/C=C/c2ccc3OCOc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K04 compound treatment 157600.0 26400.0 1.03 123680.0 -26700.0 -1.0 0.0173 0.0121 3086394 TimTec1_005504 Cc1ccc(cc1)S(=O)(=O)N=C2NCN(CN2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K05 compound treatment 126600.0 -4570.0 -0.18 120920.0 -29400.0 -1.1 -0.9064 -0.8103 1131736 TimTec1_005505 COc1ccc(cc1OC)c2c(C)nn(c2NC(=O)C)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K06 compound treatment 98640.0 -32500.0 -1.26 97600.0 -52700.0 -1.98 -2.2924 -0.9764 1007406 TimTec1_005506 COc1ccc(OC(=O)c2ccc(Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K07 compound treatment 108400.0 -22800.0 -0.88 122160.0 -28200.0 -1.06 -1.3728 -0.996 3212915 TimTec1_005507 Clc1ccccc1C(=O)N=C2NCCCCCN2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K08 compound treatment 75200.0 -56000.0 -2.17 96360.0 -54000.0 -2.03 -2.9684 -0.9994 1323784 TimTec1_005508 Cc1cccc(c1)S(=O)(=O)N2CCSC2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K09 compound treatment 118120.0 -13100.0 -0.51 121040.0 -29300.0 -1.1 -1.1359 -0.938 1116167 TimTec1_005509 Cn1c(=O)n(C)c2nc(Br)n(CC(=O)c3ccccc3)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K10 compound treatment 106240.0 -24900.0 -0.97 117680.0 -32700.0 -1.23 -1.551 -0.9931 1464973 TimTec1_005510 OC(=O)c1cc(c2ccccc2)c(cn1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K11 compound treatment 9760.0 -121000.0 -4.71 11640.0 -139000.0 -5.21 -7.0122 -0.9988 3212916 TimTec1_005511 Cc1ccc2nc(Nc3ccc(Cl)cc3)c(/C=N/O)c(=O)n2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K12 compound treatment 90240.0 -40900.0 -1.59 84280.0 -66100.0 -2.48 -2.8764 -0.9768 3086399 TimTec1_005512 Cc1cccc2nc3/C(=N\c4ccccc4)/c5ccccc5-c3nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K13 compound treatment 102960.0 -28200.0 -1.09 112920.0 -37400.0 -1.4 -1.7673 -0.9924 1486848 TimTec1_005513 CCCc1cc2c(=O)c(coc2cc1O)c3nc4ccccc4n3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K14 compound treatment 117200.0 -14000.0 -0.54 122720.0 -27600.0 -1.04 -1.1165 -0.9542 3086401 TimTec1_005514 CSc1cccc2c(SC)cccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K15 compound treatment 31200.0 -100000.0 -3.88 35600.0 -115000.0 -4.31 -5.7881 -0.9986 3212917 TimTec1_005515 C(N1CCN(CC1)/N=C/c2ccncc2)c3cccc4ccccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K16 compound treatment 110960.0 -20200.0 -0.78 126440.0 -23900.0 -0.9 -1.189 -0.9977 3086404 TimTec1_005516 O=c1/c(=C/C=C/c2ccccc2)/sc3nc4ccccc4n13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K17 compound treatment 92280.0 -38900.0 -1.51 131200.0 -19100.0 -0.72 -1.5752 -0.9425 1919931 TimTec1_005517 Sc1nnc(o1)C2(CCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K18 compound treatment 96880.0 -34300.0 -1.33 135120.0 -15200.0 -0.57 -1.345 -0.9288 3212918 TimTec1_005518 Cc1ccc(cc1)C2=C/C(=C/c3c(O)ccc4ccccc34)/C(=O)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K19 compound treatment 103880.0 -27300.0 -1.06 99040.0 -51300.0 -1.93 -2.1104 -0.9603 3086406 TimTec1_005519 COc1ccc(cc1)N2C(=O)CC(S/C(=N/c3ccccc3)/N)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K20 compound treatment 118520.0 -12700.0 -0.49 124480.0 -25900.0 -0.97 -1.0336 -0.9501 3212919 TimTec1_005520 COc1ccc(OCCNS(=O)(=O)c2ccc3c(c2)oc4ccccc43)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K21 compound treatment 9400.0 -122000.0 -4.72 10160.0 -140000.0 -5.26 -7.0614 -0.9986 3086408 TimTec1_005521 Cc1ccccc1C2C(=C(N)SC(=C2C#N)N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K22 compound treatment 13520.0 -118000.0 -4.56 21680.0 -129000.0 -4.83 -6.6426 -0.9996 3212920 TimTec1_005522 COc1ccc(cc1)C(=O)[C@@H]2[C@@H](c3ccccc3F)C(C#N)(C#N)[C@H]4C=Cc5ccccc5N24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K23 mock treatment 120720.0 -10500.0 -0.41 142760.0 -7590.0 -0.28 -0.4881 -0.9851 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 K24 mock treatment 120200.0 -11000.0 -0.43 176160.0 25800.0 0.97 0.384 0.3629 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L01 compound treatment 109200.0 -22000.0 -0.85 155000.0 4650.0 0.17 -0.4794 -0.5509 3212921 TimTec1_005523 Oc1ccc(Br)cc1/C=N/c2ccc3nc(SCC(=O)Nc4ccccc4)sc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L02 compound treatment 105640.0 -25500.0 -0.99 96560.0 -53800.0 -2.02 -2.128 -0.9463 3086411 TimTec1_005524 Fc1cccc(c1)N2C(=O)/C(=C/C=C/c3ccccc3)/SC2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L03 compound treatment 6640.0 -125000.0 -4.83 6720.0 -144000.0 -5.39 -7.2284 -0.9985 3086413 TimTec1_005525 NC1=C(C#N)C(c2ccsc2)c3ccc4ccccc4c3O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L04 compound treatment 7320.0 -124000.0 -4.81 8280.0 -142000.0 -5.33 -7.1683 -0.9987 1682053 TimTec1_005526 Cc1ccc2nc(cn2c1)c3ccc(O)c(O)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L05 compound treatment 14360.0 -117000.0 -4.53 35680.0 -115000.0 -4.3 -6.248 -0.9997 1536268 TimTec1_005527 Cc1ccc(cc1)N2C(=C(C#N)C(C3=C2CC(C)(C)CC3=O)c4ccccc4)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L06 compound treatment 123640.0 -7530.0 -0.29 128920.0 -21400.0 -0.8 -0.7753 -0.9061 3211217 TimTec1_005528 CC1(C)NN1CCCN2NC2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L07 compound treatment 43720.0 -87500.0 -3.39 60200.0 -90100.0 -3.38 -4.7918 -1.0 1273515 TimTec1_005529 OC(=O)c1cc(Cl)c(Cl)cc1C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L08 compound treatment 97280.0 -33900.0 -1.31 122240.0 -28100.0 -1.05 -1.6758 -0.994 1548568 TimTec1_005530 C=CCNC(=O)C1CC1(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L09 compound treatment 46080.0 -85100.0 -3.3 51280.0 -99100.0 -3.72 -4.9637 -0.9982 3211218 TimTec1_005531 Cc1ccc2nc(sc2c1)c3ccc(/N=C\c4ccc[nH]4)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L10 compound treatment 119920.0 -11300.0 -0.44 122040.0 -28300.0 -1.06 -1.06 -0.9228 1209920 TimTec1_005532 OCN1C(C(=C(O)C1=O)C(=O)c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L11 compound treatment 116440.0 -14700.0 -0.57 120560.0 -29800.0 -1.12 -1.1947 -0.9515 1148781 TimTec1_005533 CCN(CC)C(=O)c1ccc(o1)C(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L12 compound treatment 9320.0 -122000.0 -4.73 11240.0 -139000.0 -5.22 -7.0349 -0.9988 3211219 TimTec1_005534 CCc1c(C)[nH]c(C(=O)OCc2ccccc2)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L13 compound treatment 118200.0 -13000.0 -0.5 116480.0 -33900.0 -1.27 -1.2547 -0.9178 1175161 TimTec1_005535 O=P(CCN1CCOCC1)(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L14 compound treatment 118800.0 -12400.0 -0.48 130480.0 -19900.0 -0.75 -0.8667 -0.9773 3086492 TimTec1_005536 OC(=O)c1ccc(/N=C/c2ccc(OC(=O)c3sc4ccccc4c3Cl)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L15 compound treatment 93680.0 -37500.0 -1.45 104640.0 -45700.0 -1.72 -2.2417 -0.9966 3211220 TimTec1_005537 CCOC(=O)CC1=C(C#N)C(C(=C(N)O1)C(=O)OCC)c2cccnc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L16 compound treatment 13840.0 -117000.0 -4.55 23320.0 -127000.0 -4.77 -6.5903 -0.9997 1174009 TimTec1_005538 CCCSc1nnc2c3ccccc3n(Cc4ccccc4)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L17 compound treatment 27280.0 -104000.0 -4.03 49920.0 -100000.0 -3.77 -5.5156 -0.9994 3211221 TimTec1_005539 COc1cc(/C=C/2\S/C(=N\c3ccccc3)/N(C2=O)c4ccccc4)cc(OC)c1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L18 compound treatment 114240.0 -16900.0 -0.66 116400.0 -33900.0 -1.27 -1.3655 -0.9525 3211222 TimTec1_005540 CC(=O)N1c2ccccc2C3=NNC(=S)NC13O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L19 compound treatment 119160.0 -12000.0 -0.47 128680.0 -21700.0 -0.81 -0.9046 -0.9651 3086496 TimTec1_005541 COc1cc(/C=N/c2ccc(\N=C\c3ccc(OC(=O)C)c(OC)c3)cc2)ccc1OC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L20 compound treatment 72480.0 -58700.0 -2.28 102000.0 -48300.0 -1.81 -2.8934 -0.9937 3211223 TimTec1_005542 O=C/1N(C2CCCC2)/C(=N\c3ccccc3)/S\C1=C\c4c[nH]c5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L21 compound treatment 11360.0 -120000.0 -4.65 33320.0 -117000.0 -4.39 -6.3929 -0.9996 1270230 TimTec1_005543 COC(=O)C1=C(N)N(C2=C(C1c3ccc(OC)cc3)C(=O)CCC2)c4ccc(C)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L22 compound treatment 93360.0 -37800.0 -1.47 106800.0 -43500.0 -1.63 -2.1931 -0.9985 3086498 TimTec1_005544 CC(C)/C=N/N1C(C(C)C)C(C#N)(C#N)C(=C1N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L23 mock treatment 115240.0 -15900.0 -0.62 129920.0 -20400.0 -0.77 -0.9792 -0.9943 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 L24 mock treatment 124440.0 -6730.0 -0.26 170080.0 19700.0 0.74 0.339 0.4317 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M01 compound treatment 3640.0 -128000.0 -4.95 6040.0 -144000.0 -5.42 -7.3287 -0.999 1414805 TimTec1_005545 CC(NC(=O)OCc1ccccc1)C(=O)Oc2cc3oc(=O)c(Cl)c(C)c3cc2Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M02 compound treatment 9040.0 -122000.0 -4.74 11160.0 -139000.0 -5.22 -7.0447 -0.9988 3086501 TimTec1_005546 CCOC(=O)C1=C(CSc2nc(CC)c(C)cc2C#N)OC(=C(C#N)C1c3ccc(F)cc3)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M03 compound treatment 138160.0 6990.0 0.27 114240.0 -36100.0 -1.36 -0.7665 -0.5546 1514197 TimTec1_005547 Cc1cccc(NCN2C(=O)CSC2=O)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M04 compound treatment 157400.0 26200.0 1.02 125400.0 -24900.0 -0.94 0.0575 0.0416 1084346 TimTec1_005548 CCOC(=O)Cc1nc2ccccc2[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M05 compound treatment 13000.0 -118000.0 -4.59 18920.0 -131000.0 -4.93 -6.7301 -0.9993 1367503 TimTec1_005549 CC(C)C(NS(=O)(=O)c1ccc(C)cc1)C(=O)Oc2ccc3c4CCCCc4c(=O)oc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M06 compound treatment 101760.0 -29400.0 -1.14 123800.0 -26500.0 -1.0 -1.5115 -0.9977 1003422 TimTec1_005550 CC(=O)Oc1ccc(cc1)C(=O)c2ccc(OC(=O)C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M07 compound treatment 44200.0 -87000.0 -3.37 69520.0 -80800.0 -3.03 -4.5312 -0.9986 3085493 TimTec1_005551 CC1=C(N(N/C(=N\CC=C)/S1)c2ccc3OCCOc3c2)C(=O)Nc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M08 compound treatment 103720.0 -27500.0 -1.07 123120.0 -27200.0 -1.02 -1.4758 -0.9998 1442839 TimTec1_005552 OCCN1CCN(CC1)C(=O)Nc2cccc(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M09 compound treatment 115000.0 -16200.0 -0.63 125640.0 -24700.0 -0.93 -1.0994 -0.9819 1468923 TimTec1_005553 CCOC(=O)c1c(N)cc2[nH]c(=S)[nH]c(=O)c2c1c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M10 compound treatment 30440.0 -101000.0 -3.91 71160.0 -79200.0 -2.97 -4.8652 -0.9909 3085496 TimTec1_005554 Cc1ccccc1c2nccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M11 compound treatment 114560.0 -16600.0 -0.64 126560.0 -23800.0 -0.89 -1.0871 -0.9872 1298715 TimTec1_005555 CCOC(=O)NS(=O)(=O)c1ccc(C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M12 compound treatment 61960.0 -69200.0 -2.69 76120.0 -74200.0 -2.79 -3.8688 -0.9998 3211224 TimTec1_005556 Cc1ccc-2c(c1)/C(=C/c3ccncc3)/c4cc5ccccc5nc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M13 compound treatment 110280.0 -20900.0 -0.81 125120.0 -25200.0 -0.95 -1.2427 -0.997 1313295 TimTec1_005557 Cc1c(OCC(=O)OCc2ccccc2)ccc3c4ccccc4c(=O)oc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M14 compound treatment 100680.0 -30500.0 -1.18 106760.0 -43600.0 -1.64 -1.9933 -0.9873 1489666 TimTec1_005558 COC(=O)C(C)N(C(=O)c1c(F)cccc1F)c2c(C)cccc2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M15 compound treatment 51600.0 -79600.0 -3.09 62440.0 -87900.0 -3.3 -4.5161 -0.9994 1632514 TimTec1_005559 Clc1ccccc1N2C(=O)CC(Nc3ccccc3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M16 compound treatment 6920.0 -124000.0 -4.82 8840.0 -142000.0 -5.31 -7.1644 -0.9988 3085499 TimTec1_005560 CCOC(=O)CSC1=NC(=O)/C(=C\c2ccc(Cl)cc2)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M17 compound treatment 113920.0 -17300.0 -0.67 117640.0 -32700.0 -1.23 -1.3414 -0.9593 3211225 TimTec1_005561 CC1(C)OC(=O)N(Cc2ccccc2)C1=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M18 compound treatment 101560.0 -29600.0 -1.15 119800.0 -30500.0 -1.15 -1.6231 -1.0 1242728 TimTec1_005562 Cc1ccc(NS(=O)(=O)c2ccc(cc2)N3C(=O)c4ccccc4C3=O)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M19 compound treatment 10840.0 -120000.0 -4.67 35680.0 -115000.0 -4.3 -6.3446 -0.9992 1175444 TimTec1_005563 CCOc1ccc2nc(SCc3c[nH]c4ccccc34)sc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M20 compound treatment 116400.0 -14800.0 -0.57 115840.0 -34500.0 -1.3 -1.3211 -0.9328 1133231 TimTec1_005564 Cc1[nH]c(=O)[nH]c(=O)c1S(=O)(=O)NCc2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M21 compound treatment 94080.0 -37100.0 -1.44 118160.0 -32200.0 -1.21 -1.8719 -0.9962 3085503 TimTec1_005565 COc1cc(/C=N/c2c(nc3ccccn23)c4ccc(O)c(OC)c4)ccc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M22 compound treatment 63920.0 -67300.0 -2.61 76640.0 -73700.0 -2.77 -3.8012 -0.9996 3211226 TimTec1_005566 CC(=O)N1CC=C2[C@H](C1)[C@@H](c3ccc(F)cc3F)C(C#N)(C#N)C(=C2C#N)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M23 mock treatment 122040.0 -9130.0 -0.35 169920.0 19600.0 0.73 0.2689 0.3297 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 M24 mock treatment 130400.0 -771.0 -0.03 178920.0 28600.0 1.07 0.7371 0.6871 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N01 compound treatment 3560.0 -128000.0 -4.95 4840.0 -146000.0 -5.46 -7.3628 -0.9988 2116249 TimTec1_005567 O=C/1NC(=S)N(C(=O)\C1=C\c2c[nH]c3ccccc23)c4cccc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N02 compound treatment 126120.0 -5050.0 -0.2 163080.0 12700.0 0.48 0.1993 0.3859 1630568 TimTec1_005568 CC(=Cc1c(O)nc2ccccn2c1=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N03 compound treatment 59080.0 -72100.0 -2.8 74960.0 -75400.0 -2.83 -3.9786 -1.0 1455275 TimTec1_005569 CCOC(=O)CCC1(CCC(=O)OCC)c2ccccc2-c3nc4ccccc4cc31 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N04 compound treatment 118120.0 -13100.0 -0.51 123720.0 -26600.0 -1.0 -1.0648 -0.9504 1423540 TimTec1_005570 CCNC(=O)C1CN(C(=O)C1)c2ccc(C)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N05 compound treatment 63000.0 -68200.0 -2.65 105160.0 -45200.0 -1.7 -3.0696 -0.9769 3211227 TimTec1_005571 S/C(=C(/C(=O)c1ccccc1)\[n+]2ccccc2)/Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N06 compound treatment 66080.0 -65100.0 -2.53 98160.0 -52200.0 -1.96 -3.1709 -0.9921 3085508 TimTec1_005572 CCOC(=O)Cn/1c(cs\c1=N/c2ccc(F)cc2)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N07 compound treatment 83360.0 -47800.0 -1.86 126080.0 -24300.0 -0.91 -1.9558 -0.9464 3211228 TimTec1_005573 S=c1[nH]nc([nH]1)C2CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N08 compound treatment 84880.0 -46300.0 -1.8 124480.0 -25900.0 -0.97 -1.9566 -0.9583 1670836 TimTec1_005574 COc1ccc2C(=O)C(CCc2c1C)C3(O)C(=O)N(C)c4ccccc43 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N09 compound treatment 68200.0 -63000.0 -2.44 106720.0 -43600.0 -1.64 -2.8855 -0.9811 2116264 TimTec1_005575 Cc1[nH]c2ccccc2c1/C=N/c3ccc(\N=C\c4c(C)[nH]c5ccccc45)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N10 compound treatment 112520.0 -18700.0 -0.72 121240.0 -29100.0 -1.09 -1.2842 -0.98 1703166 TimTec1_005576 Cn1c(SCC(=O)N2CCCCC2)nc3n(C)c(=O)n(C)c(=O)c13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N11 compound treatment 96680.0 -34500.0 -1.34 114880.0 -35500.0 -1.33 -1.8876 -1.0 3211229 TimTec1_005577 COc1ccc(cc1)n2nc(C#N)c(N)c(C#N)c2=N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N12 compound treatment 108560.0 -22600.0 -0.88 118240.0 -32100.0 -1.21 -1.4725 -0.9878 3085531 TimTec1_005578 O=C(Cn1nnc2ccccc12)C3CC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N13 compound treatment 34720.0 -96500.0 -3.74 36320.0 -114000.0 -4.28 -5.6724 -0.9978 1157884 TimTec1_005579 Cc1ccc(cc1C)c2csc(Nc3ccc4OCOc4c3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N14 compound treatment 112280.0 -18900.0 -0.73 111200.0 -39100.0 -1.47 -1.5573 -0.9484 1380401 TimTec1_005580 CCOc1ccc(cc1)N2C(=O)CC(N(Cc3ccc(Cl)cc3)C(=O)c4ccc(Cl)cc4)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N15 compound treatment 94240.0 -36900.0 -1.43 118400.0 -31900.0 -1.2 -1.8611 -0.9961 3085535 TimTec1_005581 OC(=O)CN1C(=O)/C(=C\c2ccsc2)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N16 compound treatment 71120.0 -60100.0 -2.33 71920.0 -78400.0 -2.94 -3.729 -0.9933 3211425 TimTec1_005582 Oc1ccccc1/C=N/c2ccc3nc(SCC(=O)NCCOc4ccccc4)sc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N17 compound treatment 93840.0 -37300.0 -1.45 118920.0 -31400.0 -1.18 -1.8583 -0.9948 1583377 TimTec1_005583 CC1CN(CN2C(=O)c3ccccc3C2=O)CC(C)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N18 compound treatment 103880.0 -27300.0 -1.06 115760.0 -34600.0 -1.3 -1.6667 -0.9949 1137144 TimTec1_005584 Nc1nnc(CCN2CCCCC2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N19 compound treatment 102080.0 -29100.0 -1.13 118560.0 -31800.0 -1.19 -1.6418 -0.9996 3211426 TimTec1_005585 CC1=C(C(NC(=O)N1)c2ccc3OCOc3c2)C(=O)OCC(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N20 compound treatment 87200.0 -44000.0 -1.71 114560.0 -35800.0 -1.34 -2.1562 -0.993 3211427 TimTec1_005586 COc1cc(/C=C\2/S/C(=N/Cc3ccccc3)/N(Cc4ccccc4)C2=O)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N21 compound treatment 39880.0 -91300.0 -3.54 76800.0 -73500.0 -2.76 -4.4566 -0.9924 3085538 TimTec1_005587 Cc1ccc(/C=N/c2ccc(Nc3ccccc3)cc2)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N22 compound treatment 7440.0 -124000.0 -4.8 10120.0 -140000.0 -5.26 -7.1162 -0.9989 1176605 TimTec1_005588 Fc1ccc(cc1)c2nc3c([nH]2)c4ccccc4c5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N23 mock treatment 137200.0 6030.0 0.23 173920.0 23600.0 0.88 0.791 0.8644 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 N24 mock treatment 148760.0 17600.0 0.68 171160.0 20800.0 0.78 1.0349 0.9977 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O01 compound treatment 6200.0 -125000.0 -4.85 5840.0 -145000.0 -5.42 -7.2638 -0.9984 1527225 TimTec1_005589 CCc1cc2c(=O)c(c3nc4ccccc4[nH]3)c(C)oc2cc1O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O02 compound treatment 4440.0 -127000.0 -4.92 5560.0 -145000.0 -5.43 -7.3195 -0.9988 3085541 TimTec1_005590 NC1=C(C#N)C2=CCSC[C@H]2[C@H](c3cccc(Cl)c3)C1(C#N)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O03 compound treatment 85640.0 -45500.0 -1.77 105440.0 -44900.0 -1.69 -2.441 -0.9997 1190084 TimTec1_005591 CCOc1ccccc1C(=O)NCCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O04 compound treatment 113480.0 -17700.0 -0.69 134560.0 -15800.0 -0.59 -0.9044 -0.9973 1047189 TimTec1_005592 Clc1ccc(cc1)S(=O)(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O05 compound treatment 40880.0 -90300.0 -3.5 80120.0 -70200.0 -2.64 -4.341 -0.9902 3211428 TimTec1_005593 CC(C)(C)OC(=O)C1CCC(CN1)C(=O)Oc2ccc3c4CCCCc4c(=O)oc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O06 compound treatment 102680.0 -28500.0 -1.11 141240.0 -9110.0 -0.34 -1.0234 -0.8845 1652072 TimTec1_005594 COC(=O)C1C(C(C(=O)OC)C(C)(O)CC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O07 compound treatment 87360.0 -43800.0 -1.7 148840.0 -1510.0 -0.06 -1.242 -0.7303 3211429 TimTec1_005595 Clc1cccc(NC(=O)N=C2NCCCCCN2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O08 compound treatment 93560.0 -37600.0 -1.46 131920.0 -18400.0 -0.69 -1.521 -0.9418 1649723 TimTec1_005596 CC(C)CN1C(=O)N(C(n2oc(=O)n(c3ccccc3)c2=O)C1(C)C)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O09 compound treatment 79600.0 -51600.0 -2.0 127920.0 -22400.0 -0.84 -2.0101 -0.926 1511407 TimTec1_005597 CCc1c(C)c(C#N)c2nc3ccccc3n2c1NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O10 compound treatment 27560.0 -104000.0 -4.02 29040.0 -121000.0 -4.55 -6.0621 -0.9981 3085546 TimTec1_005598 Cc1ccccc1c2ccc3cccc(C)c3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O11 compound treatment 36760.0 -94400.0 -3.66 64680.0 -85700.0 -3.22 -4.8638 -0.9979 3211430 TimTec1_005599 S(c1nnc[nH]1)c2nc3ccccc3nc2Sc4nnc[nH]4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O12 compound treatment 86920.0 -44300.0 -1.72 121960.0 -28400.0 -1.07 -1.9675 -0.9737 1067246 TimTec1_005600 COc1ccc(C)c2C(=O)CCCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O13 compound treatment 92760.0 -38400.0 -1.49 106400.0 -43900.0 -1.65 -2.2202 -0.9987 1520144 TimTec1_005601 CC(NC(=O)OCc1ccccc1)C(=O)Oc2ccc3c(=O)c(coc3c2)c4ccc(F)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O14 compound treatment 15520.0 -116000.0 -4.49 20880.0 -129000.0 -4.86 -6.609 -0.9992 1641803 TimTec1_005602 Clc1cc(OC(=O)C2CCCCC2)ccc1OC(=O)C3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O15 compound treatment 5720.0 -125000.0 -4.87 11000.0 -139000.0 -5.23 -7.14 -0.9994 3211431 TimTec1_005603 OC1=C(C#N)[C@@H]([C@H](C(=O)N1CCc2ccccc2)[n+]3ccccc3)c4ccc(Cl)cc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O16 compound treatment 71640.0 -59500.0 -2.31 104560.0 -45800.0 -1.72 -2.8485 -0.9894 1578376 TimTec1_005604 Cc1cc(=O)oc2cc(OC(=O)c3cc4ccccc4o3)ccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O17 compound treatment 81720.0 -49500.0 -1.92 112400.0 -37900.0 -1.42 -2.3639 -0.9892 3211432 TimTec1_005605 CCc1nc(SC/C=C/c2ccccc2)c(C#N)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O18 compound treatment 70360.0 -60800.0 -2.36 115000.0 -35300.0 -1.33 -2.6065 -0.9629 1218415 TimTec1_005606 CCOC(=O)C1=C(C)NC(=S)NC1c2ccc(OCC(=O)N3CCCCC3)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O19 compound treatment 5920.0 -125000.0 -4.86 8640.0 -142000.0 -5.32 -7.1972 -0.999 1784221 TimTec1_005607 CCc1oc2ccccc2c1C(=O)CCN3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O20 compound treatment 72200.0 -59000.0 -2.29 116240.0 -34100.0 -1.28 -2.5231 -0.9623 3085555 TimTec1_005608 Cc1c(Cl)cccc1NC2=NS(=O)(=O)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O21 compound treatment 115560.0 -15600.0 -0.61 129240.0 -21100.0 -0.79 -0.9885 -0.9912 1638741 TimTec1_005609 CC(C)NC(=O)C1CN(CCN1S(=O)(=O)c2ccccc2)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O22 compound treatment 83760.0 -47400.0 -1.84 116480.0 -33900.0 -1.27 -2.1996 -0.9837 3211433 TimTec1_005610 COc1ccc(cc1)C(=O)CSc2nsc(SCC(=O)c3ccc(OC)cc3)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O23 mock treatment 125560.0 -5610.0 -0.22 164040.0 13700.0 0.51 0.2094 0.3752 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 O24 mock treatment 152640.0 21500.0 0.83 177720.0 27400.0 1.03 1.3154 0.9946 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P01 compound treatment 43040.0 -88100.0 -3.42 19400.0 -131000.0 -4.91 -5.8932 -0.9843 3085557 TimTec1_005611 Oc1ccc(Br)cc1/C=N/CC2CCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P02 compound treatment 79760.0 -51400.0 -1.99 80760.0 -69600.0 -2.61 -3.2573 -0.9911 1175377 TimTec1_005612 Sc1nnc2c3ccccc3n(Cc4ccccc4)c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P03 compound treatment 93600.0 -37600.0 -1.46 90520.0 -59800.0 -2.25 -2.6186 -0.9781 3211434 TimTec1_005613 Cc1ccccc1c2nnc3-c4ccccc4CC(C)(C)n23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P04 compound treatment 15240.0 -116000.0 -4.5 44600.0 -106000.0 -3.97 -5.9871 -0.9981 1673398 TimTec1_005614 CCCC1C(C2c3ccccc3C1c4ccccc24)C(=O)Nc5ccccc5OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P05 compound treatment 105680.0 -25500.0 -0.99 117200.0 -33100.0 -1.24 -1.5791 -0.9935 1642050 TimTec1_005615 N#Cc1ccc(cc1C#N)n2nnc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P06 compound treatment 92040.0 -39100.0 -1.52 120000.0 -30300.0 -1.14 -1.879 -0.99 1492547 TimTec1_005616 CC1(C)CC(=O)c2cc(c3ccc(Br)cc3)n(CC(=O)O)c2C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P07 compound treatment 104680.0 -26500.0 -1.03 125920.0 -24400.0 -0.92 -1.3751 -0.9984 3085561 TimTec1_005617 Oc1ccc(/C=N/c2ccc3[nH]c(=O)[nH]c3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P08 compound treatment 5480.0 -126000.0 -4.88 8160.0 -142000.0 -5.34 -7.222 -0.999 3211435 TimTec1_005618 CCOc1ccc2ccccc2c1/C=C/3\C(=O)NC(=S)N(C3=O)c4cccc(Cl)c4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P09 compound treatment 85160.0 -46000.0 -1.79 108440.0 -41900.0 -1.57 -2.3746 -0.998 3085562 TimTec1_005619 COc1cccc(c1)c2nnc(SCC(=O)NCCOc3ccccc3)n2c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P10 compound treatment 101000.0 -30200.0 -1.17 115520.0 -34800.0 -1.31 -1.7521 -0.9985 3211436 TimTec1_005620 Cn1cnnc1SCN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P11 compound treatment 95520.0 -35700.0 -1.38 107800.0 -42500.0 -1.6 -2.1073 -0.9974 1443624 TimTec1_005621 CCOP(=O)(C)C1(CC1)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P12 compound treatment 82800.0 -48400.0 -1.88 107120.0 -43200.0 -1.62 -2.4743 -0.9974 1354424 TimTec1_005622 CCN(CC)C(=O)C1(CC1)P(=O)(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P13 compound treatment 89120.0 -42100.0 -1.63 113960.0 -36400.0 -1.37 -2.1194 -0.9961 1466364 TimTec1_005623 COCc1cc(C)c2c(n1)sc3c4nc5ccccc5n4c(C)nc32 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P14 compound treatment 50400.0 -80800.0 -3.13 68640.0 -81700.0 -3.07 -4.3845 -0.9999 3211437 TimTec1_005624 C=CCN/1C(=O)/C(=C\c2cccs2)/S\C1=N\c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P15 compound treatment 72040.0 -59100.0 -2.29 93360.0 -57000.0 -2.14 -3.1347 -0.9994 1444037 TimTec1_005625 Nc1nc(CCc2ccccc2)c(C#N)c(N)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P16 compound treatment 34160.0 -97000.0 -3.76 50880.0 -99500.0 -3.73 -5.3014 -1.0 3085567 TimTec1_005626 COc1ccc2NC(=O)/C(=C/3\SC(=S)NC3=O)/c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P17 compound treatment 3920.0 -127000.0 -4.94 5320.0 -145000.0 -5.44 -7.3402 -0.9988 1603829 TimTec1_005627 Nc1nc(CSc2nc3ccccc3s2)nc(Nc4ccccc4)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P18 compound treatment 61680.0 -69500.0 -2.7 86640.0 -63700.0 -2.39 -3.5973 -0.9982 1171831 TimTec1_005628 Cc1ccc(Nc2nc(C)nc3c4ccccc4oc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P19 compound treatment 97120.0 -34100.0 -1.32 109880.0 -40500.0 -1.52 -2.0082 -0.9976 1524350 TimTec1_005629 COC(=O)c1ccc(NC(=O)Cn2nc(SC)n(N)c2=S)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P20 compound treatment 5440.0 -126000.0 -4.88 10360.0 -140000.0 -5.25 -7.1647 -0.9993 3211438 TimTec1_005630 CCOC(=O)/C=C/c1ccco1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P21 compound treatment 65520.0 -65700.0 -2.55 76120.0 -74200.0 -2.79 -3.7711 -0.999 3211439 TimTec1_005631 CCOC(=O)C1C2NC(=S)N[C@]1(C)Oc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P22 compound treatment 113040.0 -18100.0 -0.7 131360.0 -19000.0 -0.71 -1.0014 -1.0 3085589 TimTec1_005632 COc1cc(/C=C\2/C(=NN(C2=O)c3ccc(Cl)c(c3)C(=O)O)C)ccc1OCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P23 mock treatment 129880.0 -1290.0 -0.05 148120.0 -2230.0 -0.08 -0.0946 -0.9699 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2078 P24 mock treatment 124360.0 -6810.0 -0.26 135840.0 -14500.0 -0.54 -0.5719 -0.9449 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A01 compound treatment 123840.0 8910.0 0.35 136360.0 -5440.0 -0.2 0.1001 0.2493 3211440 TimTec1_005633 CC(=O)n1cc(/C=c\2/sc3nc4c(C)c(C)ccc4n3c2=O)c(n1)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A02 compound treatment 6240.0 -109000.0 -4.22 5400.0 -136000.0 -5.12 -6.6019 -0.9954 3085592 TimTec1_005634 Cc1nc(N)sc1c2csc(Nc3cccc(Cl)c3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A03 compound treatment 179200.0 64300.0 2.49 164160.0 22400.0 0.84 2.3568 0.8957 3211529 TimTec1_005635 CCC(=O)N1N=C(CC1(O)c2ccc(F)cc2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A04 compound treatment 181920.0 67000.0 2.6 148520.0 6720.0 0.25 2.0163 0.7721 1419705 TimTec1_005636 CC1CCC(=C(C#N)C(=O)NCc2ccccc2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A05 compound treatment 39120.0 -75800.0 -2.94 7040.0 -135000.0 -5.06 -5.6563 -0.9667 1732858 TimTec1_005637 Fc1ccc2C(=O)N(C3CCCCCCC3)C(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A06 compound treatment 13880.0 -101000.0 -3.92 5760.0 -136000.0 -5.11 -6.3827 -0.9915 3211530 TimTec1_005638 Fc1ccc(cc1)C2Nc3ccc(OC(F)(F)F)cc3C4C=CCC42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A07 compound treatment 176120.0 61200.0 2.37 135680.0 -6120.0 -0.23 1.5164 0.6357 1737054 TimTec1_005639 Nn1c(CO)nc2ccccc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A08 compound treatment 161120.0 46200.0 1.79 147240.0 5440.0 0.2 1.4117 0.7826 1175030 TimTec1_005640 CC(C)(O)c1cn2ccccc2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A09 compound treatment 161120.0 46200.0 1.79 132560.0 -9240.0 -0.35 1.0221 0.5599 1364286 TimTec1_005641 COc1ccc(cc1)C(CC#N)C2CCOC(C)(C)C2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A10 compound treatment 171240.0 56300.0 2.18 132400.0 -9400.0 -0.35 1.2955 0.5853 1357576 TimTec1_005642 O=C(NCCc1ccc(cc1)S(=O)(=O)N2CCCC2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A11 compound treatment 47160.0 -67800.0 -2.63 11720.0 -130000.0 -4.88 -5.3115 -0.9578 3211531 TimTec1_005643 CNC(=S)N(C)/N=C\1/C(=O)N(Cc2c(Cl)cccc2Cl)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A12 compound treatment 173960.0 59000.0 2.29 179840.0 38000.0 1.43 2.6291 0.9741 3085598 TimTec1_005644 CCc1nn2c(C)cc(O)nc2c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A13 compound treatment 159560.0 44600.0 1.73 161040.0 19200.0 0.72 1.7351 0.9248 1530862 TimTec1_005645 C1Cc2c(C1)c3c(ccc4ccccc43)nc2c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A14 compound treatment 179360.0 64400.0 2.5 171920.0 30100.0 1.13 2.5671 0.9356 1575017 TimTec1_005646 CC1CN(OC(O1)c2ccc3OCOc3c2)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A15 compound treatment 167520.0 52600.0 2.04 150760.0 8960.0 0.34 1.6807 0.8126 3085600 TimTec1_005647 OC(=O)C1CC(=O)N(Cc2ccccc2)/C(=N/c3ccc(F)cc3)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A16 compound treatment 179840.0 64900.0 2.52 145160.0 3360.0 0.13 1.8701 0.7416 1628881 TimTec1_005648 CCC(N)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A17 compound treatment 169600.0 54700.0 2.12 118040.0 -23800.0 -0.89 0.8694 0.3778 3085602 TimTec1_005649 FC(F)(F)c1cccc(NCn2c(=S)oc3ccc(Cl)cc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A18 compound treatment 135640.0 20700.0 0.8 65680.0 -76100.0 -2.86 -1.4519 -0.4892 1127153 TimTec1_005650 CC(C)c1ccccc1NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A19 compound treatment 192240.0 77300.0 3.0 161320.0 19500.0 0.73 2.6392 0.8547 1348096 TimTec1_005651 CN(C)c1nc2n(C)c(=O)n(C)c(=O)c2n1CC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A20 compound treatment 181800.0 66900.0 2.59 163480.0 21700.0 0.81 2.41 0.8863 1611764 TimTec1_005652 COC(=O)CCn1cc(F)c(N)nc1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A21 compound treatment 188400.0 73500.0 2.85 178320.0 36500.0 1.37 2.985 0.9437 1564099 TimTec1_005653 CN(C)N=Nc1ccc(cc1)S(=O)(=O)NC(=O)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A22 compound treatment 180400.0 65500.0 2.54 174640.0 32800.0 1.23 2.6678 0.9448 1394944 TimTec1_005654 C=CCn1c(SCc2nc3ccccc3[nH]2)nnc1c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A23 mock treatment 176200.0 61300.0 2.38 172920.0 31100.0 1.17 2.5069 0.9464 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 A24 mock treatment 146680.0 31800.0 1.23 174240.0 32400.0 1.22 1.7321 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B01 compound treatment 171240.0 56300.0 2.18 151920.0 10100.0 0.38 1.8135 0.8177 3211532 TimTec1_005655 SC1=NC(=O)/C(=C\c2cccnc2)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B02 compound treatment 6520.0 -108000.0 -4.21 5880.0 -136000.0 -5.1 -6.5815 -0.9954 1491875 TimTec1_005656 COc1ccc(cc1)S(=O)(=O)NCCC2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B03 compound treatment 173440.0 58500.0 2.27 157720.0 15900.0 0.6 2.0278 0.8638 3085609 TimTec1_005657 Cc1nn(c(O)c1CCC#N)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B04 compound treatment 52920.0 -62000.0 -2.41 15480.0 -126000.0 -4.74 -5.0537 -0.9505 3211533 TimTec1_005658 FC(F)(F)C(NCC1(CC2CC3CC(C2)C1)C3)(NC(=O)c4ccccc4)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B05 compound treatment 173960.0 59000.0 2.29 169520.0 27700.0 1.04 2.3552 0.9362 3085612 TimTec1_005659 COc1cc(NC=C2C(=O)NC(=O)NC2=O)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B06 compound treatment 177720.0 62800.0 2.44 152520.0 10700.0 0.4 2.0072 0.8128 3085613 TimTec1_005660 Cc1cc(cc(C)c1O)C(O)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B07 compound treatment 63560.0 -51400.0 -1.99 8640.0 -133000.0 -5.0 -4.9433 -0.9187 3211534 TimTec1_005661 FC(F)(F)c1ccccc1C2C3=C(CCCC3=O)Nc4ccc5ncccc5c24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B08 compound treatment 144360.0 29400.0 1.14 114280.0 -27500.0 -1.03 0.0771 0.0501 1339353 TimTec1_005662 CCc1ccc(cc1)C(=O)c2c(c(c3cc(ccn23)C(C)(C)C)S(=O)(=O)CC)S(=O)(=O)CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B09 compound treatment 171280.0 56400.0 2.19 135200.0 -6600.0 -0.25 1.3709 0.623 1735427 TimTec1_005663 CC1(C)CC(=O)CC(C)(C)N1OC(=O)c2ccccn2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B10 compound treatment 144440.0 29500.0 1.15 107920.0 -33900.0 -1.27 -0.0895 -0.0523 1503527 TimTec1_005664 CCC(NC(=O)c1ccc(cc1)S(=O)(=O)N2CCOCC2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B11 compound treatment 120280.0 5350.0 0.21 97320.0 -44500.0 -1.67 -1.0336 -0.6144 1555325 TimTec1_005665 CCOc1ccccc1NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B12 compound treatment 165400.0 50500.0 1.96 203480.0 61700.0 2.31 3.0217 0.9965 3085617 TimTec1_005666 COc1ccc(/C=N/n2c(=O)c(nn3cnnc23)C(C)(C)C)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B13 compound treatment 150760.0 35800.0 1.39 147280.0 5480.0 0.21 1.1285 0.8029 1402991 TimTec1_005667 Cc1ccc(Oc2cc(C#N)c(C#N)cc2n3nnc4ccccc34)cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B14 compound treatment 61440.0 -53500.0 -2.08 16240.0 -126000.0 -4.71 -4.7997 -0.9321 3085619 TimTec1_005668 CC/N=C\1/S/C(=C/c2sccc2C)/C(=O)N1CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B15 compound treatment 11120.0 -104000.0 -4.03 7440.0 -134000.0 -5.04 -6.4139 -0.9938 1257857 TimTec1_005669 OC1=C(C(C#Cc2ccccc2)C3=C(O)CCCC3=O)C(=O)CCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B16 compound treatment 175000.0 60100.0 2.33 112200.0 -29600.0 -1.11 0.8626 0.3341 1631021 TimTec1_005670 COc1ccccc1N2CCN(CC2)S(=O)(=O)c3c(C)ccc4nsnc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B17 compound treatment 134080.0 19200.0 0.74 113440.0 -28400.0 -1.06 -0.2272 -0.175 1219783 TimTec1_005671 COc1ccc(cc1)N2C(=O)NC(=O)C(Cc3ccc(O)c(OC)c3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B18 compound treatment 175760.0 60800.0 2.36 146440.0 4640.0 0.17 1.7921 0.7572 3211535 TimTec1_005672 Cc1cc(NC(=O)NC(=O)c2ccc(F)cc2)n[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B19 compound treatment 183080.0 68200.0 2.64 137440.0 -4360.0 -0.16 1.7541 0.6621 1033315 TimTec1_005673 Cc1cc(C)n(n1)C(=S)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B20 compound treatment 158640.0 43700.0 1.7 112200.0 -29600.0 -1.11 0.4137 0.204 3085624 TimTec1_005674 CSc1snc(O)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B21 compound treatment 144680.0 29800.0 1.15 85000.0 -56800.0 -2.13 -0.6912 -0.2851 3211536 TimTec1_005675 CCc1ccc(cc1)C2=Nn3c(C)nnc3SC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B22 compound treatment 93720.0 -21200.0 -0.82 61920.0 -79900.0 -3.0 -2.7018 -0.869 3085626 TimTec1_005676 O=C(Nc1cccc(c1)c2nnc(o2)c3ccco3)C(c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B23 mock treatment 182800.0 67900.0 2.63 164960.0 23200.0 0.87 2.4768 0.8931 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 B24 mock treatment 174040.0 59100.0 2.29 184320.0 42500.0 1.6 2.7502 0.9843 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C01 compound treatment 34280.0 -80600.0 -3.13 16160.0 -126000.0 -4.72 -5.547 -0.9802 1675170 TimTec1_005677 C(Oc1cccc(c1)c2nnc3ccc4ccccc4n23)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C02 compound treatment 9200.0 -106000.0 -4.1 7120.0 -135000.0 -5.05 -6.475 -0.9946 1346658 TimTec1_005678 Fc1ccccc1C2Nc3ccc4ccccc4c3C5C=CCC52 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C03 compound treatment 135720.0 20800.0 0.81 133840.0 -7960.0 -0.3 0.3592 0.4175 3085628 TimTec1_005679 COC(C)n1cc(Br)c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C04 compound treatment 165000.0 50100.0 1.94 156360.0 14600.0 0.55 1.7602 0.8721 1681244 TimTec1_005680 Cc1cc(Oc2cc(C#N)c3ccccc3n2)ccc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C05 compound treatment 136040.0 21100.0 0.82 129160.0 -12600.0 -0.47 0.2438 0.2575 3085667 TimTec1_005681 Fc1ccc2C(=O)N(N3CCOCC3)C(=O)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C06 compound treatment 35480.0 -79400.0 -3.08 25640.0 -116000.0 -4.36 -5.2625 -0.9856 1270347 TimTec1_005682 Cn1c(=N)n(CC(=O)C2(CC3CC4CC(C3)C2)C4)c5ccccc15 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C07 compound treatment 114320.0 -606.0 -0.02 80280.0 -61500.0 -2.31 -1.6494 -0.7143 1454435 TimTec1_005683 CSc1nc2-c3ccccc3CC(C)(C)c2c(=O)n1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C08 compound treatment 106240.0 -8690.0 -0.34 93000.0 -48800.0 -1.83 -1.5335 -0.8234 1371600 TimTec1_005684 Cc1ccc(cc1)C(=O)Cn2c(=N)n(C)c3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C09 compound treatment 14800.0 -100000.0 -3.88 12000.0 -130000.0 -4.87 -6.1919 -0.9937 1605543 TimTec1_005685 CSC1=NC2(Cc3ccccc13)CCCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C10 compound treatment 119960.0 5030.0 0.2 144400.0 2600.0 0.1 0.207 0.9485 1564745 TimTec1_005686 CC(C)(O)C#Cc1ccc(cc1)C(=O)NCC(c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C11 compound treatment 135840.0 20900.0 0.81 181200.0 39400.0 1.48 1.6194 0.9601 3085653 TimTec1_005687 O=C(Nc1ccccc1)OCC23COC(N3C(OC2)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C12 compound treatment 116320.0 1390.0 0.05 153880.0 12100.0 0.45 0.3588 0.7859 1696532 TimTec1_005688 O=C1N(C(Nc2ccccc12)c3cccs3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C13 compound treatment 54080.0 -60800.0 -2.36 32520.0 -109000.0 -4.1 -4.5696 -0.9656 3211537 TimTec1_005689 Cc1ccc(/N=C/2\NC(=O)C(Cc3cccc(c3)C(F)(F)F)S2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C14 compound treatment 99800.0 -15100.0 -0.59 100880.0 -40900.0 -1.54 -1.501 -0.9129 1190215 TimTec1_005690 CC(C1Nc2ccccc2C(=O)N1c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C15 compound treatment 97120.0 -17800.0 -0.69 79680.0 -62100.0 -2.33 -2.1372 -0.8789 1378935 TimTec1_005691 CCOC(=O)c1c(NC(=O)CSc2ncccn2)sc3CCCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C16 compound treatment 134080.0 19200.0 0.74 128960.0 -12800.0 -0.48 0.1847 0.2085 1327450 TimTec1_005692 CCC(=O)Nc1nonc1c2nc3ccccc3n2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C17 compound treatment 117280.0 2350.0 0.09 99720.0 -42100.0 -1.58 -1.0522 -0.6651 3211622 TimTec1_005693 CCC(=O)NC(Nc1sc2CCCCc2c1C#N)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C18 compound treatment 134120.0 19200.0 0.74 139960.0 -1840.0 -0.07 0.4777 0.6387 1168333 TimTec1_005694 CC(C)CCN1NC2(CCCCC2)NC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C19 compound treatment 135280.0 20400.0 0.79 129960.0 -11800.0 -0.44 0.2441 0.2694 3211623 TimTec1_005695 CN1C2=C(C(NC1=O)c3ccccc3)C(=O)N(C2)c4ccc(C)c(C)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C20 compound treatment 144800.0 29900.0 1.16 104120.0 -37700.0 -1.41 -0.1804 -0.0987 1532646 TimTec1_005696 Cn1nccc1C(=O)NCCN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C21 compound treatment 181640.0 66700.0 2.59 144880.0 3080.0 0.12 1.912 0.7379 1534811 TimTec1_005697 COc1c(O)ccc2c(OC)c3ccoc3nc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C22 compound treatment 159240.0 44300.0 1.72 122840.0 -19000.0 -0.71 0.7125 0.3829 3085660 TimTec1_005698 Cn1c2ccccc2c3nnc(SCc4ccc(F)cc4Cl)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C23 mock treatment 175480.0 60600.0 2.35 145000.0 3200.0 0.12 1.7462 0.7423 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 C24 mock treatment 173320.0 58400.0 2.27 155560.0 13800.0 0.52 1.9672 0.8465 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D01 compound treatment 25880.0 -89000.0 -3.46 9880.0 -132000.0 -4.95 -5.9441 -0.9845 3211624 TimTec1_005699 CC1CN=C(S1)N(C(=O)Nc2ccccc2)c3ccc(OC(F)(F)F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D02 compound treatment 121160.0 6230.0 0.24 116640.0 -25200.0 -0.94 -0.4968 -0.5096 3085662 TimTec1_005700 C(Sc1ncn[nH]1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D03 compound treatment 74280.0 -40600.0 -1.58 51440.0 -90400.0 -3.39 -3.5133 -0.9393 3211625 TimTec1_005701 Cc1ccc(NC(=O)C2CC(=O)N(Cc3ccccc3)/C(=N/c4ccccc4)/S2)c(C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D04 compound treatment 6400.0 -109000.0 -4.21 5680.0 -136000.0 -5.11 -6.5901 -0.9954 3085663 TimTec1_005702 FC(F)(F)C(NCCc1c[nH]c2ccccc12)(NC(=O)c3ccccc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D05 compound treatment 7040.0 -108000.0 -4.19 6400.0 -135000.0 -5.08 -6.5534 -0.9954 3211626 TimTec1_005703 CCC1(C)OC(=Nc2ccccc21)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D06 compound treatment 5720.0 -109000.0 -4.24 4800.0 -137000.0 -5.14 -6.6321 -0.9954 1384761 TimTec1_005704 Oc1ccc(NC2=C(C(=O)c3ccccc3C2=O)n4nnc5ccccc45)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D07 compound treatment 65000.0 -49900.0 -1.94 45440.0 -96400.0 -3.62 -3.9271 -0.9572 1725838 TimTec1_005705 CSc1ccc(cc1)C2C3=C(CCCC3=O)Nc4ccc5ccccc5c24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D08 compound treatment 8920.0 -106000.0 -4.11 6280.0 -136000.0 -5.09 -6.505 -0.9944 1630880 TimTec1_005706 Cn1c(nn(C2CC(=O)C3OCC2O3)c1=S)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D09 compound treatment 29480.0 -85400.0 -3.32 22120.0 -120000.0 -4.49 -5.5205 -0.9888 1339859 TimTec1_005707 COc1cc2ccccc2cc1C(=O)NCCC3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D10 compound treatment 124080.0 9150.0 0.36 132400.0 -9400.0 -0.35 0.0016 0.0032 1488964 TimTec1_005708 CC(C)(C)c1ccc(cc1)C23OC(=O)C(C)(C)C3OC(=O)C2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D11 compound treatment 124880.0 9950.0 0.39 152920.0 11100.0 0.42 0.5681 0.9993 1458934 TimTec1_005709 C1CN(CCN1)C2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D12 compound treatment 14840.0 -100000.0 -3.88 29160.0 -113000.0 -4.23 -5.7354 -0.9991 3211627 TimTec1_005710 O=C/1NC(=S)N\C1=C\c2cc3ccccc3nc2N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D13 compound treatment 126600.0 11700.0 0.45 139440.0 -2360.0 -0.09 0.2576 0.5581 1617853 TimTec1_005711 Cc1cccc(C)c1NC(=O)C2(CCCC2)N(Cc3ccccc3)C(=O)c4ccc(cc4)n5cnnn5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D14 compound treatment 131200.0 16300.0 0.63 171040.0 29200.0 1.1 1.2224 0.9656 1422235 TimTec1_005712 Brc1ccc(CC2(CCc3ccncc3)C(=O)NC(=O)NC2=O)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D15 compound treatment 10880.0 -104000.0 -4.04 9960.0 -132000.0 -4.95 -6.3536 -0.9949 3211628 TimTec1_005713 CCN(CC)c1ccc(cc1)C2(NN(C(=C2C#N)N)c3ccccc3)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D16 compound treatment 62200.0 -52700.0 -2.05 34080.0 -108000.0 -4.04 -4.3054 -0.9502 3085673 TimTec1_005714 C/C(=N\c1ccccc1)/C2=C(O)C=C(CC2c3ccco3)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D17 compound treatment 49400.0 -65500.0 -2.54 16920.0 -125000.0 -4.69 -5.112 -0.9587 3211629 TimTec1_005715 Fc1ccc(CCN2C(=O)NC(=O)/C(=C\c3cccc4ccccc34)/C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D18 compound treatment 72760.0 -42200.0 -1.64 13440.0 -128000.0 -4.82 -4.5635 -0.8969 1524909 TimTec1_005716 COc1ccccc1c2nnc(o2)c3ccccc3O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D19 compound treatment 15480.0 -99400.0 -3.86 8600.0 -133000.0 -5.0 -6.2634 -0.9918 3211630 TimTec1_005717 COc1cccc(c1)c2cc(nc(SC3CC(=O)C4OCC3O4)n2)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D20 compound treatment 129520.0 14600.0 0.57 133880.0 -7920.0 -0.3 0.1901 0.2973 3085676 TimTec1_005718 FC(F)(F)c1cccc(c1)N2C(=O)CC(Cc3ccccc3)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D21 compound treatment 110200.0 -4730.0 -0.18 106560.0 -35200.0 -1.32 -1.065 -0.7975 3211631 TimTec1_005719 CC1(C)OC(=O)C(=Cc2cccn2c3ccc(cc3)S(=O)(=O)N)C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D22 compound treatment 103560.0 -11400.0 -0.44 96320.0 -45500.0 -1.71 -1.5189 -0.8615 3085679 TimTec1_005720 Cc1cccc2nc(=S)n(C(=O)c3ccc(F)cc3)n12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D23 mock treatment 137960.0 23000.0 0.89 132200.0 -9600.0 -0.36 0.3771 0.3913 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 D24 mock treatment 153840.0 38900.0 1.51 133080.0 -8720.0 -0.33 0.8362 0.5412 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E01 compound treatment 146080.0 31200.0 1.21 121440.0 -20400.0 -0.76 0.3143 0.2198 3211632 TimTec1_005721 Cc1cc(F)c(F)c(C(=O)n2ccnc2)c1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E02 compound treatment 121440.0 6510.0 0.25 107120.0 -34700.0 -1.3 -0.7417 -0.5594 1584802 TimTec1_005722 O=C(CSc1ccccc1)Nc2c(oc3ccccc23)C(=O)C4CC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E03 compound treatment 137040.0 22100.0 0.86 118200.0 -23600.0 -0.89 -0.0197 -0.0159 3211633 TimTec1_005723 COCc1cc(C)nc2sc(C(=O)OC)c(N)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E04 compound treatment 8920.0 -106000.0 -4.11 7240.0 -135000.0 -5.05 -6.4795 -0.9948 3211634 TimTec1_005724 CC(C)COC(=O)C1=C(C)Nc2cc(ccc2S1)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E05 compound treatment 11480.0 -103000.0 -4.01 9800.0 -132000.0 -4.95 -6.3413 -0.9945 3085682 TimTec1_005725 Fc1ccc(COc2ccccc2/C=C\3/C(=O)NC(=O)N(CC=C)C3=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E06 compound treatment 10160.0 -105000.0 -4.06 10760.0 -131000.0 -4.92 -6.3521 -0.9955 3211635 TimTec1_005726 CN(C)c1ccc(/C=C\2/Oc3c(ccc(O)c3O)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E07 compound treatment 92800.0 -22100.0 -0.86 73800.0 -68000.0 -2.55 -2.4118 -0.8956 3211636 TimTec1_005727 CCn/1c(cs\c1=N\c2cc(OC)c(Cl)cc2OC)c3ccc(F)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E08 compound treatment 49360.0 -65600.0 -2.54 35080.0 -107000.0 -4.01 -4.6312 -0.976 1668810 TimTec1_005728 N=C1OC23CCCCC3C(C#N)(C#N)C1(C#N)C(Cc4ccccc4)O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E09 compound treatment 131440.0 16500.0 0.64 123960.0 -17800.0 -0.67 -0.0204 -0.0221 1468867 TimTec1_005729 NS(=O)(=O)c1ccc(N=NN2CCCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E10 compound treatment 24200.0 -90700.0 -3.52 15600.0 -126000.0 -4.74 -5.8384 -0.9893 1221615 TimTec1_005730 CCc1ccc2cc(cn2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E11 compound treatment 99320.0 -15600.0 -0.61 102360.0 -39400.0 -1.48 -1.4749 -0.9222 3211637 TimTec1_005731 CC1SC(N(C1=O)c2ccccc2)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E12 compound treatment 125720.0 10800.0 0.42 138880.0 -2920.0 -0.11 0.2186 0.5049 1203111 TimTec1_005732 Cc1cc(C(=O)O)c(C#N)c(N)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E13 compound treatment 124000.0 9070.0 0.35 131200.0 -10600.0 -0.4 -0.0324 -0.061 3211638 TimTec1_005733 NC(=NS(=O)(=O)c1ccc(NC(=O)c2ccc(Cl)cc2)cc1)N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E14 compound treatment 131360.0 16400.0 0.64 129000.0 -12800.0 -0.48 0.1111 0.1392 3085709 TimTec1_005734 Cc1nc2ccccc2c(=O)n1c3ccc4OC(F)(F)Oc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E15 compound treatment 132800.0 17900.0 0.69 142040.0 237.0 0.01 0.4967 0.7161 3085711 TimTec1_005735 C/C(=C/C(=O)C1CC1)/C2CC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E16 compound treatment 55480.0 -59400.0 -2.31 59000.0 -82800.0 -3.11 -3.8284 -0.9892 1198283 TimTec1_005736 CC(C(=O)Nc1ccc2OCCOc2c1)n3nnc(n3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E17 compound treatment 126000.0 11100.0 0.43 126600.0 -15200.0 -0.57 -0.0996 -0.1395 1200453 TimTec1_005737 CC1=C(C(C2=C(CC(C)(C)CC2=O)N1)c3ccc4OCOc4c3)C(=O)Nc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E18 compound treatment 82680.0 -32200.0 -1.25 66520.0 -75300.0 -2.83 -2.8826 -0.9329 1488913 TimTec1_005738 CCCc1cc(O)nc(SCC(=O)N2c3ccccc3Sc4ccccc24)n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E19 compound treatment 130560.0 15600.0 0.61 124240.0 -17600.0 -0.66 -0.0372 -0.0415 1378082 TimTec1_005739 CCOC(=O)C1(CCN(CC1)C(=O)c2ccccc2O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E20 compound treatment 130760.0 15800.0 0.61 132200.0 -9600.0 -0.36 0.1796 0.2521 1283200 TimTec1_005740 CC(C)N1C2OC(OC2N(C(C)C)S1(=O)=O)C3OC4C(O3)N(C(C)C)S(=O)(=O)N4C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E21 compound treatment 107280.0 -7650.0 -0.3 101840.0 -40000.0 -1.5 -1.2703 -0.8309 1315806 TimTec1_005741 CC(=O)Oc1ccc(C)cc1n2nc3ccccc3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E22 compound treatment 127520.0 12600.0 0.49 118240.0 -23600.0 -0.88 -0.2798 -0.2769 3085715 TimTec1_005742 COc1ccccc1N/C=C/2\C(=O)NC(=O)N(C2=O)c3ccccc3OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E23 mock treatment 126080.0 11200.0 0.43 133920.0 -7880.0 -0.3 0.0968 0.1847 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 E24 mock treatment 124160.0 9230.0 0.36 133640.0 -8160.0 -0.31 0.0367 0.0779 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F01 compound treatment 150120.0 35200.0 1.37 123920.0 -17900.0 -0.67 0.491 0.3227 1415787 TimTec1_005743 O=C(Cn1nnc(n1)c2ccc3OCOc3c2)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F02 compound treatment 112640.0 -2290.0 -0.09 100480.0 -41300.0 -1.55 -1.1594 -0.7463 1291024 TimTec1_005744 Cc1[nH]c2ccccc2c1CCNC(=O)c3cc4cc(Br)ccc4oc3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F03 compound treatment 42400.0 -72500.0 -2.81 33600.0 -108000.0 -4.06 -4.8614 -0.9839 3085718 TimTec1_005745 FC(F)(F)c1nnc(S)n1/N=C/c2ccc(Cl)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F04 compound treatment 116080.0 1150.0 0.04 136920.0 -4880.0 -0.18 -0.0979 -0.5191 1647381 TimTec1_005746 CC1CCN(CC1)S(=O)(=O)c2ccc(cc2)C(=O)NCc3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F05 compound treatment 133120.0 18200.0 0.71 135520.0 -6280.0 -0.24 0.3324 0.4467 1416263 TimTec1_005747 Cc1c(NC(=O)C2CCCC2)c(=O)n(c3ccccc3)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F06 compound treatment 119560.0 4630.0 0.18 141080.0 -723.0 -0.03 0.108 0.5937 3211747 TimTec1_005748 Cc1cc(S)c2n(Cc3ccc(Cl)cc3Cl)nc[n+]2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F07 compound treatment 130280.0 15400.0 0.6 123960.0 -17800.0 -0.67 -0.0523 -0.0583 1581088 TimTec1_005749 Fc1cccc(Cl)c1C2N3CCCCN23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F08 compound treatment 101440.0 -13500.0 -0.52 110840.0 -31000.0 -1.16 -1.1917 -0.9351 1406168 TimTec1_005750 COC(=O)c1ccc(CSc2nnc3c4ccccc4n(C)c3n2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F09 compound treatment 109840.0 -5090.0 -0.2 105800.0 -36000.0 -1.35 -1.095 -0.8019 3211748 TimTec1_005751 Cc1cc(C)c(c(C)c1)n2nnnc2SCC(=O)Nc3nn(nc3C(=O)N)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F10 compound treatment 125720.0 10800.0 0.42 127600.0 -14200.0 -0.53 -0.0808 -0.1192 3087784 TimTec1_005752 CC1(NC(C2C1C(=O)N(C2=O)c3ccccc3)c4cc(Br)ccc4O)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F11 compound treatment 131120.0 16200.0 0.63 134560.0 -7240.0 -0.27 0.2521 0.3682 3211749 TimTec1_005753 N#CCC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F12 compound treatment 106120.0 -8810.0 -0.34 117560.0 -24200.0 -0.91 -0.885 -0.9106 1605647 TimTec1_005754 COc1ccc(cc1OC)C2C(Oc3ccc(Cl)cc3C)C(=O)N2c4ccc(C)c(C)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F13 compound treatment 123760.0 8830.0 0.34 136360.0 -5440.0 -0.2 0.0979 0.2454 3087785 TimTec1_005755 C[S+](C)c1c(O)n(c2ccccc2F)c(=O)[nH]c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F14 compound treatment 122360.0 7430.0 0.29 137360.0 -4440.0 -0.17 0.0861 0.2583 1201797 TimTec1_005756 Fc1cc(Cl)c(cc1F)C(=O)NC2C3CC4CC(C3)CC2C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F15 compound treatment 156280.0 41400.0 1.6 129520.0 -12300.0 -0.46 0.8086 0.4844 1326307 TimTec1_005757 CC(Sc1nc(N)cc(N)n1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F16 compound treatment 111200.0 -3730.0 -0.14 122080.0 -19700.0 -0.74 -0.6256 -0.8295 1664927 TimTec1_005758 C=CCn1c2ccccc2c3nnc(SCc4ccc5nonc5c4)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F17 compound treatment 138440.0 23500.0 0.91 130120.0 -11700.0 -0.44 0.3351 0.331 3087786 TimTec1_005759 CC(Nc1nc(F)cc(=O)[nH]1)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F18 compound treatment 58480.0 -56400.0 -2.19 114040.0 -27800.0 -1.04 -2.2854 -0.9423 3211750 TimTec1_005760 CCOC(=O)/C=C/1\NC(C)(C)Cc2cc(OC)c(O)cc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F19 compound treatment 48120.0 -66800.0 -2.59 50240.0 -91600.0 -3.44 -4.2629 -0.9903 3211751 TimTec1_005761 O=C(CSc1nnnn1c2ccccc2)NCCC3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F20 compound treatment 95880.0 -19000.0 -0.74 94480.0 -47300.0 -1.78 -1.7784 -0.9245 3087787 TimTec1_005762 CC1SC2(CCCCC2)N(C1=O)c3cc(C)cc(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F21 compound treatment 84920.0 -30000.0 -1.16 76360.0 -65400.0 -2.46 -2.56 -0.9418 3211752 TimTec1_005763 CC(=O)NC(NCCC1(CC2CC3CC(C2)C1)C3)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F22 compound treatment 63320.0 -51600.0 -2.0 52040.0 -89800.0 -3.37 -3.7981 -0.9691 1523330 TimTec1_005764 O=C(Oc1ccc(cc1)N(C(=O)c2ccccc2)S(=O)(=O)c3cccs3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F23 mock treatment 126120.0 11200.0 0.43 123080.0 -18700.0 -0.7 -0.1898 -0.2297 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 F24 mock treatment 136280.0 21400.0 0.83 125320.0 -16500.0 -0.62 0.1484 0.1436 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G01 compound treatment 151480.0 36600.0 1.42 161880.0 20100.0 0.75 1.5357 0.9562 3087788 TimTec1_005765 Fc1ccccc1c2nnc3ccc(cn23)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G02 compound treatment 123840.0 8910.0 0.35 116120.0 -25700.0 -0.96 -0.437 -0.4267 3211753 TimTec1_005766 CN1C(=O)N(C)C2(N=C3SCC(=O)N3NC12c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G03 compound treatment 116400.0 1470.0 0.06 118480.0 -23300.0 -0.88 -0.5785 -0.6595 1444799 TimTec1_005767 OC1=C(C(N(C1=O)c2cccnc2)c3ccccc3)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G04 compound treatment 121400.0 6470.0 0.25 112160.0 -29600.0 -1.11 -0.6091 -0.534 1457617 TimTec1_005768 O=C(N1N=CCC1c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G05 compound treatment 114640.0 -286.0 -0.01 116240.0 -25600.0 -0.96 -0.6862 -0.7152 1406350 TimTec1_005769 Clc1ccccc1C(=O)Nc2ccc3nc(SCC(=O)N4CCc5ccccc45)sc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G06 compound treatment 122240.0 7310.0 0.28 132440.0 -9360.0 -0.35 -0.0478 -0.1058 1302719 TimTec1_005770 COC(=O)c1ccccc1NCNc2ccccc2C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G07 compound treatment 116440.0 1510.0 0.06 125160.0 -16600.0 -0.62 -0.4001 -0.6378 1261268 TimTec1_005771 CCCC(=C1C(=O)NC(=O)NC1=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G08 compound treatment 56040.0 -58900.0 -2.28 66480.0 -75300.0 -2.83 -3.6146 -0.9944 1028239 TimTec1_005772 S=c1sscc1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G09 compound treatment 117680.0 2750.0 0.11 127880.0 -13900.0 -0.52 -0.2939 -0.5511 3211754 TimTec1_005773 CCOC(=O)Cc1nc(C)cs1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G10 compound treatment 126640.0 11700.0 0.45 130480.0 -11300.0 -0.42 0.0209 0.0336 1366551 TimTec1_005774 CCC1C(OC(=O)C(C)(C)C1=O)c2cccc(Br)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G11 compound treatment 125920.0 11000.0 0.43 127200.0 -14600.0 -0.55 -0.0859 -0.1237 3087789 TimTec1_005775 CC(=O)OC(C)(C)C#CCN1CCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G12 compound treatment 105680.0 -9250.0 -0.36 127080.0 -14700.0 -0.55 -0.6444 -0.9781 3211755 TimTec1_005776 O=C/1Nc2ccccc2\C1=C/3\NC(=S)N(C3=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G13 compound treatment 122280.0 7350.0 0.29 129600.0 -12200.0 -0.46 -0.1221 -0.2262 3087790 TimTec1_005777 CCOC1=NOC2C3CCC(C3)C21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G14 compound treatment 121320.0 6390.0 0.25 134360.0 -7440.0 -0.28 -0.0221 -0.0591 3211756 TimTec1_005778 COc1ccc(cc1)C2OCC(C)(CO2)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G15 compound treatment 120200.0 5270.0 0.2 132520.0 -9280.0 -0.35 -0.1017 -0.2516 3087791 TimTec1_005779 Nc1ccc(OC(F)(F)F)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G16 compound treatment 112920.0 -2010.0 -0.08 124960.0 -16800.0 -0.63 -0.502 -0.7882 1233416 TimTec1_005780 C(Sc1nnnn1c2ccc3OCOc3c2)C4CC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G17 compound treatment 120400.0 5470.0 0.21 130680.0 -11100.0 -0.42 -0.145 -0.3096 1922264 TimTec1_005781 CC1(C)COC(O)(CC1=O)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G18 compound treatment 115160.0 234.0 0.01 119760.0 -22000.0 -0.83 -0.5786 -0.6993 1589793 TimTec1_005782 CCc1ccc(cc1)C2Nc3ccccc3C(=O)N2c4ccc(cc4)N(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G19 compound treatment 118440.0 3510.0 0.14 132840.0 -8960.0 -0.34 -0.1414 -0.3897 3087792 TimTec1_005783 CSC1=NC2C(N1)N(C)C(=O)N2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G20 compound treatment 20240.0 -94700.0 -3.67 21280.0 -121000.0 -4.52 -5.7963 -0.9947 1362774 TimTec1_005784 N=C1OC23CCCCC3C(C#N)(C#N)C1(C#N)C(O2)c4cccnc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G21 compound treatment 121000.0 6070.0 0.24 123720.0 -18100.0 -0.68 -0.3132 -0.436 3087793 TimTec1_005785 O=C(Oc1ccc(cc1)c2cnc3ccccc3n2)/C=C/c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G22 compound treatment 103080.0 -11800.0 -0.46 96280.0 -45500.0 -1.71 -1.5331 -0.8665 1511555 TimTec1_005786 Clc1ccc2oc(=O)n(C(=O)NC3CCCCC3)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G23 mock treatment 116400.0 1470.0 0.06 122120.0 -19700.0 -0.74 -0.4819 -0.6504 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 G24 mock treatment 110960.0 -3970.0 -0.15 145000.0 3200.0 0.12 -0.024 -0.1227 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H01 compound treatment 106840.0 -8090.0 -0.31 146600.0 4800.0 0.18 -0.0945 -0.2613 1788039 TimTec1_005787 Fc1ccccc1c2nnn(CC(=O)N3CCCCC3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H02 compound treatment 112680.0 -2250.0 -0.09 92680.0 -49100.0 -1.84 -1.3653 -0.7397 1578958 TimTec1_005788 COc1ccc(Cl)cc1S(=O)(=O)N2CCN(CC2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H03 compound treatment 124800.0 9870.0 0.38 136840.0 -4960.0 -0.19 0.1392 0.3268 3087794 TimTec1_005789 COc1cc2CC(C)(C)N=C(NC(C)C(=O)O)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H04 compound treatment 121960.0 7030.0 0.27 116800.0 -25000.0 -0.94 -0.4706 -0.4815 3087795 TimTec1_005790 NCCN1C(=O)S/C(=C/c2cccs2)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H05 compound treatment 174480.0 59600.0 2.31 140000.0 -1800.0 -0.07 1.5861 0.6861 1701075 TimTec1_005791 CCn1c(=N)n(CC(=O)c2cccs2)c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H06 compound treatment 125760.0 10800.0 0.42 134560.0 -7240.0 -0.27 0.105 0.2098 1332043 TimTec1_005792 COC(=O)NC1CSCC1OC(=O)CCCN2C(=O)c3ccccc3C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H07 compound treatment 98480.0 -16400.0 -0.64 102480.0 -39300.0 -1.48 -1.4948 -0.9297 3087798 TimTec1_005793 COc1nsc(SC)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H08 compound treatment 97640.0 -17300.0 -0.67 104320.0 -37500.0 -1.41 -1.469 -0.9426 1015156 TimTec1_005794 COc1ccc(Cl)cc1NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H09 compound treatment 71400.0 -43500.0 -1.69 80200.0 -61600.0 -2.31 -2.829 -0.9881 1397048 TimTec1_005795 COc1cc2ccccc2cc1C(=O)NC(C)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H10 compound treatment 102800.0 -12100.0 -0.47 118960.0 -22800.0 -0.86 -0.9389 -0.9601 3087801 TimTec1_005796 CC1(C)CC(=O)C2=C(C1)N(C(=C(C#N)C2c3ccsc3)N)c4c(F)cccc4F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H11 compound treatment 126960.0 12000.0 0.47 129480.0 -12300.0 -0.46 0.0031 0.0048 1338227 TimTec1_005797 COc1ccc(NC(=O)c2cnn(c2NC(=O)c3ccccc3F)c4ccccc4)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H12 compound treatment 51760.0 -63200.0 -2.45 72240.0 -69600.0 -2.61 -3.5791 -0.9995 1493728 TimTec1_005798 C1Oc2ccc(cc2O1)c3cc4ccccn4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H13 compound treatment 112960.0 -1970.0 -0.08 116120.0 -25700.0 -0.96 -0.7355 -0.7607 1440128 TimTec1_005799 COc1cc(NC(=O)NC2(CC2)c3ccccc3)c(OC)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H14 compound treatment 128840.0 13900.0 0.54 128560.0 -13200.0 -0.5 0.0303 0.0413 1272978 TimTec1_005800 Cc1cc(NS(=O)(=O)c2ccccc2)cc(c1O)S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H15 compound treatment 104440.0 -10500.0 -0.41 129680.0 -12100.0 -0.45 -0.6094 -0.9984 3211757 TimTec1_005801 Cc1cc(Cl)nc(NN)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H16 compound treatment 104040.0 -10900.0 -0.42 124640.0 -17200.0 -0.64 -0.7541 -0.9791 1520603 TimTec1_005802 Cn1c2ccc(Br)cc2c3nnc(SCc4ccc5nonc5c4)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H17 compound treatment 125560.0 10600.0 0.41 131200.0 -10600.0 -0.4 0.0104 0.0181 1486800 TimTec1_005803 CN(C)CP(=O)(O)CCn1c2ccccc2c3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H18 compound treatment 113880.0 -1050.0 -0.04 126920.0 -14900.0 -0.56 -0.4237 -0.7565 1194716 TimTec1_005804 OC(=O)C1Sc2c(sc(=O)n2Cc3ccccc3)C4C1C(=O)Oc5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H19 compound treatment 119440.0 4510.0 0.18 125640.0 -16200.0 -0.61 -0.3051 -0.4832 1203354 TimTec1_005805 Nc1nnc(CCCn2c(=O)oc3ccccc23)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H20 compound treatment 100840.0 -14100.0 -0.55 110040.0 -31800.0 -1.19 -1.2294 -0.9375 3087859 TimTec1_005806 CC/N=C\1/S/C(=C/c2ccc(o2)c3ccc(F)cc3)/C(=O)N1CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H21 compound treatment 129000.0 14100.0 0.55 125960.0 -15800.0 -0.59 -0.0343 -0.0425 1544104 TimTec1_005807 CN(C)c1ccc(cc1)C2OC(=O)C(C)(C)C(=O)C2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H22 compound treatment 113000.0 -1930.0 -0.07 115520.0 -26300.0 -0.99 -0.7504 -0.7585 3211853 TimTec1_005808 CCCn1c2ccccc2c3nnc(SCC(=O)NCc4ccc5OCOc5c4)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H23 mock treatment 130480.0 15600.0 0.6 124840.0 -17000.0 -0.64 -0.0234 -0.0267 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 H24 mock treatment 96480.0 -18400.0 -0.72 126880.0 -14900.0 -0.56 -0.9021 -0.9926 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I01 compound treatment 100800.0 -14100.0 -0.55 106560.0 -35200.0 -1.32 -1.3229 -0.9239 1315061 TimTec1_005809 CCOC1(C)N(Nc2ccccc2C(=O)CC)c3ccccc3C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I02 compound treatment 97360.0 -17600.0 -0.68 135720.0 -6080.0 -0.23 -0.6434 -0.8951 1011005 TimTec1_005810 OC(=O)CSc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I03 compound treatment 112520.0 -2410.0 -0.09 121480.0 -20300.0 -0.76 -0.6053 -0.7878 3211854 TimTec1_005811 CC1(C)OC(=O)N(Nc2ccccc2)C1(C)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I04 compound treatment 50120.0 -64800.0 -2.51 50080.0 -91700.0 -3.44 -4.2122 -0.9881 3087863 TimTec1_005812 Cc1c(Cl)cccc1NN 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I05 compound treatment 105480.0 -9450.0 -0.37 117680.0 -24100.0 -0.91 -0.8993 -0.9208 1462704 TimTec1_005813 CC(C)(C)NC(=O)CSc1nc2ccc(cc2s1)N3C(=O)c4ccccc4C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I06 compound treatment 119600.0 4670.0 0.18 126760.0 -15000.0 -0.56 -0.271 -0.457 1663326 TimTec1_005814 Cc1cc(C)n2nc(nc2n1)S(=O)(=O)Nc3ccccc3C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I07 compound treatment 21600.0 -93300.0 -3.62 18680.0 -123000.0 -4.62 -5.828 -0.9927 3211855 TimTec1_005815 C1C/C(=C\c2nc3ccccc3[nH]2)/C(=C1)N4CCOCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I08 compound treatment 93960.0 -21000.0 -0.81 108160.0 -33600.0 -1.26 -1.4681 -0.9774 1375813 TimTec1_005816 CN(C)c1ccc(cc1)C2N(Cc3ccccc3)C(=O)C(=C2C(=O)c4ccc(Cl)cc4)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I09 compound treatment 10200.0 -105000.0 -4.06 11320.0 -130000.0 -4.9 -6.3361 -0.9957 3087867 TimTec1_005817 COC(=O)c1c(CSC(=N)N)nc2n(Cc3ccccc3)c4ccccc4n12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I10 compound treatment 113920.0 -1010.0 -0.04 122880.0 -18900.0 -0.71 -0.5298 -0.7448 3211856 TimTec1_005818 CC1=C(OC(=O)c2ccccc2)C(C)(C)C(OC1=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I11 compound treatment 124360.0 9430.0 0.37 129120.0 -12700.0 -0.48 -0.0778 -0.1295 3087868 TimTec1_005819 COC(=O)c1ccc(/N=C/2\SC(CC(=O)N2C)C(=O)O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I12 compound treatment 127560.0 12600.0 0.49 131400.0 -10400.0 -0.39 0.0706 0.1126 3211857 TimTec1_005820 COc1ccc(/C=N/c2nnc(c3ccccc3)c(n2)c4ccccc4)c(C(=O)O)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I13 compound treatment 37480.0 -77400.0 -3.0 15120.0 -127000.0 -4.75 -5.4868 -0.9755 3087871 TimTec1_005821 CC1CN(CN2C(=O)/C(=N\c3ccc4ccccc4c3)/c5ccccc25)CC(C)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I14 compound treatment 113320.0 -1610.0 -0.06 139920.0 -1880.0 -0.07 -0.094 -0.998 1190190 TimTec1_005822 CC(=O)OC1c2ccccc2NC(c3ccccc3)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I15 compound treatment 51920.0 -63000.0 -2.44 65520.0 -76300.0 -2.86 -3.7531 -0.9969 1442650 TimTec1_005823 COC(=O)C1=C(C)NC(=C(C#N)C1c2cccs2)SCC(=O)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I16 compound treatment 81080.0 -33800.0 -1.31 104840.0 -37000.0 -1.39 -1.9095 -0.9996 3087873 TimTec1_005824 SC1=C(C#N)C2(CCCCC2)C(C(=N)N1)c3nc(cs3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I17 compound treatment 110360.0 -4570.0 -0.18 134000.0 -7800.0 -0.29 -0.3323 -0.971 1201213 TimTec1_005825 OC(=O)c1ccc(N=NN2CCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I18 compound treatment 65840.0 -49100.0 -1.9 86480.0 -55300.0 -2.08 -2.8149 -0.9991 3211858 TimTec1_005826 CSc1ccc(cc1)S(=O)(=O)Nc2ccc(N3CCOCC3)c(Cl)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I19 compound treatment 41040.0 -73900.0 -2.87 35440.0 -106000.0 -3.99 -4.8499 -0.9868 1656330 TimTec1_005827 CC(C)(CN1CCN(CC1)C(c2ccccc2)c3ccccc3)NS(=O)(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I20 compound treatment 97200.0 -17700.0 -0.69 105880.0 -35900.0 -1.35 -1.4397 -0.9512 1594685 TimTec1_005828 CC1C(C#N)(C#N)C2(C#N)C(OC1(C)OC2=N)c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I21 compound treatment 108840.0 -6090.0 -0.24 120880.0 -20900.0 -0.79 -0.7222 -0.8808 3211859 TimTec1_005829 O=C/1N(CN2CCN(CC2)c3ccccc3)c4ccccc4\C1=N\c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I22 compound treatment 62360.0 -52600.0 -2.04 63440.0 -78400.0 -2.94 -3.5219 -0.984 1426903 TimTec1_005830 Nc1c(C#N)c(c(C#N)c2nc3ccccc3n12)c4cccc(O)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I23 mock treatment 120840.0 5910.0 0.23 142960.0 1160.0 0.04 0.193 0.8263 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 I24 mock treatment 100520.0 -14400.0 -0.56 135600.0 -6200.0 -0.23 -0.5598 -0.9246 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J01 compound treatment 115880.0 954.0 0.04 162240.0 20400.0 0.77 0.5686 0.7404 1380440 TimTec1_005831 CC(C)(CO)NC1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J02 compound treatment 12040.0 -103000.0 -3.99 8000.0 -134000.0 -5.02 -6.3737 -0.9935 1328534 TimTec1_005832 Clc1ccc(Cl)c(c1)S(=O)(=O)NCCC2(CC3CC4CC(C3)C2)C4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J03 compound treatment 108360.0 -6570.0 -0.25 128000.0 -13800.0 -0.52 -0.5464 -0.9466 3211860 TimTec1_005833 FC(F)(F)C1=CC(=NCCN1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J04 compound treatment 7440.0 -107000.0 -4.17 9120.0 -133000.0 -4.98 -6.4702 -0.9961 1159735 TimTec1_005834 CN(C)P1(=O)Nc2ccccc2S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J05 compound treatment 118520.0 3590.0 0.14 132640.0 -9160.0 -0.34 -0.1446 -0.3896 1421447 TimTec1_005835 CC(C)(O)C1(C)NCCc2ccccc21 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J06 compound treatment 21520.0 -93400.0 -3.62 26200.0 -116000.0 -4.34 -5.6306 -0.996 1178221 TimTec1_005836 CC1CC2(CC(C)(C)C1)NN(C(=S)N2)c3ccc(C)c(C)c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J07 compound treatment 118400.0 3470.0 0.13 125080.0 -16700.0 -0.63 -0.3485 -0.5429 1709992 TimTec1_005837 CC1(C)CC(CC(C)(C)N1)NCc2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J08 compound treatment 115840.0 914.0 0.04 137800.0 -4000.0 -0.15 -0.0811 -0.5257 1603180 TimTec1_005838 O=C(NC1CCCCC1)C2CC(=O)OC32CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J09 compound treatment 113440.0 -1490.0 -0.06 146680.0 4880.0 0.18 0.0887 0.462 1526847 TimTec1_005839 Cc1ccc2c3C(C4=C(CCCC4=O)Nc3ccc2n1)c5ccccc5C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J10 compound treatment 132640.0 17700.0 0.69 126360.0 -15400.0 -0.58 0.0762 0.0847 3211861 TimTec1_005840 CCc1nc2sc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N)c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J11 compound treatment 113400.0 -1530.0 -0.06 123360.0 -18400.0 -0.69 -0.5313 -0.7648 1564041 TimTec1_005841 CCN(C(=O)Cn1nnc(n1)c2ccc3OCOc3c2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J12 compound treatment 122600.0 7670.0 0.3 126760.0 -15000.0 -0.56 -0.1887 -0.2956 3087925 TimTec1_005842 FC(F)(F)c1nnc2SCC(=Nn12)c3ccc(Cl)cc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J13 compound treatment 122120.0 7190.0 0.28 135280.0 -6520.0 -0.24 0.0243 0.0654 3211862 TimTec1_005843 CCN1C(=O)C2NN=C(C2C1=O)C(=O)c3nc(Cl)ccc3Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J14 compound treatment 95440.0 -19500.0 -0.76 107720.0 -34100.0 -1.28 -1.4391 -0.9685 1209557 TimTec1_005844 COc1ccc(cc1)C(=O)Nc2cc(C)c(O)c(c2C)S(=O)(=O)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J15 compound treatment 7200.0 -108000.0 -4.18 9920.0 -132000.0 -4.95 -6.4556 -0.9965 3211863 TimTec1_005845 Sc1nc(SCCOc2ccccc2)nc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J16 compound treatment 114960.0 34.1 0.0 126320.0 -15500.0 -0.58 -0.41 -0.7055 3087928 TimTec1_005846 CC(C)(C)C(=O)/C=C/1\NCCN\C1=C/C(=O)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J17 compound treatment 118840.0 3910.0 0.15 121520.0 -20300.0 -0.76 -0.4309 -0.5551 1272266 TimTec1_005847 OC(=O)C(Cc1ccco1)P(=O)(O)CN2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J18 compound treatment 34600.0 -80300.0 -3.12 42000.0 -99800.0 -3.75 -4.8525 -0.9958 1688384 TimTec1_005848 O=C(Nc1ccccc1)c2cccc(c2)S(=O)(=O)NCC3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J19 compound treatment 113080.0 -1850.0 -0.07 118560.0 -23200.0 -0.87 -0.6675 -0.7626 1696945 TimTec1_005849 COc1cccc(c1)C(=O)Nc2cccc(C)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J20 compound treatment 12200.0 -103000.0 -3.99 35520.0 -106000.0 -3.99 -5.639 -1.0 3087931 TimTec1_005850 Cc1cccn2cc(cc12)c3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J21 compound treatment 123160.0 8230.0 0.32 139320.0 -2480.0 -0.09 0.16 0.4809 1142933 TimTec1_005851 Cc1ccc(cc1)C(=O)C2OC(=O)C(C)(C)C(=O)C2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J22 compound treatment 69200.0 -45700.0 -1.77 77920.0 -63900.0 -2.4 -2.9499 -0.989 3211864 TimTec1_005852 COc1cccc2cc(C(=O)NCCc3c(C)[nH]c4ccc(OC(F)(F)F)cc34)c(=O)oc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J23 mock treatment 117760.0 2830.0 0.11 130600.0 -11200.0 -0.42 -0.2195 -0.5052 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 J24 mock treatment 105960.0 -8970.0 -0.35 148440.0 6640.0 0.25 -0.0698 -0.1632 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K01 compound treatment 4960.0 -110000.0 -4.27 9280.0 -133000.0 -4.97 -6.534 -0.9971 1683560 TimTec1_005853 CCn1c(nc2ccccc12)C(O)c3cc(c(O)c(c3)C(C)(C)C)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K02 compound treatment 57080.0 -57800.0 -2.24 92600.0 -49200.0 -1.85 -2.8928 -0.9953 3088026 TimTec1_005854 O=C1CSC2=NCN(CN12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K03 compound treatment 65360.0 -49600.0 -1.92 79480.0 -62300.0 -2.34 -3.0139 -0.9953 3087964 TimTec1_005855 CCOC(=O)C1=C(C)NC(=NC1c2ccc(OC(=O)C)c(OC)c2)SC(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K04 compound treatment 122040.0 7110.0 0.28 122320.0 -19500.0 -0.73 -0.3219 -0.4118 3087966 TimTec1_005856 CC(=O)NCCOc1cccc2cccnc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K05 compound treatment 75680.0 -39200.0 -1.52 91920.0 -49900.0 -1.87 -2.4006 -0.9947 1264565 TimTec1_005857 Cn1c(SCc2ccc(F)c3ccccc23)nc4ccccc4c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K06 compound treatment 95680.0 -19200.0 -0.75 107040.0 -34800.0 -1.3 -1.4506 -0.9649 3211865 TimTec1_005858 Clc1ccc(/N=C/2\C(=O)N(CN3CCc4ccccc4C3)c5ccccc25)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K07 compound treatment 113760.0 -1170.0 -0.05 127040.0 -14800.0 -0.55 -0.4238 -0.7623 1638757 TimTec1_005859 CCN(CC)P1(=O)COc2ccccc2OC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K08 compound treatment 59200.0 -55700.0 -2.16 85960.0 -55800.0 -2.1 -3.0109 -0.9999 3211945 TimTec1_005860 CCC1CCC2(CC1)SCC(=O)N2c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K09 compound treatment 110800.0 -4130.0 -0.16 135320.0 -6480.0 -0.24 -0.2852 -0.9794 1385466 TimTec1_005861 COc1ccc(cc1)N(C)C(=O)C2COc3ccccc3O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K10 compound treatment 76440.0 -38500.0 -1.49 89360.0 -52400.0 -1.97 -2.4477 -0.9907 1301245 TimTec1_005862 Cc1ccc(NS(=O)(=O)c2c(C)ccc3nsnc23)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K11 compound treatment 116560.0 1630.0 0.06 124440.0 -17400.0 -0.65 -0.416 -0.6353 3087971 TimTec1_005863 CN(C)/C=N\c1ccc2nonc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K12 compound treatment 72200.0 -42700.0 -1.66 75720.0 -66100.0 -2.48 -2.926 -0.9808 1432844 TimTec1_005864 CCOC(=O)c1c(CN2CCCC2)n(C)c3cc(Br)c(OC)cc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K13 compound treatment 115160.0 234.0 0.01 131160.0 -10600.0 -0.4 -0.276 -0.6909 3211946 TimTec1_005865 CSC1=NC2(CC(Oc3cc(O)ccc32)c4ccccc4)CC(C)(C)N1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K14 compound treatment 103840.0 -11100.0 -0.43 123520.0 -18300.0 -0.69 -0.7894 -0.9747 3087973 TimTec1_005866 CC(=O)N1C(=O)/C(=C\c2cccnc2)/NC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K15 compound treatment 7360.0 -108000.0 -4.17 8400.0 -133000.0 -5.01 -6.4915 -0.9959 1685221 TimTec1_005867 CCOC(=O)c1c(NC(=O)CSc2nccn2C)sc3CC(C)CCc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K16 compound treatment 6800.0 -108000.0 -4.2 9200.0 -133000.0 -4.98 -6.4857 -0.9964 3087975 TimTec1_005868 Oc1ccccc1c2cc(nn2Cc3ccc(Cl)cc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K17 compound treatment 89480.0 -25400.0 -0.99 106080.0 -35700.0 -1.34 -1.6462 -0.9887 1551420 TimTec1_005869 COC(=O)c1ccc(N=NN2CCCCCC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K18 compound treatment 88240.0 -26700.0 -1.04 123920.0 -17900.0 -0.67 -1.2067 -0.978 1545682 TimTec1_005870 COc1ccc(cc1)C2CC(=O)Oc3ccc(cc23)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K19 compound treatment 59920.0 -55000.0 -2.13 98280.0 -43500.0 -1.63 -2.6642 -0.9913 1253632 TimTec1_005871 O=C(N(Cc1ccccc1)c2ccccn2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K20 compound treatment 97360.0 -17600.0 -0.68 118960.0 -22800.0 -0.86 -1.0882 -0.9935 3211947 TimTec1_005872 COc1nc(OC)nc(n1)n2cnc(NC(=O)Nc3cccc(Cl)c3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K21 compound treatment 19880.0 -95000.0 -3.69 48920.0 -92900.0 -3.49 -5.0727 -0.9996 1118061 TimTec1_005873 Sc1nc2-c3ccccc3CC(C4CCCCC4)c2c(=O)[nH]1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K22 compound treatment 17480.0 -97400.0 -3.78 26240.0 -116000.0 -4.34 -5.7404 -0.9977 3211948 TimTec1_005874 CCC(C#N)C1(CC2CC3CC(C2)C1)C3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K23 mock treatment 118400.0 3470.0 0.13 121320.0 -20500.0 -0.77 -0.4483 -0.5744 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 K24 mock treatment 92440.0 -22500.0 -0.87 167560.0 25800.0 0.97 0.0667 0.0512 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L01 compound treatment 73200.0 -41700.0 -1.62 142000.0 197.0 0.01 -1.1395 -0.7039 3087980 TimTec1_005875 COC(=O)c1ccc(cc1)C2OCC(C)(C)CO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L02 compound treatment 67040.0 -47900.0 -1.86 97720.0 -44100.0 -1.65 -2.4837 -0.9983 1135137 TimTec1_005876 CCOc1ccc(CCNS(=O)(=O)c2c(C)cc(C)cc2C)cc1OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L03 compound treatment 57360.0 -57600.0 -2.23 94000.0 -47800.0 -1.79 -2.848 -0.9941 3211949 TimTec1_005877 COc1ccc(CN/2C(=O)CC(S\C2=N/c3ccccc3)C(=O)N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L04 compound treatment 8360.0 -107000.0 -4.13 15240.0 -127000.0 -4.75 -6.2826 -0.9976 1515423 TimTec1_005878 CCOc1nc(Cl)nc(n1)N2CCCCC2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L05 compound treatment 107200.0 -7730.0 -0.3 118120.0 -23700.0 -0.89 -0.8405 -0.896 3088028 TimTec1_005879 COc1ccc(cc1)C(=O)NC(N2CCCCC2c3cccnc3)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L06 compound treatment 117040.0 2110.0 0.08 129920.0 -11900.0 -0.45 -0.2573 -0.5675 1732675 TimTec1_005880 CCOc1ccc(CC(=O)Nc2ccccc2)cc1OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L07 compound treatment 92080.0 -22800.0 -0.89 117760.0 -24000.0 -0.9 -1.2649 -1.0 1230635 TimTec1_005881 Cc1ccc2c3C(C4=C(CCCC4=O)Nc3ccc2n1)c5ccc(O)cc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L08 compound treatment 111480.0 -3450.0 -0.13 129840.0 -12000.0 -0.45 -0.412 -0.8795 1233176 TimTec1_005882 CCNC(=O)C1CC(=O)OC21CCCCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L09 compound treatment 111800.0 -3130.0 -0.12 129480.0 -12300.0 -0.46 -0.4128 -0.8633 1157682 TimTec1_005883 COCc1cc(C)nc(SCC(=O)N2CCCCC2)c1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L10 compound treatment 113840.0 -1090.0 -0.04 132640.0 -9160.0 -0.34 -0.273 -0.7879 3088032 TimTec1_005884 CC(=O)ON1C(C)(C)C=C(C(=O)N)C1(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L11 compound treatment 97120.0 -17800.0 -0.69 125840.0 -16000.0 -0.6 -0.9122 -0.9975 3211950 TimTec1_005885 COc1ccccc1n2c(S)nnc2Cc3ccc(Cl)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L12 compound treatment 117600.0 2670.0 0.1 121960.0 -19800.0 -0.74 -0.4532 -0.6028 1274328 TimTec1_005886 COc1ccccc1C2C3=C(CCCC3=O)Nc4ccc5ncccc5c24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L13 compound treatment 96240.0 -18700.0 -0.73 97280.0 -44500.0 -1.67 -1.6942 -0.9301 3211951 TimTec1_005887 COC(=O)C1=CN(CC2(CC3CC4CC(C3)C2)C4)C=C(C1c5ccc(F)cc5)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L14 compound treatment 90560.0 -24400.0 -0.95 105760.0 -36000.0 -1.35 -1.625 -0.9847 1513069 TimTec1_005888 CC(C)c1c(NC(=O)c2ccc(Cl)cc2)cc(C)c(O)c1S(=O)(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L15 compound treatment 103360.0 -11600.0 -0.45 125480.0 -16300.0 -0.61 -0.7505 -0.9883 1273520 TimTec1_005889 CCn1c(SCCn2c(=S)n(C)c3ccccc23)nc4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L16 compound treatment 88120.0 -26800.0 -1.04 110840.0 -31000.0 -1.16 -1.5572 -0.9985 1715744 TimTec1_005890 C(N1CCCC1)c2cc3ccccc3c4COCc42 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L17 compound treatment 12080.0 -103000.0 -3.99 20640.0 -121000.0 -4.55 -6.0372 -0.9979 1402014 TimTec1_005891 Cc1nc2cccc(C(=O)Oc3ccc(cc3)C(C)(C)C)c2o1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L18 compound treatment 6120.0 -109000.0 -4.22 15160.0 -127000.0 -4.75 -6.3462 -0.9983 1594146 TimTec1_005892 O=C(Nc1ccccc1)c2cccc(c2)S(=O)(=O)NCCC3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L19 compound treatment 108280.0 -6650.0 -0.26 135280.0 -6520.0 -0.24 -0.3554 -0.9997 3088038 TimTec1_005893 CCc1nnc(NC(=O)CSc2nnc(c3cccs3)n2CC=C)s1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L20 compound treatment 15200.0 -99700.0 -3.87 18800.0 -123000.0 -4.62 -6.0004 -0.9961 3211952 TimTec1_005894 CCN(CC)c1ccc(C=C2C(=O)OC(OC2=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L21 compound treatment 79840.0 -35100.0 -1.36 119000.0 -22800.0 -0.86 -1.5678 -0.975 3088039 TimTec1_005895 OC(=O)/C(=C/C(=O)c1ccccc1)/Nc2ccc(OC(F)(F)F)cc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L22 compound treatment 108080.0 -6850.0 -0.27 118200.0 -23600.0 -0.89 -0.8142 -0.8804 1788194 TimTec1_005896 CCOC(=O)c1c(C)c(NC(=O)C)c(C)n1C(=O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L23 mock treatment 97160.0 -17800.0 -0.69 123960.0 -17800.0 -0.67 -0.9609 -0.9999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 L24 mock treatment 96880.0 -18000.0 -0.7 154920.0 13100.0 0.49 -0.147 -0.1717 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M01 compound treatment 60080.0 -54800.0 -2.13 129480.0 -12300.0 -0.46 -1.8318 -0.8411 1430182 TimTec1_005897 Cc1cc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(C)cc3)no1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M02 compound treatment 93600.0 -21300.0 -0.83 157640.0 15800.0 0.59 -0.1648 -0.1617 1516860 TimTec1_005898 CCN1C2OC3OC4C(OC3OC2N(CC)S1(=O)=O)N(CC)S(=O)(=O)N4CC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M03 compound treatment 100200.0 -14700.0 -0.57 123160.0 -18600.0 -0.7 -0.8988 -0.9949 1315988 TimTec1_005899 Clc1ccccc1NCn2nc(c3ccccc3)n(CC=C)c2=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M04 compound treatment 100520.0 -14400.0 -0.56 113360.0 -28400.0 -1.07 -1.1501 -0.9544 3088042 TimTec1_005900 CCC(=O)NC(Nc1sc(C)c(CC)c1C#N)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M05 compound treatment 45360.0 -69600.0 -2.7 63880.0 -77900.0 -2.92 -3.9766 -0.9992 3211953 TimTec1_005901 CC(C)C1C(=C(N)Oc2n[nH]c(C)c12)C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M06 compound treatment 80040.0 -34900.0 -1.35 127480.0 -14300.0 -0.54 -1.3372 -0.9182 1171314 TimTec1_005902 COc1ccc(OC)c(CNc2ccc3n(C)c(C)nc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M07 compound treatment 50000.0 -64900.0 -2.52 124320.0 -17500.0 -0.66 -2.2453 -0.8625 3088045 TimTec1_005903 CCOC(=O)C1=C(C)NC(=NC1c2ccccc2)SCC(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M08 compound treatment 6440.0 -108000.0 -4.21 10120.0 -132000.0 -4.94 -6.4711 -0.9968 1705094 TimTec1_005904 OC(=O)Cc1c(Sc2ccccc2)c3ccccc3n1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M09 compound treatment 10360.0 -105000.0 -4.06 19880.0 -122000.0 -4.58 -6.1046 -0.9982 3211954 TimTec1_005905 CN(C)c1ccc(/C=C/2\C(=O)N(N=C2C(=O)Nc3ccccc3)c4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M10 compound treatment 18080.0 -96800.0 -3.76 18600.0 -123000.0 -4.62 -5.9267 -0.9947 1621165 TimTec1_005906 O1c2ccccc2N=C(c3ccccc3)c4ccccc14 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M11 compound treatment 95640.0 -19300.0 -0.75 116840.0 -25000.0 -0.94 -1.1916 -0.9938 1640716 TimTec1_005907 CCN(CC)C(=O)c1cn(nc1C2(CC3CC4CC(C3)C2)C4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M12 compound treatment 96560.0 -18400.0 -0.71 105640.0 -36200.0 -1.36 -1.4636 -0.9548 3211955 TimTec1_005908 OC(=O)C1CC(=O)N(CCc2ccccc2)/C(=N/CCc3ccccc3)/S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M13 compound treatment 73680.0 -41200.0 -1.6 85840.0 -56000.0 -2.1 -2.6168 -0.991 3088114 TimTec1_005909 CCCN1C(=O)/C(=C/C=C\2/Sc3ccccc3N2CCO)/SC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M14 compound treatment 79360.0 -35600.0 -1.38 101320.0 -40500.0 -1.52 -2.0501 -0.9988 1416853 TimTec1_005910 CCCCC(=O)Nc1ccc(cc1)c2csc(n2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M15 compound treatment 9120.0 -106000.0 -4.11 12320.0 -129000.0 -4.86 -6.3392 -0.9965 3088116 TimTec1_005911 FC(F)(F)c1cccc(/N=C/2\C(=O)N(CN3CCc4ccccc4C3)c5ccccc25)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M16 compound treatment 113480.0 -1450.0 -0.06 114400.0 -27400.0 -1.03 -0.7669 -0.7446 1117685 TimTec1_005912 CN(C)c1ccc(cc1)C2OC(COc3ccccc3)CN(O2)C(=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M17 compound treatment 92600.0 -22300.0 -0.87 121960.0 -19800.0 -0.74 -1.1391 -0.9972 1411622 TimTec1_005913 O=C(N(c1ccccc1)c2ccccc2)c3ccccc3C(=O)N4CCCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M18 compound treatment 15040.0 -99900.0 -3.88 55880.0 -85900.0 -3.22 -5.0208 -0.9958 1119974 TimTec1_005914 COc1ccc(cc1)c2nc(SCc3ccccc3C#N)[nH]c(=O)c2C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M19 compound treatment 66240.0 -48700.0 -1.89 105280.0 -36500.0 -1.37 -2.305 -0.9876 1518985 TimTec1_005915 CC(C1C(=C(N)Oc2c1c(=O)oc3ccccc23)C#N)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M20 compound treatment 92760.0 -22200.0 -0.86 107840.0 -34000.0 -1.27 -1.5095 -0.9817 3088119 TimTec1_005916 FC(F)(F)c1ccc(cc1)C(=O)Nc2cccc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M21 compound treatment 104440.0 -10500.0 -0.41 143840.0 2040.0 0.08 -0.2336 -0.5643 1232476 TimTec1_005917 CC1CN(C(=O)C)c2ccccc2NC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M22 compound treatment 90560.0 -24400.0 -0.95 125280.0 -16500.0 -0.62 -1.107 -0.9791 1452888 TimTec1_005918 O=C1N(C(=O)c2cccc3cccc1c23)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M23 mock treatment 117320.0 2390.0 0.09 162600.0 20800.0 0.78 0.6176 0.7857 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 M24 mock treatment 102360.0 -12600.0 -0.49 154280.0 12500.0 0.47 -0.0136 -0.0201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N01 compound treatment 4160.0 -111000.0 -4.3 17480.0 -124000.0 -4.67 -6.3384 -0.9992 1241281 TimTec1_005919 COc1cc(NC(=O)c2cc3ccccc3cc2OCC(=O)NC(C)(C)C)c(OC)cc1Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N02 compound treatment 88800.0 -26100.0 -1.01 171280.0 29500.0 1.11 0.0655 0.0437 3088122 TimTec1_005920 CCn/1cccc\c1=N/P2(=S)OCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N03 compound treatment 32600.0 -82300.0 -3.19 56960.0 -84800.0 -3.18 -4.5103 -1.0 1595949 TimTec1_005921 OC1=C(C(N(CCc2ccccc2)C1=O)c3ccccc3)C(=O)c4cccs4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N04 compound treatment 88600.0 -26300.0 -1.02 131040.0 -10800.0 -0.4 -1.0079 -0.9176 1572095 TimTec1_005922 COCc1cc(C)nc2[nH]nc(N)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N05 compound treatment 80040.0 -34900.0 -1.35 123120.0 -18700.0 -0.7 -1.4529 -0.9531 3212011 TimTec1_005923 O=C(NCCOc1ccccc1)/C=C/c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N06 compound treatment 93600.0 -21300.0 -0.83 116880.0 -24900.0 -0.94 -1.2465 -0.9981 3212012 TimTec1_005924 CCOC(=O)c1cn(nc1N)C2CC(=O)C3OCC2O3.CCOC(=O)c1cn(nc1N)C2CC(O)(O)C3OCC2O3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N07 compound treatment 73840.0 -41100.0 -1.59 114960.0 -26800.0 -1.01 -1.8396 -0.9755 3088126 TimTec1_005925 NC[C@@H]1CCCN2CCCC[C@H]12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N08 compound treatment 100680.0 -14200.0 -0.55 116280.0 -25500.0 -0.96 -1.0682 -0.9659 1354761 TimTec1_005926 CCC(C)NCc1ccc(o1)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N09 compound treatment 86880.0 -28000.0 -1.09 114640.0 -27200.0 -1.02 -1.4903 -0.9995 1518220 TimTec1_005927 CSC1=NC(=C(C(=O)Nc2ccccc2)C3(CCCCC3)C1C(=O)N)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N10 compound treatment 5400.0 -110000.0 -4.25 8840.0 -133000.0 -4.99 -6.5336 -0.9968 3212013 TimTec1_005928 OC1(O)CC(C2COC1O2)n3nc(c4ccco4)n(CC=C)c3=S.C=CCn1c(nn(C2CC(=O)C3OCC2O3)c1=S)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N11 compound treatment 5640.0 -109000.0 -4.24 64520.0 -77300.0 -2.9 -5.0494 -0.9829 3088130 TimTec1_005929 Cc1cc2CC(C)(C)N/C(=C/C(=O)N)/c2cc1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N12 compound treatment 60880.0 -54000.0 -2.1 69040.0 -72800.0 -2.73 -3.4138 -0.9915 1138138 TimTec1_005930 CCOC(=O)c1[nH]c(C)c(CNc2ccccc2)c1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N13 compound treatment 106120.0 -8810.0 -0.34 111240.0 -30600.0 -1.15 -1.0527 -0.8795 1675612 TimTec1_005931 COc1nonc1n2nnc(C(=O)c3ccccc3)c2C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N14 compound treatment 139200.0 24300.0 0.94 117200.0 -24600.0 -0.92 0.0131 0.0099 1140939 TimTec1_005932 CCCc1c(C)[nH]c2nc3ccccc3n2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N15 compound treatment 91760.0 -23200.0 -0.9 115880.0 -25900.0 -0.97 -1.3235 -0.9992 3088132 TimTec1_005933 Clc1ccccc1c2nnc3cccc(Cl)n23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N16 compound treatment 14960.0 -100000.0 -3.88 46320.0 -95500.0 -3.58 -5.2767 -0.9992 1219341 TimTec1_005934 CCN(C(=O)c1c(C)c(Cl)c(C)nc1Oc2ccc(F)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N17 compound treatment 78400.0 -36500.0 -1.42 119920.0 -21900.0 -0.82 -1.5829 -0.9663 1518508 TimTec1_005935 CC(=O)N(CC1(CC2CC3CC(C2)C1)C3)C4CC(=O)N(C4=O)c5cccc(Cl)c5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N18 compound treatment 80520.0 -34400.0 -1.33 118640.0 -23200.0 -0.87 -1.5587 -0.9784 3088204 TimTec1_005936 Cn1nc(cc1Cl)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N19 compound treatment 83160.0 -31800.0 -1.23 119160.0 -22600.0 -0.85 -1.4724 -0.9835 3088206 TimTec1_005937 Cc1ccc(N/C(=C/C(=O)c2ccccc2)/C(=O)O)cc1Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N20 compound treatment 48960.0 -66000.0 -2.56 87920.0 -53900.0 -2.02 -3.2398 -0.9932 3088207 TimTec1_005938 CC(C)(C)C1(C)OC(=O)C(=Cc2ccc(Br)o2)C(=O)O1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N21 compound treatment 90040.0 -24900.0 -0.97 119600.0 -22200.0 -0.83 -1.272 -0.9973 3212014 TimTec1_005939 COCCN1C=C(C(C(=C1)C(=O)OC)c2cccs2)C(=O)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N22 compound treatment 94240.0 -20700.0 -0.8 121560.0 -20200.0 -0.76 -1.1048 -0.9996 3212015 TimTec1_005940 CN/1CCC\C1=C\C=C\2/SC(=S)NC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N23 mock treatment 91600.0 -23300.0 -0.91 130360.0 -11400.0 -0.43 -0.9436 -0.942 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 N24 mock treatment 100040.0 -14900.0 -0.58 160200.0 18400.0 0.69 0.0798 0.0887 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O01 compound treatment 80640.0 -34300.0 -1.33 127240.0 -14600.0 -0.55 -1.3271 -0.9228 1199249 TimTec1_005941 CCCn1c2ccccc2c3nnc(SCC(=O)NC(C)c4ccccc4)nc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O02 compound treatment 106160.0 -8770.0 -0.34 163800.0 22000.0 0.83 0.3433 0.3845 1786664 TimTec1_005942 CC(C)c1cc(=O)n2nc(N)[nH]c2n1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O03 compound treatment 84200.0 -30700.0 -1.19 95200.0 -46600.0 -1.75 -2.0798 -0.9825 3212016 TimTec1_005943 Fc1ccccc1COc2ccccc2/C=C\3/SC(=N)NC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O04 compound treatment 40840.0 -74100.0 -2.87 95240.0 -46600.0 -1.75 -3.2683 -0.9715 1724360 TimTec1_005944 c1c(nc2nc(c3ccccc3)c(nn12)c4ccccc4)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O05 compound treatment 59440.0 -55500.0 -2.15 92720.0 -49100.0 -1.84 -2.8249 -0.997 3088212 TimTec1_005945 O=C(CSC1=NC(CC(=O)N1)c2ccccc2)Nc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O06 compound treatment 71240.0 -43700.0 -1.7 135960.0 -5840.0 -0.22 -1.3536 -0.792 1025381 TimTec1_005946 COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O07 compound treatment 4400.0 -111000.0 -4.29 8520.0 -133000.0 -5.0 -6.5696 -0.9971 1512733 TimTec1_005947 COc1ccc(cc1)C2=C(C)C(c3cccs3)c4ccccc4O2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O08 compound treatment 60200.0 -54700.0 -2.12 125440.0 -16400.0 -0.61 -1.9357 -0.8757 3088214 TimTec1_005948 COC(=O)c1ccc(cc1)C2OCCCO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O09 compound treatment 13240.0 -102000.0 -3.95 23880.0 -118000.0 -4.43 -5.9194 -0.9984 3212017 TimTec1_005949 CCN(CC)N=Nc1n[nH]c2nc(C)cc(C)c12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O10 compound treatment 79440.0 -35500.0 -1.38 110200.0 -31600.0 -1.19 -1.8123 -0.9972 1112286 TimTec1_005950 CC(=O)Nc1ccc(Cl)cc1C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O11 compound treatment 23440.0 -91500.0 -3.55 58240.0 -83600.0 -3.14 -4.7277 -0.9981 3212018 TimTec1_005951 C1C(=CC(=NN=C1c2ccccc2)c3ccccc3)c4c[nH]c5ccccc45 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O12 compound treatment 82800.0 -32100.0 -1.25 78920.0 -62900.0 -2.36 -2.5502 -0.9555 3212019 TimTec1_005952 COc1cc(OC)c(/C=C/2\C(=O)NC(=O)N(C3CCCCC3)C2=O)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O13 compound treatment 106240.0 -8690.0 -0.34 114800.0 -27000.0 -1.01 -0.9549 -0.8941 1583863 TimTec1_005953 CCOC(=O)C1(CCN(Cc2cccc(c2)C(=O)O)CC1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O14 compound treatment 96440.0 -18500.0 -0.72 112920.0 -28900.0 -1.08 -1.2737 -0.9799 3212020 TimTec1_005954 COC(=O)c1c(NC(NC(=O)C)(C(F)(F)F)C(F)(F)F)sc2CN(C)CCc12 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O15 compound treatment 31080.0 -83800.0 -3.25 64920.0 -76900.0 -2.89 -4.3408 -0.9982 1330742 TimTec1_005955 COc1ccc(cc1)C(=O)c2sc3nc(cc(c4cccs4)c3c2N)c5cccs5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O16 compound treatment 15560.0 -99400.0 -3.86 19080.0 -123000.0 -4.61 -5.9831 -0.9961 1008206 TimTec1_005956 NNc1ccc(Br)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O17 compound treatment 82320.0 -32600.0 -1.27 125040.0 -16800.0 -0.63 -1.3394 -0.948 3212021 TimTec1_005957 C/N=C\1/S/C(=C\c2sccc2C)/C(=O)N1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O18 compound treatment 78760.0 -36200.0 -1.4 118720.0 -23100.0 -0.87 -1.6048 -0.9731 1627835 TimTec1_005958 OC(C(=O)NN1CCCCC1)(c2ccsc2)c3ccsc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O19 compound treatment 5480.0 -109000.0 -4.25 8640.0 -133000.0 -5.0 -6.5367 -0.9967 3088220 TimTec1_005959 C/C(=N/O)/C1CCCCCCCCCCC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O20 compound treatment 84800.0 -30100.0 -1.17 123040.0 -18800.0 -0.7 -1.3245 -0.9706 3212022 TimTec1_005960 Fc1cccc(C(=O)N2CCCCC2)c1F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O21 compound treatment 102440.0 -12500.0 -0.48 129200.0 -12600.0 -0.47 -0.677 -0.9999 1373583 TimTec1_005961 Clc1ccc(cc1)C2(CC(=O)N3CCCCC3)C(=O)c4ccccc4C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O22 compound treatment 88000.0 -26900.0 -1.04 133200.0 -8600.0 -0.32 -0.967 -0.8844 1018702 TimTec1_005962 Oc1ccccc1C(=O)N2CCOCC2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O23 mock treatment 110680.0 -4250.0 -0.16 127600.0 -14200.0 -0.53 -0.4934 -0.8844 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 O24 mock treatment 106000.0 -8930.0 -0.35 167200.0 25400.0 0.95 0.4291 0.4231 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P01 compound treatment 5320.0 -110000.0 -4.25 5240.0 -137000.0 -5.13 -6.6314 -0.9957 1707498 TimTec1_005963 COc1ccc(C(=O)c2ccccc2)c(OCC(=O)NC3(CC4CC5CC(C4)C3)C5)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P02 compound treatment 100920.0 -14000.0 -0.54 131960.0 -9840.0 -0.37 -0.6455 -0.9823 3088297 TimTec1_005964 CC1(C)COP(=S)(OC1)N(C2=NCCC2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P03 compound treatment 93640.0 -21300.0 -0.83 120600.0 -21200.0 -0.8 -1.1467 -0.9998 3212023 TimTec1_005965 CCC1CC(O)C(C)C(C)S1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P04 compound treatment 3400.0 -112000.0 -4.33 7120.0 -135000.0 -5.05 -6.6342 -0.997 3088299 TimTec1_005966 Oc1c(Cl)cc(Cl)cc1C(O)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P05 compound treatment 58120.0 -56800.0 -2.2 94600.0 -47200.0 -1.77 -2.8112 -0.9941 1497087 TimTec1_005967 COc1ccccc1n2c(CSc3ccccn3)nc4ccccc4c2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P06 compound treatment 43160.0 -71800.0 -2.78 110320.0 -31500.0 -1.18 -2.8045 -0.9271 3088301 TimTec1_005968 FC(F)(F)c1ccc(cc1)C(=O)NCCc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P07 compound treatment 3000.0 -112000.0 -4.34 6680.0 -135000.0 -5.07 -6.6568 -0.997 3212024 TimTec1_005969 Brc1cccc(CSCC(=O)Nc2ccc3ccccc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P08 compound treatment 53440.0 -61500.0 -2.39 94720.0 -47100.0 -1.77 -2.9364 -0.9891 3212086 TimTec1_005970 Cc1cc(Cl)ccc1OC2C(N(C2=O)c3cccc(c3)C(F)(F)F)c4ccc5OCOc5c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P09 compound treatment 73080.0 -41800.0 -1.62 120200.0 -21600.0 -0.81 -1.7214 -0.9485 1275002 TimTec1_005971 CC(NC(=O)NC1(CC1)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P10 compound treatment 88800.0 -26100.0 -1.01 118880.0 -22900.0 -0.86 -1.3251 -0.9967 1579554 TimTec1_005972 COc1ccc(cc1OC)C2SCC(=O)N2CCN3CCCCC3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P11 compound treatment 5000.0 -110000.0 -4.27 39280.0 -103000.0 -3.85 -5.7368 -0.9987 3088305 TimTec1_005973 CNc1nc(cc(n1)C(F)(F)F)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P12 compound treatment 104800.0 -10100.0 -0.39 115320.0 -26500.0 -0.99 -0.9806 -0.9175 1420064 TimTec1_005974 Fc1ccccc1c2nnn(CC(=O)NCc3ccc4OCOc4c3)n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P13 compound treatment 21440.0 -93500.0 -3.63 43000.0 -98800.0 -3.71 -5.187 -0.9999 1669226 TimTec1_005975 CCOC(=O)C1=C(N)CC(NC1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P14 compound treatment 106080.0 -8850.0 -0.34 121320.0 -20500.0 -0.77 -0.7863 -0.934 3088307 TimTec1_005976 COc1cc(ccc1n2cnnn2)n3cnnn3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P15 compound treatment 85120.0 -29800.0 -1.16 116080.0 -25700.0 -0.97 -1.5004 -0.996 1638981 TimTec1_005977 COc1ccc(NC(=O)C2(CCCCC2)N(C(=O)Cn3nnnc3N)c4ccc(OC)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P16 compound treatment 77720.0 -37200.0 -1.44 109040.0 -32800.0 -1.23 -1.8903 -0.9968 1387660 TimTec1_005978 CN(C)c1ccc(cc1)C(N2C(CC2=O)c3ccco3)C(=O)Nc4c(C)cccc4C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P17 compound treatment 91560.0 -23400.0 -0.91 123080.0 -18700.0 -0.7 -1.1379 -0.9921 1166206 TimTec1_005979 Cc1cc(C)n2nc(nc2n1)S(=O)(=O)N(CC=C)CC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P18 compound treatment 60680.0 -54200.0 -2.1 104200.0 -37600.0 -1.41 -2.4862 -0.9811 3088310 TimTec1_005980 Cc1ccccc1CSc2nnc3c4ccccc4n(CC=C)c3n2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P19 compound treatment 42040.0 -72900.0 -2.83 49600.0 -92200.0 -3.46 -4.4467 -0.995 3212087 TimTec1_005981 CC(=O)NC(NCC1(CC2CC3CC(C2)C1)C3)(C(F)(F)F)C(F)(F)F 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P20 compound treatment 92160.0 -22800.0 -0.88 114520.0 -27300.0 -1.02 -1.3487 -0.9973 3212088 TimTec1_005982 Brc1ccc2nc(oc(=O)c2c1)c3ccc4C(=O)N(C5CCCCC5)C(=O)c4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P21 compound treatment 12480.0 -102000.0 -3.97 44200.0 -97600.0 -3.66 -5.401 -0.9992 1700737 TimTec1_005983 Cc1ccc(cc1S(=O)(=O)NCc2ccccn2)c3nnc(Nc4ccccc4)c5ccccc35 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P22 compound treatment 81760.0 -33200.0 -1.29 83680.0 -58100.0 -2.18 -2.4525 -0.9683 3212089 TimTec1_005984 CN1CCC(CC1)OC(=O)c2cc3cc(Br)ccc3oc2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P23 mock treatment 105040.0 -9890.0 -0.38 139480.0 -2320.0 -0.09 -0.3329 -0.8462 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2079 P24 mock treatment 114560.0 -366.0 -0.01 116040.0 -25800.0 -0.97 -0.6938 -0.7174 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A01 compound treatment 77160.0 -48900.0 -1.9 92120.0 -38800.0 -1.45 -2.3701 -0.9914 3561840 PK04_181001 CC(C)(C)N(CC=C)C(=O)C1N(Cc2ccccc2)C(=O)C3C(C4OC13C=C4)C(=O)O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A02 compound treatment 8080.0 -118000.0 -4.58 4160.0 -127000.0 -4.76 -6.5998 -0.9998 3561841 PK04_181002 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A03 compound treatment 161880.0 35800.0 1.39 132720.0 1840.0 0.07 1.0317 0.7414 3561843 PK04_181003 OC1CCC(CC1)N2C(C(=O)N(CC=C)c3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A04 compound treatment 102680.0 -23400.0 -0.91 78920.0 -52000.0 -1.95 -2.0203 -0.9394 2065615 PK04_181004 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A05 compound treatment 118760.0 -7300.0 -0.28 69360.0 -61500.0 -2.31 -1.8328 -0.7879 3561844 PK04_181005 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccco4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A06 compound treatment 24320.0 -102000.0 -3.95 4560.0 -126000.0 -4.74 -6.1436 -0.9959 3561845 PK04_181006 CCCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)c5ccccc5Cl)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A07 compound treatment 122080.0 -3980.0 -0.15 82080.0 -48800.0 -1.83 -1.4042 -0.764 3561847 PK04_181007 Cc1cccc2OC(CC(=O)c12)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A08 compound treatment 136480.0 10400.0 0.4 61680.0 -69200.0 -2.6 -1.5505 -0.5899 3561848 PK04_181008 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A09 compound treatment 28200.0 -97900.0 -3.8 6200.0 -125000.0 -4.68 -5.9936 -0.9946 3561850 PK04_181009 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A10 compound treatment 23440.0 -103000.0 -3.98 7160.0 -124000.0 -4.64 -6.0987 -0.9971 3561851 PK04_181010 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A11 compound treatment 14080.0 -112000.0 -4.34 6000.0 -125000.0 -4.69 -6.3863 -0.9993 3561853 PK04_181011 Brc1ccc(CN(C(C(=O)NCc2ccccc2)c3ccco3)C(=O)Cc4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A12 compound treatment 149000.0 22900.0 0.89 130080.0 -797.0 -0.03 0.6083 0.683 3561854 PK04_181012 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A13 mock treatment 155720.0 29700.0 1.15 166560.0 35700.0 1.34 1.7608 0.9972 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A14 mock treatment 197480.0 71400.0 2.77 195200.0 64300.0 2.41 3.6666 0.9976 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A15 compound treatment 17840.0 -108000.0 -4.2 8560.0 -122000.0 -4.59 -6.2152 -0.999 3561850 PK04_181013 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A16 compound treatment 185320.0 59300.0 2.3 168640.0 37800.0 1.42 2.6281 0.973 3561856 PK04_181014 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A17 compound treatment 86720.0 -39300.0 -1.53 39760.0 -91100.0 -3.42 -3.4974 -0.9339 3561858 PK04_181015 COc1ccc(CNC(=O)OCC2c3ccccc3-c4ccccc24)cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A18 compound treatment 194880.0 68800.0 2.67 128360.0 -2520.0 -0.09 1.8214 0.6817 3561856 PK04_181016 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A19 compound treatment 184960.0 58900.0 2.29 131160.0 283.0 0.01 1.6236 0.7104 3561859 PK04_181017 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4cc(OC)cc(OC)c4)C(=O)C13)C(=O)NCc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A20 compound treatment 197680.0 71600.0 2.78 165640.0 34800.0 1.3 2.8876 0.9406 3561860 PK04_181018 COc1ccc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A21 compound treatment 12880.0 -113000.0 -4.39 6040.0 -125000.0 -4.69 -6.4182 -0.9995 3561861 PK04_181019 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4ccccc4)C(=O)C13)C(=O)NCc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A22 compound treatment 176120.0 50100.0 1.94 159200.0 28300.0 1.06 2.1252 0.9598 3561862 PK04_181020 COc1cc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)ccc1O[SiH](C(C)C)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A23 compound treatment 7360.0 -119000.0 -4.61 8000.0 -123000.0 -4.61 -6.5176 -1.0 3561864 PK04_181021 O=C(Cc1ccccc1)OC(C(=O)NCc2ccccc2)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 A24 compound treatment 82080.0 -44000.0 -1.71 85040.0 -45800.0 -1.72 -2.423 -1.0 3561865 PK04_181022 COc1cc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)ccc1O[SiH](C(C)C)C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B01 compound treatment 195800.0 69700.0 2.71 162000.0 31100.0 1.17 2.7394 0.9294 3561867 PK04_181023 OC(CC=C)c1cccc(c1)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B02 compound treatment 63240.0 -62800.0 -2.44 13960.0 -117000.0 -4.39 -4.8263 -0.9615 1008566 PK04_181024 Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B03 compound treatment 20440.0 -106000.0 -4.1 6800.0 -124000.0 -4.66 -6.1906 -0.998 3561868 PK04_181025 CC(C)(C)OC(=O)OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B04 compound treatment 7120.0 -119000.0 -4.61 5440.0 -125000.0 -4.71 -6.5921 -1.0 3561869 PK04_181026 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)[Se]c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B05 compound treatment 154800.0 28700.0 1.12 130680.0 -197.0 -0.01 0.7833 0.7024 3561870 PK04_181027 OC(CC1CO1)c2ccc(cc2)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B06 compound treatment 111320.0 -14700.0 -0.57 73600.0 -57300.0 -2.15 -1.9244 -0.8651 3561871 PK04_181028 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B07 compound treatment 8080.0 -118000.0 -4.58 5680.0 -125000.0 -4.7 -6.5594 -0.9999 3561872 PK04_181029 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccc(cc4)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B08 compound treatment 23680.0 -102000.0 -3.97 13640.0 -117000.0 -4.4 -5.9202 -0.9987 3561873 PK04_181030 CC(C)CC1CC(=O)C=C(Cl)N1C(=O)OC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B09 compound treatment 138640.0 12600.0 0.49 116960.0 -13900.0 -0.52 -0.0241 -0.0338 3561874 PK04_181031 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B10 compound treatment 137680.0 11600.0 0.45 148720.0 17800.0 0.67 0.7924 0.9815 3561875 PK04_181032 COC(=O)C1=C(Cl)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B11 compound treatment 8760.0 -117000.0 -4.55 7800.0 -123000.0 -4.62 -6.4845 -1.0 3561876 PK04_181033 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B12 compound treatment 9600.0 -116000.0 -4.52 9680.0 -121000.0 -4.55 -6.4116 -1.0 3561877 PK04_181034 COC(=O)C1=C(OC)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B13 mock treatment 155000.0 28900.0 1.12 162520.0 31600.0 1.19 1.6338 0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B14 mock treatment 140000.0 13900.0 0.54 151520.0 20600.0 0.77 0.9304 0.9846 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B15 compound treatment 113240.0 -12800.0 -0.5 92080.0 -38800.0 -1.46 -1.3813 -0.8977 3561878 PK04_181035 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B16 compound treatment 11320.0 -115000.0 -4.45 8720.0 -122000.0 -4.58 -6.3899 -0.9999 3561879 PK04_181036 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)I 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B17 compound treatment 166960.0 40900.0 1.59 93000.0 -37900.0 -1.42 0.117 0.0549 3561880 PK04_181037 OC(CC1CO1)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B18 compound treatment 179560.0 53500.0 2.08 127040.0 -3840.0 -0.14 1.3661 0.6565 3561881 PK04_181038 CC(C)(C)OC(=O)NCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B19 compound treatment 181000.0 54900.0 2.13 169920.0 39000.0 1.47 2.5436 0.9833 3561882 PK04_181039 CN(CC(O)CC(O)c1ccccc1)Cc2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B20 compound treatment 150560.0 24500.0 0.95 89680.0 -41200.0 -1.55 -0.4211 -0.232 3561883 PK04_181040 COc1ccc(CN(C(=C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B21 compound treatment 44240.0 -81800.0 -3.17 21000.0 -110000.0 -4.12 -5.1608 -0.9916 3561884 PK04_181041 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B22 compound treatment 7440.0 -119000.0 -4.6 5640.0 -125000.0 -4.7 -6.578 -0.9999 3561885 PK04_181042 COc1ccc(CNS(=O)(=O)c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-])c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B23 compound treatment 129560.0 3500.0 0.14 92120.0 -38800.0 -1.45 -0.9325 -0.6383 3561886 PK04_181043 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccncc3)CC(O2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 B24 compound treatment 5040.0 -121000.0 -4.7 3720.0 -127000.0 -4.77 -6.6948 -1.0 3561887 PK04_181044 Brc1ccc(cc1)S(=O)(=O)N2C[C@H]2C=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C01 compound treatment 72240.0 -53800.0 -2.09 56680.0 -74200.0 -2.78 -3.4456 -0.9899 3561889 PK04_181045 O=C(Cc1ccccc1)N2CC(=O)Oc3ccccc23 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C02 compound treatment 135880.0 9820.0 0.38 119600.0 -11300.0 -0.42 -0.0298 -0.0523 3561890 PK04_181046 CCCCCNC(=O)[C@H]1N(C(=O)[C@@H]2[C@H](C3OC12C=C3)C(=O)OCC)c4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C03 compound treatment 112240.0 -13800.0 -0.54 82680.0 -48200.0 -1.81 -1.6582 -0.8789 3561892 PK04_181047 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C04 compound treatment 120840.0 -5220.0 -0.2 106400.0 -24500.0 -0.92 -0.7927 -0.8427 2065568 PK04_181048 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C05 compound treatment 8480.0 -118000.0 -4.56 6760.0 -124000.0 -4.66 -6.5198 -0.9999 3561893 PK04_181049 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)OCC=C)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C06 compound treatment 125520.0 -538.0 -0.02 128840.0 -2040.0 -0.08 -0.0688 -0.8683 2065566 PK04_181050 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C07 compound treatment 122080.0 -3980.0 -0.15 99880.0 -31000.0 -1.16 -0.9318 -0.794 3561894 PK04_181051 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)N(CC=C)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C08 compound treatment 102080.0 -24000.0 -0.93 85000.0 -45900.0 -1.72 -1.8754 -0.9582 2065605 PK04_181052 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2cccs2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C09 compound treatment 117680.0 -8380.0 -0.33 95120.0 -35800.0 -1.34 -1.1788 -0.8537 3561895 PK04_181053 O=C(Cc1ccccc1)OC(COCc2ccccc2)C(=O)NCc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C10 compound treatment 120400.0 -5660.0 -0.22 107120.0 -23800.0 -0.89 -0.7857 -0.8556 2065603 PK04_181054 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3cccs3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C11 mock treatment 122440.0 -3620.0 -0.14 137800.0 6920.0 0.26 0.0845 0.286 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C12 mock treatment 121160.0 -4900.0 -0.19 131720.0 843.0 0.03 -0.112 -0.5813 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C13 compound treatment 129640.0 3580.0 0.14 132600.0 1720.0 0.06 0.144 0.9394 3561896 PK04_181055 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)NCc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C14 compound treatment 120840.0 -5220.0 -0.2 135160.0 4280.0 0.16 -0.0295 -0.1141 2065601 PK04_181056 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3cccs3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C15 mock treatment 125680.0 -378.0 -0.01 124680.0 -6200.0 -0.23 -0.1748 -0.7502 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C16 mock treatment 137080.0 11000.0 0.43 128440.0 -2440.0 -0.09 0.2377 0.5436 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C17 compound treatment 118320.0 -7740.0 -0.3 74840.0 -56000.0 -2.1 -1.6995 -0.7999 3561897 PK04_181057 OC1CCC(CC1)N2C(C(=O)NCc3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C18 compound treatment 114000.0 -12100.0 -0.47 98800.0 -32100.0 -1.2 -1.1821 -0.9152 3057099 PK04_181058 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3ccco3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C19 compound treatment 107680.0 -18400.0 -0.71 53680.0 -77200.0 -2.9 -2.5529 -0.8556 3561892 PK04_181059 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C20 compound treatment 114320.0 -11700.0 -0.46 94360.0 -36500.0 -1.37 -1.2912 -0.894 3057100 PK04_181060 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3ccco3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C21 compound treatment 125560.0 -498.0 -0.02 110000.0 -20900.0 -0.78 -0.5677 -0.7243 3561898 PK04_181061 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=C[C@]42O[C@@H]5/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]4C1=O)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C22 compound treatment 125320.0 -738.0 -0.03 103360.0 -27500.0 -1.03 -0.7505 -0.7264 3176076 PK04_181062 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C23 compound treatment 120600.0 -5460.0 -0.21 114760.0 -16100.0 -0.6 -0.5775 -0.901 3561899 PK04_181063 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 C24 compound treatment 139800.0 13700.0 0.53 80640.0 -50200.0 -1.89 -0.9562 -0.488 2065566 PK04_181064 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D01 compound treatment 140840.0 14800.0 0.57 131400.0 523.0 0.02 0.4194 0.7309 3561900 PK04_181065 COCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D02 compound treatment 144400.0 18300.0 0.71 110400.0 -20500.0 -0.77 -0.0402 -0.0384 3561901 PK04_181066 COc1cc(OC)c(CNS(=O)(=O)c2ccc(Br)cc2)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D03 compound treatment 135160.0 9100.0 0.35 116200.0 -14700.0 -0.55 -0.1398 -0.2136 3561902 PK04_181067 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D04 compound treatment 127720.0 1660.0 0.06 110080.0 -20800.0 -0.78 -0.5063 -0.6465 3561903 PK04_181068 COc1ccc(CN(C(COC(=O)c2cccc(OC)c2O)C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D05 compound treatment 13560.0 -112000.0 -4.36 9400.0 -121000.0 -4.56 -6.3103 -0.9998 3215593 PK04_181069 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)NO)cc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D06 compound treatment 116960.0 -9100.0 -0.35 104560.0 -26300.0 -0.99 -0.948 -0.9038 3561904 PK04_181070 COC(=O)C1CC=C(CC1C(=O)OC)N(Cc2ccc(OC)cc2)S(=O)(=O)c3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D07 compound treatment 99200.0 -26900.0 -1.04 75640.0 -55200.0 -2.07 -2.2028 -0.9494 3561905 PK04_181071 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CN(C)Cc3ccccc3)CC(O2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D08 compound treatment 123400.0 -2660.0 -0.1 136080.0 5200.0 0.2 0.0652 0.2951 3561906 PK04_181072 COc1ccc(CN([C@H](COC(=O)c2ccc(cc2)[N+](=O)[O-])C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D09 compound treatment 104560.0 -21500.0 -0.83 77680.0 -53200.0 -2.0 -2.0016 -0.925 3561908 PK04_181073 OC(CSc1nc2ccccc2o1)CC(O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D10 compound treatment 111120.0 -14900.0 -0.58 110800.0 -20100.0 -0.75 -0.9426 -0.9916 3561909 PK04_181074 Brc1ccc(cc1)N2C(CN(C2=O)S(=O)(=O)c3ccc(Br)cc3)C=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D11 mock treatment 139320.0 13300.0 0.51 145600.0 14700.0 0.55 0.7546 0.9994 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D12 mock treatment 142960.0 16900.0 0.66 138080.0 7200.0 0.27 0.6549 0.9232 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D13 compound treatment 124560.0 -1500.0 -0.06 130600.0 -277.0 -0.01 -0.0484 -0.8205 3561910 PK04_181075 COC(=O)CCCCCCC(=O)NOCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D14 compound treatment 110480.0 -15600.0 -0.6 105440.0 -25400.0 -0.95 -1.1025 -0.9757 3561911 PK04_181076 COc1ccc(CN([C@H](CI)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D15 mock treatment 142960.0 16900.0 0.66 145160.0 14300.0 0.54 0.8428 0.995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D16 mock treatment 136200.0 10100.0 0.39 128520.0 -2360.0 -0.09 0.2157 0.5348 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D17 compound treatment 130800.0 4740.0 0.18 125880.0 -5000.0 -0.19 -0.0025 -0.0095 3561913 PK04_181077 OC(=O)CCCCCCC(=O)NOCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D18 compound treatment 129080.0 3020.0 0.12 114160.0 -16700.0 -0.63 -0.3607 -0.5652 3561914 PK04_181078 COc1ccc(CN(C2=CCC3C(C2)C(=O)N(C)C3=O)S(=O)(=O)c4ccc(Br)cc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D19 compound treatment 135880.0 9820.0 0.38 123520.0 -7360.0 -0.28 0.0742 0.1577 3561915 PK04_181079 OCc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D20 compound treatment 30760.0 -95300.0 -3.7 29480.0 -101000.0 -3.81 -5.3055 -0.9999 3561916 PK04_181080 COCCCN(CC(O)CO)C[C@]1(O)CCC2[C@]1(C)CCC3[C@@]4(C)CC[C@H](O)C[C@@]54C=C[C@]23C(=C5)C(=O)c6ccc(OC)cc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D21 compound treatment 135040.0 8980.0 0.35 112760.0 -18100.0 -0.68 -0.2344 -0.3067 3561917 PK04_181081 O=Cc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D22 compound treatment 127280.0 1220.0 0.05 108000.0 -22900.0 -0.86 -0.5736 -0.667 3561918 PK04_181082 COCCCN(CC(O)CO)C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D23 compound treatment 125680.0 -378.0 -0.01 99680.0 -31200.0 -1.17 -0.8383 -0.7159 3561919 PK04_181083 OC(CN=[N+]=[N-])CC(O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 D24 compound treatment 104200.0 -21900.0 -0.85 66080.0 -64800.0 -2.43 -2.3193 -0.9005 3561920 PK04_181084 COCCCN(C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C)C(=O)O[C@H]5C[C@@H](C)CC[C@@H]5C(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E01 mock treatment 149920.0 23900.0 0.93 112440.0 -18400.0 -0.69 0.1654 0.1431 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E02 mock treatment 132600.0 6540.0 0.25 122600.0 -8280.0 -0.31 -0.0402 -0.1001 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E03 compound treatment 116640.0 -9420.0 -0.37 97640.0 -33200.0 -1.25 -1.1405 -0.8774 3561899 PK04_181085 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E04 compound treatment 65280.0 -60800.0 -2.36 61240.0 -69600.0 -2.61 -3.5156 -0.9987 2065568 PK04_181086 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E05 compound treatment 105480.0 -20600.0 -0.8 111800.0 -19100.0 -0.72 -1.0708 -0.9985 3561899 PK04_181087 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E06 compound treatment 131880.0 5820.0 0.23 119280.0 -11600.0 -0.44 -0.148 -0.3019 2065570 PK04_181088 O=C(NCc1ccccc1)C(COCc2ccccc2)OC(=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E07 compound treatment 118960.0 -7100.0 -0.28 106040.0 -24800.0 -0.93 -0.8539 -0.8785 3561899 PK04_181089 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E08 compound treatment 119560.0 -6500.0 -0.25 118960.0 -11900.0 -0.45 -0.4945 -0.9632 2065572 PK04_181090 COc1ccc(NC(=O)C(COCc2ccccc2)OC(=O)c3ccccc3)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E09 mock treatment 129240.0 3180.0 0.12 134600.0 3720.0 0.14 0.1861 0.9981 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E10 mock treatment 132760.0 6700.0 0.26 132800.0 1920.0 0.07 0.2349 0.8705 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E11 compound treatment 101000.0 -25100.0 -0.97 87600.0 -43300.0 -1.62 -1.836 -0.9699 3561921 PK04_181091 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E12 compound treatment 127240.0 1180.0 0.05 139440.0 8560.0 0.32 0.2597 0.7999 2065574 PK04_181092 CC(C)(C)NC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E13 compound treatment 121760.0 -4300.0 -0.17 129400.0 -1480.0 -0.06 -0.1571 -0.894 3561922 PK04_181093 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(Cc4ccc(OC)cc4)C(=O)[C@@H]13)C(=O)NCc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E14 compound treatment 131320.0 5260.0 0.2 121280.0 -9600.0 -0.36 -0.1103 -0.2664 2065576 PK04_181094 CCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E15 compound treatment 134000.0 7940.0 0.31 128880.0 -2000.0 -0.07 0.1649 0.52 3561841 PK04_181095 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E16 compound treatment 129640.0 3580.0 0.14 134160.0 3280.0 0.12 0.1854 0.9982 2065599 PK04_181096 CCCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E17 mock treatment 138120.0 12100.0 0.47 131760.0 883.0 0.03 0.3544 0.7553 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E18 mock treatment 137600.0 11500.0 0.45 140840.0 9960.0 0.37 0.5811 0.996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E19 compound treatment 128840.0 2780.0 0.11 125760.0 -5120.0 -0.19 -0.0595 -0.2699 3561841 PK04_181097 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E20 compound treatment 131520.0 5460.0 0.21 126200.0 -4680.0 -0.18 0.0257 0.0935 3561923 PK04_181098 CCCNC(=O)COc1ccc(C=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E21 compound treatment 116800.0 -9260.0 -0.36 113400.0 -17500.0 -0.66 -0.7178 -0.9598 3561841 PK04_181099 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E22 compound treatment 142720.0 16700.0 0.65 117880.0 -13000.0 -0.49 0.1122 0.1386 3561924 PK04_181100 CCCNC(=O)Cc1ccc(N)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E23 compound treatment 116120.0 -9940.0 -0.39 114600.0 -16300.0 -0.61 -0.7046 -0.9754 3561841 PK04_181101 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 E24 compound treatment 143920.0 17900.0 0.69 118480.0 -12400.0 -0.47 0.1611 0.193 3561925 PK04_181102 CCOC(=O)/C=C/c1ccccc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F01 mock treatment 147680.0 21600.0 0.84 124400.0 -6480.0 -0.24 0.4213 0.4824 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F02 mock treatment 130960.0 4900.0 0.19 126720.0 -4160.0 -0.16 0.0242 0.0983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F03 compound treatment 9600.0 -116000.0 -4.52 9240.0 -122000.0 -4.57 -6.4232 -1.0 3561927 PK04_181103 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F04 compound treatment 113000.0 -13100.0 -0.51 118160.0 -12700.0 -0.48 -0.6957 -0.9996 1366116 PK04_181104 Brc1ccc2ncnc(NCC=C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F05 compound treatment 123680.0 -2380.0 -0.09 124240.0 -6640.0 -0.25 -0.2414 -0.9087 3561928 PK04_181105 CN(CC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F06 compound treatment 10600.0 -115000.0 -4.48 9760.0 -121000.0 -4.55 -6.382 -1.0 1945167 PK04_181106 C/C(=C/C(=O)c1ccc(Cl)cc1)/Nc2cccc(O)c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F07 compound treatment 134120.0 8060.0 0.31 128120.0 -2760.0 -0.1 0.148 0.4493 3561929 PK04_181107 OC(CSc1nc2ccccc2s1)CC(O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F08 compound treatment 136280.0 10200.0 0.4 141040.0 10200.0 0.38 0.5502 0.9998 1448632 PK04_181108 Nn1cnc2-c3ccccc3CC4(CCCC4)c2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F09 mock treatment 136720.0 10700.0 0.41 144720.0 13800.0 0.52 0.6599 0.9936 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F10 mock treatment 121400.0 -4660.0 -0.18 140400.0 9520.0 0.36 0.1249 0.312 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F11 compound treatment 131440.0 5380.0 0.21 138920.0 8040.0 0.3 0.3611 0.9838 3561930 PK04_181109 OC(CSc1ccccn1)CC(O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F12 compound treatment 125880.0 -178.0 -0.01 133360.0 2480.0 0.09 0.061 0.653 3561931 PK04_181110 [O-][N+](=O)c1ccccc1/C=C/c2ccncc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F13 compound treatment 33520.0 -92500.0 -3.59 39440.0 -91400.0 -3.43 -4.9655 -0.9997 3561933 PK04_181111 ONC(=O)CCCCCCC(=O)NOCc1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F14 compound treatment 130120.0 4060.0 0.16 136880.0 6000.0 0.23 0.2708 0.9847 1679359 PK04_181112 OC(=O)CCCN1C(=O)CSC1=S 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F15 compound treatment 130240.0 4180.0 0.16 126480.0 -4400.0 -0.17 -0.0019 -0.0084 1020755 PK04_181113 O=C(C[n+]1ccc2ccccc2c1)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F16 compound treatment 131160.0 5100.0 0.2 125040.0 -5840.0 -0.22 -0.0149 -0.0505 3561934 PK04_181114 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F17 mock treatment 138080.0 12000.0 0.47 135480.0 4600.0 0.17 0.452 0.9087 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F18 mock treatment 136560.0 10500.0 0.41 135640.0 4760.0 0.18 0.4145 0.9316 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F19 compound treatment 113840.0 -12200.0 -0.47 110120.0 -20800.0 -0.78 -0.8861 -0.9716 3561936 PK04_181115 Brc1c2OCOc2ccc1C[n+]3ccc4ccccc4c3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F20 compound treatment 55200.0 -70900.0 -2.75 47320.0 -83600.0 -3.14 -4.1616 -0.9978 3561937 PK04_181116 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2/C=C/c3ccncc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F21 compound treatment 118760.0 -7300.0 -0.28 114640.0 -16200.0 -0.61 -0.6311 -0.9392 3561939 PK04_181117 CC(C)(C)[Si](C)(C)Oc1ccc2cc[n+](Cc3ccccc3Br)cc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F22 compound treatment 95000.0 -31100.0 -1.21 78360.0 -52500.0 -1.97 -2.2458 -0.9721 1936946 PK04_181118 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F23 compound treatment 117840.0 -8220.0 -0.32 107560.0 -23300.0 -0.88 -0.8443 -0.9064 3561940 PK04_181119 COc1ccc(Br)c(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 F24 compound treatment 114800.0 -11300.0 -0.44 85080.0 -45800.0 -1.72 -1.5243 -0.8595 3561941 PK04_181120 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G01 compound treatment 155760.0 29700.0 1.15 148120.0 17200.0 0.65 1.2725 0.9628 3561841 PK04_181121 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G02 compound treatment 120520.0 -5540.0 -0.21 95160.0 -35700.0 -1.34 -1.0998 -0.8101 3561943 PK04_181122 O=C1CSC(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G03 mock treatment 124120.0 -1940.0 -0.08 121600.0 -9280.0 -0.35 -0.2994 -0.8404 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G04 mock treatment 139800.0 13700.0 0.53 131120.0 243.0 0.01 0.3835 0.7191 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G05 compound treatment 74560.0 -51500.0 -2.0 73160.0 -57700.0 -2.17 -2.9446 -0.9992 PK04_181123 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G06 compound treatment 125240.0 -818.0 -0.03 111960.0 -18900.0 -0.71 -0.5245 -0.738 3561944 PK04_181124 CC(C)(C)c1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G07 compound treatment 114640.0 -11400.0 -0.44 126960.0 -3920.0 -0.15 -0.4172 -0.8938 PK04_181125 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G08 compound treatment 114960.0 -11100.0 -0.43 127080.0 -3800.0 -0.14 -0.4052 -0.8935 3561945 PK04_181126 CCOC(=O)/C=C(\C)/c1ccccc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G09 compound treatment 114160.0 -11900.0 -0.46 119000.0 -11900.0 -0.45 -0.6416 -0.9998 3561841 PK04_181127 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G10 compound treatment 126920.0 862.0 0.03 122680.0 -8200.0 -0.31 -0.1939 -0.6265 3561947 PK04_181128 CCOC(=O)/C=C/c1c(OC)cccc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G11 compound treatment 46840.0 -79200.0 -3.07 54280.0 -76600.0 -2.87 -4.2062 -0.9994 3561899 PK04_181129 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G12 compound treatment 120200.0 -5860.0 -0.23 132480.0 1600.0 0.06 -0.1182 -0.5026 3561949 PK04_181130 CCCNC(=O)Cc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G13 compound treatment 66440.0 -59600.0 -2.31 80200.0 -50700.0 -1.9 -2.9806 -0.9953 3561950 PK04_181131 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)c6cccc(Cl)c6CO)c7ccccc7 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G14 compound treatment 119120.0 -6940.0 -0.27 121920.0 -8960.0 -0.34 -0.428 -0.9939 3561952 PK04_181132 COc1cc(/C=C/CO)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G15 compound treatment 95400.0 -30700.0 -1.19 106040.0 -24800.0 -0.93 -1.5003 -0.9927 3561841 PK04_181133 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G16 compound treatment 123840.0 -2220.0 -0.09 133240.0 2360.0 0.09 0.0019 0.0151 3561954 PK04_181134 COc1ccccc1/C=C/CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G17 compound treatment 115000.0 -11100.0 -0.43 108240.0 -22600.0 -0.85 -0.9041 -0.9499 3561956 PK04_181135 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G18 compound treatment 98400.0 -27700.0 -1.07 92520.0 -38400.0 -1.44 -1.7768 -0.9895 3561958 PK04_181136 O=C1CS(=O)(=O)C(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G19 mock treatment 132800.0 6740.0 0.26 122400.0 -8480.0 -0.32 -0.04 -0.0971 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G20 mock treatment 123920.0 -2140.0 -0.08 130760.0 -117.0 0.0 -0.0618 -0.7434 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G21 compound treatment 82960.0 -43100.0 -1.67 79760.0 -51100.0 -1.92 -2.539 -0.9977 3561959 PK04_181137 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G22 compound treatment 92560.0 -33500.0 -1.3 93920.0 -37000.0 -1.39 -1.8998 -0.9995 3561961 PK04_181138 CC(C)(C)c1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G23 compound treatment 91240.0 -34800.0 -1.35 77120.0 -53800.0 -2.02 -2.3819 -0.981 3561959 PK04_181139 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 G24 compound treatment 134880.0 8820.0 0.34 125960.0 -4920.0 -0.18 0.1116 0.2869 2093329 PK04_181140 COC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H01 compound treatment 128080.0 2020.0 0.08 131280.0 403.0 0.02 0.0662 0.8282 3561962 PK04_181141 Brc1ccccc1C(=O)[n+]2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H02 compound treatment 94160.0 -31900.0 -1.24 91280.0 -39600.0 -1.49 -1.926 -0.9959 3561963 PK04_181142 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)O)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H03 mock treatment 138640.0 12600.0 0.49 153640.0 22800.0 0.85 0.9493 0.9648 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H04 mock treatment 131720.0 5660.0 0.22 130000.0 -877.0 -0.03 0.1321 0.5946 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H05 compound treatment 43080.0 -83000.0 -3.22 57920.0 -73000.0 -2.74 -4.2128 -0.9968 3561965 PK04_181143 COc1cc2CC[N+](=Cc2cc1O[Si](C)(C)C(C)(C)C)Cc3ccccc3Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H06 compound treatment 47920.0 -78100.0 -3.03 47000.0 -83900.0 -3.15 -4.3698 -0.9998 3561966 PK04_181144 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H07 compound treatment 121680.0 -4380.0 -0.17 150480.0 19600.0 0.74 0.4001 0.5299 3561968 PK04_181145 COc1cc2CC[N+](=Cc2cc1OC)C(=O)c3ccccc3Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H08 compound treatment 108480.0 -17600.0 -0.68 112160.0 -18700.0 -0.7 -0.979 -0.9999 3561969 PK04_181146 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3C4CC5CC(C4)CC3C5)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H09 compound treatment 10360.0 -116000.0 -4.49 10000.0 -121000.0 -4.54 -6.3822 -1.0 3561971 PK04_181147 Oc1ccc2CCN(Cc3ccccc3Br)C(C=C)c2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H10 compound treatment 46800.0 -79300.0 -3.08 59280.0 -71600.0 -2.69 -4.0746 -0.9977 3561972 PK04_181148 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(O)(C4)C3)C5)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H11 compound treatment 115240.0 -10800.0 -0.42 128160.0 -2720.0 -0.1 -0.3689 -0.854 3561974 PK04_181149 Brc1c[n+](Cc2ccccc2)cc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H12 compound treatment 50360.0 -75700.0 -2.94 68400.0 -62500.0 -2.34 -3.7349 -0.9938 3561975 PK04_181150 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NCC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H13 compound treatment 105880.0 -20200.0 -0.78 115120.0 -15800.0 -0.59 -0.9718 -0.9904 3561977 PK04_181151 COc1ccc(Br)c(C[n+]2cc(Br)c3ccccc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H14 compound treatment 97760.0 -28300.0 -1.1 92160.0 -38700.0 -1.45 -1.8039 -0.9904 3561978 PK04_181152 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H15 compound treatment 119120.0 -6940.0 -0.27 133480.0 2600.0 0.1 -0.1213 -0.4234 1003512 PK04_181153 C[n+]1ccc2ccccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H16 compound treatment 41480.0 -84600.0 -3.28 49040.0 -81800.0 -3.07 -4.4923 -0.9995 3561980 PK04_181154 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H17 compound treatment 128800.0 2740.0 0.11 124240.0 -6640.0 -0.25 -0.1009 -0.3725 1032420 PK04_181155 C(c1ccccc1)[n+]2ccc3ccccc3c2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H18 compound treatment 79240.0 -46800.0 -1.82 89080.0 -41800.0 -1.57 -2.3937 -0.9973 3561982 PK04_181156 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H19 mock treatment 136560.0 10500.0 0.41 138360.0 7480.0 0.28 0.4867 0.9835 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H20 mock treatment 118160.0 -7900.0 -0.31 120560.0 -10300.0 -0.39 -0.4905 -0.9933 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H21 compound treatment 90840.0 -35200.0 -1.37 98960.0 -31900.0 -1.2 -1.8133 -0.9978 3561984 PK04_181157 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H22 compound treatment 8440.0 -118000.0 -4.56 9280.0 -122000.0 -4.56 -6.454 -1.0 3561985 PK04_181158 O=C1C=C[C@@H]2[C@@H]3C=C[C@H]([C@@H]2[C@]41CO4)[C@@]5(CO5)C3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H23 compound treatment 5440.0 -121000.0 -4.68 5200.0 -126000.0 -4.72 -6.6446 -1.0 3561987 PK04_181159 COc1ccc(Br)c(C[n+]2ccc3c(cccc3c2)[N+](=O)[O-])c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 H24 compound treatment 103040.0 -23000.0 -0.89 108720.0 -22200.0 -0.83 -1.2195 -0.9994 3561988 PK04_181160 CC1(C)C[C@H]2C[C@H]3C(=C[C@]2(CO1)C(=O)[C@@]43CO4)Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I01 compound treatment 41600.0 -84500.0 -3.28 47280.0 -83600.0 -3.14 -4.5357 -0.9998 3561956 PK04_181161 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I02 compound treatment 141840.0 15800.0 0.61 124680.0 -6200.0 -0.23 0.2685 0.41 3561990 PK04_181162 CCCNC(=O)Cc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I03 compound treatment 40200.0 -85900.0 -3.33 39720.0 -91200.0 -3.42 -4.7748 -0.9999 3561991 PK04_181163 OCc1c(Cl)cccc1N2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OCC=C)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I04 compound treatment 132920.0 6860.0 0.27 128760.0 -2120.0 -0.08 0.1321 0.4754 3561993 PK04_181164 COc1ccccc1/C(=C/CO)/C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I05 mock treatment 127200.0 1140.0 0.04 130040.0 -837.0 -0.03 0.0091 0.1681 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I06 mock treatment 120000.0 -6060.0 -0.24 125320.0 -5560.0 -0.21 -0.3137 -0.9982 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I07 compound treatment 70280.0 -55800.0 -2.16 80400.0 -50500.0 -1.89 -2.8699 -0.9978 3561995 PK04_181165 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I08 compound treatment 116040.0 -10000.0 -0.39 131800.0 923.0 0.03 -0.2503 -0.6415 3561996 PK04_181166 COc1ccccc1/C(=C/C=O)/C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I09 compound treatment 116600.0 -9460.0 -0.37 125640.0 -5240.0 -0.2 -0.3985 -0.9572 3561998 PK04_181167 OCc1c(Cl)cccc1N2[C@@H](C(=O)NCc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)O)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I10 compound treatment 56960.0 -69100.0 -2.68 68880.0 -62000.0 -2.33 -3.5411 -0.9975 2069262 PK04_181168 COc1cc(/C=C/C=O)cc(OC)c1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I11 compound treatment 88040.0 -38000.0 -1.48 113320.0 -17600.0 -0.66 -1.509 -0.934 3562000 PK04_181169 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4ccccc4Cl)C(=O)N(CC=C)Cc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I12 compound treatment 132560.0 6500.0 0.25 129840.0 -1040.0 -0.04 0.1509 0.5911 3562002 PK04_181170 CCOC(=O)/C=C/c1cccc(c1)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I13 compound treatment 110160.0 -15900.0 -0.62 121640.0 -9240.0 -0.35 -0.6813 -0.9629 3562003 PK04_181171 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N(Cc4ccccc4)[C@@H]5C(=O)N(Cc6ccccc6)CC=C[C@]35O[C@@H]2/C=C/CCC(=O)N1C)c7ccccc7 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I14 compound treatment 108560.0 -17500.0 -0.68 121240.0 -9640.0 -0.36 -0.7358 -0.9565 3562005 PK04_181172 COc1cccc(OC)c1/C=C/CO 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I15 compound treatment 74960.0 -51100.0 -1.98 96400.0 -34500.0 -1.29 -2.3169 -0.9786 3562007 PK04_181173 CCCCNC(=O)[C@@H]1N(C2CCCCC2)C(=O)[C@H]3[C@@H]([C@H]4O[C@@]13C=C4)C(=O)OCC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I16 compound treatment 115960.0 -10100.0 -0.39 127840.0 -3040.0 -0.11 -0.3576 -0.8765 3562009 PK04_181174 Clc1cccc(c1)N2C(SCC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I17 compound treatment 63800.0 -62300.0 -2.42 97520.0 -33400.0 -1.25 -2.5934 -0.9532 3561995 PK04_181175 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I18 compound treatment 119680.0 -6380.0 -0.25 119680.0 -11200.0 -0.42 -0.4721 -0.9681 3065130 PK04_181176 Clc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I19 compound treatment 121360.0 -4700.0 -0.18 136440.0 5560.0 0.21 0.0188 0.0677 3562010 PK04_181177 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I20 compound treatment 138280.0 12200.0 0.47 120520.0 -10400.0 -0.39 0.0605 0.0986 3562012 PK04_181178 OC/C=C/c1cccc(c1)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I21 mock treatment 126600.0 542.0 0.02 135720.0 4840.0 0.18 0.1434 0.7837 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I22 mock treatment 120040.0 -6020.0 -0.23 122120.0 -8760.0 -0.33 -0.3975 -0.986 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I23 compound treatment 27240.0 -98800.0 -3.83 20480.0 -110000.0 -4.14 -5.641 -0.9992 3562014 PK04_181179 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N([C@@H]4C(=O)N(Cc5ccccc5)CC=C[C@]34O[C@@H]2/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 I24 compound treatment 5440.0 -121000.0 -4.68 5200.0 -126000.0 -4.72 -6.6446 -1.0 3215604 PK04_181180 O=C/1N(C(c2ccccc2)S(=O)(=O)\C1=C/c3ccc4ccccc4c3)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J01 compound treatment 97720.0 -28300.0 -1.1 109280.0 -21600.0 -0.81 -1.3506 -0.9888 3562016 PK04_181181 COc1ccc(Br)c(C[n+]2ccccc2C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J02 compound treatment 6840.0 -119000.0 -4.63 17880.0 -113000.0 -4.24 -6.2697 -0.9991 3562017 PK04_181182 OCCCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J03 compound treatment 71640.0 -54400.0 -2.11 92400.0 -38500.0 -1.44 -2.5141 -0.9828 3562019 PK04_181183 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J04 compound treatment 36880.0 -89200.0 -3.46 55840.0 -75000.0 -2.82 -4.4381 -0.9948 3562020 PK04_181184 OCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J05 mock treatment 120280.0 -5780.0 -0.22 131040.0 163.0 0.01 -0.1542 -0.6875 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J06 mock treatment 126760.0 702.0 0.03 140360.0 9480.0 0.36 0.2709 0.759 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J07 compound treatment 110200.0 -15900.0 -0.62 127240.0 -3640.0 -0.14 -0.5316 -0.8435 3562022 PK04_181185 Cc1[n+](Cc2ccccc2)ccc3ccccc13 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J08 compound treatment 9160.0 -117000.0 -4.54 10000.0 -121000.0 -4.54 -6.4151 -1.0 3562023 PK04_181186 BrC1=C[C@@]2(Br)[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J09 compound treatment 88240.0 -37800.0 -1.47 96880.0 -34000.0 -1.28 -1.9398 -0.9976 3562025 PK04_181187 COc1ccc(Br)c(C[n+]2cccc3cc(OC)ccc23)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J10 compound treatment 9120.0 -117000.0 -4.54 9480.0 -121000.0 -4.56 -6.43 -1.0 3562026 PK04_181188 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@]2(Br)C(=O)[C@@]43CO4)Br 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J11 compound treatment 90600.0 -35500.0 -1.38 118760.0 -12100.0 -0.45 -1.2944 -0.8933 3562028 PK04_181189 COc1ccc(Br)c(C[N+]2=C(C)CCC2)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J12 compound treatment 85640.0 -40400.0 -1.57 90680.0 -40200.0 -1.51 -2.1757 -0.9998 3562029 PK04_181190 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J13 compound treatment 59760.0 -66300.0 -2.57 61160.0 -69700.0 -2.62 -3.6692 -1.0 3562031 PK04_181191 COc1ccc(Br)c(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J14 compound treatment 109120.0 -16900.0 -0.66 111920.0 -19000.0 -0.71 -0.9678 -0.9992 3562032 PK04_181192 COc1ccc(CCNC(=O)[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J15 compound treatment 114280.0 -11800.0 -0.46 126760.0 -4120.0 -0.15 -0.4324 -0.8963 3562033 PK04_181193 COC(CN(Cc1cccc(OC)c1)S(=O)(=O)c2ccc(C)cc2)OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J16 compound treatment 71240.0 -54800.0 -2.13 103720.0 -27200.0 -1.02 -2.2247 -0.9432 3562034 PK04_181194 COc1ccc(CCN2C(=O)C3(CC(=O)N(Cc4ccccc4)C3c5ccccc5)c6cc(ccc26)[N+](=O)[O-])cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J17 compound treatment 119080.0 -6980.0 -0.27 126680.0 -4200.0 -0.16 -0.3028 -0.9668 3562035 PK04_181195 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J18 compound treatment 83520.0 -42500.0 -1.65 95760.0 -35100.0 -1.32 -2.099 -0.9938 3562036 PK04_181196 C[C@@]1(CCc2ccccc2)C[C@@H](C[Si](C)(C)C(c3ccccc3)c4ccccc4)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J19 compound treatment 57840.0 -68200.0 -2.65 62640.0 -68200.0 -2.56 -3.6826 -0.9999 3562038 PK04_181197 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J20 compound treatment 81640.0 -44400.0 -1.72 96520.0 -34400.0 -1.29 -2.1304 -0.9898 3562039 PK04_181198 CCCCCCC1C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J21 mock treatment 123080.0 -2980.0 -0.12 125400.0 -5480.0 -0.21 -0.227 -0.9629 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J22 mock treatment 128320.0 2260.0 0.09 117800.0 -13100.0 -0.49 -0.285 -0.5716 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J23 compound treatment 29080.0 -97000.0 -3.76 42040.0 -88800.0 -3.33 -5.0183 -0.9982 3562041 PK04_181199 COc1cc2CCN(CC=C)C(C#Cc3ccccc3)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 J24 compound treatment 72960.0 -53100.0 -2.06 89400.0 -41500.0 -1.56 -2.5575 -0.9904 3562042 PK04_181200 Cc1ccc(cc1)C2C[C@]3(CC[C@@H](CC3)C(C)(C)C)OO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K01 compound treatment 80560.0 -45500.0 -1.77 132400.0 1520.0 0.06 -1.2078 -0.6838 3562010 PK04_181201 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K02 compound treatment 106000.0 -20100.0 -0.78 112320.0 -18600.0 -0.7 -1.0428 -0.9985 3215602 PK04_181202 Cc1c(NC(=O)/C(=C/c2ccc3ccccc3c2)/C#N)c(=O)n(c4ccccc4)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K03 compound treatment 22320.0 -104000.0 -4.03 49680.0 -81200.0 -3.05 -5.001 -0.9906 3562044 PK04_181203 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K04 compound treatment 66080.0 -60000.0 -2.33 77480.0 -53400.0 -2.0 -3.0626 -0.9972 3562046 PK04_181204 COc1cccc(OC)c1/C=C/C=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K05 compound treatment 6640.0 -119000.0 -4.63 8480.0 -122000.0 -4.59 -6.5246 -1.0 2065615 PK04_181205 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K06 compound treatment 74800.0 -51300.0 -1.99 83240.0 -47600.0 -1.79 -2.6705 -0.9986 3562048 PK04_181206 Clc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K07 mock treatment 114800.0 -11300.0 -0.44 124520.0 -6360.0 -0.24 -0.4776 -0.9595 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K08 mock treatment 119000.0 -7060.0 -0.27 136160.0 5280.0 0.2 -0.0534 -0.158 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K09 compound treatment 10040.0 -116000.0 -4.5 14040.0 -117000.0 -4.39 -6.2838 -0.9999 3562049 PK04_181207 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K10 compound treatment 108480.0 -17600.0 -0.68 112040.0 -18800.0 -0.71 -0.9822 -0.9998 3562051 PK04_181208 Clc1cccc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K11 compound treatment 10360.0 -116000.0 -4.49 13640.0 -117000.0 -4.4 -6.2856 -0.9999 3562052 PK04_181209 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K12 compound treatment 117880.0 -8180.0 -0.32 133120.0 2240.0 0.08 -0.1648 -0.5021 3562054 PK04_181210 O=C1CSCN1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K13 compound treatment 76920.0 -49100.0 -1.91 97160.0 -33700.0 -1.27 -2.2429 -0.9802 3562052 PK04_181211 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K14 compound treatment 129120.0 3060.0 0.12 123480.0 -7400.0 -0.28 -0.1123 -0.3719 1951450 PK04_181212 Cc1c(N2C(SCC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K15 mock treatment 127440.0 1380.0 0.05 131440.0 563.0 0.02 0.0529 0.9171 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K16 mock treatment 112800.0 -13300.0 -0.51 121120.0 -9760.0 -0.37 -0.6227 -0.9861 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K17 compound treatment 7720.0 -118000.0 -4.59 9720.0 -121000.0 -4.55 -6.4621 -1.0 3562052 PK04_181213 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K18 compound treatment 115000.0 -11100.0 -0.43 114800.0 -16100.0 -0.6 -0.73 -0.986 3562055 PK04_181214 CN1C(SCC1=O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K19 compound treatment 13520.0 -113000.0 -4.37 18280.0 -113000.0 -4.23 -6.0758 -0.9999 3562056 PK04_181215 COCOc1ccc2cc(Br)ccc2c1c3c(OCOC)ccc4cc(Br)ccc34 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K20 compound treatment 122600.0 -3460.0 -0.13 118720.0 -12200.0 -0.46 -0.4175 -0.8779 3562057 PK04_181216 O=C1CS(=O)(=O)CN1c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K21 compound treatment 7360.0 -119000.0 -4.61 8360.0 -123000.0 -4.6 -6.5081 -1.0 3220192 PK04_181217 CC(CO)N1C2C(=O)N(Cc3ccccc3)CC=CC42OC5C=CCOC(=O)C5C4C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K22 compound treatment 107280.0 -18800.0 -0.73 129280.0 -1600.0 -0.06 -0.5576 -0.7627 3562058 PK04_181218 CN1C(c2ccccc2)S(=O)(=O)CC1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K23 mock treatment 106800.0 -19300.0 -0.75 123200.0 -7680.0 -0.29 -0.7321 -0.9142 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 K24 mock treatment 114840.0 -11200.0 -0.44 155880.0 25000.0 0.94 0.3558 0.3439 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L01 compound treatment 99640.0 -26400.0 -1.03 130160.0 -717.0 -0.03 -0.7438 -0.7254 3562059 PK04_181219 COc1cc2CC[N+](=Cc2cc1OC)Cc3ccc(Br)cc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L02 compound treatment 54800.0 -71300.0 -2.76 75680.0 -55200.0 -2.07 -3.4199 -0.9899 3562060 PK04_181220 CCOC(=O)CCC1(C)C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L03 compound treatment 59000.0 -67100.0 -2.6 64920.0 -66000.0 -2.48 -3.5902 -0.9997 3562062 PK04_181221 Cc1cc2ccccc2c[n+]1CCCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L04 compound treatment 4520.0 -122000.0 -4.72 5600.0 -125000.0 -4.7 -6.6592 -1.0 3562063 PK04_181222 CC1(CCc2ccccc2)CC(CO)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L05 compound treatment 57040.0 -69000.0 -2.68 77000.0 -53900.0 -2.02 -3.3234 -0.9904 3562064 PK04_181223 COc1ccc(Br)c(C[n+]2cc3ccccc3cc2C)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L06 compound treatment 10280.0 -116000.0 -4.49 9000.0 -122000.0 -4.57 -6.411 -1.0 3562065 PK04_181224 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CC(C)(C)CO)OO2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L07 mock treatment 110200.0 -15900.0 -0.62 120600.0 -10300.0 -0.39 -0.7078 -0.9747 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L08 mock treatment 128840.0 2780.0 0.11 130280.0 -597.0 -0.02 0.0605 0.5487 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L09 compound treatment 107520.0 -18500.0 -0.72 120960.0 -9920.0 -0.37 -0.7718 -0.953 3562067 PK04_181225 CC1=[N+](C)C2C3CC=CC3C1c4ccccc24 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L10 compound treatment 10640.0 -115000.0 -4.48 57520.0 -73400.0 -2.75 -5.1134 -0.9727 3562068 PK04_181226 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L11 compound treatment 114400.0 -11700.0 -0.45 120120.0 -10800.0 -0.4 -0.6053 -0.9984 1006359 PK04_181227 Cc1cccc[n+]1C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L12 compound treatment 86160.0 -39900.0 -1.55 84480.0 -46400.0 -1.74 -2.326 -0.9983 3562070 PK04_181228 CC1(CCOCc2ccccc2)CC(C)(CCc3ccccc3)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L13 compound treatment 113120.0 -12900.0 -0.5 120280.0 -10600.0 -0.4 -0.6362 -0.9934 3562071 PK04_181229 C[n+]1cc2ccccc2cc1C#N 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L14 compound treatment 23000.0 -103000.0 -4.0 30200.0 -101000.0 -3.78 -5.4993 -0.9996 3562072 PK04_181230 COc1ccc(CN/2C(C3CC3)c4ccccc4C\C2=N\P(=O)(Oc5ccccc5)Oc6ccccc6)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L15 mock treatment 113640.0 -12400.0 -0.48 129200.0 -1680.0 -0.06 -0.3852 -0.7927 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L16 mock treatment 113840.0 -12200.0 -0.47 115280.0 -15600.0 -0.59 -0.7491 -0.9945 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L17 compound treatment 43240.0 -82800.0 -3.21 70640.0 -60200.0 -2.26 -3.8708 -0.9852 3562074 PK04_181231 CCCCOC1CC2[N+](=C(C)C1c3ccccc23)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L18 compound treatment 63760.0 -62300.0 -2.42 80440.0 -50400.0 -1.89 -3.0477 -0.9927 3562075 PK04_181232 CCCCCCC1C[C@]2(CCC[C@@H](C)C2)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L19 compound treatment 4920.0 -121000.0 -4.7 6040.0 -125000.0 -4.69 -6.6366 -1.0 3188663 PK04_181233 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L20 compound treatment 42800.0 -83300.0 -3.23 70400.0 -60500.0 -2.27 -3.8892 -0.9851 3562077 PK04_181234 CC1(CCO)CC(C)(CCc2ccccc2)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L21 compound treatment 56880.0 -69200.0 -2.68 78720.0 -52200.0 -1.96 -3.2821 -0.988 3070955 PK04_181235 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L22 compound treatment 90440.0 -35600.0 -1.38 102280.0 -28600.0 -1.07 -1.7361 -0.9922 3562078 PK04_181236 COC(=O)CC1(C)CC(C)(CCc2ccccc2)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L23 mock treatment 112760.0 -13300.0 -0.52 121720.0 -9160.0 -0.34 -0.6078 -0.9805 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 L24 mock treatment 105040.0 -21000.0 -0.82 144280.0 13400.0 0.5 -0.2209 -0.2306 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M01 compound treatment 2920.0 -123000.0 -4.78 4440.0 -126000.0 -4.75 -6.7339 -1.0 3562079 PK04_181237 CC(C)(C)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C\COC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M02 compound treatment 5000.0 -121000.0 -4.7 7680.0 -123000.0 -4.62 -6.5908 -1.0 3562081 PK04_181238 Clc1ccccc1/C=C/C=C\2/C(=O)N(CS2(=O)=O)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M03 compound treatment 18600.0 -107000.0 -4.17 54560.0 -76300.0 -2.86 -4.9736 -0.9832 3562049 PK04_181239 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M04 compound treatment 3000.0 -123000.0 -4.77 5240.0 -126000.0 -4.72 -6.7105 -1.0 3562083 PK04_181240 CN1C(c2ccccc2)S(=O)(=O)/C(=C\C=C\c3ccccc3Cl)/C1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M05 compound treatment 8480.0 -118000.0 -4.56 9960.0 -121000.0 -4.54 -6.4349 -1.0 3562085 PK04_181241 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M06 compound treatment 113880.0 -12200.0 -0.47 127640.0 -3240.0 -0.12 -0.42 -0.8609 1053847 PK04_181242 O=C1CSC(N1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M07 compound treatment 87040.0 -39000.0 -1.51 130400.0 -477.0 -0.02 -1.0831 -0.7154 3562085 PK04_181243 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M08 compound treatment 57640.0 -68400.0 -2.65 94720.0 -36200.0 -1.36 -2.8367 -0.9515 3562087 PK04_181244 COc1ccccc1/C=C/C=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M09 mock treatment 109080.0 -17000.0 -0.66 122280.0 -8600.0 -0.32 -0.694 -0.9461 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M10 mock treatment 104440.0 -21600.0 -0.84 120640.0 -10200.0 -0.38 -0.8648 -0.9373 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M11 compound treatment 14760.0 -111000.0 -4.32 28160.0 -103000.0 -3.86 -5.7796 -0.9984 3562085 PK04_181245 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M12 compound treatment 116720.0 -9340.0 -0.36 116080.0 -14800.0 -0.56 -0.6489 -0.9786 3562088 PK04_181246 O=C1CS(=O)(=O)C(N1c2ccccc2)c3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M13 mock treatment 120960.0 -5100.0 -0.2 118880.0 -12000.0 -0.45 -0.4582 -0.9318 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M14 mock treatment 114800.0 -11300.0 -0.44 122280.0 -8600.0 -0.32 -0.537 -0.9889 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M15 compound treatment 7400.0 -119000.0 -4.6 25080.0 -106000.0 -3.97 -6.0632 -0.9973 3562089 PK04_181247 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M16 compound treatment 13200.0 -113000.0 -4.38 27360.0 -104000.0 -3.89 -5.8436 -0.9982 2118235 PK04_181248 [O-][N+](=O)c1cccc(/C=C/C=O)c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M17 compound treatment 18680.0 -107000.0 -4.17 52600.0 -78300.0 -2.94 -5.0234 -0.9854 3562089 PK04_181249 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M18 compound treatment 4160.0 -122000.0 -4.73 11080.0 -120000.0 -4.5 -6.5237 -0.9997 3562090 PK04_181250 CC(C)Cc1ccc(/C=C/C=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M19 compound treatment 8760.0 -117000.0 -4.55 46680.0 -84200.0 -3.16 -5.4527 -0.9841 3561852 PK04_181251 CCOC(=O)C1C2OC3(C=C2)C(N(C(=O)C13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M20 compound treatment 4960.0 -121000.0 -4.7 11680.0 -119000.0 -4.47 -6.4858 -0.9997 3215597 PK04_181252 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4cc(C)cc(C)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M21 compound treatment 4080.0 -122000.0 -4.73 6520.0 -124000.0 -4.67 -6.6469 -1.0 3562092 PK04_181253 O=C1C2C3C(OC42C=CCN(Cc5ccccc5)C(=O)C4N1C6CCCCC6)C=CCOC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M22 compound treatment 90480.0 -35600.0 -1.38 121400.0 -9480.0 -0.36 -1.2276 -0.8612 3562093 PK04_181254 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M23 compound treatment 8000.0 -118000.0 -4.58 16360.0 -115000.0 -4.3 -6.2782 -0.9995 3562094 PK04_181255 O=C1C2C3C4OC2(C=C4)C(N1C5CCCCC5)C(=O)N(Cc6ccccc6)CCCCOC3=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 M24 compound treatment 88920.0 -37100.0 -1.44 142920.0 12000.0 0.45 -0.6993 -0.4631 3562095 PK04_181256 Cc1cc(C)cc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N01 compound treatment 39440.0 -86600.0 -3.36 63760.0 -67100.0 -2.52 -4.1576 -0.9899 3188533 PK04_181257 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N02 compound treatment 83720.0 -42300.0 -1.64 152840.0 22000.0 0.82 -0.5787 -0.3149 3562096 PK04_181258 CC1(CCc2ccccc2)CC(C)(CC(=O)O)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N03 compound treatment 3320.0 -123000.0 -4.76 7120.0 -124000.0 -4.64 -6.6518 -0.9999 3562097 PK04_181259 C=C/C=C/[C@H]1[C@@H]2[C@H](Cc3ccccc3)OC(=O)[C@H](Cc4ccccc4)N2CC1=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N04 compound treatment 4520.0 -122000.0 -4.72 54640.0 -76200.0 -2.86 -5.3577 -0.9713 3562099 PK04_181260 CC1(CCOCc2ccccc2)CC(C)(COCc3ccccc3)OO1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N05 compound treatment 64720.0 -61300.0 -2.38 108120.0 -22800.0 -0.85 -2.2868 -0.9044 3562100 PK04_181261 Cn1c(=O)n2[C@H]3[C@@H]4[C@H](Cc5ccccc5)OC(=O)[C@H](Cc6ccccc6)N4CC3=C[C@@H](C7CC7)n2c1=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N06 compound treatment 68840.0 -57200.0 -2.22 86640.0 -44200.0 -1.66 -2.7438 -0.9898 3562102 PK04_181262 C[C@@H]1CCC[C@]2(CC(C)(CCOCc3ccccc3)OO2)C1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N07 compound treatment 5960.0 -120000.0 -4.66 30560.0 -100000.0 -3.77 -5.9573 -0.9944 3562104 PK04_181263 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3[C@H]1Cc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N08 compound treatment 114080.0 -12000.0 -0.46 121320.0 -9560.0 -0.36 -0.5822 -0.9918 3562106 PK04_181264 CC1(C)O[C@]2(C)CC[C@@H]1OO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N09 mock treatment 106200.0 -19900.0 -0.77 126080.0 -4800.0 -0.18 -0.6721 -0.8494 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N10 mock treatment 120040.0 -6020.0 -0.23 121960.0 -8920.0 -0.33 -0.4017 -0.9845 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N11 compound treatment 79520.0 -46500.0 -1.81 99480.0 -31400.0 -1.18 -2.11 -0.9786 3188666 PK04_181265 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N12 compound treatment 109880.0 -16200.0 -0.63 123600.0 -7280.0 -0.27 -0.637 -0.9305 3562108 PK04_181266 CC[C@]1(CC[C@@H]2OO1)OC2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N13 mock treatment 112000.0 -14100.0 -0.55 113680.0 -17200.0 -0.65 -0.8421 -0.9965 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N14 mock treatment 121720.0 -4340.0 -0.17 109320.0 -21600.0 -0.81 -0.6911 -0.8363 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N15 compound treatment 62080.0 -64000.0 -2.48 82760.0 -48100.0 -1.81 -3.0323 -0.9878 3188536 PK04_181267 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N16 compound treatment 96520.0 -29500.0 -1.15 119080.0 -11800.0 -0.44 -1.1235 -0.9144 3562110 PK04_181268 CCC[C@]1(CC[C@@H]2OO1)OC2(C)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N17 compound treatment 18400.0 -108000.0 -4.18 95400.0 -35500.0 -1.33 -3.8952 -0.8885 3188535 PK04_181269 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N18 compound treatment 55920.0 -70100.0 -2.72 89720.0 -41200.0 -1.54 -3.0166 -0.964 3562112 PK04_181270 CC1(C)O[C@]2(CCc3ccccc3)CC[C@@H]1OO2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N19 compound treatment 4480.0 -122000.0 -4.72 15400.0 -115000.0 -4.33 -6.4002 -0.9991 3070940 PK04_181271 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N20 compound treatment 63200.0 -62900.0 -2.44 75560.0 -55300.0 -2.08 -3.1926 -0.9968 3562114 PK04_181272 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N21 compound treatment 4520.0 -122000.0 -4.72 8040.0 -123000.0 -4.61 -6.5945 -0.9999 3188534 PK04_181273 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N22 compound treatment 34400.0 -91700.0 -3.56 75240.0 -55600.0 -2.09 -3.9913 -0.9678 3562115 PK04_181274 CC(C)(C)[C@H]1CC[C@]2(CC(C[Si](C)(C)C)OO2)CC1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N23 compound treatment 27360.0 -98700.0 -3.83 69800.0 -61100.0 -2.29 -4.3288 -0.9699 3562117 PK04_181275 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@H](C4CC4)n5n([C@@H]3[C@H]2[C@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 N24 compound treatment 138240.0 12200.0 0.47 152400.0 21500.0 0.81 0.9054 0.9674 1004341 PK04_181276 c1ccc2cnccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O01 compound treatment 70760.0 -55300.0 -2.15 111800.0 -19100.0 -0.72 -2.0234 -0.8946 3562118 PK04_181277 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)c4cccc(Cl)c4CO)C(=O)NCc5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O02 compound treatment 5200.0 -121000.0 -4.69 11760.0 -119000.0 -4.47 -6.4771 -0.9997 3562120 PK04_181278 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O03 compound treatment 34840.0 -91200.0 -3.54 97000.0 -33900.0 -1.27 -3.4017 -0.9045 3562122 PK04_181279 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O04 compound treatment 7480.0 -119000.0 -4.6 11520.0 -119000.0 -4.48 -6.4209 -0.9999 3562124 PK04_181280 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O05 compound treatment 79400.0 -46700.0 -1.81 108520.0 -22400.0 -0.84 -1.8734 -0.9389 3562122 PK04_181281 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O06 compound treatment 5400.0 -121000.0 -4.68 9040.0 -122000.0 -4.57 -6.5438 -0.9999 3562126 PK04_181282 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4cc(C)cc(C)c4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O07 compound treatment 3960.0 -122000.0 -4.74 10720.0 -120000.0 -4.51 -6.5387 -0.9997 3562128 PK04_181283 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O08 compound treatment 7920.0 -118000.0 -4.58 13240.0 -118000.0 -4.42 -6.3632 -0.9998 3215600 PK04_181284 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O09 compound treatment 90160.0 -35900.0 -1.39 136360.0 5480.0 0.21 -0.8394 -0.5962 3562128 PK04_181285 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O10 compound treatment 101520.0 -24500.0 -0.95 122160.0 -8720.0 -0.33 -0.9046 -0.8985 3562130 PK04_181286 OCCSCC(O)CC(O)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O11 mock treatment 104240.0 -21800.0 -0.85 122960.0 -7920.0 -0.3 -0.8087 -0.9014 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O12 mock treatment 116120.0 -9940.0 -0.39 115720.0 -15200.0 -0.57 -0.6749 -0.9821 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O13 compound treatment 97520.0 -28500.0 -1.11 101800.0 -29100.0 -1.09 -1.5546 -1.0 3561848 PK04_181287 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O14 compound treatment 109840.0 -16200.0 -0.63 116480.0 -14400.0 -0.54 -0.827 -0.9971 3562131 PK04_181288 OC(CSc1ccncc1)CC(O)c2ccccc2 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O15 compound treatment 90840.0 -35200.0 -1.37 126320.0 -4560.0 -0.17 -1.0872 -0.7894 3562132 PK04_181289 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O16 compound treatment 100880.0 -25200.0 -0.98 115840.0 -15000.0 -0.56 -1.0898 -0.966 3562134 PK04_181290 COC(=O)CCCCCCC(=O)Nc1ccc(C=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O17 compound treatment 89960.0 -36100.0 -1.4 117760.0 -13100.0 -0.49 -1.3385 -0.9016 3562132 PK04_181291 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O18 compound treatment 62720.0 -63300.0 -2.46 96040.0 -34800.0 -1.31 -2.6623 -0.9564 3562135 PK04_181292 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccccn3)CC(O2)c4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O19 compound treatment 47640.0 -78400.0 -3.04 86720.0 -44200.0 -1.66 -3.3233 -0.9592 3561921 PK04_181293 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O20 compound treatment 71400.0 -54700.0 -2.12 106120.0 -24800.0 -0.93 -2.1566 -0.9314 3562136 PK04_181294 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc4ccccc4s3)CC(O2)c5ccccc5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O21 compound treatment 64440.0 -61600.0 -2.39 107240.0 -23600.0 -0.89 -2.3178 -0.9089 3561921 PK04_181295 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O22 compound treatment 93960.0 -32100.0 -1.25 126000.0 -4880.0 -0.18 -1.0101 -0.8024 3562137 PK04_181296 OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O23 compound treatment 74800.0 -51300.0 -1.99 115320.0 -15600.0 -0.58 -1.8192 -0.8777 3561921 PK04_181297 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 O24 compound treatment 89840.0 -36200.0 -1.41 107960.0 -22900.0 -0.86 -1.6019 -0.9722 3562138 PK04_181298 CC(C)(C)OC(=O)OC(CC=C)c1ccccc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P01 compound treatment 3400.0 -123000.0 -4.76 3880.0 -127000.0 -4.77 -6.7356 -1.0 3562139 PK04_181299 COC(=O)C1(CCCCC1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P02 compound treatment 116240.0 -9820.0 -0.38 130280.0 -597.0 -0.02 -0.2852 -0.7474 1015751 PK04_181300 Cc1ccncc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P03 compound treatment 44240.0 -81800.0 -3.17 56840.0 -74000.0 -2.78 -4.2096 -0.9978 3562141 PK04_181301 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@H](/C=C/C3CC3)[C@@H](O)Cc4ccccc4)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P04 compound treatment 108480.0 -17600.0 -0.68 143080.0 12200.0 0.46 -0.1584 -0.1928 3562143 PK04_181302 COc1cc2CCN(=Cc2cc1OC)Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P05 compound treatment 19640.0 -106000.0 -4.13 51960.0 -78900.0 -2.96 -5.014 -0.9867 3562144 PK04_181303 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=CCCC=C[C@H]4[C@@H]3[C@@H](O)Cc5ccccc5)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P06 compound treatment 91400.0 -34700.0 -1.34 131400.0 523.0 0.02 -0.937 -0.6967 1024512 PK04_181304 COc1cc2CCN=C(C)c2cc1OC 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P07 compound treatment 4760.0 -121000.0 -4.71 6400.0 -124000.0 -4.67 -6.6314 -1.0 3562146 PK04_181305 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3C51CCCCC5 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P08 compound treatment 113320.0 -12700.0 -0.49 123840.0 -7040.0 -0.26 -0.5362 -0.9569 3562148 PK04_181306 COc1cc2CC(C)N(=Cc2cc1OC)Cl 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P09 compound treatment 74640.0 -51400.0 -2.0 95240.0 -35600.0 -1.34 -2.3565 -0.9811 3562149 PK04_181307 COC(=O)C1(CCCC1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P10 compound treatment 93480.0 -32600.0 -1.26 133800.0 2920.0 0.11 -0.8162 -0.6433 1003512 PK04_181308 C[n+]1ccc2ccccc2c1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P11 mock treatment 116520.0 -9540.0 -0.37 139640.0 8760.0 0.33 -0.0291 -0.0588 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P12 mock treatment 127360.0 1300.0 0.05 138880.0 8000.0 0.3 0.2481 0.8146 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P13 compound treatment 57880.0 -68200.0 -2.65 79280.0 -51600.0 -1.94 -3.2398 -0.9882 3562151 PK04_181309 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3C[C@](C)(OC)O[C@@H](Cc4ccccc4)[C@H]3/C=C/C5CC5)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P14 compound treatment 110000.0 -16100.0 -0.62 135200.0 4320.0 0.16 -0.3258 -0.5061 1009497 PK04_181310 Cc1cc[n+](C)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P15 compound treatment 28560.0 -97500.0 -3.78 75720.0 -55200.0 -2.07 -4.1387 -0.9598 3562153 PK04_181311 COC(=O)[C@@H]1N[C@H](SC1(C)C)[C@@H]2N(CC#C)[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P16 compound treatment 98120.0 -27900.0 -1.08 119480.0 -11400.0 -0.43 -1.069 -0.9173 1023898 PK04_181312 COc1cc2CC[N+](=Cc2cc1OC)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P17 compound treatment 5440.0 -121000.0 -4.68 21800.0 -109000.0 -4.09 -6.204 -0.9978 3562155 PK04_181313 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC(=C[C@@H]3[C@@H](O)Cc4ccccc4)/C=C/C5CC5)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P18 compound treatment 98800.0 -27300.0 -1.06 112720.0 -18200.0 -0.68 -1.2297 -0.9774 1071838 PK04_181314 COc1cc2CC[N+](=C(C)c2cc1OC)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P19 compound treatment 82000.0 -44100.0 -1.71 118320.0 -12600.0 -0.47 -1.542 -0.8696 3562157 PK04_181315 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)C41CCCC4 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P20 compound treatment 93680.0 -32400.0 -1.26 116840.0 -14000.0 -0.53 -1.2608 -0.9255 1023900 PK04_181316 COc1cc2CC(C)[N+](=Cc2cc1OC)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P21 compound treatment 47480.0 -78600.0 -3.05 77080.0 -53800.0 -2.02 -3.5836 -0.98 3562159 PK04_181317 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=C[C@@H](C5CC5)n6n(C4[C@@H]3[C@@H](O)Cc7ccccc7)c(=O)n(C)c6=O)C2=O 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P22 compound treatment 99040.0 -27000.0 -1.05 102320.0 -28600.0 -1.07 -1.4991 -0.9999 1107245 PK04_181318 COc1ccc(C[n+]2ccc3ccccc3c2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P23 compound treatment 7800.0 -118000.0 -4.59 17880.0 -113000.0 -4.24 -6.2433 -0.9992 3562161 PK04_181319 CC(=CCc1cc(/C=C/2\OC(=O)C(=C2O)c3cc4CCC(C)(C)Oc4cc3O)ccc1O)C 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.2181 P24 compound treatment 105040.0 -21000.0 -0.82 115600.0 -15300.0 -0.57 -0.9821 -0.9851 3562163 PK04_181320 COc1ccc(C[n+]2ccc(C)cc2)cc1 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A01 mock treatment 149160.0 40400.0 1.57 98320.0 3800.0 0.14 1.2083 0.7683 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A02 mock treatment 150560.0 41800.0 1.62 95840.0 1320.0 0.05 1.1809 0.7284 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A03 mock treatment 147360.0 38600.0 1.5 99960.0 5440.0 0.2 1.2024 0.7962 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A04 mock treatment 161280.0 52500.0 2.04 103960.0 9440.0 0.35 1.6905 0.8178 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A05 mock treatment 163200.0 54400.0 2.11 101520.0 7000.0 0.26 1.6784 0.789 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A06 mock treatment 155960.0 47200.0 1.83 97320.0 2800.0 0.11 1.3683 0.7465 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A07 mock treatment 163400.0 54600.0 2.12 91520.0 -3000.0 -0.11 1.4185 0.6686 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A08 mock treatment 164720.0 55900.0 2.17 101600.0 7080.0 0.27 1.7222 0.7878 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A09 mock treatment 170760.0 62000.0 2.4 87280.0 -7240.0 -0.27 1.5079 0.6232 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A10 mock treatment 165760.0 57000.0 2.21 97560.0 3040.0 0.11 1.6436 0.7426 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A11 mock treatment 150600.0 41800.0 1.62 102840.0 8320.0 0.31 1.3678 0.828 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A12 mock treatment 149000.0 40200.0 1.56 94240.0 -281.0 -0.01 1.0956 0.7023 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A13 mock treatment 158840.0 50000.0 1.94 92120.0 -2400.0 -0.09 1.3093 0.6736 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A14 mock treatment 145600.0 36800.0 1.43 86520.0 -8000.0 -0.3 0.7975 0.5465 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A15 mock treatment 146840.0 38000.0 1.48 92040.0 -2480.0 -0.09 0.978 0.6612 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A16 mock treatment 155720.0 46900.0 1.82 97080.0 2560.0 0.1 1.3554 0.7434 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A17 mock treatment 166400.0 57600.0 2.24 92280.0 -2240.0 -0.08 1.521 0.68 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A18 mock treatment 156160.0 47400.0 1.84 98520.0 4000.0 0.15 1.4056 0.7623 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A19 mock treatment 164480.0 55700.0 2.16 97240.0 2720.0 0.1 1.5999 0.7397 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A20 mock treatment 158520.0 49700.0 1.93 96480.0 1960.0 0.07 1.4163 0.7335 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A21 mock treatment 158760.0 50000.0 1.94 90200.0 -4320.0 -0.16 1.2562 0.6457 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A22 mock treatment 169160.0 60400.0 2.34 100600.0 6080.0 0.23 1.8175 0.7723 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A23 mock treatment 158000.0 49200.0 1.91 102360.0 7840.0 0.29 1.558 0.8065 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base A24 mock treatment 152840.0 44000.0 1.71 104200.0 9680.0 0.36 1.4653 0.8387 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B01 mock treatment 154320.0 45500.0 1.77 104600.0 10100.0 0.38 1.5165 0.8395 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B02 mock treatment 130440.0 21600.0 0.84 107200.0 12700.0 0.48 0.9304 0.9638 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B03 mock treatment 135800.0 27000.0 1.05 108400.0 13900.0 0.52 1.1093 0.9479 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B04 mock treatment 117960.0 9170.0 0.36 104960.0 10400.0 0.39 0.5285 0.9988 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B05 mock treatment 116480.0 7690.0 0.3 102000.0 7480.0 0.28 0.4093 0.9995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B06 mock treatment 117720.0 8930.0 0.35 114520.0 20000.0 0.75 0.7756 0.9383 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B07 mock treatment 121640.0 12800.0 0.5 97000.0 2480.0 0.09 0.4182 0.8248 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B08 mock treatment 142720.0 33900.0 1.32 109440.0 14900.0 0.56 1.3267 0.9275 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B09 mock treatment 121560.0 12800.0 0.5 105480.0 11000.0 0.41 0.6411 0.9957 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B10 mock treatment 116240.0 7450.0 0.29 97040.0 2520.0 0.09 0.2711 0.8919 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B11 mock treatment 138680.0 29900.0 1.16 99680.0 5160.0 0.19 0.9569 0.8139 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B12 mock treatment 123480.0 14700.0 0.57 91520.0 -3000.0 -0.11 0.3233 0.5565 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B13 mock treatment 132360.0 23600.0 0.91 100680.0 6160.0 0.23 0.81 0.8588 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B14 mock treatment 133840.0 25000.0 0.97 104560.0 10000.0 0.38 0.9536 0.9149 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B15 mock treatment 137720.0 28900.0 1.12 95200.0 679.0 0.03 0.8116 0.723 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B16 mock treatment 151080.0 42300.0 1.64 103160.0 8640.0 0.32 1.3894 0.8308 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B17 mock treatment 162000.0 53200.0 2.06 97920.0 3400.0 0.13 1.55 0.7494 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B18 mock treatment 154120.0 45300.0 1.76 97800.0 3280.0 0.12 1.3306 0.7547 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B19 mock treatment 171040.0 62200.0 2.42 102360.0 7840.0 0.29 1.9158 0.7874 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B20 mock treatment 168800.0 60000.0 2.33 103720.0 9200.0 0.35 1.8904 0.8032 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B21 mock treatment 172560.0 63800.0 2.47 99080.0 4560.0 0.17 1.8705 0.7542 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B22 mock treatment 162960.0 54200.0 2.1 95200.0 679.0 0.03 1.5041 0.7156 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B23 mock treatment 170880.0 62100.0 2.41 102000.0 7480.0 0.28 1.9019 0.7842 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base B24 mock treatment 158800.0 50000.0 1.94 99520.0 5000.0 0.19 1.5046 0.7719 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C01 mock treatment 126720.0 17900.0 0.7 96800.0 2280.0 0.09 0.5523 0.7881 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C02 mock treatment 117360.0 8570.0 0.33 105640.0 11100.0 0.42 0.5301 0.9936 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C03 mock treatment 119720.0 10900.0 0.42 97600.0 3080.0 0.12 0.3815 0.8682 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C04 mock treatment 114160.0 5370.0 0.21 99880.0 5360.0 0.2 0.2894 0.9998 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C05 mock treatment 132560.0 23800.0 0.92 100520.0 6000.0 0.23 0.8112 0.8546 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C06 mock treatment 120240.0 11400.0 0.44 96720.0 2200.0 0.08 0.3724 0.8244 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C07 mock treatment 112280.0 3490.0 0.14 91600.0 -2920.0 -0.11 0.0181 0.104 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C08 mock treatment 117240.0 8450.0 0.33 99480.0 4960.0 0.19 0.3633 0.9641 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C09 mock treatment 114880.0 6090.0 0.24 99480.0 4960.0 0.19 0.2986 0.9931 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C10 mock treatment 110840.0 2050.0 0.08 88640.0 -5880.0 -0.22 -0.1 -0.4261 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C11 mock treatment 111880.0 3090.0 0.12 110440.0 15900.0 0.6 0.5071 0.8323 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C12 mock treatment 111640.0 2850.0 0.11 95600.0 1080.0 0.04 0.1067 0.9073 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C13 mock treatment 117000.0 8210.0 0.32 98200.0 3680.0 0.14 0.3228 0.93 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C14 mock treatment 116040.0 7250.0 0.28 94160.0 -361.0 -0.01 0.1892 0.6722 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C15 mock treatment 115400.0 6610.0 0.26 95120.0 599.0 0.02 0.1971 0.7661 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C16 mock treatment 114720.0 5930.0 0.23 93400.0 -1120.0 -0.04 0.1328 0.5682 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C17 mock treatment 127880.0 19100.0 0.74 98160.0 3640.0 0.14 0.6202 0.8236 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C18 mock treatment 116920.0 8130.0 0.32 95160.0 639.0 0.02 0.2399 0.7587 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C19 mock treatment 112600.0 3810.0 0.15 92960.0 -1560.0 -0.06 0.063 0.3964 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C20 mock treatment 139400.0 30600.0 1.19 109280.0 14800.0 0.55 1.2314 0.9397 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C21 mock treatment 127440.0 18600.0 0.72 88720.0 -5800.0 -0.22 0.3576 0.4733 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C22 mock treatment 126680.0 17900.0 0.69 94000.0 -521.0 -0.02 0.4769 0.6869 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C23 mock treatment 159280.0 50500.0 1.96 89320.0 -5200.0 -0.2 1.2471 0.6335 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base C24 mock treatment 155040.0 46200.0 1.79 107880.0 13400.0 0.5 1.6233 0.8713 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D01 mock treatment 107840.0 -954.0 -0.04 114320.0 19800.0 0.74 0.4993 0.6711 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D02 mock treatment 118640.0 9850.0 0.38 113920.0 19400.0 0.73 0.785 0.9547 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D03 mock treatment 123280.0 14500.0 0.56 112120.0 17600.0 0.66 0.8645 0.9968 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D04 mock treatment 125560.0 16800.0 0.65 104280.0 9760.0 0.37 0.719 0.9631 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D05 mock treatment 121320.0 12500.0 0.49 106720.0 12200.0 0.46 0.6674 0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D06 mock treatment 114840.0 6050.0 0.23 105400.0 10900.0 0.41 0.4546 0.9654 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D07 mock treatment 119840.0 11000.0 0.43 89120.0 -5400.0 -0.2 0.1597 0.3369 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D08 mock treatment 128600.0 19800.0 0.77 93280.0 -1240.0 -0.05 0.5105 0.663 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D09 mock treatment 110680.0 1890.0 0.07 104560.0 10000.0 0.38 0.3182 0.829 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D10 mock treatment 123760.0 15000.0 0.58 118240.0 23700.0 0.89 1.0401 0.9786 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D11 mock treatment 113560.0 4770.0 0.18 99480.0 4960.0 0.19 0.2624 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D12 mock treatment 118360.0 9570.0 0.37 104760.0 10200.0 0.38 0.5342 0.9998 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D13 mock treatment 118680.0 9890.0 0.38 96360.0 1840.0 0.07 0.32 0.8211 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D14 mock treatment 117760.0 8970.0 0.35 101680.0 7160.0 0.27 0.436 0.9918 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D15 mock treatment 117280.0 8490.0 0.33 98000.0 3480.0 0.13 0.3251 0.918 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D16 mock treatment 110120.0 1330.0 0.05 97120.0 2600.0 0.1 0.1053 0.9554 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D17 mock treatment 114400.0 5610.0 0.22 101520.0 7000.0 0.26 0.3395 0.9956 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D18 mock treatment 114320.0 5530.0 0.21 94360.0 -161.0 -0.01 0.1473 0.6868 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D19 mock treatment 113280.0 4490.0 0.17 100360.0 5840.0 0.22 0.278 0.9935 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D20 mock treatment 124560.0 15800.0 0.61 92720.0 -1800.0 -0.07 0.3847 0.6251 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D21 mock treatment 112160.0 3370.0 0.13 99240.0 4720.0 0.18 0.2176 0.9888 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D22 mock treatment 117800.0 9010.0 0.35 106360.0 11800.0 0.44 0.5613 0.9929 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D23 mock treatment 116800.0 8010.0 0.31 93360.0 -1160.0 -0.04 0.1888 0.602 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base D24 mock treatment 123640.0 14800.0 0.58 100760.0 6240.0 0.23 0.5729 0.9213 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E01 mock treatment 112040.0 3250.0 0.13 99160.0 4640.0 0.17 0.2122 0.9874 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E02 mock treatment 118000.0 9210.0 0.36 107880.0 13400.0 0.5 0.6071 0.9862 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E03 mock treatment 113520.0 4730.0 0.18 104600.0 10100.0 0.38 0.3971 0.9447 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E04 mock treatment 108480.0 -314.0 -0.01 102480.0 7960.0 0.3 0.2026 0.6777 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E05 mock treatment 112680.0 3890.0 0.15 96960.0 2440.0 0.09 0.1713 0.9714 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E06 mock treatment 109080.0 286.0 0.01 104600.0 10100.0 0.38 0.2753 0.7275 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E07 mock treatment 118120.0 9330.0 0.36 91920.0 -2600.0 -0.1 0.1868 0.4985 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E08 mock treatment 112040.0 3250.0 0.13 100640.0 6120.0 0.23 0.2514 0.96 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E09 mock treatment 108200.0 -594.0 -0.02 100520.0 6000.0 0.23 0.1429 0.6314 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E10 mock treatment 109040.0 246.0 0.01 101760.0 7240.0 0.27 0.1989 0.7315 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E11 mock treatment 114440.0 5650.0 0.22 100040.0 5520.0 0.21 0.3014 0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E12 mock treatment 116120.0 7330.0 0.28 94440.0 -81.5 0.0 0.1988 0.6995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E13 mock treatment 112200.0 3410.0 0.13 98960.0 4440.0 0.17 0.2112 0.9934 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E14 mock treatment 110880.0 2090.0 0.08 92600.0 -1920.0 -0.07 0.0062 0.0576 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E15 mock treatment 106840.0 -1950.0 -0.08 97720.0 3200.0 0.12 0.0313 0.2203 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E16 mock treatment 118880.0 10100.0 0.39 97720.0 3200.0 0.12 0.3616 0.8834 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E17 mock treatment 105200.0 -3590.0 -0.14 99080.0 4560.0 0.17 0.0224 0.1014 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E18 mock treatment 106760.0 -2030.0 -0.08 91120.0 -3400.0 -0.13 -0.1461 -0.9733 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E19 mock treatment 109680.0 886.0 0.03 97960.0 3440.0 0.13 0.1156 0.8653 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E20 mock treatment 113600.0 4810.0 0.19 101840.0 7320.0 0.27 0.3261 0.9822 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E21 mock treatment 112960.0 4170.0 0.16 100400.0 5880.0 0.22 0.2703 0.9883 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E22 mock treatment 112640.0 3850.0 0.15 101920.0 7400.0 0.28 0.3019 0.9576 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E23 mock treatment 122160.0 13400.0 0.52 99520.0 5000.0 0.19 0.4994 0.9055 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base E24 mock treatment 111040.0 2250.0 0.09 102560.0 8040.0 0.3 0.275 0.8756 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F01 mock treatment 114920.0 6130.0 0.24 100480.0 5960.0 0.22 0.3262 0.9995 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F02 mock treatment 125640.0 16800.0 0.65 112080.0 17600.0 0.66 0.9282 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F03 mock treatment 109280.0 486.0 0.02 99000.0 4480.0 0.17 0.1322 0.7815 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F04 mock treatment 116560.0 7770.0 0.3 103560.0 9040.0 0.34 0.4529 0.9983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F05 mock treatment 109080.0 286.0 0.01 92080.0 -2440.0 -0.09 -0.0569 -0.6169 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F06 mock treatment 120880.0 12100.0 0.47 104040.0 9520.0 0.36 0.5842 0.991 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F07 mock treatment 104600.0 -4190.0 -0.16 90160.0 -4360.0 -0.16 -0.2308 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F08 mock treatment 104560.0 -4230.0 -0.16 100440.0 5920.0 0.22 0.0409 0.1481 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F09 mock treatment 119240.0 10400.0 0.41 102200.0 7680.0 0.29 0.4904 0.986 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F10 mock treatment 110560.0 1770.0 0.07 100680.0 6160.0 0.23 0.2119 0.8789 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F11 mock treatment 107720.0 -1070.0 -0.04 94040.0 -481.0 -0.02 -0.0422 -0.9301 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F12 mock treatment 108440.0 -354.0 -0.01 90480.0 -4040.0 -0.15 -0.117 -0.768 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F13 mock treatment 118400.0 9610.0 0.37 91480.0 -3040.0 -0.11 0.1828 0.469 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F14 mock treatment 111880.0 3090.0 0.12 93160.0 -1360.0 -0.05 0.0485 0.3728 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F15 mock treatment 104520.0 -4270.0 -0.17 94840.0 319.0 0.01 -0.1088 -0.6544 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F16 mock treatment 104920.0 -3870.0 -0.15 94440.0 -81.5 0.0 -0.1084 -0.7213 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F17 mock treatment 115360.0 6570.0 0.25 94880.0 359.0 0.01 0.1897 0.7434 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F18 mock treatment 110120.0 1330.0 0.05 88080.0 -6440.0 -0.24 -0.1346 -0.5444 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F19 mock treatment 114840.0 6050.0 0.23 100680.0 6160.0 0.23 0.3293 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F20 mock treatment 104280.0 -4510.0 -0.18 93520.0 -1000.0 -0.04 -0.1504 -0.8397 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F21 mock treatment 105840.0 -2950.0 -0.11 95920.0 1400.0 0.05 -0.0439 -0.3485 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F22 mock treatment 106960.0 -1830.0 -0.07 105000.0 10500.0 0.39 0.2278 0.5699 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F23 mock treatment 118520.0 9730.0 0.38 96760.0 2240.0 0.08 0.3263 0.8439 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base F24 mock treatment 107920.0 -874.0 -0.03 108040.0 13500.0 0.51 0.3348 0.6584 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G01 mock treatment 102440.0 -6350.0 -0.25 94120.0 -401.0 -0.02 -0.185 -0.7489 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G02 mock treatment 101680.0 -7110.0 -0.28 92680.0 -1840.0 -0.07 -0.244 -0.8577 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G03 mock treatment 117520.0 8730.0 0.34 93160.0 -1360.0 -0.05 0.2033 0.5937 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G04 mock treatment 97800.0 -11000.0 -0.43 102440.0 7920.0 0.3 -0.0915 -0.176 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G05 mock treatment 99480.0 -9310.0 -0.36 92160.0 -2360.0 -0.09 -0.3182 -0.8552 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G06 mock treatment 99440.0 -9350.0 -0.36 108000.0 13500.0 0.51 0.1011 0.1623 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G07 mock treatment 108560.0 -234.0 -0.01 84680.0 -9840.0 -0.37 -0.2676 -0.7243 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G08 mock treatment 111160.0 2370.0 0.09 89760.0 -4760.0 -0.18 -0.0614 -0.3059 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G09 mock treatment 101280.0 -7510.0 -0.29 92160.0 -2360.0 -0.09 -0.2688 -0.8822 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G10 mock treatment 104240.0 -4550.0 -0.18 88880.0 -5640.0 -0.21 -0.2747 -0.996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G11 mock treatment 106640.0 -2150.0 -0.08 88240.0 -6280.0 -0.24 -0.2258 -0.9027 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G12 mock treatment 110880.0 2090.0 0.08 86840.0 -7680.0 -0.29 -0.1466 -0.4897 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G13 mock treatment 107880.0 -914.0 -0.04 85080.0 -9440.0 -0.35 -0.2756 -0.774 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G14 mock treatment 106600.0 -2190.0 -0.09 86400.0 -8120.0 -0.3 -0.2757 -0.8712 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G15 mock treatment 102880.0 -5910.0 -0.23 85800.0 -8720.0 -0.33 -0.3937 -0.9849 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G16 mock treatment 111040.0 2250.0 0.09 85840.0 -8680.0 -0.33 -0.1688 -0.5004 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G17 mock treatment 100000.0 -8790.0 -0.34 79080.0 -15400.0 -0.58 -0.6511 -0.9681 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G18 mock treatment 101960.0 -6830.0 -0.27 79920.0 -14600.0 -0.55 -0.575 -0.9445 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G19 mock treatment 99280.0 -9510.0 -0.37 91680.0 -2840.0 -0.11 -0.3364 -0.8756 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G20 mock treatment 100200.0 -8590.0 -0.33 86920.0 -7600.0 -0.29 -0.4375 -0.997 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G21 mock treatment 120840.0 12000.0 0.47 107160.0 12600.0 0.47 0.6659 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G22 mock treatment 93680.0 -15100.0 -0.59 89280.0 -5240.0 -0.2 -0.5538 -0.8953 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G23 mock treatment 100120.0 -8670.0 -0.34 90480.0 -4040.0 -0.15 -0.3452 -0.9352 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base G24 mock treatment 109240.0 446.0 0.02 86680.0 -7840.0 -0.29 -0.1959 -0.6644 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H01 mock treatment 109080.0 286.0 0.01 102000.0 7480.0 0.28 0.2063 0.7345 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H02 mock treatment 117400.0 8610.0 0.33 105680.0 11200.0 0.42 0.5323 0.9937 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H03 mock treatment 115400.0 6610.0 0.26 95720.0 1200.0 0.04 0.2131 0.8187 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H04 mock treatment 100880.0 -7910.0 -0.31 92080.0 -2440.0 -0.09 -0.2819 -0.8798 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H05 mock treatment 120560.0 11800.0 0.46 90120.0 -4400.0 -0.17 0.206 0.4243 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H06 mock treatment 105400.0 -3390.0 -0.13 98040.0 3520.0 0.13 3.0E-4 0.0014 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H07 mock treatment 101080.0 -7710.0 -0.3 96440.0 1920.0 0.07 -0.1607 -0.5221 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H08 mock treatment 98560.0 -10200.0 -0.4 78960.0 -15600.0 -0.58 -0.6938 -0.9823 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H09 mock treatment 105760.0 -3030.0 -0.12 88320.0 -6200.0 -0.23 -0.2478 -0.9501 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H10 mock treatment 114080.0 5290.0 0.21 82200.0 -12300.0 -0.46 -0.182 -0.3597 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H11 mock treatment 103960.0 -4830.0 -0.19 85000.0 -9520.0 -0.36 -0.3853 -0.9547 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H12 mock treatment 102560.0 -6230.0 -0.24 92480.0 -2040.0 -0.08 -0.2252 -0.8876 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H13 mock treatment 105280.0 -3510.0 -0.14 85040.0 -9480.0 -0.36 -0.348 -0.9133 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H14 mock treatment 108520.0 -274.0 -0.01 85040.0 -9480.0 -0.36 -0.2591 -0.7279 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H15 mock treatment 110480.0 1690.0 0.07 91200.0 -3320.0 -0.12 -0.0419 -0.2975 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H16 mock treatment 104560.0 -4230.0 -0.16 88320.0 -6200.0 -0.23 -0.2807 -0.9855 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H17 mock treatment 97280.0 -11500.0 -0.45 81960.0 -12600.0 -0.47 -0.6493 -0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H18 mock treatment 110720.0 1930.0 0.07 89640.0 -4880.0 -0.18 -0.0767 -0.3877 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H19 mock treatment 97240.0 -11600.0 -0.45 95520.0 999.0 0.04 -0.2905 -0.6457 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H20 mock treatment 102760.0 -6030.0 -0.23 89400.0 -5120.0 -0.19 -0.3015 -0.9952 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H21 mock treatment 98040.0 -10800.0 -0.42 88360.0 -6160.0 -0.23 -0.4586 -0.9612 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H22 mock treatment 104080.0 -4710.0 -0.18 80800.0 -13700.0 -0.51 -0.4935 -0.903 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H23 mock treatment 97600.0 -11200.0 -0.43 111720.0 17200.0 0.65 0.1493 0.1919 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base H24 mock treatment 96920.0 -11900.0 -0.46 84080.0 -10400.0 -0.39 -0.6029 -0.9968 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I01 mock treatment 98600.0 -10200.0 -0.4 98760.0 4240.0 0.16 -0.1672 -0.3922 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I02 mock treatment 120040.0 11200.0 0.44 93160.0 -1360.0 -0.05 0.2724 0.6201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I03 mock treatment 99760.0 -9030.0 -0.35 91760.0 -2760.0 -0.1 -0.3211 -0.8786 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I04 mock treatment 105760.0 -3030.0 -0.12 105320.0 10800.0 0.41 0.2033 0.4818 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I05 mock treatment 103720.0 -5070.0 -0.2 91640.0 -2880.0 -0.11 -0.2157 -0.9602 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I06 mock treatment 100600.0 -8190.0 -0.32 87080.0 -7440.0 -0.28 -0.4223 -0.9979 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I07 mock treatment 100320.0 -8470.0 -0.33 79760.0 -14800.0 -0.55 -0.6242 -0.969 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I08 mock treatment 101280.0 -7510.0 -0.29 84080.0 -10400.0 -0.39 -0.4833 -0.9894 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I09 mock treatment 103920.0 -4870.0 -0.19 88920.0 -5600.0 -0.21 -0.2824 -0.9986 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I10 mock treatment 106240.0 -2550.0 -0.1 85240.0 -9280.0 -0.35 -0.3164 -0.8736 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I11 mock treatment 104400.0 -4390.0 -0.17 88760.0 -5760.0 -0.22 -0.2735 -0.9931 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I12 mock treatment 117200.0 8410.0 0.33 91080.0 -3440.0 -0.13 0.1393 0.3971 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I13 mock treatment 104080.0 -4710.0 -0.18 85160.0 -9360.0 -0.35 -0.3778 -0.9537 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I14 mock treatment 109480.0 686.0 0.03 81560.0 -13000.0 -0.49 -0.3252 -0.6674 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I15 mock treatment 99600.0 -9190.0 -0.36 84880.0 -9640.0 -0.36 -0.5081 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I16 mock treatment 101720.0 -7070.0 -0.27 83680.0 -10800.0 -0.41 -0.4818 -0.9816 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I17 mock treatment 109480.0 686.0 0.03 87440.0 -7080.0 -0.27 -0.1691 -0.6331 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I18 mock treatment 101440.0 -7350.0 -0.29 82000.0 -12500.0 -0.47 -0.5341 -0.9714 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I19 mock treatment 115080.0 6290.0 0.24 90400.0 -4120.0 -0.15 0.0631 0.2184 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I20 mock treatment 96680.0 -12100.0 -0.47 86560.0 -7960.0 -0.3 -0.5436 -0.9761 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I21 mock treatment 104360.0 -4430.0 -0.17 88760.0 -5760.0 -0.22 -0.2746 -0.9936 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I22 mock treatment 103280.0 -5510.0 -0.21 102040.0 7520.0 0.28 0.0483 0.1363 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I23 mock treatment 116840.0 8050.0 0.31 88840.0 -5680.0 -0.21 0.07 0.1851 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base I24 mock treatment 106760.0 -2030.0 -0.08 88120.0 -6400.0 -0.24 -0.2257 -0.8925 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J01 mock treatment 99520.0 -9270.0 -0.36 99880.0 5360.0 0.2 -0.1122 -0.2723 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J02 mock treatment 105280.0 -3510.0 -0.14 107800.0 13300.0 0.5 0.256 0.4955 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J03 mock treatment 110840.0 2050.0 0.08 87480.0 -7040.0 -0.26 -0.1307 -0.4738 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J04 mock treatment 121040.0 12200.0 0.48 89040.0 -5480.0 -0.21 0.1905 0.3679 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J05 mock treatment 106840.0 -1950.0 -0.08 94640.0 119.0 0.0 -0.0505 -0.6645 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J06 mock treatment 96880.0 -11900.0 -0.46 88480.0 -6040.0 -0.23 -0.4872 -0.9462 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J07 mock treatment 118840.0 10000.0 0.39 99400.0 4880.0 0.18 0.4051 0.9407 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J08 mock treatment 103600.0 -5190.0 -0.2 89640.0 -4880.0 -0.18 -0.272 -0.9989 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J09 mock treatment 116680.0 7890.0 0.31 86000.0 -8520.0 -0.32 -0.0098 -0.0221 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J10 mock treatment 102800.0 -5990.0 -0.23 91280.0 -3240.0 -0.12 -0.2505 -0.9543 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J11 mock treatment 104160.0 -4630.0 -0.18 87560.0 -6960.0 -0.26 -0.3119 -0.9834 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J12 mock treatment 105160.0 -3630.0 -0.14 88360.0 -6160.0 -0.23 -0.2632 -0.9718 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J13 mock treatment 106240.0 -2550.0 -0.1 87600.0 -6920.0 -0.26 -0.2538 -0.9127 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J14 mock treatment 104600.0 -4190.0 -0.16 86440.0 -8080.0 -0.3 -0.3295 -0.9574 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J15 mock treatment 98400.0 -10400.0 -0.4 102720.0 8200.0 0.31 -0.0676 -0.1332 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J16 mock treatment 108880.0 86.1 0.0 85120.0 -9400.0 -0.35 -0.2471 -0.7004 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J17 mock treatment 99120.0 -9670.0 -0.38 91720.0 -2800.0 -0.11 -0.3398 -0.8716 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J18 mock treatment 96560.0 -12200.0 -0.47 85240.0 -9280.0 -0.35 -0.582 -0.9884 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J19 mock treatment 108120.0 -674.0 -0.03 101320.0 6800.0 0.26 0.1619 0.6313 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J20 mock treatment 95480.0 -13300.0 -0.52 89800.0 -4720.0 -0.18 -0.4906 -0.8983 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J21 mock treatment 107040.0 -1750.0 -0.07 97320.0 2800.0 0.11 0.0262 0.2089 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J22 mock treatment 101560.0 -7230.0 -0.28 83160.0 -11400.0 -0.43 -0.5 -0.9794 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J23 mock treatment 98720.0 -10100.0 -0.39 92480.0 -2040.0 -0.08 -0.3306 -0.8299 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base J24 mock treatment 116400.0 7610.0 0.3 96160.0 1640.0 0.06 0.2522 0.8365 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K01 mock treatment 112440.0 3650.0 0.14 92360.0 -2160.0 -0.08 0.0427 0.2617 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K02 mock treatment 105920.0 -2870.0 -0.11 92640.0 -1880.0 -0.07 -0.1288 -0.9757 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K03 mock treatment 96640.0 -12200.0 -0.47 93160.0 -1360.0 -0.05 -0.3696 -0.7792 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K04 mock treatment 101960.0 -6830.0 -0.27 98080.0 3560.0 0.13 -0.0931 -0.3134 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K05 mock treatment 99040.0 -9750.0 -0.38 86320.0 -8200.0 -0.31 -0.4853 -0.9947 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K06 mock treatment 93680.0 -15100.0 -0.59 83000.0 -11500.0 -0.43 -0.7204 -0.9888 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K07 mock treatment 101120.0 -7670.0 -0.3 83760.0 -10800.0 -0.4 -0.4961 -0.9887 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K08 mock treatment 101960.0 -6830.0 -0.27 90200.0 -4320.0 -0.16 -0.3022 -0.9722 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K09 mock treatment 107080.0 -1710.0 -0.07 99880.0 5360.0 0.2 0.0952 0.4494 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K10 mock treatment 104240.0 -4550.0 -0.18 79240.0 -15300.0 -0.57 -0.5305 -0.884 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K11 mock treatment 99920.0 -8870.0 -0.34 90000.0 -4520.0 -0.17 -0.3635 -0.9469 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K12 mock treatment 106120.0 -2670.0 -0.1 88720.0 -5800.0 -0.22 -0.2273 -0.9425 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K13 mock treatment 114160.0 5370.0 0.21 76360.0 -18200.0 -0.68 -0.3348 -0.4697 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K14 mock treatment 112960.0 4170.0 0.16 80160.0 -14400.0 -0.54 -0.2668 -0.4742 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K15 mock treatment 107800.0 -994.0 -0.04 92320.0 -2200.0 -0.08 -0.0857 -0.9398 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K16 mock treatment 100720.0 -8070.0 -0.31 84000.0 -10500.0 -0.39 -0.5007 -0.9934 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K17 mock treatment 105240.0 -3550.0 -0.14 79240.0 -15300.0 -0.57 -0.5031 -0.8528 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K18 mock treatment 94080.0 -14700.0 -0.57 91000.0 -3520.0 -0.13 -0.4971 -0.8484 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K19 mock treatment 111480.0 2690.0 0.1 86920.0 -7600.0 -0.29 -0.128 -0.4215 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K20 mock treatment 101440.0 -7350.0 -0.29 85160.0 -9360.0 -0.35 -0.4502 -0.9947 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K21 mock treatment 95600.0 -13200.0 -0.51 88880.0 -5640.0 -0.21 -0.5117 -0.9237 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K22 mock treatment 108960.0 166.0 0.01 89400.0 -5120.0 -0.19 -0.1314 -0.683 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K23 mock treatment 99040.0 -9750.0 -0.38 103520.0 9000.0 0.34 -0.0288 -0.0568 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base K24 mock treatment 111840.0 3050.0 0.12 90720.0 -3800.0 -0.14 -0.0173 -0.0935 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L01 mock treatment 103600.0 -5190.0 -0.2 100880.0 6360.0 0.24 0.0262 0.084 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L02 mock treatment 103360.0 -5430.0 -0.21 103040.0 8520.0 0.32 0.077 0.201 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L03 mock treatment 100040.0 -8750.0 -0.34 91920.0 -2600.0 -0.1 -0.3092 -0.8749 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L04 mock treatment 104720.0 -4070.0 -0.16 100080.0 5560.0 0.21 0.0357 0.1366 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L05 mock treatment 104280.0 -4510.0 -0.18 81800.0 -12700.0 -0.48 -0.4615 -0.9074 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L06 mock treatment 108240.0 -554.0 -0.02 90000.0 -4520.0 -0.17 -0.1352 -0.7903 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L07 mock treatment 102160.0 -6630.0 -0.26 85240.0 -9280.0 -0.35 -0.4283 -0.9889 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L08 mock treatment 100040.0 -8750.0 -0.34 93120.0 -1400.0 -0.05 -0.2774 -0.807 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L09 mock treatment 100720.0 -8070.0 -0.31 85120.0 -9400.0 -0.35 -0.471 -0.9982 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L10 mock treatment 112760.0 3970.0 0.15 83920.0 -10600.0 -0.4 -0.1725 -0.4044 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L11 mock treatment 99960.0 -8830.0 -0.34 85240.0 -9280.0 -0.35 -0.4887 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L12 mock treatment 103720.0 -5070.0 -0.2 91200.0 -3320.0 -0.12 -0.2274 -0.9757 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L13 mock treatment 103040.0 -5750.0 -0.22 84160.0 -10400.0 -0.39 -0.4328 -0.9653 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L14 mock treatment 108080.0 -714.0 -0.03 87280.0 -7240.0 -0.27 -0.2118 -0.7752 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L15 mock treatment 101400.0 -7390.0 -0.29 86440.0 -8080.0 -0.3 -0.4173 -0.9996 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L16 mock treatment 99360.0 -9430.0 -0.37 81920.0 -12600.0 -0.47 -0.5933 -0.992 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L17 mock treatment 102320.0 -6470.0 -0.25 88160.0 -6360.0 -0.24 -0.3464 -0.9997 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L18 mock treatment 97440.0 -11400.0 -0.44 93200.0 -1320.0 -0.05 -0.3466 -0.7818 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L19 mock treatment 104280.0 -4510.0 -0.18 84600.0 -9920.0 -0.37 -0.3871 -0.9408 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L20 mock treatment 93880.0 -14900.0 -0.58 94720.0 199.0 0.01 -0.4039 -0.6979 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L21 mock treatment 102160.0 -6630.0 -0.26 92920.0 -1600.0 -0.06 -0.2245 -0.8494 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L22 mock treatment 96360.0 -12400.0 -0.48 101520.0 7000.0 0.26 -0.1554 -0.2829 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L23 mock treatment 94680.0 -14100.0 -0.55 92280.0 -2240.0 -0.08 -0.4467 -0.8063 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base L24 mock treatment 103160.0 -5630.0 -0.22 94520.0 -1.46 0.0 -0.1546 -0.7073 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M01 mock treatment 102040.0 -6750.0 -0.26 94080.0 -441.0 -0.02 -0.197 -0.7503 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M02 mock treatment 107400.0 -1390.0 -0.05 95360.0 839.0 0.03 -0.016 -0.2555 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M03 mock treatment 104040.0 -4750.0 -0.18 98680.0 4160.0 0.16 -0.0201 -0.083 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M04 mock treatment 109040.0 246.0 0.01 103760.0 9240.0 0.35 0.2519 0.7263 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M05 mock treatment 97600.0 -11200.0 -0.43 93000.0 -1520.0 -0.06 -0.3475 -0.7932 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M06 mock treatment 108520.0 -274.0 -0.01 91280.0 -3240.0 -0.12 -0.0935 -0.766 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M07 mock treatment 107400.0 -1390.0 -0.05 87280.0 -7240.0 -0.27 -0.2304 -0.8315 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M08 mock treatment 97360.0 -11400.0 -0.44 95720.0 1200.0 0.04 -0.2819 -0.6322 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M09 mock treatment 97360.0 -11400.0 -0.44 87840.0 -6680.0 -0.25 -0.491 -0.9635 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M10 mock treatment 102960.0 -5830.0 -0.23 87640.0 -6880.0 -0.26 -0.3427 -0.9978 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M11 mock treatment 109760.0 966.0 0.04 91160.0 -3360.0 -0.13 -0.0627 -0.4764 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M12 mock treatment 152120.0 43300.0 1.68 89520.0 -5000.0 -0.19 1.056 0.6243 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M13 mock treatment 97920.0 -10900.0 -0.42 89320.0 -5200.0 -0.2 -0.4364 -0.9387 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M14 mock treatment 100160.0 -8630.0 -0.33 89600.0 -4920.0 -0.18 -0.3675 -0.9606 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M15 mock treatment 99640.0 -9150.0 -0.36 92040.0 -2480.0 -0.09 -0.317 -0.8633 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M16 mock treatment 114880.0 6090.0 0.24 84160.0 -10400.0 -0.39 -0.108 -0.2374 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M17 mock treatment 102720.0 -6070.0 -0.24 90520.0 -4000.0 -0.15 -0.2728 -0.9763 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M18 mock treatment 98040.0 -10800.0 -0.42 91160.0 -3360.0 -0.13 -0.3843 -0.8815 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M19 mock treatment 98880.0 -9910.0 -0.38 90760.0 -3760.0 -0.14 -0.3718 -0.9074 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M20 mock treatment 91600.0 -17200.0 -0.67 92680.0 -1840.0 -0.07 -0.5206 -0.7762 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M21 mock treatment 109960.0 1170.0 0.05 88560.0 -5960.0 -0.22 -0.1262 -0.5529 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M22 mock treatment 104040.0 -4750.0 -0.18 91560.0 -2960.0 -0.11 -0.209 -0.9706 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M23 mock treatment 112600.0 3810.0 0.15 101680.0 7160.0 0.27 0.2944 0.9603 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base M24 mock treatment 109280.0 486.0 0.02 96720.0 2200.0 0.08 0.0717 0.8469 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N01 mock treatment 103760.0 -5030.0 -0.2 90560.0 -3960.0 -0.15 -0.2432 -0.9909 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N02 mock treatment 105120.0 -3670.0 -0.14 102600.0 8080.0 0.3 0.1136 0.3391 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N03 mock treatment 101840.0 -6950.0 -0.27 93640.0 -881.0 -0.03 -0.2142 -0.7879 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N04 mock treatment 100320.0 -8470.0 -0.33 92400.0 -2120.0 -0.08 -0.2888 -0.8537 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N05 mock treatment 101560.0 -7230.0 -0.28 94640.0 119.0 0.0 -0.1953 -0.6958 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N06 mock treatment 99640.0 -9150.0 -0.36 95000.0 479.0 0.02 -0.2384 -0.6705 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N07 mock treatment 95880.0 -12900.0 -0.5 85840.0 -8680.0 -0.33 -0.5847 -0.9783 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N08 mock treatment 107520.0 -1270.0 -0.05 93720.0 -801.0 -0.03 -0.0562 -0.9716 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N09 mock treatment 98560.0 -10200.0 -0.4 89480.0 -5040.0 -0.19 -0.4146 -0.9425 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N10 mock treatment 95400.0 -13400.0 -0.52 88560.0 -5960.0 -0.22 -0.5257 -0.9291 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N11 mock treatment 103560.0 -5230.0 -0.2 90200.0 -4320.0 -0.16 -0.2583 -0.9938 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N12 mock treatment 101680.0 -7110.0 -0.28 87040.0 -7480.0 -0.28 -0.3937 -1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N13 mock treatment 97680.0 -11100.0 -0.43 87640.0 -6880.0 -0.26 -0.4875 -0.97 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N14 mock treatment 98920.0 -9870.0 -0.38 90200.0 -4320.0 -0.16 -0.3856 -0.9268 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N15 mock treatment 99720.0 -9070.0 -0.35 82320.0 -12200.0 -0.46 -0.5728 -0.9916 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N16 mock treatment 94360.0 -14400.0 -0.56 82560.0 -12000.0 -0.45 -0.7135 -0.994 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N17 mock treatment 94760.0 -14000.0 -0.54 88120.0 -6400.0 -0.24 -0.5549 -0.9324 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N18 mock treatment 95680.0 -13100.0 -0.51 87680.0 -6840.0 -0.26 -0.5414 -0.9498 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N19 mock treatment 102520.0 -6270.0 -0.24 99600.0 5080.0 0.19 -0.0374 -0.1208 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N20 mock treatment 98360.0 -10400.0 -0.4 122520.0 28000.0 1.05 0.4568 0.4056 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N21 mock treatment 94440.0 -14400.0 -0.56 94960.0 439.0 0.02 -0.3822 -0.6859 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N22 mock treatment 94720.0 -14100.0 -0.55 95000.0 479.0 0.02 -0.3734 -0.6835 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N23 mock treatment 93240.0 -15600.0 -0.6 94800.0 279.0 0.01 -0.4193 -0.6948 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base N24 mock treatment 92800.0 -16000.0 -0.62 90200.0 -4320.0 -0.16 -0.5535 -0.8629 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O01 mock treatment 110960.0 2170.0 0.08 96000.0 1480.0 0.06 0.0987 0.9797 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O02 mock treatment 102080.0 -6710.0 -0.26 105320.0 10800.0 0.41 0.1024 0.2125 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O03 mock treatment 101480.0 -7310.0 -0.28 101520.0 7000.0 0.26 -0.0149 -0.0386 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O04 mock treatment 109160.0 366.0 0.01 113120.0 18600.0 0.7 0.5036 0.7213 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O05 mock treatment 106560.0 -2230.0 -0.09 95600.0 1080.0 0.04 -0.0327 -0.3415 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O06 mock treatment 108800.0 6.1 0.0 106960.0 12400.0 0.47 0.3303 0.7075 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O07 mock treatment 114400.0 5610.0 0.22 100320.0 5800.0 0.22 0.3077 1.0 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O08 mock treatment 103080.0 -5710.0 -0.22 92200.0 -2320.0 -0.09 -0.2184 -0.9167 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O09 mock treatment 106600.0 -2190.0 -0.09 92600.0 -1920.0 -0.07 -0.1112 -0.9966 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O10 mock treatment 109200.0 406.0 0.02 96720.0 2200.0 0.08 0.0695 0.8272 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O11 mock treatment 108080.0 -714.0 -0.03 98040.0 3520.0 0.13 0.0738 0.5469 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O12 mock treatment 106920.0 -1870.0 -0.07 87920.0 -6600.0 -0.25 -0.2266 -0.8776 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O13 mock treatment 104040.0 -4750.0 -0.18 82640.0 -11900.0 -0.45 -0.4457 -0.9237 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O14 mock treatment 98200.0 -10600.0 -0.41 86120.0 -8400.0 -0.32 -0.5136 -0.9914 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O15 mock treatment 116960.0 8170.0 0.32 96360.0 1840.0 0.07 0.2728 0.8414 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O16 mock treatment 111520.0 2730.0 0.11 96560.0 2040.0 0.08 0.1289 0.9874 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O17 mock treatment 112360.0 3570.0 0.14 102880.0 8360.0 0.31 0.3197 0.9323 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O18 mock treatment 99160.0 -9630.0 -0.37 101160.0 6640.0 0.25 -0.0881 -0.1962 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O19 mock treatment 122920.0 14100.0 0.55 105560.0 11000.0 0.41 0.6805 0.9905 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O20 mock treatment 101240.0 -7550.0 -0.29 91400.0 -3120.0 -0.12 -0.2901 -0.919 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O21 mock treatment 101520.0 -7270.0 -0.28 106680.0 12200.0 0.46 0.1231 0.2294 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O22 mock treatment 104760.0 -4030.0 -0.16 99120.0 4600.0 0.17 0.0114 0.0488 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O23 mock treatment 108320.0 -474.0 -0.02 107840.0 13300.0 0.5 0.3405 0.6806 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base O24 mock treatment 109040.0 246.0 0.01 101760.0 7240.0 0.27 0.1989 0.7315 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P01 mock treatment 116880.0 8090.0 0.31 98480.0 3960.0 0.15 0.3269 0.9417 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P02 mock treatment 110720.0 1930.0 0.07 95680.0 1160.0 0.04 0.0836 0.9668 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P03 mock treatment 98480.0 -10300.0 -0.4 97200.0 2680.0 0.1 -0.2119 -0.5135 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P04 mock treatment 106680.0 -2110.0 -0.08 94320.0 -201.0 -0.01 -0.0633 -0.769 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P05 mock treatment 98520.0 -10300.0 -0.4 95600.0 1080.0 0.04 -0.2533 -0.6321 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P06 mock treatment 96560.0 -12200.0 -0.47 94360.0 -161.0 -0.01 -0.3399 -0.7161 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P07 mock treatment 111200.0 2410.0 0.09 89760.0 -4760.0 -0.18 -0.0604 -0.2993 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P08 mock treatment 104640.0 -4150.0 -0.16 96800.0 2280.0 0.09 -0.0535 -0.2932 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P09 mock treatment 112040.0 3250.0 0.13 89000.0 -5520.0 -0.21 -0.0575 -0.237 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P10 mock treatment 112800.0 4010.0 0.16 93000.0 -1520.0 -0.06 0.0695 0.4199 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P11 mock treatment 213120.0 104000.0 4.05 97640.0 3120.0 0.12 2.945 0.7272 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P12 mock treatment 98960.0 -9830.0 -0.38 89320.0 -5200.0 -0.2 -0.4078 -0.9516 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P13 mock treatment 95000.0 -13800.0 -0.54 83480.0 -11000.0 -0.41 -0.6715 -0.992 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P14 mock treatment 103200.0 -5590.0 -0.22 82160.0 -12400.0 -0.46 -0.4815 -0.9401 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P15 mock treatment 101240.0 -7550.0 -0.29 86880.0 -7640.0 -0.29 -0.41 -0.9999 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P16 mock treatment 92400.0 -16400.0 -0.64 85520.0 -9000.0 -0.34 -0.6887 -0.9562 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P17 mock treatment 95160.0 -13600.0 -0.53 97520.0 3000.0 0.11 -0.2945 -0.5445 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P18 mock treatment 91960.0 -16800.0 -0.65 90680.0 -3840.0 -0.14 -0.5638 -0.8429 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P19 mock treatment 95200.0 -13600.0 -0.53 92400.0 -2120.0 -0.08 -0.4293 -0.8047 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P20 mock treatment 93680.0 -15100.0 -0.59 90440.0 -4080.0 -0.15 -0.523 -0.8629 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P21 mock treatment 95240.0 -13600.0 -0.53 92160.0 -2360.0 -0.09 -0.4345 -0.8148 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P22 mock treatment 94040.0 -14800.0 -0.57 101560.0 7040.0 0.26 -0.218 -0.3458 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P23 mock treatment 102000.0 -6790.0 -0.26 96280.0 1760.0 0.07 -0.1397 -0.5142 1108.0006 CellTiterGlo(1108.0006) e-CadherinSyntheticLethalAssay 1108.0006.Base P24 mock treatment 107040.0 -1750.0 -0.07 96840.0 2320.0 0.09 0.0134 0.1214