ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A01 compound treatment 74960.0 -4040.0 -0.07 57280.0 -8430.0 -0.13 -0.1421 -0.9477 1205993 ChemDiv3_000001 Cc1cc(c(O)c(c1)C(C)(C)C)n2nc3ccc(Cl)cc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A02 compound treatment 49960.0 -29000.0 -0.48 60400.0 -5310.0 -0.08 -0.3987 -0.8192 1044707 ChemDiv3_000002 OC(=O)c1ccccc1C(=O)c2ccc(cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A03 compound treatment 63200.0 -15800.0 -0.26 97880.0 32200.0 0.51 0.1782 0.3098 1699093 ChemDiv3_000003 Cc1ccc(Nc2ccc3ncnc4-c5ccccc5C(=O)c2c43)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A04 compound treatment 76720.0 -2280.0 -0.04 114520.0 48800.0 0.78 0.5236 0.6722 3117569 ChemDiv3_000004 Clc1c(sc2ccccc12)C(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A05 compound treatment 33960.0 -45000.0 -0.74 54480.0 -11200.0 -0.18 -0.6522 -0.8529 1561677 ChemDiv3_000005 CCOC(=O)c1c(O)nc2c3ccccc3oc2c1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A06 compound treatment 54920.0 -24100.0 -0.4 136840.0 71100.0 1.13 0.5207 0.4334 3117570 ChemDiv3_000006 CN(C)C(=O)C[n+]1ccc(/C=N/O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A07 compound treatment 49240.0 -29800.0 -0.49 147680.0 82000.0 1.31 0.5766 0.413 1166193 ChemDiv3_000007 CCCC1CCC(CC1)c2ccc(cc2)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A08 compound treatment 27520.0 -51500.0 -0.85 34600.0 -31100.0 -0.5 -0.9514 -0.9671 3019825 ChemDiv3_000008 C(c1ccccc1)[n+]2ccc(cc2)c3nc4ccccc4s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A09 compound treatment 2960.0 -76000.0 -1.26 7040.0 -58700.0 -0.94 -1.5487 -0.9895 1640201 ChemDiv3_000009 CCCc1ccc(OC(=O)c2ccc(O)cc2Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A10 compound treatment 4040.0 -75000.0 -1.24 8520.0 -57200.0 -0.91 -1.5194 -0.9887 1305993 ChemDiv3_000010 Cc1sc(N)nc1C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A11 compound treatment 69120.0 -9880.0 -0.16 159680.0 94000.0 1.5 0.9438 0.6264 3019826 ChemDiv3_000011 CCN1C(=O)/C(=C/C=C\2/Sc3ccccc3N2CC)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A12 compound treatment 110560.0 31600.0 0.52 177840.0 112000.0 1.79 1.6322 0.8767 1005107 ChemDiv3_000012 CC(C)(C)C(=O)C[n+]1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A13 compound treatment 57360.0 -21600.0 -0.36 77480.0 11800.0 0.19 -0.1198 -0.297 1917998 ChemDiv3_000013 CN(C)c1ccc(cc1)c2n(C)c3ccccc3[n+]2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A14 compound treatment 87240.0 8240.0 0.14 124840.0 59100.0 0.94 0.7627 0.8009 3117571 ChemDiv3_000014 O/N=C/c1cc[n+](C/C=C\c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A15 compound treatment 36920.0 -42100.0 -0.69 131920.0 66200.0 1.06 0.2551 0.2019 1511477 ChemDiv3_000015 Cc1ccc(cc1)S(=O)(=O)c2ccc(cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A16 compound treatment 22080.0 -56900.0 -0.94 79200.0 13500.0 0.22 -0.5123 -0.5315 1463254 ChemDiv3_000016 C(CN1CCOCC1)Oc2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A17 compound treatment 36760.0 -42200.0 -0.7 54160.0 -11500.0 -0.18 -0.6231 -0.8641 1289110 ChemDiv3_000017 N#CC(=c1ccc(=C(C#N)c2ccc(cc2)N3CCCC3)cc1)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A18 compound treatment 40440.0 -38600.0 -0.64 134800.0 69100.0 1.1 0.3287 0.2584 1594677 ChemDiv3_000018 CC(C)CN(CC(C)C)Cn1c(=O)oc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A19 compound treatment 45480.0 -33500.0 -0.55 117840.0 52100.0 0.83 0.1964 0.1967 1914297 ChemDiv3_000019 COc1ccc(/C=N/n2cnnc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A20 compound treatment 2360.0 -76600.0 -1.27 6760.0 -58900.0 -0.94 -1.5589 -0.9893 1550111 ChemDiv3_000020 CC(C)C1CCC(C)C(C(O)c2ccc(cc2)c3ccccc3)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A21 compound treatment 11440.0 -67600.0 -1.12 33560.0 -32100.0 -0.51 -1.1508 -0.9377 3019827 ChemDiv3_000021 CN(C)c1ccc(/C=C/C=C/c2cc[n+](C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A22 compound treatment 23160.0 -55800.0 -0.92 43760.0 -21900.0 -0.35 -0.8991 -0.912 1470588 ChemDiv3_000022 Fc1ccccc1C(=O)Oc2cccc(OC(=O)c3ccccc3F)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A23 mock treatment 49560.0 -29400.0 -0.49 50080.0 -15600.0 -0.25 -0.5197 -0.9518 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 A24 mock treatment 45920.0 -33100.0 -0.55 38480.0 -27200.0 -0.43 -0.6929 -0.9935 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B01 compound treatment 49040.0 -30000.0 -0.49 118400.0 52700.0 0.84 0.2442 0.2506 3117572 ChemDiv3_000023 COc1ccc(/C=N/c2ccc(OCC(O)CN3C(C)CCCC3C)cc2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B02 compound treatment 45560.0 -33400.0 -0.55 95680.0 30000.0 0.48 -0.0525 -0.0719 1476169 ChemDiv3_000024 CC(C)(C)NC(=O)C1(CC2CC3C1)CC(C2)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B03 compound treatment 70960.0 -8040.0 -0.13 145920.0 80200.0 1.28 0.8102 0.6304 1164812 ChemDiv3_000025 O(c1ccccc1)c2cccc(Oc3ccccc3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B04 compound treatment 41000.0 -38000.0 -0.63 118920.0 53200.0 0.85 0.1562 0.1481 3019828 ChemDiv3_000026 Brc1ccc(/C=N/C2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B05 compound treatment 3520.0 -75500.0 -1.25 8120.0 -57600.0 -0.92 -1.53 -0.9887 2083946 ChemDiv3_000027 O=C(/C=C/c1ccccc1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B06 compound treatment 28040.0 -51000.0 -0.84 102840.0 37100.0 0.59 -0.1763 -0.1714 3117574 ChemDiv3_000028 CC1(CC2(C)CC3(C)C1)CC(C/N=C/c4ccc(O)cc4)(C2)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B07 compound treatment 43760.0 -35200.0 -0.58 78480.0 12800.0 0.2 -0.2673 -0.4338 1666537 ChemDiv3_000029 COC(=O)NCC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B08 compound treatment 52160.0 -26800.0 -0.44 126200.0 60500.0 0.96 0.3685 0.3473 1021487 ChemDiv3_000030 C1CN(CCN1c2ccccn2)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B09 compound treatment 35840.0 -43200.0 -0.71 136600.0 70900.0 1.13 0.2953 0.221 3019829 ChemDiv3_000031 COc1ccc(/C=N/c2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B10 compound treatment 74400.0 -4600.0 -0.08 160760.0 95100.0 1.52 1.0176 0.6709 1699181 ChemDiv3_000032 Cc1c(NC(=O)c2ccccc2)c(=O)n(c3ccccc3)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B11 compound treatment 60400.0 -18600.0 -0.31 131520.0 65800.0 1.05 0.5247 0.48 3019830 ChemDiv3_000033 CC(C)Cc1ccc(cc1)C(C)C(=O)NC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B12 compound treatment 124960.0 46000.0 0.76 117720.0 52000.0 0.83 1.1227 0.999 3117575 ChemDiv3_000034 COc1ccc(/C=C/2\CC/C(=C\c3ccc(C)cc3)/C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B13 compound treatment 130640.0 51600.0 0.85 146200.0 80500.0 1.28 1.51 0.9803 1119180 ChemDiv3_000035 CNC(=O)c1ccc(Oc2ccc(cc2)C(=O)NC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B14 compound treatment 11280.0 -67700.0 -1.12 14600.0 -51100.0 -0.81 -1.3664 -0.9879 1616129 ChemDiv3_000036 CC(=O)Nc1cccc(Oc2ccc3C(=O)N(C(=O)c3c2)c4ccc(Oc5ccc(C)c(C)c5)cc4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B15 compound treatment 82200.0 3200.0 0.05 168480.0 103000.0 1.64 1.1957 0.7296 1336672 ChemDiv3_000037 O=C(Nc1cc(=O)c2ccccc2o1)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B16 compound treatment 48280.0 -30700.0 -0.51 143480.0 77800.0 1.24 0.518 0.3868 3117576 ChemDiv3_000038 CC[n+]1ccc(C)c2cc(ccc12)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B17 compound treatment 40640.0 -38400.0 -0.63 82120.0 16400.0 0.26 -0.2627 -0.3835 3019831 ChemDiv3_000039 NNC(=S)NC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B18 compound treatment 38320.0 -40700.0 -0.67 131920.0 66200.0 1.06 0.2715 0.217 1270265 ChemDiv3_000040 Clc1ccc(cc1)S(=O)(=O)n2cnc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B19 compound treatment 38600.0 -40400.0 -0.67 143320.0 77600.0 1.24 0.4032 0.2869 3117577 ChemDiv3_000041 Cc1cc(nc2ccc3ccccc3c12)c4ccc5ccccc5n4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B20 compound treatment 21200.0 -57800.0 -0.95 102280.0 36600.0 0.58 -0.2624 -0.2347 1591919 ChemDiv3_000042 CNc1ccc(cc1)S(=O)(=O)c2ccc(NC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B21 compound treatment 2400.0 -76600.0 -1.26 6080.0 -59600.0 -0.95 -1.566 -0.9901 3117578 ChemDiv3_000043 O=C(C1=C(C(=O)c2ccccc2C1=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B22 compound treatment 22520.0 -56500.0 -0.93 73880.0 8180.0 0.13 -0.5671 -0.6024 1583295 ChemDiv3_000044 Brc1ccc(OC(=O)c2cccnc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B23 mock treatment 51840.0 -27200.0 -0.45 92760.0 27100.0 0.43 -0.0121 -0.0194 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 B24 mock treatment 47640.0 -31400.0 -0.52 96400.0 30700.0 0.49 -0.0201 -0.0282 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C01 compound treatment 56520.0 -22500.0 -0.37 85840.0 20100.0 0.32 -0.0354 -0.0722 3019835 ChemDiv3_000045 Cc1ccn(CN2CCN(Cn3ccc(C)n3)C2=S)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C02 compound treatment 67840.0 -11200.0 -0.18 103400.0 37700.0 0.6 0.2946 0.4688 1183514 ChemDiv3_000046 CC(=O)Oc1ccc(C(=O)c2ccccc2)c(OC(=O)C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C03 compound treatment 38800.0 -40200.0 -0.66 46800.0 -18900.0 -0.3 -0.6822 -0.9362 1699403 ChemDiv3_000047 O=C(NC1(CCC(=O)O1)C(=O)OCc2ccccc2)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C04 compound treatment 58240.0 -20800.0 -0.34 109920.0 44200.0 0.7 0.256 0.3267 3019836 ChemDiv3_000048 COc1ccc(NC(=S)C)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C05 compound treatment 29440.0 -49600.0 -0.82 82240.0 16500.0 0.26 -0.3921 -0.4562 3019837 ChemDiv3_000049 Clc1ccc(OC(=O)c2ccc(Br)cc2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C06 compound treatment 74120.0 -4880.0 -0.08 111240.0 45500.0 0.73 0.4563 0.6249 3117579 ChemDiv3_000050 CC(C)N(C(C)C)C(=O)C[n+]1ccc(/C=N/O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C07 compound treatment 32840.0 -46200.0 -0.76 82320.0 16600.0 0.26 -0.3515 -0.4358 1112119 ChemDiv3_000051 CC(=O)Oc1ccc(cc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C08 compound treatment 58440.0 -20600.0 -0.34 119160.0 53500.0 0.85 0.3625 0.3953 1921020 ChemDiv3_000052 CC[n+]1cccc(c1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C09 compound treatment 4880.0 -74100.0 -1.22 11000.0 -54700.0 -0.87 -1.4817 -0.9862 1233273 ChemDiv3_000053 CCN1CCN(CC1)c2ccc(Nc3ccnc4cc5ccccc5cc34)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C10 compound treatment 65080.0 -13900.0 -0.23 145920.0 80200.0 1.28 0.7416 0.5709 3019838 ChemDiv3_000054 NC(=O)N1CCc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C11 compound treatment 9960.0 -69000.0 -1.14 12080.0 -53600.0 -0.85 -1.4102 -0.9899 1021994 ChemDiv3_000055 Oc1ccc(cc1)C2(CCCCC2)c3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C12 compound treatment 144800.0 65800.0 1.09 137640.0 71900.0 1.15 1.5788 0.9996 3019839 ChemDiv3_000056 CC(C)(C)OC(=O)C[n+]1cccc(c1)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C13 compound treatment 131240.0 52200.0 0.86 158280.0 92600.0 1.48 1.6531 0.9673 3117584 ChemDiv3_000057 O=C1CN(C(=O)N1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C14 compound treatment 94720.0 15700.0 0.26 128760.0 63100.0 1.01 0.8942 0.8615 3019840 ChemDiv3_000058 O/N=C/c1cc[n+](CC(=O)N2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C15 compound treatment 80800.0 1800.0 0.03 140200.0 74500.0 1.19 0.8606 0.7246 1320550 ChemDiv3_000059 COC(=O)CCS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)CCC(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C16 compound treatment 50680.0 -28300.0 -0.47 140480.0 74800.0 1.19 0.5122 0.4001 1778026 ChemDiv3_000060 OCc1c(CO)[n+]([O-])c2ccccc2[n+]1[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C17 compound treatment 61480.0 -17500.0 -0.29 134760.0 69100.0 1.1 0.5738 0.5042 3019841 ChemDiv3_000061 Cc1ccc(cc1)C(=O)C2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C18 compound treatment 55160.0 -23800.0 -0.39 136640.0 70900.0 1.13 0.5212 0.4354 1353751 ChemDiv3_000062 Clc1cccc(NCn2c(=O)oc3ccccc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C19 compound treatment 36800.0 -42200.0 -0.7 55760.0 -9950.0 -0.16 -0.6046 -0.8464 1912422 ChemDiv3_000063 CCc1ccc(/N=C/c2c[nH]c3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C20 compound treatment 21040.0 -58000.0 -0.96 23760.0 -41900.0 -0.67 -1.1492 -0.9846 1318161 ChemDiv3_000064 C(N1CCOCCN(Cc2ccccc2)CCOCC1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C21 compound treatment 28480.0 -50500.0 -0.83 105560.0 39900.0 0.64 -0.1405 -0.134 1038768 ChemDiv3_000065 CCN(CC)c1ccc2c(C)cc(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C22 compound treatment 14360.0 -64600.0 -1.07 62000.0 -3710.0 -0.06 -0.7962 -0.7451 3019842 ChemDiv3_000066 O=C(Oc1ccc(cc1)c2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C23 mock treatment 49640.0 -29400.0 -0.48 99320.0 33600.0 0.54 0.0362 0.0501 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 C24 mock treatment 45440.0 -33600.0 -0.55 67320.0 1620.0 0.03 -0.3735 -0.6735 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D01 compound treatment 37360.0 -41600.0 -0.69 72560.0 6860.0 0.11 -0.4087 -0.5873 3117585 ChemDiv3_000067 C(Sc1nnnn1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D02 compound treatment 59760.0 -19200.0 -0.32 121680.0 56000.0 0.89 0.4063 0.4291 3117586 ChemDiv3_000068 CC(C)(C)C(/C=C/c1ccc(Cl)cc1Cl)n2nnnc2C(C)(C)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D03 compound treatment 90520.0 11500.0 0.19 113760.0 48100.0 0.77 0.6761 0.8567 1053376 ChemDiv3_000069 OC(=O)C1C(C(C1c2ccccc2)C(=O)O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D04 compound treatment 18080.0 -60900.0 -1.01 18920.0 -46800.0 -0.75 -1.2383 -0.9892 3117587 ChemDiv3_000070 O=C(/C=C/N1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D05 compound treatment 39760.0 -39200.0 -0.65 45680.0 -20000.0 -0.32 -0.6837 -0.9468 3019843 ChemDiv3_000071 c1cncc(c1)c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D06 compound treatment 49360.0 -29600.0 -0.49 49640.0 -16100.0 -0.26 -0.527 -0.9544 1343691 ChemDiv3_000072 CCN(C)CC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D07 compound treatment 50120.0 -28900.0 -0.48 113840.0 48100.0 0.77 0.2054 0.2275 1187732 ChemDiv3_000073 COC(=O)NC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D08 compound treatment 6280.0 -72700.0 -1.2 10080.0 -55600.0 -0.89 -1.4757 -0.9889 1355186 ChemDiv3_000074 Nc1ccc(Sc2ccc3ccccc3c2Cl)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D09 compound treatment 61960.0 -17000.0 -0.28 116080.0 50400.0 0.8 0.3689 0.4336 1016949 ChemDiv3_000075 NC(=N)NC(=N)NCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D10 compound treatment 80160.0 1160.0 0.02 120080.0 54400.0 0.87 0.6264 0.7226 1392304 ChemDiv3_000076 Clc1ccc(cc1)c2nnc(o2)C3CCC(CC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D11 compound treatment 51760.0 -27200.0 -0.45 99360.0 33700.0 0.54 0.0614 0.0877 1388409 ChemDiv3_000077 S=c1sc2ccccc2n1CN3CCN(Cc4ccccc4)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D12 compound treatment 133680.0 54700.0 0.9 123240.0 57500.0 0.92 1.2867 1.0 3117588 ChemDiv3_000078 COc1ccc(/C=C/2\CC/C(=C\c3ccc(Cl)cc3)/C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D13 compound treatment 21760.0 -57200.0 -0.94 20720.0 -45000.0 -0.72 -1.1751 -0.9907 1025986 ChemDiv3_000079 Cc1ccccc1NC(=O)c2cc3ccccc3cc2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D14 compound treatment 52760.0 -26200.0 -0.43 125880.0 60200.0 0.96 0.3719 0.3534 1513086 ChemDiv3_000080 O=C(COc1ccc2ccccc2c1)NS(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D15 compound treatment 82680.0 3680.0 0.06 153800.0 88100.0 1.4 1.0358 0.737 1550944 ChemDiv3_000081 O=C(N1CC(CC1=O)c2ccccc2)c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D16 compound treatment 40400.0 -38600.0 -0.64 72320.0 6620.0 0.11 -0.376 -0.5822 1432699 ChemDiv3_000082 CCOC(=O)c1cccc(n1)C(=O)Nc2nc3ccc(OC)cc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D17 compound treatment 45120.0 -33900.0 -0.56 86120.0 20400.0 0.33 -0.1653 -0.2555 1601789 ChemDiv3_000083 Cc1ccc(NC(=O)CC2(CC3CC4CC(C3)C2)C4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D18 compound treatment 22520.0 -56500.0 -0.93 37080.0 -28600.0 -0.46 -0.9818 -0.946 3019844 ChemDiv3_000084 CC(C)OC(=O)n1c(=S)oc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D19 compound treatment 49160.0 -29800.0 -0.49 155320.0 89600.0 1.43 0.6617 0.438 1581559 ChemDiv3_000085 O=C(Oc1ccc(OC(=O)c2ccccc2)cc1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D20 compound treatment 5720.0 -73300.0 -1.21 15040.0 -50700.0 -0.81 -1.4263 -0.9807 3117589 ChemDiv3_000086 O=S(=O)(/C=C/c1ccccc1)N2C=Cc3ccccc3C2c4c[nH]c5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D21 compound treatment 29400.0 -49600.0 -0.82 110560.0 44900.0 0.71 -0.0734 -0.0675 1529969 ChemDiv3_000087 Nc1nnc(s1)C(=O)c2ccccc2N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D22 compound treatment 3520.0 -75500.0 -1.25 6040.0 -59700.0 -0.95 -1.5534 -0.9911 1119404 ChemDiv3_000088 CCCC1CCC(CC1)c2ccc(OC(=O)c3cccnc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D23 mock treatment 43520.0 -35500.0 -0.59 62360.0 -3350.0 -0.05 -0.4518 -0.7683 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 D24 mock treatment 30080.0 -48900.0 -0.81 73920.0 8220.0 0.13 -0.4784 -0.5848 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E01 compound treatment 52720.0 -26300.0 -0.43 86400.0 20700.0 0.33 -0.0735 -0.1348 3019845 ChemDiv3_000089 C1OC(OCC2OC(OC12)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E02 compound treatment 29520.0 -49500.0 -0.82 47920.0 -17800.0 -0.28 -0.7779 -0.8999 1616713 ChemDiv3_000090 CCCOc1ccc(N)cc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E03 compound treatment 74240.0 -4760.0 -0.08 93600.0 27900.0 0.44 0.2589 0.5734 3117590 ChemDiv3_000091 COc1ccc(cc1OC)C(=O)CN2Cc3ccccc3C2=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E04 compound treatment 104520.0 25500.0 0.42 113760.0 48100.0 0.77 0.8395 0.9604 3019846 ChemDiv3_000092 COc1ccc(NC(=O)C)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E05 compound treatment 99160.0 20200.0 0.33 103640.0 37900.0 0.6 0.6629 0.9605 3019847 ChemDiv3_000093 Nc1nc(cc[n+]1[O-])c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E06 compound treatment 100520.0 21500.0 0.36 117720.0 52000.0 0.83 0.8375 0.9285 3117591 ChemDiv3_000094 O/N=C/c1cc[n+](CC(=O)NC2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E07 compound treatment 88760.0 9760.0 0.16 119400.0 53700.0 0.86 0.7191 0.8258 1701731 ChemDiv3_000095 CCc1ccc(cc1)C(=O)Oc2ccc(C#N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E08 compound treatment 84520.0 5520.0 0.09 136600.0 70900.0 1.13 0.8635 0.7617 1069596 ChemDiv3_000096 COC(=O)N1C(C=Cc2ccccc12)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E09 compound treatment 43360.0 -35600.0 -0.59 30960.0 -34700.0 -0.55 -0.8075 -0.9995 3019848 ChemDiv3_000097 N/N=C/c1ccc(cc1)S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E10 compound treatment 102480.0 23500.0 0.39 143840.0 78100.0 1.25 1.1547 0.8853 3117592 ChemDiv3_000098 CN1CCN(CC1)C(=O)/C=C(/C)\C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E11 compound treatment 128640.0 49600.0 0.82 158640.0 92900.0 1.48 1.6269 0.961 1026004 ChemDiv3_000099 COc1ccc2ccccc2c1c3c(OC)ccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E12 compound treatment 148240.0 69200.0 1.14 139880.0 74200.0 1.18 1.6442 0.9999 3019849 ChemDiv3_000100 CC(C)(C)C(=O)C[n+]1cccc(c1)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E13 compound treatment 135680.0 56700.0 0.94 132080.0 66400.0 1.06 1.4097 0.9981 1049039 ChemDiv3_000101 CC(=O)N(Nc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E14 compound treatment 94120.0 15100.0 0.25 121720.0 56000.0 0.89 0.8078 0.8714 3117593 ChemDiv3_000102 O/N=C/c1ccc[n+](CC(=O)NC2(CC3CC4CC(C3)C2)C4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E15 compound treatment 101360.0 22400.0 0.37 141920.0 76200.0 1.21 1.12 0.8822 3019850 ChemDiv3_000103 CSc1ccc(cc1)c2ccc(SC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E16 compound treatment 39360.0 -39600.0 -0.65 37520.0 -28200.0 -0.45 -0.7803 -0.9832 3019851 ChemDiv3_000104 Nc1ccc(cc1)S(=O)(=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E17 compound treatment 110000.0 31000.0 0.51 148080.0 82400.0 1.31 1.2903 0.9156 1913805 ChemDiv3_000105 CC(C)(C)OC(=O)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E18 compound treatment 77320.0 -1680.0 -0.03 119160.0 53500.0 0.85 0.5829 0.6838 1334112 ChemDiv3_000106 Cc1ccc(NCn2c(=O)oc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E19 compound treatment 106960.0 28000.0 0.46 143440.0 77700.0 1.24 1.2025 0.9095 1464160 ChemDiv3_000107 OCCNC(=O)c1cc2ccccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E20 compound treatment 83720.0 4720.0 0.08 137400.0 71700.0 1.14 0.8632 0.7536 1484925 ChemDiv3_000108 CC(NS(=O)(=O)c1ccc(C)cc1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E21 compound treatment 13640.0 -65400.0 -1.08 28200.0 -37500.0 -0.6 -1.1856 -0.9612 3117594 ChemDiv3_000109 [O-][S+]1NN([S+]([O-])NN1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E22 compound treatment 32560.0 -46400.0 -0.77 59200.0 -6510.0 -0.1 -0.6153 -0.7955 1033254 ChemDiv3_000110 COc1cc(NCCCC(C)N)c2ncccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E23 mock treatment 56560.0 -22400.0 -0.37 73400.0 7700.0 0.12 -0.1752 -0.449 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 E24 mock treatment 27240.0 -51800.0 -0.85 78320.0 12600.0 0.2 -0.4619 -0.5263 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F01 compound treatment 29480.0 -49500.0 -0.82 72600.0 6900.0 0.11 -0.5003 -0.6066 1915982 ChemDiv3_000111 O=C1NC(=O)/C(=C/c2ccccc2)/C(=O)N1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F02 compound treatment 23600.0 -55400.0 -0.91 47000.0 -18700.0 -0.3 -0.8574 -0.8915 1272580 ChemDiv3_000112 CC(=C)CN1c2ccccc2Sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F03 compound treatment 24800.0 -54200.0 -0.89 29520.0 -36200.0 -0.58 -1.0404 -0.9774 1220799 ChemDiv3_000113 Cc1ccc(Nc2ccc3noc4-c5ccccc5C(=O)c2c43)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F04 compound treatment 94360.0 15400.0 0.25 89400.0 23700.0 0.38 0.4464 0.9812 1191611 ChemDiv3_000114 O=c1oc2ccccc2c(Nc3ccccc3)c1CN4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F05 compound treatment 110440.0 31400.0 0.52 98960.0 33300.0 0.53 0.7418 0.9999 1052238 ChemDiv3_000115 COc1ccc(C=C2C(=O)NC(=O)NC2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F06 compound treatment 147680.0 68700.0 1.13 141840.0 76100.0 1.21 1.6598 0.9994 1363766 ChemDiv3_000116 Cc1cccc(c1)N(CC(=O)O)CC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F07 compound treatment 20200.0 -58800.0 -0.97 22640.0 -43100.0 -0.69 -1.1716 -0.9856 1561715 ChemDiv3_000117 O=C(Nc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F08 compound treatment 40080.0 -38900.0 -0.64 31440.0 -34300.0 -0.55 -0.8404 -0.9967 1160251 ChemDiv3_000118 CCCC1CCC(CC1)c2ccc(OC(=O)c3ccco3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F09 compound treatment 13880.0 -65100.0 -1.07 14600.0 -51100.0 -0.81 -1.336 -0.9906 1185575 ChemDiv3_000119 Cc1cc(F)ccc1S(=O)(=O)NCC2CC3CCC2C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F10 compound treatment 68400.0 -10600.0 -0.17 59200.0 -6510.0 -0.1 -0.197 -0.9688 1298807 ChemDiv3_000120 OCC(O)C1OC(Nc2ccc(Cl)cc2)C(O)C1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F11 compound treatment 77240.0 -1760.0 -0.03 109600.0 43900.0 0.7 0.4742 0.6772 1454827 ChemDiv3_000121 CC(C)(c1ccccc1)c2cc(CN3CCOCC3)c(O)c(CN4CCOCC4)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F12 compound treatment 144880.0 65900.0 1.09 126440.0 60700.0 0.97 1.4535 0.9983 1403981 ChemDiv3_000122 COc1ccc2oc(=O)c(cc2c1)c3cnc(C)s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F13 compound treatment 143520.0 64500.0 1.07 132240.0 66500.0 1.06 1.503 1.0 3117595 ChemDiv3_000123 O/N=C(\C(=O)c1ccccc1Cl)/n2cncn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F14 compound treatment 93960.0 15000.0 0.25 28000.0 -37700.0 -0.6 -0.2503 -0.3852 3117598 ChemDiv3_000124 CC1(C)COP(=S)(OC1)C(Nc2ccc(Cl)cc2)c3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F15 compound treatment 128760.0 49800.0 0.82 141760.0 76100.0 1.21 1.438 0.982 1605115 ChemDiv3_000125 Oc1ccccc1c2nsnc2C(=O)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F16 compound treatment 76320.0 -2680.0 -0.04 92200.0 26500.0 0.42 0.2674 0.6297 1419832 ChemDiv3_000126 O=C(Oc1ccc(cc1)S(=O)(=O)c2ccc(OC(=O)c3cccs3)cc2)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F17 compound treatment 9800.0 -69200.0 -1.14 11360.0 -54300.0 -0.87 -1.4202 -0.9907 1721700 ChemDiv3_000127 COc1cccc(c1)C2(CCCC2)c3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F18 compound treatment 126600.0 47600.0 0.79 134680.0 69000.0 1.1 1.333 0.9864 1321397 ChemDiv3_000128 Nc1ncn(CC(O)CO)c2nc(Br)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F19 compound treatment 121600.0 42600.0 0.7 138120.0 72400.0 1.15 1.3134 0.9718 3019915 ChemDiv3_000129 COc1ccc(cc1)C(=O)C[n+]2ccc3n(C)nnc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F20 compound treatment 123120.0 44100.0 0.73 107280.0 41600.0 0.66 0.9836 0.9989 1406847 ChemDiv3_000130 CCCC1CCC(CC1)c2ccc(OC(=O)c3cccs3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F21 compound treatment 46600.0 -32400.0 -0.53 86560.0 20900.0 0.33 -0.1431 -0.2273 1504493 ChemDiv3_000131 CC(=O)N1C(NC(=S)N)C(=O)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F22 compound treatment 33680.0 -45300.0 -0.75 62960.0 -2750.0 -0.04 -0.5599 -0.7472 1667131 ChemDiv3_000132 CCOc1ccc(OC(=O)c2cccnc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F23 mock treatment 65560.0 -13400.0 -0.22 92040.0 26300.0 0.42 0.14 0.2948 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 F24 mock treatment 25440.0 -53600.0 -0.88 91080.0 25400.0 0.4 -0.3391 -0.3489 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G01 compound treatment 42920.0 -36100.0 -0.6 60680.0 -5030.0 -0.08 -0.4777 -0.795 1210291 ChemDiv3_000133 CN(C)CCOC(=O)c1ccc2[nH]c3CCSCc3c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G02 compound treatment 46120.0 -32900.0 -0.54 47440.0 -18300.0 -0.29 -0.5896 -0.9574 1432983 ChemDiv3_000134 O=C(CC1(CC2CC3CC(C2)C1)C3)N4CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G03 compound treatment 78160.0 -836.0 -0.01 88120.0 22400.0 0.36 0.2429 0.6793 3019916 ChemDiv3_000135 CC(Cc1ccccc1)[n+]2cc(N)on2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G04 compound treatment 19120.0 -59900.0 -0.99 12680.0 -53000.0 -0.85 -1.2965 -0.997 1091968 ChemDiv3_000136 Nc1ccc(Br)cc1C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G05 compound treatment 8080.0 -70900.0 -1.17 7800.0 -57900.0 -0.92 -1.4804 -0.9931 1446265 ChemDiv3_000137 CC(=O)Oc1ccc2ccc3ccc(OC(=O)C)c4ccc1c2c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G06 compound treatment 111400.0 32400.0 0.53 127120.0 61400.0 0.98 1.0704 0.9596 3019918 ChemDiv3_000138 O/N=C/c1ccc[n+](CC(=O)NCc2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G07 compound treatment 102440.0 23400.0 0.39 116720.0 51000.0 0.81 0.8486 0.9424 3117599 ChemDiv3_000139 CC1CCC/C(=C/c2ccc(Cl)cc2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G08 compound treatment 69480.0 -9520.0 -0.16 76560.0 10900.0 0.17 0.0113 0.0482 1662647 ChemDiv3_000140 CCOC(=O)NC(=S)Nc1ccc(NC(=O)c2cc(Cl)ccc2O)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G09 compound treatment 125400.0 46400.0 0.77 135440.0 69700.0 1.11 1.3276 0.9835 1320817 ChemDiv3_000141 CCN(CC)C(=O)N1CCN(CCC#N)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G10 compound treatment 114880.0 35900.0 0.59 127640.0 61900.0 0.99 1.1169 0.9702 1913999 ChemDiv3_000142 CC(Cc1c[nH]c2ccccc12)NC(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G11 compound treatment 109600.0 30600.0 0.51 61520.0 -4190.0 -0.07 0.3101 0.6085 3117600 ChemDiv3_000143 S=c1nc(oc2CCCCc21)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G12 compound treatment 152360.0 73400.0 1.21 142720.0 77000.0 1.23 1.7243 1.0 3019921 ChemDiv3_000144 CC(C)(C)C(=O)C[n+]1ccc(cc1)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G13 compound treatment 57480.0 -21500.0 -0.36 55160.0 -10500.0 -0.17 -0.37 -0.9416 1032623 ChemDiv3_000145 O=C(N(Nc1ccccc1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G14 compound treatment 142280.0 63300.0 1.04 132040.0 66300.0 1.06 1.4863 1.0 3117601 ChemDiv3_000146 OC(=O)c1ccc(NC(=O)C[n+]2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G15 compound treatment 141840.0 62800.0 1.04 155600.0 89900.0 1.43 1.7467 0.9874 3117602 ChemDiv3_000147 CSc1ccc(Sc2ccc(SC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G16 compound treatment 137000.0 58000.0 0.96 111400.0 45700.0 0.73 1.192 0.9909 1075919 ChemDiv3_000148 Clc1ccc(OCC(=O)NCCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G17 compound treatment 122040.0 43000.0 0.71 125560.0 59900.0 0.95 1.177 0.9895 1146554 ChemDiv3_000149 OCC1(C(=O)c2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G18 compound treatment 90400.0 11400.0 0.19 99560.0 33900.0 0.54 0.5147 0.9006 1723737 ChemDiv3_000150 NC(=S)c1cc2ccccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G19 compound treatment 130240.0 51200.0 0.85 145240.0 79500.0 1.27 1.4945 0.9807 1601550 ChemDiv3_000151 COc1ccc(C2C(=O)c3ccccc3C2=O)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G20 compound treatment 134960.0 56000.0 0.92 128760.0 63100.0 1.01 1.3639 0.9991 1302822 ChemDiv3_000152 Cc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G21 compound treatment 135840.0 56800.0 0.94 132360.0 66700.0 1.06 1.4147 0.9981 3019795 ChemDiv3_000153 S=C1NN=C(C(N1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G22 compound treatment 108160.0 29200.0 0.48 105400.0 39700.0 0.63 0.7878 0.9909 1416806 ChemDiv3_000154 Nc1ccc(cc1)C(=O)Nc2ccc(cc2N)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G23 mock treatment 77040.0 -1960.0 -0.03 103240.0 37500.0 0.6 0.4002 0.668 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 G24 mock treatment 51400.0 -27600.0 -0.46 60480.0 -5230.0 -0.08 -0.381 -0.8227 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H01 compound treatment 50400.0 -28600.0 -0.47 47320.0 -18400.0 -0.29 -0.541 -0.9737 1123126 ChemDiv3_000155 C(CN1CCOCC1)Sc2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H02 compound treatment 59720.0 -19300.0 -0.32 71400.0 5700.0 0.09 -0.1608 -0.486 3019817 ChemDiv3_000156 CCOC(=O)c1c(C)c(C)sc1/N=C/c2ccc(cc2)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H03 compound treatment 88480.0 9480.0 0.16 87560.0 21900.0 0.35 0.357 0.9348 3117603 ChemDiv3_000157 CCOC(=O)c1c(C)c(C)sc1/N=C/c2ccccc2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H04 compound treatment 57560.0 -21400.0 -0.35 51920.0 -13800.0 -0.22 -0.4056 -0.9737 3019818 ChemDiv3_000158 COc1ccc(cc1)N(C(=O)/C=C/c2ccc(OC)c(OC)c2)C3=CC4CCC(C3)N4C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H05 compound treatment 144040.0 65000.0 1.07 119040.0 53300.0 0.85 1.3603 0.9933 1020750 ChemDiv3_000159 NC(=O)c1ccc[n+](CC(=O)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H06 compound treatment 148920.0 69900.0 1.15 152240.0 86500.0 1.38 1.7914 0.9961 1221336 ChemDiv3_000160 Cc1ccc(OC(=O)c2ccccc2)c(c1)n3nc4ccccc4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H07 compound treatment 55520.0 -23500.0 -0.39 52600.0 -13100.0 -0.21 -0.4217 -0.9579 1171342 ChemDiv3_000161 COC(=O)NC(=S)Nc1ccc(Oc2ccc(Cl)cc2Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H08 compound treatment 77720.0 -1280.0 -0.02 83880.0 18200.0 0.29 0.1899 0.654 1054931 ChemDiv3_000162 O=C(Oc1ccc(cc1)c2ccccc2)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H09 compound treatment 137960.0 59000.0 0.97 123880.0 58200.0 0.93 1.3439 0.9997 1080023 ChemDiv3_000163 O=C1C2C3CC(C=C3)C2C(=O)N1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H10 compound treatment 91920.0 12900.0 0.21 65680.0 -25.0 0.0 0.1506 0.7058 1270809 ChemDiv3_000164 Cc1ccccc1C(=O)N2N=C(CC2c3nc4ccccc4[nH]3)c5ccc(Br)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H11 compound treatment 144200.0 65200.0 1.08 119120.0 53400.0 0.85 1.3631 0.9933 1111851 ChemDiv3_000165 OCc1nc2cc3ccccc3cc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H12 compound treatment 166240.0 87200.0 1.44 153960.0 88300.0 1.41 2.013 0.9999 3117604 ChemDiv3_000166 O=C1N(C(=O)c2cc(ccc12)c3ncc(o3)c4ccccc4)c5ncn[nH]5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H13 compound treatment 42040.0 -37000.0 -0.61 31920.0 -33800.0 -0.54 -0.8121 -0.9981 3019820 ChemDiv3_000167 Oc1ccccc1/C=N/n2c3ccccc3c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H14 compound treatment 152160.0 73200.0 1.21 129240.0 63500.0 1.01 1.57 0.9962 3117605 ChemDiv3_000168 C/N=C(\C)/c1c(O)c2ccccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H15 compound treatment 13240.0 -65800.0 -1.09 12000.0 -53700.0 -0.86 -1.3728 -0.9931 1279829 ChemDiv3_000169 Oc1ccccc1C2CCCCC2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H16 compound treatment 133880.0 54900.0 0.91 94280.0 28600.0 0.46 0.9627 0.9494 1311336 ChemDiv3_000170 Nc1cccc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3cccc(N)c3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H17 compound treatment 17320.0 -61700.0 -1.02 13120.0 -52600.0 -0.84 -1.3126 -0.9953 1341633 ChemDiv3_000171 Cc1cc(C)c2ccc(NN)nc2c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H18 compound treatment 179040.0 100000.0 1.65 144040.0 78300.0 1.25 2.0506 0.9905 3117606 ChemDiv3_000172 CC(=O)Nc1c(C)nn(c1O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H19 compound treatment 103240.0 24200.0 0.4 103440.0 37700.0 0.6 0.7083 0.9804 3019822 ChemDiv3_000173 COc1ccc2nc(C)cc(S)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H20 compound treatment 139480.0 60500.0 1.0 120280.0 54600.0 0.87 1.3211 0.9976 1016095 ChemDiv3_000174 COC(=O)c1cccc(n1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H21 compound treatment 56880.0 -22100.0 -0.37 43400.0 -22300.0 -0.36 -0.5095 -0.9999 1229822 ChemDiv3_000175 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)Nc2ccc(I)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H22 compound treatment 120920.0 41900.0 0.69 92040.0 26300.0 0.42 0.7862 0.9713 1484239 ChemDiv3_000176 CC(C)OC(=O)c1cccc(n1)C(=O)Nc2ccc(NC(=O)C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H23 mock treatment 81400.0 2400.0 0.04 115640.0 49900.0 0.8 0.5908 0.7414 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 H24 mock treatment 54680.0 -24300.0 -0.4 40800.0 -24900.0 -0.4 -0.5645 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I01 compound treatment 74880.0 -4120.0 -0.07 47480.0 -18200.0 -0.29 -0.2534 -0.8496 1528297 ChemDiv3_000177 CCN(CC)C(=O)COc1ccc(C)nc1CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I02 compound treatment 87080.0 8080.0 0.13 53840.0 -11900.0 -0.19 -0.0394 -0.1701 1726229 ChemDiv3_000178 O=C(NC1CCCCC1)NC2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I03 compound treatment 127520.0 48500.0 0.8 94360.0 28700.0 0.46 0.8893 0.9645 1695838 ChemDiv3_000179 OC(=O)c1ccc2C(=O)c3ccccc3S(=O)(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I04 compound treatment 149440.0 70400.0 1.16 160480.0 94800.0 1.51 1.8904 0.9916 1706757 ChemDiv3_000180 CCCN(CCC)C(=O)Cn1ccc(=N)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I05 compound treatment 157160.0 78200.0 1.29 126480.0 60800.0 0.97 1.5973 0.99 3019863 ChemDiv3_000181 OC(=O)c1ccc(cc1)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I06 compound treatment 99720.0 20700.0 0.34 84480.0 18800.0 0.3 0.4535 0.9978 3117607 ChemDiv3_000182 C[N+](C)(CCOc1ccccc1)Cc2ccccc2.OC(=O)c1cc2ccccc2c(Br)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I07 compound treatment 191720.0 113000.0 1.86 130520.0 64800.0 1.03 2.0462 0.9614 1103446 ChemDiv3_000183 OC(=O)C(Cc1ccccc1)NC=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I08 compound treatment 153280.0 74300.0 1.23 146360.0 80700.0 1.29 1.7761 0.9997 3019864 ChemDiv3_000184 NC(=S)/N=C/1\CCCCC1=C2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I09 compound treatment 158960.0 80000.0 1.32 104320.0 38600.0 0.62 1.3686 0.9397 3117608 ChemDiv3_000185 Clc1ccc(cc1)S(=O)(=O)/N=C/2\SCCN2S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I10 compound treatment 167240.0 88200.0 1.46 151480.0 85800.0 1.37 1.9967 0.9995 3019865 ChemDiv3_000186 NC(=O)c1ccc[n+](CC(=O)N(CC=C)CC=C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I11 compound treatment 97000.0 18000.0 0.3 68960.0 3260.0 0.05 0.2468 0.8182 1008424 ChemDiv3_000187 Nc1ccc(Sc2ccc(N)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I12 compound treatment 191600.0 113000.0 1.86 160720.0 95000.0 1.51 2.3852 0.9948 3117609 ChemDiv3_000188 CC(C)(C)OC(=O)C[n+]1ccc(cc1)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I13 compound treatment 169840.0 90800.0 1.5 151720.0 86000.0 1.37 2.0298 0.999 1590292 ChemDiv3_000189 Cc1ccc(cc1)C(=O)Oc2cc(C)cc(OC(=O)c3ccc(C)cc3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I14 compound treatment 154240.0 75200.0 1.24 160960.0 95300.0 1.52 1.9518 0.995 3019866 ChemDiv3_000190 Brc1ccc2[n+](C/C=C/c3ccccc3)cccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I15 compound treatment 142320.0 63300.0 1.05 125160.0 59500.0 0.95 1.4092 0.9988 2121292 ChemDiv3_000191 Clc1ccc(cc1Cl)S(=O)(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I16 compound treatment 177000.0 98000.0 1.62 144320.0 78600.0 1.25 2.0299 0.992 1483300 ChemDiv3_000192 COc1ccc(Cl)c(NCCC(=O)O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I17 compound treatment 151440.0 72400.0 1.2 130680.0 65000.0 1.04 1.5779 0.9974 1243544 ChemDiv3_000193 CCOc1ccc(cc1OC)C2(CC(=O)Nc3ccccc3)C(=O)c4ccccc4C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I18 compound treatment 138640.0 59600.0 0.98 95320.0 29600.0 0.47 1.03 0.9433 1632789 ChemDiv3_000194 O=C(Nc1cccc2ccccc12)c3cc4ccccc4oc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I19 compound treatment 165200.0 86200.0 1.42 141280.0 75600.0 1.2 1.858 0.9966 1020326 ChemDiv3_000195 CCOC(=O)C1=C(O)c2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I20 compound treatment 144640.0 65600.0 1.08 137040.0 71300.0 1.14 1.5702 0.9997 1160580 ChemDiv3_000196 OC(=O)C(Cc1cnc[nH]1)N2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I21 compound treatment 143200.0 64200.0 1.06 126680.0 61000.0 0.97 1.4366 0.9991 1223725 ChemDiv3_000197 OC(=O)CC1(CC2CC3C1)CC(CC(=O)O)(C2)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I22 compound treatment 141440.0 62400.0 1.03 129280.0 63600.0 1.01 1.4454 1.0 3019868 ChemDiv3_000198 OC(=O)c1ccc(C(=O)O)c(c1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I23 mock treatment 148760.0 69800.0 1.15 78280.0 12600.0 0.2 0.956 0.8179 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 I24 mock treatment 64360.0 -14600.0 -0.24 41240.0 -24500.0 -0.39 -0.4466 -0.9735 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J01 compound treatment 101000.0 22000.0 0.36 32480.0 -33200.0 -0.53 -0.1176 -0.1832 3117610 ChemDiv3_000199 N/N=C(\C(=O)O)/c1ccccc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J02 compound treatment 66120.0 -12900.0 -0.21 43120.0 -22600.0 -0.36 -0.4048 -0.9684 3019869 ChemDiv3_000200 O=C(C[n+]1ccc(C#N)cc1)c2ccc(NC(=O)c3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J03 compound treatment 67440.0 -11600.0 -0.19 38160.0 -27500.0 -0.44 -0.4453 -0.9303 3117612 ChemDiv3_000201 O=C(/C=C/c1c[nH]c2ccccc12)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J04 compound treatment 136960.0 58000.0 0.96 49280.0 -16400.0 -0.26 0.4915 0.4954 1170304 ChemDiv3_000202 OC(=O)CCNc1cc(Cl)ccc1Oc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J05 compound treatment 135440.0 56400.0 0.93 104200.0 38500.0 0.61 1.0927 0.9795 3019870 ChemDiv3_000203 O=C(C[n+]1cccc(NC(=O)c2ccccc2)c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J06 compound treatment 109080.0 30100.0 0.5 89360.0 23700.0 0.38 0.6177 0.9908 1618034 ChemDiv3_000204 COc1ccc(cc1)N2C(=O)C3CC=CC(C)C3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J07 compound treatment 147880.0 68900.0 1.14 148680.0 83000.0 1.32 1.7392 0.9972 3117613 ChemDiv3_000205 CCn1c(C)[n+](CC)c2cc(ccc12)S(=O)(=O)NC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J08 compound treatment 33760.0 -45200.0 -0.75 11400.0 -54300.0 -0.87 -1.14 -0.9973 1082227 ChemDiv3_000206 C(CSc1nc2ccccc2[nH]1)Sc3nc4ccccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J09 compound treatment 205560.0 127000.0 2.09 163640.0 97900.0 1.56 2.581 0.9897 3019871 ChemDiv3_000207 Cc1ccc(cc1C)C(=O)c2ccc(C)c(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J10 compound treatment 160560.0 81600.0 1.35 68960.0 3260.0 0.05 0.9887 0.7338 1921766 ChemDiv3_000208 CC(/N=C/c1ccccc1O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J11 compound treatment 169120.0 90100.0 1.49 119680.0 54000.0 0.86 1.6603 0.9661 1340958 ChemDiv3_000209 CCN(CC)CCSc1nnc2c3ccccc3n(CC(=O)N)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J12 compound treatment 93880.0 14900.0 0.25 87840.0 22100.0 0.35 0.4232 0.9844 1421356 ChemDiv3_000210 O=C(Nc1nc(cs1)c2ccccc2)c3ccc(cc3)S(=O)(=O)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J13 compound treatment 202600.0 124000.0 2.04 182200.0 116000.0 1.86 2.7557 0.9989 3019898 ChemDiv3_000211 Oc1ccccc1/C=N/c2cccc(\N=C\c3ccccc3O)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J14 compound treatment 145000.0 66000.0 1.09 117960.0 52300.0 0.83 1.3593 0.9912 3117614 ChemDiv3_000212 Clc1ccc2[nH]c(=O)nc(c3ccccc3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J15 compound treatment 14800.0 -64200.0 -1.06 11120.0 -54600.0 -0.87 -1.3645 -0.9952 1122932 ChemDiv3_000213 Oc1cc(cc(c1)C2CCCCC2)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J16 compound treatment 179000.0 100000.0 1.65 128640.0 62900.0 1.0 1.8766 0.9715 3117615 ChemDiv3_000214 CC(=O)NC1=NN(C(=O)C)C(C)(CS(=O)(=O)c2ccc(C)cc2)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J17 compound treatment 85920.0 6920.0 0.11 17080.0 -48600.0 -0.78 -0.4672 -0.5964 1730515 ChemDiv3_000215 CNc1ccc2cccc(Oc3ccc4cccc(O)c4n3)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J18 compound treatment 165160.0 86200.0 1.42 134120.0 68400.0 1.09 1.7768 0.9914 1591676 ChemDiv3_000216 Nc1cccc(NC(=O)CCC(=O)O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J19 compound treatment 160000.0 81000.0 1.34 168040.0 102000.0 1.63 2.0988 0.9951 3117616 ChemDiv3_000217 CC1(C)CC(CC(C)(C)N1)/N=C/c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J20 compound treatment 154400.0 75400.0 1.24 137200.0 71500.0 1.14 1.6859 0.999 1528923 ChemDiv3_000218 CC(C)OC(=O)c1cccc(n1)C(=O)OC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J21 compound treatment 173760.0 94800.0 1.56 139800.0 74100.0 1.18 1.9412 0.9904 1320476 ChemDiv3_000219 OC(=O)CC(N1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J22 compound treatment 73080.0 -5920.0 -0.1 44800.0 -20900.0 -0.33 -0.3047 -0.8774 1009844 ChemDiv3_000220 Nc1cc(ccc1O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J23 mock treatment 98680.0 19700.0 0.32 95640.0 29900.0 0.48 0.5671 0.9825 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 J24 mock treatment 96160.0 17200.0 0.28 57880.0 -7830.0 -0.12 0.1122 0.3623 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K01 compound treatment 33080.0 -45900.0 -0.76 24440.0 -41300.0 -0.66 -1.001 -0.9975 1273679 ChemDiv3_000221 CCN(CC)CCOc1ccc2nc(sc2c1)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K02 compound treatment 29400.0 -49600.0 -0.82 17880.0 -47800.0 -0.76 -1.1179 -0.9994 1202625 ChemDiv3_000222 OCCC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K03 compound treatment 100480.0 21500.0 0.35 70880.0 5180.0 0.08 0.3091 0.8489 1450413 ChemDiv3_000223 CS(=O)(=O)CS(=O)(=O)C1=C(C2CCN1CC2)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K04 compound treatment 132920.0 53900.0 0.89 106960.0 41300.0 0.66 1.0944 0.9889 1353143 ChemDiv3_000224 CC(C)N(C(C)C)C(=O)Cn1ccc(=N)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K05 compound treatment 149640.0 70600.0 1.17 100560.0 34900.0 0.56 1.2174 0.9425 3117617 ChemDiv3_000225 CCCCc1ccc(CC(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K06 compound treatment 162280.0 83300.0 1.37 107080.0 41400.0 0.66 1.4384 0.9434 3019901 ChemDiv3_000226 CC[n+]1cccc(c1)c2nc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K07 compound treatment 167840.0 88800.0 1.47 104120.0 38400.0 0.61 1.47 0.9249 1058991 ChemDiv3_000227 CCc1ccc(CC(=S)N2CCOCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K08 compound treatment 152160.0 73200.0 1.21 76360.0 10700.0 0.17 0.9741 0.7987 1049850 ChemDiv3_000228 C(N1CCN(CC1)c2ccccc2)N3CCN(CC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K09 compound treatment 202640.0 124000.0 2.04 102560.0 36900.0 0.59 1.8586 0.8751 1529951 ChemDiv3_000229 COc1ccc2N(C)C(=O)C(C)(CC#N)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K10 compound treatment 210120.0 131000.0 2.16 132840.0 67100.0 1.07 2.2872 0.9472 3117618 ChemDiv3_000230 NC(=O)c1cc[n+](CC(=O)N(CC=C)CC=C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K11 compound treatment 205040.0 126000.0 2.08 153360.0 87700.0 1.4 2.4591 0.9812 1049796 ChemDiv3_000231 C[n+]1ccc(cc1)c2cc[n+](C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K12 compound treatment 180160.0 101000.0 1.67 139720.0 74000.0 1.18 2.015 0.9855 3117619 ChemDiv3_000232 O/N=C/c1ccc[n+](C/C=C/c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K13 compound treatment 106320.0 27300.0 0.45 46520.0 -19200.0 -0.31 0.1027 0.1885 1377603 ChemDiv3_000233 Cc1cccc(NC(=O)c2cccc(c2)C(=O)Nc3cccc(C)c3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K14 compound treatment 181120.0 102000.0 1.69 129960.0 64300.0 1.02 1.9162 0.9715 3117620 ChemDiv3_000234 NC(=O)NC(=O)C[n+]1ccc(/C=N/O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K15 compound treatment 143600.0 64600.0 1.07 131680.0 66000.0 1.05 1.4976 1.0 1086380 ChemDiv3_000235 Brc1ccc(cc1)S(=O)(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K16 compound treatment 178480.0 99500.0 1.64 116880.0 51200.0 0.82 1.738 0.9478 3117621 ChemDiv3_000236 OC(=O)CN(CCc1ccccc1)CC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K17 compound treatment 21000.0 -58000.0 -0.96 7120.0 -58600.0 -0.93 -1.3372 -0.9999 1677145 ChemDiv3_000237 O=C1C(C(C2C(=O)c3ccccc3C2=O)c4ccccc4)C(=O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K18 compound treatment 129760.0 50800.0 0.84 57320.0 -8390.0 -0.13 0.498 0.5869 1190677 ChemDiv3_000238 CCN(CC)c1ccc2cc(C(=O)Nc3ccccc3)c(=N)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K19 compound treatment 187520.0 109000.0 1.79 145960.0 80300.0 1.28 2.1712 0.9864 3019902 ChemDiv3_000239 CCC(=O)c1ccc2cc(OC)ccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K20 compound treatment 158680.0 79700.0 1.32 130800.0 65100.0 1.04 1.6637 0.9931 1231229 ChemDiv3_000240 CCCCC(N1C(=O)c2ccccc2C1=O)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K21 compound treatment 29560.0 -49400.0 -0.82 6440.0 -59300.0 -0.94 -1.245 -0.9973 1111942 ChemDiv3_000241 CN(C)CCC(=O)c1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K22 compound treatment 146800.0 67800.0 1.12 52800.0 -12900.0 -0.21 0.646 0.5677 3019922 ChemDiv3_000242 Cc1cc(NC(=O)c2ccc(N)cc2)c(N)cc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K23 mock treatment 117640.0 38600.0 0.64 100520.0 34800.0 0.55 0.8434 0.9976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 K24 mock treatment 140560.0 61600.0 1.02 37920.0 -27800.0 -0.44 0.4055 0.3658 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L01 compound treatment 88680.0 9680.0 0.16 31200.0 -34500.0 -0.55 -0.2758 -0.4816 3117622 ChemDiv3_000243 CC(=O)Nc1ccc(NC(=O)/C=N/O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L02 compound treatment 49120.0 -29900.0 -0.49 34360.0 -31300.0 -0.5 -0.702 -1.0 3117623 ChemDiv3_000244 O=C(C[n+]1cccc(c1)C(=O)Nc2ccccc2)c3ccc(cc3)N4C(=O)c5ccccc5C4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L03 compound treatment 135120.0 56100.0 0.93 65520.0 -185.0 0.0 0.653 0.7049 3019923 ChemDiv3_000245 CC1(C)CC(CC(C)(C)N1)NC(=O)/C=C/C(=O)NC2CC(C)(C)NC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L04 compound treatment 99480.0 20500.0 0.34 62600.0 -3110.0 -0.05 0.2041 0.5973 1260714 ChemDiv3_000246 CC(C)(C)c1ccc(O)c(CN2CCN(CC2)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L05 compound treatment 130040.0 51000.0 0.84 49960.0 -15700.0 -0.25 0.4184 0.4759 3019924 ChemDiv3_000247 CC(C)N1C(=O)N(C(=CC1(C)C)C)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L06 compound treatment 143840.0 64800.0 1.07 82800.0 17100.0 0.27 0.9495 0.8597 1635573 ChemDiv3_000248 COc1ccc(cc1CN2CCOCC2)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L07 compound treatment 26320.0 -52700.0 -0.87 9920.0 -55800.0 -0.89 -1.2436 -0.9999 1417227 ChemDiv3_000249 C1CN(CCO1)c2ccc(Nc3ccnc4cc5ccccc5cc34)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L08 compound treatment 176640.0 97600.0 1.61 118160.0 52500.0 0.84 1.7309 0.9533 3019925 ChemDiv3_000250 Brc1ccc(cc1)N(CN2C(=O)c3ccccc3C2=O)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L09 compound treatment 189120.0 110000.0 1.82 115000.0 49300.0 0.79 1.841 0.9296 1196316 ChemDiv3_000251 COc1ccc(cc1)C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccnc3OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L10 compound treatment 168960.0 90000.0 1.49 53240.0 -12500.0 -0.2 0.9096 0.6071 1401655 ChemDiv3_000252 CCSC1=C(C#N)C(C(=C(C)N1)C(=O)Nc2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L11 compound treatment 197520.0 119000.0 1.96 122920.0 57200.0 0.91 2.0283 0.9396 1010418 ChemDiv3_000253 Oc1ccc(cc1)S(=O)(=O)c2ccc(O)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L12 compound treatment 197720.0 119000.0 1.96 188480.0 123000.0 1.96 2.7695 1.0 1538510 ChemDiv3_000254 CCOC(=O)n1c(=O)oc2cc(Cl)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L13 compound treatment 130920.0 51900.0 0.86 105160.0 39500.0 0.63 1.0507 0.9884 1642025 ChemDiv3_000255 CCOC(=O)Nc1cc(=O)c2ccccc2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L14 compound treatment 191320.0 112000.0 1.85 135800.0 70100.0 1.12 2.1011 0.9706 1641183 ChemDiv3_000256 O=C(COC(=O)c1cc2ccccc2oc1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L15 compound treatment 166640.0 87600.0 1.45 103960.0 38300.0 0.61 1.4542 0.9262 3019926 ChemDiv3_000257 O/N=C(\c1ccccc1)/C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L16 compound treatment 46840.0 -32200.0 -0.53 8280.0 -57400.0 -0.92 -1.0225 -0.9664 3117624 ChemDiv3_000258 CC[n+]1c(/C=C\2/CC(C)(C)CC(=C2)C)oc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L17 compound treatment 183560.0 105000.0 1.73 24040.0 -41700.0 -0.66 0.7509 0.406 1920076 ChemDiv3_000259 Cc1cc(C)c2ccc(/C=N/O)nc2c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L18 compound treatment 46680.0 -32300.0 -0.53 20840.0 -44900.0 -0.72 -0.8828 -0.9896 3117625 ChemDiv3_000260 CC[n+]1c(/C=C/2\CC(C)CC(=C2)C)sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L19 compound treatment 170600.0 91600.0 1.51 102440.0 36700.0 0.59 1.4832 0.9147 1315100 ChemDiv3_000261 CSc1nc2ccccc2n1CN(C)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L20 compound treatment 158520.0 79500.0 1.31 104600.0 38900.0 0.62 1.3666 0.9413 1305784 ChemDiv3_000262 COC(=O)c1cccc(n1)C(=O)Oc2ccc(OC(=O)c3cccc(n3)C(=O)OC)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L21 compound treatment 10360.0 -68600.0 -1.13 4600.0 -61100.0 -0.97 -1.4898 -0.9972 1433025 ChemDiv3_000263 Cc1cc(cc(C)c1N)C2(CCCCC2)c3cc(C)c(N)c(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L22 compound treatment 129680.0 50700.0 0.84 59400.0 -6310.0 -0.1 0.5205 0.6177 1464584 ChemDiv3_000264 CN(C)c1ccc(cc1)C(O)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L23 mock treatment 120920.0 41900.0 0.69 53920.0 -11800.0 -0.19 0.3565 0.4972 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 L24 mock treatment 117640.0 38600.0 0.64 29840.0 -35900.0 -0.57 0.0469 0.0547 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M01 compound treatment 64040.0 -15000.0 -0.25 38560.0 -27100.0 -0.43 -0.4805 -0.9646 1660133 ChemDiv3_000265 CC1=CC(=O)OC1Cc2ccc3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M02 compound treatment 46960.0 -32000.0 -0.53 38280.0 -27400.0 -0.44 -0.683 -0.9955 1710588 ChemDiv3_000266 CC(=O)Nc1nc(cs1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M03 compound treatment 71800.0 -7200.0 -0.12 51480.0 -14200.0 -0.23 -0.2443 -0.9545 3117626 ChemDiv3_000267 C/N=C\1/S/C(=C\c2cn(CC(=O)O)c3ccccc23)/C(=O)N1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M04 compound treatment 139360.0 60400.0 1.0 96600.0 30900.0 0.49 1.0528 0.9472 3019928 ChemDiv3_000268 CC(C)(C)NC(=O)C[n+]1cccc(/C=N/O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M05 compound treatment 153880.0 74900.0 1.24 64080.0 -1630.0 -0.03 0.8558 0.6921 3117629 ChemDiv3_000269 CC(=O)OC1CCC(CC1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M06 compound treatment 14600.0 -64400.0 -1.06 4920.0 -60800.0 -0.97 -1.4367 -0.9989 3019929 ChemDiv3_000270 CC(=O)Nc1sc2CCCCc2c1SC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M07 compound treatment 164680.0 85700.0 1.41 39600.0 -26100.0 -0.42 0.7059 0.4788 3117630 ChemDiv3_000271 CCC1(CC)C(=[N+](C)c2ccccc21)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M08 compound treatment 186920.0 108000.0 1.78 81800.0 16100.0 0.26 1.4411 0.8007 1692026 ChemDiv3_000272 CC1(C)CC(CC(C)(C)N1)NC(=O)c2ccccc2C(=O)NC3CC(C)(C)NC(C)(C)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M09 compound treatment 95000.0 16000.0 0.26 28080.0 -37600.0 -0.6 -0.2372 -0.362 3019876 ChemDiv3_000273 CC[n+]1c(C)sc(c1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M10 compound treatment 204000.0 125000.0 2.06 72960.0 7260.0 0.12 1.5409 0.7456 3117631 ChemDiv3_000274 NC(=O)c1ccc[n+](CC(=O)N2CCCCC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M11 compound treatment 202400.0 123000.0 2.04 88040.0 22300.0 0.36 1.6921 0.8183 1141301 ChemDiv3_000275 COC(=O)Nc1ccc(cc1)S(=O)(=O)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M12 compound treatment 180760.0 102000.0 1.68 137240.0 71500.0 1.14 1.994 0.9822 3117632 ChemDiv3_000276 O/N=C/c1cc[n+](CCC(=O)NCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M13 compound treatment 100640.0 21600.0 0.36 63600.0 -2110.0 -0.03 0.2289 0.6379 3019878 ChemDiv3_000277 Cc1cccc(NC(=O)/C=C/c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M14 compound treatment 190480.0 111000.0 1.84 112840.0 47100.0 0.75 1.8325 0.9219 3117633 ChemDiv3_000278 OC(=O)c1ccccc1NC(=O)C[n+]2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M15 compound treatment 182000.0 103000.0 1.7 94120.0 28400.0 0.45 1.5225 0.8653 1048436 ChemDiv3_000279 O=C(Nc1ccccc1)C2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M16 compound treatment 186560.0 108000.0 1.78 66560.0 855.0 0.01 1.2652 0.7125 1410422 ChemDiv3_000280 CCNc1c(N)c(=O)oc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M17 compound treatment 169840.0 90800.0 1.5 77560.0 11900.0 0.19 1.194 0.79 3019903 ChemDiv3_000281 Nc1nonc1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M18 compound treatment 145440.0 66400.0 1.1 42680.0 -23000.0 -0.37 0.5161 0.4462 3019904 ChemDiv3_000282 CC(C)C1=CCC(C)/C(=C\c2ccc(Cl)cc2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M19 compound treatment 13400.0 -65600.0 -1.08 4840.0 -60900.0 -0.97 -1.4516 -0.9985 1010017 ChemDiv3_000283 O=C1C=CC(=O)N1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M20 compound treatment 77240.0 -1760.0 -0.03 47000.0 -18700.0 -0.3 -0.2313 -0.7722 1922526 ChemDiv3_000284 Brc1ccccc1c2nc3ccccc3c4nc5ccccc5n24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M21 compound treatment 40480.0 -38500.0 -0.64 23000.0 -42700.0 -0.68 -0.9309 -0.9994 1409537 ChemDiv3_000285 Nc1ccc(cc1)C(=O)CC(=O)Nc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M22 compound treatment 67520.0 -11500.0 -0.19 43360.0 -22300.0 -0.36 -0.3858 -0.9564 1104285 ChemDiv3_000286 OC(=O)c1cc2ccc3cccc4ccc(c1)c2c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M23 mock treatment 127080.0 48100.0 0.79 36160.0 -29500.0 -0.47 0.2283 0.2473 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 M24 mock treatment 102720.0 23700.0 0.39 30760.0 -34900.0 -0.56 -0.1169 -0.1717 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N01 compound treatment 96280.0 17300.0 0.29 25360.0 -40300.0 -0.64 -0.253 -0.3596 3019905 ChemDiv3_000287 C/C(=C/C(=O)O)/C=C/c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N02 compound treatment 61520.0 -17500.0 -0.29 18320.0 -47400.0 -0.76 -0.738 -0.9129 1113098 ChemDiv3_000288 O=C(Oc1ccccc1OC(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N03 compound treatment 179280.0 100000.0 1.66 37800.0 -27900.0 -0.44 0.8561 0.4994 1455237 ChemDiv3_000289 S=C1NCN(CN1)C2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N04 compound treatment 44920.0 -34100.0 -0.56 11880.0 -53800.0 -0.86 -1.0044 -0.9791 1652365 ChemDiv3_000290 CC(C)c1cc(CN2CCN(CC2)c3ccccc3)c(O)c(CN4CCN(CC4)c5ccccc5)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N05 compound treatment 113320.0 34300.0 0.57 18400.0 -47300.0 -0.75 -0.1325 -0.1405 3019907 ChemDiv3_000291 CN(C)C/C(=N/O)/C(=O)Nc1ccc(C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N06 compound treatment 186240.0 107000.0 1.77 53120.0 -12600.0 -0.2 1.11 0.623 1498499 ChemDiv3_000292 COc1cc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)nc(OC)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N07 compound treatment 183680.0 105000.0 1.73 35880.0 -29800.0 -0.48 0.8858 0.4942 1034347 ChemDiv3_000293 N#CCCn1nnc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N08 compound treatment 195880.0 117000.0 1.93 52800.0 -12900.0 -0.21 1.2189 0.6282 3117634 ChemDiv3_000294 CC(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccc4ccccc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N09 compound treatment 190240.0 111000.0 1.84 38480.0 -27200.0 -0.43 0.9916 0.5255 1051930 ChemDiv3_000295 C(c1ccccc1)n2ccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N10 compound treatment 55560.0 -23400.0 -0.39 15320.0 -50400.0 -0.8 -0.8414 -0.9439 1022496 ChemDiv3_000296 OC(=O)CCCc1ccc2ccc3cccc4ccc1c2c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N11 compound treatment 201000.0 122000.0 2.01 64120.0 -1590.0 -0.03 1.4062 0.6982 1579194 ChemDiv3_000297 CN(C)C(=O)c1ccc(Oc2ccc(cc2)C(=O)N(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N12 compound treatment 57680.0 -21300.0 -0.35 22160.0 -43500.0 -0.69 -0.7396 -0.9504 1676465 ChemDiv3_000298 Clc1ccc(cc1)C(=O)n2c(=O)oc3cc(Cl)ccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N13 compound treatment 89560.0 10600.0 0.17 24240.0 -41500.0 -0.66 -0.344 -0.5033 1542255 ChemDiv3_000299 CCOC(=O)c1c(O)cc(C)cc1Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N14 compound treatment 168960.0 90000.0 1.49 84640.0 18900.0 0.3 1.2635 0.8338 3117635 ChemDiv3_000300 O=C(C[n+]1ccccc1)c2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N15 compound treatment 22120.0 -56900.0 -0.94 5280.0 -60400.0 -0.96 -1.3449 -0.9999 1382153 ChemDiv3_000301 O=C1N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N16 compound treatment 49320.0 -29700.0 -0.49 10920.0 -54800.0 -0.87 -0.9638 -0.9627 1667966 ChemDiv3_000302 O=C(Nc1ccc(cc1)c2nc3cc(NC(=O)C4CCCCC4)ccc3o2)C5CCCCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N17 compound treatment 188520.0 110000.0 1.81 30160.0 -35500.0 -0.57 0.8778 0.4633 3019932 ChemDiv3_000303 COC(=O)c1cc2cc(Br)ccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N18 compound treatment 174920.0 95900.0 1.58 25200.0 -40500.0 -0.65 0.6632 0.3878 1508788 ChemDiv3_000304 CC(=O)Nc1ccc2oc3ccccc3c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N19 compound treatment 162880.0 83900.0 1.38 24000.0 -41700.0 -0.66 0.5091 0.3315 3019933 ChemDiv3_000305 NC(=O)CSc1nc2ccccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N20 compound treatment 146920.0 67900.0 1.12 36560.0 -29100.0 -0.46 0.4644 0.3826 1682374 ChemDiv3_000306 COC(=O)c1cccc(n1)C(=O)Nc2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N21 compound treatment 50000.0 -29000.0 -0.48 28160.0 -37500.0 -0.6 -0.7616 -0.9939 1467868 ChemDiv3_000307 Cc1ccc(NC(=O)C2(CC3CC4CC(C3)C2)C4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N22 compound treatment 150040.0 71000.0 1.17 33800.0 -31900.0 -0.51 0.4697 0.3674 3019936 ChemDiv3_000308 O=C/1OC(=N\C1=C/c2ccco2)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N23 mock treatment 109720.0 30700.0 0.51 29760.0 -35900.0 -0.57 -0.0465 -0.0608 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 N24 mock treatment 96120.0 17100.0 0.28 27920.0 -37800.0 -0.6 -0.226 -0.3397 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O01 compound treatment 5680.0 -73300.0 -1.21 2280.0 -63400.0 -1.01 -1.5706 -0.996 3117636 ChemDiv3_000309 NNc1nc(cc(n1)c2ccccc2O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O02 compound treatment 85080.0 6080.0 0.1 21640.0 -44100.0 -0.7 -0.4256 -0.5999 3019937 ChemDiv3_000310 CCCc1[nH]c(Br)nc1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O03 compound treatment 153960.0 75000.0 1.24 36560.0 -29100.0 -0.46 0.5465 0.4135 1573334 ChemDiv3_000311 COc1nsnc1N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O04 compound treatment 178920.0 99900.0 1.65 63880.0 -1830.0 -0.03 1.1458 0.6945 3117637 ChemDiv3_000312 CN(C)C(=O)C[n+]1cccc(/C=N/O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O05 compound treatment 26200.0 -52800.0 -0.87 16680.0 -49000.0 -0.78 -1.1688 -0.9985 1280359 ChemDiv3_000313 CCCCC1CCC(CC1)c2ccc(cc2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O06 compound treatment 176360.0 97400.0 1.61 30360.0 -35300.0 -0.56 0.7381 0.4334 3019939 ChemDiv3_000314 C[n+]1ccccc1c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O07 compound treatment 188920.0 110000.0 1.81 34840.0 -30900.0 -0.49 0.9352 0.4974 1372721 ChemDiv3_000315 CCCCC1CCC(CC1)C(=O)Oc2ccc(OCC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O08 compound treatment 184600.0 106000.0 1.74 26320.0 -39400.0 -0.63 0.7888 0.4257 1559693 ChemDiv3_000316 CCOC(=O)c1[nH]c2ccc(OCC)cc2c1CCCN3C(=O)c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O09 compound treatment 177040.0 98000.0 1.62 37920.0 -27800.0 -0.44 0.8313 0.4954 1672292 ChemDiv3_000317 COC(=O)c1ccc2n(CCO)c(C)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O10 compound treatment 189000.0 110000.0 1.82 63320.0 -2390.0 -0.04 1.2571 0.6922 3117638 ChemDiv3_000318 CC(C)(C)CC[n+]1ccc(cc1)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O11 compound treatment 185600.0 107000.0 1.76 56760.0 -8950.0 -0.14 1.1435 0.6477 3019783 ChemDiv3_000319 CN1C(N(C)c2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O12 compound treatment 128160.0 49200.0 0.81 66600.0 895.0 0.01 0.5839 0.7194 3019784 ChemDiv3_000320 CC(C)(C)CC[n+]1ccc(/C=N/O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O13 compound treatment 141560.0 62600.0 1.03 28920.0 -36800.0 -0.59 0.3157 0.2658 1564111 ChemDiv3_000321 Cc1ccc(cc1)C(=O)c2ccc(Oc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O14 compound treatment 193520.0 115000.0 1.89 70680.0 4980.0 0.08 1.3928 0.7361 1011033 ChemDiv3_000322 Cc1nc(N)c(nc1C)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O15 compound treatment 15920.0 -63100.0 -1.04 4440.0 -61300.0 -0.98 -1.4267 -0.9995 1628748 ChemDiv3_000323 CN(CC(=O)C1=C(C(=O)c2ccccc2C1=O)c3ccc(Br)cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O16 compound treatment 197120.0 118000.0 1.95 56440.0 -9270.0 -0.15 1.2744 0.6517 1540210 ChemDiv3_000324 Nc1c(N2CCOCC2)c3ccccc3oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O17 compound treatment 124960.0 46000.0 0.76 19760.0 -45900.0 -0.73 0.0187 0.0177 1072203 ChemDiv3_000325 CCCn1c2ccccc2c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O18 compound treatment 110960.0 32000.0 0.53 36080.0 -29600.0 -0.47 0.0392 0.0554 3019785 ChemDiv3_000326 COc1ccc(/C=C/2\C(C)CC=C(C(C)C)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O19 compound treatment 200680.0 122000.0 2.01 65360.0 -345.0 -0.01 1.4165 0.7052 1084080 ChemDiv3_000327 CC[n+]1ccc(C)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O20 compound treatment 197320.0 118000.0 1.95 38000.0 -27700.0 -0.44 1.0689 0.5338 1594899 ChemDiv3_000328 COC(=O)CNC(=O)c1cc(OC)c(OC)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O21 compound treatment 79000.0 3.75 0.0 30640.0 -35100.0 -0.56 -0.3951 -0.707 1181132 ChemDiv3_000329 O=C(NCC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O22 compound treatment 164520.0 85500.0 1.41 44680.0 -21000.0 -0.34 0.7613 0.5247 1124218 ChemDiv3_000330 CCc1nc(C)ccc1OCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O23 mock treatment 130480.0 51500.0 0.85 77440.0 11700.0 0.19 0.7332 0.8426 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 O24 mock treatment 136960.0 58000.0 0.96 53640.0 -12100.0 -0.19 0.5406 0.5539 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P01 compound treatment 29640.0 -49400.0 -0.81 43760.0 -21900.0 -0.35 -0.8234 -0.9287 1003174 ChemDiv3_000331 CC(O)c1ccc(Oc2ccc(cc2)C(C)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P02 compound treatment 51800.0 -27200.0 -0.45 49760.0 -15900.0 -0.25 -0.4971 -0.9637 3019787 ChemDiv3_000332 CN(C)c1ccc(/C=N/c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P03 compound treatment 98600.0 19600.0 0.32 37200.0 -28500.0 -0.45 -0.0924 -0.1657 1340347 ChemDiv3_000333 CC(C)(C)c1cc(CN2CCN(CCC#N)CC2)cc(c1O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P04 compound treatment 112080.0 33100.0 0.55 33560.0 -32100.0 -0.51 0.0239 0.0319 3019803 ChemDiv3_000334 COc1cccc2s/c(=N/C(=O)CC3(CC4CC5CC(C4)C3)C5)/n(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P05 compound treatment 32680.0 -46300.0 -0.76 13040.0 -52700.0 -0.84 -1.1342 -0.9989 1922875 ChemDiv3_000335 CCN(CC)C(=O)C1(CC2CC3C1)CC(C2)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P06 compound treatment 141840.0 62800.0 1.04 30360.0 -35300.0 -0.56 0.3352 0.2839 3117639 ChemDiv3_000336 O/N=C/c1cccc[n+]1CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P07 compound treatment 181120.0 102000.0 1.69 26240.0 -39500.0 -0.63 0.7472 0.4153 1035295 ChemDiv3_000337 CC(C)(C)N1C(=O)c2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P08 compound treatment 86120.0 7120.0 0.12 13800.0 -51900.0 -0.83 -0.5018 -0.6006 1005478 ChemDiv3_000338 Nc1ccc(Oc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P09 compound treatment 178960.0 100000.0 1.65 38520.0 -27200.0 -0.43 0.8604 0.5043 1734538 ChemDiv3_000339 OC(=O)CCNC(=O)c1ccco1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P10 compound treatment 30600.0 -48400.0 -0.8 8440.0 -57300.0 -0.91 -1.2103 -0.9978 3117642 ChemDiv3_000340 CN(C)c1ccc(/C=C/2\CCC/C(=C\c3ccccc3)/C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P11 compound treatment 198480.0 119000.0 1.97 48560.0 -17100.0 -0.27 1.2014 0.6034 1511725 ChemDiv3_000341 COC(=O)c1ccc2C(=O)N(C(=O)c2c1)c3cccc(c3)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P12 compound treatment 149720.0 70700.0 1.17 50920.0 -14800.0 -0.24 0.6589 0.5532 1287341 ChemDiv3_000342 O=S(=O)(N1CCOCC1)c2cccc(c2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P13 compound treatment 56640.0 -22400.0 -0.37 26760.0 -38900.0 -0.62 -0.6999 -0.9692 1166133 ChemDiv3_000343 CN(C)CCOC(=O)c1ccc2n(CCN(C)C)c(C)c(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P14 compound treatment 151920.0 72900.0 1.2 66880.0 1180.0 0.02 0.8644 0.718 1920545 ChemDiv3_000344 O=c1cc([nH]c(=S)[nH]1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P15 compound treatment 145360.0 66400.0 1.1 26880.0 -38800.0 -0.62 0.3371 0.2679 3117643 ChemDiv3_000345 Oc1ccc(Br)cc1/C=N\CC2(CC3CC4CC(C3)CC2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P16 compound treatment 87760.0 8760.0 0.14 33800.0 -31900.0 -0.51 -0.2573 -0.4866 1350693 ChemDiv3_000346 Nc1ccc(CCc2nc3ccccc3[nH]2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P17 compound treatment 172520.0 93500.0 1.54 49840.0 -15900.0 -0.25 0.9128 0.5835 1509469 ChemDiv3_000347 CCN(CC)C(=O)c1cc(nc2ccccc12)c3cc(C(=O)N(CC)CC)c4ccccc4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P18 compound treatment 185280.0 106000.0 1.75 35440.0 -30300.0 -0.48 0.8995 0.4943 3019852 ChemDiv3_000348 O/N=C(\Cn1cncn1)/c2ccc(Cl)cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P19 compound treatment 251960.0 173000.0 2.86 61160.0 -4550.0 -0.07 1.9677 0.6889 1127886 ChemDiv3_000349 C(Cc1nc2ccccc2o1)Cc3nc4ccccc4o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P20 compound treatment 96040.0 17000.0 0.28 33080.0 -32600.0 -0.52 -0.1687 -0.2854 1524725 ChemDiv3_000350 COC(=O)c1cccc(n1)C(=O)Nc2cnc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P21 compound treatment 21320.0 -57700.0 -0.95 5360.0 -60300.0 -0.96 -1.3533 -1.0 1740437 ChemDiv3_000351 OC(CNCc1ccccc1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P22 compound treatment 75120.0 -3880.0 -0.06 54800.0 -10900.0 -0.17 -0.1681 -0.9079 3019853 ChemDiv3_000352 Brc1ccc(cc1)S(=O)(=O)/N=C(\Oc2ccccc2)/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P23 mock treatment 68600.0 -10400.0 -0.17 60400.0 -5310.0 -0.08 -0.1811 -0.9468 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2001 P24 mock treatment 48520.0 -30500.0 -0.5 55600.0 -10100.0 -0.16 -0.4696 -0.889 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A01 compound treatment 45640.0 -38800.0 -0.64 53240.0 -30000.0 -0.48 -0.7908 -0.9897 3117644 ChemDiv3_000353 Brc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A02 compound treatment 2680.0 -81700.0 -1.35 3040.0 -80200.0 -1.28 -1.858 -0.9996 1625003 ChemDiv3_000354 NS(=O)(=O)c1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A03 compound treatment 31560.0 -52900.0 -0.87 29600.0 -53600.0 -0.86 -1.2216 -0.9999 1914243 ChemDiv3_000355 O=C(Oc1ccc2ccccc2c1)/C=C/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A04 compound treatment 49680.0 -34700.0 -0.57 67320.0 -15900.0 -0.25 -0.5849 -0.9328 1922486 ChemDiv3_000356 O=C/1NC(=S)S\C1=C\Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A05 compound treatment 2560.0 -81900.0 -1.35 3120.0 -80100.0 -1.28 -1.8585 -0.9996 1148913 ChemDiv3_000357 CC(C)(C)NC(=O)c1ccc2C(=O)c3ccccc3-c4onc1c42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A06 compound treatment 17960.0 -66500.0 -1.1 23280.0 -60000.0 -0.96 -1.4515 -0.9976 1082370 ChemDiv3_000358 NCCSC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A07 compound treatment 29520.0 -54900.0 -0.91 36240.0 -47000.0 -0.75 -1.1705 -0.9955 1561720 ChemDiv3_000359 Cc1ccc2nc(cc(C(=O)Nc3ccccc3)c2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A08 compound treatment 45120.0 -39300.0 -0.65 33120.0 -50100.0 -0.8 -1.0236 -0.9947 1739494 ChemDiv3_000360 CC(=O)Nc1c(N)c2ccccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A09 compound treatment 4000.0 -80400.0 -1.33 2800.0 -80400.0 -1.28 -1.8453 -0.9998 1726014 ChemDiv3_000361 C(CN1CCN(CC1)C(c2ccccc2)c3ccccc3)Cc4c[nH]c5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A10 compound treatment 36720.0 -47700.0 -0.79 31240.0 -52000.0 -0.83 -1.1429 -0.9997 1003179 ChemDiv3_000362 COc1ccc(cc1)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A11 compound treatment 65520.0 -18900.0 -0.31 50840.0 -32400.0 -0.52 -0.5858 -0.9708 1574213 ChemDiv3_000363 COc1ccc(cc1)S(=O)(=O)NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A12 compound treatment 100240.0 15800.0 0.26 101520.0 18300.0 0.29 0.3906 0.9985 3117645 ChemDiv3_000364 COc1ccc(/C=N/c2ccc(cc2)C(=O)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A13 compound treatment 117760.0 33300.0 0.55 68280.0 -15000.0 -0.24 0.2205 0.3676 3019887 ChemDiv3_000365 O/N=C(/c1ccccc1)\c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A14 compound treatment 76720.0 -7700.0 -0.13 63480.0 -19800.0 -0.32 -0.3126 -0.9203 1478079 ChemDiv3_000366 Fc1ccc(NC(=O)c2cc3ccccc3oc2=N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A15 compound treatment 42960.0 -41500.0 -0.68 50800.0 -32400.0 -0.52 -0.8496 -0.9905 3117646 ChemDiv3_000367 Cn1c2ccc(/N=C/c3ccccc3O)cc2c4nc5ccccc5nc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A16 compound treatment 37960.0 -46500.0 -0.77 32480.0 -50800.0 -0.81 -1.1144 -0.9996 1190781 ChemDiv3_000368 Cc1c(N=c2c(=O)c3ccccc3c2=O)c(=O)n(c4ccccc4)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A17 compound treatment 12680.0 -71700.0 -1.18 5880.0 -77400.0 -1.23 -1.7093 -0.9998 3019890 ChemDiv3_000369 CCOC(=O)n1c(=S)oc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A18 compound treatment 36320.0 -48100.0 -0.79 29240.0 -54000.0 -0.86 -1.1701 -0.9992 1644186 ChemDiv3_000370 CCOC(=O)COc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A19 compound treatment 48040.0 -36400.0 -0.6 51840.0 -31400.0 -0.5 -0.7786 -0.9959 3117647 ChemDiv3_000371 COc1cccc(/C=N/c2cccc(NC(=O)c3ccc(F)cc3)c2)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A20 compound treatment 6600.0 -77800.0 -1.28 9800.0 -73400.0 -1.17 -1.7361 -0.9989 1428551 ChemDiv3_000372 CCCC1(CCC2(CC1)c3ccc(C#N)cc3)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A21 compound treatment 39200.0 -45200.0 -0.75 39960.0 -43300.0 -0.69 -1.0156 -0.9992 3019912 ChemDiv3_000373 CC(C(=O)c1ccccc1)[n+]2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A22 compound treatment 29200.0 -55200.0 -0.91 25760.0 -57500.0 -0.92 -1.2924 -1.0 3117648 ChemDiv3_000374 Cc1cccc(NC(=O)CN2C(=O)/C(=N\N)/c3ccccc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A23 mock treatment 49200.0 -35200.0 -0.58 55240.0 -28000.0 -0.45 -0.7267 -0.9915 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 A24 mock treatment 98240.0 13800.0 0.23 48400.0 -34800.0 -0.56 -0.2314 -0.3853 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B01 compound treatment 47080.0 -37300.0 -0.62 53360.0 -29900.0 -0.48 -0.7726 -0.9919 3117649 ChemDiv3_000375 CCOC(=O)c1ccc(/N=C/c2ccc3OCOc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B02 compound treatment 55840.0 -28600.0 -0.47 71440.0 -11800.0 -0.19 -0.4666 -0.9188 1617961 ChemDiv3_000376 CC(C)OC(=O)CN1C(=O)c2ccc(cc2C1=O)C(=O)OC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B03 compound treatment 67480.0 -16900.0 -0.28 72120.0 -11100.0 -0.18 -0.3231 -0.9759 1656957 ChemDiv3_000377 CC1(CN2CN3C1)C(=O)C(C2)(C3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B04 compound treatment 18920.0 -65500.0 -1.08 20680.0 -62600.0 -1.0 -1.4696 -0.9992 3117650 ChemDiv3_000378 COc1ccc(/C=C/2\C(C)CCC(C)(C(C)C)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B05 compound treatment 65280.0 -19100.0 -0.32 67200.0 -16000.0 -0.26 -0.4042 -0.9945 1688345 ChemDiv3_000379 Oc1nc2SCCCn2c(=O)c1Cc3cc(Cl)cc(Cl)c3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B06 compound treatment 22360.0 -62100.0 -1.02 17200.0 -66000.0 -1.05 -1.4687 -0.9999 3020471 ChemDiv3_000380 COc1ccc(cc1)c2c(C)s/c(=N\c3ccc(C)cc3)/n2CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B07 compound treatment 10960.0 -73500.0 -1.21 16800.0 -66400.0 -1.06 -1.6063 -0.9977 1735047 ChemDiv3_000381 CC(=O)Oc1ccc(cc1)N(C(=O)C)S(=O)(=O)c2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B08 compound treatment 33160.0 -51300.0 -0.85 31080.0 -52200.0 -0.83 -1.1862 -1.0 3020472 ChemDiv3_000382 COc1ccc(/N=C/c2cn(nc2c3ccccc3)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B09 compound treatment 39640.0 -44800.0 -0.74 50600.0 -32600.0 -0.52 -0.8906 -0.9852 3020473 ChemDiv3_000383 CN(C)c1ccc(/C=N/c2cc(Br)c3OCCOc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B10 compound treatment 13760.0 -70700.0 -1.17 11800.0 -71400.0 -1.14 -1.6299 -0.9999 3020474 ChemDiv3_000384 O=C1NC(=O)C(=Cc2ccc(o2)c3ccccc3)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B11 compound treatment 67640.0 -16800.0 -0.28 66160.0 -17100.0 -0.27 -0.3884 -1.0 3117651 ChemDiv3_000385 C(CSc1nc2ccccc2n1CCOc3ccccc3)Oc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B12 compound treatment 122800.0 38400.0 0.63 113520.0 30300.0 0.48 0.7892 0.991 3020475 ChemDiv3_000386 Clc1ccc(/C=C/2\SC(=S)N(CCC(=O)Nc3ccccc3)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B13 compound treatment 114720.0 30300.0 0.5 113840.0 30600.0 0.49 0.6985 0.9999 3117652 ChemDiv3_000387 CN1/C(=C\2/SC(=S)N(C2=O)c3ccccc3)/Sc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B14 compound treatment 65720.0 -18700.0 -0.31 59440.0 -23800.0 -0.38 -0.4865 -0.9948 1709090 ChemDiv3_000388 CC(C)(C)NC(=S)NC(=O)C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B15 compound treatment 81720.0 -2700.0 -0.04 85560.0 2320.0 0.04 -0.0054 -0.0933 1222580 ChemDiv3_000389 C(n1ccc2ccccc12)C3(OCCO3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B16 compound treatment 45760.0 -38700.0 -0.64 54320.0 -28900.0 -0.46 -0.7772 -0.9873 3020476 ChemDiv3_000390 Cn1c[n+](C)cc1C(O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B17 compound treatment 39800.0 -44600.0 -0.74 27240.0 -56000.0 -0.89 -1.152 -0.9954 3117653 ChemDiv3_000391 C(=N/c1ccc2ccccc2c1)\c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B18 compound treatment 22680.0 -61700.0 -1.02 16400.0 -66800.0 -1.07 -1.474 -0.9998 3117654 ChemDiv3_000392 CC1(C)Cc2ccccc2/C(=N/c3nc(cs3)c4ccccc4)/N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B19 compound treatment 38520.0 -45900.0 -0.76 57280.0 -26000.0 -0.41 -0.8284 -0.9595 1338386 ChemDiv3_000393 CCC1(CC2CC3(O)CC(O)(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B20 compound treatment 4640.0 -79800.0 -1.32 3400.0 -79800.0 -1.27 -1.8311 -0.9999 1917487 ChemDiv3_000394 CC(/N=C/c1c(O)ccc2ccccc12)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B21 compound treatment 19160.0 -65300.0 -1.08 21200.0 -62000.0 -0.99 -1.461 -0.9991 3117655 ChemDiv3_000395 S=C/1OC(=C\C1=C/N2CCCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B22 compound treatment 31960.0 -52500.0 -0.87 35760.0 -47500.0 -0.76 -1.1475 -0.9977 3020477 ChemDiv3_000396 Cc1c(/N=C/2\SCC(=O)N2/N=C\c3ccc(Br)cc3)c(=O)n(c4ccccc4)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B23 mock treatment 42480.0 -41900.0 -0.69 69760.0 -13500.0 -0.21 -0.6415 -0.885 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 B24 mock treatment 74280.0 -10100.0 -0.17 57360.0 -25900.0 -0.41 -0.4101 -0.921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C01 compound treatment 43760.0 -40700.0 -0.67 51320.0 -31900.0 -0.51 -0.8344 -0.9907 3117656 ChemDiv3_000397 O/N=C\1/C(=O)N(CC(=O)Nc2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C02 compound treatment 11520.0 -72900.0 -1.2 15680.0 -67600.0 -1.08 -1.6124 -0.9985 1329935 ChemDiv3_000398 O=C1N(CCC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C03 compound treatment 45880.0 -38500.0 -0.64 43640.0 -39600.0 -0.63 -0.8962 -1.0 3020478 ChemDiv3_000399 Cc1cc(=O)oc(C)c1C(=O)OCC(=O)c2ccc(Cl)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C04 compound treatment 94040.0 9620.0 0.16 80880.0 -2370.0 -0.04 0.0857 0.5247 3117657 ChemDiv3_000400 Cc1cc(C)c2nc(NC(=O)c3ccc(C#N)cc3)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C05 compound treatment 53480.0 -30900.0 -0.51 43680.0 -39600.0 -0.63 -0.807 -0.9945 1721945 ChemDiv3_000401 Cc1ccc2c(=O)c(coc2c1)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C06 compound treatment 93400.0 8980.0 0.15 98760.0 15500.0 0.25 0.2797 0.9701 1169311 ChemDiv3_000402 OC(=O)CSC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C07 compound treatment 33040.0 -51400.0 -0.85 32640.0 -50600.0 -0.81 -1.17 -0.9997 3117658 ChemDiv3_000403 COc1ccc(/C=C/2\CCCC3=C2NC(=S)NC3c4ccc(OC)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C08 compound treatment 29600.0 -54800.0 -0.9 38840.0 -44400.0 -0.71 -1.1403 -0.9926 1345307 ChemDiv3_000404 Cc1cc2nc(SCCN3CCCC3)[nH]c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C09 compound treatment 33880.0 -50500.0 -0.83 34840.0 -48400.0 -0.77 -1.1354 -0.9992 3117659 ChemDiv3_000405 Cc1sc(/N=C/c2ccccc2O)c(C#N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C10 compound treatment 59520.0 -24900.0 -0.41 66240.0 -17000.0 -0.27 -0.4823 -0.9796 1625198 ChemDiv3_000406 COc1ccc(cc1OC)c2cnn(c2N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C11 compound treatment 47160.0 -37300.0 -0.62 52320.0 -30900.0 -0.49 -0.7834 -0.994 1460903 ChemDiv3_000407 Cc1ccc(NS(=O)(=O)c2cccc(c2)C(=O)Nc3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C12 compound treatment 98160.0 13700.0 0.23 76480.0 -6770.0 -0.11 0.0842 0.3351 3020479 ChemDiv3_000408 Fc1ccccc1/C=N/c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C13 compound treatment 128160.0 43700.0 0.72 135520.0 52300.0 0.83 1.0997 0.9975 1489098 ChemDiv3_000409 CN1C2CCC1CC(C2)OC(=O)CCN3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C14 compound treatment 74000.0 -10400.0 -0.17 78160.0 -5090.0 -0.08 -0.1789 -0.9411 3117660 ChemDiv3_000410 CC(=O)NC1C(O)C(O)C(CO)OC1OCCOc2ccc(Cl)cc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C15 compound treatment 44640.0 -39800.0 -0.66 46440.0 -36800.0 -0.59 -0.8791 -0.9984 3020480 ChemDiv3_000411 Fc1ccccc1/C=C\2/SC(=O)N(CN3CCCCC3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C16 compound treatment 30920.0 -53500.0 -0.88 29640.0 -53600.0 -0.85 -1.2286 -0.9999 3117661 ChemDiv3_000412 Cc1cs/c(=N\c2ccccc2)/n1CC(=O)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C17 compound treatment 44360.0 -40100.0 -0.66 49680.0 -33600.0 -0.53 -0.8459 -0.9945 1338722 ChemDiv3_000413 O=c1oc2ccccc2n1CNc3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C18 compound treatment 27520.0 -56900.0 -0.94 37120.0 -46100.0 -0.74 -1.184 -0.9927 3117662 ChemDiv3_000414 CCOc1ccc(cc1)[n+]2c(cn3CCCc32)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C19 compound treatment 49760.0 -34700.0 -0.57 76720.0 -6530.0 -0.1 -0.4781 -0.8222 3117663 ChemDiv3_000415 CC(C)C1(C)N=C(NC1=O)c2ncccc2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C20 compound treatment 38880.0 -45500.0 -0.75 49800.0 -33400.0 -0.53 -0.9085 -0.9858 3020481 ChemDiv3_000416 CC(=C)C(=O)Nc1ccc(O)c(c1)c2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C21 compound treatment 51200.0 -33200.0 -0.55 39880.0 -43400.0 -0.69 -0.8765 -0.9934 3117664 ChemDiv3_000417 CC(C(=O)c1ccccc1)[n+]2cccc(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C22 compound treatment 39880.0 -44500.0 -0.74 61800.0 -21400.0 -0.34 -0.7615 -0.9393 3020482 ChemDiv3_000418 N/C(=N\O)/C[n+]1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C23 mock treatment 41680.0 -42700.0 -0.71 61680.0 -21600.0 -0.34 -0.7419 -0.9454 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 C24 mock treatment 50400.0 -34000.0 -0.56 66000.0 -17200.0 -0.27 -0.5914 -0.946 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D01 compound treatment 39680.0 -44700.0 -0.74 54800.0 -28400.0 -0.45 -0.8428 -0.9726 3117665 ChemDiv3_000419 Brc1ccc(/C=N\C2C3CC4CC(C3)CC2C4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D02 compound treatment 55520.0 -28900.0 -0.48 54560.0 -28700.0 -0.46 -0.6606 -0.9998 1642252 ChemDiv3_000420 CC(C(CC(=O)O)C(=O)O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D03 compound treatment 23600.0 -60800.0 -1.0 18600.0 -64600.0 -1.03 -1.4384 -0.9999 1348263 ChemDiv3_000421 CC(C)Oc1ccc2c(C)c(Cc3ccccc3)c(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D04 compound treatment 95480.0 11100.0 0.18 101080.0 17800.0 0.28 0.3301 0.9771 1509351 ChemDiv3_000422 COc1ccc(cc1OC)C(=O)Nc2ccc3C(=O)N(C)C(=O)c3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D05 compound treatment 10760.0 -73700.0 -1.22 12240.0 -71000.0 -1.13 -1.66 -0.9994 3020483 ChemDiv3_000423 CCN1C(=O)C(=Cc2ccc(cc2)N(C)C)C(=O)N(CC)C1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D06 compound treatment 57120.0 -27300.0 -0.45 64480.0 -18800.0 -0.3 -0.5301 -0.9802 3117666 ChemDiv3_000424 CCOC(=O)C1=C(C)NC(=S)NC1c2ccc(o2)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D07 compound treatment 20920.0 -63500.0 -1.05 40000.0 -43200.0 -0.69 -1.2285 -0.9793 1529711 ChemDiv3_000425 Oc1cc2ccccc2cc1C(=O)Nc3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D08 compound treatment 4120.0 -80300.0 -1.33 4320.0 -78900.0 -1.26 -1.8268 -0.9997 3117667 ChemDiv3_000426 CN(C)c1ccc(cc1)c2cccc([o+]2)c3ccc(cc3)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D09 compound treatment 55160.0 -29300.0 -0.48 72840.0 -10400.0 -0.17 -0.4588 -0.8984 3020484 ChemDiv3_000427 Nc1nc2ccc(cc2s1)c3nc4ccccc4o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D10 compound treatment 6360.0 -78100.0 -1.29 10040.0 -73200.0 -1.17 -1.7362 -0.9988 3117668 ChemDiv3_000428 Cn1c(c(/C=C\2/C(=O)Oc3ccccc3C2=O)c4ccccc14)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D11 compound treatment 85680.0 1260.0 0.02 83160.0 -85.0 0.0 0.0138 0.6597 3020485 ChemDiv3_000429 CCC1SC2=NCN(CN2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D12 compound treatment 124400.0 40000.0 0.66 133560.0 50300.0 0.8 1.0338 0.9953 1918348 ChemDiv3_000430 COc1ccc(/C=C/2\SC(=S)N(CC(=O)Nc3ccccc3)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D13 compound treatment 137600.0 53200.0 0.88 136920.0 53700.0 0.86 1.2257 0.9999 3117669 ChemDiv3_000431 CCN1/C(=C\2/SC(=S)NC2=O)/Sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D14 compound treatment 39680.0 -44700.0 -0.74 41280.0 -42000.0 -0.67 -0.9951 -0.9988 1556840 ChemDiv3_000432 Cc1ccc(NC(=S)NC(=O)C2(CC3CC4C2)CC(C3)CC4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D15 compound treatment 59480.0 -24900.0 -0.41 78000.0 -5250.0 -0.08 -0.3502 -0.8337 1257795 ChemDiv3_000433 O=C1CSC(N1CCc2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D16 compound treatment 100880.0 16500.0 0.27 81880.0 -1370.0 -0.02 0.1768 0.6484 3020486 ChemDiv3_000434 C[n+]1cc(ccc1/C=N/O)C(=O)NCCC[N+]2(C)CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D17 compound treatment 8800.0 -75600.0 -1.25 6280.0 -77000.0 -1.23 -1.75 -1.0 1486295 ChemDiv3_000435 C1CCc2c(C1)c(nc3ccc4ccccc4c23)c5cccnc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D18 compound treatment 47280.0 -37100.0 -0.61 39960.0 -43300.0 -0.69 -0.9213 -0.9983 3117670 ChemDiv3_000436 Cc1cc2CC(C)(C)N/C(=N\c3ccccc3)/c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D19 compound treatment 98720.0 14300.0 0.24 83920.0 675.0 0.01 0.1746 0.7386 1377733 ChemDiv3_000437 OC(=O)C1(CC2CC3C1)CC(C2)C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D20 compound treatment 45600.0 -38800.0 -0.64 58440.0 -24800.0 -0.4 -0.7327 -0.9731 1712241 ChemDiv3_000438 CCOc1ccc(Nc2nc3cc(C)ccc3cc2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D21 compound treatment 12280.0 -72100.0 -1.19 13800.0 -69400.0 -1.11 -1.6247 -0.9993 3020487 ChemDiv3_000439 N/C=C/1\C=C(OC1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D22 compound treatment 20840.0 -63600.0 -1.05 15840.0 -67400.0 -1.07 -1.5018 -0.9999 3117671 ChemDiv3_000440 Cc1cccc(Nc2nc3ccccn3c(=O)c2/C=N/c4cccc(C)c4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D23 mock treatment 53160.0 -31300.0 -0.52 49760.0 -33500.0 -0.53 -0.7422 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 D24 mock treatment 41880.0 -42500.0 -0.7 46800.0 -36400.0 -0.58 -0.9073 -0.9956 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E01 compound treatment 32800.0 -51600.0 -0.85 27800.0 -55400.0 -0.88 -1.2274 -0.9998 3020488 ChemDiv3_000441 O=C/1NC(=S)N\C1=C/c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E02 compound treatment 3800.0 -80600.0 -1.33 3720.0 -79500.0 -1.27 -1.8373 -0.9997 1159657 ChemDiv3_000442 CC1SC(=NC1(O)C2(CC3CC4CC(C3)C2)C4)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E03 compound treatment 37320.0 -47100.0 -0.78 37720.0 -45500.0 -0.73 -1.0628 -0.9994 1407431 ChemDiv3_000443 Cc1ccc(NC(=O)c2cccc(Oc3ccc(C#N)cc3)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E04 compound treatment 90560.0 6140.0 0.1 85760.0 2520.0 0.04 0.1 0.9176 1509204 ChemDiv3_000444 COC(=O)C(C)Nc1cccc(Br)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E05 compound treatment 8200.0 -76200.0 -1.26 6320.0 -76900.0 -1.23 -1.7566 -0.9999 3117672 ChemDiv3_000445 O=C(/C=C/c1ccco1)/C=C/c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E06 compound treatment 111760.0 27300.0 0.45 115640.0 32400.0 0.52 0.6843 0.9978 1168228 ChemDiv3_000446 CNC1(CC2CC3CC(S)(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E07 compound treatment 38600.0 -45800.0 -0.76 44840.0 -38400.0 -0.61 -0.9676 -0.9945 3117673 ChemDiv3_000447 OC(=O)CCC(=O)N1N=C/2C(CCC\C2=C/c3ccc(F)cc3)C1c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E08 compound treatment 6840.0 -77600.0 -1.28 6160.0 -77100.0 -1.23 -1.7743 -0.9998 1139169 ChemDiv3_000448 C1CCN(CC1)Sc2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E09 compound treatment 51400.0 -33000.0 -0.55 35920.0 -47300.0 -0.75 -0.9188 -0.9873 1916119 ChemDiv3_000449 Brc1ccc(cc1)C(=O)COC(=O)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E10 compound treatment 51280.0 -33100.0 -0.55 57600.0 -25600.0 -0.41 -0.6758 -0.9897 3020489 ChemDiv3_000450 Oc1ccc(Br)cc1/C=N/c2cc3OCCOc3cc2Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E11 compound treatment 82560.0 -1860.0 -0.03 71560.0 -11700.0 -0.19 -0.1534 -0.8126 3117674 ChemDiv3_000451 NC(=S)NC(=O)/C=C/c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E12 compound treatment 100880.0 16500.0 0.27 97920.0 14700.0 0.23 0.3575 0.9972 3020490 ChemDiv3_000452 Fc1ccc(/N=C/c2ccccc2F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E13 compound treatment 144240.0 59800.0 0.99 141840.0 58600.0 0.93 1.3586 0.9996 1516214 ChemDiv3_000453 CN(Cc1ccccc1)C(=O)CN2CCCC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E14 compound treatment 100440.0 16000.0 0.26 133200.0 50000.0 0.8 0.75 0.894 1022614 ChemDiv3_000454 OCCNC(=O)COc1ccc(Cl)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E15 compound treatment 112240.0 27800.0 0.46 116680.0 33400.0 0.53 0.7016 0.9973 3117675 ChemDiv3_000455 Cc1ccc(cc1)c2cs/c(=N/C(=O)Nc3ccccc3)/[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E16 compound treatment 42040.0 -42400.0 -0.7 42640.0 -40600.0 -0.65 -0.9523 -0.9992 3020491 ChemDiv3_000456 Clc1ccc(cc1Cl)c2cnc3CCCn23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E17 compound treatment 105720.0 21300.0 0.35 77080.0 -6170.0 -0.1 0.1792 0.4907 3117676 ChemDiv3_000457 CCSc1nnc(NC(=O)/C=C/c2ccccc2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E18 compound treatment 62360.0 -22100.0 -0.36 73680.0 -9570.0 -0.15 -0.3653 -0.9253 1523604 ChemDiv3_000458 CC(C)C1CCC(C)CC1OCC(O)C[N+]2(C)CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E19 compound treatment 22880.0 -61500.0 -1.02 28600.0 -54600.0 -0.87 -1.3342 -0.9971 3020492 ChemDiv3_000459 O=C(/C=C\1/Nc2ccccc2NC1=O)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E20 compound treatment 8600.0 -75800.0 -1.25 10000.0 -73200.0 -1.17 -1.7105 -0.9994 3117677 ChemDiv3_000460 c1ccc2[nH]c(nc2c1)c3nc4ccccc4s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E21 compound treatment 68720.0 -15700.0 -0.26 57160.0 -26100.0 -0.42 -0.4772 -0.9741 3020493 ChemDiv3_000461 O=C1N(C(=O)C(=Cc2ccccc2)C(=O)N1c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E22 compound treatment 54640.0 -29800.0 -0.49 78080.0 -5170.0 -0.08 -0.4058 -0.8142 1013141 ChemDiv3_000462 C[n+]1cccc(c1)C(=O)NO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E23 mock treatment 64000.0 -20400.0 -0.34 74440.0 -8810.0 -0.14 -0.3376 -0.9246 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 E24 mock treatment 46760.0 -37700.0 -0.62 33560.0 -49700.0 -0.79 -0.9995 -0.9928 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F01 compound treatment 14760.0 -69700.0 -1.15 24120.0 -59100.0 -0.94 -1.4794 -0.9951 1512742 ChemDiv3_000463 CN(C)CCNC(=O)C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F02 compound treatment 41680.0 -42700.0 -0.71 39640.0 -43600.0 -0.69 -0.9903 -1.0 1734477 ChemDiv3_000464 O=c1n(Cc2ccccc2)c3ccccc3n1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F03 compound treatment 29520.0 -54900.0 -0.91 20520.0 -62700.0 -1.0 -1.3477 -0.9988 3117678 ChemDiv3_000465 CCN(CC)C(=S)Sc1ncnc2sc3CCCCc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F04 compound treatment 96200.0 11800.0 0.19 93760.0 10500.0 0.17 0.256 0.9973 3020494 ChemDiv3_000466 COC(=O)C1=C(C)N(Cc2ccccc2)C(=O)NC1c3ccccc3F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F05 compound treatment 5520.0 -78900.0 -1.3 6120.0 -77100.0 -1.23 -1.7901 -0.9996 3020545 ChemDiv3_000467 C=CCN1C(=O)NC(=O)/C(=C/c2ccco2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F06 compound treatment 60560.0 -23900.0 -0.39 77520.0 -5730.0 -0.09 -0.343 -0.8485 1529101 ChemDiv3_000468 Clc1ccc(NC(NC(=O)c2ccccc2)C(=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F07 compound treatment 6720.0 -77700.0 -1.28 7200.0 -76000.0 -1.21 -1.764 -0.9996 1408295 ChemDiv3_000469 Clc1ccc(OCC(=O)CC(=O)c2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F08 compound treatment 69040.0 -15400.0 -0.25 98960.0 15700.0 0.25 -0.0024 -0.0067 1428920 ChemDiv3_000470 Cc1cc(C)c(OCC(O)CNC(C)(C)C)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F09 compound treatment 42120.0 -42300.0 -0.7 55360.0 -27900.0 -0.44 -0.808 -0.9762 1291361 ChemDiv3_000471 Nc1ccc(cc1)C(=O)OCc2nc3cc4ccccc4cc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F10 compound treatment 75080.0 -9340.0 -0.15 66040.0 -17200.0 -0.27 -0.3029 -0.9629 1234670 ChemDiv3_000472 CCOC(=O)c1oc2ccccc2c1CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F11 compound treatment 99560.0 15100.0 0.25 91440.0 8200.0 0.13 0.2691 0.9542 1627155 ChemDiv3_000473 CN1C(=O)C(O)N(C1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F12 compound treatment 128120.0 43700.0 0.72 130400.0 47200.0 0.75 1.0416 0.9998 3020546 ChemDiv3_000474 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F13 compound treatment 101600.0 17200.0 0.28 120960.0 37700.0 0.6 0.6256 0.9412 3117679 ChemDiv3_000475 CCN1/C(=C\2/SC(=S)N(CC=C)C2=O)/Sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F14 compound treatment 29360.0 -55100.0 -0.91 77040.0 -6210.0 -0.1 -0.7126 -0.7795 3117681 ChemDiv3_000476 Cc1ccc(cc1)C2(CC3CC4CC(C3)(C2)C(=O)NC5=NCCS5)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F15 compound treatment 104640.0 20200.0 0.33 88280.0 5040.0 0.08 0.2928 0.8528 1673178 ChemDiv3_000477 COc1cc(cc(OC)c1OC)C2SC(C)C(=O)N2CCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F16 compound treatment 7520.0 -76900.0 -1.27 8040.0 -75200.0 -1.2 -1.7452 -0.9996 3117682 ChemDiv3_000478 COC(=O)/C=C/S(=O)(=O)c1ccc(NC(=O)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F17 compound treatment 37840.0 -46600.0 -0.77 42400.0 -40800.0 -0.65 -1.004 -0.9966 1500308 ChemDiv3_000479 Cc1ccc2c(=O)cc(oc2c1)c3ccc(F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F18 compound treatment 71320.0 -13100.0 -0.22 88440.0 5200.0 0.08 -0.0943 -0.4074 3020547 ChemDiv3_000480 CC(=C1C(=NN(C1=O)c2ccccc2)C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F19 compound treatment 126280.0 41900.0 0.69 145920.0 62700.0 1.0 1.195 0.9838 1047176 ChemDiv3_000481 CCOC(=O)c1cc[nH]c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F20 compound treatment 107360.0 22900.0 0.38 118920.0 35700.0 0.57 0.6699 0.9805 3117683 ChemDiv3_000482 O=C1NC(=O)C(=Cc2cn(Cc3ccccc3)c4ccccc24)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F21 compound treatment 99000.0 14600.0 0.24 100160.0 16900.0 0.27 0.3608 0.9984 3020548 ChemDiv3_000483 c1cc2cc(oc2s1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F22 compound treatment 37040.0 -47400.0 -0.78 51000.0 -32200.0 -0.51 -0.9164 -0.9793 1488230 ChemDiv3_000484 COc1ccc(NC(=O)c2cc3cc(OC)ccc3oc2=N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F23 mock treatment 82400.0 -2020.0 -0.03 86560.0 3320.0 0.05 0.0138 0.2211 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 F24 mock treatment 40720.0 -43700.0 -0.72 31520.0 -51700.0 -0.82 -1.093 -0.9978 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G01 compound treatment 30080.0 -54300.0 -0.9 27320.0 -55900.0 -0.89 -1.2645 -1.0 1360606 ChemDiv3_000485 CC(C)C(=O)Oc1cc(OC(=O)C(C)C)c2ccccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G02 compound treatment 45440.0 -39000.0 -0.64 38560.0 -44700.0 -0.71 -0.9586 -0.9987 1922577 ChemDiv3_000486 Cc1[nH]c(=S)[nH]c1C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G03 compound treatment 63840.0 -20600.0 -0.34 67000.0 -16200.0 -0.26 -0.4233 -0.991 1463550 ChemDiv3_000487 Fc1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G04 compound treatment 125680.0 41300.0 0.68 130160.0 46900.0 0.75 1.0104 0.9989 3020549 ChemDiv3_000488 COc1ccc(/C=C\2/SC(=S)N(C)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G05 compound treatment 9360.0 -75100.0 -1.24 9280.0 -74000.0 -1.18 -1.7097 -0.9997 3117684 ChemDiv3_000489 O=C/1/C(=C/c2ccccn2)/CC\C1=C/c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G06 compound treatment 102600.0 18200.0 0.3 93720.0 10500.0 0.17 0.3303 0.9617 1021484 ChemDiv3_000490 O=C1CSC(N1Cc2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G07 compound treatment 56200.0 -28200.0 -0.47 59960.0 -23300.0 -0.37 -0.5918 -0.9937 1308794 ChemDiv3_000491 Nc1ncc(s1)c2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G08 compound treatment 132920.0 48500.0 0.8 118680.0 35400.0 0.56 0.9655 0.9854 1604550 ChemDiv3_000492 CCN1CCCC1CNC(=O)c2cc(NC(=O)C)c(cc2OC)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G09 compound treatment 104080.0 19700.0 0.32 106760.0 23500.0 0.37 0.4945 0.9974 3020550 ChemDiv3_000493 Cn/1cccc\c1=N\c2cccc[n+]2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G10 compound treatment 129240.0 44800.0 0.74 131000.0 47800.0 0.76 1.0614 0.9999 3020551 ChemDiv3_000494 Cc1ccc(/C=N/c2cccc(Cl)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G11 compound treatment 21000.0 -63400.0 -1.05 20520.0 -62700.0 -1.0 -1.4472 -0.9997 1452502 ChemDiv3_000495 Cc1cc(Nc2ccc(Cl)cc2)n3c4ccccc4nc3c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G12 compound treatment 161360.0 76900.0 1.27 147000.0 63800.0 1.02 1.6166 0.9939 1609352 ChemDiv3_000496 Nc1ccc2[nH]c(nc2c1)c3ccccc3c4nc5cc(N)ccc5[nH]4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G13 compound treatment 147320.0 62900.0 1.04 149680.0 66400.0 1.06 1.483 1.0 3117685 ChemDiv3_000497 Cc1ccc(NS(=O)(=O)c2cc(ccc2Br)C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G14 compound treatment 138880.0 54500.0 0.9 152480.0 69200.0 1.1 1.416 0.9948 1253750 ChemDiv3_000498 COc1ccc(cc1)N(C2SC(=O)N(C2=O)c3ccccc3)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G15 compound treatment 125880.0 41500.0 0.68 144240.0 61000.0 0.97 1.1714 0.9852 3020552 ChemDiv3_000499 Cc1nc2ccc3nc(NC(=O)c4ccccc4C)sc3c2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G16 compound treatment 44680.0 -39700.0 -0.66 56040.0 -27200.0 -0.43 -0.7704 -0.9798 3117686 ChemDiv3_000500 CCOc1ccc(cc1)[n+]2c(cn3CCCCCc32)c4ccc(OC)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G17 compound treatment 97800.0 13400.0 0.22 95600.0 12400.0 0.2 0.2954 0.9984 1162912 ChemDiv3_000501 CCc1ccc(cc1)c2nc3ccccc3c(=O)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G18 compound treatment 110280.0 25900.0 0.43 122520.0 39300.0 0.63 0.7445 0.9826 1671355 ChemDiv3_000502 O=C(Oc1ccc2cc(OC(=O)c3ccccc3)ccc2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G19 compound treatment 120720.0 36300.0 0.6 141160.0 57900.0 0.92 1.0765 0.9781 1168078 ChemDiv3_000503 COC(=O)C1=C(C)NC(=O)NC1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G20 compound treatment 110560.0 26100.0 0.43 132320.0 49100.0 0.78 0.8582 0.9607 1591511 ChemDiv3_000504 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G21 compound treatment 68400.0 -16000.0 -0.26 70720.0 -12500.0 -0.2 -0.3281 -0.9904 1660119 ChemDiv3_000505 CCOC(=O)c1c(NC(=O)c2ccccc2C(=O)O)sc3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G22 compound treatment 10360.0 -74100.0 -1.22 14480.0 -68800.0 -1.1 -1.6394 -0.9985 1447109 ChemDiv3_000506 CC(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G23 mock treatment 83960.0 -458.0 -0.01 88320.0 5080.0 0.08 0.0519 0.6383 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 G24 mock treatment 62600.0 -21800.0 -0.36 65720.0 -17500.0 -0.28 -0.4522 -0.9921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H01 compound treatment 12040.0 -72400.0 -1.19 6440.0 -76800.0 -1.22 -1.7104 -0.9999 1421806 ChemDiv3_000507 Nc1sc(c(Cc2ccccc2)c1C(=O)O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H02 compound treatment 45920.0 -38500.0 -0.64 56480.0 -26800.0 -0.43 -0.751 -0.9812 3020553 ChemDiv3_000508 Cc1ccc2n(CC=C)c(=O)n(CC=C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H03 compound treatment 15600.0 -68800.0 -1.14 13400.0 -69800.0 -1.11 -1.5904 -0.9999 3117687 ChemDiv3_000509 Clc1ccccc1/C=C/C=N/c2ccc(cc2)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H04 compound treatment 28080.0 -56300.0 -0.93 27720.0 -55500.0 -0.88 -1.2834 -0.9997 1282292 ChemDiv3_000510 CC(C)CNP(=O)(OC1CC(C)CCC1C(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H05 compound treatment 157000.0 72600.0 1.2 170520.0 87300.0 1.39 1.8308 0.9972 3020554 ChemDiv3_000511 CN1C(=O)N(C)C(=O)C(=CNC2(CC3CC4CC(C3)C2)C4)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H06 compound treatment 146880.0 62500.0 1.03 150840.0 67600.0 1.08 1.4909 0.9998 1916294 ChemDiv3_000512 O=C(NC(Sc1ncccn1)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H07 compound treatment 119000.0 34600.0 0.57 156560.0 73300.0 1.17 1.2299 0.9457 1433778 ChemDiv3_000513 OC(=O)CSc1nc2ccccc2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H08 compound treatment 87800.0 3380.0 0.06 109480.0 26200.0 0.42 0.3352 0.7945 1920143 ChemDiv3_000514 Sc1n[n+]2c(cc(nc2s1)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H09 compound treatment 116040.0 31600.0 0.52 129120.0 45900.0 0.73 0.8861 0.9864 3020555 ChemDiv3_000515 Nc1cc(N)cc(c1)C(=O)OCN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H10 compound treatment 154160.0 69700.0 1.15 151400.0 68200.0 1.09 1.5822 0.9996 3117688 ChemDiv3_000516 O=C(NCc1ccccc1)/C(=C\c2ccccc2)/NC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H11 compound treatment 61520.0 -22900.0 -0.38 65920.0 -17300.0 -0.28 -0.4625 -0.9881 3117689 ChemDiv3_000517 CCN1/C(=C\2/N(C(=S)N(C)C2=O)c3ccccc3)/C=Cc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H12 compound treatment 159080.0 74700.0 1.23 184360.0 101000.0 1.61 2.0111 0.9912 1591023 ChemDiv3_000518 CC(=O)Nc1ccc(NS(=O)(=O)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H13 compound treatment 81520.0 -2900.0 -0.05 87560.0 4320.0 0.07 0.0148 0.1768 3020556 ChemDiv3_000519 CC/C(=C\c1sc2ccc(OC)cc2[n+]1CC)/SCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H14 compound treatment 87200.0 2780.0 0.05 120600.0 37400.0 0.6 0.4535 0.7594 1680898 ChemDiv3_000520 S=C(NC1CCCCC1)C2(CC3CC4CC(C3)CC2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H15 compound treatment 129320.0 44900.0 0.74 151160.0 67900.0 1.08 1.2895 0.9829 1183680 ChemDiv3_000521 Clc1ccccc1NC(=O)c2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H16 compound treatment 126920.0 42500.0 0.7 151400.0 68200.0 1.09 1.2642 0.9776 1868581 ChemDiv3_000522 Nc1cc(=O)[nH]c(SCC=C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H17 compound treatment 94160.0 9740.0 0.16 99920.0 16700.0 0.27 0.3016 0.971 1530765 ChemDiv3_000523 CC(C)(O)C1(CC2CC3C1)CC(C2)(C3)C(C)(C)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H18 compound treatment 118720.0 34300.0 0.57 145800.0 62600.0 1.0 1.1054 0.9641 1142850 ChemDiv3_000524 CC1(C)CC(C)(O)P(=O)(O1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H19 compound treatment 125440.0 41000.0 0.68 133440.0 50200.0 0.8 1.0445 0.9966 1258965 ChemDiv3_000525 COC(OC)(C(=O)c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H20 compound treatment 23760.0 -60700.0 -1.0 29200.0 -54000.0 -0.86 -1.3171 -0.9972 1712075 ChemDiv3_000526 Nc1ccc(cc1)C(=O)Nc2ccc(O)c(c2)c3nc4ccccc4o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H21 compound treatment 8560.0 -75900.0 -1.25 7880.0 -75400.0 -1.2 -1.7348 -0.9998 3020557 ChemDiv3_000527 CC(C)(C)N/C=C\1/C=C(SC1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H22 compound treatment 127880.0 43500.0 0.72 121120.0 37900.0 0.6 0.9342 0.9963 1374190 ChemDiv3_000528 COc1ccc(CC(CC(=O)O)C(=O)Nc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H23 mock treatment 101440.0 17000.0 0.28 83520.0 275.0 0.0 0.2018 0.718 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 H24 mock treatment 74680.0 -9740.0 -0.16 40000.0 -43200.0 -0.69 -0.601 -0.8492 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I01 compound treatment 70640.0 -13800.0 -0.23 67160.0 -16100.0 -0.26 -0.3421 -0.9982 1677573 ChemDiv3_000529 CN1C(=O)c2ccc(NC(=O)c3cccc4ccccc34)cc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I02 compound treatment 4600.0 -79800.0 -1.32 4640.0 -78600.0 -1.25 -1.8176 -0.9997 1561089 ChemDiv3_000530 C1C2CC3CC1CC(C2)(C3)c4coc(n4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I03 compound treatment 24120.0 -60300.0 -1.0 18480.0 -64800.0 -1.03 -1.4337 -0.9998 1284188 ChemDiv3_000531 CN(C)c1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I04 compound treatment 65880.0 -18500.0 -0.31 55720.0 -27500.0 -0.44 -0.5266 -0.9845 3020558 ChemDiv3_000532 O=C/1N(CNc2ccccc2)C(=S)S\C1=C\c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I05 compound treatment 93000.0 8580.0 0.14 42560.0 -40700.0 -0.65 -0.3584 -0.5399 3117690 ChemDiv3_000533 O=C/1/C(=C/c2cc3ccccc3o2)/CC\C1=C/c4cc5ccccc5o4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I06 compound treatment 10080.0 -74300.0 -1.23 9800.0 -73400.0 -1.17 -1.6954 -0.9997 1740048 ChemDiv3_000534 Cc1ccc(cc1C)C2(CC3CC4CC(CN)(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I07 compound treatment 11400.0 -73000.0 -1.21 11880.0 -71400.0 -1.14 -1.6566 -0.9996 3117691 ChemDiv3_000535 CC(C)C1CCC(C)/C(=C\c2ccc(N)cc2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I08 compound treatment 101280.0 16900.0 0.28 114080.0 30800.0 0.49 0.5443 0.9638 3020559 ChemDiv3_000536 Cc1cccc(/N=C/c2c(C)c(C#N)c3nc4ccccc4n3c2O)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I09 compound treatment 123240.0 38800.0 0.64 108040.0 24800.0 0.4 0.7326 0.973 3117692 ChemDiv3_000537 Cn1c(c2ccc3ccccc3n2)[n+](C)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I10 compound treatment 107280.0 22900.0 0.38 113640.0 30400.0 0.48 0.6094 0.9924 3020560 ChemDiv3_000538 Cc1ccc(/C=N/c2cccc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I11 compound treatment 39000.0 -45400.0 -0.75 42880.0 -40400.0 -0.64 -0.9851 -0.9971 3117694 ChemDiv3_000539 CC(C)c1c(C#N)c(N)nc(SCC(=O)c2ccc(Cl)c(Cl)c2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I12 compound treatment 89320.0 4900.0 0.08 101520.0 18300.0 0.29 0.2632 0.8706 1294664 ChemDiv3_000540 O=S(=O)(N1CCCc2ccccc12)c3ccc4ccccc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I13 compound treatment 157280.0 72900.0 1.2 173360.0 90100.0 1.44 1.8661 0.9961 3020561 ChemDiv3_000541 CCOc1c(NC(=O)c2ccc(N)cc2)cc(NC(=O)c3ccc(N)cc3)cc1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I14 compound treatment 131640.0 47200.0 0.78 152920.0 69700.0 1.11 1.3365 0.985 1029333 ChemDiv3_000542 COc1ccc(cc1)S(=O)(=O)c2ccc(OC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I15 compound treatment 40000.0 -44400.0 -0.73 51360.0 -31900.0 -0.51 -0.8778 -0.984 3117695 ChemDiv3_000543 Cc1ccc(cc1)N(CCCCN2C(=O)c3ccccc3C2=O)C(=O)c4cccc(Cl)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I16 compound treatment 79000.0 -5420.0 -0.09 86560.0 3320.0 0.05 -0.0259 -0.2491 3020562 ChemDiv3_000544 COc1ccc(cc1)C(=O)C[n+]2cc(c3ccc(OC)cc3)n4CCCCCc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I17 compound treatment 85360.0 943.0 0.02 85000.0 1760.0 0.03 0.0308 0.9617 1434553 ChemDiv3_000545 CCc1ccc(cc1)C(=O)Nc2ccc(Br)cn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I18 compound treatment 95840.0 11400.0 0.19 96240.0 13000.0 0.21 0.2798 0.9989 3117696 ChemDiv3_000546 OC1=C(C(N(C1=O)c2ccccc2)c3ccccc3)C(=O)/C=C/c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I19 compound treatment 140720.0 56300.0 0.93 163480.0 80200.0 1.28 1.5615 0.9877 1267294 ChemDiv3_000547 COc1ccc(cc1)N(CN2C(=O)c3ccccc3C2=O)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I20 compound treatment 120160.0 35700.0 0.59 104800.0 21600.0 0.34 0.6601 0.9669 1626144 ChemDiv3_000548 CC(C)C1CCC(=C(Cc2ccc(OC(=O)c3ccccc3)cc2)C1=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I21 compound treatment 107800.0 23400.0 0.39 94760.0 11500.0 0.18 0.4027 0.9422 3020563 ChemDiv3_000549 Cc1sc(NC(=O)/C=C/C(=O)O)c(C#N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I22 compound treatment 115040.0 30600.0 0.51 118760.0 35500.0 0.57 0.7577 0.9984 1738105 ChemDiv3_000550 CNC(=O)C1OC(C)(OC1C(=O)NC)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I23 mock treatment 140080.0 55700.0 0.92 124520.0 41300.0 0.66 1.1149 0.9866 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 I24 mock treatment 58320.0 -26100.0 -0.43 57200.0 -26000.0 -0.42 -0.5982 -0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J01 compound treatment 15680.0 -68700.0 -1.13 21720.0 -61500.0 -0.98 -1.4957 -0.9974 3020564 ChemDiv3_000551 COc1ccccc1NC(=O)c2c(/N=C/c3c(O)ccc4ccccc34)cnn2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J02 compound treatment 40840.0 -43600.0 -0.72 45840.0 -37400.0 -0.6 -0.9302 -0.9956 3117697 ChemDiv3_000552 FC(F)(F)c1nc2cc(Cl)ccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J03 compound treatment 58760.0 -25700.0 -0.42 64600.0 -18600.0 -0.3 -0.5096 -0.985 1921072 ChemDiv3_000553 Clc1cccc(/C=N/c2ccc(cc2)N3CCOCC3)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J04 compound treatment 119640.0 35200.0 0.58 142520.0 59300.0 0.94 1.0792 0.9728 1215794 ChemDiv3_000554 Cc1cc(C)n2c(Br)c(CSc3nc4ccccc4o3)nc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J05 compound treatment 33240.0 -51200.0 -0.84 43320.0 -39900.0 -0.64 -1.0473 -0.9902 3020627 ChemDiv3_000555 CCN(CC)c1ccc(C=C2C(=O)N(C)C(=S)N(C)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J06 compound treatment 170480.0 86100.0 1.42 184160.0 101000.0 1.61 2.1419 0.9981 1612444 ChemDiv3_000556 O=C(NCn1ccc(=O)[nH]c1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J07 compound treatment 179280.0 94900.0 1.57 170840.0 87600.0 1.4 2.0945 0.9984 1318279 ChemDiv3_000557 S=C(N1CCOCC1)c2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J08 compound treatment 151240.0 66800.0 1.1 162120.0 78900.0 1.26 1.6689 0.9979 1916211 ChemDiv3_000558 CC(=O)N[N+]1=C(N)c2ccccc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J09 compound treatment 127120.0 42700.0 0.7 120240.0 37000.0 0.59 0.9154 0.9961 3020628 ChemDiv3_000559 Cc1c(/C=C/2\SC(=NC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J10 compound treatment 126760.0 42300.0 0.7 142640.0 59400.0 0.95 1.1636 0.9889 1181384 ChemDiv3_000560 CCN(CC)Cn1c(=S)oc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J11 compound treatment 150040.0 65600.0 1.08 158480.0 75200.0 1.2 1.6139 0.9987 1918939 ChemDiv3_000561 CCn1c(C)nc2cc(ccc12)S(=O)(=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J12 compound treatment 180560.0 96100.0 1.59 182280.0 99000.0 1.58 2.2384 1.0 1013703 ChemDiv3_000562 OC(=O)CNc1ccc(cc1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J13 compound treatment 172640.0 88200.0 1.46 183360.0 100000.0 1.6 2.1581 0.999 3117698 ChemDiv3_000563 COc1ccc2cc(C(=O)NC(=O)C)/c(=N/c3ccccc3)/oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J14 compound treatment 165600.0 81200.0 1.34 225240.0 142000.0 2.26 2.5479 0.9687 1005380 ChemDiv3_000564 O=C(Oc1cccc2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J15 compound treatment 158560.0 74100.0 1.22 183240.0 100000.0 1.59 1.9924 0.9915 1320959 ChemDiv3_000565 Cc1ccccc1NC(=O)CN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J16 compound treatment 159080.0 74700.0 1.23 153880.0 70600.0 1.13 1.6676 0.999 3117699 ChemDiv3_000566 Cc1cccc(/C=N/c2ccc(cc2)c3nc4cc(C)c(C)cc4o3)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J17 compound treatment 36360.0 -48100.0 -0.79 44800.0 -38400.0 -0.61 -0.9942 -0.9919 1212050 ChemDiv3_000567 OC1(C2CC3CC(C2)CC1C3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J18 compound treatment 128120.0 43700.0 0.72 170360.0 87100.0 1.39 1.4919 0.9535 1521008 ChemDiv3_000568 CCN(CC)P1(=O)OC(C)(C)CC1(C)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J19 compound treatment 72560.0 -11900.0 -0.2 85960.0 2720.0 0.04 -0.1078 -0.5378 1778430 ChemDiv3_000569 CCN1C(=O)/C(=C\2/C=Cc3ccccc3N2CC)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J20 compound treatment 144440.0 60000.0 0.99 137240.0 54000.0 0.86 1.3091 0.9975 1147350 ChemDiv3_000570 Clc1cccc(NCN2C(=O)CCC2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J21 compound treatment 10960.0 -73500.0 -1.21 10320.0 -72900.0 -1.16 -1.6793 -0.9998 3020629 ChemDiv3_000571 CN(C)/C=C\1/C=C(SC1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J22 compound treatment 69760.0 -14700.0 -0.24 89320.0 6080.0 0.1 -0.1026 -0.3938 3117701 ChemDiv3_000572 CC(CC(=O)Nc1ccccc1I)Cc2cc(C)cc(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J23 mock treatment 122120.0 37700.0 0.62 110360.0 27100.0 0.43 0.7457 0.9841 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 J24 mock treatment 75400.0 -9020.0 -0.15 78320.0 -4930.0 -0.08 -0.1608 -0.9553 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K01 compound treatment 92920.0 8500.0 0.14 87920.0 4680.0 0.07 0.1519 0.9561 3020630 ChemDiv3_000573 Brc1ccc(/C=N/c2nnc(NC(=O)/C=C/c3ccccc3)s2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K02 compound treatment 6240.0 -78200.0 -1.29 6160.0 -77100.0 -1.23 -1.7813 -0.9997 1679209 ChemDiv3_000574 O=C(CSC#N)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K03 compound treatment 51240.0 -33200.0 -0.55 55360.0 -27900.0 -0.44 -0.7015 -0.9946 1307245 ChemDiv3_000575 CCN(CC)c1ccc(cc1)C2C3=C(CC(C)(C)CC3=O)OC4=C2C(=O)CC(C)(C)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K04 compound treatment 84840.0 423.0 0.01 80200.0 -3050.0 -0.05 -0.0294 -0.5993 3020631 ChemDiv3_000576 FC(F)(F)C(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K05 compound treatment 75520.0 -8900.0 -0.15 77600.0 -5650.0 -0.09 -0.1675 -0.9723 3117702 ChemDiv3_000577 COC(=O)CNC(c1ccccc1)c2cc(Br)ccc2/N=C/c3ccccc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K06 compound treatment 161880.0 77500.0 1.28 170560.0 87300.0 1.39 1.8882 0.9991 3020632 ChemDiv3_000578 CC(=C)C(=O)Nc1ccc2C(=O)NC(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K07 compound treatment 46320.0 -38100.0 -0.63 59080.0 -24200.0 -0.39 -0.717 -0.9723 3117703 ChemDiv3_000579 CC(C)C1CCC(C)/C(=C\c2ccc(cc2)N(C)C)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K08 compound treatment 74680.0 -9740.0 -0.16 75760.0 -7490.0 -0.12 -0.198 -0.9892 3020633 ChemDiv3_000580 COc1ccc(/C=C/2\Cc3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K09 compound treatment 188600.0 104000.0 1.72 201800.0 119000.0 1.89 2.5522 0.9989 3020634 ChemDiv3_000581 C[n+]1cc(cc2ccccc12)c3ccc4ccccc4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K10 compound treatment 171560.0 87100.0 1.44 186680.0 103000.0 1.65 2.1829 0.9977 3117704 ChemDiv3_000582 CC(=O)Nc1ccc(/N=C/c2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K11 compound treatment 167400.0 83000.0 1.37 177320.0 94100.0 1.5 2.0288 0.999 1317973 ChemDiv3_000583 CC(=O)NS(=O)(=O)c1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K12 compound treatment 171640.0 87200.0 1.44 200720.0 117000.0 1.87 2.3421 0.9916 1685696 ChemDiv3_000584 COCc1cc(C)nc(N2CCOCC2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K13 compound treatment 11600.0 -72800.0 -1.2 13160.0 -70100.0 -1.12 -1.6398 -0.9993 1680270 ChemDiv3_000585 CCCCN1CCN(CC1)c2nc(c3ccccc3)c4cc(C)ccc4n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K14 compound treatment 28160.0 -56300.0 -0.93 47720.0 -35500.0 -0.57 -1.057 -0.9718 3020635 ChemDiv3_000586 COC(=O)Oc1cc2oc(=O)sc2cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K15 compound treatment 77680.0 -6740.0 -0.11 96320.0 13100.0 0.21 0.0687 0.2909 3117705 ChemDiv3_000587 COc1ccc(cc1)C(=O)N(CCCCN2C(=O)c3ccccc3C2=O)c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K16 compound treatment 148280.0 63900.0 1.05 163720.0 80500.0 1.28 1.6524 0.9953 1915086 ChemDiv3_000588 OCCNC(=S)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K17 compound treatment 158280.0 73900.0 1.22 121400.0 38200.0 0.61 1.2922 0.9484 3020636 ChemDiv3_000589 CCc1ccc(cc1)C(=O)Nc2nccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K18 compound treatment 145840.0 61400.0 1.01 164640.0 81400.0 1.3 1.6343 0.9926 1362496 ChemDiv3_000590 O=C(Nn1cnc2ccccc2c1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K19 compound treatment 151040.0 66600.0 1.1 173440.0 90200.0 1.44 1.7942 0.9913 3117706 ChemDiv3_000591 NC(=O)C[n+]1cccc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K20 compound treatment 112000.0 27600.0 0.46 146040.0 62800.0 1.0 1.0297 0.9364 3117707 ChemDiv3_000592 C/C(=N\N)/c1c(c2ccccc2)c3cc(Br)ccc3[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K21 compound treatment 161160.0 76700.0 1.27 142880.0 59600.0 0.95 1.5679 0.99 1318329 ChemDiv3_000593 OCC1(CC2CC3C1)CC(CO)(C2)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K22 compound treatment 139160.0 54700.0 0.9 156080.0 72800.0 1.16 1.4598 0.9923 1110839 ChemDiv3_000594 OC(=O)c1ccccc1C(=O)OCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K23 mock treatment 99000.0 14600.0 0.24 116560.0 33300.0 0.53 0.5457 0.936 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 K24 mock treatment 117280.0 32900.0 0.54 113360.0 30100.0 0.48 0.723 0.9981 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L01 compound treatment 96520.0 12100.0 0.2 110120.0 26900.0 0.43 0.4442 0.9397 1272387 ChemDiv3_000595 CC(=O)Nc1ccc(NC(=O)c2ccnn2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L02 compound treatment 123280.0 38900.0 0.64 100320.0 17100.0 0.27 0.6461 0.9271 3020637 ChemDiv3_000596 C(Sc1nnc(o1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L03 compound treatment 96840.0 12400.0 0.21 103280.0 20000.0 0.32 0.3708 0.9771 3117708 ChemDiv3_000597 COC(=O)c1ccc(/C=N/c2ccc3oc(nc3c2)c4cccc(OC)c4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L04 compound treatment 71280.0 -13100.0 -0.22 83720.0 475.0 0.01 -0.148 -0.682 3020638 ChemDiv3_000598 Cc1csc2nc(CSc3ccc(Cl)cc3)c(Br)n12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L05 compound treatment 154560.0 70100.0 1.16 149520.0 66300.0 1.06 1.5657 0.999 3117709 ChemDiv3_000599 CC(=O)NC(=O)c/1cc2ccccc2o\c1=N/c3ccc(cc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L06 compound treatment 89280.0 4860.0 0.08 121960.0 38700.0 0.62 0.4931 0.7924 3020639 ChemDiv3_000600 S=c1cc[nH]c(=S)n1c2nc(sc2c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L07 compound treatment 151680.0 67300.0 1.11 190160.0 107000.0 1.7 1.9901 0.9785 3117710 ChemDiv3_000601 CC(=O)N1CCc2cc(/N=C/c3ccc(Cl)cc3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L08 compound treatment 151600.0 67200.0 1.11 178120.0 94900.0 1.51 1.8534 0.9884 3020640 ChemDiv3_000602 Cc1nc2ccc(/N=C/c3ccc(Br)cc3)cc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L09 compound treatment 144640.0 60200.0 0.99 150760.0 67500.0 1.08 1.4638 0.9992 3117711 ChemDiv3_000603 Cc1n[nH]c(C)c1Sc2ccccc2/N=C/c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L10 compound treatment 183240.0 98800.0 1.63 193800.0 111000.0 1.76 2.3995 0.9993 1663127 ChemDiv3_000604 CC(C)OC(=O)C1=C(C)NC(=S)NC1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L11 compound treatment 70320.0 -14100.0 -0.23 73000.0 -10200.0 -0.16 -0.28 -0.985 1238798 ChemDiv3_000605 CC[N+]1=C(C)C(C)(C)c2cc(ccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L12 compound treatment 25560.0 -58900.0 -0.97 21960.0 -61300.0 -0.98 -1.3777 -1.0 3117713 ChemDiv3_000606 Brc1cccc(NC(=O)c2cccc3-c4ccccc4C(=O)c32)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L13 compound treatment 16520.0 -67900.0 -1.12 20280.0 -63000.0 -1.0 -1.5022 -0.9985 1507618 ChemDiv3_000607 COc1ccc2oc(=N)c(cc2c1)c3nc4ccccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L14 compound treatment 165400.0 81000.0 1.34 183800.0 101000.0 1.6 2.0785 0.9959 3020641 ChemDiv3_000608 CNc1ncnc(S)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L15 compound treatment 169160.0 84700.0 1.4 180320.0 97100.0 1.55 2.0832 0.9987 1703537 ChemDiv3_000609 O=C(CN1C(=O)c2ccccc2C1=O)Nc3nccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L16 compound treatment 150400.0 66000.0 1.09 166600.0 83400.0 1.33 1.7096 0.9951 3117714 ChemDiv3_000610 Oc1ccc(Cl)cc1/C=N/c2ccc3oc(Cc4ccc(Cl)cc4)nc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L17 compound treatment 165520.0 81100.0 1.34 194480.0 111000.0 1.77 2.2003 0.9904 1529335 ChemDiv3_000611 OC(=O)C=C1C2CC3CC(C2)CC1C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L18 compound treatment 56720.0 -27700.0 -0.46 100320.0 17100.0 0.27 -0.1309 -0.2459 3117715 ChemDiv3_000612 Clc1ccccc1/C=C\2/SC(=O)N(C2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L19 compound treatment 153520.0 69100.0 1.14 153080.0 69800.0 1.11 1.5936 0.9999 3117716 ChemDiv3_000613 CCOc1ccc(/C=C(\NC(=O)c2ccccc2)/C(=O)NC)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L20 compound treatment 152200.0 67800.0 1.12 156680.0 73400.0 1.17 1.6188 0.9997 3020642 ChemDiv3_000614 COc1cccc2ccc(Cl)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L21 compound treatment 11400.0 -73000.0 -1.21 11040.0 -72200.0 -1.15 -1.6661 -0.9997 3020643 ChemDiv3_000615 CN/C=C\1/C=C(SC1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L22 compound treatment 110400.0 26000.0 0.43 123600.0 40400.0 0.64 0.7581 0.9806 3117717 ChemDiv3_000616 N#CCC(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L23 mock treatment 127280.0 42900.0 0.71 109120.0 25900.0 0.41 0.7919 0.967 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 L24 mock treatment 102800.0 18400.0 0.3 106080.0 22800.0 0.36 0.4719 0.9959 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M01 compound treatment 8480.0 -75900.0 -1.25 6680.0 -76600.0 -1.22 -1.7493 -0.9999 1490670 ChemDiv3_000617 O=C(Oc1ccccc1)Oc2ccc3oc(=O)sc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M02 compound treatment 137160.0 52700.0 0.87 105000.0 21800.0 0.35 0.8608 0.9186 3117718 ChemDiv3_000618 Cc1ccc(Oc2ccc(C)c(C)c2)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M03 compound treatment 77440.0 -6980.0 -0.12 47360.0 -35900.0 -0.57 -0.4859 -0.8328 1380597 ChemDiv3_000619 COc1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M04 compound treatment 137960.0 53500.0 0.88 98200.0 15000.0 0.24 0.7935 0.8668 3020644 ChemDiv3_000620 FC(F)(F)C(=O)N(CN1C(=O)CCC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M05 compound treatment 142080.0 57700.0 0.95 139360.0 56100.0 0.89 1.3055 0.9995 1629777 ChemDiv3_000621 Nc1ccc(Br)cc1C(O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M06 compound treatment 179960.0 95500.0 1.58 173040.0 89800.0 1.43 2.1272 0.9988 3117719 ChemDiv3_000622 CNc1cc(NC)c2ncnc3-c4ccccc4C(=O)c1c32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M07 compound treatment 161160.0 76700.0 1.27 125920.0 42700.0 0.68 1.3767 0.9575 3020645 ChemDiv3_000623 CC(C)C1CCC(C)/C(=C/c2ccc(NC(=O)CCC(=O)O)cc2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M08 compound treatment 168880.0 84500.0 1.39 166400.0 83200.0 1.33 1.9231 0.9997 1472960 ChemDiv3_000624 COc1ccc2CN(C(=O)c2c1OC)c3nnc[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M09 compound treatment 122800.0 38400.0 0.63 70320.0 -12900.0 -0.21 0.3023 0.4538 3020646 ChemDiv3_000625 CC(=O)n1c2ccccc2c3cc(Br)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M10 compound treatment 183200.0 98800.0 1.63 207520.0 124000.0 1.98 2.5536 0.9953 3117720 ChemDiv3_000626 COc1ccc(/C=N/c2cccc(Cl)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M11 compound treatment 34800.0 -49600.0 -0.82 25320.0 -57900.0 -0.92 -1.232 -0.9982 1922766 ChemDiv3_000627 Oc1ccccc1/C=N/c2ccc(cc2)c3nc4ccccc4s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M12 compound treatment 159360.0 74900.0 1.24 159480.0 76200.0 1.22 1.7339 1.0 3020648 ChemDiv3_000628 CCN1C(=C(C#N)C#N)C=Cc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M13 compound treatment 169280.0 84900.0 1.4 169720.0 86500.0 1.38 1.9651 1.0 1708776 ChemDiv3_000629 C1CC[N+]2(C1)CCN(CC2)c3ncccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M14 compound treatment 168360.0 83900.0 1.39 157720.0 74500.0 1.19 1.8192 0.997 1728722 ChemDiv3_000630 COc1ccc(cc1)N2C(=O)c3ccc(Oc4ccccc4)cc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M15 compound treatment 90000.0 5580.0 0.09 72160.0 -11100.0 -0.18 -0.0598 -0.2999 3020649 ChemDiv3_000631 COc1cccc(/N=C\c2c[nH]c3ccccc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M16 compound treatment 101480.0 17100.0 0.28 99600.0 16400.0 0.26 0.3835 0.9993 3117721 ChemDiv3_000632 Brc1ccc2NC(=O)CN(C(c3ccccc3)c2c1)C(=O)/C=C/c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M17 compound treatment 130000.0 45600.0 0.75 142160.0 58900.0 0.94 1.196 0.994 1294702 ChemDiv3_000633 C1CCCN(CC1)c2nc(nc(n2)N3CCCCCC3)N4CCCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M18 compound treatment 157080.0 72700.0 1.2 158560.0 75300.0 1.2 1.697 1.0 3117722 ChemDiv3_000634 Brc1ccc(NC(=O)Nc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M19 compound treatment 36480.0 -47900.0 -0.79 38640.0 -44600.0 -0.71 -1.0623 -0.9986 1311944 ChemDiv3_000635 c1c(nc2ccccn12)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M20 compound treatment 148240.0 63800.0 1.05 146440.0 63200.0 1.01 1.4572 0.9997 1216291 ChemDiv3_000636 OCCNC(=S)NC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M21 compound treatment 50600.0 -33800.0 -0.56 51320.0 -31900.0 -0.51 -0.7545 -0.9989 1664260 ChemDiv3_000637 OC(=O)c1cc(ccc1O)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M22 compound treatment 166080.0 81700.0 1.35 132920.0 49700.0 0.79 1.513 0.9678 3020650 ChemDiv3_000638 Fc1ccccc1C(=O)Nc2cc(ccc2Br)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M23 mock treatment 119000.0 34600.0 0.57 138880.0 55600.0 0.89 1.0307 0.9773 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 M24 mock treatment 97040.0 12600.0 0.21 101360.0 18100.0 0.29 0.3515 0.9872 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N01 compound treatment 113640.0 29200.0 0.48 85920.0 2680.0 0.04 0.3712 0.7666 3020651 ChemDiv3_000639 Cn1nccc1C(=O)Nc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N02 compound treatment 155280.0 70900.0 1.17 151640.0 68400.0 1.09 1.598 0.9994 3117723 ChemDiv3_000640 COC(=O)CSc1nnc(o1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N03 compound treatment 81440.0 -2980.0 -0.05 73480.0 -9770.0 -0.16 -0.1448 -0.8872 3117724 ChemDiv3_000641 COc1cc(Br)cc(/C=N/c2cccc(c2)c3nc4ccccc4o3)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N04 compound treatment 122760.0 38300.0 0.63 121000.0 37800.0 0.6 0.8731 0.9997 1628862 ChemDiv3_000642 CCOC(=O)c1csc(NC(=O)c2ccc(cc2)S(=O)(=O)N(CC)CC)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N05 compound treatment 114560.0 30100.0 0.5 107640.0 24400.0 0.39 0.6268 0.9926 1290427 ChemDiv3_000643 CC(=O)Oc1ccccc1N(C(=O)C)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N06 compound treatment 196840.0 112000.0 1.86 184480.0 101000.0 1.61 2.4532 0.9976 1570356 ChemDiv3_000644 CC(C)(C)C(=O)Nc1c(Cl)sc2nccc(=O)n12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N07 compound treatment 145640.0 61200.0 1.01 157360.0 74100.0 1.18 1.5499 0.997 3020698 ChemDiv3_000645 CC(=O)N1CCc2cc(/N=C/c3ccc(O)cc3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N08 compound treatment 11080.0 -73300.0 -1.21 11120.0 -72100.0 -1.15 -1.6689 -0.9997 3020699 ChemDiv3_000646 CN(C)/C=C/c1cc(=S)c2ccccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N09 compound treatment 151560.0 67100.0 1.11 168400.0 85200.0 1.36 1.7434 0.9949 1598396 ChemDiv3_000647 CSc1nnc-2c(OC(Nc3ccccc32)C4CCC(=CC4)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N10 compound treatment 10880.0 -73500.0 -1.21 10400.0 -72800.0 -1.16 -1.6793 -0.9998 3020700 ChemDiv3_000648 Oc1ccc(/C=C/2\SC(=S)N(CCc3ccccc3)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N11 compound treatment 44880.0 -39500.0 -0.65 41760.0 -41500.0 -0.66 -0.929 -1.0 3020701 ChemDiv3_000649 CN1/C(=C/C=C/c2oc3ccccc3[n+]2C)/Oc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N12 compound treatment 19080.0 -65300.0 -1.08 27960.0 -55300.0 -0.88 -1.3857 -0.995 3117725 ChemDiv3_000650 Clc1ccc(/C=N/C(=O)CC#N)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N13 compound treatment 15720.0 -68700.0 -1.13 11560.0 -71700.0 -1.14 -1.6098 -1.0 1340722 ChemDiv3_000651 N=c1oc2ccc3ccccc3c2cc1C(=O)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N14 compound treatment 10800.0 -73600.0 -1.22 10200.0 -73000.0 -1.16 -1.6825 -0.9998 3117726 ChemDiv3_000652 COc1cc(/C=C\2/SC(=S)N(CC=C)C2=O)ccc1OC(=O)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N15 compound treatment 77320.0 -7100.0 -0.12 53280.0 -30000.0 -0.48 -0.4206 -0.8552 3020702 ChemDiv3_000653 CC1=N/C(=C/c2cccnc2)/C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N16 compound treatment 103480.0 19100.0 0.31 90160.0 6920.0 0.11 0.3004 0.9011 3117727 ChemDiv3_000654 CCN1/C(=C/c2ccc3ccccc3[n+]2CC)/Sc4cc(NC(=O)C)ccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N17 compound treatment 62640.0 -21800.0 -0.36 54200.0 -29000.0 -0.46 -0.5815 -0.9922 1208186 ChemDiv3_000655 OC(=O)c1cc(nc2ccc(Br)cc12)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N18 compound treatment 167520.0 83100.0 1.37 175040.0 91800.0 1.46 2.0046 0.9995 3020703 ChemDiv3_000656 CCN1C(=O)/C(=C\C(=C\c2ccccc2)\C)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N19 compound treatment 10000.0 -74400.0 -1.23 9720.0 -73500.0 -1.17 -1.6973 -0.9997 3020704 ChemDiv3_000657 CN1C(=O)/C(=C\Nc2ccccc2)/C=C1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N20 compound treatment 29520.0 -54900.0 -0.91 33040.0 -50200.0 -0.8 -1.2066 -0.9981 3117728 ChemDiv3_000658 Cc1cccc(c1)N2C(=O)/C(=C\3/C(=O)Nc4ccccc34)/SC2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N21 compound treatment 129960.0 45500.0 0.75 135640.0 52400.0 0.84 1.1221 0.9986 1544837 ChemDiv3_000659 Cc1cc(=O)nc(SCc2nc3ccccc3[nH]2)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N22 compound treatment 120320.0 35900.0 0.59 142360.0 59100.0 0.94 1.0853 0.975 1021435 ChemDiv3_000660 Nc1ccc(NS(=O)(=O)c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N23 mock treatment 137240.0 52800.0 0.87 125720.0 42500.0 0.68 1.0953 0.9922 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 N24 mock treatment 85600.0 1180.0 0.02 110280.0 27000.0 0.43 0.3185 0.7384 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O01 compound treatment 74080.0 -10300.0 -0.17 71400.0 -11800.0 -0.19 -0.2542 -0.9987 1913320 ChemDiv3_000661 O=C(Oc1ccccc1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O02 compound treatment 39000.0 -45400.0 -0.75 47680.0 -35600.0 -0.57 -0.931 -0.9905 3020705 ChemDiv3_000662 Cc1cc(C)c(NC(=S)NC(=O)c2ccccc2)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O03 compound treatment 113320.0 28900.0 0.48 78800.0 -4450.0 -0.07 0.2873 0.5956 3117729 ChemDiv3_000663 CCOc1ccc(N/C=N/c2ccc(OCC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O04 compound treatment 150200.0 65800.0 1.09 139560.0 56300.0 0.9 1.4025 0.9955 1253491 ChemDiv3_000664 N#CCCN(Cn1c2ccccc2c3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O05 compound treatment 137960.0 53500.0 0.88 122880.0 39600.0 0.63 1.0717 0.9864 1678987 ChemDiv3_000665 Cc1ccc2nc(cc(C(=O)NCc3ccccc3)c2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O06 compound treatment 157200.0 72800.0 1.2 125640.0 42400.0 0.68 1.3273 0.9629 1464157 ChemDiv3_000666 Cc1cc(C)c(cc1C(=O)c2ccccc2)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O07 compound treatment 12800.0 -71600.0 -1.18 14200.0 -69000.0 -1.1 -1.6141 -0.9994 1645442 ChemDiv3_000667 CCOC(=O)c1ccc(NC(=O)CCc2c[nH]c3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O08 compound treatment 8800.0 -75600.0 -1.25 9200.0 -74000.0 -1.18 -1.7171 -0.9996 1026640 ChemDiv3_000668 Nc1ccccc1CC(c2c[nH]c3ccccc23)c4c[nH]c5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O09 compound treatment 140400.0 56000.0 0.92 124960.0 41700.0 0.66 1.1236 0.987 1267081 ChemDiv3_000669 CCN(CC)S(=O)(=O)c1cc(ccc1C)C(=O)Nc2ccccc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O10 compound treatment 133960.0 49500.0 0.82 132000.0 48800.0 0.78 1.1278 0.9997 3117730 ChemDiv3_000670 CCOc1ccc(/C=N/c2ccc3sc(C)nc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O11 compound treatment 90600.0 6180.0 0.1 64680.0 -18600.0 -0.3 -0.1371 -0.4379 3020706 ChemDiv3_000671 CC(C)(C)c1cc(c2OCN(CC(=O)O)Cc2c1)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O12 compound treatment 34600.0 -49800.0 -0.82 31520.0 -51700.0 -0.82 -1.1644 -1.0 3117731 ChemDiv3_000672 CCN(CC)c1ccc2cc(C(=O)N)/c(=N/c3ccc(F)cc3)/oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O13 compound treatment 27160.0 -57300.0 -0.95 22520.0 -60700.0 -0.97 -1.3527 -0.9999 3020707 ChemDiv3_000673 Clc1ccc2nc(Cl)cc(c3ccccc3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O14 compound treatment 143000.0 58600.0 0.97 138000.0 54800.0 0.87 1.3009 0.9987 3117732 ChemDiv3_000674 Cc1cccc(C)c1OC(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O15 compound treatment 11480.0 -72900.0 -1.2 10960.0 -72300.0 -1.15 -1.666 -0.9998 3020708 ChemDiv3_000675 C(=N/c1cccc2ccccc12)/c3c[nH]c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O16 compound treatment 162720.0 78300.0 1.29 157680.0 74400.0 1.19 1.7529 0.9991 1675948 ChemDiv3_000676 OC(=O)C(NC(=O)c1ccc(F)cc1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O17 compound treatment 128680.0 44300.0 0.73 93560.0 10300.0 0.16 0.6329 0.8451 1019063 ChemDiv3_000677 CC(C)(C)c1ccc(O)c(N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O18 compound treatment 134400.0 50000.0 0.83 138560.0 55300.0 0.88 1.2068 0.9995 1676074 ChemDiv3_000678 OC(=O)C1CCC(CC1)c2ccc(cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O19 compound treatment 171960.0 87500.0 1.45 177360.0 94100.0 1.5 2.0825 0.9998 3020709 ChemDiv3_000679 CC(C(=O)c1ccccc1)[n+]2cccc(Br)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O20 compound treatment 33200.0 -51200.0 -0.85 35040.0 -48200.0 -0.77 -1.1411 -0.9989 1276194 ChemDiv3_000680 CC1(CC2CC3C1)CC(C2)(C3)NC(=O)c4ccc(Cl)cc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O21 compound treatment 157800.0 73400.0 1.21 148760.0 65500.0 1.04 1.5949 0.9973 1695393 ChemDiv3_000681 O=C(N1CCOCC1)C2(CC3CC4C2)CC(C3)(C4)C(=O)N5CCOCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O22 compound treatment 123920.0 39500.0 0.65 146880.0 63600.0 1.01 1.1783 0.9772 1315761 ChemDiv3_000682 CCN(CC)S(=O)(=O)c1cccc2cc(C(=O)O)c(O)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O23 mock treatment 140800.0 56400.0 0.93 139400.0 56200.0 0.9 1.291 0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 O24 mock treatment 125240.0 40800.0 0.67 135960.0 52700.0 0.84 1.0706 0.994 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P01 compound treatment 38040.0 -46400.0 -0.77 42720.0 -40500.0 -0.65 -0.9981 -0.9964 1316678 ChemDiv3_000683 O=C(c1ccccc1)C2(CN3CN4CN(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P02 compound treatment 93000.0 8580.0 0.14 68000.0 -15200.0 -0.24 -0.0716 -0.2547 3117733 ChemDiv3_000684 CC(C)OC(=O)CSc1nnc(o1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P03 compound treatment 97520.0 13100.0 0.22 108840.0 25600.0 0.41 0.4414 0.956 1919584 ChemDiv3_000685 Oc1ccccc1/C=N/c2ccc3oc(nc3c2)c4cccc(I)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P04 compound treatment 94240.0 9820.0 0.16 93400.0 10200.0 0.16 0.2291 1.0 3020710 ChemDiv3_000686 OCCNC(=O)c1cc[n+](CC(=O)c2cccs2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P05 compound treatment 122400.0 38000.0 0.63 108520.0 25300.0 0.4 0.7282 0.9771 1512305 ChemDiv3_000687 O=C(Oc1ccccc1N(C(=O)c2ccccc2)S(=O)(=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P06 compound treatment 66280.0 -18100.0 -0.3 55840.0 -27400.0 -0.44 -0.5206 -0.983 3020711 ChemDiv3_000688 Cc1ccc(/N=C/c2cn(nc2c3ccccc3)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P07 compound treatment 136400.0 52000.0 0.86 181400.0 98200.0 1.56 1.713 0.96 1010956 ChemDiv3_000689 FC(F)(F)C(=O)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P08 compound treatment 36600.0 -47800.0 -0.79 56720.0 -26500.0 -0.42 -0.8571 -0.9572 3117734 ChemDiv3_000690 CC(C)C1CCC(C)CC1OC(=O)Cn2c[n+](C)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P09 compound treatment 123160.0 38700.0 0.64 121120.0 37900.0 0.6 0.8791 0.9996 3020712 ChemDiv3_000691 OC(=O)CCn1c(SCCOc2ccccc2)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P10 compound treatment 105880.0 21500.0 0.35 104800.0 21600.0 0.34 0.4934 0.9999 3117735 ChemDiv3_000692 Cc1ccc(NC(=O)CN2C(=O)/C(=C\c3ccccc3)/SC2=S)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P11 compound treatment 28280.0 -56100.0 -0.93 22440.0 -60800.0 -0.97 -1.3405 -0.9997 3020713 ChemDiv3_000693 COc1cc2sc(C)nc2c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P12 compound treatment 48800.0 -35600.0 -0.59 40320.0 -42900.0 -0.68 -0.8995 -0.9972 3117736 ChemDiv3_000694 CC1(CCC2(CC(=O)c3ccccc3)CC1)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P13 compound treatment 80440.0 -3980.0 -0.07 109800.0 26600.0 0.42 0.2529 0.5904 3020714 ChemDiv3_000695 Nc1c(C#N)c(C(=O)c2ccc(Br)cc2)n3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P14 compound treatment 194720.0 110000.0 1.82 171800.0 88600.0 1.41 2.2855 0.9921 3117737 ChemDiv3_000696 CCNc1nc(F)cc(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P15 compound treatment 127400.0 43000.0 0.71 157280.0 74000.0 1.18 1.3361 0.9704 1476541 ChemDiv3_000697 OC(=O)c1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P16 compound treatment 39680.0 -44700.0 -0.74 46960.0 -36300.0 -0.58 -0.9311 -0.9927 1722951 ChemDiv3_000698 C1CCC2(C1)Cc3ccccc3-c4nnc(c5ccccc5)n42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P17 compound treatment 11320.0 -73100.0 -1.21 25640.0 -57600.0 -0.92 -1.5024 -0.9909 3117738 ChemDiv3_000699 CCC(O)(CC)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P18 compound treatment 35120.0 -49300.0 -0.81 40080.0 -43200.0 -0.69 -1.0619 -0.9965 1912570 ChemDiv3_000700 Cc1ccc(CCS(=O)(=O)c2ccc(cc2)C(C)(C)C)c[n+]1CC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P19 compound treatment 7000.0 -77400.0 -1.28 7480.0 -75800.0 -1.21 -1.7575 -0.9996 3020715 ChemDiv3_000701 CN/C=C\1/C=C(N(C)C1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P20 compound treatment 104040.0 19600.0 0.32 105600.0 22400.0 0.36 0.481 0.9989 3117739 ChemDiv3_000702 COc1ccc(/C=C\2/SC(=S)N(CCC(=O)Nc3ccccc3)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P21 compound treatment 68240.0 -16200.0 -0.27 89400.0 6160.0 0.1 -0.1195 -0.4199 3020716 ChemDiv3_000703 COc1ccc(OCCSc2ncnc3[nH]cnc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P22 compound treatment 87680.0 3260.0 0.05 87720.0 4480.0 0.07 0.0885 0.9904 1343334 ChemDiv3_000704 COC(=O)C1=C(C)NC2=C(C1c3ccncc3)C(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P23 mock treatment 74600.0 -9820.0 -0.16 69960.0 -13300.0 -0.21 -0.2643 -0.9913 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2002 P24 mock treatment 71680.0 -12700.0 -0.21 68120.0 -15100.0 -0.24 -0.3191 -0.9977 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A01 compound treatment 71440.0 -51400.0 -0.85 78680.0 -40200.0 -0.64 -1.0526 -0.9904 1702421 ChemDiv3_001057 CCc1nccn1C(=O)CCCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A02 compound treatment 98400.0 -24400.0 -0.4 108600.0 -10300.0 -0.16 -0.4007 -0.9213 1479194 ChemDiv3_001058 Clc1ccc(cc1)C(=O)Nc2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A03 compound treatment 6920.0 -116000.0 -1.91 6360.0 -113000.0 -1.79 -2.6207 -0.9995 1673755 ChemDiv3_001059 Cc1ccc(cc1NC(=O)c2ccccc2)c3nc4ccccc4s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A04 compound treatment 101560.0 -21200.0 -0.35 80240.0 -38600.0 -0.62 -0.6834 -0.9644 3118598 ChemDiv3_001060 CC1=Nc2ccc(cc2C1(C)C)C(F)(F)F.[O-][N+](=O)c1cc([N+](=O)[O-])c([O-])c(c1)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A05 compound treatment 112000.0 -10800.0 -0.18 98800.0 -20100.0 -0.32 -0.3524 -0.962 1545532 ChemDiv3_001061 Cc1ccccc1NC(=O)CCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A06 compound treatment 37120.0 -85700.0 -1.41 37200.0 -81700.0 -1.3 -1.9206 -0.9991 1235446 ChemDiv3_001062 COC(=O)c1c(C)oc2ccc(cc12)N(C(=O)Oc3ccccc3)S(=O)(=O)c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A07 compound treatment 19080.0 -104000.0 -1.71 14000.0 -105000.0 -1.67 -2.3927 -0.9999 3118599 ChemDiv3_001063 CC1C(Cc2ccc(C)cc2)C(=O)N(C1=O)c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A08 compound treatment 53280.0 -69500.0 -1.15 60960.0 -57900.0 -0.92 -1.4642 -0.9942 1351878 ChemDiv3_001064 CC(C)(C)c1cc(c(O)c(c1)C(C)(C)C)n2nc3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A09 compound treatment 20040.0 -103000.0 -1.7 16800.0 -102000.0 -1.63 -2.3499 -0.9998 1662979 ChemDiv3_001065 CCCc1cc2c(=O)c(c(C)oc2cc1OC(=O)C)c3ccc4OCOc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A10 compound treatment 84640.0 -38200.0 -0.63 70160.0 -48700.0 -0.78 -0.9945 -0.9946 1457143 ChemDiv3_001066 Cc1ccc(cc1)S(=O)(=O)N2C(C3CC2C=C3)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A11 compound treatment 125600.0 2790.0 0.05 83960.0 -34900.0 -0.56 -0.3609 -0.6463 3020384 ChemDiv3_001067 O=C/1OC(=N\C1=C/C=C/c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A12 compound treatment 136160.0 13400.0 0.22 120000.0 1130.0 0.02 0.1686 0.7623 3118600 ChemDiv3_001068 Clc1ccc(/C=C/2\C(=O)NC(=O)N(C2=O)c3ccc(Cl)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A13 compound treatment 62640.0 -60200.0 -0.99 48880.0 -70000.0 -1.12 -1.4911 -0.9983 3020385 ChemDiv3_001069 CC(C)n1c(nc2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A14 compound treatment 74040.0 -48800.0 -0.81 68000.0 -50900.0 -0.81 -1.1426 -1.0 1226119 ChemDiv3_001070 Brc1ccc(NC(=O)C2(CC3CC4CC(C3)C2)C4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A15 compound treatment 67400.0 -55400.0 -0.91 67560.0 -51300.0 -0.82 -1.225 -0.9984 3020386 ChemDiv3_001071 N#Cc1c(/N=C/c2ccccc2)sc3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A16 compound treatment 94800.0 -28000.0 -0.46 83720.0 -35200.0 -0.56 -0.7231 -0.9954 3118601 ChemDiv3_001072 CCC1=Nc2ccc(Br)cc2C(N1CC(=O)NN)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A17 compound treatment 93640.0 -29200.0 -0.48 75360.0 -43500.0 -0.69 -0.8309 -0.9841 1259740 ChemDiv3_001073 COc1ccc(cc1)C(=O)COC(=O)CN2C(=O)C3CC=CCC3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A18 compound treatment 35800.0 -87000.0 -1.44 27120.0 -91800.0 -1.46 -2.0497 -1.0 3020387 ChemDiv3_001074 CC[n+]1c(/C=C/N(C)c2ccccc2)sc3ccc(OC)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A19 compound treatment 68040.0 -54800.0 -0.9 68960.0 -49900.0 -0.8 -1.2018 -0.998 1267587 ChemDiv3_001075 CCOc1ccc2nc(ccc2c1)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A20 compound treatment 12440.0 -110000.0 -1.82 11920.0 -107000.0 -1.7 -2.4936 -0.9994 3020388 ChemDiv3_001076 CCN1/C(=C/C2=CC(=O)CC(C)(C)C2)/Sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A21 compound treatment 123200.0 391.0 0.01 124240.0 5370.0 0.09 0.0651 0.7583 3118602 ChemDiv3_001077 Cc1n[nH]c(=S)n(/N=C/c2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A22 compound treatment 137240.0 14400.0 0.24 118280.0 -591.0 -0.01 0.1618 0.6786 1512849 ChemDiv3_001078 COc1ccccc1OC(C)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A23 mock treatment 136920.0 14100.0 0.23 124640.0 5770.0 0.09 0.2297 0.9173 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 A24 mock treatment 133320.0 10500.0 0.17 125320.0 6450.0 0.1 0.1954 0.9688 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B01 compound treatment 60760.0 -62000.0 -1.02 54080.0 -64800.0 -1.03 -1.4545 -1.0 3118603 ChemDiv3_001079 Cc1cccn2c(=O)c(/C=N/c3ccc(Cl)cc3)c(NCCO)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B02 compound treatment 135280.0 12500.0 0.21 136240.0 17400.0 0.28 0.3413 0.9894 1487953 ChemDiv3_001080 COC(=O)c1c(NC(=O)C(C)C)sc2CCCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B03 compound treatment 46080.0 -76700.0 -1.27 31920.0 -87000.0 -1.39 -1.8756 -0.999 1608654 ChemDiv3_001081 COC(=O)C1=C(CCS1)NC(=O)c2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B04 compound treatment 55760.0 -67000.0 -1.11 55280.0 -63600.0 -1.01 -1.4993 -0.999 1203988 ChemDiv3_001082 Cc1ccc(C)n1c2cccc(N)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B05 compound treatment 141360.0 18600.0 0.31 123440.0 4570.0 0.07 0.268 0.8515 1593401 ChemDiv3_001083 CCCCn1c(S)nc2n(C)c(=O)[nH]c(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B06 compound treatment 136760.0 14000.0 0.23 106440.0 -12400.0 -0.2 0.0227 0.0749 3020389 ChemDiv3_001084 OC(=O)c1ccc(/C=C\2/C(=O)NC(=O)N(C2=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B07 compound treatment 7080.0 -116000.0 -1.91 5880.0 -113000.0 -1.8 -2.6243 -0.9996 1483637 ChemDiv3_001085 COc1cc(cc(OC)c1OC)C(=O)N=C2C(=CC(=O)C=C2C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B08 compound treatment 62760.0 -60000.0 -0.99 58600.0 -60300.0 -0.96 -1.3802 -0.9999 1211323 ChemDiv3_001086 COc1ccc(CNc2ccc(F)cc2C)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B09 compound treatment 63200.0 -59600.0 -0.98 53280.0 -65600.0 -1.05 -1.435 -0.9995 1504008 ChemDiv3_001087 OC(=O)c1cccc(Nc2nc(c3ccccc3)c4ccccc4n2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B10 compound treatment 44440.0 -78400.0 -1.29 47560.0 -71300.0 -1.14 -1.7184 -0.9979 1495584 ChemDiv3_001088 CC1(C)Cc2c(C#N)c(NC(=O)C(c3ccccc3)c4ccccc4)sc2CO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B11 compound treatment 49560.0 -73200.0 -1.21 37960.0 -80900.0 -1.29 -1.7669 -0.9995 1679056 ChemDiv3_001089 COc1ccc(cc1)c2nc3ccc4ccccc4c3c5CCCCc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B12 compound treatment 93400.0 -29400.0 -0.49 63000.0 -55900.0 -0.89 -0.973 -0.9593 3118604 ChemDiv3_001090 CC(C)(C)/N=c\1/cccccc1NCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B13 compound treatment 125520.0 2710.0 0.04 106800.0 -12100.0 -0.19 -0.1044 -0.5285 3020431 ChemDiv3_001091 CC1=C/C(=C/c2ccco2)/C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B14 compound treatment 150840.0 28000.0 0.46 110400.0 -8470.0 -0.14 0.2317 0.4807 1567047 ChemDiv3_001092 COc1cc(cc(OC)c1OC)C2NCCS2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B15 compound treatment 93320.0 -29500.0 -0.49 112160.0 -6710.0 -0.11 -0.4198 -0.8424 3118605 ChemDiv3_001093 Cn1c(=O)n(C)c2ncn(C=C)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B16 compound treatment 6400.0 -116000.0 -1.92 7200.0 -112000.0 -1.78 -2.6173 -0.9993 1521623 ChemDiv3_001094 Cc1ccccc1OCC(O)Cn2c3ccccc3c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B17 compound treatment 75240.0 -47600.0 -0.79 85480.0 -33400.0 -0.53 -0.9316 -0.9821 3020432 ChemDiv3_001095 Oc1ccccc1c2cc(cc(n2)c3ccccc3)c4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B18 compound treatment 82600.0 -40200.0 -0.66 111360.0 -7510.0 -0.12 -0.554 -0.8214 1643074 ChemDiv3_001096 CN(C)c1ccc(cc1)C2C(N3C(=O)c4ccccc4C3=O)C(=O)N2c5ccc(C)c(Cl)c5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B19 compound treatment 5480.0 -117000.0 -1.94 6280.0 -113000.0 -1.79 -2.6384 -0.9993 1726140 ChemDiv3_001097 CC1(C)Cc2c(sc3ncn4nc(COc5ccc(Cl)cc5)nc4c23)C(C)(C)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B20 compound treatment 75520.0 -47300.0 -0.78 58160.0 -60700.0 -0.97 -1.2362 -0.9943 1237367 ChemDiv3_001098 O=C(C1c2ccccc2Oc3ccccc13)N4CCc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B21 compound treatment 108400.0 -14400.0 -0.24 139560.0 20700.0 0.33 0.065 0.1598 3020434 ChemDiv3_001099 CC(C)(C)OC(=O)NC(=N)n1cccn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B22 compound treatment 103480.0 -19300.0 -0.32 88320.0 -30600.0 -0.49 -0.5699 -0.979 1449384 ChemDiv3_001100 COc1ccccc1NC(=O)c2cccc(c2)S(=O)(=O)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B23 mock treatment 113200.0 -9610.0 -0.16 115280.0 -3590.0 -0.06 -0.1526 -0.9051 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 B24 mock treatment 136320.0 13500.0 0.22 123280.0 4410.0 0.07 0.2074 0.8869 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C01 compound treatment 68320.0 -54500.0 -0.9 78840.0 -40000.0 -0.64 -1.0872 -0.9859 1056652 ChemDiv3_001101 CC(C)(C)NC(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C02 compound treatment 92600.0 -30200.0 -0.5 55120.0 -63800.0 -1.02 -1.0711 -0.9463 1434405 ChemDiv3_001102 O=C(COc1ccc2ccccc2c1)Oc3ccc(cc3)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C03 compound treatment 36640.0 -86200.0 -1.42 29040.0 -89800.0 -1.43 -2.0182 -1.0 1247192 ChemDiv3_001103 CC(C)(C)c1ccc(cc1)C(=O)Nc2ccc(NC(=O)c3ccccc3F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C04 compound treatment 9640.0 -113000.0 -1.87 9880.0 -109000.0 -1.74 -2.5493 -0.9993 3020435 ChemDiv3_001104 COc1ccc(cc1)c2cs/c(=N\c3ccccc3)/n2CCCN(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C05 compound treatment 108720.0 -14100.0 -0.23 91960.0 -26900.0 -0.43 -0.4677 -0.9587 1348473 ChemDiv3_001105 O=C(Nc1cccc2ccccc12)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C06 compound treatment 111000.0 -11800.0 -0.19 92440.0 -26400.0 -0.42 -0.4357 -0.9387 1500590 ChemDiv3_001106 O=C(Nc1cc2c(ccc3ccccc32)oc1=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C07 compound treatment 83080.0 -39700.0 -0.66 85600.0 -33300.0 -0.53 -0.8387 -0.9944 1484356 ChemDiv3_001107 CCN(CC)C(=S)SCc1cn2cccc(C)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C08 compound treatment 55440.0 -67400.0 -1.11 73760.0 -45100.0 -0.72 -1.2948 -0.9777 3020436 ChemDiv3_001108 O=C(Nc1ccc(C#N)cc1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C09 compound treatment 120240.0 -2570.0 -0.04 113240.0 -5630.0 -0.09 -0.0934 -0.9414 1425597 ChemDiv3_001109 CCOC(=O)c1ccc(o1)c2coc3cc(OC(=O)C)c(CC)cc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C10 compound treatment 120600.0 -2210.0 -0.04 123000.0 4130.0 0.07 0.0208 0.2758 3118606 ChemDiv3_001110 O=C(Nc1ccccc1)/C(=C/c2ccccc2)/NC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C11 compound treatment 121720.0 -1090.0 -0.02 108600.0 -10300.0 -0.16 -0.1285 -0.78 3020437 ChemDiv3_001111 COc1ccccc1/C=C/C/2=N/C(=C\c3ccc4OCOc4c3)/C(=O)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C12 compound treatment 153960.0 31200.0 0.51 127720.0 8850.0 0.14 0.4633 0.869 3118607 ChemDiv3_001112 Cc1ccc(cc1)N2C(=O)NC(=O)/C(=C\c3ccccc3)/C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C13 compound treatment 110120.0 -12700.0 -0.21 105640.0 -13200.0 -0.21 -0.2972 -1.0 1917708 ChemDiv3_001113 Sc1nc2ccccc2n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C14 compound treatment 10040.0 -113000.0 -1.86 9160.0 -110000.0 -1.75 -2.5528 -0.9995 1591681 ChemDiv3_001114 Cc1cc(C)c2C3C=CCC3C(N4CC5CC=CC5c1c42)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C15 compound treatment 83720.0 -39100.0 -0.65 88840.0 -30000.0 -0.48 -0.7947 -0.9892 3118901 ChemDiv3_001115 Cc1sc(/N=C/c2cn(Cc3ccccc3)c4ccccc24)c(C#N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C16 compound treatment 62320.0 -60500.0 -1.0 57960.0 -60900.0 -0.97 -1.3925 -0.9999 3118746 ChemDiv3_001116 CSc1ccc(/C=N/N(C)S(=O)(=O)c2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C17 compound treatment 32040.0 -90800.0 -1.5 18360.0 -101000.0 -1.6 -2.1923 -0.9994 1358774 ChemDiv3_001117 Clc1ccc(cc1)C(=O)COC(=O)C2CC=CCC2C(=O)OCC(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C18 compound treatment 131400.0 8590.0 0.14 99200.0 -19700.0 -0.31 -0.1214 -0.3528 3118747 ChemDiv3_001118 CC[n+]1ccccc1/C=C/N(C(=O)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C19 compound treatment 19200.0 -104000.0 -1.71 23520.0 -95400.0 -1.52 -2.284 -0.9983 1915904 ChemDiv3_001119 O=C1NC(=O)/C(=C\c2ccco2)/C(=O)N1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C20 compound treatment 112120.0 -10700.0 -0.18 154000.0 35100.0 0.56 0.2711 0.4619 3118748 ChemDiv3_001120 Cc1cc(NS(=O)(=O)c2ccc(/N=C/c3ccccc3O)cc2)no1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C21 compound treatment 120360.0 -2450.0 -0.04 117680.0 -1190.0 -0.02 -0.042 -0.9406 3020438 ChemDiv3_001121 Cc1n[nH]c(=S)n(/N=C/C=C/c2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C22 compound treatment 123800.0 991.0 0.02 122040.0 3170.0 0.05 0.0473 0.8906 1314862 ChemDiv3_001122 CC(Oc1ccc2ccccc2c1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C23 mock treatment 111000.0 -11800.0 -0.19 111840.0 -7030.0 -0.11 -0.2171 -0.9655 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 C24 mock treatment 126160.0 3350.0 0.06 121520.0 2650.0 0.04 0.069 0.9911 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D01 compound treatment 16280.0 -107000.0 -1.76 14320.0 -105000.0 -1.67 -2.4218 -0.9996 3020439 ChemDiv3_001123 Clc1ccc(cc1)c2ncc3ccccn23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D02 compound treatment 107600.0 -15200.0 -0.25 101520.0 -17400.0 -0.28 -0.3731 -0.9988 1146210 ChemDiv3_001124 CN(C)CCNc1cnn(c2ccccc2)c(=O)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D03 compound treatment 77720.0 -45100.0 -0.74 77520.0 -41400.0 -0.66 -0.9923 -0.9982 1432100 ChemDiv3_001125 COC(=O)C1=C(CCS1)NC(=O)c2ccc(cc2)S(=O)(=O)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D04 compound treatment 148440.0 25600.0 0.42 128040.0 9170.0 0.15 0.4025 0.8992 1339626 ChemDiv3_001126 OC(=O)CCC(=O)Nc1sc2CCCCc2c1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D05 compound treatment 123320.0 511.0 0.01 105560.0 -13300.0 -0.21 -0.1441 -0.6784 1228834 ChemDiv3_001127 CCCCc1c(O)nc(SCCN(C)C)n(c2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D06 compound treatment 132080.0 9270.0 0.15 165320.0 46400.0 0.74 0.6317 0.8356 3020440 ChemDiv3_001128 OC(=O)COc1c(Cl)cc(C=C2C(=O)NC(=S)NC2=O)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D07 compound treatment 97120.0 -25700.0 -0.42 86320.0 -32600.0 -0.52 -0.6667 -0.995 1175621 ChemDiv3_001129 Cc1c(Cl)c(O)c(Cl)c(C)c1N(S(=O)(=O)c2ccccc2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D08 compound treatment 113760.0 -9050.0 -0.15 116840.0 -2030.0 -0.03 -0.1285 -0.8408 1419799 ChemDiv3_001130 COc1ccc(CNCc2cccc(OC)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D09 compound treatment 94560.0 -28200.0 -0.47 130680.0 11800.0 0.19 -0.1966 -0.391 1117976 ChemDiv3_001131 CCOC(=O)c1cc2ccc(OCc3ccccc3)cc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D10 compound treatment 153880.0 31100.0 0.51 124680.0 5810.0 0.09 0.4281 0.8215 1501667 ChemDiv3_001132 COC(=O)c1ccc(Oc2nc(OC)nc(n2)N(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D11 compound treatment 109760.0 -13000.0 -0.22 106280.0 -12600.0 -0.2 -0.2942 -0.9994 3118749 ChemDiv3_001133 COc1ccc(cc1)C(=O)N2N3ON=C(N3c4ccccc24)c5c(C)cc(C)cc5C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D12 compound treatment 158960.0 36200.0 0.6 155880.0 37000.0 0.59 0.8391 1.0 1634877 ChemDiv3_001134 Cc1nc(=O)c(c(C)n1c2ccc(cc2)C(=O)O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D13 compound treatment 157800.0 35000.0 0.58 157040.0 38200.0 0.61 0.8386 0.9997 3118750 ChemDiv3_001135 COc1ccc(OC)c(c1)c2cc(on2)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D14 compound treatment 154400.0 31600.0 0.52 135360.0 16500.0 0.26 0.5546 0.9497 1149659 ChemDiv3_001136 Cc1cc(nn1C(CC(=O)O)C(=O)O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D15 compound treatment 87160.0 -35600.0 -0.59 83280.0 -35600.0 -0.57 -0.8172 -0.9998 3020658 ChemDiv3_001137 Cn1c(=O)n(Cc2ccccc2)c(=O)c3n(Cc4ccccc4)c(Cl)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D16 compound treatment 145560.0 22800.0 0.38 129840.0 11000.0 0.17 0.3892 0.9395 1680766 ChemDiv3_001138 NS(=O)(=O)c1ccc(NC(=O)C2CC=CCC2C(=O)N3CCOCC3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D17 compound treatment 123400.0 591.0 0.01 119120.0 249.0 0.0 0.0097 0.9212 1707287 ChemDiv3_001139 COc1ccc(cc1)c2nc(=O)c3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D18 compound treatment 141440.0 18600.0 0.31 141120.0 22200.0 0.35 0.4682 0.9975 3118751 ChemDiv3_001140 Cc1nc2ccccc2c(=O)n1NC(=O)/C=C/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D19 compound treatment 52280.0 -70500.0 -1.16 47000.0 -71900.0 -1.15 -1.6332 -1.0 1655686 ChemDiv3_001141 C(Oc1ccccc1)c2nc3c4c5CCCCc5sc4ncn3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D20 compound treatment 82560.0 -40200.0 -0.66 93240.0 -25600.0 -0.41 -0.7587 -0.9727 1270051 ChemDiv3_001142 CCN(C(=O)C1c2ccccc2Oc3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D21 compound treatment 23240.0 -99600.0 -1.64 18960.0 -99900.0 -1.59 -2.2882 -0.9999 3020662 ChemDiv3_001143 CC(C)(C)N1Sc2ccccc2NC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D22 compound treatment 37760.0 -85000.0 -1.4 31920.0 -87000.0 -1.39 -1.9727 -1.0 1371498 ChemDiv3_001144 Clc1ccc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCCCCC3)nc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D23 mock treatment 106760.0 -16000.0 -0.26 133960.0 15100.0 0.24 -0.0173 -0.0483 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 D24 mock treatment 100920.0 -21900.0 -0.36 107120.0 -11800.0 -0.19 -0.3879 -0.9532 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E01 compound treatment 86000.0 -36800.0 -0.61 83840.0 -35000.0 -0.56 -0.8245 -0.9991 3020664 ChemDiv3_001145 NN(CCC#N)C1=NS(=O)(=O)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E02 compound treatment 119920.0 -2890.0 -0.05 125520.0 6650.0 0.11 0.0412 0.3547 1565298 ChemDiv3_001146 Cc1ccc(OCC(=O)NC2CCS(=O)(=O)C2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E03 compound treatment 123560.0 751.0 0.01 116440.0 -2430.0 -0.04 -0.0186 -0.4579 1023964 ChemDiv3_001147 O=c1cc(ss1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E04 compound treatment 125520.0 2710.0 0.04 112720.0 -6150.0 -0.1 -0.0377 -0.3496 1128679 ChemDiv3_001148 OC(=O)C1CCCN(C1)S(=O)(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E05 compound treatment 40800.0 -82000.0 -1.35 37280.0 -81600.0 -1.3 -1.8768 -0.9998 3020666 ChemDiv3_001149 NC(=O)c1cccc(/N=C/c2cccc(Cl)c2Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E06 compound treatment 84560.0 -38200.0 -0.63 85760.0 -33100.0 -0.53 -0.8196 -0.996 1433984 ChemDiv3_001150 COC(=O)C1=C(C)NC2=C(C1c3ccccc3)C(=O)CC(C2)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E07 compound treatment 43920.0 -78900.0 -1.3 35720.0 -83200.0 -1.33 -1.858 -1.0 1622867 ChemDiv3_001151 CCN1C(=O)c2cccc3c(ccc1c23)S(=O)(=O)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E08 compound treatment 12880.0 -110000.0 -1.81 20560.0 -98300.0 -1.57 -2.3911 -0.9973 3118752 ChemDiv3_001152 CC(C)c1cc(C(C)C)c(N)c(c1)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E09 compound treatment 138560.0 15800.0 0.26 96400.0 -22500.0 -0.36 -0.0694 -0.1568 3020668 ChemDiv3_001153 CC(C)OC(=O)CCN1C(=O)/C(=C/c2ccccc2)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E10 compound treatment 146320.0 23500.0 0.39 132360.0 13500.0 0.21 0.4265 0.9612 1484844 ChemDiv3_001154 CC(=O)Nc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E11 compound treatment 132120.0 9310.0 0.15 130680.0 11800.0 0.19 0.2418 0.9949 1314682 ChemDiv3_001155 O=C(Nc1nccs1)c2cccc(c2)S(=O)(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E12 compound treatment 42480.0 -80300.0 -1.33 41400.0 -77500.0 -1.23 -1.8107 -0.9994 3020722 ChemDiv3_001156 COc1cc(/C=C\2/S/C(=N\c3cc(C)cc(C)c3)/NC2=O)cc(Br)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E13 compound treatment 105360.0 -17400.0 -0.29 90120.0 -28800.0 -0.46 -0.5277 -0.975 1326481 ChemDiv3_001157 Sc1nnc(CCn2c3ccccc3c4ccccc24)n1CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E14 compound treatment 168680.0 45900.0 0.76 174560.0 55700.0 0.89 1.1631 0.9969 3020724 ChemDiv3_001158 Cc1ccc(cc1)c2nnc(SCC=C)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E15 compound treatment 118440.0 -4370.0 -0.07 118520.0 -351.0 -0.01 -0.055 -0.7597 1337418 ChemDiv3_001159 O=S(=O)(N1CCCCC1)c2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E16 compound treatment 57280.0 -65500.0 -1.08 76560.0 -42300.0 -0.67 -1.2417 -0.9741 3020725 ChemDiv3_001160 CN(/N=C/c1cccc(Br)c1)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E17 compound treatment 92280.0 -30500.0 -0.5 90560.0 -28300.0 -0.45 -0.6754 -0.9985 1502789 ChemDiv3_001161 Cc1ccc(cc1)C(=O)Nc2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E18 compound treatment 8440.0 -114000.0 -1.89 8640.0 -110000.0 -1.76 -2.5773 -0.9994 1562439 ChemDiv3_001162 OCCc1c(c2ccccc2)n(Cc3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E19 compound treatment 33440.0 -89400.0 -1.48 15680.0 -103000.0 -1.64 -2.2061 -0.9985 1347662 ChemDiv3_001163 CC(NC(=O)COc1ccccc1C(C)(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E20 compound treatment 97240.0 -25600.0 -0.42 99480.0 -19400.0 -0.31 -0.517 -0.9883 3118753 ChemDiv3_001164 OC(=O)/C=C/C(=O)Nc1sc2CCCc2c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E21 compound treatment 20600.0 -102000.0 -1.69 22880.0 -96000.0 -1.53 -2.2749 -0.9988 1411190 ChemDiv3_001165 COC(=O)C1=C(C)NC(=C(C1c2ccc(cc2)C(C)C)C(=O)OC)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E22 compound treatment 58000.0 -64800.0 -1.07 59840.0 -59000.0 -0.94 -1.4218 -0.998 3118754 ChemDiv3_001166 COc1ccc(/C=C/C(=O)Nc2ccc(N3CCOCC3)c(Cl)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E23 mock treatment 140320.0 17500.0 0.29 122400.0 3530.0 0.06 0.2442 0.8291 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 E24 mock treatment 101640.0 -21200.0 -0.35 95880.0 -23000.0 -0.37 -0.5062 -0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F01 compound treatment 8520.0 -114000.0 -1.89 10160.0 -109000.0 -1.73 -2.5592 -0.9991 1523805 ChemDiv3_001167 Clc1ccc(cc1Cl)c2csc(NC(=O)C3CC3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F02 compound treatment 105720.0 -17100.0 -0.28 108560.0 -10300.0 -0.16 -0.3157 -0.9669 1457223 ChemDiv3_001168 COc1ccccc1NC(=O)CSc2nc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F03 compound treatment 142720.0 19900.0 0.33 139280.0 20400.0 0.33 0.4624 1.0 1694096 ChemDiv3_001169 Cc1nc2cc(NC(=O)c3ccc(cc3)N4C(=O)CCC4=O)ccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F04 compound treatment 26080.0 -96700.0 -1.6 16480.0 -102000.0 -1.63 -2.283 -0.9999 1719103 ChemDiv3_001170 CCC1(CC)Cc2ccccc2-c3nc4SCCn4c(=O)c31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F05 compound treatment 133040.0 10200.0 0.17 140160.0 21300.0 0.34 0.3594 0.9481 1784397 ChemDiv3_001171 CCCCc1c(O)nc(SCCC(=O)O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F06 compound treatment 173320.0 50500.0 0.83 176880.0 58000.0 0.92 1.2434 0.9987 3118755 ChemDiv3_001172 COc1cc(C=C2C(=O)NC(=S)NC2=O)ccc1OCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F07 compound treatment 37160.0 -85600.0 -1.41 29920.0 -89000.0 -1.42 -2.0022 -1.0 1922655 ChemDiv3_001173 Cc1ccc(cc1)N2C(=O)/C(=C/C=C/c3ccccc3)/SC2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F08 compound treatment 90960.0 -31800.0 -0.53 111160.0 -7710.0 -0.12 -0.4587 -0.8495 1328915 ChemDiv3_001174 COc1cccc(c1)N2C(=O)CC(SCC(=O)Nc3ccc4ccccc4c3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F09 compound treatment 163840.0 41000.0 0.68 152160.0 33300.0 0.53 0.8541 0.9927 1522826 ChemDiv3_001175 Cc1ccc2n(C)cc(C(=O)O)c(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F10 compound treatment 175160.0 52400.0 0.86 173840.0 55000.0 0.88 1.2306 1.0 3118902 ChemDiv3_001176 O=C(COC(=O)c1cccs1)c2ccc3OCCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F11 compound treatment 139800.0 17000.0 0.28 141960.0 23100.0 0.37 0.4585 0.991 3118903 ChemDiv3_001177 Cc1cc(C)c(C2=NON3N(C(=O)c4cccs4)c5ccccc5N32)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F12 compound treatment 163800.0 41000.0 0.68 184240.0 65400.0 1.04 1.2152 0.9782 1311807 ChemDiv3_001178 Cc1noc(n1)c2ccccc2OC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F13 compound treatment 163000.0 40200.0 0.66 162640.0 43800.0 0.7 0.9624 0.9997 3020393 ChemDiv3_001179 CCOC(=O)c1cc(no1)c2cc(OC)ccc2OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F14 compound treatment 169200.0 46400.0 0.77 184800.0 65900.0 1.05 1.2845 0.9879 1637396 ChemDiv3_001180 COc1nc(C)nc(NCC=C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F15 compound treatment 13120.0 -110000.0 -1.81 12280.0 -107000.0 -1.7 -2.4816 -0.9995 3118904 ChemDiv3_001181 Cc1ccc(cc1)C2C(=C(Oc3ccccc23)c4cccs4)C=C5C(=O)NC(=O)NC5=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F16 compound treatment 129680.0 6870.0 0.11 134840.0 16000.0 0.25 0.2602 0.9337 1442359 ChemDiv3_001182 COc1ccc(OCC(O)Cn2nc(C)cc2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F17 compound treatment 61040.0 -61800.0 -1.02 61240.0 -57600.0 -0.92 -1.3705 -0.9986 3118905 ChemDiv3_001183 CN(C)c1ccc(N/C=C/2\N=C(OC2=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F18 compound treatment 164000.0 41200.0 0.68 186400.0 67500.0 1.08 1.2419 0.9755 1362058 ChemDiv3_001184 COc1cccc(CC(=O)Nn2c(C)nc3ccccc3c2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F19 compound treatment 168680.0 45900.0 0.76 169280.0 50400.0 0.8 1.1035 0.9996 3118906 ChemDiv3_001185 C1CCc2c(C1)sc3ncn4nc(nc4c23)c5cccnc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F20 compound treatment 116720.0 -6090.0 -0.1 132440.0 13600.0 0.22 0.0819 0.3432 1616159 ChemDiv3_001186 Cc1ccc(CNC(=O)C2c3ccccc3Oc4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F21 compound treatment 148840.0 26000.0 0.43 135720.0 16800.0 0.27 0.4937 0.9744 1782607 ChemDiv3_001187 CCC(CC(C)(C)O)c1n[nH]c(=S)n1CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F22 compound treatment 96720.0 -26100.0 -0.43 118200.0 -671.0 -0.01 -0.3121 -0.7244 3118907 ChemDiv3_001188 O=C(CSC1=NC(=O)C(C(=O)N1)c2ccccc2)NC3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F23 mock treatment 128040.0 5230.0 0.09 128760.0 9890.0 0.16 0.1725 0.9599 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 F24 mock treatment 99880.0 -22900.0 -0.38 97480.0 -21400.0 -0.34 -0.5087 -0.9986 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G01 compound treatment 118960.0 -3850.0 -0.06 123120.0 4250.0 0.07 0.003 0.0319 3020400 ChemDiv3_001189 C=CCn1c(n[nH]c1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G02 compound treatment 59640.0 -63200.0 -1.04 53040.0 -65800.0 -1.05 -1.4793 -1.0 1285595 ChemDiv3_001190 CN(C)S(=O)(=O)c1ccc(cc1)C(=O)Nc2nc-3c(CCc4ccccc34)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G03 compound treatment 135800.0 13000.0 0.21 147800.0 28900.0 0.46 0.4777 0.9394 1230309 ChemDiv3_001191 C[N+]1(CCC2CC1)C(=C)C2(O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G04 compound treatment 65800.0 -57000.0 -0.94 71280.0 -47600.0 -0.76 -1.2018 -0.9943 3118908 ChemDiv3_001192 COc1ccc2c(C)cc(Sc3nnnn3c4ccccc4)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G05 compound treatment 47240.0 -75600.0 -1.25 41640.0 -77200.0 -1.23 -1.7525 -1.0 3020403 ChemDiv3_001193 Cc1ccc(/N=C\2/C(=O)Nc3ccccc23)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G06 compound treatment 106920.0 -15900.0 -0.26 107720.0 -11200.0 -0.18 -0.3111 -0.982 1391577 ChemDiv3_001194 COC(=O)C1=C(C)NC2=C(C1c3ccccc3OC(C)C)C(=O)CC(C2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G07 compound treatment 140760.0 18000.0 0.3 147120.0 28200.0 0.45 0.5279 0.9794 1779181 ChemDiv3_001195 Cc1cc(=O)[nH]c(SC(C(=O)O)c2ccccc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G08 compound treatment 45160.0 -77600.0 -1.28 40680.0 -78200.0 -1.25 -1.7876 -0.9999 1705952 ChemDiv3_001196 O=C(C(Sc1nc2ccccc2[nH]1)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G09 compound treatment 141480.0 18700.0 0.31 147640.0 28800.0 0.46 0.5422 0.9813 3020442 ChemDiv3_001197 COc1ccc(/C=N/N2C(=O)/C(=C/c3ccc(OC)cc3)/SC2=S)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G10 compound treatment 120760.0 -2050.0 -0.03 132640.0 13800.0 0.22 0.1313 0.5912 1503189 ChemDiv3_001198 CNC(=O)c1ccc2nc(N)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G11 compound treatment 154000.0 31200.0 0.51 166080.0 47200.0 0.75 0.8961 0.9829 1316072 ChemDiv3_001199 O=S(=O)(N1CCCC1)c2cccc(c2)c3nnc(o3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G12 compound treatment 15280.0 -108000.0 -1.78 16400.0 -102000.0 -1.63 -2.41 -0.9991 3118909 ChemDiv3_001200 Cc1cc(/C=C/2\SC(=O)NC2=O)c(C)n1c3cc(C)cc(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G13 compound treatment 156280.0 33500.0 0.55 165400.0 46500.0 0.74 0.9151 0.9895 3020445 ChemDiv3_001201 CC(=C)Cn1c(SCC(=O)O)nnc1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G14 compound treatment 152440.0 29600.0 0.49 147520.0 28600.0 0.46 0.6687 0.9994 3118910 ChemDiv3_001202 Cc1ccc(cc1)c2nnc(SC(=O)OCc3ccccc3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G15 compound treatment 114240.0 -8570.0 -0.14 133920.0 15000.0 0.24 0.0696 0.2499 3118911 ChemDiv3_001203 COc1ccc(cc1)n2cnc3cc(/N=C/c4nc5ccccc5n4C)ccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G16 compound treatment 116960.0 -5850.0 -0.1 127000.0 8130.0 0.13 0.0233 0.1445 3020449 ChemDiv3_001204 CN(/N=C/c1ccc(C)cc1)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G17 compound treatment 10360.0 -112000.0 -1.86 18000.0 -101000.0 -1.61 -2.4494 -0.9974 3118912 ChemDiv3_001205 CCCCC(=O)/C=C/n1c(=S)oc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G18 compound treatment 10640.0 -112000.0 -1.85 10760.0 -108000.0 -1.72 -2.5277 -0.9994 3020450 ChemDiv3_001206 CNCCc1c(c2ccccc2)n(c3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G19 compound treatment 45640.0 -77200.0 -1.27 69120.0 -49800.0 -0.79 -1.4615 -0.974 1598116 ChemDiv3_001207 CC(C)(C)c1ccccc1OCC(=O)Nc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G20 compound treatment 145080.0 22300.0 0.37 154920.0 36000.0 0.57 0.6662 0.9767 1411248 ChemDiv3_001208 CC(C)(C)OC(=O)C1=C(N)OC2=C(C(=O)CC(C)(C)C2)C31C(=O)Nc4ccccc43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G21 compound treatment 149480.0 26700.0 0.44 160800.0 41900.0 0.67 0.7839 0.9795 1864191 ChemDiv3_001209 CCC(Sc1n[nH]c(=O)[nH]c1=O)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G22 compound treatment 141800.0 19000.0 0.31 148640.0 29800.0 0.47 0.5572 0.9798 3020455 ChemDiv3_001210 O=C/1N(Cc2ccccc2)C(=S)S\C1=C/c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G23 mock treatment 114640.0 -8170.0 -0.13 123160.0 4290.0 0.07 -0.047 -0.311 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 G24 mock treatment 122120.0 -689.0 -0.01 94720.0 -24200.0 -0.38 -0.2802 -0.7277 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H01 compound treatment 43320.0 -79500.0 -1.31 39240.0 -79600.0 -1.27 -1.8253 -0.9999 3118913 ChemDiv3_001211 O=C(/C(=C/1\Nc2ccccc2S1)/C#N)c3ccc(cc3)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H02 compound treatment 126000.0 3190.0 0.05 120960.0 2090.0 0.03 0.0608 0.9755 3020457 ChemDiv3_001212 FC(F)(F)c1cccc(c1)N2C(=O)CC(C3CCCO3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H03 compound treatment 79520.0 -43300.0 -0.71 77600.0 -41300.0 -0.66 -0.9704 -0.9991 1133915 ChemDiv3_001213 CC1CCc2nc(NC(=O)c3ccc(Cc4ccccc4)cc3)sc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H04 compound treatment 149520.0 26700.0 0.44 151960.0 33100.0 0.53 0.6847 0.996 1679724 ChemDiv3_001214 OC(=O)CCSc1nc2ccccc2n1C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H05 compound treatment 137880.0 15100.0 0.25 97840.0 -21000.0 -0.34 -0.0611 -0.1464 3118914 ChemDiv3_001215 COc1ccc(OC)c(N/C=C(\C#N)/c2nc(cs2)c3cc4ccccc4oc3=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H06 compound treatment 156920.0 34100.0 0.56 132040.0 13200.0 0.21 0.5466 0.9095 3020524 ChemDiv3_001216 Clc1ccc(SCCc2nc3ccccc3o2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H07 compound treatment 18960.0 -104000.0 -1.71 21840.0 -97000.0 -1.55 -2.3057 -0.9987 1413360 ChemDiv3_001217 Clc1ccc(SCC2=NN(C(=O)C2)c3nc4ccccc4s3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H08 compound treatment 12000.0 -111000.0 -1.83 13800.0 -105000.0 -1.67 -2.4776 -0.999 1533668 ChemDiv3_001218 Cc1ccc(SC2=NS(=O)(=O)c3ccccc23)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H09 compound treatment 95440.0 -27400.0 -0.45 102280.0 -16600.0 -0.26 -0.5064 -0.9675 3118915 ChemDiv3_001219 COc1ccc(OCCSc2nc3ccccc3s2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H10 compound treatment 141960.0 19200.0 0.32 141320.0 22400.0 0.36 0.4765 0.9981 1368307 ChemDiv3_001220 COc1ccc(cc1)C(=O)CSc2nc3cc(OC)ccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H11 compound treatment 165040.0 42200.0 0.7 187160.0 68300.0 1.09 1.2626 0.9768 1480108 ChemDiv3_001221 COc1cc(cc(OC)c1OC)C(=O)NCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H12 compound treatment 148840.0 26000.0 0.43 143000.0 24100.0 0.38 0.5758 0.9985 1571229 ChemDiv3_001222 COc1ccc(cc1)C(=O)CC(CC(=O)c2ccc(OC)cc2)C#Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H13 compound treatment 165080.0 42300.0 0.7 136960.0 18100.0 0.29 0.6973 0.9235 1449253 ChemDiv3_001223 CC(=O)Oc1ccc(cc1)N(C(=O)C)S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H14 compound treatment 168800.0 46000.0 0.76 167480.0 48600.0 0.77 1.0847 0.9999 3020527 ChemDiv3_001224 COc1nc(nc(C)c1Br)N(CC=C)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H15 compound treatment 157080.0 34300.0 0.57 177320.0 58400.0 0.93 1.0588 0.9714 1303506 ChemDiv3_001225 COc1ccc(CCn2c(C)nc(=O)c(c2C)c3ccccc3)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H16 compound treatment 164200.0 41400.0 0.68 178240.0 59400.0 0.95 1.1522 0.9872 1333831 ChemDiv3_001226 NS(=O)(=O)c1ccc(cc1)N2C(=O)C3CC=CCC3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H17 compound treatment 128560.0 5750.0 0.09 134120.0 15200.0 0.24 0.239 0.9159 3020529 ChemDiv3_001227 CCc1cc2c(=O)oc(nc2s1)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H18 compound treatment 157720.0 34900.0 0.58 160600.0 41700.0 0.67 0.8778 0.9975 1332696 ChemDiv3_001228 CCC(C)NC(=O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H19 compound treatment 96200.0 -26600.0 -0.44 121840.0 2970.0 0.05 -0.2771 -0.6273 1174891 ChemDiv3_001229 OC(=O)C1CC(=C(CC1C(=O)c2ccccc2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H20 compound treatment 153400.0 30600.0 0.5 155160.0 36300.0 0.58 0.7661 0.9977 1219244 ChemDiv3_001230 CCCNC(=O)N(C)c1nncnc1C(=O)NC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H21 compound treatment 152480.0 29700.0 0.49 144560.0 25700.0 0.41 0.6359 0.996 1493398 ChemDiv3_001231 O=C1N(CC2OCc3ccccc3CO2)C(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H22 compound treatment 60640.0 -62200.0 -1.03 70800.0 -48100.0 -0.77 -1.2674 -0.9896 1293274 ChemDiv3_001232 Nc1nc(CSc2nnc3c4ccccc4[nH]c3n2)cs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H23 mock treatment 139920.0 17100.0 0.28 137440.0 18600.0 0.3 0.409 0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 H24 mock treatment 104040.0 -18800.0 -0.31 81880.0 -37000.0 -0.59 -0.636 -0.9549 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I01 compound treatment 131320.0 8510.0 0.14 136080.0 17200.0 0.27 0.2933 0.9517 3119049 ChemDiv3_001233 CCn1c(n[nH]c1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I02 compound treatment 139680.0 16900.0 0.28 141040.0 22200.0 0.35 0.4468 0.9931 3020534 ChemDiv3_001234 Cc1nc(SCC(=O)O)c2c3CCCCc3sc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I03 compound treatment 108720.0 -14100.0 -0.23 92280.0 -26600.0 -0.42 -0.4641 -0.9601 1118354 ChemDiv3_001235 Cc1ccc(cc1)C(=O)Nc2ccc3OCCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I04 compound treatment 184640.0 61800.0 1.02 191280.0 72400.0 1.15 1.5378 0.9981 1277083 ChemDiv3_001236 CCOC(=O)c1[nH]cnc1C(=O)Nc2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I05 compound treatment 155160.0 32400.0 0.53 150640.0 31800.0 0.51 0.7357 0.9996 3119050 ChemDiv3_001237 COc1ccc(/C=N/n2cnc3n(C)c(=O)n(\N=C\c4ccc(OC)cc4)c(=O)c23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I06 compound treatment 27400.0 -95400.0 -1.57 29880.0 -89000.0 -1.42 -2.1166 -0.9986 3020597 ChemDiv3_001238 COC(=O)Sc1nnc(o1)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I07 compound treatment 157720.0 34900.0 0.58 186360.0 67500.0 1.08 1.1681 0.9572 3020599 ChemDiv3_001239 Cc1cc(=O)[nH]c(SCC(=O)N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I08 compound treatment 235800.0 113000.0 1.87 220760.0 102000.0 1.62 2.4672 0.9976 3119051 ChemDiv3_001240 Cc1ccc(/N=C(\NC(=S)N)/c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I09 compound treatment 81800.0 -41000.0 -0.68 87440.0 -31400.0 -0.5 -0.8329 -0.989 3020601 ChemDiv3_001241 CN1CCN(CC1)NC(=O)CCN2C(=O)/C(=C\c3ccccc3)/SC2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I10 compound treatment 13360.0 -109000.0 -1.81 21520.0 -97400.0 -1.55 -2.3747 -0.9971 3119052 ChemDiv3_001242 CN(C)c1cc[n+](cc1)C(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I11 compound treatment 33400.0 -89400.0 -1.48 32520.0 -86400.0 -1.38 -2.0168 -0.9994 3119053 ChemDiv3_001243 COc1ccccc1NC(=O)c/2cc3ccccc3o\c2=N/c4ccccc4F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I12 compound treatment 206320.0 83500.0 1.38 219880.0 101000.0 1.61 2.1132 0.997 1781772 ChemDiv3_001244 Cc1cc(/C=C(\C#N)/c2ccccc2)c(C)n1c3cc(C)cc(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I13 compound treatment 177600.0 54800.0 0.9 156360.0 37500.0 0.6 1.0621 0.9798 1709347 ChemDiv3_001245 COc1ccc(cc1OC)c2nnc(S)n2c3ccccc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I14 compound treatment 25400.0 -97400.0 -1.61 22200.0 -96700.0 -1.54 -2.2265 -0.9998 1417740 ChemDiv3_001246 OC(COc1cccc2cccnc12)Cn3c4ccccc4c5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I15 compound treatment 177920.0 55100.0 0.91 178600.0 59700.0 0.95 1.3164 0.9997 1639763 ChemDiv3_001247 CC(C)(C)c1ccc(Cn2c(=N)n(CC(=O)O)c3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I16 compound treatment 129480.0 6670.0 0.11 128960.0 10100.0 0.16 0.1916 0.983 3119054 ChemDiv3_001248 COc1ccc(CC/N=C/2\SCC(=O)N2Cc3ccccc3)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I17 compound treatment 106640.0 -16200.0 -0.27 114240.0 -4630.0 -0.07 -0.2409 -0.87 3020607 ChemDiv3_001249 Oc1ccccc1/C=N/N2C(=O)C3C4CC(C=C4)C3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I18 compound treatment 184240.0 61400.0 1.01 166680.0 47800.0 0.76 1.2559 0.9901 1913826 ChemDiv3_001250 COc1ccc(cc1)n2ccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I19 compound treatment 96400.0 -26400.0 -0.44 136520.0 17600.0 0.28 -0.1093 -0.2108 3119055 ChemDiv3_001251 CCN1C(=O)/C(=C/2\SC(=S)N(C2=O)c3cccc(Cl)c3)/c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I20 compound treatment 148200.0 25400.0 0.42 178080.0 59200.0 0.94 0.9637 0.9333 1707679 ChemDiv3_001252 Cc1ccc(Oc2ccccc2)c(NC(=O)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I21 compound treatment 153600.0 30800.0 0.51 157480.0 38600.0 0.62 0.7945 0.9955 1775109 ChemDiv3_001253 CC(C)n1c(=S)[nH]c2n(C)c(=O)[nH]c(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I22 compound treatment 57480.0 -65300.0 -1.08 60720.0 -58200.0 -0.93 -1.4179 -0.9972 3020611 ChemDiv3_001254 Oc1ccc(CN2CCCC2)c3cccnc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I23 mock treatment 151240.0 28400.0 0.47 162760.0 43900.0 0.7 0.8265 0.9812 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 I24 mock treatment 85720.0 -37100.0 -0.61 86040.0 -32800.0 -0.52 -0.8029 -0.9969 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J01 compound treatment 82520.0 -40300.0 -0.67 81360.0 -37500.0 -0.6 -0.893 -0.9986 3119056 ChemDiv3_001255 CN1/C(=C(\C#N)/C(=O)c2ccc(F)cc2)/Nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J02 compound treatment 163360.0 40600.0 0.67 152520.0 33600.0 0.54 0.8526 0.994 3020669 ChemDiv3_001256 COc1ccc(Br)cc1/C=C/C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J03 compound treatment 66640.0 -56200.0 -0.93 38880.0 -80000.0 -1.27 -1.5571 -0.9878 3119057 ChemDiv3_001257 CC1=C(C(c2ccccc2)n3c(=O)/c(=C/c4cccs4)/sc3=N1)C(=O)Nc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J04 compound treatment 185440.0 62600.0 1.03 215400.0 96500.0 1.54 1.819 0.9813 3020672 ChemDiv3_001258 Fc1ccccc1OCCSc2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J05 compound treatment 72120.0 -50700.0 -0.84 55920.0 -63000.0 -1.0 -1.3011 -0.9959 3119058 ChemDiv3_001259 FC(F)(F)c1cccc(N/C=C(/C#N)\c2nc(cs2)c3ccc4OCOc4c3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J06 compound treatment 138120.0 15300.0 0.25 148680.0 29800.0 0.48 0.5147 0.9564 3020674 ChemDiv3_001260 O=C/1N\C(=N/S(=O)(=O)c2ccccc2)\S\C1=C\c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J07 compound treatment 172160.0 49400.0 0.81 171000.0 52100.0 0.83 1.1635 1.0 3119059 ChemDiv3_001261 CC1(C)CC(=O)C(=CNC2CCCC2)C(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J08 compound treatment 166760.0 44000.0 0.73 187280.0 68400.0 1.09 1.284 0.9804 1223136 ChemDiv3_001262 OC(=O)CCC(=O)Nc1cccc(c1)c2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J09 compound treatment 162360.0 39600.0 0.65 162000.0 43100.0 0.69 0.9477 0.9997 1160808 ChemDiv3_001263 CC(=O)Oc1ccccc1C(=O)N2CCCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J10 compound treatment 51240.0 -71600.0 -1.18 53720.0 -65200.0 -1.04 -1.5696 -0.9979 1127019 ChemDiv3_001264 N=c1n(CC(=O)c2ccco2)c3ccccc3n1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J11 compound treatment 181760.0 59000.0 0.97 185280.0 66400.0 1.06 1.4365 0.9991 3020678 ChemDiv3_001265 O=C(CSc1nc2ccccc2s1)OCN3C(=O)c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J12 compound treatment 58920.0 -63900.0 -1.05 138520.0 19600.0 0.31 -0.5243 -0.4766 3119060 ChemDiv3_001266 C1C(=CC(=NN=C1c2cccs2)c3cccs3)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J13 compound treatment 166280.0 43500.0 0.72 171880.0 53000.0 0.84 1.1048 0.9967 1124209 ChemDiv3_001267 O=C(CCN1C(=O)c2ccccc2C1=O)Oc3ccc4c5CCCc5c(=O)oc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J14 compound treatment 173240.0 50400.0 0.83 185840.0 67000.0 1.07 1.3434 0.9924 3020681 ChemDiv3_001268 CCNc1nc(NCC)nc(OCCOC(=O)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J15 compound treatment 73880.0 -48900.0 -0.81 97160.0 -21700.0 -0.35 -0.8158 -0.9284 1222243 ChemDiv3_001269 COc1ccc(cc1OC)C2=CC(c3ccccc3)c4ccccc4O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J16 compound treatment 149000.0 26200.0 0.43 166160.0 47300.0 0.75 0.8387 0.9652 1443019 ChemDiv3_001270 O=C(Nc1ccc(cc1)N2CCCCC2)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J17 compound treatment 193080.0 70300.0 1.16 197520.0 78600.0 1.25 1.7066 0.9992 1518842 ChemDiv3_001271 CCOC(=O)c1cc2c3c4CCCCc4oc3cc(I)c2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J18 compound treatment 168200.0 45400.0 0.75 185400.0 66500.0 1.06 1.2796 0.9855 3020684 ChemDiv3_001272 FC(F)(F)c1ccccc1NC(=O)C2c3ccccc3Oc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J19 compound treatment 61880.0 -60900.0 -1.01 81160.0 -37700.0 -0.6 -1.1362 -0.9697 3119061 ChemDiv3_001273 Fc1ccc(/N=C/2\SC(CC(=O)N2CCc3ccccc3)C(=O)NCCc4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J20 compound treatment 117560.0 -5250.0 -0.09 131520.0 12600.0 0.2 0.0813 0.3705 1484388 ChemDiv3_001274 Cc1cccc(NC(=O)c2ccc(C)c(c2)S(=O)(=O)N3CCCC3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J21 compound treatment 131040.0 8230.0 0.14 160600.0 41700.0 0.67 0.5664 0.8343 3020364 ChemDiv3_001275 CN(C)c1ccc(/C=C(\C#N)/C(=C(C#N)C#N)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J22 compound treatment 151920.0 29100.0 0.48 165120.0 46200.0 0.74 0.861 0.9785 1381241 ChemDiv3_001276 Nc1ccccc1Nc2c(N)c(=O)oc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J23 mock treatment 136280.0 13500.0 0.22 136960.0 18100.0 0.29 0.3611 0.9918 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 J24 mock treatment 103400.0 -19400.0 -0.32 92960.0 -25900.0 -0.41 -0.5186 -0.9921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K01 compound treatment 8560.0 -114000.0 -1.89 9120.0 -110000.0 -1.75 -2.5705 -0.9993 3020366 ChemDiv3_001277 Oc1ccccc1N2C(=O)/C(=C/c3ccc(Br)cc3)/C=C2c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K02 compound treatment 153840.0 31000.0 0.51 152600.0 33700.0 0.54 0.7423 0.9997 3119062 ChemDiv3_001278 CCOC(=O)c1cnn(c1N)c2nc(C)cc(C)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K03 compound treatment 192320.0 69500.0 1.15 172960.0 54100.0 0.86 1.421 0.9901 1164643 ChemDiv3_001279 Cc1nn(c(C)c1Sc2n[nH]c(=O)[nH]c2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K04 compound treatment 28440.0 -94400.0 -1.56 34560.0 -84300.0 -1.34 -2.0517 -0.9973 3119063 ChemDiv3_001280 Cc1ccc2nc(Nc3ccccc3)nc(c4ccccc4)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K05 compound treatment 170000.0 47200.0 0.78 165960.0 47100.0 0.75 1.0815 0.9998 1371214 ChemDiv3_001281 CCOC(=O)c1cnn(c1NC(=O)c2ccccc2F)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K06 compound treatment 172560.0 49800.0 0.82 196080.0 77200.0 1.23 1.4509 0.9807 3020371 ChemDiv3_001282 COC(=O)C(C)Sc1nnc(o1)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K07 compound treatment 161040.0 38200.0 0.63 188320.0 69400.0 1.11 1.229 0.9645 3119064 ChemDiv3_001283 Cc1nc(cs1)c2c(oc3cc(O)ccc3c2=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K08 compound treatment 109680.0 -13100.0 -0.22 106320.0 -12600.0 -0.2 -0.2947 -0.9992 3020374 ChemDiv3_001284 Brc1ccc(cc1)n2c(nc(=S)c3CCCCc32)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K09 compound treatment 50080.0 -72700.0 -1.2 52840.0 -66000.0 -1.05 -1.5931 -0.9978 3119065 ChemDiv3_001285 CSc1nnc(c(=O)n1/N=C/c2c(O)ccc3ccccc23)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K10 compound treatment 12920.0 -110000.0 -1.81 14720.0 -104000.0 -1.66 -2.4565 -0.999 3020376 ChemDiv3_001286 CCN(CC)C(=O)[n+]1ccc(OC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K11 compound treatment 157760.0 35000.0 0.58 167520.0 48600.0 0.78 0.9562 0.9894 1516068 ChemDiv3_001287 CCCOC(=O)C1=C(C)N(CC)C(=O)NC1c2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K12 compound treatment 14320.0 -108000.0 -1.79 17000.0 -102000.0 -1.62 -2.4144 -0.9988 3119198 ChemDiv3_001288 CCOC(=O)c1ccc(cc1)n2c(C)cc(C=C3C(=O)NC(=S)NC3=O)c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K13 compound treatment 75360.0 -47400.0 -0.78 79080.0 -39800.0 -0.63 -1.0023 -0.9945 3119199 ChemDiv3_001289 Cc1ccc(/C=N/c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K14 compound treatment 133480.0 10700.0 0.18 107200.0 -11700.0 -0.19 -0.007 -0.0272 3020408 ChemDiv3_001290 COC(=O)C1=C(C)N=c2s/c(=C/c3ccc(OC)cc3)/c(=O)n2C1c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K15 compound treatment 24040.0 -98800.0 -1.63 26720.0 -92200.0 -1.47 -2.1914 -0.9986 1548396 ChemDiv3_001291 CC(C)(C)C(O)Cn1c(=N)n(CCN2CCCCC2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K16 compound treatment 181760.0 59000.0 0.97 174320.0 55400.0 0.88 1.313 0.9988 3020412 ChemDiv3_001292 CC1=NN(C(=O)c2ccc(Cl)cc2)C(C)(C)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K17 compound treatment 14200.0 -109000.0 -1.79 15720.0 -103000.0 -1.64 -2.4303 -0.9991 3119200 ChemDiv3_001293 Brc1cccc(c1)C2CC(=O)c3c(N2)ccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K18 compound treatment 185840.0 63000.0 1.04 192280.0 73400.0 1.17 1.5631 0.9983 1559376 ChemDiv3_001294 CCCCN1CCc2c([nH]c3c(C)cccc23)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K19 compound treatment 26960.0 -95800.0 -1.58 27800.0 -91100.0 -1.45 -2.1452 -0.9991 3119201 ChemDiv3_001295 CCN1C(=O)/C(=C/2\SC(=S)N(C2=O)c3ccc(OC)cc3)/c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K20 compound treatment 142440.0 19600.0 0.32 154960.0 36100.0 0.58 0.6359 0.9631 1381466 ChemDiv3_001296 COc1ccc(cc1)n2c(nc3cc4OCOc4cc23)c5ccc(Br)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K21 compound treatment 165040.0 42200.0 0.7 165880.0 47000.0 0.75 1.0227 0.9994 1048818 ChemDiv3_001297 O=C(Oc1ccccc1)C(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K22 compound treatment 142880.0 20100.0 0.33 143520.0 24600.0 0.39 0.5121 0.9964 1302006 ChemDiv3_001298 CCc1nc(C)cn1S(=O)(=O)c2cc(OC)ccc2OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K23 mock treatment 152640.0 29800.0 0.49 141320.0 22400.0 0.36 0.6012 0.9877 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 K24 mock treatment 144080.0 21300.0 0.35 138800.0 19900.0 0.32 0.4729 0.9987 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L01 compound treatment 94880.0 -27900.0 -0.46 97720.0 -21200.0 -0.34 -0.5644 -0.9882 3119202 ChemDiv3_001299 CN1/C(=C(\C#N)/C(=O)c2ccccc2NS(=O)(=O)c3ccc(C)cc3)/Nc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L02 compound treatment 161840.0 39000.0 0.64 169120.0 50200.0 0.8 1.0219 0.9942 1913204 ChemDiv3_001300 OC(=O)/C=C/c1ccc(o1)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L03 compound treatment 142880.0 20100.0 0.33 153280.0 34400.0 0.55 0.6221 0.9709 1267306 ChemDiv3_001301 Clc1ccc(OCC(=O)NCc2n[nH]c(=S)n2c3cccc(Cl)c3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L04 compound treatment 108400.0 -14400.0 -0.24 114880.0 -3990.0 -0.06 -0.2132 -0.8658 1204085 ChemDiv3_001302 O=C1CC(CC(=C1)NC2CCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L05 compound treatment 155920.0 33100.0 0.55 168120.0 49200.0 0.78 0.9415 0.9844 3119203 ChemDiv3_001303 Fc1ccccc1N/C=C(\C#N)/c2nc(cs2)c3cc4ccccc4oc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L06 compound treatment 140880.0 18100.0 0.3 156000.0 37100.0 0.59 0.6294 0.9497 3119204 ChemDiv3_001304 O=C/1N\C(=N\S(=O)(=O)c2ccccc2)\S\C1=C/3\C(=O)Nc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L07 compound treatment 161400.0 38600.0 0.64 236560.0 118000.0 1.88 1.7768 0.8969 3020464 ChemDiv3_001305 CC1(C)CC(=O)C(=CNCc2ccc(F)cc2)C(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L08 compound treatment 171960.0 49200.0 0.81 189920.0 71000.0 1.13 1.3744 0.9866 1301856 ChemDiv3_001306 OC(=O)c1ccc(CN2C(=O)c3ccc(cc3C2=O)C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L09 compound treatment 171760.0 49000.0 0.81 201960.0 83100.0 1.32 1.5078 0.9719 1358651 ChemDiv3_001307 OC1(N(CCc2ccccc2)C(=O)c3ccccc31)c4ncc[nH]4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L10 compound treatment 176840.0 54000.0 0.89 171640.0 52800.0 0.84 1.2254 0.9996 3119205 ChemDiv3_001308 O=C(CN1C2=NCCCN2c3ccccc13)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L11 compound treatment 166320.0 43500.0 0.72 224360.0 105000.0 1.68 1.6968 0.928 1633574 ChemDiv3_001309 CC1=C(C)CC(C(C1)C(=O)O)C(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L12 compound treatment 28360.0 -94400.0 -1.56 26840.0 -92000.0 -1.47 -2.1397 -0.9995 1136469 ChemDiv3_001310 Sc1nc2sc3CCCc3c2c(=O)n1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L13 compound treatment 167000.0 44200.0 0.73 182960.0 64100.0 1.02 1.2381 0.9864 1155907 ChemDiv3_001311 CC(C)CC(N1C(=O)c2ccccc2C1=O)C(=O)Oc3ccc4c5CCCc5c(=O)oc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L14 compound treatment 158200.0 35400.0 0.58 189680.0 70800.0 1.13 1.2111 0.953 1677666 ChemDiv3_001312 CCN(c1nc(C)cc(OC)n1)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L15 compound treatment 39600.0 -83200.0 -1.37 62600.0 -56300.0 -0.9 -1.6054 -0.9787 3119206 ChemDiv3_001313 COc1cc2cc(C)nc(Cc3cccc4ccccc34)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L16 compound treatment 205000.0 82200.0 1.36 186880.0 68000.0 1.08 1.7258 0.9938 3020469 ChemDiv3_001314 CCCOC(=O)Nc1cccc(c1)C(=O)OCCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L17 compound treatment 119960.0 -2850.0 -0.05 119440.0 569.0 0.01 -0.0268 -0.5605 3119207 ChemDiv3_001315 Cc1ccc(cc1)c2csc(NC(=O)/C=C/c3ccco3)c2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L18 compound treatment 174960.0 52200.0 0.86 179240.0 60400.0 0.96 1.2891 0.9985 1128259 ChemDiv3_001316 CCOc1ccc(NC(=O)C2c3ccccc3Oc4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L19 compound treatment 45360.0 -77400.0 -1.28 61800.0 -57100.0 -0.91 -1.5472 -0.9861 3119208 ChemDiv3_001317 CN/1C(=O)CC(S\C1=N\c2ccc(I)cc2)C(=O)NCCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L20 compound treatment 166840.0 44000.0 0.73 174840.0 56000.0 0.89 1.1447 0.9948 1229602 ChemDiv3_001318 Cc1ccc(cc1C(=O)Oc2cccc3cccnc23)S(=O)(=O)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L21 compound treatment 173880.0 51100.0 0.84 172400.0 53500.0 0.85 1.1994 1.0 1681096 ChemDiv3_001319 COc1cccc(C(O)c2nccn2C)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L22 compound treatment 134000.0 11200.0 0.18 131320.0 12400.0 0.2 0.2709 0.9994 1212845 ChemDiv3_001320 CCn1c(C)nc2c(=O)oc3ccccc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L23 mock treatment 140760.0 18000.0 0.3 147000.0 28100.0 0.45 0.5266 0.9798 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 L24 mock treatment 129680.0 6870.0 0.11 135080.0 16200.0 0.26 0.2629 0.9317 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M01 compound treatment 70600.0 -52200.0 -0.86 92160.0 -26700.0 -0.43 -0.9104 -0.9471 3119209 ChemDiv3_001321 O=C/1N(C2CCCCC2)C(=S)S\C1=C/c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M02 compound treatment 132040.0 9230.0 0.15 121560.0 2690.0 0.04 0.1381 0.8721 3119210 ChemDiv3_001322 COC(=O)CN1C(c2ccccc2)c3cc(C)ccc3N=C1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M03 compound treatment 90000.0 -32800.0 -0.54 79720.0 -39200.0 -0.62 -0.8242 -0.9975 3020541 ChemDiv3_001323 Clc1ccc(/C=C/2\SC(=O)N(Cc3ccccc3)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M04 compound treatment 50120.0 -72700.0 -1.2 56720.0 -62200.0 -0.99 -1.5489 -0.9955 3119211 ChemDiv3_001324 NNc1nc(c2ccccc2)c3cc(Cl)ccc3n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M05 compound treatment 165840.0 43000.0 0.71 188320.0 69400.0 1.11 1.285 0.977 3020543 ChemDiv3_001325 CC1=Nc2ccc(Br)cc2C(N1CC(=O)NN)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M06 compound treatment 198720.0 75900.0 1.25 200440.0 81600.0 1.3 1.8054 0.9998 1584812 ChemDiv3_001326 CC(C(Cc1cc(C)cc(C)c1)C(=O)O)C(=O)NCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M07 compound treatment 147560.0 24800.0 0.41 169360.0 50500.0 0.8 0.8579 0.9506 1680758 ChemDiv3_001327 CCOC(=O)C(C)Oc1ccc2c(=O)c(coc2c1)c3csc(C)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M08 compound treatment 138600.0 15800.0 0.26 138200.0 19300.0 0.31 0.4022 0.9965 3020614 ChemDiv3_001328 Cn1/c(=N/C(=O)c2ccc(F)cc2)/sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M09 compound treatment 173800.0 51000.0 0.84 202440.0 83600.0 1.33 1.537 0.9755 1701030 ChemDiv3_001329 C1OC(OCC12COC(OC2)c3cccnc3)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M10 compound treatment 111600.0 -11200.0 -0.19 154160.0 35300.0 0.56 0.2669 0.4507 1243322 ChemDiv3_001330 COC(=O)c1cc(ccc1Cl)N2C(=O)C3C4OC(C)(C=C4)C3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M11 compound treatment 161200.0 38400.0 0.63 170240.0 51400.0 0.82 1.0271 0.992 3119212 ChemDiv3_001331 CC(=O)N/C(=C\c1ccccc1)/C(=O)Nc2cccc(C#N)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M12 compound treatment 195920.0 73100.0 1.21 187800.0 68900.0 1.1 1.6302 0.9989 1297939 ChemDiv3_001332 OC(=O)c1cc(NC(=O)Cc2cccs2)cc(c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M13 compound treatment 26480.0 -96300.0 -1.59 17680.0 -101000.0 -1.61 -2.2648 -1.0 1112646 ChemDiv3_001333 Clc1ccc(cc1)C(=O)Nc2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M14 compound treatment 71720.0 -51100.0 -0.84 79240.0 -39600.0 -0.63 -1.043 -0.9899 1527595 ChemDiv3_001334 O=C1CSC(N1C2CCCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M15 compound treatment 127240.0 4430.0 0.07 147120.0 28200.0 0.45 0.3701 0.8113 1359293 ChemDiv3_001335 CCCn1c(=N)n(CC(O)c2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M16 compound treatment 167680.0 44900.0 0.74 177040.0 58200.0 0.93 1.1793 0.9938 1703127 ChemDiv3_001336 Cc1nn(C(CC(=O)O)C(=O)O)c(C)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M17 compound treatment 101160.0 -21600.0 -0.36 112320.0 -6550.0 -0.1 -0.3265 -0.877 3119213 ChemDiv3_001337 Cc1ccccc1C2CC(=O)c3c(N2)ccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M18 compound treatment 163440.0 40600.0 0.67 177800.0 58900.0 0.94 1.1384 0.9864 3020623 ChemDiv3_001338 CCCCN1C(=O)/C(=C\2/Sc3ccc(OC)cc3N2C)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M19 compound treatment 142120.0 19300.0 0.32 175160.0 56300.0 0.9 0.8598 0.903 1127450 ChemDiv3_001339 COC(=O)c1c(NC(=O)c2c(C)onc2c3ccccc3Cl)sc4CCCCc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M20 compound treatment 205160.0 82400.0 1.36 212200.0 93300.0 1.49 2.0131 0.999 1635195 ChemDiv3_001340 COc1ccc(NC(=O)Nc2c(SC)nsc2SC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M21 compound treatment 76480.0 -46300.0 -0.76 71960.0 -46900.0 -0.75 -1.0695 -0.9999 3119214 ChemDiv3_001341 Nc1ccc(cc1)C(=O)OCCCc2nc3cc4ccccc4cc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M22 compound treatment 116680.0 -6130.0 -0.1 122400.0 3530.0 0.06 -0.0318 -0.2744 1632781 ChemDiv3_001342 Cc1ccc(c(C)c1)S(=O)(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M23 mock treatment 153000.0 30200.0 0.5 122880.0 4010.0 0.06 0.3976 0.7913 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 M24 mock treatment 156760.0 34000.0 0.56 136320.0 17400.0 0.28 0.5929 0.9477 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N01 compound treatment 127240.0 4430.0 0.07 140560.0 21700.0 0.35 0.2962 0.8382 1638529 ChemDiv3_001343 COC(=O)C1=C(CCS1)NC(=O)c2ccccc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N02 compound treatment 159280.0 36500.0 0.6 178040.0 59200.0 0.94 1.0926 0.9765 1175429 ChemDiv3_001344 Cc1c(oc2ccccc12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N03 compound treatment 11080.0 -112000.0 -1.84 10960.0 -108000.0 -1.72 -2.5203 -0.9994 3119343 ChemDiv3_001345 CCOc1cccc(c1)S(=O)(=O)N=C2C=C(C(=O)C(=C2)C(C)(C)C)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N04 compound treatment 179800.0 57000.0 0.94 177280.0 58400.0 0.93 1.3235 1.0 3020687 ChemDiv3_001346 N/C(=N\O)/CSc1nc2ccccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N05 compound treatment 157080.0 34300.0 0.57 176800.0 57900.0 0.92 1.0529 0.9724 1691239 ChemDiv3_001347 CCOC(=O)C1CCCN(Cc2ccccc2)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N06 compound treatment 177480.0 54700.0 0.9 170680.0 51800.0 0.83 1.222 0.999 1225871 ChemDiv3_001348 COc1ccc(OCC(=O)N2CCN(CC2)S(=O)(=O)c3ccc(OC)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N07 compound treatment 128960.0 6150.0 0.1 126160.0 7290.0 0.12 0.1539 0.9977 3119344 ChemDiv3_001349 CCOC(=O)c1sc2nc[nH]c(=O)c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N08 compound treatment 165760.0 43000.0 0.71 191120.0 72200.0 1.15 1.3156 0.9729 1528087 ChemDiv3_001350 Cc1cc(C)nc(Nc2ncc(O)n2c3ccc(Cl)c(Cl)c3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N09 compound treatment 185400.0 62600.0 1.03 186520.0 67600.0 1.08 1.493 0.9998 1141041 ChemDiv3_001351 OC(=O)CCP(=O)(O)CN1CCCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N10 compound treatment 10800.0 -112000.0 -1.85 12440.0 -106000.0 -1.7 -2.5069 -0.9991 1699621 ChemDiv3_001352 Clc1ccc(cc1Cl)C(=O)Cn2c(=N)n(Cc3ccccc3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N11 compound treatment 139200.0 16400.0 0.27 202880.0 84000.0 1.34 1.1381 0.8332 3020690 ChemDiv3_001353 CCC1C(=O)NC(=NC1=O)SCC(=O)Nc2ccc(Br)cn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N12 compound treatment 152680.0 29900.0 0.49 136200.0 17300.0 0.28 0.544 0.9625 1287141 ChemDiv3_001354 CC(=O)Nc1ccc(cc1)C(=O)CSc2nc(C)cc(O)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N13 compound treatment 172280.0 49500.0 0.82 236600.0 118000.0 1.88 1.9043 0.9305 1716124 ChemDiv3_001355 Cc1cc(OC(=O)C2COc3ccccc3O2)cc(C)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N14 compound treatment 191120.0 68300.0 1.13 192480.0 73600.0 1.17 1.6269 0.9998 3119345 ChemDiv3_001356 CCN1OCN(C1=N)c2nc(nc(n2)N(C)C)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N15 compound treatment 87160.0 -35600.0 -0.59 95920.0 -23000.0 -0.37 -0.6748 -0.9738 3119346 ChemDiv3_001357 COc1ccc(cc1)c2cc3cc(OC)c(OC)cc3c(Cc4ccccc4)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N16 compound treatment 207720.0 84900.0 1.4 192400.0 73500.0 1.17 1.8198 0.996 1442772 ChemDiv3_001358 CCOC(=O)c1c[nH]c2c(C)c(Cl)ccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N17 compound treatment 173400.0 50600.0 0.84 191800.0 72900.0 1.16 1.4124 0.9868 3119347 ChemDiv3_001359 Cc1cc(C)c2cccc(NC(=S)NC(=O)/C=C/c3ccccc3)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N18 compound treatment 27880.0 -94900.0 -1.57 55920.0 -63000.0 -1.0 -1.8175 -0.9768 1476763 ChemDiv3_001360 CC1CC(C)CN(C1)C(=O)C2c3ccccc3Oc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N19 compound treatment 156480.0 33700.0 0.56 192320.0 73400.0 1.17 1.2208 0.942 1211865 ChemDiv3_001361 COc1ccc(cc1)N2C(=O)CC(SCC(=O)O)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N20 compound treatment 80440.0 -42400.0 -0.7 93520.0 -25400.0 -0.4 -0.7803 -0.966 1518987 ChemDiv3_001362 O=C(N1CCCc2ccccc12)c3cccc(c3)S(=O)(=O)NC4CCCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N21 compound treatment 135800.0 13000.0 0.21 152120.0 33200.0 0.53 0.5264 0.9207 1331290 ChemDiv3_001363 CC1=C(C(NC(=O)N1)c2ccccc2)C(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N22 compound treatment 117200.0 -5610.0 -0.09 101800.0 -17100.0 -0.27 -0.2579 -0.8972 1486835 ChemDiv3_001364 Cc1nc2c(=O)oc3ccccc3c2n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N23 mock treatment 131840.0 9030.0 0.15 132560.0 13700.0 0.22 0.2597 0.9828 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 N24 mock treatment 119480.0 -3330.0 -0.05 119560.0 689.0 0.01 -0.0311 -0.5549 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O01 compound treatment 15360.0 -107000.0 -1.77 13040.0 -106000.0 -1.69 -2.4469 -0.9997 1423808 ChemDiv3_001365 CCOc1ccc(cc1Br)C(=O)Nc2ccc(NC(=O)c3ccccc3)c(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O02 compound treatment 40760.0 -82000.0 -1.35 54360.0 -64500.0 -1.03 -1.6848 -0.9908 3119348 ChemDiv3_001366 CCN1C(=O)c2cccc3c(NC(=S)NC(=O)c4ccccc4)ccc1c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O03 compound treatment 151880.0 29100.0 0.48 168920.0 50000.0 0.8 0.9034 0.9704 3020430 ChemDiv3_001367 Cc1cccc(NC(=O)CCN2C(=O)/C(=C\c3ccccc3)/SC2=S)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O04 compound treatment 16640.0 -106000.0 -1.75 46400.0 -72500.0 -1.16 -2.056 -0.9795 1324540 ChemDiv3_001368 CCOc1ccc(NC(=O)NC2(CC3CC4CC(C3)C2)C4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O05 compound treatment 57680.0 -65100.0 -1.08 60400.0 -58500.0 -0.93 -1.4192 -0.9975 1278554 ChemDiv3_001369 Clc1cccc(c1)C(=O)NCC(=O)Nc2ccc(Br)cc2C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O06 compound treatment 201040.0 78200.0 1.29 196960.0 78100.0 1.24 1.7932 0.9998 1711492 ChemDiv3_001370 CN1N=C(C(NC(=O)C)C1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O07 compound treatment 65760.0 -57000.0 -0.94 62640.0 -56200.0 -0.9 -1.2996 -0.9997 1278126 ChemDiv3_001371 CC(C)Oc1ccc2c(=O)c(c(C)oc2c1)c3ccc4OCCOc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O08 compound treatment 39720.0 -83100.0 -1.37 50040.0 -68800.0 -1.1 -1.7456 -0.9939 3021156 ChemDiv3_001372 N(=c/1\scc(c2cccs2)n1c3ccccc3)\c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O09 compound treatment 19280.0 -104000.0 -1.71 19920.0 -99000.0 -1.58 -2.3236 -0.9992 3021157 ChemDiv3_001373 FC(F)(F)c1ccccc1/C=C/2\N=C(OC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O10 compound treatment 10960.0 -112000.0 -1.85 12200.0 -107000.0 -1.7 -2.5078 -0.9992 3021158 ChemDiv3_001374 COc1ccccc1NC(=O)/C=C\c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O11 compound treatment 18200.0 -105000.0 -1.73 16800.0 -102000.0 -1.63 -2.3714 -0.9996 3119349 ChemDiv3_001375 CCCCn1c(Cc2ccccc2)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O12 compound treatment 164400.0 41600.0 0.69 173440.0 54600.0 0.87 1.1005 0.9931 1533954 ChemDiv3_001376 OC(=O)c1cc(NC(=O)c2cccs2)cc(c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O13 compound treatment 190640.0 67800.0 1.12 205920.0 87000.0 1.39 1.7728 0.9943 1377349 ChemDiv3_001377 Brc1ccc2oc(=O)c(cc2c1)C(=O)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O14 compound treatment 198400.0 75600.0 1.25 182200.0 63300.0 1.01 1.5961 0.9945 3119350 ChemDiv3_001378 CCOC(=O)CC/1=NN(C(=O)\C1=C/c2cc(OC)c(OC)cc2OC)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O15 compound treatment 85800.0 -37000.0 -0.61 71120.0 -47800.0 -0.76 -0.9701 -0.9941 3021159 ChemDiv3_001379 CCn1c(/C=N/c2ccccc2)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O16 compound treatment 144840.0 22000.0 0.36 177400.0 58500.0 0.93 0.9168 0.9157 1912932 ChemDiv3_001380 CCOC(=O)C1CNN=C1C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O17 compound treatment 53320.0 -69500.0 -1.15 52160.0 -66700.0 -1.06 -1.5629 -0.9993 1144944 ChemDiv3_001381 CCOC(=O)c1ccc2nc(ccc2c1)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O18 compound treatment 72720.0 -50100.0 -0.83 88440.0 -30400.0 -0.49 -0.9276 -0.9677 3021160 ChemDiv3_001382 CCN1/C(=C\C(=S)CC)/Sc2ccc(Cl)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O19 compound treatment 186720.0 63900.0 1.05 195240.0 76400.0 1.22 1.6067 0.9975 1434944 ChemDiv3_001383 Brc1ccc(OCC(=O)NCC2CCCO2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O20 compound treatment 153760.0 31000.0 0.51 157400.0 38500.0 0.61 0.7955 0.9958 1002861 ChemDiv3_001384 CC(Oc1ccccc1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O21 compound treatment 109040.0 -13800.0 -0.23 120240.0 1370.0 0.02 -0.1453 -0.6363 3119351 ChemDiv3_001385 O=C(Nc1cc2c(ccc3ccccc32)oc1=O)/C=C/c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O22 compound treatment 67720.0 -55100.0 -0.91 65840.0 -53000.0 -0.85 -1.2407 -0.9993 3021161 ChemDiv3_001386 CCOC(=O)/C=C(\C)/Nc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O23 mock treatment 127360.0 4550.0 0.08 124000.0 5130.0 0.08 0.1109 0.9991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 O24 mock treatment 112880.0 -9930.0 -0.16 128080.0 9210.0 0.15 -0.0121 -0.055 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P01 compound treatment 39440.0 -83400.0 -1.38 34280.0 -84600.0 -1.35 -1.9265 -0.9999 1607061 ChemDiv3_001387 COC(=O)C1=C(CCS1)NC(=O)c2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P02 compound treatment 115480.0 -7330.0 -0.12 109800.0 -9070.0 -0.14 -0.1878 -0.9961 3021162 ChemDiv3_001388 CN1CNC(=NS(=O)(=O)c2ccc(NC(=O)C)cc2)NC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P03 compound treatment 99560.0 -23200.0 -0.38 92600.0 -26300.0 -0.42 -0.5675 -0.9991 1145842 ChemDiv3_001389 CCCCn1c(Br)nc2n(C)c(=O)[nH]c(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P04 compound treatment 131200.0 8390.0 0.14 143720.0 24800.0 0.4 0.378 0.9009 1326168 ChemDiv3_001390 CCOC(=O)c1[nH]c(C(=O)O)c(CC)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P05 compound treatment 8000.0 -115000.0 -1.9 8240.0 -111000.0 -1.76 -2.5869 -0.9994 3119352 ChemDiv3_001391 CC1=CC(=O)C=C(C)C1=NS(=O)(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P06 compound treatment 112520.0 -10300.0 -0.17 108200.0 -10700.0 -0.17 -0.2404 -1.0 1659137 ChemDiv3_001392 CC(C)CC(=O)N1CCN(Cc2ccc(Cl)cc2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P07 compound treatment 169400.0 46600.0 0.77 176240.0 57400.0 0.91 1.1904 0.9963 1602384 ChemDiv3_001393 COc1cccc(c1)C(=O)NCCN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P08 compound treatment 162720.0 39900.0 0.66 185800.0 66900.0 1.07 1.2202 0.9732 3119353 ChemDiv3_001394 CC1CCc2sc(NC(=O)C(Cc3ccccc3)Cc4ccccc4)c(C#N)c2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P09 compound treatment 6360.0 -116000.0 -1.92 6840.0 -112000.0 -1.79 -2.6219 -0.9993 3021163 ChemDiv3_001395 CCOC(=O)c1c(oc2ccc(O)c(CSCC(=O)Nc3ccccc3)c12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P10 compound treatment 23160.0 -99600.0 -1.64 20240.0 -98600.0 -1.57 -2.2747 -0.9997 3119354 ChemDiv3_001396 Cc1cccc(c1)C(=O)Sc2cccccc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P11 compound treatment 83040.0 -39800.0 -0.66 95960.0 -22900.0 -0.37 -0.7224 -0.9617 1345562 ChemDiv3_001397 Cc1ccc(o1)c2c(C#N)c(SCC=C)nc3CCCCc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P12 compound treatment 43400.0 -79400.0 -1.31 44520.0 -74400.0 -1.19 -1.7648 -0.9987 1469960 ChemDiv3_001398 CN1CCN(CCCN2C(SCC2=O)c3ccc(F)cc3)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P13 compound treatment 163920.0 41100.0 0.68 181840.0 63000.0 1.0 1.1895 0.9818 1737932 ChemDiv3_001399 COC(=O)COc1ccc2c(=O)c(coc2c1)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P14 compound treatment 167760.0 45000.0 0.74 193680.0 74800.0 1.19 1.3678 0.974 1405560 ChemDiv3_001400 Cc1ccc(OCC(O)CN2C(=O)NC(C)(C)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P15 compound treatment 85000.0 -37800.0 -0.62 127800.0 8930.0 0.14 -0.3407 -0.5322 1711766 ChemDiv3_001401 CCc1nc(cc2cc(OC)c(OC)cc12)c3ccc(OC)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P16 compound treatment 89800.0 -33000.0 -0.54 87640.0 -31200.0 -0.5 -0.7373 -0.999 3021164 ChemDiv3_001402 Cc1ccc(cc1C)S(=O)(=O)N2CCCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P17 compound treatment 91040.0 -31800.0 -0.52 76040.0 -42800.0 -0.68 -0.8535 -0.9915 1435290 ChemDiv3_001403 CC1(C)Cc2c(sc3ncn4nc(nc4c23)c5ccccc5)C(C)(C)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P18 compound treatment 118920.0 -3890.0 -0.06 122880.0 4010.0 0.06 -2.0E-4 -0.0023 1603940 ChemDiv3_001404 COc1ccccc1NC(=O)C2c3ccccc3Oc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P19 compound treatment 128680.0 5870.0 0.1 176160.0 57300.0 0.91 0.7142 0.7778 3119355 ChemDiv3_001405 CC(C)Oc1ccc(cc1)C2CC(=O)NNC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P20 compound treatment 76120.0 -46700.0 -0.77 89760.0 -29100.0 -0.46 -0.8731 -0.9705 1788078 ChemDiv3_001406 Cc1ccc(cc1S(=O)(=O)N2CCCC2)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P21 compound treatment 69800.0 -53000.0 -0.88 83720.0 -35200.0 -0.56 -1.0149 -0.9768 3021165 ChemDiv3_001407 O=C(NN1C(=O)/C(=C\c2cccnc2)/SC1=S)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P22 compound treatment 107000.0 -15800.0 -0.26 127760.0 8890.0 0.14 -0.0843 -0.2841 1314274 ChemDiv3_001408 COc1ccc(cc1)n2nc3ccc(NC(=O)c4ccc(cc4)c5ccccc5)cc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P23 mock treatment 104840.0 -18000.0 -0.3 98800.0 -20100.0 -0.32 -0.4359 -0.9993 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2004 P24 mock treatment 64720.0 -58100.0 -0.96 56080.0 -62800.0 -1.0 -1.3857 -0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A01 compound treatment 77200.0 -37000.0 -0.61 70280.0 -48100.0 -0.77 -0.9744 -0.9937 3118959 ChemDiv3_003873 COC(=O)C(CC(C)C)N1C=C(C(C(=C1)C(=O)OC)c2ccc(Br)cc2)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A02 compound treatment 97200.0 -17000.0 -0.28 77520.0 -40900.0 -0.65 -0.6593 -0.9294 3023755 ChemDiv3_003874 CN(C)c1ccc(cc1)n2cccc2C=C3C(=O)N(C)C(=S)N(C)C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A03 compound treatment 129480.0 15300.0 0.25 151800.0 33400.0 0.53 0.5546 0.9415 1344150 ChemDiv3_003875 CSc1nnc-2c(OC(C)Nc3ccccc32)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A04 compound treatment 152560.0 38300.0 0.63 164360.0 46000.0 0.73 0.9656 0.9973 3118960 ChemDiv3_003876 O=C(CSc1nnc(COc2ccccc2)o1)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A05 compound treatment 178880.0 64700.0 1.07 190640.0 72300.0 1.15 1.5689 0.9993 3023867 ChemDiv3_003877 CCc1ccc2NC(=O)/C(=C/3\SC(=N)NC3=O)/c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A06 compound treatment 7840.0 -106000.0 -1.76 9720.0 -109000.0 -1.73 -2.4665 -1.0 1867181 ChemDiv3_003878 CCOC(=O)c1c(C)n(Cc2ccccc2)c3ccc(OCC(O)CNC(C)(C)C)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A07 compound treatment 166720.0 52500.0 0.87 182600.0 64200.0 1.02 1.3364 0.9966 3118961 ChemDiv3_003879 CCc1ccc(/C=N/n2c(C)nnc2n3nc(C)cc3C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A08 compound treatment 16120.0 -98100.0 -1.62 12320.0 -106000.0 -1.69 -2.3406 -0.9998 1292139 ChemDiv3_003880 O=C(N1c2ccccc2Sc3ccccc13)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A09 compound treatment 117880.0 3650.0 0.06 118480.0 95.0 0.0 0.0437 0.7246 3119097 ChemDiv3_003881 CN1C(=O)/C(=C/2\S\C(=N/c3ccc(F)cc3)\NC2=O)/c4cc(Br)cc(C)c14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A10 compound treatment 177640.0 63400.0 1.05 201960.0 83600.0 1.33 1.6821 0.9929 3023868 ChemDiv3_003882 CCCn1c(C)cc(C)c(C#N)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A11 compound treatment 205040.0 90800.0 1.5 214520.0 96100.0 1.53 2.1434 0.9999 3023869 ChemDiv3_003883 CC(Cc1ccccc1)[n+]2[cH-]/c(=N\C(=O)N)/on2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A12 compound treatment 179200.0 65000.0 1.07 201800.0 83400.0 1.33 1.6985 0.9943 1249817 ChemDiv3_003884 COc1cccc(CN2CCN(CC2)C(=O)c3cccs3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A13 compound treatment 79160.0 -35100.0 -0.58 44840.0 -73500.0 -1.17 -1.2382 -0.9471 3119098 ChemDiv3_003885 Cc1ccc(Nc2nnc(c3ccc(C)c(c3)S(=O)(=O)NCC4CCCO4)c5ccccc25)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A14 compound treatment 8480.0 -106000.0 -1.75 8360.0 -110000.0 -1.75 -2.4744 -1.0 3023870 ChemDiv3_003886 C(Cc1c[nH]c2ccccc12)NCc3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A15 compound treatment 139840.0 25600.0 0.42 125400.0 7020.0 0.11 0.378 0.8644 1549146 ChemDiv3_003887 Clc1ccc(SCC(=O)Nc2ccc(cc2)c3nc4ncccc4o3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A16 compound treatment 193760.0 79500.0 1.31 196240.0 77900.0 1.24 1.8057 0.9996 3023871 ChemDiv3_003888 CCCN(CCC)C1=C(N(CC(=O)N)S(=O)(=O)c2ccccc12)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A17 compound treatment 101680.0 -12600.0 -0.21 103240.0 -15100.0 -0.24 -0.3172 -0.9971 1118860 ChemDiv3_003889 CCN(CC)CCC(=O)N1N=C(CC1c2ccc(OC)cc2)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A18 compound treatment 60400.0 -53800.0 -0.89 64480.0 -53900.0 -0.86 -1.2358 -0.9999 1173412 ChemDiv3_003890 Cc1cc(C)cc(Oc2coc3cc(OCC(=O)NCc4ccccc4)ccc3c2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A19 compound treatment 193680.0 79500.0 1.31 183640.0 65300.0 1.04 1.6628 0.9934 1387978 ChemDiv3_003891 CN(C)C1CS(=O)(=O)CC1N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A20 compound treatment 48560.0 -65700.0 -1.08 45920.0 -72500.0 -1.15 -1.5832 -0.9995 1867723 ChemDiv3_003892 COc1ccccc1COc2ccc3c4CCCCCc4c(=O)oc3c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A21 compound treatment 137240.0 23000.0 0.38 162760.0 44400.0 0.71 0.7687 0.9575 1361724 ChemDiv3_003893 O=C(NCc1ccccc1)NC2CCS(=O)(=O)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A22 compound treatment 7760.0 -106000.0 -1.76 9200.0 -109000.0 -1.74 -2.4733 -1.0 1233165 ChemDiv3_003894 Cc1oc(cc1COc2ccc3c(C)c(Cc4ccccc4)c(=O)oc3c2C)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A23 mock treatment 108400.0 -5830.0 -0.1 105720.0 -12700.0 -0.2 -0.2108 -0.9426 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 A24 mock treatment 59440.0 -54800.0 -0.9 54200.0 -64200.0 -1.02 -1.3629 -0.9981 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B01 compound treatment 145680.0 31500.0 0.52 137520.0 19100.0 0.3 0.5828 0.9679 3119099 ChemDiv3_003895 CN(/N=C/c1ccccc1)C2=NS(=O)(=O)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B02 compound treatment 83240.0 -31000.0 -0.51 81120.0 -37300.0 -0.59 -0.7817 -0.9972 3119100 ChemDiv3_003896 COC(=O)C1=C(C)N/C(=C/c2cc(C)n(c2C)c3ccc(OC)c(Cl)c3)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B03 compound treatment 21000.0 -93200.0 -1.54 26960.0 -91400.0 -1.46 -2.1186 -0.9996 3023872 ChemDiv3_003897 COc1cccc(C=C2C(=O)c3ccccc3C2=O)c1OC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B04 compound treatment 176000.0 61800.0 1.02 183280.0 64900.0 1.03 1.4524 1.0 3023873 ChemDiv3_003898 Cc1ccc(cc1)c2c[n+]([O-])c3CCCc3[n+]2[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B05 compound treatment 142720.0 28500.0 0.47 158720.0 40300.0 0.64 0.7871 0.9882 3119101 ChemDiv3_003899 O=c1[nH]c2ccccc2n1CCCSc3nc4ccccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B06 compound treatment 108400.0 -5830.0 -0.1 127560.0 9180.0 0.15 0.0354 0.202 1401658 ChemDiv3_003900 CCOC(=O)c1c(oc2ccc(OCC(=O)OC)cc12)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B07 compound treatment 124560.0 10300.0 0.17 156640.0 38300.0 0.61 0.5517 0.8714 1210771 ChemDiv3_003901 CC(C)Cn1c(=O)c2cc3c(=O)n(CC(C)C)c(=O)c3c(C(=O)c4ccc(Cl)cc4)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B08 compound treatment 50320.0 -63900.0 -1.05 51800.0 -66600.0 -1.06 -1.4964 -1.0 1511593 ChemDiv3_003902 CC1CCN(CC1)S(=O)(=O)c2ccc(NC(=O)c3ccc(cc3)C(C)(C)C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B09 compound treatment 34960.0 -79300.0 -1.31 10200.0 -108000.0 -1.72 -2.1445 -0.9907 1487762 ChemDiv3_003903 O=S(=O)(NCCC1(CC2CC3CC(C2)C1)C3)c4cccc5nsnc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B10 compound treatment 117240.0 3010.0 0.05 99000.0 -19400.0 -0.31 -0.1833 -0.5859 3023874 ChemDiv3_003904 COc1cc(/C=C\2/C(=N)N3C=CSC3=NC2=O)cc(OC)c1OCCOc4ccc(C)c(C)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B11 compound treatment 167920.0 53700.0 0.89 202920.0 84500.0 1.35 1.5794 0.9794 3119102 ChemDiv3_003905 CN(C)/C=N/c1c(C#N)cnn1c2ncnc3sc4CCCc4c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B12 compound treatment 136160.0 21900.0 0.36 121920.0 3540.0 0.06 0.2958 0.8074 3023875 ChemDiv3_003906 COc1ccc2N3C(=NC(=O)C(Cc4ccccc4)C3=O)Sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B13 compound treatment 174560.0 60300.0 1.0 188080.0 69700.0 1.11 1.4897 0.9985 1072961 ChemDiv3_003907 O=c1n(Cc2ccccc2)nc(c3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B14 compound treatment 10960.0 -103000.0 -1.7 11000.0 -107000.0 -1.71 -2.4157 -1.0 1739914 ChemDiv3_003908 Clc1ccc(cc1)S(=O)(=O)Nc2nc3ccccc3nc2NCCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B15 compound treatment 149680.0 35500.0 0.59 139840.0 21500.0 0.34 0.6556 0.9673 3023876 ChemDiv3_003909 C(Sc1nc2ccccc2[nH]1)/C=C/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B16 compound treatment 11280.0 -103000.0 -1.7 12560.0 -106000.0 -1.69 -2.3943 -1.0 1325550 ChemDiv3_003910 NC1=C(C#N)C(c2sc3ccccc3c2O1)c4ccccc4OC(=O)c5ccccc5Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B17 compound treatment 148120.0 33900.0 0.56 169920.0 51500.0 0.82 0.9764 0.9825 3023877 ChemDiv3_003911 CC(C)OC(=O)C1=c2s/c(=C\c3cccnc3)/c(=O)n2C(=C(C#N)C1c4cccnc4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B18 compound treatment 167960.0 53700.0 0.89 176240.0 57900.0 0.92 1.2792 0.9998 3119103 ChemDiv3_003912 COc1ccc(CN2C(=O)CC(Cc3ccc(C)cc3)C2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B19 compound treatment 90760.0 -23500.0 -0.39 59960.0 -58400.0 -0.93 -0.9324 -0.9245 1408601 ChemDiv3_003913 COc1ccc(CCNc2ncnc3sc4CCCCc4c23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B20 compound treatment 11200.0 -103000.0 -1.7 12120.0 -106000.0 -1.69 -2.4002 -1.0 3023878 ChemDiv3_003914 N=C1NC(=O)/C(=C\c2cc3ccccc3nc2N4CCCCC4)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B21 compound treatment 146040.0 31800.0 0.53 155120.0 36700.0 0.59 0.7853 0.9985 1543973 ChemDiv3_003915 COc1ccc2CNCCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B22 compound treatment 153520.0 39300.0 0.65 229080.0 111000.0 1.76 1.7062 0.9077 3119104 ChemDiv3_003916 CC1CCN(CN2CC(COc3ccccc3C)OC2=O)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B23 mock treatment 139360.0 25100.0 0.41 167760.0 49400.0 0.79 0.8498 0.9553 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 B24 mock treatment 128240.0 14000.0 0.23 123320.0 4940.0 0.08 0.2191 0.8971 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C01 compound treatment 154240.0 40000.0 0.66 157720.0 39300.0 0.63 0.9103 0.9997 3119105 ChemDiv3_003917 COC(=O)C1=CN(C=C(C1c2ccsc2)C(=O)OC)c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C02 compound treatment 154360.0 40100.0 0.66 147360.0 29000.0 0.46 0.795 0.9844 3023910 ChemDiv3_003918 Cn1c(=O)n(C)c2cc(/C=C/3\C(=O)NC(=S)N(CC=C)C3=O)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C03 compound treatment 165880.0 51700.0 0.85 161040.0 42700.0 0.68 1.0836 0.9937 3119106 ChemDiv3_003919 CSC1=N/C(=C\c2ccccc2C)/C(=O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C04 compound treatment 164360.0 50100.0 0.83 172520.0 54100.0 0.86 1.1953 0.9998 3119107 ChemDiv3_003920 COc1ccc(CCCc2nnc(SCC(=O)Nc3cc(F)ccc3C)o2)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C05 compound treatment 69360.0 -44900.0 -0.74 71000.0 -47400.0 -0.76 -1.0578 -1.0 3023911 ChemDiv3_003921 C=CCN1C(=O)/C(=C/2\S/C(=N\c3ccccc3)/N(C2=O)c4ccccc4)/c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C06 compound treatment 180440.0 66200.0 1.09 183040.0 64700.0 1.03 1.5015 0.9996 1871099 ChemDiv3_003922 Cc1cccc(c1)N2C(=O)CC(Sc3nccc(C)n3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C07 compound treatment 15400.0 -98800.0 -1.63 16160.0 -102000.0 -1.63 -2.3057 -1.0 3023912 ChemDiv3_003923 CSC1=N/C(=C\C=C\c2cccs2)/C(=O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C08 compound treatment 55840.0 -58400.0 -0.96 49240.0 -69100.0 -1.1 -1.4608 -0.9978 1871152 ChemDiv3_003924 O=C(Cc1cccs1)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C09 compound treatment 176000.0 61800.0 1.02 174000.0 55600.0 0.89 1.3478 0.9976 3023913 ChemDiv3_003925 CCSC1=N/C(=C\c2ccc(C)s2)/C(=O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C10 compound treatment 46480.0 -67800.0 -1.12 20720.0 -97700.0 -1.56 -1.8915 -0.9868 3119108 ChemDiv3_003926 CCCN1C(=O)/C(=C/c2ccc(o2)c3ccc(Cl)cc3)/C(=C(C#N)C1=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C11 compound treatment 154480.0 40300.0 0.66 169440.0 51100.0 0.81 1.0452 0.9949 3023914 ChemDiv3_003927 N=c1[cH-][n+](CCc2ccccc2)no1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C12 compound treatment 160400.0 46200.0 0.76 159000.0 40600.0 0.65 0.9967 0.9967 1216628 ChemDiv3_003928 CCOc1cc(CN2CCN(CC2)C(=O)COc3ccc(C)cc3)ccc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C13 compound treatment 38240.0 -76000.0 -1.25 44720.0 -73700.0 -1.17 -1.7172 -0.9995 3023915 ChemDiv3_003929 COc1ccc(cc1)c2nnc(Nc3cccc(c3)C(F)(F)F)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C14 compound treatment 125760.0 11500.0 0.19 122320.0 3940.0 0.06 0.1789 0.8929 3119109 ChemDiv3_003930 COc1cccc(CNCCc2c[nH]c3ccccc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C15 compound treatment 17600.0 -96600.0 -1.6 17360.0 -101000.0 -1.61 -2.2665 -1.0 1485768 ChemDiv3_003931 CCC(=O)NC(c1ccco1)c2cc(Cl)c3cccnc3c2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C16 compound treatment 155680.0 41500.0 0.68 163680.0 45300.0 0.72 0.9943 0.9996 1522564 ChemDiv3_003932 Cc1nc(NCCN2CCOCC2)c3sc4nc5CC(C)(C)OCc5cc4c3n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C17 compound treatment 152600.0 38400.0 0.63 166240.0 47900.0 0.76 0.9872 0.9957 3119239 ChemDiv3_003933 COc1ccc(cc1)C2CC(=NN2C(=O)CCN3CCOCC3)c4ccc(Br)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C18 compound treatment 72320.0 -41900.0 -0.69 43000.0 -75400.0 -1.2 -1.3388 -0.9656 1139781 ChemDiv3_003934 CC(C)COC(=O)c1ccc2NC(C3CC=CC3c2c1)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C19 compound treatment 168400.0 54200.0 0.89 168000.0 49600.0 0.79 1.1915 0.9981 1505314 ChemDiv3_003935 O=S1(=O)CCC(C1)N2C(=S)SC3CS(=O)(=O)C=C32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C20 compound treatment 156360.0 42100.0 0.7 152960.0 34600.0 0.55 0.8814 0.9934 1867708 ChemDiv3_003936 COc1cc(COc2ccc3c4CCCc4c(=O)oc3c2)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C21 compound treatment 192320.0 78100.0 1.29 176360.0 58000.0 0.92 1.5649 0.9867 1172275 ChemDiv3_003937 CC1(CCS(=O)(=O)C1)NC(=S)Nc2ccc(O)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C22 compound treatment 155280.0 41100.0 0.68 152000.0 33600.0 0.54 0.858 0.9932 1132860 ChemDiv3_003938 CN(C)C(=O)COc1cc2oc(=O)c3CCCc3c2cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C23 mock treatment 145560.0 31300.0 0.52 142760.0 24400.0 0.39 0.6404 0.9901 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 C24 mock treatment 120320.0 6090.0 0.1 97800.0 -20600.0 -0.33 -0.1609 -0.4689 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D01 compound treatment 132360.0 18100.0 0.3 117120.0 -1270.0 -0.02 0.1974 0.658 3023916 ChemDiv3_003939 O=S1(=O)N=C(N(CCC#N)/N=C/c2ccccc2)c3ccccc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D02 compound treatment 99440.0 -14800.0 -0.24 86520.0 -31900.0 -0.51 -0.5318 -0.9437 3119240 ChemDiv3_003940 COC(=O)C/1=C(C)NC(=O)\C1=C\c2ccc(CNS(=O)(=O)c3ccc(Cl)cc3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D03 compound treatment 43160.0 -71100.0 -1.17 35160.0 -83200.0 -1.33 -1.7675 -0.9981 3023917 ChemDiv3_003941 CCC(C)N1C(=O)S/C(=C/c2ccc3n(C)c(=O)n(C)c3c2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D04 compound treatment 149560.0 35300.0 0.58 186520.0 68100.0 1.09 1.1803 0.9575 3119241 ChemDiv3_003942 [O-][n+]1cc(c2ccc(F)cc2)[n+]([O-])c3CCCc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D05 compound treatment 49680.0 -64600.0 -1.07 50680.0 -67700.0 -1.08 -1.5165 -1.0 3119242 ChemDiv3_003943 CCC(Sc1nnnn1c2ccccc2)C(=O)Nc3sc4CCCCc4c3C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D06 compound treatment 173720.0 59500.0 0.98 188280.0 69900.0 1.11 1.4821 0.998 3023918 ChemDiv3_003944 CCCCc1c(O)nc(SCC(=O)N2CCCCC2)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D07 compound treatment 10680.0 -104000.0 -1.71 10160.0 -108000.0 -1.72 -2.4284 -1.0 3119243 ChemDiv3_003945 COc1ccccc1CC(=O)Nc2ccc(cc2)c3nc4ccccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D08 compound treatment 84880.0 -29400.0 -0.48 65200.0 -53200.0 -0.85 -0.942 -0.9648 3023919 ChemDiv3_003946 OC(Cn1c2ccccc2c3ccccc13)C[n+]4cccc5cccc(O)c45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D09 compound treatment 167680.0 53500.0 0.88 176920.0 58500.0 0.93 1.2836 0.9996 3119244 ChemDiv3_003947 Nc1nc(SCC(=O)NCc2ccco2)c(C#N)cc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D10 compound treatment 93120.0 -21100.0 -0.35 95560.0 -22800.0 -0.36 -0.5036 -0.9998 3119245 ChemDiv3_003948 COc1ccccc1N(C(=O)NCc2ccccc2)C3=NCC(C)S3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D11 compound treatment 85160.0 -29100.0 -0.48 75440.0 -42900.0 -0.68 -0.8233 -0.9849 1494926 ChemDiv3_003949 Cc1ccc(cc1)c2nnc(n3cnc4cc(C)c(C)cc34)c5ccccc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D12 compound treatment 94960.0 -19300.0 -0.32 92800.0 -25600.0 -0.41 -0.5133 -0.9925 1647264 ChemDiv3_003950 CCc1nc2oc(C(=O)c3ccccc3)c(N)c2c4CC(C)(C)OCc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D13 compound treatment 68360.0 -45900.0 -0.76 54960.0 -63400.0 -1.01 -1.2502 -0.9899 1516394 ChemDiv3_003951 Cc1nc(Oc2ccc(NC(=O)c3ccccc3)cc2)c4c5CCCc5sc4n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D14 compound treatment 94760.0 -19500.0 -0.32 94280.0 -24100.0 -0.38 -0.4989 -0.9961 1736266 ChemDiv3_003952 CCc1ccc(Nc2nc3ccccc3nc2NS(=O)(=O)c4ccc(C)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D15 compound treatment 172880.0 58700.0 0.97 160080.0 41700.0 0.66 1.1545 0.9831 1623664 ChemDiv3_003953 C(N1CCc2ccccc2C1)n3cnc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D16 compound treatment 161640.0 47400.0 0.78 142640.0 24300.0 0.39 0.8267 0.9471 1684726 ChemDiv3_003954 COc1ccccc1NC(=O)COc2ccc3oc4CCCCc4c3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D17 compound treatment 153080.0 38900.0 0.64 160640.0 42300.0 0.67 0.9297 0.9997 1574911 ChemDiv3_003955 NC1=C(C#N)C2(C(=O)N(CC=C)c3ccccc32)c4c(O1)c5ccccc5oc4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D18 compound treatment 166200.0 52000.0 0.86 167960.0 49600.0 0.79 1.1653 0.9992 1249386 ChemDiv3_003956 O=C1CC(Cc2ccccc2)C(=O)N1c3nccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D19 compound treatment 179040.0 64800.0 1.07 183120.0 64700.0 1.03 1.4861 0.9998 1153670 ChemDiv3_003957 Cc1sc2nc3c4ccccc4c(NCC5CCCO5)nn3c(=O)c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D20 compound treatment 140120.0 25900.0 0.43 165800.0 47400.0 0.76 0.8366 0.9636 3119246 ChemDiv3_003958 CC(=O)N1C(=N)S/C(=C/c2cc3ccccc3nc2Sc4ccccc4)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D21 compound treatment 71640.0 -42600.0 -0.7 60760.0 -57600.0 -0.92 -1.1466 -0.9913 1736305 ChemDiv3_003959 CC(C)COc1ccc2c3CCCCc3c(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D22 compound treatment 152560.0 38300.0 0.63 138240.0 19900.0 0.32 0.6712 0.9487 3023957 ChemDiv3_003960 CC1CCN(CN2CC(Cn3c4ccccc4c5ccccc35)OC2=O)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D23 mock treatment 152360.0 38100.0 0.63 155720.0 37300.0 0.6 0.8658 0.9996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 D24 mock treatment 125480.0 11300.0 0.19 98280.0 -20100.0 -0.32 -0.0953 -0.2572 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E01 compound treatment 125040.0 10800.0 0.18 119040.0 655.0 0.01 0.1336 0.7472 3119247 ChemDiv3_003961 COC(=O)CN1C=C(C(C(=C1)C(=O)OC)c2ccc(O)cc2)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E02 compound treatment 18000.0 -96200.0 -1.59 19080.0 -99300.0 -1.58 -2.2424 -1.0 3119248 ChemDiv3_003962 CCC(C)n1cc(/C=C/2\C(=O)NC(=S)N(CC=C)C2=O)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E03 compound treatment 105320.0 -8910.0 -0.15 121000.0 2620.0 0.04 -0.0745 -0.4875 3023958 ChemDiv3_003963 O=C/1N=C(S\C1=C/c2cccs2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E04 compound treatment 130760.0 16500.0 0.27 178640.0 60300.0 0.96 0.872 0.8734 3023959 ChemDiv3_003964 O=C(CSc1nnc(COc2ccccc2)o1)NCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E05 compound treatment 179800.0 65600.0 1.08 197960.0 79600.0 1.27 1.6622 0.9969 3119249 ChemDiv3_003965 CN/1C(=N)NC(=O)\C1=C\c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E06 compound treatment 112600.0 -1630.0 -0.03 119320.0 935.0 0.01 -0.0085 -0.276 1871115 ChemDiv3_003966 CC(C)(CO)NC(=O)c1sc2ccccc2c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E07 compound treatment 58080.0 -56200.0 -0.93 58680.0 -59700.0 -0.95 -1.3283 -0.9999 3023960 ChemDiv3_003967 C(Sc1nnc-2c(OC(Nc3ccccc32)/C=C/c4ccco4)n1)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E08 compound treatment 106360.0 -7870.0 -0.13 102800.0 -15600.0 -0.25 -0.2675 -0.9543 3119250 ChemDiv3_003968 Cc1ccc(SCc2cc(O)nc(SCC(=O)n3c4ccccc4c5ccccc35)n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E09 compound treatment 156960.0 42700.0 0.71 148200.0 29800.0 0.48 0.8348 0.9815 3023961 ChemDiv3_003969 CCSC1=N/C(=C\c2cccc(F)c2)/C(=O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E10 compound treatment 150120.0 35900.0 0.59 172240.0 53900.0 0.86 1.0259 0.9836 1156555 ChemDiv3_003970 CC1CCN(CC1)C(=O)CNS(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E11 compound treatment 174120.0 59900.0 0.99 172320.0 53900.0 0.86 1.3069 0.9976 1664682 ChemDiv3_003971 Cc1n[nH]c(C)c1N2C(=O)c3cccc4c(N)ccc(C2=O)c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E12 compound treatment 152760.0 38500.0 0.64 157360.0 39000.0 0.62 0.889 0.9999 1473240 ChemDiv3_003972 O=C(N1CCN(Cc2cccnc2)CC1)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E13 compound treatment 139120.0 24900.0 0.41 169960.0 51600.0 0.82 0.8718 0.9486 3119251 ChemDiv3_003973 CNS(=O)(=O)c1cc(ccc1C)c2nnc(Nc3ccc4OCOc4c3)c5ccccc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E14 compound treatment 123880.0 9650.0 0.16 129000.0 10600.0 0.17 0.2323 0.9995 1668191 ChemDiv3_003974 CCOc1ccc(CN(CCc2ccc3OCOc3c2)Cc4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E15 compound treatment 161240.0 47000.0 0.78 185480.0 67100.0 1.07 1.3049 0.9876 1243341 ChemDiv3_003975 COc1ccc2cc(C3CC(=NN3C(=O)c4ccco4)c5ccc(OC)c(OC)c5)c(Cl)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E16 compound treatment 12240.0 -102000.0 -1.68 13400.0 -105000.0 -1.67 -2.3737 -1.0 3023962 ChemDiv3_003976 Fc1ccc(Nc2nc3ccccc3nc2Nc4ccc(F)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E17 compound treatment 94960.0 -19300.0 -0.32 96200.0 -22200.0 -0.35 -0.475 -0.9986 1173393 ChemDiv3_003977 CC(C)N(C(=O)Cn1c2ccccc2c3nc4ccccc4nc13)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E18 compound treatment 164840.0 50600.0 0.84 173240.0 54900.0 0.87 1.209 0.9997 3023963 ChemDiv3_003978 OC(C#CCN1CCOCC1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E19 compound treatment 170760.0 56500.0 0.93 196160.0 77800.0 1.24 1.5364 0.9902 3119252 ChemDiv3_003979 CCN(CC)C(=S)SC1=CCS(=O)(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E20 compound treatment 93800.0 -20400.0 -0.34 96600.0 -21800.0 -0.35 -0.484 -0.9999 1158512 ChemDiv3_003980 COc1ccc2c(c1)c(=O)oc3cc(OC(C)C)ccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E21 compound treatment 164960.0 50700.0 0.84 166880.0 48500.0 0.77 1.1387 0.9992 3119253 ChemDiv3_003981 CC12CS(=O)(=O)CC2SC(=S)N1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E22 compound treatment 143560.0 29300.0 0.48 136440.0 18100.0 0.29 0.5458 0.9691 1357925 ChemDiv3_003982 CN(C)C(=O)COc1cc(C)cc2oc(=O)c3CCCCc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E23 mock treatment 131920.0 17700.0 0.29 143080.0 24700.0 0.39 0.4848 0.9892 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 E24 mock treatment 126080.0 11900.0 0.2 125760.0 7380.0 0.12 0.2214 0.9703 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F01 compound treatment 118800.0 4570.0 0.08 126840.0 8460.0 0.13 0.1486 0.9624 3023964 ChemDiv3_003983 CN1C(=O)/C(=C/c2ccc(o2)c3ccc(Cl)cc3)/C(=C(C#N)C1=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F02 compound treatment 169560.0 55300.0 0.91 150000.0 31600.0 0.5 1.0021 0.9607 3119382 ChemDiv3_003984 O=C(NC1=NCCS1)c2cc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F03 compound treatment 120000.0 5770.0 0.1 115040.0 -3350.0 -0.05 0.0297 0.2716 1627858 ChemDiv3_003985 CN(C)c1ccc2nc3C(=O)c4ccccc4C(=O)c3nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F04 compound treatment 168120.0 53900.0 0.89 177080.0 58700.0 0.94 1.2905 0.9997 3119383 ChemDiv3_003986 CC1=[N+]([O-])C(C)(C)[N+](=C1c2ccc(C)cc2)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F05 compound treatment 41160.0 -73100.0 -1.21 29840.0 -88500.0 -1.41 -1.8508 -0.9969 3119384 ChemDiv3_003987 COC(=O)c1ccc(NC(=O)CC2Sc3ccc(cc3NC2=O)C(F)(F)F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F06 compound treatment 185480.0 71300.0 1.18 186600.0 68200.0 1.09 1.6005 0.9992 3023965 ChemDiv3_003988 CC(C)Cc1c(O)nc(SCC(=O)NC(C)(C)C)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F07 compound treatment 11480.0 -103000.0 -1.7 12120.0 -106000.0 -1.69 -2.397 -1.0 3119385 ChemDiv3_003989 Cc1ccccc1OCC(=O)Nc2cccc(c2)c3nnc(o3)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F08 compound treatment 155160.0 40900.0 0.68 168640.0 50300.0 0.8 1.0441 0.9964 3023966 ChemDiv3_003990 COC(=O)c1c(C)c(=O)[nH]c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F09 compound treatment 44280.0 -70000.0 -1.15 62720.0 -55700.0 -0.89 -1.4438 -0.9915 1509397 ChemDiv3_003991 Fc1ccc(cc1)C(=O)Nc2ncnc3sc4CCCCCc4c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F10 compound treatment 106200.0 -8030.0 -0.13 67520.0 -50900.0 -0.81 -0.667 -0.8119 3023967 ChemDiv3_003992 FC(F)(F)C1(N=C(OC(=N1)c2ccccc2)N3CCCCC3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F11 compound treatment 183920.0 69700.0 1.15 186560.0 68200.0 1.09 1.5818 0.9996 1229183 ChemDiv3_003993 Cc1sc2nc3c4ccccc4c(NCCO)nn3c(=O)c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F12 compound treatment 182400.0 68200.0 1.13 140680.0 22300.0 0.36 1.047 0.8872 1299234 ChemDiv3_003994 COC(=O)c1c(N)n(CCc2ccccc2)c3nc4ccccc4nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F13 compound treatment 166440.0 52200.0 0.86 163760.0 45400.0 0.72 1.1208 0.9962 1319064 ChemDiv3_003995 Cc1ccc(Oc2nnc(c3cccs3)c4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F14 compound treatment 45240.0 -69000.0 -1.14 52120.0 -66300.0 -1.06 -1.5521 -0.9993 3119386 ChemDiv3_003996 Cc1cccc(N/C=C\2/C(=O)N(C(=O)c3ccccc23)c4ccccc4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F15 compound treatment 190880.0 76700.0 1.27 193560.0 75200.0 1.2 1.7419 0.9996 3023968 ChemDiv3_003997 Cn1nc(CC(=O)Nc2nc(cs2)c3ccccc3)c4ccccc4c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F16 compound treatment 62560.0 -51700.0 -0.85 81520.0 -36900.0 -0.59 -1.0186 -0.9835 3119387 ChemDiv3_003998 COc1ccc(/N=C/c2c(O)ccc3oc4CCCCc4c23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F17 compound treatment 176400.0 62200.0 1.03 178080.0 59700.0 0.95 1.3984 0.9993 1229320 ChemDiv3_003999 CCOC(=O)CN1C(=O)C2(C(=C(N)OC3=C2C(=O)CC(C)(C)C3)C(=O)OCC)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F18 compound treatment 149400.0 35200.0 0.58 134360.0 16000.0 0.25 0.5906 0.9316 1796400 ChemDiv3_004000 COc1ccc(CCn2cnc3sc4CCCCc4c3c2=N)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F19 compound treatment 52360.0 -61900.0 -1.02 52200.0 -66200.0 -1.05 -1.4681 -0.9999 1598055 ChemDiv3_004001 Cc1cc(C(=O)CSc2nnc3cc(C)c4ccccc4n23)c(C)n1Cc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F20 compound treatment 190400.0 76200.0 1.26 169040.0 50700.0 0.81 1.46 0.9771 3024019 ChemDiv3_004002 CC(=O)N1C(=N)S/C(=C/c2cc3ccc(C)cc3nc2O)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F21 compound treatment 169280.0 55100.0 0.91 204480.0 86100.0 1.37 1.6129 0.98 1409929 ChemDiv3_004003 Cn1nc(C(=O)O)c2ccccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F22 compound treatment 149800.0 35600.0 0.59 154120.0 35700.0 0.57 0.8179 0.9999 1387840 ChemDiv3_004004 CCOC(=O)Cc1c(C)nc(Cc2ccc(OC(C)C)cc2)nc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F23 mock treatment 131840.0 17600.0 0.29 131240.0 12900.0 0.2 0.3504 0.9853 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 F24 mock treatment 124520.0 10300.0 0.17 131040.0 12700.0 0.2 0.2627 0.9963 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G01 compound treatment 102080.0 -12200.0 -0.2 97480.0 -20900.0 -0.33 -0.3774 -0.9705 3119388 ChemDiv3_004005 COC(=O)C1=CN(C=C(C1c2ccccc2)C(=O)OC)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G02 compound treatment 14640.0 -99600.0 -1.64 16960.0 -101000.0 -1.62 -2.3055 -1.0 3024021 ChemDiv3_004006 Cc1cc(/C=C/2\C(=O)NC(=S)N(CC=C)C2=O)c(C)n1c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G03 compound treatment 135280.0 21100.0 0.35 130680.0 12300.0 0.2 0.3843 0.9633 3119389 ChemDiv3_004007 c1ccc2sc(nc2c1)c3cccc(n3)c4nc5ccccc5s4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G04 compound treatment 142320.0 28100.0 0.46 170320.0 51900.0 0.83 0.9132 0.9625 3119390 ChemDiv3_004008 COc1ccc(Cc2nnc(SCC(=O)Nc3ccc(OC)cc3)o2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G05 compound treatment 65400.0 -48800.0 -0.81 60600.0 -57800.0 -0.92 -1.2212 -0.9978 3024022 ChemDiv3_004009 COc1ccc(/C=C/C=N/n2c(SC)nnc2c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G06 compound treatment 159520.0 45300.0 0.75 161720.0 43300.0 0.69 1.017 0.9992 1871125 ChemDiv3_004010 Cc1c(C)c2ccccc2n1C(=O)CSc3nc4ccccc4s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G07 compound treatment 91440.0 -22800.0 -0.38 94040.0 -24300.0 -0.39 -0.5404 -0.9999 1673764 ChemDiv3_004011 CC(=O)N1C(Oc2nc(SCC=C)nnc2-c3ccccc13)c4ccc(o4)c5ccc(F)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G08 compound treatment 156440.0 42200.0 0.7 166320.0 47900.0 0.76 1.0329 0.9989 3119391 ChemDiv3_004012 COc1ccc(NC(=O)C2CC(=O)N=C(Nc3ccccc3)S2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G09 compound treatment 145880.0 31700.0 0.52 177360.0 59000.0 0.94 1.0341 0.9616 1613829 ChemDiv3_004013 CCSc1nnc(c(O)n1)c2ccccc2NC(=O)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G10 compound treatment 84680.0 -29600.0 -0.49 103280.0 -15100.0 -0.24 -0.5152 -0.947 1558726 ChemDiv3_004014 CC(C)(C)NC(=O)N1c2ccccc2Sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G11 compound treatment 159160.0 44900.0 0.74 146480.0 28100.0 0.45 0.8411 0.9708 3119392 ChemDiv3_004015 Cc1nn(C)c(C)c1NC(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G12 compound treatment 38880.0 -75400.0 -1.24 42120.0 -76300.0 -1.22 -1.739 -0.9999 1465103 ChemDiv3_004016 CCc1ccc(CN2CCN(Cc3cccc(OC)c3)CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G13 compound treatment 72040.0 -42200.0 -0.7 77280.0 -41100.0 -0.66 -0.9557 -0.9995 3119393 ChemDiv3_004017 CCNS(=O)(=O)c1cc(ccc1C)c2nnc(Nc3ccc(F)cc3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G14 compound treatment 154840.0 40600.0 0.67 154480.0 36100.0 0.58 0.8808 0.9971 1303056 ChemDiv3_004018 CC(C)(C)NC1=C(N(CC(=O)c2ccccc2)S(=O)(=O)c3ccccc13)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G15 compound treatment 164600.0 50400.0 0.83 165520.0 47100.0 0.75 1.1192 0.9987 1692964 ChemDiv3_004019 CCC(=O)N1N=C(CC1c2cc3cc(OC)ccc3nc2Cl)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G16 compound treatment 175720.0 61500.0 1.02 186120.0 67700.0 1.08 1.4811 0.9995 1699942 ChemDiv3_004020 Brc1ccc(cc1)C2NC(=O)c3ccccc3O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G17 compound treatment 163920.0 49700.0 0.82 182960.0 64600.0 1.03 1.3078 0.9937 3024023 ChemDiv3_004021 CC(=O)OC1CCS(=O)(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G18 compound treatment 14080.0 -100000.0 -1.65 19880.0 -98500.0 -1.57 -2.2792 -0.9997 3119394 ChemDiv3_004022 CCCc1n[nH]c2OC(=C(C#N)C(CCc3ccccc3)c12)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G19 compound treatment 162480.0 48300.0 0.8 171320.0 52900.0 0.84 1.1598 0.9996 3024024 ChemDiv3_004023 CC1(CCS(=O)(=O)C1)NC(=S)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G20 compound treatment 23120.0 -91100.0 -1.5 23360.0 -95000.0 -1.51 -2.1344 -1.0 1713974 ChemDiv3_004024 Oc1cc(OCC(=O)c2ccccc2)cc3oc(cc(=O)c13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G21 compound treatment 145520.0 31300.0 0.52 165480.0 47100.0 0.75 0.896 0.9834 1338699 ChemDiv3_004025 CCCCN(C1CCS(=O)(=O)C1)C(=O)Nc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G22 compound treatment 142840.0 28600.0 0.47 128760.0 10400.0 0.17 0.4509 0.9011 1306939 ChemDiv3_004026 Cc1c(OC(=O)c2ccco2)ccc3c4CCCc4c(=O)oc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G23 mock treatment 127120.0 12900.0 0.21 128480.0 10100.0 0.16 0.2642 0.9905 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 G24 mock treatment 96240.0 -18000.0 -0.3 98240.0 -20100.0 -0.32 -0.437 -0.9992 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H01 compound treatment 38880.0 -75400.0 -1.24 38480.0 -79900.0 -1.27 -1.7801 -0.9999 3119395 ChemDiv3_004027 CC(C)N1C(=O)S/C(=C/c2ccc(Sc3nc4ccccc4[nH]3)o2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H02 compound treatment 106400.0 -7830.0 -0.13 110520.0 -7870.0 -0.13 -0.18 -0.9999 3024025 ChemDiv3_004028 Cc1c(c2ccco2)[n+]([O-])c(c(C)[n+]1[O-])c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H03 compound treatment 8960.0 -105000.0 -1.74 9520.0 -109000.0 -1.74 -2.4557 -1.0 3119396 ChemDiv3_004029 C/C(=N\O)/CCc1oc2ccccc2c1c3ccc(C)o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H04 compound treatment 176600.0 62400.0 1.03 151720.0 33300.0 0.53 1.1037 0.9526 3024026 ChemDiv3_004030 CC1N(O)C(C)(C)[N+](=C1c2ccccc2)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H05 compound treatment 162480.0 48300.0 0.8 167240.0 48900.0 0.78 1.1138 0.9999 3024027 ChemDiv3_004031 CC(=O)N/C(=C\c1cccs1)/C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H06 compound treatment 159040.0 44800.0 0.74 166200.0 47800.0 0.76 1.0619 0.9999 3119397 ChemDiv3_004032 CCSc1nc(O)c(C(C)CC)c(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H07 compound treatment 129960.0 15700.0 0.26 139120.0 20700.0 0.33 0.4173 0.9929 1130593 ChemDiv3_004033 O=C(Cc1ccccc1)Nc2cccc(c2)S(=O)(=O)c3cccc(NC(=O)Cc4ccccc4)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H08 compound treatment 116080.0 1850.0 0.03 144360.0 26000.0 0.41 0.3143 0.7572 3024028 ChemDiv3_004034 CCOC(=O)c1nn(c(C#N)c1NC(=O)c2nn(CC)cc2Br)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H09 compound treatment 13600.0 -101000.0 -1.66 15240.0 -103000.0 -1.64 -2.3371 -1.0 1423488 ChemDiv3_004035 COc1cc2c(cc1NP(=O)(C)Oc3ccccc3)oc4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H10 compound treatment 157000.0 42800.0 0.71 156160.0 37800.0 0.6 0.925 0.9969 3024029 ChemDiv3_004036 COc1ccc(Cl)cc1NC2=NCC(C)S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H11 compound treatment 141880.0 27700.0 0.46 142760.0 24400.0 0.39 0.5975 0.9968 1247540 ChemDiv3_004037 CC1CCN(CC1)c2nn3c(=O)c4c(C)c(C)sc4nc3c5ccccc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H12 compound treatment 145680.0 31500.0 0.52 132400.0 14000.0 0.22 0.525 0.929 1685422 ChemDiv3_004038 CCOC(=O)c1c(N)n(C2CCCCC2)c3nc4ccccc4nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H13 compound treatment 16920.0 -97300.0 -1.61 23840.0 -94500.0 -1.51 -2.2014 -0.9995 1241398 ChemDiv3_004039 C1CCCN(CC1)c2nnc(c3cccs3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H14 compound treatment 18080.0 -96200.0 -1.59 30040.0 -88300.0 -1.41 -2.118 -0.9982 3119548 ChemDiv3_004040 CCc1ccc(N/C=C\2/C(=O)N(C(=O)c3ccccc23)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H15 compound treatment 85920.0 -28300.0 -0.47 73120.0 -45300.0 -0.72 -0.8406 -0.9779 3024030 ChemDiv3_004041 O=C(Oc1ccc(cc1)N(Cc2cccs2)C3=NS(=O)(=O)c4ccccc34)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H16 compound treatment 169200.0 55000.0 0.91 202680.0 84300.0 1.34 1.5917 0.9817 3119549 ChemDiv3_004042 Oc1ccc2oc3CCCCc3c2c1/C=N/N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H17 compound treatment 155680.0 41500.0 0.68 166000.0 47600.0 0.76 1.0205 0.9987 1705908 ChemDiv3_004043 CCOC(=O)CN1C(=O)C2(C(=C(N)Oc3[nH]nc(C)c32)C#N)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H18 compound treatment 29920.0 -84300.0 -1.39 36080.0 -82300.0 -1.31 -1.9117 -0.9996 3024031 ChemDiv3_004044 COc1ccc(CCn2cnc3oc(c(c4ccccc4)c3c2=N)c5ccccc5)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H19 compound treatment 126600.0 12400.0 0.2 137520.0 19100.0 0.3 0.36 0.981 3119550 ChemDiv3_004045 Cc1nc(SC2CCCCN(C(=O)c3ccc(Cl)cc3)C2=O)c4c5CCCCc5sc4n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H20 compound treatment 141760.0 27500.0 0.45 144640.0 26300.0 0.42 0.6172 0.9992 3442340 ChemDiv3_004046 CC(C)CC(Nc1ncnc2sc3CCCc3c12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H21 compound treatment 121080.0 6850.0 0.11 134560.0 16200.0 0.26 0.2623 0.9316 3024084 ChemDiv3_004047 COC(=O)/C=c/1\sc2ncnn2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H22 compound treatment 130320.0 16100.0 0.27 146920.0 28500.0 0.45 0.5094 0.9672 1470170 ChemDiv3_004048 Nc1cc(=O)nc(SCC(=O)NCc2ccccc2)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H23 mock treatment 150960.0 36700.0 0.61 130960.0 12600.0 0.2 0.5704 0.8933 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 H24 mock treatment 62520.0 -51700.0 -0.85 72520.0 -45900.0 -0.73 -1.1205 -0.997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I01 compound treatment 79120.0 -35100.0 -0.58 71480.0 -46900.0 -0.75 -0.9384 -0.9921 3024085 ChemDiv3_004049 Cc1[n+](CC=C)n(C)c2cc(Cl)c(Cl)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I02 compound treatment 112200.0 -2030.0 -0.03 119400.0 1020.0 0.02 -0.0123 -0.3294 3119551 ChemDiv3_004050 COCCn1c(C)cc(/C=C/2\C(=O)NC(=S)N(CC=C)C2=O)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I03 compound treatment 97600.0 -16600.0 -0.27 80480.0 -37900.0 -0.6 -0.6213 -0.9363 1185967 ChemDiv3_004051 CCSc1nnc-2c(OC(Nc3ccccc32)c4cc5OCOc5cc4Cl)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I04 compound treatment 63240.0 -51000.0 -0.84 74240.0 -44100.0 -0.7 -1.0927 -0.996 3119552 ChemDiv3_004052 COc1ccc(Cl)c(NC2=NC(=O)/C(=C\c3cccnc3)/S2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I05 compound treatment 149600.0 35400.0 0.58 146760.0 28400.0 0.45 0.7326 0.992 1528287 ChemDiv3_004053 CSc1nnc-2c(OC(C)N(C(=O)C)c3ccccc32)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I06 compound treatment 46520.0 -67700.0 -1.12 62360.0 -56000.0 -0.89 -1.4218 -0.9938 1788578 ChemDiv3_004054 O=C(CSc1nnc(o1)c2ccccc2)N3c4ccccc4CCc5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I07 compound treatment 133960.0 19700.0 0.33 133160.0 14800.0 0.24 0.3968 0.9873 3024086 ChemDiv3_004055 COC(=O)C1=C(C)NC(=S)NC1c2cc3OCOc3cc2Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I08 compound treatment 11400.0 -103000.0 -1.7 12200.0 -106000.0 -1.69 -2.397 -1.0 3119553 ChemDiv3_004056 FC(F)(F)c1cccc(c1)n2c(=O)oc3ccc(Cl)cc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I09 compound treatment 173760.0 59500.0 0.98 164680.0 46300.0 0.74 1.2166 0.99 3119554 ChemDiv3_004057 CCc1ccc2NC(=O)/C(=C/3\S\C(=N/c4cccc(Cl)c4C)\NC3=O)/c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I10 compound treatment 42600.0 -71600.0 -1.18 57600.0 -60800.0 -0.97 -1.5212 -0.9951 1437793 ChemDiv3_004058 O=C(NCCc1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I11 compound treatment 73160.0 -41100.0 -0.68 55880.0 -62500.0 -1.0 -1.1838 -0.9824 3119555 ChemDiv3_004059 COC(=O)c1cc2c(C)nn(c3ccccc3)c2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I12 compound treatment 34000.0 -80200.0 -1.32 44040.0 -74300.0 -1.18 -1.7744 -0.9985 1679546 ChemDiv3_004060 CCc1ccc(CN2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I13 compound treatment 150480.0 36300.0 0.6 173200.0 54800.0 0.87 1.0409 0.983 3119556 ChemDiv3_004061 CCNS(=O)(=O)c1cc(ccc1C)c2nnc(OC)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I14 compound treatment 123000.0 8770.0 0.14 142280.0 23900.0 0.38 0.3717 0.9122 3024087 ChemDiv3_004062 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I15 compound treatment 133480.0 19300.0 0.32 139080.0 20700.0 0.33 0.4579 0.9998 1737307 ChemDiv3_004063 O=C(N1N=C(CC1c2ccc3nccnc3c2)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I16 compound treatment 127040.0 12800.0 0.21 126920.0 8540.0 0.14 0.2457 0.9772 3024088 ChemDiv3_004064 NC(=N)SCC1CN=C(S1)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I17 compound treatment 173680.0 59500.0 0.98 164200.0 45800.0 0.73 1.2103 0.9894 1449842 ChemDiv3_004065 CNC(=S)NC1CCS(=O)(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I18 compound treatment 143960.0 29700.0 0.49 160160.0 41800.0 0.67 0.8178 0.9887 3119557 ChemDiv3_004066 CCCOc1ccc(cc1OCC)C2C3=C(CCCC3=O)OC4=C2C(=O)CCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I19 compound treatment 161680.0 47500.0 0.78 192800.0 74400.0 1.19 1.3925 0.9797 3024089 ChemDiv3_004067 CCCC(NC1CCS(=O)(=O)C1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I20 compound treatment 112480.0 -1750.0 -0.03 128760.0 10400.0 0.17 0.0965 0.5749 1874878 ChemDiv3_004068 COc1ccc2c(c1)c(=O)oc3c(C)c(OC(C(=O)O)c4ccccc4)ccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I21 compound treatment 122400.0 8170.0 0.13 146920.0 28500.0 0.45 0.417 0.879 1557945 ChemDiv3_004069 CCc1ccccc1NC(=O)CC2CS(=O)(=O)CC2CC(=O)Nc3ccccc3CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I22 compound treatment 126480.0 12300.0 0.2 134920.0 16500.0 0.26 0.3293 0.9914 3024090 ChemDiv3_004070 Cc1cc(OC(=O)c2cccs2)c3c4CCCc4c(=O)oc3c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I23 mock treatment 135800.0 21600.0 0.36 137840.0 19500.0 0.31 0.471 0.9976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 I24 mock treatment 84800.0 -29400.0 -0.49 80280.0 -38100.0 -0.61 -0.773 -0.9939 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J01 compound treatment 5840.0 -108000.0 -1.79 18800.0 -99600.0 -1.59 -2.3875 -0.9982 3024091 ChemDiv3_004071 CC(C)N1C(=O)S/C(=C/c2cc(C)n(c2C)c3ccncc3)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J02 compound treatment 120400.0 6170.0 0.1 141360.0 23000.0 0.37 0.331 0.8707 3119558 ChemDiv3_004072 CC(=O)OC1CCC(OC(=O)C)c2c1[n+]([O-])c(C)c(C)[n+]2[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J03 compound treatment 73120.0 -41100.0 -0.68 66680.0 -51700.0 -0.82 -1.0626 -0.9953 3024092 ChemDiv3_004073 S=c1cc(oc(c1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J04 compound treatment 139880.0 25700.0 0.42 119440.0 1060.0 0.02 0.3113 0.7346 3119559 ChemDiv3_004074 Cc1c(c2ccccc2)[n+]([O-])c(c(C)[n+]1[O-])c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J05 compound treatment 25520.0 -88700.0 -1.46 25680.0 -92700.0 -1.48 -2.0803 -1.0 1128591 ChemDiv3_004075 COc1ccc(CC(=O)Nc2cccc(c2)c3nc4cc5ccccc5cc4[nH]3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J06 compound treatment 147440.0 33200.0 0.55 173720.0 55300.0 0.88 1.0113 0.9738 1255030 ChemDiv3_004076 COc1ccc(cc1OC)C2C(c3cc(OC)c(OC)cc3C2=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J07 compound treatment 130360.0 16100.0 0.27 107520.0 -10900.0 -0.17 0.0658 0.2072 3119560 ChemDiv3_004077 O=C(Nc1cccc(c1)c2nc3ccccc3c(=O)o2)C4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J08 compound treatment 66840.0 -47400.0 -0.78 64840.0 -53500.0 -0.85 -1.1566 -0.9991 3024093 ChemDiv3_004078 CCOC(=O)c1nn(c(C(=O)OCC)c1NC(=O)C2CCCCC2)c3ccc(OC)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J09 compound treatment 179880.0 65700.0 1.08 153040.0 34700.0 0.55 1.1569 0.9511 1215988 ChemDiv3_004079 OC(=O)c1c2CC(CCc2nc3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J10 compound treatment 18880.0 -95400.0 -1.57 16560.0 -102000.0 -1.62 -2.2606 -0.9999 3119561 ChemDiv3_004080 CC1CN=C(S1)N(C(=O)Nc2ccccc2)c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J11 compound treatment 165880.0 51700.0 0.85 166480.0 48100.0 0.77 1.1449 0.9986 1549011 ChemDiv3_004081 Cc1ccc(cc1)c2nn3c(=O)c4ccccc4nc3c5ccccc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J12 compound treatment 91720.0 -22500.0 -0.37 115280.0 -3110.0 -0.05 -0.2977 -0.7943 1317257 ChemDiv3_004082 CCc1ccc(cc1)n2c(N)c(C(=O)OC)c3nc4ccccc4nc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J13 compound treatment 139600.0 25400.0 0.42 162320.0 43900.0 0.7 0.7913 0.9698 3024094 ChemDiv3_004083 O=C(CSc1ncnc2sc(cc12)c3ccccc3)c4ccc5OCCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J14 compound treatment 18960.0 -95300.0 -1.57 20120.0 -98300.0 -1.57 -2.2195 -1.0 3119562 ChemDiv3_004084 FC(F)(F)c1cccc(N/C=C\2/C(=O)N(C(=O)c3ccccc23)c4ccccc4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J15 compound treatment 120240.0 6010.0 0.1 111960.0 -6430.0 -0.1 -0.0023 -0.0159 1305983 ChemDiv3_004085 CCCN1CC=C2C(C1)C3(C(=O)Nc4ccccc43)C(C#N)(C#N)C(=C2C#N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J16 compound treatment 158480.0 44300.0 0.73 152480.0 34100.0 0.54 0.9008 0.9894 1458619 ChemDiv3_004086 CC(C)(C)c1nc2scc(c3ccccc3)c2c(=O)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J17 compound treatment 146400.0 32200.0 0.53 136280.0 17900.0 0.29 0.5772 0.9575 1274153 ChemDiv3_004087 CCOC(=O)C1=C(N)Oc2c(c(=O)oc3ccccc23)C41C(=O)N(CC(=O)OC)c5ccccc54 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J18 compound treatment 27520.0 -86700.0 -1.43 58800.0 -59600.0 -0.95 -1.6836 -0.9801 1393431 ChemDiv3_004088 CCn1c(=O)c2c(-c3ccccc3CC42CCCCC4)n5c(SCC(=O)N)nnc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J19 compound treatment 9880.0 -104000.0 -1.72 11120.0 -107000.0 -1.71 -2.4269 -1.0 3119696 ChemDiv3_004089 CCN(CC)C(=O)O[n+]1cccc(CC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J20 compound treatment 17400.0 -96800.0 -1.6 41200.0 -77200.0 -1.23 -2.0001 -0.9916 3119697 ChemDiv3_004090 C=CCN1C(=C(OC(=O)c2ccccc2)c3ccccc3S1(=O)=O)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J21 compound treatment 119320.0 5090.0 0.08 151840.0 33500.0 0.53 0.4365 0.8086 1423420 ChemDiv3_004091 Cc1cc(C)n(n1)c2nnc(C)n2NC(=S)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J22 compound treatment 92960.0 -21300.0 -0.35 114280.0 -4110.0 -0.07 -0.2945 -0.8247 3119698 ChemDiv3_004092 COC(=O)/C=C/1\N(C(=NC1=O)Nc2nc(C)cc(C)n2)c3cccc(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J23 mock treatment 136400.0 22200.0 0.37 154960.0 36600.0 0.58 0.671 0.9748 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 J24 mock treatment 96760.0 -17500.0 -0.29 111960.0 -6430.0 -0.1 -0.2763 -0.903 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K01 compound treatment 64080.0 -50200.0 -0.83 60480.0 -57900.0 -0.92 -1.238 -0.9985 3023297 ChemDiv3_004093 Oc1cc(C2C(=O)c3ccccc3C2=O)c4ccc5ccccc5c4n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K02 compound treatment 109840.0 -4390.0 -0.07 94360.0 -24000.0 -0.38 -0.322 -0.8263 3119699 ChemDiv3_004094 COCCn1c(C)cc(C=C2C(=O)N(C)C(=S)N(C)C2=O)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K03 compound treatment 111760.0 -2470.0 -0.04 108520.0 -9870.0 -0.16 -0.14 -0.862 1169810 ChemDiv3_004095 CSc1nnc-2c(OC(Nc3ccccc32)c4ccccc4)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K04 compound treatment 109560.0 -4670.0 -0.08 113160.0 -5230.0 -0.08 -0.1134 -0.9993 3119700 ChemDiv3_004096 OC(=O)c1ccc(cc1)c2ccc(/C=C\3/SC(=NC3=O)Nc4cccc(c4)C(=O)O)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K05 compound treatment 60880.0 -53400.0 -0.88 62320.0 -56100.0 -0.89 -1.2546 -1.0 3119701 ChemDiv3_004097 CC/1=NN(C(=O)\C1=C/Nc2cc(C)ccn2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K06 compound treatment 111400.0 -2830.0 -0.05 117240.0 -1150.0 -0.02 -0.0459 -0.9159 1871177 ChemDiv3_004098 COc1ccc(Nc2nc(N)nc(CN3CCCCC3)n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K07 compound treatment 157280.0 43100.0 0.71 141480.0 23100.0 0.37 0.7628 0.9531 3119702 ChemDiv3_004099 CN/1C(=N)NC(=O)\C1=C\c2ccc(C)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K08 compound treatment 105760.0 -8470.0 -0.14 86320.0 -32100.0 -0.51 -0.4602 -0.8686 3023298 ChemDiv3_004100 COc1ccc(C=C2C(=O)OC3(CCCCC3)OC2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K09 compound treatment 94840.0 -19400.0 -0.32 107560.0 -10800.0 -0.17 -0.3483 -0.958 3119703 ChemDiv3_004101 CCOc1cc(/C=C/2\C(=O)Nc3ccc(Br)cc23)ccc1OCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K10 compound treatment 43920.0 -70300.0 -1.16 49080.0 -69300.0 -1.1 -1.6018 -0.9997 1400389 ChemDiv3_004102 CCOC(=O)C1CCN(CC1)C(=O)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K11 compound treatment 153000.0 38800.0 0.64 139480.0 21100.0 0.34 0.6903 0.9548 1679244 ChemDiv3_004103 Cc1ccc(Nc2nc(C)cc(C)c2C(=O)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K12 compound treatment 153800.0 39600.0 0.65 162840.0 44500.0 0.71 0.9629 0.9992 1721188 ChemDiv3_004104 CCCS(=O)(=O)N1CCN(CC1)C2CCN(CC2)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K13 compound treatment 19280.0 -95000.0 -1.57 29400.0 -89000.0 -1.42 -2.1112 -0.9988 1612458 ChemDiv3_004105 CCn1c2ccccc2c3cc(NS(=O)(=O)c4ccccc4)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K14 compound treatment 137680.0 23500.0 0.39 142600.0 24200.0 0.39 0.5466 1.0 1300482 ChemDiv3_004106 CN1C(=C(N2CCOCC2)c3ccccc3S1(=O)=O)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K15 compound treatment 140280.0 26100.0 0.43 154680.0 36300.0 0.58 0.7131 0.9893 3023329 ChemDiv3_004107 COc1ccc(cc1)C2=NN(C(C2)c3ccccc3OC)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K16 compound treatment 128680.0 14500.0 0.24 143960.0 25600.0 0.41 0.4569 0.9674 3119704 ChemDiv3_004108 NC1(N)OC(CN2C(=O)c3ccccc3C2=O)CS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K17 compound treatment 149280.0 35100.0 0.58 147480.0 29100.0 0.46 0.737 0.994 1697884 ChemDiv3_004109 CCOC(=O)NC1CS(=O)(=O)C=C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K18 compound treatment 125680.0 11500.0 0.19 141040.0 22700.0 0.36 0.389 0.9544 3119705 ChemDiv3_004110 CCN1C2=C(C(C3=C1CC(C)(C)CC3=O)c4ccc(OC)cc4)C(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K19 compound treatment 163440.0 49200.0 0.81 149600.0 31200.0 0.5 0.9262 0.9723 1179086 ChemDiv3_004111 O=S1(=O)CCC(C1)NC(=S)N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K20 compound treatment 155400.0 41200.0 0.68 161000.0 42600.0 0.68 0.9608 1.0 3119706 ChemDiv3_004112 CCCN1Cc2cccc(C(=O)N)c2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K21 compound treatment 104160.0 -10100.0 -0.17 110440.0 -7950.0 -0.13 -0.2071 -0.991 1541504 ChemDiv3_004113 CC(C)NC(=S)SC1CS(=O)(=O)C=C1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K22 compound treatment 103960.0 -10300.0 -0.17 108520.0 -9870.0 -0.16 -0.2311 -0.9993 1280043 ChemDiv3_004114 Cc1cc(=O)oc2cc(OCc3cccc(F)c3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K23 mock treatment 123320.0 9090.0 0.15 116280.0 -2110.0 -0.03 0.0824 0.5358 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 K24 mock treatment 73600.0 -40600.0 -0.67 84640.0 -33700.0 -0.54 -0.8546 -0.994 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L01 compound treatment 31240.0 -83000.0 -1.37 36800.0 -81600.0 -1.3 -1.8882 -0.9997 3119707 ChemDiv3_004115 COCCN1C(=O)N(C(=O)/C(=C\c2cn(CC(=O)OC)c3ccccc23)/C1=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L02 compound treatment 132040.0 17800.0 0.29 140400.0 22000.0 0.35 0.456 0.9961 3023337 ChemDiv3_004116 CC1=[N+]([O-])C(C)(C)C(=[N+]1[O-])c2ccc(C)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L03 compound treatment 7640.0 -107000.0 -1.76 8040.0 -110000.0 -1.76 -2.4878 -1.0 3119708 ChemDiv3_004117 CCOc1ccc(cc1c2nc(=O)c3n(C)nc(c3[nH]2)C(C)(C)C)S(=O)(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L04 compound treatment 113160.0 -1070.0 -0.02 131040.0 12700.0 0.2 0.1301 0.6427 3023341 ChemDiv3_004118 [O-][n+]1cc(c2ccccc2)[n+]([O-])c3CCCCc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L05 compound treatment 133480.0 19300.0 0.32 117600.0 -785.0 -0.01 0.2158 0.6787 3023342 ChemDiv3_004119 CC(C)C(=O)Nc1cccc(c1)c2nc3ccccc3c(=O)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L06 compound treatment 23640.0 -90600.0 -1.5 21680.0 -96700.0 -1.54 -2.1473 -0.9999 3119709 ChemDiv3_004120 CCc1ccc(OCCCn2cc(/C=C\3/C(=N)N4C=CSC4=NC3=O)c5ccccc25)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L07 compound treatment 107240.0 -6990.0 -0.12 97680.0 -20700.0 -0.33 -0.3149 -0.9009 3023344 ChemDiv3_004121 CCSc1ncnc2c3cc4COC(C)(C)Cc4nc3sc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L08 compound treatment 140440.0 26200.0 0.43 123800.0 5420.0 0.09 0.367 0.8318 1713113 ChemDiv3_004122 O=S1(=O)C=C(SCCN2CCOCC2)c3ccccc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L09 compound treatment 62760.0 -51500.0 -0.85 79920.0 -38500.0 -0.61 -1.0343 -0.9872 3023346 ChemDiv3_004123 CN(C)c1oc(nc1C#N)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L10 compound treatment 63880.0 -50400.0 -0.83 74560.0 -43800.0 -0.7 -1.0816 -0.9963 3119710 ChemDiv3_004124 CCC1(COC(NC(=O)c2ccc(Cl)cc2Cl)(C(F)(F)F)C(F)(F)F)COC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L11 compound treatment 13280.0 -101000.0 -1.67 41880.0 -76500.0 -1.22 -2.0406 -0.9882 1380020 ChemDiv3_004125 CCC1CCc2c(C1)sc3ncnc(N4CCOCC4)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L12 compound treatment 66240.0 -48000.0 -0.79 70000.0 -48400.0 -0.77 -1.1055 -0.9999 1709855 ChemDiv3_004126 CCOc1ccc(cc1)S(=O)(=O)Nc2nc3ccccc3nc2Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L13 compound treatment 134120.0 19900.0 0.33 165200.0 46800.0 0.75 0.7598 0.932 1688543 ChemDiv3_004127 Cc1cc(C)c(C)c(c1C)S(=O)(=O)N2CCN(CC2)c3ncnc4sc5CCCCc5c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L14 compound treatment 111920.0 -2310.0 -0.04 123280.0 4900.0 0.08 0.0282 0.3248 1554741 ChemDiv3_004128 COc1ccc2n(CCc3ccc(OC)c(OC)c3)c(C)c(C(=O)O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L15 compound treatment 114320.0 90.0 0.0 122600.0 4220.0 0.07 0.0486 0.7226 1579821 ChemDiv3_004129 COC(=O)CC1=C(C(=O)OC)C2(C(=O)Nc3ccccc32)C(=C(N)O1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L16 compound treatment 9800.0 -104000.0 -1.72 11000.0 -107000.0 -1.71 -2.4292 -1.0 3119711 ChemDiv3_004130 O/N=C/c1c(O)c(Br)cc2oc3CCCCc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L17 compound treatment 105360.0 -8870.0 -0.15 142160.0 23800.0 0.38 0.1644 0.4047 1421908 ChemDiv3_004131 O=c1n(CN2CCCCC2)nnc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L18 compound treatment 65360.0 -48900.0 -0.81 115360.0 -3030.0 -0.05 -0.6045 -0.748 1535030 ChemDiv3_004132 COc1ccc(cc1)C(=O)n2nc3CC(C)(C)OCc3c2c4ccc(OC)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L19 compound treatment 125480.0 11300.0 0.19 131440.0 13100.0 0.21 0.2784 0.9984 3119712 ChemDiv3_004133 Cc1ccc(cc1)S(=O)(=O)N/2C(=O)C(C)(C)S\C2=N/CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L20 compound treatment 155280.0 41100.0 0.68 164560.0 46200.0 0.74 0.9996 0.9991 1346941 ChemDiv3_004134 CN1CCN(Cc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L21 compound treatment 94960.0 -19300.0 -0.32 98080.0 -20300.0 -0.32 -0.4538 -1.0 3119713 ChemDiv3_004135 Cc1nnc(SCc2cccc(c2)C(=O)c3ccccc3)nc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L22 compound treatment 90920.0 -23300.0 -0.38 121680.0 3300.0 0.05 -0.2349 -0.605 3119714 ChemDiv3_004136 CC1CCN(CC1)/C(=N\S(=O)(=O)c2ccc(Br)cc2)/Nc3nc(C)cc(C)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L23 mock treatment 128600.0 14400.0 0.24 118640.0 255.0 0.0 0.1706 0.7191 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 L24 mock treatment 70480.0 -43800.0 -0.72 99880.0 -18500.0 -0.29 -0.7192 -0.922 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M01 compound treatment 4360.0 -110000.0 -1.81 4440.0 -114000.0 -1.82 -2.5666 -1.0 3119869 ChemDiv3_004137 CCc1cc(C)cc(OCCn2cc(C=C3C(=O)NC(=O)NC3=O)c4ccccc24)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M02 compound treatment 86520.0 -27700.0 -0.46 94520.0 -23900.0 -0.38 -0.5924 -0.9958 3023448 ChemDiv3_004138 CN1C(=O)C(=Cc2cn(CC=C)c3ccccc23)C(=O)N(C)C1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M03 compound treatment 54880.0 -59400.0 -0.98 69520.0 -48900.0 -0.78 -1.2435 -0.9935 3023450 ChemDiv3_004139 CCc1cccc2c1NC(=O)C32OCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M04 compound treatment 99400.0 -14800.0 -0.24 77160.0 -41200.0 -0.66 -0.6377 -0.9095 1912757 ChemDiv3_004140 Cc1cc2/C(=C/c3ccco3)/OC(=O)c2c(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M05 compound treatment 56280.0 -58000.0 -0.96 62800.0 -55600.0 -0.89 -1.3029 -0.9993 3119870 ChemDiv3_004141 CCSC1=N/C(=C\c2ccc(cc2)C(=O)O)/C(=O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M06 compound treatment 97720.0 -16500.0 -0.27 108000.0 -10400.0 -0.17 -0.3098 -0.9714 3023453 ChemDiv3_004142 O=C(COc1ccccc1)N2CCN=C2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M07 compound treatment 91720.0 -22500.0 -0.37 99480.0 -18900.0 -0.3 -0.4758 -0.9946 1181595 ChemDiv3_004143 CCC(=O)N1C(Oc2nc(SC)nnc2-c3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M08 compound treatment 69840.0 -44400.0 -0.73 84520.0 -33900.0 -0.54 -0.8998 -0.9887 1618375 ChemDiv3_004144 S=C1NC(C2=C(N1)c3ccccc3CC2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M09 compound treatment 35520.0 -78700.0 -1.3 45720.0 -72700.0 -1.16 -1.7377 -0.9984 3023457 ChemDiv3_004145 CCCCN1C(=O)/C(=C/2\S/C(=N\c3ccc(Cl)cc3)/N(C)C2=O)/c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M10 compound treatment 21920.0 -92300.0 -1.52 22720.0 -95700.0 -1.52 -2.1556 -1.0 3119871 ChemDiv3_004146 O=C(NCCCc1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M11 compound treatment 51120.0 -63100.0 -1.04 55360.0 -63000.0 -1.0 -1.4469 -0.9998 1406185 ChemDiv3_004147 Cc1cc(C)c2c(N=NN3CCCCCC3)n[nH]c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M12 compound treatment 117720.0 3490.0 0.06 108480.0 -9910.0 -0.16 -0.0709 -0.4219 3119872 ChemDiv3_004148 Cc1cc(Br)ccc1NCc2ccc3OCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M13 compound treatment 162760.0 48500.0 0.8 175960.0 57600.0 0.92 1.2153 0.9977 1438334 ChemDiv3_004149 Brc1ccc2oc(=O)c(cc2c1)C(=O)N3CCCc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M14 compound treatment 91440.0 -22800.0 -0.38 115720.0 -2670.0 -0.04 -0.296 -0.782 3023462 ChemDiv3_004150 CN1C(=C(Nc2ccccc2C)c3ccccc3S1(=O)=O)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M15 compound treatment 96640.0 -17600.0 -0.29 123280.0 4900.0 0.08 -0.1501 -0.4994 1567678 ChemDiv3_004151 COc1ccc(cc1)C2=NN(C(C2)c3ccc(C)cc3)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M16 compound treatment 109400.0 -4830.0 -0.08 132520.0 14100.0 0.23 0.1029 0.4307 3023506 ChemDiv3_004152 OC(=O)CP(=S)(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M17 compound treatment 23880.0 -90400.0 -1.49 20320.0 -98100.0 -1.56 -2.1598 -0.9997 1339249 ChemDiv3_004153 CCSC(=S)NC1CCS(=O)(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M18 compound treatment 97000.0 -17200.0 -0.28 92160.0 -26200.0 -0.42 -0.4967 -0.9824 3119873 ChemDiv3_004154 CCN1C2=C(C(C3=C1CCCC3=O)c4cccc(O)c4)C(=O)CCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M19 compound treatment 135160.0 20900.0 0.35 151280.0 32900.0 0.52 0.615 0.9795 1468946 ChemDiv3_004155 CN(C1CCS(=O)(=O)C1)C(=S)SC2CS(=O)(=O)C=C2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M20 compound treatment 116680.0 2450.0 0.04 152040.0 33700.0 0.54 0.4079 0.7583 1541732 ChemDiv3_004156 COC(=O)c1ccc(COc2ccc3c(cc(=O)oc3c2C)c4ccccc4)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M21 compound treatment 133320.0 19100.0 0.32 140360.0 22000.0 0.35 0.4705 0.9986 1306134 ChemDiv3_004157 CN(C1CCCCC1)S(=O)(=O)C2CCS(=O)(=O)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M22 compound treatment 98720.0 -15500.0 -0.26 118880.0 495.0 0.01 -0.1755 -0.685 3119874 ChemDiv3_004158 CC1CN(CC(C)O1)C2=NC(=O)/C(=C/c3ccccc3)/S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M23 mock treatment 126800.0 12600.0 0.21 135000.0 16600.0 0.26 0.334 0.9927 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 M24 mock treatment 99040.0 -15200.0 -0.25 122560.0 4180.0 0.07 -0.1303 -0.5021 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N01 compound treatment 19240.0 -95000.0 -1.57 27440.0 -90900.0 -1.45 -2.1337 -0.9992 3023511 ChemDiv3_004159 O=C1S/C(=C\c2ccc(o2)N3CCOCC3)/C(=O)N1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N02 compound treatment 106240.0 -7990.0 -0.13 80920.0 -37500.0 -0.6 -0.5155 -0.843 3119875 ChemDiv3_004160 CC1=[N+]([O-])C(C)(C)C(=[N+]1[O-])c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N03 compound treatment 13400.0 -101000.0 -1.66 21160.0 -97200.0 -1.55 -2.2727 -0.9994 3023512 ChemDiv3_004161 C1CCC2=C(C1)SC3=C(CCCC3)C2c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N04 compound treatment 27120.0 -87100.0 -1.44 20880.0 -97500.0 -1.55 -2.1157 -0.9992 1863423 ChemDiv3_004162 CSc1cccc(NC(=O)c2cc3c(ccc4ccccc34)o2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N05 compound treatment 17200.0 -97000.0 -1.6 15920.0 -102000.0 -1.63 -2.2874 -1.0 3023514 ChemDiv3_004163 O=C(ON1C(=O)c2ccccc2C1=O)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N06 compound treatment 81960.0 -32300.0 -0.53 88400.0 -30000.0 -0.48 -0.7146 -0.9985 1713635 ChemDiv3_004164 COC(=O)C1=C(C)Nc2c(C1c3cccc(OCc4ccccc4)c3)c(=O)n(C)c(=O)n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N07 compound treatment 99760.0 -14500.0 -0.24 115640.0 -2750.0 -0.04 -0.1998 -0.8229 3023519 ChemDiv3_004165 CCCCS(=O)(=O)N=C1NCN(CCO)CN1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N08 compound treatment 69640.0 -44600.0 -0.74 69280.0 -49100.0 -0.78 -1.0739 -0.9995 3119876 ChemDiv3_004166 CC(C)(C)C1CCc2c(C1)sc3nc(oc(=O)c23)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N09 compound treatment 109480.0 -4750.0 -0.08 94960.0 -23400.0 -0.37 -0.3194 -0.8373 3119877 ChemDiv3_004167 CCOC(=O)c1c(NC(=O)CC2S/C(=N\CC)/N(CC)C2=O)sc3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N10 compound treatment 96680.0 -17600.0 -0.29 106720.0 -11700.0 -0.19 -0.3363 -0.977 3023583 ChemDiv3_004168 COc1ccc(CNC(=N)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N11 compound treatment 7280.0 -107000.0 -1.77 7920.0 -110000.0 -1.76 -2.4933 -1.0 1550858 ChemDiv3_004169 CC1CCN(CC1)c2nnc(c3cccs3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N12 compound treatment 120480.0 6250.0 0.1 156480.0 38100.0 0.61 0.5023 0.8156 1484112 ChemDiv3_004170 O=S(=O)(Nc1nc2ccccc2nc1NCCC3=CCCCC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N13 compound treatment 104840.0 -9390.0 -0.16 146160.0 27800.0 0.44 0.2034 0.4337 1570344 ChemDiv3_004171 CCc1nc(n2nnc3cc(C)c(C)cc23)c4c5CCCCc5sc4n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N14 compound treatment 61000.0 -53200.0 -0.88 54680.0 -63700.0 -1.02 -1.3393 -0.9974 1352096 ChemDiv3_004172 CCOC(=O)c1c(C)n(C(C)C)c2ccc(OC(=O)c3ccccc3)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N15 compound treatment 87400.0 -26800.0 -0.44 111640.0 -6750.0 -0.11 -0.3892 -0.8539 1652261 ChemDiv3_004173 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C32C(=O)N(CO)c4ccccc43)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N16 compound treatment 7320.0 -107000.0 -1.76 8440.0 -110000.0 -1.75 -2.487 -1.0 3023589 ChemDiv3_004174 CC(C)(C)c1cc2oc3CCCCc3c2c(/C=N/Cc4ccncc4)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N17 compound treatment 56000.0 -58200.0 -0.96 72000.0 -46400.0 -0.74 -1.2025 -0.9916 1176412 ChemDiv3_004175 Cc1onc(c1C(=O)NC(=S)NCc2ccco2)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N18 compound treatment 80960.0 -33300.0 -0.55 95080.0 -23300.0 -0.37 -0.651 -0.9819 1286690 ChemDiv3_004176 CC1(C)CC(CC(=O)N2CCOCC2)(CCO1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N19 compound treatment 7760.0 -106000.0 -1.76 8920.0 -109000.0 -1.74 -2.4765 -1.0 1350975 ChemDiv3_004177 Cc1nn(C(=O)c2cccnc2)c(c1Sc3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N20 compound treatment 120440.0 6210.0 0.1 141640.0 23300.0 0.37 0.3346 0.87 3119878 ChemDiv3_004178 CCCN(CCC)CN1CC(Cn2c3ccccc3c4ccccc24)OC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N21 compound treatment 149400.0 35200.0 0.58 155360.0 37000.0 0.59 0.8272 1.0 1867988 ChemDiv3_004179 CC1CC(c2ccccc2)c3cc(C)ccc3N1S(=O)(=O)c4cccc(Cl)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N22 compound treatment 109800.0 -4430.0 -0.07 112040.0 -6350.0 -0.1 -0.1232 -0.9873 3119879 ChemDiv3_004180 Clc1ccc(cc1)C(=O)NC(=N)NCc2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N23 mock treatment 112440.0 -1790.0 -0.03 114480.0 -3910.0 -0.06 -0.0649 -0.942 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 N24 mock treatment 95160.0 -19100.0 -0.31 141200.0 22800.0 0.36 0.0345 0.0718 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O01 compound treatment 79480.0 -34800.0 -0.57 75600.0 -42800.0 -0.68 -0.8878 -0.9963 3023594 ChemDiv3_004181 CSc1nnc(c(O)n1)c2ccccc2N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O02 compound treatment 80880.0 -33400.0 -0.55 66840.0 -51500.0 -0.82 -0.9702 -0.981 3119880 ChemDiv3_004182 NC(=O)COc1ccc(C=C2C(=O)c3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O03 compound treatment 89480.0 -24800.0 -0.41 94400.0 -24000.0 -0.38 -0.5592 -0.9994 3023659 ChemDiv3_004183 CCc1ccc2NC(=O)/C(=C/3\NC(=S)NC3=O)/c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O04 compound treatment 133320.0 19100.0 0.32 136800.0 18400.0 0.29 0.4304 0.9994 1537162 ChemDiv3_004184 COCc1cc(C)nc2sc(C(=O)N)c(N)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O05 compound treatment 52360.0 -61900.0 -1.02 45640.0 -72700.0 -1.16 -1.542 -0.998 3023662 ChemDiv3_004185 COc1cccc(/C=C/2\N=C(SC)SC2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O06 compound treatment 91520.0 -22700.0 -0.37 87240.0 -31100.0 -0.5 -0.6161 -0.9904 3119881 ChemDiv3_004186 COc1cc(OC)cc(c1)C(=O)N2CCN=C2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O07 compound treatment 60560.0 -53700.0 -0.89 64720.0 -53700.0 -0.86 -1.2313 -0.9998 3023663 ChemDiv3_004187 CCN(CC)c1ccc(/C=C/2\N(C)C(=N)NC2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O08 compound treatment 5640.0 -109000.0 -1.79 5720.0 -113000.0 -1.8 -2.5373 -1.0 3119882 ChemDiv3_004188 CC(O)CN1C(=O)/C(=C/c2ccc(o2)c3ccc(Br)cc3)/C(=C(C#N)C1=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O09 compound treatment 69560.0 -44700.0 -0.74 55560.0 -62800.0 -1.0 -1.2295 -0.9887 3023665 ChemDiv3_004189 CSC1=N/C(=C\c2ccc(Br)cc2)/C(=O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O10 compound treatment 103760.0 -10500.0 -0.17 101760.0 -16600.0 -0.26 -0.3096 -0.9786 1520777 ChemDiv3_004190 CN1C(=O)C(C2CC1(C)Oc3ccccc23)C(=O)NC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O11 compound treatment 28000.0 -86200.0 -1.42 25440.0 -92900.0 -1.48 -2.054 -0.9998 1527053 ChemDiv3_004191 O=C(CN1CC(=O)Oc2ccccc12)OCC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O12 compound treatment 6880.0 -107000.0 -1.77 7720.0 -111000.0 -1.76 -2.5002 -1.0 3120033 ChemDiv3_004192 CCn1c2ccccc2c3cc(CNCCc4ccc(Cl)cc4)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O13 compound treatment 135120.0 20900.0 0.34 133560.0 15200.0 0.24 0.4149 0.9849 1472912 ChemDiv3_004193 O=C(NC1(CCCCC1)C#N)c2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O14 compound treatment 78960.0 -35300.0 -0.58 109920.0 -8470.0 -0.13 -0.5071 -0.8485 3120034 ChemDiv3_004194 CCCN(CCC)C1=C(N(C)S(=O)(=O)c2ccccc12)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O15 compound treatment 114000.0 -230.0 0.0 120840.0 2460.0 0.04 0.025 0.6355 3120035 ChemDiv3_004195 CS(=O)(=O)N1N=C(CC1c2cc3ccccc3nc2Cl)c4ccc(Br)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O16 compound treatment 65160.0 -49100.0 -0.81 49680.0 -68700.0 -1.1 -1.3471 -0.989 1484690 ChemDiv3_004196 OC(=O)CCNc1ncnc2sc3CCCCc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O17 compound treatment 107760.0 -6470.0 -0.11 116000.0 -2390.0 -0.04 -0.1024 -0.9033 3120036 ChemDiv3_004197 C=CCN1[C@H]2CS(=O)(=O)C[C@H]2NC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O18 compound treatment 71600.0 -42600.0 -0.7 75880.0 -42500.0 -0.68 -0.9766 -0.9998 1564957 ChemDiv3_004198 CCOc1ccc(cc1)C2C3=C(CCCC3=O)NC4=C2C(=O)CCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O19 compound treatment 99880.0 -14400.0 -0.24 97120.0 -21300.0 -0.34 -0.4072 -0.9847 3023723 ChemDiv3_004199 CC1=CS(=O)(=O)CC1Sc2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O20 compound treatment 99240.0 -15000.0 -0.25 79880.0 -38500.0 -0.61 -0.6089 -0.9202 1479636 ChemDiv3_004200 Cc1oc(cc1COc2ccc3c4CCCCc4c(=O)oc3c2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O21 compound treatment 76520.0 -37700.0 -0.62 86400.0 -32000.0 -0.51 -0.8006 -0.9951 3023725 ChemDiv3_004201 Cc1nc2sc3CCCCc3c2c4nnc(SCC(=O)c5ccccc5)n14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O22 compound treatment 38840.0 -75400.0 -1.24 34440.0 -83900.0 -1.34 -1.8261 -0.9993 3120037 ChemDiv3_004202 CC1CCC2(CC1)NN(C(=S)N2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O23 mock treatment 124400.0 10200.0 0.17 118240.0 -145.0 0.0 0.1171 0.6973 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 O24 mock treatment 100560.0 -13700.0 -0.23 122480.0 4100.0 0.07 -0.1134 -0.4828 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P01 compound treatment 85000.0 -29200.0 -0.48 80840.0 -37500.0 -0.6 -0.7643 -0.9943 3120038 ChemDiv3_004203 COCCN1C(=O)N(C(=O)/C(=C\c2cc(C)n(c2C)c3ccncc3)/C1=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P02 compound treatment 102400.0 -11800.0 -0.2 84760.0 -33600.0 -0.54 -0.517 -0.9065 3023728 ChemDiv3_004204 CCc1c(C)[n+]([O-])c2CCCCCc2[n+]1[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P03 compound treatment 43520.0 -70700.0 -1.17 38480.0 -79900.0 -1.27 -1.7259 -0.9991 3023729 ChemDiv3_004205 COC(=O)c1ccc(OCC(O)Cn2c(C)[n+](C)c3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P04 compound treatment 87880.0 -26400.0 -0.43 99760.0 -18600.0 -0.3 -0.5175 -0.9827 3120039 ChemDiv3_004206 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCN(CC3)C(=O)c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P05 compound treatment 28520.0 -85700.0 -1.41 15200.0 -103000.0 -1.64 -2.1634 -0.9972 3023733 ChemDiv3_004207 O=C(ON1C(=O)c2ccccc2C1=O)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P06 compound treatment 94720.0 -19500.0 -0.32 86800.0 -31600.0 -0.5 -0.5837 -0.9767 1192417 ChemDiv3_004208 COc1cc(cc(OC)c1OC)C2C3=C(CCCC3=O)Nc4[nH]c(=O)[nH]c(=O)c24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P07 compound treatment 94720.0 -19500.0 -0.32 85040.0 -33300.0 -0.53 -0.6035 -0.9712 3120040 ChemDiv3_004209 CC(=O)Nc1ccc(cc1)S(=O)(=O)N=C2NCN(CCOC(=O)c3ccccc3)CN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P08 compound treatment 56320.0 -57900.0 -0.96 54000.0 -64400.0 -1.03 -1.4016 -0.9994 3023735 ChemDiv3_004210 COC(=O)c1c(C)nn(c1NC(=O)C(C)Oc2ccc(Cl)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P09 compound treatment 20960.0 -93300.0 -1.54 19840.0 -98500.0 -1.57 -2.1993 -1.0 1521251 ChemDiv3_004211 Cc1cc2nnn(c3nc(C)nc4sc5CCCCc5c34)c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P10 compound treatment 91080.0 -23200.0 -0.38 73080.0 -45300.0 -0.72 -0.7808 -0.9557 3023737 ChemDiv3_004212 CSc1nc(C)cc(NC(=O)N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P11 compound treatment 69200.0 -45000.0 -0.74 72000.0 -46400.0 -0.74 -1.0484 -1.0 1165643 ChemDiv3_004213 CC(C)(C)c1ccc(cc1)c2cc3ccccn3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P12 compound treatment 53880.0 -60400.0 -1.0 68360.0 -50000.0 -0.8 -1.2682 -0.9939 1379043 ChemDiv3_004214 Fc1ccccc1Nc2nc3ccccc3nc2NS(=O)(=O)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P13 compound treatment 17320.0 -96900.0 -1.6 13480.0 -105000.0 -1.67 -2.3135 -0.9998 3120041 ChemDiv3_004215 Cc1cc(C(=O)CSc2ncnc3sc4CCCCc4c23)c(C)n1Cc5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P14 compound treatment 8520.0 -106000.0 -1.74 7320.0 -111000.0 -1.77 -2.4856 -1.0 3024070 ChemDiv3_004216 CN1C(=O)/C(=C/Nc2cccc(Cl)c2)/c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P15 compound treatment 81760.0 -32500.0 -0.54 91560.0 -26800.0 -0.43 -0.6813 -0.9937 1257595 ChemDiv3_004217 OC(=O)CSc1nnc-2c(OC3(CCCC3)Nc4ccccc42)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P16 compound treatment 39680.0 -74600.0 -1.23 42000.0 -76400.0 -1.22 -1.7311 -1.0 3024074 ChemDiv3_004218 CN1C(=O)/C(=C\Nc2cccc(CO)c2)/c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P17 compound treatment 117440.0 3210.0 0.05 123080.0 4700.0 0.07 0.0904 0.9857 3120042 ChemDiv3_004219 Cc1ccc(Oc2ncnc3sccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P18 compound treatment 93840.0 -20400.0 -0.34 86000.0 -32400.0 -0.52 -0.603 -0.9785 3024079 ChemDiv3_004220 CC1=N/C(=C/c2cc3ccccc3nc2Sc4ccc(C)cc4)/C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P19 compound treatment 78400.0 -35800.0 -0.59 71840.0 -46500.0 -0.74 -0.9428 -0.9937 1244804 ChemDiv3_004221 COc1ccc(cc1OC)C(=O)Nn2c(C)nnc2n3nc(C)cc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P20 compound treatment 73000.0 -41200.0 -0.68 72600.0 -45800.0 -0.73 -0.9973 -0.9994 3120043 ChemDiv3_004222 CC(C)CN(CC(C)C)CN1CC(COc2ccccc2C)OC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P21 compound treatment 68880.0 -45400.0 -0.75 63160.0 -55200.0 -0.88 -1.1517 -0.9968 3023284 ChemDiv3_004223 COC(=O)C1=CN(C=C(C1c2cccc(OC)c2)C(=O)OC)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P22 compound treatment 51000.0 -63200.0 -1.04 48600.0 -69800.0 -1.11 -1.5245 -0.9995 1820755 ChemDiv3_004224 O=C(CSc1nnnn1c2ccccc2)N3c4ccccc4CCc5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P23 mock treatment 111400.0 -2830.0 -0.05 107120.0 -11300.0 -0.18 -0.16 -0.8624 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2012 P24 mock treatment 105440.0 -8790.0 -0.15 115880.0 -2510.0 -0.04 -0.1308 -0.8694 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A01 compound treatment 31120.0 -39700.0 -0.66 98840.0 -23200.0 -0.37 -0.7251 -0.9631 3027680 ChemDiv3_007041 FC(F)(F)c1cc(nc(SCCCC(=O)NC2CCCC2)n1)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A02 compound treatment 4240.0 -66600.0 -1.1 4600.0 -117000.0 -1.87 -2.1009 -0.9679 3118293 ChemDiv3_007042 CC(C)CCNC(=O)c1c(C)oc2C(=O)c3ccccc3C(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A03 compound treatment 103960.0 33100.0 0.55 111800.0 -10200.0 -0.16 0.2712 0.4757 1788862 ChemDiv3_007043 O=C(Nc1cccnc1)c2nc3ncccn3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A04 compound treatment 72000.0 1140.0 0.02 72520.0 -49500.0 -0.79 -0.5445 -0.6901 1875739 ChemDiv3_007044 OC(=O)c1ccc(NS(=O)(=O)c2cc3C(=O)NC(=O)c4cccc(c2)c43)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A05 compound treatment 7280.0 -63600.0 -1.05 5080.0 -117000.0 -1.86 -2.06 -0.9631 3027681 ChemDiv3_007045 COC(=O)CSC1=C(C#N)C(=O)NC(S1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A06 compound treatment 151200.0 80300.0 1.33 94280.0 -27700.0 -0.44 0.6251 0.4472 3118294 ChemDiv3_007046 COc1ccc2[nH]c(SCc3cnc(C)nc3N)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A07 compound treatment 173640.0 103000.0 1.7 38880.0 -83100.0 -1.33 0.2627 0.122 3027682 ChemDiv3_007047 CCSC1=C(C#N)C(=O)NC(CO)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A08 compound treatment 30680.0 -40200.0 -0.66 10640.0 -111000.0 -1.78 -1.7242 -0.9099 3118295 ChemDiv3_007048 Clc1ccc(cc1)C2C3=C(Nc4ccccc4S2(=O)=O)c5ccccc5C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A09 compound treatment 118720.0 47900.0 0.79 65760.0 -56300.0 -0.9 -0.0754 -0.0631 3118296 ChemDiv3_007049 CC1(C)OC[C@H](O1)[C@H](O)P(=O)(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A10 compound treatment 163480.0 92600.0 1.53 60040.0 -62000.0 -0.99 0.3826 0.2102 3027683 ChemDiv3_007050 CC(C)N1CNC(=NC1)Nc2nc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A11 compound treatment 173680.0 103000.0 1.7 66200.0 -55800.0 -0.89 0.5711 0.298 3118297 ChemDiv3_007051 CCOc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)N4C(C)CCCC4C)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A12 compound treatment 31320.0 -39500.0 -0.65 21200.0 -101000.0 -1.61 -1.5978 -0.9212 3027684 ChemDiv3_007052 CC(C)CCN1C(=O)c2ccc(cc2C1=O)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A13 compound treatment 172920.0 102000.0 1.68 97040.0 -25000.0 -0.4 0.9098 0.5256 3118298 ChemDiv3_007053 CCCn1cc(C(CC(=O)O)C(=O)O)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A14 compound treatment 156480.0 85600.0 1.41 117080.0 -4930.0 -0.08 0.9437 0.6667 1748461 ChemDiv3_007054 CCOC(=O)c1cnc(SCC(=O)N2CCc3ccccc23)nc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A15 compound treatment 104600.0 33700.0 0.56 74760.0 -47300.0 -0.75 -0.1388 -0.1482 3027685 ChemDiv3_007055 COc1ccc(cc1)N2CCc3c2n4c5ccccc5nc4c(C#N)c3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A16 compound treatment 86720.0 15900.0 0.26 38000.0 -84000.0 -1.34 -0.7618 -0.5583 3118299 ChemDiv3_007056 O=C(CSc1nc2ccccc2nc1N3CCOCC3)NCc4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A17 compound treatment 136840.0 66000.0 1.09 96520.0 -25500.0 -0.41 0.4828 0.4153 3027686 ChemDiv3_007057 Cn1c(=O)[nH]c(=O)c2n(CC=C)cnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A18 compound treatment 51160.0 -19700.0 -0.33 34280.0 -87700.0 -1.4 -1.2188 -0.8489 3118300 ChemDiv3_007058 Oc1ccc2c(CSc3cccc4cccnc34)cc(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A19 compound treatment 134280.0 63400.0 1.05 120600.0 -1410.0 -0.02 0.7243 0.6917 1612422 ChemDiv3_007059 Cc1cc(O)nc(SCc2cn3c(C)cc(C)nc3n2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A20 compound treatment 98760.0 27900.0 0.46 90880.0 -31100.0 -0.5 -0.0253 -0.0373 3027740 ChemDiv3_007060 CN(C)C1=NC(N=C(O1)c2ccccc2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A21 compound treatment 37280.0 -33600.0 -0.55 38960.0 -83100.0 -1.32 -1.328 -0.9254 3118301 ChemDiv3_007061 S1C(C(=Nc2ccccc12)c3ccccc3)c4nc5ccccc5[nH]4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A22 compound treatment 7560.0 -63300.0 -1.04 10080.0 -112000.0 -1.78 -2.0004 -0.9675 3027741 ChemDiv3_007062 CN(C)C1=NC(c2c(C)nn(c2O1)c3ccccc3)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A23 mock treatment 77200.0 6340.0 0.1 144840.0 22800.0 0.36 0.3312 0.875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 A24 mock treatment 35040.0 -35800.0 -0.59 149720.0 27700.0 0.44 -0.1059 -0.1435 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B01 compound treatment 4520.0 -66300.0 -1.1 4480.0 -118000.0 -1.87 -2.099 -0.9673 1198210 ChemDiv3_007063 Oc1c(ccc2cccnc12)C(N3CCCC3)c4ccncc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B02 compound treatment 137800.0 66900.0 1.1 140320.0 18300.0 0.29 0.9876 0.8642 1284982 ChemDiv3_007064 OCCNC(=O)c1ccc(cc1)N2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B03 compound treatment 6720.0 -64100.0 -1.06 6040.0 -116000.0 -1.85 -2.0558 -0.965 1247906 ChemDiv3_007065 CC(C)C(c1c(C)[nH]c2ccccc12)c3c(C)[nH]c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B04 compound treatment 154600.0 83700.0 1.38 111280.0 -10700.0 -0.17 0.8564 0.6149 3027742 ChemDiv3_007066 Cc1ccc(NC(=O)CSC(=N)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B05 compound treatment 100800.0 29900.0 0.49 89640.0 -32400.0 -0.52 -0.0154 -0.0216 3118302 ChemDiv3_007067 COc1ccc2cc(sc(=O)c2c1OC)C(=O)Nc3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B06 compound treatment 185600.0 115000.0 1.89 120600.0 -1410.0 -0.02 1.3233 0.6986 1627380 ChemDiv3_007068 CCN(CC)Cn1cnc2c(SC)ncnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B07 compound treatment 170880.0 100000.0 1.65 84440.0 -37600.0 -0.6 0.744 0.4236 3118303 ChemDiv3_007069 CC1(C)C2(C)CCC1(C(=O)O)c3nc4ccc5ncccc5c4nc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B08 compound treatment 137320.0 66500.0 1.1 47720.0 -74300.0 -1.18 -0.0616 -0.0382 3027743 ChemDiv3_007070 Clc1ccc(CC2(C(=O)c3ccccc3C2=O)c4ccc(Cl)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B09 compound treatment 69880.0 -984.0 -0.02 64560.0 -57500.0 -0.92 -0.659 -0.7195 3118304 ChemDiv3_007071 Cc1c(oc2CC(C)(C)CC(=O)c12)C(=O)N3CCc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B10 compound treatment 71880.0 1020.0 0.02 22160.0 -99900.0 -1.59 -1.1135 -0.6996 1618272 ChemDiv3_007072 CCN(CC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2ccc3OC(C)(C)Oc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B11 compound treatment 146600.0 75700.0 1.25 94960.0 -27100.0 -0.43 0.5791 0.4379 3027744 ChemDiv3_007073 Cc1ccc(cc1)S(=O)(=O)c2nc(c(NCc3ccco3)s2)S(=O)(=O)c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B12 compound treatment 29680.0 -41200.0 -0.68 18440.0 -104000.0 -1.65 -1.648 -0.9231 3118305 ChemDiv3_007074 COc1ccc(cc1)C(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B13 compound treatment 116920.0 46100.0 0.76 89480.0 -32500.0 -0.52 0.1709 0.1857 3118306 ChemDiv3_007075 COc1ccc(cc1)C2C(=C(N)Oc3cc(C)n(CCc4ccc(OC)c(OC)c4)c(=O)c23)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B14 compound treatment 94840.0 24000.0 0.4 17800.0 -104000.0 -1.66 -0.8947 -0.524 1516177 ChemDiv3_007076 O=C(NCc1ccc2OCOc2c1)c3ccc4c(=O)n(Cc5ccccc5)c(=S)[nH]c4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B15 compound treatment 157000.0 86100.0 1.42 124000.0 1990.0 0.03 1.0278 0.7227 3118307 ChemDiv3_007077 CN(C)CCn1c(C)cc2OC(=C(C#N)C(c3ccncc3)c2c1=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B16 compound treatment 143080.0 72200.0 1.19 92000.0 -30000.0 -0.48 0.5047 0.3929 3027745 ChemDiv3_007078 CCOc1ccc(NC(=O)CCNC(=O)c2cn(c3cccc(OC)c3)c(=O)c4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B17 compound treatment 179920.0 109000.0 1.8 76640.0 -45400.0 -0.72 0.7616 0.3926 3118308 ChemDiv3_007079 Fc1ccc(NP2(=O)COc3ccccc3OC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B18 compound treatment 149480.0 78600.0 1.3 95320.0 -26700.0 -0.43 0.6168 0.4516 3118309 ChemDiv3_007080 CC1(C)CC(=O)C2=C(C1)N(CCN3CCOCC3)C4=C(C2c5cccc(Cl)c5)C(=O)CC(C)(C)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B19 compound treatment 9080.0 -61800.0 -1.02 6640.0 -115000.0 -1.84 -2.0215 -0.9613 3027746 ChemDiv3_007081 CC[n+]1c(/C=C/2\SC=CN2C)cc(C)c3cc(OC)c4ccccc4c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B20 compound treatment 7680.0 -63200.0 -1.04 5800.0 -116000.0 -1.85 -2.0473 -0.9631 3118310 ChemDiv3_007082 CCOC(=O)c1cnc2c(OC)cccc2c1N3CC(C)CC(C)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B21 compound treatment 31160.0 -39700.0 -0.66 68520.0 -53500.0 -0.85 -1.0663 -0.9916 3027747 ChemDiv3_007083 S(c1ccc(/C=N/c2cccc3ccccc23)o1)c4nnnn4c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B22 compound treatment 83000.0 12100.0 0.2 49000.0 -73000.0 -1.16 -0.6812 -0.5769 3118432 ChemDiv3_007084 CCOc1ccc2n(CC)/c(=N/C(=O)c3ccc(cc3)S(=O)(=O)N4CCCCC4C)/sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B23 mock treatment 115040.0 44200.0 0.73 116000.0 -6010.0 -0.1 0.4479 0.6089 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 B24 mock treatment 79080.0 8220.0 0.14 122680.0 666.0 0.01 0.1034 0.7601 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C01 compound treatment 125440.0 54600.0 0.9 116120.0 -5890.0 -0.09 0.5706 0.63 3027748 ChemDiv3_007085 FC(F)(F)c1cc(nc(OCC(=O)NCC=C)n1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C02 compound treatment 6160.0 -64700.0 -1.07 5520.0 -116000.0 -1.86 -2.0682 -0.9655 3118433 ChemDiv3_007086 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C03 compound treatment 91360.0 20500.0 0.34 70800.0 -51200.0 -0.82 -0.338 -0.3825 1788886 ChemDiv3_007087 CCOC(=O)c1c(NC(=O)c2nc3ncccn3n2)sc4CC(CC)CCc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C04 compound treatment 118960.0 48100.0 0.79 107760.0 -14300.0 -0.23 0.4008 0.4853 3027749 ChemDiv3_007088 OC(=O)CCC(=O)N(Cc1cn(nc1c2cccnc2)c3ccccc3)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C05 compound treatment 56440.0 -14400.0 -0.24 35080.0 -86900.0 -1.39 -1.1481 -0.8166 3118434 ChemDiv3_007089 COC(=O)CSC1=C(C#N)C(=O)NC(S1)c2ccccc2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C06 compound treatment 9160.0 -61700.0 -1.02 6440.0 -116000.0 -1.84 -2.0228 -0.961 3027750 ChemDiv3_007090 Cc1ccc(cc1)n2sc3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C07 compound treatment 11760.0 -59100.0 -0.98 6760.0 -115000.0 -1.84 -1.9888 -0.9562 3118435 ChemDiv3_007091 Oc1ccccc1C2NC(=O)C(=C(SCc3ccccc3)S2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C08 compound treatment 168160.0 97300.0 1.61 99720.0 -22300.0 -0.36 0.8844 0.5377 3027751 ChemDiv3_007092 Cn1c2NCN(Cc2c(=O)n(C)c1=O)C3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C09 compound treatment 92120.0 21300.0 0.35 35960.0 -86100.0 -1.37 -0.7217 -0.5098 1528851 ChemDiv3_007093 CCOc1cccc2cc(c3nc4ccccc4s3)c(=O)oc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C10 compound treatment 148960.0 78100.0 1.29 71480.0 -50500.0 -0.81 0.342 0.225 3118436 ChemDiv3_007094 C1NC(=NCN1C2CCCCCC2)Nc3nc4ccccc4s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C11 compound treatment 172160.0 101000.0 1.67 123200.0 1190.0 0.02 1.1957 0.7151 3027752 ChemDiv3_007095 CCN(CC)C(=O)C1Sc2nnc(c3ccccc3)n2NC1c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C12 compound treatment 132760.0 61900.0 1.02 80200.0 -41800.0 -0.67 0.2512 0.2059 3118437 ChemDiv3_007096 CCC(=O)c1cn(CC(=O)NCCOc2ccc(Cl)cc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C13 compound treatment 132960.0 62100.0 1.03 110200.0 -11800.0 -0.19 0.5917 0.5677 3118438 ChemDiv3_007097 COc1ccc(cc1)N2C(=O)CC(C2=O)c3cn(Cc4ccccc4)c5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C14 compound treatment 74000.0 3140.0 0.05 48640.0 -73400.0 -1.17 -0.7903 -0.6751 3027753 ChemDiv3_007098 Nc1c(C#N)cnc2c(c(COc3ccccc3)nn12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C15 compound treatment 161200.0 90300.0 1.49 153760.0 31700.0 0.51 1.4122 0.8968 3027754 ChemDiv3_007099 CC1=NNC(=O)C1CCc2ccncc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C16 compound treatment 69800.0 -1060.0 -0.02 74920.0 -47100.0 -0.75 -0.5432 -0.7235 3118439 ChemDiv3_007100 O=C(CSc1nc2ccccc2nc1N3CCOCC3)N4CCC5(CC4)OCCO5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C17 compound treatment 165760.0 94900.0 1.57 107480.0 -14500.0 -0.23 0.9439 0.5961 3027755 ChemDiv3_007101 CSc1ccn(Cc2ccc(Cl)cc2)c(=O)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C18 compound treatment 162760.0 91900.0 1.52 96800.0 -25200.0 -0.4 0.7885 0.5024 3118440 ChemDiv3_007102 CCCOc1ccc(cc1)/C(=N\O)/C(C)(C)NO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C19 compound treatment 165560.0 94700.0 1.56 119440.0 -2570.0 -0.04 1.0763 0.6883 3118441 ChemDiv3_007103 CCS(=O)(=O)Nc1cccc(c1)C(=O)CC2(O)C(=O)Nc3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C20 compound treatment 153680.0 82800.0 1.37 131680.0 9670.0 0.15 1.0756 0.7818 3026802 ChemDiv3_007104 CC1=CC2=NC(NC(=O)N2C=C1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C21 compound treatment 117840.0 47000.0 0.78 96160.0 -25900.0 -0.41 0.2569 0.2926 3026803 ChemDiv3_007105 CCOc1ccc(cc1)C2C3=C(CCCC3=O)Nc4ncnn24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C22 compound treatment 102560.0 31700.0 0.52 116080.0 -5930.0 -0.09 0.3031 0.5701 3118442 ChemDiv3_007106 CCC1=NC(C2=C(CC(C)(C)CC2=O)N1Cc3ccccc3)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C23 mock treatment 105400.0 34500.0 0.57 106680.0 -15300.0 -0.24 0.2303 0.3713 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 C24 mock treatment 86200.0 15300.0 0.25 129080.0 7070.0 0.11 0.2586 0.9335 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D01 compound treatment 4200.0 -66700.0 -1.1 3560.0 -118000.0 -1.89 -2.1131 -0.967 1621903 ChemDiv3_007107 CN1CCN(CC1)C(c2c(C)[nH]c3ccccc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D02 compound treatment 90680.0 19800.0 0.33 98040.0 -24000.0 -0.38 -0.0389 -0.0773 3026804 ChemDiv3_007108 Cc1ccsc1/C=N/c2ccc(Cl)cc2C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D03 compound treatment 91520.0 20700.0 0.34 107520.0 -14500.0 -0.23 0.0778 0.1888 1681432 ChemDiv3_007109 Cc1ccc(cc1)C(=O)OC(c2ccccc2)c3nccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D04 compound treatment 7600.0 -63300.0 -1.04 12360.0 -110000.0 -1.75 -1.9743 -0.9697 1346036 ChemDiv3_007110 CCOc1nc(NC2CCCC2)nc(n1)N3CCC(C)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D05 compound treatment 90680.0 19800.0 0.33 70240.0 -51800.0 -0.83 -0.3522 -0.3968 3118443 ChemDiv3_007111 Cc1sc2N(CN(Cc2c1C)C(C)(C)C)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D06 compound treatment 164760.0 93900.0 1.55 164440.0 42400.0 0.68 1.5741 0.9309 1643537 ChemDiv3_007112 CCOC(=O)N1N=C(C)CC1(O)c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D07 compound treatment 183360.0 112000.0 1.86 122800.0 786.0 0.01 1.322 0.7119 3118444 ChemDiv3_007113 O(c1ccc2nccnc2c1)c3ccc4nccnc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D08 compound treatment 176280.0 105000.0 1.74 117520.0 -4490.0 -0.07 1.1798 0.6774 3026805 ChemDiv3_007114 CN(C)c1ccc(cc1)c2nc(S)[nH]c(=O)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D09 compound treatment 122440.0 51600.0 0.85 93920.0 -28100.0 -0.45 0.2854 0.2967 3118445 ChemDiv3_007115 CN1CCN(CC1)C(=O)c2oc3CC(C)(C)CC(=O)c3c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D10 compound treatment 165000.0 94100.0 1.55 153960.0 31900.0 0.51 1.4588 0.8921 1345726 ChemDiv3_007116 CC(C)(C)N1NC2(CCCCC2)NC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D11 compound treatment 14240.0 -56600.0 -0.93 9920.0 -112000.0 -1.79 -1.9243 -0.9543 1384630 ChemDiv3_007117 CC(C)(C)c1cc(cc(c1O)C(C)(C)C)C(N2CCOCC2)c3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D12 compound treatment 126760.0 55900.0 0.92 125000.0 2990.0 0.05 0.6861 0.7426 3118446 ChemDiv3_007118 Cc1ccccc1NC(=O)c2cnn3c(cc(nc23)c4ccco4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D13 compound treatment 170720.0 99900.0 1.65 175200.0 53200.0 0.85 1.765 0.9522 1444379 ChemDiv3_007119 COC(=O)C1=C(N)Oc2cc(C)oc(=O)c2C1c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D14 compound treatment 193040.0 122000.0 2.02 165800.0 43800.0 0.7 1.9196 0.8995 1441733 ChemDiv3_007120 COc1ccc(NC(=O)c2ccc3c(=O)n(CCc4ccccc4)c(=S)[nH]c3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D15 compound treatment 150320.0 79500.0 1.31 117520.0 -4490.0 -0.07 0.8768 0.6675 3026806 ChemDiv3_007121 COC(=O)C1=C(N)Oc2cc(C)n(Cc3ccccc3)c(=O)c2C1c4ccncc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D16 compound treatment 147720.0 76900.0 1.27 124320.0 2310.0 0.04 0.9231 0.7273 3118447 ChemDiv3_007122 COc1ccccc1n2cc(C(=O)NCC(=O)NCC3COc4ccccc4O3)c5ccccc5c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D17 compound treatment 143800.0 72900.0 1.2 107040.0 -15000.0 -0.24 0.6826 0.5561 3026807 ChemDiv3_007123 Clc1ccc(cc1)N2CCN(CC2)P3(=O)COc4ccccc4OC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D18 compound treatment 147040.0 76200.0 1.26 56040.0 -66000.0 -1.05 0.1456 0.0888 3118448 ChemDiv3_007124 Nc1cc(OC(=O)c2ccccc2)nn1S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D19 compound treatment 16000.0 -54900.0 -0.91 8520.0 -113000.0 -1.81 -1.9195 -0.9488 3026808 ChemDiv3_007125 COc1ccc2N(C)/C(=C/c3sc4ccccc4[n+]3C)/C=Cc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D20 compound treatment 107680.0 36800.0 0.61 48120.0 -73900.0 -1.18 -0.4031 -0.3041 3118449 ChemDiv3_007126 CCOC(=O)c1cnc2ccc(OCC)cc2c1NC(C)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D21 compound treatment 121840.0 51000.0 0.84 93680.0 -28300.0 -0.45 0.2757 0.2887 1344877 ChemDiv3_007127 O=C(C1CN(C(=O)C1)c2ccccc2)N(Cc3ccccc3)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D22 compound treatment 54960.0 -15900.0 -0.26 55840.0 -66200.0 -1.05 -0.9314 -0.857 3026809 ChemDiv3_007128 CCn1/c(=N/C(=O)c2ccc(cc2)S(=O)(=O)N(C)C)/sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D23 mock treatment 112640.0 41800.0 0.69 133680.0 11700.0 0.19 0.6191 0.8668 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 D24 mock treatment 86600.0 15700.0 0.26 94640.0 -27400.0 -0.44 -0.1248 -0.2458 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E01 compound treatment 84440.0 13600.0 0.22 60280.0 -61700.0 -0.98 -0.5373 -0.5324 3118450 ChemDiv3_007129 CC1CCN(C(C)C1)C(=O)c2cc3nc(cc(n3n2)C(F)(F)F)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E02 compound treatment 4680.0 -66200.0 -1.09 5440.0 -117000.0 -1.86 -2.0863 -0.968 3026810 ChemDiv3_007130 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NC4CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E03 compound treatment 59480.0 -11400.0 -0.19 66920.0 -55100.0 -0.88 -0.7538 -0.8394 3118451 ChemDiv3_007131 CN(C1CCCCC1)C(=O)c2cc3nc(cc(n3n2)C(F)(F)F)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E04 compound treatment 28520.0 -42300.0 -0.7 28080.0 -93900.0 -1.5 -1.5529 -0.9399 3118452 ChemDiv3_007132 CCc1nc(SCS(=O)(=O)c2ccc(C)cc2)c(C#N)c3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E05 compound treatment 7920.0 -62900.0 -1.04 6680.0 -115000.0 -1.84 -2.0345 -0.9635 3026811 ChemDiv3_007133 CCSC1=C(C#N)C(=O)NC(S1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E06 compound treatment 152200.0 81300.0 1.34 144760.0 22700.0 0.36 1.2057 0.867 3118573 ChemDiv3_007134 OC(=O)c1ccn(Cn2cnc3ccccc23)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E07 compound treatment 16240.0 -54600.0 -0.9 10760.0 -111000.0 -1.77 -1.8914 -0.9508 3026812 ChemDiv3_007135 CC1NC(=O)C(=C(SCc2ccccc2)S1)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E08 compound treatment 133720.0 62900.0 1.04 134840.0 12800.0 0.2 0.8782 0.8305 3118574 ChemDiv3_007136 Clc1cccc(NC(=O)CC2N(CCNC2=O)C(=O)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E09 compound treatment 152920.0 82100.0 1.35 117480.0 -4530.0 -0.07 0.9067 0.6684 3118575 ChemDiv3_007137 COc1ccc(cc1Cl)C2Nn3c(C)nnc3SC2C(=O)NCc4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E10 compound treatment 107680.0 36800.0 0.61 66800.0 -55200.0 -0.88 -0.1925 -0.18 3026813 ChemDiv3_007138 Clc1ccc(SCc2cc(=O)[nH]c(n2)N3CCN(Cc4ccc5OCOc5c4)CC3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E11 compound treatment 168200.0 97300.0 1.61 125760.0 3750.0 0.06 1.1784 0.7329 3118576 ChemDiv3_007139 Cc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)NCC4CCCO4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E12 compound treatment 127080.0 56200.0 0.93 133800.0 11800.0 0.19 0.789 0.8333 3026814 ChemDiv3_007140 CCOC(=O)C(C)N1c2cccc3cccc(c23)S1(=O)=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E13 compound treatment 159920.0 89100.0 1.47 151920.0 29900.0 0.48 1.3765 0.8907 3118577 ChemDiv3_007141 CC(C)CN1CC(CC1=O)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E14 compound treatment 146600.0 75700.0 1.25 148520.0 26500.0 0.42 1.1828 0.8963 3026815 ChemDiv3_007142 Clc1ccc2OCC(=O)N(CC(=O)N3CCCC3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E15 compound treatment 143760.0 72900.0 1.2 135760.0 13700.0 0.22 1.0058 0.8223 1116771 ChemDiv3_007143 OC(=O)Cc1nc2ccccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E16 compound treatment 104880.0 34000.0 0.56 67880.0 -54100.0 -0.86 -0.213 -0.207 3118578 ChemDiv3_007144 Clc1ccc(CCNC(=O)CSc2nc3ccccc3nc2N4CCCC4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E17 compound treatment 143840.0 73000.0 1.2 140880.0 18900.0 0.3 1.0644 0.8573 1549546 ChemDiv3_007145 Cn1c(NCc2ccco2)nc3n(C)c(=O)n(C)c(=O)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E18 compound treatment 156400.0 85500.0 1.41 138200.0 16200.0 0.26 1.1808 0.8227 3118579 ChemDiv3_007146 Cc1ccc2c(C)nc(NC(=N)NS(=O)(=O)c3ccccc3)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E19 compound treatment 121400.0 50500.0 0.83 104800.0 -17200.0 -0.27 0.3959 0.4508 3026816 ChemDiv3_007147 COc1ccc(NC(=O)C(C)C2SC(=O)NC2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E20 compound treatment 122400.0 51500.0 0.85 137720.0 15700.0 0.25 0.7786 0.878 3118580 ChemDiv3_007148 Cc1cccc(c1)C2=NC(c3c(N2)n(C)c(=O)n(C)c3=O)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E21 compound treatment 103080.0 32200.0 0.53 109160.0 -12900.0 -0.2 0.2312 0.4056 3026817 ChemDiv3_007149 CCC1=C(C(c2ccc(Br)cc2)n3ncnc3N1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E22 compound treatment 121520.0 50700.0 0.84 113720.0 -8290.0 -0.13 0.4978 0.588 3118581 ChemDiv3_007150 CC1(C)CC(=O)C2=C(C1)N(Cc3ccco3)C(=O)NC2(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E23 mock treatment 95520.0 24700.0 0.41 118640.0 -3370.0 -0.05 0.2498 0.6084 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 E24 mock treatment 90840.0 20000.0 0.33 76880.0 -45100.0 -0.72 -0.2755 -0.3481 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F01 compound treatment 8640.0 -62200.0 -1.03 13760.0 -108000.0 -1.73 -1.9463 -0.9693 1293985 ChemDiv3_007151 Oc1c(ccc2cccnc12)C(Nc3cccc(Cl)c3)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F02 compound treatment 55360.0 -15500.0 -0.26 51800.0 -70200.0 -1.12 -0.9723 -0.8469 3118582 ChemDiv3_007152 CC(NC(=O)CSc1nc2ccc(/N=C/c3ccccc3O)cc2s1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F03 compound treatment 90120.0 19300.0 0.32 117120.0 -4890.0 -0.08 0.1696 0.5182 1225945 ChemDiv3_007153 OC1(CCN(CC1C(=O)c2ccccc2)C3CCS(=O)(=O)C3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F04 compound treatment 37320.0 -33500.0 -0.55 57440.0 -64600.0 -1.03 -1.1193 -0.9577 3118583 ChemDiv3_007154 O=C(CSc1nc2ccc(cc2s1)N3C(=O)c4ccccc4C3=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F05 compound treatment 84400.0 13500.0 0.22 67680.0 -54300.0 -0.87 -0.4544 -0.508 3026871 ChemDiv3_007155 CCN(CC)CCN1CN(C(=O)c2ccccc2)c3sc(C)c(C)c3C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F06 compound treatment 10240.0 -60600.0 -1.0 8560.0 -113000.0 -1.81 -1.9863 -0.9611 3118584 ChemDiv3_007156 CCOc1ccc(cc1)N2C(=O)/C(=C/c3cccs3)/C(=O)N(C2=S)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F07 compound treatment 115200.0 44300.0 0.73 97320.0 -24700.0 -0.39 0.2392 0.2879 1868012 ChemDiv3_007157 CNC(=O)Cc1coc2ccc3ccccc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F08 compound treatment 154920.0 84100.0 1.39 142760.0 20700.0 0.33 1.215 0.8518 3118585 ChemDiv3_007158 O=C(CSc1ncccn1)Nc2nccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F09 compound treatment 77880.0 7020.0 0.12 75040.0 -47000.0 -0.75 -0.4475 -0.5907 3026872 ChemDiv3_007159 Cc1ccc2cc3CCN(Cc4ccco4)c3nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F10 compound treatment 10440.0 -60400.0 -1.0 8680.0 -113000.0 -1.81 -1.9826 -0.9608 3118586 ChemDiv3_007160 CCOc1cccc(NC(=O)C2CC(=O)N(/N=C(\C)/c3ccc(Br)s3)C(=N)S2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F11 compound treatment 10360.0 -60500.0 -1.0 9320.0 -113000.0 -1.8 -1.9763 -0.9616 3118587 ChemDiv3_007161 CCOC(=O)c1ccc2nc(nc(NCCCc3ccccc3)c2c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F12 compound treatment 18160.0 -52700.0 -0.87 19240.0 -103000.0 -1.64 -1.7735 -0.9562 1635368 ChemDiv3_007162 O=C(NCc1ccccc1)c2ccc3c(=O)n(CCc4ccccc4)c(SCC#N)nc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F13 compound treatment 120040.0 49200.0 0.81 120320.0 -1690.0 -0.03 0.5549 0.6832 3118588 ChemDiv3_007163 Cc1cc2OC(=C(C#N)C(c3cccc(F)c3)c2c(=O)n1CCN4CCOCC4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F14 compound treatment 134280.0 63400.0 1.05 114640.0 -7370.0 -0.12 0.6571 0.6238 1650732 ChemDiv3_007164 COc1ccc(OC)c(c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)NCc4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F15 compound treatment 94320.0 23500.0 0.39 55720.0 -66300.0 -1.06 -0.4734 -0.4206 3026873 ChemDiv3_007165 CC(C)c1ccc(cc1)C2C(=C(N)Oc3cc(C)[nH]c(=O)c23)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F16 compound treatment 133560.0 62700.0 1.03 125040.0 3030.0 0.05 0.7659 0.7393 1236286 ChemDiv3_007166 O=C(CCN1C(=O)C2CC=CCC2C1=O)N3CCN(CC3)c4ccccn4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F17 compound treatment 163080.0 92200.0 1.52 153800.0 31800.0 0.51 1.4346 0.8942 3026874 ChemDiv3_007167 O=P1(COc2ccccc2OC1)Nc3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F18 compound treatment 94080.0 23200.0 0.38 96720.0 -25300.0 -0.4 -0.0141 -0.0253 3026875 ChemDiv3_007168 COc1ccc(cc1)S(=O)(=O)n2nc(OC(=O)C(C)(C)C)cc2N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F19 compound treatment 158520.0 87700.0 1.45 151120.0 29100.0 0.46 1.3512 0.8892 3118589 ChemDiv3_007169 COc1cccc(c1)C(=O)NC(NCC2CCCO2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F20 compound treatment 15360.0 -55500.0 -0.92 15280.0 -107000.0 -1.7 -1.8508 -0.9579 1723594 ChemDiv3_007170 CCOC(=O)c1cnc2ccc(OCC)cc2c1N(C)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F21 compound treatment 110440.0 39600.0 0.65 132240.0 10200.0 0.16 0.5772 0.8572 1579177 ChemDiv3_007171 OP(=O)(CN1CCCCC1)CN2CCCCCC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F22 compound treatment 114280.0 43400.0 0.72 125480.0 3470.0 0.06 0.5458 0.7594 3118590 ChemDiv3_007172 CC1CN(CC(C)O1)S(=O)(=O)c2ccc(cc2)C(=O)/N=c\3/sc4cccc(Cl)c4n3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F23 mock treatment 100440.0 29600.0 0.49 126120.0 4110.0 0.07 0.3915 0.7948 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 F24 mock treatment 103400.0 32500.0 0.54 96680.0 -25300.0 -0.4 0.0943 0.1403 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G01 compound treatment 57280.0 -13600.0 -0.22 65680.0 -56300.0 -0.9 -0.7934 -0.8574 3026876 ChemDiv3_007173 COc1ccc(cc1OC)c2cc(nc(SCC(=O)N3CCCCCC3)n2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G02 compound treatment 4080.0 -66800.0 -1.1 5480.0 -117000.0 -1.86 -2.0929 -0.969 3118591 ChemDiv3_007174 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NCCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G03 compound treatment 38320.0 -32500.0 -0.54 56200.0 -65800.0 -1.05 -1.1216 -0.9517 3026877 ChemDiv3_007175 CSc1ccccc1NC(=O)c2cnn3c(cc(nc23)c4ccco4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G04 compound treatment 119800.0 48900.0 0.81 120320.0 -1690.0 -0.03 0.5521 0.6831 3118592 ChemDiv3_007176 CC1(C)CC(CCO1)N(Cc2cccs2)C(=O)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G05 compound treatment 14080.0 -56800.0 -0.94 10240.0 -112000.0 -1.78 -1.9225 -0.955 3118593 ChemDiv3_007177 CCSC1=C(C#N)C(=O)NC(S1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G06 compound treatment 161520.0 90700.0 1.5 136160.0 14100.0 0.23 1.2176 0.8046 3026878 ChemDiv3_007178 OC(=O)/C=C/c1ccc2c(onc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G07 compound treatment 135280.0 64400.0 1.06 133600.0 11600.0 0.18 0.8825 0.8177 3118594 ChemDiv3_007179 Cc1csc2nc(=O)c(nn12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G08 compound treatment 140760.0 69900.0 1.15 155120.0 33100.0 0.53 1.189 0.9371 3026879 ChemDiv3_007180 CC(=O)NC1C(=O)Nc2c1cccc2C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G09 compound treatment 87960.0 17100.0 0.28 79960.0 -42100.0 -0.67 -0.2744 -0.3773 3118595 ChemDiv3_007181 Cc1cccc(NC(=O)C2Sc3nnc(c4ccccc4)n3NC2c5ccccc5)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G10 compound treatment 141280.0 70400.0 1.16 128640.0 6630.0 0.11 0.8966 0.7682 3118596 ChemDiv3_007182 CCC(=O)N1CCNC(=O)C1CC(=O)Nc2ccc(C)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G11 compound treatment 127160.0 56300.0 0.93 120320.0 -1690.0 -0.03 0.638 0.6863 1170868 ChemDiv3_007183 Cn1c(=O)c(Nc2ccccc2)c3-c4ccccc4C(=O)c5cccc1c53 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G12 compound treatment 99160.0 28300.0 0.47 120960.0 -1050.0 -0.02 0.3184 0.6812 3026880 ChemDiv3_007184 CCc1nnc2sc(nn12)c3ccc(N)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G13 compound treatment 95480.0 24600.0 0.41 97320.0 -24700.0 -0.39 0.009 0.016 3118721 ChemDiv3_007185 CC(C)(CO)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G14 compound treatment 79160.0 8300.0 0.14 82920.0 -39100.0 -0.62 -0.3438 -0.5388 3118722 ChemDiv3_007186 Cn1cccc1CNCCc2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G15 compound treatment 135920.0 65100.0 1.07 156840.0 34800.0 0.56 1.1519 0.9528 3026881 ChemDiv3_007187 Oc1cccnc1NC(=O)CCC2COc3ccccc3O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G16 compound treatment 64120.0 -6740.0 -0.11 79760.0 -42300.0 -0.67 -0.5549 -0.813 3118723 ChemDiv3_007188 CC1CN(CC(C)O1)c2nc3ccccc3nc2SCC(=O)NCc4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G17 compound treatment 67920.0 -2940.0 -0.05 69360.0 -52700.0 -0.84 -0.6278 -0.7468 3118724 ChemDiv3_007189 Cc1ccc(NC(=O)c2ccc(CSc3ncnc4[nH]cnc34)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G18 compound treatment 133560.0 62700.0 1.03 129960.0 7950.0 0.13 0.8214 0.7878 3026882 ChemDiv3_007190 CCOC(=O)c1cnc(Nc2nc3ccccc3s2)nc1CSc4ncccn4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G19 compound treatment 151400.0 80500.0 1.33 153360.0 31300.0 0.5 1.2933 0.9107 3118725 ChemDiv3_007191 CC(C1SC(=O)NC1=O)C(=O)Nc2nccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G20 compound treatment 110240.0 39400.0 0.65 115240.0 -6770.0 -0.11 0.3833 0.5817 3026883 ChemDiv3_007192 FC(F)(F)C1(N=C(NC(=N1)c2ccccc2)c3ccccc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G21 compound treatment 148640.0 77800.0 1.28 120880.0 -1130.0 -0.02 0.8951 0.6971 3026933 ChemDiv3_007193 NC(=O)c1cc(C(=O)Nc2ccccc2)c(N)nc1SCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G22 compound treatment 49720.0 -21100.0 -0.35 47120.0 -74900.0 -1.19 -1.0909 -0.8771 3118726 ChemDiv3_007194 CC1=C(C#N)C(N=C(N1)C2CCCCC2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G23 mock treatment 85160.0 14300.0 0.24 120240.0 -1770.0 -0.03 0.1469 0.618 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 G24 mock treatment 67640.0 -3220.0 -0.05 111680.0 -10300.0 -0.16 -0.1541 -0.8903 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H01 compound treatment 3040.0 -67800.0 -1.12 3640.0 -118000.0 -1.89 -2.1258 -0.969 1322971 ChemDiv3_007195 CC(C)c1ccc(cc1)C(Nc2nccs2)c3c(C)[nH]c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H02 compound treatment 72040.0 1180.0 0.02 92080.0 -29900.0 -0.48 -0.3236 -0.6778 3118727 ChemDiv3_007196 Cc1ccc(cc1)N(CC(=O)NCc2ccco2)S(=O)(=O)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H03 compound treatment 71680.0 816.0 0.01 119120.0 -2890.0 -0.05 -0.0231 -0.4805 1679882 ChemDiv3_007197 Cc1[nH]c2ccccc2c1C(O)c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H04 compound treatment 90800.0 19900.0 0.33 127320.0 5310.0 0.08 0.2925 0.8609 3118728 ChemDiv3_007198 COc1ccc(CN/C(=N\c2ccccc2)/SC3CC(=O)NC3=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H05 compound treatment 76520.0 5660.0 0.09 114240.0 -7770.0 -0.12 -0.0216 -0.1392 3118729 ChemDiv3_007199 Cc1sc2N(CN(Cc3ccco3)Cc2c1C)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H06 compound treatment 44320.0 -26500.0 -0.44 47240.0 -74800.0 -1.19 -1.1525 -0.9077 3026934 ChemDiv3_007200 CCN1C(=O)/C(=C\C=C\2/Sc3ccc(Cl)cc3N2C)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H07 compound treatment 115120.0 44300.0 0.73 134880.0 12900.0 0.21 0.6616 0.8719 3118730 ChemDiv3_007201 Cc1ccc2cc3CCN(c3nc2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H08 compound treatment 36520.0 -34300.0 -0.57 56520.0 -65500.0 -1.04 -1.139 -0.9589 1574479 ChemDiv3_007202 O=C(CCSc1ccccc1)NC2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H09 compound treatment 22000.0 -48900.0 -0.81 24720.0 -97300.0 -1.55 -1.6669 -0.9536 3118731 ChemDiv3_007203 Cc1ccc2cc3CCN(c3nc2c1)c4ccc(cc4)C(=O)NCc5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H10 compound treatment 91520.0 20700.0 0.34 110800.0 -11200.0 -0.18 0.1147 0.298 1738369 ChemDiv3_007204 CCC(NC(=O)c1cc(OC)c(OC)c(OC)c1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H11 compound treatment 132040.0 61200.0 1.01 136120.0 14100.0 0.22 0.8731 0.8439 3026935 ChemDiv3_007205 CCOC(=O)c1ccc2nc(nc(N3CC(C)OC(C)C3)c2c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H12 compound treatment 99720.0 28900.0 0.48 116000.0 -6010.0 -0.1 0.269 0.5537 1558178 ChemDiv3_007206 CCCCn1c(SCC(=O)OCC)nc2n(CCc3ccccc3)c(=S)sc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H13 compound treatment 91800.0 20900.0 0.35 96640.0 -25400.0 -0.4 -0.0416 -0.0782 3118732 ChemDiv3_007207 Cc1cc2OC(=C(C#N)C(c3ccccc3)c2c(=O)n1CCCn4ccnc4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H14 compound treatment 73360.0 2500.0 0.04 86040.0 -36000.0 -0.57 -0.3763 -0.6546 1230528 ChemDiv3_007208 COc1ccc(OC)c(c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)Nc4ccc(C)c(Cl)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H15 compound treatment 79360.0 8500.0 0.14 101560.0 -20500.0 -0.33 -0.1313 -0.3701 3118733 ChemDiv3_007209 N(c1ccccc1)c2ccc(nn2)n3ccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H16 compound treatment 25080.0 -45800.0 -0.76 62320.0 -59700.0 -0.95 -1.2072 -0.9935 3026936 ChemDiv3_007210 CC(C)c1ccc(NC(=O)c2coc(=O)c3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H17 compound treatment 137440.0 66600.0 1.1 132120.0 10100.0 0.16 0.891 0.8022 3118734 ChemDiv3_007211 CC(C)c1ccc(C)c(OP2(=O)COc3ccccc3OC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H18 compound treatment 32280.0 -38600.0 -0.64 87160.0 -34900.0 -0.56 -0.8432 -0.9977 3026937 ChemDiv3_007212 CCOC(=O)c1cnc2cc(ccc2c1N(C)Cc3ccccc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H19 compound treatment 12520.0 -58300.0 -0.96 18320.0 -104000.0 -1.65 -1.8497 -0.967 3118735 ChemDiv3_007213 Cc1ccc(NC(=O)c2cccc(OC(=S)NCc3ccccc3)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H20 compound treatment 70680.0 -184.0 0.0 63800.0 -58200.0 -0.93 -0.6582 -0.7094 3118736 ChemDiv3_007214 CCOC(=O)c1cnc2ccc(OCC)cc2c1N3CCN(CC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H21 compound treatment 8120.0 -62700.0 -1.04 8040.0 -114000.0 -1.82 -2.0169 -0.9645 3026938 ChemDiv3_007215 Cc1ccccc1/N=C/c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H22 compound treatment 56600.0 -14300.0 -0.24 66720.0 -55300.0 -0.88 -0.7897 -0.8657 3118737 ChemDiv3_007216 CCn1/c(=N\C(=O)c2ccc(cc2)S(=O)(=O)N3CCCC3)/sc4c1ccc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H23 mock treatment 124200.0 53300.0 0.88 124880.0 2870.0 0.05 0.6549 0.7428 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 H24 mock treatment 42040.0 -28800.0 -0.48 101040.0 -21000.0 -0.33 -0.5728 -0.9851 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I01 compound treatment 2400.0 -68500.0 -1.13 5000.0 -117000.0 -1.87 -2.1179 -0.9712 3026939 ChemDiv3_007217 COc1ccc(cc1OC)c2cc(nc(SCC(=O)N3CCc4ccccc34)n2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I02 compound treatment 3600.0 -67300.0 -1.11 5440.0 -117000.0 -1.86 -2.0989 -0.9697 3118738 ChemDiv3_007218 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)NCCCn4ccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I03 compound treatment 85680.0 14800.0 0.24 123120.0 1110.0 0.02 0.1854 0.7561 3026940 ChemDiv3_007219 Cc1cc(nc(SCc2ccc(o2)C(=O)O)n1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I04 compound treatment 71640.0 776.0 0.01 100360.0 -21700.0 -0.35 -0.235 -0.6804 3118739 ChemDiv3_007220 COc1ccc(Br)cc1C(=O)N2Cc3cc(OC)c(OC)cc3C4(CCCC4)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I05 compound treatment 6800.0 -64100.0 -1.06 10040.0 -112000.0 -1.78 -2.0097 -0.9688 3026941 ChemDiv3_007221 CCSC1=C(C#N)C(=O)NC(S1)c2ccc(OC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I06 compound treatment 81160.0 10300.0 0.17 99200.0 -22800.0 -0.36 -0.1369 -0.3412 3118740 ChemDiv3_007222 Clc1ccc(cc1)c2onc3cc(ccc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I07 compound treatment 12280.0 -58600.0 -0.97 14800.0 -107000.0 -1.71 -1.8921 -0.9637 3026942 ChemDiv3_007223 O=C/1Nc2ccccc2\C1=C\C=C\c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I08 compound treatment 55840.0 -15000.0 -0.25 88760.0 -33300.0 -0.53 -0.5501 -0.9401 3118741 ChemDiv3_007224 CCCn1c2ccc(C)cc2c3nnc(SCCN4CCOCC4)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I09 compound treatment 119880.0 49000.0 0.81 129280.0 7270.0 0.12 0.654 0.8002 3118742 ChemDiv3_007225 O=C(C1Sc2nnc(c3ccccc3)n2NC1c4ccccc4)N5CCCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I10 compound treatment 124320.0 53500.0 0.88 144280.0 22300.0 0.35 0.8749 0.9199 3026943 ChemDiv3_007226 CCC(=O)N1C(CC(=O)Nc2ccc(F)cc2)C(=O)NC3CCCCC31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I11 compound treatment 33360.0 -37500.0 -0.62 37720.0 -84300.0 -1.34 -1.3878 -0.9381 1866671 ChemDiv3_007227 O=C1c2ccccc2-c3c(NCCc4ccccc4)c(=O)[nH]c5cccc1c35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I12 compound treatment 56400.0 -14500.0 -0.24 41080.0 -80900.0 -1.29 -1.081 -0.824 3118743 ChemDiv3_007228 COC(=O)C1=C(C)OC(=C(C#N)C1c2cc(C)cc(Cn3ccc(n3)C(F)(F)F)c2C)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I13 compound treatment 101800.0 30900.0 0.51 123760.0 1750.0 0.03 0.3808 0.7445 3026944 ChemDiv3_007229 Nc1cccc(c1)c2ccc(CO)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I14 compound treatment 105880.0 35000.0 0.58 123440.0 1430.0 0.02 0.4248 0.7343 3118744 ChemDiv3_007230 COc1ccc(CCNC(=O)CSc2nc3ccccc3nc2N4CCCC4)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I15 compound treatment 101600.0 30700.0 0.51 151880.0 29900.0 0.48 0.6954 0.9995 3026945 ChemDiv3_007231 NS(=O)(=O)c1ccc(NC(=O)CCC2COc3ccccc3O2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I16 compound treatment 139400.0 68500.0 1.13 170880.0 48900.0 0.78 1.3507 0.9834 1398603 ChemDiv3_007232 Nc1nonc1N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I17 compound treatment 62520.0 -8340.0 -0.14 68720.0 -53300.0 -0.85 -0.698 -0.8112 3118745 ChemDiv3_007233 COc1ccc(OC)c(NC(=O)c2ccc(CSc3ncnc4[nH]cnc34)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I18 compound treatment 131840.0 61000.0 1.01 158880.0 36900.0 0.59 1.1272 0.9672 3026838 ChemDiv3_007234 CC1CC(=O)c2cnc(nc2C1)N3CCc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I19 compound treatment 36200.0 -34700.0 -0.57 34480.0 -87500.0 -1.4 -1.3911 -0.9225 3118881 ChemDiv3_007235 COC(=O)c1ccc(CSc2nc(cc(n2)C(F)(F)F)c3cccs3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I20 compound treatment 115880.0 45000.0 0.74 144880.0 22900.0 0.36 0.7832 0.9462 3026840 ChemDiv3_007236 NC1=C(C#N)C(N=C2SCCN21)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I21 compound treatment 55520.0 -15300.0 -0.25 22640.0 -99400.0 -1.58 -1.2991 -0.8099 3118882 ChemDiv3_007237 CCc1cc(C(N2CCN(CCO)CC2)c3ccc(Cl)cc3)c(NC(=O)c4ccccc4)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I22 compound treatment 84600.0 13700.0 0.23 127160.0 5150.0 0.08 0.2183 0.9055 3026842 ChemDiv3_007238 CCCCN1C(=NC(C2=C1CC(C)(C)CC2=O)(C(F)(F)F)C(F)(F)F)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I23 mock treatment 91680.0 20800.0 0.34 153040.0 31000.0 0.49 0.5926 0.9842 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 I24 mock treatment 42280.0 -28600.0 -0.47 88640.0 -33400.0 -0.53 -0.7098 -0.9982 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J01 compound treatment 5600.0 -65300.0 -1.08 13960.0 -108000.0 -1.72 -1.9796 -0.9745 3026843 ChemDiv3_007239 Oc1ccc(CNc2cccc(c2)C(F)(F)F)c3cccnc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J02 compound treatment 14280.0 -56600.0 -0.93 18000.0 -104000.0 -1.66 -1.8327 -0.9632 3118883 ChemDiv3_007240 Oc1ccc(Cl)cc1/C=N/c2ccc3nc(SCC=C)sc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J03 compound treatment 4800.0 -66100.0 -1.09 8560.0 -113000.0 -1.81 -2.0498 -0.9707 1273454 ChemDiv3_007241 COc1ccc(cc1)C(N2CCOCC2)c3ccc4cccnc4c3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J04 compound treatment 69840.0 -1020.0 -0.02 133760.0 11700.0 0.19 0.1204 0.6407 3026846 ChemDiv3_007242 O=C1CCCC(=O)C1=CNc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J05 compound treatment 81480.0 10600.0 0.18 110600.0 -11400.0 -0.18 -0.0047 -0.0187 3118884 ChemDiv3_007243 Cc1cccc(C)c1OCc2nnc(CCc3ccccc3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J06 compound treatment 68680.0 -2180.0 -0.04 80320.0 -41700.0 -0.66 -0.4954 -0.7444 1651075 ChemDiv3_007244 O=C1N(N=C2CCCCCC2)C(Nc3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J07 compound treatment 7280.0 -63600.0 -1.05 9600.0 -112000.0 -1.79 -2.0091 -0.9675 3118885 ChemDiv3_007245 FC(F)(F)c1c(C#N)c(SCc2ccccc2Cl)nc3-c4ccoc4CCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J08 compound treatment 122240.0 51400.0 0.85 185520.0 63500.0 1.01 1.3154 0.9961 1275637 ChemDiv3_007246 Fc1ccccc1C(=O)NCC(=O)NCc2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J09 compound treatment 46120.0 -24700.0 -0.41 58360.0 -63700.0 -1.01 -1.0062 -0.92 3026850 ChemDiv3_007247 CC12CNC3(CO)CC2CCC13C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J10 compound treatment 119880.0 49000.0 0.81 154160.0 32100.0 0.51 0.9344 0.9757 3118886 ChemDiv3_007248 O=C(CSc1nnc(c2cccnc2)n1c3ccccc3)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J11 compound treatment 82960.0 12100.0 0.2 98040.0 -24000.0 -0.38 -0.129 -0.2992 3026852 ChemDiv3_007249 CCOC(=O)c1ccc2nc(nc(N3CCCCC3)c2c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J12 compound treatment 122360.0 51500.0 0.85 113800.0 -8210.0 -0.13 0.5085 0.5912 1632505 ChemDiv3_007250 COc1ccc(NC(=O)c2ccc3c(=O)n(Cc4ccco4)c(=S)[nH]c3c2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J13 compound treatment 128800.0 57900.0 0.96 150920.0 28900.0 0.46 1.002 0.9439 3118887 ChemDiv3_007251 Cc1cc2OC(=C(C#N)C(c3cccs3)c2c(=O)n1CC4CCCO4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J14 compound treatment 130680.0 59800.0 0.99 175560.0 53500.0 0.85 1.3017 0.9974 1147245 ChemDiv3_007252 COc1ccc(OC)c(c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)N4CCC(CC4)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J15 compound treatment 79000.0 8140.0 0.13 120160.0 -1850.0 -0.03 0.0741 0.5387 3026904 ChemDiv3_007253 Oc1ccc(Nc2nc(N3CCOCC3)c4ccccc4n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J16 compound treatment 18240.0 -52600.0 -0.87 45800.0 -76200.0 -1.21 -1.4732 -0.9865 3118888 ChemDiv3_007254 Fc1ccc(cc1)N2CCN(CC2)C(=O)CCNC(=O)Cn3cnc4sc5CCCCc5c4c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J17 compound treatment 116560.0 45700.0 0.75 172920.0 50900.0 0.81 1.1071 0.9993 3026906 ChemDiv3_007255 COC(=O)c1ccc(OP2(=O)COc3ccccc3OC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J18 compound treatment 22880.0 -48000.0 -0.79 16960.0 -105000.0 -1.67 -1.7441 -0.9416 3026908 ChemDiv3_007256 CCOC(=O)c1cnc2cc(ccc2c1N3CCCCCC3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J19 compound treatment 138000.0 67100.0 1.11 158880.0 36900.0 0.59 1.1991 0.956 3118889 ChemDiv3_007257 Oc1cccc(NC=C2C(=O)NC(=S)NC2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J20 compound treatment 122600.0 51700.0 0.85 165520.0 43500.0 0.69 1.0942 0.9947 1384020 ChemDiv3_007258 O=C(N(C1CCCCC1)c2ccccc2)c3cnc4SCCn4c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J21 compound treatment 105200.0 34300.0 0.57 148960.0 26900.0 0.43 0.7045 0.9906 3026911 ChemDiv3_007259 CSc1nc(=O)c(Cc2ccccc2)n[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J22 compound treatment 16880.0 -54000.0 -0.89 22240.0 -99800.0 -1.59 -1.7546 -0.9625 1518725 ChemDiv3_007260 COc1ccc(cc1)C(=O)NCCn2cc(SC(C)c3ccccc3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J23 mock treatment 71600.0 736.0 0.01 146360.0 24300.0 0.39 0.283 0.7289 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 J24 mock treatment 73040.0 2180.0 0.04 104400.0 -17600.0 -0.28 -0.1731 -0.6116 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K01 compound treatment 27720.0 -43100.0 -0.71 148400.0 26400.0 0.42 -0.2062 -0.2493 1788828 ChemDiv3_007261 O=C(N1CCc2ccccc2C1)c3nc4ncccn4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K02 compound treatment 41160.0 -29700.0 -0.49 102320.0 -19700.0 -0.31 -0.5687 -0.9768 3118890 ChemDiv3_007262 CC(=O)Oc1cc2c(C(=O)N3CCCC3)c(C)oc2c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K03 compound treatment 76760.0 5900.0 0.1 137920.0 15900.0 0.25 0.2481 0.9136 3026914 ChemDiv3_007263 CCOC(=O)c1cnn2c(cc(C)nc12)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K04 compound treatment 105840.0 35000.0 0.58 149840.0 27800.0 0.44 0.7219 0.9915 3118891 ChemDiv3_007264 Nc1ccc2[nH]c(CCC(=O)O)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K05 compound treatment 36320.0 -34500.0 -0.57 47320.0 -74700.0 -1.19 -1.245 -0.9432 1026774 ChemDiv3_007265 COc1ccc(cc1)[n+]2cc(O)on2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K06 compound treatment 30040.0 -40800.0 -0.67 46360.0 -75700.0 -1.21 -1.3291 -0.9622 3118892 ChemDiv3_007266 Cc1cc2C(=O)C(=C(C(=O)c2cc1C)c3ccccc3)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K07 compound treatment 7200.0 -63700.0 -1.05 10200.0 -112000.0 -1.78 -2.0033 -0.9683 3026917 ChemDiv3_007267 CCc1cccc2c(c[nH]c12)C(C(=O)c3ccccc3)c4c[nH]c5c(CC)cccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K08 compound treatment 64520.0 -6340.0 -0.1 155720.0 33700.0 0.54 0.3058 0.5588 3118893 ChemDiv3_007268 OCC1CCCN1CC2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K09 compound treatment 86920.0 16100.0 0.27 187880.0 65900.0 1.05 0.9297 0.8587 3118894 ChemDiv3_007269 CC(C)CNC(=O)C1Sc2nnc(c3ccccc3)n2NC1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K10 compound treatment 122360.0 51500.0 0.85 167840.0 45800.0 0.73 1.1176 0.9971 3026967 ChemDiv3_007270 Cn1c(=O)n(C)c2nc(ncc2c1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K11 compound treatment 70040.0 -824.0 -0.01 104960.0 -17100.0 -0.27 -0.2018 -0.7416 1131768 ChemDiv3_007271 CC(=O)Nc1ccc(Nc2c3-c4ccccc4C(=O)c5cccc([nH]c2=O)c53)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K12 compound treatment 10360.0 -60500.0 -1.0 14680.0 -107000.0 -1.71 -1.9159 -0.9672 3026969 ChemDiv3_007272 CCOC(=O)C1=C(CSc2ccc(Cl)cc2)NC(=O)NC1c3cc(C)ccc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K13 compound treatment 144920.0 74100.0 1.22 183320.0 61300.0 0.98 1.5553 0.9938 3118895 ChemDiv3_007273 O=C1/C(=C/Nc2ccccc2c3nc4ccccc4c(=O)o3)/Sc5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K14 compound treatment 91000.0 20100.0 0.33 140320.0 18300.0 0.29 0.4414 0.9979 3026972 ChemDiv3_007274 O=C(CSc1nc2ccccc2nc1N3CCCC3)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K15 compound treatment 115080.0 44200.0 0.73 187200.0 65200.0 1.04 1.2508 0.9851 3118896 ChemDiv3_007275 NS(=O)(=O)c1ccc(CCNC(=O)CCC2COc3ccccc3O2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K16 compound treatment 7440.0 -63400.0 -1.05 13480.0 -109000.0 -1.73 -1.9635 -0.9711 3118897 ChemDiv3_007276 CCN(CC)CCn1c(=N)n(Cc2ccc(cc2)C(C)(C)C)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K17 compound treatment 94000.0 23100.0 0.38 141120.0 19100.0 0.3 0.4854 0.9937 1582818 ChemDiv3_007277 CCC(=O)Nc1nonc1c2nc3ccccc3n2CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K18 compound treatment 113000.0 42100.0 0.7 181040.0 59000.0 0.94 1.1571 0.989 3118898 ChemDiv3_007278 Cc1ccc(cc1)S(=O)(=O)NC2=NCN(CCN3CCOCC3)CN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K19 compound treatment 99440.0 28600.0 0.47 178880.0 56900.0 0.91 0.9744 0.9537 3026975 ChemDiv3_007279 Cc1ccc(o1)C(O)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K20 compound treatment 112440.0 41600.0 0.69 185680.0 63700.0 1.01 1.2028 0.9819 3118899 ChemDiv3_007280 Cc1ccc(cc1)C2=NC(N=C3SCCN32)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K21 compound treatment 55880.0 -15000.0 -0.25 92640.0 -29400.0 -0.47 -0.5059 -0.9555 3026978 ChemDiv3_007281 CCOC(=O)C1CCN(CC1)C(c2c(NC(=O)C)sc3CCCCc23)c4cccc(Cl)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K22 compound treatment 52520.0 -18300.0 -0.3 132600.0 10600.0 0.17 -0.0948 -0.2735 3118900 ChemDiv3_007282 CCCCN1C(=O)NC(C2=C1CC(C)(C)CC2=O)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K23 mock treatment 97440.0 26600.0 0.44 122840.0 826.0 0.01 0.3195 0.728 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 K24 mock treatment 26800.0 -44100.0 -0.73 132560.0 10500.0 0.17 -0.3955 -0.5297 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L01 compound treatment 2200.0 -68700.0 -1.13 7640.0 -114000.0 -1.82 -2.0905 -0.9739 1446827 ChemDiv3_007283 COc1ccc(cc1)C(N2CCOCC2)c3c(C)[nH]c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L02 compound treatment 33720.0 -37100.0 -0.61 110640.0 -11400.0 -0.18 -0.5617 -0.8786 3026980 ChemDiv3_007284 COc1ccc(/C=N/N2C(=O)c3ccc4CCc5ccc(C2=O)c3c45)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L03 compound treatment 4120.0 -66700.0 -1.1 16840.0 -105000.0 -1.68 -1.9644 -0.9793 3119027 ChemDiv3_007285 CC(=O)Nc1cccc(c1)C2=Nc3ccccc3SC(C2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L04 compound treatment 57280.0 -13600.0 -0.22 147920.0 25900.0 0.41 0.1334 0.2839 1408100 ChemDiv3_007286 Clc1ccc(cc1)C(=O)c2ccc(cc2)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L05 compound treatment 88840.0 18000.0 0.3 167920.0 45900.0 0.73 0.7272 0.921 3027023 ChemDiv3_007287 COC(=O)CC1N(CCNC1=O)C(=O)OC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L06 compound treatment 131200.0 60300.0 1.0 148680.0 26700.0 0.43 1.0048 0.9279 3119028 ChemDiv3_007288 COc1ccc(cc1)/C(=N/N2C(Nc3ccccc3C2=O)c4ccccc4O)/C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L07 compound treatment 41160.0 -29700.0 -0.49 90680.0 -31300.0 -0.5 -0.6999 -1.0 3119029 ChemDiv3_007289 COC(=O)c1ccccc1NC(=O)c2ccc(cc2)n3nc(c4CCc5occc5-c43)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L08 compound treatment 45080.0 -25800.0 -0.43 139120.0 17100.0 0.27 -0.1082 -0.214 3027025 ChemDiv3_007290 Cc1cc2nc3s/c(=C/4\C(=O)N(CC(=O)O)c5ccccc45)/c(=O)n3c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L09 compound treatment 41800.0 -29100.0 -0.48 101680.0 -20300.0 -0.32 -0.5684 -0.9818 3119030 ChemDiv3_007291 Cc1ccc(NC(=O)c2ccc(cc2)n3nc(c4CCc5occc5-c43)C(F)(F)F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L10 compound treatment 113160.0 42300.0 0.7 187560.0 65500.0 1.04 1.2324 0.9808 3027027 ChemDiv3_007292 COC(=O)Nc1ccc(cc1)C(=O)NCC2CCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L11 compound treatment 74640.0 3780.0 0.06 125520.0 3510.0 0.06 0.0836 0.9985 3119031 ChemDiv3_007293 CCOC(=O)c1ccc2nc(nc(NCc3ccc(Cl)cc3)c2c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L12 compound treatment 138040.0 67200.0 1.11 176200.0 54200.0 0.86 1.3948 0.9924 1631642 ChemDiv3_007294 CCOC(=O)N1CCN(CC1)C(=O)c2ccc3c(=O)n(CC4CCCO4)c(=S)[nH]c3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L13 compound treatment 141320.0 70500.0 1.16 171040.0 49000.0 0.78 1.3749 0.9813 3119032 ChemDiv3_007295 Cc1cc(O)cc(=O)n1Cc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L14 compound treatment 123640.0 52800.0 0.87 174920.0 52900.0 0.84 1.2123 0.9999 1665168 ChemDiv3_007296 COc1ccc(c(OC)c1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)NC4CCCC(C)C4C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L15 compound treatment 28360.0 -42500.0 -0.7 63480.0 -58500.0 -0.93 -1.1558 -0.9901 3027031 ChemDiv3_007297 C1CCN(CC1)c2ncnc3c4ccccc4oc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L16 compound treatment 67000.0 -3860.0 -0.06 178560.0 56500.0 0.9 0.5922 0.6554 1122672 ChemDiv3_007298 COc1ccc(cc1)C2C3=C(CC(C)(C)CC3=O)N(C)C4=C2C(=O)CC(C)(C)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L17 compound treatment 65920.0 -4940.0 -0.08 157920.0 35900.0 0.57 0.347 0.6002 3027033 ChemDiv3_007299 Clc1ccc2nc(NP3(=O)COc4ccccc4O3)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L18 compound treatment 9360.0 -61500.0 -1.02 23000.0 -99000.0 -1.58 -1.8338 -0.9772 3119033 ChemDiv3_007300 CCOC(=O)c1cnc2cc(ccc2c1N3CC(C)CC(C)C3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L19 compound treatment 97920.0 27100.0 0.45 154120.0 32100.0 0.51 0.6777 0.9977 3027035 ChemDiv3_007301 CCC1(CC)C(=O)N(CC(=O)OC)C(=O)N(C)C1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L20 compound treatment 80920.0 10100.0 0.17 162200.0 40200.0 0.64 0.5703 0.8619 1630796 ChemDiv3_007302 COc1cccc2sc(NC(=O)c3ccc(cc3)S(=O)(=O)N(C)C)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L21 compound treatment 101800.0 30900.0 0.51 151200.0 29200.0 0.47 0.69 0.9989 3119034 ChemDiv3_007303 COC(=O)c1ccc(/C=N/c2ccc3oc(nc3c2)c4ccc(C)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L22 compound treatment 43480.0 -27400.0 -0.45 78960.0 -43100.0 -0.69 -0.8049 -0.9795 1710843 ChemDiv3_007304 COc1ccc(cc1)C(=O)NCCn2cc(SCC(=O)Nc3ccccc3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L23 mock treatment 39880.0 -31000.0 -0.51 141440.0 19400.0 0.31 -0.1427 -0.2387 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 L24 mock treatment 28600.0 -42300.0 -0.7 131320.0 9310.0 0.15 -0.3884 -0.5446 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M01 compound treatment 29680.0 -41200.0 -0.68 143040.0 21000.0 0.34 -0.2437 -0.3216 1183622 ChemDiv3_007305 O=C(NCc1ccccc1)c2nc3ncccn3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M02 compound treatment 20520.0 -50300.0 -0.83 58920.0 -63100.0 -1.01 -1.2987 -0.9955 3119035 ChemDiv3_007306 COc1ccc(CNC(=O)c2c(C)oc3c2cc(OC(=O)C)c4ccccc34)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M03 compound treatment 33000.0 -37900.0 -0.63 128680.0 6670.0 0.11 -0.3668 -0.5786 3027121 ChemDiv3_007307 COc1cccc(c1)C2CC(n3ncc(C(=O)O)c3N2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M04 compound treatment 64680.0 -6180.0 -0.1 140560.0 18500.0 0.3 0.1368 0.4376 3119036 ChemDiv3_007308 Cc1ccc2[nH]c(CCCC(=O)O)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M05 compound treatment 54760.0 -16100.0 -0.27 137840.0 15800.0 0.25 -0.0096 -0.0262 3027123 ChemDiv3_007309 CCSC1=C(C#N)C(=O)NC(S1)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M06 compound treatment 83680.0 12800.0 0.21 167600.0 45600.0 0.73 0.6634 0.8766 3119037 ChemDiv3_007310 O=C(Nc1ccccc1)C2CC(=O)n3ncnc3N2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M07 compound treatment 55400.0 -15500.0 -0.26 151520.0 29500.0 0.47 0.152 0.2841 1057220 ChemDiv3_007311 OC(COc1ccccc1)Cn2ccccc2=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M08 compound treatment 44760.0 -26100.0 -0.43 179920.0 57900.0 0.92 0.3479 0.3416 3027125 ChemDiv3_007312 CC(=O)Nc1cccc(c1)c2nn3c(C)nnc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M09 compound treatment 65480.0 -5380.0 -0.09 194720.0 72700.0 1.16 0.7566 0.651 3119038 ChemDiv3_007313 Fc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)NCc4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M10 compound treatment 81160.0 10300.0 0.17 193200.0 71200.0 1.13 0.9225 0.8041 3027127 ChemDiv3_007314 COC(=O)c1c(C)ncc2COC(C)OCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M11 compound treatment 7800.0 -63100.0 -1.04 15160.0 -107000.0 -1.7 -1.9404 -0.9721 3119039 ChemDiv3_007315 Oc1c(Sc2cccc3cccnc23)cc(NS(=O)(=O)c4ccc(Cl)cc4)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M12 compound treatment 135440.0 64600.0 1.07 181640.0 59600.0 0.95 1.4258 0.9984 3027129 ChemDiv3_007316 O=C(CSc1ccccn1)N2CCN(C2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M13 compound treatment 123520.0 52700.0 0.87 165840.0 43800.0 0.7 1.1086 0.9941 3119040 ChemDiv3_007317 CN(C)CCNC(=O)c1cc2ccccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M14 compound treatment 67800.0 -3060.0 -0.05 133120.0 11100.0 0.18 0.0894 0.4857 3119041 ChemDiv3_007318 CC1CN(CC(C)O1)c2nc3ccccc3nc2SCC(=O)NCCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M15 compound treatment 101600.0 30700.0 0.51 169280.0 47300.0 0.75 0.8915 0.9815 3027131 ChemDiv3_007319 COCCn1c(nc(=S)c2COC(C)(C)Cc21)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M16 compound treatment 40040.0 -30800.0 -0.51 77800.0 -44200.0 -0.7 -0.8581 -0.9872 3027133 ChemDiv3_007320 Cn1c(=N)n(CCCOc2ccc(F)cc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M17 compound treatment 58800.0 -12100.0 -0.2 105800.0 -16200.0 -0.26 -0.3235 -0.9917 3119042 ChemDiv3_007321 Cc1ccn2cc(cc2c1)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M18 compound treatment 91320.0 20500.0 0.34 156320.0 34300.0 0.55 0.6254 0.9732 3119043 ChemDiv3_007322 Cc1ccc2C(=O)NC(Nc2c1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M19 compound treatment 54880.0 -16000.0 -0.26 125320.0 3310.0 0.05 -0.1493 -0.5549 3027207 ChemDiv3_007323 CCOC(=O)c1ccc(Nc2nnc3n(CC=C)c(=O)c4c(C)c(C)sc4n23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M20 compound treatment 57480.0 -13400.0 -0.22 136760.0 14700.0 0.24 0.01 0.0309 3119044 ChemDiv3_007324 CC1=C(C#N)C(N=C(N1)c2ccncc2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M21 compound treatment 6280.0 -64600.0 -1.07 11960.0 -110000.0 -1.75 -1.9942 -0.9715 3027209 ChemDiv3_007325 CC1CCN(CC1)C(=O)c2c(C)oc3C(=O)c4ccccc4C(=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M22 compound treatment 35760.0 -35100.0 -0.58 112760.0 -9250.0 -0.15 -0.514 -0.8597 3119045 ChemDiv3_007326 CC1=C(C#N)C(N=C(Cc2ccccc2)N1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M23 mock treatment 51280.0 -19600.0 -0.32 151880.0 29900.0 0.48 0.108 0.1877 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 M24 mock treatment 38840.0 -32000.0 -0.53 129080.0 7070.0 0.11 -0.2942 -0.5442 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N01 compound treatment 36480.0 -34400.0 -0.57 75040.0 -47000.0 -0.75 -0.9307 -0.9907 1651520 ChemDiv3_007327 COc1ccc(cc1)C(OC(=O)c2ccccc2)c3nccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N02 compound treatment 35160.0 -35700.0 -0.59 181080.0 59100.0 0.94 0.2489 0.2241 1505116 ChemDiv3_007328 Cc1ccc(NC(=O)c2cc(=O)[nH]c(=O)[nH]2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N03 compound treatment 45280.0 -25600.0 -0.42 146880.0 24900.0 0.4 -0.0184 -0.0317 3119046 ChemDiv3_007329 CC(=O)N1CN(Cc2c3CCCCc3sc12)C4CCS(=O)(=O)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N04 compound treatment 31440.0 -39400.0 -0.65 151200.0 29200.0 0.47 -0.1312 -0.1641 1135097 ChemDiv3_007330 CCN(CC)S(=O)(=O)c1ccc(Cl)c(c1)C(=O)Oc2ccc(C)c(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N05 compound treatment 9720.0 -61100.0 -1.01 22600.0 -99400.0 -1.58 -1.8341 -0.9763 3119047 ChemDiv3_007331 Oc1ccc(NC(=O)CN2CC(=O)Oc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N06 compound treatment 56360.0 -14500.0 -0.24 173680.0 51700.0 0.82 0.413 0.4816 3027214 ChemDiv3_007332 CCOC(=O)C1=C(NC(=S)NC1CC)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N07 compound treatment 29680.0 -41200.0 -0.68 78880.0 -43100.0 -0.69 -0.9668 -1.0 3119048 ChemDiv3_007333 CC(C)(C)NC(=O)c1ccc(cc1)n2nc(c3CCc4occc4-c32)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N08 compound treatment 75760.0 4900.0 0.08 198200.0 76200.0 1.21 0.9158 0.7525 3119179 ChemDiv3_007334 CCc1nnc(NC(=O)CSc2nc(cc(c2C#N)C(F)(F)F)c3ccccc3)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N09 compound treatment 53680.0 -17200.0 -0.28 189840.0 67800.0 1.08 0.5638 0.5045 3027218 ChemDiv3_007335 OC(=O)c1nn(c-2c1CCc3occc32)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N10 compound treatment 53280.0 -17600.0 -0.29 88000.0 -34000.0 -0.54 -0.5886 -0.9571 3119180 ChemDiv3_007336 COc1ccc(NC(=C2C(=O)CC(C)(C)CC2=O)CCCN3C(=O)c4ccccc4C3=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N11 compound treatment 38000.0 -32900.0 -0.54 67640.0 -54400.0 -0.87 -0.9964 -0.9745 3027294 ChemDiv3_007337 CCOC(=O)c1ccc2nc(nc(NCCc3ccc(OC)cc3)c2c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N12 compound treatment 108640.0 37800.0 0.62 196920.0 74900.0 1.19 1.2851 0.9541 1740813 ChemDiv3_007338 COc1ccc(cc1)n2c(=O)c3ccc(cc3[nH]c2=S)C(=O)N4CCN(CC4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N13 compound treatment 113400.0 42500.0 0.7 154480.0 32500.0 0.52 0.8624 0.9887 3027297 ChemDiv3_007339 COc1ccc(Cn2c(C)cc(O)cc2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N14 compound treatment 14360.0 -56500.0 -0.93 18640.0 -103000.0 -1.65 -1.8246 -0.9637 1296230 ChemDiv3_007340 Cc1ccc(NC(=O)c2ccc3c(=O)n(Cc4ccco4)c(=S)[nH]c3c2)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N15 compound treatment 37960.0 -32900.0 -0.54 153320.0 31300.0 0.5 -0.0312 -0.0424 3027299 ChemDiv3_007341 OCn1c2CCCCc2c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N16 compound treatment 22440.0 -48400.0 -0.8 90600.0 -31400.0 -0.5 -0.9193 -0.9746 3119181 ChemDiv3_007342 Cc1ccc(cc1C)N2C3=C(C(C4=C2CC(C)(C)CC4=O)c5cccs5)C(=O)CC(C)(C)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N17 compound treatment 46640.0 -24200.0 -0.4 183600.0 61600.0 0.98 0.4113 0.3881 3027303 ChemDiv3_007343 Brc1ccc(cc1)C(=O)C(C(=O)N2CCCCC2)n3ccccc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N18 compound treatment 4720.0 -66100.0 -1.09 14320.0 -108000.0 -1.72 -1.9858 -0.9761 3119182 ChemDiv3_007344 CCOC(=O)c1cnc2c(OC)cccc2c1NC3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N19 compound treatment 68320.0 -2540.0 -0.04 166160.0 44100.0 0.7 0.4678 0.6637 3027305 ChemDiv3_007345 CCOc1ccc(/C=N/n2c(C)nc3ccccc3c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N20 compound treatment 25560.0 -45300.0 -0.75 75600.0 -46400.0 -0.74 -1.0519 -1.0 1741518 ChemDiv3_007346 COc1cccc2sc(NC(=O)c3ccc(cc3)S(=O)(=O)N4CCCC(C)C4)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N21 compound treatment 39480.0 -31400.0 -0.52 136480.0 14500.0 0.23 -0.2033 -0.3585 3027307 ChemDiv3_007347 COc1cc(/C=N/c2ccc(C)cc2)ccc1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N22 compound treatment 26320.0 -44500.0 -0.74 122560.0 546.0 0.01 -0.5138 -0.6987 1286138 ChemDiv3_007348 COc1ccc(cc1)C(=O)NCCn2cc(SCC(=O)N3CCCCC3)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N23 mock treatment 47200.0 -23700.0 -0.39 149560.0 27500.0 0.44 0.0342 0.0583 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 N24 mock treatment 41760.0 -29100.0 -0.48 120880.0 -1130.0 -0.02 -0.3525 -0.7332 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O01 compound treatment 38960.0 -31900.0 -0.53 89200.0 -32800.0 -0.52 -0.7422 -1.0 1788832 ChemDiv3_007349 O=C(N(Cc1ccccc1)Cc2ccccc2)c3nc4ncccn4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O02 compound treatment 28640.0 -42200.0 -0.7 95760.0 -26300.0 -0.42 -0.7887 -0.9702 3119183 ChemDiv3_007350 COc1ccc(cc1)N(C(=O)c2ccccc2)S(=O)(=O)c3cccc4cccnc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O03 compound treatment 13960.0 -56900.0 -0.94 82360.0 -39700.0 -0.63 -1.1111 -0.9814 3027446 ChemDiv3_007351 COc1ccc2nc3C(=O)c4ccccc4C(=O)c3nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O04 compound treatment 45200.0 -25700.0 -0.42 151240.0 29200.0 0.47 0.0298 0.0474 3119184 ChemDiv3_007352 OC(=O)c1ccc2[nH]c(CCc3nc4cc(ccc4[nH]3)C(=O)O)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O05 compound treatment 30880.0 -40000.0 -0.66 167520.0 45500.0 0.73 0.0462 0.0471 3027447 ChemDiv3_007353 CCSC1=C(C#N)C(=O)NCS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O06 compound treatment 2640.0 -68200.0 -1.13 9800.0 -112000.0 -1.79 -2.061 -0.9751 3119185 ChemDiv3_007354 Clc1ccccc1C2N=C(Nc3nc4ccccc4s3)NC5=C2C(=O)CCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O07 compound treatment 15000.0 -55900.0 -0.92 88560.0 -33500.0 -0.53 -1.0291 -0.9661 3027478 ChemDiv3_007355 COc1ccc(cc1)C2=Cc3ccccc3C(C)(C)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O08 compound treatment 31000.0 -39900.0 -0.66 161880.0 39900.0 0.64 -0.016 -0.0175 3119186 ChemDiv3_007356 CC1(C)CC(=O)C2=C(C1)NCN(Cc3ccc4OCOc4c3)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O09 compound treatment 9000.0 -61900.0 -1.02 100160.0 -21900.0 -0.35 -0.9684 -0.8975 3119187 ChemDiv3_007357 Fc1ccc(cc1)C2Nn3c(nnc3SC2C(=O)Nc4ccccc4C(F)(F)F)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O10 compound treatment 49440.0 -21400.0 -0.35 154880.0 32900.0 0.52 0.1203 0.1904 3027482 ChemDiv3_007358 CCCC[N+]1(C)C2CCC1CC(O)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O11 compound treatment 98560.0 27700.0 0.46 156480.0 34500.0 0.55 0.7117 0.9958 3027483 ChemDiv3_007359 OCCNS(=O)(=O)c1cccc2cccnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O12 compound treatment 72760.0 1900.0 0.03 98040.0 -24000.0 -0.38 -0.2481 -0.647 3119188 ChemDiv3_007360 Cc1ccc2oc(c(CN3CCOCC3)c(=O)c2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O13 compound treatment 126040.0 55200.0 0.91 182480.0 60500.0 0.96 1.3255 0.9996 3027487 ChemDiv3_007361 CCCN1CC2CCCC3(C1)C(=O)NC4(CCCCC4)N=C23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O14 compound treatment 69080.0 -1780.0 -0.03 159160.0 37100.0 0.59 0.3978 0.6711 3119189 ChemDiv3_007362 CC1CN(CC(C)O1)c2nc3ccccc3nc2SCC(=O)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O15 compound treatment 46720.0 -24100.0 -0.4 110280.0 -11700.0 -0.19 -0.4141 -0.9405 3119190 ChemDiv3_007363 Sc1ncnc2c1sc3nc(N4CCOCC4)c5CCCCc5c32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O16 compound treatment 3600.0 -67300.0 -1.11 12840.0 -109000.0 -1.74 -2.0155 -0.9765 3027489 ChemDiv3_007364 CCn1c(=N)n(CCCOc2ccc(Br)cc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O17 compound treatment 33720.0 -37100.0 -0.61 178440.0 56400.0 0.9 0.2024 0.1859 3119191 ChemDiv3_007365 COc1cccc(CN2c3cccc4cccc(c34)S2(=O)=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O18 compound treatment 39520.0 -31300.0 -0.52 150960.0 28900.0 0.46 -0.0396 -0.0572 3027491 ChemDiv3_007366 CN(C)C1=NC(N=C(C)O1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O19 compound treatment 62880.0 -7980.0 -0.13 183960.0 61900.0 0.99 0.605 0.6073 3119192 ChemDiv3_007367 CN(CCO)C(=O)c1ccc-2c(c1)C(=O)c3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O20 compound treatment 46720.0 -24100.0 -0.4 140200.0 18200.0 0.29 -0.0769 -0.1559 3027493 ChemDiv3_007368 FC(F)(F)C1(C2CC(C=C2)N1C(=O)c3ccncc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O21 compound treatment 3280.0 -67600.0 -1.12 9360.0 -113000.0 -1.8 -2.0585 -0.9738 3119193 ChemDiv3_007369 Cc1oc2C(=O)c3ccccc3C(=O)c2c1C(=O)N4CCc5ccccc5C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O22 compound treatment 8240.0 -62600.0 -1.03 16440.0 -106000.0 -1.68 -1.9208 -0.9726 1582951 ChemDiv3_007370 CCN1CCN(CC1)C(c2cccnc2)c3ccc4cccnc4c3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O23 mock treatment 40080.0 -30800.0 -0.51 140480.0 18500.0 0.29 -0.1512 -0.2575 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 O24 mock treatment 59440.0 -11400.0 -0.19 135800.0 13800.0 0.22 0.022 0.0761 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P01 compound treatment 1440.0 -69400.0 -1.15 4440.0 -118000.0 -1.87 -2.1354 -0.9722 1619302 ChemDiv3_007371 Cc1[nH]c2ccccc2c1C(Nc3cc(C)ccn3)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P02 compound treatment 33200.0 -37700.0 -0.62 90640.0 -31400.0 -0.5 -0.7932 -0.9942 3119194 ChemDiv3_007372 Cc1ccc2NC(C3CC=CC3c2c1)c4ccc(/N=C/c5ccccc5)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P03 compound treatment 20800.0 -50100.0 -0.83 45520.0 -76500.0 -1.22 -1.4465 -0.9821 3027529 ChemDiv3_007373 CC(=O)N1CN(CCCn2ccnc2)Cc3c4CCCCc4sc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P04 compound treatment 6720.0 -64100.0 -1.06 49560.0 -72500.0 -1.15 -1.5653 -0.9991 3027531 ChemDiv3_007374 O=S(=O)(Nc1ccccc1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P05 compound treatment 17520.0 -53300.0 -0.88 38880.0 -83100.0 -1.33 -1.5596 -0.9803 3119195 ChemDiv3_007375 Fc1ccc(cc1)N2CCN(CC2)C(=O)CN3CC(=O)Oc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P06 compound treatment 2040.0 -68800.0 -1.14 6360.0 -116000.0 -1.84 -2.1068 -0.973 1922912 ChemDiv3_007376 OC(CC(=O)/C=C/c1ccccc1)(c2ccccc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P07 compound treatment 38200.0 -32700.0 -0.54 132040.0 10000.0 0.16 -0.2683 -0.477 3027533 ChemDiv3_007377 COC(=O)c1oc2CC(C)(C)c3nc4ccccc4nc3-c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P08 compound treatment 11280.0 -59600.0 -0.98 28360.0 -93700.0 -1.49 -1.751 -0.9795 1600357 ChemDiv3_007378 CCc1ccc(cc1)N2NC(=O)C(=C(C)C)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P09 compound treatment 20680.0 -50200.0 -0.83 54600.0 -67400.0 -1.07 -1.3455 -0.9917 3119196 ChemDiv3_007379 Cc1ccc(Sc2sc(=O)n(C)c2S(=O)(=O)c3ccc(C)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P10 compound treatment 13960.0 -56900.0 -0.94 39120.0 -82900.0 -1.32 -1.5984 -0.986 1389317 ChemDiv3_007380 S=C(NCCc1ccccc1)N2CCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P11 compound treatment 49880.0 -21000.0 -0.35 142400.0 20400.0 0.32 -0.0152 -0.0319 3119197 ChemDiv3_007381 Cc1cc2OC(=C(C#N)C(c3ccccc3)c2c(=O)n1Cc4ccccn4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P12 compound treatment 89560.0 18700.0 0.31 190120.0 68100.0 1.09 0.9858 0.8735 1520017 ChemDiv3_007382 O=C(NCC1CCCO1)c2ccc3c(=O)n(c4ccccc4)c(=S)[nH]c3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P13 compound treatment 49200.0 -21700.0 -0.36 119800.0 -2210.0 -0.04 -0.2778 -0.7731 3027536 ChemDiv3_007383 COc1ccc(CCn2c(C)cc(O)cc2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P14 compound treatment 39160.0 -31700.0 -0.52 135640.0 13600.0 0.22 -0.2165 -0.3821 1672880 ChemDiv3_007384 COc1ccc(CCNC(=O)c2ccc3c(=O)n(CC4CCCO4)c(=S)[nH]c3c2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P15 compound treatment 61000.0 -9860.0 -0.16 164480.0 42500.0 0.68 0.3635 0.5221 3027538 ChemDiv3_007385 O=C1CCC(=O)N1CCOP2(=O)COc3ccccc3OC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P16 compound treatment 35840.0 -35000.0 -0.58 138600.0 16600.0 0.26 -0.2219 -0.349 3119321 ChemDiv3_007386 CCN(CC)CCN1C2=C(C(C3=C1CC(C)(C)CC3=O)c4cccc(F)c4)C(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P17 compound treatment 54480.0 -16400.0 -0.27 162800.0 40800.0 0.65 0.2684 0.3813 3027592 ChemDiv3_007387 Oc1ccccc1CNCc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P18 compound treatment 25920.0 -44900.0 -0.74 140160.0 18100.0 0.29 -0.3201 -0.402 3119322 ChemDiv3_007388 CCOC(=O)c1cnc2c(OC)cccc2c1N3CCC4(CC3)OCCO4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P19 compound treatment 37280.0 -33600.0 -0.55 102480.0 -19500.0 -0.31 -0.6122 -0.9628 1582507 ChemDiv3_007389 CC(C)c1ccc(CNC(=O)CCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P20 compound treatment 41400.0 -29500.0 -0.49 128440.0 6430.0 0.1 -0.2715 -0.5462 3119323 ChemDiv3_007390 COC(=O)c1ccc2n(C)/c(=N\C(=O)c3ccc(cc3)S(=O)(=O)N4CCCCC4C)/sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P21 compound treatment 46720.0 -24100.0 -0.4 115640.0 -6370.0 -0.1 -0.3536 -0.8599 1257313 ChemDiv3_007391 O=C1N(CCSC(=S)N2CCSCC2)Cc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P22 compound treatment 37280.0 -33600.0 -0.55 92880.0 -29100.0 -0.46 -0.7203 -0.9961 1190401 ChemDiv3_007392 Cc1cccc(NC(=O)CSc2cn(CCNC(=O)c3ccc(F)cc3)c4ccccc24)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P23 mock treatment 60560.0 -10300.0 -0.17 103120.0 -18900.0 -0.3 -0.3332 -0.9634 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2021 P24 mock treatment 50720.0 -20100.0 -0.33 79560.0 -42500.0 -0.68 -0.7136 -0.9465 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A01 compound treatment 55440.0 -54600.0 -0.9 87080.0 -36200.0 -0.58 -1.0444 -0.9767 3063199 Maybridge4_000353 O=C1CCc2cc(ccc2N1)C3=CSC4=NCCN34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A02 compound treatment 6080.0 -104000.0 -1.72 5480.0 -118000.0 -1.88 -2.5402 -0.999 3178435 Maybridge4_000354 CC1(C)OC(=O)C(C2C3CC4CC(C3)CC2C4)C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A03 compound treatment 90880.0 -19100.0 -0.32 68240.0 -55000.0 -0.88 -0.843 -0.9049 3178436 Maybridge4_000355 Cc1nc(cs1)c2cc(C#N)c(SCCNC(=O)c3ccc(Cl)cc3Cl)nc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A04 compound treatment 34720.0 -75300.0 -1.24 25960.0 -97300.0 -1.55 -1.9751 -0.994 1602887 Maybridge4_000356 CC1(C)Oc2c(C=C1)c3c(=O)cc(oc3c4ccoc24)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A05 compound treatment 197600.0 87600.0 1.45 101120.0 -22100.0 -0.35 0.7732 0.5195 3063200 Maybridge4_000357 COc1cc(OC)nc(/N=C/N(C)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A06 compound treatment 120680.0 10700.0 0.18 63280.0 -60000.0 -0.96 -0.5511 -0.5671 3178437 Maybridge4_000358 CC1(C)CN=C(NC2CCCCC2)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A07 compound treatment 204160.0 94200.0 1.55 55080.0 -68200.0 -1.09 0.3309 0.1745 3178438 Maybridge4_000359 COc1ccc(CCC(=O)CCc2ccc(OC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A08 compound treatment 195920.0 85900.0 1.42 63560.0 -59700.0 -0.95 0.3303 0.1934 3063201 Maybridge4_000360 COc1ccccc1OC(=O)NC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A09 compound treatment 156280.0 46300.0 0.76 44800.0 -78400.0 -1.25 -0.3438 -0.2347 3178439 Maybridge4_000361 CCOC(=O)c1ccc(cc1)C(=S)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A10 compound treatment 69200.0 -40800.0 -0.67 19080.0 -104000.0 -1.66 -1.6501 -0.9211 1174208 Maybridge4_000362 CCC1(CCCCN(C)C1=O)c2cccc(OC(=O)C3CCCCC3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A11 compound treatment 219080.0 109000.0 1.8 91280.0 -32000.0 -0.51 0.913 0.4879 3063202 Maybridge4_000363 CN(C)Cc1c(C)cc(C)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A12 compound treatment 25560.0 -84400.0 -1.39 14800.0 -108000.0 -1.73 -2.2078 -0.9943 1469863 Maybridge4_000364 O=C(Nc1nc(cs1)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A13 compound treatment 225200.0 115000.0 1.9 116120.0 -7120.0 -0.11 1.2644 0.6637 1002608 Maybridge4_000365 CCOC(=O)c1cnc(S)nc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A14 compound treatment 203240.0 93200.0 1.54 123520.0 283.0 0.0 1.0915 0.7092 1583969 Maybridge4_000366 Clc1cccc(c1)C(=O)NC2CN3CCC2CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A15 compound treatment 53600.0 -56400.0 -0.93 23440.0 -99800.0 -1.59 -1.7831 -0.9675 3063203 Maybridge4_000367 COc1cc(C#N)c2ccc3ccccc3c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A16 compound treatment 214720.0 105000.0 1.73 84240.0 -39000.0 -0.62 0.7828 0.4261 3178440 Maybridge4_000368 CCNC(=Nc1ccc(Cl)cc1)NCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A17 compound treatment 209480.0 99500.0 1.64 89760.0 -33500.0 -0.53 0.7838 0.454 1368926 Maybridge4_000369 CC(=O)OCc1ccccc1Sc2ccccc2C(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A18 compound treatment 218000.0 108000.0 1.78 99760.0 -23500.0 -0.37 0.996 0.5468 1219932 Maybridge4_000370 C1C=C(Nc2nnnn12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A19 compound treatment 249880.0 140000.0 2.31 113200.0 -10000.0 -0.16 1.5196 0.6565 1528436 Maybridge4_000371 Cn1c(nc2ccccc12)N3C(=O)c4cccc5cccc(C3=O)c45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A20 compound treatment 133760.0 23800.0 0.39 87480.0 -35800.0 -0.57 -0.1257 -0.1817 1375750 Maybridge4_000372 CC1(CC2CC3(C)C1)CC(C2)(C3)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A21 compound treatment 83200.0 -26800.0 -0.44 43280.0 -80000.0 -1.27 -1.214 -0.8999 1405005 Maybridge4_000373 O=c1nc2sc3ccccc3n2c(=O)n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A22 compound treatment 133640.0 23600.0 0.39 119040.0 -4200.0 -0.07 0.2286 0.5774 3063251 Maybridge4_000374 C/S(=N\S(=O)(=O)c1ccc(Cl)cc1)/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A23 mock treatment 127560.0 17600.0 0.29 140920.0 17700.0 0.28 0.4042 0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 A24 mock treatment 57760.0 -52200.0 -0.86 129880.0 6640.0 0.11 -0.5349 -0.6157 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B01 compound treatment 133720.0 23700.0 0.39 123000.0 -238.0 0.0 0.2742 0.7002 3063252 Maybridge4_000375 C1CN(C1)C(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B02 compound treatment 60840.0 -49200.0 -0.81 24520.0 -98700.0 -1.57 -1.6864 -0.9526 3063253 Maybridge4_000376 CC1CCC(C)N1c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B03 compound treatment 182320.0 72300.0 1.19 119760.0 -3480.0 -0.06 0.8049 0.6736 3063254 Maybridge4_000377 Cc1ccc(cc1)S(=O)(=O)C[C@H]2O[C@H](C[C@@H]2O)n3cc(I)c(=O)[nH]c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B04 compound treatment 142000.0 32000.0 0.53 22760.0 -100000.0 -1.6 -0.7589 -0.45 3063255 Maybridge4_000378 C/C(=N\O)/c1cc(Cl)cc(Cl)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B05 compound treatment 92920.0 -17100.0 -0.28 70200.0 -53000.0 -0.85 -0.7971 -0.8945 3063256 Maybridge4_000379 CCN(CC)Cc1c(C)c(C)c(C)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B06 compound treatment 12520.0 -97500.0 -1.61 6880.0 -116000.0 -1.85 -2.4492 -0.9975 3178441 Maybridge4_000380 Oc1c(Cl)cc(Cl)cc1C2Nc3cc(ccc3-n4cccc24)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B07 compound treatment 155520.0 45500.0 0.75 89320.0 -33900.0 -0.54 0.149 0.161 1227211 Maybridge4_000381 CCC(C)(C)NC(=S)Nc1cccc(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B08 compound treatment 30520.0 -79500.0 -1.31 10840.0 -112000.0 -1.79 -2.1945 -0.9883 3178442 Maybridge4_000382 Cc1c(C)c(C)c2[nH]c(SCc3nc(no3)c4ccc(Cl)cc4)nc2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B09 compound treatment 13800.0 -96200.0 -1.59 6200.0 -117000.0 -1.87 -2.442 -0.9968 3063257 Maybridge4_000383 CSC1=C(C#N)C(=O)NC(S1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B10 compound treatment 184440.0 74400.0 1.23 111840.0 -11400.0 -0.18 0.7404 0.5961 3178443 Maybridge4_000384 C/C(=N\Cc1ccccc1)/c2c(C)cc(C)cc2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B11 compound treatment 97520.0 -12500.0 -0.21 36200.0 -87000.0 -1.39 -1.1266 -0.8033 1417340 Maybridge4_000385 COc1cc(cc(OC)c1OC)C2Nc3ccccc3S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B12 compound treatment 18240.0 -91800.0 -1.51 12120.0 -111000.0 -1.77 -2.3234 -0.997 1464378 Maybridge4_000386 N#CC1CN(CCc2ccccc2)CN(CCc3ccccc3)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B13 compound treatment 170920.0 60900.0 1.01 133800.0 10600.0 0.17 0.8301 0.8142 1213608 Maybridge4_000387 COc1cc(CO)c(CC(=O)NN)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B14 compound treatment 190400.0 80400.0 1.33 140560.0 17300.0 0.28 1.1337 0.8363 1103050 Maybridge4_000388 CC1(C)OC(=O)C(=Cc2ccc[nH]2)C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B15 compound treatment 19520.0 -90500.0 -1.49 8720.0 -115000.0 -1.83 -2.3468 -0.995 1559616 Maybridge4_000389 COc1cc(OC)cc(c1)c2nc(N)c3c(C)c(sc3n2)c4ccc(OC)c(OC)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B16 compound treatment 173040.0 63000.0 1.04 97280.0 -26000.0 -0.41 0.4433 0.3958 1513039 Maybridge4_000390 Cc1onc(c1NC(=O)N2CCCC2=O)c3c(Cl)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B17 compound treatment 178560.0 68600.0 1.13 101720.0 -21500.0 -0.34 0.5577 0.4716 1918178 Maybridge4_000391 Cc1ccc(NC(=O)C2C(C3CC2C=C3)C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B18 compound treatment 179440.0 69400.0 1.15 91200.0 -32000.0 -0.51 0.4494 0.3582 3178444 Maybridge4_000392 CS/C(=N\c1ccccc1C(F)(F)F)/N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B19 compound treatment 92440.0 -17600.0 -0.29 51800.0 -71400.0 -1.14 -1.0101 -0.8597 3178445 Maybridge4_000393 CCOC(=O)c1nc2ccccc2c(=O)n1/N=C/c3cc(Cl)cc(Cl)c3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B20 compound treatment 88920.0 -21100.0 -0.35 54560.0 -68700.0 -1.09 -1.0201 -0.8881 3063259 Maybridge4_000394 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B21 compound treatment 175760.0 65800.0 1.09 89200.0 -34000.0 -0.54 0.3839 0.3164 3063260 Maybridge4_000395 CSC(=NS(=O)(=O)c1ccccc1)SC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B22 compound treatment 39360.0 -70600.0 -1.17 14240.0 -109000.0 -1.74 -2.053 -0.9812 1232359 Maybridge4_000396 Cc1onc(c1C(=O)ON2C(=O)CCC2=O)c3c(Cl)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B23 mock treatment 163080.0 53100.0 0.88 113000.0 -10200.0 -0.16 0.5042 0.5657 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 B24 mock treatment 109040.0 -963.0 -0.02 124760.0 1520.0 0.02 0.0059 0.2042 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C01 compound treatment 141760.0 31800.0 0.52 102640.0 -20600.0 -0.33 0.1385 0.224 3063261 Maybridge4_000397 CN(C(=O)COc1cc(n(C)n1)C(F)(F)F)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C02 compound treatment 138960.0 29000.0 0.48 103800.0 -19400.0 -0.31 0.1189 0.2088 1015362 Maybridge4_000398 CCOC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C03 compound treatment 195720.0 85700.0 1.41 138440.0 15200.0 0.24 1.1719 0.8163 1410184 Maybridge4_000399 Cc1ccc(Oc2ncccc2NC(=O)c3ccc(Cl)cc3Cl)c4CCCc41 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C04 compound treatment 152160.0 42200.0 0.7 120440.0 -2800.0 -0.04 0.4605 0.6604 1430911 Maybridge4_000400 OC(=O)CCC(=O)c1ccc2OCCCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C05 compound treatment 144120.0 34100.0 0.56 119280.0 -3960.0 -0.06 0.3536 0.624 3063262 Maybridge4_000401 COc1cc(OC)nc(N/C=N/O)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C06 compound treatment 208880.0 98900.0 1.63 124040.0 803.0 0.01 1.1632 0.7126 1594886 Maybridge4_000402 Cn1c(=O)cc(Nc2ccccc2)c3c(=O)n(c4ccccc4)c(=O)n(c5ccccc5)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C07 compound treatment 155360.0 45400.0 0.75 97560.0 -25700.0 -0.41 0.24 0.2813 3063263 Maybridge4_000403 OC(=O)c1cc(=O)c2c(O)cccc2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C08 compound treatment 164480.0 54500.0 0.9 96960.0 -26300.0 -0.42 0.3397 0.3425 3063264 Maybridge4_000404 CC(C)NC(=O)Oc1cccc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C09 compound treatment 160400.0 50400.0 0.83 109080.0 -14200.0 -0.23 0.4287 0.4973 3178446 Maybridge4_000405 COC(=O)c1ccc(cc1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C10 compound treatment 154400.0 44400.0 0.73 85360.0 -37900.0 -0.6 0.0913 0.0962 1676301 Maybridge4_000406 COC(=O)C1C(NC(C(C(=O)OC)S1(=O)=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C11 compound treatment 161440.0 51400.0 0.85 151640.0 28400.0 0.45 0.9205 0.9566 3063265 Maybridge4_000407 O=C1CC(=NN1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C12 compound treatment 80480.0 -29500.0 -0.49 72200.0 -51000.0 -0.81 -0.9198 -0.97 1343081 Maybridge4_000408 CC(C1CC1)N(C(=O)c2cc(C)c(Cl)cc2Cl)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C13 compound treatment 28480.0 -81500.0 -1.35 26720.0 -96500.0 -1.54 -2.0393 -0.9978 1138226 Maybridge4_000409 COc1ccc2c(c1)nnc3n[nH]c(=O)n32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C14 compound treatment 161880.0 51900.0 0.86 134880.0 11600.0 0.19 0.7367 0.8408 1419670 Maybridge4_000410 OC(=O)CNC(=O)CSc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C15 compound treatment 155680.0 45700.0 0.75 91440.0 -31800.0 -0.51 0.1748 0.1924 3063266 Maybridge4_000411 CC1=C(C#N)C(C(=C(C)N1)C#N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C16 compound treatment 52520.0 -57500.0 -0.95 15240.0 -108000.0 -1.72 -1.8881 -0.9606 3178530 Maybridge4_000412 CCC1(CCCCN(C)C1=O)c2cccc(OC(=O)Nc3ccc(OC(F)(F)F)cc3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C17 compound treatment 133200.0 23200.0 0.38 75080.0 -48200.0 -0.77 -0.272 -0.3171 1346230 Maybridge4_000413 N#Cc1cccc2cccc(Sc3ccccc3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C18 compound treatment 147040.0 37000.0 0.61 120160.0 -3080.0 -0.05 0.3976 0.6483 1555561 Maybridge4_000414 COc1ccc(OC)c(CCCc2cc(OC)ccc2OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C19 compound treatment 168360.0 58400.0 0.96 119880.0 -3360.0 -0.05 0.6433 0.6668 3063267 Maybridge4_000415 CCN(CC)C(=O)Nc1ccc(OC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C20 compound treatment 92080.0 -17900.0 -0.3 57440.0 -65800.0 -1.05 -0.9508 -0.8725 1920088 Maybridge4_000416 S=c1nc(c2ccco2)n(Cc3ccccc3)c(=S)n1/C(=N/Cc4ccccc4)/c5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C21 compound treatment 170760.0 60800.0 1.0 136720.0 13500.0 0.21 0.8611 0.8396 3178531 Maybridge4_000417 FC(F)(F)c1cccc(c1)c2nc3ccccn3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C22 compound treatment 102720.0 -7280.0 -0.12 88840.0 -34400.0 -0.55 -0.4727 -0.8421 3178532 Maybridge4_000418 O=C(/C=C\1/NN=C(NC1=O)c2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C23 mock treatment 147400.0 37400.0 0.62 123360.0 123.0 0.0 0.4379 0.7093 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 C24 mock treatment 105320.0 -4680.0 -0.08 138120.0 14900.0 0.24 0.1131 0.4532 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D01 compound treatment 82120.0 -27900.0 -0.46 72480.0 -50800.0 -0.81 -0.8975 -0.9643 3178533 Maybridge4_000419 CC1(C)C2(C)CCC1(OC2=O)C(=O)N3NC(=O)[C@H]([C@@H]3c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D02 compound treatment 84000.0 -26000.0 -0.43 32200.0 -91000.0 -1.45 -1.3295 -0.8786 3063268 Maybridge4_000420 FC(F)(F)c1cc(c(Br)c(c1Br)n2cccc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D03 compound treatment 50200.0 -59800.0 -0.99 35800.0 -87400.0 -1.39 -1.6835 -0.9857 1316662 Maybridge4_000421 Clc1ccc(NC(=S)NC(Cn2ccnc2)c3ccccc3)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D04 compound treatment 45880.0 -64100.0 -1.06 37240.0 -86000.0 -1.37 -1.7177 -0.9918 1725083 Maybridge4_000422 Cc1c(N)c2c(cc1N3CCCC3)C(C)(C)CC2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D05 compound treatment 17800.0 -92200.0 -1.52 14440.0 -109000.0 -1.73 -2.3024 -0.9979 1718122 Maybridge4_000423 C1c2sc(Nc3ccccc3)nc2-c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D06 compound treatment 168720.0 58700.0 0.97 145120.0 21900.0 0.35 0.932 0.9048 3178534 Maybridge4_000424 FC(F)(F)c1cc(cc(c1)S(=O)(=O)N=C2NCCCN2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D07 compound treatment 165520.0 55500.0 0.92 137920.0 14700.0 0.23 0.8135 0.8601 1138900 Maybridge4_000425 CC(C)(C)NC(=O)NCc1ccncc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D08 compound treatment 163600.0 53600.0 0.88 126840.0 3600.0 0.06 0.6662 0.7514 3178535 Maybridge4_000426 FC(F)(F)c1cc(NCN2C(=O)CCC2=O)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D09 compound treatment 155600.0 45600.0 0.75 118560.0 -4680.0 -0.07 0.4795 0.634 3178536 Maybridge4_000427 COc1cccc(NC2=C(C#N)C(=O)NC(S2)c3cccc(OC)c3O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D10 compound treatment 150360.0 40400.0 0.67 137120.0 13900.0 0.22 0.6275 0.8939 3063269 Maybridge4_000428 Clc1ccc(cc1)S(=O)(=O)CS(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D11 compound treatment 73080.0 -36900.0 -0.61 40360.0 -82900.0 -1.32 -1.365 -0.9383 1023491 Maybridge4_000429 Oc1ccc(Br)cc1C2Nc3ccccc3S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D12 compound treatment 150480.0 40500.0 0.67 144600.0 21400.0 0.34 0.7132 0.9511 3178537 Maybridge4_000430 C/C(=N\O)/c1nnn(c1C)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D13 compound treatment 163680.0 53700.0 0.89 153280.0 30000.0 0.48 0.9651 0.9583 1381610 Maybridge4_000431 CC1(C)C2CCC(C2)C1(C)NC(=S)NCC3CCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D14 compound treatment 158480.0 48500.0 0.8 124440.0 1200.0 0.02 0.5794 0.7238 3178538 Maybridge4_000432 FC(F)(F)c1cccc(CS(=O)(=O)Cc2cccc(c2)C(F)(F)F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D15 compound treatment 158560.0 48600.0 0.8 105280.0 -18000.0 -0.29 0.3644 0.4281 1650135 Maybridge4_000433 Cc1c(C)c(C)c(C(=O)c2ccccc2C(=O)NCc3cccnc3)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D16 compound treatment 167040.0 57000.0 0.94 158600.0 35400.0 0.56 1.0643 0.9699 1002759 Maybridge4_000434 OC(C(O)C(O)c1nc2ccccc2[nH]1)C(O)c3nc4ccccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D17 compound treatment 106560.0 -3440.0 -0.06 70200.0 -53000.0 -0.85 -0.6379 -0.7529 1658002 Maybridge4_000435 Cc1c(C)c(C)c(CSC2CC(=O)N(C2=O)c3ccccc3)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D18 compound treatment 186040.0 76000.0 1.26 120960.0 -2280.0 -0.04 0.8619 0.6864 3062531 Maybridge4_000436 Clc1ccc(cc1Cl)S(=O)(=O)NC(=N)c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D19 compound treatment 208920.0 98900.0 1.63 175240.0 52000.0 0.83 1.7407 0.9506 2117992 Maybridge4_000437 COc1cccc(/C=N/O)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D20 compound treatment 10840.0 -99200.0 -1.64 8520.0 -115000.0 -1.83 -2.4504 -0.9985 1204180 Maybridge4_000438 Clc1ccc(cc1Cl)S(=O)(=O)NCCc2c[nH]c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D21 compound treatment 161800.0 51800.0 0.86 117680.0 -5560.0 -0.09 0.542 0.6305 3062533 Maybridge4_000439 CS/C(=N\S(=O)(=O)c1ccccc1)/N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D22 compound treatment 150280.0 40300.0 0.66 133360.0 10100.0 0.16 0.5842 0.8539 1417838 Maybridge4_000440 COC(=O)CC1(Oc2ccc(Br)cc2C(=O)N1c3ccc(F)cc3F)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D23 mock treatment 139760.0 29800.0 0.49 121240.0 -2000.0 -0.03 0.3248 0.6599 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 D24 mock treatment 120840.0 10800.0 0.18 105440.0 -17800.0 -0.28 -0.0741 -0.2209 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E01 compound treatment 121520.0 11500.0 0.19 81360.0 -41900.0 -0.67 -0.3375 -0.4863 3062534 Maybridge4_000441 Cn1nc(OC(C)(C)C(=O)Oc2ccc(Cl)cc2Cl)cc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E02 compound treatment 134840.0 24800.0 0.41 119760.0 -3480.0 -0.06 0.2507 0.606 1024184 Maybridge4_000442 CCC(=O)c1ccc(OC)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E03 compound treatment 158280.0 48300.0 0.8 129680.0 6440.0 0.1 0.6361 0.7917 1519339 Maybridge4_000443 Cc1ccc(Oc2ncccc2NC(=O)CSc3ccccn3)c4CCCc41 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E04 compound treatment 161840.0 51800.0 0.86 131080.0 7840.0 0.12 0.6935 0.8019 3062535 Maybridge4_000444 Cc1cc(=O)n(CCO)c(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E05 compound treatment 41440.0 -68600.0 -1.13 33160.0 -90100.0 -1.44 -1.8155 -0.9931 3178539 Maybridge4_000445 OC(=O)CC(C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C2=CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E06 compound treatment 133960.0 24000.0 0.4 97680.0 -25600.0 -0.41 -0.0084 -0.0148 1643916 Maybridge4_000446 O=C(N1CCCCC1)c2cccc3Cc4ccccc4-c32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E07 compound treatment 163640.0 53600.0 0.89 122000.0 -1240.0 -0.02 0.6121 0.6912 3178540 Maybridge4_000447 OC(=O)c1oc(C(=O)O)c(OCc2ccccc2)c1OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E08 compound treatment 160960.0 51000.0 0.84 143520.0 20300.0 0.32 0.8234 0.9137 3062536 Maybridge4_000448 O=C(Oc1ccccc1)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E09 compound treatment 150640.0 40600.0 0.67 121880.0 -1360.0 -0.02 0.459 0.6839 1039079 Maybridge4_000449 OC(=O)c1cccc(Cl)c1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E10 compound treatment 159640.0 49600.0 0.82 148600.0 25400.0 0.4 0.8652 0.947 1423015 Maybridge4_000450 CC(=O)N[C@@H](Cc1ccccc1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E11 compound treatment 151920.0 41900.0 0.69 134400.0 11200.0 0.18 0.6151 0.8609 3178542 Maybridge4_000451 OC(Cn1ccccc1=N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E12 compound treatment 134360.0 24400.0 0.4 114400.0 -8840.0 -0.14 0.1847 0.4336 3062537 Maybridge4_000452 CC(C1CC1)N(C(=O)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E13 compound treatment 163160.0 53200.0 0.88 160160.0 36900.0 0.59 1.0366 0.9811 1704451 Maybridge4_000453 CN(C)C(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E14 compound treatment 156400.0 46400.0 0.77 145560.0 22300.0 0.36 0.7931 0.9392 3178543 Maybridge4_000454 CC(C)(C)C(=O)Nc1ccn([C@H]2C[C@H](O)[C@@H](COC(=O)C(C)(C)C)O2)c(=O)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E15 compound treatment 129360.0 19400.0 0.32 110040.0 -13200.0 -0.21 0.0772 0.2018 3062540 Maybridge4_000455 COc1ccc2c(OC)ccc3C(=O)C=Cc1c32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E16 compound treatment 122680.0 12700.0 0.21 107120.0 -16100.0 -0.26 -0.0337 -0.1016 1289531 Maybridge4_000456 Clc1ccc(cc1)C(=O)OC2CN3CCC2CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E17 compound treatment 189920.0 79900.0 1.32 136680.0 13400.0 0.21 1.0843 0.8113 1672892 Maybridge4_000457 CNC(=O)c1ccccc1S(=O)c2cccc3cccc(C(=O)O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E18 compound treatment 131480.0 21500.0 0.35 126280.0 3040.0 0.05 0.285 0.7964 3062541 Maybridge4_000458 COc1ccc(OC)c(CCCCc2cc(OC)ccc2OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E19 compound treatment 16520.0 -93500.0 -1.54 11400.0 -112000.0 -1.78 -2.3516 -0.9974 3178544 Maybridge4_000459 Clc1ccc(S/C=C/C(=O)c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E20 compound treatment 12120.0 -97900.0 -1.62 9080.0 -114000.0 -1.82 -2.4291 -0.9982 3062542 Maybridge4_000460 C/C(=N\O)/C1(CC2(C)CC3(C)CC(C)(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E21 compound treatment 146480.0 36500.0 0.6 115000.0 -8240.0 -0.13 0.3329 0.5402 3178545 Maybridge4_000461 CC(=O)OC[C@H]1O[C@@H](Nc2ccc(C)cc2)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E22 compound treatment 144920.0 34900.0 0.58 132440.0 9200.0 0.15 0.5113 0.8596 3062543 Maybridge4_000462 CC1(C)N(O)C(NC1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E23 mock treatment 123400.0 13400.0 0.22 135360.0 12100.0 0.19 0.293 0.9977 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 E24 mock treatment 86960.0 -23000.0 -0.38 98800.0 -24400.0 -0.39 -0.5444 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F01 compound treatment 18080.0 -91900.0 -1.52 21040.0 -102000.0 -1.63 -2.2247 -0.9994 3178546 Maybridge4_000463 Fc1ccc2CC(=O)C(Cc2c1)C3=Cc4ccc(F)cc4CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F02 compound treatment 141440.0 31400.0 0.52 102720.0 -20500.0 -0.33 0.1357 0.2213 1526672 Maybridge4_000464 COc1ccc(CCNC(=O)c2nc3ccccc3c(=O)n2n4cccc4)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F03 compound treatment 129200.0 19200.0 0.32 129000.0 5760.0 0.09 0.289 0.876 3062544 Maybridge4_000465 CC(OC(=O)c1cccc(Cl)c1)c2ccc[n+](C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F04 compound treatment 57480.0 -52500.0 -0.87 54480.0 -68800.0 -1.1 -1.388 -0.9933 1352177 Maybridge4_000466 CSc1cccc(NC(=S)Nc2cc3c(c(N)c2C)C(C)(C)CC3(C)C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F05 compound treatment 196920.0 86900.0 1.43 155520.0 32300.0 0.51 1.3784 0.9043 3062545 Maybridge4_000467 CC(C=C1C(=O)NC(=O)NC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F06 compound treatment 34560.0 -75400.0 -1.25 27240.0 -96000.0 -1.53 -1.9625 -0.9948 3062546 Maybridge4_000468 SC1=NC2(CCCC2)NN1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F07 compound treatment 172160.0 62200.0 1.03 109920.0 -13300.0 -0.21 0.5754 0.5492 3178547 Maybridge4_000469 C(c1ccc(/N=C/c2ccccn2)cc1)c3ccc(/N=C/c4ccccn4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F08 compound treatment 178520.0 68500.0 1.13 135200.0 12000.0 0.19 0.9346 0.8148 1528873 Maybridge4_000470 O=C1CCC(=O)N1CNc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F09 compound treatment 152160.0 42200.0 0.7 132120.0 8880.0 0.14 0.5922 0.8339 1318293 Maybridge4_000471 CC(C)(C)C(=O)Nc1ccccc1C(=O)NCc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F10 compound treatment 11880.0 -98100.0 -1.62 9800.0 -113000.0 -1.81 -2.4238 -0.9985 3178548 Maybridge4_000472 Clc1ccc(SCc2ccc(NC(=O)Nc3cccc(Cl)c3)o2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F11 compound treatment 15720.0 -94300.0 -1.56 11360.0 -112000.0 -1.78 -2.3614 -0.9977 3062547 Maybridge4_000473 NC(=N)Nc1nc(cs1)c2ccc(cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F12 compound treatment 13080.0 -96900.0 -1.6 11880.0 -111000.0 -1.77 -2.3863 -0.9987 3178625 Maybridge4_000474 CS/C(=C(/C#N)\C(=O)c1cccs1)/Nc2cccc(Cl)c2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F13 compound treatment 137440.0 27400.0 0.45 142320.0 19100.0 0.3 0.5353 0.9812 3178626 Maybridge4_000475 OC(Cc1ccccc1)(c2ccccc2)c3ccccc3NC(=S)NC4CC5CC4C=C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F14 compound treatment 177840.0 67800.0 1.12 162400.0 39200.0 0.62 1.2332 0.9619 3062548 Maybridge4_000476 Cc1nnsc1C(=O)Nc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F15 compound treatment 62360.0 -47600.0 -0.79 56360.0 -66900.0 -1.07 -1.3098 -0.9888 1004988 Maybridge4_000477 ON=C(Cc1ccccc1)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F16 compound treatment 124840.0 14800.0 0.24 108280.0 -15000.0 -0.24 0.0046 0.0135 3178627 Maybridge4_000478 Cc1onc(c1C(=O)NC(=S)N2CCOCC2)c3c(Cl)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F17 compound treatment 182920.0 72900.0 1.2 143440.0 20200.0 0.32 1.0788 0.8658 3062549 Maybridge4_000479 NC(=O)Nc1ccc(cc1)/C(=C/c2ccncc2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F18 compound treatment 80800.0 -29200.0 -0.48 71120.0 -52100.0 -0.83 -0.9282 -0.9665 3062550 Maybridge4_000480 CN(C)C(=S)SCc1c(C)c(C)c(C)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F19 compound treatment 108760.0 -1240.0 -0.02 73520.0 -49700.0 -0.79 -0.5748 -0.7252 3178628 Maybridge4_000481 COc1ccc(cc1)n2c(CC#N)nnc2SCc3c(C)c(C)c(C)c(C)c3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F20 compound treatment 160600.0 50600.0 0.84 128400.0 5160.0 0.08 0.6488 0.773 3178629 Maybridge4_000482 CC1(C)ON(C(=N1)NC(=O)NC(=O)c2ccccc2Cl)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F21 compound treatment 162360.0 52400.0 0.86 128680.0 5440.0 0.09 0.6725 0.7742 3062551 Maybridge4_000483 O=S(=O)(/N=C/1\NCC2CCCC2N1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F22 compound treatment 178880.0 68900.0 1.14 107800.0 -15400.0 -0.25 0.63 0.5415 3178630 Maybridge4_000484 CC(CO)(CO)NC(=S)Nc1ccc(F)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F23 mock treatment 124520.0 14500.0 0.24 119960.0 -3280.0 -0.05 0.1325 0.5403 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 F24 mock treatment 118720.0 8720.0 0.14 102760.0 -20500.0 -0.33 -0.129 -0.3617 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G01 compound treatment 110000.0 -2.5 0.0 114000.0 -9240.0 -0.15 -0.1041 -0.7073 1441207 Maybridge4_000485 CC(C)(C)c1cc2[nH]c(=N)[nH]c(=N)n2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G02 compound treatment 56240.0 -53800.0 -0.89 50240.0 -73000.0 -1.16 -1.4502 -0.9911 1390371 Maybridge4_000486 O=c1c(Cc2ccccc2OCc3ccccc3)coc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G03 compound treatment 129600.0 19600.0 0.32 136600.0 13400.0 0.21 0.3793 0.9794 3062552 Maybridge4_000487 COc1ccccc1C2OC(=O)C[C@H]2C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G04 compound treatment 71880.0 -38100.0 -0.63 94640.0 -28600.0 -0.46 -0.7673 -0.9875 1630105 Maybridge4_000488 Brc1ccc(cc1)C(=O)c2cc3OCCCOc3cc2Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G05 compound treatment 147480.0 37500.0 0.62 141560.0 18300.0 0.29 0.644 0.9413 1255736 Maybridge4_000489 COc1cc(OC)nc(NCC(NC(=O)c2ccccc2)C(=O)N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G06 compound treatment 152720.0 42700.0 0.71 150040.0 26800.0 0.43 0.8007 0.9712 1191076 Maybridge4_000490 CNc1cc(=O)n(c2ccccc2)c(=O)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G07 compound treatment 152800.0 42800.0 0.71 136480.0 13200.0 0.21 0.6488 0.8799 1024944 Maybridge4_000491 CCOC(=O)c1oc(C(=O)OCC)c(O)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G08 compound treatment 105920.0 -4080.0 -0.07 104480.0 -18800.0 -0.3 -0.2591 -0.8453 3062592 Maybridge4_000492 CC(C)(C)c1ccc2cc(C#N)c(C#N)cc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G09 compound treatment 147280.0 37300.0 0.62 139200.0 16000.0 0.25 0.615 0.9236 3062593 Maybridge4_000493 O=C1N(CCCCN2C(=O)c3ccccc3S2(=O)=O)S(=O)(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G10 compound treatment 27200.0 -82800.0 -1.37 25040.0 -98200.0 -1.57 -2.0732 -0.9977 3062594 Maybridge4_000494 Cc1ccc(NC(=O)N(C2=NCC(C)(C)S2)c3ccc(F)c(Cl)c3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G11 compound treatment 144880.0 34900.0 0.58 140280.0 17000.0 0.27 0.5992 0.9412 1051499 Maybridge4_000495 CC(O)c1ccc2ccccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G12 compound treatment 143840.0 33800.0 0.56 153000.0 29800.0 0.47 0.7304 0.9967 1332464 Maybridge4_000496 OCCOC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G13 compound treatment 142800.0 32800.0 0.54 155400.0 32200.0 0.51 0.7453 0.9996 1397918 Maybridge4_000497 CCCN(CCC)C(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G14 compound treatment 161440.0 51400.0 0.85 165520.0 42300.0 0.67 1.0769 0.9935 3178631 Maybridge4_000498 CC(C)(C)C(=O)OC[C@H]1O[C@H](C[C@@H]1OC(=O)C(C)(C)C)n2cnc3c(N)ncnc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G15 compound treatment 161680.0 51700.0 0.85 132560.0 9320.0 0.15 0.7083 0.818 3062595 Maybridge4_000499 O=C(OC1=CC(=O)c2cccc3cccc1c23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G16 compound treatment 97080.0 -12900.0 -0.21 88920.0 -34300.0 -0.55 -0.5376 -0.9157 1645132 Maybridge4_000500 O=C(NC1CCN(Cc2cccc3ccccc23)CC1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G17 compound treatment 158080.0 48100.0 0.79 137400.0 14200.0 0.23 0.7208 0.8736 1430296 Maybridge4_000501 OCc1cccc2cccc(S(=O)c3cccc4cccc(C(=O)O)c34)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G18 compound treatment 115880.0 5880.0 0.1 120040.0 -3200.0 -0.05 0.0326 0.2972 1284168 Maybridge4_000502 Brc1ccc(Cc2csc3ccccc3c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G19 compound treatment 140320.0 30300.0 0.5 128440.0 5200.0 0.08 0.4125 0.8132 3178632 Maybridge4_000503 FC(F)(F)Oc1ccccc1NC(=O)CC(=O)Nc2ccccc2OC(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G20 compound treatment 147960.0 38000.0 0.63 143120.0 19900.0 0.32 0.6671 0.9501 1186920 Maybridge4_000504 NNC(=O)C1(CCCC2CCC1)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G21 compound treatment 15840.0 -94200.0 -1.55 15160.0 -108000.0 -1.72 -2.3172 -0.9987 3062596 Maybridge4_000505 FC1(C(=O)Nc2c(Cl)c(Cl)ccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G22 compound treatment 136960.0 27000.0 0.44 133120.0 9880.0 0.16 0.426 0.9025 3178633 Maybridge4_000506 CC(C)(C)OC(=O)Cn1ccc(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G23 mock treatment 134840.0 24800.0 0.41 111720.0 -11500.0 -0.18 0.1601 0.3564 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 G24 mock treatment 94120.0 -15900.0 -0.26 121440.0 -1800.0 -0.03 -0.2056 -0.7797 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H01 compound treatment 111560.0 1560.0 0.03 106120.0 -17100.0 -0.27 -0.1747 -0.6376 3178634 Maybridge4_000507 O/N=C(/C1CC2CCC1CC2)\c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H02 compound treatment 72000.0 -38000.0 -0.63 87840.0 -35400.0 -0.56 -0.8425 -0.9986 1138209 Maybridge4_000508 N1C(c2cccn2-c3ccccc13)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H03 compound treatment 54880.0 -55100.0 -0.91 67640.0 -55600.0 -0.89 -1.27 -0.9999 1326325 Maybridge4_000509 Cc1c(C)c(C)c(CN2C(=O)c3ccccc3C2=O)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H04 compound treatment 158520.0 48500.0 0.8 145040.0 21800.0 0.35 0.812 0.9301 3062597 Maybridge4_000510 Cc1c(cc2c(c1n3cccc3)C(C)(C)CC2(C)C)N4CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H05 compound treatment 13240.0 -96800.0 -1.6 19960.0 -103000.0 -1.65 -2.2934 -0.9999 3178635 Maybridge4_000511 Fc1ccc(cc1)C(=O)CSc2nsc(SCC(=O)c3ccc(F)cc3)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H06 compound treatment 8120.0 -102000.0 -1.68 9200.0 -114000.0 -1.82 -2.4744 -0.9992 3178636 Maybridge4_000512 CC(C)C1CCC(C)CC1NC(=S)Nc2cccc(F)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H07 compound treatment 99080.0 -10900.0 -0.18 100880.0 -22400.0 -0.36 -0.3795 -0.9502 1248377 Maybridge4_000513 CC1CCCCN1C(=S)Nc2ccc(cc2)S(=O)(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H08 compound treatment 130480.0 20500.0 0.34 113040.0 -10200.0 -0.16 0.1241 0.3309 3178637 Maybridge4_000514 COc1cccc(OC)c1C(=O)Nc2cc(c(Cl)cc2OC)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H09 compound treatment 153400.0 43400.0 0.72 160360.0 37100.0 0.59 0.9249 0.9955 1054040 Maybridge4_000515 CC(C)C1=NNC(=O)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H10 compound treatment 154840.0 44800.0 0.74 160480.0 37200.0 0.59 0.9431 0.994 1253333 Maybridge4_000516 Nc1nc2c(nnn2c3ccccc13)C(=O)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H11 compound treatment 140920.0 30900.0 0.51 143160.0 19900.0 0.32 0.5854 0.9739 1700266 Maybridge4_000517 COc1ccc(CCNC(=S)NCCc2ccccc2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H12 compound treatment 169080.0 59100.0 0.98 164920.0 41700.0 0.66 1.1593 0.9825 3178638 Maybridge4_000518 O/N=C(\C#N)/C(=O)c1ccco1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H13 compound treatment 151800.0 41800.0 0.69 174320.0 51100.0 0.81 1.0636 0.9966 1672819 Maybridge4_000519 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H14 compound treatment 166840.0 56800.0 0.94 152000.0 28800.0 0.46 0.9876 0.9457 3178639 Maybridge4_000520 Fc1cc(F)c(NC(=S)N2CCOCC2)c(F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H15 compound treatment 132520.0 22500.0 0.37 132040.0 8800.0 0.14 0.362 0.9113 1546700 Maybridge4_000521 Cc1c(C)c(C)c(C(=O)c2ccccc2C(=O)NN)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H16 compound treatment 132200.0 22200.0 0.37 126480.0 3240.0 0.05 0.2956 0.7989 3062598 Maybridge4_000522 Fc1cccc(NCc2cccs2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H17 compound treatment 150800.0 40800.0 0.67 150280.0 27000.0 0.43 0.781 0.9767 3178640 Maybridge4_000523 NC(=O)Nc1ccc(cc1)/C(=C/c2ccc(Cl)c(Cl)c2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H18 compound treatment 147480.0 37500.0 0.62 157920.0 34700.0 0.55 0.8283 0.9984 3062599 Maybridge4_000524 CN(C)C(=S)SCC(=O)c1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H19 compound treatment 10160.0 -99800.0 -1.65 10400.0 -113000.0 -1.8 -2.4371 -0.9991 1221296 Maybridge4_000525 Cc1cc(C)c2-c3[nH]c(nc3C(C)(C)Cc2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H20 compound treatment 74200.0 -35800.0 -0.59 101960.0 -21300.0 -0.34 -0.6577 -0.9652 1556252 Maybridge4_000526 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H21 compound treatment 131160.0 21200.0 0.35 140200.0 17000.0 0.27 0.4381 0.992 3062600 Maybridge4_000527 CC1CN/C(=N/S(=O)(=O)c2ccccc2)/N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H22 compound treatment 124360.0 14400.0 0.24 133480.0 10200.0 0.16 0.283 0.9834 1621149 Maybridge4_000528 CC1CC(C)CN(C1)c2ccc(NS(=O)(=O)c3ccccc3)cc2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H23 mock treatment 144360.0 34400.0 0.57 131320.0 8080.0 0.13 0.4921 0.8462 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 H24 mock treatment 89360.0 -20600.0 -0.34 102880.0 -20400.0 -0.32 -0.4704 -0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I01 compound treatment 5520.0 -104000.0 -1.72 9600.0 -114000.0 -1.81 -2.5003 -0.9997 3062601 Maybridge4_000529 Cc1ccc(Oc2ncc(cc2Cl)C(F)(F)F)c3CCCc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I02 compound treatment 37560.0 -72400.0 -1.2 96160.0 -27100.0 -0.43 -1.1507 -0.9052 3178641 Maybridge4_000530 CCOC(=O)CSc1nnc(S)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I03 compound treatment 44440.0 -65600.0 -1.08 64160.0 -59100.0 -0.94 -1.4311 -0.9976 3178642 Maybridge4_000531 Cc1nc(cs1)c2cc(C#N)c(SCCNS(=O)(=O)c3ccc(cc3)C(C)(C)C)nc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I04 compound treatment 112000.0 2000.0 0.03 154000.0 30800.0 0.49 0.37 0.753 1202864 Maybridge4_000532 Cc1ccc(cc1)C(=O)C2C(=O)N(C(=O)N(C2=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I05 compound treatment 42040.0 -68000.0 -1.12 73040.0 -50200.0 -0.8 -1.359 -0.9863 1219965 Maybridge4_000533 Cc1nn(nc1C(=O)ON2C(=O)C3C4OC(C=C4)C3C2=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I06 compound treatment 30280.0 -79700.0 -1.32 28880.0 -94400.0 -1.5 -1.994 -0.9978 3062602 Maybridge4_000534 COc1ccc(/C=C\2/C(Oc3ccccc3C2=O)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I07 compound treatment 105200.0 -4800.0 -0.08 131800.0 8560.0 0.14 0.0404 0.2563 1277364 Maybridge4_000535 CCOC(=O)c1c(O)c(O)c(C(=O)OCC)n1c2ccc(OC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I08 compound treatment 124160.0 14200.0 0.23 156720.0 33500.0 0.53 0.5426 0.9314 1178381 Maybridge4_000536 Fc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I09 compound treatment 64520.0 -45500.0 -0.75 60480.0 -62800.0 -1.0 -1.2382 -0.99 1497959 Maybridge4_000537 CC(C)C1CCC(C)CC1NC(=O)c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I10 compound treatment 126720.0 16700.0 0.28 138400.0 15200.0 0.24 0.366 0.9978 1039563 Maybridge4_000538 Clc1ccc2oc(cc(=O)c2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I11 compound treatment 153880.0 43900.0 0.72 159160.0 35900.0 0.57 0.917 0.9932 1035419 Maybridge4_000539 O=C(c1ccccc1)c2ccc(cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I12 compound treatment 179080.0 69100.0 1.14 171800.0 48600.0 0.77 1.3536 0.9822 3178724 Maybridge4_000540 Sc1nn(c2ccc(Cl)cc2)c(=S)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I13 compound treatment 205120.0 95100.0 1.57 176600.0 53400.0 0.85 1.7117 0.9585 1060199 Maybridge4_000541 CNC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I14 compound treatment 157080.0 47100.0 0.78 155560.0 32300.0 0.52 0.9138 0.9801 3178725 Maybridge4_000542 NNC(=O)c1cc(n[nH]1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I15 compound treatment 161600.0 51600.0 0.85 168000.0 44800.0 0.71 1.1067 0.9961 1005720 Maybridge4_000543 CN(C)c1ccc(Cc2ccc(cc2)N(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I16 compound treatment 23760.0 -86200.0 -1.42 33680.0 -89600.0 -1.43 -2.016 -1.0 1587057 Maybridge4_000544 COc1ccccc1C2CCN(Cc3cccc4ccccc34)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I17 compound treatment 144960.0 35000.0 0.58 163480.0 40200.0 0.64 0.8616 0.9986 2075442 Maybridge4_000545 CN1[S+](c2ccccc2C(=O)O)c3cccc4cccc(C1=O)c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I18 compound treatment 13760.0 -96200.0 -1.59 19560.0 -104000.0 -1.65 -2.2918 -0.9998 3178726 Maybridge4_000546 Nc1ccccc1SC(CC(=O)c2ccc(Br)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I19 compound treatment 9200.0 -101000.0 -1.66 11160.0 -112000.0 -1.79 -2.4397 -0.9994 1287387 Maybridge4_000547 OCC(O)Cn1c2ccc(Br)cc2c3cc(Br)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I20 compound treatment 162600.0 52600.0 0.87 179160.0 55900.0 0.89 1.2442 0.9999 1441014 Maybridge4_000548 OC(=O)C1(CCCC2(CCC1)C(=O)O)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I21 compound treatment 108480.0 -1520.0 -0.03 127560.0 4320.0 0.07 0.0309 0.422 1343250 Maybridge4_000549 O=C1C(C2c3ccccc3Oc4ccccc24)C(=O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I22 compound treatment 65920.0 -44100.0 -0.73 79280.0 -44000.0 -0.7 -1.01 -0.9998 3062641 Maybridge4_000550 OC[C@H]1O[C@@H](Oc2c[nH]c3ccc(Br)c(Cl)c23)[C@H](O)[C@@H](O)[C@H]1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I23 mock treatment 121960.0 12000.0 0.2 150440.0 27200.0 0.43 0.4462 0.9365 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 I24 mock treatment 91000.0 -19000.0 -0.31 107960.0 -15300.0 -0.24 -0.394 -0.9922 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J01 compound treatment 105320.0 -4680.0 -0.08 144400.0 21200.0 0.34 0.1839 0.5313 3062642 Maybridge4_000551 COC(=O)C1CCC(=O)C(C1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J02 compound treatment 10800.0 -99200.0 -1.64 26840.0 -96400.0 -1.54 -2.2444 -0.9995 1601179 Maybridge4_000552 Oc1ccc2ccccc2c1C3Nc4ccccc4-n5cccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J03 compound treatment 45320.0 -64700.0 -1.07 77800.0 -45400.0 -0.72 -1.2671 -0.9821 3062643 Maybridge4_000553 Cc1c(C)c(C)c(CN2CCCCC2)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J04 compound treatment 64080.0 -45900.0 -0.76 74760.0 -48500.0 -0.77 -1.0824 -1.0 3062644 Maybridge4_000554 CC(=O)Nc1s/c(=N\c2ccc(C)c(C)c2)/n(C(=O)C)c1c3ccc4OCOc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J05 compound treatment 50400.0 -59600.0 -0.98 101160.0 -22100.0 -0.35 -0.9445 -0.9039 1342204 Maybridge4_000555 O=S(=O)(N1CCCCC1)c2ccc(NC(=S)Nc3ccc4OCOc4c3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J06 compound treatment 7320.0 -103000.0 -1.7 9800.0 -113000.0 -1.81 -2.477 -0.9995 3062645 Maybridge4_000556 Clc1ccc(Cl)c(NC(=S)NC(=N)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J07 compound treatment 33920.0 -76100.0 -1.26 61760.0 -61500.0 -0.98 -1.5809 -0.9925 3178727 Maybridge4_000557 Oc1c(Cl)cc(Cl)cc1/C=N/c2ccc(CC3C(=O)Nc4ccccc34)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J08 compound treatment 159520.0 49500.0 0.82 158400.0 35200.0 0.56 0.9743 0.9831 3178728 Maybridge4_000558 CN1CCC2(C(C1)N=NN2c3cc(cc(c3)C(F)(F)F)C(F)(F)F)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J09 compound treatment 46640.0 -63400.0 -1.05 73400.0 -49800.0 -0.79 -1.3013 -0.9908 3062646 Maybridge4_000559 Cc1cc(C)c(C(=O)Nc2cccc(c2)C(F)(F)F)c3CC(C)(C)C(=O)c31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J10 compound treatment 127000.0 17000.0 0.28 155440.0 32200.0 0.51 0.5613 0.9596 1734956 Maybridge4_000560 Nc1nc2c(nnn2c3ccccc13)c4ccc(Br)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J11 compound treatment 13720.0 -96300.0 -1.59 14800.0 -108000.0 -1.73 -2.346 -0.9991 3178729 Maybridge4_000561 Cc1c(C)c(C)c(C(O)c2ccccc2)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J12 compound treatment 146600.0 36600.0 0.6 138560.0 15300.0 0.24 0.5999 0.9206 3178730 Maybridge4_000562 COc1ccc(cc1)c2c(C#N)nnn2c3cc(cc(c3)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J13 compound treatment 164640.0 54600.0 0.9 178440.0 55200.0 0.88 1.2599 0.9999 1646858 Maybridge4_000563 CCN1C(C(CCC1=O)C(=O)O)c2ccc(OC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J14 compound treatment 189000.0 79000.0 1.3 171000.0 47800.0 0.76 1.4604 0.9672 1299644 Maybridge4_000564 Fc1cccc(NCCc2ccccn2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J15 compound treatment 97640.0 -12400.0 -0.2 137520.0 14300.0 0.23 0.0167 0.0545 3062647 Maybridge4_000565 CCOC(=S)SCc1c(C)c(C)c(C)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J16 compound treatment 134960.0 25000.0 0.41 164360.0 41100.0 0.66 0.7548 0.975 1536926 Maybridge4_000566 O=C(CC#N)NCc1cccs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J17 compound treatment 38480.0 -71500.0 -1.18 64040.0 -59200.0 -0.94 -1.502 -0.9938 3178731 Maybridge4_000567 Cc1onc(c1NC(=O)Nc2cccc(c2)C(F)(F)F)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J18 compound treatment 66320.0 -43700.0 -0.72 166160.0 42900.0 0.68 -0.0261 -0.0263 1727398 Maybridge4_000568 CCc1cccc(C(C)C)c1NS(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J19 compound treatment 126880.0 16900.0 0.28 159040.0 35800.0 0.57 0.6005 0.9456 3062649 Maybridge4_000569 Nn1c(nc2ccccc2c1=O)C(=O)NCc3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J20 compound treatment 100600.0 -9400.0 -0.16 149240.0 26000.0 0.41 0.1833 0.4142 3178732 Maybridge4_000570 CC1CCCCN1CCCNC(=O)Nc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J21 compound treatment 120440.0 10400.0 0.17 156440.0 33200.0 0.53 0.496 0.8913 3062650 Maybridge4_000571 Clc1ccc(SCc2ccc(C#N)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J22 compound treatment 142640.0 32600.0 0.54 142080.0 18800.0 0.3 0.5933 0.9619 3178733 Maybridge4_000572 CC1CN(CC(C)O1)c2ccc(NC(=O)c3ccco3)cc2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J23 mock treatment 137120.0 27100.0 0.45 136920.0 13700.0 0.22 0.4707 0.9454 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 J24 mock treatment 98000.0 -12000.0 -0.2 114360.0 -8880.0 -0.14 -0.2401 -0.9864 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K01 compound treatment 36880.0 -73100.0 -1.21 97800.0 -25400.0 -0.41 -1.1402 -0.8955 1258100 Maybridge4_000573 OC(=O)C1CC1C(=O)Nc2ccc(Oc3ccc(Cl)cc3C4CCCCC4)nc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K02 compound treatment 80920.0 -29100.0 -0.48 118640.0 -4600.0 -0.07 -0.3913 -0.8057 3062651 Maybridge4_000574 CCOC(=O)CCSc1nnc(S)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K03 compound treatment 46640.0 -63400.0 -1.05 57680.0 -65600.0 -1.04 -1.4784 -1.0 1465836 Maybridge4_000575 Fc1ccc(COc2ccc(cc2)C(=O)CSc3ccccn3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K04 compound treatment 75280.0 -34700.0 -0.57 144000.0 20800.0 0.33 -0.1713 -0.2588 1182542 Maybridge4_000576 CC1(CC2(C)CC3(C)C1)CC(C2)(C3)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K05 compound treatment 21920.0 -88100.0 -1.45 32960.0 -90300.0 -1.44 -2.0456 -1.0 3178734 Maybridge4_000577 OC1CCCCCCCCCCC1CCC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K06 compound treatment 125680.0 15700.0 0.26 145680.0 22400.0 0.36 0.4359 0.9874 3062652 Maybridge4_000578 CC(C)CCNC(=O)Oc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K07 compound treatment 129120.0 19100.0 0.32 157720.0 34500.0 0.55 0.6118 0.9653 3178735 Maybridge4_000579 COc1ccc(OC)c2c(=O)cc(oc12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K08 compound treatment 104720.0 -5280.0 -0.09 137880.0 14600.0 0.23 0.1034 0.4149 1674875 Maybridge4_000580 COc1ccccc1C2CCN(CC2)C(=O)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K09 compound treatment 51760.0 -58200.0 -0.96 66760.0 -56500.0 -0.9 -1.3163 -0.9995 3178736 Maybridge4_000581 CC1(C)C2CCC1(C)C(C2)NC(=O)c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K10 compound treatment 103240.0 -6760.0 -0.11 147040.0 23800.0 0.38 0.1893 0.4787 1672849 Maybridge4_000582 Cc1onc(c1C(=O)N2CC(C2)Oc3ccc(Cl)cc3)c4c(F)cccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K11 compound treatment 152120.0 42100.0 0.7 164000.0 40800.0 0.65 0.951 0.9994 3062653 Maybridge4_000583 Cc1cc(n[nH]c1=O)c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K12 compound treatment 148960.0 39000.0 0.64 158280.0 35000.0 0.56 0.8497 0.9975 3062654 Maybridge4_000584 Sc1nc(c2ccccc2)n(n1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K13 compound treatment 89560.0 -20400.0 -0.34 123240.0 2.5 0.0 -0.2386 -0.707 1267527 Maybridge4_000585 CC(C)CCNC(=O)c1cccc2C(=O)c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K14 compound treatment 134800.0 24800.0 0.41 152600.0 29400.0 0.47 0.6204 0.9978 3062655 Maybridge4_000586 O=C1C(CCCC1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K15 compound treatment 115280.0 5280.0 0.09 159440.0 36200.0 0.58 0.4696 0.8047 3178737 Maybridge4_000587 Cc1c(cnc2ccccc12)c3nnnn3c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K16 compound treatment 53800.0 -56200.0 -0.93 147120.0 23900.0 0.38 -0.3869 -0.3858 1175626 Maybridge4_000588 Cc1ccc(cc1)C(=O)OC2CN3CCC2CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K17 compound treatment 107840.0 -2160.0 -0.04 158200.0 35000.0 0.56 0.3688 0.6605 3178738 Maybridge4_000589 CN1[S+](c2ccccc2C1=O)c3cccc4cccc(C(=O)O)c34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K18 compound treatment 8720.0 -101000.0 -1.67 14520.0 -109000.0 -1.73 -2.4075 -0.9998 3178739 Maybridge4_000590 CC1(C)C2CCC1(C)c3nn(c(c23)C(F)(F)F)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K19 compound treatment 133880.0 23900.0 0.39 152960.0 29700.0 0.47 0.6137 0.9958 1361703 Maybridge4_000591 CCOC(Cn1c2ccccc2c3ccccc13)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K20 compound treatment 125640.0 15600.0 0.26 148040.0 24800.0 0.4 0.4621 0.9787 1031191 Maybridge4_000592 OC(=O)C1C(C2CCC1C2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K21 compound treatment 120840.0 10800.0 0.18 154920.0 31700.0 0.5 0.4836 0.9026 1224135 Maybridge4_000593 Cn1c(nc2ccccc12)C(C#N)C(=O)c3ccccc3I 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K22 compound treatment 82600.0 -27400.0 -0.45 123560.0 323.0 0.01 -0.3162 -0.699 1062658 Maybridge4_000594 CCOC(=O)C1C(C2c3ccccc3C1c4ccccc24)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K23 mock treatment 127760.0 17800.0 0.29 134760.0 11500.0 0.18 0.3371 0.9746 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 K24 mock treatment 81200.0 -28800.0 -0.48 139000.0 15800.0 0.25 -0.1585 -0.2948 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L01 compound treatment 36480.0 -73500.0 -1.21 146120.0 22900.0 0.36 -0.6003 -0.4737 3062656 Maybridge4_000595 CCCCN(C(C)C)S(=O)(=O)c1ccc(C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L02 compound treatment 27400.0 -82600.0 -1.36 49040.0 -74200.0 -1.18 -1.8004 -0.9975 3178740 Maybridge4_000596 FC(F)(F)c1cccc(c1)/C(=C/C=C/c2ccccc2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L03 compound treatment 65240.0 -44800.0 -0.74 151200.0 28000.0 0.45 -0.2073 -0.2403 3062657 Maybridge4_000597 O=C1NC(=O)C(=CC2CCC=CC2)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L04 compound treatment 79760.0 -30200.0 -0.5 164040.0 40800.0 0.65 0.1069 0.1303 1174872 Maybridge4_000598 Fc1cccc(F)c1C(=O)Nc2cccc(NC(=O)c3c(F)cccc3F)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L05 compound treatment 114600.0 4600.0 0.08 154280.0 31000.0 0.49 0.4035 0.8061 3178741 Maybridge4_000599 COc1ccc(CC/N=C/c2ccc3OCOc3c2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L06 compound treatment 11200.0 -98800.0 -1.63 17440.0 -106000.0 -1.69 -2.3456 -0.9999 3062658 Maybridge4_000600 FC(F)(F)c1cc(C#CCN2CCCCC2)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L07 compound treatment 119480.0 9480.0 0.16 152320.0 29100.0 0.46 0.4384 0.8961 3178820 Maybridge4_000601 CC(C)NC(=S)N1CCCN2C1c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L08 compound treatment 43920.0 -66100.0 -1.09 53360.0 -69900.0 -1.11 -1.5589 -0.9999 3062659 Maybridge4_000602 FC(F)(F)c1cccc(c1C(=O)OCC(=O)c2ccc(Cl)cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L09 compound treatment 89320.0 -20700.0 -0.34 147720.0 24500.0 0.39 0.0345 0.0666 1236762 Maybridge4_000603 S=C(Nc1ccccc1)Nc2ccccc2n3cccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L10 compound treatment 114960.0 4960.0 0.08 169200.0 46000.0 0.73 0.5759 0.7812 3062660 Maybridge4_000604 COc1ccc(OC)c(c1)S(=O)(=O)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L11 compound treatment 143960.0 34000.0 0.56 149760.0 26500.0 0.42 0.6953 0.9903 1138158 Maybridge4_000605 COc1ccc(OCCC(=O)NN)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L12 compound treatment 159240.0 49200.0 0.81 162000.0 38800.0 0.62 1.0116 0.9908 3062661 Maybridge4_000606 CN(C)C(=O)c1c(C)onc1c2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L13 compound treatment 128800.0 18800.0 0.31 135520.0 12300.0 0.2 0.3578 0.9753 3178821 Maybridge4_000607 OC(Cc1ccccc1)(c2ccccc2)c3ccccc3/N=C/c4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L14 compound treatment 13080.0 -96900.0 -1.6 20320.0 -103000.0 -1.64 -2.2912 -0.9999 3178822 Maybridge4_000608 Fc1cccc(N(Cc2cccnc2)C(=S)Nc3ccc(Cl)c(Cl)c3)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L15 compound treatment 41400.0 -68600.0 -1.13 174760.0 51500.0 0.82 -0.2201 -0.1573 3062708 Maybridge4_000609 Cc1c(C)c(C)c(CSc2ccccn2)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L16 compound treatment 125720.0 15700.0 0.26 167880.0 44600.0 0.71 0.6866 0.9066 3062709 Maybridge4_000610 CC(C)NC(=O)NCc1c(F)cccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L17 compound treatment 87560.0 -22400.0 -0.37 154640.0 31400.0 0.5 0.092 0.1477 3062710 Maybridge4_000611 Cc1c(C)c(C)c(C(=O)/C=N/N)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L18 compound treatment 100480.0 -9520.0 -0.16 172480.0 49200.0 0.78 0.4438 0.5545 3062711 Maybridge4_000612 CCc1cccc(C(C)C)c1NC(=O)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L19 compound treatment 115400.0 5400.0 0.09 154520.0 31300.0 0.5 0.4156 0.8205 3062712 Maybridge4_000613 COc1ccc(NC(=S)NCCCC2C=NN=C2O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L20 compound treatment 48440.0 -61600.0 -1.02 61560.0 -61700.0 -0.98 -1.4137 -0.9999 3062713 Maybridge4_000614 CC(C)(C)C1=C(C#N)C(C(=C(NC(=O)NC(=O)c2c(F)cccc2Cl)O1)C#N)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L21 compound treatment 111080.0 1080.0 0.02 150520.0 27300.0 0.43 0.3201 0.7354 1309274 Maybridge4_000615 Cc1cc(C)c(C(=O)Nc2ccc(C)c(C)c2)c(CC(C)(C)C(=O)O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L22 compound treatment 108800.0 -1200.0 -0.02 136840.0 13600.0 0.22 0.1393 0.6397 3178823 Maybridge4_000616 OCC(CO)(CO)NC(=S)Nc1cc(Cl)cc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L23 mock treatment 111800.0 1800.0 0.03 141840.0 18600.0 0.3 0.2306 0.774 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 L24 mock treatment 80240.0 -29800.0 -0.49 137360.0 14100.0 0.23 -0.1882 -0.3483 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M01 compound treatment 64360.0 -45600.0 -0.75 138240.0 15000.0 0.24 -0.3637 -0.4601 1443995 Maybridge4_000617 CCCc1ccc(Oc2ccc(NC(=O)C3CC3C(=O)O)cn2)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M02 compound treatment 106760.0 -3240.0 -0.05 143760.0 20500.0 0.33 0.1934 0.5836 2105374 Maybridge4_000618 Oc1ccc(cc1)C(C#N)N2CCN(CC2)C(C#N)c3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M03 compound treatment 29960.0 -80000.0 -1.32 49240.0 -74000.0 -1.18 -1.7683 -0.9984 1235908 Maybridge4_000619 Cc1nc(cs1)c2cc(C#N)c(SCCC(=O)OC(C)(C)C)nc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M04 compound treatment 36480.0 -73500.0 -1.21 44480.0 -78800.0 -1.26 -1.7458 -0.9999 1332220 Maybridge4_000620 COc1ccc(cc1)C(=O)NC2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M05 compound treatment 95480.0 -14500.0 -0.24 132160.0 8920.0 0.14 -0.069 -0.2474 3178824 Maybridge4_000621 CN1C2CCC1CC(C2)NC(=O)Cc3ccccc3F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M06 compound treatment 96040.0 -14000.0 -0.23 146760.0 23500.0 0.37 0.1021 0.2321 3062715 Maybridge4_000622 CCNC(=O)Oc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M07 compound treatment 70120.0 -39900.0 -0.66 104840.0 -18400.0 -0.29 -0.6729 -0.9336 3062716 Maybridge4_000623 CN(C)/C=C/C(=O)c1c(O)cc(C)oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M08 compound treatment 13280.0 -96700.0 -1.6 28800.0 -94400.0 -1.51 -2.1933 -0.9996 1250275 Maybridge4_000624 COc1ccccc1C2CCN(CC2)C(=O)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M09 compound treatment 61440.0 -48600.0 -0.8 87720.0 -35500.0 -0.57 -0.9671 -0.9855 1731106 Maybridge4_000625 COc1ccc(Br)cc1COC(=O)C2c3ccccc3Oc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M10 compound treatment 21160.0 -88800.0 -1.47 39320.0 -83900.0 -1.34 -1.9828 -0.9989 1917572 Maybridge4_000626 CCOc1ccc2[nH]c(SCc3c(F)c(F)c(F)c(F)c3F)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M11 compound treatment 121160.0 11200.0 0.18 169480.0 46200.0 0.74 0.6514 0.8574 1003070 Maybridge4_000627 Cc1ccc(cc1)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M12 compound treatment 143360.0 33400.0 0.55 159000.0 35800.0 0.57 0.7924 0.9999 3062717 Maybridge4_000628 CSc1nc2c(=S)[nH]c(=S)[nH]c2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M13 compound treatment 144520.0 34500.0 0.57 168680.0 45400.0 0.72 0.915 0.9929 3062718 Maybridge4_000629 O/N=C(/C(=N/O)/c1ccccc1)\c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M14 compound treatment 112120.0 2120.0 0.03 167600.0 44400.0 0.71 0.5247 0.7412 1781230 Maybridge4_000630 CCOC(=O)CNc1n[nH]c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M15 compound treatment 42880.0 -67100.0 -1.11 139000.0 15800.0 0.25 -0.6058 -0.5332 3062719 Maybridge4_000631 Cc1cc(C)nc(S/C=C/C(=O)c2ccc(Cl)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M16 compound treatment 77680.0 -32300.0 -0.53 164200.0 41000.0 0.65 0.0844 0.1001 1718236 Maybridge4_000632 Cn1c(=O)cc(N2CCOCC2)c3c(=O)n(c4ccccc4)c(=O)n(c5ccccc5)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M17 compound treatment 92200.0 -17800.0 -0.29 166240.0 43000.0 0.69 0.2769 0.3712 3178825 Maybridge4_000633 CC(=O)NC1=NN(C(N1C(=O)C)c2cccc3ccccc23)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M18 compound treatment 108080.0 -1920.0 -0.03 168800.0 45600.0 0.73 0.4911 0.6756 1286292 Maybridge4_000634 O=C(NC(C(=O)c1ccccc1)n2cnccc2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M19 compound treatment 8080.0 -102000.0 -1.68 13800.0 -109000.0 -1.74 -2.4231 -0.9998 1171458 Maybridge4_000635 OC(COCc1ccccc1)Cn2c3ccccc3c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M20 compound treatment 109880.0 -123.0 0.0 168320.0 45100.0 0.72 0.5067 0.7051 3062720 Maybridge4_000636 C/S(=N\S(=O)(=O)c1ccc(C)cc1)/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M21 compound treatment 97600.0 -12400.0 -0.2 139080.0 15800.0 0.25 0.0338 0.1039 1311339 Maybridge4_000637 O=C(C(C#N)c1nc2ccccc2[nH]1)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M22 compound treatment 122480.0 12500.0 0.21 149520.0 26300.0 0.42 0.4419 0.9466 1645478 Maybridge4_000638 COC(=O)C1C([C@H]2c3ccccc3[C@@H]1c4ccccc24)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M23 mock treatment 103880.0 -6120.0 -0.1 164240.0 41000.0 0.65 0.3906 0.5907 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 M24 mock treatment 97480.0 -12500.0 -0.21 126320.0 3080.0 0.05 -0.1114 -0.5244 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N01 compound treatment 74160.0 -35800.0 -0.59 142400.0 19200.0 0.31 -0.2024 -0.304 1273203 Maybridge4_000639 CN(C)CC1(CC(=O)O)CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N02 compound treatment 78040.0 -32000.0 -0.53 156120.0 32900.0 0.52 -0.0025 -0.0033 3178826 Maybridge4_000640 NN/C(=N/S(=O)(=O)c1ccccc1)/N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N03 compound treatment 5360.0 -105000.0 -1.73 13280.0 -110000.0 -1.75 -2.4607 -1.0 3062722 Maybridge4_000641 O=C1NC(=O)C(=C/C=C/c2ccccc2)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N04 compound treatment 94120.0 -15900.0 -0.26 159280.0 36000.0 0.57 0.2208 0.3497 1678177 Maybridge4_000642 COc1cccc(OC)c1C(=O)Nc2ccccc2NC(=O)c3c(OC)cccc3OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N05 compound treatment 103040.0 -6960.0 -0.11 164040.0 40800.0 0.65 0.3786 0.5733 1073885 Maybridge4_000643 CCOc1ccc(CCC(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N06 compound treatment 93760.0 -16200.0 -0.27 157200.0 34000.0 0.54 0.1932 0.3198 3178827 Maybridge4_000644 CS/C(=N\S(=O)(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)/N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N07 compound treatment 82040.0 -28000.0 -0.46 155760.0 32500.0 0.52 0.0401 0.0578 3062723 Maybridge4_000645 Oc1noc(O)c1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N08 compound treatment 85360.0 -24600.0 -0.41 166800.0 43600.0 0.69 0.2033 0.2527 3062724 Maybridge4_000646 NC(=S)NC1CC2CC1C=C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N09 compound treatment 103560.0 -6440.0 -0.11 159880.0 36600.0 0.58 0.3378 0.569 3178828 Maybridge4_000647 CCNc1cc(N)[n+](CC)c2[nH]nc(N)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N10 compound treatment 69080.0 -40900.0 -0.68 106320.0 -16900.0 -0.27 -0.6683 -0.9189 1512370 Maybridge4_000648 COc1ccc(cc1CN2CCOCC2)c3cc(c4ccccc4)c(nn3)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N11 compound treatment 129000.0 19000.0 0.31 159040.0 35800.0 0.57 0.6252 0.9603 1288584 Maybridge4_000649 S=C(NC1CC2CC1C=C2)N(CCC#N)Cc3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N12 compound treatment 151160.0 41200.0 0.68 162000.0 38800.0 0.62 0.9173 0.9989 3178829 Maybridge4_000650 CC(=O)NCc1c(F)cccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N13 compound treatment 92680.0 -17300.0 -0.29 132200.0 8960.0 0.14 -0.1012 -0.3166 1566685 Maybridge4_000651 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)Nc2cccc(SC)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N14 compound treatment 88880.0 -21100.0 -0.35 154440.0 31200.0 0.5 0.1051 0.1731 3062725 Maybridge4_000652 Fc1cccc(Cl)c1CSc2ccccc2C3=NCCCN3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N15 compound treatment 46880.0 -63100.0 -1.04 143560.0 20300.0 0.32 -0.5078 -0.4653 3178830 Maybridge4_000653 Cc1c(C)c(C)c(CSC2=NCCS2)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N16 compound treatment 60880.0 -49100.0 -0.81 169720.0 46500.0 0.74 -0.0495 -0.0451 3062726 Maybridge4_000654 Clc1cc(C[n+]2ccccc2)c3OCOCc3c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N17 compound treatment 85800.0 -24200.0 -0.4 176240.0 53000.0 0.84 0.3148 0.3369 3062727 Maybridge4_000655 Cn1c(S)nnc1CC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N18 compound treatment 89640.0 -20400.0 -0.34 166800.0 43600.0 0.69 0.2533 0.3283 3178831 Maybridge4_000656 CC1CC(C)CN(C1)S(=O)(=O)c2c(C)c(C)c(C)c(C)c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N19 compound treatment 103520.0 -6480.0 -0.11 163400.0 40200.0 0.64 0.377 0.5808 3178832 Maybridge4_000657 N#Cc1cccc(CSc2nnc(SCc3cccc(C#N)c3)s2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N20 compound treatment 16160.0 -93800.0 -1.55 47440.0 -75800.0 -1.21 -1.9496 -0.9924 3062728 Maybridge4_000658 CC1(C)ON(C(=N1)NS(=O)(=O)c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N21 compound treatment 96440.0 -13600.0 -0.22 149400.0 26200.0 0.42 0.1366 0.2885 3178833 Maybridge4_000659 CC1N=C(SCC#N)N2C(C)N=C(SCC#N)N12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N22 compound treatment 115840.0 5840.0 0.1 143840.0 20600.0 0.33 0.3003 0.8776 1490971 Maybridge4_000660 Nc1ccccc1C(=O)NCc2c(F)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N23 mock treatment 94320.0 -15700.0 -0.26 131560.0 8320.0 0.13 -0.0893 -0.3068 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 N24 mock treatment 101680.0 -8320.0 -0.14 119240.0 -4000.0 -0.06 -0.1422 -0.939 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O01 compound treatment 63240.0 -46800.0 -0.77 103280.0 -20000.0 -0.32 -0.7708 -0.9232 3178834 Maybridge4_000661 COc1ccccc1C2OC(=O)C[C@H]2C(=O)Oc3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O02 compound treatment 55040.0 -55000.0 -0.91 86120.0 -37100.0 -0.59 -1.0599 -0.9785 3178835 Maybridge4_000662 FC(F)(F)c1cc(NC(=S)NCCN2CCNC2=O)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O03 compound treatment 93040.0 -17000.0 -0.28 177800.0 54600.0 0.87 0.4169 0.4564 1251917 Maybridge4_000663 Cc1ccc(OC(C)(C)C(=O)Nc2ccc(Oc3ccc(F)cc3F)nc2)c4CCCc41 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O04 compound treatment 55600.0 -54400.0 -0.9 130440.0 7200.0 0.11 -0.5538 -0.6117 3178836 Maybridge4_000664 Cc1ccccc1NC2=NCC(C)(C)S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O05 compound treatment 67720.0 -42300.0 -0.7 163280.0 40000.0 0.64 -0.0422 -0.0447 1342095 Maybridge4_000665 NC(=O)C1c2ccccc2Oc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O06 compound treatment 95520.0 -14500.0 -0.24 170040.0 46800.0 0.75 0.3584 0.4576 3178916 Maybridge4_000666 CC(C)(C)NC(=O)Oc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O07 compound treatment 58080.0 -51900.0 -0.86 148880.0 25600.0 0.41 -0.3171 -0.3339 1101019 Maybridge4_000667 CC(C)(C)c1cc(c2oc(cc(=O)c2c1)C(=O)O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O08 compound treatment 92240.0 -17800.0 -0.29 166920.0 43700.0 0.7 0.285 0.3772 1485865 Maybridge4_000668 Clc1ccc(OC2CN(C2)C(=O)NCC=C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O09 compound treatment 74840.0 -35200.0 -0.58 122400.0 -838.0 -0.01 -0.4199 -0.7232 3178917 Maybridge4_000669 O=C(Oc1ccc2ccccc2c1)C3c4ccccc4Oc5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O10 compound treatment 78440.0 -31600.0 -0.52 148520.0 25300.0 0.4 -0.0835 -0.1267 1074403 Maybridge4_000670 C1CCC(CC1)Nc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O11 compound treatment 115400.0 5400.0 0.09 166440.0 43200.0 0.69 0.5499 0.792 1171317 Maybridge4_000671 COc1cc(OC)cc(c1)C(C)(C)OC(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O12 compound treatment 148120.0 38100.0 0.63 162800.0 39600.0 0.63 0.8908 1.0 1302360 Maybridge4_000672 OC(=O)Cc1cncc(Br)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O13 compound treatment 110280.0 278.0 0.0 131440.0 8200.0 0.13 0.0957 0.7314 3063089 Maybridge4_000673 C/C(=N\O)/c1c(O)c2ccccc2n(C)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O14 compound treatment 118120.0 8120.0 0.13 161560.0 38300.0 0.61 0.5267 0.8422 1915396 Maybridge4_000674 CC1(C)OC2C(CO)OC(C2O1)n3cnc4c(=O)[nH]cnc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O15 compound treatment 89520.0 -20500.0 -0.34 155920.0 32700.0 0.52 0.1293 0.2081 1665055 Maybridge4_000675 CC(=O)OCc1ccccc1Sc2ccccc2C(=O)NCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O16 compound treatment 88480.0 -21500.0 -0.36 176160.0 52900.0 0.84 0.3452 0.3772 3063091 Maybridge4_000676 CN1C(=O)/C(=C\NCc2ccccc2)/C(=O)c3c1n(C)c(=O)n(C)c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O17 compound treatment 81360.0 -28600.0 -0.47 172320.0 49100.0 0.78 0.2188 0.2394 3178918 Maybridge4_000677 COC(=O)c1cc(=O)nc2O[C@@H]3C(O)[C@@H](CO)OC3n21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O18 compound treatment 76880.0 -33100.0 -0.55 164800.0 41600.0 0.66 0.0818 0.0952 1458724 Maybridge4_000678 OC(=O)CCC1(CC2CC3CC(O)(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O19 compound treatment 10040.0 -100000.0 -1.65 51920.0 -71300.0 -1.14 -1.9706 -0.9834 3178919 Maybridge4_000679 CCn1c2ccc(Cl)cc2c3cc(Cl)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O20 compound treatment 85400.0 -24600.0 -0.41 139680.0 16400.0 0.26 -0.1019 -0.2107 1547077 Maybridge4_000680 Cc1ccc(cc1)S(=O)(=O)N=S(Cc2ccccc2)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O21 compound treatment 97480.0 -12500.0 -0.21 143680.0 20400.0 0.33 0.0842 0.2183 3063093 Maybridge4_000681 CC(C)(C)c1ccc(=O)[nH]n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O22 compound treatment 67160.0 -42800.0 -0.71 83680.0 -39600.0 -0.63 -0.9459 -0.9984 3178920 Maybridge4_000682 Brc1ccc(NC(=O)N2NC(=O)[C@H]([C@@H]2c3ccccc3)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O23 mock treatment 88120.0 -21900.0 -0.36 130520.0 7280.0 0.12 -0.1733 -0.4569 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 O24 mock treatment 92840.0 -17200.0 -0.28 132200.0 8960.0 0.14 -0.0993 -0.313 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P01 compound treatment 97800.0 -12200.0 -0.2 73480.0 -49800.0 -0.79 -0.7032 -0.8594 3063094 Maybridge4_000683 COC(=O)/C=C/c1cn(C2OCC(CO)C2O)c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P02 compound treatment 107640.0 -2360.0 -0.04 128000.0 4760.0 0.08 0.0261 0.3058 3178921 Maybridge4_000684 NNC(=O)CS(=O)Cc1cccc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P03 compound treatment 12400.0 -97600.0 -1.61 27720.0 -95500.0 -1.52 -2.2158 -0.9996 3063095 Maybridge4_000685 O=C1NC(=O)C(=Cc2cccc3ccccc23)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P04 compound treatment 19360.0 -90600.0 -1.5 69960.0 -53300.0 -0.85 -1.6585 -0.964 3178922 Maybridge4_000686 O/N=C/c1ccc(o1)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P05 compound treatment 3520.0 -106000.0 -1.76 7880.0 -115000.0 -1.84 -2.543 -0.9997 1352669 Maybridge4_000687 COc1cccc(NC(=S)NC(Cc2ccccc2)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P06 compound treatment 46240.0 -63800.0 -1.05 107760.0 -15500.0 -0.25 -0.9187 -0.8498 1145524 Maybridge4_000688 Clc1ccc(Cl)c(NC(=S)Nc2ccc(nc2)N3CCOCC3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P07 compound treatment 37800.0 -72200.0 -1.19 102880.0 -20400.0 -0.32 -1.0722 -0.868 1152510 Maybridge4_000689 COc1ccc(CSC2=C(C#N)C(=O)NC3(CCCCC3)S2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P08 compound treatment 72360.0 -37600.0 -0.62 158120.0 34900.0 0.56 -0.0462 -0.0555 3063149 Maybridge4_000690 Clc1ccccc1NC(=O)CC2SC(=NC2=O)NC3CC4CC3C=C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P09 compound treatment 9240.0 -101000.0 -1.66 54800.0 -68400.0 -1.09 -1.9474 -0.9791 3178923 Maybridge4_000691 CCNc1cc(N)[n+](CC)c2[nH]nc(/N=C/c3cc(Cl)cc(Cl)c3O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P10 compound treatment 78520.0 -31500.0 -0.52 154720.0 31500.0 0.5 -0.0127 -0.0175 3063150 Maybridge4_000692 N/C(=N\O)/CN1CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P11 compound treatment 80600.0 -29400.0 -0.49 155080.0 31800.0 0.51 0.0157 0.0223 1138088 Maybridge4_000693 S=C(NC1CC2CC1C=C2)N(CCC#N)CC3CCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P12 compound treatment 66360.0 -43600.0 -0.72 95520.0 -27700.0 -0.44 -0.8218 -0.9724 3063152 Maybridge4_000694 Fc1cccc(Cl)c1CSC2=NCCN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P13 compound treatment 79920.0 -30100.0 -0.5 150480.0 27200.0 0.43 -0.0441 -0.0669 1637772 Maybridge4_000695 Cc1onc(c1C(=O)N2CCCN3C2c4ccccc4C3=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P14 compound treatment 59680.0 -50300.0 -0.83 157120.0 33900.0 0.54 -0.2055 -0.2074 3063153 Maybridge4_000696 Nn1c(nc2ccccc2c1=O)C(=O)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P15 compound treatment 58600.0 -51400.0 -0.85 109640.0 -13600.0 -0.22 -0.7532 -0.8601 1322891 Maybridge4_000697 CCOC(=O)CCc1ccc(OCc2c(C)c(C)c(C)c(C)c2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P16 compound treatment 27160.0 -82800.0 -1.37 71600.0 -51600.0 -0.82 -1.5489 -0.9705 3063154 Maybridge4_000698 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NCCCN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P17 compound treatment 20600.0 -89400.0 -1.48 54240.0 -69000.0 -1.1 -1.8212 -0.9895 1180785 Maybridge4_000699 Cc1c(C)c(C)c(C(=O)CCc2cccc(NC(=O)C3CCC3)c2)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P18 compound treatment 61200.0 -48800.0 -0.81 152080.0 28800.0 0.46 -0.2446 -0.2637 3063155 Maybridge4_000700 Cc1c(C)c(C)c(c(C)c1C)S(=O)(=O)NC(=N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P19 compound treatment 49760.0 -60200.0 -0.99 96320.0 -26900.0 -0.43 -1.0065 -0.9294 3178924 Maybridge4_000701 N/C(=N\O)/Cc1nc(cs1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P20 compound treatment 44760.0 -65200.0 -1.08 118360.0 -4880.0 -0.08 -0.8165 -0.7562 3063157 Maybridge4_000702 Cc1nnsc1C(=O)NC(=O)Nc2cc(Cl)cc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P21 compound treatment 20640.0 -89400.0 -1.48 22360.0 -101000.0 -1.61 -2.18 -0.9991 3178925 Maybridge4_000703 CC1(C)NN(C(=N1)S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P22 compound treatment 74680.0 -35300.0 -0.58 68480.0 -54800.0 -0.87 -1.0294 -0.9808 3063158 Maybridge4_000704 CSc1nc(nc(SC)c1Cl)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P23 mock treatment 102040.0 -7960.0 -0.13 84560.0 -38700.0 -0.62 -0.5288 -0.839 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2050 P24 mock treatment 103600.0 -6400.0 -0.11 71360.0 -51900.0 -0.83 -0.6594 -0.7911 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A01 compound treatment 39440.0 -30200.0 -0.5 54120.0 -17000.0 -0.27 -0.5444 -0.9592 3063827 Maybridge4_001761 Cc1noc(C)c1S(=O)(=O)NCC2COc3ccccc3O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A02 compound treatment 20760.0 -48900.0 -0.81 17600.0 -53600.0 -0.85 -1.1741 -0.9996 3179242 Maybridge4_001762 COc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A03 compound treatment 80000.0 10400.0 0.17 45600.0 -25600.0 -0.41 -0.167 -0.3781 3063828 Maybridge4_001763 COc1ccc(cc1)c2nnsc2N3C(=O)c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A04 compound treatment 72640.0 3000.0 0.05 40720.0 -30400.0 -0.49 -0.3079 -0.6316 3179243 Maybridge4_001764 CCn1c(Cn2nnc3ccccc23)nnc1SCC(=O)c4ccc(Br)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A05 compound treatment 40720.0 -28900.0 -0.48 18240.0 -52900.0 -0.84 -0.9339 -0.9637 3179244 Maybridge4_001765 C1Cc2cc(ccc2O1)C3Nc4ccccc4-c5cccn35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A06 compound treatment 198800.0 129000.0 2.13 30800.0 -40400.0 -0.64 1.0529 0.4728 3063829 Maybridge4_001766 S=C(Nc1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A07 compound treatment 144320.0 74700.0 1.23 31200.0 -40000.0 -0.64 0.4215 0.3038 3179245 Maybridge4_001767 O=S(=O)(NCc1ccco1)c2ccc(Oc3c(C#N)cccc3C#N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A08 compound treatment 112400.0 42800.0 0.71 29520.0 -41600.0 -0.66 0.0299 0.0309 3063830 Maybridge4_001768 Nc1nc(Sc2nnc(c3ccncc3)n2c4ccccc4)ncc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A09 compound treatment 153080.0 83400.0 1.38 37880.0 -33300.0 -0.53 0.599 0.4058 3179246 Maybridge4_001769 Clc1ccc(COC(=O)c2ccc3ccccc3n2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A10 compound treatment 110320.0 40700.0 0.67 31280.0 -39900.0 -0.64 0.0255 0.0276 3063831 Maybridge4_001770 O=C(CSc1nnc(o1)c2ccncc2)NC(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A11 compound treatment 197200.0 128000.0 2.11 68160.0 -2990.0 -0.05 1.4552 0.6909 1526124 Maybridge4_001771 S=c1[nH]nc(c2ccncc2)n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A12 compound treatment 154960.0 85300.0 1.41 50440.0 -20700.0 -0.33 0.7625 0.5271 3179247 Maybridge4_001772 S=c1[nH]c(=S)c2cnc(nc2[nH]1)N3CCc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A13 compound treatment 211960.0 142000.0 2.35 71680.0 530.0 0.01 1.6672 0.7096 3063832 Maybridge4_001773 Cc1cc(C)c2c(n1)sc3c(=O)n(/N=C/c4ccccc4)cnc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A14 compound treatment 258840.0 189000.0 3.12 72040.0 890.0 0.01 2.2185 0.7103 3179248 Maybridge4_001774 Fc1ccc(Cn2nc3sc4ccccc4n3c(=O)c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A15 compound treatment 126760.0 57100.0 0.94 53600.0 -17600.0 -0.28 0.4689 0.4768 3063833 Maybridge4_001775 Clc1ccccc1Cn2nnc3c(=S)[nH]cnc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A16 compound treatment 132600.0 63000.0 1.04 36320.0 -34800.0 -0.56 0.3424 0.2906 3179249 Maybridge4_001776 CCOC(=O)c1c(C)c(C)sc1NC(=S)Nc2cc(C)nn2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A17 compound treatment 120880.0 51200.0 0.85 36360.0 -34800.0 -0.55 0.206 0.2037 3063834 Maybridge4_001777 CCOC(=O)c1nnn2c1nc(N(CC)CC)c3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A18 compound treatment 186680.0 117000.0 1.93 31000.0 -40200.0 -0.64 0.9137 0.4489 3179250 Maybridge4_001778 Cc1cc(C)c2c(n1)sc3c(=O)n(NC(=O)Nc4ccccc4)c(C)nc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A19 compound treatment 141360.0 71700.0 1.18 40280.0 -30900.0 -0.49 0.4892 0.3816 3063835 Maybridge4_001779 CCOC(=O)c1nn(c2ccccc2)c3nc(=O)c(C#N)c(c4ccccc4)n13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A20 compound treatment 90120.0 20500.0 0.34 44800.0 -26400.0 -0.42 -0.0579 -0.1074 3179251 Maybridge4_001780 O=C(Cn1c(=O)n(c2ccccc2)c(=O)c3cc(sc13)c4ccccc4)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A21 compound treatment 74680.0 5040.0 0.08 54040.0 -17100.0 -0.27 -0.134 -0.4699 3179252 Maybridge4_001781 COc1ccc(cc1)n2ncc(NC(=O)NCc3ccccn3)c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A22 compound treatment 60520.0 -9120.0 -0.15 36480.0 -34700.0 -0.55 -0.4972 -0.8681 3063836 Maybridge4_001782 COc1ccc(/C=C/2\N=C(N(/N=C/c3cccnc3)C2=O)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A23 mock treatment 67320.0 -2320.0 -0.04 52240.0 -18900.0 -0.3 -0.2402 -0.7906 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 A24 mock treatment 54240.0 -15400.0 -0.25 66200.0 -4950.0 -0.08 -0.2355 -0.8849 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B01 compound treatment 136160.0 66500.0 1.1 47760.0 -23400.0 -0.37 0.5129 0.4422 3179253 Maybridge4_001783 OC(=O)CSc1nnc([nH]1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B02 compound treatment 143240.0 73600.0 1.21 79120.0 7970.0 0.13 0.9489 0.7768 3063837 Maybridge4_001784 O=c1oc2=C(c3ccccc3)S(=O)(=O)C(=c2o1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B03 compound treatment 128880.0 59200.0 0.98 48000.0 -23200.0 -0.37 0.4306 0.412 3179254 Maybridge4_001785 Cc1cc(C)c2c3NC(=O)CN(C(=O)c3sc2n1)c4ccccc4C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B04 compound treatment 15880.0 -53800.0 -0.89 4480.0 -66700.0 -1.06 -1.3789 -0.996 1701942 Maybridge4_001786 COc1ccc(cc1)N2C(=O)Cc3ccc(OC)cc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B05 compound treatment 145080.0 75400.0 1.25 102520.0 31400.0 0.5 1.2341 0.9197 3179255 Maybridge4_001787 Clc1ccc(cc1)n2c(=N)c3cnc(nc3[nH]c2=O)N4CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B06 compound treatment 164440.0 94800.0 1.56 61680.0 -9470.0 -0.15 0.9998 0.636 1588538 Maybridge4_001788 Cc1oc2cc(O)ccc2c(=O)c1Oc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B07 compound treatment 65160.0 -4480.0 -0.07 21400.0 -49800.0 -0.79 -0.613 -0.7697 3179256 Maybridge4_001789 COc1ccc(cc1)n/2c(cs\c2=N/Cc3cccnc3)c4cccc(OC)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B08 compound treatment 158800.0 89200.0 1.47 52160.0 -19000.0 -0.3 0.8267 0.5502 3179257 Maybridge4_001790 O=C(c1ccccc1)c2cccc(NC=C3C(=O)NC(=O)NC3=O)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B09 compound treatment 12200.0 -57400.0 -0.95 3640.0 -67500.0 -1.08 -1.4313 -0.998 1289329 Maybridge4_001791 O=C1C(=C(c2ccccc2)S(=O)(=O)c3ccccc13)Cc4ccc(cc4)c5nnn[nH]5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B10 compound treatment 173120.0 103000.0 1.71 44680.0 -26500.0 -0.42 0.9095 0.5169 1270319 Maybridge4_001792 O=C(c1ccccn1)c2ccc3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B11 compound treatment 23200.0 -46400.0 -0.77 6080.0 -65100.0 -1.04 -1.2754 -0.9889 1356935 Maybridge4_001793 C1C2CC3CC1CC(C2)(C3)c4cn5ccccc5n4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B12 compound treatment 81360.0 11700.0 0.19 51400.0 -19800.0 -0.31 -0.0858 -0.2321 1489551 Maybridge4_001794 Cc1cc(c(Cl)cc1Cl)S(=O)(=O)N2CCC(CC2)NC(=O)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B13 compound treatment 206440.0 137000.0 2.26 113640.0 42500.0 0.68 2.0757 0.8804 3063861 Maybridge4_001795 CC(=O)O[C@@H]1[C@H]2CO[C@H](O2)[C@H](OC(=O)C)[C@H]1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B14 compound treatment 194320.0 125000.0 2.06 82560.0 11400.0 0.18 1.5839 0.7666 1649672 Maybridge4_001796 COc1cc(C(=O)CCC(=O)O)c(OC)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B15 compound treatment 183920.0 114000.0 1.89 57320.0 -13800.0 -0.22 1.1781 0.6203 1471910 Maybridge4_001797 Cc1ccc(NC(=O)N2C(=O)C3(OCCO3)c4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B16 compound treatment 198200.0 129000.0 2.12 33960.0 -37200.0 -0.59 1.0815 0.4908 1205899 Maybridge4_001798 CCOC(=O)C1=C(C)N(C)C(=O)N(C)C1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B17 compound treatment 188000.0 118000.0 1.95 47680.0 -23500.0 -0.37 1.117 0.5615 3063863 Maybridge4_001799 CC(=O)Nc1ccc2oc(cc(=O)c2c1)c3ccc(C#N)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B18 compound treatment 41440.0 -28200.0 -0.47 18000.0 -53200.0 -0.85 -0.9282 -0.9602 3179258 Maybridge4_001800 Cc1c(sc2nc(C)cc(C)c12)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B19 compound treatment 201880.0 132000.0 2.18 41920.0 -29200.0 -0.47 1.2141 0.5439 3063864 Maybridge4_001801 CC(O)/C=C\c1cc[n+](C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B20 compound treatment 67800.0 -1840.0 -0.03 13680.0 -57500.0 -0.92 -0.6692 -0.7301 3179259 Maybridge4_001802 O=C(NC(=S)NC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B21 compound treatment 142520.0 72900.0 1.2 49960.0 -21200.0 -0.34 0.6119 0.4897 1176828 Maybridge4_001803 COC(=O)C1C(C(C(=O)OC)S(=O)(=O)CS1(=O)=O)c2ccc(OC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B22 compound treatment 132680.0 63000.0 1.04 50600.0 -20600.0 -0.33 0.5042 0.4622 1288189 Maybridge4_001804 COC(=O)C1=C(C)NC(=C(C1)C(=O)OC)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B23 mock treatment 130480.0 60800.0 1.0 43240.0 -27900.0 -0.44 0.3956 0.3602 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 B24 mock treatment 114400.0 44800.0 0.74 44880.0 -26300.0 -0.42 0.2264 0.2666 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C01 compound treatment 34960.0 -34700.0 -0.57 21600.0 -49600.0 -0.79 -0.9632 -0.9875 3179260 Maybridge4_001805 O=S(=O)(NCC1COc2ccccc2O1)c3ccc(s3)S(=O)(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C02 compound treatment 8240.0 -61400.0 -1.01 3760.0 -67400.0 -1.07 -1.4762 -0.9996 3063865 Maybridge4_001806 Fc1ccc(cc1)C2C3CCc4ccccc4C3=NN2C(=O)c5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C03 compound treatment 113520.0 43900.0 0.72 38680.0 -32500.0 -0.52 0.1463 0.1643 3179353 Maybridge4_001807 COc1ccc(cc1OC)C(=O)NCc2ccc(C#N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C04 compound treatment 52120.0 -17500.0 -0.29 11480.0 -59700.0 -0.95 -0.877 -0.8822 3063866 Maybridge4_001808 O=C(Oc1c(c2ccccc2)c(=O)n3CCc4cccc1c43)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C05 compound treatment 83680.0 14000.0 0.23 52720.0 -18400.0 -0.29 -0.0438 -0.1171 3179354 Maybridge4_001809 FC(F)(F)c1ccc(cc1)c2nnc(SCc3ccncc3)n2Cc4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C06 compound treatment 55520.0 -14100.0 -0.23 20160.0 -51000.0 -0.81 -0.7395 -0.8746 3063867 Maybridge4_001810 CCOC(=O)c1nnn2c1nc(Sc3nc4ccccc4o3)c5ccccc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C07 compound treatment 95760.0 26100.0 0.43 44120.0 -27000.0 -0.43 3.0E-4 4.0E-4 3179355 Maybridge4_001811 COc1cccc(Cc2nnc(o2)c3c(C)onc3c4ccccc4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C08 compound treatment 10920.0 -58700.0 -0.97 4160.0 -67000.0 -1.07 -1.4404 -0.9988 3179356 Maybridge4_001812 C=CCn1c(=S)sc2c(Sc3nnc(o3)c4ccco4)ncnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C09 compound treatment 135880.0 66200.0 1.09 38200.0 -33000.0 -0.53 0.4018 0.3313 3063868 Maybridge4_001813 Clc1ccc(Cn2c(=O)n(Cc3ccc(Cl)cc3)c4ccccc4c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C10 compound treatment 150840.0 81200.0 1.34 39760.0 -31400.0 -0.5 0.594 0.4152 3179357 Maybridge4_001814 Nc1nc(SCC(=O)NC(=O)Nc2ccccc2)ncc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C11 compound treatment 25520.0 -44100.0 -0.73 5440.0 -65700.0 -1.05 -1.2555 -0.9842 2099392 Maybridge4_001815 Cc1nc2ccc(F)cc2c3N(CCc31)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C12 compound treatment 63480.0 -6160.0 -0.1 48880.0 -22300.0 -0.35 -0.3229 -0.8745 3179358 Maybridge4_001816 C=CCSc1ncc2c(=S)[nH]c(=S)[nH]c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C13 compound treatment 91960.0 22300.0 0.37 27000.0 -44200.0 -0.7 -0.237 -0.2984 3179359 Maybridge4_001817 Cc1cc(C)c2c(n1)sc3c(SCC(=O)c4ccc(Br)cc4)ncnc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C14 compound treatment 162680.0 93000.0 1.54 96640.0 25500.0 0.41 1.3733 0.8644 3063869 Maybridge4_001818 C=CCn1nc2sc3ccccc3n2c(=O)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C15 compound treatment 142160.0 72500.0 1.2 50240.0 -20900.0 -0.33 0.6108 0.4916 3179360 Maybridge4_001819 COc1ccc(Nc2ncnc3n(Cc4ccccc4Cl)nnc23)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C16 compound treatment 120680.0 51000.0 0.84 20760.0 -50400.0 -0.8 0.0279 0.0239 3063871 Maybridge4_001820 CCOC(=O)c1c(C)c(C)sc1NC(=S)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C17 compound treatment 101880.0 32200.0 0.53 30240.0 -40900.0 -0.65 -0.0847 -0.1007 3179361 Maybridge4_001821 CCOC(=O)c1nnn2c1nc(N3CCN(CC3)c4ccccc4)c5ccccc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C18 compound treatment 11080.0 -58600.0 -0.97 4160.0 -67000.0 -1.07 -1.4385 -0.9988 3063872 Maybridge4_001822 Cc1cc(C)c2c(=O)n(sc2n1)C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C19 compound treatment 53560.0 -16100.0 -0.27 16960.0 -54200.0 -0.86 -0.7984 -0.8836 3179362 Maybridge4_001823 COc1ccc(cc1)C2C(=C(N)N3CCc4cc(OC)c(OC)cc4C3=C2C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C20 compound treatment 136120.0 66500.0 1.1 31920.0 -39200.0 -0.63 0.3339 0.2643 3063873 Maybridge4_001824 CNC(=O)NC(=O)Cn1cnc2sc(cc2c1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C21 compound treatment 104800.0 35200.0 0.58 39920.0 -31200.0 -0.5 0.0584 0.0764 3179363 Maybridge4_001825 COc1cc2CCN3C(N(N=C3C(=O)c4cccs4)c5ccccc5)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C22 compound treatment 27560.0 -42100.0 -0.69 6240.0 -64900.0 -1.03 -1.2227 -0.9812 3063874 Maybridge4_001826 Fc1ccc(/C=N/N2C(=O)/C(=C/c3ccco3)/N=C2c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C23 mock treatment 110240.0 40600.0 0.67 50800.0 -20400.0 -0.32 0.2446 0.3285 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 C24 mock treatment 99960.0 30300.0 0.5 63680.0 -7470.0 -0.12 0.2697 0.5243 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D01 compound treatment 47480.0 -22200.0 -0.37 17400.0 -53800.0 -0.86 -0.8644 -0.928 3179364 Maybridge4_001827 CCOC(=O)CSc1nc(Nc2ccc(OC)cc2)c3cnc(nc3n1)N(CC)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D02 compound treatment 116400.0 46800.0 0.77 41720.0 -29400.0 -0.47 0.2141 0.2371 1016783 Maybridge4_001828 CSc1ncnc2[nH]cnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D03 compound treatment 52280.0 -17400.0 -0.29 23040.0 -48100.0 -0.77 -0.7448 -0.9099 3179365 Maybridge4_001829 CCOC(=O)CSc1nc(Nc2ccccc2)c3cnc(nc3n1)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D04 compound treatment 144040.0 74400.0 1.23 116800.0 45700.0 0.73 1.3829 0.9688 3063875 Maybridge4_001830 CCn1c(C)[n+](CC)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D05 compound treatment 28880.0 -40800.0 -0.67 10320.0 -60800.0 -0.97 -1.1613 -0.9841 3179366 Maybridge4_001831 Nc1c(C#N)c(cc2c3ccccc3oc(=O)c12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D06 compound treatment 100640.0 31000.0 0.51 48560.0 -22600.0 -0.36 0.1073 0.1714 1156367 Maybridge4_001832 CC(=O)Oc1ccc2c(=O)c(Oc3ccc(Cl)cc3)c(C)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D07 compound treatment 150800.0 81200.0 1.34 68600.0 -2550.0 -0.04 0.9186 0.6853 3179367 Maybridge4_001833 CC(/C=N/N1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D08 compound treatment 79200.0 9560.0 0.16 46040.0 -25100.0 -0.4 -0.1714 -0.3984 3063876 Maybridge4_001834 COC(=O)c1sc(=S)sc1C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D09 compound treatment 47320.0 -22300.0 -0.37 31240.0 -39900.0 -0.64 -0.7103 -0.9663 1027030 Maybridge4_001835 Clc1ccc2OC(CC(=O)c2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D10 compound treatment 146360.0 76700.0 1.27 118960.0 47800.0 0.76 1.4343 0.9704 1567173 Maybridge4_001836 C=CCN1C(=O)NC2(CCCCC2)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D11 compound treatment 104240.0 34600.0 0.57 36840.0 -34300.0 -0.55 0.0172 0.0217 1014811 Maybridge4_001837 O=C(N(C(=O)c1ccccc1)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D12 compound treatment 164520.0 94900.0 1.57 137640.0 66500.0 1.06 1.8568 0.9819 1422860 Maybridge4_001838 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D13 compound treatment 156080.0 86400.0 1.43 144800.0 73700.0 1.17 1.839 0.9953 3063327 Maybridge4_001839 CCOc1ccc2nc(S/C=C/C(=O)c3ccc(Cl)cc3)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D14 compound treatment 154520.0 84900.0 1.4 77400.0 6250.0 0.1 1.0612 0.7555 1403045 Maybridge4_001840 COc1cc(c(OC)cc1C)c2cc(OC)c(C)cc2OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D15 compound treatment 155480.0 85800.0 1.42 101560.0 30400.0 0.48 1.3447 0.8979 1267535 Maybridge4_001841 OC(=O)C(Sc1ccccc1C(=O)O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D16 compound treatment 143560.0 73900.0 1.22 80120.0 8970.0 0.14 0.9639 0.7846 3063328 Maybridge4_001842 CC(C)(C)[C@H]1COC(=N1)CC2=N[C@H](CO2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D17 compound treatment 147720.0 78100.0 1.29 50200.0 -21000.0 -0.33 0.6753 0.5072 1035033 Maybridge4_001843 O=C(C1=NNCC1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D18 compound treatment 157360.0 87700.0 1.45 67160.0 -3990.0 -0.06 0.9789 0.6754 1414609 Maybridge4_001844 CC(=O)Oc1ccc2c(=O)c(c3nc4ccccc4n3C)c(C)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D19 compound treatment 168720.0 99100.0 1.64 83840.0 12700.0 0.2 1.2995 0.7885 3063329 Maybridge4_001845 CC1=CC(=O)OC(C1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D20 compound treatment 158680.0 89000.0 1.47 75360.0 4210.0 0.07 1.0868 0.7386 1054135 Maybridge4_001846 CCc1c(O)nc2ccccn2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D21 compound treatment 83680.0 14000.0 0.23 57920.0 -13200.0 -0.21 0.0148 0.0472 1416442 Maybridge4_001847 CCN(CC)CCC1S(=O)(=O)CC(CS1(=O)=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D22 compound treatment 75280.0 5640.0 0.09 33760.0 -37400.0 -0.6 -0.3555 -0.5895 3179368 Maybridge4_001848 C(/N=C/c1cn(nc1c2ccccc2)c3ccccc3)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D23 mock treatment 95040.0 25400.0 0.42 46200.0 -25000.0 -0.4 0.0153 0.0265 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 D24 mock treatment 102800.0 33200.0 0.55 42120.0 -29000.0 -0.46 0.0599 0.0836 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E01 compound treatment 89720.0 20100.0 0.33 32720.0 -38400.0 -0.61 -0.1987 -0.2853 3063330 Maybridge4_001849 O=C(Nc1cccs1)N2CCN(CC2)C(=O)C3CCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E02 compound treatment 49360.0 -20300.0 -0.33 30000.0 -41200.0 -0.66 -0.7005 -0.9513 3179369 Maybridge4_001850 Clc1ccc(NC(=O)N2N=C3C(CCc4ccccc34)C2c5cccs5)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E03 compound treatment 71560.0 1920.0 0.03 38920.0 -32200.0 -0.51 -0.3408 -0.6622 3063331 Maybridge4_001851 CC(C)(C)c1cc(C(=O)NCc2ccc(C#N)cc2)n(Cc3ccccc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E04 compound treatment 50960.0 -18700.0 -0.31 48280.0 -22900.0 -0.36 -0.4758 -0.9965 3179370 Maybridge4_001852 C1Cc2ccccc2N1c3nnc(c4ccccc4)c(n3)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E05 compound treatment 92680.0 23000.0 0.38 59640.0 -11500.0 -0.18 0.1392 0.3297 3179371 Maybridge4_001853 Cn1nc(cc1C(F)(F)F)c2ccc(s2)S(=O)(=O)N3CCCN(CC3)C(=O)OC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E06 compound treatment 26840.0 -42800.0 -0.71 16560.0 -54600.0 -0.87 -1.1148 -0.9947 3063332 Maybridge4_001854 CCOC(=O)c1nnn2c1nc(Sc3nnc(c4ccncc4)n3C)c5ccccc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E07 compound treatment 142160.0 72500.0 1.2 83600.0 12500.0 0.2 0.9868 0.8132 3179372 Maybridge4_001855 Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCCN(CC2)C(=O)OC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E08 compound treatment 140640.0 71000.0 1.17 82920.0 11800.0 0.19 0.9614 0.81 1566406 Maybridge4_001856 CNc1nc(=S)[nH]c2sc3CCCCc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E09 compound treatment 175560.0 106000.0 1.75 93160.0 22000.0 0.35 1.4844 0.8324 3179373 Maybridge4_001857 OC[C@@H]1O[C@@H](C[C@H]1O)n2cnc3c(=O)[nH]cnc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E10 compound treatment 156800.0 87200.0 1.44 98480.0 27300.0 0.44 1.3254 0.8817 3063334 Maybridge4_001858 COc1ccc(Nc2ncc(C#N)c(N)n2)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E11 compound treatment 149840.0 80200.0 1.32 101240.0 30100.0 0.48 1.2753 0.9057 3179374 Maybridge4_001859 CCNc1nc(=S)[nH]c2n(ncc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E12 compound treatment 145600.0 76000.0 1.25 127680.0 56500.0 0.9 1.5238 0.9869 3063335 Maybridge4_001860 CCN(CC)c1ncc2c(=S)[nH]c(=S)[nH]c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E13 compound treatment 135880.0 66200.0 1.09 92400.0 21300.0 0.34 1.0127 0.8847 3179375 Maybridge4_001861 Cc1cc(C)c2c(n1)sc3c(Sc4nnc(o4)c5ccncc5)ncnc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E14 compound treatment 70800.0 1160.0 0.02 43920.0 -27200.0 -0.43 -0.2933 -0.6752 3179376 Maybridge4_001862 CCOC(=O)N1CCc2c(C1)sc3ncn(Cc4ccc(Cl)cc4)c(=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E15 compound treatment 85800.0 16200.0 0.27 57680.0 -13500.0 -0.21 0.0368 0.1076 3063336 Maybridge4_001863 Clc1ccccc1C2C3CCc4ccccc4C3=NN2C(=S)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E16 compound treatment 96680.0 27000.0 0.45 54880.0 -16300.0 -0.26 0.1323 0.2562 1616264 Maybridge4_001864 CC1=NN(C(=O)C1)c2ncnc3sc4CCCCc4c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E17 compound treatment 85640.0 16000.0 0.26 49360.0 -21800.0 -0.35 -0.0588 -0.1348 3179377 Maybridge4_001865 CCOC(=O)c1nnn2c1nc(N(Cc3ccccc3)Cc4ccccc4)c5ccccc52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E18 compound treatment 146640.0 77000.0 1.27 70960.0 -190.0 0.0 0.8966 0.7054 3063337 Maybridge4_001866 NNC(=O)/C(=C\c1ccccc1)/NC(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E19 compound treatment 117800.0 48200.0 0.8 75200.0 4050.0 0.06 0.6078 0.762 3179378 Maybridge4_001867 Cc1ccc(Cc2nn3c(nn(c4ccc(Cl)cc4)c3nc2=O)C(=O)c5cccs5)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E20 compound treatment 129880.0 60200.0 0.99 90400.0 19300.0 0.31 0.9201 0.8841 3063338 Maybridge4_001868 Fc1ccc(Cn2nc3CSc4ccccc4-n3c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E21 compound treatment 66920.0 -2720.0 -0.04 42160.0 -29000.0 -0.46 -0.3585 -0.7722 3063339 Maybridge4_001869 Cc1ccc2nc(C)c3CCN(c3c2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E22 compound treatment 68600.0 -1040.0 -0.02 21960.0 -49200.0 -0.78 -0.5665 -0.7224 3179379 Maybridge4_001870 Fc1ccc(/C=C\2/N=C(N(CC(=O)c3ccco3)C2=O)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E23 mock treatment 90880.0 21200.0 0.35 54800.0 -16400.0 -0.26 0.0637 0.1457 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 E24 mock treatment 79400.0 9760.0 0.16 35960.0 -35200.0 -0.56 -0.2827 -0.4844 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F01 compound treatment 92800.0 23200.0 0.38 31160.0 -40000.0 -0.64 -0.1803 -0.2426 3179475 Maybridge4_001871 Cc1cc(nc2oc3C(=O)N(CC(=O)Nc3c12)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F02 compound treatment 112560.0 42900.0 0.71 40640.0 -30500.0 -0.49 0.1571 0.1829 1429948 Maybridge4_001872 CC1(C)C(NC(=O)C2CCCCC2)[C@]3(C)CCC1C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F03 compound treatment 26720.0 -42900.0 -0.71 18320.0 -52800.0 -0.84 -1.0964 -0.9963 3179476 Maybridge4_001873 CCN(CC)c1ncc2c(NCc3ccccc3)nc(SCc4ccccc4)nc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F04 compound treatment 139840.0 70200.0 1.16 128160.0 57000.0 0.91 1.4619 0.9928 1050962 Maybridge4_001874 NC(=O)CCCCC1CCSS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F05 compound treatment 37040.0 -32600.0 -0.54 20400.0 -50800.0 -0.81 -0.9525 -0.9804 3179477 Maybridge4_001875 O=C(CN1CCc2ccccc12)Nc3scc4c3c(=O)oc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F06 compound treatment 106800.0 37200.0 0.61 65520.0 -5630.0 -0.09 0.3703 0.5973 3063341 Maybridge4_001876 CC1(C)C2CCC1(C)c3noc(c23)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F07 compound treatment 140320.0 70700.0 1.17 109800.0 38700.0 0.62 1.2606 0.9554 1040822 Maybridge4_001877 Cc1ccc(NC(=O)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F08 compound treatment 99640.0 30000.0 0.5 88920.0 17800.0 0.28 0.5505 0.9649 1502018 Maybridge4_001878 COc1ccc2oc(cc(=O)c2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F09 compound treatment 12840.0 -56800.0 -0.94 8840.0 -62300.0 -0.99 -1.3652 -0.9996 3063363 Maybridge4_001879 O=C1/C(=C/c2ccc(cc2)c3nnn[nH]3)/C(Oc4ccccc14)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F10 compound treatment 145160.0 75500.0 1.25 131200.0 60100.0 0.96 1.5583 0.9915 3063364 Maybridge4_001880 CC1(C)NC(=O)N(CC=C)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F11 compound treatment 26920.0 -42700.0 -0.71 23840.0 -47300.0 -0.75 -1.0318 -0.9994 3063365 Maybridge4_001881 Clc1ccccc1CNC(=S)NC2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F12 compound treatment 87640.0 18000.0 0.3 88800.0 17700.0 0.28 0.409 0.9996 3063366 Maybridge4_001882 Fc1ccc(cc1)N(Cc2ccc(Br)cc2)C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F13 compound treatment 10560.0 -59100.0 -0.98 9120.0 -62000.0 -0.99 -1.3887 -1.0 1687915 Maybridge4_001883 CC1(C)CC(=O)C=C(C1)Sc2nc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F14 compound treatment 144360.0 74700.0 1.23 130800.0 59700.0 0.95 1.5444 0.9917 3063367 Maybridge4_001884 C[n+]1ccc(CCc2cc[n+](C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F15 compound treatment 110880.0 41200.0 0.68 97760.0 26600.0 0.42 0.7813 0.9741 1612566 Maybridge4_001885 CCC(=O)N1N(C(=O)CC)c2cc(Cl)ccc2-n3c1nn(C(=O)CC)c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F16 compound treatment 21080.0 -48600.0 -0.8 11240.0 -59900.0 -0.95 -1.242 -0.9962 1406161 Maybridge4_001886 CC(=O)Oc1c(I)c(=O)n(C)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F17 compound treatment 140760.0 71100.0 1.17 67520.0 -3630.0 -0.06 0.7892 0.6714 3179478 Maybridge4_001887 CCSC(=O)NC1CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F18 compound treatment 130600.0 61000.0 1.01 59120.0 -12000.0 -0.19 0.576 0.5623 3179479 Maybridge4_001888 C1C(=CC(=NN=C1c2ccccc2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F19 compound treatment 178920.0 109000.0 1.8 166000.0 94900.0 1.51 2.3446 0.9961 1002179 Maybridge4_001889 Clc1ccc(cc1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F20 compound treatment 107280.0 37600.0 0.62 79400.0 8250.0 0.13 0.5323 0.8382 3063368 Maybridge4_001890 CCC(C)Sc1nnc(S)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F21 compound treatment 92960.0 23300.0 0.38 81080.0 9930.0 0.16 0.3841 0.9229 3179480 Maybridge4_001891 COC(=O)/C(=C/c1ccccc1)/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F22 compound treatment 108280.0 38600.0 0.64 66080.0 -5070.0 -0.08 0.3939 0.6126 1172572 Maybridge4_001892 O=c1[nH]cc(NCc2ccccc2)c(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F23 mock treatment 86320.0 16700.0 0.28 61920.0 -9230.0 -0.15 0.0907 0.2905 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 F24 mock treatment 79360.0 9720.0 0.16 32520.0 -38600.0 -0.62 -0.3219 -0.5059 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G01 compound treatment 70320.0 681.0 0.01 42160.0 -29000.0 -0.46 -0.3188 -0.6897 3179481 Maybridge4_001893 CCOC(=O)N1CCC(CC1)NC(=O)CCCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G02 compound treatment 60080.0 -9560.0 -0.16 21920.0 -49200.0 -0.78 -0.6664 -0.8326 3179482 Maybridge4_001894 O=C1CSC2=NC3=C(CCc4ccccc34)C(N12)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G03 compound treatment 89040.0 19400.0 0.32 60480.0 -10700.0 -0.17 0.1062 0.2929 3063369 Maybridge4_001895 CCOC(=O)c1ncn(Cc2ccccc2)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G04 compound treatment 144080.0 74400.0 1.23 107720.0 36600.0 0.58 1.2811 0.9419 3063370 Maybridge4_001896 S=c1[nH]nc(Cn2nnc3ccccc23)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G05 compound treatment 82760.0 13100.0 0.22 59400.0 -11800.0 -0.19 0.0207 0.0724 3179483 Maybridge4_001897 COc1cccc(Cc2nnc(o2)c3ccc(s3)c4cccs4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G06 compound treatment 50680.0 -19000.0 -0.31 32320.0 -38800.0 -0.62 -0.6589 -0.9501 3063371 Maybridge4_001898 Cn1nc2c3ccccc3n(Cc4ccccc4)c2nc1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G07 compound treatment 115440.0 45800.0 0.76 99080.0 27900.0 0.45 0.8494 0.9681 3179484 Maybridge4_001899 CCOC(=O)c1cnn(C(=O)Cc2cccc(OC)c2)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G08 compound treatment 102560.0 32900.0 0.54 89240.0 18100.0 0.29 0.5881 0.956 1696254 Maybridge4_001900 COc1cc(OC)c2nc(C)c3CCSc3c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G09 compound treatment 129400.0 59800.0 0.99 117600.0 46500.0 0.74 1.2211 0.99 3179485 Maybridge4_001901 CC(=O)Nc1ccccc1OCC2CC(=NO2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G10 compound treatment 74080.0 4440.0 0.07 69400.0 -1750.0 -0.03 0.0321 0.4095 3179486 Maybridge4_001902 C1Sc2nnc(c3ccccc3)n2N=C1c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G11 compound treatment 52680.0 -17000.0 -0.28 44760.0 -26400.0 -0.42 -0.4954 -0.9804 3063373 Maybridge4_001903 S=c1nc(Nc2ccccc2)c3cnn(c4ccccc4)c3[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G12 compound treatment 133920.0 64300.0 1.06 143360.0 72200.0 1.15 1.5641 0.9992 3179487 Maybridge4_001904 CN1CCN(CC1)c2ncc3c(=S)[nH]c(=S)[nH]c3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G13 compound treatment 10280.0 -59400.0 -0.98 9480.0 -61700.0 -0.98 -1.3879 -1.0 3063374 Maybridge4_001905 CCn1c(Sc2ncnc3c2sc4nc(C)cc(C)c43)nnc1c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G14 compound treatment 62840.0 -6800.0 -0.11 61240.0 -9910.0 -0.16 -0.191 -0.986 3179488 Maybridge4_001906 CCOC(=O)N1CCc2c(C(=O)OCC)c(NC(=S)N3CCc4ccccc34)sc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G15 compound treatment 73080.0 3440.0 0.06 76760.0 5610.0 0.09 0.1034 0.976 3179489 Maybridge4_001907 CCNC(=S)N1N=C2C(CCc3ccccc23)C1c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G16 compound treatment 43760.0 -25900.0 -0.43 51600.0 -19600.0 -0.31 -0.5224 -0.988 1303898 Maybridge4_001908 CC1=NN(C(=O)C1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G17 compound treatment 108000.0 38400.0 0.63 71480.0 330.0 0.01 0.4515 0.713 3063375 Maybridge4_001909 CCOC(=O)C1=NN(C2N1CCc3cc(OC)c(OC)cc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G18 compound treatment 71440.0 1800.0 0.03 63840.0 -7310.0 -0.12 -0.0614 -0.5103 3179490 Maybridge4_001910 COc1cc(/C=C\2/N=C(N(C)C2=O)c3ccccc3)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G19 compound treatment 71520.0 1880.0 0.03 62960.0 -8190.0 -0.13 -0.0703 -0.5243 3063377 Maybridge4_001911 Cc1c(C)c(=O)n(Cc2ccc(Br)cc2)c(=O)n1Cc3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G20 compound treatment 58760.0 -10900.0 -0.18 72120.0 970.0 0.02 -0.116 -0.6438 3179491 Maybridge4_001912 O=C(Cn1nc2CSc3ccccc3-n2c1=O)NC(=O)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G21 compound treatment 117120.0 47500.0 0.78 120240.0 49100.0 0.78 1.1075 1.0 3179492 Maybridge4_001913 CCOC(=O)c1sc2nc(C)cc(C)c2c1NC(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G22 compound treatment 45400.0 -24200.0 -0.4 61680.0 -9470.0 -0.15 -0.3897 -0.9112 1150256 Maybridge4_001914 N(c1ccccc1)c2ncnc3sc(cc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G23 mock treatment 86840.0 17200.0 0.28 59040.0 -12100.0 -0.19 0.0643 0.1873 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 G24 mock treatment 68080.0 -1560.0 -0.03 51880.0 -19300.0 -0.31 -0.2354 -0.7637 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H01 compound treatment 65320.0 -4320.0 -0.07 45480.0 -25700.0 -0.41 -0.3397 -0.818 3179493 Maybridge4_001915 COc1cc(cc(OC)c1OC)c2nnc(SCC(=O)c3ccco3)n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H02 compound treatment 5840.0 -63800.0 -1.05 4600.0 -66600.0 -1.06 -1.4947 -1.0 1202312 Maybridge4_001916 Clc1ccc(OC2CN(C2)C(=O)N3CC(C3)Oc4ccc(Cl)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H03 compound treatment 100480.0 30800.0 0.51 90760.0 19600.0 0.31 0.581 0.9726 3179494 Maybridge4_001917 O=C(CN1CCc2ccccc12)Nc3nnc(s3)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H04 compound treatment 110480.0 40800.0 0.67 89640.0 18500.0 0.29 0.6851 0.9311 1178262 Maybridge4_001918 COc1ccc(cc1)c2nc3cc4Nc5ccccc5Oc4cc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H05 compound treatment 36040.0 -33600.0 -0.55 33520.0 -37600.0 -0.6 -0.8163 -0.9992 3063402 Maybridge4_001919 O=C(Nc1scc2c1c(=O)oc3ccccc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H06 compound treatment 144640.0 75000.0 1.24 111560.0 40400.0 0.64 1.3309 0.9536 3179495 Maybridge4_001920 FC(F)(F)C(NC(=O)c1cccnc1)(N2CCCC2=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H07 compound treatment 137600.0 68000.0 1.12 135520.0 64400.0 1.03 1.5187 0.999 1117011 Maybridge4_001921 COc1cccc(NC(=O)N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H08 compound treatment 128120.0 58500.0 0.97 118840.0 47700.0 0.76 1.2201 0.993 3063403 Maybridge4_001922 NC(=O)c1cc(Cl)c(Cl)cc1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H09 compound treatment 125720.0 56100.0 0.93 116760.0 45600.0 0.73 1.1686 0.9928 3179496 Maybridge4_001923 O[C@H]1[C@@H](Oc2ccccc2C1=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H10 compound treatment 145600.0 76000.0 1.25 137800.0 66700.0 1.06 1.6378 0.9966 3063404 Maybridge4_001924 COc1ncnc(OC)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H11 compound treatment 20840.0 -48800.0 -0.81 21840.0 -49300.0 -0.79 -1.1253 -0.9999 1558852 Maybridge4_001925 CC1=C(C(C2=C(N1)c3ccccc3C2=O)c4ccccc4)C(=O)Nc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H12 compound treatment 153600.0 84000.0 1.39 159320.0 88200.0 1.41 1.9737 1.0 1698244 Maybridge4_001926 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H13 compound treatment 148160.0 78500.0 1.3 145360.0 74200.0 1.18 1.7529 0.999 1372400 Maybridge4_001927 O=c1c(c[nH]c2ccccc12)c3nnnn3c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H14 compound treatment 64640.0 -5000.0 -0.08 72320.0 1170.0 0.02 -0.0452 -0.5338 3179497 Maybridge4_001928 N1[C@H]([C@H](N=C1c2ccccc2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H15 compound treatment 129440.0 59800.0 0.99 135400.0 64300.0 1.02 1.4221 0.9998 3063405 Maybridge4_001929 CO[C@H]1O[C@H](COC(=O)c2ccccc2)[C@@H](O)[C@H](O)[C@H]1OC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H16 compound treatment 110880.0 41200.0 0.68 129080.0 57900.0 0.92 1.1343 0.9888 1081881 Maybridge4_001930 COC(=O)CSc1nc2ccccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H17 compound treatment 115240.0 45600.0 0.75 110280.0 39100.0 0.62 0.9733 0.9956 3063406 Maybridge4_001931 CC(C)N(C(C)C)C(=O)NCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H18 compound treatment 8920.0 -60700.0 -1.0 8120.0 -63000.0 -1.0 -1.4191 -1.0 3179498 Maybridge4_001932 Clc1ccc(cc1)c2nc(SCc3ccccc3)[nH]c(=S)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H19 compound treatment 125560.0 55900.0 0.92 123640.0 52500.0 0.84 1.2443 0.9988 3063407 Maybridge4_001933 OC(=O)c1cc(F)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H20 compound treatment 101200.0 31600.0 0.52 66880.0 -4270.0 -0.07 0.3203 0.6096 1198061 Maybridge4_001934 CC(Oc1ccc(Cl)cc1Cl)c2n[nH]c(=S)n2CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H21 compound treatment 82880.0 13200.0 0.22 64720.0 -6430.0 -0.1 0.0821 0.34 3179499 Maybridge4_001935 FC(F)(F)C(NC1CCCCC1)(NC(=O)c2ccccc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H22 compound treatment 35320.0 -34300.0 -0.57 31640.0 -39500.0 -0.63 -0.8459 -0.9986 1345621 Maybridge4_001936 O=c1[nH][nH]c(=O)n1CCCc2cc3cccc4ccc5cccc2c5c43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H23 mock treatment 108840.0 39200.0 0.65 94480.0 23300.0 0.37 0.7205 0.9654 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 H24 mock treatment 39520.0 -30100.0 -0.5 42840.0 -28300.0 -0.45 -0.6706 -0.9988 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I01 compound treatment 26440.0 -43200.0 -0.71 28200.0 -43000.0 -0.68 -0.9883 -0.9998 3179500 Maybridge4_001937 NC(=O)c1ccccc1NCC(=O)c2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I02 compound treatment 50600.0 -19000.0 -0.31 62200.0 -8950.0 -0.14 -0.3231 -0.9361 1786031 Maybridge4_001938 S=c1[nH]nc(Cc2ccccc2)n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I03 compound treatment 103840.0 34200.0 0.56 73280.0 2130.0 0.03 0.4232 0.7483 1416652 Maybridge4_001939 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I04 compound treatment 124760.0 55100.0 0.91 113320.0 42200.0 0.67 1.1187 0.9889 3179586 Maybridge4_001940 CNC(=O)NC(=O)CSc1nnc(Cc2ccccc2)n1c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I05 compound treatment 112440.0 42800.0 0.71 106120.0 35000.0 0.56 0.8937 0.9931 3063409 Maybridge4_001941 Cn1cc(cn1)S(=O)(=O)Nc2ccc(Oc3c(Cl)cccc3Cl)nc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I06 compound treatment 103000.0 33400.0 0.55 83920.0 12800.0 0.2 0.5333 0.9084 3179587 Maybridge4_001942 Clc1ccccc1CC(C(=O)N2CCc3ccccc23)C(=O)N4CCc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I07 compound treatment 100640.0 31000.0 0.51 108000.0 36900.0 0.59 0.7772 0.9976 3063410 Maybridge4_001943 CCOC(=O)c1cnn(C(=O)c2ccc(cc2)n3c(C)ccc3C)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I08 compound treatment 111080.0 41400.0 0.68 123160.0 52000.0 0.83 1.0699 0.9954 1500802 Maybridge4_001944 NC(=O)c1nnc2ccc(Cl)cc2c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I09 compound treatment 103280.0 33600.0 0.56 110520.0 39400.0 0.63 0.8364 0.9981 1103360 Maybridge4_001945 FC(F)(F)c1ccc(cc1)C(=O)CN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I10 compound treatment 125920.0 56300.0 0.93 150000.0 78900.0 1.26 1.5456 0.9889 3179588 Maybridge4_001946 O=C(CSc1nnc2NCCCn12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I11 compound treatment 111440.0 41800.0 0.69 122040.0 50900.0 0.81 1.0615 0.9968 1721477 Maybridge4_001947 Cc1nn(c2NC3=C(C(c12)c4cccnc4)C(=O)CC(C)(C)C3)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I12 compound treatment 154760.0 85100.0 1.41 155840.0 84700.0 1.35 1.948 0.9998 1444715 Maybridge4_001948 Cc1nc2cc(C)ccn2c1c3nnco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I13 compound treatment 146480.0 76800.0 1.27 155080.0 83900.0 1.34 1.8428 0.9996 3063411 Maybridge4_001949 Cc1cc(C)c(C#N)c(Sc2ncnc3c2sc4nc(C)cc(C)c43)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I14 compound treatment 119440.0 49800.0 0.82 124360.0 53200.0 0.85 1.181 0.9999 3179589 Maybridge4_001950 COc1ccc(cc1)n2c(n[nH]c2=S)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I15 compound treatment 101960.0 32300.0 0.53 139000.0 67900.0 1.08 1.142 0.947 3179590 Maybridge4_001951 CNC(=S)N1N=C2C(CCc3ccccc23)C1c4ccc(OC)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I16 compound treatment 59760.0 -9880.0 -0.16 74320.0 3170.0 0.05 -0.0796 -0.4662 3063412 Maybridge4_001952 CCOC(=O)N1CCc2c(C1)sc3[nH]c(=S)n(c4ccccc4)c(=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I17 compound treatment 32440.0 -37200.0 -0.61 26360.0 -44800.0 -0.71 -0.939 -0.9972 3179591 Maybridge4_001953 COc1cc2CCn3c(C(=O)c4cccs4)c(c(C#N)c3-c2cc1OC)c5ccc(C)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I18 compound treatment 69680.0 41.3 0.0 64920.0 -6230.0 -0.1 -0.0697 -0.7022 3063413 Maybridge4_001954 Fc1ccc(CN2C(=O)/C(=C\c3ccc(F)cc3)/N=C2c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I19 compound treatment 117720.0 48100.0 0.79 140680.0 69500.0 1.11 1.3448 0.9866 3179592 Maybridge4_001955 CCC(C)[C@H](NC(=O)c1ccco1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I20 compound treatment 56800.0 -12800.0 -0.21 54960.0 -16200.0 -0.26 -0.3323 -0.9952 3179593 Maybridge4_001956 COc1cccc(c1)C(=O)c2sc3nsc(SCc4ccccc4)c3c2N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I21 compound treatment 76840.0 7200.0 0.12 75480.0 4330.0 0.07 0.1329 0.9665 3063414 Maybridge4_001957 Cc1cc(C)c2c(N)c(sc2n1)c3nnc(SCC(=O)c4ccccc4)n3CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I22 compound treatment 128200.0 58600.0 0.97 121720.0 50600.0 0.81 1.2535 0.9959 3179594 Maybridge4_001958 C=CCn1nc2CSc3ccccc3-n2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I23 mock treatment 78880.0 9240.0 0.15 115120.0 44000.0 0.7 0.6034 0.8413 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 I24 mock treatment 35800.0 -33800.0 -0.56 49280.0 -21900.0 -0.35 -0.6415 -0.9742 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J01 compound treatment 16600.0 -53000.0 -0.88 30800.0 -40400.0 -0.64 -1.0738 -0.9885 3179595 Maybridge4_001959 CCOC(=O)CSc1nc(CN2c3ccccc3Sc4ccccc24)n[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J02 compound treatment 98280.0 28600.0 0.47 68200.0 -2950.0 -0.05 0.3011 0.6337 1402836 Maybridge4_001960 NS(=O)(=O)c1ccc(Cl)cc1Sc2ccccc2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J03 compound treatment 36880.0 -32800.0 -0.54 41840.0 -29300.0 -0.47 -0.7127 -0.9973 3179596 Maybridge4_001961 CCOC(=O)Cn1c(nc(c1c2ccccc2)c3ccccc3)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J04 compound treatment 89480.0 19800.0 0.33 126720.0 55600.0 0.89 0.8579 0.9085 1114912 Maybridge4_001962 NNC(=O)CNC(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J05 compound treatment 42840.0 -26800.0 -0.44 72840.0 1690.0 0.03 -0.2938 -0.6628 3179597 Maybridge4_001963 Fc1ccc(COc2nc(cc(c3ccco3)c2C#N)c4cccs4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J06 compound treatment 117480.0 47800.0 0.79 125600.0 54500.0 0.87 1.1721 0.9989 3063348 Maybridge4_001964 FC(F)(F)C(NCc1ccccn1)(NC(=O)c2cccnc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J07 compound treatment 40040.0 -29600.0 -0.49 35600.0 -35600.0 -0.57 -0.7461 -0.9973 3179598 Maybridge4_001965 COc1ccc(/N=C/c2cn(cc2\C=N\c3ccc(OC)cc3)c4ccc(OC)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J08 compound treatment 9040.0 -60600.0 -1.0 10280.0 -60900.0 -0.97 -1.3934 -0.9999 1550362 Maybridge4_001966 OC(=O)c1ccccc1NC(=O)OCC2c3ccccc3-c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J09 compound treatment 8800.0 -60800.0 -1.0 10440.0 -60700.0 -0.97 -1.3943 -0.9998 3179599 Maybridge4_001967 CC1(C)CC(=O)C=C(C1)Sc2nc3cc(Cl)ccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J10 compound treatment 124040.0 54400.0 0.9 146920.0 75800.0 1.21 1.4889 0.9894 1156147 Maybridge4_001968 COc1ccc2nc3n(C)c(=O)n(C)c(=O)c3cc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J11 compound treatment 11920.0 -57700.0 -0.95 14960.0 -56200.0 -0.9 -1.307 -0.9995 3179600 Maybridge4_001969 O=C1C2=C(NC(=S)NC2c3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J12 compound treatment 139360.0 69700.0 1.15 164720.0 93600.0 1.49 1.8684 0.9918 1727811 Maybridge4_001970 COc1cc(CCC(C)NC(=O)c2ccco2)ccc1OC(=O)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J13 compound treatment 150320.0 80700.0 1.33 170760.0 99600.0 1.59 2.0644 0.9962 3063350 Maybridge4_001971 COc1ccc(C#N)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J14 compound treatment 119520.0 49900.0 0.82 159600.0 88500.0 1.41 1.5791 0.9672 1014022 Maybridge4_001972 O=S(=O)(Cc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J15 compound treatment 114680.0 45000.0 0.74 145360.0 74200.0 1.18 1.3621 0.975 3179601 Maybridge4_001973 Nc1n/c(=N\c2ccccc2)/n(c3ccccc3)c(=N)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J16 compound treatment 91800.0 22200.0 0.37 80400.0 9250.0 0.15 0.3629 0.9202 3063351 Maybridge4_001974 FC(F)(F)c1ccccc1/N=C/2\CCCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J17 compound treatment 103360.0 33700.0 0.56 140440.0 69300.0 1.1 1.1745 0.9497 3179602 Maybridge4_001975 COCOc1ccc(cc1OC)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J18 compound treatment 53200.0 -16400.0 -0.27 96080.0 24900.0 0.4 0.0891 0.1851 1465673 Maybridge4_001976 CC(Nc1ccccc1)(C#N)c2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J19 compound treatment 45360.0 -24300.0 -0.4 64320.0 -6830.0 -0.11 -0.3604 -0.8677 3179603 Maybridge4_001977 c1ccc(cc1)c2nnc(o2)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J20 compound treatment 98800.0 29200.0 0.48 116760.0 45600.0 0.73 0.8544 0.98 1519121 Maybridge4_001978 CC(Oc1ccccc1c2ccccc2)c3n[nH]c(=S)n3c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J21 compound treatment 106160.0 36500.0 0.6 147800.0 76700.0 1.22 1.2902 0.947 3063353 Maybridge4_001979 COC(NC(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J22 compound treatment 92720.0 23100.0 0.38 113040.0 41900.0 0.67 0.7415 0.9646 1009264 Maybridge4_001980 CC(NC(=O)C)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J23 mock treatment 76360.0 6720.0 0.11 107640.0 36500.0 0.58 0.4897 0.8271 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 J24 mock treatment 63320.0 -6320.0 -0.1 68560.0 -2590.0 -0.04 -0.1029 -0.9177 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K01 compound treatment 41880.0 -27800.0 -0.46 76920.0 5770.0 0.09 -0.259 -0.5541 3179604 Maybridge4_001981 OC(=O)CSCC(=O)N1CCCN(CC1)c2ccc(cn2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K02 compound treatment 59920.0 -9720.0 -0.16 96240.0 25100.0 0.4 0.1693 0.393 3063380 Maybridge4_001982 CCOC(=O)c1nnn2c1nc(SCC(=O)N)c3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K03 compound treatment 55520.0 -14100.0 -0.23 87520.0 16400.0 0.26 0.0197 0.0563 3179605 Maybridge4_001983 COc1ccc(NC(=O)c2ccc(CN3CCS(=O)(=O)CC3)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K04 compound treatment 101920.0 32300.0 0.53 131440.0 60300.0 0.96 1.0563 0.9613 3063381 Maybridge4_001984 CNC(=O)NC(=O)CSc1nnc(c2ccncc2)n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K05 compound treatment 75280.0 5640.0 0.09 100320.0 29200.0 0.46 0.3946 0.8322 3179606 Maybridge4_001985 S=C(NCC1CC(=NO1)c2ccccc2)NCc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K06 compound treatment 112960.0 43300.0 0.72 121480.0 50300.0 0.8 1.0729 0.9984 3179607 Maybridge4_001986 CCOc1nc-2c(Cc3ccccc32)c(c4ccco4)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K07 compound treatment 64200.0 -5440.0 -0.09 86640.0 15500.0 0.25 0.1111 0.4229 3063383 Maybridge4_001987 Sc1nnc(Cc2ccsc2)n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K08 compound treatment 85720.0 16100.0 0.27 142640.0 71500.0 1.14 0.9934 0.8491 3179608 Maybridge4_001988 O=c1[nH]c-2c(CCc3ccccc32)c(c1C#N)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K09 compound treatment 20680.0 -49000.0 -0.81 24440.0 -46700.0 -0.74 -1.0979 -0.9992 3063384 Maybridge4_001989 C=CCSc1c2CCCc2c(C#N)c3nc4ccccc4n13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K10 compound treatment 100880.0 31200.0 0.52 142040.0 70900.0 1.13 1.1636 0.9369 3179609 Maybridge4_001990 O=C(N1CCCn2c(SCc3ccccc3)nnc12)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K11 compound treatment 103800.0 34200.0 0.56 122840.0 51700.0 0.82 0.9813 0.9829 3063386 Maybridge4_001991 CCNC(=S)Nc1sc2CC(C)CCc2c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K12 compound treatment 133520.0 63900.0 1.05 163120.0 92000.0 1.47 1.7822 0.9869 3179610 Maybridge4_001992 Cc1sc2nc3SCC(=Nn3c(=O)c2c1C)c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K13 compound treatment 141880.0 72200.0 1.19 160400.0 89300.0 1.42 1.8491 0.9962 3063387 Maybridge4_001993 CCOC(=O)c1oc2nc(cc(c3ccco3)c2c1N)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K14 compound treatment 86000.0 16400.0 0.27 147560.0 76400.0 1.22 1.0521 0.8434 3179611 Maybridge4_001994 C1Sc2ccccc2-n3c(nnc13)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K15 compound treatment 92800.0 23200.0 0.38 149480.0 78300.0 1.25 1.1531 0.8832 3179694 Maybridge4_001995 CCOC(=O)c1nnn2c1n(C)c(=O)c3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K16 compound treatment 73680.0 4040.0 0.07 132200.0 61100.0 0.97 0.7352 0.7538 3063389 Maybridge4_001996 O=c1c(nnc2sc3ccccc3n12)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K17 compound treatment 76880.0 7240.0 0.12 119360.0 48200.0 0.77 0.6279 0.8074 3179695 Maybridge4_001997 CCOC(=O)C1=NN(C2C1c3cccc4cccc2c34)c5ccc(C)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K18 compound treatment 50600.0 -19000.0 -0.31 63920.0 -7230.0 -0.12 -0.3037 -0.9073 3063390 Maybridge4_001998 Clc1ccccc1/C=C\2/N=C(N(CC=C)C2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K19 compound treatment 44400.0 -25200.0 -0.42 76560.0 5410.0 0.09 -0.2336 -0.5491 3179696 Maybridge4_001999 O=C(NCC1COc2ccccc2O1)Nc3csc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K20 compound treatment 43760.0 -25900.0 -0.43 69560.0 -1590.0 -0.03 -0.32 -0.7477 3179697 Maybridge4_002000 CNC(=O)NC(=O)CSc1ncnc2sc(cc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K21 compound treatment 31080.0 -38600.0 -0.64 39800.0 -31400.0 -0.5 -0.8034 -0.9928 3063391 Maybridge4_002001 Cc1cc(C)c2c(N)c(sc2n1)c3nnc(SCc4ccc(Cl)cc4)n3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K22 compound treatment 43800.0 -25800.0 -0.43 78040.0 6890.0 0.11 -0.2239 -0.5085 3179698 Maybridge4_002002 S=c1[nH]nc(CSc2nc(cn2c3ccccc3)c4ccccc4)n1c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K23 mock treatment 73840.0 4200.0 0.07 79920.0 8770.0 0.14 0.1479 0.9477 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 K24 mock treatment 38720.0 -30900.0 -0.51 103200.0 32100.0 0.51 3.0E-4 4.0E-4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L01 compound treatment 24480.0 -45200.0 -0.75 70400.0 -750.0 -0.01 -0.5356 -0.7184 3063422 Maybridge4_002003 CCOC(=O)CSc1nc(SCC(=O)OCC)c2c3CCCc3sc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L02 compound treatment 43720.0 -25900.0 -0.43 61120.0 -10000.0 -0.16 -0.4156 -0.9099 1536081 Maybridge4_002004 OC(=O)c1ccccc1Sc2ccccc2S(=O)(=O)NC3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L03 compound treatment 11960.0 -57700.0 -0.95 19120.0 -52000.0 -0.83 -1.2596 -0.9976 3179699 Maybridge4_002005 C=CCn1c(nc(c1c2ccccc2)c3ccccc3)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L04 compound treatment 24280.0 -45400.0 -0.75 53880.0 -17300.0 -0.28 -0.7241 -0.9077 1430538 Maybridge4_002006 COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L05 compound treatment 38840.0 -30800.0 -0.51 50760.0 -20400.0 -0.32 -0.5893 -0.9766 3179700 Maybridge4_002007 N=c1n(Nc2ccccc2)cnc3sc4CCCc4c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L06 compound treatment 79160.0 9520.0 0.16 123600.0 52500.0 0.84 0.7023 0.8256 3063426 Maybridge4_002008 Cc1ccc(cc1)C(=O)NC(NCc2ccco2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L07 compound treatment 105480.0 35800.0 0.59 161040.0 89900.0 1.43 1.4314 0.9235 3179701 Maybridge4_002009 Brc1ccc(s1)c2ccc(Br)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L08 compound treatment 100840.0 31200.0 0.52 183520.0 112000.0 1.79 1.6306 0.875 1371799 Maybridge4_002010 CCOC(=O)C(C)Oc1ccc2c(cc(=O)oc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L09 compound treatment 67160.0 -2480.0 -0.04 138720.0 67600.0 1.08 0.7326 0.6798 1134767 Maybridge4_002011 C1C(=Cc2ccccc12)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L10 compound treatment 134720.0 65100.0 1.07 160520.0 89400.0 1.42 1.7669 0.9903 1364288 Maybridge4_002012 O=C(NC1CCN(CC1)C(=O)C2CCC2)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L11 compound treatment 85560.0 15900.0 0.26 139200.0 68100.0 1.08 0.9528 0.8537 1570440 Maybridge4_002013 Oc1cc(Cc2ccccc2)cnc1CN3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L12 compound treatment 9880.0 -59800.0 -0.99 14000.0 -57200.0 -0.91 -1.3416 -0.9992 1227426 Maybridge4_002014 CC(C)C1CCC(C)CC1N(Cc2ccccc2)C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L13 compound treatment 101520.0 31900.0 0.53 133960.0 62800.0 1.0 1.08 0.9549 1583701 Maybridge4_002015 N[C@@H](CO)CSCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L14 compound treatment 77160.0 7520.0 0.12 120800.0 49700.0 0.79 0.6474 0.8082 1368346 Maybridge4_002016 COc1cc(CCc2cc(OC)c(C)cc2OC)c(OC)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L15 compound treatment 40800.0 -28800.0 -0.48 125640.0 54500.0 0.87 0.2775 0.2802 3063428 Maybridge4_002017 FC(F)(F)C(NC(=O)c1ccccc1)(Nc2ccccc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L16 compound treatment 20600.0 -49000.0 -0.81 80040.0 8890.0 0.14 -0.4722 -0.5746 1023708 Maybridge4_002018 COc1ccc(cc1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L17 compound treatment 55720.0 -13900.0 -0.23 84960.0 13800.0 0.22 -0.0068 -0.0214 1344186 Maybridge4_002019 CC(=O)N1C(C(=O)NC1=S)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L18 compound treatment 60080.0 -9560.0 -0.16 116840.0 45700.0 0.73 0.4034 0.5413 3179703 Maybridge4_002020 CC(C)C(C)(Nc1ccccc1)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L19 compound treatment 77560.0 7920.0 0.13 144560.0 73400.0 1.17 0.9198 0.7813 1047316 Maybridge4_002021 OC(=O)c1ccc(s1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L20 compound treatment 76040.0 6400.0 0.11 100760.0 29600.0 0.47 0.4084 0.8445 3179704 Maybridge4_002022 Brc1ccccc1C(=O)c2ccc-3c(c2)C(=O)c4ccccc43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L21 compound treatment 70600.0 961.0 0.02 117080.0 45900.0 0.73 0.5289 0.7223 3063451 Maybridge4_002023 FC(F)(F)C(NC(=O)c1ccccc1)(OCc2ccccc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L22 compound treatment 58080.0 -11600.0 -0.19 98320.0 27200.0 0.43 0.1713 0.362 3179705 Maybridge4_002024 CCOC(=O)CSc1nncc(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L23 mock treatment 61080.0 -8560.0 -0.14 97480.0 26300.0 0.42 0.1968 0.4445 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 L24 mock treatment 31720.0 -37900.0 -0.63 99520.0 28400.0 0.45 -0.1229 -0.1591 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M01 compound treatment 16840.0 -52800.0 -0.87 31520.0 -39600.0 -0.63 -1.0629 -0.9875 3063453 Maybridge4_002025 Cc1ccc(CNC(=O)Nc2ccccc2)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M02 compound treatment 15280.0 -54400.0 -0.9 33880.0 -37300.0 -0.59 -1.0545 -0.9799 3179706 Maybridge4_002026 CCOC(=O)c1nnn2c1nc(SCc3ccc(F)cc3)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M03 compound treatment 14000.0 -55600.0 -0.92 24040.0 -47100.0 -0.75 -1.1804 -0.995 3179707 Maybridge4_002027 O=C(Nc1ccc(OCc2ccccc2)cc1)OCC3CN(Cc4ccccc4)CCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M04 compound treatment 59720.0 -9920.0 -0.16 107960.0 36800.0 0.59 0.2991 0.491 3063456 Maybridge4_002028 O=C(CC(C(=O)N1CCc2ccccc12)C(=O)N3CCc4ccccc34)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M05 compound treatment 28840.0 -40800.0 -0.67 69920.0 -1230.0 -0.02 -0.4901 -0.7274 3179708 Maybridge4_002029 O=C(OCC1CC(=NO1)c2ccccc2)c3cccc(n3)C(=O)OCC4CC(=NO4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M06 compound treatment 79560.0 9920.0 0.16 130840.0 59700.0 0.95 0.7885 0.8168 3063457 Maybridge4_002030 CC1=Nn2c(Cn3nnc4ccccc34)nnc2SC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M07 compound treatment 12520.0 -57100.0 -0.94 95560.0 24400.0 0.39 -0.3916 -0.3839 3179709 Maybridge4_002031 C/C(=N\O)/C(C)(C)Nc1ccc(cc1)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M08 compound treatment 6240.0 -63400.0 -1.05 12720.0 -58400.0 -0.93 -1.3985 -0.9983 3063458 Maybridge4_002032 O=C(Oc1cc(=O)oc2c3cccc4CCn(c(=O)c12)c43)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M09 compound treatment 60480.0 -9160.0 -0.15 151480.0 80300.0 1.28 0.7984 0.6193 2096080 Maybridge4_002033 CCOC(=O)c1sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c2c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M10 compound treatment 56800.0 -12800.0 -0.21 76280.0 5130.0 0.08 -0.092 -0.4052 3179710 Maybridge4_002034 CCOC(=O)N1CCc2c(C#N)c(NC(=O)CN3CCc4ccccc34)sc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M11 compound treatment 15160.0 -54500.0 -0.9 35800.0 -35400.0 -0.56 -1.0343 -0.9746 3063459 Maybridge4_002035 O=C(COc1nc(cc(c2cccs2)c1C#N)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M12 compound treatment 137160.0 67500.0 1.11 167800.0 96700.0 1.54 1.8774 0.9874 3063460 Maybridge4_002036 O=c1n(CN2CCOCC2)nc3sc4ccccc4n3c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M13 compound treatment 20800.0 -48800.0 -0.81 41640.0 -29500.0 -0.47 -0.9026 -0.9671 3179711 Maybridge4_002037 Nc1c(oc2nc(cc(c3cccs3)c12)c4ccco4)C(=O)c5ccc(Cl)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M14 compound treatment 6400.0 -63200.0 -1.04 12240.0 -58900.0 -0.94 -1.4021 -0.9986 3063486 Maybridge4_002038 Cc1nc2n(ncc2c(=O)n1NC(=O)Nc3ccc(Cl)c(Cl)c3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M15 compound treatment 67240.0 -2400.0 -0.04 141280.0 70100.0 1.12 0.7624 0.6816 3179712 Maybridge4_002039 CCOC(=O)c1nnn2c1n(CC=C)c(=O)c3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M16 compound treatment 35840.0 -33800.0 -0.56 121200.0 50100.0 0.8 0.1696 0.1742 3063487 Maybridge4_002040 COC(=O)C1=C(C)N=C2SC(=C(N)N2C1c3cccs3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M17 compound treatment 11400.0 -58200.0 -0.96 39000.0 -32200.0 -0.51 -1.0421 -0.9566 3179713 Maybridge4_002041 O=C/1NN=C(\C1=C\2/OC(=CS2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M18 compound treatment 55720.0 -13900.0 -0.23 146880.0 75700.0 1.21 0.691 0.5624 3179714 Maybridge4_002042 Clc1ccc(CN2C(=O)/C(=C\c3cccs3)/N=C2c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M19 compound treatment 62240.0 -7400.0 -0.12 138240.0 67100.0 1.07 0.6698 0.6223 3063489 Maybridge4_002043 COc1ccc(cc1)n2ncc(NC(=O)N3CCOCC3)c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M20 compound treatment 77640.0 8000.0 0.13 119840.0 48700.0 0.78 0.6421 0.8157 3179715 Maybridge4_002044 O=c1c(nc(nn1CN2CCOCC2)c3ccccc3)C(CN4CCOCC4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M21 compound treatment 39880.0 -29800.0 -0.49 113200.0 42100.0 0.67 0.1266 0.1523 3063490 Maybridge4_002045 Clc1ccccc1C2C3CCc4ccccc4C3=NN2C(=O)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M22 compound treatment 45280.0 -24400.0 -0.4 154160.0 83000.0 1.32 0.6512 0.4709 3179716 Maybridge4_002046 CCOC(=O)c1cnc(nc1N)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M23 mock treatment 51800.0 -17800.0 -0.29 102200.0 31100.0 0.49 0.1417 0.2461 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 M24 mock treatment 26240.0 -43400.0 -0.72 85040.0 13900.0 0.22 -0.35 -0.4668 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N01 compound treatment 42880.0 -26800.0 -0.44 56560.0 -14600.0 -0.23 -0.4768 -0.9551 3063492 Maybridge4_002047 O=C1CSc2nnc(c3ccccc3)n12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N02 compound treatment 20480.0 -49200.0 -0.81 51520.0 -19600.0 -0.31 -0.795 -0.9141 1229835 Maybridge4_002048 OC(=O)c1ccccc1Sc2ccccc2S(=O)(=O)NC3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N03 compound treatment 9280.0 -60400.0 -1.0 42560.0 -28600.0 -0.46 -1.0267 -0.9371 1256899 Maybridge4_002049 c1csc(c1)c2nc(c([nH]2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N04 compound treatment 15680.0 -54000.0 -0.89 52120.0 -19000.0 -0.3 -0.8443 -0.8973 3178130 Maybridge4_002050 CCCc1cc(O)nc(SC/C=C/c2ccccc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N05 compound treatment 11200.0 -58400.0 -0.96 35440.0 -35700.0 -0.57 -1.0846 -0.9683 3178131 Maybridge4_002051 CCNc1nc(SCC(=O)NC(=O)NCc2ccccc2)nc3sc4CN(C)CCc4c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N06 compound treatment 3120.0 -66500.0 -1.1 9240.0 -61900.0 -0.99 -1.4742 -0.9986 3063494 Maybridge4_002052 CC1CN=C(S1)N(C2CCCCC2)C(=O)Nc3cccc(Cl)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N07 compound treatment 14280.0 -55400.0 -0.91 63120.0 -8030.0 -0.13 -0.7367 -0.7983 3178132 Maybridge4_002053 Cc1ccc(OC(=O)OCSc2nnn[nH]2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N08 compound treatment 44760.0 -24900.0 -0.41 165680.0 94500.0 1.51 0.775 0.4963 1423044 Maybridge4_002054 CC(Oc1ccc2c(cc(=O)oc2c1)c3ccccc3)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N09 compound treatment 40920.0 -28700.0 -0.47 117640.0 46500.0 0.74 0.1887 0.2146 1177114 Maybridge4_002055 Brc1ccc(cc1)N2C(=O)C3=C(C2=O)C(=NCCN3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N10 compound treatment 47200.0 -22400.0 -0.37 153560.0 82400.0 1.31 0.6669 0.4886 1659522 Maybridge4_002056 Clc1cccc(Cl)c1C(=O)N2CCC(CC2)NC(=O)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N11 compound treatment 62840.0 -6800.0 -0.11 156160.0 85000.0 1.35 0.8787 0.6463 1381385 Maybridge4_002057 CN1C(=O)N(c2ccc(Cl)cc2)C(C)(O)CC1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N12 compound treatment 108600.0 39000.0 0.64 138760.0 67600.0 1.08 1.2168 0.9696 1409714 Maybridge4_002058 COc1cccc(NC(=O)c2ccc(OC)c(OC)c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N13 compound treatment 87680.0 18000.0 0.3 122120.0 51000.0 0.81 0.785 0.9073 1704266 Maybridge4_002059 CC(C)(C)C(=O)Nc1ccccc1Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N14 compound treatment 84400.0 14800.0 0.24 132760.0 61600.0 0.98 0.8667 0.8566 3178133 Maybridge4_002060 NNC(=O)c1cc(S)ncn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N15 compound treatment 53120.0 -16500.0 -0.27 148000.0 76900.0 1.22 0.6733 0.5366 3063524 Maybridge4_002061 CC(=O)NC(Nc1ccccc1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N16 compound treatment 48520.0 -21100.0 -0.35 160600.0 89500.0 1.43 0.7616 0.5189 3178134 Maybridge4_002062 C/C(=N\c1ccccc1C(F)(F)F)/c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N17 compound treatment 38000.0 -31600.0 -0.52 151280.0 80100.0 1.28 0.5338 0.3869 1020871 Maybridge4_002063 O=C1NC(C(=O)N1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N18 compound treatment 21600.0 -48000.0 -0.79 101280.0 30100.0 0.48 -0.2212 -0.2386 1667495 Maybridge4_002064 Clc1ccc2[nH]c(=O)c3nc(oc3c2c1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N19 compound treatment 42960.0 -26700.0 -0.44 123280.0 52100.0 0.83 0.2761 0.2936 1670169 Maybridge4_002065 CC(C)c1ccc(cc1)S(=O)(=O)CC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N20 compound treatment 38400.0 -31200.0 -0.52 126360.0 55200.0 0.88 0.2576 0.2526 1596128 Maybridge4_002066 CCOC(=O)C1CCN(C1=O)S(=O)(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N21 compound treatment 31960.0 -37700.0 -0.62 120200.0 49100.0 0.78 0.113 0.1131 1008385 Maybridge4_002067 O=C(c1ccccc1)c2ccccc2C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N22 compound treatment 37600.0 -32000.0 -0.53 126440.0 55300.0 0.88 0.2492 0.2424 1546853 Maybridge4_002068 Cn1c(=O)n(C)c2ncn(CC(O)CN(CC=C)CC=C)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N23 mock treatment 40520.0 -29100.0 -0.48 110120.0 39000.0 0.62 0.0993 0.1265 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 N24 mock treatment 36240.0 -33400.0 -0.55 82040.0 10900.0 0.17 -0.2671 -0.4621 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O01 compound treatment 8120.0 -61500.0 -1.02 14800.0 -56400.0 -0.9 -1.3531 -0.9981 3063527 Maybridge4_002069 O=C(Nc1sccc1c2nc3ccccc3s2)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O02 compound treatment 50680.0 -19000.0 -0.31 107800.0 36700.0 0.58 0.1918 0.2894 3178135 Maybridge4_002070 CCOC(=O)CSc1nnc(Cn2nnc3ccccc23)n1c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O03 compound treatment 37000.0 -32600.0 -0.54 107480.0 36300.0 0.58 0.0285 0.036 3063528 Maybridge4_002071 Cc1ccc(cc1)S(=O)(=O)NC(=O)OCC2CN(Cc3ccccc3)CCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O04 compound treatment 42280.0 -27400.0 -0.45 101760.0 30600.0 0.49 0.0256 0.0386 3178136 Maybridge4_002072 Cn1nc2c3ccccc3n(CC=C)c2nc1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O05 compound treatment 10200.0 -59400.0 -0.98 32320.0 -38800.0 -0.62 -1.1314 -0.9753 3178137 Maybridge4_002073 Clc1ccc(cc1)n2ncc(n2)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O06 compound treatment 23960.0 -45700.0 -0.75 89640.0 18500.0 0.29 -0.3248 -0.4012 3178138 Maybridge4_002074 Brc1ccc(cc1)C2=Nn3c(Cn4nnc5ccccc45)nnc3SC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O07 compound treatment 41960.0 -27700.0 -0.46 118440.0 47300.0 0.75 0.2099 0.2381 1760428 Maybridge4_002075 O=C(Nc1ccc2OCCOc2c1)c3ccc4nccnc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O08 compound treatment 27000.0 -42600.0 -0.7 142880.0 71700.0 1.14 0.3107 0.2314 3178139 Maybridge4_002076 CNC(=O)NC(=O)CSc1nnc(o1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O09 compound treatment 21360.0 -48300.0 -0.8 143680.0 72500.0 1.16 0.2539 0.1808 3178140 Maybridge4_002077 CCOC(=O)COc1c(C#N)sc2n(c3ccccc3)c(=S)n(c4ccccc4)c(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O10 compound treatment 37120.0 -32500.0 -0.54 142760.0 71600.0 1.14 0.4275 0.3389 3063548 Maybridge4_002078 S=c1[nH]c(=S)c2cnc(nc2[nH]1)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O11 compound treatment 64040.0 -5600.0 -0.09 117920.0 46800.0 0.75 0.4618 0.6147 1200067 Maybridge4_002079 Cc1cc(C)c2c(N)c(sc2n1)C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O12 compound treatment 52280.0 -17400.0 -0.29 107400.0 36300.0 0.58 0.2059 0.3193 2102976 Maybridge4_002080 COc1ccc(cc1)C2=Nn3c(SC2)nc4sc5CCCCc5c4c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O13 compound treatment 4800.0 -64800.0 -1.07 9400.0 -61800.0 -0.98 -1.4528 -0.9991 3063550 Maybridge4_002081 Cc1cc(C)c(C#N)c(Sc2ncnc3n(Cc4ccccc4)nnc23)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O14 compound treatment 8440.0 -61200.0 -1.01 61640.0 -9510.0 -0.15 -0.8215 -0.8042 3178141 Maybridge4_002082 O=c1n(/N=C/c2cccs2)cnc3sc(cc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O15 compound treatment 7880.0 -61800.0 -1.02 50560.0 -20600.0 -0.33 -0.9529 -0.8898 3178142 Maybridge4_002083 CCOC(=O)c1nnn2c1n(Cc3ccc(Cl)cc3)c(=O)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O16 compound treatment 7920.0 -61700.0 -1.02 47120.0 -24000.0 -0.38 -0.9912 -0.9107 3063551 Maybridge4_002084 COc1cc(/C=N/n2c(C)nc3n(cnc3c2=O)c4ccccc4)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O17 compound treatment 28160.0 -41500.0 -0.68 120520.0 49400.0 0.79 0.0723 0.0693 3178143 Maybridge4_002085 O=c1nc2n(nc(c3ccccc3)n2c(c1C#N)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O18 compound treatment 30480.0 -39200.0 -0.65 92440.0 21300.0 0.34 -0.2171 -0.2974 3063552 Maybridge4_002086 C1Cc2ccccc2N1c3ncnc4sc(cc34)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O19 compound treatment 30560.0 -39100.0 -0.65 121720.0 50600.0 0.81 0.1138 0.1102 3178144 Maybridge4_002087 COc1ccc(cc1)n2ncc(NC(=O)Nc3ccc4OCCCOc4c3)c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O20 compound treatment 31480.0 -38200.0 -0.63 123400.0 52300.0 0.83 0.1435 0.1374 3063553 Maybridge4_002088 Nc1ncnc2nc(ncc12)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O21 compound treatment 35400.0 -34200.0 -0.57 73240.0 2090.0 0.03 -0.3761 -0.6643 3178145 Maybridge4_002089 CC(=O)N1N=C2C(CCc3ccccc23)C1c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O22 compound treatment 43800.0 -25800.0 -0.43 128560.0 57400.0 0.92 0.3454 0.3422 3063554 Maybridge4_002090 Cc1cc(=O)n2ncnc2n1CC(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O23 mock treatment 57760.0 -11900.0 -0.2 116080.0 44900.0 0.72 0.3677 0.4953 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 O24 mock treatment 43160.0 -26500.0 -0.44 101920.0 30800.0 0.49 0.0377 0.0574 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P01 compound treatment 36160.0 -33500.0 -0.55 42800.0 -28400.0 -0.45 -0.7103 -0.995 1504248 Maybridge4_002091 C1Cc2ccccc2N1c3ncnc4n(ncc34)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P02 compound treatment 7480.0 -62200.0 -1.03 12960.0 -58200.0 -0.93 -1.3814 -0.9987 1485949 Maybridge4_002092 CC(CN1CCN(Cc2ccccc2)CC1)N(C(=O)c3ccc(cc3)C(C)(C)C)c4ccccn4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P03 compound treatment 15560.0 -54100.0 -0.89 38440.0 -32700.0 -0.52 -0.9999 -0.9672 3063615 Maybridge4_002093 O=C/1NNC(=N\C1=C/c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P04 compound treatment 44080.0 -25600.0 -0.42 116960.0 45800.0 0.73 0.218 0.2585 3178146 Maybridge4_002094 Cn1cnnc1Sc2cc(C#N)c(C#N)cc2Sc3nncn3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P05 compound treatment 1880.0 -67800.0 -1.12 6520.0 -64600.0 -1.03 -1.5193 -0.9992 3063618 Maybridge4_002095 CCNc1nc(SCc2ccc(Cl)cc2)nc3sc4CN(C)CCc4c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P06 compound treatment 21400.0 -48200.0 -0.8 117560.0 46400.0 0.74 -0.04 -0.0368 3178147 Maybridge4_002096 Cn1cnc(c1C#N)n2oo2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P07 compound treatment 39360.0 -30300.0 -0.5 143640.0 72500.0 1.16 0.4636 0.3682 1405262 Maybridge4_002097 O=C(NCc1ccccc1)NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P08 compound treatment 8080.0 -61600.0 -1.02 45480.0 -25700.0 -0.41 -1.0078 -0.92 1585718 Maybridge4_002098 CCOC(=O)C(C)Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P09 compound treatment 30120.0 -39500.0 -0.65 143160.0 72000.0 1.15 0.3503 0.2653 3178148 Maybridge4_002099 COC(=O)/C(=C/C(=O)c1c(F)c(F)c(OC)c(F)c1F)/O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P10 compound treatment 28960.0 -40700.0 -0.67 162840.0 91700.0 1.46 0.5585 0.3473 1497616 Maybridge4_002100 O=C(Cc1ccccc1)NC2CCN(CC2)C(=O)C3CCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P11 compound treatment 41400.0 -28200.0 -0.47 138440.0 67300.0 1.07 0.4288 0.3666 3178149 Maybridge4_002101 O=c1ccc2CCCCc2n1CCC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P12 compound treatment 35080.0 -34600.0 -0.57 105360.0 34200.0 0.55 -0.0178 -0.0226 1054556 Maybridge4_002102 Cc1ccc(NS(=O)(=O)c2ccccc2)c(NS(=O)(=O)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P13 compound treatment 58560.0 -11100.0 -0.18 138640.0 67500.0 1.08 0.6313 0.5786 1043550 Maybridge4_002103 OC1CCN(Cc2ccccc2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P14 compound treatment 41720.0 -27900.0 -0.46 128200.0 57100.0 0.91 0.3171 0.311 1240290 Maybridge4_002104 CC(C)(C)OC(=O)N1CCN(Cc2ccccc2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P15 compound treatment 46320.0 -23300.0 -0.38 117840.0 46700.0 0.74 0.254 0.3032 3063648 Maybridge4_002105 CC(=O)NC(NCc1ccccc1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P16 compound treatment 39320.0 -30300.0 -0.5 150440.0 79300.0 1.26 0.5397 0.3971 3178234 Maybridge4_002106 CC(C)[C@H]1COC(=N1)c2cccc(n2)C3=N[C@H](CO3)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P17 compound treatment 37440.0 -32200.0 -0.53 120720.0 49600.0 0.79 0.1828 0.192 3063650 Maybridge4_002107 CC(O)/C=C/c1cccc[n+]1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P18 compound treatment 56440.0 -13200.0 -0.22 135280.0 64100.0 1.02 0.5687 0.5442 3178235 Maybridge4_002108 CCOC(=O)C1=C(C)N(C(=O)Oc2ccccc2)C(=NC1c3ccccc3)SC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P19 compound treatment 30560.0 -39100.0 -0.65 99920.0 28800.0 0.46 -0.1319 -0.1667 3063651 Maybridge4_002109 CN1C(=O)/C(=C\Nc2ccc(Cl)cc2)/C(=O)c3c1n(C)c(=O)n(C)c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P20 compound treatment 25360.0 -44300.0 -0.73 87480.0 16300.0 0.26 -0.3328 -0.4289 1466385 Maybridge4_002110 COC(=O)C1=C(C)NC(=C(C1C)C(=O)OC)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P21 compound treatment 15840.0 -53800.0 -0.89 32040.0 -39100.0 -0.62 -1.0687 -0.985 1646281 Maybridge4_002111 COc1cccc(c1)c2ncc(o2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P22 compound treatment 26720.0 -42900.0 -0.71 44000.0 -27200.0 -0.43 -0.807 -0.972 1592521 Maybridge4_002112 O=C(Nc1ccccc1)N(Cc2ccccc2)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P23 mock treatment 36160.0 -33500.0 -0.55 71720.0 570.0 0.01 -0.3844 -0.6954 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2054 P24 mock treatment 63120.0 -6520.0 -0.11 44160.0 -27000.0 -0.43 -0.3803 -0.8576 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A01 compound treatment 27720.0 -42500.0 -0.7 58480.0 -54600.0 -0.87 -1.1116 -0.9944 3178236 Maybridge4_002113 CCOC(=O)c1c(C)n[nH]c1/N=C/c2ccc(OC)c(OC)c2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A02 compound treatment 69480.0 -775.0 -0.01 79520.0 -33500.0 -0.53 -0.3871 -0.7238 3178237 Maybridge4_002114 CS/C(=C(/C#N)\S(=O)(=O)c1ccc(Cl)cc1)/NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A03 compound treatment 99240.0 29000.0 0.48 180800.0 67700.0 1.08 1.1018 0.933 1739670 Maybridge4_002115 O=C(C(C(=O)N1CCCCC1)C2(CC3CC4CC(C3)C2)C4)N5CCCCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A04 compound treatment 87960.0 17700.0 0.29 164280.0 51200.0 0.82 0.7839 0.9041 3178238 Maybridge4_002116 CSc1c(C#N)c(nn1C)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A05 compound treatment 168800.0 98500.0 1.63 253040.0 140000.0 2.23 2.7278 0.988 3063681 Maybridge4_002117 CN(C)c1nc(O)nc(n1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A06 compound treatment 78160.0 7910.0 0.13 95800.0 -17300.0 -0.28 -0.1023 -0.3359 3178239 Maybridge4_002118 CN1c2ccccc2C(=O)/C(=C\Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)/S1(=O)=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A07 compound treatment 169760.0 99500.0 1.64 175040.0 62000.0 0.99 1.86 0.9704 1532269 Maybridge4_002119 COc1cc2CCN=C(c3ccccc3NC(=O)c4cccc(Cl)c4)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A08 compound treatment 33040.0 -37200.0 -0.61 43640.0 -69400.0 -1.11 -1.2168 -0.9615 1424615 Maybridge4_002120 CCCS(=O)(=O)C1=C(N)OC(=C(C#N)C1c2ccc(Cl)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A09 compound treatment 65200.0 -5060.0 -0.08 93960.0 -19100.0 -0.3 -0.2743 -0.8689 1227957 Maybridge4_002121 Cc1cc(N(S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)n(C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A10 compound treatment 10360.0 -59900.0 -0.99 10200.0 -103000.0 -1.64 -1.8584 -0.9707 3063685 Maybridge4_002122 CS/C(=C(/C#N)\C(=O)c1ccc(Cl)cc1)/NCC2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A11 compound treatment 215640.0 145000.0 2.4 209880.0 96800.0 1.54 2.7882 0.9772 1505422 Maybridge4_002123 O=C(Nc1cc(nn1c2ccccc2)C3CC3)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A12 compound treatment 213320.0 143000.0 2.36 230280.0 117000.0 1.87 2.991 0.9933 3063686 Maybridge4_002124 CC(C)S(=O)(=O)/C(=C/Nc1ncccn1)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A13 compound treatment 129400.0 59100.0 0.98 140720.0 27700.0 0.44 1.0021 0.9354 1730851 Maybridge4_002125 Cc1ccc(cc1)C2C(=C(N)OC(=C2C#N)C3CC3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A14 compound treatment 227280.0 157000.0 2.59 252920.0 140000.0 2.23 3.4091 0.9972 3063688 Maybridge4_002126 Cn1ccnc1S(=O)(=O)/C(=C/c2ccc3OCOc3c2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A15 compound treatment 174000.0 104000.0 1.71 216640.0 104000.0 1.65 2.3783 0.9998 1337308 Maybridge4_002127 CCOC(=O)c1cnc2n(C)nc(C3CC3)c2c1N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A16 compound treatment 9280.0 -61000.0 -1.01 16600.0 -96500.0 -1.54 -1.7989 -0.9789 3063690 Maybridge4_002128 Cc1cc(nc2c(Br)c(nn12)C(C)(C)C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A17 compound treatment 190480.0 120000.0 1.98 223200.0 110000.0 1.76 2.6446 0.9981 1574781 Maybridge4_002129 COc1c(Cl)scc1NC(=O)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A18 compound treatment 7120.0 -63100.0 -1.04 9280.0 -104000.0 -1.65 -1.9066 -0.9752 3063692 Maybridge4_002130 CSC(=C(C#N)C(=O)c1cccc(c1)C(F)(F)F)SC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A19 compound treatment 60600.0 -9660.0 -0.16 64080.0 -49000.0 -0.78 -0.6647 -0.8343 3178240 Maybridge4_002131 Clc1ccccc1C(=O)C(=C2SCCCS2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A20 compound treatment 117120.0 46900.0 0.77 188680.0 75600.0 1.21 1.3993 0.977 1150123 Maybridge4_002132 CC(C)CC(NC(=O)Cc1ccsc1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A21 compound treatment 75120.0 4870.0 0.08 98600.0 -14500.0 -0.23 -0.1062 -0.4351 3063728 Maybridge4_002133 COc1cccc(c1)c2nc(N)nc(SC)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A22 compound treatment 86240.0 16000.0 0.26 150200.0 37100.0 0.59 0.6051 0.9337 3178241 Maybridge4_002134 Fc1ccc(N/C=C(\C#N)/S(=O)(=O)Cc2ccco2)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A23 mock treatment 62600.0 -7660.0 -0.13 117280.0 4220.0 0.07 -0.0418 -0.2921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 A24 mock treatment 34280.0 -36000.0 -0.59 87840.0 -25200.0 -0.4 -0.7042 -0.9819 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B01 compound treatment 91200.0 20900.0 0.35 145960.0 32900.0 0.52 0.6153 0.9796 3178242 Maybridge4_002135 FC(F)(F)c1cc(CN/C=C(\C#N)/S(=O)(=O)Cc2ccco2)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B02 compound treatment 101120.0 30900.0 0.51 149080.0 36000.0 0.57 0.7662 0.9982 3063731 Maybridge4_002136 COC(=O)c1ccc2C(=O)/C(=C/Nc3ccc(Cl)cc3)/S(=O)(=O)N(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B03 compound treatment 98400.0 28100.0 0.46 148280.0 35200.0 0.56 0.7254 0.9956 3178243 Maybridge4_002137 CSc1sc(/C(=N\O)/C)c2CC(C)(C)C/C(=N/O)/c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B04 compound treatment 142960.0 72700.0 1.2 156400.0 43300.0 0.69 1.3371 0.9656 3063732 Maybridge4_002138 COC(=O)c1sc(SC)c(c1C)c2ccon2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B05 compound treatment 154440.0 84200.0 1.39 185440.0 72400.0 1.15 1.7984 0.9957 3178244 Maybridge4_002139 Clc1ccc(Sc2ccccc2CN/C(=C(\N=C\c3cccs3)/C#N)/C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B06 compound treatment 31480.0 -38800.0 -0.64 39160.0 -73900.0 -1.18 -1.2855 -0.9589 3063733 Maybridge4_002140 CN(C)/C=C/C(=O)c1ccc2OC(C)(C)CCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B07 compound treatment 104480.0 34200.0 0.56 109560.0 -3500.0 -0.06 0.36 0.6342 1330787 Maybridge4_002141 Clc1ccc(cc1)C(=O)N(CCS(=O)(=O)c2ccc(Cl)cc2)Cc3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B08 compound treatment 85240.0 15000.0 0.25 108440.0 -4620.0 -0.07 0.1228 0.4759 3063734 Maybridge4_002142 Clc1ccc(cc1)S(=O)(=O)C(=C2SCCCCS2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B09 compound treatment 201400.0 131000.0 2.16 170200.0 57100.0 0.91 2.1747 0.926 1191188 Maybridge4_002143 CSc1scc2CCc3cn(nc3-c12)C(=O)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B10 compound treatment 172800.0 103000.0 1.69 202800.0 89700.0 1.43 2.2083 0.9965 1483249 Maybridge4_002144 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)S(=O)(=O)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B11 compound treatment 89560.0 19300.0 0.32 83200.0 -29900.0 -0.48 -0.1112 -0.1942 3178245 Maybridge4_002145 Cc1csc2sc(C(=O)c3ccc(Cl)cc3)c(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B12 compound treatment 105280.0 35000.0 0.58 98480.0 -14600.0 -0.23 0.2445 0.3924 3063735 Maybridge4_002146 FC(F)(F)c1cc(n2ncc(C(=O)NC(=S)Nc3ccccc3Cl)c2n1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B13 compound treatment 116280.0 46000.0 0.76 136600.0 23500.0 0.38 0.8025 0.9471 1629969 Maybridge4_002147 CCOC(=O)c1sc(SC)c-2c1CCc3cnc(SC)nc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B14 compound treatment 47920.0 -22300.0 -0.37 57440.0 -55600.0 -0.89 -0.8876 -0.9244 3178246 Maybridge4_002148 CC(C)CSc1nnc(CSCc2nc(cs2)c3ccc(Cl)cc3)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B15 compound treatment 79120.0 8870.0 0.15 109120.0 -3940.0 -0.06 0.0591 0.3708 1122221 Maybridge4_002149 Clc1ccc(cc1)C2CC(=CC(=S)S2)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B16 compound treatment 138720.0 68500.0 1.13 158600.0 45500.0 0.73 1.3124 0.9771 3063769 Maybridge4_002150 NNC(=O)c1ccc(CSc2ccc(cn2)C(F)(F)F)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B17 compound treatment 62520.0 -7740.0 -0.13 98760.0 -14300.0 -0.23 -0.2515 -0.9625 3178247 Maybridge4_002151 COC(=O)C1=C(CSC1)Nc2ccc(OC(=O)Nc3ccc(OC(F)(F)F)cc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B18 compound treatment 102520.0 32300.0 0.53 121240.0 8180.0 0.13 0.4688 0.8549 3063773 Maybridge4_002152 CC(C)(C)SC(=O)c1cccnc1SCCS(=O)(=O)c2cccc(c2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B19 compound treatment 151080.0 80800.0 1.33 181880.0 68800.0 1.1 1.719 0.9953 3178248 Maybridge4_002153 Cc1csc2sc(/C=N/Cc3cccs3)c(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B20 compound treatment 5880.0 -64400.0 -1.06 8080.0 -105000.0 -1.67 -1.9346 -0.976 1206852 Maybridge4_002154 CCOC(=O)c1cnc2n(C)nc(C)c2c1Sc3nnc(SC)s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B21 compound treatment 35080.0 -35200.0 -0.58 50240.0 -62800.0 -1.0 -1.1186 -0.9664 3178249 Maybridge4_002155 CS(=O)(=O)c1sc(C(=O)NC(=S)Nc2ccc(OC(F)(F)F)cc2)c3CCC=Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B22 compound treatment 31560.0 -38700.0 -0.64 52360.0 -60700.0 -0.97 -1.1358 -0.9797 3178341 Maybridge4_002156 CCOC(=O)CC1Sc2ccccc2N=C1SCC(=O)Nc3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B23 mock treatment 118200.0 47900.0 0.79 178360.0 65300.0 1.04 1.2956 0.9909 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 B24 mock treatment 102440.0 32200.0 0.53 116960.0 3900.0 0.06 0.4196 0.7845 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C01 compound treatment 76240.0 5990.0 0.1 99920.0 -13100.0 -0.21 -0.0782 -0.3379 3063777 Maybridge4_002157 CCN(CC)C(=S)NC(=S)c1ccc(C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C02 compound treatment 109480.0 39200.0 0.65 138920.0 25900.0 0.41 0.7493 0.9762 3178342 Maybridge4_002158 COC(=O)c1ccccc1S(=O)(=O)/C(=C/Nc2nc(C)cc(C)n2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C03 compound treatment 100680.0 30400.0 0.5 138760.0 25700.0 0.41 0.6448 0.9949 1199477 Maybridge4_002159 CN(C1CCS(=O)(=O)C1)C(=O)COc2ccc(Oc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C04 compound treatment 15600.0 -54700.0 -0.9 20600.0 -92500.0 -1.47 -1.68 -0.9723 3178343 Maybridge4_002160 CSc1c(C#N)c(nn1C(=O)C(C)(C)C)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C05 compound treatment 108280.0 38000.0 0.63 142360.0 29300.0 0.47 0.774 0.9894 3063778 Maybridge4_002161 CS/C(=N/C(=N)Nc1ccc(Cl)cc1)/N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C06 compound treatment 73440.0 3190.0 0.05 93200.0 -19900.0 -0.32 -0.1867 -0.5817 3178344 Maybridge4_002162 Cc1c(csc1C(=O)Nc2ccc(F)cc2F)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C07 compound treatment 135000.0 64700.0 1.07 152080.0 39000.0 0.62 1.1955 0.9668 1368486 Maybridge4_002163 OC(=O)c1ccccc1SCC(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C08 compound treatment 146800.0 76500.0 1.26 154040.0 41000.0 0.65 1.3553 0.9528 3178345 Maybridge4_002164 CNC(=S)Nc1cscc1S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C09 compound treatment 59400.0 -10900.0 -0.18 64080.0 -49000.0 -0.78 -0.6787 -0.8474 3063810 Maybridge4_002165 Clc1cccc(NC(=S)NC(C#N)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C10 compound treatment 186680.0 116000.0 1.92 177080.0 64000.0 1.02 2.0805 0.9561 3178346 Maybridge4_002166 CN(C)/C=C/C(=O)c1cnc2cc(C)nn2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C11 compound treatment 141200.0 70900.0 1.17 157920.0 44900.0 0.71 1.3337 0.972 1175106 Maybridge4_002167 Cc1c(nnc2cc(nn12)c3ccccc3)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C12 compound treatment 152720.0 82500.0 1.36 154800.0 41700.0 0.67 1.433 0.9458 3178347 Maybridge4_002168 COC(=O)c1scc(c1n2cccc2)S(=O)(=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C13 compound treatment 87880.0 17600.0 0.29 148640.0 35600.0 0.57 0.6067 0.9519 1474680 Maybridge4_002169 NC1=C(C#N)C(C(=C(O1)C2CC2)C#N)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C14 compound treatment 130480.0 60200.0 0.99 153800.0 40700.0 0.65 1.1621 0.9787 1123050 Maybridge4_002170 CC(C)S(=O)(=O)c1cscc1NC(=O)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C15 compound treatment 139800.0 69500.0 1.15 160200.0 47100.0 0.75 1.343 0.9789 1443948 Maybridge4_002171 O=c1c2CSCc2[nH]c3cc(nn13)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C16 compound treatment 11280.0 -59000.0 -0.97 13000.0 -100000.0 -1.59 -1.8161 -0.972 3063812 Maybridge4_002172 CC(C)S(=O)(=O)c1csc(NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C17 compound treatment 157960.0 87700.0 1.45 179000.0 65900.0 1.05 1.7669 0.9876 1153510 Maybridge4_002173 COc1c(Cl)scc1NC(=O)N2CC(C)OC(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C18 compound treatment 137840.0 67600.0 1.12 163440.0 50400.0 0.8 1.3567 0.987 3063813 Maybridge4_002174 CS(=O)(=O)c1scc(c1C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C19 compound treatment 61760.0 -8500.0 -0.14 83760.0 -29300.0 -0.47 -0.4294 -0.8806 3178348 Maybridge4_002175 CC(C)(C)c1ccc(cc1)c2n[nH]c(c2C#N)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C20 compound treatment 7160.0 -63100.0 -1.04 10080.0 -103000.0 -1.64 -1.8971 -0.9759 3178349 Maybridge4_002176 Cn1nc(cc1C(F)(F)F)c2ccc(s2)C(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C21 compound treatment 80120.0 9870.0 0.16 141120.0 28100.0 0.45 0.4314 0.9064 3063814 Maybridge4_002177 COC(=O)c1sc(SC)c(C#N)c1c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C22 compound treatment 47360.0 -22900.0 -0.38 70560.0 -42500.0 -0.68 -0.7462 -0.962 3178350 Maybridge4_002178 CCN(CCS(=O)(=O)c1ccc(C)cc1)C(=O)c2ccc(s2)c3cc(nn3C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C23 mock treatment 97800.0 27500.0 0.45 130240.0 17200.0 0.27 0.5151 0.9705 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 C24 mock treatment 88240.0 18000.0 0.3 125840.0 12800.0 0.2 0.3539 0.9831 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D01 compound treatment 89880.0 19600.0 0.32 113440.0 379.0 0.01 0.2333 0.7202 3063815 Maybridge4_002179 Nc1nc(ncc1S(=O)(=O)Cc2ccco2)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D02 compound treatment 112320.0 42100.0 0.69 147720.0 34700.0 0.55 0.8816 0.9936 3063818 Maybridge4_002180 CC(C)(C)S(=O)(=O)c1cnc(nc1N)c2cnccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D03 compound treatment 9440.0 -60800.0 -1.0 14480.0 -98600.0 -1.57 -1.8209 -0.9766 3178351 Maybridge4_002181 Cc1csc2sc(COC(=O)Nc3ccccc3)c(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D04 compound treatment 61760.0 -8500.0 -0.14 77480.0 -35600.0 -0.57 -0.5002 -0.8562 3178352 Maybridge4_002182 CSc1sc(C(=O)NN)c2CCCC3(SCCS3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D05 compound treatment 93920.0 23700.0 0.39 110880.0 -2180.0 -0.03 0.2516 0.6416 3063851 Maybridge4_002183 CCOC(=O)c1sc(c2/C(=N\O)/CC(C)(C)Cc12)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D06 compound treatment 41400.0 -28900.0 -0.48 44000.0 -69100.0 -1.1 -1.1151 -0.9298 3178353 Maybridge4_002184 Cc1ccc(cc1)S(=O)(=O)CCSc2sc(C#N)c3CC(C)(C)CC(=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D07 compound treatment 168400.0 98100.0 1.62 157800.0 44700.0 0.71 1.6498 0.932 1145089 Maybridge4_002185 CSc1sc(C(=O)O)c-2c1S(=O)(=O)N(C)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D08 compound treatment 38840.0 -31400.0 -0.52 38560.0 -74500.0 -1.19 -1.2063 -0.931 3178354 Maybridge4_002186 FC(F)(F)c1cccc(c1)C(=O)C(=C2SCCCCS2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D09 compound treatment 80800.0 10500.0 0.17 97720.0 -15300.0 -0.24 -0.0498 -0.166 3063853 Maybridge4_002187 Cn1nc(cc1C(F)(F)F)c2ccc(s2)S(=O)(=O)NCc3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D10 compound treatment 115200.0 44900.0 0.74 130440.0 17400.0 0.28 0.7205 0.9098 3178355 Maybridge4_002188 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)S(=O)(=O)c4cccc(c4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D11 compound treatment 42840.0 -27400.0 -0.45 43720.0 -69300.0 -1.11 -1.1015 -0.9223 3063854 Maybridge4_002189 CSc1sc(cc1S(=O)(=O)C(C)C)C(=O)Sc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D12 compound treatment 171120.0 101000.0 1.67 175080.0 62000.0 0.99 1.8763 0.969 3178356 Maybridge4_002190 CC1(C)CCc2cc(ccc2O1)c3ccnc(S)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D13 compound treatment 19080.0 -51200.0 -0.84 20120.0 -92900.0 -1.48 -1.6448 -0.9645 3063856 Maybridge4_002191 Cc1c(Br)sc2sc(c(C)c12)c3nn(C)cc3Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D14 compound treatment 10640.0 -59600.0 -0.98 11720.0 -101000.0 -1.62 -1.838 -0.9718 3178357 Maybridge4_002192 CSc1sc(Cl)c2CC(C)(C)C/C(=N/O)/c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D15 compound treatment 27160.0 -43100.0 -0.71 29320.0 -83700.0 -1.33 -1.4468 -0.9566 3178358 Maybridge4_002193 CC(C)NC(=O)CSc1nccc(n1)c2sc3sc(Br)c(C)c3c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D16 compound treatment 145280.0 75000.0 1.24 169920.0 56900.0 0.91 1.5165 0.9882 3063857 Maybridge4_002194 Sc1nccc(n1)c2ccc3OCCc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D17 compound treatment 124200.0 53900.0 0.89 131280.0 18200.0 0.29 0.835 0.8915 3063858 Maybridge4_002195 COc1ccc(CSc2nnc(CSc3cccs3)n2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D18 compound treatment 163160.0 92900.0 1.53 161600.0 48500.0 0.77 1.6315 0.9498 3178359 Maybridge4_002196 CS(=O)(=NS(=O)(=O)c1cccc2nsnc12)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D19 compound treatment 152360.0 82100.0 1.36 174720.0 61700.0 0.98 1.6533 0.9875 3178360 Maybridge4_002197 Cc1cc2ncc(c(C)n2n1)c3ccnc(SCCS(=O)(=O)c4ccccc4)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D20 compound treatment 108200.0 37900.0 0.63 126920.0 13900.0 0.22 0.5991 0.902 3063859 Maybridge4_002198 CC(C)C1Oc2c(cccc2N(CC(=O)O)C1=S)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D21 compound treatment 79920.0 9670.0 0.16 122640.0 9580.0 0.15 0.2208 0.9998 3178361 Maybridge4_002199 CSc1nc(nc(c1C#N)c2ccc(OC(F)(F)F)cc2)c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D22 compound treatment 32480.0 -37800.0 -0.62 53400.0 -59700.0 -0.95 -1.1133 -0.9791 1139728 Maybridge4_002200 CCOC(=O)CC1Sc2ccccc2N=C1SCCS(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D23 mock treatment 103560.0 33300.0 0.55 157240.0 44200.0 0.7 0.8867 0.9925 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 D24 mock treatment 84320.0 14100.0 0.23 101960.0 -11100.0 -0.18 0.0391 0.1338 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E01 compound treatment 65040.0 -5220.0 -0.09 80600.0 -32500.0 -0.52 -0.4267 -0.8136 1149948 Maybridge4_002201 Clc1ccc(cc1)N2CCN(CC2)C3=Cc4ccccc4C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E02 compound treatment 83200.0 12900.0 0.21 157480.0 44400.0 0.71 0.6517 0.8813 3178362 Maybridge4_002202 COC(=O)c1ccccc1S(=O)(=O)/C(=C/Nc2nc(SC)nc(n2)C3CC3)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E03 compound treatment 77080.0 6830.0 0.11 113240.0 179.0 0.0 0.0817 0.7248 3063320 Maybridge4_002203 CSc1nc(N)n(n1)c2cc(Cl)cc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E04 compound treatment 24280.0 -46000.0 -0.76 28040.0 -85000.0 -1.36 -1.4948 -0.9625 3178363 Maybridge4_002204 CSc1n[nH]c(NC(=O)c2ccccc2Cl)c1S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E05 compound treatment 52320.0 -17900.0 -0.3 62680.0 -50400.0 -0.8 -0.7772 -0.9081 1032087 Maybridge4_002205 Oc1ccnc(SCc2ccc(Cl)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E06 compound treatment 152080.0 81800.0 1.35 161280.0 48200.0 0.77 1.4985 0.9643 3178364 Maybridge4_002206 CN1c2ccccc2C(=O)/C(=C\Nc3ncccn3)/S1(=O)=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E07 compound treatment 137840.0 67600.0 1.12 129360.0 16300.0 0.26 0.9726 0.849 3063324 Maybridge4_002207 CCN(CCC#N)C(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E08 compound treatment 145320.0 75100.0 1.24 158600.0 45500.0 0.73 1.3894 0.9675 1520456 Maybridge4_002208 CCOC(=O)NS(=O)(=O)c1ccccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E09 compound treatment 63680.0 -6580.0 -0.11 68880.0 -44200.0 -0.7 -0.5747 -0.8066 1248613 Maybridge4_002209 O=c1cc([nH]c2cc(nn12)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E10 compound treatment 155080.0 84800.0 1.4 174120.0 61100.0 0.97 1.6783 0.9842 3178365 Maybridge4_002210 Cc1cccc(c1)c2n[nH]c(c2C#N)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E11 compound treatment 98600.0 28300.0 0.47 95280.0 -17800.0 -0.28 0.1305 0.2385 1374930 Maybridge4_002211 COc1cccc(c1)c2c(nnc3cc(nn23)c4ccccc4)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E12 compound treatment 124920.0 54700.0 0.9 126240.0 13200.0 0.21 0.7866 0.849 1289071 Maybridge4_002212 Clc1ccc(cc1)S(=O)(=O)CCSc2ccccc2NC(=O)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E13 compound treatment 137840.0 67600.0 1.12 154600.0 41500.0 0.66 1.257 0.969 1391332 Maybridge4_002213 COc1ccc(cc1)C2C(=C(N)OC(=C2C#N)C3CC3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E14 compound treatment 128840.0 58600.0 0.97 140000.0 26900.0 0.43 0.9874 0.9332 3063326 Maybridge4_002214 Cc1nccc(n1)c2cccc(NS(=O)(=O)c3ccccc3C(F)(F)F)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E15 compound treatment 159880.0 89600.0 1.48 166280.0 53200.0 0.85 1.6459 0.9651 3178456 Maybridge4_002215 Cn1nc(cc1N)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E16 compound treatment 144560.0 74300.0 1.23 154920.0 41900.0 0.67 1.3391 0.959 1540260 Maybridge4_002216 CC(C)S(=O)(=O)c1csc(NC(=O)N2CCCCC2)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E17 compound treatment 125240.0 55000.0 0.91 156200.0 43100.0 0.69 1.128 0.9906 1698879 Maybridge4_002217 Nc1nc(ncc1S(=O)(=O)c2ccc(Cl)cc2)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E18 compound treatment 34080.0 -36200.0 -0.6 41080.0 -72000.0 -1.15 -1.2335 -0.9537 1598720 Maybridge4_002218 Clc1ccc(cc1)c2csc(S(=O)C3CCCCC3)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E19 compound treatment 166600.0 96300.0 1.59 151160.0 38100.0 0.61 1.554 0.9128 1438402 Maybridge4_002219 O=C(c1ccccc1)c2cnc3ccccn3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E20 compound treatment 106440.0 36200.0 0.6 134480.0 21400.0 0.34 0.6638 0.9648 3178457 Maybridge4_002220 CN(C)c1scc(c1C#N)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E21 compound treatment 46160.0 -24100.0 -0.4 71360.0 -41700.0 -0.66 -0.7512 -0.9699 3178458 Maybridge4_002221 Cc1ccc(cc1)S(=O)(=O)/C(=C/Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E22 compound treatment 122920.0 52700.0 0.87 164720.0 51700.0 0.82 1.1969 0.9996 1367919 Maybridge4_002222 O=S(=O)(Cc1ccco1)Cc2nc(cs2)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E23 mock treatment 88440.0 18200.0 0.3 124360.0 11300.0 0.18 0.3396 0.9701 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 E24 mock treatment 102040.0 31800.0 0.52 119840.0 6780.0 0.11 0.4474 0.8352 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F01 compound treatment 81240.0 11000.0 0.18 123600.0 10500.0 0.17 0.247 0.9993 3063357 Maybridge4_002223 CNC(=O)c1cc(C#N)c(SC)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F02 compound treatment 74360.0 4110.0 0.07 87720.0 -25300.0 -0.4 -0.2377 -0.5804 3178459 Maybridge4_002224 CSc1scc2CCc3cnc(SCC(=O)c4ccc(Cl)cc4)nc3-c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F03 compound treatment 54760.0 -15500.0 -0.26 91160.0 -21900.0 -0.35 -0.4277 -0.9883 3063358 Maybridge4_002225 Cc1csc2sc(C(=O)Oc3ccc(Cl)cc3)c(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F04 compound treatment 69320.0 -935.0 -0.02 129800.0 16700.0 0.27 0.1777 0.6651 3178460 Maybridge4_002226 Nc1nc(ncc1S(=O)(=O)c2ccc(cn2)C(F)(F)F)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F05 compound treatment 48240.0 -22000.0 -0.36 59000.0 -54100.0 -0.86 -0.8662 -0.9263 3063359 Maybridge4_002227 CSc1sc(cc1c2nc(C)cs2)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F06 compound treatment 49000.0 -21300.0 -0.35 48960.0 -64100.0 -1.02 -0.9705 -0.8984 3178461 Maybridge4_002228 CC(C)S(=O)(=O)c1cscc1NC(=O)c2ccc(s2)c3cc(nn3C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F07 compound treatment 142760.0 72500.0 1.2 150360.0 37300.0 0.59 1.2667 0.9478 1693988 Maybridge4_002229 CS(=O)(=O)c1sc(C(=O)Nc2ccccc2Cl)c3CCC=Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F08 compound treatment 76160.0 5910.0 0.1 97360.0 -15700.0 -0.25 -0.108 -0.4022 3178462 Maybridge4_002230 CSc1sc(c2ccon2)c(c1C#N)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F09 compound treatment 11080.0 -59200.0 -0.98 11680.0 -101000.0 -1.62 -1.8333 -0.9709 3178463 Maybridge4_002231 CC1(C)CC(=O)C=C(SCC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F10 compound treatment 150800.0 80500.0 1.33 167240.0 54200.0 0.86 1.5508 0.9782 3063360 Maybridge4_002232 FC(F)(F)c1ccc(nc1)S(=O)(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F11 compound treatment 154840.0 84600.0 1.4 176680.0 63600.0 1.01 1.7043 0.9877 3178464 Maybridge4_002233 CS(=O)(=NS(=O)(=O)c1ccc(s1)c2ccccn2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F12 compound treatment 12120.0 -58100.0 -0.96 13040.0 -100000.0 -1.59 -1.8058 -0.9705 3063362 Maybridge4_002234 C/S(=N\C(=O)Nc1ccc(Cl)cc1)/c2sc(Cl)c3CCCC(=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F13 compound treatment 150560.0 80300.0 1.33 168880.0 55800.0 0.89 1.5664 0.9812 3178465 Maybridge4_002235 CS(=O)(=NC(=S)NC(=O)Oc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F14 compound treatment 147360.0 77100.0 1.27 135280.0 22200.0 0.35 1.1504 0.8708 3063392 Maybridge4_002236 FC(F)(F)c1cnc(N2CCS(=NC(=O)c3ccccc3)CC2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F15 compound treatment 30880.0 -39400.0 -0.65 32240.0 -80800.0 -1.29 -1.3705 -0.9498 3178466 Maybridge4_002237 Cc1c(Br)sc2sc(c(C)c12)c3ccnc(SCC(=O)NCC=C)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F16 compound treatment 69480.0 -775.0 -0.01 86800.0 -26300.0 -0.42 -0.305 -0.7284 1201268 Maybridge4_002238 C(Sc1nccc(n1)c2ccc3OCCc3c2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F17 compound treatment 24440.0 -45800.0 -0.76 32840.0 -80200.0 -1.28 -1.4389 -0.9686 1378146 Maybridge4_002239 CS(=O)(=O)c1sc(NC(=O)Nc2ccc(Cl)cc2)c3CCC=Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F18 compound treatment 28600.0 -41700.0 -0.69 31560.0 -81500.0 -1.3 -1.4048 -0.9558 1406686 Maybridge4_002240 Cc1nn(Cc2cccc(c2)C(=O)NC(=O)Nc3ccc(Cl)cc3)c(C)c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F19 compound treatment 60000.0 -10300.0 -0.17 64440.0 -48600.0 -0.77 -0.6677 -0.8417 1721379 Maybridge4_002241 O=S(=O)(N1CCCCC1)c2ccc(s2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F20 compound treatment 115240.0 45000.0 0.74 126600.0 13500.0 0.22 0.6777 0.8763 3063394 Maybridge4_002242 CN(C)/C=C\1/C(=O)c2sccc2N(C)S1(=O)=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F21 compound treatment 116880.0 46600.0 0.77 150640.0 37600.0 0.6 0.9677 0.9923 3178467 Maybridge4_002243 CSc1sc(c(C)c1c2ccnc(S)n2)c3nc(C)cs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F22 compound treatment 97480.0 27200.0 0.45 150040.0 37000.0 0.59 0.7345 0.991 1422989 Maybridge4_002244 Clc1ccc(OC(=O)c2csc(n2)C3COc4ccccc4O3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F23 mock treatment 82240.0 12000.0 0.2 121560.0 8500.0 0.14 0.2357 0.9829 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 F24 mock treatment 82240.0 12000.0 0.2 138720.0 25700.0 0.41 0.4291 0.9445 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G01 compound treatment 5120.0 -65100.0 -1.08 10880.0 -102000.0 -1.63 -1.9119 -0.9797 1651892 Maybridge4_002245 CCCCC1(Cc2ccccc2)C(=O)Nc3ccccc3C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G02 compound treatment 55240.0 -15000.0 -0.25 129120.0 16100.0 0.26 0.0057 0.0161 3178468 Maybridge4_002246 CSc1nc(N/C=C(\C#N)/S(=O)(=O)c2ccccc2Cl)nc(n1)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G03 compound treatment 43440.0 -26800.0 -0.44 73320.0 -39700.0 -0.63 -0.7609 -0.9846 3063398 Maybridge4_002247 CC(=N)NC(=S)Nc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G04 compound treatment 135040.0 64800.0 1.07 142680.0 29600.0 0.47 1.09 0.9324 3178469 Maybridge4_002248 CSc1n[nH]c(NC(=O)Nc2ccccc2)c1S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G05 compound treatment 104120.0 33900.0 0.56 98480.0 -14600.0 -0.23 0.231 0.3815 3063400 Maybridge4_002249 CN(C)C(=O)Oc1ccnc(SCc2c(F)cccc2Cl)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G06 compound treatment 96600.0 26300.0 0.43 99080.0 -14000.0 -0.22 0.1499 0.3068 3178470 Maybridge4_002250 COc1ccc(cc1)c2n[nH]c(SC)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G07 compound treatment 143160.0 72900.0 1.2 144000.0 30900.0 0.49 1.1997 0.9224 3063401 Maybridge4_002251 Cc1ccc(COc2ccc(I)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G08 compound treatment 40320.0 -29900.0 -0.49 48880.0 -64200.0 -1.02 -1.0727 -0.9443 3178471 Maybridge4_002252 CSc1sc(C(=O)Nc2cccc(Cl)c2)c(c1C#N)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G09 compound treatment 133120.0 62900.0 1.04 143520.0 30500.0 0.49 1.0771 0.9401 1687124 Maybridge4_002253 CCN(CCS(=O)(=O)c1ccccc1)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G10 compound treatment 142520.0 72300.0 1.19 150160.0 37100.0 0.59 1.2616 0.9476 3178472 Maybridge4_002254 COC(=O)c1scc(c1N)S(=O)(=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G11 compound treatment 112760.0 42500.0 0.7 125480.0 12400.0 0.2 0.6361 0.8725 1226475 Maybridge4_002255 NC(=O)c1nnc2cc(nn2c1N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G12 compound treatment 41520.0 -28700.0 -0.47 39760.0 -73300.0 -1.17 -1.1615 -0.9212 1452741 Maybridge4_002256 Clc1ccc(cc1)S(=O)(=O)CCSc2ccccc2NC(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G13 compound treatment 83400.0 13100.0 0.22 91920.0 -21100.0 -0.34 -0.0848 -0.2117 3063431 Maybridge4_002257 Fc1cccc(Cl)c1CN/C(=C(\N=C\c2cccs2)/C#N)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G14 compound treatment 137600.0 67300.0 1.11 145200.0 32100.0 0.51 1.1483 0.9381 3178473 Maybridge4_002258 Clc1cccc(Cl)c1CSc2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G15 compound treatment 133240.0 63000.0 1.04 148120.0 35100.0 0.56 1.1303 0.9576 3178474 Maybridge4_002259 COc1ccc(/C=C(\C#N)/S(=O)(=O)c2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G16 compound treatment 10080.0 -60200.0 -0.99 10720.0 -102000.0 -1.63 -1.8558 -0.9717 1133071 Maybridge4_002260 CNC(=O)Nc1ccccc1NC2=C(CSC2)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G17 compound treatment 115040.0 44800.0 0.74 132280.0 19200.0 0.31 0.7393 0.9239 3178475 Maybridge4_002261 CC1CN(CC(C)O1)/C=C(\C#N)/S(=O)(=O)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G18 compound treatment 138960.0 68700.0 1.13 144760.0 31700.0 0.51 1.1592 0.9337 3063432 Maybridge4_002262 CS(=O)(=NS(=O)(=O)c1ccccc1C(F)(F)F)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G19 compound treatment 144000.0 73700.0 1.22 147160.0 34100.0 0.54 1.2451 0.9339 1259331 Maybridge4_002263 COCc1cc(O)nc2n(C)nc(c3cccs3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G20 compound treatment 127160.0 56900.0 0.94 157440.0 44400.0 0.71 1.1644 0.9902 3063433 Maybridge4_002264 CS/C(=C(/C#N)\S(=O)(=O)C(C)C)/N1CCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G21 compound treatment 132400.0 62100.0 1.03 150200.0 37100.0 0.59 1.1439 0.9659 3178476 Maybridge4_002265 CSc1c(C#N)c(nn1CC(=O)NN)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G22 compound treatment 112120.0 41900.0 0.69 127760.0 14700.0 0.23 0.6543 0.8967 3063434 Maybridge4_002266 Cc1onc(c1C(=O)N=S(=O)(C)C)c2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G23 mock treatment 90560.0 20300.0 0.34 112040.0 -1020.0 -0.02 0.2255 0.672 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 G24 mock treatment 67040.0 -3220.0 -0.05 94320.0 -18700.0 -0.3 -0.2487 -0.8199 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H01 compound treatment 29160.0 -41100.0 -0.68 56200.0 -56900.0 -0.91 -1.1205 -0.9898 3178477 Maybridge4_002267 CCOC(=O)c1sc(SCc2ccccc2)c(c1n3cccc3)S(=O)(=O)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H02 compound treatment 34720.0 -35500.0 -0.59 35640.0 -77400.0 -1.23 -1.2873 -0.9422 1259984 Maybridge4_002268 CSc1scc2CCc3cnc(SCC(=O)C(C)(C)C)nc3-c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H03 compound treatment 109880.0 39600.0 0.65 144440.0 31400.0 0.5 0.8162 0.9912 3063436 Maybridge4_002269 CSc1sc(cc1S(=O)(=O)C(C)C)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H04 compound treatment 119160.0 48900.0 0.81 144120.0 31100.0 0.5 0.9209 0.9724 3178558 Maybridge4_002270 COC(=O)c1sc(SCCOC(=O)c2ccccc2Cl)c3C(=O)CC(C)(C)Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H05 compound treatment 67440.0 -2820.0 -0.05 83480.0 -29600.0 -0.47 -0.3662 -0.7731 3063438 Maybridge4_002271 CSc1sc(C#N)c(C)c1c2ccn(n2)C(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H06 compound treatment 97760.0 27500.0 0.45 101280.0 -11800.0 -0.19 0.1883 0.3832 3178559 Maybridge4_002272 CSc1sc(C(=O)/C=C/N(C)C)c(c1C#N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H07 compound treatment 10360.0 -59900.0 -0.99 10160.0 -103000.0 -1.64 -1.8588 -0.9706 1222048 Maybridge4_002273 CS(=O)c1sc(C(=O)OCc2ccccc2)c3CC(C)(C)CC(=O)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H08 compound treatment 54480.0 -15800.0 -0.26 61840.0 -51200.0 -0.82 -0.7614 -0.8885 3178560 Maybridge4_002274 CSc1sc(c2cc[nH]n2)c(c1C#N)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H09 compound treatment 32000.0 -38300.0 -0.63 32120.0 -80900.0 -1.29 -1.3588 -0.946 3178561 Maybridge4_002275 CC1(C)CC(=O)C=C(SCc2c(Cl)cccc2Cl)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H10 compound treatment 112880.0 42600.0 0.7 132200.0 19100.0 0.31 0.7132 0.93 1307156 Maybridge4_002276 CC1(C)CCc2cc(ccc2O1)c3ccn(n3)C(=O)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H11 compound treatment 132360.0 62100.0 1.03 122400.0 9340.0 0.15 0.8302 0.8014 3063440 Maybridge4_002277 CSc1nnc(c2ccc(s2)S(=O)(=O)n3nc(C)cc3C)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H12 compound treatment 145040.0 74800.0 1.23 158880.0 45800.0 0.73 1.3893 0.9686 3178562 Maybridge4_002278 CCSc1nccc(n1)c2ccc3OC(C)(C)CCc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H13 compound treatment 74120.0 3870.0 0.06 85320.0 -27700.0 -0.44 -0.2675 -0.5989 3063442 Maybridge4_002279 Cc1csc2sc(c(C)c12)c3ccnc(SCc4ccccc4)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H14 compound treatment 148880.0 78600.0 1.3 144160.0 31100.0 0.5 1.2682 0.9128 3178563 Maybridge4_002280 CCOC(=O)c1sc(/S(=N/C(=O)Nc2ccccc2Cl)/C)c3C=CCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H15 compound treatment 119360.0 49100.0 0.81 127560.0 14500.0 0.23 0.7366 0.8739 1505800 Maybridge4_002281 COC(=O)C(CC(C)C)NS(=O)(=O)c1ccc(s1)c2nnc(SC)n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H16 compound treatment 86920.0 16700.0 0.28 100960.0 -12100.0 -0.19 0.0581 0.173 3178564 Maybridge4_002282 FC(F)(F)c1ccc(nc1)S(=O)(=O)CCSc2ncccc2C(=O)NCc3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H17 compound treatment 15440.0 -54800.0 -0.9 16840.0 -96200.0 -1.53 -1.7243 -0.9683 3178565 Maybridge4_002283 Clc1ccc(cc1)C2CC(=O)C=C(SCC(=O)c3ccccc3)S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H18 compound treatment 139800.0 69500.0 1.15 143640.0 30600.0 0.49 1.1564 0.9272 3063443 Maybridge4_002284 C/C(=N\O)/c1ccc2OCCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H19 compound treatment 154040.0 83800.0 1.38 161800.0 48700.0 0.78 1.5273 0.9628 3063445 Maybridge4_002285 CC1(C)CC(=O)c2c(SCC(=O)NN)sc(C#N)c2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H20 compound treatment 122840.0 52600.0 0.87 137640.0 24600.0 0.39 0.8908 0.9354 1254429 Maybridge4_002286 Cc1nn(C)c2ncc(C(=O)N)c(Oc3cccnc3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H21 compound treatment 38680.0 -31600.0 -0.52 42600.0 -70500.0 -1.12 -1.1627 -0.9391 3063446 Maybridge4_002287 CCOC(=O)c1sc(SC)c2c1CCCC32SCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H22 compound treatment 108480.0 38200.0 0.63 121720.0 8660.0 0.14 0.5438 0.8419 1921420 Maybridge4_002288 OC(=O)/C=C/1\OC(=O)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H23 mock treatment 125080.0 54800.0 0.91 150880.0 37800.0 0.6 1.0662 0.9805 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 H24 mock treatment 41280.0 -29000.0 -0.48 95720.0 -17300.0 -0.28 -0.5336 -0.966 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I01 compound treatment 25720.0 -44500.0 -0.74 70280.0 -42800.0 -0.68 -1.002 -0.9993 3178566 Maybridge4_002289 Cc1ccc(cc1)C(=O)OC[C@H]2O[C@@H](C[C@@H]2OC(=O)c3ccc(C)cc3)c4nnc5ncccn45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I02 compound treatment 7960.0 -62300.0 -1.03 16080.0 -97000.0 -1.55 -1.8201 -0.9804 3178567 Maybridge4_002290 FC(F)(F)c1cc(N/C=C(\C#N)/S(=O)(=O)Cc2ccc(Cl)cc2)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I03 compound treatment 87840.0 17600.0 0.29 113480.0 419.0 0.01 0.21 0.7232 3063447 Maybridge4_002291 CCOC(=O)c1c(C)noc1c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I04 compound treatment 87560.0 17300.0 0.29 75880.0 -37200.0 -0.59 -0.2171 -0.3299 3064096 Maybridge4_002292 CSc1sc(NC(=O)N2CCOCC2)c(c1C#N)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I05 compound treatment 117800.0 47500.0 0.78 145480.0 32400.0 0.52 0.9203 0.9794 3064097 Maybridge4_002293 CCOC(=O)/C=C/1\NC(=O)CS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I06 compound treatment 26320.0 -43900.0 -0.73 25640.0 -87400.0 -1.39 -1.4981 -0.9537 3064098 Maybridge4_002294 CSc1[nH]nc(c1C#N)c2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I07 compound treatment 149200.0 78900.0 1.3 138000.0 24900.0 0.4 1.2025 0.8826 3064099 Maybridge4_002295 Fc1ccc(NC(=S)N(CCC#N)CC2CCCO2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I08 compound treatment 135120.0 64900.0 1.07 147400.0 34300.0 0.55 1.1441 0.9515 3064100 Maybridge4_002296 CSc1sc(C(=O)O)c(C)c1S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I09 compound treatment 141120.0 70900.0 1.17 127080.0 14000.0 0.22 0.9852 0.8272 1242964 Maybridge4_002297 Cc1nn(c(NC(=O)c2ccccc2)c1C#N)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I10 compound treatment 135600.0 65300.0 1.08 146880.0 33800.0 0.54 1.1439 0.9486 3064101 Maybridge4_002298 CC(C)(C)S(=O)(=O)/C(=C/Nc1ccccn1)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I11 compound treatment 149680.0 79400.0 1.31 140040.0 27000.0 0.43 1.2311 0.8923 1003716 Maybridge4_002299 Cc1ccc(cc1)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I12 compound treatment 157400.0 87100.0 1.44 160400.0 47300.0 0.75 1.5507 0.9546 3064102 Maybridge4_002300 COC(=O)c1scc(c1/N=C/N(C)C)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I13 compound treatment 16200.0 -54100.0 -0.89 16640.0 -96400.0 -1.54 -1.7176 -0.9666 3178568 Maybridge4_002301 COc1cccc(c1)C(=O)/C=c/2\[nH]c(=O)\c(=C/c3cccs3)\s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I14 compound treatment 127960.0 57700.0 0.95 107400.0 -5660.0 -0.09 0.6098 0.6373 1621333 Maybridge4_002302 Cc1nccc(n1)c2cccc(NC(=O)Nc3ccccc3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I15 compound treatment 10160.0 -60100.0 -0.99 10480.0 -103000.0 -1.63 -1.8576 -0.9713 1156135 Maybridge4_002303 CC(C)(C)c1ccc(cc1)c2n[nH]c(NS(=O)(=O)c3ccccc3)c2Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I16 compound treatment 40000.0 -30300.0 -0.5 53920.0 -59100.0 -0.94 -1.0197 -0.9559 3064103 Maybridge4_002304 COC(=O)c1sc(SC)c(C#N)c1c2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I17 compound treatment 37000.0 -33300.0 -0.55 40400.0 -72700.0 -1.16 -1.2071 -0.9418 1665125 Maybridge4_002305 O=C(Nc1ccccc1)Nc2ccc(cc2)C3SCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I18 compound treatment 114200.0 43900.0 0.73 99560.0 -13500.0 -0.22 0.3608 0.4768 3064104 Maybridge4_002306 O=S(=O)(C(=C1SCCCS1)C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I19 compound treatment 112800.0 42500.0 0.7 86560.0 -26500.0 -0.42 0.1979 0.2415 3178569 Maybridge4_002307 CSc1nc2cc(C)nn2c(c1C#N)c3ccc(cc3)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I20 compound treatment 122600.0 52300.0 0.86 144120.0 31100.0 0.5 0.961 0.9651 3178570 Maybridge4_002308 Cc1ccc(cc1)S(=O)(=NC(=O)NC(=O)c2c(Cl)cccc2Cl)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I21 compound treatment 84880.0 14600.0 0.24 116640.0 3580.0 0.06 0.211 0.8508 3064105 Maybridge4_002309 CSc1nc(C)nc(N/C=C(\C#N)/S(=O)(=O)c2ccc(C)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I22 compound treatment 124720.0 54500.0 0.9 134680.0 21600.0 0.34 0.8794 0.9133 1118314 Maybridge4_002310 NNC(=O)c1csc(CS(=O)(=O)Cc2ccco2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I23 mock treatment 90160.0 19900.0 0.33 121680.0 8620.0 0.14 0.3295 0.9251 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 I24 mock treatment 40080.0 -30200.0 -0.5 90240.0 -22800.0 -0.36 -0.6094 -0.9881 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J01 compound treatment 13800.0 -56500.0 -0.93 43080.0 -70000.0 -1.12 -1.4477 -0.996 3064106 Maybridge4_002311 CSc1sc(c2n[nH]cc2Br)c3CC(C)(C)CC(=O)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J02 compound treatment 47560.0 -22700.0 -0.37 65800.0 -47300.0 -0.75 -0.7975 -0.948 3178571 Maybridge4_002312 CSc1scc2CCc3cnc(SCC(=O)NCC=C)nc3-c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J03 compound treatment 41200.0 -29100.0 -0.48 52600.0 -60500.0 -0.96 -1.0206 -0.9481 3064107 Maybridge4_002313 CSc1sc(C#N)c2CC(CC(=O)c12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J04 compound treatment 73560.0 3310.0 0.05 110280.0 -2780.0 -0.04 0.0072 0.1029 3178572 Maybridge4_002314 NC(=S)c1cnn2c(cc(nc12)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J05 compound treatment 110360.0 40100.0 0.66 134520.0 21500.0 0.34 0.71 0.9528 3064108 Maybridge4_002315 COC(=O)c1sccc1N/C=C(\C#N)/S(=O)(=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J06 compound treatment 108480.0 38200.0 0.63 118720.0 5660.0 0.09 0.51 0.8 3178573 Maybridge4_002316 CCOC(=O)c1sc(SC)c-2c1CCc3conc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J07 compound treatment 113280.0 43000.0 0.71 111000.0 -2060.0 -0.03 0.479 0.6737 3178574 Maybridge4_002317 Cc1nn(Cc2nnc(o2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c(C)c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J08 compound treatment 95880.0 25600.0 0.42 106720.0 -6340.0 -0.1 0.2276 0.5234 3064109 Maybridge4_002318 CCCS(=O)(=O)/C(=C/c1sccc1Oc2ccccc2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J09 compound treatment 69120.0 -1140.0 -0.02 68560.0 -44500.0 -0.71 -0.5148 -0.7255 3178575 Maybridge4_002319 Cc1ccc(cc1)S(=O)(=O)CCSC2=CC(=O)CC(C)(C)S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J10 compound treatment 53040.0 -17200.0 -0.28 61680.0 -51400.0 -0.82 -0.78 -0.8998 3064110 Maybridge4_002320 Clc1ccc(cc1)c2ccnc(SCCS(=O)(=O)c3ccc(Cl)cc3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J11 compound treatment 13800.0 -56500.0 -0.93 15000.0 -98100.0 -1.56 -1.7641 -0.9695 3178576 Maybridge4_002321 CSc1sc(C(=O)Sc2ccccc2)c-3c1S(=O)(=O)N(C)c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J12 compound treatment 139680.0 69400.0 1.15 153880.0 40800.0 0.65 1.2704 0.964 1454764 Maybridge4_002322 CCOC(=O)C1=C(Nc2ccc(OC(=O)C)cc2)C(=O)N(C1)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J13 compound treatment 81640.0 11400.0 0.19 84080.0 -29000.0 -0.46 -0.1937 -0.3885 3178577 Maybridge4_002323 Cc1csc2sc(c(C)c12)c3ccnc(SCC(=O)c4ccccc4)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J14 compound treatment 68080.0 -2180.0 -0.04 61280.0 -51800.0 -0.83 -0.609 -0.7372 3178578 Maybridge4_002324 CCOC(=O)c1sc(/S(=N/S(=O)(=O)c2cccc(Cl)c2)/C)c3C=CCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J15 compound treatment 105480.0 35200.0 0.58 113280.0 219.0 0.0 0.4136 0.7113 3064111 Maybridge4_002325 COc1cccc(NC(=S)N=S(=O)(C)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J16 compound treatment 104400.0 34100.0 0.56 132720.0 19700.0 0.31 0.6201 0.9616 3178579 Maybridge4_002326 CCCCc1ccc(NC(=O)N=S2CCN(CC2)c3ncc(cc3Cl)C(F)(F)F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J17 compound treatment 53360.0 -16900.0 -0.28 49400.0 -63700.0 -1.01 -0.9147 -0.8692 3064112 Maybridge4_002327 Cc1nn(Cc2nnc(SCc3c(Cl)cccc3Cl)o2)c(C)c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J18 compound treatment 65240.0 -5020.0 -0.08 78120.0 -34900.0 -0.56 -0.4523 -0.8034 3178580 Maybridge4_002328 C/S(=N/C(=O)Nc1ccc(Cl)cc1)/c2ccc(OC(=O)c3ccc(Cl)cc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J19 compound treatment 61280.0 -8980.0 -0.15 66240.0 -46800.0 -0.75 -0.6324 -0.8313 3064113 Maybridge4_002329 CS(=O)(=NS(=O)(=O)c1cc(cs1)S(=O)(=O)c2ccccc2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J20 compound treatment 88160.0 17900.0 0.3 72560.0 -40500.0 -0.65 -0.2475 -0.3486 1183286 Maybridge4_002330 CN1c2ccsc2-c3nc(SCc4ccc(Cl)cc4)ncc3S1(=O)=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J21 compound treatment 96640.0 26400.0 0.44 102600.0 -10500.0 -0.17 0.1901 0.4076 3064114 Maybridge4_002331 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)CCSc2ccc(cn2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J22 compound treatment 79800.0 9550.0 0.16 118960.0 5900.0 0.09 0.1779 0.9696 3178581 Maybridge4_002332 O=C(CCN1CCC(=N1)c2cccs2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J23 mock treatment 81640.0 11400.0 0.19 136320.0 23300.0 0.37 0.395 0.9504 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 J24 mock treatment 54440.0 -15800.0 -0.26 108240.0 -4820.0 -0.08 -0.2389 -0.878 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K01 compound treatment 20000.0 -50300.0 -0.83 49320.0 -63700.0 -1.02 -1.305 -0.9949 3064115 Maybridge4_002333 C/C(=C\C#N)/Nc1c(C)n(C)n(c2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K02 compound treatment 33280.0 -37000.0 -0.61 64000.0 -49100.0 -0.78 -0.9845 -0.9925 3178657 Maybridge4_002334 CSc1sc(C(=O)O)c(c1C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K03 compound treatment 61560.0 -8700.0 -0.14 115880.0 2820.0 0.04 -0.0697 -0.4636 1629094 Maybridge4_002335 NC(=S)NN1C2CSC1CS2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K04 compound treatment 86200.0 15900.0 0.26 89240.0 -23800.0 -0.38 -0.0824 -0.1783 3178658 Maybridge4_002336 CSc1c(C#N)c(nn1C(=O)c2cccs2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K05 compound treatment 92000.0 21700.0 0.36 113840.0 779.0 0.01 0.2626 0.7311 3178659 Maybridge4_002337 FC(F)(F)c1cccc(c1)S(=O)(=O)N2CCCN3C2c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K06 compound treatment 129680.0 59400.0 0.98 124960.0 11900.0 0.19 0.8277 0.8285 3064116 Maybridge4_002338 CSc1nc(/N=C/N(C)C)n2nc(cc2n1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K07 compound treatment 107080.0 36800.0 0.61 117720.0 4660.0 0.07 0.4823 0.7876 3178660 Maybridge4_002339 CN(CCC#N)C(=S)Nc1ccc(F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K08 compound treatment 103160.0 32900.0 0.54 111920.0 -1140.0 -0.02 0.3712 0.683 3064117 Maybridge4_002340 COC(=O)c1scc(C#N)c1/N=C/N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K09 compound treatment 79920.0 9670.0 0.16 120920.0 7860.0 0.13 0.2014 0.9928 1197958 Maybridge4_002341 CCN(CCS(=O)(=O)c1ccc(Cl)cc1)C(=O)Nc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K10 compound treatment 108160.0 37900.0 0.63 124000.0 10900.0 0.17 0.5657 0.871 1372972 Maybridge4_002342 COc1ncccc1C(=O)Nc2ccc(F)cc2F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K11 compound treatment 130320.0 60100.0 0.99 149640.0 36600.0 0.58 1.1134 0.968 3178661 Maybridge4_002343 CC(=O)Nc1c(Br)c(nn1c2ccccc2)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K12 compound treatment 133800.0 63500.0 1.05 142840.0 29800.0 0.47 1.0773 0.9357 3064118 Maybridge4_002344 O=S(=O)(/C(=C/c1ccc(\C=C(/C#N)\S(=O)(=O)c2ccccc2)cc1)/C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K13 compound treatment 141560.0 71300.0 1.18 146400.0 33300.0 0.53 1.208 0.9354 3178662 Maybridge4_002345 Oc1c2CN(C3CCCCC3)C(=O)c2nc4cc(nn14)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K14 compound treatment 109880.0 39600.0 0.65 111320.0 -1740.0 -0.03 0.4429 0.6765 1503351 Maybridge4_002346 CNC(=O)Nc1cccc(c1)c2ccnc(C)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K15 compound treatment 57880.0 -12400.0 -0.2 78080.0 -35000.0 -0.56 -0.5387 -0.9072 3178663 Maybridge4_002347 Clc1ccc(cc1)S(=O)(=O)/C(=C/c2ccccc2Cl)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K16 compound treatment 87800.0 17500.0 0.29 117760.0 4700.0 0.07 0.2577 0.8616 1326810 Maybridge4_002348 CC(C)S(=O)(=O)c1cnc(nc1N)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K17 compound treatment 69080.0 -1180.0 -0.02 81840.0 -31200.0 -0.5 -0.3656 -0.7341 3064119 Maybridge4_002349 CNC(=O)Nc1ccc(cc1)C2SCCS2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K18 compound treatment 60880.0 -9380.0 -0.15 58400.0 -54700.0 -0.87 -0.7255 -0.8199 1218060 Maybridge4_002350 CCOC(=O)c1cnc2c(csc2c1Sc3ccc(Cl)cc3)S(=O)(=O)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K19 compound treatment 47480.0 -22800.0 -0.38 82200.0 -30900.0 -0.49 -0.6137 -0.9912 3064120 Maybridge4_002351 CSc1nc2cc(C)nn2c(c3ccco3)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K20 compound treatment 37680.0 -32600.0 -0.54 59000.0 -54100.0 -0.86 -0.9895 -0.9742 1209169 Maybridge4_002352 CS(=O)N(C(=O)c1scc(c1C)S(=O)(=O)c2ccc(Cl)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K21 compound treatment 69320.0 -935.0 -0.02 95640.0 -17400.0 -0.28 -0.2073 -0.7453 1134325 Maybridge4_002353 COCc1cc(OC(=O)N(C)C)nc2n(C)nc(c3cccs3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K22 compound treatment 49800.0 -20500.0 -0.34 95600.0 -17500.0 -0.28 -0.4356 -0.9954 1310626 Maybridge4_002354 CCOC(=O)CSc1sc(C(=O)OCC)c-2c1S(=O)(=O)N(C)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K23 mock treatment 68440.0 -1820.0 -0.03 116600.0 3540.0 0.06 0.0187 0.2928 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 K24 mock treatment 40280.0 -30000.0 -0.49 75120.0 -37900.0 -0.6 -0.7775 -0.995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L01 compound treatment 19440.0 -50800.0 -0.84 32360.0 -80700.0 -1.29 -1.5027 -0.9785 3064121 Maybridge4_002355 CSc1sc(c2ccn(n2)C(=O)Nc3ccccc3)c4CC(C)(C)CC(=O)c14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L02 compound treatment 53080.0 -17200.0 -0.28 100400.0 -12700.0 -0.2 -0.3432 -0.9861 3178664 Maybridge4_002356 CS(=O)(=N/C=C(\C#N)/S(=O)(=O)c1ccc(cn1)C(F)(F)F)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L03 compound treatment 63120.0 -7140.0 -0.12 86960.0 -26100.0 -0.42 -0.3774 -0.873 3064122 Maybridge4_002357 CSc1sc(C#N)c(C)c1C(=O)/C=C/N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L04 compound treatment 38800.0 -31500.0 -0.52 48720.0 -64300.0 -1.03 -1.0923 -0.9503 3178665 Maybridge4_002358 CCOC(=O)c1sc(SCCS(=O)(=O)c2ccc(Cl)cc2)c3C(=O)CCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L05 compound treatment 79800.0 9550.0 0.16 123800.0 10700.0 0.17 0.2324 0.9991 1438715 Maybridge4_002359 Cc1c(C=C)c(sc1C(=O)Oc2ccccc2)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L06 compound treatment 79200.0 8950.0 0.15 103280.0 -9780.0 -0.16 -0.0058 -0.0271 3178666 Maybridge4_002360 CC1(C)CC(=O)c2c(SCCOC(=O)c3ccccc3Cl)sc(C#N)c2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L07 compound treatment 7880.0 -62400.0 -1.03 12640.0 -100000.0 -1.6 -1.8598 -0.9772 3064123 Maybridge4_002361 Cc1nn(Cc2nc(cs2)C(C)(C)C)c(C)c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L08 compound treatment 78560.0 8310.0 0.14 108120.0 -4940.0 -0.08 0.0413 0.2609 1009905 Maybridge4_002362 CC(=O)Nc1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L09 compound treatment 58480.0 -11800.0 -0.19 59720.0 -53300.0 -0.85 -0.7386 -0.8469 3178667 Maybridge4_002363 CSc1sc(c2CCCC(=O)c12)c3ccnc(SCC(=O)c4ccc(Cl)cc4)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L10 compound treatment 121560.0 51300.0 0.85 113880.0 819.0 0.01 0.6081 0.7179 3064124 Maybridge4_002364 O=S1(=O)CC=C(C1)Sc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L11 compound treatment 88200.0 17900.0 0.3 106320.0 -6740.0 -0.11 0.1335 0.4236 3178668 Maybridge4_002365 Cc1cc(C)n(CCS(=O)(=O)c2ccc(Cl)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L12 compound treatment 13920.0 -56300.0 -0.93 15120.0 -97900.0 -1.56 -1.7614 -0.9694 3064125 Maybridge4_002366 Clc1ccc(cc1)C(=O)Nc2cc(cs2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L13 compound treatment 48560.0 -21700.0 -0.36 56960.0 -56100.0 -0.89 -0.8855 -0.9193 3178669 Maybridge4_002367 Cc1csc2sc(c(C)c12)c3ccnc(SCC(=O)NCc4ccccc4)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L14 compound treatment 118520.0 48300.0 0.8 118320.0 5260.0 0.08 0.6226 0.7772 1344584 Maybridge4_002368 COC(=O)c1c(C)n2CSCc2c1C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L15 compound treatment 58320.0 -11900.0 -0.2 57120.0 -55900.0 -0.89 -0.7698 -0.843 3178670 Maybridge4_002369 CN(C)/C=C/C(=O)c1ccsc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L16 compound treatment 6000.0 -64300.0 -1.06 8080.0 -105000.0 -1.67 -1.9332 -0.9758 1542795 Maybridge4_002370 CCCCc1ccc(NC(=O)N=S2CCN(CC2)C(=O)c3ccc(Cl)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L17 compound treatment 10760.0 -59500.0 -0.98 19160.0 -93900.0 -1.5 -1.7527 -0.9791 1463535 Maybridge4_002371 CN1c2sc(C)c(C)c2C(=C(C(=O)Nc3ccc(Cl)cc3)S1(=O)=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L18 compound treatment 98280.0 28000.0 0.46 112920.0 -141.0 0.0 0.3255 0.7037 1537505 Maybridge4_002372 Cc1occc1C(=O)C(=C(NCc2cccnc2)NCc3cccnc3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L19 compound treatment 42520.0 -27700.0 -0.46 44280.0 -68800.0 -1.1 -1.0989 -0.925 3064207 Maybridge4_002373 CS(=O)(=O)c1cc2cc(Cl)ccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L20 compound treatment 6480.0 -63800.0 -1.05 10320.0 -103000.0 -1.64 -1.9023 -0.9772 3064208 Maybridge4_002374 FC(F)(F)c1ccc(SC(=O)c2csc(n2)C3COc4ccccc4O3)nc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L21 compound treatment 68800.0 -1460.0 -0.02 103560.0 -9500.0 -0.15 -0.1241 -0.8091 3064209 Maybridge4_002375 CN(C)/C=N/C(=O)c1sc(c2C=CCCc12)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L22 compound treatment 63440.0 -6820.0 -0.11 121360.0 8300.0 0.13 0.014 0.0805 1320320 Maybridge4_002376 O=C(C1Cc2ccccc2C1)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L23 mock treatment 58080.0 -12200.0 -0.2 111000.0 -2060.0 -0.03 -0.1653 -0.8119 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 L24 mock treatment 34960.0 -35300.0 -0.58 83560.0 -29500.0 -0.47 -0.7445 -0.9943 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M01 compound treatment 28720.0 -41500.0 -0.69 49680.0 -63400.0 -1.01 -1.1991 -0.9822 3064210 Maybridge4_002377 OC(=O)c1ccc2ccccc2c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M02 compound treatment 5160.0 -65100.0 -1.07 12680.0 -100000.0 -1.6 -1.8911 -0.9812 3064211 Maybridge4_002378 Clc1ccc(cc1)S(=O)(=O)/C(=C/Nc2cccc(Cl)c2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M03 compound treatment 44320.0 -25900.0 -0.43 89800.0 -23300.0 -0.37 -0.5649 -0.9974 3178671 Maybridge4_002379 COC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M04 compound treatment 47640.0 -22600.0 -0.37 77280.0 -35800.0 -0.57 -0.6672 -0.9789 3178672 Maybridge4_002380 CCOC(=O)/C(=C\Nc1ccc(F)c(Cl)c1)/S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M05 compound treatment 4760.0 -65500.0 -1.08 6640.0 -106000.0 -1.7 -1.9639 -0.9763 3064212 Maybridge4_002381 Clc1ccc(/C=C/C(=O)Nc2cccc(Cl)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M06 compound treatment 70880.0 625.0 0.01 82840.0 -30200.0 -0.48 -0.3333 -0.6918 3064213 Maybridge4_002382 NNC(=O)CS(=O)(=O)c1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M07 compound treatment 21880.0 -48400.0 -0.8 59000.0 -54100.0 -0.86 -1.1739 -0.9993 3178673 Maybridge4_002383 Cc1cc(C)cc(NC(=S)Nc2cc(C)cc(C)c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M08 compound treatment 5760.0 -64500.0 -1.06 10240.0 -103000.0 -1.64 -1.9116 -0.9782 3178674 Maybridge4_002384 Clc1ccc(SCC(=O)Nc2cscc2S(=O)(=O)c3ccc(Cl)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M09 compound treatment 32880.0 -37400.0 -0.62 79240.0 -33800.0 -0.54 -0.8174 -0.9977 1165743 Maybridge4_002385 CCN(CCS(=O)(=O)c1ccc(Cl)cc1)S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M10 compound treatment 56160.0 -14100.0 -0.23 112960.0 -101.0 0.0 -0.1657 -0.712 3178675 Maybridge4_002386 Clc1ccccc1NC(=S)Nc2cscc2S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M11 compound treatment 84280.0 14000.0 0.23 123880.0 10800.0 0.17 0.2856 0.9895 1302916 Maybridge4_002387 CC(C)(C)n1nc(cc1NC(=O)Nc2ccccc2)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M12 compound treatment 153520.0 83300.0 1.37 174360.0 61300.0 0.98 1.6628 0.986 3178676 Maybridge4_002388 COC(=O)c1sc(SC)c(c1C)c2ccn(n2)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M13 compound treatment 125240.0 55000.0 0.91 138160.0 25100.0 0.4 0.9247 0.9322 3064215 Maybridge4_002389 COc1c(Cl)scc1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M14 compound treatment 110360.0 40100.0 0.66 140000.0 26900.0 0.43 0.7717 0.978 3178677 Maybridge4_002390 CC(C)S(=O)(=O)c1csc(C(=O)NN)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M15 compound treatment 6160.0 -64100.0 -1.06 7560.0 -106000.0 -1.68 -1.9372 -0.9751 1619049 Maybridge4_002391 CC(C)(C)c1ccc(cc1)c2[nH]nc(NC(=O)c3ccccc3Cl)c2Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M16 compound treatment 66240.0 -4020.0 -0.07 105880.0 -7180.0 -0.11 -0.1278 -0.9663 3178678 Maybridge4_002392 CSc1sc(C(=O)O)c(I)c1S(=O)(=O)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M17 compound treatment 4640.0 -65600.0 -1.08 7440.0 -106000.0 -1.68 -1.9563 -0.9773 3178679 Maybridge4_002393 CC(C)(C)c1ccc(cc1)C(=O)C(=C2SCCCS2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M18 compound treatment 53400.0 -16900.0 -0.28 105720.0 -7340.0 -0.12 -0.2795 -0.9259 3064216 Maybridge4_002394 CS(=O)(=NC(=O)Nc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M19 compound treatment 71760.0 1510.0 0.02 110920.0 -2140.0 -0.03 -0.0066 -0.1555 3178680 Maybridge4_002395 CSc1nc2cc(C)nn2c(c1C#N)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M20 compound treatment 54600.0 -15700.0 -0.26 74800.0 -38300.0 -0.61 -0.6139 -0.927 1447748 Maybridge4_002396 Clc1ccccc1c2csc(CS(=O)(=O)c3cccs3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M21 compound treatment 32160.0 -38100.0 -0.63 85480.0 -27600.0 -0.44 -0.7555 -0.9847 3178681 Maybridge4_002397 CSc1nc(N)n2nc(cc2n1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M22 compound treatment 23080.0 -47200.0 -0.78 52200.0 -60900.0 -0.97 -1.2366 -0.9941 3178753 Maybridge4_002398 CN(C)/C=C/C(=O)c1sc(SCc2ccc(Cl)cc2)c3C(=O)CC(C)(C)Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M23 mock treatment 53000.0 -17300.0 -0.28 118080.0 5020.0 0.08 -0.1448 -0.4896 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 M24 mock treatment 43800.0 -26500.0 -0.44 75240.0 -37800.0 -0.6 -0.735 -0.9875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N01 compound treatment 16240.0 -54000.0 -0.89 33640.0 -79400.0 -1.27 -1.5256 -0.9853 3064217 Maybridge4_002399 CCOC(=O)c1sc2sc(C(=O)OCC)c(c3ccc(Cl)cc3)c2c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N02 compound treatment 46520.0 -23700.0 -0.39 89360.0 -23700.0 -0.38 -0.5442 -0.9998 3064244 Maybridge4_002400 CCOC(=O)NS(=O)(=O)c1ccc(s1)c2cc(n(C)n2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N03 compound treatment 40720.0 -29500.0 -0.49 56400.0 -56700.0 -0.9 -0.9833 -0.9581 3064245 Maybridge4_002401 CSc1scc2CC(C)(C)CC(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N04 compound treatment 48840.0 -21400.0 -0.35 123200.0 10100.0 0.16 -0.1357 -0.3491 3064246 Maybridge4_002402 CC1(C)CCc2cc(ccc2O1)C3SCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N05 compound treatment 59680.0 -10600.0 -0.17 136720.0 23700.0 0.38 0.1432 0.3446 3064248 Maybridge4_002403 Cc1nn(CC(=S)N)c(C)c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N06 compound treatment 58560.0 -11700.0 -0.19 96040.0 -17000.0 -0.27 -0.3283 -0.9861 1138975 Maybridge4_002404 CC(C)S(=O)(=O)c1cscc1N2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N07 compound treatment 14840.0 -55400.0 -0.91 21840.0 -91200.0 -1.45 -1.6749 -0.9751 3064249 Maybridge4_002405 Fc1cccc(NC(=S)N(CCS(=O)(=O)c2ccc(Cl)cc2)Cc3cccs3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N08 compound treatment 42720.0 -27500.0 -0.45 52840.0 -60200.0 -0.96 -1.0001 -0.9417 3064250 Maybridge4_002406 Clc1ccc(C(=O)C2C(=O)CCC(C2=O)c3ccccc3)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N09 compound treatment 32280.0 -38000.0 -0.63 44560.0 -68500.0 -1.09 -1.2153 -0.9653 3064251 Maybridge4_002407 CSc1sc(c2CC(C)(C)CC(=O)c12)c3ccnc(SCC(=O)C(C)(C)C)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N10 compound treatment 91320.0 21100.0 0.35 113040.0 -21.3 0.0 0.2456 0.7064 1318871 Maybridge4_002408 Cn1ccnc1SCCS(=O)(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N11 compound treatment 61800.0 -8460.0 -0.14 78840.0 -34200.0 -0.55 -0.4844 -0.8603 1250473 Maybridge4_002409 CCOC(=O)c1sc(SCc2ccccc2)c3c1-c4sccc4N(C)S3(=O)=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N12 compound treatment 124320.0 54100.0 0.89 142560.0 29500.0 0.47 0.9635 0.9552 3064253 Maybridge4_002410 FC(F)(F)c1cc(cc(c1)S(=O)(=O)/N=S\2/CCC3(C2)OCCO3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N13 compound treatment 99240.0 29000.0 0.48 132440.0 19400.0 0.31 0.5567 0.9776 1662782 Maybridge4_002411 CSc1sc(c2nc(cs2)C(C)(C)C)c3CCCC(=O)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N14 compound treatment 97040.0 26800.0 0.44 94520.0 -18500.0 -0.3 0.1037 0.195 1607185 Maybridge4_002412 Clc1ccc(cc1)C(=O)N=S2CCN(CC2)C(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N15 compound treatment 43080.0 -27200.0 -0.45 53400.0 -59700.0 -0.95 -0.9896 -0.9412 3178754 Maybridge4_002413 COC(=O)C1=C(CSC1)Nc2ccc(OC(=O)c3cccc(c3)C(F)(F)F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N16 compound treatment 30040.0 -40200.0 -0.66 42640.0 -70400.0 -1.12 -1.2631 -0.9686 1495489 Maybridge4_002414 Clc1ccc(OC(=O)c2cccnc2SCCS(=O)(=O)c3ccccc3)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N17 compound treatment 24840.0 -45400.0 -0.75 40000.0 -73100.0 -1.16 -1.3535 -0.9773 3178755 Maybridge4_002415 CSc1sc(C(=O)NN)c2CCC=Cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N18 compound treatment 46720.0 -23500.0 -0.39 82120.0 -30900.0 -0.49 -0.6234 -0.993 3178756 Maybridge4_002416 CS(=O)(=NS(=O)(=O)c1cccs1)c2ccc(OC(=O)c3ccc(Cl)cc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N19 compound treatment 61720.0 -8540.0 -0.14 87720.0 -25300.0 -0.4 -0.3852 -0.9005 3064254 Maybridge4_002417 CS(=O)(=O)/C(=C/Nc1cnccn1)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N20 compound treatment 77480.0 7230.0 0.12 141720.0 28700.0 0.46 0.4073 0.8628 1627111 Maybridge4_002418 O=C(SCc1cccs1)c2csc(n2)C3COc4ccccc4O3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N21 compound treatment 43720.0 -26500.0 -0.44 76280.0 -36800.0 -0.59 -0.7243 -0.9897 3064255 Maybridge4_002419 FC(F)(F)Oc1ccc(cc1)S(=O)(=O)CCN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N22 compound treatment 25920.0 -44300.0 -0.73 33240.0 -79800.0 -1.27 -1.4171 -0.9655 3178757 Maybridge4_002420 Clc1ccc(cc1)c2cc(NC(=O)C3Cc4ccccc4C3)[nH]n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N23 mock treatment 39520.0 -30700.0 -0.51 91600.0 -21500.0 -0.34 -0.6006 -0.9816 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 N24 mock treatment 47680.0 -22600.0 -0.37 104480.0 -8580.0 -0.14 -0.3602 -0.9074 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O01 compound treatment 15400.0 -54900.0 -0.91 42840.0 -70200.0 -1.12 -1.4317 -0.9945 1259648 Maybridge4_002421 COc1ccc(NC(=O)C(C(=O)Nc2ccc(OC)cc2)C3(CC4CC5CC(C4)C3)C5)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O02 compound treatment 23760.0 -46500.0 -0.77 41040.0 -72000.0 -1.15 -1.3544 -0.9808 3064256 Maybridge4_002422 FC(F)(F)c1cc(N/C=C(\C#N)/S(=O)(=O)c2ccccn2)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O03 compound treatment 8320.0 -61900.0 -1.02 22640.0 -90400.0 -1.44 -1.742 -0.9859 1743228 Maybridge4_002423 Cc1ccc(Nc2cc(O)nn2C)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O04 compound treatment 42520.0 -27700.0 -0.46 104840.0 -8220.0 -0.13 -0.4164 -0.8744 3064257 Maybridge4_002424 CCn1c(S)nc2ccccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O05 compound treatment 2400.0 -67900.0 -1.12 5680.0 -107000.0 -1.71 -2.0022 -0.9789 3178758 Maybridge4_002425 Cc1c(C)c(C)c(CSc2ccccc2N)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O06 compound treatment 12680.0 -57600.0 -0.95 19720.0 -93300.0 -1.49 -1.724 -0.9766 3064258 Maybridge4_002426 CS/C(=C(\C#N)/C(=O)C1CC1)/N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O07 compound treatment 28400.0 -41900.0 -0.69 44280.0 -68800.0 -1.1 -1.2637 -0.9752 1286597 Maybridge4_002427 O=S(=O)(CCN1CCSCC1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O08 compound treatment 21720.0 -48500.0 -0.8 50440.0 -62600.0 -1.0 -1.2723 -0.9941 3064259 Maybridge4_002428 Clc1ccccc1C(=O)Nc2cscc2S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O09 compound treatment 23120.0 -47100.0 -0.78 42000.0 -71100.0 -1.13 -1.3511 -0.9832 3178759 Maybridge4_002429 O=S(=O)(CCSc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O10 compound treatment 38200.0 -32100.0 -0.53 105560.0 -7500.0 -0.12 -0.4587 -0.8456 1558086 Maybridge4_002430 COC(=O)C1=C(CSC1)Nc2ccc(F)cc2F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O11 compound treatment 12000.0 -58300.0 -0.96 14920.0 -98100.0 -1.56 -1.786 -0.9727 3064260 Maybridge4_002431 Cc1cc(C)n2nc(cc2n1)c3ccc(cc3)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O12 compound treatment 69720.0 -535.0 -0.01 96920.0 -16100.0 -0.26 -0.1882 -0.7309 3178760 Maybridge4_002432 CC(C)S(=O)(=O)c1csc(C(=O)OCC(=O)c2ccc(Cl)cc2)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O13 compound treatment 79040.0 8790.0 0.15 112680.0 -381.0 -0.01 0.0982 0.6769 3064262 Maybridge4_002433 Clc1ccc(cc1)S(=O)(=O)/C(=C/N2CCCCC2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O14 compound treatment 50840.0 -19400.0 -0.32 87160.0 -25900.0 -0.41 -0.5185 -0.9922 3178761 Maybridge4_002434 Fc1ccc(NC(=O)c2cccnc2Sc3cccs3)c(F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O15 compound treatment 18000.0 -52300.0 -0.86 13000.0 -100000.0 -1.59 -1.7377 -0.9584 3064263 Maybridge4_002435 Nc1nc(Sc2ccc(Cl)cc2)c(C#N)c(c1C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O16 compound treatment 8440.0 -61800.0 -1.02 14120.0 -98900.0 -1.58 -1.8366 -0.9778 3178762 Maybridge4_002436 CSc1scc(c1C#N)c2cc(Cl)cc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O17 compound treatment 34360.0 -35900.0 -0.59 53520.0 -59500.0 -0.95 -1.09 -0.9743 3064280 Maybridge4_002437 O=C(C(=C1SCCCS1)C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O18 compound treatment 20680.0 -49600.0 -0.82 50160.0 -62900.0 -1.0 -1.2876 -0.9949 3064281 Maybridge4_002438 CN(/N=C(\C#N)/C(=O)C1CC1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O19 compound treatment 69560.0 -695.0 -0.01 92480.0 -20600.0 -0.33 -0.2401 -0.7314 1358615 Maybridge4_002439 COCc1cc(OC(=O)N(C)C)nc2n(C)nc(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O20 compound treatment 27480.0 -42800.0 -0.71 73440.0 -39600.0 -0.63 -0.9458 -0.9984 1379175 Maybridge4_002440 Cn1ccc(n1)c2cccc(NC(=O)Nc3ccccc3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O21 compound treatment 16080.0 -54200.0 -0.89 36600.0 -76500.0 -1.22 -1.4941 -0.9884 3064282 Maybridge4_002441 CSc1c(C#N)c(nn1CNC(=O)Nc2ccccc2C(F)(F)F)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O22 compound treatment 32600.0 -37700.0 -0.62 85080.0 -28000.0 -0.45 -0.7549 -0.9867 3064283 Maybridge4_002442 CCOC(=O)c1sc(SCc2c(Cl)cccc2Cl)c(c1N)S(=O)(=O)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O23 mock treatment 55760.0 -14500.0 -0.24 104280.0 -8780.0 -0.14 -0.2682 -0.9674 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 O24 mock treatment 58080.0 -12200.0 -0.2 89280.0 -23800.0 -0.38 -0.4101 -0.956 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P01 compound treatment 1640.0 -68600.0 -1.13 3480.0 -110000.0 -1.75 -2.0359 -0.978 3064285 Maybridge4_002443 Nc1c(C#N)sc2sc(C#N)c(c3ccco3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P02 compound treatment 36000.0 -34300.0 -0.57 94600.0 -18500.0 -0.29 -0.6079 -0.9537 3064286 Maybridge4_002444 CC(C)(C)c1ncc(c(N)n1)S(=O)(=O)c2ccc(cn2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P03 compound treatment 25320.0 -44900.0 -0.74 55840.0 -57200.0 -0.91 -1.1694 -0.9947 3178763 Maybridge4_002445 CCOC(=O)c1sc(SC)c2C(=O)CC(Cc12)c3ccc(OC)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P04 compound treatment 31400.0 -38900.0 -0.64 54320.0 -58700.0 -0.94 -1.1156 -0.983 3178764 Maybridge4_002446 CCOC(=O)c1sc(Sc2ccc(cn2)C(F)(F)F)c3C(=O)CC(C)(C)Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P05 compound treatment 36000.0 -34300.0 -0.57 71000.0 -42100.0 -0.67 -0.8739 -0.9964 1299033 Maybridge4_002447 CS(=O)(=O)c1sc(C(=O)O)c2CCC=Cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P06 compound treatment 26720.0 -43500.0 -0.72 59840.0 -53200.0 -0.85 -1.108 -0.9966 1436320 Maybridge4_002448 Cc1cc(C)n(n1)c2ncc(c(N)n2)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P07 compound treatment 28960.0 -41300.0 -0.68 39760.0 -73300.0 -1.17 -1.3081 -0.9671 3178765 Maybridge4_002449 CSc1scc2CCc3cn(nc3-c12)C(=O)c4cccc(c4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P08 compound treatment 51640.0 -18600.0 -0.31 79520.0 -33500.0 -0.53 -0.5953 -0.9654 3178766 Maybridge4_002450 CS(=O)(=NC(=O)NC(=O)c1ccc(Cl)cc1)c2ccc(cn2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P09 compound treatment 20760.0 -49500.0 -0.82 42760.0 -70300.0 -1.12 -1.37 -0.988 3064288 Maybridge4_002451 O=S(=O)(N1CCCCC1)c2ccc(s2)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P10 compound treatment 29960.0 -40300.0 -0.67 66280.0 -46800.0 -0.75 -0.9976 -0.9984 3064289 Maybridge4_002452 COC(=O)c1cnc(S)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P11 compound treatment 11000.0 -59300.0 -0.98 15160.0 -97900.0 -1.56 -1.795 -0.9747 3178767 Maybridge4_002453 FC(F)(F)c1cc(NC(=S)NC(=O)Oc2ccccc2)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P12 compound treatment 68320.0 -1940.0 -0.03 83960.0 -29100.0 -0.46 -0.3506 -0.754 3064290 Maybridge4_002454 Cc1ccc(SCC(=O)c2ccc(CC(=O)O)s2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P13 compound treatment 38360.0 -31900.0 -0.53 67960.0 -45100.0 -0.72 -0.8806 -0.9883 3178768 Maybridge4_002455 CS(=O)(=NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P14 compound treatment 24840.0 -45400.0 -0.75 29760.0 -83300.0 -1.33 -1.4689 -0.9634 3064291 Maybridge4_002456 CN(C)/C=C/C(=O)c1ccc2OCCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P15 compound treatment 38800.0 -31500.0 -0.52 40920.0 -72100.0 -1.15 -1.1802 -0.9355 3178769 Maybridge4_002457 Cc1cc2ncc(c(C)n2n1)c3ccnc(SCc4c(Cl)cccc4Cl)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P16 compound treatment 38880.0 -31400.0 -0.52 56880.0 -56200.0 -0.9 -0.9994 -0.9661 3064292 Maybridge4_002458 CS(=O)(=O)CCSc1ncccc1C(=O)NCc2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P17 compound treatment 18520.0 -51700.0 -0.85 21280.0 -91800.0 -1.46 -1.6383 -0.9672 1476633 Maybridge4_002459 CCOC(=O)c1sc(N2CCCCC2)c3C(=O)CC(C)(C)Cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P18 compound treatment 31400.0 -38900.0 -0.64 69560.0 -43500.0 -0.69 -0.9438 -0.9992 3064293 Maybridge4_002460 OC(=O)C1Cc2ccccc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P19 compound treatment 31400.0 -38900.0 -0.64 75480.0 -37600.0 -0.6 -0.8771 -0.9994 3178770 Maybridge4_002461 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/Nc2cnccn2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P20 compound treatment 15480.0 -54800.0 -0.9 30840.0 -82200.0 -1.31 -1.566 -0.9836 1356891 Maybridge4_002462 CCOC(=O)CC1Sc2ccccc2N=C1SCC(=O)Nc3ccc(Cl)cc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P21 compound treatment 51560.0 -18700.0 -0.31 127960.0 14900.0 0.24 -0.0503 -0.1292 3064294 Maybridge4_002463 Clc1ccc(Sc2ccc(s2)c3ccccn3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P22 compound treatment 38040.0 -32200.0 -0.53 70520.0 -42500.0 -0.68 -0.8555 -0.9928 1623679 Maybridge4_002464 Cc1ccc(NC(=O)c2ccc3OCCc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P23 mock treatment 45600.0 -24700.0 -0.41 106760.0 -6300.0 -0.1 -0.3588 -0.8559 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2055 P24 mock treatment 66280.0 -3980.0 -0.07 112320.0 -741.0 -0.01 -0.0548 -0.8212 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A01 compound treatment 26720.0 -37100.0 -0.61 16920.0 -40400.0 -0.64 -0.8876 -0.9997 3179279 Maybridge4_002817 CCOC(=S)Nc1ccc(I)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A02 compound treatment 8080.0 -55700.0 -0.92 15800.0 -41500.0 -0.66 -1.1178 -0.9869 3179280 Maybridge4_002818 Cn1c(/C=C/C=C/N2CCCC2)nc3ccccc3c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A03 compound treatment 63600.0 -203.0 0.0 95360.0 38100.0 0.61 0.4269 0.7032 3063974 Maybridge4_002819 CCCn1c(n[nH]c1=O)c2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A04 compound treatment 11560.0 -52200.0 -0.86 11600.0 -45700.0 -0.73 -1.1245 -0.9964 3179380 Maybridge4_002820 CCOC(=O)c1cnc(S/C=C/C(=O)c2ccc(Cl)cc2)nc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A05 compound treatment 56760.0 -7040.0 -0.12 143720.0 86400.0 1.38 0.8921 0.6452 1487054 Maybridge4_002821 Cc1ccccc1S(=O)c2ccccc2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A06 compound treatment 6000.0 -57800.0 -0.95 39800.0 -17500.0 -0.28 -0.8716 -0.8769 3064003 Maybridge4_002822 N(/C=N/c1ccc2ccccc2c1)c3ccc4ccccc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A07 compound treatment 37280.0 -26500.0 -0.44 224720.0 167000.0 2.67 1.5776 0.5833 1198685 Maybridge4_002823 CC(C)CC(NC(=O)Nc1cccc2ccccc12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A08 compound treatment 31120.0 -32700.0 -0.54 157840.0 101000.0 1.6 0.7519 0.4446 3064005 Maybridge4_002824 FC(F)(F)c1ncncc1c2nnnn2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A09 compound treatment 13920.0 -49900.0 -0.82 44200.0 -13100.0 -0.21 -0.7296 -0.8589 3064006 Maybridge4_002825 CN(C)/C=C(\C(=S)c1ccccc1)/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A10 compound treatment 2440.0 -61400.0 -1.01 6680.0 -50600.0 -0.81 -1.2864 -0.9936 3064007 Maybridge4_002826 Clc1ccc(O/C=C/C(=O)c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A11 compound treatment 43960.0 -19800.0 -0.33 115680.0 58400.0 0.93 0.4267 0.4323 1652788 Maybridge4_002827 CN1C(=O)C(Cc2ccccc2)(Cc3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A12 compound treatment 57600.0 -6200.0 -0.1 127080.0 69800.0 1.11 0.7144 0.6393 3064008 Maybridge4_002828 O=c1[nH]c2ccccc2c(=O)n1CCNCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A13 compound treatment 76280.0 12500.0 0.21 131560.0 74300.0 1.18 0.9829 0.8178 3064009 Maybridge4_002829 C/C(=N\O)/C(=O)Nc1cccc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A14 compound treatment 3840.0 -60000.0 -0.99 8520.0 -48800.0 -0.78 -1.2493 -0.9928 3179381 Maybridge4_002830 Clc1ccc(/C=C(\C#N)/c2c[nH]c3ccccc23)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A15 compound treatment 42960.0 -20800.0 -0.34 166480.0 109000.0 1.74 0.9875 0.5566 3179382 Maybridge4_002831 O=C(/C=C\1/Nc2[nH]c(=S)[nH]c(=O)c2NC1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A16 compound treatment 15840.0 -48000.0 -0.79 20800.0 -36500.0 -0.58 -0.9709 -0.9885 3064010 Maybridge4_002832 FC(F)(F)c1ccc(/C=C(\C#N)/c2cn(C(=O)C3CCC3)c4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A17 compound treatment 50360.0 -13400.0 -0.22 117840.0 60600.0 0.97 0.5257 0.5307 1477955 Maybridge4_002833 Cc1c(O)c(C(=O)c2nn[nH]n2)c(=O)n(c3ccccc3)c1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A18 compound treatment 35480.0 -28300.0 -0.47 188880.0 132000.0 2.1 1.1527 0.5363 1152993 Maybridge4_002834 COc1ccc(CC(=O)NN2C(=O)CSCC2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A19 compound treatment 1960.0 -61800.0 -1.02 6400.0 -50900.0 -0.81 -1.2952 -0.9935 3179383 Maybridge4_002835 O=C(C/C(=C\1/CCc2ccccc2C1=O)/c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A20 compound treatment 2480.0 -61300.0 -1.01 19960.0 -37300.0 -0.59 -1.1363 -0.9679 3179384 Maybridge4_002836 CC1CC(CC(C)(C)C1)NC(=S)NCc2csc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A21 compound treatment 1800.0 -62000.0 -1.02 4280.0 -53000.0 -0.84 -1.3209 -0.9954 1438428 Maybridge4_002837 CC12CCC3C(CC=C4CC(O)CCC34CO)C2CCC1OC(=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A22 compound treatment 3840.0 -60000.0 -0.99 12600.0 -44700.0 -0.71 -1.2034 -0.9869 3179385 Maybridge4_002838 CC(=O)Nc1ccc(cc1)C2=N/C(=C/c3cn(C(=O)C)c4ccccc34)/C(=O)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A23 mock treatment 38680.0 -25100.0 -0.41 64560.0 7290.0 0.12 -0.2111 -0.4902 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 A24 mock treatment 57120.0 -6680.0 -0.11 45280.0 -12000.0 -0.19 -0.2131 -0.9659 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B01 compound treatment 49440.0 -14400.0 -0.24 61200.0 3930.0 0.06 -0.1234 -0.5031 1595249 Maybridge4_002839 COc1ccc(cc1)C2C(C(=O)O)c3ccccc3C(=O)N2Cc4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B02 compound treatment 57360.0 -6440.0 -0.11 117400.0 60100.0 0.96 0.6025 0.6248 3064011 Maybridge4_002840 FC(F)(F)c1nnc(Nc2cccnc2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B03 compound treatment 41880.0 -21900.0 -0.36 131280.0 74000.0 1.18 0.5782 0.4686 1011958 Maybridge4_002841 CC(=O)Nc1ccc(Cc2ccc(NC(=O)C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B04 compound treatment 3880.0 -59900.0 -0.99 10200.0 -47100.0 -0.75 -1.2299 -0.9907 3179386 Maybridge4_002842 O=C1N(C2CCCCC2)/C(=N/C3CCCCC3)/SC41CC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B05 compound treatment 74760.0 11000.0 0.18 142720.0 85400.0 1.36 1.0909 0.794 3064012 Maybridge4_002843 CS/C(=N\C#N)/N=c\1/nc(SC)n(C)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B06 compound treatment 3400.0 -60400.0 -1.0 9000.0 -48300.0 -0.77 -1.2491 -0.9918 3179387 Maybridge4_002844 Cc1cc(S)nc(n1)c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B07 compound treatment 33480.0 -30300.0 -0.5 141480.0 84200.0 1.34 0.5951 0.4155 3064013 Maybridge4_002845 Cc1csc(Nc2c(C)cccc2C)[n+]1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B08 compound treatment 23120.0 -40700.0 -0.67 126520.0 69200.0 1.1 0.3056 0.2365 3179388 Maybridge4_002846 Cc1nc(nc(NCCNc2cc(ccn2)C(F)(F)F)c1Cl)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B09 compound treatment 32520.0 -31300.0 -0.52 107800.0 50500.0 0.81 0.2043 0.2136 3064014 Maybridge4_002847 Clc1ccc(/C=C(\C#N)/c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B10 compound treatment 19400.0 -44400.0 -0.73 45360.0 -11900.0 -0.19 -0.6525 -0.8618 1673007 Maybridge4_002848 COc1ccc(CCNC(=O)C(Sc2ccc(Cl)cc2)c3ccccc3)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B11 compound treatment 39240.0 -24600.0 -0.41 68440.0 11200.0 0.18 -0.1608 -0.3632 1278976 Maybridge4_002849 CSc1nc2ccccc2c(=O)n1CCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B12 compound treatment 8360.0 -55400.0 -0.92 52960.0 -4310.0 -0.07 -0.6957 -0.7581 3179389 Maybridge4_002850 CCOC(=O)/C(=N\O)/C1=CSC2=NNC(C)(C)N12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B13 compound treatment 111880.0 48100.0 0.79 158320.0 101000.0 1.61 1.7 0.9468 1697626 Maybridge4_002851 Oc1ccccc1C(=O)Nc2ccc(NC(=O)c3ccc(Cl)cc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B14 compound treatment 54200.0 -9600.0 -0.16 118760.0 61500.0 0.98 0.5809 0.5851 1029066 Maybridge4_002852 OC(Cc1cccnc1)(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B15 compound treatment 35720.0 -28100.0 -0.46 103400.0 46100.0 0.74 0.1921 0.221 3179390 Maybridge4_002853 Cn/1c(cs\c1=N/C(=S)NCCc2ccccc2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B16 compound treatment 38000.0 -25800.0 -0.43 144760.0 87500.0 1.39 0.6848 0.4697 1414388 Maybridge4_002854 Cc1ccc2onc(OC(=O)NC(C)(C)C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B17 compound treatment 35880.0 -27900.0 -0.46 135000.0 77700.0 1.24 0.5501 0.4162 3064015 Maybridge4_002855 CS/C(=N\c1ccc(Cl)cc1)/N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B18 compound treatment 4480.0 -59300.0 -0.98 20840.0 -36400.0 -0.58 -1.103 -0.9689 1450668 Maybridge4_002856 CNC(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B19 compound treatment 38280.0 -25500.0 -0.42 87040.0 29800.0 0.47 0.0376 0.0592 1567287 Maybridge4_002857 COc1cc(CSc2nnnn2c3ccc(C)cc3C)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B20 compound treatment 43840.0 -20000.0 -0.33 147680.0 90400.0 1.44 0.7859 0.5317 1505699 Maybridge4_002858 COC(=O)c1c(NC(=O)N(C)C)onc1c2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B21 compound treatment 36680.0 -27100.0 -0.45 72640.0 15400.0 0.24 -0.1434 -0.2809 1506761 Maybridge4_002859 NCCSC(=S)NC1CCCCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B22 compound treatment 47240.0 -16600.0 -0.27 114360.0 57100.0 0.91 0.4501 0.4737 3064016 Maybridge4_002860 CN(C)/C=N/C1NC(=O)N(C)C(=N1)C2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B23 mock treatment 58600.0 -5200.0 -0.09 102320.0 45000.0 0.72 0.447 0.6181 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 B24 mock treatment 57920.0 -5880.0 -0.1 73880.0 16600.0 0.26 0.1185 0.4203 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C01 compound treatment 32320.0 -31500.0 -0.52 92680.0 35400.0 0.56 0.0316 0.0412 1030385 Maybridge4_002861 S=C(NC1CCCCC1)C(=S)NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C02 compound treatment 34080.0 -29700.0 -0.49 77280.0 20000.0 0.32 -0.1214 -0.2075 3064017 Maybridge4_002862 Clc1ccc(cc1)C(=O)c2[n+]([N-]C#N)ccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C03 compound treatment 48720.0 -15100.0 -0.25 102280.0 45000.0 0.72 0.3312 0.4362 3179391 Maybridge4_002863 CCCn1c(n[nH]c1=O)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C04 compound treatment 3560.0 -60200.0 -0.99 6080.0 -51200.0 -0.82 -1.2801 -0.9952 3064018 Maybridge4_002864 O=C(/C=C/Sc1ccccn1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C05 compound treatment 55200.0 -8600.0 -0.14 123840.0 66600.0 1.06 0.6498 0.6071 3179392 Maybridge4_002865 CCNS(=O)(=O)c1ccc(Cl)cc1I 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C06 compound treatment 64920.0 1120.0 0.02 122120.0 64800.0 1.03 0.7439 0.7196 3064054 Maybridge4_002866 CC1C(O/C(=N\S(=O)(=O)c2ccc(Cl)cc2)/N1C)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C07 compound treatment 48280.0 -15500.0 -0.26 159400.0 102000.0 1.63 0.9698 0.5886 1049317 Maybridge4_002867 OC(=O)CCNC(=O)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C08 compound treatment 25960.0 -37800.0 -0.62 98200.0 40900.0 0.65 0.0196 0.0217 3064055 Maybridge4_002868 Oc1c([I+]c2ccccc2)c(=O)[nH]c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C09 compound treatment 39680.0 -24100.0 -0.4 143880.0 86600.0 1.38 0.6945 0.4834 3064056 Maybridge4_002869 N#CC(Cc1ccccc1)(Cc2ccccc2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C10 compound treatment 29200.0 -34600.0 -0.57 78160.0 20900.0 0.33 -0.1685 -0.2548 1357025 Maybridge4_002870 CC1(C)c2cc(Cl)ccc2-n3c1cc(O)c(c4ccccc4)c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C11 compound treatment 38440.0 -25400.0 -0.42 158240.0 101000.0 1.61 0.8419 0.5063 1019915 Maybridge4_002871 Cc1ccc(cc1)C(O)c2nccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C12 compound treatment 6360.0 -57400.0 -0.95 11680.0 -45600.0 -0.73 -1.1843 -0.9914 3064058 Maybridge4_002872 O/N=C/C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C13 compound treatment 130360.0 66600.0 1.1 159760.0 102000.0 1.63 1.932 0.9814 3064059 Maybridge4_002873 CC(C)/C(=N/O)/c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C14 compound treatment 60240.0 -3560.0 -0.06 155920.0 98600.0 1.57 1.0702 0.6802 1733383 Maybridge4_002874 CCCCC1(CO)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C15 compound treatment 5040.0 -58800.0 -0.97 17880.0 -39400.0 -0.63 -1.1298 -0.9778 1134906 Maybridge4_002875 NC(=O)NC1C(Oc2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C16 compound treatment 3960.0 -59800.0 -0.99 10600.0 -46700.0 -0.74 -1.2245 -0.9902 1708436 Maybridge4_002876 CSc1[nH]nc(NS(=O)(=O)c2ccc(Cl)cc2)c1c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C17 compound treatment 26640.0 -37200.0 -0.61 57320.0 48.8 0.0 -0.4332 -0.7062 1325632 Maybridge4_002877 CCCCc1c(O)c2cccc3c4ccccc4n(c1=O)c32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C18 compound treatment 45360.0 -18400.0 -0.3 144760.0 87500.0 1.39 0.7707 0.54 3179393 Maybridge4_002878 O=C1NCCN1CC/N=C/c2ccc(C#N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C19 compound treatment 45960.0 -17800.0 -0.29 142320.0 85000.0 1.36 0.7503 0.5408 3064061 Maybridge4_002879 c1c2ccccc2c3ccc(oc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C20 compound treatment 13200.0 -50600.0 -0.84 36040.0 -21200.0 -0.34 -0.8299 -0.9209 1357662 Maybridge4_002880 CC(C)c1ccc(NN2C(=O)CC(C2=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C21 compound treatment 6800.0 -57000.0 -0.94 7600.0 -49700.0 -0.79 -1.2252 -0.9963 1704922 Maybridge4_002881 COc1cc(C)c2C3CCC4(C)C(O)CCC4C3CCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C22 compound treatment 53800.0 -10000.0 -0.17 116520.0 59200.0 0.94 0.551 0.5748 1187010 Maybridge4_002882 Fc1ccc(C(=O)OCCn2ncc3ccccc3c2=O)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C23 mock treatment 49520.0 -14300.0 -0.24 82320.0 25000.0 0.4 0.1156 0.2493 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 C24 mock treatment 62320.0 -1480.0 -0.02 75360.0 18100.0 0.29 0.1866 0.6448 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D01 compound treatment 53120.0 -10700.0 -0.18 79120.0 21800.0 0.35 0.1216 0.3114 1248994 Maybridge4_002883 CC(C)(C)OC(=O)NC1CCN(CC1)C(=O)CSCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D02 compound treatment 35280.0 -28500.0 -0.47 78360.0 21100.0 0.34 -0.0953 -0.1647 3064062 Maybridge4_002884 Cc1ccc(/N=C/2\SC3(CC3)C(=O)N2c4ccc(C)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D03 compound treatment 20800.0 -43000.0 -0.71 34280.0 -23000.0 -0.37 -0.7611 -0.9527 3179394 Maybridge4_002885 Clc1cccc(c1)/C(=C/C=C/c2ccccc2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D04 compound treatment 30840.0 -33000.0 -0.54 39520.0 -17800.0 -0.28 -0.5848 -0.9536 3064063 Maybridge4_002886 Clc1cccc(/N=C/2\SC3(CC3)C(=O)N2c4cccc(Cl)c4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D05 compound treatment 112840.0 49000.0 0.81 139320.0 82000.0 1.31 1.4971 0.9734 3179395 Maybridge4_002887 CCc1nn(C)c2c(=O)c(=O)c2n(C)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D06 compound treatment 81960.0 18200.0 0.3 147360.0 90100.0 1.44 1.2273 0.8367 3064064 Maybridge4_002888 CC1=NNC(=O)C1Oc2ccc(Cl)cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D07 compound treatment 52360.0 -11400.0 -0.19 147600.0 90300.0 1.44 0.8845 0.6091 3179396 Maybridge4_002889 CSC(=N)Nc1c(Cl)cccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D08 compound treatment 18320.0 -45500.0 -0.75 59040.0 1770.0 0.03 -0.511 -0.6801 3179397 Maybridge4_002890 Cc1nc(nc(NCCNc2ccc(cn2)C(F)(F)F)c1Cl)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D09 compound treatment 76240.0 12400.0 0.21 131200.0 73900.0 1.18 0.9784 0.818 3064065 Maybridge4_002891 Cc1cc(O)nc(SCC(=O)c2ccc(F)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D10 compound treatment 74440.0 10600.0 0.18 148120.0 90800.0 1.45 1.1481 0.7871 1513804 Maybridge4_002892 CCOC(=O)c1c(C)c(ccc1N(C)C)C2NC(=O)NC=C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D11 compound treatment 16200.0 -47600.0 -0.79 41000.0 -16300.0 -0.26 -0.739 -0.8931 3064066 Maybridge4_002893 O=C(CSc1nc2ccccc2c(=O)n1Cc3ccco3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D12 compound treatment 107280.0 43500.0 0.72 147960.0 90700.0 1.45 1.5296 0.9478 3179501 Maybridge4_002894 CC(C)(C)c1ccc(cc1)/C(=N/O)/N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D13 compound treatment 86400.0 22600.0 0.37 100240.0 43000.0 0.68 0.748 0.9592 1669360 Maybridge4_002895 Clc1ccc(cc1)C(=O)Nc2cc(Cl)ccc2C(=O)OCC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D14 compound treatment 28400.0 -35400.0 -0.58 68680.0 11400.0 0.18 -0.2847 -0.4651 3064067 Maybridge4_002896 CC(C)Nc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D15 compound treatment 74960.0 11200.0 0.18 173360.0 116000.0 1.85 1.4386 0.7737 3064068 Maybridge4_002897 S=C(NC1CCCCC1)N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D16 compound treatment 55080.0 -8720.0 -0.14 154520.0 97200.0 1.55 0.9942 0.6387 1715674 Maybridge4_002898 CN(C)c1nc(cc2C(=O)NC(=O)c21)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D17 compound treatment 42000.0 -21800.0 -0.36 77560.0 20300.0 0.32 -0.0258 -0.0534 3064069 Maybridge4_002899 CN(C)/C(=N/c1cc(C)c(C)cc1C)/NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D18 compound treatment 46160.0 -17600.0 -0.29 106640.0 49400.0 0.79 0.3505 0.4177 3179502 Maybridge4_002900 COc1ccc(/N=c/2\scc(C)n2C(=O)c3ccccc3Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D19 compound treatment 56240.0 -7560.0 -0.12 163200.0 106000.0 1.69 1.1056 0.653 1153907 Maybridge4_002901 COc1ccc(OCC(O)CNC(C)(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D20 compound treatment 72800.0 9000.0 0.15 142120.0 84800.0 1.35 1.0613 0.7801 3064070 Maybridge4_002902 Clc1cccc(Cl)c1c2cc(on2)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D21 compound treatment 42520.0 -21300.0 -0.35 101960.0 44700.0 0.71 0.2552 0.3214 1636805 Maybridge4_002903 Brc1ccc(OCC2CN(C(=O)O2)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D22 compound treatment 49600.0 -14200.0 -0.23 101720.0 44400.0 0.71 0.3352 0.4492 3064071 Maybridge4_002904 CC(C)c1nc(/N=C/N(C)C)nc(=O)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D23 mock treatment 54880.0 -8920.0 -0.15 74760.0 17500.0 0.28 0.093 0.2948 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 D24 mock treatment 30640.0 -33200.0 -0.55 56880.0 -391.0 -0.01 -0.3915 -0.7151 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E01 compound treatment 33800.0 -30000.0 -0.5 88240.0 31000.0 0.49 -0.0012 -0.0017 3179503 Maybridge4_002905 O=C(CSc1ccccn1)Nc2ccccc2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E02 compound treatment 6800.0 -57000.0 -0.94 13560.0 -43700.0 -0.7 -1.158 -0.9891 3179504 Maybridge4_002906 N#CC1(N=C2C=CC=CN2N=C1c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E03 compound treatment 22240.0 -41600.0 -0.69 25520.0 -31800.0 -0.51 -0.843 -0.9888 3064072 Maybridge4_002907 O=C1OC2(CCCCC2)OC(=O)C1=Cc3ccoc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E04 compound treatment 8480.0 -55300.0 -0.91 9600.0 -47700.0 -0.76 -1.183 -0.9958 3179505 Maybridge4_002908 FC(F)(F)c1cc(nc(S/C=C/C(=O)c2ccccc2)c1C#N)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E05 compound treatment 97160.0 33400.0 0.55 124920.0 67600.0 1.08 1.1518 0.9513 3064073 Maybridge4_002909 CNS(=O)(=O)c1ccc(Br)cc1I 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E06 compound treatment 111280.0 47500.0 0.78 139200.0 81900.0 1.31 1.4775 0.9702 3179506 Maybridge4_002910 CC(=O)O[C@@H]1O[C@@H]2CO[C@H](O[C@H]2[C@H](OC(=O)C)[C@H]1OC(=O)C)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E07 compound treatment 41240.0 -22600.0 -0.37 67360.0 10100.0 0.16 -0.1497 -0.3689 1547193 Maybridge4_002911 CCNS(=O)(=O)c1cccc2c(N)cccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E08 compound treatment 74880.0 11100.0 0.18 146400.0 89100.0 1.42 1.1338 0.7916 1448662 Maybridge4_002912 CCc1c(O)c(Cc2ccccc2)c(=O)n(c3nccs3)c1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E09 compound treatment 51400.0 -12400.0 -0.2 105120.0 47800.0 0.76 0.3945 0.4996 3179507 Maybridge4_002913 CCOC(=O)C(C#N)C1(C(=NN(C1=O)c2ccccc2)C)c3c(C)nn(c3O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E10 compound treatment 7240.0 -56600.0 -0.93 12920.0 -44400.0 -0.71 -1.1601 -0.9906 3064074 Maybridge4_002914 Fc1ccc(cc1)C(=O)/C=C/S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E11 compound treatment 18880.0 -44900.0 -0.74 108960.0 51700.0 0.82 0.0582 0.0525 1495930 Maybridge4_002915 CC(C)C(OC(=O)c1ccccc1)c2nccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E12 compound treatment 111920.0 48100.0 0.79 154240.0 97000.0 1.55 1.6545 0.9521 1260619 Maybridge4_002916 COC(=O)c1sc2c(C)cc(Cl)c(C)c2c1C(=O)Oc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E13 compound treatment 121960.0 58200.0 0.96 154720.0 97400.0 1.55 1.7771 0.9733 1268159 Maybridge4_002917 CCn1c(=O)cc(O)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E14 compound treatment 108920.0 45100.0 0.74 150120.0 92800.0 1.48 1.5731 0.9495 1134720 Maybridge4_002918 CCCCC1(COC(=O)c2ccc(OC)cc2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E15 compound treatment 25560.0 -38200.0 -0.63 84840.0 27600.0 0.44 -0.1357 -0.1764 3063981 Maybridge4_002919 Clc1cc(Cl)c2c(=O)cc(oc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E16 compound treatment 46160.0 -17600.0 -0.29 71800.0 14500.0 0.23 -0.0422 -0.1134 3063982 Maybridge4_002920 O=C(CSc1nc(SCC(=O)c2ccccc2)c3ccccc3n1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E17 compound treatment 46880.0 -16900.0 -0.28 73560.0 16300.0 0.26 -0.0139 -0.0366 1617223 Maybridge4_002921 Oc1c(Cc2ccccc2)c(=O)n3c4ccccc4c5cccc1c53 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E18 compound treatment 20240.0 -43600.0 -0.72 70560.0 13300.0 0.21 -0.3587 -0.4785 3063983 Maybridge4_002922 Clc1ccc(CCN2C(=O)CSC2=S)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E19 compound treatment 27760.0 -36000.0 -0.59 56000.0 -1270.0 -0.02 -0.435 -0.7308 3179508 Maybridge4_002923 CCc1c(C)oc2cc3ccccc3c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E20 compound treatment 7520.0 -56300.0 -0.93 14320.0 -43000.0 -0.68 -1.141 -0.9887 1212790 Maybridge4_002924 O=C(CSc1nc2ccccc2c(=O)[nH]1)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E21 compound treatment 15520.0 -48300.0 -0.8 21080.0 -36200.0 -0.58 -0.9715 -0.9874 3179509 Maybridge4_002925 CC(OC(=O)C)C1CCC2C3CC[C@H]4CC(=O)CCC4(C)C3CCC12C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E22 compound treatment 57320.0 -6480.0 -0.11 101920.0 44600.0 0.71 0.4275 0.5941 1296117 Maybridge4_002926 O=C(OCCn1ncc2ccccc2c1=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E23 mock treatment 66800.0 3000.0 0.05 79520.0 22200.0 0.35 0.2857 0.798 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 E24 mock treatment 35200.0 -28600.0 -0.47 58520.0 1250.0 0.02 -0.3198 -0.6767 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F01 compound treatment 28160.0 -35600.0 -0.59 90240.0 33000.0 0.53 -0.0445 -0.0564 1646144 Maybridge4_002927 CCCCC1(CN2CCN(Cc3ccccc3)CC2)C(=O)N(N(C1=O)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F02 compound treatment 36480.0 -27300.0 -0.45 87680.0 30400.0 0.48 0.0238 0.0359 1353488 Maybridge4_002928 OC(COc1ccc(F)cc1)CS(=O)(=O)Cc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F03 compound treatment 18960.0 -44800.0 -0.74 34320.0 -23000.0 -0.37 -0.7821 -0.9472 3064021 Maybridge4_002929 CCc1ccc(cc1)/C(=C/C=C/c2ccccc2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F04 compound treatment 45040.0 -18800.0 -0.31 57160.0 -111.0 0.0 -0.2203 -0.7111 1107774 Maybridge4_002930 Fc1ccc(NC(=S)C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F05 compound treatment 52040.0 -11800.0 -0.19 72600.0 15300.0 0.24 0.0355 0.1136 1733993 Maybridge4_002931 CCc1cccc(CC)c1NC(=S)Nc2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F06 compound treatment 123680.0 59900.0 0.99 125480.0 68200.0 1.09 1.4676 0.9989 3179510 Maybridge4_002932 FC(F)(F)c1ccc(cc1)C(=O)Nc2ccc(cc2)C3=NCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F07 compound treatment 9480.0 -54300.0 -0.9 13080.0 -44200.0 -0.7 -1.1321 -0.9929 3064024 Maybridge4_002933 Cc1cccc(Cl)c1NC(=S)NC(Cc2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F08 compound treatment 133080.0 69300.0 1.14 145480.0 88200.0 1.41 1.8028 0.9947 1491434 Maybridge4_002934 C1CN(CCO1)c2nc(ns2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F09 compound treatment 106720.0 42900.0 0.71 155160.0 97900.0 1.56 1.6042 0.9362 1641045 Maybridge4_002935 CC(C)(CO)NC(=S)NCC1CCCO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F10 compound treatment 124440.0 60600.0 1.0 157320.0 100000.0 1.59 1.8354 0.9748 3179511 Maybridge4_002936 O/N=C/c1c(F)cccc1F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F11 compound treatment 28200.0 -35600.0 -0.59 56760.0 -511.0 -0.01 -0.4213 -0.7168 3179512 Maybridge4_002937 Sc1nc2ccccc2c(=O)n1c3ccc(Cl)c(Cl)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F12 compound treatment 133600.0 69800.0 1.15 161120.0 104000.0 1.66 1.9851 0.9843 3064025 Maybridge4_002938 Cc1cc(nn1c2ccccc2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F13 compound treatment 121880.0 58100.0 0.96 135600.0 78300.0 1.25 1.5607 0.9915 3064027 Maybridge4_002939 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F14 compound treatment 69840.0 6040.0 0.1 83280.0 26000.0 0.41 0.3636 0.8528 3179513 Maybridge4_002940 CC(C)Sc1nc(cc(c1C#N)C(F)(F)F)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F15 compound treatment 8640.0 -55200.0 -0.91 12640.0 -44600.0 -0.71 -1.1469 -0.9925 3179514 Maybridge4_002941 CCOC(=O)c1ccc(NC(=N)SCc2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F16 compound treatment 6000.0 -57800.0 -0.95 9480.0 -47800.0 -0.76 -1.2133 -0.9938 3064028 Maybridge4_002942 Cc1onc(c1N)c2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F17 compound treatment 57360.0 -6440.0 -0.11 115760.0 58500.0 0.93 0.584 0.6224 3064029 Maybridge4_002943 Cc1cc(C)c(NC(=N)NN)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F18 compound treatment 97880.0 34100.0 0.56 166720.0 109000.0 1.74 1.6313 0.89 3179515 Maybridge4_002944 COC(=O)c1c(noc1C(=O)NN)c2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F19 compound treatment 34840.0 -29000.0 -0.48 43600.0 -13700.0 -0.22 -0.4921 -0.9367 1249379 Maybridge4_002945 COc1c(Cl)cccc1c2cn3ccc(C)cc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F20 compound treatment 25840.0 -38000.0 -0.63 29600.0 -27700.0 -0.44 -0.755 -0.9852 1721352 Maybridge4_002946 Oc1nsc(Nc2ccccc2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F21 compound treatment 71240.0 7440.0 0.12 138560.0 81300.0 1.3 1.003 0.7707 1132779 Maybridge4_002947 COc1ccc(COCC(O)CS(=O)(=O)c2ccc(OC)c(OC)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F22 compound treatment 66280.0 2480.0 0.04 97080.0 39800.0 0.63 0.4776 0.7511 3064075 Maybridge4_002948 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F23 mock treatment 71720.0 7920.0 0.13 64800.0 7530.0 0.12 0.1773 0.9991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 F24 mock treatment 33960.0 -29800.0 -0.49 64120.0 6850.0 0.11 -0.2711 -0.5374 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G01 compound treatment 44640.0 -19200.0 -0.32 78320.0 21000.0 0.34 0.0136 0.0294 1511541 Maybridge4_002949 Fc1ccc(NC(=O)C(=S)NC2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G02 compound treatment 42800.0 -21000.0 -0.35 66280.0 9010.0 0.14 -0.1436 -0.3827 1391130 Maybridge4_002950 Clc1ccc(Nc2nnc3c4ccccc4c5ccccc5c3n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G03 compound treatment 66080.0 2280.0 0.04 86560.0 29300.0 0.47 0.3567 0.7616 3179516 Maybridge4_002951 CC1C(=NN(C1=O)c2ccccc2)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G04 compound treatment 6160.0 -57600.0 -0.95 7280.0 -50000.0 -0.8 -1.2362 -0.9961 3179517 Maybridge4_002952 Cc1ccc2[nH]c(S/C=C/C(=O)c3ccccc3)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G05 compound treatment 92240.0 28400.0 0.47 94360.0 37100.0 0.59 0.7499 0.9935 1247714 Maybridge4_002953 CNS(=O)(=O)c1c(I)ccc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G06 compound treatment 127400.0 63600.0 1.05 153120.0 95800.0 1.53 1.8226 0.9832 3179612 Maybridge4_002954 CC(=O)N1[C@H](SC(C)(C)[C@@H]1C(=O)O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G07 compound treatment 93080.0 29300.0 0.48 125840.0 68600.0 1.09 1.1145 0.9327 1286617 Maybridge4_002955 COc1cc2OC(C)(C)CC(=O)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G08 compound treatment 106680.0 42900.0 0.71 151400.0 94100.0 1.5 1.5613 0.9412 3179613 Maybridge4_002956 CC(=O)OC(C#N)[C@H]1O[C@@H]2OC(C)(C)O[C@@H]2[C@H]1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G09 compound treatment 124400.0 60600.0 1.0 143040.0 85800.0 1.37 1.674 0.9882 3064077 Maybridge4_002957 OC(=O)CCc1n[nH]c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G10 compound treatment 98160.0 34400.0 0.57 128360.0 71100.0 1.13 1.2022 0.9488 3064078 Maybridge4_002958 Cc1c(cnn1c2ccccc2)c3nnnn3c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G11 compound treatment 126880.0 63100.0 1.04 133960.0 76700.0 1.22 1.6006 0.9968 3179614 Maybridge4_002959 O=S(CC#N)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G12 compound treatment 119480.0 55700.0 0.92 86720.0 29400.0 0.47 0.9818 0.9513 3179615 Maybridge4_002960 FC(F)(F)c1cccc(OC(=O)c2cc3ccc4ccccc4c3s2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G13 compound treatment 11200.0 -52600.0 -0.87 12320.0 -45000.0 -0.72 -1.1206 -0.9954 3064081 Maybridge4_002961 CC(C)CC(C(O)c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G14 compound treatment 102360.0 38600.0 0.64 97480.0 40200.0 0.64 0.9032 1.0 1388837 Maybridge4_002962 CCCCC1(COC(=O)Nc2cccc(Cl)c2)C(=O)N(N(C1=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G15 compound treatment 105880.0 42100.0 0.69 127320.0 70000.0 1.12 1.2806 0.9739 3064082 Maybridge4_002963 NC1=NC(C(N1)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G16 compound treatment 113240.0 49400.0 0.82 122400.0 65100.0 1.04 1.3111 0.9929 3179616 Maybridge4_002964 CSc1nc2ccccc2c(=O)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G17 compound treatment 69120.0 5320.0 0.09 85640.0 28400.0 0.45 0.3818 0.8289 3179617 Maybridge4_002965 O=c1ss/c(=N/Cc2ccccc2)/n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G18 compound treatment 52560.0 -11200.0 -0.19 98680.0 41400.0 0.66 0.3355 0.4893 3064083 Maybridge4_002966 S=C(NCC1CC1)NCc2csc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G19 compound treatment 22960.0 -40800.0 -0.67 41360.0 -15900.0 -0.25 -0.6561 -0.9108 1378931 Maybridge4_002967 C(NC1CCCCC1)C(CNC2CCCCC2)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G20 compound treatment 108320.0 44500.0 0.73 102480.0 45200.0 0.72 1.0291 1.0 3064084 Maybridge4_002968 CC(C)(C)c1ccc(NC(=O)c2cnccn2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G21 compound treatment 97320.0 33500.0 0.55 90880.0 33600.0 0.54 0.77 0.9999 1050158 Maybridge4_002969 COc1ccc2C3CCC4(C)C(CCC4=O)C3CCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G22 compound treatment 7040.0 -56800.0 -0.94 8400.0 -48900.0 -0.78 -1.2133 -0.9958 1218870 Maybridge4_002970 O=C(Nc1cccnc1)c2cc3CCc4ccccc4-c3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G23 mock treatment 55880.0 -7920.0 -0.13 75080.0 17800.0 0.28 0.1082 0.3463 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 G24 mock treatment 35080.0 -28700.0 -0.47 48240.0 -9030.0 -0.14 -0.437 -0.882 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H01 compound treatment 41600.0 -22200.0 -0.37 55640.0 -1630.0 -0.03 -0.2775 -0.7554 1264780 Maybridge4_002971 COc1ccc(NC(=O)C2CC(=C(C)CC2C(=O)O)C)c(n1)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H02 compound treatment 44000.0 -19800.0 -0.33 61000.0 3730.0 0.06 -0.1891 -0.5692 1569864 Maybridge4_002972 COc1ccc(COCC(O)CS(=O)(=O)Cc2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H03 compound treatment 117640.0 53800.0 0.89 91440.0 34200.0 0.54 1.0135 0.9724 1169171 Maybridge4_002973 OCCNN1C(=O)c2cccc3cccc(C1=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H04 compound treatment 109960.0 46200.0 0.76 126560.0 69300.0 1.1 1.3197 0.9836 1600308 Maybridge4_002974 Cc1onc(c1C2=NCCO2)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H05 compound treatment 78800.0 15000.0 0.25 63000.0 5730.0 0.09 0.2396 0.9081 3179618 Maybridge4_002975 Cc1cccc(C)c1Nc2nc3c(C)cc(C)c(C)c3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H06 compound treatment 129840.0 66000.0 1.09 124680.0 67400.0 1.07 1.5305 1.0 1417835 Maybridge4_002976 OC1CCCCC1S(=O)(=O)Cc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H07 compound treatment 31520.0 -32300.0 -0.53 32840.0 -24400.0 -0.39 -0.6522 -0.9881 3064223 Maybridge4_002977 CCC(CO)NC(=S)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H08 compound treatment 147160.0 83400.0 1.38 165160.0 108000.0 1.72 2.1889 0.9939 3179619 Maybridge4_002978 Clc1ccc2oc(=S)n(Cc3ccccc3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H09 compound treatment 132200.0 68400.0 1.13 152560.0 95300.0 1.52 1.8723 0.9893 3064225 Maybridge4_002979 CNC(=S)NCCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H10 compound treatment 142840.0 79000.0 1.3 140160.0 82900.0 1.32 1.8567 1.0 3179620 Maybridge4_002980 O=C(OCc1ccc2OCOc2c1)OCc3ccc4OCOc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H11 compound treatment 153200.0 89400.0 1.48 145160.0 87900.0 1.4 2.034 0.9997 3179621 Maybridge4_002981 Cc1cc(C)nc(NC(=S)c2ccc(NC(=O)/C=C/C(=O)O)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H12 compound treatment 160880.0 97100.0 1.6 143200.0 85900.0 1.37 2.1016 0.9969 3064227 Maybridge4_002982 NC(=N)c1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H13 compound treatment 148320.0 84500.0 1.4 152120.0 94800.0 1.51 2.0555 0.9992 1447884 Maybridge4_002983 COc1cccc(C(=O)OCC(=O)c2ccccc2)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H14 compound treatment 121040.0 57200.0 0.94 118880.0 61600.0 0.98 1.3624 0.9998 3179622 Maybridge4_002984 CCOC(=O)c1cc(nc(S)c1C#N)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H15 compound treatment 41400.0 -22400.0 -0.37 35600.0 -21700.0 -0.35 -0.5057 -0.9994 2077819 Maybridge4_002985 C[n+]1c(NC2CCCCC2)scc1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H16 compound treatment 95080.0 31300.0 0.52 98000.0 40700.0 0.65 0.8241 0.9936 1009495 Maybridge4_002986 CC(C)(C)C1=CC(=O)C(=CC1=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H17 compound treatment 139640.0 75800.0 1.25 118880.0 61600.0 0.98 1.5795 0.9928 3179623 Maybridge4_002987 CCc1ccc(NC(=N)NC(=N)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H18 compound treatment 67840.0 4040.0 0.07 56360.0 -911.0 -0.01 0.0369 0.5403 1395086 Maybridge4_002988 Cc1nc(nc(O)c1Cl)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H19 compound treatment 120320.0 56500.0 0.93 136960.0 79700.0 1.27 1.5578 0.9885 1725570 Maybridge4_002989 CC(C)(C)C(=O)Nc1ccc(cc1)c2cc3cc(Cl)ccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H20 compound treatment 11160.0 -52600.0 -0.87 7200.0 -50100.0 -0.8 -1.1788 -0.9991 1661405 Maybridge4_002990 Cc1ccc(NC(=S)C(C#N)C(=O)N)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H21 compound treatment 90200.0 26400.0 0.44 68880.0 11600.0 0.19 0.439 0.9272 1723738 Maybridge4_002991 Clc1ccc(N2C(CC(=O)NC2=S)c3ccccc3)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H22 compound treatment 110720.0 46900.0 0.77 110920.0 53600.0 0.86 1.1523 0.9988 3179624 Maybridge4_002992 OCc1noc(n1)c2ccc(Cl)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H23 mock treatment 71080.0 7280.0 0.12 102840.0 45600.0 0.73 0.5985 0.813 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 H24 mock treatment 33160.0 -30600.0 -0.51 38600.0 -18700.0 -0.3 -0.5681 -0.968 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I01 compound treatment 6040.0 -57800.0 -0.95 3800.0 -53500.0 -0.85 -1.2769 -0.9984 1401560 Maybridge4_002993 Clc1ccc(NC(=O)Nc2ccccc2)c(SCc3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I02 compound treatment 23280.0 -40500.0 -0.67 23720.0 -33600.0 -0.53 -0.8511 -0.9938 1509609 Maybridge4_002994 CCSc1nnc2nc3c4ccccc4c5ccccc5c3nn12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I03 compound treatment 5680.0 -58100.0 -0.96 5240.0 -52000.0 -0.83 -1.2648 -0.9974 3179625 Maybridge4_002995 O=C/1N(N=C(Nc2ccccc2)\C1=C\Nc3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I04 compound treatment 7640.0 -56200.0 -0.93 6960.0 -50300.0 -0.8 -1.2226 -0.9974 3064579 Maybridge4_002996 Cn1cnnc1S/C=C/C(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I05 compound treatment 123560.0 59800.0 0.99 122000.0 64700.0 1.03 1.427 0.9997 1063036 Maybridge4_002997 COc1cc(c(OC)cc1C(C)(C)C)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I06 compound treatment 123560.0 59800.0 0.99 110280.0 53000.0 0.84 1.2949 0.997 3179626 Maybridge4_002998 CSc1ccc(cc1)C2N[C@@H](C(=O)O)C(C)(C)S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I07 compound treatment 48440.0 -15400.0 -0.25 46400.0 -10900.0 -0.17 -0.3018 -0.9828 1248980 Maybridge4_002999 CCNS(=O)(=O)c1ccc(cc1)c2oc3cc(ccc3c2Cl)S(=O)(=O)NCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I08 compound treatment 108640.0 44800.0 0.74 108680.0 51400.0 0.82 1.1027 0.9987 3064580 Maybridge4_003000 O=C/1N2CCCCSC2=N\C1=C\c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I09 compound treatment 111160.0 47400.0 0.78 99560.0 42300.0 0.67 1.0294 0.9973 1326747 Maybridge4_003001 CN(C)c1ccc(cc1)C2Nc3[nH]nc(C)c3C4=C2C(=O)CCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I10 compound treatment 124280.0 60500.0 1.0 117520.0 60200.0 0.96 1.3849 0.9998 3179627 Maybridge4_003002 S=c1[nH]nc(c2ccccc2)c(c1C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I11 compound treatment 151920.0 88100.0 1.45 141200.0 83900.0 1.34 1.9744 0.9991 3063889 Maybridge4_003003 COc1ccc2CC(=O)CCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I12 compound treatment 81000.0 17200.0 0.28 82560.0 25300.0 0.4 0.4857 0.9853 1333404 Maybridge4_003004 CCCC1C2C(ON1c3ccc(Cl)c(Cl)c3)C(=O)N(C2=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I13 compound treatment 117640.0 53800.0 0.89 96320.0 39000.0 0.62 1.0685 0.9848 3063891 Maybridge4_003005 CC(C)CC(C(=O)c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I14 compound treatment 117840.0 54000.0 0.89 118000.0 60700.0 0.97 1.3152 0.9992 1366549 Maybridge4_003006 Clc1cc(Cl)cc(c1)N2C(=O)CC(C2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I15 compound treatment 116120.0 52300.0 0.86 126040.0 68800.0 1.1 1.3857 0.993 1552090 Maybridge4_003007 O=c1c(coc2ccccc12)c3nnn[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I16 compound treatment 91680.0 27900.0 0.46 93880.0 36600.0 0.58 0.738 0.9931 1232818 Maybridge4_003008 CSc1nc2ccccc2c(=O)n1CC(=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I17 compound treatment 119680.0 55900.0 0.92 108080.0 50800.0 0.81 1.2248 0.9979 3063892 Maybridge4_003009 COc1cc2ccc(=O)oc2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I18 compound treatment 96080.0 32300.0 0.53 84760.0 27500.0 0.44 0.6866 0.9953 3063893 Maybridge4_003010 CN/1\C(=N/C(=O)C)\NC(=O)\C1=C/c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I19 compound treatment 87040.0 23200.0 0.38 97120.0 39800.0 0.64 0.7203 0.9708 1630014 Maybridge4_003011 NC(CCc1ccccc1Cl)c2ccc3OCCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I20 compound treatment 108120.0 44300.0 0.73 35400.0 -21900.0 -0.35 0.2708 0.3342 1530797 Maybridge4_003012 CCC1(CC)COC2(OC1)C(=O)Nc3ccc(F)cc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I21 compound treatment 20840.0 -43000.0 -0.71 17360.0 -39900.0 -0.64 -0.9513 -0.9985 3063895 Maybridge4_003013 Cc1cc(oc2cc3ccccc3c12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I22 compound treatment 103240.0 39400.0 0.65 120280.0 63000.0 1.0 1.1705 0.978 3179717 Maybridge4_003014 Cc1cccc(c1)n2ncc3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I23 mock treatment 105840.0 42000.0 0.69 64720.0 7450.0 0.12 0.5746 0.8162 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 I24 mock treatment 45200.0 -18600.0 -0.31 45440.0 -11800.0 -0.19 -0.3505 -0.9726 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J01 compound treatment 65120.0 1320.0 0.02 42160.0 -15100.0 -0.24 -0.1549 -0.6407 1715355 Maybridge4_003015 OC(=O)COCC(=O)Nc1cnccn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J02 compound treatment 90040.0 26200.0 0.43 88040.0 30800.0 0.49 0.653 0.9981 1137874 Maybridge4_003016 Cc1cccc(C)c1n2c(n[nH]c2=S)C3CC4CCC3O4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J03 compound treatment 94200.0 30400.0 0.5 84680.0 27400.0 0.44 0.6637 0.9976 1593696 Maybridge4_003017 CN(C)N1C(=O)c2cccc3cccc(C1=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J04 compound treatment 127280.0 63500.0 1.05 75400.0 18100.0 0.29 0.9452 0.8696 3063897 Maybridge4_003018 CC(=O)Nc1ccc(Br)c(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J05 compound treatment 13960.0 -49800.0 -0.82 7280.0 -50000.0 -0.8 -1.1452 -0.9999 1249809 Maybridge4_003019 CC(C)c1ccc(Nc2nnns2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J06 compound treatment 115640.0 51800.0 0.86 94040.0 36800.0 0.59 1.0195 0.983 1591476 Maybridge4_003020 CCN(CC)c1nc2ccccc2c(=O)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J07 compound treatment 90000.0 26200.0 0.43 47040.0 -10200.0 -0.16 0.1905 0.4121 1593840 Maybridge4_003021 CCN(CC)C(=S)Oc1ccccc1C(=O)Nc2ccc(Cl)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J08 compound treatment 180880.0 117000.0 1.93 186840.0 130000.0 2.07 2.8268 0.9995 3063932 Maybridge4_003022 Clc1cc(Cl)cc(Oc2nc(ns2)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J09 compound treatment 139880.0 76100.0 1.26 99080.0 41800.0 0.67 1.3592 0.9561 1389101 Maybridge4_003023 OC(=O)CCC(=O)Nc1cccc(F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J10 compound treatment 140680.0 76900.0 1.27 90400.0 33100.0 0.53 1.2707 0.9245 3063933 Maybridge4_003024 Cc1nc(S)c(C#N)c(C)c1CCC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J11 compound treatment 157600.0 93800.0 1.55 122280.0 65000.0 1.04 1.8275 0.9809 3179718 Maybridge4_003025 Cc1nnc(Nc2cccc(Cl)c2C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J12 compound treatment 33000.0 -30800.0 -0.51 25880.0 -31400.0 -0.5 -0.7133 -1.0 3063934 Maybridge4_003026 CNC(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J13 compound treatment 59640.0 -4160.0 -0.07 50880.0 -6390.0 -0.1 -0.1206 -0.9816 1446584 Maybridge4_003027 Cc1cc(Br)ccc1NC(=S)Nc2cccc(NC(=O)c3ccccc3O)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J14 compound treatment 131520.0 67700.0 1.12 98000.0 40700.0 0.65 1.2494 0.9666 3179719 Maybridge4_003028 CCOC(=O)c1cc(nc(O)c1C#N)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J15 compound treatment 135480.0 71700.0 1.18 120320.0 63000.0 1.0 1.5472 0.9967 3063936 Maybridge4_003029 O=c1cc(nc2scc(c3ccccc3)n12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J16 compound treatment 33880.0 -29900.0 -0.49 27200.0 -30100.0 -0.48 -0.6882 -0.9999 3179720 Maybridge4_003030 CCOC(=O)NC(=S)Nc1ccc(cc1)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J17 compound treatment 138520.0 74700.0 1.23 96240.0 39000.0 0.62 1.3113 0.9496 3063937 Maybridge4_003031 Cc1nc(S)nc(O)c1CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J18 compound treatment 113320.0 49500.0 0.82 93600.0 36300.0 0.58 0.9874 0.9857 3179721 Maybridge4_003032 Sc1nnc([nH]1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J19 compound treatment 85680.0 21900.0 0.36 53120.0 -4150.0 -0.07 0.2086 0.5681 3063939 Maybridge4_003033 COc1ccc(CCn2c(=S)[nH]c3cc(ccc23)C(F)(F)F)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J20 compound treatment 143800.0 80000.0 1.32 139840.0 82600.0 1.32 1.8643 1.0 3179722 Maybridge4_003034 N#Cc1ccc(cc1)C2SCCCS2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J21 compound treatment 105360.0 41600.0 0.69 98680.0 41400.0 0.66 0.9518 0.9998 3179723 Maybridge4_003035 FC(F)(F)c1cccc(c1)N2C(CC(=O)NC2=S)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J22 compound treatment 89520.0 25700.0 0.42 65120.0 7850.0 0.13 0.3886 0.8781 3063940 Maybridge4_003036 Oc1nnc(n2cccc12)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J23 mock treatment 96360.0 32600.0 0.54 68200.0 10900.0 0.17 0.5032 0.8907 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 J24 mock treatment 48400.0 -15400.0 -0.25 43160.0 -14100.0 -0.22 -0.3388 -0.9981 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K01 compound treatment 19880.0 -43900.0 -0.73 7000.0 -50300.0 -0.8 -1.0792 -0.9988 1466072 Maybridge4_003037 CC(C)(C)c1ccc(CSCC(=O)Nc2ccccc2C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K02 compound treatment 47200.0 -16600.0 -0.27 34640.0 -22600.0 -0.36 -0.4488 -0.9908 1417054 Maybridge4_003038 COc1ccc(Cc2nc(n[nH]c2=S)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K03 compound treatment 73120.0 9320.0 0.15 57840.0 569.0 0.01 0.1152 0.7475 1566854 Maybridge4_003039 Cc1ccc(C(=O)Nc2ccccc2)c(C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K04 compound treatment 37920.0 -25900.0 -0.43 30400.0 -26900.0 -0.43 -0.605 -1.0 1404328 Maybridge4_003040 CCC1(CC)C(=O)c2cc3ccccc3cc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K05 compound treatment 129760.0 66000.0 1.09 98720.0 41400.0 0.66 1.237 0.9713 1489684 Maybridge4_003041 CNC(=O)c1ccccc1Sc2ccccc2C(=O)NC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K06 compound treatment 130600.0 66800.0 1.1 99000.0 41700.0 0.67 1.25 0.9707 3179724 Maybridge4_003042 NC(=N)/N=C(\N)/Nc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K07 compound treatment 68520.0 4720.0 0.08 54440.0 -2830.0 -0.05 0.0232 0.2573 3063986 Maybridge4_003043 COC(=O)c1c2ccccc2c(C)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K08 compound treatment 31160.0 -32600.0 -0.54 26840.0 -30400.0 -0.49 -0.724 -0.9986 3179725 Maybridge4_003044 COc1ccc(/C=C\2/N=C3SC(C)C(=O)N3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K09 compound treatment 87960.0 24200.0 0.4 26400.0 -30900.0 -0.49 -0.066 -0.1041 3063988 Maybridge4_003045 C/C(=C\c1ccccc1)/C(=N/O)/C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K10 compound treatment 113320.0 49500.0 0.82 63840.0 6570.0 0.1 0.652 0.7912 3179726 Maybridge4_003046 N#C/C(=C\C(=C\N1CCOCC1)\c2ccccc2)/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K11 compound treatment 143280.0 79500.0 1.31 130240.0 73000.0 1.16 1.7501 0.9982 1700846 Maybridge4_003047 CC(C)c1cc(C(C)C)c(c(c1)C(C)C)S(=O)(=O)n2ccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K12 compound treatment 150840.0 87000.0 1.44 140720.0 83400.0 1.33 1.9564 0.9993 1550463 Maybridge4_003048 O=C1CSCC(=O)N1c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K13 compound treatment 140520.0 76700.0 1.27 126080.0 68800.0 1.1 1.671 0.9974 1209004 Maybridge4_003049 COC(=O)C1=C(O)C2(CC(=C(O)C(C1)(C2)C(=O)O)C(=O)OC)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K14 compound treatment 148480.0 84700.0 1.4 110680.0 53400.0 0.85 1.5903 0.9717 3063990 Maybridge4_003050 FC(F)(F)Oc1ccc(/N=c/2\[nH]c(=O)c3ccccc3o2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K15 compound treatment 135000.0 71200.0 1.18 120400.0 63100.0 1.01 1.5425 0.997 3179727 Maybridge4_003051 FC(F)(F)c1ccc(Oc2ccc(Oc3ccc(cn3)C(F)(F)F)cc2)nc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K16 compound treatment 80840.0 17000.0 0.28 51440.0 -5830.0 -0.09 0.1331 0.4495 3063992 Maybridge4_003052 COC(=O)/C=C\1/NCC(CNC1=O)OC(=O)c2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K17 compound treatment 98360.0 34600.0 0.57 66520.0 9250.0 0.15 0.5076 0.8615 1628564 Maybridge4_003053 C1Cc2nc(ccc2-c3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K18 compound treatment 50800.0 -13000.0 -0.21 27800.0 -29500.0 -0.47 -0.4839 -0.937 3179728 Maybridge4_003054 CC1CC(CC(C)(C)C1)NC(=S)Nc2ccc(I)cc2F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K19 compound treatment 127000.0 63200.0 1.04 101440.0 44200.0 0.7 1.2355 0.9817 3063993 Maybridge4_003055 Cn1c(=O)n(C)c2ncn(CCCCn3cnc4n(C)c(=O)n(C)c(=O)c34)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K20 compound treatment 101960.0 38200.0 0.63 96880.0 39600.0 0.63 0.8918 1.0 3179729 Maybridge4_003056 CSc1cccc(c1)N2C(=O)C3CC=C(C)CC3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K21 compound treatment 103360.0 39600.0 0.65 80000.0 22700.0 0.36 0.7179 0.9614 1568172 Maybridge4_003057 OCC(C(O)c1ccccc1)N2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K22 compound treatment 19320.0 -44500.0 -0.73 12960.0 -44300.0 -0.71 -1.0186 -0.9998 1396421 Maybridge4_003058 NNC(=O)c1cc2CCc3ccccc3-c2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K23 mock treatment 77400.0 13600.0 0.22 77440.0 20200.0 0.32 0.386 0.9846 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 K24 mock treatment 89080.0 25300.0 0.42 24040.0 -33200.0 -0.53 -0.0795 -0.1179 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L01 compound treatment 78680.0 14900.0 0.25 39440.0 -17800.0 -0.28 -0.0273 -0.0727 3179730 Maybridge4_003059 Cc1c(sc2nc(nn12)C(F)(F)F)C(=O)Cc3c(O)c4ccccc4oc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L02 compound treatment 68240.0 4440.0 0.07 50640.0 -6630.0 -0.11 -0.0229 -0.1784 3063994 Maybridge4_003060 FC(F)(F)c1cc(cc(c1)C(F)(F)F)N2C(=O)CC3(CCCC3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L03 compound treatment 51560.0 -12200.0 -0.2 37920.0 -19400.0 -0.31 -0.361 -0.979 3179731 Maybridge4_003061 CCOc1ccc(Br)cc1/C=N/c2ccc3OCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L04 compound treatment 92880.0 29100.0 0.48 59000.0 1730.0 0.03 0.3589 0.7465 1505741 Maybridge4_003062 CC(C)c1ccc(NS(=O)(=O)c2ccc(cc2)N3C(=O)CCC3=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L05 compound treatment 114400.0 50600.0 0.84 81040.0 23800.0 0.38 0.8585 0.936 3064031 Maybridge4_003063 Nc1ccccc1NC(=S)Nc2ccccc2C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L06 compound treatment 154160.0 90400.0 1.49 98280.0 41000.0 0.65 1.5169 0.9315 3064032 Maybridge4_003064 CN(C)c1nc2ccccc2c(=O)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L07 compound treatment 168480.0 105000.0 1.73 126080.0 68800.0 1.1 1.9973 0.9759 3179732 Maybridge4_003065 CCN(CC)C(=S)Oc1ccc(I)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L08 compound treatment 136880.0 73100.0 1.21 104760.0 47500.0 0.76 1.3882 0.9748 3179733 Maybridge4_003066 FC(F)(F)c1cc(Cl)c2nc(cn2c1)C(=O)NC(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L09 compound treatment 149120.0 85300.0 1.41 83600.0 26300.0 0.42 1.2926 0.8796 1015049 Maybridge4_003067 CC(=O)Nc1ccc(Cl)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L10 compound treatment 152960.0 89200.0 1.47 78560.0 21300.0 0.34 1.2806 0.8479 3064035 Maybridge4_003068 CCOC(=O)/C(=N/O)/C1=NN=C(N)SC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L11 compound treatment 152040.0 88200.0 1.46 74240.0 17000.0 0.27 1.2212 0.8243 3179734 Maybridge4_003069 CC(C)Nc1nnc(C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L12 compound treatment 146120.0 82300.0 1.36 128560.0 71300.0 1.14 1.7643 0.996 3064037 Maybridge4_003070 CN(C)C(=O)Nc1cc(C)n(n1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L13 compound treatment 136480.0 72700.0 1.2 96640.0 39400.0 0.63 1.292 0.9543 3179735 Maybridge4_003071 Cc1cccc(C)c1/N=C/2\NC(C)(CO)CS2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L14 compound treatment 17000.0 -46800.0 -0.77 9520.0 -47800.0 -0.76 -1.0845 -1.0 1316254 Maybridge4_003072 Cc1cc2C(=O)NC(=O)c2c(Sc3ccc(Cl)cc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L15 compound treatment 149040.0 85200.0 1.41 89680.0 32400.0 0.52 1.3602 0.9075 3064038 Maybridge4_003073 Clc1ccc(cc1)c2csc3nc(cc(=O)n23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L16 compound treatment 106640.0 42800.0 0.71 27480.0 -29800.0 -0.47 0.1643 0.1928 1158628 Maybridge4_003074 CNC(=O)Nc1ccc(cc1Br)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L17 compound treatment 116400.0 52600.0 0.87 64560.0 7290.0 0.12 0.6961 0.7946 3064039 Maybridge4_003075 FC(F)(F)c1cc(cc(c1)C(F)(F)F)n2c(S)nc3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L18 compound treatment 93080.0 29300.0 0.48 46480.0 -10800.0 -0.17 0.2201 0.4291 1188106 Maybridge4_003076 Clc1cccc(Cl)c1c2nscc2NC(=O)NN3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L19 compound treatment 54640.0 -9160.0 -0.15 43440.0 -13800.0 -0.22 -0.2628 -0.9831 3064040 Maybridge4_003077 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2cn3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L20 compound treatment 7040.0 -56800.0 -0.94 4040.0 -53200.0 -0.85 -1.2625 -0.9988 3178150 Maybridge4_003078 CNC(=O)Oc1ccc(cc1)c2nc(CSc3ccc(Cl)cc3)cs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L21 compound treatment 5520.0 -58300.0 -0.96 3240.0 -54000.0 -0.86 -1.2892 -0.9985 1216087 Maybridge4_003079 CC(C)c1ccc(NCC(O)CSc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L22 compound treatment 13960.0 -49800.0 -0.82 6440.0 -50800.0 -0.81 -1.1547 -1.0 3064086 Maybridge4_003080 OCc1nc(cs1)c2cc(cc(c2)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L23 mock treatment 81920.0 18100.0 0.3 52120.0 -5150.0 -0.08 0.1534 0.4947 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 L24 mock treatment 76480.0 12700.0 0.21 30800.0 -26500.0 -0.42 -0.1504 -0.3193 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M01 compound treatment 51720.0 -12100.0 -0.2 25240.0 -32000.0 -0.51 -0.502 -0.9159 1228182 Maybridge4_003081 O=C(Nc1ccc2OCOc2c1)C(=S)NCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M02 compound treatment 99080.0 35300.0 0.58 50840.0 -6430.0 -0.1 0.3393 0.5738 3064088 Maybridge4_003082 CCOC(=O)CSc1nnc(c2ccccc2)c(=O)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M03 compound treatment 38800.0 -25000.0 -0.41 28680.0 -28600.0 -0.46 -0.6141 -0.9988 3178151 Maybridge4_003083 CC1(C)OC(=O)C(=Cc2ccoc2)C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M04 compound treatment 102600.0 38800.0 0.64 65240.0 7970.0 0.13 0.5427 0.8312 3178152 Maybridge4_003084 C[C@]1(O)CCC2C3CC[C@H]4CC(=O)/C(=C/c5ccccc5)/CC4(C)C3CCC21C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M05 compound treatment 114880.0 51100.0 0.84 63000.0 5730.0 0.09 0.6608 0.7791 2077623 Maybridge4_003085 CNC(=O)c1ccccc1[S+]2N(C)C(=O)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M06 compound treatment 124920.0 61100.0 1.01 63280.0 6010.0 0.1 0.7811 0.7708 3064090 Maybridge4_003086 Cc1ccc(cc1)C(=O)/C=C/Nc2ccc(cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M07 compound treatment 127040.0 63200.0 1.04 43120.0 -14200.0 -0.23 0.5786 0.5418 3064091 Maybridge4_003087 FC(F)(F)C(=O)N1CCCc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M08 compound treatment 133920.0 70100.0 1.16 60840.0 3570.0 0.06 0.8587 0.741 3178153 Maybridge4_003088 CN(C)/C=C/C=C/1\N=C(OC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M09 compound treatment 143760.0 80000.0 1.32 74680.0 17400.0 0.28 1.1295 0.8375 1045240 Maybridge4_003089 O(c1ccccc1)c2nc(Oc3ccccc3)nc(Oc4ccccc4)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M10 compound treatment 152520.0 88700.0 1.46 89080.0 31800.0 0.51 1.394 0.8995 1341049 Maybridge4_003090 Oc1c(Cc2ccccc2)c(=O)n(c3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M11 compound treatment 58720.0 -5080.0 -0.08 24680.0 -32600.0 -0.52 -0.4266 -0.8108 1250198 Maybridge4_003091 CCN1c2cc(NC(=O)CC)ccc2C(C)CC1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M12 compound treatment 134960.0 71200.0 1.17 123520.0 66200.0 1.06 1.5772 0.9986 1276296 Maybridge4_003092 COC(=O)c1cc(=O)n2CCSc2c1C(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M13 compound treatment 75440.0 11600.0 0.19 57520.0 249.0 0.0 0.1386 0.7215 1660543 Maybridge4_003093 CCC(C)c1cc(N)nc2nc3ccccc3n12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M14 compound treatment 138360.0 74600.0 1.23 93440.0 36200.0 0.58 1.2779 0.9403 1341769 Maybridge4_003094 Fc1ccc(cc1)N2C(=O)CC(C2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M15 compound treatment 150240.0 86400.0 1.43 101720.0 44400.0 0.71 1.5099 0.9478 3178154 Maybridge4_003095 CCOC(=O)CCc1c(CC(=O)OCC)c[nH]c1/C=N/O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M16 compound treatment 14080.0 -49700.0 -0.82 5640.0 -51600.0 -0.82 -1.1623 -1.0 3064093 Maybridge4_003096 OC(=O)c1ccccc1SC(CC(=O)c2ccc(F)cc2)c3ccc(F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M17 compound treatment 14760.0 -49000.0 -0.81 6160.0 -51100.0 -0.81 -1.1485 -1.0 3178155 Maybridge4_003097 Clc1ccccc1N/C=C\C2=NN=NC2c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M18 compound treatment 122480.0 58700.0 0.97 62360.0 5090.0 0.08 0.7423 0.7636 3064095 Maybridge4_003098 CN(C)NC(=S)NCc1ccc(F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M19 compound treatment 8120.0 -55700.0 -0.92 3920.0 -53400.0 -0.85 -1.2512 -0.9992 3178156 Maybridge4_003099 CC(=O)OC1CCC2C3CC[C@H]4C[C@@H]5C[C@@H]5[C@H](O)C4(C)C3CCC12C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M20 compound treatment 103600.0 39800.0 0.66 44600.0 -12700.0 -0.2 0.3217 0.4681 1273753 Maybridge4_003100 S=C(N1CCN(Cc2ccccc2)CC1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M21 compound treatment 12400.0 -51400.0 -0.85 3000.0 -54300.0 -0.87 -1.2116 -1.0 3064162 Maybridge4_003101 CCOC(=O)/N=C(/c1ccc(Cl)cc1)\c2cc3ccccc3cn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M22 compound treatment 66120.0 2320.0 0.04 31120.0 -26200.0 -0.42 -0.2677 -0.6395 1623253 Maybridge4_003102 CCOC(=O)CC(Sc1ccccc1N)c2cc(OC)c(OC)c(OC)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M23 mock treatment 96160.0 32400.0 0.53 48080.0 -9190.0 -0.15 0.2741 0.4949 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 M24 mock treatment 54320.0 -9480.0 -0.16 28120.0 -29200.0 -0.46 -0.4392 -0.8959 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N01 compound treatment 7800.0 -56000.0 -0.92 5280.0 -52000.0 -0.83 -1.2396 -0.9985 3178157 Maybridge4_003103 CN(C)c1ccc(/C=C(\C#N)/c2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N02 compound treatment 88520.0 24700.0 0.41 33920.0 -23400.0 -0.37 0.0253 0.0459 3178158 Maybridge4_003104 FC(F)(F)Oc1ccc(OCc2n[nH]c(=S)o2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N03 compound treatment 7200.0 -56600.0 -0.93 3160.0 -54100.0 -0.86 -1.2705 -0.9992 1090055 Maybridge4_003105 CC(C)c1ccc(cc1)N2Cc3cc(ccc3N=C2)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N04 compound treatment 121160.0 57400.0 0.95 45000.0 -12300.0 -0.2 0.5312 0.5494 3064190 Maybridge4_003106 FC(F)(F)Oc1ccc(OC(=O)C2=Cc3cc(Cl)ccc3OC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N05 compound treatment 96960.0 33200.0 0.55 45440.0 -11800.0 -0.19 0.2537 0.4382 3178159 Maybridge4_003107 Cc1cc(Cl)ccc1NC(=N)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N06 compound treatment 10280.0 -53500.0 -0.88 4320.0 -53000.0 -0.84 -1.2215 -0.9997 3178160 Maybridge4_003108 FC(F)(F)c1cnc(NCCNC(=O)C(F)(F)Sc2ccccc2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N07 compound treatment 155120.0 91300.0 1.51 64880.0 7610.0 0.12 1.1516 0.7615 3064194 Maybridge4_003109 CCN(CC)C(=S)Oc1ccc(C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N08 compound treatment 89800.0 26000.0 0.43 36080.0 -21200.0 -0.34 0.0646 0.1183 3064195 Maybridge4_003110 CC(C)(C)CC(C)(C)NC(=O)c1cccc(/N=C/c2ccccc2O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N09 compound treatment 14560.0 -49200.0 -0.81 4280.0 -53000.0 -0.84 -1.172 -0.9998 1463402 Maybridge4_003111 CCc1ccccc1NC(=S)Nc2ccc(Oc3ccc(Cl)cc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N10 compound treatment 17320.0 -46500.0 -0.77 12560.0 -44700.0 -0.71 -1.0465 -0.9993 3064198 Maybridge4_003112 Clc1ccc(SC(=S)NC2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N11 compound treatment 13400.0 -50400.0 -0.83 13160.0 -44100.0 -0.7 -1.0855 -0.9965 1288025 Maybridge4_003113 Clc1ccc(cc1)C(=O)COC(=O)c2ccccc2NCc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N12 compound treatment 112880.0 49100.0 0.81 90920.0 33600.0 0.54 0.9521 0.9799 3064199 Maybridge4_003114 OC(=O)c1cc(O)nc2c(cccc12)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N13 compound treatment 45560.0 -18200.0 -0.3 33760.0 -23500.0 -0.37 -0.4779 -0.9941 3178161 Maybridge4_003115 CC1CCCC(C)N1C(=S)NCCCN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N14 compound treatment 107040.0 43200.0 0.71 69520.0 12200.0 0.2 0.6427 0.8686 3178162 Maybridge4_003116 CCOC(=O)c1cc(nc(OC(=O)N(C)C)c1C#N)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N15 compound treatment 137560.0 73800.0 1.22 51360.0 -5910.0 -0.09 0.7943 0.6504 3064201 Maybridge4_003117 COc1ccc(/N=C/2\SCC(=O)N2CCc3ccc(OC)c(OC)c3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N16 compound treatment 150000.0 86200.0 1.42 57680.0 409.0 0.01 1.0107 0.7103 3178163 Maybridge4_003118 Clc1cn(CCC#N)cc(Cl)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N17 compound treatment 154160.0 90400.0 1.49 54560.0 -2710.0 -0.04 1.0241 0.6863 3064203 Maybridge4_003119 CC1=NNC(=O)C1Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N18 compound treatment 118200.0 54400.0 0.9 29480.0 -27800.0 -0.44 0.3217 0.3213 1440599 Maybridge4_003120 CCOC(=O)Cn1c(noc1=O)c2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N19 compound treatment 121360.0 57600.0 0.95 25680.0 -31600.0 -0.5 0.3158 0.2937 3178164 Maybridge4_003121 Cc1cc(C)c(OC(=O)/C=C/c2cccs2)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N20 compound treatment 110120.0 46300.0 0.76 40000.0 -17300.0 -0.28 0.346 0.4258 3064205 Maybridge4_003122 CSc1nc(NC(=O)NS(=O)(=O)c2ccccc2C(F)(F)F)nc(n1)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N21 compound treatment 6160.0 -57600.0 -0.95 2320.0 -55000.0 -0.88 -1.2921 -0.9991 1468063 Maybridge4_003123 CC(C)c1ccc(NCC(O)COc2ccc(Cl)c(Cl)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N22 compound treatment 94200.0 30400.0 0.5 36000.0 -21300.0 -0.34 0.1151 0.19 3064206 Maybridge4_003124 O=C1CNC(=S)N1CCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N23 mock treatment 98600.0 34800.0 0.57 37880.0 -19400.0 -0.31 0.1876 0.2876 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 N24 mock treatment 71680.0 7880.0 0.13 29800.0 -27500.0 -0.44 -0.2177 -0.4765 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O01 compound treatment 55160.0 -8640.0 -0.14 40960.0 -16300.0 -0.26 -0.2847 -0.9601 1118081 Maybridge4_003125 NNC(=O)CNc1ccc2OCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O02 compound treatment 6040.0 -57800.0 -0.95 2320.0 -55000.0 -0.88 -1.2935 -0.9991 3178165 Maybridge4_003126 CCOC(=O)c1cnc(S/C=C/C(=O)c2ccc(C)cc2)nc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O03 compound treatment 123000.0 59200.0 0.98 41720.0 -15600.0 -0.25 0.5157 0.5115 1121873 Maybridge4_003127 OC(=O)c1ccccc1S(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O04 compound treatment 26200.0 -37600.0 -0.62 6920.0 -50400.0 -0.8 -1.0064 -0.9919 3064232 Maybridge4_003128 Clc1ccc(cc1)C(=O)O/C=C/C(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O05 compound treatment 142400.0 78600.0 1.3 42400.0 -14900.0 -0.24 0.7498 0.5685 3178166 Maybridge4_003129 CNC(=O)c1cccc2cccc(Br)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O06 compound treatment 105120.0 41300.0 0.68 34000.0 -23300.0 -0.37 0.22 0.2834 3178167 Maybridge4_003130 COc1ccc(cc1)C(=O)/C=C/Nc2ccc(cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O07 compound treatment 144280.0 80500.0 1.33 29040.0 -28200.0 -0.45 0.6212 0.4429 3064235 Maybridge4_003131 N#CN=C(NC1CCCCC1)NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O08 compound treatment 17880.0 -45900.0 -0.76 7680.0 -49600.0 -0.79 -1.0949 -0.9998 3178168 Maybridge4_003132 Fc1ccc(cc1)C(=O)/C=C/Sc2nc3cc(Cl)ccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O09 compound treatment 102000.0 38200.0 0.63 30640.0 -26600.0 -0.42 0.1457 0.1917 1715504 Maybridge4_003133 CN1C(=O)C(Cc2ccccc2)(c3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O10 compound treatment 183160.0 119000.0 1.97 40840.0 -16400.0 -0.26 1.208 0.6078 1565110 Maybridge4_003134 CN(C)C(=O)Oc1cc(C)n(C)c(=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O11 compound treatment 123480.0 59700.0 0.99 60720.0 3450.0 0.05 0.7354 0.7454 3064240 Maybridge4_003135 C/C=C(\C(=N\O)\C)/c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O12 compound treatment 70920.0 7120.0 0.12 35880.0 -21400.0 -0.34 -0.158 -0.4382 1124022 Maybridge4_003136 CC(=O)n1c(cc(c(C#N)c1=O)c2ccc(C)cc2)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O13 compound treatment 72000.0 8200.0 0.14 52680.0 -4590.0 -0.07 0.0439 0.2856 1736617 Maybridge4_003137 COc1ccc(cc1)c2nc([nH]c(=O)c2C#N)N(C)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O14 compound treatment 10320.0 -53500.0 -0.88 4640.0 -52600.0 -0.84 -1.2174 -0.9997 3178250 Maybridge4_003138 FC(F)(F)c1ccc(/C=C(\C#N)/c2c[nH]c3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O15 compound treatment 184480.0 121000.0 1.99 46520.0 -10800.0 -0.17 1.2874 0.6439 1429244 Maybridge4_003139 CCOC(=O)Cc1c(C)[nH]c(C(=O)OCC)c1CC(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O16 compound treatment 32480.0 -31300.0 -0.52 8240.0 -49000.0 -0.78 -0.9182 -0.9799 1373405 Maybridge4_003140 CC(=O)SC1CC(=O)N(C1=O)c2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O17 compound treatment 110600.0 46800.0 0.77 23960.0 -33300.0 -0.53 0.1708 0.1822 3178251 Maybridge4_003141 O=C(C/C(=C\1/Cc2ccccc2C1=O)/c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O18 compound treatment 132200.0 68400.0 1.13 43640.0 -13600.0 -0.22 0.6447 0.5608 3064242 Maybridge4_003142 CN(C)NC(=S)NCc1ccc(C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O19 compound treatment 7320.0 -56500.0 -0.93 2440.0 -54800.0 -0.87 -1.2772 -0.9995 3178252 Maybridge4_003143 CCOC(=O)OC1CCC2C3CCC4=CC(=O)C(=C)CC4(C)C3CCC12C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O20 compound treatment 24320.0 -39500.0 -0.65 8280.0 -49000.0 -0.78 -1.013 -0.996 1442612 Maybridge4_003144 Cc1cc(NCn2ncc3ccccc3c2=O)ccc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O21 compound treatment 64880.0 1080.0 0.02 31440.0 -25800.0 -0.41 -0.2785 -0.6759 3178253 Maybridge4_003145 Brc1ccc(cc1)c2cnc(/C=C/C=C/N3CCOCC3)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O22 compound treatment 63480.0 -323.0 -0.01 16520.0 -40800.0 -0.65 -0.463 -0.7129 1286622 Maybridge4_003146 O=C1c2ccccc2-c3c1c4ccccc4c(=O)n3CC5CC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O23 mock treatment 103320.0 39500.0 0.65 45200.0 -12100.0 -0.19 0.3252 0.4782 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 O24 mock treatment 75320.0 11500.0 0.19 48120.0 -9150.0 -0.15 0.0313 0.1306 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P01 compound treatment 9440.0 -54400.0 -0.9 16280.0 -41000.0 -0.65 -1.0965 -0.9878 3178254 Maybridge4_003147 COc1ccc(/C=C(\C#N)/c2ccc(OC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P02 compound treatment 28400.0 -35400.0 -0.58 27320.0 -30000.0 -0.48 -0.7508 -0.995 1202102 Maybridge4_003148 COc1ccc(cc1OC)C2SC(=S)NC(=C2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P03 compound treatment 63320.0 -483.0 -0.01 36440.0 -20800.0 -0.33 -0.2404 -0.7239 3178255 Maybridge4_003149 O=C(NC(=S)N1CCCCC1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P04 compound treatment 10840.0 -53000.0 -0.87 5000.0 -52300.0 -0.83 -1.2073 -0.9997 3178256 Maybridge4_003150 Cc1cc(Sc2ccc(Cl)cc2)nc(n1)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P05 compound treatment 90120.0 26300.0 0.43 29200.0 -28100.0 -0.45 -0.0092 -0.0147 3064323 Maybridge4_003151 CCOC(=O)NC(=S)Nc1ccc(F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P06 compound treatment 110920.0 47100.0 0.78 19120.0 -38200.0 -0.61 0.12 0.1215 1496124 Maybridge4_003152 Nc1nc(Cc2ccc(F)cc2F)no1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P07 compound treatment 117800.0 54000.0 0.89 27440.0 -29800.0 -0.48 0.2941 0.2911 1646965 Maybridge4_003153 Oc1cc(O)n(Cc2ccco2)c(=S)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P08 compound treatment 105160.0 41400.0 0.68 33560.0 -23700.0 -0.38 0.2155 0.2762 3178257 Maybridge4_003154 COc1cc(NC(=O)C(Sc2nc(C)cc(C)c2C#N)c3ccccc3)c(OC)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P09 compound treatment 90600.0 26800.0 0.44 30280.0 -27000.0 -0.43 0.0086 0.0139 1555108 Maybridge4_003155 Sc1nc2ccccc2c(=O)n1CCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P10 compound treatment 125600.0 61800.0 1.02 31200.0 -26100.0 -0.42 0.4275 0.3881 1688911 Maybridge4_003156 CN(C(=O)N(C)C(=O)c1ccccc1)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P11 compound treatment 102200.0 38400.0 0.63 25040.0 -32200.0 -0.51 0.0849 0.1041 1186033 Maybridge4_003157 CCNC(=S)Nc1ccc(NC(=O)c2ccccc2O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P12 compound treatment 112840.0 49000.0 0.81 67320.0 10000.0 0.16 0.6856 0.8309 3064360 Maybridge4_003158 CN(C)/C=N/c1nonc1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P13 compound treatment 91640.0 27800.0 0.46 32160.0 -25100.0 -0.4 0.0419 0.0688 3178258 Maybridge4_003159 COc1ccccc1/C=C(\C#N)/c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P14 compound treatment 105120.0 41300.0 0.68 45280.0 -12000.0 -0.19 0.3471 0.4901 1641024 Maybridge4_003160 CC(C)NC(=O)Oc1noc2ccc(Cl)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P15 compound treatment 109280.0 45500.0 0.75 34200.0 -23100.0 -0.37 0.2708 0.324 3178259 Maybridge4_003161 CS/C(=N\c1c(C)cccc1C)/N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P16 compound treatment 80160.0 16400.0 0.27 32520.0 -24800.0 -0.39 -0.088 -0.1841 1687023 Maybridge4_003162 CC(C)(C)C(=O)Nc1cccc(c1)c2cc(no2)c3c(Cl)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P17 compound treatment 128520.0 64700.0 1.07 40320.0 -17000.0 -0.27 0.5644 0.5122 3064362 Maybridge4_003163 Cc1nc(S)nc(O)c1Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P18 compound treatment 60240.0 -3560.0 -0.06 20240.0 -37000.0 -0.59 -0.4589 -0.7737 1159384 Maybridge4_003164 COC(=O)c1c(NC(=O)NCc2ccccc2)onc1c3c(Cl)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P19 compound treatment 85280.0 21500.0 0.35 25480.0 -31800.0 -0.51 -0.1076 -0.174 1135236 Maybridge4_003165 Clc1ccc(cc1)C(=O)Oc2ccccc2OCC(=O)NCc3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P20 compound treatment 92840.0 29000.0 0.48 36360.0 -20900.0 -0.33 0.1033 0.1769 3178260 Maybridge4_003166 CSc1nc(NC(=O)NS(=O)(=O)Cc2ccc(Cl)cc2Cl)nc(n1)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P21 compound treatment 59440.0 -4360.0 -0.07 26840.0 -30400.0 -0.49 -0.3939 -0.8033 1287410 Maybridge4_003167 CSc1nc2ccccc2c(=O)n1c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P22 compound treatment 66840.0 3040.0 0.05 40080.0 -17200.0 -0.27 -0.1583 -0.5683 3178261 Maybridge4_003168 COC(=O)c1ccc(nc1)C(=O)Nc2ccc(cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P23 mock treatment 66840.0 3040.0 0.05 40520.0 -16800.0 -0.27 -0.1533 -0.5644 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2057 P24 mock treatment 42200.0 -21600.0 -0.36 41960.0 -15300.0 -0.24 -0.4247 -0.9829 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A01 compound treatment 10800.0 -27600.0 -0.45 54920.0 9460.0 0.15 -0.215 -0.4486 3064365 Maybridge4_003169 Clc1ccccc1CN2C(=O)CNC2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A02 compound treatment 38840.0 486.0 0.01 48400.0 2940.0 0.05 0.0389 0.8162 3178262 Maybridge4_003170 Cc1cc(SCC(=O)NN)c(C)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A03 compound treatment 46720.0 8370.0 0.14 36600.0 -8860.0 -0.14 -0.0022 -0.0109 1123055 Maybridge4_003171 Clc1ccccc1OCCN2C(=O)CNC2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A04 compound treatment 49800.0 11400.0 0.19 39520.0 -5940.0 -0.09 0.0667 0.3157 3178263 Maybridge4_003172 CC(=O)N1c2ccccc2C=Cc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A05 compound treatment 55480.0 17100.0 0.28 15840.0 -29600.0 -0.47 -0.1339 -0.2433 3178264 Maybridge4_003173 COc1nc(NC(=O)NS(=O)(=O)Nc2cccc3cccnc23)nc(OC)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A06 compound treatment 56200.0 17800.0 0.29 12240.0 -33200.0 -0.53 -0.166 -0.2741 1697760 Maybridge4_003174 S=C(NC1CC2CC1C=C2)Nc3ccc4[nH]ccc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A07 compound treatment 94400.0 56000.0 0.93 10920.0 -34500.0 -0.55 0.265 0.2461 3064405 Maybridge4_003175 CNc1nc2c(Cl)cc(Cl)cc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A08 compound treatment 11360.0 -27000.0 -0.45 1720.0 -43700.0 -0.7 -0.808 -0.9766 3064407 Maybridge4_003176 CC(C)OC(=S)Nc1cccc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A09 compound treatment 107600.0 69200.0 1.14 28640.0 -16800.0 -0.27 0.6187 0.527 3178265 Maybridge4_003177 CCN(C(=O)c1cnccc1C(F)(F)F)c2c(C)cccc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A10 compound treatment 169360.0 131000.0 2.16 30320.0 -15100.0 -0.24 1.3586 0.6244 1316937 Maybridge4_003178 Cc1ccc(C)c(COc2ccc(C)nc2NC(=S)NCc3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A11 compound treatment 179160.0 141000.0 2.32 44480.0 -976.0 -0.02 1.6325 0.7024 3064408 Maybridge4_003179 CC1(C)ONC(=O)N(C1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A12 compound treatment 50960.0 12600.0 0.21 13200.0 -32300.0 -0.51 -0.2164 -0.3901 1490878 Maybridge4_003180 COc1ccccc1C2CCN(CC2)C(=O)c3cccnc3Sc4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A13 compound treatment 166720.0 128000.0 2.12 31880.0 -13600.0 -0.22 1.3453 0.6316 3064412 Maybridge4_003181 FC(F)(F)c1cccc(c1)n2c(noc2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A14 compound treatment 7320.0 -31000.0 -0.51 2920.0 -42500.0 -0.68 -0.8416 -0.9905 1158023 Maybridge4_003182 Sc1nnc(CSCc2cccc3ccccc23)n1C4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A15 compound treatment 57000.0 18600.0 0.31 11840.0 -33600.0 -0.54 -0.1612 -0.2609 3064413 Maybridge4_003183 Brc1ccc(cc1)C(=O)CSc2nc(c3cccs3)c(C#N)c(=O)[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A16 compound treatment 83840.0 45500.0 0.75 20560.0 -24900.0 -0.4 0.2503 0.2948 1059941 Maybridge4_003184 OC(=O)c1cc2cc(Cl)ccc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A17 compound treatment 5480.0 -32900.0 -0.54 1440.0 -44000.0 -0.7 -0.8798 -0.9919 3178266 Maybridge4_003185 Cc1cc(C)cc(Sc2ccc3nnc(c4ccccc4)n3n2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A18 compound treatment 5040.0 -33300.0 -0.55 1520.0 -43900.0 -0.7 -0.884 -0.9928 3178267 Maybridge4_003186 CC(C)c1ccc(/C=C/2\CSc3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A19 compound treatment 123680.0 85300.0 1.41 31160.0 -14300.0 -0.23 0.8348 0.5851 3064415 Maybridge4_003187 Cc1cc(Cc2ccc(Cl)cc2)c(=O)[nH]n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A20 compound treatment 49680.0 11300.0 0.19 26680.0 -18800.0 -0.3 -0.0794 -0.225 3178268 Maybridge4_003188 O=C(/C=C\1/Nc2ccccc2OC1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A21 compound treatment 71440.0 33100.0 0.55 48880.0 3420.0 0.05 0.4248 0.7739 3064418 Maybridge4_003189 CCOC(=O)CSc1nc2cccnc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A22 compound treatment 15240.0 -23100.0 -0.38 14640.0 -30800.0 -0.49 -0.6171 -0.9922 3178269 Maybridge4_003190 COc1ccc(cc1)C2=Nc3ccccc3SC(C2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A23 mock treatment 48440.0 10100.0 0.17 44280.0 -1180.0 -0.02 0.1045 0.6235 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 A24 mock treatment 21240.0 -17100.0 -0.28 59400.0 13900.0 0.22 -0.0426 -0.1185 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B01 compound treatment 41680.0 3330.0 0.05 40000.0 -5460.0 -0.09 -0.0227 -0.2204 1225177 Maybridge4_003191 CCOC(=O)c1c(C)c(=O)oc2n(nc(O)c12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B02 compound treatment 10520.0 -27800.0 -0.46 3880.0 -41600.0 -0.66 -0.7935 -0.984 1739696 Maybridge4_003192 O=C1N(Cc2ccccc2)S(=O)(=O)c3ccccc3S(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B03 compound treatment 129920.0 91600.0 1.51 37840.0 -7620.0 -0.12 0.983 0.6482 3064449 Maybridge4_003193 CC(=O)OC[C@H]1O[C@@H](NC(=O)N)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B04 compound treatment 52800.0 14400.0 0.24 21480.0 -24000.0 -0.38 -0.1016 -0.2255 2101805 Maybridge4_003194 CCC(=O)NC(Nc1ccc(O)cc1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B05 compound treatment 138480.0 100000.0 1.65 44560.0 -896.0 -0.01 1.1586 0.701 1443369 Maybridge4_003195 CCc1ccc2oc3nc(N)c(C#N)cc3c(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B06 compound treatment 124560.0 86200.0 1.42 44960.0 -496.0 -0.01 1.0006 0.7032 1585673 Maybridge4_003196 CCOC(=O)CCc1ccc(OCc2ccccc2)c(I)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B07 compound treatment 129360.0 91000.0 1.5 23560.0 -21900.0 -0.35 0.8155 0.5288 3064452 Maybridge4_003197 CC(=O)OC[C@H]1OC[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@H]1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B08 compound treatment 89680.0 51300.0 0.85 13080.0 -32400.0 -0.52 0.2342 0.2361 3178366 Maybridge4_003198 CC1(C)c2ccccc2N3CC(=O)NC31/C=C/c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B09 compound treatment 134960.0 96600.0 1.59 26280.0 -19200.0 -0.31 0.9115 0.5614 1005564 Maybridge4_003199 CC(=O)Nc1ccc(cc1)c2ccc(NC(=O)C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B10 compound treatment 113640.0 75300.0 1.24 37000.0 -8460.0 -0.13 0.7835 0.6267 3178367 Maybridge4_003200 Cc1nn(c(O)c1Cc2c(Cl)cccc2Cl)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B11 compound treatment 24520.0 -13800.0 -0.23 4400.0 -41100.0 -0.65 -0.6242 -0.9006 1167085 Maybridge4_003201 COc1ccc(CC2CCc3ncc(C)cc3C2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B12 compound treatment 138760.0 100000.0 1.66 75720.0 30300.0 0.48 1.5131 0.8765 3178368 Maybridge4_003202 N/N=C(/Cn1nnc(n1)N2CCCCC2)\c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B13 compound treatment 127880.0 89500.0 1.48 58080.0 12600.0 0.2 1.1873 0.796 3064453 Maybridge4_003203 S=c1sc2ccccc2n1CCn3c(=S)sc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B14 compound treatment 49000.0 10600.0 0.18 32880.0 -12600.0 -0.2 -0.0175 -0.0655 1238987 Maybridge4_003204 CCCc1c(C)nc(SCC(=O)C(C)(C)C)nc1OC(=O)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B15 compound treatment 35760.0 -2590.0 -0.04 10960.0 -34500.0 -0.55 -0.4191 -0.7599 3178369 Maybridge4_003205 CC1CN=C(S1)N(CCc2ccccc2)C(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B16 compound treatment 140000.0 102000.0 1.68 28440.0 -17000.0 -0.27 0.9947 0.5852 1004236 Maybridge4_003206 Cc1ccccc1NC(=N)NC(=N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B17 compound treatment 142040.0 104000.0 1.71 29280.0 -16200.0 -0.26 1.028 0.5939 1381247 Maybridge4_003207 Sc1nnc(CCCc2nnc(S)o2)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B18 compound treatment 57920.0 19600.0 0.32 11920.0 -33500.0 -0.53 -0.1496 -0.2395 1184925 Maybridge4_003208 CN(C)C(=O)Oc1nc(SCC(=O)c2ccc(Cl)cc2)nc(C)c1CC(=C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B19 compound treatment 7880.0 -30500.0 -0.5 2040.0 -43400.0 -0.69 -0.845 -0.9877 3064457 Maybridge4_003209 COc1ccccc1C2CCN(CCCOc3ccc(Cl)cc3)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B20 compound treatment 116400.0 78000.0 1.29 36280.0 -9180.0 -0.15 0.8076 0.6228 3178370 Maybridge4_003210 CCNC(=S)NCC1CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B21 compound treatment 110280.0 71900.0 1.19 31200.0 -14300.0 -0.23 0.6789 0.5616 1489027 Maybridge4_003211 Oc1c(Cl)c(=O)n(Cc2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B22 compound treatment 51200.0 12800.0 0.21 20640.0 -24800.0 -0.4 -0.1297 -0.2891 1250091 Maybridge4_003212 O=C(Nc1ccc(cc1)S(=O)(=O)NC2(CC3CC4CC(C3)C2)C4)C5CC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B23 mock treatment 75880.0 37500.0 0.62 44400.0 -1060.0 -0.02 0.4261 0.6876 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 B24 mock treatment 49400.0 11000.0 0.18 59400.0 13900.0 0.22 0.2861 0.9952 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C01 compound treatment 35280.0 -3070.0 -0.05 23840.0 -21600.0 -0.34 -0.2795 -0.8026 3064501 Maybridge4_003213 O=C(Nc1ccccc1)Nc2ccc3nnsc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C02 compound treatment 8640.0 -29700.0 -0.49 2440.0 -43000.0 -0.69 -0.8316 -0.9865 1507422 Maybridge4_003214 CC(C)(C)c1ccc(OCC(=O)n2ncc(C#N)c2N)c(c1)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C03 compound treatment 68920.0 30600.0 0.5 26280.0 -19200.0 -0.31 0.1407 0.2384 1402640 Maybridge4_003215 COc1ccc(OCCN2C(=O)CNC2=S)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C04 compound treatment 69200.0 30800.0 0.51 36600.0 -8860.0 -0.14 0.2602 0.4925 1499674 Maybridge4_003216 Cc1ccc2N(CCCc2c1)C(=O)CC(=O)N3CCCc4cc(C)ccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C05 compound treatment 22640.0 -15700.0 -0.26 7520.0 -37900.0 -0.6 -0.611 -0.9286 3064504 Maybridge4_003217 CC(C)c1ccc(NC(=S)Sc2ccc(F)cc2F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C06 compound treatment 114120.0 75800.0 1.25 25320.0 -20100.0 -0.32 0.6574 0.5092 1213648 Maybridge4_003218 Cc1ccc(CC(=S)N2CCOCC2)cn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C07 compound treatment 41880.0 3530.0 0.06 8200.0 -37300.0 -0.59 -0.3787 -0.6347 3178371 Maybridge4_003219 CCN(C(=O)c1cnccc1C(F)(F)F)c2nc3cc(Cl)ccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C08 compound treatment 95040.0 56700.0 0.94 21160.0 -24300.0 -0.39 0.3878 0.383 1153252 Maybridge4_003220 COc1cc2cc(OCc3c(F)cccc3Cl)nc(C)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C09 compound treatment 166640.0 128000.0 2.12 20720.0 -24700.0 -0.39 1.2186 0.5657 3178372 Maybridge4_003221 CSc1cc(c(cn1)C(=O)Nc2c(C)cccc2C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C10 compound treatment 58840.0 20500.0 0.34 11200.0 -34300.0 -0.55 -0.147 -0.2288 3064507 Maybridge4_003222 CCC/N=c/1\ssc(=O)n1CCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C11 compound treatment 138520.0 100000.0 1.65 35720.0 -9740.0 -0.16 1.0594 0.6379 3178373 Maybridge4_003223 COc1nccc(c1C(=O)NC(=O)Nc2c(C)cccc2C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C12 compound treatment 32840.0 -5510.0 -0.09 12920.0 -32500.0 -0.52 -0.431 -0.8187 3064509 Maybridge4_003224 FC(F)(F)c1ccc(NC(=O)CSCc2cccc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C13 compound treatment 126600.0 88200.0 1.46 90760.0 45300.0 0.72 1.5406 0.9476 1304317 Maybridge4_003225 Clc1cccc(c1)c2noc(=O)n2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C14 compound treatment 100800.0 62400.0 1.03 37200.0 -8260.0 -0.13 0.6358 0.6119 1154699 Maybridge4_003226 CC(C)COC(=O)c1cn(C2CCCCC2)c3ccccc3c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C15 compound treatment 99720.0 61400.0 1.01 26720.0 -18700.0 -0.3 0.5051 0.4783 1407275 Maybridge4_003227 COC(=O)C1c2ccccc2Oc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C16 compound treatment 130520.0 92200.0 1.52 27080.0 -18400.0 -0.29 0.8687 0.5607 1661086 Maybridge4_003228 COc1ccc(CC2C(=O)OC(C)(C)OC2=O)c(Cl)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C17 compound treatment 119160.0 80800.0 1.33 15800.0 -29700.0 -0.47 0.609 0.4303 3178374 Maybridge4_003229 CC1=C(Sc2ccccc2N1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C18 compound treatment 30440.0 -7910.0 -0.13 2600.0 -42900.0 -0.68 -0.5754 -0.8273 3064548 Maybridge4_003230 O=C1/C(=C/c2c[nH]c3ccccc23)/CSc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C19 compound treatment 134600.0 96200.0 1.59 26440.0 -19000.0 -0.3 0.9091 0.5621 3178375 Maybridge4_003231 Cc1cc(Cc2cccs2)c(=O)[nH]n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C20 compound treatment 6920.0 -31400.0 -0.52 2800.0 -42700.0 -0.68 -0.8477 -0.9911 1550561 Maybridge4_003232 OC(COc1ccc(F)cc1)(c2ccc(Cl)cc2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C21 compound treatment 86400.0 48000.0 0.79 28600.0 -16900.0 -0.27 0.3708 0.4429 1029711 Maybridge4_003233 CCOC(=O)c1cc(=O)c2ccc(OCc3ccccc3)cc2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C22 compound treatment 5360.0 -33000.0 -0.54 2680.0 -42800.0 -0.68 -0.8672 -0.9938 3178376 Maybridge4_003234 Oc1ccc(cc1)C2CC(=Nc3ccccc3S2)c4ccccc4O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C23 mock treatment 48840.0 10500.0 0.17 31480.0 -14000.0 -0.22 -0.0351 -0.1245 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 C24 mock treatment 48800.0 10400.0 0.17 64400.0 18900.0 0.3 0.3354 0.9647 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D01 compound treatment 44160.0 5810.0 0.1 33760.0 -11700.0 -0.19 -0.064 -0.3055 1653141 Maybridge4_003235 Nc1cc(=O)[nH]c(=O)n1c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D02 compound treatment 58600.0 20200.0 0.33 44960.0 -496.0 -0.01 0.2307 0.6902 3178377 Maybridge4_003236 CNS(=O)(=O)c1ccc(cc1S(=O)c2ccccc2C(=O)O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D03 compound treatment 57480.0 19100.0 0.32 36160.0 -9300.0 -0.15 0.1185 0.3397 1915933 Maybridge4_003237 COC(=O)Nc1nc2cc(ccc2[nH]1)c3n[nH]c(=O)c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D04 compound treatment 6760.0 -31600.0 -0.52 46680.0 1220.0 0.02 -0.355 -0.6802 1252966 Maybridge4_003238 Oc1c(c2ccccc2)c(=O)[nH]c3ccc(F)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D05 compound treatment 144720.0 106000.0 1.76 68920.0 23500.0 0.37 1.506 0.8389 3178378 Maybridge4_003239 Brc1ccc(cc1)C(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D06 compound treatment 152000.0 114000.0 1.88 71480.0 26000.0 0.41 1.6198 0.8431 3064551 Maybridge4_003240 CCN1C(=O)N(CC)C(=O)C(=Cc2c(O)n(CC)c(=O)n(CC)c2=O)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D07 compound treatment 159600.0 121000.0 2.0 33560.0 -11900.0 -0.19 1.2812 0.6373 3178379 Maybridge4_003241 CC(=O)O[C@@H]1CO[C@@H]([C@@H](OC(=O)C)[C@@H]1OC(=O)C)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D08 compound treatment 80200.0 41800.0 0.69 20000.0 -25500.0 -0.41 0.2015 0.2516 3178380 Maybridge4_003242 CC1(C)c2ccccc2N3CC(=O)NC31/C=C/c4ccc(cc4)N5CCOCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D09 compound treatment 16880.0 -21500.0 -0.35 3760.0 -41700.0 -0.66 -0.7206 -0.9567 1190502 Maybridge4_003243 Clc1ccc2n(CN3CCCCC3)c4ccc(Cl)cc4c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D10 compound treatment 138920.0 101000.0 1.66 20360.0 -25100.0 -0.4 0.891 0.5218 3064581 Maybridge4_003244 CNC(=S)Nc1cc(Cl)cc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D11 compound treatment 86160.0 47800.0 0.79 30360.0 -15100.0 -0.24 0.3879 0.4701 1208488 Maybridge4_003245 OC(=O)CCC1CCCCCCCCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D12 compound treatment 152040.0 114000.0 1.88 104640.0 59200.0 0.94 1.994 0.9494 3064582 Maybridge4_003246 O/N=C(/Cn1nnc(n1)N2CCCC2)\c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D13 compound treatment 148800.0 110000.0 1.82 111080.0 65600.0 1.05 2.0288 0.9652 3064584 Maybridge4_003247 C([n+]1ccccc1)[n+]2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D14 compound treatment 86560.0 48200.0 0.8 20160.0 -25300.0 -0.4 0.2776 0.3112 3178381 Maybridge4_003248 Cc1nc(SCC(=O)C(C)(C)C)nc(O)c1Cc2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D15 compound treatment 61680.0 23300.0 0.39 14280.0 -31200.0 -0.5 -0.0791 -0.1258 3178382 Maybridge4_003249 CC(N(C(=O)Nc1ccc(Cl)cc1)C2=NCC(C)S2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D16 compound treatment 101880.0 63500.0 1.05 34760.0 -10700.0 -0.17 0.621 0.5845 3064586 Maybridge4_003250 CC(C)(C)c1cs/c(=N\c2ccc(F)cc2F)/o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D17 compound treatment 86200.0 47800.0 0.79 23160.0 -22300.0 -0.36 0.3072 0.3547 3178383 Maybridge4_003251 C(CCc1nnc(SCc2ccccc2)o1)Cc3nnc(SCc4ccccc4)o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D18 compound treatment 22600.0 -15800.0 -0.26 10160.0 -35300.0 -0.56 -0.5817 -0.9385 3064589 Maybridge4_003252 FC(F)(F)c1ccc(Cl)c(Nc2ncnc(n2)n3cccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D19 compound treatment 135480.0 97100.0 1.6 55080.0 9620.0 0.15 1.2422 0.7712 1521138 Maybridge4_003253 COc1ccc(CCNC(=O)C2CCCCC2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D20 compound treatment 110520.0 72200.0 1.19 38880.0 -6580.0 -0.1 0.7682 0.6424 2078178 Maybridge4_003254 CC(C)[n+]1c(C)csc1Nc2ccc(F)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D21 compound treatment 77080.0 38700.0 0.64 38200.0 -7260.0 -0.12 0.3702 0.5699 1308049 Maybridge4_003255 O=c1cc(NCc2ccccc2)[nH]nc1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D22 compound treatment 37600.0 -754.0 -0.01 21600.0 -23900.0 -0.38 -0.2777 -0.7299 3178478 Maybridge4_003256 CCCC1=NNC(=O)C1Cc2c(Cl)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D23 mock treatment 58960.0 20600.0 0.34 2560.0 -42900.0 -0.68 -0.2429 -0.3181 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 D24 mock treatment 39360.0 1010.0 0.02 29280.0 -16200.0 -0.26 -0.1706 -0.6602 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E01 compound treatment 10080.0 -28300.0 -0.47 6080.0 -39400.0 -0.63 -0.7738 -0.9894 3064592 Maybridge4_003257 CSC1=NCC(=O)N1Cc2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E02 compound treatment 44440.0 6090.0 0.1 31080.0 -14400.0 -0.23 -0.091 -0.3636 1522772 Maybridge4_003258 CCCCc1cc(C)c2ncc(C(=O)O)c(O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E03 compound treatment 42720.0 4370.0 0.07 23360.0 -22100.0 -0.35 -0.1981 -0.551 1340715 Maybridge4_003259 CC(C)NC(=O)N(Cc1cccs1)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E04 compound treatment 45200.0 6850.0 0.11 33400.0 -12100.0 -0.19 -0.056 -0.251 1280280 Maybridge4_003260 Oc1c(c2ccccc2)c(=O)n3c4ccccc4c5cccc1c53 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E05 compound treatment 111360.0 73000.0 1.21 87360.0 41900.0 0.67 1.3244 0.9612 3178479 Maybridge4_003261 COC(=O)c1ccccc1S(=O)(=O)NC(=O)Nc2nc(C)c3CS(=O)(=O)CCc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E06 compound treatment 128520.0 90200.0 1.49 56640.0 11200.0 0.18 1.1785 0.7862 1428973 Maybridge4_003262 COC(=O)C1=C(C)NC(=O)CC1c2ccccc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E07 compound treatment 118920.0 80600.0 1.33 55000.0 9540.0 0.15 1.048 0.7829 3178480 Maybridge4_003263 CSc1nc(nc(N)c1C#N)c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E08 compound treatment 124600.0 86200.0 1.42 37560.0 -7900.0 -0.13 0.9177 0.6421 1476870 Maybridge4_003264 COc1ccc2n(C3CC3)c(C)c(C(=O)ON4C(=O)CCC4=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E09 compound treatment 99520.0 61200.0 1.01 26200.0 -19300.0 -0.31 0.4969 0.4709 3178481 Maybridge4_003265 Cc1cccc(C)c1NC(=O)c2cnc(NC3CCCCC3)cc2C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E10 compound treatment 130200.0 91800.0 1.52 37000.0 -8460.0 -0.13 0.9768 0.6417 3063905 Maybridge4_003266 FC(F)(F)c1cc(Cl)c2ncc(nc2c1)c3ccc(Br)s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E11 compound treatment 142240.0 104000.0 1.71 65000.0 19500.0 0.31 1.4329 0.8221 3178482 Maybridge4_003267 FC(F)(F)c1ccc(nc1)S(=O)(=O)/C(=C/c2ccsc2)/C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E12 compound treatment 120600.0 82200.0 1.36 87600.0 42100.0 0.67 1.435 0.9473 1329285 Maybridge4_003268 CC(C)C1CCC(C)CC1NCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E13 compound treatment 150800.0 112000.0 1.86 136840.0 91400.0 1.46 2.3424 0.9928 3063910 Maybridge4_003269 COc1ccccc1c2nn(c3cccc(n3)C(F)(F)F)c(=O)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E14 compound treatment 145760.0 107000.0 1.77 61720.0 16300.0 0.26 1.437 0.802 1482860 Maybridge4_003270 COc1ccc(Oc2ncccc2NC(=O)c3ccc(OC)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E15 compound treatment 56880.0 18500.0 0.31 22880.0 -22600.0 -0.36 -0.0382 -0.0809 1317058 Maybridge4_003271 COc1ccc(CNc2nc(c3cccs3)c(C#N)c(=O)n2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E16 compound treatment 119560.0 81200.0 1.34 56960.0 11500.0 0.18 1.0775 0.7964 3063941 Maybridge4_003272 Cc1n[nH]c(=S)n1/N=C\c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E17 compound treatment 79000.0 40600.0 0.67 35360.0 -10100.0 -0.16 0.3607 0.5227 1597311 Maybridge4_003273 CCOC(CNc1ccc2nnc(c3ccccc3)n2n1)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E18 compound treatment 8880.0 -29500.0 -0.49 4280.0 -41200.0 -0.66 -0.8081 -0.9891 3063945 Maybridge4_003274 O=C1/C(=C\c2c[nH]c3ccccc23)/C(Oc4ccccc14)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E19 compound treatment 118360.0 80000.0 1.32 53720.0 8260.0 0.13 1.027 0.7738 3178483 Maybridge4_003275 Cc1cc(Cc2ccc(cc2)C(F)(F)F)c(=O)[nH]n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E20 compound treatment 84120.0 45800.0 0.76 45200.0 -256.0 0.0 0.5313 0.7033 1460994 Maybridge4_003276 CN(C)CCC(O)(CCc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E21 compound treatment 6040.0 -32300.0 -0.53 3280.0 -42200.0 -0.67 -0.8525 -0.9934 3063949 Maybridge4_003277 CN(C)/C=N/c1nnc(Sc2ccnc3cc(Cl)ccc23)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E22 compound treatment 52960.0 14600.0 0.24 22960.0 -22500.0 -0.36 -0.083 -0.1922 1708827 Maybridge4_003278 CCOC(=O)COc1ccc(cc1)C2=Nc3ccccc3NC(C2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E23 mock treatment 41480.0 3130.0 0.05 42520.0 -2940.0 -0.05 0.0034 0.0488 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 E24 mock treatment 30120.0 -8230.0 -0.14 30840.0 -14600.0 -0.23 -0.2608 -0.9671 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F01 compound treatment 69800.0 31400.0 0.52 23920.0 -21500.0 -0.34 0.1243 0.1998 3063951 Maybridge4_003279 Brc1ccc(cc1)C(=O)C2C(=O)OC(=CC2=O)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F02 compound treatment 37920.0 -434.0 -0.01 27440.0 -18000.0 -0.29 -0.2081 -0.7245 1535413 Maybridge4_003280 CN1CCN(CCN2C(=O)c3ccccc3Sc4cc(Cl)ccc4S2(=O)=O)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F03 compound treatment 47800.0 9450.0 0.16 25480.0 -20000.0 -0.32 -0.1149 -0.324 1134402 Maybridge4_003281 O=S(=O)(N(CCC#N)C1CCCCC1)c2cccc3nsnc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F04 compound treatment 6200.0 -32200.0 -0.53 4120.0 -41300.0 -0.66 -0.8412 -0.9943 3178484 Maybridge4_003282 Cc1ccccc1/C=C/c2c[nH]c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F05 compound treatment 96400.0 58000.0 0.96 63360.0 17900.0 0.29 0.8793 0.8795 3063955 Maybridge4_003283 OC(=O)c1ccc(cc1C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F06 compound treatment 142640.0 104000.0 1.72 97720.0 52300.0 0.83 1.8063 0.9445 1062519 Maybridge4_003284 O=C(C1CCCCC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F07 compound treatment 116800.0 78400.0 1.29 58640.0 13200.0 0.21 1.0642 0.8112 3178485 Maybridge4_003285 O=C(OC[C@H]1O[C@@H](C#N)[C@H](OC(=O)c2ccccc2)[C@@H]1OC(=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F08 compound treatment 10320.0 -28000.0 -0.46 5320.0 -40100.0 -0.64 -0.7796 -0.9874 1658235 Maybridge4_003286 CC1(C)c2ccccc2N(CCC(=O)N)C31Oc4ccc5ccccc5c4C=C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F09 compound treatment 10440.0 -27900.0 -0.46 6200.0 -39300.0 -0.63 -0.7682 -0.9887 1416171 Maybridge4_003287 OC(CN1CCNCC1)Cn2c3ccc(Br)cc3c4cc(Br)ccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F10 compound treatment 133240.0 94900.0 1.57 112360.0 66900.0 1.07 1.8616 0.9824 1438412 Maybridge4_003288 O=C(Cn1nnc(n1)N2CCOCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F11 compound treatment 130840.0 92500.0 1.53 78200.0 32700.0 0.52 1.4486 0.8978 3178486 Maybridge4_003289 COc1cc(COC(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)O)cc(OC)c1.C1CCC(CC1)NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F12 compound treatment 156800.0 118000.0 1.96 126480.0 81000.0 1.29 2.2957 0.9797 1614817 Maybridge4_003290 COc1ccc(CCNC(=S)NC2CC2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F13 compound treatment 33080.0 -5270.0 -0.09 26720.0 -18700.0 -0.3 -0.2727 -0.8767 3178487 Maybridge4_003291 CCN1/C(=C\C(=S)Nc2ccccc2)/Sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F14 compound treatment 130800.0 92400.0 1.53 89880.0 44400.0 0.71 1.5797 0.939 1593331 Maybridge4_003292 CC(C)(C)C(=O)Cn1nnc(n1)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F15 compound treatment 59920.0 21600.0 0.36 51920.0 6460.0 0.1 0.3246 0.8758 3063998 Maybridge4_003293 CC1=[N+](C)c2cc(ccc2C1(C)C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F16 compound treatment 23320.0 -15000.0 -0.25 32880.0 -12600.0 -0.2 -0.3172 -0.9944 3178488 Maybridge4_003294 Fc1ccc(NC(=S)Nc2cc(ccc2N3CCCC3)C(F)(F)F)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F17 compound treatment 125480.0 87100.0 1.44 73200.0 27700.0 0.44 1.3296 0.8837 1142281 Maybridge4_003295 CN1C(=C(C(NC1=O)c2ccccc2)C(=O)OCc3ccccc3)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F18 compound treatment 120520.0 82200.0 1.36 90600.0 45100.0 0.72 1.4679 0.956 1704243 Maybridge4_003296 COCc1cc(O)n2nc(Nc3cc(Cl)ccc3C)nc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F19 compound treatment 120240.0 81900.0 1.35 79640.0 34200.0 0.54 1.3411 0.9202 1313602 Maybridge4_003297 O=c1cc(NCc2ccccc2)n(c3ccccc3)c(=O)n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F20 compound treatment 84800.0 46400.0 0.77 66160.0 20700.0 0.33 0.7755 0.929 1473392 Maybridge4_003298 CCN(CC)C(=O)Sc1nc2ccccc2c(=O)n1CC3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F21 compound treatment 78960.0 40600.0 0.67 57240.0 11800.0 0.19 0.6068 0.8717 1547311 Maybridge4_003299 OC(=O)C1(C2C3C14)C5C2CCC3C45C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F22 compound treatment 44600.0 6250.0 0.1 39640.0 -5820.0 -0.09 0.0074 0.0531 3064002 Maybridge4_003300 CCCc1cc(=O)oc2cc(OC(=O)/C=C/c3cccs3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F23 mock treatment 39720.0 1370.0 0.02 38080.0 -7380.0 -0.12 -0.0672 -0.5612 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 F24 mock treatment 54920.0 16600.0 0.27 26320.0 -19100.0 -0.31 -0.0223 -0.0544 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G01 compound treatment 20440.0 -17900.0 -0.3 19680.0 -25800.0 -0.41 -0.4996 -0.987 1507436 Maybridge4_003301 Cc1cc(no1)N(Cc2cccc(Cl)c2Cl)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G02 compound treatment 38880.0 526.0 0.01 28360.0 -17100.0 -0.27 -0.1865 -0.6842 1593004 Maybridge4_003302 O=c1ccc(n[nH]1)c2ccncc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G03 compound treatment 44560.0 6210.0 0.1 31640.0 -13800.0 -0.22 -0.0833 -0.3429 3178489 Maybridge4_003303 CSC1=N/C(=C\c2ccccc2Cl)/C(=O)N1N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G04 compound treatment 47000.0 8650.0 0.14 42040.0 -3420.0 -0.05 0.0624 0.4086 3178490 Maybridge4_003304 COc1ccc(C/N=C(\C)/c2c(O)c3ccccc3n(C)c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G05 compound treatment 99080.0 60700.0 1.0 77640.0 32200.0 0.51 1.0715 0.9516 3064042 Maybridge4_003305 CCN(C(=O)c1cnccc1C(F)(F)F)c2ccc(Cl)cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G06 compound treatment 47520.0 9170.0 0.15 43800.0 -1660.0 -0.03 0.0883 0.5751 1261792 Maybridge4_003306 Cc1ccc(Oc2ncccc2NC(=O)C(=S)NCc3ccccc3)c4CCCc41 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G07 compound treatment 109280.0 70900.0 1.17 90880.0 45400.0 0.72 1.3398 0.9733 3064045 Maybridge4_003307 Cc1nc(c2nnc(o2)c3ccccc3)c(o1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G08 compound treatment 111600.0 73200.0 1.21 80120.0 34700.0 0.55 1.2456 0.937 3178491 Maybridge4_003308 COc1ccc(cc1OC2CCCC2)C3CC(=O)NN3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G09 compound treatment 113520.0 75200.0 1.24 82560.0 37100.0 0.59 1.2955 0.9425 3064046 Maybridge4_003309 CNC(=O)NC(=O)c1cnccc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G10 compound treatment 115680.0 77300.0 1.28 80840.0 35400.0 0.56 1.3014 0.9326 1193128 Maybridge4_003310 Cc1c(OCc2ccc(Cl)cc2Cl)ccc3C(=O)CC(C)(C)Oc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G11 compound treatment 9640.0 -28700.0 -0.47 8040.0 -37400.0 -0.6 -0.7568 -0.9935 3064048 Maybridge4_003311 COC(=O)c1cnc(Oc2c(Cl)cc(N)cc2Cl)cc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G12 compound treatment 42320.0 3970.0 0.07 41040.0 -4420.0 -0.07 -0.0035 -0.0362 1126959 Maybridge4_003312 COc1ccccc1C2CCN(CC2)C(=O)CSCc3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G13 compound treatment 81280.0 42900.0 0.71 88360.0 42900.0 0.68 0.9846 0.9998 3064052 Maybridge4_003313 COc1cccc(OC)c1CN(C)C(=O)c2cnc(Oc3ccccc3)cc2C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G14 compound treatment 11200.0 -27200.0 -0.45 16720.0 -28700.0 -0.46 -0.6408 -0.9999 1245694 Maybridge4_003314 NNC(=O)Cn1c2ccccc2c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G15 compound treatment 98560.0 60200.0 0.99 100600.0 55100.0 0.88 1.3242 0.9981 3064053 Maybridge4_003315 CC1CC(=O)NN=C1c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G16 compound treatment 91480.0 53100.0 0.88 82880.0 37400.0 0.6 1.0419 0.9824 3178582 Maybridge4_003316 COc1cc(/C=N\n2cn[nH]c2=S)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G17 compound treatment 80400.0 42000.0 0.69 68800.0 23300.0 0.37 0.7539 0.9573 1565631 Maybridge4_003317 CSc1nc2cccc(F)c2c(=O)n1c3ccc(C)c(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G18 compound treatment 87920.0 49600.0 0.82 48880.0 3420.0 0.05 0.6171 0.7526 1496711 Maybridge4_003318 Cc1ccccc1NC(=O)COc2ccc3C(=O)CC(C)(C)Oc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G19 compound treatment 99160.0 60800.0 1.0 94600.0 49100.0 0.78 1.2636 0.9925 3178583 Maybridge4_003319 CCc1nc(S)[nH]c(=O)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G20 compound treatment 65920.0 27600.0 0.46 60000.0 14500.0 0.23 0.4857 0.951 1520911 Maybridge4_003320 O=C1CC(Sc2ccccc2N1)c3coc4ccccc4c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G21 compound treatment 82320.0 44000.0 0.73 63840.0 18400.0 0.29 0.7204 0.9204 1387364 Maybridge4_003321 CC(=O)N1CCc2cc(NC(=S)Nc3ccccc3Cl)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G22 compound treatment 20280.0 -18100.0 -0.3 15440.0 -30000.0 -0.48 -0.5493 -0.9742 1175310 Maybridge4_003322 O=C(COc1ccc(cc1)C2=Nc3ccccc3NC(C2)c4ccccc4)Nc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G23 mock treatment 42520.0 4170.0 0.07 34120.0 -11300.0 -0.18 -0.0791 -0.4093 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 G24 mock treatment 24840.0 -13500.0 -0.22 20760.0 -24700.0 -0.39 -0.4361 -0.9638 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H01 compound treatment 25360.0 -13000.0 -0.21 37520.0 -7940.0 -0.13 -0.2411 -0.9683 3064847 Maybridge4_003323 N=C(NC(=S)Nc1ccccc1)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H02 compound treatment 36920.0 -1430.0 -0.02 34680.0 -10800.0 -0.17 -0.1382 -0.797 1265943 Maybridge4_003324 Oc1cc(c2ccc(F)cc2)n(c3ccccc3)c(=O)c1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H03 compound treatment 24160.0 -14200.0 -0.23 13120.0 -32300.0 -0.52 -0.5301 -0.9363 1493327 Maybridge4_003325 CC(C)c1c(Br)c(=O)oc2c3CCCN4CCCc(cc12)c43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H04 compound treatment 80720.0 42400.0 0.7 53760.0 8300.0 0.13 0.5881 0.8263 1020946 Maybridge4_003326 NC(=O)NCCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H05 compound treatment 108200.0 69800.0 1.15 94640.0 49200.0 0.78 1.3696 0.9823 3064848 Maybridge4_003327 C/C(=N/O)/CC(c1ccccc1)c2c(O)c3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H06 compound treatment 118120.0 79800.0 1.32 103400.0 57900.0 0.92 1.5841 0.9849 1378346 Maybridge4_003328 Cn1c(=O)n(C)c2ncn(CC(O)COc3ccccc3)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H07 compound treatment 101280.0 62900.0 1.04 97520.0 52100.0 0.83 1.3213 0.9938 3064849 Maybridge4_003329 CO[C@@H]1O[C@H](COC(=O)c2ccccc2)[C@H](OC(=O)c3ccccc3)[C@H]1OC(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H08 compound treatment 53880.0 15500.0 0.26 67520.0 22100.0 0.35 0.4299 0.9879 1554777 Maybridge4_003330 CCn1c2C(=O)CCCc2c3cc(OCc4ccccc4)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H09 compound treatment 117600.0 79200.0 1.31 115000.0 69500.0 1.11 1.7088 0.9966 3064850 Maybridge4_003331 OC1=C(C(=O)c2ccccc12)c3ccc(I)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H10 compound treatment 107760.0 69400.0 1.15 132440.0 87000.0 1.39 1.7905 0.9955 3178584 Maybridge4_003332 FC(F)(F)c1cccc(c1)n2c(S)nnc2Cn3nnc(n3)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H11 compound treatment 8920.0 -29400.0 -0.49 9600.0 -35900.0 -0.57 -0.7477 -0.9967 1668484 Maybridge4_003333 Fc1ccc(cc1)N(C(=O)C2(CC3CC4CC(C3)C2)C4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H12 compound treatment 149640.0 111000.0 1.84 143040.0 97600.0 1.56 2.3988 0.9966 3064851 Maybridge4_003334 COc1ccc(CCN/2C(=O)CS\C2=N/C3CC3)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H13 compound treatment 116280.0 77900.0 1.29 112000.0 66500.0 1.06 1.6595 0.9954 1561039 Maybridge4_003335 O=c1[nH]c2ccccc2c(=O)n1CCSc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H14 compound treatment 10360.0 -28000.0 -0.46 9800.0 -35700.0 -0.57 -0.7286 -0.9947 3064852 Maybridge4_003336 CC/N=C(/Nc1ccc(cc1)C(C)(C)C)\SCC2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H15 compound treatment 13440.0 -24900.0 -0.41 17960.0 -27500.0 -0.44 -0.6007 -0.9995 1155855 Maybridge4_003337 Oc1c(O)c(CN2CCCCC2)c3ccccc3c1CN4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H16 compound treatment 81480.0 43100.0 0.71 97600.0 52100.0 0.83 1.0911 0.997 3064853 Maybridge4_003338 COC(=O)c1cccc(NC(=N)NC(=N)N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H17 compound treatment 88160.0 49800.0 0.82 102680.0 57200.0 0.91 1.2263 0.9987 3178585 Maybridge4_003339 Clc1ccc(cc1)S(=O)(=O)C2=CC34CCCC4(C2)C=C(C3)S(=O)(=O)c5ccc(Cl)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H18 compound treatment 108280.0 69900.0 1.15 109120.0 63700.0 1.01 1.5337 0.9979 3064854 Maybridge4_003340 CC(=C)CC1C(=NNC1=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H19 compound treatment 118440.0 80100.0 1.32 101520.0 56100.0 0.89 1.5666 0.9818 3178586 Maybridge4_003341 CC1(C)O[C@@H]2[C@@H](CO)O[C@H]([C@@H]2O1)n3cnc4c(N)ncnc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H20 compound treatment 35800.0 -2550.0 -0.04 57280.0 11800.0 0.19 0.1034 0.5357 3064855 Maybridge4_003342 Clc1ccc(NC(=S)NCC2CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H21 compound treatment 41840.0 3490.0 0.06 35440.0 -10000.0 -0.16 -0.0722 -0.4254 1331091 Maybridge4_003343 CN(C)CCNc1cc(nc2ccccc12)c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H22 compound treatment 3600.0 -34800.0 -0.57 3760.0 -41700.0 -0.66 -0.8756 -0.9973 1734961 Maybridge4_003344 CCCc1c(Cc2c(F)cccc2Cl)c(=O)oc3cc(O)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H23 mock treatment 55200.0 16800.0 0.28 38160.0 -7300.0 -0.12 0.1144 0.3796 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 H24 mock treatment 26200.0 -12200.0 -0.2 23040.0 -22400.0 -0.36 -0.3945 -0.9628 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I01 compound treatment 29720.0 -8630.0 -0.14 41120.0 -4340.0 -0.07 -0.1496 -0.9448 3178587 Maybridge4_003345 CC(C)(C)C(=O)OCc1nc(cs1)c2ccc(cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I02 compound treatment 37920.0 -434.0 -0.01 33320.0 -12100.0 -0.19 -0.1418 -0.7328 1626253 Maybridge4_003346 CSc1c(C#N)c(N)nc2sc(C(=O)c3ccc(Cl)c(Cl)c3)c(N)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I03 compound treatment 48600.0 10200.0 0.17 38520.0 -6940.0 -0.11 0.0414 0.205 1244996 Maybridge4_003347 CCNC(=O)N(Cc1ccccc1)Cc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I04 compound treatment 84640.0 46300.0 0.76 81440.0 36000.0 0.57 0.9458 0.99 1073759 Maybridge4_003348 CSc1ncc(Br)c(n1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I05 compound treatment 108360.0 70000.0 1.16 88280.0 42800.0 0.68 1.2998 0.9684 3178588 Maybridge4_003349 CC(C)(C)NC(=O)Nc1cnccc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I06 compound treatment 84200.0 45800.0 0.76 125000.0 79500.0 1.27 1.4316 0.9696 3064856 Maybridge4_003350 CCOC(=O)CC1=Nn2c(nnc2SC1)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I07 compound treatment 101000.0 62600.0 1.03 120600.0 75100.0 1.2 1.5781 0.9973 3178589 Maybridge4_003351 Cc1nc(C(=O)NCC(=O)c2ccc(Cl)cc2)c(o1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I08 compound treatment 77400.0 39000.0 0.64 113040.0 67600.0 1.08 1.2174 0.9698 1403866 Maybridge4_003352 O=c1cc([nH]c(=O)[nH]1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I09 compound treatment 68040.0 29700.0 0.49 100320.0 54900.0 0.87 0.9648 0.9625 3178590 Maybridge4_003353 COc1ccc(CN(C)C(=O)c2cnc(OC)cc2C(F)(F)F)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I10 compound treatment 7560.0 -30800.0 -0.51 8880.0 -36600.0 -0.58 -0.7717 -0.9977 1529338 Maybridge4_003354 CCCCc1ccc(NC(=O)CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I11 compound treatment 116000.0 77600.0 1.28 108600.0 63100.0 1.01 1.618 0.9928 3064857 Maybridge4_003355 CN(C(=O)c1cn(C)c(=O)cc1C(F)(F)F)c2ccc(Cl)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I12 compound treatment 150000.0 112000.0 1.84 138640.0 93200.0 1.49 2.3534 0.9943 1141964 Maybridge4_003356 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3cccc4nonc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I13 compound treatment 121520.0 83200.0 1.37 127240.0 81800.0 1.3 1.8925 0.9997 3064858 Maybridge4_003357 CSc1nc(Nc2cccc(c2)C(F)(F)F)cc(c1C#N)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I14 compound treatment 59800.0 21400.0 0.35 84400.0 38900.0 0.62 0.6892 0.9645 1260487 Maybridge4_003358 Cc1ccc(Sc2ncccc2NC(=O)c3cccc4ccccc34)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I15 compound treatment 39920.0 1570.0 0.03 50480.0 5020.0 0.08 0.0749 0.8902 1269491 Maybridge4_003359 CCOC(=O)c1cnn2c1nc(Sc3cccc(OC)c3)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I16 compound treatment 68800.0 30400.0 0.5 97880.0 52400.0 0.84 0.9462 0.9704 1008109 Maybridge4_003360 S=C(Nc1ccccn1)Nc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I17 compound treatment 80280.0 41900.0 0.69 91360.0 45900.0 0.73 1.0067 0.9996 3064859 Maybridge4_003361 O/N=C/Nc1ccc2nnc(c3ccccc3)n2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I18 compound treatment 75120.0 36800.0 0.61 81280.0 35800.0 0.57 0.8329 0.9995 1290576 Maybridge4_003362 Oc1ccc2c(=O)c(coc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I19 compound treatment 75280.0 36900.0 0.61 135000.0 89500.0 1.43 1.4402 0.928 3064860 Maybridge4_003363 Cc1ccc(Cc2cc(C)n[nH]c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I20 compound treatment 64400.0 26000.0 0.43 71440.0 26000.0 0.41 0.5969 0.9998 1499068 Maybridge4_003364 CC(=O)NC1C(c2ccccc2)S(=O)(=O)c3ccccc3NC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I21 compound treatment 46200.0 7850.0 0.13 52080.0 6620.0 0.11 0.1662 0.9949 1721722 Maybridge4_003365 CC(=O)N1CCc2cc(NC(=S)NCc3cccs3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I22 compound treatment 37240.0 -1110.0 -0.02 36320.0 -9140.0 -0.15 -0.116 -0.7901 1210152 Maybridge4_003366 CCC(=O)N1C(CC(=Nc2ccccc12)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I23 mock treatment 33960.0 -4390.0 -0.07 36560.0 -8900.0 -0.14 -0.1515 -0.9515 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 I24 mock treatment 19000.0 -19400.0 -0.32 35360.0 -10100.0 -0.16 -0.3397 -0.9496 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J01 compound treatment 18720.0 -19600.0 -0.32 50360.0 4900.0 0.08 -0.1739 -0.5216 1243119 Maybridge4_003367 Cc1c(O)c(c2ccccc2)c(=O)n(c3ccccn3)c1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J02 compound treatment 2760.0 -35600.0 -0.59 3680.0 -41800.0 -0.67 -0.8863 -0.9981 1140611 Maybridge4_003368 CCCCc1c(O)cc(c2ccccc2)n(Cc3ccccc3)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J03 compound treatment 45440.0 7090.0 0.12 59760.0 14300.0 0.23 0.2439 0.9519 3178591 Maybridge4_003369 Cc1ccc(cc1)C(=O)/C=C\2/NCCNC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J04 compound treatment 56400.0 18000.0 0.3 74840.0 29400.0 0.47 0.5418 0.9761 3178682 Maybridge4_003370 CC(=O)O[C@H]1[C@H](O[C@@H]2OC(C)(C)O[C@H]12)C(O)CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J05 compound treatment 39920.0 1570.0 0.03 67720.0 22300.0 0.35 0.2692 0.7566 1447328 Maybridge4_003371 CC(C)(C)C(=O)CC(Nc1ccccc1)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J06 compound treatment 34240.0 -4110.0 -0.07 42240.0 -3220.0 -0.05 -0.0843 -0.9904 1256088 Maybridge4_003372 C=CCC1(CCCCC1)NCCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J07 compound treatment 51040.0 12700.0 0.21 100320.0 54900.0 0.87 0.7664 0.8523 1171716 Maybridge4_003373 CN1CCCC(C1)OC(=O)C2=C(C)NC3(O)c4ccccc4C(=O)C23O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J08 compound treatment 35960.0 -2390.0 -0.04 116320.0 70900.0 1.13 0.7707 0.682 1583880 Maybridge4_003374 CC(C)(C)Oc1ccc(CC(CO)NC(=O)OCC2c3ccccc3-c4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J09 compound treatment 25960.0 -12400.0 -0.2 41760.0 -3700.0 -0.06 -0.1863 -0.8752 1604468 Maybridge4_003375 COc1ccccc1C2CCN(CC2)S(=O)(=O)c3ccccc3Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J10 compound treatment 10360.0 -28000.0 -0.46 32800.0 -12700.0 -0.2 -0.4694 -0.9309 3064861 Maybridge4_003376 Cc1cc(OC(=O)c2ccco2)nc(SCc3c(Cl)cccc3Cl)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J11 compound treatment 110720.0 72400.0 1.19 146040.0 101000.0 1.6 1.9783 0.9895 3178683 Maybridge4_003377 CC(C)C1(C)N2C(=O)c3ccccc3C2=NC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J12 compound treatment 117240.0 78900.0 1.3 138040.0 92600.0 1.48 1.9642 0.9981 3064862 Maybridge4_003378 O=C1CS/C(=N\C2CC2)/N1Cc3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J13 compound treatment 117520.0 79200.0 1.31 137720.0 92300.0 1.47 1.9639 0.9983 1167872 Maybridge4_003379 OC(=O)CNC(=O)CSc1ccccn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J14 compound treatment 92880.0 54500.0 0.9 140280.0 94800.0 1.51 1.7051 0.9693 1457281 Maybridge4_003380 COCc1cc(OC(=O)N(C)C)nc(n1)c2ccncc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J15 compound treatment 71640.0 33300.0 0.55 122440.0 77000.0 1.23 1.2562 0.9343 3178684 Maybridge4_003381 CN(C)/C=N/n1cnc2sc3CCCCc3c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J16 compound treatment 69840.0 31500.0 0.52 98800.0 53300.0 0.85 0.9687 0.9721 3178685 Maybridge4_003382 NC(=N)NC(=N)Nc1cc(n[nH]1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J17 compound treatment 71080.0 32700.0 0.54 116560.0 71100.0 1.13 1.1833 0.9426 1294257 Maybridge4_003383 COc1cc(Cc2cc(OC)c(C)cc2OC)c(OC)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J18 compound treatment 78240.0 39900.0 0.66 112080.0 66600.0 1.06 1.2164 0.9736 3178686 Maybridge4_003384 CCCCc1c(C)nc(nc1O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J19 compound treatment 53920.0 15600.0 0.26 75960.0 30500.0 0.49 0.5255 0.9556 3176922 Maybridge4_003385 OC[C@H]1O[C@H](C[C@@H]1O)n2cc(Br)c(=O)[nH]c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J20 compound treatment 44800.0 6450.0 0.11 55400.0 9940.0 0.16 0.1873 0.9812 3064863 Maybridge4_003386 COc1cc(/C=N/c2ccc(Cl)cc2)ccc1OC(=O)/C=C/c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J21 compound treatment 33880.0 -4470.0 -0.07 49840.0 4380.0 0.07 -0.0028 -0.0277 1169652 Maybridge4_003387 C1CN(CCO1)c2c3CCc4ccccc4-c3nc5ccccc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J22 compound treatment 3400.0 -35000.0 -0.58 4720.0 -40700.0 -0.65 -0.8671 -0.9983 1608425 Maybridge4_003388 CCCC1=NN(C(=O)C(C)(C)C)C(=O)C1Cc2c(F)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J23 mock treatment 52240.0 13900.0 0.23 62080.0 16600.0 0.26 0.3494 0.9974 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 J24 mock treatment 26400.0 -12000.0 -0.2 36640.0 -8820.0 -0.14 -0.2389 -0.9862 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K01 compound treatment 3200.0 -35200.0 -0.58 4600.0 -40900.0 -0.65 -0.8708 -0.9983 3064864 Maybridge4_003389 CSC1=N/C(=C\c2ccccc2O)/C(=O)N1Cc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K02 compound treatment 10760.0 -27600.0 -0.46 16440.0 -29000.0 -0.46 -0.6491 -1.0 1422721 Maybridge4_003390 CCOC(=O)c1cnn(C(=O)COc2ccc(C)c3CCCc32)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K03 compound treatment 16720.0 -21600.0 -0.36 16440.0 -29000.0 -0.46 -0.5795 -0.9918 3178687 Maybridge4_003391 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1CCc3c[nH]c4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K04 compound treatment 53440.0 15100.0 0.25 56640.0 11200.0 0.18 0.3021 0.9866 1502240 Maybridge4_003392 COC(=O)c1[nH]c(C(=O)OC)c(O)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K05 compound treatment 53920.0 15600.0 0.26 96760.0 51300.0 0.82 0.7599 0.8866 3064865 Maybridge4_003393 COc1cccc(NC(=O)c2cnccc2C(F)(F)F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K06 compound treatment 67560.0 29200.0 0.48 102480.0 57000.0 0.91 0.9836 0.956 3178688 Maybridge4_003394 CCOC(=O)/C=C(\C)/Nc1cccc(N\C(=C\C(=O)OCC)\C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K07 compound treatment 68240.0 29900.0 0.49 141360.0 95900.0 1.53 1.4297 0.8901 3064866 Maybridge4_003395 FC(F)(F)c1ccc(cc1)c2nc(NC(=O)Nc3ccccc3)cs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K08 compound treatment 4960.0 -33400.0 -0.55 18480.0 -27000.0 -0.43 -0.6938 -0.9924 1570272 Maybridge4_003396 CCC1N(CCc2c1[nH]c3ccccc23)C(=O)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K09 compound treatment 49800.0 11400.0 0.19 93640.0 48200.0 0.77 0.6766 0.8556 3064867 Maybridge4_003397 FC(F)(F)c1ccncc1C(=O)NC(=O)Nc2ccc(Cl)cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K10 compound treatment 44400.0 6050.0 0.1 84400.0 38900.0 0.62 0.5095 0.8104 1687043 Maybridge4_003398 Cc1cc(C)c(COc2ccc3C(=O)CC(C)(C)Oc3c2C)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K11 compound treatment 67720.0 29400.0 0.48 123920.0 78500.0 1.25 1.2271 0.9149 3064868 Maybridge4_003399 FC(F)(F)c1ccc(nc1)n2nc(oc2=O)c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K12 compound treatment 27400.0 -11000.0 -0.18 48840.0 3380.0 0.05 -0.0897 -0.4755 1713701 Maybridge4_003400 COc1cccc(c1)C2CCN(CC2)C(=O)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K13 compound treatment 29200.0 -9150.0 -0.15 72040.0 26600.0 0.42 0.1928 0.4285 3064869 Maybridge4_003401 Cc1cc(C)c2c(=O)cc(oc2c1)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K14 compound treatment 49760.0 11400.0 0.19 121840.0 76400.0 1.22 0.994 0.8069 3178689 Maybridge4_003402 FC(F)(F)c1ccc(cc1)C(=O)Nc2cccnc2Sc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K15 compound treatment 45680.0 7330.0 0.12 71920.0 26500.0 0.42 0.3838 0.8746 1294252 Maybridge4_003403 CCOC(=O)c1cnn2c1nc(Sc3ccc(C)cc3)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K16 compound treatment 26160.0 -12200.0 -0.2 61200.0 15700.0 0.25 0.0351 0.1091 1553374 Maybridge4_003404 C1CN(CCO1)c2nnc(c3ccccc3)c(n2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K17 compound treatment 45400.0 7050.0 0.12 112480.0 67000.0 1.07 0.8376 0.7795 1663105 Maybridge4_003405 COc1ccc(Cc2cc(n[nH]c2=O)c3cccs3)c(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K18 compound treatment 67160.0 28800.0 0.48 116560.0 71100.0 1.13 1.1376 0.9256 3064947 Maybridge4_003406 OC[C@H]1OC(Oc2ccc(cc2)c3coc4cc(O)cc(O)c4c3=O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K19 compound treatment 59440.0 21100.0 0.35 110520.0 65100.0 1.04 0.9794 0.8954 1252838 Maybridge4_003407 Cc1cc(C)n(NC(=S)NC2CCCC2)c(=O)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K20 compound treatment 22200.0 -16200.0 -0.27 37840.0 -7620.0 -0.12 -0.2744 -0.9365 1353357 Maybridge4_003408 S=C1CC(Sc2ccccc2N1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K21 compound treatment 27600.0 -10800.0 -0.18 39280.0 -6180.0 -0.1 -0.1951 -0.9613 1332355 Maybridge4_003409 CC(=O)N1CCc2cc(NC(=S)NC3CCCCCC3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K22 compound treatment 25040.0 -13300.0 -0.22 46320.0 864.0 0.01 -0.1457 -0.6615 3064948 Maybridge4_003410 CNC(=O)c1cc(OC)ccc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K23 mock treatment 34960.0 -3390.0 -0.06 45280.0 -176.0 0.0 -0.0416 -0.7416 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 K24 mock treatment 16320.0 -22000.0 -0.36 50840.0 5380.0 0.09 -0.1965 -0.5258 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L01 compound treatment 24320.0 -14000.0 -0.23 68120.0 22700.0 0.36 0.0916 0.2135 3064949 Maybridge4_003411 Cc1ncc(CO)c(/C=N/O)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L02 compound treatment 29560.0 -8790.0 -0.15 56200.0 10700.0 0.17 0.0184 0.0821 2085598 Maybridge4_003412 CSc1sc(=S)sc1SC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L03 compound treatment 29160.0 -9190.0 -0.15 58000.0 12500.0 0.2 0.0341 0.1357 1341478 Maybridge4_003413 NNC(=O)CC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L04 compound treatment 48640.0 10300.0 0.17 112360.0 66900.0 1.07 0.8741 0.8095 1914392 Maybridge4_003414 O=C(c1ccccc1)n2ccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L05 compound treatment 24240.0 -14100.0 -0.23 47920.0 2460.0 0.04 -0.137 -0.5797 3178690 Maybridge4_003415 C(SC1(CC2CC3CC(C2)C1)C3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L06 compound treatment 58000.0 19600.0 0.32 98760.0 53300.0 0.85 0.8301 0.9128 1103414 Maybridge4_003416 OC(=O)C1CCCN1C(=O)OCC2c3ccccc3-c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L07 compound treatment 19200.0 -19200.0 -0.32 47040.0 1580.0 0.03 -0.2057 -0.6486 3064950 Maybridge4_003417 Oc1ccccc1c2cc(c(C#N)c(=O)[nH]2)c3ccc4OCOc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L08 compound treatment 35520.0 -2830.0 -0.05 89960.0 44500.0 0.71 0.4685 0.659 3178691 Maybridge4_003418 FC(F)(F)c1cccc(c1)N2CCN(CC2)C3=Cc4ccccc4C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L09 compound treatment 56560.0 18200.0 0.3 157000.0 112000.0 1.78 1.4696 0.8151 3064952 Maybridge4_003419 O=C(/C=C\1/NCCOC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L10 compound treatment 84880.0 46500.0 0.77 183320.0 138000.0 2.2 2.0968 0.9008 1604086 Maybridge4_003420 Clc1cccc(Cl)c1Cn2nnc(n2)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L11 compound treatment 41320.0 2970.0 0.05 75240.0 29800.0 0.47 0.3703 0.7759 1004954 Maybridge4_003421 N(C(=Nc1ccccc1)Nc2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L12 compound treatment 102480.0 64100.0 1.06 145480.0 100000.0 1.59 1.8758 0.9802 3178692 Maybridge4_003422 CC1CN(CC(C)O1)c2ccc(NC(=S)NCc3ccco3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L13 compound treatment 105120.0 66800.0 1.1 140120.0 94700.0 1.51 1.8462 0.9881 3178693 Maybridge4_003423 FC(F)(F)C(NC(=O)Oc1ccccc1)(Oc2ccccc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L14 compound treatment 83680.0 45300.0 0.75 138080.0 92600.0 1.48 1.573 0.9504 3064954 Maybridge4_003424 COCc1cc(O)nc(SCC(=O)C(C)(C)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L15 compound treatment 52360.0 14000.0 0.23 169040.0 124000.0 1.97 1.5563 0.7847 1022292 Maybridge4_003425 O=C1NC(Cc2ccccc2)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L16 compound treatment 19360.0 -19000.0 -0.31 104920.0 59500.0 0.95 0.4485 0.4492 3064955 Maybridge4_003426 FC(F)(F)c1cc(cc(c1)C(F)(F)F)c2nnn(CC(=O)c3ccc(Cl)cc3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L17 compound treatment 3200.0 -35200.0 -0.58 9880.0 -35600.0 -0.57 -0.8113 -0.9999 1517030 Maybridge4_003427 CC(=O)Oc1ccc(OC(=O)C)c2cc3c(OC(=O)C)ccc(OC(=O)C)c3cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L18 compound treatment 39880.0 1530.0 0.03 110840.0 65400.0 1.04 0.7547 0.724 3064957 Maybridge4_003428 CCN(CC)C(=S)Oc1nc(nc(C)c1CC(=C)C)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L19 compound treatment 55000.0 16600.0 0.27 105280.0 59800.0 0.95 0.8685 0.8753 1414175 Maybridge4_003429 NNC(=O)C1C(C1c2ccccc2)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L20 compound treatment 32200.0 -6150.0 -0.1 52800.0 7340.0 0.12 0.0109 0.0706 1151671 Maybridge4_003430 CC(C)(C)C(=O)CSc1nc2ccccc2c(=O)n1CC3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L21 compound treatment 26480.0 -11900.0 -0.2 43640.0 -1820.0 -0.03 -0.1591 -0.8028 1294591 Maybridge4_003431 C1CCN(CC1)c2cc(nc3ccccc23)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L22 compound treatment 3200.0 -35200.0 -0.58 9320.0 -36100.0 -0.58 -0.8176 -1.0 3178694 Maybridge4_003432 CCCC1=NN(C(=O)/C=C/c2cccs2)C(=O)C1Cc3c(F)cccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L23 mock treatment 27840.0 -10500.0 -0.17 52240.0 6780.0 0.11 -0.0463 -0.2263 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 L24 mock treatment 20320.0 -18000.0 -0.3 45000.0 -456.0 -0.01 -0.2156 -0.7242 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M01 compound treatment 30840.0 -7510.0 -0.12 57920.0 12500.0 0.2 0.0528 0.2253 1614322 Maybridge4_003433 CC(C)NC(=O)N(Cc1ccccc1)Cc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M02 compound treatment 35600.0 -2750.0 -0.05 71520.0 26100.0 0.42 0.2616 0.626 1632856 Maybridge4_003434 CCCCn1c(O)cc(C)c(C#N)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M03 compound treatment 25520.0 -12800.0 -0.21 40000.0 -5460.0 -0.09 -0.2113 -0.9227 3178695 Maybridge4_003435 CSC1=N/C(=C\Nc2cccc(Cl)c2)/C(=O)N1Cc3cccc(Cl)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M04 compound treatment 28720.0 -9630.0 -0.16 43960.0 -1500.0 -0.02 -0.1293 -0.8042 1626500 Maybridge4_003436 S=C(NCC1CC1)Nc2ccc3[nH]ccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M05 compound treatment 27320.0 -11000.0 -0.18 84600.0 39100.0 0.62 0.3124 0.4806 3178774 Maybridge4_003437 FC(F)(F)c1ccncc1C(=O)Nc2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M06 compound treatment 45120.0 6770.0 0.11 141040.0 95600.0 1.52 1.1562 0.7569 3064958 Maybridge4_003438 NNC(=O)CC1=Nn2c(nnc2SC1)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M07 compound treatment 20440.0 -17900.0 -0.3 80920.0 35500.0 0.57 0.1906 0.2988 3178775 Maybridge4_003439 CCN(Cc1cc(Cl)cc(Cl)c1)C(=O)c2cnc(OC)cc2C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M08 compound treatment 26320.0 -12000.0 -0.2 128880.0 83400.0 1.33 0.7997 0.5949 1042478 Maybridge4_003440 CNc1cc(=O)n(C)c(=O)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M09 compound treatment 43760.0 5410.0 0.09 116760.0 71300.0 1.14 0.8667 0.7603 3064959 Maybridge4_003441 Fc1ccc(NC(=O)c2cnccc2C(F)(F)F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M10 compound treatment 28240.0 -10100.0 -0.17 124080.0 78600.0 1.25 0.7681 0.6075 1313888 Maybridge4_003442 COc1cc(ccc1O)C2=NC(O)C(=O)Nc3ccc(Cl)cc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M11 compound treatment 35600.0 -2750.0 -0.05 108680.0 63200.0 1.01 0.6804 0.6745 3064960 Maybridge4_003443 NNC(=O)c1cc(OCC(F)(F)F)nc(OCC(F)(F)F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M12 compound treatment 61400.0 23000.0 0.38 111920.0 66500.0 1.06 1.0181 0.9045 3178776 Maybridge4_003444 Fc1ccc(cc1)c2nnc(CSCc3cccc4ccccc34)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M13 compound treatment 70800.0 32400.0 0.54 111160.0 65700.0 1.05 1.1192 0.9515 3178777 Maybridge4_003445 Clc1ccc(cc1)C(=O)CC(C(=O)c2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M14 compound treatment 49000.0 10600.0 0.18 124920.0 79500.0 1.27 1.0198 0.7976 3064961 Maybridge4_003446 Nn1c(cc(c(C#N)c1=O)C(F)(F)F)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M15 compound treatment 34480.0 -3870.0 -0.06 138520.0 93100.0 1.48 1.0036 0.676 3178778 Maybridge4_003447 CCOC(=O)c1cnn2c1nc(Oc3cc(cc(c3)C(F)(F)F)C(F)(F)F)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M16 compound treatment 35440.0 -2910.0 -0.05 95600.0 50100.0 0.8 0.5311 0.6634 1593342 Maybridge4_003448 CC(C)NC(=O)c1cccc2cccc(Sc3ccccc3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M17 compound treatment 14280.0 -24100.0 -0.4 84000.0 38500.0 0.61 0.1534 0.2097 1609655 Maybridge4_003449 O=c1[nH]nc(cc1CC2CCCCC2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M18 compound treatment 26400.0 -12000.0 -0.2 128480.0 83000.0 1.32 0.7962 0.5951 1690877 Maybridge4_003450 O=c1n(c2ccccc2)c(=O)n3C4CCC(C4)n31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M19 compound treatment 35800.0 -2550.0 -0.04 136280.0 90800.0 1.45 0.9938 0.6862 1634815 Maybridge4_003451 Cc1cc(C)n(NC(=S)NCc2cccs2)c(=O)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M20 compound treatment 18440.0 -19900.0 -0.33 74880.0 29400.0 0.47 0.0992 0.1732 3065001 Maybridge4_003452 C1Sc2ccccc2C3=Nc4ccccc4SC(C13)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M21 compound treatment 10720.0 -27600.0 -0.46 19040.0 -26400.0 -0.42 -0.6203 -0.9992 3065002 Maybridge4_003453 CN(C)/C=C/C(=O)c1ccc(OCc2ccc(Cl)c(Cl)c2)c(C)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M22 compound treatment 24240.0 -14100.0 -0.23 60720.0 15300.0 0.24 0.0073 0.0216 3065003 Maybridge4_003454 NC(=O)c1cc(Cl)ccc1I 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M23 mock treatment 24920.0 -13400.0 -0.22 81200.0 35700.0 0.57 0.246 0.4025 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 M24 mock treatment 22880.0 -15500.0 -0.26 61800.0 16300.0 0.26 0.0036 0.0098 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N01 compound treatment 25720.0 -12600.0 -0.21 37320.0 -8140.0 -0.13 -0.2392 -0.9739 1588083 Maybridge4_003455 CC(=O)Oc1ccc(cc1)c2coc3cc(OC(=O)C)cc(OC(=O)C)c3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N02 compound treatment 13280.0 -25100.0 -0.41 36240.0 -9220.0 -0.15 -0.3965 -0.9029 1124592 Maybridge4_003456 CC1CC2(CCCCC2)N(Cc3ccccc13)S(=O)(=O)c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N03 compound treatment 24960.0 -13400.0 -0.22 68560.0 23100.0 0.37 0.104 0.2422 3065004 Maybridge4_003457 CNC(=S)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N04 compound treatment 14280.0 -24100.0 -0.4 129280.0 83800.0 1.34 0.6637 0.4762 1007974 Maybridge4_003458 O=C(Nc1ccccc1)OC2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N05 compound treatment 2640.0 -35700.0 -0.59 17160.0 -28300.0 -0.45 -0.7358 -0.9913 3178779 Maybridge4_003459 CC(CNc1ccccc1)/C(=N/c2ccccc2)/Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N06 compound treatment 30000.0 -8350.0 -0.14 111360.0 65900.0 1.05 0.6452 0.6091 1711036 Maybridge4_003460 CC1(C)c2ccccc2N3CC(=O)N(CC=C)C31C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N07 compound treatment 24600.0 -13800.0 -0.23 123240.0 77800.0 1.24 0.7161 0.5682 854262 Maybridge4_003461 CC(N)(Cc1cccc(O)c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N08 compound treatment 13560.0 -24800.0 -0.41 120040.0 74600.0 1.19 0.5512 0.4384 1129507 Maybridge4_003462 CC(N(C(=O)c1sc2ccccc2c1Cl)c3ccccn3)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N09 compound treatment 28080.0 -10300.0 -0.17 155600.0 110000.0 1.76 1.1214 0.6358 1387784 Maybridge4_003463 COc1ccc(Sc2ccccc2COC(=O)C)c(c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N10 compound treatment 38400.0 46.3 0.0 143120.0 97700.0 1.56 1.1012 0.7075 1366361 Maybridge4_003464 NNC(=O)Cn1nnc(n1)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N11 compound treatment 49080.0 10700.0 0.18 166560.0 121000.0 1.93 1.4901 0.7687 3178780 Maybridge4_003465 CC1(C)NCS[C@H]1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N12 compound treatment 40400.0 2050.0 0.03 36640.0 -8820.0 -0.14 -0.0755 -0.5223 2078075 Maybridge4_003466 CC[n+]1c(C)csc1Nc2ccc(cc2)N3CC(C)OC(C)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N13 compound treatment 7240.0 -31100.0 -0.51 18440.0 -27000.0 -0.43 -0.6677 -0.9962 3178781 Maybridge4_003467 CCOC(NC(=O)Nc1ccc(Br)cc1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N14 compound treatment 38080.0 -274.0 0.0 123680.0 78200.0 1.25 0.8784 0.7045 3065007 Maybridge4_003468 FC(F)(F)c1cc(=O)oc2cc(NC(=O)c3cc(Cl)cc(Cl)c3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N15 compound treatment 34440.0 -3910.0 -0.06 102320.0 56900.0 0.91 0.5952 0.655 1675436 Maybridge4_003469 CCOC(=O)c1c(C)n(O)c2ccc3nonc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N16 compound treatment 23760.0 -14600.0 -0.24 154160.0 109000.0 1.73 1.0548 0.603 1084802 Maybridge4_003470 CC(C)CCc1c(C)nc(N)nc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N17 compound treatment 19840.0 -18500.0 -0.31 105520.0 60100.0 0.96 0.4608 0.4586 1383041 Maybridge4_003471 Clc1ccc(C(=O)N2CCC(CC2)NC(=O)c3ccccc3)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N18 compound treatment 5840.0 -32500.0 -0.54 18040.0 -27400.0 -0.44 -0.6885 -0.9948 3065008 Maybridge4_003472 CS/C(=N/C(C)(C)C)/Nc1ccccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N19 compound treatment 23760.0 -14600.0 -0.24 110520.0 65100.0 1.04 0.5629 0.5288 1673966 Maybridge4_003473 Cc1c(NC(=O)C(C)(C)C)c(=O)n(c2ccccc2)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N20 compound treatment 19320.0 -19000.0 -0.31 64360.0 18900.0 0.3 -0.0091 -0.0209 1479223 Maybridge4_003474 Cc1cc(Nc2ccc(F)c(Cl)c2)nc(NC(=O)C(C)(C)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N21 compound treatment 1520.0 -36800.0 -0.61 4960.0 -40500.0 -0.65 -0.8863 -0.9996 1920716 Maybridge4_003475 CC(C)COc1ccc(cc1)/C(=N\O)/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N22 compound treatment 5000.0 -33400.0 -0.55 16880.0 -28600.0 -0.46 -0.7114 -0.9956 3178782 Maybridge4_003476 CC(=C)CC1C(=NN(C1=O)S(=O)(=O)c2ccccc2Cl)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N23 mock treatment 29040.0 -9310.0 -0.15 77480.0 32000.0 0.51 0.2522 0.4731 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 N24 mock treatment 29040.0 -9310.0 -0.15 46200.0 744.0 0.01 -0.1003 -0.6507 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O01 compound treatment 17720.0 -20600.0 -0.34 25360.0 -20100.0 -0.32 -0.4673 -0.9995 3178783 Maybridge4_003477 CSC1=N/C(=C\c2ccc(Cl)cc2)/C(=O)N1CCOc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O02 compound treatment 1440.0 -36900.0 -0.61 3680.0 -41800.0 -0.67 -0.9017 -0.999 3065009 Maybridge4_003478 Cc1ccc(OCc2nnc(S)n2C3CCCCC3)c4CCCc41 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O03 compound treatment 23680.0 -14700.0 -0.24 105280.0 59800.0 0.95 0.5029 0.5112 1042314 Maybridge4_003479 CNC(=O)Nc1cccc2cccnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O04 compound treatment 15120.0 -23200.0 -0.38 64440.0 19000.0 0.3 -0.0572 -0.1172 1378461 Maybridge4_003480 S=C(NC1CCCCC1)Nc2ccc3[nH]ccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O05 compound treatment 28800.0 -9550.0 -0.16 133360.0 87900.0 1.4 0.8792 0.6236 3178784 Maybridge4_003481 FC(F)(F)c1ccncc1C(=O)NCc2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O06 compound treatment 10800.0 -27600.0 -0.45 118200.0 72700.0 1.16 0.4982 0.4 3065010 Maybridge4_003482 CC(C)(C)C(=S)Nc1cccc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O07 compound treatment 24560.0 -13800.0 -0.23 131920.0 86500.0 1.38 0.8135 0.5824 3178785 Maybridge4_003483 COc1cccc(CNC(=O)c2cnc(OC)cc2C(F)(F)F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O08 compound treatment 24240.0 -14100.0 -0.23 136760.0 91300.0 1.46 0.8643 0.5864 1115300 Maybridge4_003484 NNC(=O)COc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O09 compound treatment 25400.0 -13000.0 -0.21 144600.0 99100.0 1.58 0.9662 0.6059 3178786 Maybridge4_003485 NC(=O)C1=CN(CCC1C(F)(F)F)C(=O)Nc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O10 compound treatment 23800.0 -14600.0 -0.24 149840.0 104000.0 1.66 1.0066 0.5988 1008942 Maybridge4_003486 Cc1cccc(NC(=O)Nc2cccc(C)c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O11 compound treatment 8400.0 -30000.0 -0.49 57800.0 12300.0 0.2 -0.2105 -0.3956 3178787 Maybridge4_003487 FC(F)(F)COc1ncccc1C(=O)NCc2ccc(Cl)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O12 compound treatment 29800.0 -8550.0 -0.14 72880.0 27400.0 0.44 0.2092 0.4555 1449652 Maybridge4_003488 COC(=O)C(Cc1c[nH]c2ccccc12)NS(=O)(=O)c3ccc(CNC(=O)c4ccccc4)s3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O13 compound treatment 59080.0 20700.0 0.34 115840.0 70400.0 1.12 1.0352 0.8826 3178788 Maybridge4_003489 COC(=O)c1cc2cc(Br)ccc2c(Br)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O14 compound treatment 28040.0 -10300.0 -0.17 127000.0 81500.0 1.3 0.7986 0.6093 1523809 Maybridge4_003490 CCOC(=O)COc1nc(C)c(CC=C)c(C)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O15 compound treatment 23520.0 -14800.0 -0.24 52640.0 7180.0 0.11 -0.0922 -0.341 1444175 Maybridge4_003491 CCOC(=O)c1cnn2c1nc(N3CC(C)CC(C)C3)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O16 compound treatment 2360.0 -36000.0 -0.59 8960.0 -36500.0 -0.58 -0.8315 -0.9999 3065040 Maybridge4_003492 O=C1/C(=C/c2ccc3ccccc3c2)/COc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O17 compound treatment 24640.0 -13700.0 -0.23 119480.0 74000.0 1.18 0.6742 0.5612 3065041 Maybridge4_003493 Cc1cc(CO)cc(C)c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O18 compound treatment 23400.0 -15000.0 -0.25 118120.0 72700.0 1.16 0.6444 0.5442 1280927 Maybridge4_003494 O=c1n(c2ccccc2)c(=O)n3C4CC(C=C4)n31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O19 compound treatment 21120.0 -17200.0 -0.28 112640.0 67200.0 1.07 0.556 0.5018 3065042 Maybridge4_003495 CC1=C(Sc2ccccc2N1)C(=O)Nn3cnc4cccc(F)c4c3=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O20 compound treatment 2080.0 -36300.0 -0.6 20880.0 -24600.0 -0.39 -0.7004 -0.9788 3065043 Maybridge4_003496 Cc1ccc(cc1)C2CC(=Nc3ccccc3S2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O21 compound treatment 27680.0 -10700.0 -0.18 110440.0 65000.0 1.04 0.6078 0.5785 1222795 Maybridge4_003497 CCOC(=O)c1cnn(C(=O)COc2ccc(cc2C(C)(C)C)C(C)(C)C)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O22 compound treatment 1640.0 -36700.0 -0.61 4800.0 -40700.0 -0.65 -0.8867 -0.9994 3065044 Maybridge4_003498 Cc1cc(nc2CC(C)(C)C/C(=N/O)/c12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O23 mock treatment 30960.0 -7390.0 -0.12 96320.0 50900.0 0.81 0.4869 0.594 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 O24 mock treatment 57800.0 19400.0 0.32 58640.0 13200.0 0.21 0.3756 0.9789 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P01 compound treatment 7880.0 -30500.0 -0.5 5680.0 -39800.0 -0.63 -0.804 -0.9934 1411988 Maybridge4_003499 O=C(CC#N)NC(=O)NC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P02 compound treatment 4920.0 -33400.0 -0.55 7040.0 -38400.0 -0.61 -0.8232 -0.9987 1452749 Maybridge4_003500 CC1CC2(CCCCC2)N(Cc3ccccc13)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P03 compound treatment 1520.0 -36800.0 -0.61 4120.0 -41300.0 -0.66 -0.8958 -0.9992 2102798 Maybridge4_003501 COC(=O)/C=C\1/OC(=CC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P04 compound treatment 33640.0 -4710.0 -0.08 69120.0 23700.0 0.38 0.2117 0.5497 1582498 Maybridge4_003502 CC(=O)NC(=O)NCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P05 compound treatment 26480.0 -11900.0 -0.2 62560.0 17100.0 0.27 0.0542 0.1613 3065047 Maybridge4_003503 CCOC(=O)CC1=NC(=O)CS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P06 compound treatment 22880.0 -15500.0 -0.26 123560.0 78100.0 1.24 0.6996 0.5505 1631994 Maybridge4_003504 Cc1ccc2N3CC(=O)N(Cc4ccccc4)C3(C)C(C)(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P07 compound treatment 25200.0 -13200.0 -0.22 128760.0 83300.0 1.33 0.7853 0.5837 3065048 Maybridge4_003505 CC(=O)N1CC(O)C[C@H]1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P08 compound treatment 29800.0 -8550.0 -0.14 137680.0 92200.0 1.47 0.9395 0.6363 3178789 Maybridge4_003506 CN1N=C(C)C(Cc2c(Cl)cccc2Cl)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P09 compound treatment 14320.0 -24000.0 -0.4 69920.0 24500.0 0.39 -0.0048 -0.0087 1247915 Maybridge4_003507 O=C(Oc1ccc(Oc2ccccc2)cc1)N3CCC(CC3)OC(=O)n4ccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P10 compound treatment 26040.0 -12300.0 -0.2 113120.0 67700.0 1.08 0.6189 0.5639 3065049 Maybridge4_003508 CN(C)/N=C(\Cn1nnc(n1)N2CCCC2)/c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P11 compound treatment 34480.0 -3870.0 -0.06 129040.0 83600.0 1.33 0.8968 0.6724 1294581 Maybridge4_003509 OC(=O)c1ccc2cc[nH]c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P12 compound treatment 17200.0 -21200.0 -0.35 54000.0 8540.0 0.14 -0.1506 -0.4019 1153919 Maybridge4_003510 CC(C)(C)c1ccc(NC(=S)NCc2cccnc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P13 compound treatment 42200.0 3850.0 0.06 140200.0 94700.0 1.51 1.1127 0.7362 3178790 Maybridge4_003511 CN(C)C(=O)NC(Nc1cc(C)on1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P14 compound treatment 39720.0 1370.0 0.02 116120.0 70700.0 1.13 0.8123 0.7211 1634696 Maybridge4_003512 OCN1N=C(CCC1=O)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P15 compound treatment 46480.0 8130.0 0.13 127520.0 82100.0 1.31 1.0197 0.7756 1538301 Maybridge4_003513 OC(=O)CCn1nc(Nc2ccccc2)n(c3ccccc3)c1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P16 compound treatment 25160.0 -13200.0 -0.22 84080.0 38600.0 0.62 0.2813 0.4308 3065050 Maybridge4_003514 COCc1nc(S)nc(O)c1Cc2c(F)cccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P17 compound treatment 16640.0 -21700.0 -0.36 71120.0 25700.0 0.41 0.0358 0.0658 1358448 Maybridge4_003515 COc1ccccc1C2CCN(CC2)C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P18 compound treatment 22480.0 -15900.0 -0.26 119080.0 73600.0 1.17 0.6445 0.536 3065051 Maybridge4_003516 CC(C)(C)NC(=S)NCC1CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P19 compound treatment 10840.0 -27500.0 -0.45 34600.0 -10900.0 -0.17 -0.4435 -0.9125 1357507 Maybridge4_003517 Clc1ccc(Nc2ccc(nn2)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P20 compound treatment 1560.0 -36800.0 -0.61 3720.0 -41700.0 -0.67 -0.8998 -0.999 1680143 Maybridge4_003518 Cc1cc(Nc2ccc(F)cc2)nc(SCc3c(Cl)cccc3Cl)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P21 compound treatment 34200.0 -4150.0 -0.07 74320.0 28900.0 0.46 0.2768 0.5951 1714479 Maybridge4_003519 CCOC(=O)N1CCN(CC(O)Cn2c(=O)n(C)c3ncn(C)c3c2=O)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P22 compound treatment 1560.0 -36800.0 -0.61 2880.0 -42600.0 -0.68 -0.9093 -0.9985 3178866 Maybridge4_003520 CCCC1=NN(C(=O)C1CC=C)S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P23 mock treatment 39840.0 1490.0 0.02 41320.0 -4140.0 -0.07 -0.0293 -0.4161 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2058 P24 mock treatment 55880.0 17500.0 0.29 38600.0 -6860.0 -0.11 0.1273 0.4116 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A01 compound treatment 24560.0 -43100.0 -0.71 20280.0 -77900.0 -1.24 -1.3817 -0.9651 3178890 Maybridge4_004577 CC(C)(C)c1ccc(SC(=O)c2ccc(OCC(F)(F)F)nc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A02 compound treatment 36960.0 -30700.0 -0.51 6960.0 -91200.0 -1.45 -1.3871 -0.9006 1333720 Maybridge4_004578 COc1ccc(OCc2ncc(s2)c3ccc4OCCCOc4c3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A03 compound treatment 49520.0 -18200.0 -0.3 8680.0 -89500.0 -1.43 -1.2211 -0.8375 1593366 Maybridge4_004579 Cc1nn(c(N)c1c2nc(cs2)c3ccccc3)c4cc(Cl)ccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A04 compound treatment 74680.0 6990.0 0.12 80200.0 -18000.0 -0.29 -0.1213 -0.3924 3178891 Maybridge4_004580 Cc1ccc(cc1F)c2nc(cs2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A05 compound treatment 116040.0 48300.0 0.8 169760.0 71600.0 1.14 1.3708 0.9848 3065742 Maybridge4_004581 FC(F)(F)Oc1ccc(cc1)C(=O)Nc2ccc(nc2)N3CCC(CC3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A06 compound treatment 153160.0 85500.0 1.41 214920.0 117000.0 1.86 2.313 0.9907 3178892 Maybridge4_004582 Cc1c(C#N)c(SCc2cccc(c2)C(F)(F)F)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A07 compound treatment 80280.0 12600.0 0.21 35200.0 -63000.0 -1.0 -0.5631 -0.5492 3178893 Maybridge4_004583 CCOC(=O)c1cc(C#N)c(Sc2ccc(C)cc2)nc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A08 compound treatment 137960.0 70300.0 1.16 47480.0 -50700.0 -0.81 0.2485 0.1758 3065743 Maybridge4_004584 Cn1nc(c2cccc(c2)C3OCCO3)c(=O)n(C)c1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A09 compound treatment 128320.0 60600.0 1.0 33480.0 -64700.0 -1.03 -0.0218 -0.0152 3178894 Maybridge4_004585 Cc1nc(cs1)C(=N)NC(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A10 compound treatment 66160.0 -1530.0 -0.03 20880.0 -77300.0 -1.23 -0.8893 -0.7215 3065744 Maybridge4_004586 CC1=N/C(=C\c2sccc2C)/C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A11 compound treatment 172480.0 105000.0 1.73 108200.0 10000.0 0.16 1.3358 0.769 1220314 Maybridge4_004587 Cc1cc(C)n(Cc2ccccc2)c(=O)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A12 compound treatment 193800.0 126000.0 2.08 174880.0 76700.0 1.22 2.3361 0.9678 3178895 Maybridge4_004588 Cc1ccccc1c2nnc(o2)c3cc(nn3Cc4ccc(F)cc4)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A13 compound treatment 148320.0 80600.0 1.33 144240.0 46000.0 0.73 1.46 0.9606 3178896 Maybridge4_004589 FC(F)(F)COc1ccc(cn1)c2nnc(SCc3ccccc3C(F)(F)F)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A14 compound treatment 11840.0 -55900.0 -0.92 11520.0 -86700.0 -1.38 -1.6289 -0.9807 3065746 Maybridge4_004590 CN(C)/C=C/C(=O)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A15 compound treatment 122760.0 55100.0 0.91 137880.0 39700.0 0.63 1.0899 0.9843 3178897 Maybridge4_004591 CCOC(=O)c1cc(C#N)c(nc1C(F)(F)F)N2CCN(CC2)C(=O)c3snnc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A16 compound treatment 111680.0 44000.0 0.73 177720.0 79500.0 1.27 1.4096 0.9651 3065747 Maybridge4_004592 CC1CCCCN1C(=S)Nc2cccc(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A17 compound treatment 136000.0 68300.0 1.13 201680.0 103000.0 1.65 1.9635 0.9828 3178898 Maybridge4_004593 FC(F)(F)c1ccc(nc1)c2nnc(c3ccccn3)c(n2)c4ccccn4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A18 compound treatment 52120.0 -15600.0 -0.26 74120.0 -24100.0 -0.38 -0.4532 -0.981 3065748 Maybridge4_004594 CC(C)n1c(=S)[nH]c2cc(ccc12)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A19 compound treatment 24800.0 -42900.0 -0.71 46600.0 -51600.0 -0.82 -1.0822 -0.9972 3178899 Maybridge4_004595 COc1ccc(OCC(=N)NC(=S)Nc2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A20 compound treatment 19760.0 -47900.0 -0.79 38120.0 -60100.0 -0.96 -1.2366 -0.9955 3065749 Maybridge4_004596 Clc1ccc(NC(=C(C#N)C#N)NC(=O)c2ccccc2Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A21 compound treatment 17920.0 -49800.0 -0.82 19920.0 -78300.0 -1.25 -1.4632 -0.9795 3178900 Maybridge4_004597 FC(F)(F)c1cc(nc(Sc2ccccc2NC(=O)c3cccs3)c1C#N)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A22 mock treatment 53120.0 -14600.0 -0.24 131160.0 33000.0 0.53 0.2013 0.3485 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A23 mock treatment 41520.0 -26200.0 -0.43 71600.0 -26600.0 -0.42 -0.6053 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 A24 mock treatment 25520.0 -42200.0 -0.7 65720.0 -32500.0 -0.52 -0.8583 -0.9894 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B01 mock treatment 79640.0 11900.0 0.2 103480.0 5280.0 0.08 0.1989 0.9279 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B02 mock treatment 119600.0 51900.0 0.86 112880.0 14700.0 0.23 0.7713 0.8684 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B03 mock treatment 158320.0 90600.0 1.5 145760.0 47600.0 0.76 1.5938 0.9504 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B04 mock treatment 152480.0 84800.0 1.4 161880.0 63700.0 1.01 1.7073 0.9875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B05 mock treatment 161720.0 94000.0 1.55 236520.0 138000.0 2.2 2.6564 0.9852 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B06 mock treatment 176760.0 109000.0 1.8 217880.0 120000.0 1.91 2.6219 0.9996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B07 mock treatment 206160.0 138000.0 2.29 174800.0 76600.0 1.22 2.4795 0.9569 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B08 mock treatment 214440.0 147000.0 2.42 212920.0 115000.0 1.83 3.0058 0.9904 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B09 mock treatment 198440.0 131000.0 2.16 214040.0 116000.0 1.85 2.8316 0.997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B10 mock treatment 228080.0 160000.0 2.65 214560.0 116000.0 1.85 3.1835 0.9848 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B11 mock treatment 232520.0 165000.0 2.72 172400.0 74200.0 1.18 2.7601 0.9304 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B12 mock treatment 238120.0 170000.0 2.81 222880.0 125000.0 1.99 3.3944 0.9855 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B13 mock treatment 221560.0 154000.0 2.54 198240.0 100000.0 1.59 2.9234 0.9748 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B14 mock treatment 229000.0 161000.0 2.66 210000.0 112000.0 1.78 3.1428 0.9809 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B15 mock treatment 227680.0 160000.0 2.64 195800.0 97600.0 1.56 2.9674 0.9681 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B16 mock treatment 219080.0 151000.0 2.5 195000.0 96800.0 1.54 2.858 0.9731 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B17 mock treatment 191760.0 124000.0 2.05 217800.0 120000.0 1.91 2.796 0.9994 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B18 mock treatment 169000.0 101000.0 1.67 178080.0 79900.0 1.27 2.0827 0.9909 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B19 mock treatment 166360.0 98700.0 1.63 195400.0 97200.0 1.55 2.2471 0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B20 mock treatment 138800.0 71100.0 1.17 194600.0 96400.0 1.54 1.9164 0.9912 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B21 mock treatment 161240.0 93500.0 1.54 151080.0 52900.0 0.84 1.6879 0.9594 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B22 mock treatment 116080.0 48400.0 0.8 142600.0 44400.0 0.71 1.0652 0.9982 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B23 mock treatment 93080.0 25400.0 0.42 133720.0 35500.0 0.57 0.6966 0.989 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 B24 mock treatment 55840.0 -11900.0 -0.2 89160.0 -9040.0 -0.14 -0.2403 -0.9887 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C01 compound treatment 64120.0 -3570.0 -0.06 48120.0 -50100.0 -0.8 -0.6062 -0.7573 3065750 Maybridge4_004598 FC(F)(F)c1cccc(NC(=O)CCn2cccc(c2=O)C(F)(F)F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C02 compound treatment 5560.0 -62100.0 -1.03 5320.0 -92900.0 -1.48 -1.7721 -0.9839 3178901 Maybridge4_004599 Oc1ccc2c(CSc3ccc(Cl)cc3)cc(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C03 compound treatment 86880.0 19200.0 0.32 11560.0 -86600.0 -1.38 -0.7525 -0.5311 3178902 Maybridge4_004600 CN(CCOC(=O)c1snnc1C)c2ccc(C#N)cn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C04 compound treatment 84800.0 17100.0 0.28 72160.0 -26000.0 -0.42 -0.0938 -0.1869 1339676 Maybridge4_004601 Cn1nc(cc1C(=O)Nc2cccnc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C05 compound treatment 74360.0 6670.0 0.11 132920.0 34700.0 0.55 0.4691 0.8314 3065771 Maybridge4_004602 CCCNC(=O)Nc1ccc(nc1)N2CCC(CC2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C06 compound treatment 43080.0 -24600.0 -0.41 78720.0 -19500.0 -0.31 -0.5069 -0.9912 1741890 Maybridge4_004603 Cc1cc(C(=O)Nc2ccc(C)cc2)n(Cc3ccc(C)cc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C07 compound treatment 106240.0 38500.0 0.64 92680.0 -5520.0 -0.09 0.3877 0.6036 3065772 Maybridge4_004604 CCOC(=O)c1cc(C#N)c(Nc2ccccc2OC)nc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C08 compound treatment 180920.0 113000.0 1.87 108400.0 10200.0 0.16 1.4366 0.7657 3065773 Maybridge4_004605 N#Cc1ccc(nc1)N2CCCNCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C09 compound treatment 175160.0 107000.0 1.77 84720.0 -13500.0 -0.21 1.1024 0.6169 3065774 Maybridge4_004606 Cc1nc(cs1)C(=N)NC(=O)c2ccc(OC(F)(F)F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C10 compound treatment 203800.0 136000.0 2.25 91720.0 -6480.0 -0.1 1.5156 0.6739 3065775 Maybridge4_004607 N[C@@H](Cc1ccc(OC(F)(F)F)cc1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C11 compound treatment 156320.0 88600.0 1.46 133400.0 35200.0 0.56 1.4312 0.9134 3065776 Maybridge4_004608 Cn1c(SCC(=O)Nc2cccc(Cl)c2)nnc1c3ccc(OCC(F)(F)F)nc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C12 compound treatment 94120.0 26400.0 0.44 73720.0 -24500.0 -0.39 0.0325 0.0556 3065777 Maybridge4_004609 Cc1cc(nn1C(C)(C)C)C(=O)Nc2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C13 compound treatment 78880.0 11200.0 0.18 69200.0 -29000.0 -0.46 -0.1963 -0.3943 3178903 Maybridge4_004610 CSc1nnc(c2cc(OCC(F)(F)F)nc(OCC(F)(F)F)c2)n1Cc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C14 compound treatment 50840.0 -16900.0 -0.28 52400.0 -45800.0 -0.73 -0.7129 -0.9126 3065778 Maybridge4_004611 Fc1ccc(SCC(=O)C2(CC3CC4CC(C3)C2)C4)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C15 compound treatment 94720.0 27000.0 0.45 122240.0 24000.0 0.38 0.5864 0.9971 3178904 Maybridge4_004612 FC(F)(F)c1ccc(nc1)c2nnc(SCC(=O)Nc3cccc(Cl)c3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C16 compound treatment 171320.0 104000.0 1.71 176160.0 78000.0 1.24 2.0882 0.9877 3065781 Maybridge4_004613 Cc1cccc(NC(=S)N2CCCCC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C17 compound treatment 15640.0 -52100.0 -0.86 24080.0 -74100.0 -1.18 -1.443 -0.9878 3178905 Maybridge4_004614 Fc1cccc(c1)C(=O)CSC2=NNC(S2)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C18 compound treatment 115560.0 47900.0 0.79 139960.0 41800.0 0.67 1.0293 0.9964 3065782 Maybridge4_004615 Cn1c(SCC=C)ncc1c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C19 compound treatment 76840.0 9150.0 0.15 110920.0 12700.0 0.2 0.2501 0.9895 3178906 Maybridge4_004616 Cc1ccc(NC(=S)NC(=N)COc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C20 compound treatment 57160.0 -10500.0 -0.17 99920.0 1720.0 0.03 -0.1036 -0.5885 3065783 Maybridge4_004617 Sc1nnc(SCC2CC2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C21 compound treatment 90120.0 22400.0 0.37 145760.0 47600.0 0.76 0.7978 0.9457 1187470 Maybridge4_004618 NC(=S)c1ccc(nc1)n2cncn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C22 mock treatment 75320.0 7630.0 0.13 144520.0 46300.0 0.74 0.611 0.8159 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C23 mock treatment 53840.0 -13900.0 -0.23 110200.0 12000.0 0.19 -0.0265 -0.0888 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 C24 mock treatment 35800.0 -31900.0 -0.53 86960.0 -11200.0 -0.18 -0.499 -0.8972 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D01 mock treatment 55800.0 -11900.0 -0.2 74920.0 -23300.0 -0.37 -0.4012 -0.9557 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D02 mock treatment 69160.0 1470.0 0.02 118040.0 19800.0 0.32 0.2407 0.759 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D03 mock treatment 52640.0 -15100.0 -0.25 119120.0 20900.0 0.33 0.06 0.1444 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D04 mock treatment 89320.0 21600.0 0.36 122400.0 24200.0 0.39 0.5251 0.9993 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D05 mock treatment 113760.0 46100.0 0.76 146960.0 48800.0 0.78 1.0872 0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D06 mock treatment 138960.0 71300.0 1.18 145480.0 47300.0 0.75 1.3647 0.9768 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D07 mock treatment 140880.0 73200.0 1.21 142680.0 44500.0 0.71 1.3555 0.9677 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D08 mock treatment 145640.0 77900.0 1.29 136400.0 38200.0 0.61 1.3403 0.9416 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D09 mock treatment 136160.0 68500.0 1.13 143440.0 45200.0 0.72 1.309 0.9764 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D10 mock treatment 147480.0 79800.0 1.32 157000.0 58800.0 0.94 1.594 0.9861 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D11 mock treatment 138760.0 71100.0 1.17 152520.0 54300.0 0.87 1.4417 0.9888 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D12 mock treatment 154320.0 86600.0 1.43 147120.0 48900.0 0.78 1.5625 0.9593 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D13 mock treatment 141920.0 74200.0 1.23 143720.0 45500.0 0.73 1.3794 0.9687 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D14 mock treatment 139160.0 71500.0 1.18 137080.0 38900.0 0.62 1.2723 0.9548 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D15 mock treatment 140320.0 72600.0 1.2 150160.0 52000.0 0.83 1.4333 0.9837 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D16 mock treatment 148560.0 80900.0 1.33 139840.0 41600.0 0.66 1.4132 0.948 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D17 mock treatment 137280.0 69600.0 1.15 145800.0 47600.0 0.76 1.3487 0.9797 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D18 mock treatment 144000.0 76300.0 1.26 141320.0 43100.0 0.69 1.3766 0.9594 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D19 mock treatment 128680.0 61000.0 1.01 165240.0 67000.0 1.07 1.4674 0.9996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D20 mock treatment 123720.0 56000.0 0.92 148360.0 50200.0 0.8 1.2193 0.9974 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D21 mock treatment 75080.0 7390.0 0.12 132000.0 33800.0 0.54 0.4671 0.8457 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D22 mock treatment 54160.0 -13500.0 -0.22 133120.0 34900.0 0.56 0.2356 0.3928 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D23 mock treatment 88600.0 20900.0 0.35 103800.0 5600.0 0.09 0.3071 0.8616 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 D24 mock treatment 37080.0 -30600.0 -0.51 67400.0 -30800.0 -0.49 -0.7045 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E01 compound treatment 37000.0 -30700.0 -0.51 23240.0 -75000.0 -1.19 -1.2031 -0.9271 3178907 Maybridge4_004619 FC(F)(F)c1cccn(CCC(=O)Sc2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E02 compound treatment 44160.0 -23500.0 -0.39 13240.0 -85000.0 -1.35 -1.2322 -0.8747 1539590 Maybridge4_004620 Oc1ccc2c(CSc3ccccn3)cc(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E03 compound treatment 32800.0 -34900.0 -0.58 10120.0 -88100.0 -1.4 -1.4 -0.9226 3178908 Maybridge4_004621 NC(=S)c1ccc(nc1)N2CCC(CC2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E04 compound treatment 7000.0 -60700.0 -1.0 8400.0 -89800.0 -1.43 -1.7205 -0.9848 3178909 Maybridge4_004622 Cc1cccc(Cl)c1OC(=O)c2cc(nn2C)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E05 compound treatment 98760.0 31100.0 0.51 124600.0 26400.0 0.42 0.6601 0.9952 3065784 Maybridge4_004623 OC(=O)CCn1cc(ccc1=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E06 compound treatment 9480.0 -58200.0 -0.96 10160.0 -88000.0 -1.4 -1.6717 -0.9829 1605604 Maybridge4_004624 Cc1cc(C(=O)Sc2ccccc2)n(Cc3ccc(C)cc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E07 compound treatment 102920.0 35200.0 0.58 106800.0 8600.0 0.14 0.5081 0.8505 3065785 Maybridge4_004625 FC(F)(F)c1cccn(Cc2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E08 compound treatment 40360.0 -27300.0 -0.45 25720.0 -72500.0 -1.16 -1.1359 -0.9159 3178983 Maybridge4_004626 O=c1[nH]nc(SCc2ccccc2)n1c3ccc(OCc4ccccc4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E09 compound treatment 132440.0 64700.0 1.07 79480.0 -18700.0 -0.3 0.5447 0.4909 3065786 Maybridge4_004627 Cn1c(S)nnc1Cn2cc(ccc2=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E10 compound treatment 57320.0 -10400.0 -0.17 34520.0 -63700.0 -1.01 -0.8388 -0.8149 3178984 Maybridge4_004628 CC(=O)N/C(=C/c1ccc(Cl)c(Cl)c1)/C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E11 compound treatment 106640.0 38900.0 0.64 76640.0 -21600.0 -0.34 0.2116 0.2903 3065787 Maybridge4_004629 Cn1c(SCc2ccc(cc2)C(F)(F)F)nnc1c3ccc(OCC(F)(F)F)nc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E12 compound treatment 145560.0 77900.0 1.29 136480.0 38300.0 0.61 1.3403 0.942 3178985 Maybridge4_004630 Clc1ccc(cc1)c2nnc(SCC3CC3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E13 compound treatment 140920.0 73200.0 1.21 131240.0 33000.0 0.53 1.2271 0.9307 3178986 Maybridge4_004631 Cc1ccccc1NC(=O)c2cccc(Cn3cc(ccc3=O)C(F)(F)F)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E14 compound treatment 81960.0 14300.0 0.24 85240.0 -13000.0 -0.21 0.0204 0.0652 1516971 Maybridge4_004632 Cc1ccc(cc1)C(=O)CSc2nnc(o2)c3cc(nn3Cc4cccc(C)c4)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E15 compound treatment 120400.0 52700.0 0.87 126760.0 28600.0 0.46 0.9371 0.9543 3178987 Maybridge4_004633 NNC(=N)c1ccc(cn1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E16 compound treatment 105880.0 38200.0 0.63 124040.0 25800.0 0.41 0.7369 0.9787 3065788 Maybridge4_004634 CC(C)N(CCC#N)CN1C(=O)c2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E17 compound treatment 33800.0 -33900.0 -0.56 38160.0 -60000.0 -0.96 -1.0723 -0.9673 3065812 Maybridge4_004635 CC(C)c1ccc(NC(=O)CSC2=NNC(S2)c3ccccn3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E18 compound treatment 76640.0 8950.0 0.15 97080.0 -1120.0 -0.02 0.0918 0.617 3065813 Maybridge4_004636 Clc1ccc(N/C(=N\C#N)/Oc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E19 compound treatment 79320.0 11600.0 0.19 109080.0 10900.0 0.17 0.2583 0.9987 1232015 Maybridge4_004637 Sc1nc2CCCCc2c(c3cccs3)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E20 compound treatment 149880.0 82200.0 1.36 135440.0 37200.0 0.59 1.379 0.9312 3065814 Maybridge4_004638 CC(Sc1ccc(C)cc1)C(=O)c2ccc(C)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E21 compound treatment 32360.0 -35300.0 -0.58 58280.0 -39900.0 -0.64 -0.8624 -0.9991 3065815 Maybridge4_004639 CCOC(=O)c1nc(C)nc(Sc2nnc([nH]2)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E22 mock treatment 80440.0 12700.0 0.21 113520.0 15300.0 0.24 0.3214 0.9973 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E23 mock treatment 43160.0 -24500.0 -0.4 79160.0 -19000.0 -0.3 -0.501 -0.9899 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 E24 mock treatment 37760.0 -29900.0 -0.49 67160.0 -31000.0 -0.49 -0.6992 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F01 mock treatment 87000.0 19300.0 0.32 84320.0 -13900.0 -0.22 0.0689 0.1776 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F02 mock treatment 68320.0 626.0 0.01 109000.0 10800.0 0.17 0.129 0.7482 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F03 mock treatment 59280.0 -8410.0 -0.14 100960.0 2760.0 0.04 -0.0671 -0.4608 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F04 mock treatment 80520.0 12800.0 0.21 133080.0 34900.0 0.56 0.5428 0.9125 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F05 mock treatment 94840.0 27100.0 0.45 135840.0 37600.0 0.6 0.741 0.9897 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F06 mock treatment 118560.0 50900.0 0.84 145000.0 46800.0 0.75 1.1212 0.9983 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F07 mock treatment 113680.0 46000.0 0.76 135080.0 36900.0 0.59 0.9524 0.992 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F08 mock treatment 96520.0 28800.0 0.48 123480.0 25300.0 0.4 0.6214 0.9966 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F09 mock treatment 134840.0 67100.0 1.11 134800.0 36600.0 0.58 1.1962 0.9551 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F10 mock treatment 137720.0 70000.0 1.16 136080.0 37900.0 0.6 1.2443 0.9541 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F11 mock treatment 149320.0 81600.0 1.35 126680.0 28500.0 0.45 1.2737 0.8958 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F12 mock treatment 154680.0 87000.0 1.44 137520.0 39300.0 0.63 1.4585 0.9309 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F13 mock treatment 154240.0 86500.0 1.43 144480.0 46300.0 0.74 1.5318 0.9527 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F14 mock treatment 130480.0 62800.0 1.04 137200.0 39000.0 0.62 1.1724 0.9701 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F15 mock treatment 135200.0 67500.0 1.11 131000.0 32800.0 0.52 1.1576 0.9405 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F16 mock treatment 96120.0 28400.0 0.47 114680.0 16500.0 0.26 0.5175 0.9624 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F17 mock treatment 138640.0 70900.0 1.17 146040.0 47800.0 0.76 1.3673 0.9784 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F18 mock treatment 112440.0 44700.0 0.74 122160.0 24000.0 0.38 0.7923 0.9529 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F19 mock treatment 100640.0 32900.0 0.54 139520.0 41300.0 0.66 0.8502 0.9955 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F20 mock treatment 90320.0 22600.0 0.37 119840.0 21600.0 0.34 0.508 0.9992 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F21 mock treatment 75600.0 7910.0 0.13 106400.0 8200.0 0.13 0.1847 1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F22 mock treatment 51880.0 -15800.0 -0.26 128880.0 30700.0 0.49 0.1612 0.2908 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F23 mock treatment 47640.0 -20100.0 -0.33 79760.0 -18400.0 -0.29 -0.4419 -0.9982 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 F24 mock treatment 40240.0 -27500.0 -0.45 82000.0 -16200.0 -0.26 -0.5031 -0.9644 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G01 compound treatment 48560.0 -19100.0 -0.32 25880.0 -72300.0 -1.15 -1.0384 -0.8688 3065816 Maybridge4_004640 Cc1nc(N)nc(CSc2ccccc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G02 compound treatment 27320.0 -40400.0 -0.67 10480.0 -87700.0 -1.4 -1.4599 -0.9426 3065817 Maybridge4_004641 Oc1ccc2c(CSc3nnc([nH]3)c4cccs4)cc(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G03 compound treatment 50880.0 -16800.0 -0.28 11320.0 -86900.0 -1.38 -1.1754 -0.8323 1387671 Maybridge4_004642 CN(CCOC(=O)Nc1cccc(Cl)c1)c2ccc(C#N)cn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G04 compound treatment 6520.0 -61200.0 -1.01 9080.0 -89100.0 -1.42 -1.7185 -0.986 1420583 Maybridge4_004643 Clc1ccc(CSc2n[nH]c(=O)n2C3CC4CC3C=C4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G05 compound treatment 82520.0 14800.0 0.24 111560.0 13400.0 0.21 0.3236 0.9976 3178988 Maybridge4_004644 COC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G06 compound treatment 15400.0 -52300.0 -0.86 36800.0 -61400.0 -0.98 -1.3024 -0.998 3065818 Maybridge4_004645 Cc1cc(nn1Cc2ccc(C)cc2)C(=O)Sc3cccc(Cl)c3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G07 compound treatment 93360.0 25700.0 0.42 103440.0 5240.0 0.08 0.3586 0.8305 3178989 Maybridge4_004646 FC(F)(F)c1cccn(CC(=O)c2ccc(Cl)cc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G08 compound treatment 9760.0 -57900.0 -0.96 10040.0 -88200.0 -1.41 -1.6698 -0.9824 1219573 Maybridge4_004647 CC(C)(C)c1cc(NC(=O)CSc2n[nH]c(=O)n2c3ccc4OCCOc4c3)cc(c1)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G09 compound treatment 72080.0 4390.0 0.07 49560.0 -48600.0 -0.78 -0.497 -0.6383 3065819 Maybridge4_004648 CCOC(=O)c1cnc(nc1Sc2nnc([nH]2)c3cccs3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G10 compound treatment 106640.0 38900.0 0.64 81240.0 -17000.0 -0.27 0.2634 0.3777 1396971 Maybridge4_004649 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c2nnc(S)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G11 compound treatment 10840.0 -56900.0 -0.94 10840.0 -87400.0 -1.39 -1.6482 -0.9816 3065820 Maybridge4_004650 CCOC(=O)c1cc(C#N)c(Sc2ccccc2NC(=O)c3ccccc3)nc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G12 compound treatment 47080.0 -20600.0 -0.34 49880.0 -48300.0 -0.77 -0.7852 -0.9326 1227698 Maybridge4_004651 Cc1cccc(Cn2nc(cc2C(=O)Nc3cccnc3)C(C)(C)C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G13 compound treatment 13240.0 -54500.0 -0.9 13680.0 -84500.0 -1.35 -1.5882 -0.9807 3065822 Maybridge4_004652 FC(F)(F)c1ccc(=O)n(Cc2cccc(c2)C(=O)Sc3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G14 compound treatment 111000.0 43300.0 0.71 134120.0 35900.0 0.57 0.9103 0.9939 3178991 Maybridge4_004653 CCOC(=O)C1CCN(CC1)c2nc(c(cc2C#N)C(=O)OCC)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G15 compound treatment 99960.0 32300.0 0.53 137760.0 39600.0 0.63 0.8225 0.9965 1653461 Maybridge4_004654 CC(=O)N1CCN(CC1)c2nc3ccc(Cl)cc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G16 compound treatment 88920.0 21200.0 0.35 118880.0 20700.0 0.33 0.4808 0.9995 3178992 Maybridge4_004655 CC(C)N(CCC#N)C(=S)Nc1c(C)cccc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G17 compound treatment 122120.0 54400.0 0.9 144680.0 46500.0 0.74 1.1591 0.9954 3065823 Maybridge4_004656 COC(=N)NC(=S)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G18 compound treatment 91000.0 23300.0 0.38 123640.0 25400.0 0.41 0.5587 0.9997 1122990 Maybridge4_004657 CC(C)NC(=O)Nc1nc(Nc2ccc(Cl)cc2)n[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G19 compound treatment 101560.0 33900.0 0.56 121160.0 23000.0 0.37 0.654 0.9789 3178993 Maybridge4_004658 N1N=C(NC1c2cccnc2)c3cnccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G20 compound treatment 67800.0 106.0 0.0 105720.0 7520.0 0.12 0.086 0.7173 1235857 Maybridge4_004659 Cc1c(C#N)c(=N)n(nc1C(=O)Nc2ccccc2)c3ccc(cc3)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G21 compound treatment 96280.0 28600.0 0.47 100440.0 2240.0 0.04 0.3589 0.7584 3178994 Maybridge4_004660 CCOC(=O)c1sc2nc(c(cc2c1NC(=O)C)C(=O)OCC)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G22 mock treatment 55720.0 -12000.0 -0.2 109240.0 11000.0 0.18 -0.0154 -0.0581 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G23 mock treatment 35040.0 -32700.0 -0.54 73960.0 -24200.0 -0.39 -0.6544 -0.9867 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 G24 mock treatment 25600.0 -42100.0 -0.69 48520.0 -49700.0 -0.79 -1.0513 -0.9979 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H01 mock treatment 23520.0 -44200.0 -0.73 43200.0 -55000.0 -0.88 -1.1355 -0.9958 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H02 mock treatment 38000.0 -29700.0 -0.49 90840.0 -7360.0 -0.12 -0.4296 -0.8523 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H03 mock treatment 69000.0 1310.0 0.02 83960.0 -14200.0 -0.23 -0.1453 -0.6371 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H04 mock treatment 80040.0 12300.0 0.2 115880.0 17700.0 0.28 0.3433 0.9874 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H05 mock treatment 110400.0 42700.0 0.7 132440.0 34200.0 0.55 0.8844 0.992 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H06 mock treatment 119560.0 51900.0 0.86 120400.0 22200.0 0.35 0.8556 0.9236 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H07 mock treatment 105960.0 38300.0 0.63 131040.0 32800.0 0.52 0.8167 0.9956 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H08 mock treatment 101120.0 33400.0 0.55 121800.0 23600.0 0.38 0.6561 0.9826 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H09 mock treatment 119200.0 51500.0 0.85 114600.0 16400.0 0.26 0.786 0.8837 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H10 mock treatment 118520.0 50800.0 0.84 121400.0 23200.0 0.37 0.8547 0.9322 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H11 mock treatment 126280.0 58600.0 0.97 139560.0 41400.0 0.66 1.15 0.9825 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H12 mock treatment 132600.0 64900.0 1.07 137800.0 39600.0 0.63 1.2039 0.9682 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H13 mock treatment 128080.0 60400.0 1.0 133280.0 35100.0 0.56 1.1002 0.9626 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H14 mock treatment 119840.0 52100.0 0.86 112840.0 14600.0 0.23 0.7736 0.8675 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H15 mock treatment 104560.0 36900.0 0.61 126560.0 28400.0 0.45 0.7499 0.9893 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H16 mock treatment 78680.0 11000.0 0.18 115120.0 16900.0 0.27 0.3189 0.9814 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H17 mock treatment 100640.0 32900.0 0.54 132800.0 34600.0 0.55 0.7745 1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H18 mock treatment 99320.0 31600.0 0.52 116320.0 18100.0 0.29 0.5733 0.961 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H19 mock treatment 122440.0 54700.0 0.9 145800.0 47600.0 0.76 1.1755 0.9962 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H20 mock treatment 73240.0 5550.0 0.09 115120.0 16900.0 0.27 0.2554 0.8969 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H21 mock treatment 63400.0 -4290.0 -0.07 107200.0 9000.0 0.14 0.0513 0.3206 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H22 mock treatment 49920.0 -17800.0 -0.29 94040.0 -4160.0 -0.07 -0.2544 -0.8456 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H23 mock treatment 40760.0 -26900.0 -0.44 87440.0 -10800.0 -0.17 -0.4357 -0.9142 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 H24 mock treatment 15440.0 -52300.0 -0.86 62120.0 -36100.0 -0.58 -1.0166 -0.9806 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I01 compound treatment 23640.0 -44100.0 -0.73 15440.0 -82800.0 -1.32 -1.447 -0.9606 3178995 Maybridge4_004661 FC(F)(F)COc1ccc(cn1)C(=O)NC(=O)NN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I02 compound treatment 41640.0 -26100.0 -0.43 8560.0 -89600.0 -1.43 -1.3144 -0.8809 3065824 Maybridge4_004662 Oc1nnc(SCc2cc(=O)oc3cc(O)ccc23)n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I03 compound treatment 4520.0 -63200.0 -1.04 5440.0 -92800.0 -1.48 -1.7828 -0.9854 3178996 Maybridge4_004663 Cc1noc(COc2ccccc2)c1C(=O)Sc3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I04 compound treatment 64160.0 -3530.0 -0.06 48120.0 -50100.0 -0.8 -0.6057 -0.7568 3065825 Maybridge4_004664 Cc1c(C#N)c(Sc2ccccc2Cl)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I05 compound treatment 62120.0 -5570.0 -0.09 133680.0 35500.0 0.57 0.3348 0.5844 3178997 Maybridge4_004665 COC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)Nc3ccc(Cl)cc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I06 compound treatment 33400.0 -34300.0 -0.57 61920.0 -36300.0 -0.58 -0.8092 -0.9999 1622413 Maybridge4_004666 COc1ccc(SC(=O)c2cc(C)n(Cc3c(Cl)cccc3Cl)n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I07 compound treatment 95000.0 27300.0 0.45 86360.0 -11800.0 -0.19 0.1853 0.3791 3178998 Maybridge4_004667 FC(F)(F)c1ccc(=O)n(CC(=O)c2ccc(C#N)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I08 compound treatment 78440.0 10700.0 0.18 67760.0 -30400.0 -0.49 -0.2177 -0.4213 3065827 Maybridge4_004668 CSc1n[nH]c(=O)n1c2ccc3OCCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I09 compound treatment 8280.0 -59400.0 -0.98 9640.0 -88600.0 -1.41 -1.6916 -0.9842 3065847 Maybridge4_004669 CCOC(=O)c1cc(C#N)c(Sc2n[nH]c(=O)n2Cc3ccc(cc3)C(F)(F)F)nc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I10 compound treatment 84320.0 16600.0 0.27 76040.0 -22200.0 -0.35 -0.0557 -0.1245 3065848 Maybridge4_004670 CC(C)(C)NC(=O)[C@H]1C[C@H]2CCCC[C@H]2CN1C(=O)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I11 compound treatment 114440.0 46700.0 0.77 100320.0 2120.0 0.03 0.5695 0.7373 3065849 Maybridge4_004671 FC(F)(F)c1ccc(nc1)C(=N)NC(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I12 compound treatment 120080.0 52400.0 0.86 110800.0 12600.0 0.2 0.7535 0.8487 1418931 Maybridge4_004672 Cc1cc(C)c(Cn2nc(cc2C(=O)NN3CCOCC3)C(C)(C)C)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I13 compound treatment 43560.0 -24100.0 -0.4 47800.0 -50400.0 -0.8 -0.8497 -0.9476 3065850 Maybridge4_004673 FC(F)(F)c1ccc(=O)n(Cc2cccc(c2)C(=O)NC(=N)c3ccc(Cl)cc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I14 compound treatment 102720.0 35000.0 0.58 125480.0 27300.0 0.43 0.7163 0.9901 1208016 Maybridge4_004674 COC(=O)[C@@H](NC(=O)c1cc(C)on1)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I15 compound treatment 76360.0 8670.0 0.14 96680.0 -1520.0 -0.02 0.084 0.579 1224162 Maybridge4_004675 CC(C)(C)C(=O)N1CCN(CC1)c2nc3ccc(Cl)cc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I16 compound treatment 89600.0 21900.0 0.36 97000.0 -1200.0 -0.02 0.2422 0.6687 3065852 Maybridge4_004676 CCN(C(=S)Nc1ccc(C)cc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I17 compound treatment 7560.0 -60100.0 -0.99 10240.0 -88000.0 -1.4 -1.6933 -0.9857 3178999 Maybridge4_004677 Clc1ccc(cc1)c2nnc(Sc3nc(ns3)c4cccs4)[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I18 compound treatment 53280.0 -14400.0 -0.24 90600.0 -7600.0 -0.12 -0.2539 -0.951 3065853 Maybridge4_004678 CCCNC(=O)Nc1nc(Nc2ccc(Cl)cc2)n[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I19 compound treatment 87600.0 19900.0 0.33 135160.0 37000.0 0.59 0.6489 0.962 3179000 Maybridge4_004679 FC(F)(F)c1ccncc1C(=O)NC(=N)c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I20 compound treatment 15360.0 -52300.0 -0.86 61040.0 -37200.0 -0.59 -1.0297 -0.983 3179001 Maybridge4_004680 CC(Sc1ccc(C)cc1)C(=O)Nc2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I21 compound treatment 35200.0 -32500.0 -0.54 68440.0 -29800.0 -0.47 -0.7147 -0.9981 3065854 Maybridge4_004681 Sc1nnc(s1)c2cnccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I22 mock treatment 37720.0 -30000.0 -0.49 112120.0 13900.0 0.22 -0.193 -0.3559 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I23 mock treatment 39560.0 -28100.0 -0.46 71760.0 -26400.0 -0.42 -0.6264 -0.9988 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 I24 mock treatment 16440.0 -51300.0 -0.85 48320.0 -49900.0 -0.8 -1.1604 -0.9995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J01 mock treatment 27960.0 -39700.0 -0.66 49160.0 -49000.0 -0.78 -1.0165 -0.9962 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J02 mock treatment 41720.0 -26000.0 -0.43 88720.0 -9480.0 -0.15 -0.41 -0.9019 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J03 mock treatment 40040.0 -27700.0 -0.46 85760.0 -12400.0 -0.2 -0.463 -0.9303 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J04 mock treatment 59560.0 -8130.0 -0.13 109480.0 11300.0 0.18 0.0322 0.1434 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J05 mock treatment 72560.0 4870.0 0.08 112000.0 13800.0 0.22 0.2123 0.9068 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J06 mock treatment 106440.0 38700.0 0.64 129320.0 31100.0 0.5 0.803 0.9921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J07 mock treatment 65720.0 -1970.0 -0.03 123240.0 25000.0 0.4 0.2591 0.6472 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J08 mock treatment 87400.0 19700.0 0.33 109440.0 11200.0 0.18 0.3567 0.9605 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J09 mock treatment 89960.0 22300.0 0.37 130040.0 31800.0 0.51 0.6187 0.9875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J10 mock treatment 97120.0 29400.0 0.49 133800.0 35600.0 0.57 0.7447 0.997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J11 mock treatment 114160.0 46500.0 0.77 123800.0 25600.0 0.41 0.8309 0.9564 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J12 mock treatment 125240.0 57500.0 0.95 136360.0 38200.0 0.61 1.1017 0.9768 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J13 mock treatment 132520.0 64800.0 1.07 132040.0 33800.0 0.54 1.138 0.9497 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J14 mock treatment 102120.0 34400.0 0.57 112440.0 14200.0 0.23 0.5623 0.9189 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J15 mock treatment 76760.0 9070.0 0.15 115040.0 16800.0 0.27 0.2956 0.962 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J16 mock treatment 79120.0 11400.0 0.19 96840.0 -1360.0 -0.02 0.118 0.6216 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J17 mock treatment 52520.0 -15200.0 -0.25 105000.0 6800.0 0.11 -0.1005 -0.3682 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J18 mock treatment 81280.0 13600.0 0.22 105800.0 7600.0 0.12 0.2442 0.9582 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J19 mock treatment 73840.0 6150.0 0.1 124160.0 26000.0 0.41 0.3643 0.8552 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J20 mock treatment 70760.0 3070.0 0.05 110040.0 11800.0 0.19 0.1692 0.8661 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J21 mock treatment 38440.0 -29300.0 -0.48 108360.0 10200.0 0.16 -0.227 -0.4456 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J22 mock treatment 37560.0 -30100.0 -0.5 84120.0 -14100.0 -0.22 -0.5104 -0.9353 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J23 mock treatment 50000.0 -17700.0 -0.29 80920.0 -17300.0 -0.28 -0.4013 -0.9996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 J24 mock treatment 19000.0 -48700.0 -0.8 58360.0 -39800.0 -0.64 -1.0174 -0.9932 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K01 compound treatment 14120.0 -53600.0 -0.88 11160.0 -87000.0 -1.39 -1.6063 -0.9764 3065855 Maybridge4_004682 Oc1c/c(=N\c2ccc(Cl)cc2)/nc(COc3ccccc3)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K02 compound treatment 2520.0 -65200.0 -1.08 3640.0 -94600.0 -1.51 -1.8265 -0.9863 3179002 Maybridge4_004683 Cc1cc(nn1C(C)(C)C)C(=O)Sc2cccc(c2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K03 compound treatment 2720.0 -65000.0 -1.07 4360.0 -93800.0 -1.5 -1.816 -0.9867 3179003 Maybridge4_004684 Cc1noc(COc2ccccc2)c1C(=O)Sc3ccc(F)cc3F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K04 compound treatment 20360.0 -47300.0 -0.78 28240.0 -70000.0 -1.12 -1.341 -0.9849 3065857 Maybridge4_004685 Cc1c(C#N)c(Sc2cccc(c2)C(F)(F)F)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K05 compound treatment 32360.0 -35300.0 -0.58 67320.0 -30900.0 -0.49 -0.7605 -0.9964 3179004 Maybridge4_004686 CSc1nc(CSc2ccc(Cl)cc2)nc(C3CC3)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K06 compound treatment 61880.0 -5810.0 -0.1 115640.0 17400.0 0.28 0.1287 0.4376 3065858 Maybridge4_004687 Cc1cc(nn1Cc2c(Cl)cccc2Cl)C(=O)SCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K07 compound treatment 49320.0 -18400.0 -0.3 60320.0 -37900.0 -0.6 -0.6414 -0.9493 3179005 Maybridge4_004688 CCOC(=O)c1cc(C#N)c(Oc2ccc(C)cc2)nc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K08 compound treatment 5400.0 -62300.0 -1.03 7480.0 -90700.0 -1.45 -1.7496 -0.9861 3065859 Maybridge4_004689 CC(C)OC(=O)Nc1cc(Cl)cc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K09 compound treatment 33520.0 -34200.0 -0.56 25680.0 -72500.0 -1.16 -1.2162 -0.9456 3179006 Maybridge4_004690 FC(F)(F)C1CCN(CC1)c2ncccc2NC(=S)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K10 compound treatment 49800.0 -17900.0 -0.3 36440.0 -61800.0 -0.98 -0.9049 -0.8805 1235731 Maybridge4_004691 S=C(NC1CCCC1)N2CCCN(CC2)c3ccc(C#N)cn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K11 compound treatment 65400.0 -2290.0 -0.04 44640.0 -53600.0 -0.85 -0.6304 -0.7378 3179007 Maybridge4_004692 FC(F)(F)c1ccc(nc1)C(=N)NC(=O)c2cccc(c2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K12 compound treatment 55680.0 -12000.0 -0.2 59320.0 -38900.0 -0.62 -0.5784 -0.889 1285775 Maybridge4_004693 Cc1onc(c1c2csc(CCn3c(=O)oc4ccccc34)n2)c5c(Cl)cccc5Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K13 compound treatment 109520.0 41800.0 0.69 125480.0 27300.0 0.43 0.7956 0.9751 3065861 Maybridge4_004694 NNC(=O)c1cccc(n1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K14 compound treatment 67720.0 25.7 0.0 97600.0 -602.0 -0.01 -0.0065 -0.6751 3179092 Maybridge4_004695 CC(C)(C)OC(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCN3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K15 compound treatment 67800.0 106.0 0.0 112120.0 13900.0 0.22 0.1581 0.7126 3065862 Maybridge4_004696 FC(F)(F)c1ccc(nc1)c2nnc(S)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K16 compound treatment 37200.0 -30500.0 -0.5 89000.0 -9200.0 -0.15 -0.4596 -0.8767 3065863 Maybridge4_004697 CC(C)N(CCC#N)C(=S)Nc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K17 compound treatment 54680.0 -13000.0 -0.21 100080.0 1880.0 0.03 -0.1307 -0.6027 3179093 Maybridge4_004698 CC(C)C(=N)NC(=S)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K18 compound treatment 58240.0 -9450.0 -0.16 109840.0 11600.0 0.19 0.0208 0.0859 1330597 Maybridge4_004699 CS(=O)(=O)c1ccc(cc1)C(=O)Nc2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K19 compound treatment 63040.0 -4650.0 -0.08 112840.0 14600.0 0.23 0.1107 0.4505 3179094 Maybridge4_004700 N=C(NC(=O)N1CCOCC1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K20 compound treatment 46560.0 -21100.0 -0.35 93680.0 -4520.0 -0.07 -0.2976 -0.8355 3065864 Maybridge4_004701 CN(C)/C=N/c1ncc(Br)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K21 compound treatment 34120.0 -33600.0 -0.55 100680.0 2480.0 0.04 -0.364 -0.655 3179095 Maybridge4_004702 CC(C)(C)C(=O)CSc1nnc(s1)c2cnccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K22 mock treatment 32640.0 -35100.0 -0.58 78360.0 -19800.0 -0.32 -0.6328 -0.9596 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K23 mock treatment 34560.0 -33100.0 -0.55 97560.0 -642.0 -0.01 -0.394 -0.7202 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 K24 mock treatment 14000.0 -53700.0 -0.89 29360.0 -68800.0 -1.1 -1.4026 -0.9944 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L01 mock treatment 24280.0 -43400.0 -0.72 33920.0 -64300.0 -1.02 -1.2312 -0.9847 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L02 mock treatment 24960.0 -42700.0 -0.71 45080.0 -53100.0 -0.85 -1.0975 -0.9959 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L03 mock treatment 31240.0 -36500.0 -0.6 57120.0 -41100.0 -0.65 -0.8885 -0.9991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L04 mock treatment 34560.0 -33100.0 -0.55 75600.0 -22600.0 -0.36 -0.6415 -0.9795 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L05 mock treatment 45520.0 -22200.0 -0.37 85080.0 -13100.0 -0.21 -0.4067 -0.9647 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L06 mock treatment 61200.0 -6490.0 -0.11 106480.0 8280.0 0.13 0.0175 0.1029 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L07 mock treatment 45920.0 -21800.0 -0.36 85680.0 -12500.0 -0.2 -0.3953 -0.9615 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L08 mock treatment 62760.0 -4930.0 -0.08 87600.0 -10600.0 -0.17 -0.1771 -0.944 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L09 mock treatment 60400.0 -7290.0 -0.12 93640.0 -4560.0 -0.07 -0.1366 -0.9708 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L10 mock treatment 65080.0 -2610.0 -0.04 111240.0 13000.0 0.21 0.1164 0.5486 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L11 mock treatment 78640.0 10900.0 0.18 95960.0 -2240.0 -0.04 0.1025 0.5565 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L12 mock treatment 108640.0 40900.0 0.68 133400.0 35200.0 0.56 0.8746 0.9957 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L13 mock treatment 126200.0 58500.0 0.97 126680.0 28500.0 0.45 1.0039 0.9407 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L14 mock treatment 75120.0 7430.0 0.12 103680.0 5480.0 0.09 0.1484 0.9862 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L15 mock treatment 51560.0 -16100.0 -0.27 91280.0 -6920.0 -0.11 -0.2663 -0.9239 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L16 mock treatment 38960.0 -28700.0 -0.47 82400.0 -15800.0 -0.25 -0.5135 -0.9561 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L17 mock treatment 27120.0 -40600.0 -0.67 90520.0 -7680.0 -0.12 -0.5602 -0.8227 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L18 mock treatment 38880.0 -28800.0 -0.48 92080.0 -6120.0 -0.1 -0.4053 -0.8348 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L19 mock treatment 48440.0 -19300.0 -0.32 88880.0 -9320.0 -0.15 -0.3298 -0.94 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L20 mock treatment 43280.0 -24400.0 -0.4 109120.0 10900.0 0.17 -0.1619 -0.3689 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L21 mock treatment 31000.0 -36700.0 -0.61 87120.0 -11100.0 -0.18 -0.5532 -0.8768 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L22 mock treatment 23360.0 -44300.0 -0.73 67840.0 -30400.0 -0.48 -0.8597 -0.9798 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L23 mock treatment 24520.0 -43200.0 -0.71 47160.0 -51000.0 -0.81 -1.0792 -0.9978 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 L24 mock treatment 21240.0 -46500.0 -0.77 40080.0 -58100.0 -0.93 -1.1973 -0.9956 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M01 compound treatment 24120.0 -43600.0 -0.72 19360.0 -78800.0 -1.26 -1.3972 -0.965 3065865 Maybridge4_004703 FC(F)(F)c1cccn(CCc2nc(cs2)c3ccccc3)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M02 compound treatment 2520.0 -65200.0 -1.08 2720.0 -95500.0 -1.52 -1.8368 -0.9856 3179096 Maybridge4_004704 Cc1cc(nn1C(C)(C)C)C(=O)Sc2cccc(Br)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M03 compound treatment 27160.0 -40500.0 -0.67 6920.0 -91300.0 -1.45 -1.5019 -0.9379 3179097 Maybridge4_004705 CN(CCOC(=O)c1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M04 compound treatment 29480.0 -38200.0 -0.63 40640.0 -57600.0 -0.92 -1.0948 -0.9833 3065866 Maybridge4_004706 Cc1c(C#N)c(Sc2n[nH]c(=O)n2C3CCCCC3)nc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M05 compound treatment 23520.0 -44200.0 -0.73 91960.0 -6240.0 -0.1 -0.586 -0.7962 3065894 Maybridge4_004707 CCOC(=O)c1cc(C)nc(Sc2ccccc2NC(=O)c3cccc(c3)C(F)(F)F)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M06 compound treatment 30280.0 -37400.0 -0.62 89440.0 -8760.0 -0.14 -0.5355 -0.8456 3065895 Maybridge4_004708 OC(C(O)c1nc2cc(C#N)ccc2[nH]1)c3nc4cc(C#N)ccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M07 compound treatment 10480.0 -57200.0 -0.94 16600.0 -81600.0 -1.3 -1.5875 -0.9876 3065896 Maybridge4_004709 CCOC(=O)c1cc(C#N)c(Sc2nnc([nH]2)C(C)(C)C)nc1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M08 compound treatment 31960.0 -35700.0 -0.59 23400.0 -74800.0 -1.19 -1.2601 -0.9473 3065897 Maybridge4_004710 NC(=S)Cc1ccc(Cl)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M09 compound treatment 21720.0 -46000.0 -0.76 8920.0 -89300.0 -1.42 -1.5429 -0.9567 3065898 Maybridge4_004711 FC(F)(F)C1CCN(CC1)c2ncccc2NC(=S)Nc3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M10 compound treatment 32880.0 -34800.0 -0.57 16680.0 -81500.0 -1.3 -1.3251 -0.9327 1643927 Maybridge4_004712 CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)c2nnc(S)n2CC3CCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M11 compound treatment 51680.0 -16000.0 -0.26 51480.0 -46700.0 -0.74 -0.7135 -0.9029 3065900 Maybridge4_004713 FC(F)(F)c1ccc(=O)n(Cc2cccc(C#N)c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M12 compound treatment 81880.0 14200.0 0.23 69040.0 -29200.0 -0.46 -0.1631 -0.3133 1263587 Maybridge4_004714 COc1ccccc1OCc2nc(cs2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M13 compound treatment 77520.0 9830.0 0.16 114920.0 16700.0 0.27 0.3031 0.9717 3179098 Maybridge4_004715 FC(F)(F)c1ccc(cc1)C(=N)NC(=O)CCn2c(=O)oc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M14 compound treatment 48200.0 -19500.0 -0.32 75840.0 -22400.0 -0.36 -0.4796 -0.9987 1136340 Maybridge4_004716 CCOc1cc(N2CCOCC2)c(OCC)cc1NS(=O)(=O)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M15 compound treatment 53480.0 -14200.0 -0.23 113320.0 15100.0 0.24 0.0045 0.0133 3179099 Maybridge4_004717 FC(F)(F)c1ccc(nc1)c2nnc(SCC=C)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M16 compound treatment 32680.0 -35000.0 -0.58 71760.0 -26400.0 -0.42 -0.7067 -0.988 1122167 Maybridge4_004718 O=C(N1CCN(CCOc2ccccc2)CC1)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M17 compound treatment 3080.0 -64600.0 -1.07 8920.0 -89300.0 -1.42 -1.7604 -0.9899 3179100 Maybridge4_004719 FC(F)(F)COc1ccc(cn1)C(=O)NC(=N)c2ccc(cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M18 compound treatment 22800.0 -44900.0 -0.74 89600.0 -8600.0 -0.14 -0.621 -0.8239 3065901 Maybridge4_004720 CNC(=O)Nc1nc2cccnc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M19 compound treatment 32280.0 -35400.0 -0.58 118960.0 20800.0 0.33 -0.1794 -0.2671 1030287 Maybridge4_004721 CSc1nc(O)cc(O)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M20 compound treatment 18600.0 -49100.0 -0.81 39760.0 -58400.0 -0.93 -1.2317 -0.9976 3179101 Maybridge4_004722 Cc1nc(N/C=N/O)c(Br)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M21 compound treatment 22680.0 -45000.0 -0.74 38360.0 -59800.0 -0.95 -1.1999 -0.9924 3179102 Maybridge4_004723 Cc1nc(c(s1)C(=O)Sc2ccc(C)cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M22 mock treatment 19600.0 -48100.0 -0.79 64120.0 -34100.0 -0.54 -0.9455 -0.9829 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M23 mock treatment 32000.0 -35700.0 -0.59 64240.0 -34000.0 -0.54 -0.7994 -0.9991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 M24 mock treatment 22160.0 -45500.0 -0.75 31160.0 -67000.0 -1.07 -1.2871 -0.9852 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N01 mock treatment 26320.0 -41400.0 -0.68 35440.0 -62800.0 -1.0 -1.1903 -0.9827 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N02 mock treatment 29440.0 -38300.0 -0.63 37240.0 -61000.0 -0.97 -1.1336 -0.9782 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N03 mock treatment 20240.0 -47500.0 -0.78 40040.0 -58200.0 -0.93 -1.2094 -0.9965 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N04 mock treatment 29960.0 -37700.0 -0.62 43520.0 -54700.0 -0.87 -1.0567 -0.9864 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N05 mock treatment 30600.0 -37100.0 -0.61 64840.0 -33400.0 -0.53 -0.809 -0.9975 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N06 mock treatment 26560.0 -41100.0 -0.68 76040.0 -22200.0 -0.35 -0.7299 -0.9536 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N07 mock treatment 21480.0 -46200.0 -0.76 43200.0 -55000.0 -0.88 -1.1593 -0.9976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N08 mock treatment 32400.0 -35300.0 -0.58 69920.0 -28300.0 -0.45 -0.7307 -0.992 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N09 mock treatment 23640.0 -44100.0 -0.73 87760.0 -10400.0 -0.17 -0.6319 -0.847 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N10 mock treatment 35080.0 -32600.0 -0.54 74800.0 -23400.0 -0.37 -0.6444 -0.9839 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N11 mock treatment 44720.0 -23000.0 -0.38 82560.0 -15600.0 -0.25 -0.4444 -0.9793 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N12 mock treatment 109640.0 41900.0 0.69 113720.0 15500.0 0.25 0.6645 0.9038 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N13 mock treatment 92560.0 24900.0 0.41 118440.0 20200.0 0.32 0.5183 0.9929 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N14 mock treatment 49440.0 -18300.0 -0.3 99280.0 1080.0 0.02 -0.2009 -0.6657 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N15 mock treatment 42800.0 -24900.0 -0.41 75520.0 -22700.0 -0.36 -0.5462 -0.998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N16 mock treatment 21080.0 -46600.0 -0.77 58440.0 -39800.0 -0.63 -0.9922 -0.9954 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N17 mock treatment 26840.0 -40900.0 -0.67 52280.0 -45900.0 -0.73 -0.9944 -0.9992 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N18 mock treatment 21240.0 -46500.0 -0.77 52200.0 -46000.0 -0.73 -1.0607 -0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N19 mock treatment 31800.0 -35900.0 -0.59 48840.0 -49400.0 -0.79 -0.9753 -0.9902 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N20 mock treatment 30320.0 -37400.0 -0.62 50480.0 -47700.0 -0.76 -0.9741 -0.9946 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N21 mock treatment 25400.0 -42300.0 -0.7 57080.0 -41100.0 -0.66 -0.9571 -0.9995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N22 mock treatment 19720.0 -48000.0 -0.79 43360.0 -54800.0 -0.87 -1.1781 -0.9988 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N23 mock treatment 17320.0 -50400.0 -0.83 44600.0 -53600.0 -0.85 -1.1921 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 N24 mock treatment 21120.0 -46600.0 -0.77 44800.0 -53400.0 -0.85 -1.1455 -0.9987 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O01 compound treatment 35000.0 -32700.0 -0.54 20840.0 -77400.0 -1.23 -1.2535 -0.9313 3065902 Maybridge4_004724 Cc1nn(c(N)c1C(=S)N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O02 compound treatment 32680.0 -35000.0 -0.58 6240.0 -92000.0 -1.47 -1.4451 -0.9172 1470895 Maybridge4_004725 CCOC(=O)c1cc(Sc2ccccc2NC(=O)c3ccccc3)cc(n1)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O03 compound treatment 25720.0 -42000.0 -0.69 3560.0 -94600.0 -1.51 -1.5566 -0.9377 3065903 Maybridge4_004726 Cc1cc(no1)c2nnc(SCC(=O)c3ccccc3Cl)n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O04 compound treatment 11600.0 -56100.0 -0.93 9960.0 -88200.0 -1.41 -1.6493 -0.9794 1417512 Maybridge4_004727 Cc1c(C#N)c(Sc2ccccc2NC(=O)c3ccccc3)nc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O05 compound treatment 2040.0 -65700.0 -1.08 3360.0 -94800.0 -1.51 -1.8352 -0.9867 3065905 Maybridge4_004728 CC(C)(C)c1ccc(OCC(=N)NC(=O)c2ccc(OC(F)(F)F)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O06 compound treatment 14600.0 -53100.0 -0.88 24760.0 -73400.0 -1.17 -1.4474 -0.9898 1176898 Maybridge4_004729 OC(C(O)c1nc2cc(Cl)ccc2[nH]1)c3nc4cc(Cl)ccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O07 compound treatment 16680.0 -51000.0 -0.84 20560.0 -77600.0 -1.24 -1.4705 -0.9824 3065906 Maybridge4_004730 Cc1nc(nc(Sc2nnc([nH]2)c3cccs3)c1C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O08 compound treatment 15720.0 -52000.0 -0.86 9440.0 -88800.0 -1.41 -1.607 -0.9713 3179103 Maybridge4_004731 CC(=O)N/C(=C\c1ccc2ccccc2c1)/C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O09 compound treatment 22200.0 -45500.0 -0.75 9280.0 -88900.0 -1.42 -1.5332 -0.9559 3179104 Maybridge4_004732 NC(=O)C1=CN(Cc2ccccc2)CCC1C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O10 compound treatment 3880.0 -63800.0 -1.05 4120.0 -94100.0 -1.5 -1.8052 -0.9851 3065908 Maybridge4_004733 CC(C)(C)c1cc(c2nnc(o2)c3cccs3)n(Cc4ccc(F)cc4)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O11 compound treatment 33200.0 -34500.0 -0.57 28000.0 -70200.0 -1.12 -1.1938 -0.9509 3179105 Maybridge4_004734 FC(F)(F)COc1cc(cc(OCC(F)(F)F)n1)c2nnc(S)n2Cc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O12 compound treatment 5200.0 -62500.0 -1.03 6320.0 -91900.0 -1.46 -1.765 -0.9853 3065960 Maybridge4_004735 Clc1ccc(Sc2c[nH]nc2c3ccc4OCCOc4c3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O13 compound treatment 81400.0 13700.0 0.23 98440.0 238.0 0.0 0.1627 0.7189 1741446 Maybridge4_004736 CC(C)(C)NC(=O)N1CCN(CC1)c2ccc(C#N)cn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O14 compound treatment 41920.0 -25800.0 -0.43 57000.0 -41200.0 -0.66 -0.7652 -0.9779 1571449 Maybridge4_004737 CCOc1cc(N2CCOCC2)c(OCC)cc1NC(=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O15 compound treatment 28200.0 -39500.0 -0.65 55640.0 -42600.0 -0.68 -0.9407 -0.9998 3065932 Maybridge4_004738 N/C(=N\O)/c1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O16 compound treatment 3000.0 -64700.0 -1.07 5320.0 -92900.0 -1.48 -1.8019 -0.9872 1468379 Maybridge4_004739 CC(C)c1ccc(NC(=O)N2CCCN(CCOc3ccccc3)CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O17 compound treatment 2400.0 -65300.0 -1.08 4480.0 -93700.0 -1.49 -1.8184 -0.9872 3065933 Maybridge4_004740 COc1ccc(OCC(=N)NC(=S)Nc2cccc(c2)C(F)(F)F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O18 compound treatment 25640.0 -42100.0 -0.69 38240.0 -60000.0 -0.96 -1.1667 -0.9877 3065934 Maybridge4_004741 NC(=C(C#N)C#N)Nc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O19 compound treatment 23640.0 -44100.0 -0.73 53080.0 -45100.0 -0.72 -1.0227 -1.0 3065935 Maybridge4_004742 Oc1nnc(SCC(=O)N2CCC(CC2)C(F)(F)F)n1c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O20 compound treatment 29440.0 -38300.0 -0.63 44680.0 -53500.0 -0.85 -1.0497 -0.989 3065936 Maybridge4_004743 Cc1cc(Br)cnc1N/C=N/O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O21 compound treatment 19280.0 -48400.0 -0.8 33800.0 -64400.0 -1.03 -1.2909 -0.9923 3179106 Maybridge4_004744 Cc1nc(c(s1)C(=O)Sc2cccc(c2)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O22 mock treatment 29120.0 -38600.0 -0.64 59640.0 -38600.0 -0.61 -0.8849 -0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O23 mock treatment 27320.0 -40400.0 -0.67 70560.0 -27600.0 -0.44 -0.7828 -0.9798 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 O24 mock treatment 40920.0 -26800.0 -0.44 49360.0 -48800.0 -0.78 -0.863 -0.964 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P01 mock treatment 49920.0 -17800.0 -0.29 67560.0 -30600.0 -0.49 -0.5528 -0.9703 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P02 mock treatment 55240.0 -12500.0 -0.21 46720.0 -51500.0 -0.82 -0.7256 -0.8578 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P03 mock treatment 54760.0 -12900.0 -0.21 34920.0 -63300.0 -1.01 -0.8642 -0.8382 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P04 mock treatment 47040.0 -20700.0 -0.34 42480.0 -55700.0 -0.89 -0.8691 -0.9136 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P05 mock treatment 39080.0 -28600.0 -0.47 41560.0 -56600.0 -0.9 -0.9724 -0.9543 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P06 mock treatment 20040.0 -47700.0 -0.79 29880.0 -68300.0 -1.09 -1.3262 -0.9873 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P07 mock treatment 27240.0 -40500.0 -0.67 32560.0 -65600.0 -1.05 -1.212 -0.9765 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P08 mock treatment 31680.0 -36000.0 -0.59 39120.0 -59100.0 -0.94 -1.0862 -0.9754 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P09 mock treatment 28800.0 -38900.0 -0.64 26720.0 -71500.0 -1.14 -1.2596 -0.9632 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P10 mock treatment 26360.0 -41300.0 -0.68 36160.0 -62000.0 -0.99 -1.1817 -0.9836 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P11 mock treatment 32840.0 -34900.0 -0.58 39600.0 -58600.0 -0.93 -1.0673 -0.9729 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P12 mock treatment 57560.0 -10100.0 -0.17 74520.0 -23700.0 -0.38 -0.3852 -0.933 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P13 mock treatment 48480.0 -19200.0 -0.32 79880.0 -18300.0 -0.29 -0.4308 -0.9991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P14 mock treatment 47200.0 -20500.0 -0.34 74080.0 -24100.0 -0.38 -0.5111 -0.998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P15 mock treatment 39760.0 -27900.0 -0.46 54800.0 -43400.0 -0.69 -0.8152 -0.9806 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P16 mock treatment 35840.0 -31900.0 -0.53 37720.0 -60500.0 -0.96 -1.0535 -0.9594 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P17 mock treatment 32760.0 -34900.0 -0.58 44720.0 -53500.0 -0.85 -1.0105 -0.9819 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P18 mock treatment 25160.0 -42500.0 -0.7 36840.0 -61400.0 -0.98 -1.188 -0.9868 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P19 mock treatment 38600.0 -29100.0 -0.48 39280.0 -58900.0 -0.94 -1.0037 -0.9515 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P20 mock treatment 38920.0 -28800.0 -0.47 43080.0 -55100.0 -0.88 -0.9571 -0.9583 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P21 mock treatment 34200.0 -33500.0 -0.55 44720.0 -53500.0 -0.85 -0.9937 -0.978 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P22 mock treatment 51400.0 -16300.0 -0.27 49440.0 -48800.0 -0.78 -0.7397 -0.8995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P23 mock treatment 43600.0 -24100.0 -0.4 40520.0 -57700.0 -0.92 -0.9313 -0.9297 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2062 P24 mock treatment 45360.0 -22300.0 -0.37 60360.0 -37800.0 -0.6 -0.6872 -0.9721 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A01 compound treatment 18320.0 -66900.0 -1.1 20640.0 -70900.0 -1.13 -1.5803 -0.9999 1360118 TimTec1_000001 CC1=C(C(C2=C(CC(CC2=O)c3ccccc3)N1)c4ccncc4)C(=O)OC5CCCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A02 compound treatment 91400.0 6180.0 0.1 90000.0 -1570.0 -0.03 0.0544 0.5181 1352805 TimTec1_000002 CCOC(=O)c1cc2ccccc2oc1=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A03 compound treatment 47520.0 -37700.0 -0.62 35440.0 -56100.0 -0.89 -1.0727 -0.9843 1269647 TimTec1_000003 CN1C2CCC1CC(C2)NC3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A04 compound treatment 20120.0 -65100.0 -1.07 12240.0 -79300.0 -1.26 -1.654 -0.9967 1717432 TimTec1_000004 NC1=C(C#N)C2=C(CCCC2)C(c3ccccc3)C1(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A05 compound treatment 184360.0 99100.0 1.64 101320.0 9750.0 0.16 1.267 0.7708 1640292 TimTec1_000005 CC1C2CC(C(C2=O)S(=O)(=O)N3CCOCC3)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A06 compound treatment 160800.0 75600.0 1.25 65680.0 -25900.0 -0.41 0.5904 0.4493 1432692 TimTec1_000006 CC(=C)C[N+](C)(C)Cc1c(C)ccc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A07 compound treatment 119680.0 34500.0 0.57 30240.0 -61300.0 -0.98 -0.289 -0.2555 3209477 TimTec1_000007 O=C1N(CSc2nc3ccccc3s2)C(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A08 compound treatment 171800.0 86600.0 1.43 55880.0 -35700.0 -0.57 0.6083 0.3955 1665724 TimTec1_000008 CC1(C)CC(=C(C(C2C(=O)CC(C)(C)CC2=O)c3ccccc3)C(=O)C1)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A09 compound treatment 188000.0 103000.0 1.7 56520.0 -35100.0 -0.56 0.8046 0.4505 1568897 TimTec1_000009 CCOC(=O)c1ccc(NC(=O)NC2OC(CO)C(O)C(O)C2O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A10 compound treatment 187280.0 102000.0 1.68 42520.0 -49100.0 -0.78 0.6384 0.3438 3082080 TimTec1_000010 Cc1cc[n+](Cc2ccccn2)c(N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A11 compound treatment 197560.0 112000.0 1.85 63360.0 -28200.0 -0.45 0.9933 0.5206 1782663 TimTec1_000011 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3NC2/C=C/c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A12 compound treatment 202320.0 117000.0 1.93 82600.0 -8970.0 -0.14 1.2657 0.653 3082082 TimTec1_000012 CCCC1CCCCCC1NC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A13 compound treatment 219720.0 134000.0 2.22 111960.0 20400.0 0.32 1.7997 0.8021 3508726 TimTec1_000013 CCC(=O)NC1CC(CC=C1C)C(C)(C)NC(=O)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A14 compound treatment 166480.0 81300.0 1.34 72200.0 -19400.0 -0.31 0.7302 0.5305 3209587 TimTec1_000014 OC(=O)CCC(=O)N=S(c1ccccc1)c2ccccc2.Oc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A15 compound treatment 177040.0 91800.0 1.52 61040.0 -30500.0 -0.49 0.7276 0.4571 1459520 TimTec1_000015 COc1ccccc1c2nnc(N)[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A16 compound treatment 11200.0 -74000.0 -1.22 4000.0 -87600.0 -1.4 -1.851 -0.9978 3082084 TimTec1_000016 Cc1[nH]c2ccccc2c1Sc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A17 compound treatment 160080.0 74900.0 1.24 52080.0 -39500.0 -0.63 0.4287 0.3091 1172294 TimTec1_000017 Cc1cc(C)c(NC(=O)CCNC2CCCCC2)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A18 compound treatment 88040.0 2820.0 0.05 42920.0 -48700.0 -0.78 -0.5154 -0.6635 1183562 TimTec1_000018 CCOC(=O)c1c(CN2CCOCC2)n(c3ccccc3)c4ccc(O)cc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A19 compound treatment 43400.0 -41800.0 -0.69 32000.0 -59600.0 -0.95 -1.1595 -0.9877 1230606 TimTec1_000019 CCN1CCN(CC1)c2ccc(NC(=O)c3cccc(Br)c3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A20 compound treatment 121680.0 36500.0 0.6 59040.0 -32500.0 -0.52 0.0589 0.0742 1045901 TimTec1_000020 COC(=O)c1cc2ccccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A21 compound treatment 11760.0 -73500.0 -1.21 6160.0 -85400.0 -1.36 -1.8201 -0.9983 3209588 TimTec1_000021 CSc1ccc(/C=N/n2nnnc2Nc3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A22 compound treatment 43600.0 -41600.0 -0.69 40520.0 -51100.0 -0.81 -1.0612 -0.9965 3082088 TimTec1_000022 OC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A23 mock treatment 93880.0 8660.0 0.14 76200.0 -15400.0 -0.24 -0.0722 -0.2545 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 A24 mock treatment 54240.0 -31000.0 -0.51 96080.0 4510.0 0.07 -0.3108 -0.6018 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B01 compound treatment 39160.0 -46100.0 -0.76 38720.0 -52900.0 -0.84 -1.1333 -0.9987 1462495 TimTec1_000023 CSc1c(CC(=O)Nc2ccccc2)n(C)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B02 compound treatment 8280.0 -76900.0 -1.27 13280.0 -78300.0 -1.25 -1.7805 -1.0 3209589 TimTec1_000024 Nc1c(sc2nc(N)c(C#N)cc12)C(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B03 compound treatment 156840.0 71600.0 1.18 91960.0 389.0 0.01 0.8403 0.7108 1291339 TimTec1_000025 CCOC(=O)c1c(CN2CCOCC2)n(C)c3ccc(O)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B04 compound treatment 135880.0 50700.0 0.84 50280.0 -41300.0 -0.66 0.1259 0.1183 1292419 TimTec1_000026 O=C(Oc1ccc(OC(=O)c2ccco2)cc1)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B05 compound treatment 195880.0 111000.0 1.83 113400.0 21800.0 0.35 1.5377 0.8269 1346277 TimTec1_000027 O=C(N1CCCCC1)c2ccc(cc2)C(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B06 compound treatment 189560.0 104000.0 1.72 120160.0 28600.0 0.46 1.5401 0.8644 1037513 TimTec1_000028 O=C1N(C(=O)c2ccccc12)c3nccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B07 compound treatment 177160.0 91900.0 1.52 63840.0 -27700.0 -0.44 0.7606 0.4812 3209590 TimTec1_000029 Cc1ccc(s1)C(=O)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B08 compound treatment 178080.0 92900.0 1.53 67480.0 -24100.0 -0.38 0.8124 0.5141 1598558 TimTec1_000030 O=C(Nc1ccccc1)C(=S)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B09 compound treatment 45800.0 -39400.0 -0.65 8600.0 -83000.0 -1.32 -1.3953 -0.9467 1166367 TimTec1_000031 CCOC(=O)c1c(CN2CCCCC2)n(c3ccccc3)c4cc(Br)c(OC)cc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B10 compound treatment 113320.0 28100.0 0.46 40720.0 -50900.0 -0.81 -0.2451 -0.2625 3081103 TimTec1_000032 C/C(=N\C1CC1)/c2c(C)[nH]n(c3nc4ccccc4s3)c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B11 compound treatment 115200.0 30000.0 0.49 49480.0 -42100.0 -0.67 -0.1245 -0.1493 1692568 TimTec1_000033 Fc1ccc(cc1)C(=O)CCCN2CCNCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B12 compound treatment 119480.0 34300.0 0.57 74320.0 -17300.0 -0.27 0.2054 0.3267 3209591 TimTec1_000034 CCN1C(=O)/C(=C\2/C=Cc3ccccc3N2CC)/N(C)C1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B13 compound treatment 86080.0 858.0 0.01 41680.0 -49900.0 -0.8 -0.5523 -0.6944 1611433 TimTec1_000035 CC(=O)Oc1ccc2occ(C(=O)c3ccc(Br)s3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B14 compound treatment 29720.0 -55500.0 -0.92 18000.0 -73600.0 -1.17 -1.477 -0.9925 1351179 TimTec1_000036 O=C(c1nnn(c1Nc2ccccc2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B15 compound treatment 217280.0 132000.0 2.18 89880.0 -1690.0 -0.03 1.5224 0.6983 1357665 TimTec1_000037 OC(=O)c1cccc(CN2CCN(CC2)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B16 compound treatment 209560.0 124000.0 2.05 71320.0 -20300.0 -0.32 1.2231 0.5887 1209399 TimTec1_000038 O=C(NCCc1ccccc1)c2ccc(cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B17 compound treatment 193320.0 108000.0 1.78 78640.0 -12900.0 -0.21 1.116 0.6213 3209592 TimTec1_000039 CNC(=O)CSCc1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B18 compound treatment 12080.0 -73100.0 -1.21 4880.0 -86700.0 -1.38 -1.8308 -0.9977 3209593 TimTec1_000040 O=C(Oc1nc2ccccc2s1)/C=C/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B19 compound treatment 118560.0 33300.0 0.55 72320.0 -19300.0 -0.31 0.1722 0.2732 1421610 TimTec1_000041 CN(C(=O)Oc1cccc(c1)C(=O)Nc2ccc(C)c(C)c2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B20 compound treatment 156560.0 71300.0 1.18 73600.0 -18000.0 -0.29 0.6301 0.52 3209594 TimTec1_000042 COC(=O)NC(Nc1cccc(c1)C(F)(F)F)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B21 compound treatment 141440.0 56200.0 0.93 80040.0 -11500.0 -0.18 0.5262 0.5563 1920491 TimTec1_000043 COc1ccc2nc(NC(=N)N)nc(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B22 compound treatment 32960.0 -52300.0 -0.86 16320.0 -75300.0 -1.2 -1.4581 -0.9869 1644751 TimTec1_000044 COc1ccc(cc1)C(=O)Oc2csc(=S)n2C(=O)c3ccc(OC)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B23 mock treatment 145360.0 60100.0 0.99 91320.0 -251.0 0.0 0.6991 0.7042 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 B24 mock treatment 99840.0 14600.0 0.24 98680.0 7110.0 0.11 0.2507 0.9406 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C01 compound treatment 93920.0 8700.0 0.14 61000.0 -30600.0 -0.49 -0.243 -0.4784 1157703 TimTec1_000045 COc1ccc2C3CC(=Nc4ccccc4N3C(=O)c2c1OC)c5ccc(Br)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C02 compound treatment 159920.0 74700.0 1.23 69960.0 -21600.0 -0.34 0.6283 0.4908 3209595 TimTec1_000046 COC(=O)CC1=CC(C)(CC(=O)OC)C(C#N)(C#N)C(=C1C#N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C03 compound treatment 121120.0 35900.0 0.59 70920.0 -20700.0 -0.33 0.1863 0.2748 1704164 TimTec1_000047 CCCCN(C1CC2CCC(C1)N2C)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C04 compound treatment 61600.0 -23600.0 -0.39 40760.0 -50800.0 -0.81 -0.8484 -0.9439 1258841 TimTec1_000048 O=C1C(=C2CCCCC2C(c3ccco3)C1(C#N)C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C05 compound treatment 151560.0 66300.0 1.1 112000.0 20400.0 0.33 1.0046 0.8793 1916777 TimTec1_000049 CC1C/2CC(C(\C2=N\O)S(=O)(=O)N3CCOCC3)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C06 compound treatment 151080.0 65900.0 1.09 89920.0 -1650.0 -0.03 0.7501 0.6898 3209596 TimTec1_000050 COC1OC(COC(=O)C)C(OC(=O)C)C(C#N)(C#N)C1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C07 compound treatment 14800.0 -70400.0 -1.16 5440.0 -86100.0 -1.37 -1.7927 -0.9966 1250478 TimTec1_000051 OC(COc1ccc(Nc2ccccc2)cc1)COc3ccc(Nc4ccccc4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C08 compound treatment 166720.0 81500.0 1.35 47840.0 -43700.0 -0.7 0.4584 0.3026 1606069 TimTec1_000052 CC(C)C(C1C(=O)CC(C)(C)CC1=O)C2=C(O)CC(C)(C)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C09 compound treatment 180600.0 95400.0 1.57 64960.0 -26600.0 -0.42 0.8134 0.4988 3081440 TimTec1_000053 CCNC(=O)c1ccc(Cl)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C10 compound treatment 172200.0 87000.0 1.44 64360.0 -27200.0 -0.43 0.7086 0.4724 3209597 TimTec1_000054 Cc1cc[n+](CCOc2ccc(N)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C11 compound treatment 132680.0 47500.0 0.78 25480.0 -66100.0 -1.05 -0.1909 -0.1454 1677737 TimTec1_000055 CCCCC(=O)N1C(C)CC(Nc2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C12 compound treatment 158160.0 72900.0 1.2 134560.0 43000.0 0.69 1.3358 0.9643 3081441 TimTec1_000056 CCOC(=O)CCCc1ccc(/C=C/C(=O)O)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C13 compound treatment 169120.0 83900.0 1.38 147880.0 56300.0 0.9 1.6139 0.9779 3081442 TimTec1_000057 COC(=O)c1nsc(Cl)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C14 compound treatment 147920.0 62700.0 1.03 105560.0 14000.0 0.22 0.8895 0.8402 1003566 TimTec1_000058 S=C(Nc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C15 compound treatment 135120.0 49900.0 0.82 51560.0 -40000.0 -0.64 0.1315 0.1262 1060631 TimTec1_000059 COC(=O)C1=NNC(C1)(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C16 compound treatment 139400.0 54200.0 0.89 54240.0 -37300.0 -0.6 0.2116 0.197 3081443 TimTec1_000060 CN(C)/C=C(\C=[N+](C)C)/c1n[nH]cc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C17 compound treatment 141120.0 55900.0 0.92 60960.0 -30600.0 -0.49 0.3075 0.2946 1149044 TimTec1_000061 Cc1cc(Cl)c(C(=O)N)c(C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C18 compound treatment 118600.0 33400.0 0.55 42480.0 -49100.0 -0.78 -0.1637 -0.171 1602135 TimTec1_000062 CN1CCc2c(C1)c3cc(C)ccc3n2CCc4ccncc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C19 compound treatment 36800.0 -48400.0 -0.8 27400.0 -64200.0 -1.02 -1.2884 -0.9926 3081444 TimTec1_000063 CCN1CCN(CC1)c2ccc(NC(=O)/C=C/c3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C20 compound treatment 140760.0 55500.0 0.92 88720.0 -2850.0 -0.05 0.6161 0.6712 1241763 TimTec1_000064 Oc1ccc2occ(C(=O)c3cccs3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C21 compound treatment 72640.0 -12600.0 -0.21 40720.0 -50900.0 -0.81 -0.72 -0.8605 3081445 TimTec1_000065 Nc1nnnn1/N=C\2/C(=O)Nc3ccc(Br)cc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C22 compound treatment 6280.0 -78900.0 -1.3 4360.0 -87200.0 -1.39 -1.9043 -0.9995 1336111 TimTec1_000066 COC(=O)CCc1[nH]c2ccccc2c1Sc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C23 mock treatment 123560.0 38300.0 0.63 96880.0 5310.0 0.08 0.5073 0.7946 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 C24 mock treatment 108160.0 22900.0 0.38 107760.0 16200.0 0.26 0.4502 0.9825 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D01 compound treatment 7560.0 -77700.0 -1.28 3600.0 -88000.0 -1.4 -1.898 -0.999 1420975 TimTec1_000067 CSc1c(CC(=O)Nc2ccc(C)cc2)[nH]c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D02 compound treatment 89400.0 4180.0 0.07 56400.0 -35200.0 -0.56 -0.3476 -0.6155 3209598 TimTec1_000068 OC(=O)CCCC=C(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D03 compound treatment 75400.0 -9820.0 -0.16 72880.0 -18700.0 -0.3 -0.3253 -0.9591 3209599 TimTec1_000069 Cc1[nH]c2ccccc2c1/C=N/CCc3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D04 compound treatment 119760.0 34500.0 0.57 79920.0 -11700.0 -0.19 0.2718 0.4533 3081446 TimTec1_000070 Brc1ccc(OC(=O)c2ccco2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D05 compound treatment 146360.0 61100.0 1.01 115520.0 23900.0 0.38 0.9835 0.9115 3081447 TimTec1_000071 CCC(=O)n1c(SC)nc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D06 compound treatment 160480.0 75300.0 1.24 137920.0 46300.0 0.74 1.4008 0.9692 3209600 TimTec1_000072 Nc1nc(SCC(=O)NC2CCCCC2)c(C#N)cc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D07 compound treatment 148240.0 63000.0 1.04 76760.0 -14800.0 -0.24 0.5686 0.5331 3081448 TimTec1_000073 CCCc1ccc(s1)/C(=N/O)/C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D08 compound treatment 28640.0 -56600.0 -0.93 14280.0 -77300.0 -1.23 -1.5315 -0.9907 3209601 TimTec1_000074 CCOC(=O)CCSc1ccccn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D09 compound treatment 43120.0 -42100.0 -0.69 9520.0 -82100.0 -1.31 -1.4162 -0.9562 1380002 TimTec1_000075 CCOC(=O)c1c(CN(C)C)n(c2ccccc2)c3cc(Br)c(OC)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D10 compound treatment 75120.0 -10100.0 -0.17 42320.0 -49300.0 -0.78 -0.673 -0.8386 3081452 TimTec1_000076 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccc(Cl)cc4Cl)C(=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D11 compound treatment 127520.0 42300.0 0.7 89720.0 -1850.0 -0.03 0.4728 0.6766 1674072 TimTec1_000077 Cn1c(CC(=O)O)c(c2ccccc12)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D12 compound treatment 109760.0 24500.0 0.41 98360.0 6790.0 0.11 0.3629 0.8656 1452087 TimTec1_000078 CCSc1nnc-2c(OC(Nc3ccccc32)C(=O)c4ccccc4)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D13 compound treatment 42960.0 -42300.0 -0.7 35920.0 -55700.0 -0.89 -1.1205 -0.9929 1648799 TimTec1_000079 C(CN1CCN(CCSc2ccccc2)CC1)Sc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D14 compound treatment 25320.0 -59900.0 -0.99 14960.0 -76600.0 -1.22 -1.5626 -0.9945 1276972 TimTec1_000080 Clc1ccccc1CN(Cc2cccnc2)C(=S)NC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D15 compound treatment 108800.0 23600.0 0.39 54120.0 -37500.0 -0.6 -0.1469 -0.2061 1186617 TimTec1_000081 Cc1c([nH]c2ccc(OCc3ccccc3)cc12)C(=O)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D16 compound treatment 10880.0 -74300.0 -1.23 5400.0 -86200.0 -1.37 -1.8389 -0.9984 1357113 TimTec1_000082 CC1Oc2ccccc2OC1(O)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D17 compound treatment 132400.0 47200.0 0.78 58080.0 -33500.0 -0.53 0.1732 0.1835 3081458 TimTec1_000083 Brc1ccccc1NCn2nc(oc2=S)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D18 compound treatment 65120.0 -20100.0 -0.33 38600.0 -53000.0 -0.84 -0.8316 -0.9168 3209728 TimTec1_000084 Fc1ccccc1OC(=O)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D19 compound treatment 121880.0 36700.0 0.61 91400.0 -171.0 0.0 0.426 0.7039 1270584 TimTec1_000085 Cc1ccc(cc1)S(=O)(=O)N2c3ccccc3C(C)(CC2(C)C)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D20 compound treatment 128800.0 43600.0 0.72 79280.0 -12300.0 -0.2 0.3701 0.4965 3081461 TimTec1_000086 FC(F)(F)c1cccc(c1)c2ccc(/C=N\C3CCS(=O)(=O)C3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D21 compound treatment 7640.0 -77600.0 -1.28 5160.0 -86400.0 -1.38 -1.8794 -0.9993 1450123 TimTec1_000087 CCOC(=O)c1c(C)n(c2cccc(C)c2)c3ccc(O)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D22 compound treatment 18400.0 -66800.0 -1.1 18920.0 -72700.0 -1.16 -1.5988 -0.9997 3209729 TimTec1_000088 Cc1cccc(c1)C2Sc3ccccc3N=C4C2C(=O)c5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D23 mock treatment 116160.0 30900.0 0.51 83360.0 -8210.0 -0.13 0.2686 0.5094 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 D24 mock treatment 74640.0 -10600.0 -0.17 80760.0 -10800.0 -0.17 -0.2454 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E01 compound treatment 21120.0 -64100.0 -1.06 9360.0 -82200.0 -1.31 -1.6748 -0.9944 3209730 TimTec1_000089 CSc1ccccc1NC(=O)c2cc3NC4C(CCc5ccccc45)C(n3n2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E02 compound treatment 6200.0 -79000.0 -1.3 5120.0 -86500.0 -1.38 -1.8967 -0.9996 3081503 TimTec1_000090 Nc1c(C#N)c(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E03 compound treatment 101240.0 16000.0 0.26 103160.0 11600.0 0.18 0.3176 0.9846 3081507 TimTec1_000091 Cc1c(Br)c(nn1CC(=O)N2CCOCC2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E04 compound treatment 9080.0 -76100.0 -1.26 7080.0 -84500.0 -1.35 -1.841 -0.9994 1912602 TimTec1_000092 Brc1cccc(c1)C2C3CCCCC3=C(C#N)C(=O)C2(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E05 compound treatment 126680.0 41500.0 0.68 114600.0 23000.0 0.37 0.7434 0.9574 3209731 TimTec1_000093 C[N+](C)(C)CC1CCCC1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E06 compound treatment 123520.0 38300.0 0.63 126160.0 34600.0 0.55 0.8368 0.9977 3081510 TimTec1_000094 [N-]=[N+]=NCc1noc(n1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E07 compound treatment 41960.0 -43300.0 -0.71 40560.0 -51000.0 -0.81 -1.0799 -0.9979 1182023 TimTec1_000095 CCCN(C#N)c1nc(NC(C)C)nc(NC(C)C)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E08 compound treatment 131400.0 46200.0 0.76 69600.0 -22000.0 -0.35 0.2914 0.3474 3081512 TimTec1_000096 O=C(NCC[n+]1ccc2ccccc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E09 compound treatment 128360.0 43100.0 0.71 83840.0 -7730.0 -0.12 0.4164 0.5762 1029436 TimTec1_000097 OC(=O)CCC(=O)Oc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E10 compound treatment 127320.0 42100.0 0.69 107880.0 16300.0 0.26 0.6752 0.91 3209732 TimTec1_000098 Nc1ccc(OCC(O)C[n+]2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E11 compound treatment 127200.0 42000.0 0.69 96440.0 4870.0 0.08 0.5448 0.7814 3081515 TimTec1_000099 O=C(Nc1cccc(NC(=O)/C=C/c2ccco2)n1)/C=C/c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E12 compound treatment 123240.0 38000.0 0.63 127920.0 36300.0 0.58 0.8534 0.9992 1009007 TimTec1_000100 CCCC(=O)NCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E13 compound treatment 131560.0 46300.0 0.76 127440.0 35900.0 0.57 0.9451 0.9897 1705451 TimTec1_000101 CC1C2COCC2CC(C1O)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E14 compound treatment 125280.0 40100.0 0.66 120280.0 28700.0 0.46 0.7911 0.9838 1074947 TimTec1_000102 Cc1ccc[n+](Cc2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E15 compound treatment 123440.0 38200.0 0.63 79440.0 -12100.0 -0.19 0.3094 0.4689 1394494 TimTec1_000103 Nc1ccc(c2nc3cc(Cl)ccc3o2)c(O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E16 compound treatment 126760.0 41500.0 0.69 90600.0 -971.0 -0.02 0.4739 0.691 3209733 TimTec1_000104 CN(C)/C=C(\C=[N+](C)C)/c1cc([nH]n1)\C(=C/N(C)C)\C=[N+](C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E17 compound treatment 33160.0 -52100.0 -0.86 20280.0 -71300.0 -1.14 -1.4112 -0.9905 3081522 TimTec1_000105 Oc1ccc(Cl)cc1/N=C/c2ccc(o2)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E18 compound treatment 10240.0 -75000.0 -1.24 5400.0 -86200.0 -1.37 -1.8464 -0.9987 1633318 TimTec1_000106 Oc1ccc2occ(C(=O)c3ccc(Oc4ccccc4)cc3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E19 compound treatment 119800.0 34600.0 0.57 93240.0 1670.0 0.03 0.4224 0.7393 1221609 TimTec1_000107 CCOC(=O)C1(COC(=O)C1)c2csc(N)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E20 compound treatment 64680.0 -20500.0 -0.34 43960.0 -47600.0 -0.76 -0.7764 -0.9341 1365512 TimTec1_000108 CSc1c(CC(=O)NCCc2ccccc2)n(C)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E21 compound treatment 112200.0 27000.0 0.45 81840.0 -9730.0 -0.16 0.2052 0.4352 3081562 TimTec1_000109 Cc1c(/C=N/c2cccc3nsnc23)c(O)n4c5ccccc5nc4c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E22 compound treatment 9640.0 -75600.0 -1.25 7080.0 -84500.0 -1.35 -1.8345 -0.9993 1408177 TimTec1_000110 O=C(CCN1CCCCC1)c2cc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E23 mock treatment 90280.0 5060.0 0.08 106520.0 14900.0 0.24 0.2275 0.9012 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 E24 mock treatment 83720.0 -1500.0 -0.02 73000.0 -18600.0 -0.3 -0.2268 -0.7637 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F01 compound treatment 118800.0 33600.0 0.55 87960.0 -3610.0 -0.06 0.3512 0.6303 1212077 TimTec1_000111 CCOC(=O)c1cc2ccccc2nc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F02 compound treatment 124760.0 39500.0 0.65 101520.0 9950.0 0.16 0.5736 0.8541 3209734 TimTec1_000112 C=CCNC(=O)CC1CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F03 compound treatment 108560.0 23300.0 0.39 88280.0 -3290.0 -0.05 0.2353 0.6052 3209735 TimTec1_000113 COc1ccc(O)c(c1)c2c[nH]c(=S)nc2c3cc(OC)ccc3OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F04 compound treatment 109880.0 24700.0 0.41 88520.0 -3050.0 -0.05 0.2534 0.6182 1743325 TimTec1_000114 COc1ccc2nc3-c4cccc5cccc(-c3nc2c1)c45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F05 compound treatment 119280.0 34100.0 0.56 106480.0 14900.0 0.24 0.5656 0.9266 2104259 TimTec1_000115 Brc1cccc(c1)c2n[nH]c(=O)[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F06 compound treatment 160120.0 74900.0 1.24 131720.0 40100.0 0.64 1.3267 0.953 1644388 TimTec1_000116 O=S(=O)(CCc1ccncc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F07 compound treatment 80880.0 -4340.0 -0.07 66040.0 -25500.0 -0.41 -0.3384 -0.8191 1066566 TimTec1_000117 Cc1ccc(cc1)S(=O)(=O)N2CCC(=O)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F08 compound treatment 117560.0 32300.0 0.53 106240.0 14700.0 0.23 0.5428 0.9314 1595822 TimTec1_000118 Nc1ccc(cc1)C(=O)NCC2CCCN3CCCCC23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F09 compound treatment 113120.0 27900.0 0.46 97520.0 5950.0 0.09 0.3927 0.8352 3209736 TimTec1_000119 CN(C)Cc1c(C#N)c2ccccc2n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F10 compound treatment 118600.0 33400.0 0.55 104040.0 12500.0 0.2 0.5301 0.9051 3081571 TimTec1_000120 Cc1c(O)n(nc1/C=N/n2cnnc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F11 compound treatment 79640.0 -5580.0 -0.09 62560.0 -29000.0 -0.46 -0.3921 -0.8317 3209737 TimTec1_000121 Oc1ccc(cc1)n2cccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F12 compound treatment 29240.0 -56000.0 -0.92 29440.0 -62100.0 -0.99 -1.3537 -0.9994 1378112 TimTec1_000122 CC(C)(C)C(=O)c1sc2nc3CCCc3c(c4cccs4)c2c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F13 compound treatment 123240.0 38000.0 0.63 117880.0 26300.0 0.42 0.7403 0.9808 1389415 TimTec1_000123 Clc1cccc(OCCN2CCOCC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F14 compound treatment 47080.0 -38100.0 -0.63 37760.0 -53800.0 -0.86 -1.0517 -0.9884 3209738 TimTec1_000124 COc1ccc(C/N=C/C2C(=O)N(N=C2C(F)(F)F)c3nc4ccccc4s3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F15 compound treatment 85480.0 258.0 0.0 69560.0 -22000.0 -0.35 -0.2451 -0.6985 1562364 TimTec1_000125 CN1CCN(CCOc2ccccc2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F16 compound treatment 91560.0 6340.0 0.1 78920.0 -12700.0 -0.2 -0.0686 -0.302 1380422 TimTec1_000126 Brc1ccccc1OCc2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F17 compound treatment 100520.0 15300.0 0.25 92800.0 1230.0 0.02 0.1924 0.7597 1337811 TimTec1_000127 COc1ccc(NC(=O)c2ccc3nc(C)c(C)nc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F18 compound treatment 99840.0 14600.0 0.24 53480.0 -38100.0 -0.61 -0.2587 -0.3959 3209739 TimTec1_000128 O=C(/C=C/C(=O)c1ccccc1)N2c3ccccc3Sc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F19 compound treatment 8000.0 -77200.0 -1.27 6400.0 -85200.0 -1.36 -1.8613 -0.9995 1683844 TimTec1_000129 CC1(C)CC(C)(c2ccccc2)c3cc(SC#N)ccc3N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F20 compound treatment 58760.0 -26500.0 -0.44 58520.0 -33100.0 -0.53 -0.6814 -0.9957 1442200 TimTec1_000130 CC1CCN(CC(O)COc2c(F)cc(Br)cc2F)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F21 compound treatment 123240.0 38000.0 0.63 104440.0 12900.0 0.21 0.5888 0.8918 1404864 TimTec1_000131 OCCN(CCO)Cc1c(O)ccc2occ(C(=O)c3cccs3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F22 compound treatment 112200.0 27000.0 0.45 87600.0 -3970.0 -0.06 0.2701 0.6006 1413355 TimTec1_000132 CSC1=NC2(CCCCC2)NC3=C1CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F23 mock treatment 81800.0 -3420.0 -0.06 92000.0 429.0 0.01 -0.0351 -0.6171 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 F24 mock treatment 101560.0 16300.0 0.27 71600.0 -20000.0 -0.32 -0.0344 -0.0824 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G01 compound treatment 67240.0 -18000.0 -0.3 69520.0 -22100.0 -0.35 -0.4584 -0.9965 1746897 TimTec1_000133 CC1Cc2ccccc2N1C(=O)c3cccc(n3)C(=O)N4C(C)Cc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G02 compound treatment 7440.0 -77800.0 -1.28 7360.0 -84200.0 -1.34 -1.857 -0.9998 1210571 TimTec1_000134 CCOC(=O)C1(C#N)C(C=C(C(=C1N)C#N)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G03 compound treatment 54120.0 -31100.0 -0.51 48440.0 -43100.0 -0.69 -0.8491 -0.9897 1738871 TimTec1_000135 O=C(C1CC1(c2ccccc2)c3ccccc3)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G04 compound treatment 30560.0 -54700.0 -0.9 32800.0 -58800.0 -0.94 -1.3004 -0.9998 1495985 TimTec1_000136 CC(C)Cc1cc(c(C#N)c(N)n1)c2cccc(Br)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G05 compound treatment 85720.0 498.0 0.01 72520.0 -19100.0 -0.3 -0.2089 -0.6877 1728047 TimTec1_000137 CC(C)(C)c1cc(CCC(=O)NCCN)cc(c1O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G06 compound treatment 128320.0 43100.0 0.71 110280.0 18700.0 0.3 0.7139 0.9255 1006115 TimTec1_000138 CCN(CC)C1CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G07 compound treatment 9640.0 -75600.0 -1.25 9160.0 -82400.0 -1.31 -1.811 -0.9997 1442213 TimTec1_000139 CN(C)c1nc(Cl)nc(n1)N(CN2C(=O)c3ccccc3C2=O)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G08 compound treatment 134360.0 49100.0 0.81 113440.0 21900.0 0.35 0.82 0.9288 1391498 TimTec1_000140 Cc1nc2n(C)c(=O)n(C)c(=O)c2cc1C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G09 compound treatment 93560.0 8340.0 0.14 88320.0 -3250.0 -0.05 0.0607 0.4126 1225682 TimTec1_000141 CC(C)Nc1nc(NC(C)C)nc(n1)N(C)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G10 compound treatment 18880.0 -66300.0 -1.1 17520.0 -74100.0 -1.18 -1.6089 -0.9993 1485808 TimTec1_000142 Cc1cccc(C[N+](C)(C)CCC(=O)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G11 compound treatment 131760.0 46500.0 0.77 128320.0 36700.0 0.59 0.9574 0.991 1186157 TimTec1_000143 CC12CCCCC2=NC(N1O)c3ccccc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G12 compound treatment 117880.0 32700.0 0.54 109600.0 18000.0 0.29 0.5844 0.9566 1025931 TimTec1_000144 Cc1ccc(cc1)S(=O)(=O)NCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G13 compound treatment 71280.0 -13900.0 -0.23 95560.0 3990.0 0.06 -0.1178 -0.4933 1323961 TimTec1_000145 S=C(CC(=S)N1CCOCC1)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G14 compound treatment 119360.0 34100.0 0.56 117000.0 25400.0 0.41 0.6851 0.9869 3209861 TimTec1_000146 CC(=O)NC1CCCCc2sccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G15 compound treatment 104800.0 19600.0 0.32 100440.0 8870.0 0.14 0.3285 0.9312 1288570 TimTec1_000147 CCCC(CCC)c1nc2ccncc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G16 compound treatment 103280.0 18100.0 0.3 98600.0 7030.0 0.11 0.29 0.9107 3209862 TimTec1_000148 OC1=C(C2C3C(CCCC3=O)Oc4ccccc24)C(=O)CCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G17 compound treatment 104640.0 19400.0 0.32 100280.0 8710.0 0.14 0.3248 0.9299 3081632 TimTec1_000149 OC(=O)CCC/N=C(\c1ccc(Cl)cc1)/c2cc(F)ccc2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G18 compound treatment 52520.0 -32700.0 -0.54 43800.0 -47800.0 -0.76 -0.9201 -0.9858 1713094 TimTec1_000150 CN(C)Cc1c(O)ccc2occ(C(=O)c3cccc(Br)c3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G19 compound treatment 114160.0 28900.0 0.48 115520.0 23900.0 0.38 0.6077 0.9938 3081667 TimTec1_000151 CCCC1CC(C)(OC1=O)C(=O)C[n+]2cccc(c2)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G20 compound treatment 98760.0 13500.0 0.22 101360.0 9790.0 0.16 0.2683 0.9846 1405391 TimTec1_000152 COc1ccc(OC)c(c1)C(=O)c2coc3ccc(O)cc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G21 compound treatment 105720.0 20500.0 0.34 104400.0 12800.0 0.2 0.3838 0.9709 3081670 TimTec1_000153 CC(C)C1(CN2CC/3CN(C1)CC2)\C3=N/N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G22 compound treatment 90800.0 5580.0 0.09 81960.0 -9610.0 -0.15 -0.0432 -0.2418 1185154 TimTec1_000154 CCOC(=O)Cn1c(C)c(Sc2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G23 mock treatment 80560.0 -4660.0 -0.08 90800.0 -771.0 -0.01 -0.0631 -0.8098 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 G24 mock treatment 82680.0 -2540.0 -0.04 91160.0 -411.0 -0.01 -0.0343 -0.8077 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H01 compound treatment 85840.0 618.0 0.01 93080.0 1510.0 0.02 0.0242 0.927 1114526 TimTec1_000155 NC(=O)c1ccccc1C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H02 compound treatment 78280.0 -6940.0 -0.11 91480.0 -91.3 0.0 -0.0821 -0.716 3209863 TimTec1_000156 CC(C)c1ccc(cc1)C(C)(C)CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H03 compound treatment 73760.0 -11500.0 -0.19 86680.0 -4890.0 -0.08 -0.1889 -0.9232 1440514 TimTec1_000157 COc1ccccc1OCCN2CCN(CC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H04 compound treatment 89000.0 3780.0 0.06 90920.0 -651.0 -0.01 0.0368 0.5814 3081674 TimTec1_000158 Cc1c(/C=C/c2ccc(Cl)cc2Cl)c(=O)n(c3ccccc3)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H05 compound treatment 110120.0 24900.0 0.41 126000.0 34400.0 0.55 0.6786 0.9899 3209864 TimTec1_000159 COc1ccc(Br)c2OCCOc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H06 compound treatment 86680.0 1460.0 0.02 103440.0 11900.0 0.19 0.1508 0.7907 3209865 TimTec1_000160 COc1ccc(NC(=O)CC(=O)CSc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H07 compound treatment 41640.0 -43600.0 -0.72 47800.0 -43800.0 -0.7 -1.002 -0.9999 1282382 TimTec1_000161 CN1CCN(Cc2c(C#N)c3ccccc3n2C)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H08 compound treatment 95440.0 10200.0 0.17 124600.0 33000.0 0.53 0.4915 0.8891 1156260 TimTec1_000162 O=C(CSc1nc2ccccc2o1)Nc3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H09 compound treatment 96680.0 11500.0 0.19 102960.0 11400.0 0.18 0.2621 0.9998 1296268 TimTec1_000163 Cn1c(CN2CCOCC2)c(C#N)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H10 compound treatment 92600.0 7380.0 0.12 96920.0 5350.0 0.09 0.1464 0.9848 1566355 TimTec1_000164 C1CCC(CC1)Nc2c(nnn2C3CCCCC3)c4ccn[nH]4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H11 compound treatment 119720.0 34500.0 0.57 121160.0 29600.0 0.47 0.7361 0.9956 3081679 TimTec1_000165 CNC(=O)CCc1cc2ccccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H12 compound treatment 128120.0 42900.0 0.71 109840.0 18300.0 0.29 0.7066 0.9229 1429944 TimTec1_000166 NC(=S)c1cnc2ccccn2c1=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H13 compound treatment 106840.0 21600.0 0.36 116960.0 25400.0 0.4 0.5385 0.998 1210033 TimTec1_000167 O=C(CCN1CCN(CC1)c2ccccc2)Nc3nccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H14 compound treatment 95640.0 10400.0 0.17 103360.0 11800.0 0.19 0.2545 0.999 3209866 TimTec1_000168 FC(F)(F)c1[nH]n(c2nc3ccccc3s2)c(=O)c1/C=N/CCN4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H15 compound treatment 45400.0 -39800.0 -0.66 41120.0 -50500.0 -0.8 -1.0334 -0.995 3081684 TimTec1_000169 COc1ccc(/C=N/c2oc(C)c(C)c2C#N)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H16 compound treatment 51240.0 -34000.0 -0.56 59920.0 -31700.0 -0.5 -0.7534 -0.9986 3209867 TimTec1_000170 C[n+]1c(COc2ccccc2O)sc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H17 compound treatment 25760.0 -59500.0 -0.98 31000.0 -60600.0 -0.97 -1.3767 -1.0 1912978 TimTec1_000171 CC(=O)N1c2ccccc2C(C)(CC1(C)C)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H18 compound treatment 116120.0 30900.0 0.51 107840.0 16300.0 0.26 0.544 0.9508 3081687 TimTec1_000172 Cn1ccnc1C(=O)Oc2ccccc2F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H19 compound treatment 38000.0 -47200.0 -0.78 39680.0 -51900.0 -0.83 -1.136 -0.9996 1280653 TimTec1_000173 CC1=CC(C)(C)N(c2ccccc12)S(=O)(=O)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H20 compound treatment 89360.0 4140.0 0.07 102000.0 10400.0 0.17 0.1658 0.9228 3209868 TimTec1_000174 O=c1[nH]c2ccc(/N=C/c3ccc4OCOc4c3)cc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H21 compound treatment 108720.0 23500.0 0.39 109680.0 18100.0 0.29 0.4784 0.9894 3081729 TimTec1_000175 Nc1no[n+]([O-])c1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H22 compound treatment 74400.0 -10800.0 -0.18 82000.0 -9570.0 -0.15 -0.2342 -0.9969 3081731 TimTec1_000176 CCOc1ccc2S/C(=C/NC(C)CC)/C(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H23 mock treatment 106040.0 20800.0 0.34 103920.0 12300.0 0.2 0.3822 0.965 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 H24 mock treatment 55000.0 -30200.0 -0.5 72800.0 -18800.0 -0.3 -0.5643 -0.9701 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I01 compound treatment 50640.0 -34600.0 -0.57 85800.0 -5770.0 -0.09 -0.4687 -0.8106 1160113 TimTec1_000177 Cc1ccccc1OCC(=O)Nc2ccc3nn(nc3c2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I02 compound treatment 47320.0 -37900.0 -0.63 64680.0 -26900.0 -0.43 -0.7455 -0.983 1912584 TimTec1_000178 Nc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I03 compound treatment 69600.0 -15600.0 -0.26 99840.0 8270.0 0.13 -0.0892 -0.3079 3081734 TimTec1_000179 COC(=O)CCC(=O)Nc1nccs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I04 compound treatment 44200.0 -41000.0 -0.68 80120.0 -11500.0 -0.18 -0.6079 -0.8668 1175548 TimTec1_000180 CC(=O)Nc1nc(cc(c1C#N)c2ccccc2)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I05 compound treatment 107040.0 21800.0 0.36 118400.0 26800.0 0.43 0.557 0.9964 1060191 TimTec1_000181 S=C1N(CN2CCCCC2)CCN1CN3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I06 compound treatment 94360.0 9140.0 0.15 114280.0 22700.0 0.36 0.3626 0.9247 3209869 TimTec1_000182 CC[N+](C)(CC)Cc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I07 compound treatment 94400.0 9180.0 0.15 102080.0 10500.0 0.17 0.2256 0.9987 3209870 TimTec1_000183 Cc1cc(NN)nc(SCC(=O)NN)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I08 compound treatment 102640.0 17400.0 0.29 108480.0 16900.0 0.27 0.3939 0.9995 1289525 TimTec1_000184 C[N+]1(CC(O)C[N+]2(C)CCCCC2)CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I09 compound treatment 37840.0 -47400.0 -0.78 37320.0 -54300.0 -0.86 -1.1645 -0.9987 1505713 TimTec1_000185 C1=C(N=C2C=Cc3nonc3C12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I10 compound treatment 100600.0 15400.0 0.25 107360.0 15800.0 0.25 0.3574 1.0 1080215 TimTec1_000186 OP(=O)(Nc1ccccc1)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I11 compound treatment 104840.0 19600.0 0.32 125200.0 33600.0 0.54 0.608 0.9709 3209871 TimTec1_000187 Cc1c(Br)c(nn1CC(=O)N)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I12 compound treatment 127360.0 42100.0 0.7 130680.0 39100.0 0.62 0.9326 0.9985 1668354 TimTec1_000188 O=C(N1CCCCC1)c2ccccc2C(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I13 compound treatment 115040.0 29800.0 0.49 143240.0 51700.0 0.82 0.9304 0.9697 1230919 TimTec1_000189 CN(C)CCNc1nc(no1)c2noc(NCCN(C)C)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I14 compound treatment 110880.0 25700.0 0.42 118280.0 26700.0 0.43 0.6005 1.0 1641088 TimTec1_000190 C[N+]1(CC(O)CN2CCCC2=O)CCCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I15 compound treatment 94520.0 9300.0 0.15 107800.0 16200.0 0.26 0.2914 0.9689 1479834 TimTec1_000191 CC1(C)CC(CC(C)(C)N1)NC(=O)N2c3ccccc3CCc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I16 compound treatment 90120.0 4900.0 0.08 100640.0 9070.0 0.14 0.1594 0.9623 3209872 TimTec1_000192 CCOC(=O)C1(C#N)C(C#N)(C(=O)OCC)C1(C#N)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I17 compound treatment 24720.0 -60500.0 -1.0 29640.0 -61900.0 -0.99 -1.4042 -1.0 1350657 TimTec1_000193 COc1ccc2NC(C)(C)c3ssc(=S)c3-c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I18 compound treatment 17480.0 -67700.0 -1.12 24640.0 -66900.0 -1.07 -1.545 -0.9997 1439817 TimTec1_000194 CC(=O)Oc1ccc2occ(C(=O)c3cc4ccccc4o3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I19 compound treatment 69080.0 -16100.0 -0.27 91360.0 -211.0 0.0 -0.1908 -0.716 1619809 TimTec1_000195 Nc1nc(cc(c1C#N)c2ccccc2Cl)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I20 compound treatment 6720.0 -78500.0 -1.3 8480.0 -83100.0 -1.32 -1.8528 -0.9999 1402303 TimTec1_000196 CN(C)CCC(=O)c1coc2ccc(OC(=O)C)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I21 compound treatment 68680.0 -16500.0 -0.27 77360.0 -14200.0 -0.23 -0.3533 -0.9957 3209873 TimTec1_000197 C/C(=N\n1nnnc1Nc2ccccc2)/c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I22 compound treatment 114080.0 28900.0 0.48 122760.0 31200.0 0.5 0.6883 0.9998 1447918 TimTec1_000198 COC(=O)CCC(=O)c1cc2cc(Br)ccc2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I23 mock treatment 95840.0 10600.0 0.18 114960.0 23400.0 0.37 0.3875 0.9408 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 I24 mock treatment 64440.0 -20800.0 -0.34 65640.0 -25900.0 -0.41 -0.5348 -0.9957 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J01 compound treatment 79040.0 -6180.0 -0.1 114080.0 22500.0 0.36 0.1815 0.4866 1078582 TimTec1_000199 NC(=O)c1ccc2ccccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J02 compound treatment 57080.0 -28100.0 -0.46 94480.0 2910.0 0.05 -0.2957 -0.6334 1032512 TimTec1_000200 O=C1N(CNc2ccccc2)C(=O)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J03 compound treatment 53440.0 -31800.0 -0.52 82760.0 -8810.0 -0.14 -0.4703 -0.8659 1725358 TimTec1_000201 Cc1ccc(cc1)S(=O)(=O)CCN2CCN(CC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J04 compound treatment 85000.0 -223.0 0.0 79840.0 -11700.0 -0.19 -0.1348 -0.7209 1122981 TimTec1_000202 O=C1NC(=O)c2cc(ccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J05 compound treatment 79280.0 -5940.0 -0.1 113640.0 22100.0 0.35 0.1794 0.4912 1020688 TimTec1_000203 Cc1ccc(NC(=O)CC(=O)Nc2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J06 compound treatment 43240.0 -42000.0 -0.69 60120.0 -31500.0 -0.5 -0.8445 -0.9874 1386865 TimTec1_000204 COC(=O)c1ccc(NC(=O)COc2cccc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J07 compound treatment 83440.0 -1780.0 -0.03 118760.0 27200.0 0.43 0.2856 0.6576 1498066 TimTec1_000205 CC(=O)Nc1c(oc2ccccc12)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J08 compound treatment 97120.0 11900.0 0.2 132680.0 41100.0 0.66 0.6022 0.8804 1326858 TimTec1_000206 CN1CCc2c(C1)c(nc3[nH]nc(N)c23)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J09 compound treatment 43000.0 -42200.0 -0.7 58080.0 -33500.0 -0.53 -0.8703 -0.9913 1734489 TimTec1_000207 Cn1c(CSCc2ccccc2)c(C#N)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J10 compound treatment 99640.0 14400.0 0.24 126200.0 34600.0 0.55 0.5586 0.9293 3209874 TimTec1_000208 O/N=C\1/C2CN3CC1(Cc4ccccc4)CN(C2)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J11 compound treatment 105640.0 20400.0 0.34 123720.0 32100.0 0.51 0.6006 0.9793 3081797 TimTec1_000209 S(c1ccccn1)c2ncnc3c4ccccc4oc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J12 compound treatment 122880.0 37700.0 0.62 124520.0 32900.0 0.53 0.8109 0.9965 3209875 TimTec1_000210 CCOC(=O)[C@@]1(C#N)[C@H]([C@@H](N2C=C(C=C[C@H]21)C(=O)N)C(=O)N)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J13 compound treatment 97320.0 12100.0 0.2 137640.0 46100.0 0.73 0.6604 0.8679 3081799 TimTec1_000211 C(Sc1ncnc2c3ccccc3oc12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J14 compound treatment 63920.0 -21300.0 -0.35 82120.0 -9450.0 -0.15 -0.3552 -0.9284 3081800 TimTec1_000212 FC(F)(F)c1[nH]n(c2nc3ccccc3s2)c(=O)c1/C=N/Cc4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J15 compound treatment 122680.0 37500.0 0.62 145680.0 54100.0 0.86 1.047 0.9867 1498770 TimTec1_000213 COc1cc(OC)cc(c1)C(=O)N2CCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J16 compound treatment 84120.0 -1100.0 -0.02 143040.0 51500.0 0.82 0.5672 0.6912 1358111 TimTec1_000214 Oc1ccccc1OCC(=O)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J17 compound treatment 85800.0 578.0 0.01 121360.0 29800.0 0.47 0.3425 0.7212 1091978 TimTec1_000215 CCOC(=O)CN=C(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J18 compound treatment 14240.0 -71000.0 -1.17 16960.0 -74600.0 -1.19 -1.6694 -1.0 1917358 TimTec1_000216 CN1CCN(CC(O)COCCC2(CC3CC4CC(C3)C2)C4)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J19 compound treatment 56000.0 -29200.0 -0.48 107080.0 15500.0 0.25 -0.1663 -0.3068 1066363 TimTec1_000217 COc1ccc2NC(C)(C)C=C(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J20 compound treatment 96080.0 10900.0 0.18 120320.0 28700.0 0.46 0.4507 0.9161 1921867 TimTec1_000218 On1c(nc-2c1CCc3c2no[n+]3[O-])c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J21 compound treatment 75640.0 -9580.0 -0.16 131240.0 39700.0 0.63 0.3352 0.5143 3081805 TimTec1_000219 Nc1c(no[n+]1[O-])C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J22 compound treatment 74640.0 -10600.0 -0.17 113080.0 21500.0 0.34 0.1189 0.309 1879059 TimTec1_000220 CNC(=O)N(Cc1cccnc1)Cc2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J23 mock treatment 98960.0 13700.0 0.23 96480.0 4910.0 0.08 0.2157 0.8991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 J24 mock treatment 80880.0 -4340.0 -0.07 78960.0 -12600.0 -0.2 -0.1928 -0.9035 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K01 compound treatment 57720.0 -27500.0 -0.45 111840.0 20300.0 0.32 -0.0926 -0.1662 1259801 TimTec1_000221 CS(=O)(=O)c1ccc2nc(NC(=O)C3CCCO3)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K02 compound treatment 11400.0 -73800.0 -1.22 19120.0 -72500.0 -1.15 -1.6782 -0.9996 1151146 TimTec1_000222 Nc1c(C#N)c(c2ccccc2)c3CCCCc3c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K03 compound treatment 36400.0 -48800.0 -0.81 57120.0 -34500.0 -0.55 -0.9581 -0.9825 1392387 TimTec1_000223 Brc1ccc(o1)C(=O)Nc2ccc3OCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K04 compound treatment 67200.0 -18000.0 -0.3 133920.0 42300.0 0.67 0.2669 0.3619 1275980 TimTec1_000224 Clc1ccc(OCC(=O)NCC=C)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K05 compound treatment 11640.0 -73600.0 -1.21 29560.0 -62000.0 -0.99 -1.5578 -0.9948 1285366 TimTec1_000225 Cc1cccc(CN2CCN(Cc3cccc(C)c3O)CC2)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K06 compound treatment 98440.0 13200.0 0.22 126920.0 35300.0 0.56 0.5527 0.9147 3081809 TimTec1_000226 Cc1cc(C)nc(SCC(=O)NN)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K07 compound treatment 84920.0 -303.0 0.0 114840.0 23300.0 0.37 0.2587 0.6975 1584109 TimTec1_000227 NNC(=O)C1CC2CC1CC2C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K08 compound treatment 80040.0 -5180.0 -0.09 126840.0 35300.0 0.56 0.337 0.5927 1914424 TimTec1_000228 C(=N/C(\N=C\c1ccccc1)c2ccccc2)\c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K09 compound treatment 98720.0 13500.0 0.22 126680.0 35100.0 0.56 0.5532 0.9185 3081861 TimTec1_000229 COC(=O)c1ccc(NC(=S)NC(=O)N2CCOCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K10 compound treatment 100720.0 15500.0 0.26 123840.0 32300.0 0.51 0.5446 0.948 3209999 TimTec1_000230 CC(=O)OC1COC(NC(=S)Oc2ccccc2)C(OC(=O)C)C1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K11 compound treatment 116120.0 30900.0 0.51 122040.0 30500.0 0.49 0.704 0.9997 3081863 TimTec1_000231 CCOC(=O)Cn1nc(cc1C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K12 compound treatment 71880.0 -13300.0 -0.22 95320.0 3750.0 0.06 -0.1135 -0.4973 3210000 TimTec1_000232 COc1ccc(/C=C/C(=O)OC2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K13 compound treatment 7440.0 -77800.0 -1.28 9840.0 -81700.0 -1.3 -1.829 -1.0 3081865 TimTec1_000233 c1ccc(cc1)c2cnc3nonc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K14 compound treatment 63640.0 -21600.0 -0.36 80160.0 -11400.0 -0.18 -0.3805 -0.9513 1474168 TimTec1_000234 COc1ccc(CCN(C)C(=S)NN)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K15 compound treatment 67800.0 -17400.0 -0.29 112560.0 21000.0 0.33 0.0332 0.0752 1445690 TimTec1_000235 OC(=O)c1cc2cccc(c2cc1O)S(=O)(=O)N3CCCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K16 compound treatment 28000.0 -57200.0 -0.94 46920.0 -44700.0 -0.71 -1.1712 -0.9903 1033126 TimTec1_000236 Cc1ccc(cc1)S(=O)(=O)Nc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K17 compound treatment 28640.0 -56600.0 -0.93 62000.0 -29600.0 -0.47 -0.9937 -0.9498 1183681 TimTec1_000237 COc1cc(NC(=O)Cc2ccc(F)cc2)cc(c1)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K18 compound treatment 62960.0 -22300.0 -0.37 105520.0 13900.0 0.22 -0.1027 -0.239 1604299 TimTec1_000238 COc1cc2c(NC(=O)C)c(CN(C)C)oc2c(Cl)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K19 compound treatment 47840.0 -37400.0 -0.62 95400.0 3830.0 0.06 -0.3932 -0.6341 3210001 TimTec1_000239 NS(=O)(=O)c1ccc(NC=C2C(=O)c3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K20 compound treatment 4720.0 -80500.0 -1.33 7120.0 -84500.0 -1.35 -1.8914 -1.0 3081870 TimTec1_000240 CCOC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K21 compound treatment 61280.0 -23900.0 -0.4 91920.0 349.0 0.01 -0.2755 -0.6971 3210002 TimTec1_000241 S=c1n(CN(Cc2ccccc2)Cc3ccccc3)nnn1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K22 compound treatment 5280.0 -79900.0 -1.32 7720.0 -83900.0 -1.34 -1.8781 -1.0 1023688 TimTec1_000242 CN(C)CCC(=O)c1ccco1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K23 mock treatment 84680.0 -543.0 -0.01 89080.0 -2490.0 -0.04 -0.0344 -0.8453 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 K24 mock treatment 54760.0 -30500.0 -0.5 116680.0 25100.0 0.4 -0.0726 -0.1129 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L01 compound treatment 57920.0 -27300.0 -0.45 99040.0 7470.0 0.12 -0.2345 -0.5031 1264988 TimTec1_000243 COc1cc(N)c(Cl)cc1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L02 compound treatment 72640.0 -12600.0 -0.21 100560.0 8990.0 0.14 -0.0456 -0.1806 1706058 TimTec1_000244 CC(=O)N(CN1C(=O)c2ccccc2C1=O)c3ccccc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L03 compound treatment 70240.0 -15000.0 -0.25 115520.0 23900.0 0.38 0.095 0.2089 1357677 TimTec1_000245 CNC(=O)c1cnc2cc(Cl)ccc2c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L04 compound treatment 63280.0 -21900.0 -0.36 115600.0 24000.0 0.38 0.0147 0.0279 1569209 TimTec1_000246 O=S(=O)(NC1c2ccccc2Oc3ccccc13)c4ccc5ccccc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L05 compound treatment 70400.0 -14800.0 -0.24 111920.0 20300.0 0.32 0.0563 0.1386 1015215 TimTec1_000247 COc1ccc(NC(=O)CC(=O)Nc2ccc(OC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L06 compound treatment 86480.0 1260.0 0.02 126640.0 35100.0 0.56 0.4099 0.7329 1490465 TimTec1_000248 COc1ccc(SCC(=O)Nc2ccccn2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L07 compound treatment 68640.0 -16600.0 -0.27 143720.0 52100.0 0.83 0.3942 0.4504 1204062 TimTec1_000249 CSc1c(CC(=O)NN)n(C)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L08 compound treatment 73680.0 -11500.0 -0.19 149120.0 57500.0 0.92 0.5139 0.5485 1235682 TimTec1_000250 CCc1nc2[nH]nc(N)c2c3CC(C)(C)OCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L09 compound treatment 58440.0 -26800.0 -0.44 80360.0 -11200.0 -0.18 -0.439 -0.9206 3081877 TimTec1_000251 O=C(/C=C/N1CCOCC1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L10 compound treatment 80080.0 -5140.0 -0.08 119760.0 28200.0 0.45 0.2577 0.5635 3210003 TimTec1_000252 C[n+]1ccc(/C=C/c2cccs2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L11 compound treatment 49000.0 -36200.0 -0.6 80960.0 -10600.0 -0.17 -0.5424 -0.8729 1338690 TimTec1_000253 CN(C)Cc1c(O)ccc2occ(C(=O)c3ccc(C)cc3)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L12 compound treatment 63400.0 -21800.0 -0.36 87960.0 -3610.0 -0.06 -0.2954 -0.8098 1654307 TimTec1_000254 CC1(C)Cc2c(C#N)c3nc(cnn3c2CO1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L13 compound treatment 6720.0 -78500.0 -1.3 10120.0 -81500.0 -1.3 -1.8343 -1.0 1245793 TimTec1_000255 CCc1oc2ccccc2c1C(=O)c3ccc(OC(=O)C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L14 compound treatment 95200.0 9980.0 0.16 129320.0 37700.0 0.6 0.5419 0.8687 3081942 TimTec1_000256 CN(C)S(=O)(=O)c1ccc(N/C=C\2/C(=C(C#N)C(=O)N(C)C2=O)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L15 compound treatment 5560.0 -79700.0 -1.32 9560.0 -82000.0 -1.31 -1.8541 -1.0 1570064 TimTec1_000257 Cc1ccc2nc(Nc3ccccc3)cc(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L16 compound treatment 52120.0 -33100.0 -0.55 106960.0 15400.0 0.25 -0.213 -0.3555 1509985 TimTec1_000258 C=CCC1CCCCC1NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L17 compound treatment 20880.0 -64300.0 -1.06 33720.0 -57900.0 -0.92 -1.403 -0.9975 1455868 TimTec1_000259 COc1cccc(NC(=O)c2ccc(OC(=S)N3CCC(C)CC3)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L18 compound treatment 37040.0 -48200.0 -0.8 69280.0 -22300.0 -0.36 -0.8136 -0.934 3210004 TimTec1_000260 Fc1ccc(/N=C/c2ccc(OC(=O)c3ccco3)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L19 compound treatment 40600.0 -44600.0 -0.74 49520.0 -42100.0 -0.67 -0.9948 -0.9989 1369950 TimTec1_000261 CCOc1ccc2N(C)C(C)(C)c3ssc(=S)c3-c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L20 compound treatment 14560.0 -70700.0 -1.17 18560.0 -73000.0 -1.16 -1.6477 -1.0 3210005 TimTec1_000262 NC(=O)[C@H]1[C@H](c2ccc(F)cc2)C(C#N)(C#N)[C@H]3N1C=Cc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L21 compound treatment 45840.0 -39400.0 -0.65 56560.0 -35000.0 -0.56 -0.8543 -0.9971 1298997 TimTec1_000263 CCOC(=O)c1c(CNc2cccc(c2)C(=O)N)n(C)c3cc(Br)c(OC(=O)C)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L22 compound treatment 63200.0 -22000.0 -0.36 93600.0 2030.0 0.03 -0.2342 -0.6417 1677367 TimTec1_000264 O=C(Nc1c(cnn1c2ccccc2)C(=O)N3CCCCC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L23 mock treatment 68920.0 -16300.0 -0.27 96560.0 4990.0 0.08 -0.1341 -0.4778 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 L24 mock treatment 53120.0 -32100.0 -0.53 102840.0 11300.0 0.18 -0.2477 -0.4427 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M01 compound treatment 42200.0 -43000.0 -0.71 92880.0 1310.0 0.02 -0.4874 -0.686 1321921 TimTec1_000265 OC1(N(C(=O)Nc2ccccc21)c3ccccc3)C(=O)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M02 compound treatment 23640.0 -61600.0 -1.02 30760.0 -60800.0 -0.97 -1.4042 -0.9997 3081949 TimTec1_000266 CCC1(C)C/C(=C\C)/C(=C(N)C1(C#N)C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M03 compound treatment 52040.0 -33200.0 -0.55 100880.0 9310.0 0.15 -0.2824 -0.4976 1666559 TimTec1_000267 COc1cc(NS(=O)(=O)c2ccc(NC(=S)NC(=O)c3ccco3)cc2)ncn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M04 compound treatment 49400.0 -35800.0 -0.59 96120.0 4550.0 0.07 -0.3669 -0.6158 1006470 TimTec1_000268 C[N+](C)(Cc1ccccc1)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M05 compound treatment 44480.0 -40700.0 -0.67 90520.0 -1050.0 -0.02 -0.4874 -0.7245 3210006 TimTec1_000269 O=S(N1CCOCC1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M06 compound treatment 78120.0 -7100.0 -0.12 121800.0 30200.0 0.48 0.2578 0.5199 3081952 TimTec1_000270 S=C(Nc1ccccc1)N=S(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M07 compound treatment 61840.0 -23400.0 -0.39 129760.0 38200.0 0.61 0.1575 0.2185 1489996 TimTec1_000271 COC1OC2COC(OC2CC1O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M08 compound treatment 62400.0 -22800.0 -0.38 148520.0 56900.0 0.91 0.3754 0.382 3210007 TimTec1_000272 O=C(c1ccccc1)c2cc[n+](Cc3ccccn3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M09 compound treatment 84200.0 -1020.0 -0.02 126080.0 34500.0 0.55 0.377 0.6851 3210008 TimTec1_000273 Cc1ccc(/C=C/C(=O)NC(=S)N2CCN(CC2)c3ccc(F)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M10 compound treatment 86120.0 898.0 0.01 124120.0 32500.0 0.52 0.3773 0.727 1433383 TimTec1_000274 CCCOC(=S)NC1OCC(O)C(O)C1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M11 compound treatment 22720.0 -62500.0 -1.03 37280.0 -54300.0 -0.87 -1.3414 -0.9962 1720341 TimTec1_000275 O=C(Nc1ccc(cc1)c2ccccc2)C3CC3c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M12 compound treatment 87280.0 2060.0 0.03 105840.0 14300.0 0.23 0.1848 0.8038 3081955 TimTec1_000276 COc1ccc(/C=C/C(=O)NC(C)(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M13 compound treatment 109040.0 23800.0 0.39 126440.0 34900.0 0.56 0.671 0.9856 1475730 TimTec1_000277 CCOC(=O)c1nonc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M14 compound treatment 6080.0 -79100.0 -1.31 10400.0 -81200.0 -1.29 -1.8386 -1.0 3082017 TimTec1_000278 Clc1ccc(cc1)C2=NN=C(SC2)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M15 compound treatment 35040.0 -50200.0 -0.83 83520.0 -8050.0 -0.13 -0.6765 -0.807 1344248 TimTec1_000279 CCN(CC)CCC(O)(C1CCCCC1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M16 compound treatment 55200.0 -30000.0 -0.5 131960.0 40400.0 0.64 0.1048 0.1289 1532600 TimTec1_000280 Cc1nc2ccccc2cc1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M17 compound treatment 57040.0 -28200.0 -0.47 103600.0 12000.0 0.19 -0.1934 -0.3843 3210120 TimTec1_000281 COc1ccc(cc1)c2cc(n3nc(cc3n2)C(=O)NCCN4CCOCC4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M18 compound treatment 40840.0 -44400.0 -0.73 74240.0 -17300.0 -0.28 -0.7134 -0.9111 1325986 TimTec1_000282 Cc1ccc(o1)C(=O)c2coc3ccc(O)cc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M19 compound treatment 58160.0 -27100.0 -0.45 95000.0 3430.0 0.05 -0.2772 -0.616 3210121 TimTec1_000283 OCC(CO)(CO)NC=C1C(=O)c2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M20 compound treatment 48040.0 -37200.0 -0.61 76280.0 -15300.0 -0.24 -0.6063 -0.9181 1295715 TimTec1_000284 OC(=O)CCCc1cc2cc(Br)ccc2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M21 compound treatment 14440.0 -70800.0 -1.17 16880.0 -74700.0 -1.19 -1.668 -1.0 3210122 TimTec1_000285 Brc1ccc(/N=C(\c2ccccc2)/c3ccncc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M22 compound treatment 42400.0 -42800.0 -0.71 48080.0 -43500.0 -0.69 -0.99 -1.0 1536799 TimTec1_000286 Clc1cccc(NC(=O)NCCN2CCCCC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M23 mock treatment 103800.0 18600.0 0.31 107600.0 16000.0 0.26 0.3975 0.9959 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 M24 mock treatment 67640.0 -17600.0 -0.29 89160.0 -2410.0 -0.04 -0.2324 -0.7938 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N01 compound treatment 42800.0 -42400.0 -0.7 88880.0 -2690.0 -0.04 -0.5255 -0.749 1530149 TimTec1_000287 CCCCN1CCC(CC1)(Nc2ccccc2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N02 compound treatment 61080.0 -24100.0 -0.4 127480.0 35900.0 0.57 0.1229 0.1762 1146434 TimTec1_000288 O=C(COC(=O)c1ccc(cc1)N2C(=O)c3ccccc3C2=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N03 compound treatment 28400.0 -56800.0 -0.94 47000.0 -44600.0 -0.71 -1.1656 -0.9906 1353615 TimTec1_000289 CCOC(=O)c1c(CN(CC)CC)oc2ccc(OC)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N04 compound treatment 48200.0 -37000.0 -0.61 90280.0 -1290.0 -0.02 -0.4467 -0.7305 1022729 TimTec1_000290 O=C1N(C2c3ccccc3Oc4ccccc24)C(=O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N05 compound treatment 63560.0 -21700.0 -0.36 120320.0 28700.0 0.46 0.0712 0.1224 3082023 TimTec1_000291 O=C1N(/N=C/c2ccccc2)C(=O)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N06 compound treatment 60240.0 -25000.0 -0.41 134120.0 42500.0 0.68 0.1879 0.2368 3210123 TimTec1_000292 O=C(CSc1ccccn1)Nc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N07 compound treatment 47600.0 -37600.0 -0.62 126320.0 34700.0 0.55 -0.0475 -0.0571 3082025 TimTec1_000293 Cc1cc(n[nH]1)c2cc(C)[nH]n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N08 compound treatment 51400.0 -33800.0 -0.56 142120.0 50500.0 0.81 0.1749 0.1784 1617345 TimTec1_000294 CN1CCc2c(C1)c(NCCO)nc3[nH]nc(N)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N09 compound treatment 24400.0 -60800.0 -1.0 41480.0 -50100.0 -0.8 -1.2745 -0.9936 1226159 TimTec1_000295 C(Cc1ccncc1)Nc2ccc(OCc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N10 compound treatment 51240.0 -34000.0 -0.56 75360.0 -16200.0 -0.26 -0.5794 -0.9381 3210124 TimTec1_000296 COc1ccc2c(C)nc(N/C(=N/C(=O)C)/N)nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N11 compound treatment 61720.0 -23500.0 -0.39 126840.0 35300.0 0.56 0.1232 0.1803 1294429 TimTec1_000297 CC(=O)Nc1c(oc2ccc(Br)cc12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N12 compound treatment 90720.0 5500.0 0.09 119480.0 27900.0 0.44 0.3787 0.8342 3210125 TimTec1_000298 CC1(C)Cc2c(C#N)c(=S)[nH]c(N3CCOCC3)c2CS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N13 compound treatment 55800.0 -29400.0 -0.49 91880.0 309.0 0.0 -0.34 -0.6999 1155921 TimTec1_000299 N#CC(CCN1CCN(CC1)c2ccccc2)(c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N14 compound treatment 84080.0 -1140.0 -0.02 135200.0 43600.0 0.7 0.4784 0.6877 1441186 TimTec1_000300 C1CCC(CC1)c2nnc(o2)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N15 compound treatment 62360.0 -22900.0 -0.38 128280.0 36700.0 0.59 0.1469 0.2109 3210126 TimTec1_000301 CCC(C)C1=NN(C(=O)c2ccccc2)C(O)(C1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N16 compound treatment 20400.0 -64800.0 -1.07 61480.0 -30100.0 -0.48 -1.0958 -0.9345 3082032 TimTec1_000302 Cc1ccc(cc1)c2ccc(OC(=O)c3ccccc3F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N17 compound treatment 10720.0 -74500.0 -1.23 40560.0 -51000.0 -0.81 -1.4445 -0.9798 1424431 TimTec1_000303 CC1=CC(C)(C)N(Cc2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N18 compound treatment 36080.0 -49100.0 -0.81 87240.0 -4330.0 -0.07 -0.6224 -0.7645 3081117 TimTec1_000304 Fc1ccc(/N=C/c2ccc(OC(=O)c3cccs3)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N19 compound treatment 38720.0 -46500.0 -0.77 108800.0 17200.0 0.27 -0.3486 -0.4276 3210127 TimTec1_000305 CC(C)C(=O)N1c2ccc(C)cc2-c3c(ssc3=S)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N20 compound treatment 45200.0 -40000.0 -0.66 90440.0 -1130.0 -0.02 -0.4799 -0.7261 3081119 TimTec1_000306 CCOc1cc(/C=C/2\SCOC2=O)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N21 compound treatment 58080.0 -27100.0 -0.45 109760.0 18200.0 0.29 -0.1118 -0.2095 1693566 TimTec1_000307 CCOC(=O)c1c(C)n(C)c2ccc(O)c(c12)S(=O)(=O)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N22 compound treatment 41760.0 -43500.0 -0.72 50960.0 -40600.0 -0.65 -0.965 -0.9987 1465551 TimTec1_000308 Fc1ccc(CC(=O)NC2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N23 mock treatment 64400.0 -20800.0 -0.34 93080.0 1510.0 0.02 -0.226 -0.656 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 N24 mock treatment 80400.0 -4820.0 -0.08 94000.0 2430.0 0.04 -0.0289 -0.3267 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O01 compound treatment 52840.0 -32400.0 -0.53 75640.0 -15900.0 -0.25 -0.5575 -0.9421 1586093 TimTec1_000309 OC1(N(C(=O)Nc2ccccc21)c3ccccc3)C(=O)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O02 compound treatment 41840.0 -43400.0 -0.72 49760.0 -41800.0 -0.67 -0.9776 -0.9994 1502323 TimTec1_000310 Nc1nc2CCCc2c(c1C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O03 compound treatment 46440.0 -38800.0 -0.64 106960.0 15400.0 0.25 -0.2792 -0.4073 3210128 TimTec1_000311 NC(=N)NS(=O)(=O)c1ccc(NC(=S)NC(=O)/C=C/c2ccc(F)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O04 compound treatment 54680.0 -30500.0 -0.5 84080.0 -7490.0 -0.12 -0.4409 -0.851 1176923 TimTec1_000312 C[N+](C)(CCC#N)Cc1cccc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O05 compound treatment 29320.0 -55900.0 -0.92 111840.0 20300.0 0.32 -0.4241 -0.4338 3081123 TimTec1_000313 S=C(SN1CCOCC1)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O06 compound treatment 61960.0 -23300.0 -0.38 129960.0 38400.0 0.61 0.1611 0.223 1002693 TimTec1_000314 COC1OC2COC(OC2C(O)C1O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O07 compound treatment 41520.0 -43700.0 -0.72 134160.0 42600.0 0.68 -0.0301 -0.0304 1507393 TimTec1_000315 CCCOC(=S)NC1OCC(OC(=O)C)C(OC(=O)C)C1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O08 compound treatment 51960.0 -33300.0 -0.55 146400.0 54800.0 0.87 0.2297 0.2225 3081125 TimTec1_000316 C(c1ccccc1)c2ccc[n+](Cc3ccccn3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O09 compound treatment 46960.0 -38300.0 -0.63 122000.0 30400.0 0.48 -0.1037 -0.1302 3210129 TimTec1_000317 Cc1cc(C)n(n1)C(=O)COc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O10 compound treatment 30480.0 -54700.0 -0.9 79600.0 -12000.0 -0.19 -0.7739 -0.8379 1676440 TimTec1_000318 CC12CCC3C(CC=C4CC(CCC34C)OC5CCCCO5)C2CCC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O11 compound treatment 61680.0 -23500.0 -0.39 116040.0 24500.0 0.39 0.001 0.0018 1921096 TimTec1_000319 O=C1NC(=O)C2(COC(OC2)c3ccccc3)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O12 compound treatment 67040.0 -18200.0 -0.3 97040.0 5470.0 0.09 -0.1506 -0.4819 3081128 TimTec1_000320 COc1ccc(/C=C/C(=O)NCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O13 compound treatment 94280.0 9060.0 0.15 124400.0 32800.0 0.52 0.4757 0.8742 3081129 TimTec1_000321 COc1nonc1NC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O14 compound treatment 34680.0 -50500.0 -0.83 72840.0 -18700.0 -0.3 -0.8011 -0.904 1215803 TimTec1_000322 CN(C)CCSc1nc2ccccc2c(=O)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O15 compound treatment 66440.0 -18800.0 -0.31 124160.0 32600.0 0.52 0.148 0.2447 1134169 TimTec1_000323 COc1ccc(c2nc3nnc(C)n3[nH]2)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O16 compound treatment 25040.0 -60200.0 -0.99 61520.0 -30100.0 -0.48 -1.0412 -0.944 1165035 TimTec1_000324 CCOC(=O)c1c(CN2CCCCC2)n(c3ccccc3)c4ccc(OC(=O)C)cc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O17 compound treatment 42040.0 -43200.0 -0.71 127360.0 35800.0 0.57 -0.1007 -0.1103 3210130 TimTec1_000325 CC(=O)Nc1ccc(/N=C/c2ccc(cc2)N3CCOCC3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O18 compound treatment 47280.0 -37900.0 -0.63 128240.0 36700.0 0.58 -0.0296 -0.0346 1656585 TimTec1_000326 OC(=O)C(Cc1ccsc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O19 compound treatment 59760.0 -25500.0 -0.42 129440.0 37900.0 0.6 0.1296 0.1762 3081133 TimTec1_000327 CC1(C)CC(=O)C(=CNC(CO)(CO)CO)C(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O20 compound treatment 36320.0 -48900.0 -0.81 59600.0 -32000.0 -0.51 -0.9311 -0.9754 3210131 TimTec1_000328 CCOC(=O)c1c(CNC(C)C)oc2ccc(OC)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O21 compound treatment 4960.0 -80300.0 -1.32 7000.0 -84600.0 -1.35 -1.89 -1.0 3210132 TimTec1_000329 Cc1ccc(C)c(c1)[C@H]2[C@@H](N3C(C=Cc4ccccc34)C2(C#N)C#N)C(=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O22 compound treatment 27040.0 -58200.0 -0.96 55920.0 -35700.0 -0.57 -1.0809 -0.9686 1145302 TimTec1_000330 CCOC(=O)c1c(C)n(C2CCCCC2)c3ccc(O)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O23 mock treatment 83880.0 -1340.0 -0.02 118520.0 26900.0 0.43 0.288 0.6697 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 O24 mock treatment 74120.0 -11100.0 -0.18 98120.0 6550.0 0.1 -0.0558 -0.2645 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P01 compound treatment 60680.0 -24500.0 -0.41 52080.0 -39500.0 -0.63 -0.7315 -0.9773 1004729 TimTec1_000331 COC(=O)c1ccccc1C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P02 compound treatment 41760.0 -43500.0 -0.72 49080.0 -42500.0 -0.68 -0.9862 -0.9996 3210133 TimTec1_000332 O=C(Oc1cc(OC(=O)c2ccco2)cc(OC(=O)c3ccco3)c1)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P03 compound treatment 26600.0 -58600.0 -0.97 40320.0 -51300.0 -0.82 -1.2619 -0.9964 3081813 TimTec1_000333 CCOC(=O)Cc1c(SC)c2ccccc2n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P04 compound treatment 37880.0 -47300.0 -0.78 52920.0 -38700.0 -0.62 -0.9882 -0.9931 3081814 TimTec1_000334 CCN(CC)CCOc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P05 compound treatment 61000.0 -24200.0 -0.4 106760.0 15200.0 0.24 -0.1116 -0.2387 3210134 TimTec1_000335 O=C(Cc1ccccc1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P06 compound treatment 53800.0 -31400.0 -0.52 124680.0 33100.0 0.53 0.0064 0.0086 1158366 TimTec1_000336 O=C(Nc1ccccc1)C(=S)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P07 compound treatment 18440.0 -66800.0 -1.1 53080.0 -38500.0 -0.61 -1.2133 -0.9617 1365315 TimTec1_000337 CCOC(=O)c1c(COC(=O)C)n(C)c2cc(Br)c(OC)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P08 compound treatment 39000.0 -46200.0 -0.76 110920.0 19300.0 0.31 -0.3215 -0.3906 1268733 TimTec1_000338 Nc1c(N2CCN(CC2)c3ccccc3)c4ccccc4oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P09 compound treatment 35160.0 -50100.0 -0.83 92840.0 1270.0 0.02 -0.57 -0.6896 1047274 TimTec1_000339 CC(=O)Nc1ccc(OCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P10 compound treatment 30080.0 -55100.0 -0.91 61120.0 -30500.0 -0.49 -0.9868 -0.9566 1459196 TimTec1_000340 CCSc1nnc-2c(OC3(Nc4ccccc42)C(=O)Nc5ccc(Br)cc53)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P11 compound treatment 29640.0 -55600.0 -0.92 96040.0 4470.0 0.07 -0.5984 -0.6503 1347458 TimTec1_000341 CCOC(=O)c1oc2ccccc2c1NC(=O)CCN3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P12 compound treatment 36040.0 -49200.0 -0.81 65760.0 -25800.0 -0.41 -0.865 -0.9504 1693186 TimTec1_000342 Cc1nn2c(=O)c3CCCc3[nH]c2c1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P13 compound treatment 24240.0 -61000.0 -1.01 78000.0 -13600.0 -0.22 -0.8648 -0.8399 1228757 TimTec1_000343 CC1(C)CC(=O)c2c(c([nH]c2C1)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P14 compound treatment 60000.0 -25200.0 -0.42 119480.0 27900.0 0.44 0.0201 0.033 3081883 TimTec1_000344 NCCCc1nc2cc3sc(CCCN)nc3cc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P15 compound treatment 48000.0 -37200.0 -0.61 118720.0 27100.0 0.43 -0.1285 -0.171 1650512 TimTec1_000345 CC1=NN(C(=O)Cc2ccccc2)C(O)(C1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P16 compound treatment 28400.0 -56800.0 -0.94 99240.0 7670.0 0.12 -0.5768 -0.6098 3081885 TimTec1_000346 N#Cc1ccc(C#N)c(c1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P17 compound treatment 31520.0 -53700.0 -0.89 110240.0 18700.0 0.3 -0.4164 -0.4453 3081886 TimTec1_000347 Cc1ccc(cc1)C2=C/C(=C/3\OC(=O)c4ccccc34)/C(=O)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P18 compound treatment 28840.0 -56400.0 -0.93 74880.0 -16700.0 -0.27 -0.8462 -0.8742 3210253 TimTec1_000348 COC(=O)NC(Nc1ccccc1C(F)(F)F)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P19 compound treatment 45600.0 -39600.0 -0.65 86080.0 -5490.0 -0.09 -0.5244 -0.7946 1111738 TimTec1_000349 Cc1nc(NC(=N)N)nc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P20 compound treatment 64560.0 -20700.0 -0.34 98480.0 6910.0 0.11 -0.1633 -0.4557 1449841 TimTec1_000350 OC(=O)CCN1C(=O)C2C(C3c4ccccc4C2c5ccccc35)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P21 compound treatment 56480.0 -28700.0 -0.47 83480.0 -8090.0 -0.13 -0.4267 -0.8678 1530469 TimTec1_000351 O=C(CSc1nc2ccccc2s1)NC3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P22 compound treatment 42360.0 -42900.0 -0.71 32200.0 -59400.0 -0.95 -1.1694 -0.9897 1494539 TimTec1_000352 CCCN(CCC)C(=O)c1cnn(c1NC(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P23 mock treatment 63560.0 -21700.0 -0.36 80400.0 -11200.0 -0.18 -0.3788 -0.9482 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2063 P24 mock treatment 90240.0 5020.0 0.08 55360.0 -36200.0 -0.58 -0.3495 -0.5995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A01 compound treatment 60720.0 -26800.0 -0.44 115600.0 8830.0 0.14 -0.2138 -0.4598 3081276 TimTec1_000705 CN(C)C(=O)c1cc(Cl)ccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A02 compound treatment 68640.0 -18900.0 -0.31 72640.0 -34100.0 -0.54 -0.6055 -0.9653 1727664 TimTec1_000706 Cc1cccc(NC(=O)c2cnn(c2NC(=O)c3ccco3)c4ccccc4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A03 compound treatment 146760.0 59200.0 0.98 119880.0 13100.0 0.21 0.8388 0.8394 1225534 TimTec1_000707 O=C(CC(c1ccccc1)c2ccccc2)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A04 compound treatment 49920.0 -37600.0 -0.62 44560.0 -62200.0 -0.99 -1.1405 -0.9747 3211034 TimTec1_000708 COC(=O)CSc1nc(ccc1C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A05 compound treatment 217440.0 130000.0 2.14 140880.0 34100.0 0.54 1.9004 0.8592 1669652 TimTec1_000709 O=C(CSc1nc2ccccc2o1)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A06 compound treatment 202840.0 115000.0 1.9 89760.0 -17000.0 -0.27 1.1539 0.6003 1013954 TimTec1_000710 COC(=O)c1cccc(c1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A07 compound treatment 225960.0 138000.0 2.28 66200.0 -40600.0 -0.65 1.1582 0.4878 1089954 TimTec1_000711 OC(=O)c1ccc(Oc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A08 compound treatment 160400.0 72800.0 1.2 59960.0 -46800.0 -0.75 0.3227 0.228 1005718 TimTec1_000712 OC(=O)CCC(=O)OCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A09 compound treatment 9520.0 -78000.0 -1.29 4720.0 -102000.0 -1.63 -2.061 -0.9933 1474924 TimTec1_000713 CN(C)Cc1ccc(cc1)C(=O)Oc2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A10 compound treatment 25680.0 -61900.0 -1.02 4040.0 -103000.0 -1.64 -1.8801 -0.9742 3211035 TimTec1_000714 Oc1cccc(/N=C/c2cc(Br)ccc2O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A11 compound treatment 188120.0 101000.0 1.66 57720.0 -49000.0 -0.78 0.621 0.3384 3081282 TimTec1_000715 Cc1ccc(O)c(c1)C2=Nc3ccccc3N=C(C2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A12 compound treatment 141320.0 53800.0 0.89 68160.0 -38600.0 -0.62 0.1924 0.1782 1433969 TimTec1_000716 Cc1cccc(c1)C(=O)NN(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A13 compound treatment 203000.0 115000.0 1.91 100040.0 -6730.0 -0.11 1.2716 0.6663 1483255 TimTec1_000717 CC(=O)Nc1cccc2ncccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A14 compound treatment 128000.0 40400.0 0.67 66680.0 -40100.0 -0.64 0.0202 0.0219 1158197 TimTec1_000718 COc1ccc(cc1)C(=O)Nc2ccc(C)c(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A15 compound treatment 171640.0 84100.0 1.39 99120.0 -7650.0 -0.12 0.8952 0.6425 3211036 TimTec1_000719 C/C(=N\n1cnnc1)/CC(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A16 compound treatment 116800.0 29200.0 0.48 53920.0 -52800.0 -0.84 -0.2543 -0.262 1075886 TimTec1_000720 FC(F)(F)c1cccc(NS(=O)(=O)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A17 compound treatment 174440.0 86900.0 1.43 80080.0 -26700.0 -0.43 0.7133 0.4769 1922764 TimTec1_000721 OC(=O)c1cc(/N=C/c2ccccc2O)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A18 compound treatment 108040.0 20500.0 0.34 38320.0 -68400.0 -1.09 -0.5324 -0.4661 1340286 TimTec1_000722 COc1ccc(cc1)S(=O)(=O)Nc2cc(C)cc(C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A19 compound treatment 7760.0 -79800.0 -1.32 4360.0 -102000.0 -1.63 -2.0856 -0.9943 1715796 TimTec1_000723 CCOC(=O)c1c(CSc2nc(C)ccc2C#N)oc3ccc(OC(=O)C)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A20 compound treatment 128840.0 41300.0 0.68 97840.0 -8930.0 -0.14 0.3812 0.5477 3211037 TimTec1_000724 COC(=O)C1=C(N)C(=c2s/c(=C/c3ccccc3)/c(=O)n2C1c4ccccc4)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A21 compound treatment 7160.0 -80400.0 -1.33 4880.0 -102000.0 -1.62 -2.0868 -0.995 3081301 TimTec1_000725 NC1=C(C#N)[C@@H]([C@H](S1)C(=O)c2ccccc2)c3ccc(Br)c(F)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A22 compound treatment 113200.0 25600.0 0.42 94280.0 -12500.0 -0.2 0.1585 0.339 1561863 TimTec1_000726 O=C(Nc1nc(nc2CCCC(=O)c12)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A23 mock treatment 101680.0 14100.0 0.23 113920.0 7150.0 0.11 0.2454 0.9459 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 A24 mock treatment 63800.0 -23800.0 -0.39 97600.0 -9170.0 -0.15 -0.3807 -0.9094 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B01 compound treatment 73600.0 -14000.0 -0.23 90680.0 -16100.0 -0.26 -0.3443 -0.9986 3081303 TimTec1_000727 Cc1cccc[n+]1C2[C@H](C(=C(S)N[C@]2(C)O)C#N)c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B02 compound treatment 133960.0 46400.0 0.77 141680.0 34900.0 0.56 0.9351 0.9877 3211038 TimTec1_000728 CC1C(CC(C(=O)O)C1(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B03 compound treatment 181160.0 93600.0 1.55 117400.0 10600.0 0.17 1.2124 0.78 3211039 TimTec1_000729 CC1=COC=C(/C=N/Cc2ccccc2)N1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B04 compound treatment 12440.0 -75100.0 -1.24 7600.0 -99200.0 -1.58 -1.9945 -0.9928 3081306 TimTec1_000730 O=C(CSC#N)c1cccs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B05 compound treatment 94200.0 6640.0 0.11 98640.0 -8130.0 -0.13 -0.0141 -0.0832 1225786 TimTec1_000731 COc1cccc2c1N(C3CC(C)CCC3C2(C)C)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B06 compound treatment 130920.0 43400.0 0.72 81800.0 -25000.0 -0.4 0.2247 0.2744 1605606 TimTec1_000732 c1ccc(nc1)c2ccc3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B07 compound treatment 173480.0 85900.0 1.42 86760.0 -20000.0 -0.32 0.7774 0.5348 1478193 TimTec1_000733 CCC(=O)Nc1ncc2C(=O)CC(C)(C)Cc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B08 compound treatment 226160.0 139000.0 2.29 80440.0 -26300.0 -0.42 1.3211 0.5679 3081309 TimTec1_000734 COc1ccc(cc1)/C(=N/O)/C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B09 compound treatment 201160.0 114000.0 1.88 113840.0 7070.0 0.11 1.4057 0.7483 3211040 TimTec1_000735 CCOC(=O)Cc1n[nH]c(CC(=O)OCC)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B10 compound treatment 17880.0 -69700.0 -1.15 10680.0 -96100.0 -1.53 -1.8963 -0.99 3081311 TimTec1_000736 Nc1ccc2nn(nc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B11 compound treatment 215280.0 128000.0 2.11 85480.0 -21300.0 -0.34 1.2509 0.5858 1090166 TimTec1_000737 CN(C)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B12 compound treatment 214760.0 127000.0 2.1 150760.0 44000.0 0.7 1.9805 0.8947 3081313 TimTec1_000738 CCOc1ccc(cc1)C(=O)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B13 compound treatment 197400.0 110000.0 1.81 135480.0 28700.0 0.46 1.6057 0.8587 3211041 TimTec1_000739 COc1cccc(/C=N/n2cnnc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B14 compound treatment 212040.0 124000.0 2.05 146480.0 39700.0 0.63 1.9005 0.8839 3211042 TimTec1_000740 C[N+]1(C/C=C\2/COCO2)CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B15 compound treatment 211760.0 124000.0 2.05 106280.0 -486.0 -0.01 1.4442 0.7044 1498488 TimTec1_000741 COc1ccc(CC(=O)NC2CCCCC2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B16 compound treatment 168040.0 80500.0 1.33 68920.0 -37800.0 -0.6 0.5128 0.3515 3211043 TimTec1_000742 OC(=O)c1cc(/C=N/n2cnnc2)c3OCOCc3c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B17 compound treatment 82000.0 -5560.0 -0.09 60160.0 -46600.0 -0.74 -0.5902 -0.7885 3211044 TimTec1_000743 Cc1nc(cs1)C2C(Oc3c(O)c(O)ccc3C2=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B18 compound treatment 9360.0 -78200.0 -1.29 4920.0 -102000.0 -1.62 -2.0606 -0.9936 3081317 TimTec1_000744 OC(CN1CC2CC(C1)c3cccc(=O)n3C2)/C=N/n4cnnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B19 compound treatment 147400.0 59800.0 0.99 66920.0 -39800.0 -0.64 0.2494 0.2124 3081354 TimTec1_000745 C(/C=C\c1ccccc1)N2CCN(Cn3nnc4ccccc34)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B20 compound treatment 183400.0 95800.0 1.58 153280.0 46500.0 0.74 1.6429 0.9403 3081321 TimTec1_000746 CC(CN1CC2CC(C1)c3cccc(=O)n3C2)SC(=N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B21 compound treatment 130640.0 43100.0 0.71 91120.0 -15600.0 -0.25 0.3265 0.4333 1281576 TimTec1_000747 CN(C1CCCCC1)S(=O)(=O)c2ccc(NC(=O)C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B22 compound treatment 45960.0 -41600.0 -0.69 34440.0 -72300.0 -1.15 -1.3007 -0.9694 1293326 TimTec1_000748 CC1(C)CC(=O)C2=C(C1)Nc3ccc4ccccc4c3C2c5cccnc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B23 mock treatment 138200.0 50600.0 0.84 114360.0 7590.0 0.12 0.6766 0.8011 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 B24 mock treatment 128720.0 41200.0 0.68 108800.0 2030.0 0.03 0.5033 0.74 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C01 compound treatment 155480.0 67900.0 1.12 82520.0 -24200.0 -0.39 0.5195 0.4381 3081323 TimTec1_000749 CC1CCN(CC1)C(=O)c2cc(Cl)ccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C02 compound treatment 161280.0 73700.0 1.22 127320.0 20600.0 0.33 1.0921 0.8666 1165155 TimTec1_000750 CCN(CC)C(=O)c1cnn(c1NC(=O)c2ccco2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C03 compound treatment 13800.0 -73800.0 -1.22 8160.0 -98600.0 -1.57 -1.9723 -0.992 3081325 TimTec1_000751 CCN(CC)c1ccc(/C=N/O)c(O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C04 compound treatment 177960.0 90400.0 1.49 124320.0 17600.0 0.28 1.253 0.8253 1058529 TimTec1_000752 OC(=O)c1ccccc1N2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C05 compound treatment 111440.0 23900.0 0.39 94600.0 -12200.0 -0.19 0.1416 0.3223 1643767 TimTec1_000753 CSc1nc2ccccc2n1CC(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C06 compound treatment 170400.0 82800.0 1.37 130000.0 23200.0 0.37 1.2288 0.8674 1016928 TimTec1_000754 CC(C)CNC(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C07 compound treatment 146760.0 59200.0 0.98 49520.0 -57200.0 -0.91 0.0458 0.0343 3211045 TimTec1_000755 Cc1ccc(C)n1c2ccc(cc2)C(=O)OCC(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C08 compound treatment 163880.0 76300.0 1.26 72840.0 -33900.0 -0.54 0.5085 0.3709 1586419 TimTec1_000756 CC1CC2OC(C)(C)OC2C(OC(=O)c3ccccc3)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C09 compound treatment 182160.0 94600.0 1.56 93600.0 -13200.0 -0.21 0.9558 0.6066 1233022 TimTec1_000757 CC(C)CCOc1ccccc1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C10 compound treatment 58320.0 -29200.0 -0.48 41960.0 -64800.0 -1.03 -1.0717 -0.94 3081330 TimTec1_000758 Cc1ccc(/N=C/c2cc3ccccc3nc2Cl)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C11 compound treatment 57000.0 -30600.0 -0.5 25360.0 -81400.0 -1.3 -1.2742 -0.9153 3211046 TimTec1_000759 FC(F)(F)c1cc(no1)c2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C12 compound treatment 154200.0 66600.0 1.1 150560.0 43800.0 0.7 1.2714 0.9759 3081332 TimTec1_000760 Cc1cccc(c1)C(=O)N(CC#N)CC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C13 compound treatment 143200.0 55600.0 0.92 165800.0 59000.0 0.94 1.3147 0.9999 3211047 TimTec1_000761 O=C(NN1C(=O)c2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C14 compound treatment 194840.0 107000.0 1.77 141720.0 35000.0 0.56 1.6461 0.8867 1022870 TimTec1_000762 O=C(NCc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C15 compound treatment 72840.0 -14700.0 -0.24 55320.0 -51400.0 -0.82 -0.7517 -0.8789 3211048 TimTec1_000763 C(=N/c1cccnc1)\c2c[nH]c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C16 compound treatment 170080.0 82500.0 1.36 71840.0 -34900.0 -0.56 0.5695 0.3871 1045873 TimTec1_000764 O=S(=O)(NCCc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C17 compound treatment 176360.0 88800.0 1.47 80560.0 -26200.0 -0.42 0.7411 0.4863 3211049 TimTec1_000765 Cc1c(/N=C/c2cccc(C)c2)c(=O)n(c3ccccc3)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C18 compound treatment 99720.0 12200.0 0.2 69920.0 -36800.0 -0.59 -0.2734 -0.4405 1634239 TimTec1_000766 O=C(CCCC(=O)Nc1cccc2ccccc12)Nc3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C19 compound treatment 9080.0 -78500.0 -1.3 4760.0 -102000.0 -1.63 -2.0657 -0.9937 3081336 TimTec1_000767 O=C(CSc1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C20 compound treatment 124840.0 37300.0 0.62 104200.0 -2570.0 -0.04 0.4062 0.6587 1173423 TimTec1_000768 CCOC(=O)C1=C(C(=O)c2ccccc2)C3(C(=O)Nc4ccccc43)C(=C(N)O1)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C21 compound treatment 130040.0 42500.0 0.7 77240.0 -29500.0 -0.47 0.163 0.1931 1130405 TimTec1_000769 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C32CCN(Cc4ccccc4)CC3)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C22 compound treatment 91360.0 3800.0 0.06 78040.0 -28700.0 -0.46 -0.2794 -0.6047 3211050 TimTec1_000770 Cc1cc(c2c(n1)sc3c(=O)[nH]c(C)nc32)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C23 mock treatment 116160.0 28600.0 0.47 105840.0 -926.0 -0.01 0.3234 0.6847 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 C24 mock treatment 97760.0 10200.0 0.17 98440.0 -8330.0 -0.13 0.0252 0.1175 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D01 compound treatment 113160.0 25600.0 0.42 90600.0 -16200.0 -0.26 0.1166 0.2356 1332544 TimTec1_000771 CCCN1CCC2(CC1)C(C#N)C(=O)NC(=C2C#N)S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D02 compound treatment 93400.0 5840.0 0.1 86680.0 -20100.0 -0.32 -0.1582 -0.4733 1267101 TimTec1_000772 CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN4CCOCC4)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D03 compound treatment 58360.0 -29200.0 -0.48 59520.0 -47200.0 -0.75 -0.8733 -0.9768 3211051 TimTec1_000773 C(/N=C/C1=CSC=CN1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D04 compound treatment 105800.0 18200.0 0.3 102560.0 -4210.0 -0.07 0.1655 0.5365 1527522 TimTec1_000774 S=c1n(CN2CCCCC2)nc(c3ccccc3)n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D05 compound treatment 28360.0 -59200.0 -0.98 22480.0 -84300.0 -1.34 -1.641 -0.9878 1323715 TimTec1_000775 CC1C=C(C)C2C(C)C1COC2c3ccc(OC(=O)NC4CCCCC4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D06 compound treatment 11280.0 -76300.0 -1.26 7960.0 -98800.0 -1.57 -2.004 -0.9939 1445377 TimTec1_000776 CC12CCC(C(=O)CO)C2(C)CCC3(C)C4(C)CCC(=O)C=C4CCC13C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D07 compound treatment 90360.0 2800.0 0.05 50360.0 -56400.0 -0.9 -0.6031 -0.6699 3209076 TimTec1_000777 FC(F)(F)c1cc(nc2cc(nn12)C(=O)N(Cc3ccccc3)Cc4ccccc4)c5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D08 compound treatment 55200.0 -32400.0 -0.53 26000.0 -80800.0 -1.29 -1.288 -0.9241 1519326 TimTec1_000778 CCOC(=O)C1=C(CC2=C1CCCC2)NC(=S)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D09 compound treatment 14120.0 -73400.0 -1.21 43680.0 -63100.0 -1.01 -1.5682 -0.9957 1679838 TimTec1_000779 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D10 compound treatment 121080.0 33500.0 0.55 99080.0 -7690.0 -0.12 0.3046 0.5375 1574797 TimTec1_000780 CCCC(=O)Nc1ccc(N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D11 compound treatment 112800.0 25200.0 0.42 42840.0 -63900.0 -1.02 -0.4259 -0.3869 3209077 TimTec1_000781 CCOC(=O)c1c(NC(=O)OC)sc2CCCCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D12 compound treatment 10560.0 -77000.0 -1.27 8560.0 -98200.0 -1.57 -2.0056 -0.9947 1560316 TimTec1_000782 CCOC(=O)c1ccc(NC(=O)c2ccc(cc2)C(C)(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D13 compound treatment 10840.0 -76700.0 -1.27 8480.0 -98300.0 -1.57 -2.0032 -0.9944 3081341 TimTec1_000783 Nc1nc(nc(n1)C(F)(F)F)N(Cc2ccccc2)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D14 compound treatment 132000.0 44400.0 0.73 108440.0 1670.0 0.03 0.5376 0.7323 3209078 TimTec1_000784 Cc1ccoc1CC[N+](C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D15 compound treatment 113880.0 26300.0 0.43 78360.0 -28400.0 -0.45 -0.013 -0.0206 1672714 TimTec1_000785 COc1ccccc1CC(=O)N(CC=C)CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D16 compound treatment 139800.0 52200.0 0.86 104680.0 -2090.0 -0.03 0.5862 0.6793 3209079 TimTec1_000786 C1COc2cccc(/C=N\n3cnnc3)c2OC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D17 compound treatment 94840.0 7280.0 0.12 49000.0 -57800.0 -0.92 -0.5661 -0.6097 3209080 TimTec1_000787 CCC(O)c1ccc2c(=O)c(coc2c1)c3ccccc3F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D18 compound treatment 8760.0 -78800.0 -1.3 5320.0 -101000.0 -1.62 -2.0631 -0.9942 3209081 TimTec1_000788 Cc1c(/N=C/C(O)CN2CC3CC(C2)c4cccc(=O)n4C3)c(=O)n(c5ccccc5)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D19 compound treatment 23360.0 -64200.0 -1.06 8400.0 -98400.0 -1.57 -1.858 -0.9818 3081342 TimTec1_000789 CC(C)Cc1ccc(/C=C/C(=O)N2CCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D20 compound treatment 68400.0 -19200.0 -0.32 10720.0 -96000.0 -1.53 -1.3061 -0.8356 3081343 TimTec1_000790 CC(=O)N1CCCCC1c2cccnc2.[O-][N+](=O)O[Ag] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D21 compound treatment 118080.0 30500.0 0.5 95920.0 -10800.0 -0.17 0.234 0.4393 1588159 TimTec1_000791 CS(=O)(=O)Nc1ccc2CCc3cccc1c32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D22 compound treatment 126920.0 39400.0 0.65 100640.0 -6130.0 -0.1 0.3904 0.5942 1287290 TimTec1_000792 COC(=O)c1c(C)nc(C)c2c(=O)oc3ccccc3c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D23 mock treatment 98640.0 11100.0 0.18 116160.0 9390.0 0.15 0.2352 0.9951 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 D24 mock treatment 104440.0 16900.0 0.28 68000.0 -38800.0 -0.62 -0.2399 -0.354 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E01 compound treatment 16240.0 -71300.0 -1.18 14480.0 -92300.0 -1.47 -1.8726 -0.9939 1535367 TimTec1_000793 CCC(C)c1ccc(NC(=O)c2ccc(cc2)N(CC)CC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E02 compound treatment 101400.0 13800.0 0.23 68240.0 -38500.0 -0.61 -0.2727 -0.4162 1215550 TimTec1_000794 CC(C)(C)C(=O)Nc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E03 compound treatment 24720.0 -62800.0 -1.04 25320.0 -81400.0 -1.3 -1.6514 -0.9938 1689344 TimTec1_000795 Clc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)Cc3ccccc3)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E04 compound treatment 75320.0 -12200.0 -0.2 72720.0 -34000.0 -0.54 -0.5266 -0.9094 3209082 TimTec1_000796 O(c1ccccc1)c2ccc(/C=N/c3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E05 compound treatment 43840.0 -43700.0 -0.72 41320.0 -65400.0 -1.04 -1.2479 -0.9838 3081345 TimTec1_000797 NC(CSCc1oc(cc1C(=O)O)c2ccccc2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E06 compound treatment 75240.0 -12300.0 -0.2 72160.0 -34600.0 -0.55 -0.5339 -0.9081 1921518 TimTec1_000798 COc1ccc(NC(=O)/C=C/c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E07 compound treatment 129480.0 41900.0 0.69 108520.0 1750.0 0.03 0.509 0.7351 1601233 TimTec1_000799 OC(=O)C1C(C2CCC1C2)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E08 compound treatment 134960.0 47400.0 0.78 119640.0 12900.0 0.21 0.6983 0.8634 3081347 TimTec1_000800 CCOC1(C)OC2CCC(CC)OC2O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E09 compound treatment 58160.0 -29400.0 -0.49 44920.0 -61800.0 -0.99 -1.0402 -0.9467 3082473 TimTec1_000801 CCc1ccc(cc1)C(=O)CSc2nnc(c3cccc(OC)c3)n2CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E10 compound treatment 95840.0 8280.0 0.14 72920.0 -33800.0 -0.54 -0.2848 -0.5118 3082474 TimTec1_000802 COc1cc(/N=C/c2cc3cccc(C)c3nc2Cl)c(OC)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E11 compound treatment 25760.0 -61800.0 -1.02 23160.0 -83600.0 -1.33 -1.6636 -0.9913 3209083 TimTec1_000803 CCCC[n+]1cc(nc(n1)N2CCCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E12 compound treatment 134400.0 46800.0 0.77 125000.0 18200.0 0.29 0.7522 0.9107 3209084 TimTec1_000804 O=C(Cc1ccccc1)NC2CCCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E13 compound treatment 76920.0 -10600.0 -0.18 81600.0 -25200.0 -0.4 -0.4079 -0.9314 1914322 TimTec1_000805 Clc1ccc(/N=C/c2c[nH]c3ccccc23)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E14 compound treatment 125040.0 37500.0 0.62 123880.0 17100.0 0.27 0.6303 0.9323 1916639 TimTec1_000806 O=C(c1ccccc1)n2cnc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E15 compound treatment 88120.0 558.0 0.01 75400.0 -31400.0 -0.5 -0.347 -0.694 1607222 TimTec1_000807 COc1ccc(cc1)C2(Cc3nc4ccccc4[nH]3)C(=O)c5ccccc5C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E16 compound treatment 86480.0 -1080.0 -0.02 58840.0 -47900.0 -0.76 -0.5528 -0.7235 1418431 TimTec1_000808 O=S(=O)(NC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E17 compound treatment 58600.0 -29000.0 -0.48 52000.0 -54800.0 -0.87 -0.9553 -0.9599 3082475 TimTec1_000809 Fc1ccc(/C=N/c2ccc(I)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E18 compound treatment 115080.0 27500.0 0.45 76240.0 -30500.0 -0.49 -0.0228 -0.0343 1450437 TimTec1_000810 COC(=O)c1cc(NS(=O)(=O)c2ccccc2)cc(c1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E19 compound treatment 64760.0 -22800.0 -0.38 54080.0 -52700.0 -0.84 -0.8599 -0.9345 1573675 TimTec1_000811 O=C(C1c2ccccc2Oc3ccccc13)N4CCCc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E20 compound treatment 61400.0 -26200.0 -0.43 55600.0 -51200.0 -0.82 -0.882 -0.9558 1156098 TimTec1_000812 NC1=C(C(=O)OCc2ccccc2)C3(C(=O)Nc4ccc(Br)cc43)C5=C(O1)C(=O)CCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E21 compound treatment 7920.0 -79600.0 -1.31 6080.0 -101000.0 -1.6 -2.0644 -0.9951 1774639 TimTec1_000813 [O-][n+]1onc2c3cc([nH]c3ccc12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E22 compound treatment 9320.0 -78200.0 -1.29 8360.0 -98400.0 -1.57 -2.0223 -0.9953 1601319 TimTec1_000814 CCOc1ccc(cc1)C2(C)CC(C)(C)Nc3ccccc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E23 mock treatment 121880.0 34300.0 0.57 94520.0 -12200.0 -0.2 0.2625 0.4382 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 E24 mock treatment 91440.0 3880.0 0.06 82200.0 -24600.0 -0.39 -0.2316 -0.5838 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F01 compound treatment 53680.0 -33900.0 -0.56 38040.0 -68700.0 -1.1 -1.17 -0.9513 3209085 TimTec1_000815 Oc1n[nH]c(c1C(C(C#N)C#N)c2ccsc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F02 compound treatment 76720.0 -10800.0 -0.18 88920.0 -17800.0 -0.28 -0.3277 -0.9751 1492048 TimTec1_000816 C(C1NCC=N1)c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F03 compound treatment 7840.0 -79700.0 -1.32 7400.0 -99400.0 -1.58 -2.0504 -0.9958 3209086 TimTec1_000817 O=c/1[nH]c2ccccc2[nH]\c1=N/C(=S)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F04 compound treatment 135720.0 48200.0 0.79 116280.0 9510.0 0.15 0.6693 0.8271 1173360 TimTec1_000818 COc1ccc(cc1OC)C(=O)NC(CO)(CO)CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F05 compound treatment 128320.0 40800.0 0.67 140840.0 34100.0 0.54 0.8598 0.9944 1399424 TimTec1_000819 C1C2C(Oc3ccccc3C2Oc4ccccc14)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F06 compound treatment 109200.0 21600.0 0.36 102800.0 -3970.0 -0.06 0.2079 0.5731 1110045 TimTec1_000820 CN(C1CCCCC1)S(=O)(=O)c2ccc(N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F07 compound treatment 124080.0 36500.0 0.6 110600.0 3830.0 0.06 0.4695 0.7748 3209087 TimTec1_000821 CC(C)C1=C2CCCCC2NC(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F08 compound treatment 127560.0 40000.0 0.66 100880.0 -5890.0 -0.09 0.4005 0.6006 1005088 TimTec1_000822 COC(=O)c1cc(C(=O)OC)c(cc1C(=O)OC)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F09 compound treatment 60800.0 -26800.0 -0.44 63920.0 -42800.0 -0.68 -0.7953 -0.9778 1428753 TimTec1_000823 CC(=O)Nc1ccc(cc1)S(=O)(=O)n2cnc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F10 compound treatment 120760.0 33200.0 0.55 104680.0 -2090.0 -0.03 0.364 0.663 1121309 TimTec1_000824 CCCC(=O)Nc1cccc(N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F11 compound treatment 14640.0 -72900.0 -1.2 10400.0 -96400.0 -1.54 -1.9372 -0.9927 1703558 TimTec1_000825 NC1=C(C#N)C2=CCCCC2C3(C(=O)N(Cc4ccccc4)c5ccccc53)C1(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F12 compound treatment 122440.0 34900.0 0.58 101640.0 -5130.0 -0.08 0.3493 0.6007 1304433 TimTec1_000826 CN(C)CC#CC1(O)CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F13 compound treatment 120080.0 32500.0 0.54 126840.0 20100.0 0.32 0.6058 0.9694 3209088 TimTec1_000827 CN(C)c1ccc(/C=C/2\CSC(=S)NC2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F14 compound treatment 130720.0 43200.0 0.71 124440.0 17700.0 0.28 0.7029 0.9176 3082476 TimTec1_000828 CC/1(OCO\C1=C/C[N+](C)(C)C)C=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F15 compound treatment 128480.0 40900.0 0.68 105680.0 -1090.0 -0.02 0.4654 0.6888 3209089 TimTec1_000829 COc1ccccc1CC(=O)N2CCCC(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F16 compound treatment 120080.0 32500.0 0.54 129240.0 22500.0 0.36 0.6328 0.9807 3082477 TimTec1_000830 C(=N/n1cnnc1)\c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F17 compound treatment 82880.0 -4680.0 -0.08 63080.0 -43700.0 -0.7 -0.547 -0.7808 1177709 TimTec1_000831 CCc1cc(c2n[nH]cc2c3nc(C)cs3)c(O)cc1OC(C)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F18 compound treatment 122760.0 35200.0 0.58 118760.0 12000.0 0.19 0.546 0.8927 3082478 TimTec1_000832 Cc1c(/N=C\C2CCCN3CCCCC23)c(=O)n(c4ccccc4)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F19 compound treatment 145280.0 57700.0 0.95 133000.0 26200.0 0.42 0.9694 0.9317 3209090 TimTec1_000833 COc1cc(Br)cc(CNc2cc(C)on2)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F20 compound treatment 149560.0 62000.0 1.02 117160.0 10400.0 0.17 0.8408 0.811 3209091 TimTec1_000834 O=C(/C=C/c1ccccc1)N2CCCCC2c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F21 compound treatment 79560.0 -8000.0 -0.13 52920.0 -53800.0 -0.86 -0.7003 -0.8064 3082479 TimTec1_000835 COc1ccc(NC(=S)SC)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F22 compound treatment 139720.0 52200.0 0.86 97040.0 -9730.0 -0.16 0.4992 0.5706 1375719 TimTec1_000836 CCCC1=C(C(NC(=O)N1)c2cc(Br)c(O)c(OC)c2)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F23 mock treatment 92320.0 4760.0 0.08 116320.0 9550.0 0.15 0.1632 0.9526 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 F24 mock treatment 110600.0 23000.0 0.38 81920.0 -24800.0 -0.4 -0.0111 -0.0203 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G01 compound treatment 94600.0 7040.0 0.12 75480.0 -31300.0 -0.5 -0.2705 -0.5282 1641121 TimTec1_000837 CCC(C)NC(=O)c1ccc(cc1)N(CC)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G02 compound treatment 64840.0 -22700.0 -0.38 50280.0 -56500.0 -0.9 -0.9018 -0.9247 1504788 TimTec1_000838 Clc1cccc(c1)c2nc3n(ncc3c(=O)o2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G03 compound treatment 116360.0 28800.0 0.48 137360.0 30600.0 0.49 0.6809 0.9999 1392995 TimTec1_000839 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G04 compound treatment 88240.0 678.0 0.01 104760.0 -2010.0 -0.03 -0.0147 -0.434 1261047 TimTec1_000840 O=C1NC(C(N1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G05 compound treatment 98600.0 11000.0 0.18 104800.0 -1970.0 -0.03 0.1067 0.577 3082481 TimTec1_000841 Sc1nccn1CCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G06 compound treatment 95880.0 8320.0 0.14 95120.0 -11600.0 -0.19 -0.0342 -0.148 1044409 TimTec1_000842 O=C(Nc1ccccc1)C(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G07 compound treatment 129840.0 42300.0 0.7 116880.0 10100.0 0.16 0.6075 0.8481 1679314 TimTec1_000843 NC(=O)C1C(C2CCC1C2)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G08 compound treatment 9600.0 -78000.0 -1.29 8440.0 -98300.0 -1.57 -2.0182 -0.9952 3082485 TimTec1_000844 Clc1ccc(/N=C/c2ccc(Br)o2)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G09 compound treatment 58640.0 -28900.0 -0.48 62520.0 -44200.0 -0.71 -0.8363 -0.982 1181154 TimTec1_000845 O=c1n(c(SCc2ccc3OCOc3c2)nc4ccccc14)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G10 compound treatment 101280.0 13700.0 0.23 101600.0 -5170.0 -0.08 0.1019 0.4229 3082487 TimTec1_000846 Cc1ccc(/N=C/c2cc3ccccc3nc2Cl)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G11 compound treatment 14200.0 -73400.0 -1.21 21480.0 -85300.0 -1.36 -1.8175 -0.9983 1384410 TimTec1_000847 CCCc1c(C(=O)OCC)c(C(=O)OCC)c2c(nc(nn12)N3CCOCC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G12 compound treatment 127160.0 39600.0 0.65 128680.0 21900.0 0.35 0.7092 0.9569 1271027 TimTec1_000848 COc1ccc(CC(=O)NCC(C)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G13 compound treatment 108200.0 20600.0 0.34 112600.0 5830.0 0.09 0.3066 0.8683 3209212 TimTec1_000849 Cc1ccc(/N=C/c2c[nH]c3ccccc23)nc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G14 compound treatment 98760.0 11200.0 0.18 88360.0 -18400.0 -0.29 -0.0767 -0.2213 1290233 TimTec1_000850 Brc1ccc(cc1)S(=O)(=O)N2CCCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G15 compound treatment 125560.0 38000.0 0.63 118720.0 12000.0 0.19 0.5782 0.8821 3209213 TimTec1_000851 CCCNc1nc(Cl)nc(NCCC)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G16 compound treatment 26000.0 -61600.0 -1.02 40200.0 -66600.0 -1.06 -1.4688 -0.9998 1275135 TimTec1_000852 O=S(=O)(N(c1ccccc1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G17 compound treatment 44440.0 -43100.0 -0.71 43360.0 -63400.0 -1.01 -1.2179 -0.9853 3209214 TimTec1_000853 NS(=O)(=O)c1ccc(/N=C/c2c(O)ccc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G18 compound treatment 99800.0 12200.0 0.2 79000.0 -27800.0 -0.44 -0.1701 -0.3496 3082492 TimTec1_000854 COc1ccc(OC)c(NS(=O)(=O)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G19 compound treatment 96560.0 9000.0 0.15 94600.0 -12200.0 -0.19 -0.0321 -0.1314 3209215 TimTec1_000855 Cc1cc(nn1CC(=O)Nc2sc(C)c(C)c2C(=O)N)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G20 compound treatment 121680.0 34100.0 0.56 121240.0 14500.0 0.23 0.5614 0.9224 1545537 TimTec1_000856 Cc1cc(C)c2oc(nc2c1)c3ccc(NC(=O)COc4ccc(Br)cc4)cc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G21 compound treatment 112000.0 24400.0 0.4 128360.0 21600.0 0.34 0.5286 0.9969 1150900 TimTec1_000857 On1c(nc-2c1CCc3nonc32)c4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G22 compound treatment 66600.0 -21000.0 -0.35 72400.0 -34400.0 -0.55 -0.632 -0.9755 3082530 TimTec1_000858 Cc1cc(C)c(C#N)c(SCc2cc(O)[nH]n2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G23 mock treatment 80040.0 -7520.0 -0.12 96240.0 -10500.0 -0.17 -0.2064 -0.989 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 G24 mock treatment 74200.0 -13400.0 -0.22 84080.0 -22700.0 -0.36 -0.4117 -0.9719 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H01 compound treatment 65080.0 -22500.0 -0.37 76560.0 -30200.0 -0.48 -0.6029 -0.9917 1198410 TimTec1_000859 Cc1[nH]nc(O)c1C2(C(C#N)C#N)C3CC4CC(C3)CC2C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H02 compound treatment 83520.0 -4040.0 -0.07 92040.0 -14700.0 -0.23 -0.2132 -0.8735 3209216 TimTec1_000860 Cc1ccc(OCc2nnc(S)n2c3ccccc3)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H03 compound treatment 90280.0 2720.0 0.04 115280.0 8510.0 0.14 0.1277 0.8933 1739416 TimTec1_000861 CCN(CC)c1[nH]nnc1c2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H04 compound treatment 125960.0 38400.0 0.63 126440.0 19700.0 0.31 0.6699 0.9473 3082533 TimTec1_000862 CCOC(=O)c1ccc(SC)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H05 compound treatment 71400.0 -16200.0 -0.27 82400.0 -24400.0 -0.39 -0.4633 -0.9832 1302286 TimTec1_000863 O=C(C1CC2CCC1C2)N3CCN(CC3)c4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H06 compound treatment 131920.0 44400.0 0.73 143520.0 36800.0 0.59 0.932 0.9939 1696584 TimTec1_000864 COc1ccc(cc1)C2OC(=O)c3ccccc3S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H07 compound treatment 63160.0 -24400.0 -0.4 66920.0 -39800.0 -0.64 -0.7339 -0.9759 1246999 TimTec1_000865 CC1C=C(C)C2C(C)C1(COC(=O)NC3CCCCC3)COC42CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H08 compound treatment 105720.0 18200.0 0.3 92200.0 -14600.0 -0.23 0.0478 0.126 3209217 TimTec1_000866 Sc1nnc(COc2ccccc2)n1CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H09 compound treatment 85640.0 -1920.0 -0.03 80960.0 -25800.0 -0.41 -0.3133 -0.7594 1579810 TimTec1_000867 Clc1ccc(cc1)C(=O)N2CCCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H10 compound treatment 114160.0 26600.0 0.44 128400.0 21600.0 0.34 0.5543 0.9929 1114790 TimTec1_000868 Cc1ccc(OCC(=O)O)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H11 compound treatment 49800.0 -37800.0 -0.62 51920.0 -54800.0 -0.87 -1.0589 -0.9863 1201078 TimTec1_000869 COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H12 compound treatment 118120.0 30600.0 0.5 123240.0 16500.0 0.26 0.5423 0.9537 1549339 TimTec1_000870 CC(O)(C#CCN1CCOCC1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H13 compound treatment 59840.0 -27700.0 -0.46 79400.0 -27400.0 -0.44 -0.632 -0.9997 3209218 TimTec1_000871 Clc1ccccc1/C=C/2\SC3NC(=NN3C2=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H14 compound treatment 122920.0 35400.0 0.58 130560.0 23800.0 0.38 0.6809 0.9782 3082538 TimTec1_000872 CC/1(C)OC(=O)N(\C1=C/C[N+](C)(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H15 compound treatment 107560.0 20000.0 0.33 112080.0 5310.0 0.08 0.2933 0.8607 1740713 TimTec1_000873 COc1ccccc1CC(=O)Nc2cccc(NC(=O)C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H16 compound treatment 115320.0 27800.0 0.46 131280.0 24500.0 0.39 0.6003 0.9969 1298167 TimTec1_000874 CC(=C1C(=O)NC(=O)NC1=O)c2ccc(N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H17 compound treatment 123560.0 36000.0 0.59 126200.0 19400.0 0.31 0.6392 0.9539 3209219 TimTec1_000875 Fc1ccc(cc1)S(=O)(=O)N(C2CCS(=O)(=O)C2)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H18 compound treatment 123120.0 35600.0 0.59 120960.0 14200.0 0.23 0.575 0.9141 1208196 TimTec1_000876 O=C(N1CC2CC(C1)c3cccc(=O)n3C2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H19 compound treatment 126520.0 39000.0 0.64 135960.0 29200.0 0.47 0.7837 0.9874 3082542 TimTec1_000877 CC(=O)NCCOc1c(C)cccc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H20 compound treatment 96320.0 8760.0 0.14 101400.0 -5370.0 -0.09 0.0417 0.2485 3082544 TimTec1_000878 COc1ccc(OCCSc2nc3ccccc3n2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H21 compound treatment 97600.0 10000.0 0.17 111280.0 4510.0 0.07 0.168 0.9302 1488809 TimTec1_000879 CC1CCCCN1S(=O)(=O)c2ccc(NC(=O)C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H22 compound treatment 99680.0 12100.0 0.2 120360.0 13600.0 0.22 0.2946 0.9992 1442845 TimTec1_000880 C(Sc1nc(c(o1)c2ccccc2)c3ccccc3)C4COc5ccccc5O4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H23 mock treatment 103440.0 15900.0 0.26 100160.0 -6610.0 -0.11 0.1109 0.3925 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 H24 mock treatment 32440.0 -55100.0 -0.91 83280.0 -23500.0 -0.37 -0.9081 -0.923 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I01 compound treatment 29760.0 -57800.0 -0.95 39440.0 -67300.0 -1.07 -1.4335 -0.9983 1191196 TimTec1_000881 Cc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I02 compound treatment 98400.0 10800.0 0.18 123720.0 17000.0 0.27 0.3176 0.9799 3082580 TimTec1_000882 O=c1oc(nc2sc3CCCCCc3c12)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I03 compound treatment 70200.0 -17400.0 -0.29 99080.0 -7690.0 -0.12 -0.2893 -0.9281 1319708 TimTec1_000883 Cc1cc(NC(=O)c2cccc(c2)S(=O)(=O)N3CCOCC3)no1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I04 compound treatment 91440.0 3880.0 0.06 140640.0 33900.0 0.54 0.427 0.7854 1427613 TimTec1_000884 Nc1ccc(cc1)C(C2NC(=O)c3ccccc23)c4ccc(N)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I05 compound treatment 16240.0 -71300.0 -1.18 19040.0 -87700.0 -1.4 -1.8212 -0.9963 1467312 TimTec1_000885 Cc1ccccc1NC(=O)CCC(=O)OC2CCC(CC2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I06 compound treatment 90040.0 2480.0 0.04 110600.0 3830.0 0.06 0.0721 0.9809 1018245 TimTec1_000886 CCN(CC)C(=O)C(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I07 compound treatment 118600.0 31000.0 0.51 111120.0 4350.0 0.07 0.4113 0.7956 1540337 TimTec1_000887 O=C(C1C(C#N)C2CCC1C2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I08 compound treatment 100520.0 13000.0 0.21 109840.0 3070.0 0.05 0.1859 0.8471 3082583 TimTec1_000888 OC(=O)c1ccccc1/N=C/c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I09 compound treatment 66440.0 -21100.0 -0.35 75160.0 -31600.0 -0.5 -0.6028 -0.9839 3209220 TimTec1_000889 Cn1c(SCc2ccc3OCOc3c2)nnc1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I10 compound treatment 119080.0 31500.0 0.52 114120.0 7350.0 0.12 0.4508 0.8452 3082586 TimTec1_000890 COC(=O)Nc1ccc(/N=C/c2cccs2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I11 compound treatment 9080.0 -78500.0 -1.3 10960.0 -95800.0 -1.53 -1.9958 -0.9967 3209221 TimTec1_000891 COc1nncc(n1)c2cnnc(SC)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I12 compound treatment 108280.0 20700.0 0.34 99680.0 -7090.0 -0.11 0.162 0.4497 1639601 TimTec1_000892 COc1ccc(CC(=O)NN2CCN(CC2)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I13 compound treatment 106320.0 18800.0 0.31 125120.0 18400.0 0.29 0.4258 0.9996 3209222 TimTec1_000893 C1CCC(=Nn2cnnc2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I14 compound treatment 50360.0 -37200.0 -0.61 67120.0 -39600.0 -0.63 -0.8811 -0.9999 1554764 TimTec1_000894 CN1CCN(CC1)S(=O)(=O)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I15 compound treatment 60000.0 -27600.0 -0.45 64880.0 -41900.0 -0.67 -0.7938 -0.9825 3209223 TimTec1_000895 CCOc1ccc2nc(/N=C/c3ccccc3O)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I16 compound treatment 61040.0 -26500.0 -0.44 80920.0 -25800.0 -0.41 -0.6009 -0.9995 1340130 TimTec1_000896 CC(=O)Nc1cccc(NS(=O)(=O)c2ccc(C)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I17 compound treatment 57880.0 -29700.0 -0.49 59600.0 -47200.0 -0.75 -0.878 -0.9785 1912630 TimTec1_000897 CCOC(=O)c1ccc(/N=C/c2ccccc2O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I18 compound treatment 109120.0 21600.0 0.36 126960.0 20200.0 0.32 0.4792 0.9987 1423694 TimTec1_000898 COC(=O)c1ccc(C(=O)OC)c(NC(=O)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I19 compound treatment 115200.0 27600.0 0.46 112040.0 5270.0 0.08 0.382 0.8235 3082591 TimTec1_000899 Nc1c(C#N)sc2nc(ccc12)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I20 compound treatment 120440.0 32900.0 0.54 109320.0 2550.0 0.04 0.4125 0.758 3209224 TimTec1_000900 CSc1ccc(/N=C/N2C(=O)c3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I21 compound treatment 99600.0 12000.0 0.2 114680.0 7910.0 0.13 0.2297 0.9759 3082593 TimTec1_000901 Oc1[nH]c(=S)[nH]c(=O)c1CN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I22 compound treatment 42920.0 -44600.0 -0.74 35920.0 -70800.0 -1.13 -1.3195 -0.9786 3209346 TimTec1_000902 O=C([C@H]1[C@H](c2cccs2)C(C#N)(C#N)[C@H]3N1C=Cc4ccccc34)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I23 mock treatment 95880.0 8320.0 0.14 115920.0 9150.0 0.15 0.2002 0.9995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 I24 mock treatment 60800.0 -26800.0 -0.44 77720.0 -29000.0 -0.46 -0.6397 -0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J01 compound treatment 97560.0 10000.0 0.17 142200.0 35400.0 0.56 0.516 0.8771 1633418 TimTec1_000903 Oc1cc(O)c2sc3nc(ccc3c2n1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J02 compound treatment 89280.0 1720.0 0.03 120400.0 13600.0 0.22 0.1737 0.7926 1297117 TimTec1_000904 Nc1ccc(cc1)c2cc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J03 compound treatment 81600.0 -5960.0 -0.1 107440.0 674.0 0.01 -0.062 -0.6262 3082596 TimTec1_000905 Sc1n[nH]nc1c2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J04 compound treatment 106880.0 19300.0 0.32 131520.0 24800.0 0.39 0.5045 0.9944 3209347 TimTec1_000906 CCOC(=O)c1ccc(cc1)S(=O)(=O)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J05 compound treatment 22000.0 -65600.0 -1.08 31400.0 -75400.0 -1.2 -1.6147 -0.9986 1207815 TimTec1_000907 CC1C=C(C)C2C(C)C1COC2c3ccccc3OCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J06 compound treatment 100240.0 12700.0 0.21 120520.0 13800.0 0.22 0.303 0.9997 1614670 TimTec1_000908 CC1CCCCN1S(=O)(=O)c2ccc(N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J07 compound treatment 30640.0 -56900.0 -0.94 36560.0 -70200.0 -1.12 -1.4557 -0.9962 1620705 TimTec1_000909 CC1CC2=C(CC1(CO)CO)C(C)(C)CCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J08 compound treatment 76280.0 -11300.0 -0.19 85560.0 -21200.0 -0.34 -0.3707 -0.9606 1432678 TimTec1_000910 Nc1cccc(c1)c2nc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J09 compound treatment 6360.0 -81200.0 -1.34 7680.0 -99100.0 -1.58 -2.0646 -0.9967 1679574 TimTec1_000911 Brc1ccc(cc1)C(=O)N2CCC(Cc3ccccc3)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J10 compound treatment 5800.0 -81800.0 -1.35 6880.0 -99900.0 -1.59 -2.0801 -0.9966 1513995 TimTec1_000912 CCCc1ccc(O)c(N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J11 compound treatment 21000.0 -66600.0 -1.1 21480.0 -85300.0 -1.36 -1.7381 -0.9944 1491173 TimTec1_000913 CC(=O)OC1CCC2(C)C3CCC4(C)C(CCC4=O)C3CC=C2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J12 compound treatment 84560.0 -3000.0 -0.05 107240.0 474.0 0.01 -0.0297 -0.5925 3082639 TimTec1_000914 OC1(CCCCC1)/C=C/CN2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J13 compound treatment 116360.0 28800.0 0.48 143240.0 36500.0 0.58 0.7472 0.995 3179906 TimTec1_000915 CC[C@]1(CCCN2CC[C@]3([C@H]4CC1)c5cccc(OC)c5N4C(=O)C)[C@@H]23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J14 compound treatment 72840.0 -14700.0 -0.24 107480.0 714.0 0.01 -0.1638 -0.6733 3082641 TimTec1_000916 CC1=[N+](CCC#N)c2ccccc2C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J15 compound treatment 61440.0 -26100.0 -0.43 67960.0 -38800.0 -0.62 -0.7423 -0.9845 1205123 TimTec1_000917 Cc1cccc(SCC(=O)Nc2ccc3OCCOc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J16 compound treatment 70400.0 -17200.0 -0.28 95680.0 -11100.0 -0.18 -0.3253 -0.9742 3082643 TimTec1_000918 SC(=S)N1CCCCC1c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J17 compound treatment 97880.0 10300.0 0.17 125280.0 18500.0 0.3 0.3291 0.9659 3209348 TimTec1_000919 CCOc1ccc(cc1)C(=O)CC(N)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J18 compound treatment 103640.0 16100.0 0.27 110680.0 3910.0 0.06 0.2318 0.8501 1146682 TimTec1_000920 O=C1N(CCN2CC3CC(C2)c4cccc(=O)n4C3)C(=O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J19 compound treatment 88720.0 1160.0 0.02 104720.0 -2050.0 -0.03 -0.0096 -0.2527 1708504 TimTec1_000921 NCCOc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J20 compound treatment 66480.0 -21100.0 -0.35 79640.0 -27100.0 -0.43 -0.5518 -0.9942 1179648 TimTec1_000922 CN(C)c1ccc(cc1)C2NC(=S)NC(=C2C(=O)OCCc3ccccc3)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J21 compound treatment 92560.0 5000.0 0.08 113240.0 6470.0 0.1 0.1313 0.9939 3082646 TimTec1_000923 NC(=N)SCc1csc(N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J22 compound treatment 9000.0 -78600.0 -1.3 9360.0 -97400.0 -1.55 -2.0148 -0.996 3082648 TimTec1_000924 C(Sc1cccc2cccnc12)c3nnc(o3)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J23 mock treatment 92520.0 4960.0 0.08 114760.0 7990.0 0.13 0.148 0.9771 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 J24 mock treatment 68600.0 -19000.0 -0.31 71760.0 -35000.0 -0.56 -0.6159 -0.9627 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K01 compound treatment 44600.0 -43000.0 -0.71 84120.0 -22600.0 -0.36 -0.7567 -0.9509 1262368 TimTec1_000925 CC(C)(C)NC(=O)CC(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K02 compound treatment 49160.0 -38400.0 -0.63 55440.0 -51300.0 -0.82 -1.0267 -0.9921 1207448 TimTec1_000926 CCc1nc2n(ncc2c(=O)n1CCc3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K03 compound treatment 37160.0 -50400.0 -0.83 54160.0 -52600.0 -0.84 -1.1812 -1.0 1458877 TimTec1_000927 COc1ccc(cc1S(=O)(=O)Nc2ccc(Cl)cc2)C(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K04 compound treatment 9360.0 -78200.0 -1.29 12840.0 -93900.0 -1.5 -1.9714 -0.9973 3082651 TimTec1_000928 COc1ccc(cc1N)S(=O)(=O)C=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K05 compound treatment 88040.0 478.0 0.01 109760.0 2990.0 0.05 0.0393 0.8129 3209349 TimTec1_000929 O=C1CCCC(Cn2cncn2)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K06 compound treatment 35080.0 -52500.0 -0.87 45320.0 -61400.0 -0.98 -1.3051 -0.9981 1111413 TimTec1_000930 O=C(N(c1ccccc1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K07 compound treatment 115840.0 28300.0 0.47 142320.0 35600.0 0.57 0.7308 0.9954 3082653 TimTec1_000931 CCC1=CC(NC(=S)N1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K08 compound treatment 39360.0 -48200.0 -0.8 52160.0 -54600.0 -0.87 -1.1781 -0.999 3209350 TimTec1_000932 Oc1ccccc1/C=N/c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K09 compound treatment 62400.0 -25200.0 -0.42 98480.0 -8290.0 -0.13 -0.3871 -0.8881 3082655 TimTec1_000933 CCc1ccc(OCCNC(=O)c2ccco2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K10 compound treatment 25840.0 -61700.0 -1.02 42760.0 -64000.0 -1.02 -1.4418 -1.0 1604140 TimTec1_000934 Clc1ccc(cc1)S(=O)(=O)N2CCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K11 compound treatment 76320.0 -11200.0 -0.19 94480.0 -12300.0 -0.2 -0.2697 -0.9996 1651876 TimTec1_000935 CNC(=O)CSc1c([nH]c2ccccc12)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K12 compound treatment 93640.0 6080.0 0.1 115440.0 8670.0 0.14 0.1687 0.9876 3082657 TimTec1_000936 Cc1onc(c1C(=O)NC2=NCCS2)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K13 compound treatment 79680.0 -7880.0 -0.13 94720.0 -12000.0 -0.19 -0.2278 -0.982 3209351 TimTec1_000937 Clc1ccc(/C=N\n2cnnc2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K14 compound treatment 51480.0 -36100.0 -0.6 77120.0 -29600.0 -0.47 -0.7553 -0.9934 1479829 TimTec1_000938 Brc1ccc(cc1)S(=O)(=O)NCC2CCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K15 compound treatment 34240.0 -53300.0 -0.88 40160.0 -66600.0 -1.06 -1.3731 -0.9957 3209352 TimTec1_000939 COc1ccc(/C=N/c2ccc(Br)cc2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K16 compound treatment 42600.0 -45000.0 -0.74 78680.0 -28100.0 -0.45 -0.8414 -0.9707 1308008 TimTec1_000940 CCN(c1ccccc1)S(=O)(=O)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K17 compound treatment 40320.0 -47200.0 -0.78 70920.0 -35800.0 -0.57 -0.9554 -0.9883 1918619 TimTec1_000941 CCOC(=O)c1ccc(/N=C/c2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K18 compound treatment 89680.0 2120.0 0.03 117560.0 10800.0 0.17 0.1464 0.8337 1453153 TimTec1_000942 COC(=O)c1cc(NC(=O)c2ccco2)cc(c1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K19 compound treatment 55280.0 -32300.0 -0.53 75320.0 -31400.0 -0.5 -0.7312 -0.9995 3209353 TimTec1_000943 Nc1nc2c3cc4CCCc4nc3sc2c(c1C#N)c5ccc(Br)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K20 compound treatment 86000.0 -1560.0 -0.03 124880.0 18100.0 0.29 0.1859 0.6414 1246610 TimTec1_000944 Cc1cccc(N2C(=O)c3ccc(cc3C2=O)C(=O)Nc4c[nH]c(=O)[nH]c4=O)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K21 compound treatment 55160.0 -32400.0 -0.53 69440.0 -37300.0 -0.59 -0.7989 -0.9986 1512817 TimTec1_000945 Cc1ccc(cc1)n2c(C)nc3sc4CCCc4c3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K22 compound treatment 64080.0 -23500.0 -0.39 91960.0 -14800.0 -0.24 -0.441 -0.9717 3209354 TimTec1_000946 NC(=O)C(C(C(C#N)C#N)c1ccccc1Cl)[n+]2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K23 mock treatment 87960.0 398.0 0.01 100800.0 -5970.0 -0.1 -0.0626 -0.6568 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 K24 mock treatment 58360.0 -29200.0 -0.48 122320.0 15600.0 0.25 -0.1656 -0.3054 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L01 compound treatment 3400.0 -84200.0 -1.39 5880.0 -101000.0 -1.61 -2.1194 -0.9973 1381598 TimTec1_000947 NC(=O)c1c(c(C#N)c(N)[nH]c1=S)c2cccc(Br)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L02 compound treatment 87080.0 -483.0 -0.01 114080.0 7310.0 0.12 0.0768 0.6573 1609999 TimTec1_000948 COC(=O)C1CCCN1S(=O)(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L03 compound treatment 80680.0 -6880.0 -0.11 140400.0 33600.0 0.54 0.2987 0.5451 1730347 TimTec1_000949 Cc1cccc(c1)C(=O)Nc2ccc3[nH]c(O)nc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L04 compound treatment 81720.0 -5840.0 -0.1 118720.0 12000.0 0.19 0.0665 0.3115 1111506 TimTec1_000950 OC(=O)CCc1ccc(F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L05 compound treatment 84360.0 -3200.0 -0.05 116920.0 10200.0 0.16 0.0771 0.4526 3209355 TimTec1_000951 FC(F)(F)c1cc(nc2c(Cl)c(nn12)C(=O)N3CCCc4ccccc34)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L06 compound treatment 93160.0 5600.0 0.09 118000.0 11200.0 0.18 0.1919 0.9526 1321261 TimTec1_000952 CC(CO)(CO)NS(=O)(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L07 compound treatment 28400.0 -59200.0 -0.98 38000.0 -68800.0 -1.1 -1.4656 -0.9983 3209356 TimTec1_000953 CCOC(=O)C1=C(N)n2c(=O)/c(=C\c3ccco3)/sc2=C(C1c4ccco4)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L08 compound treatment 12760.0 -74800.0 -1.23 25640.0 -81100.0 -1.29 -1.7874 -0.9997 1024363 TimTec1_000954 Nc1ccc(cc1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L09 compound treatment 88520.0 958.0 0.02 127320.0 20600.0 0.33 0.2428 0.7404 1663099 TimTec1_000955 CCN(C(=O)c1cccc(c1)C(=O)N(CC)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L10 compound treatment 108640.0 21100.0 0.35 141080.0 34300.0 0.55 0.6327 0.9762 1061459 TimTec1_000956 CN(c1ccccc1)S(=O)(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L11 compound treatment 93600.0 6040.0 0.1 113280.0 6510.0 0.1 0.1439 0.9998 1730887 TimTec1_000957 CCOC(=O)c1csc(N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L12 compound treatment 6360.0 -81200.0 -1.34 10240.0 -96500.0 -1.54 -2.0357 -0.9976 1709522 TimTec1_000958 O=C(OC1(CCCCC1)C#CCN2CCCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L13 compound treatment 36080.0 -51500.0 -0.85 40600.0 -66200.0 -1.05 -1.3466 -0.9943 1685514 TimTec1_000959 CCC1(CCCN2CCC3(C4CC1)c5ccc(OC)c(O)c5N4C(=O)C)C23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L14 compound treatment 21240.0 -66300.0 -1.09 34000.0 -72800.0 -1.16 -1.5942 -0.9996 1920479 TimTec1_000960 Oc1ccc(/C=N/c2nccs2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L15 compound treatment 33200.0 -54400.0 -0.9 50080.0 -56700.0 -0.9 -1.2734 -1.0 3082723 TimTec1_000961 CC(C)Cn1c(SCC(=O)c2ccc(Cl)cc2)nc3ccccc3c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L16 compound treatment 44040.0 -43500.0 -0.72 67120.0 -39600.0 -0.63 -0.9548 -0.998 3209357 TimTec1_000962 Oc1ccc(/C=N/CC2CCCN3CCCCC23)c(O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L17 compound treatment 51720.0 -35800.0 -0.59 103520.0 -3250.0 -0.05 -0.455 -0.766 3082725 TimTec1_000963 OC(=O)C(CC(=O)c1ccc(Cl)cc1)NC2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L18 compound treatment 75920.0 -11600.0 -0.19 117000.0 10200.0 0.16 -0.0206 -0.0816 1466736 TimTec1_000964 O=C1N(CCN2CCCCC2)C(=O)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L19 compound treatment 78040.0 -9520.0 -0.16 93920.0 -12800.0 -0.2 -0.2559 -0.9915 3082726 TimTec1_000965 CC(=O)NCCOc1ccccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L20 compound treatment 69280.0 -18300.0 -0.3 128480.0 21700.0 0.35 0.0313 0.0682 3209478 TimTec1_000966 COC(=O)C1=C(C)N(C)C(=O)NC1c2ccc(OC)c(Br)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L21 compound treatment 48800.0 -38800.0 -0.64 91840.0 -14900.0 -0.24 -0.6207 -0.9092 3082728 TimTec1_000967 COc1cccc(c1)c2csc3[nH]cnc(=O)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L22 compound treatment 57640.0 -29900.0 -0.49 94680.0 -12100.0 -0.19 -0.4855 -0.9157 1136019 TimTec1_000968 CN(C)c1ccc(cc1)C2NCC(CSc3nc4ccccc4s3)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L23 mock treatment 89120.0 1560.0 0.03 124520.0 17800.0 0.28 0.2183 0.7682 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 L24 mock treatment 70640.0 -16900.0 -0.28 114200.0 7430.0 0.12 -0.1137 -0.3749 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M01 compound treatment 37960.0 -49600.0 -0.82 89080.0 -17700.0 -0.28 -0.7783 -0.8988 1453808 TimTec1_000969 O=C(CC(c1ccccc1)c2ccccc2)NC3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M02 compound treatment 8080.0 -79500.0 -1.31 21960.0 -84800.0 -1.35 -1.8835 -0.9999 1706729 TimTec1_000970 Cc1csc(NC(=O)CSc2nc(ccc2C#N)C3(CC4CC5CC(C4)C3)C5)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M03 compound treatment 58720.0 -28800.0 -0.48 124720.0 18000.0 0.29 -0.1343 -0.2418 1282202 TimTec1_000971 CC1CN(CC(C)O1)S(=O)(=O)c2cccc(c2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M04 compound treatment 40360.0 -47200.0 -0.78 68880.0 -37900.0 -0.6 -0.978 -0.9921 3082794 TimTec1_000972 Nc1ccc(Cc2ccc(N)c(C#N)c2)cc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M05 compound treatment 41200.0 -46400.0 -0.77 70520.0 -36200.0 -0.58 -0.9497 -0.9904 3209479 TimTec1_000973 FC(F)(F)c1cc(nc2c(cnn12)C(=O)NCC=C)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M06 compound treatment 24520.0 -63000.0 -1.04 48160.0 -58600.0 -0.93 -1.3964 -0.9985 1356106 TimTec1_000974 CN(C)c1cc(O)c(C(=S)Nc2ccccc2)c(c1)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M07 compound treatment 30840.0 -56700.0 -0.94 69920.0 -36800.0 -0.59 -1.0774 -0.9747 1632278 TimTec1_000975 CC(Sc1ncnc2[nH]cnc12)c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M08 compound treatment 86240.0 -1320.0 -0.02 124480.0 17700.0 0.28 0.1842 0.6505 3082797 TimTec1_000976 COc1ccc(/C=N/c2ccccc2C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M09 compound treatment 72000.0 -15600.0 -0.26 131120.0 24400.0 0.39 0.0928 0.1994 3209480 TimTec1_000977 Cc1ccccc1OCCNC(=O)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M10 compound treatment 91760.0 4200.0 0.07 133040.0 26300.0 0.42 0.3451 0.8131 1332157 TimTec1_000978 COc1ccc(NC(=O)c2cccc(C)c2)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M11 compound treatment 52120.0 -35400.0 -0.59 86080.0 -20700.0 -0.33 -0.6468 -0.9632 3209481 TimTec1_000979 NNC(=O)CCCSc1nc2ccccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M12 compound treatment 97680.0 10100.0 0.17 124160.0 17400.0 0.28 0.3141 0.9706 3082799 TimTec1_000980 Cc1ccccc1C(=O)NC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M13 compound treatment 89960.0 2400.0 0.04 108800.0 2030.0 0.03 0.0509 0.9951 1494508 TimTec1_000981 Cc1ccc(NC(=O)n2ccnc2)cc1NC(=O)n3ccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M14 compound treatment 32760.0 -54800.0 -0.9 46920.0 -59800.0 -0.95 -1.3142 -0.9996 1306757 TimTec1_000982 CN(C1CCCCC1)S(=O)(=O)c2cc(Cl)ccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M15 compound treatment 20960.0 -66600.0 -1.1 33400.0 -73400.0 -1.17 -1.6043 -0.9995 3082802 TimTec1_000983 COc1ccc(/C=N/c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M16 compound treatment 25280.0 -62300.0 -1.03 34400.0 -72400.0 -1.15 -1.5426 -0.9984 1154044 TimTec1_000984 COc1ccc(cc1)S(=O)(=O)N2CCc3ccccc3C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M17 compound treatment 40960.0 -46600.0 -0.77 64440.0 -42300.0 -0.67 -1.021 -0.9979 3082804 TimTec1_000985 Fc1ccc(/C=N/c2ccc3ccccc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M18 compound treatment 45320.0 -42200.0 -0.7 68120.0 -38600.0 -0.62 -0.9286 -0.9981 1441763 TimTec1_000986 CCOC(=O)c1ccc(NC(=O)c2ccco2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M19 compound treatment 24400.0 -63200.0 -1.04 15560.0 -91200.0 -1.45 -1.7652 -0.9867 1358509 TimTec1_000987 CN1CCc2nc3sc(C(=O)C(C)(C)C)c(N)c3cc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M20 compound treatment 83120.0 -4440.0 -0.07 102720.0 -4050.0 -0.06 -0.0975 -0.9979 1432076 TimTec1_000988 Clc1ccc(NC(=O)CCN2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M21 compound treatment 76400.0 -11200.0 -0.18 122320.0 15600.0 0.25 0.045 0.1457 1556893 TimTec1_000989 CCOC(=O)c1cnn(c1NC(=O)C(C)(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M22 compound treatment 54120.0 -33400.0 -0.55 122160.0 15400.0 0.25 -0.2169 -0.359 3209482 TimTec1_000990 C[C@]1(O)NC(=C(C#N)C(C1[n+]2ccccc2)c3ccc(Cl)cc3)S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M23 mock treatment 88400.0 838.0 0.01 165040.0 58300.0 0.93 0.6665 0.7176 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 M24 mock treatment 72440.0 -15100.0 -0.25 132360.0 25600.0 0.41 0.1119 0.234 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N01 compound treatment 17040.0 -70500.0 -1.16 50960.0 -55800.0 -0.89 -1.4521 -0.9912 1633893 TimTec1_000991 Oc1cccc(c1)C2=NC(=O)c3ccccc3Nc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N02 compound treatment 43240.0 -44300.0 -0.73 124920.0 18200.0 0.29 -0.3128 -0.3975 1083978 TimTec1_000992 CCOC(=O)Nc1ccc(Cl)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N03 compound treatment 51240.0 -36300.0 -0.6 128560.0 21800.0 0.35 -0.1783 -0.2574 1379055 TimTec1_000993 CC(=O)OC1C2CCC1C(CC2)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N04 compound treatment 68480.0 -19100.0 -0.31 114600.0 7830.0 0.12 -0.1345 -0.3968 1041245 TimTec1_000994 NNC(=O)CCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N05 compound treatment 33240.0 -54300.0 -0.9 101400.0 -5370.0 -0.09 -0.6946 -0.7711 1709635 TimTec1_000995 O=C(Nc1ccccc1)OC2C3CCCC2C(CC3)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N06 compound treatment 44640.0 -42900.0 -0.71 121000.0 14200.0 0.23 -0.3406 -0.4578 1189065 TimTec1_000996 Cc1ccc(C)c(NS(=O)(=O)c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N07 compound treatment 37080.0 -50500.0 -0.83 89800.0 -17000.0 -0.27 -0.7805 -0.8908 1163480 TimTec1_000997 CC(=O)NC1C(=O)N(Cc2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N08 compound treatment 9800.0 -77800.0 -1.28 24400.0 -82400.0 -1.31 -1.836 -0.9999 1111758 TimTec1_000998 Nc1ccc(cc1)c2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N09 compound treatment 38560.0 -49000.0 -0.81 121040.0 14300.0 0.23 -0.4111 -0.4893 1140426 TimTec1_000999 CN(Cc1ccccc1)C(=O)c2cccc(c2)C(=O)N(C)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N10 compound treatment 37880.0 -49700.0 -0.82 102440.0 -4330.0 -0.07 -0.6287 -0.7639 1327404 TimTec1_001000 COc1ccc(cc1)C(=O)NC(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N11 compound treatment 46440.0 -41100.0 -0.68 74920.0 -31800.0 -0.51 -0.8389 -0.9897 3209483 TimTec1_001001 COCC(=O)Nc1cc(Sc2ccccc2)ccc1N=C(NC(=O)C)NC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N12 compound treatment 53400.0 -34200.0 -0.56 71360.0 -35400.0 -0.56 -0.7978 -1.0 1566798 TimTec1_001002 CCC(CC)(CN(C)C)OC(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N13 compound treatment 59920.0 -27600.0 -0.46 75280.0 -31500.0 -0.5 -0.6775 -0.9989 3209484 TimTec1_001003 CCCN1CC2(COC)CC[C@H](OC)[C@]3(CC[C@H](COC)[C@@H](O)C[C@@](C)(O)C4(O)[C@@H](OC)[C@@H]32)[C@@H]14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N14 compound treatment 31400.0 -56200.0 -0.93 60080.0 -46700.0 -0.74 -1.1817 -0.9941 3082877 TimTec1_001004 Clc1ccc(/C=N/c2ccccn2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N15 compound treatment 11120.0 -76400.0 -1.26 32920.0 -73800.0 -1.18 -1.7245 -0.9994 3082878 TimTec1_001005 OC(=O)C(CC(=O)c1ccc(cc1)C2CCCCC2)N3CCN(CC3)c4cccc(Cl)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N16 compound treatment 29240.0 -58300.0 -0.96 89160.0 -17600.0 -0.28 -0.8792 -0.8767 1649522 TimTec1_001006 O=C1NC(=O)C(CC2CCCN3CCCCC23)C(=O)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N17 compound treatment 35320.0 -52200.0 -0.86 102360.0 -4410.0 -0.07 -0.6595 -0.7622 3209485 TimTec1_001007 CN(C)/C=N/c1n[nH]c(Nc2ccc(C)c(C)c2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N18 compound treatment 46000.0 -41600.0 -0.69 115960.0 9190.0 0.15 -0.3815 -0.5438 1153859 TimTec1_001008 C[N+]12CCCCC2C(CN3C(=O)c4ccccc4C3=O)CCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N19 compound treatment 31160.0 -56400.0 -0.93 107200.0 434.0 0.01 -0.6535 -0.7018 3082882 TimTec1_001009 CC(=O)NCCOc1ccc(cc1)C2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N20 compound treatment 28000.0 -59600.0 -0.98 70840.0 -35900.0 -0.57 -1.1001 -0.9669 1577050 TimTec1_001010 CCc1ccc(cc1)C2C(=C(C)NC3=C2C(=O)CC(C)(C)C3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N21 compound treatment 69440.0 -18100.0 -0.3 116000.0 9230.0 0.15 -0.1075 -0.3223 3082884 TimTec1_001011 COC(=O)c1ccccc1N(C)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N22 compound treatment 22920.0 -64600.0 -1.07 51360.0 -55400.0 -0.88 -1.379 -0.9956 3209486 TimTec1_001012 CN(C)c1ccc(cc1)C2NCC(CSc3nc(cc(c3C#N)C(F)(F)F)c4cccs4)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N23 mock treatment 69800.0 -17800.0 -0.29 151080.0 44300.0 0.71 0.2921 0.382 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 N24 mock treatment 89720.0 2160.0 0.04 153400.0 46600.0 0.74 0.5508 0.7401 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O01 compound treatment 25240.0 -62300.0 -1.03 41800.0 -65000.0 -1.04 -1.4596 -1.0 1716121 TimTec1_001013 Clc1ccc(NC(=O)CC(c2ccccc2)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O02 compound treatment 32280.0 -55300.0 -0.91 49440.0 -57300.0 -0.91 -1.2914 -1.0 3209487 TimTec1_001014 CCOC(=O)C(C)Sc1nc(ccc1C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O03 compound treatment 31080.0 -56500.0 -0.93 80880.0 -25900.0 -0.41 -0.951 -0.9328 1595818 TimTec1_001015 O=S(=O)(NC1CCCCC1)c2cccc(c2)c3nnc(o3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O04 compound treatment 83720.0 -3840.0 -0.06 121160.0 14400.0 0.23 0.1174 0.4931 1004440 TimTec1_001016 COC(=O)c1ccc(cc1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O05 compound treatment 59120.0 -28400.0 -0.47 112440.0 5670.0 0.09 -0.268 -0.5606 1455776 TimTec1_001017 OC(=O)CCC(=O)Nc1ccc(Cc2ccncc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O06 compound treatment 78280.0 -9280.0 -0.15 130440.0 23700.0 0.38 0.1585 0.3891 3082886 TimTec1_001018 COC1OC(C)C(OCc2ccccc2)C(O)C1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O07 compound treatment 47840.0 -39700.0 -0.66 117480.0 10700.0 0.17 -0.3429 -0.5061 1682147 TimTec1_001019 CN(C)C(=O)CSc1nnc(N)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O08 compound treatment 53560.0 -34000.0 -0.56 113640.0 6870.0 0.11 -0.3194 -0.5585 3082888 TimTec1_001020 OC(=O)c1ccccc1/N=C/c2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O09 compound treatment 33280.0 -54300.0 -0.9 63440.0 -43300.0 -0.69 -1.1219 -0.9917 1398146 TimTec1_001021 O=C(CC1c2ccccc2Oc3ccccc13)Nc4ccccn4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O10 compound treatment 21720.0 -65800.0 -1.09 60560.0 -46200.0 -0.74 -1.2893 -0.982 3082890 TimTec1_001022 CCN(c1cccc(C)c1)c2ccccc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O11 compound treatment 35600.0 -52000.0 -0.86 52120.0 -54600.0 -0.87 -1.2224 -1.0 3209488 TimTec1_001023 NC1=NN(C(=O)C1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O12 compound treatment 77720.0 -9840.0 -0.16 100360.0 -6410.0 -0.1 -0.1871 -0.9749 1608079 TimTec1_001024 COc1ccc(cc1)C(=O)N(CC#N)CC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O13 compound treatment 87600.0 37.5 0.0 111480.0 4710.0 0.08 0.0536 0.7129 1340354 TimTec1_001025 CC(=O)Nc1ccc(cc1)S(=O)(=O)CCO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O14 compound treatment 41640.0 -45900.0 -0.76 60840.0 -45900.0 -0.73 -1.0536 -0.9998 1049845 TimTec1_001026 O=S(=O)(N1CCN(CC1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O15 compound treatment 27200.0 -60400.0 -1.0 70040.0 -36700.0 -0.59 -1.1185 -0.9679 3209489 TimTec1_001027 CC(=O)Nc1ccc(/N=C/c2cccc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O16 compound treatment 4520.0 -83000.0 -1.37 10400.0 -96400.0 -1.54 -2.0554 -0.9984 1685172 TimTec1_001028 CCc1ccc(NS(=O)(=O)c2ccc(OC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O17 compound treatment 14440.0 -73100.0 -1.21 32200.0 -74600.0 -1.19 -1.6939 -1.0 1709515 TimTec1_001029 CC(NC(=O)c1sc2nc(C)cc(C)c2c1N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O18 compound treatment 25040.0 -62500.0 -1.03 115880.0 9110.0 0.15 -0.6271 -0.6017 3209490 TimTec1_001030 NC1=C(C#N)C(c2cccc(F)c2)n3c(=O)/c(=C\c4cccc(F)c4)/sc3=C1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O19 compound treatment 10080.0 -77500.0 -1.28 21040.0 -85700.0 -1.37 -1.8706 -0.9995 1220431 TimTec1_001031 Cc1ccc(o1)C2C(=C(N)Oc3c2c(=O)oc4ccccc34)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O20 compound treatment 36240.0 -51300.0 -0.85 100880.0 -5890.0 -0.09 -0.6654 -0.7806 3209602 TimTec1_001032 CC1(C)NCCC21C(=O)N(Cc3ccccc3)c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O21 compound treatment 41440.0 -46100.0 -0.76 61080.0 -45700.0 -0.73 -1.0533 -0.9998 1707435 TimTec1_001033 CCN(CC)C(=O)c1c(NC(=O)c2cccs2)sc3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O22 compound treatment 56480.0 -31100.0 -0.51 110440.0 3670.0 0.06 -0.3214 -0.6224 1398816 TimTec1_001034 NC1=C(C#N)C(c2ccoc2)c3c([nH]nc3O1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O23 mock treatment 72680.0 -14900.0 -0.25 125600.0 18800.0 0.3 0.0385 0.0994 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 O24 mock treatment 83920.0 -3640.0 -0.06 138680.0 31900.0 0.51 0.3172 0.6192 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P01 compound treatment 38040.0 -49500.0 -0.82 41360.0 -65400.0 -1.04 -1.3152 -0.9928 1265807 TimTec1_001035 O=c1cc(c2ccccc2)n(cn1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P02 compound treatment 70120.0 -17400.0 -0.29 83200.0 -23600.0 -0.38 -0.4692 -0.9914 3209603 TimTec1_001036 CN1C2C(N=C1OCC=C)N(C)C(=O)N(C)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P03 compound treatment 20440.0 -67100.0 -1.11 41960.0 -64800.0 -1.03 -1.5139 -0.9994 1404718 TimTec1_001037 COc1cc(ccc1O)C2OCC3C(C)C=C(C)C2C3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P04 compound treatment 42360.0 -45200.0 -0.75 67480.0 -39300.0 -0.63 -0.9704 -0.9962 3082971 TimTec1_001038 CN1CN(C(=C1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P05 compound treatment 3680.0 -83900.0 -1.38 9920.0 -96800.0 -1.54 -2.0706 -0.9985 1591413 TimTec1_001039 CC1C=C(C)C2C(C)C1(COC(=O)Nc3ccccc3)COC2c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P06 compound treatment 53440.0 -34100.0 -0.56 112040.0 5270.0 0.08 -0.3389 -0.595 1353881 TimTec1_001040 C=CCC1(C2CCCC2)C(=O)NC(=O)NC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P07 compound treatment 2280.0 -85300.0 -1.41 5680.0 -101000.0 -1.61 -2.1347 -0.9977 3082974 TimTec1_001041 N(=c/1\[nH]n(c[n+]1c2ccccc2)c3ccccc3)\c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P08 compound treatment 21000.0 -66600.0 -1.1 42880.0 -63900.0 -1.02 -1.497 -0.9993 1117800 TimTec1_001042 Nc1ccc2oc(nc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P09 compound treatment 36360.0 -51200.0 -0.85 78560.0 -28200.0 -0.45 -0.9155 -0.9563 3209604 TimTec1_001043 CC1C2C(O)C3C(N(C)C)C(=C(C(=O)N)C(=O)C3(O)C(=C2Cc4c(O)cccc14)O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P10 compound treatment 34000.0 -53600.0 -0.88 61960.0 -44800.0 -0.71 -1.1302 -0.9944 1446940 TimTec1_001044 CCOc1ccc(cc1)C(=O)NC2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P11 compound treatment 21200.0 -66400.0 -1.1 29200.0 -77600.0 -1.24 -1.6488 -0.9982 3082976 TimTec1_001045 FC(F)(F)c1cccc(/N=C/c2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P12 compound treatment 39360.0 -48200.0 -0.8 69720.0 -37000.0 -0.59 -0.9802 -0.9892 3209605 TimTec1_001046 CC[N+](C)(CC)C/C=C\1/COCO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P13 compound treatment 44320.0 -43200.0 -0.71 87560.0 -19200.0 -0.31 -0.7212 -0.9286 1357190 TimTec1_001047 COc1ccc(CC(=O)N(CC#N)CC#N)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P14 compound treatment 26680.0 -60900.0 -1.01 63680.0 -43100.0 -0.69 -1.1962 -0.9828 3082979 TimTec1_001048 C1OCc2cccc(/C=N/c3nccs3)c2O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P15 compound treatment 44840.0 -42700.0 -0.71 72600.0 -34200.0 -0.54 -0.8837 -0.9918 3209606 TimTec1_001049 Cc1cc(C)nc(SCc2nc3ccccc3c(=O)n2c4ccc(cc4)C(F)(F)F)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P16 compound treatment 59880.0 -27700.0 -0.46 107680.0 914.0 0.01 -0.3128 -0.6842 2110705 TimTec1_001050 CN(C)c1ccc(/C=N/CC2CCCN3CCCCC23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P17 compound treatment 47880.0 -39700.0 -0.66 108120.0 1350.0 0.02 -0.4479 -0.6834 3082982 TimTec1_001051 OC(=O)C(CC(=O)c1ccc(Br)cc1)NCCc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P18 compound treatment 46400.0 -41200.0 -0.68 117560.0 10800.0 0.17 -0.3588 -0.5119 3209607 TimTec1_001052 OC(=O)c1cc(/C=N/c2ccc(cc2)S(=O)(=O)NC3NC=CS3)c4OCOCc4c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P19 compound treatment 52360.0 -35200.0 -0.58 74640.0 -32100.0 -0.51 -0.773 -0.998 1482831 TimTec1_001053 CN(c1cccc2cccnc12)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P20 compound treatment 47240.0 -40300.0 -0.67 88200.0 -18600.0 -0.3 -0.6799 -0.9334 1207395 TimTec1_001054 CC(C)COC(=O)C1=C(C)N(C)C(=O)NC1c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P21 compound treatment 15400.0 -72200.0 -1.19 14520.0 -92200.0 -1.47 -1.8819 -0.9945 3082984 TimTec1_001055 Cn1c(S)nc2sc3CC(CCc3c2c1=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P22 compound treatment 8200.0 -79400.0 -1.31 9320.0 -97400.0 -1.55 -2.0246 -0.9964 3209608 TimTec1_001056 CCN(CC)C(=S)C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P23 mock treatment 68400.0 -19200.0 -0.32 87440.0 -19300.0 -0.31 -0.4415 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2065 P24 mock treatment 77000.0 -10600.0 -0.17 59080.0 -47700.0 -0.76 -0.6607 -0.8473 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A01 compound treatment 30080.0 -50500.0 -0.83 32800.0 -40400.0 -0.64 -1.0443 -0.9919 3209609 TimTec1_001057 FC(F)(F)c1cc(NC(=O)C(=S)N2CCCCC2)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A02 compound treatment 78720.0 -1820.0 -0.03 38040.0 -35200.0 -0.56 -0.4175 -0.744 3082986 TimTec1_001058 CCN1C(=C(C#N)C2(CCNCC2)c3nc(C)oc13)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A03 compound treatment 73040.0 -7500.0 -0.12 43080.0 -30100.0 -0.48 -0.427 -0.8613 3082988 TimTec1_001059 Oc1cccc(/C=C\2/NC(=S)SC2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A04 compound treatment 6360.0 -74200.0 -1.22 3000.0 -70200.0 -1.12 -1.657 -0.999 3209610 TimTec1_001060 CCCc1nc2C(C(=C(N)Nc2o1)C#N)c3cnn(c3C)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A05 compound treatment 78400.0 -2140.0 -0.04 25880.0 -47300.0 -0.75 -0.5583 -0.7394 1135930 TimTec1_001061 O=C(NCCN1CCCCC1)Nc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A06 compound treatment 29720.0 -50800.0 -0.84 13880.0 -59300.0 -0.95 -1.2617 -0.9982 1680573 TimTec1_001062 COc1cc(OC)cc(c1)C(C(C#N)C#N)c2nc(C)[nH]c2O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A07 compound treatment 201040.0 120000.0 1.99 32360.0 -40800.0 -0.65 0.9463 0.4521 3209611 TimTec1_001063 CCOC(=O)C(N)Cc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A08 compound treatment 80720.0 179.0 0.0 24560.0 -48600.0 -0.78 -0.5461 -0.7044 1656439 TimTec1_001064 CCN(CC)C(=S)CSc1nc(cc(c2ccco2)c1C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A09 compound treatment 102600.0 22100.0 0.36 34280.0 -38900.0 -0.62 -0.1811 -0.2518 1709298 TimTec1_001065 COc1ccc2CCC(CC3(O)C(=O)N(C)c4ccccc43)C(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A10 compound treatment 151400.0 70900.0 1.17 37120.0 -36100.0 -0.58 0.4205 0.3226 1586331 TimTec1_001066 CC1=CC(c2ccoc2)c3c(S1)oc(N)c(C#N)c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A11 compound treatment 9280.0 -71300.0 -1.18 2840.0 -70400.0 -1.12 -1.6247 -0.9997 3083064 TimTec1_001067 Fc1ccc(CSC(=C(C#N)C#N)Nc2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A12 compound treatment 194280.0 114000.0 1.88 61480.0 -11700.0 -0.19 1.1956 0.6337 3209612 TimTec1_001068 CCCN1CC=C2C(C#N)(C#N)C(=C(C)[C@H](c3ccc(cc3)C(=O)OC)[C@@]2(C)C1)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A13 compound treatment 12400.0 -68100.0 -1.12 4440.0 -68800.0 -1.1 -1.5703 -0.9999 1679027 TimTec1_001069 CC(C)Oc1ccc(cc1)C2C(=C(N)N(c3oc(C)nc23)c4ccccc4)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A14 compound treatment 149480.0 68900.0 1.14 49080.0 -24100.0 -0.38 0.5329 0.4436 3209613 TimTec1_001070 CC(C)(C)C1CC=C2[C@H](C1)[C@H](C(=C(N)C2(C#N)C#N)C#N)c3ccsc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A15 compound treatment 135280.0 54700.0 0.9 42080.0 -31100.0 -0.5 0.2882 0.2796 3209614 TimTec1_001071 CN1C2CCC1[C@@H]3[C@H](C(=C(N)C(C#N)(C#N)C3=C2)C#N)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A16 compound treatment 127240.0 46700.0 0.77 40680.0 -32500.0 -0.52 0.1786 0.1923 1128630 TimTec1_001072 COc1cc(OC)cc(c1)C2SC(=C(C#N)C(=C2C#N)N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A17 compound treatment 190640.0 110000.0 1.82 42040.0 -31200.0 -0.5 0.934 0.4957 3083068 TimTec1_001073 COC(=O)C1=C(N)OC2=C(CCCC2=O)C1c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A18 compound treatment 203040.0 122000.0 2.02 73480.0 284.0 0.0 1.4331 0.7087 3209615 TimTec1_001074 Clc1cccc(c1)C(=O)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A19 compound treatment 174240.0 93700.0 1.55 54560.0 -18600.0 -0.3 0.8837 0.5611 1165075 TimTec1_001075 CCOC(=O)C1=C(S)N(C#N)C(=O)C(C#N)C21CCNCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A20 compound treatment 155000.0 74500.0 1.23 69600.0 -3600.0 -0.06 0.8286 0.6734 3083071 TimTec1_001076 CC(NC(=O)c1ccc(cc1)C(C)(C)C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A21 compound treatment 60000.0 -20500.0 -0.34 34840.0 -38400.0 -0.61 -0.672 -0.9613 1594569 TimTec1_001077 CCOC(=O)C1=C(N)OC(=C(C#N)C1c2ccccc2)c3cccc(OC)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A22 compound treatment 58440.0 -22100.0 -0.36 38120.0 -35100.0 -0.56 -0.6533 -0.9786 1190176 TimTec1_001078 CCOC(=O)C1CCCn2c1nc3sc4CCCCc4c3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A23 mock treatment 113920.0 33400.0 0.55 63560.0 -9640.0 -0.15 0.281 0.4913 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 A24 mock treatment 48040.0 -32500.0 -0.54 56600.0 -16600.0 -0.26 -0.5664 -0.9469 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B01 compound treatment 86240.0 5700.0 0.09 55560.0 -17600.0 -0.28 -0.1322 -0.4461 3209616 TimTec1_001079 O=c1oc(nc2scc(c3ccccc3)c12)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B02 compound treatment 59520.0 -21000.0 -0.35 53160.0 -20000.0 -0.32 -0.4712 -0.9991 1252791 TimTec1_001080 CC1(C)CC(=O)C2=C(C1)Nc3ccccc3N(C2c4ccco4)C(=S)Nc5cccc(Cl)c5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B03 compound treatment 157520.0 77000.0 1.27 85520.0 12300.0 0.2 1.0374 0.8068 3083074 TimTec1_001081 CCC(C)NC(=O)CSc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B04 compound treatment 113280.0 32700.0 0.54 62360.0 -10800.0 -0.17 0.26 0.4583 3083076 TimTec1_001082 O=C(CCCCn1cnc2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B05 compound treatment 138400.0 57900.0 0.96 74400.0 1200.0 0.02 0.6889 0.7212 1133090 TimTec1_001083 C1CC2=C(Nc3ncnn3C2c4ccccc4)c5ccccc5C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B06 compound treatment 166080.0 85500.0 1.41 112720.0 39500.0 0.63 1.4439 0.9339 1354657 TimTec1_001084 CC1CN(C)C(C(C)C21NC(=O)NC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B07 compound treatment 152280.0 71700.0 1.18 37640.0 -35600.0 -0.57 0.4366 0.3326 3083078 TimTec1_001085 Clc1cnn(Cc2ccccc2)c(=S)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B08 compound treatment 185520.0 105000.0 1.73 57920.0 -15300.0 -0.24 1.0532 0.6018 3209617 TimTec1_001086 OC(=O)[C@H]1NC(=O)C1Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B09 compound treatment 38120.0 -42400.0 -0.7 5800.0 -67400.0 -1.07 -1.2547 -0.9785 1612069 TimTec1_001087 Nc1sc2CCCc2c1C(=O)Nc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B10 compound treatment 113920.0 33400.0 0.55 31320.0 -41900.0 -0.67 -0.0823 -0.0951 3083081 TimTec1_001088 CC/1=NN(C(=O)\C1=C\2/C(=O)Nc3ccccc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B11 compound treatment 135960.0 55400.0 0.91 50120.0 -23100.0 -0.37 0.3868 0.3923 1674088 TimTec1_001089 Nn1c(nc2ccccc2c1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B12 compound treatment 114280.0 33700.0 0.56 77240.0 4040.0 0.06 0.4394 0.7837 1517968 TimTec1_001090 O=C(N1CCc2ccccc12)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B13 compound treatment 7800.0 -72700.0 -1.2 4000.0 -69200.0 -1.1 -1.6289 -0.9991 1537974 TimTec1_001091 Nc1sc2CCCCCc2c1C(=O)Nc3cccc(Cl)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B14 compound treatment 170520.0 90000.0 1.49 90920.0 17700.0 0.28 1.25 0.8268 3083084 TimTec1_001092 CCCNC(=O)Cn1nc(cc1C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B15 compound treatment 158520.0 78000.0 1.29 41920.0 -31300.0 -0.5 0.5577 0.404 3209740 TimTec1_001093 Cc1cc(Br)c(NC(=O)C2C(C)(C)C2(C)C)c(Br)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B16 compound treatment 105880.0 25300.0 0.42 33200.0 -40000.0 -0.64 -0.155 -0.2033 1410434 TimTec1_001094 CC(C)(C)c1nc2ccccc2c(=O)n1c3ccc(F)cc3F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B17 compound treatment 80200.0 -341.0 -0.01 31000.0 -42200.0 -0.67 -0.4795 -0.713 3083156 TimTec1_001095 CCOC(=O)c1ccc(/N=C/c2ccc(CC)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B18 compound treatment 148080.0 67500.0 1.11 42560.0 -30600.0 -0.49 0.4431 0.364 1578203 TimTec1_001096 Fc1ccc(NC(=O)CCC(=O)N(Cc2ccccc2)Cc3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B19 compound treatment 153840.0 73300.0 1.21 51680.0 -21500.0 -0.34 0.6131 0.4875 3083160 TimTec1_001097 CC(=O)Nc1nonc1/N=C\c2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B20 compound treatment 177200.0 96700.0 1.6 85360.0 12200.0 0.19 1.2653 0.7872 1344731 TimTec1_001098 Fc1ccc(CNC(=O)c2ccccc2C(=O)Cc3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B21 compound treatment 178520.0 98000.0 1.62 72960.0 -236.0 0.0 1.141 0.7055 1376655 TimTec1_001099 COc1cc(SC)ccc1C(=O)NC2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B22 compound treatment 56400.0 -24100.0 -0.4 47360.0 -25800.0 -0.41 -0.573 -0.9999 3209741 TimTec1_001100 Oc1ccc(cc1)C(=O)N2Cc3ccccc3N=C2S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B23 mock treatment 133480.0 52900.0 0.87 77720.0 4520.0 0.07 0.6689 0.7629 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 B24 mock treatment 112240.0 31700.0 0.52 48400.0 -24800.0 -0.4 0.0905 0.1381 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C01 compound treatment 28720.0 -51800.0 -0.86 18720.0 -54500.0 -0.87 -1.2188 -1.0 3209742 TimTec1_001101 Cc1cccc(NC(=O)CSc2nsc(SCC(=O)Nc3cccc(C)c3)c2C#N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C02 compound treatment 53360.0 -27200.0 -0.45 33800.0 -39400.0 -0.63 -0.7613 -0.9864 3083163 TimTec1_001102 CCN(CC)c1cc(nc(SCC(=O)c2cccs2)c1C#N)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C03 compound treatment 150920.0 70400.0 1.16 68080.0 -5120.0 -0.08 0.7638 0.6559 3083164 TimTec1_001103 N=c1sc2ccccc2n1C(=O)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C04 compound treatment 12080.0 -68500.0 -1.13 7520.0 -65700.0 -1.05 -1.5393 -0.9993 3209743 TimTec1_001104 COc1cccc(c1)[C@@H]2[C@H](N3C=Cc4ccccc4[C@@H]3C2(C#N)C#N)c5ccc(OC)c(F)c5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C05 compound treatment 153000.0 72500.0 1.2 119160.0 46000.0 0.73 1.3638 0.9723 1213390 TimTec1_001105 O=C(CSC1OC2C=CC=CC2=N1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C06 compound treatment 123080.0 42500.0 0.7 79280.0 6080.0 0.1 0.5651 0.7972 3209744 TimTec1_001106 CC1CC(=O)C2=C(O1)OC(=C(C#N)C2c3ccccc3C(F)(F)F)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C07 compound treatment 141280.0 60700.0 1.0 66200.0 -7000.0 -0.11 0.6301 0.6246 1713226 TimTec1_001107 COc1cc2ccc(=O)oc2c(OC3OC(CO)C(O)C(O)C3O)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C08 compound treatment 9400.0 -71100.0 -1.17 4200.0 -69000.0 -1.1 -1.608 -0.9995 3083167 TimTec1_001108 Cc1ccc(CSc2nc(ccc2C#N)C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C09 compound treatment 141960.0 61400.0 1.01 56080.0 -17100.0 -0.27 0.524 0.4991 3209745 TimTec1_001109 COc1cc(cc(OC)c1OC)c2c(C#N)c(SCC#N)nc(N)c2C(=O)OC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C10 compound treatment 139320.0 58800.0 0.97 64480.0 -8720.0 -0.14 0.5879 0.5997 3083169 TimTec1_001110 CCc1ccc(cc1)[C@@H]2[C@H]3CN(CC=C3C(C#N)(C#N)C(=C2C#N)N)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C11 compound treatment 10000.0 -70500.0 -1.16 4560.0 -68600.0 -1.09 -1.5969 -0.9995 3209746 TimTec1_001111 Fc1cccc(CSC(=C(C#N)C#N)Nc2ccccc2Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C12 compound treatment 137720.0 57200.0 0.94 90360.0 17200.0 0.27 0.8609 0.876 3209747 TimTec1_001112 COC(=O)C1=C(N)OC2=C(C1c3ccc(cc3)C(=O)OC)C(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C13 compound treatment 9160.0 -71400.0 -1.18 6680.0 -66500.0 -1.06 -1.5828 -0.9986 1123898 TimTec1_001113 COC(=O)[C@@]1(C#N)C([C@@H](C#N)N2[C@@H]1C=Cc3ccccc23)c4cc(OC)cc(OC)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C14 compound treatment 43600.0 -36900.0 -0.61 22040.0 -51200.0 -0.82 -1.0077 -0.9898 1317642 TimTec1_001114 COc1ccc(cc1)c2cc(SCCN3CCOCC3)c(C#N)c(n2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C15 compound treatment 70680.0 -9860.0 -0.16 35960.0 -37200.0 -0.59 -0.5348 -0.869 3083174 TimTec1_001115 CCOC(=O)C1=C(N)SC(=C(C#N)C1c2ccco2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C16 compound treatment 18400.0 -62100.0 -1.03 4040.0 -69200.0 -1.1 -1.5047 -0.9994 1197248 TimTec1_001116 Cc1cc2CC(=C(C#N)C(c3cccc(COc4ccccc4Cl)c3)c2c(=O)o1)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C17 compound treatment 9880.0 -70700.0 -1.17 3440.0 -69800.0 -1.11 -1.611 -0.9997 3209748 TimTec1_001117 CCOC(=O)C1=C(OC(=C(C#N)C1c2ccc(cc2)c3ccccc3)N)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C18 compound treatment 116880.0 36300.0 0.6 34360.0 -38800.0 -0.62 -0.0135 -0.0157 3083176 TimTec1_001118 CC1CCN(CC1)C(=O)c2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C19 compound treatment 9960.0 -70600.0 -1.17 4440.0 -68800.0 -1.1 -1.5987 -0.9995 3209749 TimTec1_001119 CC1=C(C#N)C(C2=C(CC(CC2=O)c3ccc(Br)cc3)O1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C20 compound treatment 121760.0 41200.0 0.68 74440.0 1240.0 0.02 0.4951 0.7274 3083178 TimTec1_001120 CC(=O)NC(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C21 compound treatment 123520.0 43000.0 0.71 63640.0 -9560.0 -0.15 0.394 0.5429 3209750 TimTec1_001121 COc1ccc(cc1OC)C(=O)COC2=C(C#N)C3(CCCC3)C(C#N)C(=S)N2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C22 compound treatment 90000.0 9460.0 0.16 58640.0 -14600.0 -0.23 -0.0536 -0.1918 3083180 TimTec1_001122 C1CCc2c(C1)sc3ncnc(Sc4ccccc4)c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C23 mock treatment 104720.0 24200.0 0.4 77400.0 4200.0 0.07 0.3296 0.8144 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 C24 mock treatment 75320.0 -5220.0 -0.09 57480.0 -15700.0 -0.25 -0.2381 -0.8987 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D01 compound treatment 83320.0 2780.0 0.05 66360.0 -6840.0 -0.11 -0.0446 -0.3774 1699716 TimTec1_001123 CCc1nc2sc(C)c(C)c2c(=O)n1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D02 compound treatment 106840.0 26300.0 0.43 70640.0 -2560.0 -0.04 0.2782 0.6379 3209751 TimTec1_001124 CC1(C)C(C(=O)NN2C(=O)c3ccccc3C2=O)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D03 compound treatment 120080.0 39500.0 0.65 93840.0 20600.0 0.33 0.6942 0.9497 3082090 TimTec1_001125 CC(C)(C)NC(=O)CSc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D04 compound treatment 120640.0 40100.0 0.66 82000.0 8800.0 0.14 0.5673 0.8384 1162107 TimTec1_001126 CC(C)N1CCC2(CC1)C(=C(O)NC3=C2C(=O)CC(C)(C)C3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D05 compound treatment 125320.0 44800.0 0.74 88840.0 15600.0 0.25 0.699 0.896 3209752 TimTec1_001127 COc1ccc(cc1)N2Cc3ccccc3C4(CCOCC4)C2=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D06 compound treatment 98880.0 18300.0 0.3 64680.0 -8520.0 -0.14 0.1181 0.3559 3209753 TimTec1_001128 COc1ccc(/N=C(\C)/c2c([nH]n(c3nc4ccccc4s3)c2=O)C(F)(F)F)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D07 compound treatment 128120.0 47600.0 0.79 83680.0 10500.0 0.17 0.6735 0.8388 1727579 TimTec1_001129 Clc1c(NCC2CCCO2)cnn(Cc3ccccc3)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D08 compound treatment 66320.0 -14200.0 -0.23 34120.0 -39100.0 -0.62 -0.6064 -0.9111 3082095 TimTec1_001130 Cc1ccc(cc1)C2=NNC(=S)C3=CNc4ccccc4N23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D09 compound treatment 54640.0 -25900.0 -0.43 28880.0 -44300.0 -0.71 -0.8018 -0.9711 1199669 TimTec1_001131 CCOc1ccc(NC(=O)c2c(N)sc3CCCc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D10 compound treatment 119600.0 39100.0 0.64 73520.0 324.0 0.01 0.4596 0.7127 1714748 TimTec1_001132 NC(=O)CSc1nc2CC3=C(CCC3)c2c(=O)n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D11 compound treatment 132720.0 52200.0 0.86 73360.0 164.0 0.0 0.6109 0.7092 1348333 TimTec1_001133 O=c1oc(nc2ccccc12)c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D12 compound treatment 32600.0 -47900.0 -0.79 16360.0 -56800.0 -0.91 -1.2001 -0.9977 1118692 TimTec1_001134 O=C(N1CCCc2ccccc12)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D13 compound treatment 110600.0 30100.0 0.5 86200.0 13000.0 0.21 0.4974 0.925 1352264 TimTec1_001135 CN(C)C(=O)c1c(NC(=O)c2ccc(C)cc2)sc3CCCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D14 compound treatment 96120.0 15600.0 0.26 41840.0 -31400.0 -0.5 -0.1716 -0.3052 3209754 TimTec1_001136 CCc1c(C)sc(NC(=O)/C=C/c2ccc(F)cc2)c1C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D15 compound treatment 140400.0 59900.0 0.99 64560.0 -8640.0 -0.14 0.6014 0.6028 3082099 TimTec1_001137 C=CC[n+]1ccc2ccccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D16 compound treatment 114920.0 34400.0 0.57 27400.0 -45800.0 -0.73 -0.1149 -0.1242 3209755 TimTec1_001138 FC(F)(F)c1cccc(c1)C(=O)Oc2ccc(cc2)C3SCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D17 compound treatment 89120.0 8580.0 0.14 46080.0 -27100.0 -0.43 -0.2055 -0.4518 3082101 TimTec1_001139 CCOc1ccc2ccccc2c1/C=N/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D18 compound treatment 20840.0 -59700.0 -0.99 5760.0 -67400.0 -1.07 -1.4569 -0.9991 1260565 TimTec1_001140 Clc1ccc(NC(=O)CN2CCCc3ccccc23)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D19 compound treatment 168280.0 87700.0 1.45 94520.0 21300.0 0.34 1.2644 0.85 1408681 TimTec1_001141 NNC(=O)c1cccc(Cn2cccn2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D20 compound treatment 94400.0 13900.0 0.23 29400.0 -43800.0 -0.7 -0.3318 -0.4517 3209756 TimTec1_001142 CC(C)Cn1c(=O)c2ccccc2[nH]c1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D21 compound treatment 123200.0 42700.0 0.7 74040.0 844.0 0.01 0.5074 0.7205 1521586 TimTec1_001143 Cc1ccccc1OCc2nnc(SCC(=O)N)n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D22 compound treatment 96120.0 15600.0 0.26 63560.0 -9640.0 -0.15 0.0732 0.2445 3209757 TimTec1_001144 COc1ccc(/C=N/C2=NNC(=O)C(CC(=O)O)S2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D23 mock treatment 118680.0 38100.0 0.63 70480.0 -2720.0 -0.04 0.4146 0.6569 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 D24 mock treatment 85600.0 5060.0 0.08 58480.0 -14700.0 -0.23 -0.1068 -0.429 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E01 compound treatment 85240.0 4700.0 0.08 46320.0 -26900.0 -0.43 -0.2481 -0.5698 1632993 TimTec1_001145 NC(=O)c1cnn2c(N)c(C#N)cnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E02 compound treatment 130320.0 49800.0 0.82 46640.0 -26600.0 -0.42 0.2817 0.3048 1454243 TimTec1_001146 CC(C)OC(=O)C1=C(C)SC(=C(C#N)C1c2ccc(cc2)C(C)C)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E03 compound treatment 14160.0 -66400.0 -1.1 9000.0 -64200.0 -1.02 -1.4983 -0.9994 3082105 TimTec1_001147 COc1cc(/C=N\C2=NN(CC2)c3ccccc3)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E04 compound treatment 7320.0 -73200.0 -1.21 4840.0 -68400.0 -1.09 -1.6251 -0.9987 3209876 TimTec1_001148 C[C@@H]1[C@H](N2C=Cc3ccccc3[C@@H]2C1(C#N)C#N)c4ccc(F)c(Br)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E05 compound treatment 36040.0 -44500.0 -0.73 23040.0 -50200.0 -0.8 -1.0847 -0.9991 1448274 TimTec1_001149 Cc1ccc2cccc(SC(=O)NCC3CCCO3)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E06 compound treatment 106080.0 25500.0 0.42 62360.0 -10800.0 -0.17 0.176 0.3863 3082108 TimTec1_001150 NC1=C(C#N)C(C2=C(O1)C(=O)CCC2)c3ccccc3C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E07 compound treatment 126960.0 46400.0 0.77 74360.0 1160.0 0.02 0.5549 0.724 1046360 TimTec1_001151 CC(=O)OCC1OC(C(OC(=O)C)C1OC(=O)C)n2ccc(=O)[nH]c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E08 compound treatment 9200.0 -71300.0 -1.18 4680.0 -68500.0 -1.09 -1.6049 -0.9993 1129068 TimTec1_001152 CN1CCc2c(nc(OCc3ccccc3Br)c(C#N)c2C1)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E09 compound treatment 79840.0 -701.0 -0.01 38800.0 -34400.0 -0.55 -0.3958 -0.7219 3082110 TimTec1_001153 CSc1nc(SCC(=O)c2ccc3OCOc3c2)nc(N)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E10 compound treatment 29800.0 -50700.0 -0.84 12080.0 -61100.0 -0.97 -1.2811 -0.9972 1730487 TimTec1_001154 Cc1nc(C(=O)N)c(NCC=C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E11 compound treatment 129280.0 48700.0 0.8 75840.0 2640.0 0.04 0.5987 0.7431 1334043 TimTec1_001155 COc1cc2CCN(Cc2cc1OC)C(=O)Cn3c(C)cc(C)c(C#N)c3=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E12 compound treatment 8600.0 -71900.0 -1.19 5360.0 -67800.0 -1.08 -1.6043 -0.9989 1513685 TimTec1_001156 O=C(c1ccccc1)[C@@]2(C[C@@H](C#N)N3[C@@H]2C=Cc4ccccc34)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E13 compound treatment 37200.0 -43300.0 -0.72 32960.0 -40200.0 -0.64 -0.9594 -0.9985 1696559 TimTec1_001157 CCN(CC)c1c(C#N)c(SCC(=O)c2cccs2)cc3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E14 compound treatment 7920.0 -72600.0 -1.2 5160.0 -68000.0 -1.08 -1.6144 -0.9987 3209877 TimTec1_001158 CCOC(=O)N1CC=C2C(C1)C(C(=C(N)C2(C#N)C#N)C#N)c3cccc(c3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E15 compound treatment 8200.0 -72300.0 -1.19 4400.0 -68800.0 -1.1 -1.6197 -0.9991 1628055 TimTec1_001159 OC(=O)c1ccc(cc1)c2cc(c3cccs3)c(C#N)c(SCc4cccs4)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E16 compound treatment 60960.0 -19600.0 -0.32 40120.0 -33100.0 -0.53 -0.6013 -0.9724 1516512 TimTec1_001160 CC1=C(C(C(=C(S)S1)C#N)c2ccc[nH]2)C(=O)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E17 compound treatment 87640.0 7100.0 0.12 48080.0 -25100.0 -0.4 -0.2002 -0.48 1382001 TimTec1_001161 COc1cc(OC)cc(c1)C2C(=C(N)Nc3oc(C)nc23)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E18 compound treatment 117960.0 37400.0 0.62 60400.0 -12800.0 -0.2 0.2925 0.4497 3082493 TimTec1_001162 CC(C)(C)c1ccc(cc1)C(=O)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E19 compound treatment 107760.0 27200.0 0.45 60200.0 -13000.0 -0.21 0.1712 0.3461 3082494 TimTec1_001163 FC(F)(F)c1cc(c2cccs2)c(C#N)c(S)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E20 compound treatment 124760.0 44200.0 0.73 74000.0 804.0 0.01 0.5252 0.7194 3209878 TimTec1_001164 CC1(C)C(C(=O)Nc2ccccc2C(F)(F)F)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E21 compound treatment 25600.0 -54900.0 -0.91 16080.0 -57100.0 -0.91 -1.285 -1.0 3209879 TimTec1_001165 CC(C)N1C/C(=C\c2ccccc2)/C(=O)\C(=C/c3ccccc3)\C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E22 compound treatment 7360.0 -73200.0 -1.21 5000.0 -68200.0 -1.09 -1.6228 -0.9986 1473801 TimTec1_001166 CCOC(=O)c1c(N)sc2c(OCC)c(Br)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E23 mock treatment 91800.0 11300.0 0.19 69080.0 -4120.0 -0.07 0.085 0.4314 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 E24 mock treatment 81760.0 1220.0 0.02 50360.0 -22800.0 -0.36 -0.2431 -0.667 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F01 compound treatment 103320.0 22800.0 0.38 68480.0 -4720.0 -0.08 0.2127 0.5548 1148234 TimTec1_001167 Cc1sc(NC(=O)c2ccccc2)c(C(=O)N3CCCCC3)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F02 compound treatment 80760.0 219.0 0.0 61200.0 -12000.0 -0.19 -0.1326 -0.6936 3082495 TimTec1_001168 NCc1c[nH]nc1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F03 compound treatment 50080.0 -30500.0 -0.5 35560.0 -37600.0 -0.6 -0.7797 -0.9962 3082496 TimTec1_001169 CCCCC(=O)c1ccc(C)[nH]c1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F04 compound treatment 130400.0 49900.0 0.82 81760.0 8560.0 0.14 0.6785 0.8133 3209880 TimTec1_001170 FC(F)(F)c1cc([nH]c(=S)c1C#N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F05 compound treatment 124920.0 44400.0 0.73 96040.0 22800.0 0.36 0.7755 0.9479 1552345 TimTec1_001171 OC1CS(=O)(=O)CC1NCc2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F06 compound treatment 125720.0 45200.0 0.75 96360.0 23200.0 0.37 0.7884 0.9474 3209881 TimTec1_001172 Cn1ncc(Br)c1c2nc3ccccc3[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F07 compound treatment 100200.0 19700.0 0.32 70160.0 -3040.0 -0.05 0.1952 0.5951 1231705 TimTec1_001173 Clc1c(NCCc2ccccc2)cnn(c3ccccc3)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F08 compound treatment 40720.0 -39800.0 -0.66 28880.0 -44300.0 -0.71 -0.9643 -0.9994 3082497 TimTec1_001174 COc1ccc(cc1)C2=NNC(=S)C3=CNc4ccccc4N23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F09 compound treatment 81400.0 859.0 0.01 37520.0 -35700.0 -0.57 -0.3921 -0.6893 1268647 TimTec1_001175 O=C(Nc1ccccc1)c2c(NC(=O)c3ccccc3)sc4CCCCc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F10 compound treatment 89520.0 8980.0 0.15 55160.0 -18000.0 -0.29 -0.0985 -0.3045 1547144 TimTec1_001176 CC(NC(=O)CSc1nc2CC3=C(CCCC3)c2c(=O)n1C)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F11 compound treatment 9880.0 -70700.0 -1.17 6560.0 -66600.0 -1.06 -1.5758 -0.9989 1204419 TimTec1_001177 CC1CCc2c(C(=O)Nc3ccc(Cl)cc3)c(N)sc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F12 compound treatment 119320.0 38800.0 0.64 92640.0 19400.0 0.31 0.6718 0.9446 1256297 TimTec1_001178 C(Cc1ccco1)C2NCCn3cccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F13 compound treatment 104960.0 24400.0 0.4 86080.0 12900.0 0.21 0.4302 0.951 1201070 TimTec1_001179 CCOC(=O)c1c(NC(=O)C)sc2CCCCCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F14 compound treatment 85640.0 5100.0 0.08 54200.0 -19000.0 -0.3 -0.1546 -0.4919 1590373 TimTec1_001180 CC(NC(=O)CC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F15 compound treatment 129360.0 48800.0 0.81 79280.0 6080.0 0.1 0.6384 0.7865 1021946 TimTec1_001181 OC(=O)C1CCCN1C(=O)OCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F16 compound treatment 114720.0 34200.0 0.56 86400.0 13200.0 0.21 0.5478 0.9096 3209882 TimTec1_001182 CCOc1ccc(cc1)N2C(=O)CCC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F17 compound treatment 107920.0 27400.0 0.45 59560.0 -13600.0 -0.22 0.1659 0.3308 3209883 TimTec1_001183 CCn1c2C(=O)CCCc2c3cc(Br)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F18 compound treatment 109280.0 28700.0 0.47 67840.0 -5360.0 -0.09 0.2751 0.5707 1674582 TimTec1_001184 OCCN(CC(=O)Nc1ccc(F)cc1)C(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F19 compound treatment 102000.0 21500.0 0.35 51480.0 -21700.0 -0.35 0.0057 0.0116 1384058 TimTec1_001185 Cc1ccc2oc3nc(N)c(cc3c(=O)c2c1)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F20 compound treatment 125440.0 44900.0 0.74 90320.0 17100.0 0.27 0.7171 0.9079 1143739 TimTec1_001186 CC(C)Cn1c(SCC(=O)Nc2ccc(F)cc2F)nc3ccccc3c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F21 compound treatment 108480.0 27900.0 0.46 75240.0 2040.0 0.03 0.3491 0.7552 1602491 TimTec1_001187 COC(=O)c1ccc(NC(=O)CSC(=S)N2CCOCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F22 compound treatment 120160.0 39600.0 0.65 77120.0 3920.0 0.06 0.5067 0.7712 3082498 TimTec1_001188 Brc1ccc(cc1)C(=O)CN2CCCC2=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F23 mock treatment 87280.0 6740.0 0.11 90160.0 17000.0 0.27 0.2698 0.923 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 F24 mock treatment 77480.0 -3060.0 -0.05 62520.0 -10700.0 -0.17 -0.1561 -0.8791 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G01 compound treatment 87040.0 6500.0 0.11 42560.0 -30600.0 -0.49 -0.2694 -0.5389 1278450 TimTec1_001189 CCOC(=O)c1cnn2c(N)c(C#N)cnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G02 compound treatment 24880.0 -55700.0 -0.92 11520.0 -61700.0 -0.98 -1.3448 -0.9994 1287956 TimTec1_001190 NC1=C(C#N)C(c2ccccc2Cl)c3c(S1)oc(cc3=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G03 compound treatment 75480.0 -5060.0 -0.08 51760.0 -21400.0 -0.34 -0.3007 -0.8548 1053983 TimTec1_001191 COC(=O)C1CNc2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G04 compound treatment 69200.0 -11300.0 -0.19 45080.0 -28100.0 -0.45 -0.4493 -0.925 3082499 TimTec1_001192 COC(=O)C1=C(N)OC(=C(C#N)C1c2ccncc2)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G05 compound treatment 123960.0 43400.0 0.72 99440.0 26200.0 0.42 0.8026 0.9671 3209884 TimTec1_001193 CC1=CC(C)(C)CC(=S)N1c2cccc(F)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G06 compound treatment 29680.0 -50900.0 -0.84 32720.0 -40500.0 -0.65 -1.0498 -0.9915 3082500 TimTec1_001194 NC1=C(C#N)C(=C(C#N)C(S1)c2cccs2)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G07 compound treatment 74280.0 -6260.0 -0.1 60280.0 -12900.0 -0.21 -0.2187 -0.9492 3209885 TimTec1_001195 O=C1CNC(=S)N1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G08 compound treatment 74120.0 -6420.0 -0.11 42640.0 -30600.0 -0.49 -0.4193 -0.8413 1277858 TimTec1_001196 Cc1c2cc(sc2nc3c(O)cc(=O)[nH]c13)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G09 compound treatment 120280.0 39700.0 0.66 68320.0 -4880.0 -0.08 0.4089 0.619 1296353 TimTec1_001197 CCOC(=O)c1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G10 compound treatment 44120.0 -36400.0 -0.6 37080.0 -36100.0 -0.58 -0.8322 -0.9998 3209886 TimTec1_001198 OC(=O)c1c(SC(C#N)c2ccc(Cl)cc2)nc(cc1c3ccccc3)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G11 compound treatment 30200.0 -50300.0 -0.83 27840.0 -45400.0 -0.72 -1.0988 -0.9976 1298662 TimTec1_001199 COC(=O)C1=C(C)NC(=C(C#N)C1c2ccc3OCCOc3c2)SCC(=O)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G12 compound treatment 123680.0 43100.0 0.71 74840.0 1640.0 0.03 0.5221 0.7326 1652210 TimTec1_001200 COC(=O)C1=C(N)OC(=C(C1c2ccc(OC)c(OC)c2)C(=O)OC)CC#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G13 compound treatment 82760.0 2220.0 0.04 48120.0 -25100.0 -0.4 -0.2567 -0.6396 1672888 TimTec1_001201 Oc1cc(=O)c2sc3nc(c4cccnc4)c5CCCCc5c3c2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G14 compound treatment 28200.0 -52300.0 -0.86 22040.0 -51200.0 -0.82 -1.1875 -0.9996 1564023 TimTec1_001202 CC(C)c1ccc(cc1)C2C3CN(C)CC=C3C(C#N)(C#N)C(=C2C#N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G15 compound treatment 88320.0 7780.0 0.13 53680.0 -19500.0 -0.31 -0.1292 -0.3838 3210009 TimTec1_001203 COC(=O)C1=CN2[C@@H](C#N)[C@H](c3cccnc3)C(C2C=C1)(C(=O)OC)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G16 compound treatment 17800.0 -62700.0 -1.04 12240.0 -61000.0 -0.97 -1.4193 -0.9995 1397215 TimTec1_001204 CCNC(=O)c1sc(C)nc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G17 compound treatment 46480.0 -34100.0 -0.56 29200.0 -44000.0 -0.7 -0.8934 -0.994 3082503 TimTec1_001205 CSc1nc(SCC(=O)C(C)C)nc(N)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G18 compound treatment 126560.0 46000.0 0.76 85480.0 12300.0 0.2 0.6756 0.8612 1115621 TimTec1_001206 CC(=O)Nc1nc2ccccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G19 compound treatment 36480.0 -44100.0 -0.73 27320.0 -45900.0 -0.73 -1.0313 -1.0 3210010 TimTec1_001207 NC1=C(C#N)C(c2ccc(Br)cc2)c3c(N1)c4ccccc4oc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G20 compound treatment 86840.0 6300.0 0.1 83480.0 10300.0 0.16 0.1894 0.9759 1129886 TimTec1_001208 CC1(C)C(C(=O)Nc2ccccc2C#N)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G21 compound treatment 113960.0 33400.0 0.55 83160.0 9960.0 0.16 0.5024 0.8751 1646804 TimTec1_001209 CC1=CC(=C(C#N)C(=S)C1CC(=O)c2cccs2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G22 compound treatment 75320.0 -5220.0 -0.09 43840.0 -29400.0 -0.47 -0.3918 -0.8235 1362352 TimTec1_001210 Cc1ccc(cc1)S(=O)(=O)N(CCO)c2cc3CCCCc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G23 mock treatment 94320.0 13800.0 0.23 75800.0 2600.0 0.04 0.1902 0.8225 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 G24 mock treatment 67440.0 -13100.0 -0.22 72760.0 -436.0 -0.01 -0.1578 -0.7295 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H01 compound treatment 9520.0 -71000.0 -1.17 3920.0 -69300.0 -1.1 -1.6097 -0.9996 1120313 TimTec1_001211 Cn1c2C(=O)CCCCc2c3cc(ccc13)C4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H02 compound treatment 20720.0 -59800.0 -0.99 19040.0 -54200.0 -0.86 -1.3086 -0.9978 3082508 TimTec1_001212 CC/1=NN(C(=O)\C1=C/c2c[nH]nc2c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H03 compound treatment 86440.0 5900.0 0.1 81960.0 8760.0 0.14 0.1676 0.9844 1013623 TimTec1_001213 NC(=O)c1nnn(Cc2ccccc2)c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H04 compound treatment 112000.0 31500.0 0.52 93880.0 20700.0 0.33 0.6003 0.976 3210011 TimTec1_001214 FC(F)(F)c1cc(oc(=S)c1C#N)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H05 compound treatment 7160.0 -73400.0 -1.21 8160.0 -65000.0 -1.04 -1.5895 -0.997 1733044 TimTec1_001215 NC(=O)c1ccc(nc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H06 compound treatment 93120.0 12600.0 0.21 91920.0 18700.0 0.3 0.3578 0.9843 1733896 TimTec1_001216 O=C(NCCC(c1ccccc1)c2ccccc2)c3cc4ccccc4c(=O)o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H07 compound treatment 99520.0 19000.0 0.31 110760.0 37600.0 0.6 0.6449 0.9544 1785401 TimTec1_001217 Clc1c(NCC2CCCO2)cn[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H08 compound treatment 68400.0 -12100.0 -0.2 82480.0 9280.0 0.15 -0.0371 -0.1489 3210012 TimTec1_001218 Cc1cc(C)c(C(=O)N2Cc3ccccc3N=C2S)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H09 compound treatment 127080.0 46500.0 0.77 111320.0 38100.0 0.61 0.9729 0.9933 1181388 TimTec1_001219 O=C(Nc1ccccc1)C(=C2CCCC2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H10 compound treatment 86760.0 6220.0 0.1 83720.0 10500.0 0.17 0.1912 0.9722 1174029 TimTec1_001220 C(N1CCN(Cc2ccccc2)C1c3ccco3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H11 compound treatment 104960.0 24400.0 0.4 97240.0 24000.0 0.38 0.556 0.9997 1687568 TimTec1_001221 O=C(Nc1ccccc1C(=O)Nc2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H12 compound treatment 99000.0 18500.0 0.3 85120.0 11900.0 0.19 0.3498 0.9742 1393827 TimTec1_001222 CCc1ccc(cc1)C(=O)CC2OC(=O)c3c2ccc(OC)c3OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H13 compound treatment 119720.0 39200.0 0.65 108200.0 35000.0 0.56 0.8518 0.9973 1145002 TimTec1_001223 CCC(=O)Nc1sc2CCCCCc2c1C(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H14 compound treatment 8480.0 -72100.0 -1.19 8840.0 -64400.0 -1.03 -1.5664 -0.9973 3210013 TimTec1_001224 Clc1ccc(SC2CC(=O)N(C2=O)c3ccc(Br)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H15 compound treatment 32080.0 -48500.0 -0.8 28280.0 -44900.0 -0.72 -1.0719 -0.9985 1022241 TimTec1_001225 O=C1CCN(N1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H16 compound treatment 123840.0 43300.0 0.71 106720.0 33500.0 0.53 0.8832 0.9897 3082550 TimTec1_001226 CC(C)(C)c1ccc(cc1)N2C(=O)CCC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H17 compound treatment 86040.0 5500.0 0.09 68000.0 -5200.0 -0.08 0.0056 0.0457 3210014 TimTec1_001227 N/N=C/1\CCCc2c1[nH]c3ccc(cc23)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H18 compound treatment 14960.0 -65600.0 -1.08 20160.0 -53000.0 -0.85 -1.3632 -0.9925 1154220 TimTec1_001228 Cc1n[nH]c2oc(=O)c(Cc3cccc(C)c3)c(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H19 compound treatment 97760.0 17200.0 0.28 77280.0 4080.0 0.07 0.247 0.8471 1503917 TimTec1_001229 Clc1ccc(cc1)C(=O)c2oc3ccccc3c2c4cnn(c4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H20 compound treatment 42320.0 -38200.0 -0.63 43640.0 -29600.0 -0.47 -0.7792 -0.9896 1445779 TimTec1_001230 Fc1ccc(CSc2nc3ccccc3c(=O)n2c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H21 compound treatment 80160.0 -381.0 -0.01 69440.0 -3760.0 -0.06 -0.0468 -0.7772 1530713 TimTec1_001231 O=C(NCCc1ccc(cc1)S(=O)(=O)N2CCCC2)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H22 compound treatment 60520.0 -20000.0 -0.33 104560.0 31400.0 0.5 0.1198 0.1999 3082554 TimTec1_001232 FC(F)(F)C1=Nc2ccccc2N(C1)c3ccc(Cl)c(Cl)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H23 mock treatment 111320.0 30800.0 0.51 87560.0 14400.0 0.23 0.5211 0.9352 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 H24 mock treatment 41360.0 -39200.0 -0.65 64720.0 -8480.0 -0.14 -0.5529 -0.8367 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I01 compound treatment 72200.0 -8340.0 -0.14 59000.0 -14200.0 -0.23 -0.2574 -0.9716 1641212 TimTec1_001233 Cc1cc(C)c(C#N)c(SCC(=O)N2CCCCC2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I02 compound treatment 4720.0 -75800.0 -1.25 4800.0 -68400.0 -1.09 -1.6559 -0.9976 1202800 TimTec1_001234 CC1=C(C#N)C(C(=C(N)O1)C(=O)OCc2ccccc2)c3cc(F)ccc3F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I03 compound treatment 19880.0 -60700.0 -1.0 16480.0 -56700.0 -0.9 -1.3473 -0.9987 1249954 TimTec1_001235 CC(C)c1ccc(C)cc1OCc2ccc(N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I04 compound treatment 88200.0 7660.0 0.13 72880.0 -316.0 -0.01 0.0858 0.6784 3210015 TimTec1_001236 COc1cc(OCCN2CCOCC2)ccc1C3C(=C(N)Oc4[nH]c(nc34)C(F)(F)F)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I05 compound treatment 83000.0 2460.0 0.04 72640.0 -556.0 -0.01 0.0224 0.5399 3082557 TimTec1_001237 CC(C)c1ccc(cc1)N2C(=CC(C)(C)NC2=S)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I06 compound treatment 41040.0 -39500.0 -0.65 39360.0 -33800.0 -0.54 -0.8424 -0.9956 1171191 TimTec1_001238 CCCc1n[nH]c2N(C(=C(C#N)C(c3c(C)onc3Cl)c12)N)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I07 compound treatment 99840.0 19300.0 0.32 82280.0 9080.0 0.14 0.3276 0.9363 1003607 TimTec1_001239 OC(=O)c1cc(nc2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I08 compound treatment 59920.0 -20600.0 -0.34 44360.0 -28800.0 -0.46 -0.5657 -0.9891 1696034 TimTec1_001240 CC(C)OC(=O)c1cc(N)c2c(c(sc2n1)c3cccs3)c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I09 compound treatment 104000.0 23500.0 0.39 85080.0 11900.0 0.19 0.4078 0.9459 3082561 TimTec1_001241 NC(=O)COc1ccc(cc1)C2C(=C(N)Oc3[nH]c(nc23)c4ccccc4)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I10 compound treatment 41200.0 -39300.0 -0.65 42840.0 -30400.0 -0.48 -0.8013 -0.9895 1275672 TimTec1_001242 CC(C)(C)c1cc(c2cccs2)c(C#N)c(SCC(=O)Oc3ccccc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I11 compound treatment 22240.0 -58300.0 -0.96 26200.0 -47000.0 -0.75 -1.2102 -0.9923 1564906 TimTec1_001243 COCc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccccc3COc4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I12 compound treatment 108400.0 27900.0 0.46 79320.0 6120.0 0.1 0.3942 0.8385 1280361 TimTec1_001244 CC(C)(C)c1nc2C(C(=C(N)Nc2o1)C(=O)N)c3ccc(OCC#N)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I13 compound treatment 82520.0 1980.0 0.03 64080.0 -9120.0 -0.15 -0.0796 -0.5348 1705544 TimTec1_001245 CC(C)c1ccc(cc1)C2C(=C(N)Oc3[nH]c(C)nc23)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I14 compound treatment 6600.0 -73900.0 -1.22 6560.0 -66600.0 -1.06 -1.6141 -0.9976 1235982 TimTec1_001246 CC1=C(OC(=C(C#N)C1c2ccc(F)cc2)N)C(=O)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I15 compound treatment 112480.0 31900.0 0.53 88200.0 15000.0 0.24 0.5419 0.936 1422848 TimTec1_001247 COC(=O)C1=C(C)Oc2oc(C)cc(=O)c2C1c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I16 compound treatment 55120.0 -25400.0 -0.42 56880.0 -16300.0 -0.26 -0.4806 -0.9735 1729172 TimTec1_001248 Nc1sc(NCC=C)c(C(=O)c2ccc(Br)s2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I17 compound treatment 65000.0 -15500.0 -0.26 73320.0 124.0 0.0 -0.18 -0.7016 1693885 TimTec1_001249 CCCc1nc2C(C(=C(N)Oc2o1)C#N)c3cccc(O)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I18 compound treatment 66240.0 -14300.0 -0.24 63160.0 -10000.0 -0.16 -0.28 -0.982 1371394 TimTec1_001250 Clc1ccccc1C(=O)NC(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I19 compound treatment 6760.0 -73800.0 -1.22 6520.0 -66700.0 -1.06 -1.6127 -0.9977 3210016 TimTec1_001251 CC1=C(C#N)C(C2=C(O1)C(=O)CCC2)c3ccccc3C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I20 compound treatment 93720.0 13200.0 0.22 84080.0 10900.0 0.17 0.2765 0.9937 3082567 TimTec1_001252 CC1(C)C(C(=O)Nc2nccs2)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I21 compound treatment 12960.0 -67600.0 -1.12 7880.0 -65300.0 -1.04 -1.525 -0.9994 3210017 TimTec1_001253 COCCC(=O)C1=CSC2=C(C1c3ccncc3)C(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I22 compound treatment 107520.0 27000.0 0.45 86720.0 13500.0 0.22 0.4673 0.9445 3082601 TimTec1_001254 O=c1n2CCCc2nc3scc(c4ccccc4)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I23 mock treatment 92080.0 11500.0 0.19 88120.0 14900.0 0.24 0.3029 0.9939 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 I24 mock treatment 63840.0 -16700.0 -0.28 65400.0 -7800.0 -0.12 -0.2828 -0.9352 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J01 compound treatment 75080.0 -5460.0 -0.09 132080.0 58900.0 0.94 0.5999 0.6363 1686618 TimTec1_001255 COC(=O)C1(CC2(CC3(CC(C1)(C(=O)OC)C2=O)C(=O)OC)C(=O)OC)C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J02 compound treatment 3720.0 -76800.0 -1.27 5080.0 -68100.0 -1.09 -1.6644 -0.997 3210018 TimTec1_001256 CCOc1cc(/C=C\2/SC(=N)N(C2=O)c3nccs3)ccc1OCCN4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J03 compound treatment 59880.0 -20700.0 -0.34 67400.0 -5800.0 -0.09 -0.3065 -0.8674 1190635 TimTec1_001257 CC1OC(NC(=O)c2ccccc2F)C(NC(=O)c3ccccc3F)OC1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J04 compound treatment 99360.0 18800.0 0.31 98520.0 25300.0 0.4 0.5051 0.9916 1013629 TimTec1_001258 OC(=O)c1cc(Cc2ccc(O)c(c2)C(=O)O)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J05 compound treatment 32080.0 -48500.0 -0.8 48320.0 -24900.0 -0.4 -0.846 -0.9476 3082606 TimTec1_001259 Clc1ccc(OCCCC(=O)Nc2ccc3OCCOc3c2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J06 compound treatment 22760.0 -57800.0 -0.95 40400.0 -32800.0 -0.52 -1.0441 -0.9599 3210135 TimTec1_001260 N/C(=N/C#N)/c1sc2nc3CCCCCc3cc2c1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J07 compound treatment 97520.0 17000.0 0.28 129160.0 56000.0 0.89 0.8289 0.8866 3082608 TimTec1_001261 CN(C)CCNc1cn[nH]c(=O)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J08 compound treatment 80800.0 259.0 0.0 82400.0 9200.0 0.15 0.1067 0.7274 3210136 TimTec1_001262 CS(=O)(=O)NCCOc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J09 compound treatment 97760.0 17200.0 0.28 107000.0 33800.0 0.54 0.582 0.9554 1582682 TimTec1_001263 OC(=O)c1ccccc1NC(=O)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J10 compound treatment 155240.0 74700.0 1.23 103920.0 30700.0 0.49 1.2182 0.9182 1203455 TimTec1_001264 Nc1ccc(cc1)C(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J11 compound treatment 105120.0 24600.0 0.41 99280.0 26100.0 0.42 0.5809 0.9999 1327302 TimTec1_001265 Cc1ccccc1NC(=O)c2ccccc2NC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J12 compound treatment 110200.0 29700.0 0.49 97120.0 23900.0 0.38 0.6158 0.9924 1350742 TimTec1_001266 OC(=O)c1cc(C(=O)O)c2cccc(Cl)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J13 compound treatment 28320.0 -52200.0 -0.86 35080.0 -38100.0 -0.61 -1.0391 -0.9853 1127240 TimTec1_001267 CNC(=O)c1c(N)sc2CCCCCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J14 compound treatment 5600.0 -74900.0 -1.24 6120.0 -67100.0 -1.07 -1.6307 -0.9974 3210137 TimTec1_001268 CC(C)(C)c1ccc(cc1)C(=O)CC(N2CCCCC2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J15 compound treatment 95800.0 15300.0 0.25 90000.0 16800.0 0.27 0.3675 0.9995 1913738 TimTec1_001269 Oc1ccc(/C=N/c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J16 compound treatment 72360.0 -8180.0 -0.14 82560.0 9360.0 0.15 0.01 0.0499 1404011 TimTec1_001270 O=C(Cc1ccccc1)Oc2ccc(cc2)C3SCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J17 compound treatment 5880.0 -74700.0 -1.23 6560.0 -66600.0 -1.06 -1.6225 -0.9973 1230646 TimTec1_001271 C1CCC(CC1)c2ccc3c(c2)c4CCCc5nccn3c45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J18 compound treatment 70480.0 -10100.0 -0.17 81440.0 8240.0 0.13 -0.0245 -0.1158 3210138 TimTec1_001272 Clc1ccc(CSC2CC(=O)N(C2=O)c3ccc(Br)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J19 compound treatment 97240.0 16700.0 0.28 96800.0 23600.0 0.38 0.4609 0.9883 1613380 TimTec1_001273 CN1C(=O)COc2ccc(cc12)C(=O)c3ccccc3C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J20 compound treatment 80520.0 -21.3 0.0 90320.0 17100.0 0.27 0.1927 0.7062 1384728 TimTec1_001274 COc1ccc(NCC(C#N)C(=O)NCc2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J21 compound treatment 64320.0 -16200.0 -0.27 69920.0 -3280.0 -0.05 -0.2263 -0.8294 3210139 TimTec1_001275 COc1ccc(CCNC(=N)Nc2nc(C)cc(C)n2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J22 compound treatment 11200.0 -69300.0 -1.14 19520.0 -53700.0 -0.86 -1.4143 -0.9897 3082616 TimTec1_001276 SC1=Nc2ccccc2CN1C(=O)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J23 mock treatment 98560.0 18000.0 0.3 87280.0 14100.0 0.22 0.369 0.9904 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 J24 mock treatment 56600.0 -23900.0 -0.4 73080.0 -116.0 0.0 -0.2808 -0.7104 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K01 compound treatment 42720.0 -37800.0 -0.62 65320.0 -7880.0 -0.13 -0.5302 -0.8326 3210140 TimTec1_001277 N=c1sc(C(=O)c2ccccc2)c3scc(c4ccccc4)n13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K02 compound treatment 31600.0 -48900.0 -0.81 31560.0 -41600.0 -0.66 -1.0405 -0.9952 1261528 TimTec1_001278 COc1cc(OC)cc(c1)C2C(=C(N)OC(=C2C#N)N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K03 compound treatment 83360.0 2820.0 0.05 63880.0 -9320.0 -0.15 -0.0721 -0.4633 1566998 TimTec1_001279 COc1ccc(NC(=O)Nc2ccc(OC)c(OC)c2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K04 compound treatment 52680.0 -27900.0 -0.46 67560.0 -5640.0 -0.09 -0.3887 -0.8295 1394262 TimTec1_001280 COC(=O)[C@H]1[C@H](c2ccccc2)[C@@](C#N)([C@@H]3C=CC(=C(C)N13)C(=O)OC)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K05 compound treatment 83560.0 3020.0 0.05 84560.0 11400.0 0.18 0.1633 0.8693 1004876 TimTec1_001281 OC(=O)c1cc(=O)cc(o1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K06 compound treatment 39200.0 -41300.0 -0.68 40040.0 -33200.0 -0.53 -0.8562 -0.992 3082619 TimTec1_001282 Cc1nc(/C=C(/N)\C#N)cn1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K07 compound treatment 80080.0 -461.0 -0.01 82840.0 9640.0 0.15 0.1033 0.6713 1429878 TimTec1_001283 COc1ccc2CCC(CC3(O)C(=O)Nc4ccccc43)C(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K08 compound treatment 67160.0 -13400.0 -0.22 68520.0 -4680.0 -0.07 -0.2089 -0.8961 1203304 TimTec1_001284 Cc1sc2nc(cc(N)c2c1C)C(=O)Oc3ccc(F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K09 compound treatment 111120.0 30600.0 0.5 120440.0 47200.0 0.75 0.8894 0.9811 3210142 TimTec1_001285 NC(=S)/C(=C\Nc1ccccc1C#N)/C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K10 compound treatment 84520.0 3980.0 0.07 82920.0 9720.0 0.15 0.156 0.927 1195774 TimTec1_001286 CC(C)c1ccc(cc1)C2C(=C(Oc3[nH]c(C)nc23)C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K11 compound treatment 105520.0 25000.0 0.41 78760.0 5560.0 0.09 0.3543 0.84 1673016 TimTec1_001287 COc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3ccc(OC(C)C)c(OC)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K12 compound treatment 86080.0 5540.0 0.09 67160.0 -6040.0 -0.1 -0.0034 -0.0255 1572307 TimTec1_001288 CCCN1CC=C2C(C#N)(C#N)C(=C(C#N)C(c3ccc(OCC(=O)N)cc3)C2(C)C1)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K13 compound treatment 88960.0 8420.0 0.14 93480.0 20300.0 0.32 0.3269 0.9289 1290293 TimTec1_001289 Cc1nc2c(OC(=C(C#N)C32CCC(CC3)c4ccccc4)N)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K14 compound treatment 19840.0 -60700.0 -1.0 22040.0 -51200.0 -0.82 -1.2851 -0.9948 1495492 TimTec1_001290 CC(C)N1CC=C2C(C1)C(C(=C(N)C2(C#N)C#N)C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K15 compound treatment 89680.0 9140.0 0.15 75440.0 2240.0 0.04 0.132 0.8511 1213258 TimTec1_001291 CCOC(=O)C(C#N)C(c1[nH]c(C)nc1O)c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K16 compound treatment 48040.0 -32500.0 -0.54 66240.0 -6960.0 -0.11 -0.4578 -0.8356 1320005 TimTec1_001292 CCCc1cc(ccc1OC(C)C)C2C(=C(N)Nc3oc(OC)nc23)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K17 compound treatment 61120.0 -19400.0 -0.32 61320.0 -11900.0 -0.19 -0.3605 -0.9684 1432035 TimTec1_001293 CC1(C)CC(=O)C2=C(C1)N(Cc3ccccc3)C(=C(C#N)C42CCOCC4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K18 compound treatment 30400.0 -50100.0 -0.83 30560.0 -42600.0 -0.68 -1.0658 -0.9952 1488829 TimTec1_001294 Clc1cccc(c1)C(=O)N(Cc2ccccc2)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K19 compound treatment 5400.0 -75100.0 -1.24 6880.0 -66300.0 -1.06 -1.6245 -0.9968 3210143 TimTec1_001295 Fc1ccc(cc1)C(=O)[C@@H]2[C@@H](C#N)[C@@](C#N)([C@@H]3N2C=Cc4ccccc34)C(=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K20 compound treatment 37960.0 -42600.0 -0.7 47480.0 -25700.0 -0.41 -0.7869 -0.967 1628961 TimTec1_001296 CC1(C)C(C(=O)Nc2ccc(cc2)S(=O)(=O)c3ccc(NC(=O)C4C(C)(C)C4(C)C)cc3)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K21 compound treatment 75280.0 -5260.0 -0.09 93240.0 20000.0 0.32 0.1645 0.4968 1142263 TimTec1_001297 COC(=O)C1=C(C)SC(=C(C#N)C1c2ccc(OC(C)C)c(OC)c2)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K22 compound treatment 49800.0 -30700.0 -0.51 50280.0 -22900.0 -0.37 -0.6171 -0.987 1427516 TimTec1_001298 O=C(N1CN(Cc2c3CCCCc3sc12)C4CCCCC4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K23 mock treatment 86800.0 6260.0 0.1 71720.0 -1480.0 -0.02 0.0564 0.5324 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 K24 mock treatment 47640.0 -32900.0 -0.54 76040.0 2840.0 0.05 -0.352 -0.6459 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L01 compound treatment 25120.0 -55400.0 -0.91 49960.0 -23200.0 -0.37 -0.9088 -0.9208 1725268 TimTec1_001299 CCc1cc2c(=O)c(coc2cc1OC(=O)C)c3ccn(n3)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L02 compound treatment 2880.0 -77700.0 -1.28 4320.0 -68900.0 -1.1 -1.6827 -0.997 3082669 TimTec1_001300 N=C1S/C(=C/c2ccco2)/C(=O)N1c3nccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L03 compound treatment 63320.0 -17200.0 -0.28 95680.0 22500.0 0.36 0.0524 0.1145 1704974 TimTec1_001301 COC1C(OC)N(CCN1S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L04 compound treatment 7560.0 -73000.0 -1.2 20200.0 -53000.0 -0.84 -1.4491 -0.9849 1126229 TimTec1_001302 CC(C)(C)c1cc(O)cc(c1CN2CCN(CCN)CC2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L05 compound treatment 104320.0 23800.0 0.39 116640.0 43400.0 0.69 0.7672 0.9639 3210144 TimTec1_001303 O=C1CN2C(=C1c3nc4ccccc4c(=O)[nH]3)NC(=O)c5ccccc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L06 compound treatment 84520.0 3980.0 0.07 104600.0 31400.0 0.5 0.4004 0.7931 1508923 TimTec1_001304 CN1CCC2(CC1)C(=C(N)Oc3n[nH]c(C(=O)OC(C)(C)C)c32)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L07 compound treatment 84680.0 4140.0 0.07 125360.0 52200.0 0.83 0.6362 0.7626 1206601 TimTec1_001305 O=c1[nH]nc(c2ccccc2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L08 compound treatment 70320.0 -10200.0 -0.17 106880.0 33700.0 0.54 0.2603 0.4626 3210145 TimTec1_001306 COC(=O)c1ccc2ccccc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L09 compound treatment 57000.0 -23500.0 -0.39 73200.0 3.75 0.0 -0.2747 -0.707 1306892 TimTec1_001307 OC(=O)c1c(NC(=O)c2ccc(Br)cc2)sc3CCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L10 compound treatment 95720.0 15200.0 0.25 110640.0 37400.0 0.6 0.5992 0.9257 1170047 TimTec1_001308 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCCC2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L11 compound treatment 77840.0 -2700.0 -0.04 96320.0 23100.0 0.37 0.2291 0.6171 1153508 TimTec1_001309 CCc1nc2ccccc2c(=O)n1c3ccc(OC)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L12 compound treatment 85080.0 4540.0 0.07 82320.0 9120.0 0.15 0.1558 0.9524 1500311 TimTec1_001310 OC(=O)c1cc(O)nc2c(Cl)cccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L13 compound treatment 18560.0 -62000.0 -1.02 15440.0 -57800.0 -0.92 -1.3744 -0.9986 1714700 TimTec1_001311 CCOc1ccc(NC(=O)C(=C2CCCCCC2)C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L14 compound treatment 30080.0 -50500.0 -0.83 8440.0 -64800.0 -1.03 -1.3188 -0.9943 3210146 TimTec1_001312 CN1CCN(CC1)C(CC(=O)c2ccc(C)cc2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L15 compound treatment 75840.0 -4700.0 -0.08 100800.0 27600.0 0.44 0.2562 0.5735 3082677 TimTec1_001313 C/C(=C/c1ccccc1)/C=N/c2c(C)n(C)n(c3ccccc3)c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L16 compound treatment 28240.0 -52300.0 -0.86 52400.0 -20800.0 -0.33 -0.8449 -0.9136 3210147 TimTec1_001314 Clc1ccccc1C(=O)Oc2ccc(cc2)C3SCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L17 compound treatment 87160.0 6620.0 0.11 96560.0 23400.0 0.37 0.3406 0.8776 3082679 TimTec1_001315 Clc1nsnc1N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L18 compound treatment 85480.0 4940.0 0.08 110880.0 37700.0 0.6 0.4824 0.7958 1080207 TimTec1_001316 CCn1c(=O)c2ccccc2[nH]c1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L19 compound treatment 12560.0 -68000.0 -1.12 19120.0 -54100.0 -0.86 -1.403 -0.9915 1587528 TimTec1_001317 Clc1nc2ccccc2n3c(nnc13)c4coc5ccccc5c4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L20 compound treatment 10320.0 -70200.0 -1.16 11960.0 -61200.0 -0.98 -1.5098 -0.9963 3082732 TimTec1_001318 OC(=O)C(CC(=O)c1ccc(Cl)cc1)Sc2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L21 compound treatment 44760.0 -35800.0 -0.59 48840.0 -24400.0 -0.39 -0.6922 -0.9793 3210266 TimTec1_001319 N#Cc1c(SC2CCCC2)nsc1SC3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L22 compound treatment 77560.0 -2980.0 -0.05 86920.0 13700.0 0.22 0.1199 0.5347 3210267 TimTec1_001320 Cc1n(C)c(c[n+]1c2c3CCCCCn3n(c4ccccc4)c2=O)c5ccc(C)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L23 mock treatment 80320.0 -221.0 0.0 81720.0 8520.0 0.14 0.0935 0.6878 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 L24 mock treatment 53280.0 -27300.0 -0.45 76080.0 2880.0 0.05 -0.2857 -0.6316 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M01 compound treatment 39240.0 -41300.0 -0.68 64120.0 -9080.0 -0.14 -0.5844 -0.8385 3082736 TimTec1_001321 Cc1ccc(cc1)S(=O)(=O)N2CCC(=C(O)c3ccccc23)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M02 compound treatment 3600.0 -76900.0 -1.27 5280.0 -67900.0 -1.08 -1.6635 -0.9968 3210268 TimTec1_001322 Cc1nc2C(C(=C(N)N(c2o1)c3ccccc3)C#N)c4c(C)n(nc4Cl)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M03 compound treatment 2840.0 -77700.0 -1.28 5160.0 -68000.0 -1.08 -1.6737 -0.9965 3082738 TimTec1_001323 Nc1cc(ccc1Oc2ccc(cc2)C3CCCCC3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M04 compound treatment 4080.0 -76500.0 -1.26 5960.0 -67200.0 -1.07 -1.6503 -0.9967 1129265 TimTec1_001324 OC(=O)c1c(SCc2ccc(C#N)cc2)nc(c3cccs3)c4CCCCc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M05 compound treatment 71600.0 -8940.0 -0.15 94200.0 21000.0 0.33 0.1324 0.3618 1016658 TimTec1_001325 C[N+](C)(C)CCOC(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M06 compound treatment 4880.0 -75700.0 -1.25 10520.0 -62700.0 -1.0 -1.5895 -0.9939 1533994 TimTec1_001326 NC1=C(C#N)C(c2c(noc2N1)c3cccc(O)c3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M07 compound treatment 9080.0 -71500.0 -1.18 12080.0 -61100.0 -0.97 -1.5229 -0.9955 1273967 TimTec1_001327 CCOc1ccc2nc(SCC(=O)c3cccs3)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M08 compound treatment 4320.0 -76200.0 -1.26 7280.0 -65900.0 -1.05 -1.6326 -0.996 1285313 TimTec1_001328 CC(C)(C)C1CCC2(CC1)C(C#N)C2(C#N)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M09 compound treatment 8080.0 -72500.0 -1.2 11120.0 -62100.0 -0.99 -1.5454 -0.9956 1588817 TimTec1_001329 CNc1sc(C(=O)CC=C)c(N)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M10 compound treatment 50960.0 -29600.0 -0.49 72480.0 -716.0 -0.01 -0.3534 -0.7234 1441689 TimTec1_001330 CCOC(=O)c1nc2C(C(=C(N)Nc2o1)C#N)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M11 compound treatment 75640.0 -4900.0 -0.08 106160.0 33000.0 0.53 0.3143 0.5912 1280958 TimTec1_001331 CCOc1ccc(cc1OC)C2C=C(N)Oc3[nH]c(COC)nc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M12 compound treatment 6800.0 -73700.0 -1.22 7480.0 -65700.0 -1.05 -1.6014 -0.9972 1479215 TimTec1_001332 CCc1ccc(cc1)N2C(=C(C#N)C(c3c(C)noc23)c4cccc(Cl)c4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M13 compound treatment 112000.0 31500.0 0.52 100040.0 26800.0 0.43 0.6697 0.9954 3082744 TimTec1_001333 N#C/C=C/N(C#N)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M14 compound treatment 25600.0 -54900.0 -0.91 34560.0 -38600.0 -0.62 -1.0767 -0.9822 1118063 TimTec1_001334 CCOC(=O)C1C(=C(OC(=C1C#N)N)c2ccc(Cl)cc2)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M15 compound treatment 57120.0 -23400.0 -0.39 102520.0 29300.0 0.47 0.0571 0.0941 3082746 TimTec1_001335 CCOC(=O)N1CCC2(CC1)C(=C(C)Nc3oc(C)nc32)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M16 compound treatment 73560.0 -6980.0 -0.12 97680.0 24500.0 0.39 0.1944 0.4779 3210269 TimTec1_001336 CCCc1nc2c(o1)N(C(=O)OCC)C(=C(C#N)C32CCNCC3)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M17 compound treatment 58080.0 -22500.0 -0.37 87400.0 14200.0 0.23 -0.1021 -0.235 1631479 TimTec1_001337 CC(C)N1C(=C(C#N)C2(CCNCC2)C(C#N)C1=O)S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M18 compound treatment 71640.0 -8900.0 -0.15 98840.0 25600.0 0.41 0.1851 0.4262 3210270 TimTec1_001338 CCN(CC)C(=O)c1cccc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M19 compound treatment 51080.0 -29500.0 -0.49 90240.0 17000.0 0.27 -0.1518 -0.2725 1388678 TimTec1_001339 COc1cc(ccc1OCCN2CCOCC2)C3C(=C(C)Nc4oc(C)nc34)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M20 compound treatment 61760.0 -18800.0 -0.31 95880.0 22700.0 0.36 0.0364 0.0765 3082750 TimTec1_001340 CCOC(=O)c1oc2ccc(/C=N\C(C)(C)C)c(Cl)c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M21 compound treatment 3760.0 -76800.0 -1.27 4720.0 -68500.0 -1.09 -1.668 -0.9972 3210271 TimTec1_001341 COC(=O)C1=C(OC(=C(C#N)C1c2ccccc2c3ccccc3)C)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M22 compound treatment 19040.0 -61500.0 -1.02 22400.0 -50800.0 -0.81 -1.2904 -0.9937 1636367 TimTec1_001342 CCCCN1COc2ccc(CCNC(=O)c3ccc(Cl)cc3)cc2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M23 mock treatment 80880.0 339.0 0.01 96400.0 23200.0 0.37 0.2655 0.7177 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 M24 mock treatment 69120.0 -11400.0 -0.19 97000.0 23800.0 0.38 0.135 0.3186 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N01 compound treatment 24920.0 -55600.0 -0.92 46040.0 -27200.0 -0.43 -0.9553 -0.9411 3210272 TimTec1_001343 CCc1cc2c(=O)c3c(cn4ccccc34)oc2cc1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N02 compound treatment 48520.0 -32000.0 -0.53 95760.0 22600.0 0.36 -0.1195 -0.1869 3082752 TimTec1_001344 Nc1nonc1N2C(=N)S/C(=C/c3ccccc3)/C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N03 compound treatment 21640.0 -58900.0 -0.97 30640.0 -42600.0 -0.68 -1.1671 -0.9845 1211420 TimTec1_001345 COc1ccc(cc1)C(=O)N2c3ccccc3CCc4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N04 compound treatment 60640.0 -19900.0 -0.33 122040.0 48800.0 0.78 0.3182 0.3766 1688649 TimTec1_001346 CC(=O)Nc1[nH]c2CCCCCc2c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N05 compound treatment 56680.0 -23900.0 -0.39 115240.0 42000.0 0.67 0.1953 0.2513 1368911 TimTec1_001347 Clc1c(NCc2ccco2)cnn(c3ccccc3)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N06 compound treatment 68040.0 -12500.0 -0.21 111640.0 38400.0 0.61 0.2874 0.4444 1227629 TimTec1_001348 COc1ccc(NC2CS(=O)(=O)CC2OC(=O)c3ccc(F)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N07 compound treatment 53800.0 -26700.0 -0.44 120080.0 46900.0 0.75 0.2163 0.2492 1520272 TimTec1_001349 O=C(Cc1ccccc1)Nc2c(cnn2c3ccccc3)C(=O)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N08 compound treatment 45760.0 -34800.0 -0.57 130200.0 57000.0 0.91 0.2365 0.22 1561090 TimTec1_001350 Cc1cc2nc(SCC(=O)NN)[nH]c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N09 compound treatment 51600.0 -28900.0 -0.48 96600.0 23400.0 0.37 -0.074 -0.1222 1634252 TimTec1_001351 O=C(Nc1ccccc1C(=O)N2CCN(Cc3ccccc3)CC2)c4ccccn4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N10 compound treatment 44960.0 -35600.0 -0.59 63360.0 -9840.0 -0.16 -0.5262 -0.8655 1534295 TimTec1_001352 COc1ccc(NC(=O)c2cccs2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N11 compound treatment 53440.0 -27100.0 -0.45 61320.0 -11900.0 -0.19 -0.4502 -0.9268 3082818 TimTec1_001353 FC(F)(F)c1nc2ccccc2c(=O)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N12 compound treatment 68120.0 -12400.0 -0.21 77600.0 4400.0 0.07 -0.0954 -0.44 3210273 TimTec1_001354 Cc1cc(OCc2ccc(Br)cc2)nc(n1)c3ccccc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N13 compound treatment 37600.0 -42900.0 -0.71 42200.0 -31000.0 -0.49 -0.8506 -0.9844 1039615 TimTec1_001355 O=c1n(c2ccccc2)c(nc3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N14 compound treatment 11520.0 -69000.0 -1.14 22080.0 -51100.0 -0.81 -1.3817 -0.9865 3210274 TimTec1_001356 FC(F)(F)c1cc(NC(=O)C(=S)NCc2ccco2)ccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N15 compound treatment 71480.0 -9060.0 -0.15 93800.0 20600.0 0.33 0.1264 0.3504 3210275 TimTec1_001357 CCOc1nnc(NS(=O)(=O)c2ccc(/N=C/c3ccccc3O)cc2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N16 compound treatment 60160.0 -20400.0 -0.34 116840.0 43600.0 0.7 0.254 0.3287 3082822 TimTec1_001358 Cc1sc(Cc2ccc(Cl)cc2)nc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N17 compound treatment 6000.0 -74500.0 -1.23 28080.0 -45100.0 -0.72 -1.3785 -0.9673 3082824 TimTec1_001359 N=C1SCC(=O)N1c2nccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N18 compound treatment 10400.0 -70100.0 -1.16 28120.0 -45100.0 -0.72 -1.3267 -0.9737 3210276 TimTec1_001360 CCn1c(SCC(=O)Nc2cccc(Cl)c2Cl)nc3ccccc3c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N19 compound treatment 3920.0 -76600.0 -1.26 5800.0 -67400.0 -1.07 -1.6539 -0.9967 1136080 TimTec1_001361 OC(c1oc2ccccc2c1c3cnn(c3)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N20 compound treatment 14800.0 -65700.0 -1.09 19840.0 -53400.0 -0.85 -1.3687 -0.9927 3210277 TimTec1_001362 FC(F)(F)c1cccc(c1)c2nc3ccccc3c(=O)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N21 compound treatment 12240.0 -68300.0 -1.13 15800.0 -57400.0 -0.91 -1.4441 -0.9946 3210278 TimTec1_001363 FC(F)(F)c1cc(NC(=O)C(=S)NCCNc2cccc3ccccc23)cc(c1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N22 compound treatment 43760.0 -36800.0 -0.61 47960.0 -25200.0 -0.4 -0.7137 -0.98 3082828 TimTec1_001364 COc1ccc(cc1)c2cs/c(=N\Cc3ccccc3)/[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N23 mock treatment 68840.0 -11700.0 -0.19 86960.0 13800.0 0.22 0.0185 0.0634 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 N24 mock treatment 78720.0 -1820.0 -0.03 86440.0 13200.0 0.21 0.128 0.6003 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O01 compound treatment 33160.0 -47400.0 -0.78 32840.0 -40400.0 -0.64 -1.0079 -0.9953 1081644 TimTec1_001365 COc1cc2CCN=C(CC#N)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O02 compound treatment 2560.0 -78000.0 -1.29 3760.0 -69400.0 -1.11 -1.6928 -0.9972 1714891 TimTec1_001366 COc1cc(OC)cc(c1)[C@@H]2[C@@H](C(C)(C)C)C(C#N)(C#N)[C@@H]3N2C=Cc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O03 compound treatment 30160.0 -50400.0 -0.83 29560.0 -43600.0 -0.7 -1.0799 -0.996 3082830 TimTec1_001367 CSc1nnc(c2ccccc2)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O04 compound treatment 33600.0 -46900.0 -0.77 34640.0 -38600.0 -0.61 -0.9825 -0.9934 3210280 TimTec1_001368 CC(C)(C)OC(=O)N1C(=C(C#N)C2(CCOCC2)c3nc([nH]c13)C(F)(F)F)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O05 compound treatment 57800.0 -22700.0 -0.38 92960.0 19800.0 0.32 -0.0427 -0.0871 1332895 TimTec1_001369 Cc1cc(=O)oc2cc(OC3OC(CO)C(O)C(O)C3O)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O06 compound treatment 24360.0 -56200.0 -0.93 34440.0 -38800.0 -0.62 -1.0926 -0.9805 1308936 TimTec1_001370 Fc1ccc(cc1)C(=O)CSC2=C(C#N)C(=O)C(C#N)C3(CCCC3)N2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O07 compound treatment 11960.0 -68600.0 -1.13 38440.0 -34800.0 -0.55 -1.1922 -0.9459 3210391 TimTec1_001371 O=C(NCCOc1ccccc1c2ccccc2)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O08 compound treatment 40600.0 -39900.0 -0.66 71440.0 -1760.0 -0.03 -0.486 -0.7365 1195667 TimTec1_001372 Cc1ccc(cc1)C(=O)[C@@H]2[C@@H](C(C)(C)C)C(C#N)(C#N)[C@@]3(C)C=Cc4ccccc4N23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O09 compound treatment 24480.0 -56100.0 -0.93 30440.0 -42800.0 -0.68 -1.1362 -0.9887 1300208 TimTec1_001373 Nc1sc(Nc2ccccc2)c(C#N)c1C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O10 compound treatment 3920.0 -76600.0 -1.26 6480.0 -66700.0 -1.06 -1.6463 -0.9963 3210392 TimTec1_001374 COC(=O)c1ccc(cc1)[C@@H]2[C@H]3CC(CC=C3C(C#N)(C#N)C(=C2C#N)N)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O11 compound treatment 59800.0 -20700.0 -0.34 57720.0 -15500.0 -0.25 -0.4165 -0.9871 1596487 TimTec1_001375 CCCc1nc2C(C(=C(N)Oc2[nH]1)C#N)c3cccc(O)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O12 compound treatment 67000.0 -13500.0 -0.22 63000.0 -10200.0 -0.16 -0.273 -0.9877 3082899 TimTec1_001376 COc1ccc(cc1)[C@H]2NC(=C(C#N)C(=O)[C@@H]2[n+]3ccccc3)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O13 compound treatment 77680.0 -2860.0 -0.05 70080.0 -3120.0 -0.05 -0.0685 -0.9997 3210393 TimTec1_001377 NC1=C(C#N)C(c2nc(oc2N1c3ccccc3)c4ccccc4)c5cccc(O)c5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O14 compound treatment 7400.0 -73100.0 -1.21 28360.0 -44800.0 -0.71 -1.359 -0.9687 1397691 TimTec1_001378 CC1=C(C(C(=C(N)S1)C#N)c2ccoc2)C(=O)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O15 compound treatment 39480.0 -41100.0 -0.68 54720.0 -18500.0 -0.29 -0.6875 -0.9303 1415097 TimTec1_001379 CCCc1nc2C(C(=C(N)Nc2o1)C#N)c3ccc(OC(C)C)c(OC)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O16 compound treatment 64040.0 -16500.0 -0.27 92400.0 19200.0 0.31 0.0238 0.0581 3210394 TimTec1_001380 Clc1cccc(c1)C(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O17 compound treatment 3040.0 -77500.0 -1.28 5840.0 -67400.0 -1.07 -1.6637 -0.9962 3082903 TimTec1_001381 Cc1nc2C(C(=C(N)Nc2o1)C#N)c3c[nH]nc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O18 compound treatment 14120.0 -66400.0 -1.1 16400.0 -56800.0 -0.91 -1.4154 -0.9955 1268817 TimTec1_001382 COc1ccccc1NC(=O)c2ccc(cc2)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O19 compound treatment 3000.0 -77500.0 -1.28 4800.0 -68400.0 -1.09 -1.6759 -0.9968 3210395 TimTec1_001383 COc1cccc(c1)[C@@H]2[C@H]3CC(C)CC=C3C(C#N)(C#N)C(=C2C#N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O20 compound treatment 71960.0 -8580.0 -0.14 95240.0 22000.0 0.35 0.1483 0.3914 1627987 TimTec1_001384 CCOC(=O)c1c(NC(=O)C)sc2C(=O)NCCCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O21 compound treatment 35960.0 -44600.0 -0.74 26400.0 -46800.0 -0.75 -1.0478 -1.0 1713250 TimTec1_001385 CC(C)NC(=O)CSc1cc(c2cccnc2)c3CCCCc3c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O22 compound treatment 40240.0 -40300.0 -0.67 43920.0 -29300.0 -0.47 -0.8004 -0.9849 3210396 TimTec1_001386 CCOC(=O)c1c(N)sc2C(=O)C(CCc12)Sc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O23 mock treatment 63960.0 -16600.0 -0.27 86040.0 12800.0 0.2 -0.0488 -0.1427 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 O24 mock treatment 64600.0 -15900.0 -0.26 91400.0 18200.0 0.29 0.0191 0.0487 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P01 compound treatment 32440.0 -48100.0 -0.79 21440.0 -51800.0 -0.82 -1.1448 -0.9998 3082907 TimTec1_001387 COc1ccc2c(=S)c(c3cc4ccccc4o3)c(C)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P02 compound treatment 41920.0 -38600.0 -0.64 42680.0 -30500.0 -0.49 -0.7947 -0.9911 1033890 TimTec1_001388 C(Cc1nc2ccccc2[nH]1)Cc3nc4ccccc4[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P03 compound treatment 40240.0 -40300.0 -0.67 59320.0 -13900.0 -0.22 -0.6268 -0.8941 3082909 TimTec1_001389 S=CC1=C2NCCCN2C3CCCCC31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P04 compound treatment 32920.0 -47600.0 -0.79 56120.0 -17100.0 -0.27 -0.7483 -0.8995 1117255 TimTec1_001390 NC(=N)c1cccc(NC(=O)Nc2cccc(c2)C(=N)N)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P05 compound treatment 49600.0 -30900.0 -0.51 100160.0 27000.0 0.43 -0.0573 -0.0858 1246425 TimTec1_001391 Cc1c(NC2CS(=O)(=O)CC2O)c(=O)n(c3ccccc3)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P06 compound treatment 60120.0 -20400.0 -0.34 108120.0 34900.0 0.56 0.1552 0.2385 1671747 TimTec1_001392 O=c1c(C2=NCCCCC2)c3[nH]c(cn3n1c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P07 compound treatment 50360.0 -30200.0 -0.5 116800.0 43600.0 0.69 0.1391 0.1627 1595982 TimTec1_001393 CCCN(CCC)C(=O)c1c(NC(=O)c2ccco2)sc3CC(C)CCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P08 compound treatment 45120.0 -35400.0 -0.58 92520.0 19300.0 0.31 -0.1957 -0.2961 1216494 TimTec1_001394 NNC(=O)c1ccc2c(=O)[nH][nH]c(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P09 compound treatment 40000.0 -40500.0 -0.67 85920.0 12700.0 0.2 -0.3298 -0.4716 1492209 TimTec1_001395 O=c1[nH]c(nc2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P10 compound treatment 44240.0 -36300.0 -0.6 101640.0 28400.0 0.45 -0.1032 -0.1373 1735994 TimTec1_001396 CCn1c(N)c(sc1=S)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P11 compound treatment 29760.0 -50800.0 -0.84 26640.0 -46600.0 -0.74 -1.1174 -0.9982 1341596 TimTec1_001397 CCc1nc2ccccc2c(=O)n1c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P12 compound treatment 10400.0 -70100.0 -1.16 13760.0 -59400.0 -0.95 -1.4886 -0.995 1919107 TimTec1_001398 Cc1cc(NCCCN2CCOCC2)nc(n1)c3ccccc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P13 compound treatment 52720.0 -27800.0 -0.46 60680.0 -12500.0 -0.2 -0.4658 -0.9303 1420208 TimTec1_001399 CCOC(=O)c1c(NC(=O)C2C(C)(C)C2(C)C)sc3CCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P14 compound treatment 71280.0 -9260.0 -0.15 94680.0 21500.0 0.34 0.134 0.3574 1140583 TimTec1_001400 COc1ccc(C)cc1NC(=O)C(=S)NCc2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P15 compound treatment 67560.0 -13000.0 -0.21 85000.0 11800.0 0.19 -0.0185 -0.0648 3210397 TimTec1_001401 NC(=N)NS(=O)(=O)c1ccc(/N=C/c2ccccc2O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P16 compound treatment 41520.0 -39000.0 -0.64 71320.0 -1880.0 -0.03 -0.4766 -0.7391 1142293 TimTec1_001402 O=C(Oc1ccc(cc1)C2SCCS2)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P17 compound treatment 59600.0 -20900.0 -0.35 86880.0 13700.0 0.22 -0.0902 -0.2207 1739320 TimTec1_001403 Clc1ccccc1C(=O)Nc2nonc2NC=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P18 compound treatment 45360.0 -35200.0 -0.58 70720.0 -2480.0 -0.04 -0.4386 -0.7534 1453837 TimTec1_001404 O=C(Cc1ccccc1)c2ccccc2C(=O)NCc3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P19 compound treatment 45360.0 -35200.0 -0.58 75600.0 2400.0 0.04 -0.3836 -0.659 1670037 TimTec1_001405 CCc1cccc(CC)c1NC(=O)COc2ccccc2C(=O)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P20 compound treatment 47320.0 -33200.0 -0.55 70200.0 -3000.0 -0.05 -0.4215 -0.7658 3210398 TimTec1_001406 CC(C)Cc1ccc(/C=C/C(=O)N2CCN(C\C=C\c3ccccc3)CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P21 compound treatment 45960.0 -34600.0 -0.57 59680.0 -13500.0 -0.22 -0.556 -0.9112 3082991 TimTec1_001407 Cc1nc(SCc2noc(CSc3nc(C)c(C)c(C)c3C#N)n2)c(C#N)c(C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P22 compound treatment 57720.0 -22800.0 -0.38 44960.0 -28200.0 -0.45 -0.5846 -0.9961 3210399 TimTec1_001408 Cc1ccc2NC(=O)/C(=N\N3C(=O)c4ccccc4C3=O)/c2c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P23 mock treatment 70120.0 -10400.0 -0.17 61040.0 -12200.0 -0.19 -0.2586 -0.9982 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2066 P24 mock treatment 57200.0 -23300.0 -0.39 34480.0 -38700.0 -0.62 -0.7088 -0.9743 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A01 compound treatment 12320.0 -65800.0 -1.09 14960.0 -73900.0 -1.18 -1.6008 -0.9992 1609023 TimTec1_001409 COc1ccc(CC(=O)n2[nH]c(=O)ccc2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A02 compound treatment 6280.0 -71800.0 -1.19 6440.0 -82500.0 -1.31 -1.7673 -0.9987 3210400 TimTec1_001410 CCN1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A03 compound treatment 103040.0 25000.0 0.41 83320.0 -5570.0 -0.09 0.2286 0.5422 3210401 TimTec1_001411 OCC1OC(C(O)C1O)N2C3CCNC(=O)C3N=C2N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A04 compound treatment 147800.0 69700.0 1.15 152960.0 64100.0 1.02 1.5359 0.9982 1501937 TimTec1_001412 O=C(Nc1cccc(c1)N2CCCC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A05 compound treatment 108280.0 30200.0 0.5 151720.0 62800.0 1.0 1.0606 0.9482 1302244 TimTec1_001413 CS(=O)(=O)N(Cc1ccccc1)c2ccccc2C(=O)NC3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A06 compound treatment 148760.0 70700.0 1.17 167680.0 78800.0 1.26 1.713 0.9993 3082998 TimTec1_001414 Nc1nc(SCc2ccccc2)n(n1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A07 compound treatment 150200.0 72100.0 1.19 146480.0 57600.0 0.92 1.4909 0.9917 1224047 TimTec1_001415 COc1ccccc1c2nn(CNc3ccccc3)c(=S)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A08 compound treatment 137360.0 59300.0 0.98 103520.0 14600.0 0.23 0.8568 0.8517 3083000 TimTec1_001416 CCOC(=O)c1sc(SC)nc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A09 compound treatment 137440.0 59400.0 0.98 149320.0 60400.0 0.96 1.3739 1.0 1232083 TimTec1_001417 Brc1ccc2C(=O)N(C(c3ccccc3)c4ccccc4)C(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A10 compound treatment 135040.0 57000.0 0.94 149160.0 60300.0 0.96 1.3441 0.9999 1258394 TimTec1_001418 CCN(CC)C(=O)c1c[nH]c2ccccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A11 compound treatment 26840.0 -51200.0 -0.85 40120.0 -48800.0 -0.78 -1.1477 -0.9991 1352649 TimTec1_001419 C(N1CCCN(Cc2ccccc2)C1c3ccncc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A12 compound treatment 25920.0 -52200.0 -0.86 30800.0 -58100.0 -0.93 -1.2635 -0.9993 1285436 TimTec1_001420 Brc1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A13 compound treatment 162960.0 84900.0 1.4 153840.0 64900.0 1.04 1.7228 0.9889 3210402 TimTec1_001421 COc1cc(cc(OC)c1OC)C/2=NOC(=O)\C2=C/c3ccc(Cl)cc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A14 compound treatment 162160.0 84100.0 1.39 161320.0 72400.0 1.15 1.7977 0.9958 3083004 TimTec1_001422 CC1(C)CC(=O)C2=C(C1)OC3=C(C2c4cccnc4)C(=O)CC(C)(C)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A15 compound treatment 134360.0 56300.0 0.93 162640.0 73700.0 1.18 1.4881 0.9932 3210403 TimTec1_001423 CSc1sc(C)cc1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A16 compound treatment 150640.0 72600.0 1.2 158360.0 69500.0 1.11 1.6299 0.9992 1473282 TimTec1_001424 N=c1[nH]c(cs1)c2ccc3OCCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A17 compound treatment 122640.0 44600.0 0.74 112800.0 23900.0 0.38 0.7896 0.9531 1291516 TimTec1_001425 Nc1nonc1NC(=O)CSc2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A18 compound treatment 193000.0 115000.0 1.9 188120.0 99200.0 1.58 2.4597 0.9959 1069221 TimTec1_001426 CSc1nnnn1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A19 compound treatment 40800.0 -37300.0 -0.62 45400.0 -43500.0 -0.69 -0.9253 -0.9982 1502089 TimTec1_001427 COc1ccc(cc1)C2C3CCC=C3C(=C(N)C2(C#N)C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A20 compound treatment 142440.0 64400.0 1.06 147560.0 58700.0 0.94 1.4125 0.998 1057528 TimTec1_001428 CC(=O)Oc1cccc2ccc(O)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A21 compound treatment 117920.0 39800.0 0.66 124200.0 35300.0 0.56 0.863 0.997 3210521 TimTec1_001429 Cc1c(C)c(/C=N/O)c(C)c(C)c1/C=N/O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A22 compound treatment 114880.0 36800.0 0.61 120120.0 31200.0 0.5 0.7815 0.9951 1551108 TimTec1_001430 CCOC(=O)C1CCN(CC1)C(=O)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A23 mock treatment 84200.0 6120.0 0.1 82560.0 -6330.0 -0.1 1.0E-4 7.0E-4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 A24 mock treatment 77000.0 -1080.0 -0.02 53560.0 -35300.0 -0.56 -0.4108 -0.7291 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B01 compound treatment 71240.0 -6840.0 -0.11 80760.0 -8130.0 -0.13 -0.1715 -0.9976 1318272 TimTec1_001431 COc1ccc2nc(sc2c1)C(=O)N3CCN(C)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B02 compound treatment 5520.0 -72600.0 -1.2 5600.0 -83300.0 -1.33 -1.7856 -0.9987 1256461 TimTec1_001432 OC(=O)c1ccc(Nc2nnc(c3ccccc3)c(n2)c4ccccc4)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B03 compound treatment 73720.0 -4360.0 -0.07 86080.0 -2810.0 -0.04 -0.0826 -0.9742 3083011 TimTec1_001433 FC(F)(F)c1cccc(c1)c2ccc(/C=C(\C#N)/c3ccccc3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B04 compound treatment 139640.0 61600.0 1.02 160680.0 71800.0 1.14 1.5276 0.9983 3210522 TimTec1_001434 C(C1COC(=N1)C2=N[C@@H](Cc3ccccc3)CO2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B05 compound treatment 145720.0 67600.0 1.12 177480.0 88600.0 1.41 1.788 0.9932 3083012 TimTec1_001435 Cc1nnc(/N=C/2\S/C(=C/c3ccc(cc3)C(=O)O)/C(=O)N2CC=C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B06 compound treatment 144280.0 66200.0 1.09 158320.0 69400.0 1.11 1.5552 1.0 3210523 TimTec1_001436 C/C(=N\O)/c1ccc2OCCOCCOCCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B07 compound treatment 85640.0 7560.0 0.12 94440.0 5550.0 0.09 0.1508 0.9857 1208416 TimTec1_001437 O=C1N(CSc2nc3ccccc3s2)c4cccc5cccc1c45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B08 compound treatment 8760.0 -69300.0 -1.14 9240.0 -79700.0 -1.27 -1.7068 -0.9987 3210524 TimTec1_001438 C[C@@H]1[C@@H]2CCC3[C@@](C)(CC(=O)O)CCC[C@]3(C)C2Cc4occc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B09 compound treatment 142200.0 64100.0 1.06 162720.0 73800.0 1.18 1.5805 0.9986 1668666 TimTec1_001439 C(SCc1ccccc1)c2cn3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B10 compound treatment 8720.0 -69400.0 -1.14 11880.0 -77000.0 -1.23 -1.6775 -0.9994 3210525 TimTec1_001440 ONC(=O)c1cccc2/C(=N\O)/c3ccccc3-c21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B11 compound treatment 172280.0 94200.0 1.56 207320.0 118000.0 1.89 2.4343 0.9954 3083091 TimTec1_001441 CCCOc1ccc(/C=C/C(=O)Nc2nnc[nH]2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B12 compound treatment 9080.0 -69000.0 -1.14 11040.0 -77900.0 -1.24 -1.6828 -0.9991 1621908 TimTec1_001442 NS(=O)(=O)c1nn2cc(nc2s1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B13 compound treatment 108280.0 30200.0 0.5 107480.0 18600.0 0.3 0.562 0.9691 1239473 TimTec1_001443 Clc1c(NCc2ccccc2)cn[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B14 compound treatment 138280.0 60200.0 0.99 149520.0 60600.0 0.97 1.386 0.9999 3210526 TimTec1_001444 OC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)/C=C/c3ccccn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B15 compound treatment 153960.0 75900.0 1.25 212280.0 123000.0 1.97 2.2763 0.9763 3210527 TimTec1_001445 Brc1cc(c2coc3ccccc3c2=O)c4OCOCc4c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B16 compound treatment 11000.0 -67100.0 -1.11 13120.0 -75800.0 -1.21 -1.6369 -0.9991 3083094 TimTec1_001446 COc1cc(SC#N)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B17 compound treatment 128520.0 50400.0 0.83 160880.0 72000.0 1.15 1.4001 0.9876 1121522 TimTec1_001447 COc1ccc(CCCc2nc3ccccc3[nH]2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B18 compound treatment 193880.0 116000.0 1.91 198280.0 109000.0 1.74 2.5845 0.9989 3210528 TimTec1_001448 CNC(=S)Nc1ccc(OC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B19 compound treatment 61520.0 -16600.0 -0.27 69080.0 -19800.0 -0.32 -0.4166 -0.9974 1022826 TimTec1_001449 O=C(Nc1ccccc1)Oc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B20 compound treatment 200800.0 123000.0 2.03 224440.0 136000.0 2.16 2.9601 0.9995 3083097 TimTec1_001450 CC1CCCCN1C(=O)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B21 compound treatment 102680.0 24600.0 0.41 144400.0 55500.0 0.88 0.9128 0.9376 3210529 TimTec1_001451 O=C(NCc1ccco1)c2ccccc2N(Cc3ccccc3)S(=O)(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B22 compound treatment 96160.0 18100.0 0.3 122600.0 33700.0 0.54 0.591 0.9615 1271782 TimTec1_001452 CC(=O)Oc1ccc2c(NC3(OC(=O)C)C(=O)c4ccccc4C23OC(=O)C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B23 mock treatment 142200.0 64100.0 1.06 169200.0 80300.0 1.28 1.6535 0.9955 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 B24 mock treatment 82600.0 4520.0 0.07 101040.0 12100.0 0.19 0.1897 0.9142 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C01 compound treatment 63880.0 -14200.0 -0.23 112400.0 23500.0 0.37 0.0992 0.2245 1645231 TimTec1_001453 CCn1cnc2c(=O)[nH][nH]c(=O)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C02 compound treatment 27160.0 -50900.0 -0.84 30640.0 -58300.0 -0.93 -1.2508 -0.9988 2086755 TimTec1_001454 CCOC(=O)N1C/C(=C\c2ccccc2)/C(=O)\C(=C\c3ccccc3)\C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C03 compound treatment 119680.0 41600.0 0.69 107880.0 19000.0 0.3 0.6996 0.9322 1308938 TimTec1_001455 CCc1cc2c(=O)c(coc2cc1OC(C)C(=O)O)c3csc(C)n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C04 compound treatment 136000.0 57900.0 0.96 132480.0 43600.0 0.69 1.1673 0.9877 1446072 TimTec1_001456 CC1CCCN(C1)C(=O)c2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C05 compound treatment 27320.0 -50800.0 -0.84 34400.0 -54500.0 -0.87 -1.2066 -0.9998 1636408 TimTec1_001457 Cc1ccc(NC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)OCc4ccccc4)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C06 compound treatment 8560.0 -69500.0 -1.15 9480.0 -79400.0 -1.27 -1.7064 -0.9988 3083101 TimTec1_001458 Nc1n/c(=N\c2ccccc2)/ss1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C07 compound treatment 115280.0 37200.0 0.61 124520.0 35600.0 0.57 0.8358 0.9992 1676195 TimTec1_001459 CCSc1nc2ccccc2n1CC(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C08 compound treatment 44120.0 -34000.0 -0.56 50920.0 -38000.0 -0.61 -0.8243 -0.9993 3083103 TimTec1_001460 CSc1nc(N)c(s1)C(=O)Nc2ccc(cc2)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C09 compound treatment 101280.0 23200.0 0.38 106920.0 18000.0 0.29 0.474 0.99 3210530 TimTec1_001461 Cc1nc2ccc(/N=C/c3ccccc3O)cc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C10 compound treatment 10640.0 -67400.0 -1.11 13480.0 -75400.0 -1.2 -1.6371 -0.9993 1342383 TimTec1_001462 O=C(N(Cc1ccccc1)Cc2ccccc2)c3c[nH]c4ccccc4c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C11 compound treatment 131000.0 52900.0 0.87 153080.0 64200.0 1.02 1.3411 0.9969 1668351 TimTec1_001463 OC(=O)C1CCCN1C(=O)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C12 compound treatment 108280.0 30200.0 0.5 168320.0 79400.0 1.27 1.2477 0.917 1266673 TimTec1_001464 O=C(Nc1ncccn1)c2c[nH]c3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C13 compound treatment 133120.0 55000.0 0.91 192640.0 104000.0 1.65 1.8117 0.9602 3083106 TimTec1_001465 Fc1ccccc1C/2=NOC(=O)\C2=C/Nc3ccc(Cl)cn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C14 compound treatment 135200.0 57100.0 0.94 159560.0 70700.0 1.13 1.4632 0.9961 1516165 TimTec1_001466 CCOC(=O)C1=C(C)OC(=C(C1c2cccnc2)C(=O)OCC)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C15 compound treatment 153640.0 75600.0 1.25 156600.0 67700.0 1.08 1.6451 0.9974 3083108 TimTec1_001467 CSc1sc(C)cc1/C=N/O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C16 compound treatment 88400.0 10300.0 0.17 92880.0 3990.0 0.06 0.1654 0.9096 3210531 TimTec1_001468 Clc1ccc(NC(=O)/N=c/2\[nH]c(cs2)c3ccccc3)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C17 compound treatment 61680.0 -16400.0 -0.27 86880.0 -2010.0 -0.03 -0.2141 -0.7855 3083183 TimTec1_001469 Nc1nonc1NC(=O)CSC(=N)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C18 compound treatment 10080.0 -68000.0 -1.12 10640.0 -78300.0 -1.25 -1.6756 -0.9986 1579055 TimTec1_001470 COc1ccc(cc1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C19 compound treatment 10960.0 -67100.0 -1.11 13560.0 -75300.0 -1.2 -1.6324 -0.9992 1328959 TimTec1_001471 CCOc1ccc(OCC)c(c1)C2C(Cc3ccccc3)N4C(C=Cc5ccccc45)C2(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C20 compound treatment 150720.0 72600.0 1.2 164720.0 75800.0 1.21 1.7025 1.0 3083185 TimTec1_001472 COC(=O)Nc1nccs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C21 compound treatment 123400.0 45300.0 0.75 155280.0 66400.0 1.06 1.2772 0.9856 1288354 TimTec1_001473 Cc1ccc(c(C)c1)c2c(C#N)c(N)n(C)c(=O)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C22 compound treatment 36120.0 -42000.0 -0.69 34920.0 -54000.0 -0.86 -1.098 -0.9942 1283442 TimTec1_001474 O=C(Nc1ccc2OCOc2c1)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C23 mock treatment 125480.0 47400.0 0.78 142920.0 54000.0 0.86 1.1622 0.9989 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 C24 mock treatment 94720.0 16600.0 0.27 119240.0 30300.0 0.48 0.5363 0.9641 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D01 compound treatment 10560.0 -67500.0 -1.11 12160.0 -76700.0 -1.22 -1.6529 -0.9989 3083186 TimTec1_001475 O=C1CC(Sc2ccc3ccccc3c2)C4COC1O4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D02 compound treatment 126640.0 48600.0 0.8 126880.0 38000.0 0.61 0.995 0.9904 1501922 TimTec1_001476 OC(=O)c1nn(Cc2ccccc2)nc1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D03 compound treatment 66760.0 -11300.0 -0.19 69160.0 -19700.0 -0.31 -0.3545 -0.969 3210532 TimTec1_001477 S/C(=C(/C(=O)c1ccccc1)\[n+]2ccccc2)/NC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D04 compound treatment 131280.0 53200.0 0.88 150680.0 61800.0 0.98 1.3174 0.9984 3083190 TimTec1_001478 O=C(N[C@@H]1COC(=O)C1)OCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D05 compound treatment 116520.0 38400.0 0.63 128920.0 40000.0 0.64 0.8998 1.0 3210533 TimTec1_001479 O=C(C(=C1Nc2ccccc2N1)C#N)c3cc[n+](Cc4ccccc4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D06 compound treatment 128000.0 49900.0 0.82 136160.0 47300.0 0.75 1.1154 0.999 3083192 TimTec1_001480 OC(=O)c1ccc(/C=C/C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D07 compound treatment 61560.0 -16500.0 -0.27 82800.0 -6090.0 -0.1 -0.2615 -0.9034 1703831 TimTec1_001481 Brc1ccc(NC(=O)C2(CCN3CC2)c4ccccc4C3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D08 compound treatment 83720.0 5640.0 0.09 91760.0 2870.0 0.05 0.0982 0.9462 1474907 TimTec1_001482 OC1CC(c2ccccc2Cl)C3(C(C1)c4ccccc4Cl)C(=O)NC(=O)NC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D09 compound treatment 98200.0 20100.0 0.33 114560.0 25700.0 0.41 0.5242 0.9947 3210647 TimTec1_001483 Cc1cccn2c(=O)c(/C=N/c3ccc(Cl)cc3)c(Sc4ccccc4)nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D10 compound treatment 15560.0 -62500.0 -1.03 19920.0 -69000.0 -1.1 -1.5071 -0.9995 3083196 TimTec1_001484 Cc1ccc(cc1)S(=O)(=O)c2ccc(/C=C/c3ccco3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D11 compound treatment 137440.0 59400.0 0.98 153400.0 64500.0 1.03 1.4199 0.9997 1185515 TimTec1_001485 O=C(NCCc1nc2ccccc2[nH]1)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D12 compound treatment 140880.0 62800.0 1.04 148280.0 59400.0 0.95 1.4024 0.999 3083198 TimTec1_001486 COc1ccc(/C=C/2\N=C(N(C2=O)c3nc4ccc(cc4s3)C(=O)O)c5ccccc5)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D13 compound treatment 139680.0 61600.0 1.02 140120.0 51200.0 0.82 1.2964 0.9941 1329192 TimTec1_001487 Cc1cc(=O)n2c3C(=O)N(Cc4ccccc4)C(=O)c3sc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D14 compound treatment 147720.0 69600.0 1.15 143080.0 54200.0 0.86 1.4236 0.9901 3210648 TimTec1_001488 CC(=O)Nc1ccc(cc1C(=O)O)S(=O)(=O)NN2C(=O)/C(=C/c3ccco3)/N=C2c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D15 compound treatment 131240.0 53200.0 0.88 142560.0 53700.0 0.86 1.2254 0.9999 3083200 TimTec1_001489 Cc1nnc(C)n1/N=C/c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D16 compound treatment 143120.0 65000.0 1.07 153280.0 64400.0 1.03 1.4849 0.9997 1026134 TimTec1_001490 O=C(c1cc2ccccc2o1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D17 compound treatment 132200.0 54100.0 0.89 146680.0 57800.0 0.92 1.283 0.9999 1337169 TimTec1_001491 CCCC(=O)c1ccc(cc1)C(C)CCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D18 compound treatment 143440.0 65400.0 1.08 164480.0 75600.0 1.2 1.6148 0.9985 1082112 TimTec1_001492 COc1cccc(NC(=S)Nc2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D19 compound treatment 152880.0 74800.0 1.23 168440.0 79500.0 1.27 1.7696 0.9999 1198422 TimTec1_001493 NC(=O)CCNC(=O)C(c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D20 compound treatment 133560.0 55500.0 0.92 137560.0 48700.0 0.78 1.1961 0.9966 1112637 TimTec1_001494 CCC(C)NC(=O)c1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D21 compound treatment 50240.0 -27800.0 -0.46 64120.0 -24800.0 -0.39 -0.6041 -0.9971 3210649 TimTec1_001495 Fc1ccc(cc1)c2cs/c(=N\c3ccccc3)/n2Cc4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D22 compound treatment 98000.0 19900.0 0.33 130080.0 41200.0 0.66 0.6967 0.9489 1228411 TimTec1_001496 OC1(C2C(=O)NC(=O)NC2=O)C(=O)c3ccccc3C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D23 mock treatment 117880.0 39800.0 0.66 114400.0 25500.0 0.41 0.7521 0.9734 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 D24 mock treatment 76360.0 -1720.0 -0.03 92440.0 3550.0 0.06 0.0199 0.3153 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E01 compound treatment 77520.0 -556.0 -0.01 87120.0 -1770.0 -0.03 -0.0265 -0.891 1636299 TimTec1_001497 COc1ccc2C=CC3C=CC(O)C4Oc1c2C43CCN(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E02 compound treatment 20600.0 -57500.0 -0.95 25640.0 -63300.0 -1.01 -1.3838 -0.9995 3083205 TimTec1_001498 CC(C)(C)C1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E03 compound treatment 78120.0 43.8 0.0 97040.0 8150.0 0.13 0.0923 0.711 3210650 TimTec1_001499 Cn1c(=O)c(C2=NNC3=NNC(C23)c4ccccc4)c(O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E04 compound treatment 109760.0 31700.0 0.52 114760.0 25900.0 0.41 0.6613 0.9931 3083208 TimTec1_001500 O=C(N1CCCCC1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E05 compound treatment 112600.0 34500.0 0.57 124560.0 35700.0 0.57 0.8049 1.0 1501857 TimTec1_001501 COc1ccc(NC(=O)CC2CS(=O)(=O)CC2CC(=O)Nc3ccc(OC)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E06 compound treatment 56200.0 -21900.0 -0.36 61080.0 -27800.0 -0.44 -0.5688 -0.9948 1493097 TimTec1_001502 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2cnnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E07 compound treatment 38680.0 -39400.0 -0.65 44320.0 -44600.0 -0.71 -0.9622 -0.999 3210651 TimTec1_001503 Oc1ccc(/C=N/c2ccc(cc2)N3CCOCC3)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E08 compound treatment 124840.0 46800.0 0.77 112000.0 23100.0 0.37 0.8063 0.9427 1097150 TimTec1_001504 COc1ccc(NC(=O)c2sc(SC)nc2N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E09 compound treatment 9400.0 -68700.0 -1.13 10680.0 -78200.0 -1.25 -1.6831 -0.9989 3210652 TimTec1_001505 O=C/1Nc2ccccc2\C1=N/N3C(=O)C4C=CC=CC4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E10 compound treatment 50600.0 -27500.0 -0.45 59600.0 -29300.0 -0.47 -0.6509 -0.9999 1413901 TimTec1_001506 O=C(N(c1ccccc1)c2ccccc2)c3c[nH]c4ccccc4c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E11 compound treatment 60800.0 -17300.0 -0.29 60680.0 -28200.0 -0.45 -0.5196 -0.9758 3210653 TimTec1_001507 CC(C)(C)C(=O)CSc1ncnc2[nH]cnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E12 compound treatment 122960.0 44900.0 0.74 129280.0 40400.0 0.64 0.9791 0.9975 1279481 TimTec1_001508 CCOC(=O)CC(N)c1ccccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E13 compound treatment 9840.0 -68200.0 -1.13 9960.0 -78900.0 -1.26 -1.6861 -0.9985 3210654 TimTec1_001509 CCc1sc2sncc2c1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E14 compound treatment 30120.0 -48000.0 -0.79 32320.0 -56600.0 -0.9 -1.1974 -0.9979 1490642 TimTec1_001510 Cc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3C(=O)CC(C)(C)CC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E15 compound treatment 119880.0 41800.0 0.69 138840.0 49900.0 0.8 1.0509 0.9975 3082121 TimTec1_001511 CCSc1cc(CC)sc1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E16 compound treatment 118280.0 40200.0 0.66 129160.0 40300.0 0.64 0.9231 0.9999 3082123 TimTec1_001512 CN(C(=O)CSC(=S)N1CCCC1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E17 compound treatment 124040.0 46000.0 0.76 135520.0 46600.0 0.74 1.062 0.9999 3210655 TimTec1_001513 CCOC(=O)/C=C(/C)\Nc1nonc1NC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E18 compound treatment 117080.0 39000.0 0.64 136720.0 47800.0 0.76 0.9943 0.9965 3082125 TimTec1_001514 Nc1nnc(o1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E19 compound treatment 68040.0 -10000.0 -0.17 77360.0 -11500.0 -0.18 -0.2471 -0.9987 1386928 TimTec1_001515 Cc1ccc(C2C(Cc3ccccc3)N4C=Cc5ccccc5C4C2(C#N)C(=O)N)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E20 compound treatment 108720.0 30600.0 0.51 119320.0 30400.0 0.48 0.7006 0.9998 3082127 TimTec1_001516 CCOC(=O)Cc1ccccc1C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E21 compound treatment 7320.0 -70800.0 -1.17 9760.0 -79100.0 -1.26 -1.7177 -0.9993 3210656 TimTec1_001517 O=C/1/C(=C/C2CCCO2)/CC\C1=C/C3CCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E22 compound treatment 63120.0 -15000.0 -0.25 78160.0 -10700.0 -0.17 -0.2955 -0.9839 1433367 TimTec1_001518 CC(C)C(=O)Nc1ccc(cc1)c2nc3cc(C)ccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E23 mock treatment 94360.0 16300.0 0.27 121920.0 33000.0 0.53 0.5623 0.9513 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 E24 mock treatment 73320.0 -4760.0 -0.08 87240.0 -1650.0 -0.03 -0.0742 -0.8954 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F01 compound treatment 94200.0 16100.0 0.27 103240.0 14300.0 0.23 0.3499 0.9971 1232600 TimTec1_001519 COCC(=O)OCC1CCCN2CCCCC12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F02 compound treatment 106280.0 28200.0 0.47 120360.0 31500.0 0.5 0.6838 0.9993 3082129 TimTec1_001520 CC(=O)OCc1cnn(n1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F03 compound treatment 45600.0 -32500.0 -0.54 46080.0 -42800.0 -0.68 -0.8616 -0.9929 3210657 TimTec1_001521 O=C(CCCN1C(=O)S/C(=C/c2ccccc2)/C1=S)NC3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F04 compound treatment 135480.0 57400.0 0.95 137520.0 48600.0 0.78 1.2181 0.995 1023719 TimTec1_001522 Clc1ncnc2n(cnc12)C3CCCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F05 compound treatment 113400.0 35300.0 0.58 107000.0 18100.0 0.29 0.6164 0.9474 3210658 TimTec1_001523 CCc1nnc(/N=C/2\S/C(=C/c3ccc(cc3)C(=O)O)/C(=O)N2CC=C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F06 compound treatment 168600.0 90500.0 1.49 137480.0 48600.0 0.77 1.6042 0.9532 3082133 TimTec1_001524 Brc1ccc(/C=C/C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F07 compound treatment 94920.0 16800.0 0.28 111960.0 23100.0 0.37 0.4566 0.9905 3082134 TimTec1_001525 Nc1nnc(CCN2C(=O)S/C(=C/c3ccccc3)/C2=O)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F08 compound treatment 110800.0 32700.0 0.54 126280.0 37400.0 0.6 0.8033 0.9988 1022021 TimTec1_001526 CC1(C)OC2C(CO)OC(C2O1)n3cnc4c(O)ncnc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F09 compound treatment 88840.0 10800.0 0.18 88000.0 -894.0 -0.01 0.1156 0.6483 3210659 TimTec1_001527 OC(=O)COc1ccccc1/C=N/N2CCN(Cc3ccc(Cl)cc3)CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F10 compound treatment 75440.0 -2640.0 -0.04 73400.0 -15500.0 -0.25 -0.2054 -0.8191 3210660 TimTec1_001528 CN(C)c1ccc(cc1)C2=NN(C(C2)NC(Cc3c[nH]c4ccccc34)C(=O)O)C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F11 compound treatment 131120.0 53000.0 0.88 132440.0 43500.0 0.69 1.1099 0.9934 1300950 TimTec1_001529 O=C(CN1C(=O)c2ccccc2C1=O)Nc3nnc[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F12 compound treatment 132920.0 54800.0 0.91 140680.0 51800.0 0.83 1.2238 0.9989 1127108 TimTec1_001530 CCC(Sc1nc2cccc(CC)c2c(=O)n1c3ccc(OC)cc3)C(=O)NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F13 compound treatment 56840.0 -21200.0 -0.35 55200.0 -33700.0 -0.54 -0.6276 -0.9786 3082764 TimTec1_001531 Clc1nc(C#N)c(C#N)nc1C(=C2Nc3ccccc3N2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F14 compound treatment 81840.0 3760.0 0.06 91840.0 2950.0 0.05 0.0771 0.9905 3210661 TimTec1_001532 CC(C)C(C(=O)NN1C(=O)/C(=C/c2ccccn2)/N=C1c3ccccc3)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F15 compound treatment 10640.0 -67400.0 -1.11 10440.0 -78500.0 -1.25 -1.6713 -0.9983 3082765 TimTec1_001533 C/C=C(/C)\C(=O)OC1CC(O)(C(C)C)C2C(CC(=CCC12C)C)OC(=O)c3ccc(O)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F16 compound treatment 112200.0 34100.0 0.56 139040.0 50100.0 0.8 0.9635 0.9853 1203282 TimTec1_001534 CC(O)CNC(=O)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F17 compound treatment 125920.0 47800.0 0.79 130720.0 41800.0 0.67 1.0298 0.9964 1114140 TimTec1_001535 COc1ccc(CCCC(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F18 compound treatment 121800.0 43700.0 0.72 134120.0 45200.0 0.72 1.0201 1.0 1082103 TimTec1_001536 Fc1ccc(NC(=S)Nc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F19 compound treatment 124520.0 46400.0 0.77 132880.0 44000.0 0.7 1.0378 0.999 1119735 TimTec1_001537 COc1ccc2[nH]cc(CCNC(=O)c3ccco3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F20 compound treatment 129000.0 50900.0 0.84 133360.0 44500.0 0.71 1.0955 0.9964 3210662 TimTec1_001538 CCOC(=O)C1=C(Nc2ccccc2)OCC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F21 compound treatment 80440.0 2360.0 0.04 101560.0 12700.0 0.2 0.1703 0.8284 3082768 TimTec1_001539 CC(C)NCC(O)COc1ccc(/C=C/c2cc(C)no2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F22 compound treatment 15000.0 -63100.0 -1.04 28080.0 -60800.0 -0.97 -1.4216 -0.9994 3210663 TimTec1_001540 O=C1C(/C(=N/c2ccccc2)/c3ccccc13)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F23 mock treatment 85040.0 6960.0 0.11 103040.0 14100.0 0.23 0.2407 0.9511 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 F24 mock treatment 84160.0 6080.0 0.1 113240.0 24300.0 0.39 0.3454 0.8617 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G01 compound treatment 55000.0 -23100.0 -0.38 63160.0 -25700.0 -0.41 -0.5594 -0.9993 3210787 TimTec1_001541 CC1=C(NC(=S)NC(=O)c2ccccc2)NCc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G02 compound treatment 51840.0 -26200.0 -0.43 60640.0 -28300.0 -0.45 -0.6247 -0.9998 3082771 TimTec1_001542 N#C/C(=C\c1ccccc1/C=C(\C#N)/c2ccc3OCOc3c2)/c4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G03 compound treatment 74400.0 -3680.0 -0.06 80360.0 -8530.0 -0.14 -0.1391 -0.9339 3210788 TimTec1_001543 OC(=O)CC1N=Cc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G04 compound treatment 68640.0 -9440.0 -0.16 82120.0 -6770.0 -0.11 -0.1865 -0.984 3210789 TimTec1_001544 C1Oc2ccc(/C=C/C=N/c3ccc(cc3)N4CCOCC4)cc2O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G05 compound treatment 112120.0 34000.0 0.56 134320.0 45400.0 0.72 0.9093 0.9922 1707466 TimTec1_001545 CN1CCN(CC(O)COc2ccccc2OCc3nc(C)no3)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G06 compound treatment 145880.0 67800.0 1.12 128000.0 39100.0 0.62 1.2322 0.9618 3210790 TimTec1_001546 CC1=C(Oc2ccccc2N1)C(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G07 compound treatment 73600.0 -4480.0 -0.07 83480.0 -5410.0 -0.09 -0.1133 -0.997 1121781 TimTec1_001547 Cc1ccc(C)n1c2ccc(cc2)C(=O)OCC(=O)c3c(C)c(C)cc(C)c3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G08 compound treatment 90200.0 12100.0 0.2 105360.0 16500.0 0.26 0.3271 0.991 1240166 TimTec1_001548 Nc1[nH]c(=S)sc1C(=O)Nc2nccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G09 compound treatment 108600.0 30500.0 0.5 109960.0 21100.0 0.34 0.5937 0.9805 3082775 TimTec1_001549 Brc1ccc(cc1)C2OCC(=S)N2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G10 compound treatment 93840.0 15800.0 0.26 101240.0 12300.0 0.2 0.3231 0.9905 1301555 TimTec1_001550 CC(C)N(CCC#N)C(=O)c1c[nH]c2ccccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G11 compound treatment 111000.0 32900.0 0.54 134720.0 45800.0 0.73 0.9008 0.9894 1162047 TimTec1_001551 OC(=O)c1ccccc1C(=O)Nc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G12 compound treatment 9800.0 -68300.0 -1.13 9840.0 -79100.0 -1.26 -1.6879 -0.9985 1376806 TimTec1_001552 Cc1ccc(C)c(c1)C2C3CCCC=C3C(=C(N)C2(C#N)C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G13 compound treatment 100800.0 22700.0 0.38 109120.0 20200.0 0.32 0.4932 0.9972 1912519 TimTec1_001553 CN(C)Cc1cc(/C=N/C2CCCCC2)c(S)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G14 compound treatment 25040.0 -53000.0 -0.88 22120.0 -66800.0 -1.06 -1.3716 -0.9953 1339047 TimTec1_001554 CCc1ccc(s1)C(C2C(=O)CC(C)(C)CC2=O)C3C(=O)CC(C)(C)CC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G15 compound treatment 127520.0 49400.0 0.82 129000.0 40100.0 0.64 1.0291 0.9927 3082839 TimTec1_001555 CCc1cc2cc(sc2s1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G16 compound treatment 107280.0 29200.0 0.48 128360.0 39500.0 0.63 0.7857 0.9914 3210791 TimTec1_001556 Nc1nonc1OCCNc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G17 compound treatment 110800.0 32700.0 0.54 113320.0 24400.0 0.39 0.6573 0.9871 1225048 TimTec1_001557 CC(=O)Nc1nonc1NC2=CC(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G18 compound treatment 111160.0 33100.0 0.55 125480.0 36600.0 0.58 0.7985 0.9995 1004952 TimTec1_001558 OC(c1nc2ccccc2[nH]1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G19 compound treatment 124440.0 46400.0 0.77 123480.0 34600.0 0.55 0.931 0.987 1382010 TimTec1_001559 CCOc1ccc(OCC)c(CC2OC(=NC2=O)c3ccccc3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G20 compound treatment 31760.0 -46300.0 -0.76 38520.0 -50400.0 -0.8 -1.1083 -0.9997 3082843 TimTec1_001560 COc1ccc(/C=C(/C#N)\c2ccc(Cl)cc2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G21 compound treatment 32480.0 -45600.0 -0.75 55880.0 -33000.0 -0.53 -0.9043 -0.9847 1449158 TimTec1_001561 Brc1cccc(c1)C(CC(=O)c2ccccc2)C(C#N)C(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G22 compound treatment 56480.0 -21600.0 -0.36 89880.0 986.0 0.02 -0.241 -0.6753 1173213 TimTec1_001562 Clc1ccc(Cl)c(OCC(=O)NCc2ccccc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G23 mock treatment 96880.0 18800.0 0.31 94120.0 5230.0 0.08 0.2784 0.8662 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 G24 mock treatment 66040.0 -12000.0 -0.2 86480.0 -2410.0 -0.04 -0.1677 -0.8286 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H01 compound treatment 87440.0 9360.0 0.15 83800.0 -5090.0 -0.08 0.0519 0.2972 3210792 TimTec1_001563 CN12CCCCC2C(COc3ccccc3Br)CCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H02 compound treatment 23160.0 -54900.0 -0.91 23640.0 -65300.0 -1.04 -1.3764 -0.9977 3082846 TimTec1_001564 Cc1ccc(cc1)C2=NNC3(CCOC(C)(C)C3)S2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H03 compound treatment 102120.0 24000.0 0.4 98440.0 9550.0 0.15 0.3882 0.9134 3210793 TimTec1_001565 Clc1ccccc1/C=N/C2CCS(=O)(=O)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H04 compound treatment 111840.0 33800.0 0.56 106200.0 17300.0 0.28 0.5891 0.9474 1272351 TimTec1_001566 CC(C)(C)c1ccc2OCCOCCOCCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H05 compound treatment 99600.0 21500.0 0.36 111880.0 23000.0 0.37 0.5103 0.9999 3210794 TimTec1_001567 c1nn(c2ccccc2)c3ncn4nnnc4c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H06 compound treatment 120040.0 42000.0 0.69 128760.0 39900.0 0.64 0.9391 0.9991 3082850 TimTec1_001568 COc1cccc(/C=C/C(=O)O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H07 compound treatment 66720.0 -11400.0 -0.19 77400.0 -11500.0 -0.18 -0.2621 -0.9999 3210795 TimTec1_001569 COc1ccc(cc1OC)C2=N/C(=C/c3c(C)nn(c3N4CCCCC4)c5ccccc5)/C(=O)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H08 compound treatment 111480.0 33400.0 0.55 122840.0 33900.0 0.54 0.7725 1.0 3210796 TimTec1_001570 Cn1c(=O)c(C/2=NNC(=O)\C2=C/c3c[nH]c4ccccc34)c(O)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H09 compound treatment 52520.0 -25600.0 -0.42 45560.0 -43300.0 -0.69 -0.7867 -0.972 1574162 TimTec1_001571 CCc1cc(c2n[nH]c(C)c2c3nc4ccccc4n3C)c(O)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H10 compound treatment 127560.0 49500.0 0.82 139160.0 50300.0 0.8 1.1441 1.0 1654421 TimTec1_001572 CS(=O)(=O)N(Cc1ccc(cc1)C(=O)O)c2cccc(Cl)c2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H11 compound treatment 132320.0 54200.0 0.9 157720.0 68800.0 1.1 1.4088 0.9949 1562719 TimTec1_001573 O=C(CCN1C(=O)c2ccccc2C1=O)Nc3nnc[nH]3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H12 compound treatment 54080.0 -24000.0 -0.4 55120.0 -33800.0 -0.54 -0.6607 -0.9886 3210797 TimTec1_001574 Clc1ccc(cc1)N(C(=O)Nc2ccccc2Br)C3=NCCS3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H13 compound treatment 126320.0 48200.0 0.8 151240.0 62300.0 0.99 1.2658 0.994 1779116 TimTec1_001575 CCOC(=O)CCc1n[nH]c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H14 compound treatment 116720.0 38600.0 0.64 123080.0 34200.0 0.54 0.8364 0.9969 3210798 TimTec1_001576 CC(=O)OC1C(OC2C(OC(=O)C)C(=O)OC12)n3ccc(=O)[nH]c3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H15 compound treatment 43760.0 -34300.0 -0.57 65640.0 -23300.0 -0.37 -0.6626 -0.9789 3082856 TimTec1_001577 CC(C)C1C(O)C/C(=C/CC/C(=C/C1O)/C)/C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H16 compound treatment 131120.0 53000.0 0.88 115960.0 27100.0 0.43 0.9242 0.9468 1079739 TimTec1_001578 CS(=O)(=O)c1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H17 compound treatment 103800.0 25700.0 0.42 116840.0 27900.0 0.45 0.6152 0.9997 1036359 TimTec1_001579 Cc1ccc(CCCC(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H18 compound treatment 106600.0 28500.0 0.47 115960.0 27100.0 0.43 0.638 0.999 1014539 TimTec1_001580 S=C(Nc1ccccc1)N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H19 compound treatment 81360.0 3280.0 0.05 100960.0 12100.0 0.19 0.1743 0.8724 1593359 TimTec1_001581 Cc1ccc(cc1)c2nc3sc4C(=O)CC(C)(C)Cc4n3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H20 compound treatment 92200.0 14100.0 0.23 106120.0 17200.0 0.27 0.359 0.9967 1240459 TimTec1_001582 CCOC(=O)C1C(=O)CN(C1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H21 compound treatment 70120.0 -7960.0 -0.13 85280.0 -3610.0 -0.06 -0.1336 -0.9316 3082920 TimTec1_001583 CC12CCCCC2N(CCC(=O)N)c3ccccc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H22 compound treatment 75920.0 -2160.0 -0.04 86240.0 -2650.0 -0.04 -0.0551 -0.9963 1468638 TimTec1_001584 O=C1c2ccccc2C(=O)C1(Nc3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H23 mock treatment 89040.0 11000.0 0.18 105640.0 16700.0 0.27 0.3167 0.9821 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 H24 mock treatment 55360.0 -22700.0 -0.37 66000.0 -22900.0 -0.36 -0.5232 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I01 compound treatment 42040.0 -36000.0 -0.59 66120.0 -22800.0 -0.36 -0.6773 -0.9719 1500758 TimTec1_001585 CCC(=O)NC1CC2C(OC1=O)c3cccc(C)c3NC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I02 compound treatment 48680.0 -29400.0 -0.49 52000.0 -36900.0 -0.59 -0.7589 -0.9954 3082924 TimTec1_001586 CC1CCC/C(=C\c2ccc3OCOc3c2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I03 compound treatment 69520.0 -8560.0 -0.14 75680.0 -13200.0 -0.21 -0.2488 -0.9811 3210799 TimTec1_001587 COC(=O)C1(C)NC2(CCCCC2)Cc3ccccc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I04 compound treatment 18480.0 -59600.0 -0.98 21080.0 -67800.0 -1.08 -1.4599 -0.9989 1512799 TimTec1_001588 CC(C)(C)C1CCc2c(C1)sc3NC(NC(=O)c23)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I05 compound treatment 107520.0 29400.0 0.49 101040.0 12100.0 0.19 0.4806 0.9186 1550718 TimTec1_001589 Cc1noc(COc2ccccc2OCC(=O)N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I06 compound treatment 86200.0 8120.0 0.13 94480.0 5590.0 0.09 0.1578 0.9802 3082927 TimTec1_001590 Cc1[nH]c(=O)n(c(=O)c1C)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I07 compound treatment 77840.0 -236.0 0.0 96560.0 7670.0 0.12 0.0836 0.6842 1716137 TimTec1_001591 CS(=O)(=O)Nc1cc(NS(=O)(=O)C)cc(c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I08 compound treatment 71680.0 -6400.0 -0.11 72040.0 -16900.0 -0.27 -0.2646 -0.9168 1611777 TimTec1_001592 COc1ccc(NC(=O)c2sc(=S)[nH]c2N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I09 compound treatment 50760.0 -27300.0 -0.45 56880.0 -32000.0 -0.51 -0.6796 -0.9981 3210800 TimTec1_001593 Cc1ccc(cc1)C(=O)/N=c\2/cccc[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I10 compound treatment 84680.0 6600.0 0.11 110640.0 21700.0 0.35 0.3222 0.8867 1119826 TimTec1_001594 O=C(N1CCCCC1)c2c[nH]c3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I11 compound treatment 108280.0 30200.0 0.5 126480.0 37600.0 0.6 0.7762 0.9958 1603574 TimTec1_001595 Cc1sc(N)c(C(=O)N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I12 compound treatment 84960.0 6880.0 0.11 94640.0 5750.0 0.09 0.1451 0.9943 1363974 TimTec1_001596 COC(=O)C1(C#N)C(C(N2C1C=Cc3ccccc23)C(=O)c4ccccc4)c5ccc(C)cc5C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I13 compound treatment 114680.0 36600.0 0.6 124000.0 35100.0 0.56 0.8229 0.9993 1916807 TimTec1_001597 CCS(=O)(=O)c1ccsc1S(=O)(=O)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I14 compound treatment 10600.0 -67500.0 -1.11 15320.0 -73600.0 -1.17 -1.6168 -0.9997 3082931 TimTec1_001598 NC1=C(C#N)C2=CCCCC2C(c3cccs3)C1(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I15 compound treatment 77560.0 -516.0 -0.01 88560.0 -334.0 -0.01 -0.0098 -0.9743 1914041 TimTec1_001599 CSc1sc(SC)c(CO)c1CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I16 compound treatment 86360.0 8280.0 0.14 105800.0 16900.0 0.27 0.2872 0.9505 3082933 TimTec1_001600 CC(C)(Oc1ccccc1Cl)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I17 compound treatment 99080.0 21000.0 0.35 121920.0 33000.0 0.53 0.6174 0.9795 1737803 TimTec1_001601 CC(=O)Nc1nonc1Nc2cc(C)nn2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I18 compound treatment 93480.0 15400.0 0.25 106920.0 18000.0 0.29 0.383 0.9981 3082935 TimTec1_001602 COc1ccccc1C(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I19 compound treatment 103480.0 25400.0 0.42 116080.0 27200.0 0.43 0.6029 0.9999 1115158 TimTec1_001603 Cc1cc(C)c(C)c(C(=O)O)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I20 compound treatment 97520.0 19400.0 0.32 97280.0 8390.0 0.13 0.3215 0.9246 3210920 TimTec1_001604 CCNC(=S)Nc1ccc(OC)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I21 compound treatment 90920.0 12800.0 0.21 90000.0 1110.0 0.02 0.1624 0.7633 3082938 TimTec1_001605 Clc1ccc(/C(=C\c2ccc3OCOc3c2)/C#N)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I22 compound treatment 80720.0 2640.0 0.04 113520.0 24600.0 0.39 0.3084 0.7809 1045982 TimTec1_001606 NC(=O)NS(=O)(=O)c1ccc(N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I23 mock treatment 92400.0 14300.0 0.24 92240.0 3350.0 0.05 0.2049 0.8454 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 I24 mock treatment 48040.0 -30000.0 -0.5 64240.0 -24700.0 -0.39 -0.6284 -0.9934 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J01 compound treatment 3760.0 -74300.0 -1.23 5960.0 -82900.0 -1.32 -1.8021 -0.9993 1479505 TimTec1_001607 OCCOc1c(Cl)cc(Cl)c2cccnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J02 compound treatment 46120.0 -32000.0 -0.53 53720.0 -35200.0 -0.56 -0.7694 -0.9995 1009854 TimTec1_001608 COc1ccc(cc1)C(O)C(=O)c2ccc(OC)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J03 compound treatment 39040.0 -39000.0 -0.64 43040.0 -45900.0 -0.73 -0.9724 -0.998 3082941 TimTec1_001609 Cc1sc(/N=C/c2ccc(Br)s2)c(C(=O)N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J04 compound treatment 93720.0 15600.0 0.26 111640.0 22700.0 0.36 0.439 0.9862 1144212 TimTec1_001610 OC(=O)c1ccc2OCCOCCOCCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J05 compound treatment 45800.0 -32300.0 -0.53 59840.0 -29100.0 -0.46 -0.7042 -0.9976 3210921 TimTec1_001611 Cc1nnc(/N=C/2\S/C(=C/c3ccccc3F)/C(=O)N2CC=C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J06 compound treatment 66680.0 -11400.0 -0.19 92160.0 3270.0 0.05 -0.0962 -0.4929 1115371 TimTec1_001612 COc1ccc(cc1)C(N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J07 compound treatment 32440.0 -45600.0 -0.75 32920.0 -56000.0 -0.89 -1.1635 -0.9965 3083016 TimTec1_001613 Brc1ccc(cc1)N2C(=O)C3ON(C(/C=C/c4ccccc4)C3C2=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J08 compound treatment 108680.0 30600.0 0.51 105360.0 16500.0 0.26 0.5428 0.9535 1351925 TimTec1_001614 CCOC(=O)c1[nH]c(C(=O)O)c(C(=O)OCc2ccccc2)c1CCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J09 compound treatment 102560.0 24500.0 0.4 94440.0 5550.0 0.09 0.3483 0.8419 3083019 TimTec1_001615 COc1cccc(/N=C/C2=C3N(CCC2)c4ccccc4C3(C)C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J10 compound treatment 83720.0 5640.0 0.09 96400.0 7510.0 0.12 0.1505 0.9923 1286584 TimTec1_001616 O=C(NCCc1c[nH]c2ccc(OCc3ccccc3)cc12)C4CCCNC4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J11 compound treatment 30480.0 -47600.0 -0.79 33120.0 -55800.0 -0.89 -1.1841 -0.9981 1208195 TimTec1_001617 NNC(=O)c1cc(n[nH]1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J12 compound treatment 120200.0 42100.0 0.7 120080.0 31200.0 0.5 0.8432 0.9865 3083022 TimTec1_001618 CC(N)(Cc1ccc2OCOc2c1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J13 compound treatment 99920.0 21800.0 0.36 119520.0 30600.0 0.49 0.6001 0.9889 3210922 TimTec1_001619 CN(C)c1ccc(/C=C\2/C(=NN(C2=O)c3nnc(C)c(=O)[nH]3)C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J14 compound treatment 40680.0 -37400.0 -0.62 52240.0 -36700.0 -0.58 -0.8496 -0.9996 1414476 TimTec1_001620 Cc1ccc(NC(=O)c2cccc3-c4ccccc4C(=O)c32)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J15 compound treatment 6400.0 -71700.0 -1.18 7040.0 -81900.0 -1.3 -1.7591 -0.9988 1395626 TimTec1_001621 CC1C(=O)CCC2C(C)(COc3ccc4ccc(=O)oc4c3)CCCC12C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J16 compound treatment 81080.0 3000.0 0.05 93320.0 4430.0 0.07 0.0849 0.9851 1361860 TimTec1_001622 CC1(C)COC(OC1)c2ccc(O)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J17 compound treatment 72120.0 -5960.0 -0.1 67720.0 -21200.0 -0.34 -0.3082 -0.8767 3083025 TimTec1_001623 CC(=CC(=O)Nc1ccc(Cl)cc1)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J18 compound treatment 68360.0 -9720.0 -0.16 79960.0 -8930.0 -0.14 -0.2141 -0.9982 3210923 TimTec1_001624 COc1ccccc1C(=O)N(C(C)C)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J19 compound treatment 70440.0 -7640.0 -0.13 74800.0 -14100.0 -0.22 -0.248 -0.9627 1015339 TimTec1_001625 OC(c1ccccc1)C(O)(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J20 compound treatment 101200.0 23100.0 0.38 106280.0 17400.0 0.28 0.4659 0.9876 1921357 TimTec1_001626 Brc1ccccc1C2OCC3(CO2)COC(OC3)c4ccccc4Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J21 compound treatment 36280.0 -41800.0 -0.69 41000.0 -47900.0 -0.76 -1.0276 -0.9987 3083029 TimTec1_001627 C[C@]1(CCC[C@]2(C)[C@H]3CC(O)[C@](C)(C=C)C=C3CC[C@@H]12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J22 compound treatment 71880.0 -6200.0 -0.1 88000.0 -894.0 -0.01 -0.0824 -0.7979 1236876 TimTec1_001628 OCCC1(C(=O)c2ccccc2C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J23 mock treatment 94480.0 16400.0 0.27 104160.0 15300.0 0.24 0.3635 0.9986 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 J24 mock treatment 60640.0 -17400.0 -0.29 80120.0 -8770.0 -0.14 -0.3024 -0.945 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K01 compound treatment 31560.0 -46500.0 -0.77 34680.0 -54200.0 -0.86 -1.154 -0.9983 1634606 TimTec1_001629 CCn1c(=O)c2C(=Nc3cc(C)ccc3Oc2c4ccccc14)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K02 compound treatment 31240.0 -46800.0 -0.77 40160.0 -48700.0 -0.78 -1.0959 -1.0 3083031 TimTec1_001630 COc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K03 compound treatment 35960.0 -42100.0 -0.7 43760.0 -45100.0 -0.72 -1.0003 -0.9999 3210924 TimTec1_001631 COc1ccc(cc1)C2CC(=NC(=N)N2)c3cc(OC)cc(OC)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K04 compound treatment 56880.0 -21200.0 -0.35 68520.0 -20400.0 -0.32 -0.477 -0.9993 3210925 TimTec1_001632 OC(=O)c1cccc(c1)c2ccc(/C=N\n3cnnc3)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K05 compound treatment 21880.0 -56200.0 -0.93 28680.0 -60200.0 -0.96 -1.3346 -0.9999 1250333 TimTec1_001633 CCOC(=O)CSc1cc(Cl)c2cccc(C)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K06 compound treatment 57600.0 -20500.0 -0.34 79040.0 -9850.0 -0.16 -0.3501 -0.9392 1029874 TimTec1_001634 CCOC(=O)C1(O)c2ccccc2-c3ccccc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K07 compound treatment 45160.0 -32900.0 -0.54 43880.0 -45000.0 -0.72 -0.8915 -0.9906 1426581 TimTec1_001635 CC(C)c1cc(NC(=O)c2ccccc2)c(C)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K08 compound treatment 59720.0 -18400.0 -0.3 66520.0 -22400.0 -0.36 -0.4664 -0.9967 1278979 TimTec1_001636 CN(C)c1ccc(NC(=O)c2sc(=S)[nH]c2N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K09 compound treatment 85120.0 7040.0 0.12 81280.0 -7610.0 -0.12 -0.0036 -0.0214 3083036 TimTec1_001637 OC(=O)/C=C\C(=O)N1CCN(Cc2ccc3OCOc3c2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K10 compound treatment 33840.0 -44200.0 -0.73 42760.0 -46100.0 -0.74 -1.0363 -1.0 1138966 TimTec1_001638 O=C(NC1CCCCC1)c2c[nH]c3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K11 compound treatment 5240.0 -72800.0 -1.2 5000.0 -83900.0 -1.34 -1.7957 -0.9986 3210926 TimTec1_001639 CN(C1CCCCC1)C(=O)CCCOc2ccc(Cl)cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K12 compound treatment 34480.0 -43600.0 -0.72 39240.0 -49700.0 -0.79 -1.0685 -0.9989 1449748 TimTec1_001640 Fc1ccc(cc1)C2C(C3C=Cc4ccccc4N3C2(C#N)C#N)C(=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K13 compound treatment 91160.0 13100.0 0.22 101080.0 12200.0 0.19 0.2901 0.9986 3083110 TimTec1_001641 CS(=O)(=O)c1ccc(s1)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K14 compound treatment 6280.0 -71800.0 -1.19 7560.0 -81300.0 -1.3 -1.7547 -0.999 1649383 TimTec1_001642 Cc1ccc(s1)C2C3CCCC=C3C(C#N)C(N)C2(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K15 compound treatment 49080.0 -29000.0 -0.48 65880.0 -23000.0 -0.37 -0.5978 -0.9914 3083113 TimTec1_001643 CC1(C)C(c2nc(no2)c3ccc(Br)cc3)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K16 compound treatment 5640.0 -72400.0 -1.2 6440.0 -82500.0 -1.31 -1.7748 -0.9989 1072463 TimTec1_001644 Oc1ccc(cc1)C(c2ccc(O)cc2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K17 compound treatment 63160.0 -14900.0 -0.25 72680.0 -16200.0 -0.26 -0.3568 -0.9997 3083115 TimTec1_001645 COc1cc(/C=N/c2nonc2NC(=O)C)ccc1OC(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K18 compound treatment 65280.0 -12800.0 -0.21 64560.0 -24300.0 -0.39 -0.4236 -0.9592 1266444 TimTec1_001646 OC(=O)c1ccc(COc2ccccc2)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K19 compound treatment 39440.0 -38600.0 -0.64 42280.0 -46600.0 -0.74 -0.9763 -0.9971 1199220 TimTec1_001647 COc1ccc(cc1)C2C(C(=O)N)C2(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K20 compound treatment 78680.0 604.0 0.01 88280.0 -614.0 -0.01 1.0E-4 0.0093 3083117 TimTec1_001648 CCNC(=S)Nc1c(C)cccc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K21 compound treatment 56640.0 -21400.0 -0.35 77280.0 -11600.0 -0.19 -0.3811 -0.9543 3210927 TimTec1_001649 O=C/1/C(=C/c2cccc3OCOc32)/CCC\C1=C/c4cccc5OCOc54 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K22 compound treatment 67480.0 -10600.0 -0.17 80080.0 -8810.0 -0.14 -0.223 -0.9941 1204849 TimTec1_001650 Oc1ccc2c(=O)c(coc2c1CN3CCCCC3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K23 mock treatment 70120.0 -7960.0 -0.13 76160.0 -12700.0 -0.2 -0.2364 -0.9778 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 K24 mock treatment 46680.0 -31400.0 -0.52 54320.0 -34600.0 -0.55 -0.7561 -0.9995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L01 compound treatment 38120.0 -40000.0 -0.66 42440.0 -46500.0 -0.74 -0.9899 -0.9983 1427041 TimTec1_001651 C(Cn1c2ccccc2c3ccccc13)c4nc5ccccc5[nH]4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L02 compound treatment 58480.0 -19600.0 -0.32 71680.0 -17200.0 -0.27 -0.4227 -0.9966 1045556 TimTec1_001652 COc1ccc2[n+]([O-])cccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L03 compound treatment 69920.0 -8160.0 -0.13 78360.0 -10500.0 -0.17 -0.2139 -0.994 3210928 TimTec1_001653 O=C(N1CCN(CC1)C2=NC(=O)/C(=C/c3cccs3)/S2)c4cc5ccccc5oc4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L04 compound treatment 65120.0 -13000.0 -0.21 90560.0 1670.0 0.03 -0.1325 -0.6146 3083122 TimTec1_001654 COc1ccc(/C=C/C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L05 compound treatment 5000.0 -73100.0 -1.21 6040.0 -82900.0 -1.32 -1.7868 -0.999 1566626 TimTec1_001655 Fc1ccc(cc1)C(CC(=O)c2cccs2)SCc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L06 compound treatment 74320.0 -3760.0 -0.06 94760.0 5870.0 0.09 0.0223 0.1985 1449697 TimTec1_001656 CC1Cc2cc(OCC(=O)O)ccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L07 compound treatment 65360.0 -12700.0 -0.21 70760.0 -18100.0 -0.29 -0.3528 -0.9877 3083124 TimTec1_001657 NC1=Cc2ccccc2CN1c3ccccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L08 compound treatment 69720.0 -8360.0 -0.14 79480.0 -9410.0 -0.15 -0.2036 -0.9991 3210929 TimTec1_001658 COc1ccc(cc1)N2CC(=O)N(/N=C/c3ccccc3C(=O)O)C2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L09 compound treatment 67600.0 -10500.0 -0.17 82960.0 -5930.0 -0.09 -0.1892 -0.9597 1667441 TimTec1_001659 NC(=O)c1ccccc1NC(=O)C2COc3ccccc3O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L10 compound treatment 4080.0 -74000.0 -1.22 4280.0 -84600.0 -1.35 -1.8173 -0.9988 1921446 TimTec1_001660 CC1=CC(=O)N(CCc2c[nH]c3ccc(OCc4ccccc4)cc23)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L11 compound treatment 4720.0 -73400.0 -1.21 7080.0 -81800.0 -1.3 -1.7783 -0.9993 1703270 TimTec1_001661 Nc1c(C#N)c2nc(C#N)c(C#N)nc2n1Cc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L12 compound treatment 4160.0 -73900.0 -1.22 4520.0 -84400.0 -1.34 -1.8137 -0.9988 1414477 TimTec1_001662 CC(C)Cc1ccc(cc1)C(C)C(=O)NCCc2c[nH]c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L13 compound treatment 50400.0 -27700.0 -0.46 46360.0 -42500.0 -0.68 -0.8024 -0.9815 1436746 TimTec1_001663 Nc1c(C#N)c2nc(C#N)c(C#N)nc2n1CCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L14 compound treatment 77720.0 -356.0 -0.01 89560.0 666.0 0.01 0.0034 0.276 1148985 TimTec1_001664 CCCCC1(SCCS1)c2cc(O)cc(O)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L15 compound treatment 60880.0 -17200.0 -0.28 69760.0 -19100.0 -0.3 -0.4164 -0.9994 3083129 TimTec1_001665 Nc1cccc(c1)C2=NCCN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L16 compound treatment 54960.0 -23100.0 -0.38 60800.0 -28100.0 -0.45 -0.5864 -0.9968 3211052 TimTec1_001666 CNC(=S)Nc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L17 compound treatment 63960.0 -14100.0 -0.23 80480.0 -8410.0 -0.13 -0.2596 -0.9656 3083131 TimTec1_001667 Cc1nc2ccc(Cl)cc2n1CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L18 compound treatment 6080.0 -72000.0 -1.19 7120.0 -81800.0 -1.3 -1.762 -0.9989 1188527 TimTec1_001668 CN1CCCc2cc(ccc12)c3ccnc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L19 compound treatment 87200.0 9120.0 0.15 93840.0 4950.0 0.08 0.1622 0.9544 3211053 TimTec1_001669 CC(C)/C=c\1/[nH]c(=O)/c(=C/c2ccccc2)/[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L20 compound treatment 77560.0 -516.0 -0.01 77880.0 -11000.0 -0.18 -0.1302 -0.7406 3083134 TimTec1_001670 CCOC(=O)c1sc(NC(=O)C)c(C#N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L21 compound treatment 63680.0 -14400.0 -0.24 72720.0 -16200.0 -0.26 -0.3503 -0.9992 3211054 TimTec1_001671 CC[C@H]1[C@@H]2OC(=O)[C@@H](C)[C@@H]2[C@H]3C[C@@H]([C@@H]4C[C@H](C)C(=O)O4)N5CCCC[C@H]1[C@H]35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L22 compound treatment 49720.0 -28400.0 -0.47 55680.0 -33200.0 -0.53 -0.7053 -0.9981 1341798 TimTec1_001672 O=C(Nc1ccccc1)OCC2(C(=O)c3ccccc3C2=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L23 mock treatment 64360.0 -13700.0 -0.23 82640.0 -6250.0 -0.1 -0.2306 -0.9321 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 L24 mock treatment 52880.0 -25200.0 -0.42 63440.0 -25500.0 -0.41 -0.581 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M01 compound treatment 48000.0 -30100.0 -0.5 44880.0 -44000.0 -0.7 -0.8471 -0.9857 3083213 TimTec1_001673 C[C@@]1(CCC[C@@]2(C)[C@H]1CCc3ccc(O)cc32)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M02 compound treatment 40320.0 -37800.0 -0.62 54920.0 -34000.0 -0.54 -0.8236 -0.9975 3211055 TimTec1_001674 Clc1ccc(cc1)C(CC(=O)c2ccc(Br)cc2)C3CCCCC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M03 compound treatment 3360.0 -74700.0 -1.23 4000.0 -84900.0 -1.35 -1.8289 -0.9989 3083215 TimTec1_001675 COc1ccc2CCC3[C@@](C)(CO)CCC[C@]3(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M04 compound treatment 42640.0 -35400.0 -0.58 59520.0 -29400.0 -0.47 -0.7447 -0.9939 3211056 TimTec1_001676 COc1cc(/C=N\n2nnnc2N)cc(Cl)c1OCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M05 compound treatment 61000.0 -17100.0 -0.28 74760.0 -14100.0 -0.23 -0.3586 -0.9938 1459549 TimTec1_001677 C=CCCN1C[C@@H]2CC(C1)c3cccc(=O)n3C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M06 compound treatment 42200.0 -35900.0 -0.59 57160.0 -31700.0 -0.51 -0.7764 -0.9969 1091851 TimTec1_001678 CC1=C(SCCO1)C(=O)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M07 compound treatment 49000.0 -29100.0 -0.48 56600.0 -32300.0 -0.51 -0.7033 -0.9994 3083218 TimTec1_001679 OCn1nc(oc1=S)c2ccc(Cl)cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M08 compound treatment 15440.0 -62600.0 -1.03 21880.0 -67000.0 -1.07 -1.4864 -0.9999 3211058 TimTec1_001680 CN(C)c1ccc(cc1)N/2CC(=O)S\C2=N\C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M09 compound treatment 63080.0 -15000.0 -0.25 74320.0 -14600.0 -0.23 -0.3393 -0.9995 1163310 TimTec1_001681 CN(C(=O)CSc1ccccc1C(=O)O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M10 compound treatment 3800.0 -74300.0 -1.23 6120.0 -82800.0 -1.32 -1.7999 -0.9993 1289766 TimTec1_001682 Cc1ccccc1NC(=O)c2c[nH]c3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M11 compound treatment 17240.0 -60800.0 -1.0 21680.0 -67200.0 -1.07 -1.4676 -0.9995 3211059 TimTec1_001683 O=C/1ON=C(\C1=C\C=C\c2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M12 compound treatment 8080.0 -70000.0 -1.16 6600.0 -82300.0 -1.31 -1.7445 -0.998 1227323 TimTec1_001684 O=C(C1C(c2cccnc2)C(C#N)(C#N)C3C=Cc4ccccc4N13)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M13 compound treatment 53640.0 -24400.0 -0.4 56640.0 -32300.0 -0.51 -0.6487 -0.9928 1914043 TimTec1_001685 CCSc1sc(CN(C)C)cc1/C=N/O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M14 compound treatment 38920.0 -39200.0 -0.65 62400.0 -26500.0 -0.42 -0.7556 -0.9787 1340838 TimTec1_001686 CCOC(=O)C1=C(N)Oc2[nH]nc(C)c2C1c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M15 compound treatment 45560.0 -32500.0 -0.54 75200.0 -13700.0 -0.22 -0.5339 -0.9214 1362482 TimTec1_001687 Nc1nonc1NC(=O)CSc2ncccc2C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M16 compound treatment 47560.0 -30500.0 -0.5 50000.0 -38900.0 -0.62 -0.7945 -0.9947 1375046 TimTec1_001688 NNC(=O)CSCc1ccc(Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M17 compound treatment 74400.0 -3680.0 -0.06 98160.0 9270.0 0.15 0.0615 0.3853 1460899 TimTec1_001689 CC(=O)Nc1nonc1N2CCCC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M18 compound treatment 62600.0 -15500.0 -0.26 69920.0 -19000.0 -0.3 -0.3945 -0.9965 1065783 TimTec1_001690 CNC(=S)Nc1ccc(C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M19 compound treatment 103880.0 25800.0 0.43 108680.0 19800.0 0.32 0.5242 0.9891 1042406 TimTec1_001691 Clc1ccc(NC(=O)NC2CCCCC2)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M20 compound treatment 84520.0 6440.0 0.11 83080.0 -5810.0 -0.09 0.0097 0.0687 1082102 TimTec1_001692 COc1ccc(NC(=S)Nc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M21 compound treatment 5040.0 -73000.0 -1.21 4800.0 -84100.0 -1.34 -1.8003 -0.9986 3211060 TimTec1_001693 CN1C/C(=C\c2ccccc2C)/C(=O)\C(=C\c3ccccc3C)\C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M22 compound treatment 57000.0 -21100.0 -0.35 59080.0 -29800.0 -0.48 -0.582 -0.9883 3083226 TimTec1_001694 O=C(/C(=C\1/NC(=O)c2ccccc2N1)/C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M23 mock treatment 75440.0 -2640.0 -0.04 97440.0 8550.0 0.14 0.0655 0.4584 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 M24 mock treatment 64080.0 -14000.0 -0.23 63520.0 -25400.0 -0.4 -0.4493 -0.9647 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N01 compound treatment 46880.0 -31200.0 -0.51 70480.0 -18400.0 -0.29 -0.5717 -0.9645 1397605 TimTec1_001695 Cc1ccc(cc1)N(C2CCS(=O)(=O)C2)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N02 compound treatment 59240.0 -18800.0 -0.31 24280.0 -64600.0 -1.03 -0.9481 -0.8813 1024491 TimTec1_001696 COC(=O)c1ccc(=O)oc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N03 compound treatment 52240.0 -25800.0 -0.43 17240.0 -71700.0 -1.14 -1.1091 -0.9098 3211061 TimTec1_001697 O=C(CCCN1C(=O)S/C(=C/c2ccccc2)/C1=S)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N04 compound treatment 79840.0 1760.0 0.03 80120.0 -8770.0 -0.14 -0.0783 -0.5481 3083229 TimTec1_001698 Brc1cccc(c1)C(=O)C2=CC3Cc4ccccc4C3C=C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N05 compound treatment 57760.0 -20300.0 -0.34 69840.0 -19100.0 -0.3 -0.4519 -0.9988 1440003 TimTec1_001699 CCc1cc(c2n[nH]c(CCC(=O)O)c2c3nc4ccccc4n3C)c(O)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N06 compound treatment 59400.0 -18700.0 -0.31 69800.0 -19100.0 -0.3 -0.4332 -1.0 3083231 TimTec1_001700 OC(=O)C1(SCCCS1)C2CCC3OCOC3C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N07 compound treatment 41240.0 -36800.0 -0.61 62240.0 -26700.0 -0.42 -0.7304 -0.9846 1108575 TimTec1_001701 C[N+](=Cc1ccc(C#N)cc1)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N08 compound treatment 33480.0 -44600.0 -0.74 43280.0 -45600.0 -0.73 -1.0346 -1.0 1363444 TimTec1_001702 OC(CN1C(=O)c2ccccc2C1=O)CN3CCN(CC3)c4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N09 compound treatment 9040.0 -69000.0 -1.14 10920.0 -78000.0 -1.24 -1.6846 -0.9991 1864240 TimTec1_001703 COc1cc(/C=C(\C#N)/c2ccc(Cl)cc2)ccc1OC(=O)C3COc4ccccc4O3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N10 compound treatment 47640.0 -30400.0 -0.5 67360.0 -21500.0 -0.34 -0.598 -0.9827 3082142 TimTec1_001704 CC(=O)O/C(=C\c1cn(C(=O)C)c2ccccc12)/C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N11 compound treatment 3840.0 -74200.0 -1.23 7640.0 -81300.0 -1.3 -1.7823 -0.9996 1722000 TimTec1_001705 Cc1cccc(c1)N2C(=O)c3sc4nccc(=O)n4c3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N12 compound treatment 4680.0 -73400.0 -1.21 4600.0 -84300.0 -1.34 -1.8067 -0.9987 1517994 TimTec1_001706 Cc1c[nH]c2cccc(OCC(O)CN3CCN(CC3)C(c4ccccc4)c5ccccc5)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N13 compound treatment 98280.0 20200.0 0.33 98640.0 9750.0 0.16 0.3457 0.9395 3082144 TimTec1_001707 Fc1ccc(NC(=O)CSc2nnc3ccccn23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N14 compound treatment 44880.0 -33200.0 -0.55 52040.0 -36900.0 -0.59 -0.8028 -0.9994 1606324 TimTec1_001708 CN(C)c1nc2ccc(OCCN3CCOCC3)cc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N15 compound treatment 51240.0 -26800.0 -0.44 63960.0 -24900.0 -0.4 -0.5943 -0.9985 3082146 TimTec1_001709 CC(CC(=O)O)n1ccnc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N16 compound treatment 51680.0 -26400.0 -0.44 53320.0 -35600.0 -0.57 -0.709 -0.9915 3211063 TimTec1_001710 CCNC(=S)Nc1ccc(F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N17 compound treatment 63680.0 -14400.0 -0.24 67160.0 -21700.0 -0.35 -0.413 -0.9831 3082148 TimTec1_001711 C(CSc1nc2ccccc2o1)Sc3nc4ccccc4o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N18 compound treatment 46880.0 -31200.0 -0.51 54880.0 -34000.0 -0.54 -0.7475 -0.9997 1722403 TimTec1_001712 OC(OCC1Cc2ccccc2O1)C3Cc4ccccc4O3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N19 compound treatment 75800.0 -2280.0 -0.04 72880.0 -16000.0 -0.26 -0.207 -0.8026 3211064 TimTec1_001713 COc1ccc(/C=c/2\[nH]c(=O)\c(=C/c3ccc(OC)cc3)\[nH]c2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N20 compound treatment 5720.0 -72400.0 -1.19 5080.0 -83800.0 -1.34 -1.7892 -0.9984 1707203 TimTec1_001714 Cc1cccc(Nc2nc3nonc3nc2Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N21 compound treatment 52040.0 -26000.0 -0.43 71520.0 -17400.0 -0.28 -0.4997 -0.9774 3211065 TimTec1_001715 CC(C)(C)C1(O)C=C(O)C(=O)N1c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N22 compound treatment 74480.0 -3600.0 -0.06 79480.0 -9410.0 -0.15 -0.1481 -0.9177 1565579 TimTec1_001716 O=C(OCCC1(C(=O)c2ccccc2C1=O)c3ccccc3)c4cc5ccccc5oc4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N23 mock treatment 70560.0 -7520.0 -0.12 69040.0 -19900.0 -0.32 -0.3115 -0.9164 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 N24 mock treatment 70320.0 -7760.0 -0.13 77840.0 -11100.0 -0.18 -0.2151 -0.9877 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O01 compound treatment 33920.0 -44200.0 -0.73 36520.0 -52400.0 -0.83 -1.1057 -0.9977 3211066 TimTec1_001717 CC1=C(C)C2C(=NC(=NC2=O)c3ccc(o3)c4ccc(cc4)C(=O)O)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O02 compound treatment 34280.0 -43800.0 -0.72 33440.0 -55500.0 -0.88 -1.1362 -0.995 3082153 TimTec1_001718 CCOC(=O)c1[nH]c(C)c(CC(C)C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O03 compound treatment 40840.0 -37200.0 -0.61 38760.0 -50100.0 -0.8 -0.9997 -0.9916 1487341 TimTec1_001719 COc1ccc(NC(c2ccc(C)cc2)n3ncc4c(=O)n(C)c5ccccc5c34)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O04 compound treatment 17720.0 -60400.0 -1.0 19440.0 -69500.0 -1.11 -1.4873 -0.9986 3082155 TimTec1_001720 Cc1sc2NC(NC(=O)c2c1C)/C=C/c3ccc4OCOc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O05 compound treatment 47240.0 -30800.0 -0.51 54760.0 -34100.0 -0.54 -0.7446 -0.9994 3211067 TimTec1_001721 CC[C@H]1CN2CCC3(C2C[C@@H]1/C(=C\OC)/C(=O)OC)C(=O)Nc4ccccc43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O06 compound treatment 50680.0 -27400.0 -0.45 65200.0 -23700.0 -0.38 -0.5868 -0.996 1300191 TimTec1_001722 C(Nc1ncnc2nc[nH]c12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O07 compound treatment 33640.0 -44400.0 -0.73 26680.0 -62200.0 -0.99 -1.2198 -0.989 3211068 TimTec1_001723 Cc1nn(c(C)c1/N=C/c2c(O)ccc3ccccc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O08 compound treatment 36920.0 -41200.0 -0.68 28000.0 -60900.0 -0.97 -1.1667 -0.9848 1782754 TimTec1_001724 OC(=O)c1c[nH]c2ccccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O09 compound treatment 35320.0 -42800.0 -0.71 45920.0 -43000.0 -0.68 -0.9834 -0.9999 1165165 TimTec1_001725 C=CCn1nnnc1SCc2cccc(CSc3nnnn3CC=C)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O10 compound treatment 50240.0 -27800.0 -0.46 52920.0 -36000.0 -0.57 -0.7303 -0.994 1284834 TimTec1_001726 CCc1ccccc1NC(=O)c2c[nH]c3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O11 compound treatment 51400.0 -26700.0 -0.44 51960.0 -36900.0 -0.59 -0.7276 -0.9898 3209092 TimTec1_001727 OC(=O)c1ccc(N/C=C/2\C(=O)ON=C2c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O12 compound treatment 75760.0 -2320.0 -0.04 82640.0 -6250.0 -0.1 -0.0975 -0.9134 1145898 TimTec1_001728 Nc1nc2CCCCCc2c(c1C#N)c3cccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O13 compound treatment 74400.0 -3680.0 -0.06 87920.0 -974.0 -0.02 -0.0539 -0.8603 3209093 TimTec1_001729 Cc1cc(C(=O)O)c(s1)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O14 compound treatment 51320.0 -26800.0 -0.44 72120.0 -16800.0 -0.27 -0.5014 -0.9711 1667092 TimTec1_001730 COc1ccc(cc1)c2c[nH]c(=N)s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O15 compound treatment 42520.0 -35600.0 -0.59 56160.0 -32700.0 -0.52 -0.7839 -0.9983 1602686 TimTec1_001731 Nc1nonc1NC(=O)CSC2=NCCS2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O16 compound treatment 42320.0 -35800.0 -0.59 51000.0 -37900.0 -0.6 -0.8444 -0.9999 1216965 TimTec1_001732 COc1ccc(cc1OC)S(=O)(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O17 compound treatment 50560.0 -27500.0 -0.45 54080.0 -34800.0 -0.55 -0.7135 -0.9951 3209094 TimTec1_001733 CC(=O)Nc1nonc1Nc2csc(CC#N)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O18 compound treatment 44560.0 -33500.0 -0.55 56760.0 -32100.0 -0.51 -0.7534 -0.9993 3082865 TimTec1_001734 Cc1cccc(C)c1NS(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O19 compound treatment 3960.0 -74100.0 -1.22 4360.0 -84500.0 -1.35 -1.8178 -0.9988 3209095 TimTec1_001735 OC(=O)Nc1cc(Cl)cc(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O20 compound treatment 54320.0 -23800.0 -0.39 43280.0 -45600.0 -0.73 -0.7914 -0.958 3082867 TimTec1_001736 OC(=O)c1ccc(/N=C/c2ccc(o2)c3ccc(Cl)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O21 compound treatment 4600.0 -73500.0 -1.21 4640.0 -84300.0 -1.34 -1.8072 -0.9987 1913174 TimTec1_001737 CN1C/C(=C\c2ccc3OCOc3c2)/C(=O)\C(=C\c4ccc5OCOc5c4)\C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O22 compound treatment 71720.0 -6360.0 -0.1 79160.0 -9730.0 -0.16 -0.1839 -0.9819 1594528 TimTec1_001738 NC(=O)c1ccc(OC2CSC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O23 mock treatment 65040.0 -13000.0 -0.22 73000.0 -15900.0 -0.25 -0.3313 -0.9967 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 O24 mock treatment 53040.0 -25000.0 -0.41 62680.0 -26200.0 -0.42 -0.5877 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P01 compound treatment 43840.0 -34200.0 -0.57 50320.0 -38600.0 -0.61 -0.8344 -0.9991 1562676 TimTec1_001739 S=c1oc(Cc2ccccc2)nn1CN3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P02 compound treatment 61880.0 -16200.0 -0.27 64280.0 -24600.0 -0.39 -0.4665 -0.9825 1066227 TimTec1_001740 CC(=O)Nc1nc(C)cs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P03 compound treatment 36200.0 -41900.0 -0.69 48000.0 -40900.0 -0.65 -0.9497 -0.9996 3209096 TimTec1_001741 Cc1cc(C(=O)CSc2nnc3ccccn23)c(C)n1c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P04 compound treatment 48400.0 -29700.0 -0.49 64960.0 -23900.0 -0.38 -0.6161 -0.9923 1472764 TimTec1_001742 OCCNC(=O)c1ccc2OCCOCCOCCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P05 compound treatment 36880.0 -41200.0 -0.68 46600.0 -42300.0 -0.67 -0.9575 -1.0 1707455 TimTec1_001743 C(N1CCCc2ccccc12)c3cn4ccccc4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P06 compound treatment 3120.0 -75000.0 -1.24 2800.0 -86100.0 -1.37 -1.8452 -0.9987 1631427 TimTec1_001744 COc1ccc2c(CCC3=C(C)C(=O)CCC32C)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P07 compound treatment 10760.0 -67300.0 -1.11 18920.0 -70000.0 -1.12 -1.5744 -1.0 1684686 TimTec1_001745 N1C(Nc2cccc3cccc1c23)c4ccncc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P08 compound treatment 18760.0 -59300.0 -0.98 21960.0 -66900.0 -1.07 -1.4467 -0.9991 1244779 TimTec1_001746 C(OCc1ccccc1)C(CSc2ccccc2)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P09 compound treatment 2720.0 -75400.0 -1.24 2440.0 -86500.0 -1.38 -1.8539 -0.9987 3082946 TimTec1_001747 Clc1ccccc1/C=C/C(=O)Nc2nnc[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P10 compound treatment 12040.0 -66000.0 -1.09 11520.0 -77400.0 -1.23 -1.6428 -0.9981 3209097 TimTec1_001748 O=C/1OC(=N\C1=C/c2c[nH]c3ccccc23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P11 compound treatment 3000.0 -75100.0 -1.24 3560.0 -85300.0 -1.36 -1.838 -0.9989 1718471 TimTec1_001749 CCCc1cc(=O)n2c3C(=O)N(Cc4ccccc4)C(=O)c3sc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P12 compound treatment 38040.0 -40000.0 -0.66 32640.0 -56300.0 -0.9 -1.1013 -0.9887 1434439 TimTec1_001750 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P13 compound treatment 71120.0 -6960.0 -0.11 61120.0 -27800.0 -0.44 -0.3942 -0.862 3209098 TimTec1_001751 Cc1nnc(C)n1/N=C/C=C\c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P14 compound treatment 49000.0 -29100.0 -0.48 60560.0 -28300.0 -0.45 -0.6587 -0.9995 1284591 TimTec1_001752 CS(=O)(=O)Cc1ccc(Oc2ccc(NS(=O)(=O)C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P15 compound treatment 4240.0 -73800.0 -1.22 4120.0 -84800.0 -1.35 -1.8173 -0.9987 1689423 TimTec1_001753 COc1cc-2c(CC3N(C)CCc4c(OC)c(OC)c(OC)c2c34)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P16 compound treatment 37920.0 -40200.0 -0.66 45840.0 -43100.0 -0.69 -0.9539 -0.9999 3082952 TimTec1_001754 CCNC(=S)N1CCOCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P17 compound treatment 51040.0 -27000.0 -0.45 55080.0 -33800.0 -0.54 -0.6967 -0.9956 1735540 TimTec1_001755 CCCCn1c(=O)oc2cc(Br)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P18 compound treatment 3080.0 -75000.0 -1.24 2960.0 -85900.0 -1.37 -1.8439 -0.9987 3209099 TimTec1_001756 FC(F)(F)c1cccc(NC(=O)CSc2cccc3cccnc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P19 compound treatment 41800.0 -36300.0 -0.6 42480.0 -46400.0 -0.74 -0.9465 -0.9945 3082954 TimTec1_001757 CCN1CC(=O)N(C1=S)c2ccccc2OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P20 compound treatment 49280.0 -28800.0 -0.48 57640.0 -31300.0 -0.5 -0.6884 -0.9997 1412266 TimTec1_001758 CC(=O)n1c2ccc(C)cc2c3nc4ccccc4nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P21 compound treatment 55320.0 -22800.0 -0.38 73760.0 -15100.0 -0.24 -0.4362 -0.9771 3209100 TimTec1_001759 Cc1cn(C2CC(NC(=O)C(C)(C)C)C(CO)O2)c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P22 compound treatment 24440.0 -53600.0 -0.89 26600.0 -62300.0 -0.99 -1.3281 -0.9984 1065752 TimTec1_001760 O=C1C(=Cc2c[nH]c3ccccc23)C(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P23 mock treatment 59840.0 -18200.0 -0.3 54560.0 -34300.0 -0.55 -0.5998 -0.9604 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2067 P24 mock treatment 65880.0 -12200.0 -0.2 76160.0 -12700.0 -0.2 -0.2859 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A01 compound treatment 156480.0 17300.0 0.29 153400.0 27800.0 0.44 0.5157 0.9777 1440335 TimTec1_002465 COc1ccc2N(C(=O)CN3C(=O)CCC3=O)C(C)(C)C=C(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A02 compound treatment 168040.0 28900.0 0.48 116760.0 -8840.0 -0.14 0.2377 0.4778 3210671 TimTec1_002466 Oc1ccccc1/C=N/c2ccc(cc2)C(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A03 compound treatment 161400.0 22300.0 0.37 74920.0 -50700.0 -0.81 -0.3114 -0.3508 1235611 TimTec1_002467 CCSc1nc2ccc(NC(=O)c3ccccc3C(=O)O)cc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A04 compound treatment 130720.0 -8420.0 -0.14 74800.0 -50800.0 -0.81 -0.6708 -0.8165 3210672 TimTec1_002468 CC(NC(=O)/C=C/c1cccc2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A05 compound treatment 220240.0 81100.0 1.34 160040.0 34400.0 0.55 1.3348 0.9225 3210673 TimTec1_002469 C[S+](C)c1c(O)n(CCc2ccc(F)cc2)c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A06 compound treatment 212720.0 73600.0 1.21 155400.0 29800.0 0.47 1.1947 0.916 3083610 TimTec1_002470 COC(=O)COc1c(C)cc(Br)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A07 compound treatment 184160.0 45000.0 0.74 111480.0 -14100.0 -0.23 0.3663 0.4718 3210674 TimTec1_002471 Oc1cc(=O)n(n2c(=O)cc(O)n(c3ccccc3)c2=S)c(=S)n1c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A08 compound treatment 175520.0 36400.0 0.6 77880.0 -47700.0 -0.76 -0.1132 -0.1168 1664815 TimTec1_002472 Cn1c(Cl)c(CN)c2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A09 compound treatment 39920.0 -99200.0 -1.64 18160.0 -107000.0 -1.71 -2.369 -0.9998 3083613 TimTec1_002473 CCOC(=O)c1cc(C(=O)c2ccc(Cl)cc2)n3c1ccc4ccccc43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A10 compound treatment 125360.0 -13800.0 -0.23 52760.0 -72800.0 -1.16 -0.9818 -0.8298 3210675 TimTec1_002474 COc1ccc2ccccc2c1/C=N/c3ccc(C)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A11 compound treatment 184400.0 45300.0 0.75 125280.0 -324.0 -0.01 0.5247 0.7022 3210676 TimTec1_002475 Cc1ccc(cc1)N2C(=O)NC(=O)/C(=C/NCCC3=CCCCC3)/C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A12 compound treatment 145280.0 6140.0 0.1 107280.0 -18300.0 -0.29 -0.1348 -0.4361 3083616 TimTec1_002476 CCn1c2ccccc2c3cc(/C=N/c4cccc(C#N)c4)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A13 compound treatment 201200.0 62100.0 1.02 175680.0 50100.0 0.8 1.2888 0.9924 1250862 TimTec1_002477 CC(N1C(=O)c2ccccc2C1=O)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A14 compound treatment 209240.0 70100.0 1.16 183360.0 57800.0 0.92 1.4692 0.9936 1382898 TimTec1_002478 NC(=O)c1cccc(c1)N2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A15 compound treatment 73600.0 -65500.0 -1.08 37720.0 -87900.0 -1.4 -1.7554 -0.9919 3210677 TimTec1_002479 Cc1ccc(C(=O)c2ccn(n2)C(=O)c3ccc(F)cc3)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A16 compound treatment 157880.0 18700.0 0.31 126040.0 436.0 0.01 0.2237 0.7228 3083617 TimTec1_002480 COc1cc(OC)c(/C=N/O)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A17 compound treatment 165800.0 26700.0 0.44 91240.0 -34400.0 -0.55 -0.0761 -0.1083 3210678 TimTec1_002481 Clc1cc(NC(=O)C2CC2)ccc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A18 compound treatment 93320.0 -45800.0 -0.76 81720.0 -43900.0 -0.7 -1.0294 -0.9992 3210679 TimTec1_002482 Cc1c(Cc2ccccc2)sc(/N=C/c3ccc4ccccc4c3)c1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A19 compound treatment 84360.0 -54800.0 -0.9 33160.0 -92400.0 -1.47 -1.6812 -0.9725 3083619 TimTec1_002483 CCOc1ccc(/N=C\2/C(=O)Nc3ccc(C)c(Br)c23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A20 compound treatment 8640.0 -130000.0 -2.15 4960.0 -121000.0 -1.92 -2.8829 -0.9984 1596328 TimTec1_002484 Oc1ccc(cc1)C2N(CCN2c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A21 compound treatment 52400.0 -86700.0 -1.43 48560.0 -77000.0 -1.23 -1.8807 -0.9971 3210680 TimTec1_002485 CCN(CC)c1ccc(/C=N/c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A22 compound treatment 139680.0 543.0 0.01 125080.0 -524.0 -0.01 4.0E-4 0.0351 3210681 TimTec1_002486 CCc1c(O)nc(SCC(=O)NC(C)(C)C)n(c2ccc(F)cc2)c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A23 mock treatment 180560.0 41400.0 0.68 151920.0 26300.0 0.42 0.7801 0.9725 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 A24 mock treatment 148360.0 9220.0 0.15 158040.0 32400.0 0.52 0.4732 0.8781 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B01 compound treatment 205440.0 66300.0 1.09 154880.0 29300.0 0.47 1.1039 0.9278 3210682 TimTec1_002487 CCc1n[nH]c(=O)n1Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B02 compound treatment 210600.0 71500.0 1.18 159200.0 33600.0 0.54 1.2128 0.9361 1134528 TimTec1_002488 Clc1cccc(NC(=O)NCCN2Cc3ccccc3C2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B03 compound treatment 190160.0 51000.0 0.84 133600.0 8000.0 0.13 0.6857 0.8049 1695505 TimTec1_002489 COC(=O)c1ccccc1NC(=O)c2c(C)nc3ccccn23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B04 compound treatment 203120.0 64000.0 1.06 138080.0 12500.0 0.2 0.8874 0.8257 1061354 TimTec1_002490 OC(=O)CCCN1C(=O)c2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B05 compound treatment 210560.0 71400.0 1.18 154120.0 28500.0 0.45 1.1551 0.9141 3210683 TimTec1_002491 C/C(=N\n1cnnc1)/c2ccc(cc2)n3cnnn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B06 compound treatment 198600.0 59500.0 0.98 140640.0 15000.0 0.24 0.8635 0.8546 1660739 TimTec1_002492 Clc1cccc(NC(=O)C2CN(Cc3ccccc3)C(=O)C2)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B07 compound treatment 151920.0 12800.0 0.21 88120.0 -37500.0 -0.6 -0.2732 -0.4313 1742832 TimTec1_002493 CCOC(=O)N(C)CCc1cc2OCOc2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B08 compound treatment 164280.0 25100.0 0.42 101440.0 -24200.0 -0.39 0.0211 0.0373 3083672 TimTec1_002494 Cc1ccc2nc(=S)nc(c3ccccc3)n2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B09 compound treatment 178840.0 39700.0 0.66 117680.0 -7920.0 -0.13 0.3741 0.5605 3210684 TimTec1_002495 N=C1S/C(=C\2/C(=O)NN(C2=O)c3ccccc3)/SC=C1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B10 compound treatment 169360.0 30200.0 0.5 125600.0 -3.75 0.0 0.3527 0.707 1574189 TimTec1_002496 COc1ccc(cc1)C(C#N)N2N=C(C)CC2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B11 compound treatment 162400.0 23300.0 0.38 121560.0 -4040.0 -0.06 0.226 0.5803 3083674 TimTec1_002497 O=C1NN=C(CC(N1)c2ccco2)c3cc4ccccc4oc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B12 compound treatment 182160.0 43000.0 0.71 143080.0 17500.0 0.28 0.6991 0.9165 1539134 TimTec1_002498 Sc1nc2cc(ccc2s1)C(=O)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B13 compound treatment 198440.0 59300.0 0.98 163880.0 38300.0 0.61 1.1236 0.9741 3083676 TimTec1_002499 OCc1cn(nn1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B14 compound treatment 199480.0 60300.0 1.0 141840.0 16200.0 0.26 0.8873 0.8622 1459359 TimTec1_002500 Clc1ccc(CCN2CC(CC2=O)C(=O)OCC(=O)c3ccc(Cl)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B15 compound treatment 213160.0 74000.0 1.22 141720.0 16100.0 0.26 1.0457 0.8375 1402941 TimTec1_002501 CN(C)Cc1nnnn1CCn2nnnc2CN(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B16 compound treatment 194960.0 55800.0 0.92 120360.0 -5240.0 -0.08 0.5925 0.6403 3210801 TimTec1_002502 Cc1ccc(C(=O)COC(=O)c2ccc(cc2)n3cnnn3)c(C)c1.Cc1ccc(C)c(c1)C(=O)COC(=O)c2ccc(cc2)n3cnnn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B17 compound treatment 185320.0 46200.0 0.76 113840.0 -11800.0 -0.19 0.4065 0.5178 3083678 TimTec1_002503 COC(=O)c1c(C)c(C)[nH]c(=O)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B18 compound treatment 185440.0 46300.0 0.76 98200.0 -27400.0 -0.44 0.2316 0.2631 1544714 TimTec1_002504 CCOc1ccc(c2ccccc12)S(=O)(=O)NCC3CCCO3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B19 compound treatment 191680.0 52500.0 0.87 98080.0 -27500.0 -0.44 0.3031 0.3118 1721791 TimTec1_002505 CC(C)C(C)(NC(=O)c1cccnc1Oc2ccc(Cl)cc2)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B20 compound treatment 173920.0 34800.0 0.57 105160.0 -20400.0 -0.33 0.1756 0.266 1358324 TimTec1_002506 CCOC(=O)CN(C)c1nc(cs1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B21 compound treatment 147640.0 8500.0 0.14 74960.0 -50600.0 -0.81 -0.4715 -0.5755 1160634 TimTec1_002507 O=C(NCc1nc(cs1)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B22 compound treatment 186920.0 47800.0 0.79 99840.0 -25800.0 -0.41 0.2674 0.3007 1033354 TimTec1_002508 O=C(Nc1cccc(c1)C2=NCCN2)Nc3cccc(c3)C4=NCCN4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B23 mock treatment 206320.0 67200.0 1.11 135200.0 9600.0 0.15 0.8923 0.7971 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 B24 mock treatment 203120.0 64000.0 1.06 163240.0 37600.0 0.6 1.171 0.9641 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C01 compound treatment 59280.0 -79900.0 -1.32 31840.0 -93800.0 -1.49 -1.9889 -0.998 1317591 TimTec1_002509 Brc1ccccc1OCc2ccc(o2)C(=O)Nc3ccc(I)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C02 compound treatment 25760.0 -113000.0 -1.87 8880.0 -117000.0 -1.86 -2.6389 -1.0 3210802 TimTec1_002510 Oc1ccc(Br)cc1/C=N/CCC2=CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C03 compound treatment 157760.0 18600.0 0.31 61000.0 -64600.0 -1.03 -0.5107 -0.4753 3083683 TimTec1_002511 COC(=O)c1ccc(cc1)n2nnnc2SCC(=O)NC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C04 compound treatment 78840.0 -60300.0 -1.0 47360.0 -78200.0 -1.25 -1.5856 -0.9938 3210803 TimTec1_002512 O=C(Nc1nccs1)/C=C/c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C05 compound treatment 152640.0 13500.0 0.22 137840.0 12200.0 0.2 0.2955 0.9978 1542712 TimTec1_002513 CCOc1ccc(NC(=O)CSc2nnnn2CC(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C06 compound treatment 143400.0 4260.0 0.07 135360.0 9760.0 0.16 0.1597 0.9357 3083686 TimTec1_002514 COc1cc(/C=N/O)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C07 compound treatment 123520.0 -15600.0 -0.26 37560.0 -88000.0 -1.4 -1.1746 -0.8232 1452827 TimTec1_002515 O=C(CSc1nc2scc(c3cccs3)c2c(=O)n1c4ccccc4)NCc5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C08 compound treatment 157640.0 18500.0 0.31 114000.0 -11600.0 -0.18 0.0852 0.2386 1593834 TimTec1_002516 OCc1ccccc1CN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C09 compound treatment 126960.0 -12200.0 -0.2 59000.0 -66600.0 -1.06 -0.8928 -0.8263 1361213 TimTec1_002517 COC(=O)c1cc(c(C)o1)c2cncnc2c3ccc(OC)c(C)c3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C10 compound treatment 162080.0 22900.0 0.38 95160.0 -30400.0 -0.49 -0.0753 -0.1224 3210804 TimTec1_002518 COc1ccc2ccccc2c1/C=N/c3cccc(CO)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C11 compound treatment 152760.0 13600.0 0.22 107120.0 -18500.0 -0.29 -0.0493 -0.133 1240365 TimTec1_002519 Clc1ccc(cc1)C(=O)Nc2ccccc2C(=O)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C12 compound treatment 172040.0 32900.0 0.54 125800.0 196.0 0.0 0.3863 0.7112 3083730 TimTec1_002520 Cc1cc(C)cc(/N=C/c2ccc(C#N)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C13 compound treatment 50560.0 -88600.0 -1.46 18880.0 -107000.0 -1.7 -2.2367 -0.9972 3083732 TimTec1_002521 N/C(=C\C(=O)c1ccc(Br)cc1)/C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C14 compound treatment 177360.0 38200.0 0.63 132440.0 6840.0 0.11 0.5232 0.8171 3210805 TimTec1_002522 COc1cc(/C=N/c2cc(C)ccc2C)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C15 compound treatment 185320.0 46200.0 0.76 113080.0 -12500.0 -0.2 0.3979 0.5049 3210806 TimTec1_002523 CN1CCN(CC1)C(=O)c2ccccc2NC(=O)c3ccc(F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C16 compound treatment 146920.0 7780.0 0.13 67040.0 -58600.0 -0.93 -0.5692 -0.6041 1638681 TimTec1_002524 Ic1ccc(NC(=O)c2ccccc2C(=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C17 compound treatment 18760.0 -120000.0 -1.99 7840.0 -118000.0 -1.88 -2.7323 -0.9996 3083735 TimTec1_002525 Cc1ccsc1/C=N/c2c(C)cc(C)cc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C18 compound treatment 184760.0 45600.0 0.75 94640.0 -31000.0 -0.49 0.1836 0.2039 3210807 TimTec1_002526 CC(=O)N/C(=C/c1ccccc1)/C(=O)N2CCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C19 compound treatment 45400.0 -93700.0 -1.55 29560.0 -96000.0 -1.53 -2.1766 -1.0 3210808 TimTec1_002527 CCn1c2ccccc2c3cc(/C=N/c4ccc(OC)cc4)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C20 compound treatment 120840.0 -18300.0 -0.3 65840.0 -59800.0 -0.95 -0.8871 -0.8878 3083737 TimTec1_002528 COc1cc(NC(=O)c2cccc(Br)c2)nc(OC)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C21 compound treatment 110800.0 -28300.0 -0.47 62800.0 -62800.0 -1.0 -1.0386 -0.94 3210809 TimTec1_002529 COc1cc(/C=N/c2ccc(Br)c(Cl)c2)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C22 compound treatment 150840.0 11700.0 0.19 93000.0 -32600.0 -0.52 -0.2309 -0.4164 3083739 TimTec1_002530 CC1=C(CNC(=S)N1)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C23 mock treatment 207000.0 67900.0 1.12 110840.0 -14800.0 -0.24 0.6257 0.5466 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 C24 mock treatment 185200.0 46100.0 0.76 139240.0 13600.0 0.22 0.6913 0.8742 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D01 compound treatment 160400.0 21300.0 0.35 122240.0 -3360.0 -0.05 0.2103 0.5922 3210810 TimTec1_002531 CCCc1nncn1NC(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D02 compound treatment 59840.0 -79300.0 -1.31 25120.0 -100000.0 -1.6 -2.0581 -0.995 1545647 TimTec1_002532 CCC1=NCC(=O)Nc2ccc(Cl)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D03 compound treatment 123000.0 -16100.0 -0.27 96560.0 -29000.0 -0.46 -0.5157 -0.9656 3210811 TimTec1_002533 O=C/1Nc2ccccc2\C1=N\N3C(=O)CC(=O)CC3=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D04 compound treatment 147840.0 8700.0 0.14 119920.0 -5680.0 -0.09 0.0375 0.2209 1629795 TimTec1_002534 O=C(COc1ccccc1C#N)Nc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D05 compound treatment 143880.0 4740.0 0.08 115520.0 -10100.0 -0.16 -0.0583 -0.3261 1595606 TimTec1_002535 Cc1cc(C)n(CNc2c(C)n(C)n(c3ccccc3)c2=O)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D06 compound treatment 163680.0 24500.0 0.41 134080.0 8480.0 0.14 0.382 0.8945 1277145 TimTec1_002536 CC1=NN(C(=O)Cc2ccccc2)C(C)(C)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D07 compound treatment 22360.0 -117000.0 -1.93 24000.0 -102000.0 -1.62 -2.5082 -0.9962 3210812 TimTec1_002537 CC(=O)OC1=NN(N(=C1)O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D08 compound treatment 64280.0 -74900.0 -1.24 33680.0 -91900.0 -1.47 -1.9098 -0.9964 3210813 TimTec1_002538 CCCc1ccc(OCCNC(=O)c2ccc3ccccc3n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D09 compound treatment 150160.0 11000.0 0.18 110640.0 -15000.0 -0.24 -0.04 -0.1333 1241793 TimTec1_002539 CCOC(=O)Cn1c2CCC(Cc2sc1=N)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D10 compound treatment 131760.0 -7380.0 -0.12 128840.0 3240.0 0.05 -0.0496 -0.3753 1587827 TimTec1_002540 OC(=O)CC1(CC(=O)NCc2ccc3OCOc3c2)CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D11 compound treatment 136280.0 -2860.0 -0.05 115640.0 -9960.0 -0.16 -0.1456 -0.8792 3083745 TimTec1_002541 Clc1ccc(CNC(=C(C#N)C#N)Nc2ccccc2)cn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D12 compound treatment 151000.0 11900.0 0.2 134000.0 8400.0 0.13 0.2331 0.9828 1378435 TimTec1_002542 CCCC(O)(CCC)C(=O)NN1CCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D13 compound treatment 63360.0 -75800.0 -1.25 57160.0 -68400.0 -1.09 -1.6559 -0.9977 1537190 TimTec1_002543 CCCC(=O)n1c(=O)oc2cc(Br)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D14 compound treatment 141240.0 2100.0 0.03 113720.0 -11900.0 -0.19 -0.1094 -0.5681 3083789 TimTec1_002544 COc1ccc(C#N)c(c1)S(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D15 compound treatment 152720.0 13600.0 0.22 111960.0 -13600.0 -0.22 0.0048 0.0153 3241 TimTec1_002545 CN1CCCN=C1/C=C/c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D16 compound treatment 131800.0 -7340.0 -0.12 95480.0 -30100.0 -0.48 -0.4251 -0.8586 3083792 TimTec1_002546 CNc1nc(Nc2ccc(OC(F)(F)F)cc2)nc(OCC(F)(F)F)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D17 compound treatment 29880.0 -109000.0 -1.8 16200.0 -109000.0 -1.74 -2.5083 -0.9999 1551509 TimTec1_002547 C(N1CCOCC1)c2ccc(cc2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D18 compound treatment 149440.0 10300.0 0.17 104520.0 -21100.0 -0.34 -0.1174 -0.3116 3210815 TimTec1_002548 CCC1(C)OC(=O)N2CCc3ccccc3C21C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D19 compound treatment 169600.0 30500.0 0.5 110400.0 -15200.0 -0.24 0.1842 0.33 1026666 TimTec1_002549 Clc1ccccc1NC(=O)Nc2ccccc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D20 compound treatment 164640.0 25500.0 0.42 87080.0 -38500.0 -0.61 -0.1365 -0.1833 3083794 TimTec1_002550 Oc1cc(n[nH]1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D21 compound treatment 137760.0 -1380.0 -0.02 108400.0 -17200.0 -0.27 -0.21 -0.7631 1273445 TimTec1_002551 CC(=O)Nc1cc2OCCOc2cc1C(=O)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D22 compound treatment 196560.0 57400.0 0.95 107680.0 -17900.0 -0.29 0.4683 0.473 1411171 TimTec1_002552 OCCN1CCN(CC1)S(=O)(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D23 mock treatment 188880.0 49700.0 0.82 108560.0 -17000.0 -0.27 0.3885 0.4492 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 D24 mock treatment 176600.0 37500.0 0.62 120360.0 -5240.0 -0.08 0.3782 0.606 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E01 compound treatment 146480.0 7340.0 0.12 113280.0 -12300.0 -0.2 -0.0532 -0.2304 1153857 TimTec1_002553 COc1ccc(NC(=S)N2CCN(C)CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E02 compound treatment 104880.0 -34300.0 -0.57 56800.0 -68800.0 -1.1 -1.1753 -0.9525 1699449 TimTec1_002554 S=C(Nc1sc2CCCc2c1C#N)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E03 compound treatment 141480.0 2340.0 0.04 76400.0 -49200.0 -0.78 -0.5272 -0.6714 1502764 TimTec1_002555 Cc1cc(C)n(n1)C(Nc2cc(C)ccn2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E04 compound treatment 11000.0 -128000.0 -2.12 8400.0 -117000.0 -1.87 -2.8166 -0.9981 1627110 TimTec1_002556 OCc1ccccc1CNc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E05 compound treatment 140440.0 1300.0 0.02 122120.0 -3480.0 -0.06 -0.0241 -0.4041 1382760 TimTec1_002557 CCC(=O)Nc1nc(NC(=O)CC)c2ncn(C(=O)CC)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E06 compound treatment 139640.0 503.0 0.01 116520.0 -9080.0 -0.14 -0.0965 -0.6655 1126108 TimTec1_002558 COc1ccc(CCNc2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E07 compound treatment 128760.0 -10400.0 -0.17 100600.0 -25000.0 -0.4 -0.4029 -0.9289 3083800 TimTec1_002559 COc1ccc(cc1)C2=C3NN=C(N)N3NN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E08 compound treatment 142880.0 3740.0 0.06 100560.0 -25000.0 -0.4 -0.2386 -0.5906 1594522 TimTec1_002560 CNCc1cc2ccccc2s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E09 compound treatment 134320.0 -4820.0 -0.08 100800.0 -24800.0 -0.4 -0.3358 -0.8327 3210930 TimTec1_002561 COc1ccc(c(O)c1)c2ncnc(c2c3cscn3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E10 compound treatment 78880.0 -60300.0 -0.99 61720.0 -63900.0 -1.02 -1.4233 -0.9999 3083802 TimTec1_002562 CCOC(=O)c1ccc(/N=C/c2ccc3ccccc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E11 compound treatment 134600.0 -4540.0 -0.07 106320.0 -19300.0 -0.31 -0.2703 -0.8544 1258628 TimTec1_002563 NS(=O)(=O)c1ccc(CCNC(=O)C(Sc2ccccc2)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E12 compound treatment 135680.0 -3460.0 -0.06 129400.0 3800.0 0.06 0.0024 0.0292 3083804 TimTec1_002564 CCN(CC)c1ccc(/C=N/c2cc(C)cc(C)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E13 compound treatment 27600.0 -112000.0 -1.84 27840.0 -97800.0 -1.56 -2.4037 -0.9966 3210931 TimTec1_002565 Cc1ccc(O)c(c1)c2cc(no2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E14 compound treatment 136880.0 -2260.0 -0.04 32400.0 -93200.0 -1.49 -1.0768 -0.7246 1565284 TimTec1_002566 CN(C)c1ccc(cc1)C2N(Cc3ccccc3)CCN2Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E15 compound treatment 67480.0 -71700.0 -1.18 60560.0 -65000.0 -1.04 -1.5695 -0.9978 1532411 TimTec1_002567 O=C(Nc1ccccc1)Nc2ccc(cc2)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E16 compound treatment 108400.0 -30700.0 -0.51 92840.0 -32800.0 -0.52 -0.728 -0.9999 1209164 TimTec1_002568 N#Cc1ccc(cc1)C2N(CCN2c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E17 compound treatment 142640.0 3500.0 0.06 122600.0 -3000.0 -0.05 0.007 0.0936 1709264 TimTec1_002569 OC(c1cccs1)c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E18 compound treatment 78720.0 -60400.0 -1.0 60960.0 -64600.0 -1.03 -1.4338 -0.9999 3210932 TimTec1_002570 CCn1c2ccccc2c3cc(/C=N/c4ccc(C)cc4O)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E19 compound treatment 154920.0 15800.0 0.26 132720.0 7120.0 0.11 0.2644 0.9306 3083808 TimTec1_002571 FC(F)(F)Oc1ccc(/N=C/c2ccc[nH]2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E20 compound treatment 142840.0 3700.0 0.06 126720.0 1120.0 0.02 0.0558 0.8766 1012470 TimTec1_002572 COc1ccc(CNC2CCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E21 compound treatment 119840.0 -19300.0 -0.32 92800.0 -32800.0 -0.52 -0.595 -0.9718 3210933 TimTec1_002573 COC(=O)c1ccc(/N=C/c2ccc(Br)s2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E22 compound treatment 150120.0 11000.0 0.18 101440.0 -24200.0 -0.39 -0.1441 -0.3386 1473837 TimTec1_002574 O=C(NCc1ccco1)C2CCCN2S(=O)(=O)c3ccc4ccccc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E23 mock treatment 148000.0 8860.0 0.15 122480.0 -3120.0 -0.05 0.0682 0.4416 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 E24 mock treatment 151720.0 12600.0 0.21 111880.0 -13700.0 -0.22 -0.0078 -0.0259 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F01 compound treatment 161880.0 22700.0 0.38 109440.0 -16200.0 -0.26 0.0833 0.1829 1161969 TimTec1_002575 CN(C)c1ccc(cc1)C2ON2[C@H]3CC[C@H](O)CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F02 compound treatment 159760.0 20600.0 0.34 112080.0 -13500.0 -0.22 0.0883 0.2191 1195693 TimTec1_002576 COc1ccc(cc1OC)C2OC(=O)C(=C(O)C2(C)C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F03 compound treatment 80720.0 -58400.0 -0.96 67160.0 -58400.0 -0.93 -1.3405 -0.9999 3210934 TimTec1_002577 CN(C)c1ccc(/C=C(/NC(=O)c2ccccc2)\C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F04 compound treatment 134040.0 -5100.0 -0.08 123360.0 -2240.0 -0.04 -0.0848 -0.9274 1326441 TimTec1_002578 Nc1nonc1OCc2ccc3OCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F05 compound treatment 133440.0 -5700.0 -0.09 113280.0 -12300.0 -0.2 -0.2054 -0.9431 3210935 TimTec1_002579 Clc1ccc(/C=N/N2C(=O)CNC2=O)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F06 compound treatment 145080.0 5940.0 0.1 108800.0 -16800.0 -0.27 -0.12 -0.4208 3083845 TimTec1_002580 CCOC(=O)c1cc(C)[nH]c(=S)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F07 compound treatment 138760.0 -378.0 -0.01 118280.0 -7320.0 -0.12 -0.0869 -0.7438 3210936 TimTec1_002581 CCOC(=O)C1C(C)NC(=O)N=C1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F08 compound treatment 141960.0 2820.0 0.05 126280.0 676.0 0.01 0.0406 0.8483 1507322 TimTec1_002582 COc1ccc(cc1OC)C(=O)CSc2nc(N)cc(=O)[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F09 compound treatment 139560.0 423.0 0.01 123240.0 -2360.0 -0.04 -0.0217 -0.5666 1564107 TimTec1_002583 Oc1ccccc1SCC(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F10 compound treatment 142480.0 3340.0 0.06 123800.0 -1800.0 -0.03 0.0187 0.3003 1190430 TimTec1_002584 OC(=O)c1ccccc1c2nnn[nH]2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F11 compound treatment 135360.0 -3780.0 -0.06 129360.0 3760.0 0.06 -0.0018 -0.0203 3210937 TimTec1_002585 Cc1ccnc(NS(=O)(=O)c2ccc(/N=C/3\SCC(=O)N3CC=C)cc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F12 compound treatment 87480.0 -51700.0 -0.85 72680.0 -52900.0 -0.84 -1.1994 -1.0 3210938 TimTec1_002586 COC(=O)C1=CN(Cc2ccc(Cl)cc2)C=C(C1c3cccs3)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F13 compound treatment 93880.0 -45300.0 -0.75 90000.0 -35600.0 -0.57 -0.9295 -0.9908 1386655 TimTec1_002587 COc1ccc(OC)c(c1)C(=O)COc2ccccc2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F14 compound treatment 156800.0 17700.0 0.29 132000.0 6400.0 0.1 0.2783 0.9009 1502288 TimTec1_002588 Nc1nc(=O)n(CCC#N)cc1F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F15 compound treatment 104520.0 -34600.0 -0.57 78720.0 -46900.0 -0.75 -0.9325 -0.9912 1508658 TimTec1_002589 CSC1=C(C#N)C2(CCCCC2)C3=C(CCC3)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F16 compound treatment 148080.0 8940.0 0.15 122600.0 -3000.0 -0.05 0.0705 0.4545 1232692 TimTec1_002590 Cc1cccc(C)c1NC(=O)C(NC(=O)c2ccc(cc2)n3cnnn3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F17 compound treatment 151000.0 11900.0 0.2 134080.0 8480.0 0.14 0.234 0.9836 3083851 TimTec1_002591 COc1ccc(Cl)cc1C(=O)NN2C(=CC(C)(C)NC2=S)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F18 compound treatment 135480.0 -3660.0 -0.06 117000.0 -8600.0 -0.14 -0.1397 -0.9321 3210939 TimTec1_002592 FC(F)(F)C1(N=C(OC(=N1)N2CCOCC2)N3CCOCC3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F19 compound treatment 141160.0 2020.0 0.03 117840.0 -7760.0 -0.12 -0.0639 -0.4985 3083853 TimTec1_002593 NC1=NC(=O)C(CC(=O)O)CS1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F20 compound treatment 123600.0 -15500.0 -0.26 94720.0 -30900.0 -0.49 -0.5294 -0.9538 1554458 TimTec1_002594 CCOC(=O)C1(CCN(CCC(=O)Nc2ccc(cc2)C(=O)OC)CC1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F21 compound treatment 125840.0 -13300.0 -0.22 115600.0 -10000.0 -0.16 -0.268 -0.9877 1231612 TimTec1_002595 COc1ccc(cc1)C2C(C)C3(O)CC(C#N)(C(=O)N3)C2(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F22 compound treatment 103080.0 -36100.0 -0.6 94560.0 -31000.0 -0.49 -0.7707 -0.9958 1368021 TimTec1_002596 CC(=O)N(CCOc1ccccc1)CCOc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F23 mock treatment 140480.0 1340.0 0.02 128000.0 2400.0 0.04 0.0427 0.9665 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 F24 mock treatment 138440.0 -698.0 -0.01 111120.0 -14500.0 -0.23 -0.1714 -0.7415 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G01 compound treatment 145760.0 6620.0 0.11 115840.0 -9760.0 -0.16 -0.0327 -0.1721 1248844 TimTec1_002597 Cc1ccc(o1)C(=O)NCC2CCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G02 compound treatment 100440.0 -38700.0 -0.64 74960.0 -50600.0 -0.81 -1.0225 -0.9933 3210940 TimTec1_002598 S=C(Nc1ccccc1)Nc2cccc(C#N)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G03 compound treatment 127800.0 -11300.0 -0.19 69040.0 -56600.0 -0.9 -0.7698 -0.8361 1385961 TimTec1_002599 Cc1ccc(cc1C)C(=O)COC(=O)c2ccc(cc2)c3nnc(o3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G04 compound treatment 70640.0 -68500.0 -1.13 53280.0 -72300.0 -1.15 -1.6146 -1.0 1301988 TimTec1_002600 Brc1c(OCC(=O)NCc2ccccc2)ccc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G05 compound treatment 173320.0 34200.0 0.56 106960.0 -18600.0 -0.3 0.1889 0.2962 3210941 TimTec1_002601 O=C1CNC(=O)N1/N=C/2\C(=O)Nc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G06 compound treatment 100800.0 -38300.0 -0.63 89000.0 -36600.0 -0.58 -0.86 -0.9992 3083899 TimTec1_002602 COc1ccc(CCNCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G07 compound treatment 122200.0 -16900.0 -0.28 97520.0 -28100.0 -0.45 -0.5142 -0.9743 3083901 TimTec1_002603 Cc1c(C#N)c(=O)n(nc1C(=O)O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G08 compound treatment 137280.0 -1860.0 -0.03 105600.0 -20000.0 -0.32 -0.2471 -0.7716 3210942 TimTec1_002604 Cn1ccnc1C(O)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G09 compound treatment 132280.0 -6860.0 -0.11 95800.0 -29800.0 -0.48 -0.4159 -0.8518 3210943 TimTec1_002605 CCCN1C(=O)/C(=C\2/C(=O)N(CC=C)c3ccccc23)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G10 compound treatment 137720.0 -1420.0 -0.02 117200.0 -8400.0 -0.13 -0.1113 -0.8182 3083904 TimTec1_002606 NC(=O)c1cccc(/N=C/c2ccc3ccccc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G11 compound treatment 127600.0 -11500.0 -0.19 120160.0 -5440.0 -0.09 -0.196 -0.9366 3210944 TimTec1_002607 CCOc1ccccc1/C=N/c2ccc(cc2)S(=O)(=O)N3CCc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G12 compound treatment 176080.0 36900.0 0.61 120600.0 -5000.0 -0.08 0.3748 0.6094 3083906 TimTec1_002608 Cc1ccc(C)c(/N=C/c2ccc(C#N)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G13 compound treatment 44440.0 -94700.0 -1.56 49480.0 -76100.0 -1.21 -1.9633 -0.9922 3210945 TimTec1_002609 Oc1ccccc1c2cc(n(n2)c3ccccc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G14 compound treatment 127360.0 -11800.0 -0.19 119520.0 -6080.0 -0.1 -0.206 -0.9484 3083907 TimTec1_002610 Oc1c(Cl)cc(Cl)cc1/C=N/c2sc3CCCc3c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G15 compound treatment 132080.0 -7060.0 -0.12 124840.0 -764.0 -0.01 -0.091 -0.7768 1229191 TimTec1_002611 Nc1ccc(cc1)C(=O)N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G16 compound treatment 120960.0 -18200.0 -0.3 109560.0 -16000.0 -0.26 -0.393 -0.9968 1298485 TimTec1_002612 C=CCC(CC=C)(NC(=O)c1ccccc1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G17 compound treatment 77080.0 -62100.0 -1.02 75360.0 -50200.0 -0.8 -1.2906 -0.9926 3210946 TimTec1_002613 CSc1ccc(/C=N/c2ccc(Nc3ccccc3)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G18 compound treatment 42400.0 -96700.0 -1.6 46400.0 -79200.0 -1.26 -2.0218 -0.9932 3210947 TimTec1_002614 Cc1[nH]c2ccccc2c1/C=N/c3ccc(Cl)cc3C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G19 compound treatment 136880.0 -2260.0 -0.04 122680.0 -2920.0 -0.05 -0.0593 -0.9939 3083909 TimTec1_002615 COC(=O)CSc1nc(cc(c1C#N)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G20 compound treatment 94000.0 -45100.0 -0.75 84880.0 -40700.0 -0.65 -0.9858 -0.9976 1173404 TimTec1_002616 COc1ccc2ccccc2c1C(O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G21 compound treatment 19120.0 -120000.0 -1.98 10480.0 -115000.0 -1.83 -2.6984 -0.9993 3083910 TimTec1_002617 CCN(CC)c1ccc(/N=C/c2cccs2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G22 compound treatment 142160.0 3020.0 0.05 78800.0 -46800.0 -0.75 -0.4922 -0.6583 3210948 TimTec1_002618 CN1C(=O)/C(=C\c2c(O)c3ccccc3n(C)c2=O)/C(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G23 mock treatment 144000.0 4860.0 0.08 118600.0 -7000.0 -0.11 -0.0222 -0.1613 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 G24 mock treatment 130160.0 -8980.0 -0.15 118800.0 -6800.0 -0.11 -0.1815 -0.9882 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H01 compound treatment 122640.0 -16500.0 -0.27 105960.0 -19600.0 -0.31 -0.414 -0.9976 1619414 TimTec1_002619 Cc1cc(no1)c2c(O)c3ccccc3n(C)c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H02 compound treatment 129280.0 -9860.0 -0.16 111960.0 -13600.0 -0.22 -0.2688 -0.9898 1650607 TimTec1_002620 CC1C(OC(=O)C2(CCCCC2)C1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H03 compound treatment 122080.0 -17100.0 -0.28 99560.0 -26000.0 -0.42 -0.4926 -0.9821 1490854 TimTec1_002621 O=COCC1OC(OC=O)C(Nc2ccccc2)C(OC=O)C1OC=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H04 compound treatment 69440.0 -69700.0 -1.15 63400.0 -62200.0 -0.99 -1.5146 -0.9973 1609235 TimTec1_002622 Fc1ccc(CSc2nc3cccnc3[nH]2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H05 compound treatment 17320.0 -122000.0 -2.01 10480.0 -115000.0 -1.83 -2.7194 -0.999 3211069 TimTec1_002623 C/C(=N\N1C(=O)CC(=O)NC1=S)/c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H06 compound treatment 141640.0 2500.0 0.04 112760.0 -12800.0 -0.2 -0.1155 -0.5533 3083914 TimTec1_002624 CC1SC(NC1=O)c2ccc(F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H07 compound treatment 128920.0 -10200.0 -0.17 126640.0 1040.0 0.02 -0.1076 -0.6348 1308303 TimTec1_002625 CCOC(=O)c1cccc(c1)C(=O)NC2=CC(=O)CC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H08 compound treatment 133880.0 -5260.0 -0.09 121160.0 -4440.0 -0.07 -0.1114 -0.9949 3083916 TimTec1_002626 COc1ccc(cc1)C(=O)c2nocc2C(=O)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H09 compound treatment 60880.0 -78300.0 -1.29 59120.0 -66500.0 -1.06 -1.6627 -0.9952 1428534 TimTec1_002627 O=c1oc2ccccc2cc1C3=NC(=S)NC(C3)c4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H10 compound treatment 128120.0 -11000.0 -0.18 113920.0 -11700.0 -0.19 -0.2603 -0.9999 1170391 TimTec1_002628 NC(=O)CN1C(=O)c2cccc3cccc1c23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H11 compound treatment 130880.0 -8260.0 -0.14 111800.0 -13800.0 -0.22 -0.252 -0.9735 3211070 TimTec1_002629 S=c1nc(/N=C/c2ccco2)cc(/N=C/c3ccco3)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H12 compound treatment 139920.0 783.0 0.01 129640.0 4040.0 0.06 0.0546 0.8325 1704493 TimTec1_002630 Cc1cc2OC(=C(C#N)C3(C(=O)N(CC(=O)O)c4ccccc43)c2c(=O)o1)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H13 compound treatment 136840.0 -2300.0 -0.04 122200.0 -3400.0 -0.05 -0.0652 -0.9847 1554929 TimTec1_002631 O=C(Oc1cccnc1)c2cc3ccccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H14 compound treatment 148480.0 9340.0 0.15 136120.0 10500.0 0.17 0.2276 0.9991 1212825 TimTec1_002632 Cc1[nH]c2ccccc2c1CCN3C(=O)CCC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H15 compound treatment 15040.0 -124000.0 -2.05 15480.0 -110000.0 -1.76 -2.6896 -0.997 1243289 TimTec1_002633 COC(=O)C1=C(C)N(C(=O)C1)c2ccc(cc2)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H16 compound treatment 135680.0 -3460.0 -0.06 126840.0 1240.0 0.02 -0.0264 -0.4376 1495691 TimTec1_002634 CC(O)(C#CCN1CCCCC1)C2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H17 compound treatment 144240.0 5100.0 0.08 131040.0 5440.0 0.09 0.1208 0.9999 1405861 TimTec1_002635 CCN(CC)C(=O)CSc1nc2CCCCc2cc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H18 compound treatment 100240.0 -38900.0 -0.64 102200.0 -23400.0 -0.37 -0.7178 -0.9666 3083985 TimTec1_002636 CCc1c(C)nc(N)nc1S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H19 compound treatment 123120.0 -16000.0 -0.26 112200.0 -13400.0 -0.21 -0.338 -0.9944 1285150 TimTec1_002637 CC1(O)NC(=O)C2(C#N)C(C#N)(C#N)C21c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H20 compound treatment 128280.0 -10900.0 -0.18 133960.0 8360.0 0.13 -0.0326 -0.1458 1677097 TimTec1_002638 Cc1nc(C(=O)N)c(N)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H21 compound treatment 140080.0 943.0 0.02 115720.0 -9880.0 -0.16 -0.1004 -0.6342 1163471 TimTec1_002639 COC(=O)c1ccc(NC(=O)CSc2nccn2C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H22 compound treatment 127680.0 -11500.0 -0.19 116080.0 -9520.0 -0.15 -0.2411 -0.9941 3083989 TimTec1_002640 Cc1cc(C)n(CNc2nccs2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H23 mock treatment 149080.0 9940.0 0.16 118680.0 -6920.0 -0.11 0.038 0.1922 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 H24 mock treatment 127280.0 -11900.0 -0.2 116400.0 -9200.0 -0.15 -0.2421 -0.9899 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I01 compound treatment 93680.0 -45500.0 -0.75 97960.0 -27600.0 -0.44 -0.8421 -0.9678 1611631 TimTec1_002641 O=C(Nc1ccccc1)Nc2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I02 compound treatment 64720.0 -74400.0 -1.23 55320.0 -70300.0 -1.12 -1.6607 -0.9989 1685279 TimTec1_002642 COc1ccc(cc1I)C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I03 compound treatment 124400.0 -14700.0 -0.24 83120.0 -42500.0 -0.68 -0.6508 -0.9045 1725903 TimTec1_002643 CCOC(=O)C(C)Oc1ccc2oc(=O)cc(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I04 compound treatment 167880.0 28700.0 0.47 93760.0 -31800.0 -0.51 -0.0234 -0.0337 1725678 TimTec1_002644 Cc1ccc(NC(=O)COc2ccc3ccccc3c2Br)cc1F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I05 compound treatment 135320.0 -3820.0 -0.06 115880.0 -9720.0 -0.15 -0.1541 -0.9214 3083992 TimTec1_002645 CN(C)c1ccc(/C=N/N2C(=O)CNC2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I06 compound treatment 11200.0 -128000.0 -2.11 9400.0 -116000.0 -1.85 -2.803 -0.9979 3211071 TimTec1_002646 CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1OC(=O)C(O)C(O)C(=O)O[C@H]2C[C@H](C)CC[C@H]2C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I07 compound treatment 123840.0 -15300.0 -0.25 109000.0 -16600.0 -0.26 -0.3657 -0.9997 1159008 TimTec1_002647 O=C(CSc1ncnc2[nH]cnc12)NCCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I08 compound treatment 114560.0 -24600.0 -0.41 85080.0 -40500.0 -0.65 -0.7436 -0.9749 3211072 TimTec1_002648 Cc1ccc(/N=C/c2ccc(Br)s2)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I09 compound treatment 96600.0 -42500.0 -0.7 75960.0 -49600.0 -0.79 -1.056 -0.9982 1275751 TimTec1_002649 Cc1cccc(c1)N(CC(=O)Nc2ccc3c(c2)oc4ccccc43)S(=O)(=O)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I10 compound treatment 46880.0 -92300.0 -1.52 40920.0 -84700.0 -1.35 -2.0313 -0.9982 3083996 TimTec1_002650 COc1ccc(/N=C/c2ccc3ccccc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I11 compound treatment 53600.0 -85500.0 -1.41 53840.0 -71800.0 -1.14 -1.8072 -0.9945 3211073 TimTec1_002651 CC(=O)Nc1ccc(cc1)c2csc(Nc3ccccc3C)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I12 compound treatment 140720.0 1580.0 0.03 129040.0 3440.0 0.05 0.0572 0.9426 3083998 TimTec1_002652 Cc1cccc(/C=N/c2cccc(O)c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I13 compound treatment 118840.0 -20300.0 -0.34 107080.0 -18500.0 -0.3 -0.4457 -0.998 3083999 TimTec1_002653 O=c1n(OCc2ccccc2)c(SCc3ccccc3)nc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I14 compound treatment 125400.0 -13700.0 -0.23 123160.0 -2440.0 -0.04 -0.1879 -0.8166 3211074 TimTec1_002654 Cc1ccc(/C=N/c2ccc(Oc3ccccc3)cc2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I15 compound treatment 62160.0 -77000.0 -1.27 65320.0 -60300.0 -0.96 -1.5779 -0.9905 3211075 TimTec1_002655 O=C(Nc1ccccc1)Nc2ccc(cc2)C(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I16 compound treatment 115000.0 -24100.0 -0.4 109600.0 -16000.0 -0.26 -0.4621 -0.9768 1270363 TimTec1_002656 Cc1ccc(cc1)S(=O)(=O)NC(CC=C)(CC=C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I17 compound treatment 109640.0 -29500.0 -0.49 120520.0 -5080.0 -0.08 -0.4016 -0.8136 3211076 TimTec1_002657 N#Cc1ccc(/C=N/c2cccc3c(\N=C\c4ccc(C#N)cc4)cccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I18 compound treatment 89960.0 -49200.0 -0.81 93880.0 -31700.0 -0.51 -0.9316 -0.974 3084003 TimTec1_002658 NC(=O)c1ccccc1/N=C/c2ccc(O)c(O)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I19 compound treatment 57800.0 -81300.0 -1.34 85560.0 -40000.0 -0.64 -1.4007 -0.9422 3211077 TimTec1_002659 Oc1ccc(Br)cc1/C=N/Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I20 compound treatment 120640.0 -18500.0 -0.31 113560.0 -12000.0 -0.19 -0.3516 -0.975 1542526 TimTec1_002660 COc1cc(CNc2ccccc2)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I21 compound treatment 124920.0 -14200.0 -0.23 110960.0 -14600.0 -0.23 -0.331 -1.0 3211078 TimTec1_002661 N#Cc1cccc(/N=C/c2ccc3OCOc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I22 compound treatment 114800.0 -24300.0 -0.4 107520.0 -18100.0 -0.29 -0.4879 -0.9867 1646643 TimTec1_002662 CCn1c(=O)c(C(C)Nc2ccco2)c(O)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I23 mock treatment 126280.0 -12900.0 -0.21 134280.0 8680.0 0.14 -0.0523 -0.2064 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 I24 mock treatment 108080.0 -31100.0 -0.51 116560.0 -9040.0 -0.14 -0.4644 -0.8721 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J01 compound treatment 104640.0 -34500.0 -0.57 108720.0 -16900.0 -0.27 -0.593 -0.9414 1132674 TimTec1_002663 CCC1=CC(=NC(C)CN1)c2c(O)c3ccccc3n(C)c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J02 compound treatment 152720.0 13600.0 0.22 132800.0 7200.0 0.11 0.2396 0.9516 3084072 TimTec1_002664 OC(=O)c1ccc2nsnc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J03 compound treatment 132680.0 -6460.0 -0.11 113920.0 -11700.0 -0.19 -0.2071 -0.965 1532331 TimTec1_002665 Fc1ccc(cc1)N2C(=S)N=C(CC23C(=O)Nc4ccccc43)c5ccc(F)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J04 compound treatment 104000.0 -35100.0 -0.58 100320.0 -25300.0 -0.4 -0.6951 -0.9842 3084075 TimTec1_002666 FC(F)(F)c1ccc2n(Cc3ccccc3)c(=O)c(=O)[nH]c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J05 compound treatment 134040.0 -5100.0 -0.08 121680.0 -3920.0 -0.06 -0.1037 -0.9893 1654151 TimTec1_002667 O=c1ccn(CN2CCCCC2)c(=O)n1CN3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J06 compound treatment 133160.0 -5980.0 -0.1 113400.0 -12200.0 -0.19 -0.2073 -0.9505 1571522 TimTec1_002668 CN1NC2(CCCCC2)N(C1=S)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J07 compound treatment 127560.0 -11600.0 -0.19 118840.0 -6760.0 -0.11 -0.2114 -0.9633 3211079 TimTec1_002669 Oc1ccccc1/C=N/c2cc(ccc2O)S(=O)(=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J08 compound treatment 129000.0 -10100.0 -0.17 116920.0 -8680.0 -0.14 -0.2162 -0.9956 1488051 TimTec1_002670 CC1CN(CCc2ccccc2)CCC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J09 compound treatment 136040.0 -3100.0 -0.05 122000.0 -3600.0 -0.06 -0.0768 -0.9983 3211080 TimTec1_002671 C/C(=N\Cc1ccccn1)/c2c(O)c3ccccc3n(c4ccccc4)c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J10 compound treatment 132000.0 -7140.0 -0.12 123360.0 -2240.0 -0.04 -0.1086 -0.882 3084079 TimTec1_002672 OCCNC(=O)C1=NN=CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J11 compound treatment 139320.0 183.0 0.0 132720.0 7120.0 0.11 0.0823 0.7256 1667994 TimTec1_002673 CC1=NN(C(=O)c2ccco2)C(O)(C1)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J12 compound treatment 136280.0 -2860.0 -0.05 125080.0 -524.0 -0.01 -0.0393 -0.8195 3211081 TimTec1_002674 OC(=O)CCCNC1=NC2(CCCC2)Cc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J13 compound treatment 136600.0 -2540.0 -0.04 126200.0 596.0 0.01 -0.0229 -0.5331 3209107 TimTec1_002675 NC(CCCNC(=N)N)C(=O)O.OC(=O)CCCC[C@H]1SC[C@H]2NC(=O)N[C@@H]12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J14 compound treatment 146040.0 6900.0 0.11 124800.0 -804.0 -0.01 0.0715 0.6237 1608879 TimTec1_002676 NN(C(=O)C1CCCCC1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J15 compound treatment 134360.0 -4780.0 -0.08 125360.0 -244.0 0.0 -0.0585 -0.741 1250350 TimTec1_002677 COc1cc(NC(=O)C)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J16 compound treatment 133440.0 -5700.0 -0.09 132000.0 6400.0 0.1 0.0056 0.0403 1447389 TimTec1_002678 Cn1cnc2n(Cc3ccccc3)c(=O)[nH]c(=S)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J17 compound treatment 125680.0 -13500.0 -0.22 115760.0 -9840.0 -0.16 -0.268 -0.9855 1466505 TimTec1_002679 COCc1cc(O)n2c3ccccc3nc2c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J18 compound treatment 115440.0 -23700.0 -0.39 112160.0 -13400.0 -0.21 -0.4281 -0.9599 1156263 TimTec1_002680 COC(=O)CC1(O)N(C(=CC1=O)c2ccc(C)cc2)c3ccccc3OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J19 compound treatment 118920.0 -20200.0 -0.33 122000.0 -3600.0 -0.06 -0.2766 -0.8168 1548500 TimTec1_002681 CC1(C)CCCC(C)(C)N1OC(=O)c2ccc(N)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J20 compound treatment 17200.0 -122000.0 -2.01 28600.0 -97000.0 -1.55 -2.5166 -0.9915 3084081 TimTec1_002682 OC1(NN=C2C=Cc3ccccc3N21)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J21 compound treatment 107480.0 -31700.0 -0.52 101000.0 -24600.0 -0.39 -0.6468 -0.99 1276203 TimTec1_002683 CNC(C)c1ccc2OCCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J22 compound treatment 120000.0 -19100.0 -0.32 103960.0 -21600.0 -0.34 -0.4673 -0.999 3084083 TimTec1_002684 C(N1CCNCC1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J23 mock treatment 129640.0 -9500.0 -0.16 118560.0 -7040.0 -0.11 -0.1902 -0.9866 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 J24 mock treatment 133200.0 -5940.0 -0.1 126240.0 636.0 0.01 -0.0621 -0.6306 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K01 compound treatment 100400.0 -38700.0 -0.64 114920.0 -10700.0 -0.17 -0.5726 -0.8653 3209108 TimTec1_002685 COc1ccc(cc1)C(=O)CSc2nc3cc(C)ccc3cc2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K02 compound treatment 103920.0 -35200.0 -0.58 96920.0 -28700.0 -0.46 -0.7343 -0.9929 3084085 TimTec1_002686 CCOc1ccc(/C=N/c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K03 compound treatment 115480.0 -23700.0 -0.39 98640.0 -27000.0 -0.43 -0.58 -0.9989 1247383 TimTec1_002687 O=C(CSc1nc2cccnc2[nH]1)NC3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K04 compound treatment 52040.0 -87100.0 -1.44 43040.0 -82600.0 -1.32 -1.9471 -0.999 3084087 TimTec1_002688 COc1cccc(/N=C/c2ccc(O)cc2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K05 compound treatment 85240.0 -53900.0 -0.89 94840.0 -30800.0 -0.49 -0.9758 -0.9606 3209109 TimTec1_002689 O=C1CNC(=O)N1/N=C/c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K06 compound treatment 146640.0 7500.0 0.12 115520.0 -10100.0 -0.16 -0.0261 -0.1285 1409322 TimTec1_002690 OCc1ccccc1CNCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K07 compound treatment 20720.0 -118000.0 -1.95 26800.0 -98800.0 -1.57 -2.4958 -0.9943 3209110 TimTec1_002691 CCOC(=O)Cc1c(C)[nH]c2c(c(C)nn2c1=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K08 compound treatment 92640.0 -46500.0 -0.77 78440.0 -47200.0 -0.75 -1.0743 -0.9999 3084090 TimTec1_002692 Cc1ccc(/N=C/c2c[nH]c3ccccc23)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K09 compound treatment 14000.0 -125000.0 -2.07 11360.0 -114000.0 -1.82 -2.7482 -0.998 1411633 TimTec1_002693 CC(NC(=O)c1cc(oc1C)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K10 compound treatment 60440.0 -78700.0 -1.3 52840.0 -72800.0 -1.16 -1.7387 -0.9984 3084091 TimTec1_002694 NC(=O)c1ccccc1/N=C/c2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K11 compound treatment 134040.0 -5100.0 -0.08 121240.0 -4360.0 -0.07 -0.1087 -0.9955 3209111 TimTec1_002695 Cc1ccc(cc1)S(=O)(=O)NC(=O)Nc2cccc(c2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K12 compound treatment 106200.0 -32900.0 -0.54 112680.0 -12900.0 -0.21 -0.5301 -0.9118 3084157 TimTec1_002696 Cc1cc(C)cc(/N=C/c2cccc(OCc3ccccc3)c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K13 compound treatment 132160.0 -6980.0 -0.12 123440.0 -2160.0 -0.03 -0.1058 -0.8802 3084159 TimTec1_002697 COC(=O)CNC(=O)c1cc[nH]n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K14 compound treatment 128360.0 -10800.0 -0.18 128720.0 3120.0 0.05 -0.0907 -0.4909 1444507 TimTec1_002698 Cc1ccc(s1)C2N(CCN2c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K15 compound treatment 122400.0 -16700.0 -0.28 128240.0 2640.0 0.04 -0.1657 -0.5928 3084162 TimTec1_002699 FC(F)(F)Oc1ccc(/N=C/c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K16 compound treatment 98480.0 -40700.0 -0.67 101840.0 -23800.0 -0.38 -0.7424 -0.9633 1914768 TimTec1_002700 C(=N/c1cccc2c(\N=C\c3ccco3)cccc12)\c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K17 compound treatment 124720.0 -14400.0 -0.24 129800.0 4200.0 0.07 -0.121 -0.4894 3209112 TimTec1_002701 Cc1ccc2nc(sc2c1)c3ccc(NC(=O)Nc4ccccc4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K18 compound treatment 74080.0 -65100.0 -1.07 82560.0 -43000.0 -0.69 -1.2445 -0.9766 3209113 TimTec1_002702 Cc1ccc(/C=N/c2ccccc2OCc3ccccc3)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K19 compound treatment 124640.0 -14500.0 -0.24 114040.0 -11600.0 -0.18 -0.2995 -0.9917 3084165 TimTec1_002703 N#Cc1cc2CCCc2nc1SCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K20 compound treatment 91320.0 -47800.0 -0.79 87640.0 -38000.0 -0.61 -0.986 -0.9914 1504412 TimTec1_002704 Fc1ccc(CN2CCN(Cc3ccccc3)CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K21 compound treatment 43440.0 -95700.0 -1.58 33880.0 -91700.0 -1.46 -2.1508 -0.9993 3084167 TimTec1_002705 CCOc1ccccc1/C=N/c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K22 compound treatment 88280.0 -50900.0 -0.84 103280.0 -22300.0 -0.36 -0.8452 -0.927 3209114 TimTec1_002706 COc1cccc(c1)C(=O)N2N=C(O)C=CC2=C(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K23 mock treatment 114920.0 -24200.0 -0.4 109720.0 -15900.0 -0.25 -0.4617 -0.9757 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 K24 mock treatment 104760.0 -34400.0 -0.57 127280.0 1680.0 0.03 -0.3824 -0.6731 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L01 compound treatment 90960.0 -48200.0 -0.8 106880.0 -18700.0 -0.3 -0.7734 -0.9105 1454168 TimTec1_002707 COc1cc(OC)nc(n1)C(=O)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L02 compound treatment 122320.0 -16800.0 -0.28 117920.0 -7680.0 -0.12 -0.2829 -0.9324 1013845 TimTec1_002708 OC(=O)C1CCN(CC1)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L03 compound treatment 82120.0 -57000.0 -0.94 93280.0 -32300.0 -0.52 -1.0298 -0.9598 3084171 TimTec1_002709 SC1=N(/N=C/2\C(=O)Nc3ccccc23)C(=O)C4C=CC=CC4=N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L04 compound treatment 91400.0 -47700.0 -0.79 100840.0 -24800.0 -0.39 -0.8363 -0.9489 1202182 TimTec1_002710 NC1=C(C#N)C(=C(C#N)C#N)C(O1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L05 compound treatment 129200.0 -9940.0 -0.16 112640.0 -13000.0 -0.21 -0.2621 -0.9935 1265429 TimTec1_002711 CC1(C)CC(=O)C(C(C2C(=O)CC(C)(C)CC2=O)c3ccc(F)cc3O)C(=O)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L06 compound treatment 129320.0 -9820.0 -0.16 129360.0 3760.0 0.06 -0.0723 -0.4183 3084174 TimTec1_002712 COc1ccc(cc1OC)/C(=N/O)/c2nccc3cc(OC)c(OC)cc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L07 compound treatment 77000.0 -62100.0 -1.03 86800.0 -38800.0 -0.62 -1.1626 -0.9707 1260243 TimTec1_002713 S=c1nc(c2ccco2)c3c(=S)[nH]c(=S)[nH]c3[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L08 compound treatment 140080.0 943.0 0.02 125240.0 -364.0 -0.01 0.0069 0.4157 1599464 TimTec1_002714 CC1CN(CCC1=O)C2CC(C)(C)NC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L09 compound treatment 125560.0 -13600.0 -0.22 123720.0 -1880.0 -0.03 -0.1797 -0.7947 1384770 TimTec1_002715 CN(C)c1ccc(cc1)C2OCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L10 compound treatment 139640.0 503.0 0.01 121360.0 -4240.0 -0.07 -0.042 -0.6158 1608667 TimTec1_002716 NC(=O)CNC(=O)c1ccc2ccccc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L11 compound treatment 16080.0 -123000.0 -2.03 32760.0 -92800.0 -1.48 -2.4827 -0.9879 3209115 TimTec1_002717 COC(=O)CNS(=O)(=O)Nc1ccc(cc1)c2nc3ccc(C)cc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L12 compound treatment 41920.0 -97200.0 -1.6 37880.0 -87700.0 -1.4 -2.1234 -0.9976 1678540 TimTec1_002718 Clc1ccc2n(CCC(=O)n3c(=O)oc4cc(Cl)ccc34)c(=O)oc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L13 compound treatment 53520.0 -85600.0 -1.41 55280.0 -70300.0 -1.12 -1.7919 -0.9934 1920767 TimTec1_002719 Cc1cc(c2ccco2)n(n1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L14 compound treatment 135400.0 -3740.0 -0.06 131520.0 5920.0 0.09 0.0231 0.2046 3084178 TimTec1_002720 CCOC(=O)Cc1nnn[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L15 compound treatment 123640.0 -15500.0 -0.26 129360.0 3760.0 0.06 -0.1386 -0.5274 3209116 TimTec1_002721 Brc1ccc(cc1)C(=S)N2CCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L16 compound treatment 114240.0 -24900.0 -0.41 119440.0 -6160.0 -0.1 -0.3601 -0.8521 1354769 TimTec1_002722 CC(C)COC(=O)NCc1ccc2OCOc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L17 compound treatment 109360.0 -29800.0 -0.49 119280.0 -6320.0 -0.1 -0.4188 -0.8347 3209117 TimTec1_002723 Cc1ccc(cc1)[C@H]2[C@@H](C#N)[C@H](C#N)N3CCCN23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L18 compound treatment 120040.0 -19100.0 -0.32 118560.0 -7040.0 -0.11 -0.3023 -0.9034 71735 TimTec1_002724 COc1ccc(CC2NCCc3cc(OC)c(OC)cc23)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L19 compound treatment 115840.0 -23300.0 -0.38 118280.0 -7320.0 -0.12 -0.3545 -0.882 3084252 TimTec1_002725 CC1(C)OC(=O)N(C1=C)c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L20 compound treatment 107600.0 -31500.0 -0.52 103400.0 -22200.0 -0.35 -0.6184 -0.9823 3084253 TimTec1_002726 CC(=O)N1C2CC(C=C2)C1(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L21 compound treatment 95400.0 -43700.0 -0.72 97560.0 -28000.0 -0.45 -0.8266 -0.9734 1279868 TimTec1_002727 CCc1ccc(cc1)S(=O)(=O)N2CCC(CC2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L22 compound treatment 65920.0 -73200.0 -1.21 62800.0 -62800.0 -1.0 -1.5624 -0.9956 1355496 TimTec1_002728 Cc1ccc(CSCC(=O)Nc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L23 mock treatment 115280.0 -23900.0 -0.39 117240.0 -8360.0 -0.13 -0.3727 -0.8965 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 L24 mock treatment 102760.0 -36400.0 -0.6 118720.0 -6880.0 -0.11 -0.5022 -0.8227 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M01 compound treatment 113280.0 -25900.0 -0.43 140040.0 14400.0 0.23 -0.1391 -0.2869 1520938 TimTec1_002729 Cn1c2ccccc2c3nn(c4ccccc4)c(=O)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M02 compound treatment 70920.0 -68200.0 -1.13 88800.0 -36800.0 -0.59 -1.211 -0.9538 3209118 TimTec1_002730 NS(=O)(=O)c1ccc(/N=C/c2c3ccccc3cc4ccccc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M03 compound treatment 7160.0 -132000.0 -2.18 7480.0 -118000.0 -1.88 -2.8718 -0.9974 3084256 TimTec1_002731 CC(C)(C)c1ccc(OCCNC(=O)c2cccc(Br)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M04 compound treatment 50120.0 -89000.0 -1.47 43840.0 -81800.0 -1.3 -1.9605 -0.9982 3209119 TimTec1_002732 O=C(Nc1cccc(C#N)c1)/C=C/c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M05 compound treatment 9240.0 -130000.0 -2.14 12680.0 -113000.0 -1.8 -2.7889 -0.9962 3084258 TimTec1_002733 Cc1ccc(cc1)N2C(SCC2=O)/C=C/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M06 compound treatment 137520.0 -1620.0 -0.03 120040.0 -5560.0 -0.09 -0.0816 -0.8809 3209120 TimTec1_002734 C=CCC1(CC=C)CCCCN1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M07 compound treatment 26000.0 -113000.0 -1.87 53320.0 -72300.0 -1.15 -2.1352 -0.9731 3209121 TimTec1_002735 Cc1nc(NCc2ccco2)c3cc(sc3n1)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M08 compound treatment 53400.0 -85700.0 -1.42 43720.0 -81900.0 -1.31 -1.9236 -0.9992 3084261 TimTec1_002736 Ic1ccc(/N=C/c2ccc(C#N)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M09 compound treatment 101160.0 -38000.0 -0.63 87160.0 -38400.0 -0.61 -0.8766 -0.9999 3209238 TimTec1_002737 COc1ccc(OC)c(/C=c/2\sc3nnc(c4ccccc4Cl)n3c2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M10 compound treatment 42560.0 -96600.0 -1.59 37040.0 -88600.0 -1.41 -2.1254 -0.9982 3084262 TimTec1_002738 COc1ccc(/N=C/c2ccccc2OCc3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M11 compound treatment 120280.0 -18900.0 -0.31 123760.0 -1840.0 -0.03 -0.2409 -0.7704 3209239 TimTec1_002739 C/C(=N/CCO)/c1c([nH]n(c2nc3ccccc3s2)c1=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M12 compound treatment 131360.0 -7780.0 -0.13 118520.0 -7080.0 -0.11 -0.1706 -0.9979 3084263 TimTec1_002740 Cc1ccccc1/C=N/c2ccccc2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M13 compound treatment 137320.0 -1820.0 -0.03 127280.0 1680.0 0.03 -0.0023 -0.0578 3209240 TimTec1_002741 COC(=O)N(C)c1ccccc1C(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M14 compound treatment 55200.0 -83900.0 -1.39 61640.0 -64000.0 -1.02 -1.7006 -0.9886 3084265 TimTec1_002742 CCCOC(=O)c1ccc(/N=C/c2ccc(C)s2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M15 compound treatment 111040.0 -28100.0 -0.46 127200.0 1600.0 0.03 -0.31 -0.6673 1321825 TimTec1_002743 CC(Oc1ccc(Cl)cc1Cl)C(=O)NN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M16 compound treatment 97920.0 -41200.0 -0.68 116680.0 -8920.0 -0.14 -0.5817 -0.8368 3084267 TimTec1_002744 COc1cc(/C=N/c2ccc(cc2)C(=O)c3ccccc3)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M17 compound treatment 76680.0 -62500.0 -1.03 97440.0 -28200.0 -0.45 -1.0464 -0.9306 1712191 TimTec1_002745 Cc1ccc(cc1I)C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M18 compound treatment 9760.0 -129000.0 -2.14 16560.0 -109000.0 -1.74 -2.7391 -0.9948 3209241 TimTec1_002746 CCCC(=O)c1ccc(/N=C/c2ccc(Cl)cc2Cl)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M19 compound treatment 112640.0 -26500.0 -0.44 126520.0 916.0 0.01 -0.299 -0.6831 3084269 TimTec1_002747 Brc1ccc(/C=N/c2ccccc2C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M20 compound treatment 80600.0 -58500.0 -0.97 87120.0 -38500.0 -0.61 -1.117 -0.9759 1423653 TimTec1_002748 COc1ccc(NC(=O)c2ccc(Cn3cc(Cl)cn3)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M21 compound treatment 7040.0 -132000.0 -2.18 9600.0 -116000.0 -1.85 -2.8493 -0.9966 3084271 TimTec1_002749 Cc1nn(C(=S)N)c(O)c1C(C(C#N)C#N)c2cccc(Cl)c2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M22 compound treatment 90040.0 -49100.0 -0.81 101200.0 -24400.0 -0.39 -0.8481 -0.9434 3209242 TimTec1_002750 NC(=O)Oc1ccc(I)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M23 mock treatment 117120.0 -22000.0 -0.36 131720.0 6120.0 0.1 -0.1881 -0.4998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 M24 mock treatment 96400.0 -42700.0 -0.71 134360.0 8760.0 0.14 -0.4002 -0.5564 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N01 compound treatment 57800.0 -81300.0 -1.34 77880.0 -47700.0 -0.76 -1.4873 -0.9638 3083254 TimTec1_002751 Cc1cc2nnc(c3cccc4OCOc43)n2c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N02 compound treatment 10400.0 -129000.0 -2.13 59720.0 -65900.0 -1.05 -2.2452 -0.9472 3083257 TimTec1_002752 C/C=C\1/C(C)C(C(=C(N)N1c2ccc(cc2)C(=O)N)C#N)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N03 compound treatment 109520.0 -29600.0 -0.49 121400.0 -4200.0 -0.07 -0.3931 -0.7966 1231981 TimTec1_002753 Cc1ccc(cc1)C(=O)Cc2nc3ncccc3[nH]c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N04 compound treatment 108160.0 -31000.0 -0.51 123080.0 -2520.0 -0.04 -0.39 -0.7604 1274147 TimTec1_002754 Sc1nc(CCN2C(=O)c3ccccc3C2=O)n[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N05 compound treatment 113920.0 -25200.0 -0.42 127200.0 1600.0 0.03 -0.2764 -0.6627 3083260 TimTec1_002755 CC(=S)N1CCN(CC1)C(=S)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N06 compound treatment 117160.0 -22000.0 -0.36 117320.0 -8280.0 -0.13 -0.3499 -0.9063 1517166 TimTec1_002756 Cc1ccccc1N2C(=O)c3ccccc3NC2(C)CC(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N07 compound treatment 34480.0 -105000.0 -1.73 61080.0 -64500.0 -1.03 -1.9488 -0.9693 1118059 TimTec1_002757 Nn1c(=O)c(Cc2ccco2)n[nH]c1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N08 compound treatment 121720.0 -17400.0 -0.29 116320.0 -9280.0 -0.15 -0.3079 -0.9523 1361841 TimTec1_002758 CCOC(=O)C1=C(NC(=S)C(CC=C)(C#N)C1c2cccnc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N09 compound treatment 109720.0 -29400.0 -0.49 124000.0 -1600.0 -0.03 -0.3614 -0.7433 3083263 TimTec1_002759 COC(=O)CNc1cc(C)c(cc1OC)C(O)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N10 compound treatment 117840.0 -21300.0 -0.35 120840.0 -4760.0 -0.08 -0.3023 -0.8404 1187305 TimTec1_002760 CCCC(=O)Nc1ccc2[nH]c(=O)[nH]c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N11 compound treatment 69560.0 -69600.0 -1.15 78040.0 -47600.0 -0.76 -1.3482 -0.9797 1455249 TimTec1_002761 CC(=O)Oc1ccc2occ(C(=O)c3ccc(F)cc3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N12 compound treatment 120120.0 -19000.0 -0.31 119680.0 -5920.0 -0.09 -0.2887 -0.8808 1149353 TimTec1_002762 COc1ccc(cc1)C(C#N)N2N=C(C)CC2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N13 compound treatment 125720.0 -13400.0 -0.22 119200.0 -6400.0 -0.1 -0.2288 -0.9381 1491757 TimTec1_002763 Clc1cccc(NC(=O)C(NC=O)c2ccccc2Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N14 compound treatment 131040.0 -8100.0 -0.13 115960.0 -9640.0 -0.15 -0.2032 -0.9976 3209243 TimTec1_002764 OC(=O)[C@@H]1CCCN1Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N15 compound treatment 116520.0 -22600.0 -0.37 120840.0 -4760.0 -0.08 -0.3177 -0.8338 3083267 TimTec1_002765 OC(=O)CCc1nnc(S)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N16 compound treatment 98520.0 -40600.0 -0.67 114800.0 -10800.0 -0.17 -0.5959 -0.8608 1446498 TimTec1_002766 O=C(NC1CCCCCCCCCCC1)c2nc[nH]n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N17 compound treatment 97600.0 -41500.0 -0.69 127320.0 1720.0 0.03 -0.4655 -0.6784 3209244 TimTec1_002767 COc1ccc(cc1)[C@H]2[C@@H](C#N)[C@H](C#N)N3CCCN23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N18 compound treatment 97600.0 -41500.0 -0.69 128360.0 2760.0 0.04 -0.4538 -0.6604 1206859 TimTec1_002768 Brc1cncc(c1)C(=O)Nc2ccc(cc2)C(=O)NC3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N19 compound treatment 108600.0 -30500.0 -0.5 116520.0 -9080.0 -0.14 -0.4588 -0.8748 1560261 TimTec1_002769 COc1ccc(cc1)C2NCCc3cc(OC)c(OC)cc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N20 compound treatment 7200.0 -132000.0 -2.18 11320.0 -114000.0 -1.82 -2.828 -0.9961 3209245 TimTec1_002770 CN(C)c1nc(NCc2ccccc2)nc(Nc3ccc(OC(F)(F)F)cc3)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N21 compound treatment 99080.0 -40100.0 -0.66 125520.0 -83.8 0.0 -0.4685 -0.7085 1425208 TimTec1_002771 CN(CC(=O)O)S(=O)(=O)c1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N22 compound treatment 76240.0 -62900.0 -1.04 118720.0 -6880.0 -0.11 -0.8117 -0.7775 3209246 TimTec1_002772 Nn1c(CSCc2ccccc2)nnc1CSCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N23 mock treatment 103520.0 -35600.0 -0.59 126200.0 596.0 0.01 -0.409 -0.6956 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 N24 mock treatment 105560.0 -33600.0 -0.55 121040.0 -4560.0 -0.07 -0.4434 -0.7931 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O01 compound treatment 122520.0 -16600.0 -0.27 128440.0 2840.0 0.05 -0.162 -0.5827 3083272 TimTec1_002773 C(Nc1nonc1c2ncon2)n3nnc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O02 compound treatment 118880.0 -20300.0 -0.33 110080.0 -15500.0 -0.25 -0.4114 -0.989 3209247 TimTec1_002774 O=C(NC1CCCCC1)/C=C/c2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O03 compound treatment 48600.0 -90500.0 -1.49 61280.0 -64300.0 -1.03 -1.7817 -0.9831 3209248 TimTec1_002775 O=C(NCCc1ccccc1)c2c(/N=C/3\C(=O)Nc4ccccc34)sc5CCCCc25 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O04 compound treatment 66440.0 -72700.0 -1.2 100000.0 -25600.0 -0.41 -1.1371 -0.8971 1468374 TimTec1_002776 OC(c1cccs1)c2ccc3OCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O05 compound treatment 6640.0 -132000.0 -2.19 11320.0 -114000.0 -1.82 -2.8346 -0.9959 3209249 TimTec1_002777 Clc1ccc(Cl)c(c1)N2C(SCC2=O)/C=C/c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O06 compound treatment 67720.0 -71400.0 -1.18 92040.0 -33600.0 -0.53 -1.2119 -0.9361 1257164 TimTec1_002778 Cc1ccc(C)c(NCc2ccccc2CO)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O07 compound treatment 6240.0 -133000.0 -2.19 26640.0 -99000.0 -1.58 -2.6666 -0.9869 3083858 TimTec1_002779 Cc1nc2ccccc2nc1Sc3nnc(o3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O08 compound treatment 27840.0 -111000.0 -1.84 39000.0 -86600.0 -1.38 -2.2752 -0.9901 1918856 TimTec1_002780 Brc1ccc(/C=N/c2cccc3ccccc23)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O09 compound treatment 7120.0 -132000.0 -2.18 23080.0 -103000.0 -1.63 -2.6964 -0.9899 3209250 TimTec1_002781 COc1ccc(Br)cc1/C=C/2\C(=O)NC(=O)N(CCC3=CCCCC3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O10 compound treatment 89360.0 -49800.0 -0.82 100840.0 -24800.0 -0.39 -0.8601 -0.9436 3209251 TimTec1_002782 N#Cc1ccc(/C=N/c2cccc(C#N)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O11 compound treatment 104520.0 -34600.0 -0.57 101120.0 -24500.0 -0.39 -0.68 -0.9827 3083924 TimTec1_002783 CCN1C(=C)c2cc(C)cc(C)c2NC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O12 compound treatment 108160.0 -31000.0 -0.51 121160.0 -4440.0 -0.07 -0.4117 -0.7974 3209252 TimTec1_002784 COc1ccc2ccccc2c1/C=N/c3ccccc3C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O13 compound treatment 51800.0 -87300.0 -1.44 90160.0 -35400.0 -0.56 -1.4189 -0.9163 1178846 TimTec1_002785 C=CCSc1nc2ccccc2c(=O)n1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O14 compound treatment 115520.0 -23600.0 -0.39 127920.0 2320.0 0.04 -0.2496 -0.6373 3209253 TimTec1_002786 Cc1ccc(/C=N/c2ccc(\N=C\c3ccc(C)s3)cc2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O15 compound treatment 18040.0 -121000.0 -2.0 66840.0 -58800.0 -0.94 -2.0758 -0.9403 1364793 TimTec1_002787 CC(Oc1ccc(Cl)cc1Cl)C(=O)Nc2sc(C)c(C)c2C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O16 compound treatment 8560.0 -131000.0 -2.16 27200.0 -98400.0 -1.57 -2.6332 -0.9878 3209254 TimTec1_002788 Cc1c(Cc2ccccc2)sc(/N=C/c3ccc(Cl)cc3)c1C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O17 compound treatment 102840.0 -36300.0 -0.6 120680.0 -4920.0 -0.08 -0.4792 -0.7929 1685792 TimTec1_002789 COc1ccc2c(Cl)c(sc2c1)C(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O18 compound treatment 47240.0 -91900.0 -1.52 73240.0 -52400.0 -0.83 -1.6628 -0.9604 1138448 TimTec1_002790 O=C(CSc1nc2CCCCc2cc1C#N)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O19 compound treatment 111920.0 -27200.0 -0.45 130440.0 4840.0 0.08 -0.2632 -0.5774 3083928 TimTec1_002791 CSc1ccc(/C=N/c2ccc(C)c(C)c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O20 compound treatment 6000.0 -133000.0 -2.2 10360.0 -115000.0 -1.84 -2.8529 -0.996 1253093 TimTec1_002792 CCOc1cccc(=O)c2c(C)n(c(C)c12)c3ccc(OC)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O21 compound treatment 104800.0 -34300.0 -0.57 178160.0 52600.0 0.84 0.1915 0.1894 3083930 TimTec1_002793 Cc1ccc(/C=N/c2ccc3ccccc3c2)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O22 compound treatment 101600.0 -37500.0 -0.62 131000.0 5400.0 0.09 -0.3773 -0.6032 3209255 TimTec1_002794 C/C(=N/Cc1nnc(C)s1)/c2cc3c(=O)n(C)c4ccccc4c3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O23 mock treatment 124720.0 -14400.0 -0.24 141320.0 15700.0 0.25 0.0088 0.0256 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 O24 mock treatment 113000.0 -26100.0 -0.43 128240.0 2640.0 0.04 -0.2754 -0.6352 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P01 compound treatment 118640.0 -20500.0 -0.34 105760.0 -19800.0 -0.32 -0.4629 -0.9994 3083932 TimTec1_002795 CC1=CC(=O)N(C1=O)c2c(C)n(C)n(c3ccccc3)c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P02 compound treatment 122160.0 -17000.0 -0.28 117160.0 -8440.0 -0.13 -0.2933 -0.9435 3209256 TimTec1_002796 CNC(=O)C1=CC(C)(C)NC1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P03 compound treatment 100240.0 -38900.0 -0.64 107240.0 -18400.0 -0.29 -0.661 -0.9367 1174268 TimTec1_002797 Clc1ccc(cc1)C(=O)C(=C2NCCN2)n3ccnc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P04 compound treatment 108080.0 -31100.0 -0.51 122080.0 -3520.0 -0.06 -0.4022 -0.7799 1414675 TimTec1_002798 O=C(N1CCOCC1)c2ccc(s2)C(=O)N3CCOCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P05 compound treatment 102360.0 -36800.0 -0.61 165200.0 39600.0 0.63 0.017 0.0194 1495833 TimTec1_002799 COc1ccc(cc1OC)C2=NCC(C)(C)CO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P06 compound treatment 4200.0 -135000.0 -2.23 6880.0 -119000.0 -1.89 -2.9131 -0.9967 1678629 TimTec1_002800 COc1ccccc1C(=O)Nc2ccc(cc2)c3cn4ccccc4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P07 compound treatment 83520.0 -55600.0 -0.92 117800.0 -7800.0 -0.12 -0.7371 -0.7956 3209373 TimTec1_002801 CCn1c(=O)c(C/2=NNC(=O)\C2=C/Nc3nccs3)c(O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P08 compound treatment 75640.0 -63500.0 -1.05 106720.0 -18900.0 -0.3 -0.954 -0.8748 1514165 TimTec1_002802 COc1ccc(cc1)C(C#N)N2CCC(=N2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P09 compound treatment 72280.0 -66900.0 -1.1 117360.0 -8240.0 -0.13 -0.8733 -0.7857 1619442 TimTec1_002803 Nc1cccc(c1)C(=O)OC2CSC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P10 compound treatment 54200.0 -84900.0 -1.4 99600.0 -26000.0 -0.41 -1.2845 -0.8785 3209374 TimTec1_002804 Cc1ccc(OCCSc2ncnc3ccccc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P11 compound treatment 98720.0 -40400.0 -0.67 135240.0 9640.0 0.15 -0.3632 -0.5305 1011278 TimTec1_002805 OC(=O)CNC(=O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P12 compound treatment 100960.0 -38200.0 -0.63 133200.0 7600.0 0.12 -0.36 -0.561 1159913 TimTec1_002806 NC(=O)Cc1nc(cs1)c2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P13 compound treatment 102520.0 -36600.0 -0.6 123360.0 -2240.0 -0.04 -0.4527 -0.7476 1445633 TimTec1_002807 CCC(=O)c1cc2OCCOc2cc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P14 compound treatment 106440.0 -32700.0 -0.54 123640.0 -1960.0 -0.03 -0.4038 -0.7469 1468490 TimTec1_002808 Clc1ccccc1CS(=O)(=O)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P15 compound treatment 90120.0 -49000.0 -0.81 117560.0 -8040.0 -0.13 -0.6628 -0.8091 1633493 TimTec1_002809 NC(=O)CSc1nc2ccccc2c(=O)n1Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P16 compound treatment 104600.0 -34500.0 -0.57 127920.0 2320.0 0.04 -0.377 -0.6599 1674139 TimTec1_002810 CCOC(=O)C1CCN(CC1)C(=O)c2ccccc2NC(=O)c3cccc(F)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P17 compound treatment 87160.0 -52000.0 -0.86 123360.0 -2240.0 -0.04 -0.632 -0.7359 1703140 TimTec1_002811 OC(=O)CC1(O)N(Cc2ccccc2)C(=O)c3ccccc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P18 compound treatment 93760.0 -45400.0 -0.75 135680.0 10100.0 0.16 -0.4161 -0.5432 3084009 TimTec1_002812 COC(=O)C1=CN(CC2CCCO2)C=C(C1c3ccccc3)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P19 compound treatment 73960.0 -65200.0 -1.08 122560.0 -3040.0 -0.05 -0.7951 -0.7382 1281947 TimTec1_002813 CC1(C)CC(=C(C(C(C#N)C(=S)N)c2ccc(Cl)cc2)C(=O)C1)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P20 compound treatment 82920.0 -56200.0 -0.93 110000.0 -15600.0 -0.25 -0.832 -0.866 3084012 TimTec1_002814 O=C(C1CCCC1)N2CCc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P21 compound treatment 98640.0 -40500.0 -0.67 119520.0 -6080.0 -0.1 -0.5413 -0.8013 1667550 TimTec1_002815 Clc1ccccc1C(=O)N2CC(CC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P22 compound treatment 109480.0 -29700.0 -0.49 109920.0 -15700.0 -0.25 -0.5229 -0.9513 3209375 TimTec1_002816 CC(=O)NC(N1CCCCC1c2cccnc2)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P23 mock treatment 113600.0 -25500.0 -0.42 118200.0 -7400.0 -0.12 -0.3815 -0.8715 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2070 P24 mock treatment 118360.0 -20800.0 -0.34 116280.0 -9320.0 -0.15 -0.3476 -0.9299 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A01 compound treatment 109480.0 7310.0 0.12 72840.0 -18800.0 -0.3 -0.127 -0.3925 1179025 TimTec1_005281 Cc1c(OCC(=O)O)ccc2c(cc(=O)oc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A02 compound treatment 91160.0 -11000.0 -0.18 81000.0 -10700.0 -0.17 -0.2489 -0.9995 3212329 TimTec1_005282 C(=N/c1nccs1)\c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A03 compound treatment 105960.0 3790.0 0.06 128760.0 37100.0 0.59 0.4621 0.7776 1341807 TimTec1_005283 CCc1cc2c(=O)c(c3nc4ccccc4s3)c(C)oc2c(CN(C)C)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A04 compound treatment 61680.0 -40500.0 -0.67 75120.0 -16600.0 -0.26 -0.6593 -0.9174 3086205 TimTec1_005284 Cc1cc(C)c(C#N)c(SCC(=O)c2ccccc2)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A05 compound treatment 46080.0 -56100.0 -0.93 65760.0 -25900.0 -0.41 -0.9469 -0.9339 1015158 TimTec1_005285 COC(=O)c1ccc(NN)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A06 compound treatment 51200.0 -51000.0 -0.84 146200.0 54500.0 0.87 0.0195 0.0161 1579854 TimTec1_005286 Nc1nc(cs1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A07 compound treatment 15400.0 -86800.0 -1.43 54160.0 -37500.0 -0.6 -1.4357 -0.925 3086207 TimTec1_005287 CC(C)c1cc(I)c(C)cc1OC(=O)NC(=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A08 compound treatment 47800.0 -54400.0 -0.9 163400.0 71700.0 1.14 0.1736 0.1195 1603281 TimTec1_005288 O=C(NCc1ccccc1)C2CCCN2C(=O)OCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A09 compound treatment 10360.0 -91800.0 -1.52 33680.0 -58000.0 -0.92 -1.7253 -0.9719 1494738 TimTec1_005289 O=C(Cn1c(=S)[nH]c2ccccc12)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A10 compound treatment 20200.0 -82000.0 -1.35 69400.0 -22300.0 -0.36 -1.2079 -0.8634 1405927 TimTec1_005290 Cc1cc(C)c(c(C)c1)S(=O)(=O)NCC2(OC3C=C2)C4C3C(=O)N(C4=O)c5ccc(Cl)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A11 compound treatment 61760.0 -40400.0 -0.67 192800.0 101000.0 1.61 0.6679 0.3829 1153776 TimTec1_005291 Cc1c(CCC(=O)NN)c(C)n2c3ccccc3nc2c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A12 compound treatment 94240.0 -7930.0 -0.13 188440.0 96800.0 1.54 0.9979 0.6448 3086211 TimTec1_005292 COc1cc(/C=N/Cc2ccco2)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A13 compound treatment 114960.0 12800.0 0.21 196520.0 105000.0 1.67 1.3308 0.7902 1733511 TimTec1_005293 CC1(C)CC(CCO1)C(=O)COc2ccc3ccc(=O)oc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A14 compound treatment 104000.0 1830.0 0.03 197120.0 105000.0 1.68 1.2097 0.7197 1139337 TimTec1_005294 C(Oc1ccccc1OCc2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A15 compound treatment 91720.0 -10500.0 -0.17 177400.0 85700.0 1.37 0.8441 0.6129 3212403 TimTec1_005295 O=C(NC(SC1=NCCS1)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A16 compound treatment 73760.0 -28400.0 -0.47 200320.0 109000.0 1.73 0.8928 0.4977 3086214 TimTec1_005296 CC(C)(CCN1CCOCC1)NC(=O)C=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A17 compound treatment 74960.0 -27200.0 -0.45 184480.0 92800.0 1.48 0.7282 0.4711 1301247 TimTec1_005297 COc1cc2c(C(=O)O)c(C)oc2cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A18 compound treatment 79000.0 -23200.0 -0.38 200400.0 109000.0 1.73 0.9548 0.5381 1734603 TimTec1_005298 CC1(C)CC(=O)C2=C(C1)OC(=C(C#N)C2c3ccoc3)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A19 compound treatment 67560.0 -34600.0 -0.57 149080.0 57400.0 0.91 0.2429 0.2252 3212404 TimTec1_005299 CN1CCc2[nH]c(=S)c(C#N)c(c3ccccc3)c2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A20 compound treatment 60880.0 -41300.0 -0.68 126120.0 34400.0 0.55 -0.0938 -0.1072 3086280 TimTec1_005300 COC(=O)/C=C\1/Nc2ccccc2SC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A21 compound treatment 32240.0 -69900.0 -1.15 50320.0 -41400.0 -0.66 -1.2824 -0.9647 3212405 TimTec1_005301 Cc1cccc(NCN2C(=O)S/C(=C\c3cccc(F)c3)/C2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A22 compound treatment 4000.0 -98200.0 -1.62 4880.0 -86800.0 -1.38 -2.1242 -0.9969 1421857 TimTec1_005302 COc1ccc(cc1OC)C(=O)Nc2nnc(o2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A23 mock treatment 110200.0 8030.0 0.13 99880.0 8200.0 0.13 0.1861 1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 A24 mock treatment 93920.0 -8250.0 -0.14 46320.0 -45400.0 -0.72 -0.6075 -0.8258 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B01 compound treatment 102880.0 709.0 0.01 105080.0 13400.0 0.21 0.1593 0.7447 3212406 TimTec1_005303 CC(C)P(C(C)C)c1ccc(C#N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B02 compound treatment 54720.0 -47500.0 -0.78 74200.0 -17500.0 -0.28 -0.7509 -0.9032 3212407 TimTec1_005304 CC(C)COc1ccc(/C=C\2/S\C(=N/c3ccccc3)\N(N(C)C)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B03 compound treatment 109280.0 7110.0 0.12 184920.0 93200.0 1.49 1.1338 0.7606 1371685 TimTec1_005305 O=C(NCc1cccnc1)c2cc3ccccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B04 compound treatment 97280.0 -4890.0 -0.08 209640.0 118000.0 1.88 1.2723 0.6761 3086285 TimTec1_005306 COc1cc(OC)c(/C=N/c2ccccc2)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B05 compound treatment 139000.0 36800.0 0.61 216640.0 125000.0 1.99 1.8382 0.8827 1138064 TimTec1_005307 OP(=O)(CCN1CCCC1=O)CN2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B06 compound treatment 84280.0 -17900.0 -0.3 181320.0 89600.0 1.43 0.8014 0.5493 1556230 TimTec1_005308 COc1ccc2CCC(C(=O)c2c1)C3(O)C(=O)Nc4ccccc43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B07 compound treatment 37520.0 -64700.0 -1.07 129120.0 37400.0 0.6 -0.3327 -0.2721 3086287 TimTec1_005309 CCC(NC(=O)Oc1ccc2ccccc2c1)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B08 compound treatment 55480.0 -46700.0 -0.77 210160.0 118000.0 1.89 0.7903 0.3875 1141795 TimTec1_005310 CCC(Sc1nnc2c3ccccc3n(C)c2n1)C(=O)Nc4ccccc4C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B09 compound treatment 31160.0 -71000.0 -1.17 46040.0 -45600.0 -0.73 -1.3433 -0.9737 3086290 TimTec1_005311 Cc1ccc2cccc(SCc3ccc(Br)cc3)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B10 compound treatment 62880.0 -39300.0 -0.65 199400.0 108000.0 1.72 0.7554 0.4116 1716446 TimTec1_005312 Clc1cc(NC2CCCCC2)c3C(=O)c4ccccc4-c5onc1c53 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B11 compound treatment 7240.0 -94900.0 -1.57 19440.0 -72200.0 -1.15 -1.9222 -0.9885 3212408 TimTec1_005313 COc1cc(ccc1O)c2nc3ccccn3c2/N=C/c4cccc(Cl)c4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B12 compound treatment 122040.0 19900.0 0.33 200600.0 109000.0 1.74 1.4595 0.8261 1140826 TimTec1_005314 OC1(CCN([C@@H]2CCCC[C@@H]21)C(=O)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B13 compound treatment 140920.0 38700.0 0.64 212120.0 120000.0 1.92 1.8097 0.8944 1456412 TimTec1_005315 CN(CP(=O)(O)CCc1ccccc1)C=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B14 compound treatment 125360.0 23200.0 0.38 194720.0 103000.0 1.64 1.4319 0.8492 1674110 TimTec1_005316 Cc1ccc(C)c(NC(=O)C2CC(O)CN2C(=O)OC(C)(C)C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B15 compound treatment 89200.0 -13000.0 -0.21 205280.0 114000.0 1.81 1.1289 0.6192 3212409 TimTec1_005317 CCN(CC)S(=O)(=O)c1ncn[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B16 compound treatment 6280.0 -95900.0 -1.58 13960.0 -77700.0 -1.24 -1.9952 -0.9926 3212410 TimTec1_005318 Oc1ccccc1/C=C\2/S\C(=N/c3ccccc3)\N(Cc4ccccc4)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B17 compound treatment 94680.0 -7490.0 -0.12 226160.0 134000.0 2.14 1.4282 0.6652 1238350 TimTec1_005319 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)Oc2cccc(c2)c3cnc4ccccc4n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B18 compound treatment 5560.0 -96600.0 -1.59 12320.0 -79400.0 -1.26 -2.0221 -0.9934 1373281 TimTec1_005320 OC(C#CC(O)(c1ccccc1)c2ccccc2)c3ccc(F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B19 compound treatment 80120.0 -22100.0 -0.36 154120.0 62400.0 1.0 0.4463 0.4212 1306989 TimTec1_005321 COc1ccc2N(Cn3nc(c4ccccc4)n(c5ccccc5)c3=S)CCCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B20 compound treatment 122320.0 20100.0 0.33 206120.0 114000.0 1.82 1.5249 0.8225 1546728 TimTec1_005322 O=C(c1ccccc1)c2nc3ccccc3[nH]c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B21 compound treatment 5480.0 -96700.0 -1.6 9080.0 -82600.0 -1.32 -2.0596 -0.9954 3086367 TimTec1_005323 COC(=O)C1=C(C)N(/C(=C/c2cccc3ccccc23)/C1=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B22 compound treatment 32160.0 -70000.0 -1.16 22400.0 -69300.0 -1.1 -1.598 -0.9997 3086369 TimTec1_005324 O=C(/C=C/c1ccco1)C2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B23 mock treatment 83840.0 -18300.0 -0.3 133320.0 41600.0 0.66 0.2553 0.35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 B24 mock treatment 105160.0 2990.0 0.05 111520.0 19800.0 0.32 0.2585 0.8077 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C01 compound treatment 67400.0 -34800.0 -0.57 103040.0 11400.0 0.18 -0.2778 -0.4617 1366978 TimTec1_005325 Cc1cc(=O)oc2cc(OC(=O)C3CCCN3C(=O)OC(C)(C)C)c(Cl)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C02 compound treatment 66320.0 -35900.0 -0.59 76880.0 -14800.0 -0.24 -0.5853 -0.9187 3086371 TimTec1_005326 NC1=C(C#N)C(c2ccccc2)c3ccc(N)cc3O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C03 compound treatment 100600.0 -1570.0 -0.03 145880.0 54200.0 0.86 0.5925 0.6856 1640630 TimTec1_005327 CCN(CC)Cc1c(O)ccc2cc(c3nc4ccccc4[nH]3)c(=O)oc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C04 compound treatment 11120.0 -91100.0 -1.5 21840.0 -69800.0 -1.11 -1.8499 -0.9891 1378375 TimTec1_005328 O=C(Oc1ccccc1OC(=O)C2C3CCCCC23)C4C5CCCCC45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C05 compound treatment 100400.0 -1770.0 -0.03 166400.0 74700.0 1.19 0.8214 0.6895 1495247 TimTec1_005329 Brc1ccc(OCC(=O)Nc2ccccc2N3C(=O)c4ccccc4C3=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C06 compound treatment 30440.0 -71700.0 -1.18 39320.0 -52400.0 -0.83 -1.4274 -0.9853 3212411 TimTec1_005330 C(=N/c1ccc2[nH]c(nc2c1)c3ccccc3)\c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C07 compound treatment 32520.0 -69700.0 -1.15 75360.0 -16300.0 -0.26 -0.9969 -0.8457 3212412 TimTec1_005331 CCOC(=O)NC1(N/C(=N/c2ccccc2)/N3CCOCC3)Oc4ccccc4O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C08 compound treatment 44160.0 -58000.0 -0.96 77840.0 -13800.0 -0.22 -0.8331 -0.8478 1281134 TimTec1_005332 COc1ccccc1NC(=O)C2CC2(c3ccc(C)cc3)c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C09 compound treatment 15640.0 -86500.0 -1.43 42240.0 -49400.0 -0.79 -1.5672 -0.9607 1467004 TimTec1_005333 Cc1cc(C)c(C(=O)Cn2c(=S)[nH]c3ccccc23)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C10 compound treatment 70120.0 -32100.0 -0.53 181280.0 89600.0 1.43 0.6357 0.4174 3086377 TimTec1_005334 COc1ccc(/C=N/CCN2Cc3ccccc3C2=O)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C11 compound treatment 73840.0 -28300.0 -0.47 165280.0 73600.0 1.17 0.4988 0.395 1653534 TimTec1_005335 CCOC(=O)CCc1c(C)c(C#N)c2nc3ccccc3n2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C12 compound treatment 94960.0 -7210.0 -0.12 145920.0 54200.0 0.86 0.5271 0.604 3086379 TimTec1_005336 Cc1cc(=O)oc2cc(OC(=O)/C=C/c3ccccc3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C13 compound treatment 100520.0 -1650.0 -0.03 166800.0 75100.0 1.2 0.8273 0.6908 3212413 TimTec1_005337 CC(C)NC(=O)n1cc(F)c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C14 compound treatment 95320.0 -6850.0 -0.11 200120.0 108000.0 1.73 1.1422 0.6594 3086381 TimTec1_005338 CC(C)COc1ccccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C15 compound treatment 82080.0 -20100.0 -0.33 166200.0 74500.0 1.19 0.6053 0.4909 1498433 TimTec1_005339 O=C(NC(OCc1ccccc1)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C16 compound treatment 57000.0 -45200.0 -0.75 148120.0 56400.0 0.9 0.1088 0.0931 3212414 TimTec1_005340 CN(C(=O)C)c1ccc(/N=C\2/C(=O)Nc3ccc(C)c(Br)c23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C17 compound treatment 42080.0 -60100.0 -0.99 157400.0 65700.0 1.05 0.0393 0.0272 3086384 TimTec1_005341 C1Cc2c(C1)c3ccccc3n2c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C18 compound treatment 19360.0 -82800.0 -1.37 33640.0 -58000.0 -0.93 -1.6207 -0.9819 1222403 TimTec1_005342 Nc1c(sc2snc(SCC(=O)c3ccccc3)c12)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C19 compound treatment 91280.0 -10900.0 -0.18 185640.0 94000.0 1.5 0.9318 0.6178 3086386 TimTec1_005343 CC(C)(C)NC(=O)CSc1nc(N)c(C#N)cc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C20 compound treatment 98440.0 -3730.0 -0.06 205000.0 113000.0 1.81 1.2336 0.6826 1290278 TimTec1_005344 COC(=O)C(CCCN1C(=O)c2ccccc2C1=O)(NC(=O)C)c3nn[nH]n3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C21 compound treatment 94160.0 -8010.0 -0.13 148960.0 57300.0 0.91 0.552 0.5984 3086388 TimTec1_005345 COc1ccc(cc1)c2nc3cc(/N=C/c4cccc(OC)c4O)ccc3o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C22 compound treatment 26640.0 -75500.0 -1.25 30480.0 -61200.0 -0.98 -1.5714 -0.9926 3212415 TimTec1_005346 COc1ccc(O)c(/C=N/c2cc(ccc2Oc3ccccc3)C(F)(F)F)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C23 mock treatment 77880.0 -24300.0 -0.4 150560.0 58900.0 0.94 0.38 0.3724 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 C24 mock treatment 76600.0 -25600.0 -0.42 81480.0 -10200.0 -0.16 -0.4134 -0.914 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D01 compound treatment 56240.0 -45900.0 -0.76 63320.0 -28400.0 -0.45 -0.8558 -0.9695 1377147 TimTec1_005347 CCC1=NN(C(=O)c2ccccc2F)C(O)(C1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D02 compound treatment 114600.0 12400.0 0.21 108920.0 17200.0 0.27 0.3394 0.9896 1581632 TimTec1_005348 OC(=O)CCC(=O)N(Cc1ccco1)C2CC(=O)N(C2=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D03 compound treatment 104040.0 1870.0 0.03 113840.0 22200.0 0.35 0.2715 0.766 1159067 TimTec1_005349 CC12C3CC(C=C3)C2C(=O)N(C1=O)c4cccc(c4)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D04 compound treatment 17960.0 -84200.0 -1.39 24520.0 -67200.0 -1.07 -1.7399 -0.9917 3086466 TimTec1_005350 OCCn/1c(cs\c1=N/c2ccccc2)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D05 compound treatment 68920.0 -33300.0 -0.55 81680.0 -10000.0 -0.16 -0.5008 -0.8763 1557266 TimTec1_005351 Clc1ccc(C(=O)Nc2ccc3nc(SCC(=O)N4CCOCC4)sc3c2)c(Cl)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D06 compound treatment 75680.0 -26500.0 -0.44 120640.0 29000.0 0.46 0.0172 0.027 3212725 TimTec1_005352 OC(=O)c1ccc(cc1)N2C(=O)CC(SC(=N)N3N=C(CC3c4ccccc4)c5ccccc5)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D07 compound treatment 79720.0 -22500.0 -0.37 131640.0 40000.0 0.64 0.1883 0.2555 3086469 TimTec1_005353 O=C(CSc1ncn[nH]1)OCN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D08 compound treatment 57360.0 -44800.0 -0.74 69760.0 -21900.0 -0.35 -0.7701 -0.9414 3086470 TimTec1_005354 CCN(CC)c1ccc(/C=C\2/S/C(=N\c3cccc(C)c3)/NC2=O)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D09 compound treatment 47720.0 -54500.0 -0.9 97000.0 5320.0 0.08 -0.5756 -0.6376 1301370 TimTec1_005355 Cc1cc(C)cc(c1)N2C(Nc3ccccc3C2=O)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D10 compound treatment 60680.0 -41500.0 -0.68 146200.0 54500.0 0.87 0.1301 0.1176 3086472 TimTec1_005356 N/C(=C\C(=O)c1c(O)c(F)c(F)c(F)c1F)/C(=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D11 compound treatment 13840.0 -88300.0 -1.46 18640.0 -73000.0 -1.16 -1.8542 -0.9938 1471806 TimTec1_005357 Fc1ccc(cc1)N2C(Nc3ccccc3C2=O)c4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D12 compound treatment 82120.0 -20100.0 -0.33 116440.0 24800.0 0.39 0.045 0.0874 3212726 TimTec1_005358 CCCC1=C(C(C(=C(N)O1)C#N)c2ccccc2OC)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D13 compound treatment 7640.0 -94500.0 -1.56 11960.0 -79700.0 -1.27 -2.0019 -0.9948 3086475 TimTec1_005359 Fc1ccc(/C=C/2\CN(Cc3ccccc3)C/C(=C/c4ccc(F)cc4)/C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D14 compound treatment 107520.0 5350.0 0.09 129680.0 38000.0 0.61 0.4907 0.8017 3212727 TimTec1_005360 CN1C(=O)/C(=C\C=C\c2ccccc2Cl)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D15 compound treatment 51400.0 -50800.0 -0.84 92600.0 919.0 0.01 -0.5823 -0.6946 1327468 TimTec1_005361 NC1=C(C#N)C(C2=C(CCCC2=O)N1c3sc4CCCCCc4c3C#N)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D16 compound treatment 57040.0 -45100.0 -0.74 128080.0 36400.0 0.58 -0.1166 -0.1235 1533582 TimTec1_005362 CCCn1c2ccccc2c3nnc(SCN4C(=O)c5ccccc5C4=O)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D17 compound treatment 62480.0 -39700.0 -0.66 118440.0 26800.0 0.43 -0.1617 -0.2069 1465950 TimTec1_005363 CCC(Sc1nnc2c3ccccc3n(C)c2n1)C(=O)Nc4ccc(cc4)S(=O)(=O)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D18 compound treatment 61600.0 -40600.0 -0.67 114640.0 23000.0 0.37 -0.2148 -0.2815 1384915 TimTec1_005364 Clc1cccc(NC(=O)COC(=O)c2ccc(cc2)N3C(=O)CCC3=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D19 compound treatment 87160.0 -15000.0 -0.25 176920.0 85200.0 1.36 0.7854 0.5688 1450022 TimTec1_005365 COc1ccc2N(Cn3nc(COc4ccccc4)n(C)c3=S)CCCc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D20 compound treatment 93160.0 -9010.0 -0.15 167360.0 75700.0 1.21 0.7477 0.6152 1291038 TimTec1_005366 CCC(O)C#CCN1CCN(C)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D21 compound treatment 51240.0 -50900.0 -0.84 64120.0 -27600.0 -0.44 -0.9051 -0.9542 1912707 TimTec1_005367 CC(C)(O)C(=O)/C=C/c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D22 compound treatment 66080.0 -36100.0 -0.6 99800.0 8120.0 0.13 -0.3298 -0.5409 1025952 TimTec1_005368 Cc1cc(Cc2ccc(N)c(C)c2)ccc1N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D23 mock treatment 69360.0 -32800.0 -0.54 147360.0 55700.0 0.89 0.2445 0.2352 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 D24 mock treatment 54640.0 -47500.0 -0.78 85400.0 -6280.0 -0.1 -0.6256 -0.7909 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E01 compound treatment 81800.0 -20400.0 -0.34 113080.0 21400.0 0.34 0.0034 0.0071 2102259 TimTec1_005369 CC(C)CC(NCc1c(O)ccc2c(C)cc(=O)oc12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E02 compound treatment 85000.0 -17200.0 -0.28 86200.0 -5480.0 -0.09 -0.2622 -0.884 3086481 TimTec1_005370 O=C1NC(=O)/C(=C\c2ccccc2)/N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E03 compound treatment 55240.0 -46900.0 -0.77 77600.0 -14100.0 -0.22 -0.7065 -0.8759 1012035 TimTec1_005371 CN1CCC(O)(C(C1)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E04 compound treatment 83440.0 -18700.0 -0.31 106280.0 14600.0 0.23 -0.0541 -0.1398 3212728 TimTec1_005372 CCc1ccc(cc1)C2C(=C(N)OC3=C2C(=O)CCC3)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E05 compound treatment 95440.0 -6730.0 -0.11 119760.0 28100.0 0.45 0.2379 0.5159 1629849 TimTec1_005373 CC(C)CN(CC(C)C)C(=O)CCN1C(=O)c2ccccc2C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E06 compound treatment 79800.0 -22400.0 -0.37 105480.0 13800.0 0.22 -0.1056 -0.2457 3212729 TimTec1_005374 CSc1nc2sc3COC(C)(C)Cc3c2c(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E07 compound treatment 6400.0 -95800.0 -1.58 9680.0 -82000.0 -1.31 -2.0421 -0.9955 3212730 TimTec1_005375 CC(C)c1ccc(C)cc1OC(=O)NC2(Oc3ccc(Cl)cc3O2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E08 compound treatment 66320.0 -35900.0 -0.59 127400.0 35700.0 0.57 -0.0159 -0.0194 1308284 TimTec1_005376 Cc1ccc(cc1)N2CC(=O)SC32CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E09 compound treatment 77120.0 -25100.0 -0.41 105680.0 14000.0 0.22 -0.1346 -0.2865 3085473 TimTec1_005377 COc1ccc(cc1)C2=CN3C(=O)CSC3=NN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E10 compound treatment 72640.0 -29500.0 -0.49 118600.0 26900.0 0.43 -0.0413 -0.0636 1639246 TimTec1_005378 CCOC(=O)c1c(CN2CCOCC2)oc3ccc(OC)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E11 compound treatment 95200.0 -6970.0 -0.12 113120.0 21400.0 0.34 0.1602 0.4444 3085475 TimTec1_005379 CC(=C)Cn1c(S)nc2ccccc2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E12 compound treatment 24320.0 -77900.0 -1.29 31000.0 -60700.0 -0.97 -1.5926 -0.9902 3212731 TimTec1_005380 Cc1ccc(/C=C/2\OC(=O)C=C2)o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E13 compound treatment 94960.0 -7210.0 -0.12 117120.0 25400.0 0.41 0.2025 0.4793 1303286 TimTec1_005381 CCc1cc2c(=O)c(coc2cc1O)c3nc(C)cs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E14 compound treatment 8000.0 -94200.0 -1.55 13120.0 -78600.0 -1.25 -1.9846 -0.9942 3085477 TimTec1_005382 O=C(CSc1nc(ccc1C#N)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E15 compound treatment 89920.0 -12300.0 -0.2 124280.0 32600.0 0.52 0.2244 0.4025 3212732 TimTec1_005383 COc1ccccc1N2CCN(CC2)/N=C/c3sccc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E16 compound treatment 80840.0 -21300.0 -0.35 117320.0 25600.0 0.41 0.04 0.0741 1527733 TimTec1_005384 Nc1nonc1C(=O)NCc2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E17 compound treatment 8240.0 -93900.0 -1.55 11360.0 -80300.0 -1.28 -2.0016 -0.9955 3212733 TimTec1_005385 O=C1N([C@H]2CC(=O)[C@@H]3OCC2O3)S(=O)(=O)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E18 compound treatment 82520.0 -19700.0 -0.32 125760.0 34100.0 0.54 0.1547 0.2445 1204206 TimTec1_005386 CC(C)(C)NC(=O)CSc1nsc(SCC(=O)NC(C)(C)C)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E19 compound treatment 32440.0 -69700.0 -1.15 38840.0 -52800.0 -0.84 -1.4095 -0.9882 3212734 TimTec1_005387 NC1=C(C#N)C(C(=c2s/c(=C\c3ccco3)/c(=O)n12)C#N)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E20 compound treatment 87240.0 -14900.0 -0.25 99360.0 7680.0 0.12 -0.0877 -0.3188 1594563 TimTec1_005388 OC(=O)CCC(=O)Nc1ccccc1C#Cc2ccc(Br)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E21 compound treatment 76160.0 -26000.0 -0.43 84440.0 -7240.0 -0.12 -0.3852 -0.8664 3212735 TimTec1_005389 COc1cccc(/C=N/c2ccc(cc2)c3nc4ccc(C)cc4o3)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E22 compound treatment 68240.0 -33900.0 -0.56 88840.0 -2840.0 -0.05 -0.4281 -0.7618 3085483 TimTec1_005390 C/C=C/c1c(C)nc2sc(C#N)c(N)c2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E23 mock treatment 89040.0 -13100.0 -0.22 97080.0 5400.0 0.09 -0.0924 -0.3963 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 E24 mock treatment 71560.0 -30600.0 -0.51 105120.0 13400.0 0.21 -0.2058 -0.3751 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F01 compound treatment 55800.0 -46400.0 -0.77 77560.0 -14100.0 -0.23 -0.7004 -0.8779 1199396 TimTec1_005391 O=C(NCc1cccs1)c2cccc(c2)S(=O)(=O)N3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F02 compound treatment 58480.0 -43700.0 -0.72 61000.0 -30700.0 -0.49 -0.8558 -0.9821 1438185 TimTec1_005392 N#Cc1ccc(cc1C#N)n2c(nnc2c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F03 compound treatment 115600.0 13400.0 0.22 135000.0 43300.0 0.69 0.645 0.8894 1602974 TimTec1_005393 Cc1cc(C)c2oc(nc2c1)c3ccc(N)cc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F04 compound treatment 87440.0 -14700.0 -0.24 118440.0 26800.0 0.43 0.1296 0.264 1565318 TimTec1_005394 COC(=O)C(C(Nc1ccccc1)c2ccccc2)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F05 compound treatment 80360.0 -21800.0 -0.36 99600.0 7920.0 0.13 -0.1653 -0.4334 3085487 TimTec1_005395 COC(=O)CSc1nc(C)nc2c3ccccc3oc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F06 compound treatment 118000.0 15800.0 0.26 123720.0 32000.0 0.51 0.5458 0.9516 3212736 TimTec1_005396 CN(C)c1ccc(/C=N/c2ccc3[nH]c(=O)[nH]c3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F07 compound treatment 93120.0 -9050.0 -0.15 112640.0 21000.0 0.33 0.1306 0.3568 3085489 TimTec1_005397 CN(C)C(=O)/C(=C/c1ccc(F)cc1)/NC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F08 compound treatment 17160.0 -85000.0 -1.4 25600.0 -66100.0 -1.05 -1.737 -0.99 3212737 TimTec1_005398 N#Cc1c(NCSCc2ccccc2)sc3CCCCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F09 compound treatment 6800.0 -95400.0 -1.57 9080.0 -82600.0 -1.32 -2.0441 -0.996 1212031 TimTec1_005399 CC(C)(C)C(=O)Nc1cc(NC(=O)C(C)(C)C)cc(c1)C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F10 compound treatment 99760.0 -2410.0 -0.04 123680.0 32000.0 0.51 0.3325 0.6499 1476455 TimTec1_005400 CC(CS(=O)(=O)c1ccccc1)N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F11 compound treatment 6480.0 -95700.0 -1.58 8600.0 -83100.0 -1.32 -2.0533 -0.9962 1295263 TimTec1_005401 Cc1ccc(cc1)S(=O)(=O)Nc2ccc(cc2)c3nc4ccccc4o3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F12 compound treatment 15160.0 -87000.0 -1.44 28320.0 -63400.0 -1.01 -1.7297 -0.9851 1158028 TimTec1_005402 C(Sc1nnc2c3ccccc3n(Cc4ccccc4)c2n1)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F13 compound treatment 118160.0 16000.0 0.26 117560.0 25900.0 0.41 0.4783 0.9767 3086060 TimTec1_005403 CCC(NC(=O)OC1CCCCC1C)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F14 compound treatment 67720.0 -34500.0 -0.57 71440.0 -20200.0 -0.32 -0.6303 -0.9639 3212738 TimTec1_005404 CN1C(=O)S/C(=C/c2cc(C)n(c2C)c3ccccc3)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F15 compound treatment 7920.0 -94300.0 -1.56 9120.0 -82600.0 -1.32 -2.0306 -0.9965 1322720 TimTec1_005405 CCOC(=O)c1c(CSc2ccccc2)oc3ccc(O)c(CN(C)C)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F16 compound treatment 63360.0 -38800.0 -0.64 72560.0 -19100.0 -0.3 -0.6685 -0.9423 1183235 TimTec1_005406 Cc1ccc2nc(NC(=O)C(Cc3ccccc3)NC(=O)OCc4ccccc4)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F17 compound treatment 102120.0 -51.3 0.0 132680.0 41000.0 0.65 0.4615 0.7062 1662436 TimTec1_005407 Nc1nonc1n2nnc(C(=O)N3CCCC3)c2c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F18 compound treatment 110960.0 8790.0 0.15 125800.0 34100.0 0.54 0.4871 0.8655 1606341 TimTec1_005408 COC(=O)C1=C(c2ccccc2)S(=O)(=O)CCN1C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F19 compound treatment 87600.0 -14600.0 -0.24 104320.0 12600.0 0.2 -0.0276 -0.0881 1282067 TimTec1_005409 COC(=O)c1ccc(NC(=O)CSc2nnc(N)s2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F20 compound treatment 90440.0 -11700.0 -0.19 123720.0 32000.0 0.51 0.2242 0.4104 3086064 TimTec1_005410 CSC1=NC(C)(C)Cc2c(C)cccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F21 compound treatment 111400.0 9230.0 0.15 121800.0 30100.0 0.48 0.4472 0.8879 1037267 TimTec1_005411 CC(=O)Nc1ccc(cc1)S(=O)(=O)N2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F22 compound treatment 52720.0 -49500.0 -0.82 77040.0 -14600.0 -0.23 -0.7422 -0.8742 1160915 TimTec1_005412 Cc1cccc(c1C)n2c(CSc3nc4ccccc4[nH]3)nc5ccccc5c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F23 mock treatment 75480.0 -26700.0 -0.44 99800.0 8120.0 0.13 -0.2201 -0.4792 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 F24 mock treatment 60960.0 -41200.0 -0.68 102600.0 10900.0 0.17 -0.358 -0.5098 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G01 compound treatment 100000.0 -2170.0 -0.04 95920.0 4240.0 0.07 0.0224 0.2933 3086066 TimTec1_005413 CCC(C)C(NCc1c(O)ccc2c(C)cc(=O)oc12)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G02 compound treatment 81280.0 -20900.0 -0.34 84560.0 -7120.0 -0.11 -0.3241 -0.8927 3212809 TimTec1_005414 COC(=O)n1c(SC)nc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G03 compound treatment 100920.0 -1250.0 -0.02 90000.0 -1680.0 -0.03 -0.0336 -0.9917 1428822 TimTec1_005415 CC(C)c1ccccc1NC(=O)CN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G04 compound treatment 69760.0 -32400.0 -0.54 72600.0 -19100.0 -0.3 -0.5934 -0.9642 1673731 TimTec1_005416 C=CCN(CC=C)C(=S)Oc1ccc(cc1)C(=O)Nc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G05 compound treatment 92720.0 -9450.0 -0.16 101040.0 9360.0 0.15 -0.0048 -0.0224 3212810 TimTec1_005417 NNC(=O)c1cc(nn1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G06 compound treatment 108600.0 6430.0 0.11 109360.0 17700.0 0.28 0.2743 0.911 3086070 TimTec1_005418 COC(=O)Nc1ccc(Br)cn1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G07 compound treatment 94280.0 -7890.0 -0.13 104040.0 12400.0 0.2 0.0472 0.1998 3212811 TimTec1_005419 CN/1N(C(=NC(=O)\C1=C/c2ccc(O)cc2)C)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G08 compound treatment 51160.0 -51000.0 -0.84 51920.0 -39800.0 -0.63 -1.0435 -0.9902 1496851 TimTec1_005420 CCSc1nc2-c3ccccc3CC4(CCCCC4)c2c(=O)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G09 compound treatment 98600.0 -3570.0 -0.06 105960.0 14300.0 0.23 0.1192 0.5072 3212812 TimTec1_005421 CC1SC2=NNC(=CN2C1=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G10 compound treatment 93400.0 -8770.0 -0.14 106200.0 14500.0 0.23 0.0612 0.2244 1578108 TimTec1_005422 CC(=O)Oc1ccc(cc1)c2nc3ccccc3c(=O)o2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G11 compound treatment 33440.0 -68700.0 -1.13 62360.0 -29300.0 -0.47 -1.1327 -0.9231 1637150 TimTec1_005423 Cc1ccc(cc1)S(=O)(=O)NCCC(=O)Oc2cc3oc(=O)c4CCCCc4c3cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G12 compound treatment 68280.0 -33900.0 -0.56 80640.0 -11000.0 -0.18 -0.52 -0.8867 1014256 TimTec1_005424 c1c([nH]c2ccccc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G13 compound treatment 98440.0 -3730.0 -0.06 130600.0 38900.0 0.62 0.3951 0.6338 1442327 TimTec1_005425 CCc1cc(C(=O)Cc2nc(C)cs2)c(O)cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G14 compound treatment 107480.0 5310.0 0.09 113760.0 22100.0 0.35 0.3108 0.857 3212813 TimTec1_005426 CCOc1cc(/C=N/CCN2Cc3ccccc3C2=O)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G15 compound treatment 105840.0 3670.0 0.06 117800.0 26100.0 0.42 0.3372 0.8015 3086140 TimTec1_005427 COc1ccc(/C=N/S(=O)(=O)c2ccccc2)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G16 compound treatment 84760.0 -17400.0 -0.29 121440.0 29800.0 0.47 0.1322 0.2383 3212814 TimTec1_005428 Clc1ccc(NC(=O)CSC(=O)c2ccccc2)nc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G17 compound treatment 19640.0 -82500.0 -1.36 21040.0 -70600.0 -1.13 -1.7595 -0.9955 3086142 TimTec1_005429 Oc1n[n+](no1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G18 compound treatment 95800.0 -6370.0 -0.11 111760.0 20100.0 0.32 0.1519 0.451 3212815 TimTec1_005430 COc1cc(/C=N/c2oc(C)c(C)c2C#N)cc(Br)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G19 compound treatment 99920.0 -2250.0 -0.04 97840.0 6160.0 0.1 0.0431 0.4109 1400147 TimTec1_005431 Cc1ccccc1OCC(=O)Nc2cc(Sc3ccccn3)cc(c2)S(=O)(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G20 compound treatment 103040.0 869.0 0.01 109760.0 18100.0 0.29 0.2139 0.7414 3086144 TimTec1_005432 C(=N/c1nnc2[nH]cnn12)\c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G21 compound treatment 96360.0 -5810.0 -0.1 107960.0 16300.0 0.26 0.1156 0.418 1704603 TimTec1_005433 CCN(CC)C(=O)N1CCc2ccccc2C1CN3C(=O)c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G22 compound treatment 91640.0 -10500.0 -0.17 108640.0 17000.0 0.27 0.0682 0.2122 3212816 TimTec1_005434 CCc1c(C)[nH]c(=S)c(C#N)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G23 mock treatment 94760.0 -7410.0 -0.12 95840.0 4160.0 0.07 -0.0396 -0.2849 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 G24 mock treatment 89000.0 -13200.0 -0.22 88800.0 -2880.0 -0.05 -0.1862 -0.838 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H01 compound treatment 81720.0 -20500.0 -0.34 88440.0 -3240.0 -0.05 -0.2752 -0.8059 1451425 TimTec1_005435 CCN(CC)S(=O)(=O)c1cccc(c1)C(=O)Nc2nncs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H02 compound treatment 41080.0 -61100.0 -1.01 38440.0 -53200.0 -0.85 -1.3131 -0.9963 3086147 TimTec1_005436 COc1cc(/C=C\2/S\C(=N/c3ccccc3)\N(N(C)C)C2=O)cc(Br)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H03 compound treatment 78240.0 -23900.0 -0.4 78680.0 -13000.0 -0.21 -0.4259 -0.9547 3212817 TimTec1_005437 Cc1cc-2c(cn1)/C(=N\c3ccccc3C)/c4ccccc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H04 compound treatment 25080.0 -77100.0 -1.27 26400.0 -65300.0 -1.04 -1.6356 -0.995 3086149 TimTec1_005438 Clc1ss/c(=N\c2ccccn2)/c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H05 compound treatment 57520.0 -44700.0 -0.74 60600.0 -31100.0 -0.5 -0.8715 -0.9813 1471924 TimTec1_005439 COC(=O)c1ccc2c(c1)sc3nc(cn32)c4ccc(OC)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H06 compound treatment 111800.0 9630.0 0.16 108800.0 17100.0 0.27 0.3053 0.9669 3212818 TimTec1_005440 Cc1ccc(/N=C/c2ccc3OCOc3c2)c(Br)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H07 compound treatment 89800.0 -12400.0 -0.2 91600.0 -81.3 0.0 -0.1453 -0.7116 1713930 TimTec1_005441 CC(C)C(O)(C#CCN1CCCCC1)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H08 compound treatment 109880.0 7710.0 0.13 120160.0 28500.0 0.45 0.4109 0.8717 3212819 TimTec1_005442 CC(=O)NC1=NC(=O)/C(=C\c2ccc(Cl)cc2)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H09 compound treatment 111080.0 8910.0 0.15 106480.0 14800.0 0.24 0.2708 0.9741 1216409 TimTec1_005443 Nc1nnc(SCC(=O)NCc2ccco2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H10 compound treatment 9880.0 -92300.0 -1.52 15200.0 -76500.0 -1.22 -1.9392 -0.9939 3212820 TimTec1_005444 Cc1nc(Sc2ccccc2)c3oc4ccccc4c3n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H11 compound treatment 54840.0 -47300.0 -0.78 86240.0 -5440.0 -0.09 -0.6138 -0.7808 1240888 TimTec1_005445 O=C1CSC2(CCCCC2)N1Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H12 compound treatment 113800.0 11600.0 0.19 116840.0 25200.0 0.4 0.4193 0.9431 3212821 TimTec1_005446 Clc1ccc(NC(=O)CSC2=NCCS2)nc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H13 compound treatment 77160.0 -25000.0 -0.41 75880.0 -15800.0 -0.25 -0.47 -0.9719 3212822 TimTec1_005447 COC(=O)C1=C(N)N(C2=C(C1c3ccccc3)C(=O)CCC2)c4cccc(c4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H14 compound treatment 33200.0 -69000.0 -1.14 33400.0 -58300.0 -0.93 -1.4619 -0.9949 1666111 TimTec1_005448 Oc1ccccc1N=c2c(=O)c3ccccc3c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H15 compound treatment 114640.0 12500.0 0.21 117280.0 25600.0 0.41 0.434 0.9498 3086218 TimTec1_005449 O=C(NC1CC1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H16 compound treatment 109160.0 6990.0 0.12 99080.0 7400.0 0.12 0.165 0.9999 1687122 TimTec1_005450 COc1ccc(cc1)C2CC3(OCCO3)C4(CCCCC4)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H17 compound treatment 84800.0 -17400.0 -0.29 79560.0 -12100.0 -0.19 -0.3394 -0.9815 3212823 TimTec1_005451 Clc1cccc(/C=C\2/SC(=NC2=O)N3CCCC3)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H18 compound treatment 111800.0 9630.0 0.16 111960.0 20300.0 0.32 0.3409 0.9466 1549014 TimTec1_005452 O=C(CSc1nnc2c3ccccc3[nH]c2n1)NCc4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H19 compound treatment 88520.0 -13700.0 -0.23 84320.0 -7360.0 -0.12 -0.2423 -0.9537 1530955 TimTec1_005453 COC(=O)C1=C(N)N(C2=C(C1c3ccccc3)C(=O)CC(C)(C)C2)c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H20 compound treatment 92800.0 -9370.0 -0.15 85440.0 -6240.0 -0.1 -0.1797 -0.9772 1138726 TimTec1_005454 CCOC(=O)c1ccccc1NCn2c(=S)oc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H21 compound treatment 105400.0 3230.0 0.05 108640.0 17000.0 0.27 0.2288 0.8305 1258567 TimTec1_005455 OC(=O)c1ccc2C(=O)N(C(=O)c2c1)c3cccc(c3)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H22 compound treatment 64160.0 -38000.0 -0.63 74040.0 -17600.0 -0.28 -0.6425 -0.9344 1345011 TimTec1_005456 OC(=O)c1ccccc1NC(=O)c2cc(ccc2Cl)S(=O)(=O)N3CCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H23 mock treatment 111280.0 9110.0 0.15 130840.0 39200.0 0.62 0.5476 0.8531 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 H24 mock treatment 84600.0 -17600.0 -0.29 72920.0 -18800.0 -0.3 -0.4165 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I01 compound treatment 36840.0 -65300.0 -1.08 28480.0 -63200.0 -1.01 -1.4749 -0.9994 1452955 TimTec1_005457 CCOC(=O)c1c(oc2ccc(OCC)cc12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I02 compound treatment 31320.0 -70900.0 -1.17 12800.0 -78900.0 -1.26 -1.716 -0.9993 1419694 TimTec1_005458 CCCc1ccc2c(N)c(sc2n1)C(=O)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I03 compound treatment 90640.0 -11500.0 -0.19 72280.0 -19400.0 -0.31 -0.3533 -0.9728 1348330 TimTec1_005459 CCc1ccc(OC(=O)CN2C(=O)c3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I04 compound treatment 107360.0 5190.0 0.09 89880.0 -1800.0 -0.03 0.0403 0.4457 1011570 TimTec1_005460 COc1ccc2oc(=O)cc(C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I05 compound treatment 70800.0 -31400.0 -0.52 67920.0 -23800.0 -0.38 -0.634 -0.9882 1591902 TimTec1_005461 NNC(=O)Cc1nc2ccccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I06 compound treatment 30680.0 -71500.0 -1.18 27720.0 -64000.0 -1.02 -1.5553 -0.9973 3086226 TimTec1_005462 CCCC(=O)n1c(=S)oc2cc(Cl)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I07 compound treatment 120000.0 17800.0 0.29 96240.0 4560.0 0.07 0.2595 0.856 3212824 TimTec1_005463 Cc1ccc(cc1)C(=O)/N=c\2/n(C)n(c(C)nc2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I08 compound treatment 92880.0 -9290.0 -0.15 76760.0 -14900.0 -0.24 -0.2766 -0.9775 1332287 TimTec1_005464 NC(=O)CN(c1ccc(Cl)cc1Cl)S(=O)(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I09 compound treatment 19160.0 -83000.0 -1.37 22000.0 -69700.0 -1.11 -1.7543 -0.9946 1228160 TimTec1_005465 O=C(SCc1nc2ccccc2[nH]1)c3ccc(cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I10 compound treatment 50160.0 -52000.0 -0.86 90440.0 -1240.0 -0.02 -0.6211 -0.7232 3212825 TimTec1_005466 Cc1ccc2cc3/C(=N\C4CCCCC4)/c5ccccc5-c3nc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I11 compound treatment 109720.0 7550.0 0.12 112400.0 20700.0 0.33 0.3216 0.9112 3086229 TimTec1_005467 Cc1ccc2nc(NCc3ccccc3)c(/C=N/c4ccc(Cl)cc4)c(=O)n2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I12 compound treatment 75200.0 -27000.0 -0.45 73840.0 -17800.0 -0.28 -0.5159 -0.9765 3212826 TimTec1_005468 COc1ccc(/N=C\2/c3ccccc3-c4nc5ccccc5nc24)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I13 compound treatment 78640.0 -23500.0 -0.39 87520.0 -4160.0 -0.07 -0.3216 -0.816 1582817 TimTec1_005469 CN(C)Cc1c(C)cc2oc(=O)c3CCCCc3c2c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I14 compound treatment 91120.0 -11100.0 -0.18 91400.0 -281.0 0.0 -0.1322 -0.7243 3086232 TimTec1_005470 CCc1ccc(cc1)c2nn(c3ccccc3)c(=S)c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I15 compound treatment 112960.0 10800.0 0.18 99040.0 7360.0 0.12 0.2089 0.9795 3212903 TimTec1_005471 CN(C)c1ccc(/C=N/S(=O)(=O)c2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I16 compound treatment 113960.0 11800.0 0.19 95200.0 3520.0 0.06 0.1773 0.8753 1444311 TimTec1_005472 COC(=O)c1ccc(OC(=O)COC(=O)CN2C(=O)c3ccccc3C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I17 compound treatment 30120.0 -72100.0 -1.19 28920.0 -62800.0 -1.0 -1.5483 -0.9963 3212904 TimTec1_005473 CSc1c(CC(=O)Nc2ccccc2)n(Cc3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I18 compound treatment 106680.0 4510.0 0.07 109800.0 18100.0 0.29 0.2568 0.8612 3086235 TimTec1_005474 Fc1ccc(/C=N/c2nnc3[nH]cnn23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I19 compound treatment 42560.0 -59600.0 -0.98 31960.0 -59700.0 -0.95 -1.3689 -0.9999 3212905 TimTec1_005475 CC(C)(C)c1ccc(cc1)c2nc3ccccc3s2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I20 compound treatment 108600.0 6430.0 0.11 113080.0 21400.0 0.34 0.3162 0.8853 3086300 TimTec1_005476 CCC1(C)OC(=O)N(C1=C)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I21 compound treatment 90880.0 -11300.0 -0.19 91240.0 -441.0 -0.01 -0.1368 -0.7333 3086302 TimTec1_005477 COCc1cc(C)nc2snc(Br)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I22 compound treatment 100880.0 -1290.0 -0.02 109880.0 18200.0 0.29 0.19 0.6534 3212906 TimTec1_005478 Cc1cc(C)c2c(N)c(sc2n1)C(=O)OC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I23 mock treatment 141760.0 39600.0 0.65 102600.0 10900.0 0.17 0.5852 0.8653 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 I24 mock treatment 81840.0 -20300.0 -0.34 77360.0 -14300.0 -0.23 -0.3987 -0.9824 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J01 compound treatment 80880.0 -21300.0 -0.35 48040.0 -43600.0 -0.7 -0.7404 -0.95 1654696 TimTec1_005479 CC(C)C1N(CCN1S(=O)(=O)c2ccc(C)cc2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J02 compound treatment 87600.0 -14600.0 -0.24 64840.0 -26800.0 -0.43 -0.4726 -0.9629 3086304 TimTec1_005480 FC(F)(F)COc1nc(nc(n1)N2CCN(CC2)c3ccccc3)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J03 compound treatment 94600.0 -7570.0 -0.12 70960.0 -20700.0 -0.33 -0.3219 -0.9116 1724083 TimTec1_005481 NC1=C(C#N)C(C2=C(CCCC2=O)N1c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J04 compound treatment 90680.0 -11500.0 -0.19 75720.0 -16000.0 -0.25 -0.314 -0.9895 3086306 TimTec1_005482 CCCCc1c(C)c2ccc(OCC=C)cc2oc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J05 compound treatment 7160.0 -95000.0 -1.57 5640.0 -86000.0 -1.37 -2.0787 -0.9978 3212907 TimTec1_005483 COC(=O)CSC1=NC(=O)/C(=C/c2ccc(OC)cc2)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J06 compound treatment 51120.0 -51100.0 -0.84 39400.0 -52300.0 -0.83 -1.1851 -1.0 3086308 TimTec1_005484 Brc1cc2OCOc2cc1/C=N/c3c(nc4ccccn34)c5ccco5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J07 compound treatment 18720.0 -83500.0 -1.38 7920.0 -83800.0 -1.34 -1.9181 -0.9999 3212908 TimTec1_005485 Clc1ccc(Oc2ccc(/N=C/c3ccc(I)o3)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J08 compound treatment 115080.0 12900.0 0.21 87040.0 -4640.0 -0.07 0.0984 0.4361 3212909 TimTec1_005486 CC(=O)NC1=NC(=O)/C(=C\c2ccc(C)cc2)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J09 compound treatment 69840.0 -32300.0 -0.53 58600.0 -33100.0 -0.53 -0.7502 -1.0 3086311 TimTec1_005487 CCn1c2ccccc2c3cc(/C=N/c4ccc(Cl)cc4)ccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J10 compound treatment 77200.0 -25000.0 -0.41 82400.0 -9280.0 -0.15 -0.3961 -0.9044 1618704 TimTec1_005488 Cc1cc(=O)oc2c(C)c(O)c(CC=C)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J11 compound treatment 115600.0 13400.0 0.22 111560.0 19900.0 0.32 0.3808 0.9847 1654232 TimTec1_005489 CN(CP(=O)(O)CN1CCOCC1)S(=O)(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J12 compound treatment 105800.0 3630.0 0.06 103000.0 11300.0 0.18 0.1699 0.8939 3212910 TimTec1_005490 Clc1ccc(cc1)N2C(=C)C3(CCCCC3)OC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J13 compound treatment 96800.0 -5370.0 -0.09 88200.0 -3480.0 -0.06 -0.1019 -0.9745 3212911 TimTec1_005491 OCCn/1c(cs\c1=N/c2ccccc2)c3cccc(c3)N4C(=O)c5ccccc5C4=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J14 compound treatment 9120.0 -93100.0 -1.54 8480.0 -83200.0 -1.33 -2.0238 -0.9973 3086315 TimTec1_005492 OCCn/1c(cs\c1=N/c2cccc(c2)C(F)(F)F)c3ccc(cc3)S(=O)(=O)N4CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J15 compound treatment 109720.0 7550.0 0.12 88240.0 -3440.0 -0.05 0.0493 0.3623 1655602 TimTec1_005493 CCOC(=O)C(Cc1ccc(NC(=O)c2ccccc2)cc1)N3C(=O)c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J16 compound treatment 123120.0 20900.0 0.35 95560.0 3880.0 0.06 0.2882 0.8205 1386199 TimTec1_005494 CC1(C)OC(=O)N(CCCC(=O)O)C1(C)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J17 compound treatment 27000.0 -75200.0 -1.24 14640.0 -77000.0 -1.23 -1.7457 -1.0 1068676 TimTec1_005495 Cc1ccc(cc1)S(=O)(=O)C=C(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J18 compound treatment 96840.0 -5330.0 -0.09 73800.0 -17900.0 -0.29 -0.2638 -0.8843 3086318 TimTec1_005496 CCOC(=O)C1=C(NC(=S)NC1c2cccc(OC)c2O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J19 compound treatment 111680.0 9510.0 0.16 96880.0 5200.0 0.08 0.1696 0.9554 1433302 TimTec1_005497 COc1cccc(c1)c2nn(CN3CCCC3)c(=S)n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J20 compound treatment 118800.0 16600.0 0.27 107400.0 15700.0 0.25 0.3713 0.999 3212912 TimTec1_005498 COc1ccc(CN(C2CC(=O)N(C2=O)c3ccccc3)C(=O)/C=C/C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J21 compound treatment 120960.0 18800.0 0.31 95440.0 3760.0 0.06 0.2617 0.8284 3086320 TimTec1_005499 CCOC(=O)c1c(/N=C/c2c(O)ccc3ccccc23)sc4CCCc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J22 compound treatment 103440.0 1270.0 0.02 71640.0 -20000.0 -0.32 -0.2111 -0.6593 3212913 TimTec1_005500 CCOc1cc(/C=c/2\sc3nc4c(C)c(C)ccc4n3c2=O)cc(Cl)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J23 mock treatment 124960.0 22800.0 0.38 94680.0 3000.0 0.05 0.2998 0.7906 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 J24 mock treatment 85240.0 -16900.0 -0.28 87160.0 -4520.0 -0.07 -0.2486 -0.8613 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K01 compound treatment 136680.0 34500.0 0.57 45120.0 -46600.0 -0.74 -0.122 -0.1304 1526103 TimTec1_005501 CC(=O)Oc1ccc2oc(c(C(=O)O)c2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K02 compound treatment 94400.0 -7770.0 -0.13 52000.0 -39700.0 -0.63 -0.5379 -0.8336 1186869 TimTec1_005502 COc1ccccc1C(=O)Nc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K03 compound treatment 15080.0 -87100.0 -1.44 9000.0 -82700.0 -1.32 -1.9484 -0.9991 3212914 TimTec1_005503 O=C(NC(=S)NC1CCCC1)/C=C/c2ccc3OCOc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K04 compound treatment 86880.0 -15300.0 -0.25 74280.0 -17400.0 -0.28 -0.3746 -0.9989 3086394 TimTec1_005504 Cc1ccc(cc1)S(=O)(=O)N=C2NCN(CN2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K05 compound treatment 76040.0 -26100.0 -0.43 60520.0 -31200.0 -0.5 -0.6562 -0.9975 1131736 TimTec1_005505 COc1ccc(cc1OC)c2c(C)nn(c2NC(=O)C)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K06 compound treatment 82480.0 -19700.0 -0.33 54480.0 -37200.0 -0.59 -0.6491 -0.96 1007406 TimTec1_005506 COc1ccc(OC(=O)c2ccc(Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K07 compound treatment 100680.0 -1490.0 -0.02 67320.0 -24400.0 -0.39 -0.292 -0.7504 3212915 TimTec1_005507 Clc1ccccc1C(=O)N=C2NCCCCCN2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K08 compound treatment 77160.0 -25000.0 -0.41 39600.0 -52100.0 -0.83 -0.8789 -0.948 1323784 TimTec1_005508 Cc1cccc(c1)S(=O)(=O)N2CCSC2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K09 compound treatment 108280.0 6110.0 0.1 88240.0 -3440.0 -0.05 0.0325 0.2833 1116167 TimTec1_005509 Cn1c(=O)n(C)c2nc(Br)n(CC(=O)c3ccccc3)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K10 compound treatment 91240.0 -10900.0 -0.18 84000.0 -7680.0 -0.12 -0.2142 -0.9821 1464973 TimTec1_005510 OC(=O)c1cc(c2ccccc2)c(cn1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K11 compound treatment 8720.0 -93500.0 -1.54 7600.0 -84100.0 -1.34 -2.0384 -0.9975 3212916 TimTec1_005511 Cc1ccc2nc(Nc3ccc(Cl)cc3)c(/C=N/O)c(=O)n2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K12 compound treatment 48920.0 -53300.0 -0.88 48680.0 -43000.0 -0.69 -1.1062 -0.9924 3086399 TimTec1_005512 Cc1cccc2nc3/C(=N\c4ccccc4)/c5ccccc5-c3nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K13 compound treatment 91320.0 -10900.0 -0.18 74480.0 -17200.0 -0.27 -0.3205 -0.9787 1486848 TimTec1_005513 CCCc1cc2c(=O)c(coc2cc1O)c3nc4ccccc4n3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K14 compound treatment 104520.0 2350.0 0.04 79520.0 -12200.0 -0.19 -0.1096 -0.5547 3086401 TimTec1_005514 CSc1cccc2c(SC)cccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K15 compound treatment 23480.0 -78700.0 -1.3 16280.0 -75400.0 -1.2 -1.7683 -0.9992 3212917 TimTec1_005515 C(N1CCN(CC1)/N=C/c2ccncc2)c3cccc4ccccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K16 compound treatment 77840.0 -24300.0 -0.4 48320.0 -43400.0 -0.69 -0.7727 -0.9667 3086404 TimTec1_005516 O=c1/c(=C/C=C/c2ccccc2)/sc3nc4ccccc4n13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K17 compound treatment 100560.0 -1610.0 -0.03 60000.0 -31700.0 -0.5 -0.3759 -0.7433 1919931 TimTec1_005517 Sc1nnc(o1)C2(CCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K18 compound treatment 98320.0 -3850.0 -0.06 60480.0 -31200.0 -0.5 -0.3966 -0.7911 3212918 TimTec1_005518 Cc1ccc(cc1)C2=C/C(=C/c3c(O)ccc4ccccc34)/C(=O)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K19 compound treatment 108960.0 6790.0 0.11 75800.0 -15900.0 -0.25 -0.0997 -0.3603 3086406 TimTec1_005519 COc1ccc(cc1)N2C(=O)CC(S/C(=N/c3ccccc3)/N)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K20 compound treatment 86520.0 -15700.0 -0.26 84120.0 -7560.0 -0.12 -0.2679 -0.9397 3212919 TimTec1_005520 COc1ccc(OCCNS(=O)(=O)c2ccc3c(c2)oc4ccccc43)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K21 compound treatment 48680.0 -53500.0 -0.88 49400.0 -42300.0 -0.67 -1.1009 -0.9911 3086408 TimTec1_005521 Cc1ccccc1C2C(=C(N)SC(=C2C#N)N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K22 compound treatment 8800.0 -93400.0 -1.54 6080.0 -85600.0 -1.36 -2.0546 -0.9982 3212920 TimTec1_005522 COc1ccc(cc1)C(=O)[C@@H]2[C@@H](c3ccccc3F)C(C#N)(C#N)[C@H]4C=Cc5ccccc5N24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K23 mock treatment 116880.0 14700.0 0.24 92280.0 599.0 0.01 0.1784 0.7343 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 K24 mock treatment 128120.0 25900.0 0.43 65720.0 -26000.0 -0.41 0.0103 0.0173 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L01 compound treatment 88080.0 -14100.0 -0.23 36040.0 -55600.0 -0.89 -0.7916 -0.8634 3212921 TimTec1_005523 Oc1ccc(Br)cc1/C=N/c2ccc3nc(SCC(=O)Nc4ccccc4)sc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L02 compound treatment 91480.0 -10700.0 -0.18 40120.0 -51600.0 -0.82 -0.7059 -0.8398 3086411 TimTec1_005524 Fc1cccc(c1)N2C(=O)/C(=C/C=C/c3ccccc3)/SC2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L03 compound treatment 5600.0 -96600.0 -1.59 3520.0 -88200.0 -1.41 -2.1208 -0.998 3086413 TimTec1_005525 NC1=C(C#N)C(c2ccsc2)c3ccc4ccccc4c3O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L04 compound treatment 12080.0 -90100.0 -1.49 9680.0 -82000.0 -1.31 -1.9758 -0.9979 1682053 TimTec1_005526 Cc1ccc2nc(cn2c1)c3ccc(O)c(O)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L05 compound treatment 57880.0 -44300.0 -0.73 54440.0 -37200.0 -0.59 -0.9367 -0.9947 1536268 TimTec1_005527 Cc1ccc(cc1)N2C(=C(C#N)C(C3=C2CC(C)(C)CC3=O)c4ccccc4)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L06 compound treatment 109000.0 6830.0 0.11 83320.0 -8360.0 -0.13 -0.0145 -0.0832 3211217 TimTec1_005528 CC1(C)NN1CCCN2NC2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L07 compound treatment 54800.0 -47400.0 -0.78 46720.0 -45000.0 -0.72 -1.0597 -0.9991 1273515 TimTec1_005529 OC(=O)c1cc(Cl)c(Cl)cc1C(=O)Nc2ccc(Oc3ccccc3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L08 compound treatment 89440.0 -12700.0 -0.21 61600.0 -30100.0 -0.48 -0.4876 -0.9315 1548568 TimTec1_005530 C=CCNC(=O)C1CC1(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L09 compound treatment 43360.0 -58800.0 -0.97 27480.0 -64200.0 -1.02 -1.41 -0.9997 3211218 TimTec1_005531 Cc1ccc2nc(sc2c1)c3ccc(/N=C\c4ccc[nH]4)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L10 compound treatment 115800.0 13600.0 0.22 91080.0 -601.0 -0.01 0.1523 0.6764 1209920 TimTec1_005532 OCN1C(C(=C(O)C1=O)C(=O)c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L11 compound treatment 100080.0 -2090.0 -0.03 93680.0 2000.0 0.03 -0.0019 -0.0401 1148781 TimTec1_005533 CCN(CC)C(=O)c1ccc(o1)C(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L12 compound treatment 8560.0 -93600.0 -1.55 7840.0 -83800.0 -1.34 -2.0376 -0.9974 3211219 TimTec1_005534 CCc1c(C)[nH]c(C(=O)OCc2ccccc2)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L13 compound treatment 107840.0 5670.0 0.09 99840.0 8160.0 0.13 0.1581 0.987 1175161 TimTec1_005535 O=P(CCN1CCOCC1)(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L14 compound treatment 113560.0 11400.0 0.19 92160.0 479.0 0.01 0.1383 0.7352 3086492 TimTec1_005536 OC(=O)c1ccc(/N=C/c2ccc(OC(=O)c3sc4ccccc4c3Cl)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L15 compound treatment 104280.0 2110.0 0.03 51880.0 -39800.0 -0.63 -0.424 -0.6673 3211220 TimTec1_005537 CCOC(=O)CC1=C(C#N)C(C(=C(N)O1)C(=O)OCC)c2cccnc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L16 compound treatment 8920.0 -93300.0 -1.54 5200.0 -86500.0 -1.38 -2.0631 -0.9985 1174009 TimTec1_005538 CCCSc1nnc2c3ccccc3n(Cc4ccccc4)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L17 compound treatment 59000.0 -43200.0 -0.71 33000.0 -58700.0 -0.94 -1.1653 -0.991 3211221 TimTec1_005539 COc1cc(/C=C/2\S/C(=N\c3ccccc3)/N(C2=O)c4ccccc4)cc(OC)c1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L18 compound treatment 111160.0 8990.0 0.15 63000.0 -28700.0 -0.46 -0.2183 -0.4543 3211222 TimTec1_005540 CC(=O)N1c2ccccc2C3=NNC(=S)NC13O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L19 compound treatment 115400.0 13200.0 0.22 94120.0 2440.0 0.04 0.1819 0.8201 3086496 TimTec1_005541 COc1cc(/C=N/c2ccc(\N=C\c3ccc(OC(=O)C)c(OC)c3)cc2)ccc1OC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L20 compound treatment 56400.0 -45800.0 -0.76 38960.0 -52700.0 -0.84 -1.1284 -0.9986 3211223 TimTec1_005542 O=C/1N(C2CCCC2)/C(=N\c3ccccc3)/S\C1=C\c4c[nH]c5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L21 compound treatment 61960.0 -40200.0 -0.66 44440.0 -47200.0 -0.75 -1.0018 -0.998 1270230 TimTec1_005543 COC(=O)C1=C(N)N(C2=C(C1c3ccc(OC)cc3)C(=O)CCC2)c4ccc(C)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L22 compound treatment 95040.0 -7130.0 -0.12 66520.0 -25200.0 -0.4 -0.3668 -0.8776 3086498 TimTec1_005544 CC(C)/C=N/N1C(C(C)C)C(C#N)(C#N)C(=C1N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L23 mock treatment 126200.0 24000.0 0.4 92640.0 959.0 0.02 0.2913 0.7338 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 L24 mock treatment 107560.0 5390.0 0.09 59040.0 -32600.0 -0.52 -0.305 -0.5778 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M01 compound treatment 24440.0 -77700.0 -1.28 7120.0 -84600.0 -1.35 -1.8603 -0.9997 1414805 TimTec1_005545 CC(NC(=O)OCc1ccccc1)C(=O)Oc2cc3oc(=O)c(Cl)c(C)c3cc2Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M02 compound treatment 51200.0 -51000.0 -0.84 25080.0 -66600.0 -1.06 -1.3456 -0.9934 3086501 TimTec1_005546 CCOC(=O)C1=C(CSc2nc(CC)c(C)cc2C#N)OC(=C(C#N)C1c3ccc(F)cc3)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M03 compound treatment 93760.0 -8410.0 -0.14 47520.0 -44200.0 -0.7 -0.5959 -0.8306 1514197 TimTec1_005547 Cc1cccc(NCN2C(=O)CSC2=O)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M04 compound treatment 106840.0 4670.0 0.08 82160.0 -9520.0 -0.15 -0.0528 -0.3103 1084346 TimTec1_005548 CCOC(=O)Cc1nc2ccccc2[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M05 compound treatment 7560.0 -94600.0 -1.56 4840.0 -86800.0 -1.38 -2.0831 -0.9982 1367503 TimTec1_005549 CC(C)C(NS(=O)(=O)c1ccc(C)cc1)C(=O)Oc2ccc3c4CCCCc4c(=O)oc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M06 compound treatment 90800.0 -11400.0 -0.19 58440.0 -33200.0 -0.53 -0.5074 -0.9027 1003422 TimTec1_005550 CC(=O)Oc1ccc(cc1)C(=O)c2ccc(OC(=O)C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M07 compound treatment 49080.0 -53100.0 -0.88 23760.0 -67900.0 -1.08 -1.3852 -0.9945 3085493 TimTec1_005551 CC1=C(N(N/C(=N\CC=C)/S1)c2ccc3OCCOc3c2)C(=O)Nc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M08 compound treatment 117640.0 15500.0 0.26 64960.0 -26700.0 -0.43 -0.1206 -0.2429 1442839 TimTec1_005552 OCCN1CCN(CC1)C(=O)Nc2cccc(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M09 compound treatment 109080.0 6910.0 0.11 75920.0 -15800.0 -0.25 -0.097 -0.3516 1468923 TimTec1_005553 CCOC(=O)c1c(N)cc2[nH]c(=S)[nH]c(=O)c2c1c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M10 compound treatment 28800.0 -73400.0 -1.21 16080.0 -75600.0 -1.2 -1.7085 -1.0 3085496 TimTec1_005554 Cc1ccccc1c2nccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M11 compound treatment 112200.0 10000.0 0.17 91800.0 119.0 0.0 0.1184 0.7151 1298715 TimTec1_005555 CCOC(=O)NS(=O)(=O)c1ccc(C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M12 compound treatment 32320.0 -69900.0 -1.15 27600.0 -64100.0 -1.02 -1.5375 -0.9982 3211224 TimTec1_005556 Cc1ccc-2c(c1)/C(=C/c3ccncc3)/c4cc5ccccc5nc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M13 compound treatment 101160.0 -1010.0 -0.02 92960.0 1280.0 0.02 0.0026 0.099 1313295 TimTec1_005557 Cc1c(OCC(=O)OCc2ccccc2)ccc3c4ccccc4c(=O)oc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M14 compound treatment 86720.0 -15500.0 -0.26 71360.0 -20300.0 -0.32 -0.4094 -0.993 1489666 TimTec1_005558 COC(=O)C(C)N(C(=O)c1c(F)cccc1F)c2c(C)cccc2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M15 compound treatment 105040.0 2870.0 0.05 65000.0 -26700.0 -0.43 -0.2672 -0.6245 1632514 TimTec1_005559 Clc1ccccc1N2C(=O)CC(Nc3ccccc3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M16 compound treatment 8400.0 -93800.0 -1.55 4960.0 -86700.0 -1.38 -2.0719 -0.9984 3085499 TimTec1_005560 CCOC(=O)CSC1=NC(=O)/C(=C\c2ccc(Cl)cc2)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M17 compound treatment 107120.0 4950.0 0.08 84720.0 -6960.0 -0.11 -0.0207 -0.1502 3211225 TimTec1_005561 CC1(C)OC(=O)N(Cc2ccccc2)C1=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M18 compound treatment 119720.0 17500.0 0.29 83480.0 -8200.0 -0.13 0.1124 0.3537 1242728 TimTec1_005562 Cc1ccc(NS(=O)(=O)c2ccc(cc2)N3C(=O)c4ccccc4C3=O)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M19 compound treatment 56600.0 -45600.0 -0.75 33520.0 -58200.0 -0.93 -1.1874 -0.9946 1175444 TimTec1_005563 CCOc1ccc2nc(SCc3c[nH]c4ccccc34)sc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M20 compound treatment 114720.0 12500.0 0.21 77720.0 -14000.0 -0.22 -0.0109 -0.0358 1133231 TimTec1_005564 Cc1[nH]c(=O)[nH]c(=O)c1S(=O)(=O)NCc2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M21 compound treatment 110920.0 8750.0 0.14 70680.0 -21000.0 -0.33 -0.1346 -0.3691 3085503 TimTec1_005565 COc1cc(/C=N/c2c(nc3ccccn23)c4ccc(O)c(OC)c4)ccc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M22 compound treatment 55160.0 -47000.0 -0.78 47240.0 -44400.0 -0.71 -1.0496 -0.999 3211226 TimTec1_005566 CC(=O)N1CC=C2[C@H](C1)[C@@H](c3ccc(F)cc3F)C(C#N)(C#N)C(=C2C#N)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M23 mock treatment 159680.0 57500.0 0.95 91120.0 -561.0 -0.01 0.6649 0.7004 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 M24 mock treatment 127640.0 25500.0 0.42 69240.0 -22400.0 -0.36 0.0444 0.0804 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N01 compound treatment 3560.0 -98600.0 -1.63 1920.0 -89800.0 -1.43 -2.1627 -0.9979 2116249 TimTec1_005567 O=C/1NC(=S)N(C(=O)\C1=C\c2c[nH]c3ccccc23)c4cccc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N02 compound treatment 135520.0 33300.0 0.55 68400.0 -23300.0 -0.37 0.1269 0.1911 1630568 TimTec1_005568 CC(=Cc1c(O)nc2ccccn2c1=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N03 compound treatment 82560.0 -19600.0 -0.32 28960.0 -62700.0 -1.0 -0.9358 -0.8906 1455275 TimTec1_005569 CCOC(=O)CCC1(CCC(=O)OCC)c2ccccc2-c3nc4ccccc4cc31 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N04 compound treatment 118400.0 16200.0 0.27 78760.0 -12900.0 -0.21 0.0438 0.1296 1423540 TimTec1_005570 CCNC(=O)C1CN(C(=O)C1)c2ccc(C)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N05 compound treatment 49800.0 -52400.0 -0.86 39440.0 -52200.0 -0.83 -1.2001 -0.9998 3211227 TimTec1_005571 S/C(=C(/C(=O)c1ccccc1)\[n+]2ccccc2)/Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N06 compound treatment 64840.0 -37300.0 -0.62 42560.0 -49100.0 -0.78 -0.9894 -0.993 3085508 TimTec1_005572 CCOC(=O)Cn/1c(cs\c1=N/c2ccc(F)cc2)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N07 compound treatment 116920.0 14700.0 0.24 58160.0 -33500.0 -0.53 -0.2056 -0.3502 3211228 TimTec1_005573 S=c1[nH]nc([nH]1)C2CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N08 compound treatment 93360.0 -8810.0 -0.15 48240.0 -43400.0 -0.69 -0.5924 -0.8374 1670836 TimTec1_005574 COc1ccc2C(=O)C(CCc2c1C)C3(O)C(=O)N(C)c4ccccc43 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N09 compound treatment 41480.0 -60700.0 -1.0 28040.0 -63600.0 -1.01 -1.4257 -1.0 2116264 TimTec1_005575 Cc1[nH]c2ccccc2c1/C=N/c3ccc(\N=C\c4c(C)[nH]c5ccccc45)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N10 compound treatment 103440.0 1270.0 0.02 87800.0 -3880.0 -0.06 -0.0289 -0.443 1703166 TimTec1_005576 Cn1c(SCC(=O)N2CCCCC2)nc3n(C)c(=O)n(C)c(=O)c13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N11 compound treatment 87120.0 -15100.0 -0.25 58880.0 -32800.0 -0.52 -0.5454 -0.9422 3211229 TimTec1_005577 COc1ccc(cc1)n2nc(C#N)c(N)c(C#N)c2=N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N12 compound treatment 129040.0 26900.0 0.44 98160.0 6480.0 0.1 0.3866 0.849 3085531 TimTec1_005578 O=C(Cn1nnc2ccccc12)C3CC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N13 compound treatment 12040.0 -90100.0 -1.49 11320.0 -80400.0 -1.28 -1.9577 -0.9972 1157884 TimTec1_005579 Cc1ccc(cc1C)c2csc(Nc3ccc4OCOc4c3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N14 compound treatment 110040.0 7870.0 0.13 91520.0 -161.0 0.0 0.09 0.693 1380401 TimTec1_005580 CCOc1ccc(cc1)N2C(=O)CC(N(Cc3ccc(Cl)cc3)C(=O)c4ccc(Cl)cc4)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N15 compound treatment 125240.0 23100.0 0.38 65560.0 -26100.0 -0.42 -0.0251 -0.0445 3085535 TimTec1_005581 OC(=O)CN1C(=O)/C(=C\c2ccsc2)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N16 compound treatment 31640.0 -70500.0 -1.16 19000.0 -72700.0 -1.16 -1.6424 -1.0 3211425 TimTec1_005582 Oc1ccccc1/C=N/c2ccc3nc(SCC(=O)NCCOc4ccccc4)sc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N17 compound treatment 119600.0 17400.0 0.29 71160.0 -20500.0 -0.33 -0.0278 -0.0639 1583377 TimTec1_005583 CC1CN(CN2C(=O)c3ccccc3C2=O)CC(C)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N18 compound treatment 114440.0 12300.0 0.2 62000.0 -29700.0 -0.47 -0.1913 -0.3718 1137144 TimTec1_005584 Nc1nnc(CCN2CCCCC2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N19 compound treatment 109720.0 7550.0 0.12 82480.0 -9200.0 -0.15 -0.0156 -0.081 3211426 TimTec1_005585 CC1=C(C(NC(=O)N1)c2ccc3OCOc3c2)C(=O)OCC(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N20 compound treatment 110960.0 8790.0 0.15 63520.0 -28200.0 -0.45 -0.2148 -0.4554 3211427 TimTec1_005586 COc1cc(/C=C\2/S/C(=N/Cc3ccccc3)/N(Cc4ccccc4)C2=O)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N21 compound treatment 41400.0 -60800.0 -1.0 27640.0 -64000.0 -1.02 -1.4311 -1.0 3085538 TimTec1_005587 Cc1ccc(/C=N/c2ccc(Nc3ccccc3)cc2)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N22 compound treatment 8360.0 -93800.0 -1.55 4840.0 -86800.0 -1.38 -2.0737 -0.9984 1176605 TimTec1_005588 Fc1ccc(cc1)c2nc3c([nH]2)c4ccccc4c5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N23 mock treatment 156000.0 53800.0 0.89 78280.0 -13400.0 -0.21 0.4773 0.5223 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 N24 mock treatment 121120.0 18900.0 0.31 90320.0 -1360.0 -0.02 0.2058 0.6565 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O01 compound treatment 4520.0 -97700.0 -1.61 2920.0 -88800.0 -1.41 -2.1402 -0.9979 1527225 TimTec1_005589 CCc1cc2c(=O)c(c3nc4ccccc4[nH]3)c(C)oc2cc1O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O02 compound treatment 4240.0 -97900.0 -1.62 2360.0 -89300.0 -1.42 -2.1498 -0.998 3085541 TimTec1_005590 NC1=C(C#N)C2=CCSC[C@H]2[C@H](c3cccc(Cl)c3)C1(C#N)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O03 compound treatment 51640.0 -50500.0 -0.83 24600.0 -67100.0 -1.07 -1.3458 -0.9925 1190084 TimTec1_005591 CCOc1ccccc1C(=O)NCCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O04 compound treatment 106160.0 3990.0 0.07 63200.0 -28500.0 -0.45 -0.2744 -0.5983 1047189 TimTec1_005592 Clc1ccc(cc1)S(=O)(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O05 compound treatment 90840.0 -11300.0 -0.19 50800.0 -40900.0 -0.65 -0.593 -0.8748 3211428 TimTec1_005593 CC(C)(C)OC(=O)C1CCC(CN1)C(=O)Oc2ccc3c4CCCCc4c(=O)oc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O06 compound treatment 87400.0 -14800.0 -0.24 51120.0 -40600.0 -0.65 -0.6296 -0.9112 1652072 TimTec1_005594 COC(=O)C1C(C(C(=O)OC)C(C)(O)CC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O07 compound treatment 156920.0 54700.0 0.9 41680.0 -50000.0 -0.8 0.0755 0.0627 3211429 TimTec1_005595 Clc1cccc(NC(=O)N=C2NCCCCCN2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O08 compound treatment 105160.0 2990.0 0.05 60080.0 -31600.0 -0.5 -0.3213 -0.6348 1649723 TimTec1_005596 CC(C)CN1C(=O)N(C(n2oc(=O)n(c3ccccc3)c2=O)C1(C)C)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O09 compound treatment 61680.0 -40500.0 -0.67 22320.0 -69400.0 -1.11 -1.2543 -0.971 1511407 TimTec1_005597 CCc1c(C)c(C#N)c2nc3ccccc3n2c1NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O10 compound treatment 14840.0 -87300.0 -1.44 10240.0 -81400.0 -1.3 -1.9372 -0.9986 3085546 TimTec1_005598 Cc1ccccc1c2ccc3cccc(C)c3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O11 compound treatment 8160.0 -94000.0 -1.55 4880.0 -86800.0 -1.38 -2.0756 -0.9984 3211430 TimTec1_005599 S(c1nnc[nH]1)c2nc3ccccc3nc2Sc4nnc[nH]4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O12 compound treatment 83480.0 -18700.0 -0.31 72440.0 -19200.0 -0.31 -0.435 -1.0 1067246 TimTec1_005600 COc1ccc(C)c2C(=O)CCCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O13 compound treatment 95560.0 -6610.0 -0.11 77560.0 -14100.0 -0.23 -0.2363 -0.9448 1520144 TimTec1_005601 CC(NC(=O)OCc1ccccc1)C(=O)Oc2ccc3c(=O)c(coc3c2)c4ccc(F)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O14 compound treatment 69360.0 -32800.0 -0.54 45240.0 -46400.0 -0.74 -0.9064 -0.9882 1641803 TimTec1_005602 Clc1cc(OC(=O)C2CCCCC2)ccc1OC(=O)C3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O15 compound treatment 11160.0 -91000.0 -1.5 4520.0 -87200.0 -1.39 -2.0446 -0.9992 3211431 TimTec1_005603 OC1=C(C#N)[C@@H]([C@H](C(=O)N1CCc2ccccc2)[n+]3ccccc3)c4ccc(Cl)cc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O16 compound treatment 124040.0 21900.0 0.36 36520.0 -55200.0 -0.88 -0.3664 -0.3855 1578376 TimTec1_005604 Cc1cc(=O)oc2cc(OC(=O)c3cc4ccccc4o3)ccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O17 compound treatment 90520.0 -11700.0 -0.19 40880.0 -50800.0 -0.81 -0.7085 -0.8514 3211432 TimTec1_005605 CCc1nc(SC/C=C/c2ccccc2)c(C#N)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O18 compound treatment 101160.0 -1010.0 -0.02 43720.0 -48000.0 -0.76 -0.5523 -0.7224 1218415 TimTec1_005606 CCOC(=O)C1=C(C)NC(=S)NC1c2ccc(OCC(=O)N3CCCCC3)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O19 compound treatment 39480.0 -62700.0 -1.03 4040.0 -87600.0 -1.4 -1.7195 -0.9891 1784221 TimTec1_005607 CCc1oc2ccccc2c1C(=O)CCN3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O20 compound treatment 102960.0 789.0 0.01 70160.0 -21500.0 -0.34 -0.2333 -0.6798 3085555 TimTec1_005608 Cc1c(Cl)cccc1NC2=NS(=O)(=O)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O21 compound treatment 113480.0 11300.0 0.19 75760.0 -15900.0 -0.25 -0.0474 -0.1506 1638741 TimTec1_005609 CC(C)NC(=O)C1CN(CCN1S(=O)(=O)c2ccccc2)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O22 compound treatment 125360.0 23200.0 0.38 70640.0 -21000.0 -0.34 0.0335 0.0659 3211433 TimTec1_005610 COc1ccc(cc1)C(=O)CSc2nsc(SCC(=O)c3ccc(OC)cc3)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O23 mock treatment 150040.0 47900.0 0.79 75840.0 -15800.0 -0.25 0.3802 0.4583 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 O24 mock treatment 135280.0 33100.0 0.55 73200.0 -18500.0 -0.29 0.1782 0.287 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P01 compound treatment 30920.0 -71300.0 -1.18 45040.0 -46600.0 -0.74 -1.3573 -0.9755 3085557 TimTec1_005611 Oc1ccc(Br)cc1/C=N/CC2CCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P02 compound treatment 51560.0 -50600.0 -0.84 48760.0 -42900.0 -0.68 -1.0745 -0.9951 1175377 TimTec1_005612 Sc1nnc2c3ccccc3n(Cc4ccccc4)c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P03 compound treatment 53600.0 -48600.0 -0.8 34480.0 -57200.0 -0.91 -1.2116 -0.9979 3211434 TimTec1_005613 Cc1ccccc1c2nnc3-c4ccccc4CC(C)(C)n23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P04 compound treatment 15640.0 -86500.0 -1.43 7280.0 -84400.0 -1.35 -1.9612 -0.9996 1673398 TimTec1_005614 CCCC1C(C2c3ccccc3C1c4ccccc24)C(=O)Nc5ccccc5OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P05 compound treatment 102280.0 109.0 0.0 57040.0 -34600.0 -0.55 -0.3891 -0.7048 1642050 TimTec1_005615 N#Cc1ccc(cc1C#N)n2nnc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P06 compound treatment 107640.0 5470.0 0.09 56280.0 -35400.0 -0.56 -0.3351 -0.5865 1492547 TimTec1_005616 CC1(C)CC(=O)c2cc(c3ccc(Br)cc3)n(CC(=O)O)c2C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P07 compound treatment 100360.0 -1810.0 -0.03 47160.0 -44500.0 -0.71 -0.5229 -0.7362 3085561 TimTec1_005617 Oc1ccc(/C=N/c2ccc3[nH]c(=O)[nH]c3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P08 compound treatment 7120.0 -95100.0 -1.57 2640.0 -89000.0 -1.42 -2.113 -0.9987 3211435 TimTec1_005618 CCOc1ccc2ccccc2c1/C=C/3\C(=O)NC(=S)N(C3=O)c4cccc(Cl)c4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P09 compound treatment 77800.0 -24400.0 -0.4 31240.0 -60400.0 -0.96 -0.9657 -0.925 3085562 TimTec1_005619 COc1cccc(c1)c2nnc(SCC(=O)NCCOc3ccccc3)n2c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P10 compound treatment 112680.0 10500.0 0.17 49680.0 -42000.0 -0.67 -0.3507 -0.5071 3211436 TimTec1_005620 Cn1cnnc1SCN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P11 compound treatment 93280.0 -8890.0 -0.15 44640.0 -47000.0 -0.75 -0.6339 -0.8298 1443624 TimTec1_005621 CCOP(=O)(C)C1(CC1)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P12 compound treatment 107080.0 4910.0 0.08 68800.0 -22900.0 -0.36 -0.2006 -0.5369 1354424 TimTec1_005622 CCN(CC)C(=O)C1(CC1)P(=O)(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P13 compound treatment 86720.0 -15500.0 -0.26 55800.0 -35900.0 -0.57 -0.5847 -0.9338 1466364 TimTec1_005623 COCc1cc(C)c2c(n1)sc3c4nc5ccccc5n4c(C)nc32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P14 compound treatment 68160.0 -34000.0 -0.56 33520.0 -58200.0 -0.93 -1.0525 -0.9711 3211437 TimTec1_005624 C=CCN/1C(=O)/C(=C\c2cccs2)/S\C1=N\c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P15 compound treatment 63800.0 -38400.0 -0.63 38080.0 -53600.0 -0.85 -1.052 -0.9892 1444037 TimTec1_005625 Nc1nc(CCc2ccccc2)c(C#N)c(N)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P16 compound treatment 54200.0 -48000.0 -0.79 27040.0 -64600.0 -1.03 -1.2885 -0.9915 3085567 TimTec1_005626 COc1ccc2NC(=O)/C(=C/3\SC(=S)NC3=O)/c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P17 compound treatment 4480.0 -97700.0 -1.61 2320.0 -89400.0 -1.42 -2.1474 -0.9981 1603829 TimTec1_005627 Nc1nc(CSc2nc3ccccc3s2)nc(Nc4ccccc4)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P18 compound treatment 53200.0 -49000.0 -0.81 18080.0 -73600.0 -1.17 -1.4011 -0.9835 1171831 TimTec1_005628 Cc1ccc(Nc2nc(C)nc3c4ccccc4oc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P19 compound treatment 93120.0 -9050.0 -0.15 49520.0 -42200.0 -0.67 -0.5808 -0.8437 1524350 TimTec1_005629 COC(=O)c1ccc(NC(=O)Cn2nc(SC)n(N)c2=S)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P20 compound treatment 38000.0 -64200.0 -1.06 12640.0 -79000.0 -1.26 -1.6398 -0.9963 3211438 TimTec1_005630 CCOC(=O)/C=C/c1ccco1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P21 compound treatment 74960.0 -27200.0 -0.45 59680.0 -32000.0 -0.51 -0.6783 -0.998 3211439 TimTec1_005631 CCOC(=O)C1C2NC(=S)N[C@]1(C)Oc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P22 compound treatment 89800.0 -12400.0 -0.2 72000.0 -19700.0 -0.31 -0.3662 -0.9784 3085589 TimTec1_005632 COc1cc(/C=C\2/C(=NN(C2=O)c3ccc(Cl)c(c3)C(=O)O)C)ccc1OCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P23 mock treatment 102800.0 629.0 0.01 68960.0 -22700.0 -0.36 -0.2487 -0.6866 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2078 P24 mock treatment 56080.0 -46100.0 -0.76 66520.0 -25200.0 -0.4 -0.8216 -0.9552 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A01 compound treatment 27720.0 -22100.0 -0.36 31560.0 -11700.0 -0.19 -0.3898 -0.9515 3211440 TimTec1_005633 CC(=O)n1cc(/C=c\2/sc3nc4c(C)c(C)ccc4n3c2=O)c(n1)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A02 compound treatment 2920.0 -46900.0 -0.77 4120.0 -39100.0 -0.62 -0.9886 -0.9943 3085592 TimTec1_005634 Cc1nc(N)sc1c2csc(Nc3cccc(Cl)c3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A03 compound treatment 59160.0 9340.0 0.15 69760.0 26500.0 0.42 0.4077 0.9068 3211529 TimTec1_005635 CCC(=O)N1N=C(CC1(O)c2ccc(F)cc2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A04 compound treatment 124800.0 75000.0 1.24 119360.0 76100.0 1.21 1.7328 0.9999 1419705 TimTec1_005636 CC1CCC(=C(C#N)C(=O)NCc2ccccc2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A05 compound treatment 49040.0 -778.0 -0.01 22680.0 -20600.0 -0.33 -0.2411 -0.7342 1732858 TimTec1_005637 Fc1ccc2C(=O)N(C3CCCCCCC3)C(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A06 compound treatment 30680.0 -19100.0 -0.32 21440.0 -21800.0 -0.35 -0.4693 -0.9988 3211530 TimTec1_005638 Fc1ccc(cc1)C2Nc3ccc(OC(F)(F)F)cc3C4C=CCC42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A07 compound treatment 157000.0 107000.0 1.77 177760.0 134000.0 2.14 2.7669 0.9955 1737054 TimTec1_005639 Nn1c(CO)nc2ccccc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A08 compound treatment 114280.0 64500.0 1.06 124840.0 81600.0 1.3 1.6718 0.9951 1175030 TimTec1_005640 CC(C)(O)c1cn2ccccc2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A09 compound treatment 122040.0 72200.0 1.19 121320.0 78100.0 1.24 1.7227 0.9998 1364286 TimTec1_005641 COc1ccc(cc1)C(CC#N)C2CCOC(C)(C)C2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A10 compound treatment 150520.0 101000.0 1.66 130880.0 87600.0 1.4 2.1629 0.9962 1357576 TimTec1_005642 O=C(NCCc1ccc(cc1)S(=O)(=O)N2CCCC2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A11 compound treatment 36400.0 -13400.0 -0.22 21640.0 -21600.0 -0.34 -0.4003 -0.9771 3211531 TimTec1_005643 CNC(=S)N(C)/N=C\1/C(=O)N(Cc2c(Cl)cccc2Cl)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A12 compound treatment 175400.0 126000.0 2.07 155680.0 112000.0 1.79 2.7328 0.9974 3085598 TimTec1_005644 CCc1nn2c(C)cc(O)nc2c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A13 compound treatment 152120.0 102000.0 1.69 114240.0 71000.0 1.13 1.994 0.981 1530862 TimTec1_005645 C1Cc2c(C1)c3c(ccc4ccccc43)nc2c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A14 compound treatment 175760.0 126000.0 2.08 171680.0 128000.0 2.05 2.9173 1.0 1575017 TimTec1_005646 CC1CN(OC(O1)c2ccc3OCOc3c2)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A15 compound treatment 154240.0 104000.0 1.72 161960.0 119000.0 1.89 2.5566 0.9989 3085600 TimTec1_005647 OC(=O)C1CC(=O)N(Cc2ccccc2)/C(=N/c3ccc(F)cc3)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A16 compound treatment 75880.0 26100.0 0.43 100480.0 57200.0 0.91 0.9491 0.9412 1628881 TimTec1_005648 CCC(N)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A17 compound treatment 134160.0 84300.0 1.39 123800.0 80500.0 1.28 1.8921 0.9992 3085602 TimTec1_005649 FC(F)(F)c1cccc(NCn2c(=S)oc3ccc(Cl)cc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A18 compound treatment 121040.0 71200.0 1.18 106480.0 63200.0 1.01 1.5438 0.997 1127153 TimTec1_005650 CC(C)c1ccccc1NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A19 compound treatment 129760.0 79900.0 1.32 141960.0 98700.0 1.57 2.0454 0.9962 1348096 TimTec1_005651 CN(C)c1nc2n(C)c(=O)n(C)c(=O)c2n1CC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A20 compound treatment 106480.0 56700.0 0.94 91280.0 48000.0 0.77 1.2025 0.995 1611764 TimTec1_005652 COC(=O)CCn1cc(F)c(N)nc1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A21 compound treatment 80000.0 30200.0 0.5 74160.0 30900.0 0.49 0.7005 1.0 1564099 TimTec1_005653 CN(C)N=Nc1ccc(cc1)S(=O)(=O)NC(=O)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A22 compound treatment 71120.0 21300.0 0.35 58720.0 15500.0 0.25 0.4228 0.9848 1394944 TimTec1_005654 C=CCn1c(SCc2nc3ccccc3[nH]2)nnc1c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A23 mock treatment 60600.0 10800.0 0.18 62960.0 19700.0 0.31 0.3478 0.9639 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 A24 mock treatment 39800.0 -10000.0 -0.17 30960.0 -12300.0 -0.2 -0.2556 -0.9964 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B01 compound treatment 69120.0 19300.0 0.32 115760.0 72500.0 1.16 1.0424 0.8696 3211532 TimTec1_005655 SC1=NC(=O)/C(=C\c2cccnc2)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B02 compound treatment 3840.0 -46000.0 -0.76 4400.0 -38900.0 -0.62 -0.9747 -0.9949 1491875 TimTec1_005656 COc1ccc(cc1)S(=O)(=O)NCCC2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B03 compound treatment 123360.0 73500.0 1.21 149880.0 107000.0 1.7 2.06 0.9864 3085609 TimTec1_005657 Cc1nn(c(O)c1CCC#N)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B04 compound treatment 35240.0 -14600.0 -0.24 25760.0 -17500.0 -0.28 -0.3674 -0.9973 3211533 TimTec1_005658 FC(F)(F)C(NCC1(CC2CC3CC(C2)C1)C3)(NC(=O)c4ccccc4)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B05 compound treatment 178080.0 128000.0 2.12 168160.0 125000.0 1.99 2.9047 0.9995 3085612 TimTec1_005659 COc1cc(NC=C2C(=O)NC(=O)NC2=O)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B06 compound treatment 182720.0 133000.0 2.19 159080.0 116000.0 1.85 2.8566 0.9963 3085613 TimTec1_005660 Cc1cc(cc(C)c1O)C(O)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B07 compound treatment 32280.0 -17500.0 -0.29 35680.0 -7580.0 -0.12 -0.2902 -0.925 3211534 TimTec1_005661 FC(F)(F)c1ccccc1C2C3=C(CCCC3=O)Nc4ccc5ncccc5c24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B08 compound treatment 158400.0 109000.0 1.79 164520.0 121000.0 1.93 2.634 0.9993 1339353 TimTec1_005662 CCc1ccc(cc1)C(=O)c2c(c(c3cc(ccn23)C(C)(C)C)S(=O)(=O)CC)S(=O)(=O)CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B09 compound treatment 195960.0 146000.0 2.41 141640.0 98400.0 1.57 2.8146 0.9782 1735427 TimTec1_005663 CC1(C)CC(=O)CC(C)(C)N1OC(=O)c2ccccn2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B10 compound treatment 115120.0 65300.0 1.08 79840.0 36600.0 0.58 1.1745 0.9583 1503527 TimTec1_005664 CCC(NC(=O)c1ccc(cc1)S(=O)(=O)N2CCOCC2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B11 compound treatment 98880.0 49100.0 0.81 64000.0 20700.0 0.33 0.8064 0.9219 1555325 TimTec1_005665 CCOc1ccccc1NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B12 compound treatment 170920.0 121000.0 2.0 151720.0 108000.0 1.73 2.6359 0.9974 3085617 TimTec1_005666 COc1ccc(/C=N/n2c(=O)c(nn3cnnc23)C(C)(C)C)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B13 compound treatment 146480.0 96700.0 1.6 89360.0 46100.0 0.73 1.6478 0.938 1402991 TimTec1_005667 Cc1ccc(Oc2cc(C#N)c(C#N)cc2n3nnc4ccccc34)cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B14 compound treatment 84240.0 34400.0 0.57 79240.0 36000.0 0.57 0.8073 1.0 3085619 TimTec1_005668 CC/N=C\1/S/C(=C/c2sccc2C)/C(=O)N1CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B15 compound treatment 17200.0 -32600.0 -0.54 9640.0 -33600.0 -0.54 -0.7597 -1.0 1257857 TimTec1_005669 OC1=C(C(C#Cc2ccccc2)C3=C(O)CCCC3=O)C(=O)CCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B16 compound treatment 150360.0 101000.0 1.66 103120.0 59900.0 0.95 1.8482 0.9654 1631021 TimTec1_005670 COc1ccccc1N2CCN(CC2)S(=O)(=O)c3c(C)ccc4nsnc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B17 compound treatment 206440.0 157000.0 2.59 160000.0 117000.0 1.86 3.1438 0.987 1219783 TimTec1_005671 COc1ccc(cc1)N2C(=O)NC(=O)C(Cc3ccc(O)c(OC)c3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B18 compound treatment 170520.0 121000.0 1.99 152000.0 109000.0 1.73 2.6344 0.9976 3211535 TimTec1_005672 Cc1cc(NC(=O)NC(=O)c2ccc(F)cc2)n[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B19 compound treatment 192680.0 143000.0 2.36 138920.0 95700.0 1.52 2.7456 0.9777 1033315 TimTec1_005673 Cc1cc(C)n(n1)C(=S)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B20 compound treatment 126440.0 76600.0 1.26 127160.0 83900.0 1.34 1.8399 0.9996 3085624 TimTec1_005674 CSc1snc(O)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B21 compound treatment 107560.0 57700.0 0.95 75400.0 32100.0 0.51 1.0362 0.9576 3211536 TimTec1_005675 CCc1ccc(cc1)C2=Nn3c(C)nnc3SC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B22 compound treatment 67520.0 17700.0 0.29 54320.0 11100.0 0.18 0.3312 0.9707 3085626 TimTec1_005676 O=C(Nc1cccc(c1)c2nnc(o2)c3ccco3)C(c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B23 mock treatment 115200.0 65400.0 1.08 71800.0 28500.0 0.45 1.0848 0.9262 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 B24 mock treatment 60400.0 10600.0 0.17 49240.0 5980.0 0.1 0.1909 0.9593 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C01 compound treatment 30200.0 -19600.0 -0.32 17440.0 -25800.0 -0.41 -0.52 -0.993 1675170 TimTec1_005677 C(Oc1cccc(c1)c2nnc3ccc4ccccc4n23)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C02 compound treatment 8560.0 -41300.0 -0.68 6920.0 -36300.0 -0.58 -0.8912 -0.9968 1346658 TimTec1_005678 Fc1ccccc1C2Nc3ccc4ccccc4c3C5C=CCC52 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C03 compound treatment 128160.0 78300.0 1.29 82280.0 39000.0 0.62 1.3542 0.9437 3085628 TimTec1_005679 COC(C)n1cc(Br)c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C04 compound treatment 113440.0 63600.0 1.05 105560.0 62300.0 0.99 1.4447 0.9996 1681244 TimTec1_005680 Cc1cc(Oc2cc(C#N)c3ccccc3n2)ccc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C05 compound treatment 124640.0 74800.0 1.24 128680.0 85400.0 1.36 1.836 0.9988 3085667 TimTec1_005681 Fc1ccc2C(=O)N(N3CCOCC3)C(=O)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C06 compound treatment 6520.0 -43300.0 -0.71 6360.0 -36900.0 -0.59 -0.9213 -0.9953 1270347 TimTec1_005682 Cn1c(=N)n(CC(=O)C2(CC3CC4CC(C3)C2)C4)c5ccccc15 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C07 compound treatment 57280.0 7460.0 0.12 50920.0 7660.0 0.12 0.1734 1.0 1454435 TimTec1_005683 CSc1nc2-c3ccccc3CC(C)(C)c2c(=O)n1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C08 compound treatment 75120.0 25300.0 0.42 62240.0 19000.0 0.3 0.5092 0.9874 1371600 TimTec1_005684 Cc1ccc(cc1)C(=O)Cn2c(=N)n(C)c3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C09 compound treatment 11480.0 -38300.0 -0.63 23080.0 -20200.0 -0.32 -0.675 -0.9508 1605543 TimTec1_005685 CSC1=NC2(Cc3ccccc13)CCCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C10 compound treatment 168080.0 118000.0 1.95 114640.0 71400.0 1.14 2.1848 0.967 1564745 TimTec1_005686 CC(C)(O)C#Cc1ccc(cc1)C(=O)NCC(c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C11 compound treatment 176520.0 127000.0 2.09 126000.0 82700.0 1.32 2.4114 0.9753 3085653 TimTec1_005687 O=C(Nc1ccccc1)OCC23COC(N3C(OC2)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C12 compound treatment 41320.0 -8500.0 -0.14 40360.0 -2900.0 -0.05 -0.1319 -0.8931 1696532 TimTec1_005688 O=C1N(C(Nc2ccccc12)c3cccs3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C13 compound treatment 62720.0 12900.0 0.21 35200.0 -8060.0 -0.13 0.0597 0.2401 3211537 TimTec1_005689 Cc1ccc(/N=C/2\NC(=O)C(Cc3cccc(c3)C(F)(F)F)S2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C14 compound treatment 93760.0 43900.0 0.73 89600.0 46300.0 0.74 1.0351 1.0 1190215 TimTec1_005690 CC(C1Nc2ccccc2C(=O)N1c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C15 compound treatment 96040.0 46200.0 0.76 73920.0 30700.0 0.49 0.885 0.9768 1378935 TimTec1_005691 CCOC(=O)c1c(NC(=O)CSc2ncccn2)sc3CCCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C16 compound treatment 187200.0 137000.0 2.27 122160.0 78900.0 1.26 2.4928 0.9613 1327450 TimTec1_005692 CCC(=O)Nc1nonc1c2nc3ccccc3n2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C17 compound treatment 196440.0 147000.0 2.42 127880.0 84600.0 1.35 2.6651 0.9619 3211622 TimTec1_005693 CCC(=O)NC(Nc1sc2CCCCc2c1C#N)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C18 compound treatment 203680.0 154000.0 2.54 123680.0 80400.0 1.28 2.7023 0.9498 1168333 TimTec1_005694 CC(C)CCN1NC2(CCCCC2)NC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C19 compound treatment 169480.0 120000.0 1.98 108840.0 65600.0 1.05 2.1358 0.9557 3211623 TimTec1_005695 CN1C2=C(C(NC1=O)c3ccccc3)C(=O)N(C2)c4ccc(C)c(C)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C20 compound treatment 158200.0 108000.0 1.79 108600.0 65300.0 1.04 2.0014 0.9668 1532646 TimTec1_005696 Cn1nccc1C(=O)NCCN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C21 compound treatment 115040.0 65200.0 1.08 80120.0 36900.0 0.59 1.1767 0.9594 1534811 TimTec1_005697 COc1c(O)ccc2c(OC)c3ccoc3nc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C22 compound treatment 77840.0 28000.0 0.46 44520.0 1260.0 0.02 0.3412 0.737 3085660 TimTec1_005698 Cn1c2ccccc2c3nnc(SCc4ccc(F)cc4Cl)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C23 mock treatment 83320.0 33500.0 0.55 65600.0 22300.0 0.36 0.6428 0.9773 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 C24 mock treatment 69440.0 19600.0 0.32 46320.0 3060.0 0.05 0.2635 0.8044 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D01 compound treatment 14720.0 -35100.0 -0.58 7960.0 -35300.0 -0.56 -0.8076 -0.9999 3211624 TimTec1_005699 CC1CN=C(S1)N(C(=O)Nc2ccccc2)c3ccc(OC(F)(F)F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D02 compound treatment 78880.0 29100.0 0.48 58560.0 15300.0 0.24 0.5116 0.9507 3085662 TimTec1_005700 C(Sc1ncn[nH]1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D03 compound treatment 24840.0 -25000.0 -0.41 17080.0 -26200.0 -0.42 -0.5866 -1.0 3211625 TimTec1_005701 Cc1ccc(NC(=O)C2CC(=O)N(Cc3ccccc3)/C(=N/c4ccccc4)/S2)c(C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D04 compound treatment 19760.0 -30100.0 -0.5 15360.0 -27900.0 -0.44 -0.6653 -0.9985 3085663 TimTec1_005702 FC(F)(F)C(NCCc1c[nH]c2ccccc12)(NC(=O)c3ccccc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D05 compound treatment 8960.0 -40900.0 -0.67 5360.0 -37900.0 -0.6 -0.9041 -0.9985 3211626 TimTec1_005703 CCC1(C)OC(=Nc2ccccc21)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D06 compound treatment 3960.0 -45900.0 -0.76 4520.0 -38700.0 -0.62 -0.9719 -0.9949 1384761 TimTec1_005704 Oc1ccc(NC2=C(C(=O)c3ccccc3C2=O)n4nnc5ccccc45)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D07 compound treatment 35280.0 -14500.0 -0.24 35720.0 -7540.0 -0.12 -0.2547 -0.9489 1725838 TimTec1_005705 CSc1ccc(cc1)C2C3=C(CCCC3=O)Nc4ccc5ccccc5c24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D08 compound treatment 63920.0 14100.0 0.23 57080.0 13800.0 0.22 0.3203 0.9996 1630880 TimTec1_005706 Cn1c(nn(C2CC(=O)C3OCC2O3)c1=S)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D09 compound treatment 9160.0 -40700.0 -0.67 8880.0 -34400.0 -0.55 -0.8621 -0.9949 1339859 TimTec1_005707 COc1cc2ccccc2cc1C(=O)NCCC3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D10 compound treatment 127880.0 78100.0 1.29 116000.0 72700.0 1.16 1.7309 0.9986 1488964 TimTec1_005708 CC(C)(C)c1ccc(cc1)C23OC(=O)C(C)(C)C3OC(=O)C2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D11 compound treatment 60720.0 10900.0 0.18 52640.0 9380.0 0.15 0.2329 0.9957 1458934 TimTec1_005709 C1CN(CCN1)C2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D12 compound treatment 10280.0 -39500.0 -0.65 11200.0 -32100.0 -0.51 -0.8229 -0.9927 3211627 TimTec1_005710 O=C/1NC(=S)N\C1=C\c2cc3ccccc3nc2N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D13 compound treatment 101880.0 52100.0 0.86 86680.0 43400.0 0.69 1.097 0.9942 1617853 TimTec1_005711 Cc1cccc(C)c1NC(=O)C2(CCCC2)N(Cc3ccccc3)C(=O)c4ccc(cc4)n5cnnn5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D14 compound treatment 111160.0 61300.0 1.01 107120.0 63900.0 1.02 1.4357 1.0 1422235 TimTec1_005712 Brc1ccc(CC2(CCc3ccncc3)C(=O)NC(=O)NC2=O)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D15 compound treatment 9360.0 -40500.0 -0.67 7920.0 -35300.0 -0.56 -0.8706 -0.9964 3211628 TimTec1_005713 CCN(CC)c1ccc(cc1)C2(NN(C(=C2C#N)N)c3ccccc3)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D16 compound treatment 52800.0 2980.0 0.05 44280.0 1020.0 0.02 0.0463 0.8927 3085673 TimTec1_005714 C/C(=N\c1ccccc1)/C2=C(O)C=C(CC2c3ccco3)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D17 compound treatment 78880.0 29100.0 0.48 59440.0 16200.0 0.26 0.5215 0.9576 3211629 TimTec1_005715 Fc1ccc(CCN2C(=O)NC(=O)/C(=C\c3cccc4ccccc34)/C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D18 compound treatment 52640.0 2820.0 0.05 62360.0 19100.0 0.3 0.2482 0.806 1524909 TimTec1_005716 COc1ccccc1c2nnc(o2)c3ccccc3O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D19 compound treatment 34320.0 -15500.0 -0.26 25680.0 -17600.0 -0.28 -0.3791 -0.999 3211630 TimTec1_005717 COc1cccc(c1)c2cc(nc(SC3CC(=O)C4OCC3O4)n2)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D20 compound treatment 169640.0 120000.0 1.98 109680.0 66400.0 1.06 2.1471 0.9571 3085676 TimTec1_005718 FC(F)(F)c1cccc(c1)N2C(=O)CC(Cc3ccccc3)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D21 compound treatment 91680.0 41900.0 0.69 77280.0 34000.0 0.54 0.872 0.9928 3211631 TimTec1_005719 CC1(C)OC(=O)C(=Cc2cccn2c3ccc(cc3)S(=O)(=O)N)C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D22 compound treatment 74920.0 25100.0 0.41 56840.0 13600.0 0.22 0.446 0.9541 3085679 TimTec1_005720 Cc1cccc2nc(=S)n(C(=O)c3ccc(F)cc3)n12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D23 mock treatment 70000.0 20200.0 0.33 82560.0 39300.0 0.63 0.6785 0.9564 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 D24 mock treatment 76200.0 26400.0 0.44 41240.0 -2020.0 -0.03 0.2851 0.6529 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E01 compound treatment 75240.0 25400.0 0.42 74280.0 31000.0 0.49 0.6463 0.9967 3211632 TimTec1_005721 Cc1cc(F)c(F)c(C(=O)n2ccnc2)c1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E02 compound treatment 46600.0 -3220.0 -0.05 44960.0 1700.0 0.03 -0.0184 -0.3094 1584802 TimTec1_005722 O=C(CSc1ccccc1)Nc2c(oc3ccccc23)C(=O)C4CC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E03 compound treatment 75240.0 25400.0 0.42 73800.0 30500.0 0.49 0.6409 0.9973 3211633 TimTec1_005723 COCc1cc(C)nc2sc(C(=O)OC)c(N)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E04 compound treatment 7360.0 -42500.0 -0.7 7760.0 -35500.0 -0.57 -0.8957 -0.9944 3211634 TimTec1_005724 CC(C)COC(=O)C1=C(C)Nc2cc(ccc2S1)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E05 compound treatment 16480.0 -33300.0 -0.55 10680.0 -32600.0 -0.52 -0.7564 -0.9996 3085682 TimTec1_005725 Fc1ccc(COc2ccccc2/C=C\3/C(=O)NC(=O)N(CC=C)C3=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E06 compound treatment 8920.0 -40900.0 -0.68 9200.0 -34100.0 -0.54 -0.8613 -0.9942 3211635 TimTec1_005726 CN(C)c1ccc(/C=C\2/Oc3c(ccc(O)c3O)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E07 compound treatment 56560.0 6740.0 0.11 64400.0 21100.0 0.34 0.3169 0.8932 3211636 TimTec1_005727 CCn/1c(cs\c1=N\c2cc(OC)c(Cl)cc2OC)c3ccc(F)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E08 compound treatment 32760.0 -17100.0 -0.28 56960.0 13700.0 0.22 -0.0447 -0.1256 1668810 TimTec1_005728 N=C1OC23CCCCC3C(C#N)(C#N)C1(C#N)C(Cc4ccccc4)O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E09 compound treatment 122000.0 72200.0 1.19 118000.0 74700.0 1.19 1.6848 1.0 1468867 TimTec1_005729 NS(=O)(=O)c1ccc(N=NN2CCCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E10 compound treatment 35240.0 -14600.0 -0.24 38360.0 -4900.0 -0.08 -0.2254 -0.891 1221615 TimTec1_005730 CCc1ccc2cc(cn2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E11 compound treatment 105160.0 55300.0 0.91 108720.0 65500.0 1.04 1.3837 0.9978 3211637 TimTec1_005731 CC1SC(N(C1=O)c2ccccc2)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E12 compound treatment 124320.0 74500.0 1.23 121840.0 78600.0 1.25 1.7552 1.0 1203111 TimTec1_005732 Cc1cc(C(=O)O)c(C#N)c(N)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E13 compound treatment 102600.0 52800.0 0.87 105040.0 61800.0 0.98 1.3123 0.9981 3211638 TimTec1_005733 NC(=NS(=O)(=O)c1ccc(NC(=O)c2ccc(Cl)cc2)cc1)N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E14 compound treatment 99120.0 49300.0 0.81 108080.0 64800.0 1.03 1.306 0.993 3085709 TimTec1_005734 Cc1nc2ccccc2c(=O)n1c3ccc4OC(F)(F)Oc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E15 compound treatment 111520.0 61700.0 1.02 136360.0 93100.0 1.48 1.7694 0.9831 3085711 TimTec1_005735 C/C(=C/C(=O)C1CC1)/C2CC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E16 compound treatment 22880.0 -26900.0 -0.44 32640.0 -10600.0 -0.17 -0.4342 -0.9125 1198283 TimTec1_005736 CC(C(=O)Nc1ccc2OCCOc2c1)n3nnc(n3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E17 compound treatment 105000.0 55200.0 0.91 105080.0 61800.0 0.99 1.3408 0.9992 1200453 TimTec1_005737 CC1=C(C(C2=C(CC(C)(C)CC2=O)N1)c3ccc4OCOc4c3)C(=O)Nc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E18 compound treatment 81200.0 31400.0 0.52 83360.0 40100.0 0.64 0.8182 0.9946 1488913 TimTec1_005738 CCCc1cc(O)nc(SCC(=O)N2c3ccccc3Sc4ccccc24)n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E19 compound treatment 98560.0 48700.0 0.8 103920.0 60700.0 0.97 1.2526 0.9958 1378082 TimTec1_005739 CCOC(=O)C1(CCN(CC1)C(=O)c2ccccc2O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E20 compound treatment 99400.0 49600.0 0.82 99120.0 55900.0 0.89 1.2083 0.9991 1283200 TimTec1_005740 CC(C)N1C2OC(OC2N(C(C)C)S1(=O)=O)C3OC4C(O3)N(C(C)C)S(=O)(=O)N4C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E21 compound treatment 108800.0 59000.0 0.97 102840.0 59600.0 0.95 1.3599 0.9999 1315806 TimTec1_005741 CC(=O)Oc1ccc(C)cc1n2nc3ccccc3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E22 compound treatment 82440.0 32600.0 0.54 87600.0 44300.0 0.71 0.8805 0.991 3085715 TimTec1_005742 COc1ccccc1N/C=C/2\C(=O)NC(=O)N(C2=O)c3ccccc3OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E23 mock treatment 63960.0 14100.0 0.23 62000.0 18700.0 0.3 0.3762 0.9926 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 E24 mock treatment 50120.0 303.0 0.0 48720.0 5460.0 0.09 0.065 0.7465 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F01 compound treatment 79880.0 30100.0 0.5 70560.0 27300.0 0.44 0.6585 0.9978 1415787 TimTec1_005743 O=C(Cn1nnc(n1)c2ccc3OCOc3c2)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F02 compound treatment 56800.0 6980.0 0.12 57080.0 13800.0 0.22 0.2372 0.9544 1291024 TimTec1_005744 Cc1[nH]c2ccccc2c1CCNC(=O)c3cc4cc(Br)ccc4oc3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F03 compound treatment 36600.0 -13200.0 -0.22 33840.0 -9420.0 -0.15 -0.2605 -0.9834 3085718 TimTec1_005745 FC(F)(F)c1nnc(S)n1/N=C/c2ccc(Cl)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F04 compound treatment 65760.0 15900.0 0.26 50680.0 7420.0 0.12 0.2697 0.9347 1647381 TimTec1_005746 CC1CCN(CC1)S(=O)(=O)c2ccc(cc2)C(=O)NCc3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F05 compound treatment 100000.0 50200.0 0.83 125200.0 81900.0 1.31 1.5092 0.9759 1416263 TimTec1_005747 Cc1c(NC(=O)C2CCCC2)c(=O)n(c3ccccc3)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F06 compound treatment 88880.0 39100.0 0.64 104800.0 61500.0 0.98 1.1495 0.9793 3211747 TimTec1_005748 Cc1cc(S)c2n(Cc3ccc(Cl)cc3Cl)nc[n+]2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F07 compound treatment 115200.0 65400.0 1.08 111640.0 68400.0 1.09 1.5338 1.0 1581088 TimTec1_005749 Fc1cccc(Cl)c1C2N3CCCCN23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F08 compound treatment 48720.0 -1100.0 -0.02 43880.0 616.0 0.01 -0.0059 -0.2846 1406168 TimTec1_005750 COC(=O)c1ccc(CSc2nnc3c4ccccc4n(C)c3n2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F09 compound treatment 49520.0 -298.0 0.0 51280.0 8020.0 0.13 0.0869 0.6794 3211748 TimTec1_005751 Cc1cc(C)c(c(C)c1)n2nnnc2SCC(=O)Nc3nn(nc3C(=O)N)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F10 compound treatment 108200.0 58400.0 0.96 107120.0 63900.0 1.02 1.4011 0.9996 3087784 TimTec1_005752 CC1(NC(C2C1C(=O)N(C2=O)c3ccccc3)c4cc(Br)ccc4O)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F11 compound treatment 106680.0 56900.0 0.94 103120.0 59900.0 0.95 1.3383 1.0 3211749 TimTec1_005753 N#CCC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F12 compound treatment 93360.0 43500.0 0.72 100560.0 57300.0 0.91 1.154 0.993 1605647 TimTec1_005754 COc1ccc(cc1OC)C2C(Oc3ccc(Cl)cc3C)C(=O)N2c4ccc(C)c(C)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F13 compound treatment 130560.0 80700.0 1.33 129840.0 86600.0 1.38 1.9182 0.9998 3087785 TimTec1_005755 C[S+](C)c1c(O)n(c2ccccc2F)c(=O)[nH]c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F14 compound treatment 84880.0 35100.0 0.58 94000.0 50700.0 0.81 0.9811 0.9866 1201797 TimTec1_005756 Fc1cc(Cl)c(cc1F)C(=O)NC2C3CC4CC(C3)CC2C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F15 compound treatment 108320.0 58500.0 0.97 113680.0 70400.0 1.12 1.4765 0.9972 1326307 TimTec1_005757 CC(Sc1nc(N)cc(N)n1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F16 compound treatment 55280.0 5460.0 0.09 65400.0 22100.0 0.35 0.3132 0.8602 1664927 TimTec1_005758 C=CCn1c2ccccc2c3nnc(SCc4ccc5nonc5c4)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F17 compound treatment 107880.0 58100.0 0.96 106480.0 63200.0 1.01 1.3902 0.9997 3087786 TimTec1_005759 CC(Nc1nc(F)cc(=O)[nH]1)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F18 compound treatment 48880.0 -938.0 -0.02 56520.0 13300.0 0.21 0.1385 0.6536 3211750 TimTec1_005760 CCOC(=O)/C=C/1\NC(C)(C)Cc2cc(OC)c(O)cc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F19 compound treatment 9080.0 -40700.0 -0.67 10360.0 -32900.0 -0.52 -0.8463 -0.9924 3211751 TimTec1_005761 O=C(CSc1nnnn1c2ccccc2)NCCC3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F20 compound treatment 54320.0 4500.0 0.07 76720.0 33500.0 0.53 0.4296 0.798 3087787 TimTec1_005762 CC1SC2(CCCCC2)N(C1=O)c3cc(C)cc(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F21 compound treatment 39880.0 -9940.0 -0.16 49040.0 5780.0 0.09 -0.0509 -0.2706 3211752 TimTec1_005763 CC(=O)NC(NCCC1(CC2CC3CC(C2)C1)C3)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F22 compound treatment 61920.0 12100.0 0.2 49200.0 5940.0 0.09 0.2082 0.9417 1523330 TimTec1_005764 O=C(Oc1ccc(cc1)N(C(=O)c2ccccc2)S(=O)(=O)c3cccs3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F23 mock treatment 53480.0 3660.0 0.06 57400.0 14100.0 0.23 0.2021 0.8662 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 F24 mock treatment 53360.0 3540.0 0.06 59560.0 16300.0 0.26 0.225 0.8451 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G01 compound treatment 60160.0 10300.0 0.17 41640.0 -1620.0 -0.03 0.1024 0.5931 3087788 TimTec1_005765 Fc1ccccc1c2nnc3ccc(cn23)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G02 compound treatment 47920.0 -1900.0 -0.03 64960.0 21700.0 0.35 0.2224 0.6404 3211753 TimTec1_005766 CN1C(=O)N(C)C2(N=C3SCC(=O)N3NC12c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G03 compound treatment 73200.0 23400.0 0.39 82040.0 38800.0 0.62 0.7099 0.9743 1444799 TimTec1_005767 OC1=C(C(N(C1=O)c2cccnc2)c3ccccc3)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G04 compound treatment 51440.0 1620.0 0.03 47520.0 4260.0 0.07 0.0669 0.9174 1457617 TimTec1_005768 O=C(N1N=CCC1c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G05 compound treatment 76080.0 26300.0 0.43 78600.0 35300.0 0.56 0.7048 0.9916 1406350 TimTec1_005769 Clc1ccccc1C(=O)Nc2ccc3nc(SCC(=O)N4CCc5ccccc45)sc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G06 compound treatment 106480.0 56700.0 0.94 133760.0 90500.0 1.44 1.6813 0.978 1302719 TimTec1_005770 COC(=O)c1ccccc1NCNc2ccccc2C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G07 compound treatment 100520.0 50700.0 0.84 101400.0 58100.0 0.93 1.247 0.9987 1261268 TimTec1_005771 CCCC(=C1C(=O)NC(=O)NC1=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G08 compound treatment 93520.0 43700.0 0.72 86720.0 43500.0 0.69 0.9999 0.9998 1028239 TimTec1_005772 S=c1sscc1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G09 compound treatment 112440.0 62600.0 1.03 108280.0 65000.0 1.04 1.4637 1.0 3211754 TimTec1_005773 CCOC(=O)Cc1nc(C)cs1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G10 compound treatment 126280.0 76500.0 1.26 128040.0 84800.0 1.35 1.8479 0.9994 1366551 TimTec1_005774 CCC1C(OC(=O)C(C)(C)C1=O)c2cccc(Br)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G11 compound treatment 95760.0 45900.0 0.76 102240.0 59000.0 0.94 1.2009 0.9943 3087789 TimTec1_005775 CC(=O)OC(C)(C)C#CCN1CCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G12 compound treatment 107240.0 57400.0 0.95 110920.0 67700.0 1.08 1.4328 0.9979 3211755 TimTec1_005776 O=C/1Nc2ccccc2\C1=C/3\NC(=S)N(C3=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G13 compound treatment 119960.0 70100.0 1.16 118880.0 75600.0 1.21 1.6709 0.9998 3087790 TimTec1_005777 CCOC1=NOC2C3CCC(C3)C21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G14 compound treatment 103720.0 53900.0 0.89 115800.0 72500.0 1.16 1.4467 0.9916 3211756 TimTec1_005778 COc1ccc(cc1)C2OCC(C)(CO2)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G15 compound treatment 95320.0 45500.0 0.75 116040.0 72800.0 1.16 1.3513 0.9779 3087791 TimTec1_005779 Nc1ccc(OC(F)(F)F)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G16 compound treatment 65360.0 15500.0 0.26 82840.0 39600.0 0.63 0.6275 0.9214 1233416 TimTec1_005780 C(Sc1nnnn1c2ccc3OCOc3c2)C4CC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G17 compound treatment 103720.0 53900.0 0.89 125600.0 82300.0 1.31 1.5571 0.9821 1922264 TimTec1_005781 CC1(C)COC(O)(CC1=O)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G18 compound treatment 68480.0 18700.0 0.31 84160.0 40900.0 0.65 0.6787 0.9414 1589793 TimTec1_005782 CCc1ccc(cc1)C2Nc3ccccc3C(=O)N2c4ccc(cc4)N(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G19 compound treatment 98800.0 49000.0 0.81 102920.0 59700.0 0.95 1.2441 0.9967 3087792 TimTec1_005783 CSC1=NC2C(N1)N(C)C(=O)N2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G20 compound treatment 22560.0 -27300.0 -0.45 32640.0 -10600.0 -0.17 -0.4379 -0.9108 1362774 TimTec1_005784 N=C1OC23CCCCC3C(C#N)(C#N)C1(C#N)C(O2)c4cccnc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G21 compound treatment 102080.0 52300.0 0.86 88640.0 45400.0 0.72 1.1214 0.9962 3087793 TimTec1_005785 O=C(Oc1ccc(cc1)c2cnc3ccccc3n2)/C=C/c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G22 compound treatment 54040.0 4220.0 0.07 44960.0 1700.0 0.03 0.0684 0.915 1511555 TimTec1_005786 Clc1ccc2oc(=O)n(C(=O)NC3CCCCC3)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G23 mock treatment 66680.0 16900.0 0.28 45920.0 2660.0 0.04 0.2268 0.8054 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 G24 mock treatment 53800.0 3980.0 0.07 36720.0 -6540.0 -0.1 -0.0273 -0.2211 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H01 compound treatment 33200.0 -16600.0 -0.27 32800.0 -10500.0 -0.17 -0.3119 -0.9715 1788039 TimTec1_005787 Fc1ccccc1c2nnn(CC(=O)N3CCCCC3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H02 compound treatment 34680.0 -15100.0 -0.25 28240.0 -15000.0 -0.24 -0.346 -0.9998 1578958 TimTec1_005788 COc1ccc(Cl)cc1S(=O)(=O)N2CCN(CC2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H03 compound treatment 72720.0 22900.0 0.38 65720.0 22500.0 0.36 0.5204 0.9996 3087794 TimTec1_005789 COc1cc2CC(C)(C)N=C(NC(C)C(=O)O)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H04 compound treatment 81280.0 31500.0 0.52 79560.0 36300.0 0.58 0.7763 0.9986 3087795 TimTec1_005790 NCCN1C(=O)S/C(=C/c2cccs2)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H05 compound treatment 83840.0 34000.0 0.56 91960.0 48700.0 0.78 0.9459 0.9874 1701075 TimTec1_005791 CCn1c(=N)n(CC(=O)c2cccs2)c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H06 compound treatment 118400.0 68600.0 1.13 123320.0 80100.0 1.28 1.7028 0.9982 1332043 TimTec1_005792 COC(=O)NC1CSCC1OC(=O)CCCN2C(=O)c3ccccc3C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H07 compound treatment 96360.0 46500.0 0.77 96560.0 53300.0 0.85 1.1439 0.9987 3087798 TimTec1_005793 COc1nsc(SC)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H08 compound treatment 40360.0 -9460.0 -0.16 42560.0 -704.0 -0.01 -0.1183 -0.756 1015156 TimTec1_005794 COc1ccc(Cl)cc1NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H09 compound treatment 19720.0 -30100.0 -0.5 18520.0 -24700.0 -0.39 -0.6302 -0.9935 1397048 TimTec1_005795 COc1cc2ccccc2cc1C(=O)NC(C)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H10 compound treatment 81520.0 31700.0 0.52 80760.0 37500.0 0.6 0.7926 0.9978 3087801 TimTec1_005796 CC1(C)CC(=O)C2=C(C1)N(C(=C(C#N)C2c3ccsc3)N)c4c(F)cccc4F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H11 compound treatment 80320.0 30500.0 0.5 93120.0 49900.0 0.79 0.9179 0.9758 1338227 TimTec1_005797 COc1ccc(NC(=O)c2cnn(c2NC(=O)c3ccccc3F)c4ccccc4)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H12 compound treatment 73320.0 23500.0 0.39 80560.0 37300.0 0.59 0.6947 0.9786 1493728 TimTec1_005798 C1Oc2ccc(cc2O1)c3cc4ccccn4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H13 compound treatment 63240.0 13400.0 0.22 69680.0 26400.0 0.42 0.4544 0.955 1440128 TimTec1_005799 COc1cc(NC(=O)NC2(CC2)c3ccccc3)c(OC)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H14 compound treatment 63800.0 14000.0 0.23 78240.0 35000.0 0.56 0.5574 0.9238 1272978 TimTec1_005800 Cc1cc(NS(=O)(=O)c2ccccc2)cc(c1O)S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H15 compound treatment 120040.0 70200.0 1.16 111720.0 68500.0 1.09 1.5912 0.9995 3211757 TimTec1_005801 Cc1cc(Cl)nc(NN)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H16 compound treatment 67000.0 17200.0 0.28 83720.0 40500.0 0.64 0.6565 0.932 1520603 TimTec1_005802 Cn1c2ccc(Br)cc2c3nnc(SCc4ccc5nonc5c4)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H17 compound treatment 91240.0 41400.0 0.68 96480.0 53200.0 0.85 1.0833 0.9943 1486800 TimTec1_005803 CN(C)CP(=O)(O)CCn1c2ccccc2c3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H18 compound treatment 111000.0 61200.0 1.01 101160.0 57900.0 0.92 1.3666 0.999 1194716 TimTec1_005804 OC(=O)C1Sc2c(sc(=O)n2Cc3ccccc3)C4C1C(=O)Oc5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H19 compound treatment 88880.0 39100.0 0.64 93960.0 50700.0 0.81 1.0273 0.9937 1203354 TimTec1_005805 Nc1nnc(CCCn2c(=O)oc3ccccc23)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H20 compound treatment 44600.0 -5220.0 -0.09 49880.0 6620.0 0.11 0.0137 0.1004 3087859 TimTec1_005806 CC/N=C\1/S/C(=C/c2ccc(o2)c3ccc(F)cc3)/C(=O)N1CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H21 compound treatment 55960.0 6140.0 0.1 49120.0 5860.0 0.09 0.1377 0.9991 1544104 TimTec1_005807 CN(C)c1ccc(cc1)C2OC(=O)C(C)(C)C(=O)C2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H22 compound treatment 51920.0 2100.0 0.03 58280.0 15000.0 0.24 0.1938 0.8013 3211853 TimTec1_005808 CCCn1c2ccccc2c3nnc(SCC(=O)NCc4ccc5OCOc5c4)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H23 mock treatment 84040.0 34200.0 0.56 83200.0 39900.0 0.64 0.8495 0.9982 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 H24 mock treatment 28080.0 -21700.0 -0.36 27600.0 -15700.0 -0.25 -0.4303 -0.9843 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I01 compound treatment 31760.0 -18100.0 -0.3 29800.0 -13500.0 -0.21 -0.3625 -0.987 1315061 TimTec1_005809 CCOC1(C)N(Nc2ccccc2C(=O)CC)c3ccccc3C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I02 compound treatment 48280.0 -1540.0 -0.03 58920.0 15700.0 0.25 0.1585 0.6319 1011005 TimTec1_005810 OC(=O)CSc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I03 compound treatment 51320.0 1500.0 0.02 57520.0 14300.0 0.23 0.1782 0.7797 3211854 TimTec1_005811 CC1(C)OC(=O)N(Nc2ccccc2)C1(C)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I04 compound treatment 23840.0 -26000.0 -0.43 24480.0 -18800.0 -0.3 -0.5149 -0.9846 3087863 TimTec1_005812 Cc1c(Cl)cccc1NN 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I05 compound treatment 72400.0 22600.0 0.37 74600.0 31300.0 0.5 0.6168 0.9896 1462704 TimTec1_005813 CC(C)(C)NC(=O)CSc1nc2ccc(cc2s1)N3C(=O)c4ccccc4C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I06 compound treatment 88640.0 38800.0 0.64 92440.0 49200.0 0.78 1.0074 0.995 1663326 TimTec1_005814 Cc1cc(C)n2nc(nc2n1)S(=O)(=O)Nc3ccccc3C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I07 compound treatment 24680.0 -25100.0 -0.41 30520.0 -12700.0 -0.2 -0.437 -0.946 3211855 TimTec1_005815 C1C/C(=C\c2nc3ccccc3[nH]2)/C(=C1)N4CCOCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I08 compound treatment 57360.0 7540.0 0.12 69160.0 25900.0 0.41 0.3799 0.8812 1375813 TimTec1_005816 CN(C)c1ccc(cc1)C2N(Cc3ccccc3)C(=O)C(=C2C(=O)c4ccc(Cl)cc4)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I09 compound treatment 7080.0 -42700.0 -0.71 7200.0 -36100.0 -0.57 -0.9053 -0.9948 3087867 TimTec1_005817 COC(=O)c1c(CSC(=N)N)nc2n(Cc3ccccc3)c4ccccc4n12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I10 compound treatment 79800.0 30000.0 0.49 84240.0 41000.0 0.65 0.8118 0.9906 3211856 TimTec1_005818 CC1=C(OC(=O)c2ccccc2)C(C)(C)C(OC1=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I11 compound treatment 108920.0 59100.0 0.98 111280.0 68000.0 1.08 1.4564 0.9986 3087868 TimTec1_005819 COC(=O)c1ccc(/N=C/2\SC(CC(=O)N2C)C(=O)O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I12 compound treatment 100080.0 50300.0 0.83 110240.0 67000.0 1.07 1.3415 0.9922 3211857 TimTec1_005820 COc1ccc(/C=N/c2nnc(c3ccccc3)c(n2)c4ccccc4)c(C(=O)O)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I13 compound treatment 13360.0 -36500.0 -0.6 21600.0 -21700.0 -0.35 -0.6697 -0.9652 3087871 TimTec1_005821 CC1CN(CN2C(=O)/C(=N\c3ccc4ccccc4c3)/c5ccccc25)CC(C)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I14 compound treatment 90720.0 40900.0 0.68 103800.0 60500.0 0.96 1.1597 0.9848 1190190 TimTec1_005822 CC(=O)OC1c2ccccc2NC(c3ccccc3)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I15 compound treatment 31680.0 -18100.0 -0.3 28320.0 -14900.0 -0.24 -0.3801 -0.9936 1442650 TimTec1_005823 COC(=O)C1=C(C)NC(=C(C#N)C1c2cccs2)SCC(=O)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I16 compound treatment 41200.0 -8620.0 -0.14 40840.0 -2420.0 -0.04 -0.1279 -0.8677 3087873 TimTec1_005824 SC1=C(C#N)C2(CCCCC2)C(C(=N)N1)c3nc(cs3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I17 compound treatment 66040.0 16200.0 0.27 63240.0 20000.0 0.32 0.4145 0.9963 1201213 TimTec1_005825 OC(=O)c1ccc(N=NN2CCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I18 compound treatment 42160.0 -7660.0 -0.13 38440.0 -4820.0 -0.08 -0.1437 -0.9716 3211858 TimTec1_005826 CSc1ccc(cc1)S(=O)(=O)Nc2ccc(N3CCOCC3)c(Cl)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I19 compound treatment 7600.0 -42200.0 -0.7 8880.0 -34400.0 -0.55 -0.8803 -0.9929 1656330 TimTec1_005827 CC(C)(CN1CCN(CC1)C(c2ccccc2)c3ccccc3)NS(=O)(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I20 compound treatment 59880.0 10100.0 0.17 62560.0 19300.0 0.31 0.3349 0.9582 1594685 TimTec1_005828 CC1C(C#N)(C#N)C2(C#N)C(OC1(C)OC2=N)c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I21 compound treatment 42680.0 -7140.0 -0.12 41000.0 -2260.0 -0.04 -0.1088 -0.8832 3211859 TimTec1_005829 O=C/1N(CN2CCN(CC2)c3ccccc3)c4ccccc4\C1=N\c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I22 compound treatment 32640.0 -17200.0 -0.28 28000.0 -15300.0 -0.24 -0.3725 -0.9971 1426903 TimTec1_005830 Nc1c(C#N)c(c(C#N)c2nc3ccccc3n12)c4cccc(O)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I23 mock treatment 58480.0 8660.0 0.14 51440.0 8180.0 0.13 0.1933 0.9989 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 I24 mock treatment 27120.0 -22700.0 -0.37 25000.0 -18300.0 -0.29 -0.4708 -0.9922 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J01 compound treatment 30840.0 -19000.0 -0.31 25880.0 -17400.0 -0.28 -0.4174 -0.9981 1380440 TimTec1_005831 CC(C)(CO)NC1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J02 compound treatment 2840.0 -47000.0 -0.78 3040.0 -40200.0 -0.64 -1.0017 -0.9955 1328534 TimTec1_005832 Clc1ccc(Cl)c(c1)S(=O)(=O)NCCC2(CC3CC4CC(C3)C2)C4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J03 compound treatment 36720.0 -13100.0 -0.22 29000.0 -14300.0 -0.23 -0.3136 -0.9997 3211860 TimTec1_005833 FC(F)(F)C1=CC(=NCCN1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J04 compound treatment 13560.0 -36300.0 -0.6 6040.0 -37200.0 -0.59 -0.8427 -1.0 1159735 TimTec1_005834 CN(C)P1(=O)Nc2ccccc2S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J05 compound treatment 80560.0 30700.0 0.51 78880.0 35600.0 0.57 0.7602 0.9984 1421447 TimTec1_005835 CC(C)(O)C1(C)NCCc2ccccc21 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J06 compound treatment 7880.0 -41900.0 -0.69 9640.0 -33600.0 -0.54 -0.8685 -0.992 1178221 TimTec1_005836 CC1CC2(CC(C)(C)C1)NN(C(=S)N2)c3ccc(C)c(C)c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J07 compound treatment 101240.0 51400.0 0.85 85320.0 42100.0 0.67 1.0742 0.9932 1709992 TimTec1_005837 CC1(C)CC(CC(C)(C)N1)NCc2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J08 compound treatment 85480.0 35700.0 0.59 90200.0 46900.0 0.75 0.9452 0.993 1603180 TimTec1_005838 O=C(NC1CCCCC1)C2CC(=O)OC32CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J09 compound treatment 53320.0 3500.0 0.06 57360.0 14100.0 0.22 0.1998 0.861 1526847 TimTec1_005839 Cc1ccc2c3C(C4=C(CCCC4=O)Nc3ccc2n1)c5ccccc5C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J10 compound treatment 89880.0 40100.0 0.66 86600.0 43300.0 0.69 0.956 0.9998 3211861 TimTec1_005840 CCc1nc2sc(C(=O)Nc3ccc(OC(F)(F)F)cc3)c(N)c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J11 compound treatment 73000.0 23200.0 0.38 71800.0 28500.0 0.45 0.5922 0.9963 1564041 TimTec1_005841 CCN(C(=O)Cn1nnc(n1)c2ccc3OCOc3c2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J12 compound treatment 104400.0 54600.0 0.9 99600.0 56300.0 0.9 1.272 1.0 3087925 TimTec1_005842 FC(F)(F)c1nnc2SCC(=Nn12)c3ccc(Cl)cc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J13 compound treatment 114000.0 64200.0 1.06 111400.0 68100.0 1.09 1.5171 0.9999 3211862 TimTec1_005843 CCN1C(=O)C2NN=C(C2C1=O)C(=O)c3nc(Cl)ccc3Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J14 compound treatment 75240.0 25400.0 0.42 71240.0 28000.0 0.45 0.612 0.9995 1209557 TimTec1_005844 COc1ccc(cc1)C(=O)Nc2cc(C)c(O)c(c2C)S(=O)(=O)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J15 compound treatment 13200.0 -36600.0 -0.6 21280.0 -22000.0 -0.35 -0.6752 -0.9664 3211863 TimTec1_005845 Sc1nc(SCCOc2ccccc2)nc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J16 compound treatment 61040.0 11200.0 0.19 80880.0 37600.0 0.6 0.5549 0.8843 3087928 TimTec1_005846 CC(C)(C)C(=O)/C=C/1\NCCN\C1=C/C(=O)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J17 compound treatment 77720.0 27900.0 0.46 97000.0 53700.0 0.86 0.9313 0.9577 1272266 TimTec1_005847 OC(=O)C(Cc1ccco1)P(=O)(O)CN2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J18 compound treatment 11400.0 -38400.0 -0.63 10960.0 -32300.0 -0.51 -0.8125 -0.9947 1688384 TimTec1_005848 O=C(Nc1ccccc1)c2cccc(c2)S(=O)(=O)NCC3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J19 compound treatment 90280.0 40500.0 0.67 90800.0 47500.0 0.76 1.008 0.998 1696945 TimTec1_005849 COc1cccc(c1)C(=O)Nc2cccc(C)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J20 compound treatment 29160.0 -20700.0 -0.34 33440.0 -9820.0 -0.16 -0.3518 -0.9377 3087931 TimTec1_005850 Cc1cccn2cc(cc12)c3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J21 compound treatment 84840.0 35000.0 0.58 85080.0 41800.0 0.67 0.8801 0.9975 1142933 TimTec1_005851 Cc1ccc(cc1)C(=O)C2OC(=O)C(C)(C)C(=O)C2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J22 compound treatment 33000.0 -16800.0 -0.28 22200.0 -21100.0 -0.34 -0.4337 -0.9955 3211864 TimTec1_005852 COc1cccc2cc(C(=O)NCCc3c(C)[nH]c4ccc(OC(F)(F)F)cc34)c(=O)oc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J23 mock treatment 58600.0 8780.0 0.14 47240.0 3980.0 0.06 0.1473 0.9311 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 J24 mock treatment 45520.0 -4300.0 -0.07 31760.0 -11500.0 -0.18 -0.1798 -0.9146 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K01 compound treatment 2120.0 -47700.0 -0.79 1760.0 -41500.0 -0.66 -1.0245 -0.9962 1683560 TimTec1_005853 CCn1c(nc2ccccc12)C(O)c3cc(c(O)c(c3)C(C)(C)C)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K02 compound treatment 33360.0 -16500.0 -0.27 30560.0 -12700.0 -0.2 -0.3353 -0.9895 3088026 TimTec1_005854 O=C1CSC2=NCN(CN12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K03 compound treatment 19120.0 -30700.0 -0.51 16720.0 -26500.0 -0.42 -0.6575 -0.996 3087964 TimTec1_005855 CCOC(=O)C1=C(C)NC(=NC1c2ccc(OC(=O)C)c(OC)c2)SC(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K04 compound treatment 68720.0 18900.0 0.31 63720.0 20500.0 0.33 0.4512 0.9998 3087966 TimTec1_005856 CC(=O)NCCOc1cccc2cccnc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K05 compound treatment 66080.0 16300.0 0.27 58360.0 15100.0 0.24 0.36 0.9985 1264565 TimTec1_005857 Cn1c(SCc2ccc(F)c3ccccc23)nc4ccccc4c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K06 compound treatment 47600.0 -2220.0 -0.04 47760.0 4500.0 0.07 0.0248 0.3081 3211865 TimTec1_005858 Clc1ccc(/N=C/2\C(=O)N(CN3CCc4ccccc4C3)c5ccccc25)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K07 compound treatment 72120.0 22300.0 0.37 74640.0 31400.0 0.5 0.6139 0.9887 1638757 TimTec1_005859 CCN(CC)P1(=O)COc2ccccc2OC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K08 compound treatment 18400.0 -31400.0 -0.52 23880.0 -19400.0 -0.31 -0.5852 -0.9694 3211945 TimTec1_005860 CCC1CCC2(CC1)SCC(=O)N2c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K09 compound treatment 67600.0 17800.0 0.29 72840.0 29600.0 0.47 0.5409 0.974 1385466 TimTec1_005861 COc1ccc(cc1)N(C)C(=O)C2COc3ccccc3O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K10 compound treatment 68000.0 18200.0 0.3 65000.0 21700.0 0.35 0.4572 0.9974 1301245 TimTec1_005862 Cc1ccc(NS(=O)(=O)c2c(C)ccc3nsnc23)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K11 compound treatment 98480.0 48700.0 0.8 103800.0 60500.0 0.96 1.2503 0.9959 3087971 TimTec1_005863 CN(C)/C=N\c1ccc2nonc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K12 compound treatment 45480.0 -4340.0 -0.07 58160.0 14900.0 0.24 0.1173 0.4728 1432844 TimTec1_005864 CCOC(=O)c1c(CN2CCCC2)n(C)c3cc(Br)c(OC)cc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K13 compound treatment 75280.0 25500.0 0.42 72280.0 29000.0 0.46 0.6242 0.9989 3211946 TimTec1_005865 CSC1=NC2(CC(Oc3cc(O)ccc32)c4ccccc4)CC(C)(C)N1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K14 compound treatment 118120.0 68300.0 1.13 117760.0 74500.0 1.19 1.6368 0.9997 3087973 TimTec1_005866 CC(=O)N1C(=O)/C(=C\c2cccnc2)/NC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K15 compound treatment 5200.0 -44600.0 -0.74 4760.0 -38500.0 -0.61 -0.9547 -0.9959 1685221 TimTec1_005867 CCOC(=O)c1c(NC(=O)CSc2nccn2C)sc3CC(C)CCc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K16 compound treatment 3920.0 -45900.0 -0.76 4400.0 -38900.0 -0.62 -0.9737 -0.995 3087975 TimTec1_005868 Oc1ccccc1c2cc(nn2Cc3ccc(Cl)cc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K17 compound treatment 52080.0 2260.0 0.04 35040.0 -8220.0 -0.13 -0.0663 -0.4863 1551420 TimTec1_005869 COC(=O)c1ccc(N=NN2CCCCCC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K18 compound treatment 60360.0 10500.0 0.17 55640.0 12400.0 0.2 0.2625 0.998 1545682 TimTec1_005870 COc1ccc(cc1)C2CC(=O)Oc3ccc(cc23)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K19 compound treatment 39520.0 -10300.0 -0.17 38120.0 -5140.0 -0.08 -0.1782 -0.9441 1253632 TimTec1_005871 O=C(N(Cc1ccccc1)c2ccccn2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K20 compound treatment 39120.0 -10700.0 -0.18 53480.0 10200.0 0.16 -0.0097 -0.0405 3211947 TimTec1_005872 COc1nc(OC)nc(n1)n2cnc(NC(=O)Nc3cccc(Cl)c3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K21 compound treatment 30840.0 -19000.0 -0.31 28480.0 -14800.0 -0.24 -0.3881 -0.9901 1118061 TimTec1_005873 Sc1nc2-c3ccccc3CC(C4CCCCC4)c2c(=O)[nH]1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K22 compound treatment 4640.0 -45200.0 -0.75 4000.0 -39300.0 -0.63 -0.9698 -0.9962 3211948 TimTec1_005874 CCC(C#N)C1(CC2CC3CC(C2)C1)C3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K23 mock treatment 46240.0 -3580.0 -0.06 62520.0 19300.0 0.31 0.1753 0.5608 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 K24 mock treatment 22360.0 -27500.0 -0.45 26760.0 -16500.0 -0.26 -0.5065 -0.9665 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L01 compound treatment 26120.0 -23700.0 -0.39 23800.0 -19500.0 -0.31 -0.496 -0.9934 3087980 TimTec1_005875 COC(=O)c1ccc(cc1)C2OCC(C)(C)CO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L02 compound treatment 19240.0 -30600.0 -0.5 13960.0 -29300.0 -0.47 -0.6872 -0.9992 1135137 TimTec1_005876 CCOc1ccc(CCNS(=O)(=O)c2c(C)cc(C)cc2C)cc1OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L03 compound treatment 30920.0 -18900.0 -0.31 24680.0 -18600.0 -0.3 -0.43 -0.9997 3211949 TimTec1_005877 COc1ccc(CN/2C(=O)CC(S\C2=N/c3ccccc3)C(=O)N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L04 compound treatment 3480.0 -46300.0 -0.76 3520.0 -39700.0 -0.63 -0.9888 -0.9956 1515423 TimTec1_005878 CCOc1nc(Cl)nc(n1)N2CCCCC2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L05 compound treatment 60680.0 10900.0 0.18 69000.0 25700.0 0.41 0.4168 0.9311 3088028 TimTec1_005879 COc1ccc(cc1)C(=O)NC(N2CCCCC2c3cccnc3)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L06 compound treatment 83880.0 34100.0 0.56 74040.0 30800.0 0.49 0.7444 0.9977 1732675 TimTec1_005880 CCOc1ccc(CC(=O)Nc2ccccc2)cc1OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L07 compound treatment 39400.0 -10400.0 -0.17 35800.0 -7460.0 -0.12 -0.2057 -0.9838 1230635 TimTec1_005881 Cc1ccc2c3C(C4=C(CCCC4=O)Nc3ccc2n1)c5ccc(O)cc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L08 compound treatment 57960.0 8140.0 0.13 86480.0 43200.0 0.69 0.5821 0.8294 1233176 TimTec1_005882 CCNC(=O)C1CC(=O)OC21CCCCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L09 compound treatment 83600.0 33800.0 0.56 69360.0 26100.0 0.42 0.6884 0.9896 1157682 TimTec1_005883 COCc1cc(C)nc(SCC(=O)N2CCCCC2)c1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L10 compound treatment 72200.0 22400.0 0.37 77440.0 34200.0 0.54 0.6464 0.9821 3088032 TimTec1_005884 CC(=O)ON1C(C)(C)C=C(C(=O)N)C1(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L11 compound treatment 48280.0 -1540.0 -0.03 46800.0 3540.0 0.06 0.0219 0.3544 3211950 TimTec1_005885 COc1ccccc1n2c(S)nnc2Cc3ccc(Cl)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L12 compound treatment 72520.0 22700.0 0.37 89240.0 46000.0 0.73 0.7832 0.9515 1274328 TimTec1_005886 COc1ccccc1C2C3=C(CCCC3=O)Nc4ccc5ncccc5c24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L13 compound treatment 64680.0 14900.0 0.25 61640.0 18400.0 0.29 0.3806 0.9961 3211951 TimTec1_005887 COC(=O)C1=CN(CC2(CC3CC4CC(C3)C2)C4)C=C(C1c5ccc(F)cc5)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L14 compound treatment 58080.0 8260.0 0.14 52640.0 9380.0 0.15 0.2021 0.999 1513069 TimTec1_005888 CC(C)c1c(NC(=O)c2ccc(Cl)cc2)cc(C)c(O)c1S(=O)(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L15 compound treatment 46800.0 -3020.0 -0.05 51440.0 8180.0 0.13 0.0569 0.408 1273520 TimTec1_005889 CCn1c(SCCn2c(=S)n(C)c3ccccc23)nc4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L16 compound treatment 31160.0 -18700.0 -0.31 40520.0 -2740.0 -0.04 -0.2487 -0.7995 1715744 TimTec1_005890 C(N1CCCC1)c2cc3ccccc3c4COCc42 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L17 compound treatment 12560.0 -37300.0 -0.62 8880.0 -34400.0 -0.55 -0.8224 -0.9983 1402014 TimTec1_005891 Cc1nc2cccc(C(=O)Oc3ccc(cc3)C(C)(C)C)c2o1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L18 compound treatment 4320.0 -45500.0 -0.75 3800.0 -39500.0 -0.63 -0.9758 -0.9961 1594146 TimTec1_005892 O=C(Nc1ccccc1)c2cccc(c2)S(=O)(=O)NCCC3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L19 compound treatment 59520.0 9700.0 0.16 65360.0 22100.0 0.35 0.3623 0.9364 3088038 TimTec1_005893 CCc1nnc(NC(=O)CSc2nnc(c3cccs3)n2CC=C)s1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L20 compound treatment 10880.0 -38900.0 -0.64 5440.0 -37800.0 -0.6 -0.8808 -0.9995 3211952 TimTec1_005894 CCN(CC)c1ccc(C=C2C(=O)OC(OC2=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L21 compound treatment 46800.0 -3020.0 -0.05 52320.0 9060.0 0.14 0.0668 0.4378 3088039 TimTec1_005895 OC(=O)/C(=C/C(=O)c1ccccc1)/Nc2ccc(OC(F)(F)F)cc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L22 compound treatment 41320.0 -8500.0 -0.14 38280.0 -4980.0 -0.08 -0.1554 -0.9637 1788194 TimTec1_005896 CCOC(=O)c1c(C)c(NC(=O)C)c(C)n1C(=O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L23 mock treatment 38320.0 -11500.0 -0.19 32920.0 -10300.0 -0.16 -0.2508 -0.9975 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 L24 mock treatment 19240.0 -30600.0 -0.5 26920.0 -16300.0 -0.26 -0.5411 -0.9526 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M01 compound treatment 16400.0 -33400.0 -0.55 10440.0 -32800.0 -0.52 -0.76 -0.9996 1430182 TimTec1_005897 Cc1cc(NC(=O)c2cccc(c2)S(=O)(=O)Nc3ccc(C)cc3)no1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M02 compound treatment 38240.0 -11600.0 -0.19 29440.0 -13800.0 -0.22 -0.2909 -0.9975 1516860 TimTec1_005898 CCN1C2OC3OC4C(OC3OC2N(CC)S1(=O)=O)N(CC)S(=O)(=O)N4CC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M03 compound treatment 25320.0 -24500.0 -0.4 21920.0 -21300.0 -0.34 -0.5265 -0.9963 1315988 TimTec1_005899 Clc1ccccc1NCn2nc(c3ccccc3)n(CC=C)c2=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M04 compound treatment 49560.0 -258.0 0.0 26240.0 -17000.0 -0.27 -0.1949 -0.7181 3088042 TimTec1_005900 CCC(=O)NC(Nc1sc(C)c(CC)c1C#N)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M05 compound treatment 42360.0 -7460.0 -0.12 39880.0 -3380.0 -0.05 -0.1252 -0.9314 3211953 TimTec1_005901 CC(C)C1C(=C(N)Oc2n[nH]c(C)c12)C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M06 compound treatment 37800.0 -12000.0 -0.2 21760.0 -21500.0 -0.34 -0.3826 -0.9662 1171314 TimTec1_005902 COc1ccc(OC)c(CNc2ccc3n(C)c(C)nc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M07 compound treatment 30160.0 -19700.0 -0.32 21120.0 -22100.0 -0.35 -0.479 -0.9991 3088045 TimTec1_005903 CCOC(=O)C1=C(C)NC(=NC1c2ccccc2)SCC(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M08 compound treatment 4320.0 -45500.0 -0.75 4080.0 -39200.0 -0.62 -0.9727 -0.9958 1705094 TimTec1_005904 OC(=O)Cc1c(Sc2ccccc2)c3ccccc3n1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M09 compound treatment 24080.0 -25700.0 -0.42 21640.0 -21600.0 -0.34 -0.5441 -0.9946 3211954 TimTec1_005905 CN(C)c1ccc(/C=C/2\C(=O)N(N=C2C(=O)Nc3ccccc3)c4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M10 compound treatment 11520.0 -38300.0 -0.63 10160.0 -33100.0 -0.53 -0.8201 -0.996 1621165 TimTec1_005906 O1c2ccccc2N=C(c3ccccc3)c4ccccc14 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M11 compound treatment 40160.0 -9660.0 -0.16 31760.0 -11500.0 -0.18 -0.2424 -0.9976 1640716 TimTec1_005907 CCN(CC)C(=O)c1cn(nc1C2(CC3CC4CC(C3)C2)C4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M12 compound treatment 75840.0 26000.0 0.43 65280.0 22000.0 0.35 0.5519 0.995 3211955 TimTec1_005908 OC(=O)C1CC(=O)N(CCc2ccccc2)/C(=N/CCc3ccccc3)/S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M13 compound treatment 20320.0 -29500.0 -0.49 11840.0 -31400.0 -0.5 -0.6985 -0.9999 3088114 TimTec1_005909 CCCN1C(=O)/C(=C/C=C\2/Sc3ccccc3N2CCO)/SC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M14 compound treatment 16200.0 -33600.0 -0.55 9720.0 -33500.0 -0.53 -0.7704 -0.9998 1416853 TimTec1_005910 CCCCC(=O)Nc1ccc(cc1)c2csc(n2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M15 compound treatment 14320.0 -35500.0 -0.59 7120.0 -36100.0 -0.58 -0.8217 -1.0 3088116 TimTec1_005911 FC(F)(F)c1cccc(/N=C/2\C(=O)N(CN3CCc4ccccc4C3)c5ccccc25)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M16 compound treatment 33840.0 -16000.0 -0.26 19280.0 -24000.0 -0.38 -0.4568 -0.9836 1117685 TimTec1_005912 CN(C)c1ccc(cc1)C2OC(COc3ccccc3)CN(O2)C(=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M17 compound treatment 38560.0 -11300.0 -0.19 28680.0 -14600.0 -0.23 -0.2958 -0.9938 1411622 TimTec1_005913 O=C(N(c1ccccc1)c2ccccc2)c3ccccc3C(=O)N4CCCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M18 compound treatment 27560.0 -22300.0 -0.37 21920.0 -21300.0 -0.34 -0.5003 -0.9993 1119974 TimTec1_005914 COc1ccc(cc1)c2nc(SCc3ccccc3C#N)[nH]c(=O)c2C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M19 compound treatment 31480.0 -18300.0 -0.3 24400.0 -18900.0 -0.3 -0.4266 -1.0 1518985 TimTec1_005915 CC(C1C(=C(N)Oc2c1c(=O)oc3ccccc23)C#N)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M20 compound treatment 67880.0 18100.0 0.3 43680.0 416.0 0.01 0.2155 0.7227 3088119 TimTec1_005916 FC(F)(F)c1ccc(cc1)C(=O)Nc2cccc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M21 compound treatment 56000.0 6180.0 0.1 34960.0 -8300.0 -0.13 -0.0214 -0.1282 1232476 TimTec1_005917 CC1CN(C(=O)C)c2ccccc2NC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M22 compound treatment 50960.0 1140.0 0.02 24760.0 -18500.0 -0.29 -0.1952 -0.6605 1452888 TimTec1_005918 O=C1N(C(=O)c2cccc3cccc1c23)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M23 mock treatment 36680.0 -13100.0 -0.22 19240.0 -24000.0 -0.38 -0.4241 -0.9638 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 M24 mock treatment 23560.0 -26300.0 -0.43 12120.0 -31100.0 -0.5 -0.6575 -0.9977 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N01 compound treatment 5080.0 -44700.0 -0.74 1520.0 -41700.0 -0.67 -0.9927 -0.9986 1241281 TimTec1_005919 COc1cc(NC(=O)c2cc3ccccc3cc2OCC(=O)NC(C)(C)C)c(OC)cc1Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N02 compound treatment 33920.0 -15900.0 -0.26 17360.0 -25900.0 -0.41 -0.4775 -0.9761 3088122 TimTec1_005920 CCn/1cccc\c1=N/P2(=S)OCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N03 compound treatment 23000.0 -26800.0 -0.44 13880.0 -29400.0 -0.47 -0.6442 -0.9996 1595949 TimTec1_005921 OC1=C(C(N(CCc2ccccc2)C1=O)c3ccccc3)C(=O)c4cccs4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N04 compound treatment 43920.0 -5900.0 -0.1 19760.0 -23500.0 -0.37 -0.3337 -0.8622 1572095 TimTec1_005922 COCc1cc(C)nc2[nH]nc(N)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N05 compound treatment 30000.0 -19800.0 -0.33 14120.0 -29100.0 -0.46 -0.5598 -0.9853 3212011 TimTec1_005923 O=C(NCCOc1ccccc1)/C=C/c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N06 compound treatment 53120.0 3300.0 0.05 28320.0 -14900.0 -0.24 -0.1299 -0.5315 3212012 TimTec1_005924 CCOC(=O)c1cn(nc1N)C2CC(=O)C3OCC2O3.CCOC(=O)c1cn(nc1N)C2CC(O)(O)C3OCC2O3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N07 compound treatment 34120.0 -15700.0 -0.26 19560.0 -23700.0 -0.38 -0.4504 -0.9831 3088126 TimTec1_005925 NC[C@@H]1CCCN2CCCC[C@H]12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N08 compound treatment 31080.0 -18700.0 -0.31 22920.0 -20300.0 -0.32 -0.448 -0.9997 1354761 TimTec1_005926 CCC(C)NCc1ccc(o1)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N09 compound treatment 54040.0 4220.0 0.07 28440.0 -14800.0 -0.24 -0.1178 -0.4781 1518220 TimTec1_005927 CSC1=NC(=C(C(=O)Nc2ccccc2)C3(CCCCC3)C1C(=O)N)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N10 compound treatment 18600.0 -31200.0 -0.52 10240.0 -33000.0 -0.53 -0.7366 -0.9999 3212013 TimTec1_005928 OC1(O)CC(C2COC1O2)n3nc(c4ccco4)n(CC=C)c3=S.C=CCn1c(nn(C2CC(=O)C3OCC2O3)c1=S)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N11 compound treatment 29720.0 -20100.0 -0.33 11480.0 -31800.0 -0.51 -0.5928 -0.9789 3088130 TimTec1_005929 Cc1cc2CC(C)(C)N/C(=C/C(=O)N)/c2cc1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N12 compound treatment 67480.0 17700.0 0.29 56400.0 13100.0 0.21 0.3542 0.9868 1138138 TimTec1_005930 CCOC(=O)c1[nH]c(C)c(CNc2ccccc2)c1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N13 compound treatment 93760.0 43900.0 0.73 65120.0 21900.0 0.35 0.7592 0.9435 1675612 TimTec1_005931 COc1nonc1n2nnc(C(=O)c3ccccc3)c2C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N14 compound treatment 60640.0 10800.0 0.18 46120.0 2860.0 0.05 0.1585 0.8598 1140939 TimTec1_005932 CCCc1c(C)[nH]c2nc3ccccc3n2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N15 compound treatment 51720.0 1900.0 0.03 30080.0 -13200.0 -0.21 -0.1264 -0.5948 3088132 TimTec1_005933 Clc1ccccc1c2nnc3cccc(Cl)n23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N16 compound treatment 6520.0 -43300.0 -0.71 3280.0 -40000.0 -0.64 -0.956 -0.9984 1219341 TimTec1_005934 CCN(C(=O)c1c(C)c(Cl)c(C)nc1Oc2ccc(F)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N17 compound treatment 31920.0 -17900.0 -0.3 13360.0 -29900.0 -0.48 -0.5459 -0.9736 1518508 TimTec1_005935 CC(=O)N(CC1(CC2CC3CC(C2)C1)C3)C4CC(=O)N(C4=O)c5cccc(Cl)c5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N18 compound treatment 29440.0 -20400.0 -0.34 13160.0 -30100.0 -0.48 -0.5771 -0.9849 3088204 TimTec1_005936 Cn1nc(cc1Cl)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N19 compound treatment 31120.0 -18700.0 -0.31 18600.0 -24700.0 -0.39 -0.4962 -0.9928 3088206 TimTec1_005937 Cc1ccc(N/C(=C/C(=O)c2ccccc2)/C(=O)O)cc1Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N20 compound treatment 25680.0 -24100.0 -0.4 14120.0 -29100.0 -0.46 -0.6102 -0.9971 3088207 TimTec1_005938 CC(C)(C)C1(C)OC(=O)C(=Cc2ccc(Br)o2)C(=O)O1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N21 compound treatment 35960.0 -13900.0 -0.23 20840.0 -22400.0 -0.36 -0.4145 -0.9767 3212014 TimTec1_005939 COCCN1C=C(C(C(=C1)C(=O)OC)c2cccs2)C(=O)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N22 compound treatment 32560.0 -17300.0 -0.28 23720.0 -19500.0 -0.31 -0.4217 -0.999 3212015 TimTec1_005940 CN/1CCC\C1=C\C=C\2/SC(=S)NC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N23 mock treatment 23880.0 -25900.0 -0.43 15000.0 -28300.0 -0.45 -0.6213 -0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 N24 mock treatment 28000.0 -21800.0 -0.36 15520.0 -27700.0 -0.44 -0.5673 -0.9948 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O01 compound treatment 19640.0 -30200.0 -0.5 18480.0 -24800.0 -0.4 -0.6316 -0.9934 1199249 TimTec1_005941 CCCn1c2ccccc2c3nnc(SCC(=O)NC(C)c4ccccc4)nc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O02 compound treatment 39920.0 -9900.0 -0.16 34440.0 -8820.0 -0.14 -0.215 -0.9972 1786664 TimTec1_005942 CC(C)c1cc(=O)n2nc(N)[nH]c2n1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O03 compound treatment 27640.0 -22200.0 -0.37 22200.0 -21100.0 -0.34 -0.4963 -0.9991 3212016 TimTec1_005943 Fc1ccccc1COc2ccccc2/C=C\3/SC(=N)NC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O04 compound treatment 30360.0 -19500.0 -0.32 26160.0 -17100.0 -0.27 -0.4199 -0.9967 1724360 TimTec1_005944 c1c(nc2nc(c3ccccc3)c(nn12)c4ccccc4)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O05 compound treatment 25960.0 -23900.0 -0.39 26080.0 -17200.0 -0.27 -0.4721 -0.9842 3088212 TimTec1_005945 O=C(CSC1=NC(CC(=O)N1)c2ccccc2)Nc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O06 compound treatment 22120.0 -27700.0 -0.46 24960.0 -18300.0 -0.29 -0.5296 -0.9765 1025381 TimTec1_005946 COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O07 compound treatment 2120.0 -47700.0 -0.79 2280.0 -41000.0 -0.65 -1.0186 -0.9957 1512733 TimTec1_005947 COc1ccc(cc1)C2=C(C)C(c3cccs3)c4ccccc4O2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O08 compound treatment 22280.0 -27500.0 -0.45 24640.0 -18600.0 -0.3 -0.5313 -0.9787 3088214 TimTec1_005948 COC(=O)c1ccc(cc1)C2OCCCO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O09 compound treatment 20520.0 -29300.0 -0.48 13800.0 -29500.0 -0.47 -0.674 -0.9999 3212017 TimTec1_005949 CCN(CC)N=Nc1n[nH]c2nc(C)cc(C)c12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O10 compound treatment 31520.0 -18300.0 -0.3 27640.0 -15600.0 -0.25 -0.3897 -0.9954 1112286 TimTec1_005950 CC(=O)Nc1ccc(Cl)cc1C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O11 compound treatment 7720.0 -42100.0 -0.69 6480.0 -36800.0 -0.59 -0.9059 -0.9964 3212018 TimTec1_005951 C1C(=CC(=NN=C1c2ccccc2)c3ccccc3)c4c[nH]c5ccccc45 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O12 compound treatment 43440.0 -6380.0 -0.11 40760.0 -2500.0 -0.04 -0.1027 -0.9118 3212019 TimTec1_005952 COc1cc(OC)c(/C=C/2\C(=O)NC(=O)N(C3CCCCC3)C2=O)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O13 compound treatment 71760.0 21900.0 0.36 60280.0 17000.0 0.27 0.4479 0.9898 1583863 TimTec1_005953 CCOC(=O)C1(CCN(Cc2cccc(c2)C(=O)O)CC1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O14 compound treatment 52160.0 2340.0 0.04 38280.0 -4980.0 -0.08 -0.0288 -0.3263 3212020 TimTec1_005954 COC(=O)c1c(NC(NC(=O)C)(C(F)(F)F)C(F)(F)F)sc2CN(C)CCc12 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O15 compound treatment 18320.0 -31500.0 -0.52 17040.0 -26200.0 -0.42 -0.6632 -0.9941 1330742 TimTec1_005955 COc1ccc(cc1)C(=O)c2sc3nc(cc(c4cccs4)c3c2N)c5cccs5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O16 compound treatment 8920.0 -40900.0 -0.68 9800.0 -33500.0 -0.53 -0.8545 -0.9932 1008206 TimTec1_005956 NNc1ccc(Br)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O17 compound treatment 32960.0 -16900.0 -0.28 29040.0 -14200.0 -0.23 -0.3571 -0.9948 3212021 TimTec1_005957 C/N=C\1/S/C(=C\c2sccc2C)/C(=O)N1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O18 compound treatment 29520.0 -20300.0 -0.34 21800.0 -21500.0 -0.34 -0.4788 -0.9999 1627835 TimTec1_005958 OC(C(=O)NN1CCCCC1)(c2ccsc2)c3ccsc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O19 compound treatment 2160.0 -47700.0 -0.79 1720.0 -41500.0 -0.66 -1.0245 -0.9963 3088220 TimTec1_005959 C/C(=N/O)/C1CCCCCCCCCCC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O20 compound treatment 24040.0 -25800.0 -0.43 26320.0 -16900.0 -0.27 -0.4918 -0.9759 3212022 TimTec1_005960 Fc1cccc(C(=O)N2CCCCC2)c1F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O21 compound treatment 29520.0 -20300.0 -0.34 28920.0 -14300.0 -0.23 -0.3986 -0.9826 1373583 TimTec1_005961 Clc1ccc(cc1)C2(CC(=O)N3CCCCC3)C(=O)c4ccccc4C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O22 compound treatment 29440.0 -20400.0 -0.34 28480.0 -14800.0 -0.24 -0.4045 -0.9848 1018702 TimTec1_005962 Oc1ccccc1C(=O)N2CCOCC2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O23 mock treatment 38320.0 -11500.0 -0.19 39880.0 -3380.0 -0.05 -0.1723 -0.8735 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 O24 mock treatment 32920.0 -16900.0 -0.28 35000.0 -8260.0 -0.13 -0.2904 -0.9413 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P01 compound treatment 1040.0 -48800.0 -0.81 1800.0 -41500.0 -0.66 -1.0367 -0.9952 1707498 TimTec1_005963 COc1ccc(C(=O)c2ccccc2)c(OCC(=O)NC3(CC4CC5CC(C4)C3)C5)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P02 compound treatment 28000.0 -21800.0 -0.36 28680.0 -14600.0 -0.23 -0.419 -0.9776 3088297 TimTec1_005964 CC1(C)COP(=S)(OC1)N(C2=NCCC2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P03 compound treatment 28320.0 -21500.0 -0.35 32400.0 -10900.0 -0.17 -0.3734 -0.9456 3212023 TimTec1_005965 CCC1CC(O)C(C)C(C)S1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P04 compound treatment 1640.0 -48200.0 -0.8 1240.0 -42000.0 -0.67 -1.036 -0.9964 3088299 TimTec1_005966 Oc1c(Cl)cc(Cl)cc1C(O)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P05 compound treatment 19240.0 -30600.0 -0.5 16520.0 -26700.0 -0.43 -0.6583 -0.9965 1497087 TimTec1_005967 COc1ccccc1n2c(CSc3ccccn3)nc4ccccc4c2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P06 compound treatment 7680.0 -42100.0 -0.7 7880.0 -35400.0 -0.56 -0.8906 -0.9946 3088301 TimTec1_005968 FC(F)(F)c1ccc(cc1)C(=O)NCCc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P07 compound treatment 3560.0 -46300.0 -0.76 3000.0 -40300.0 -0.64 -0.9937 -0.9963 3212024 TimTec1_005969 Brc1cccc(CSCC(=O)Nc2ccc3ccccc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P08 compound treatment 27560.0 -22300.0 -0.37 18080.0 -25200.0 -0.4 -0.5436 -0.999 3212086 TimTec1_005970 Cc1cc(Cl)ccc1OC2C(N(C2=O)c3cccc(c3)C(F)(F)F)c4ccc5OCOc5c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P09 compound treatment 20720.0 -29100.0 -0.48 20960.0 -22300.0 -0.36 -0.591 -0.989 1275002 TimTec1_005971 CC(NC(=O)NC1(CC1)c2ccccc2)C3(CC4CC5CC(C4)C3)C5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P10 compound treatment 22920.0 -26900.0 -0.44 22800.0 -20500.0 -0.33 -0.5446 -0.9885 1579554 TimTec1_005972 COc1ccc(cc1OC)C2SCC(=O)N2CCN3CCCCC3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P11 compound treatment 2640.0 -47200.0 -0.78 5360.0 -37900.0 -0.6 -0.9779 -0.9921 3088305 TimTec1_005973 CNc1nc(cc(n1)C(F)(F)F)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P12 compound treatment 47280.0 -2540.0 -0.04 43640.0 376.0 0.01 -0.0254 -0.5998 1420064 TimTec1_005974 Fc1ccccc1c2nnn(CC(=O)NCc3ccc4OCOc4c3)n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P13 compound treatment 29160.0 -20700.0 -0.34 24800.0 -18500.0 -0.29 -0.4492 -0.9973 1669226 TimTec1_005975 CCOC(=O)C1=C(N)CC(NC1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P14 compound treatment 42560.0 -7260.0 -0.12 38520.0 -4740.0 -0.08 -0.1382 -0.9754 3088307 TimTec1_005976 COc1cc(ccc1n2cnnn2)n3cnnn3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P15 compound treatment 31560.0 -18300.0 -0.3 21080.0 -22200.0 -0.35 -0.4631 -0.9968 1638981 TimTec1_005977 COc1ccc(NC(=O)C2(CCCCC2)N(C(=O)Cn3nnnc3N)c4ccc(OC)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P16 compound treatment 29840.0 -20000.0 -0.33 26320.0 -16900.0 -0.27 -0.4241 -0.9951 1387660 TimTec1_005978 CN(C)c1ccc(cc1)C(N2C(CC2=O)c3ccco3)C(=O)Nc4c(C)cccc4C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P17 compound treatment 32120.0 -17700.0 -0.29 27240.0 -16000.0 -0.26 -0.3872 -0.9978 1166206 TimTec1_005979 Cc1cc(C)n2nc(nc2n1)S(=O)(=O)N(CC=C)CC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P18 compound treatment 9280.0 -40500.0 -0.67 11200.0 -32100.0 -0.51 -0.8345 -0.9911 3088310 TimTec1_005980 Cc1ccccc1CSc2nnc3c4ccccc4n(CC=C)c3n2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P19 compound treatment 5600.0 -44200.0 -0.73 2440.0 -40800.0 -0.65 -0.9762 -0.9984 3212087 TimTec1_005981 CC(=O)NC(NCC1(CC2CC3CC(C2)C1)C3)(C(F)(F)F)C(F)(F)F 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P20 compound treatment 23480.0 -26300.0 -0.43 32800.0 -10500.0 -0.17 -0.4254 -0.9135 3212088 TimTec1_005982 Brc1ccc2nc(oc(=O)c2c1)c3ccc4C(=O)N(C5CCCCC5)C(=O)c4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P21 compound treatment 11160.0 -38700.0 -0.64 10200.0 -33100.0 -0.53 -0.8239 -0.9955 1700737 TimTec1_005983 Cc1ccc(cc1S(=O)(=O)NCc2ccccn2)c3nnc(Nc4ccccc4)c5ccccc35 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P22 compound treatment 18880.0 -30900.0 -0.51 20200.0 -23100.0 -0.37 -0.621 -0.987 3212089 TimTec1_005984 CN1CCC(CC1)OC(=O)c2cc3cc(Br)ccc3oc2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P23 mock treatment 30320.0 -19500.0 -0.32 30080.0 -13200.0 -0.21 -0.3762 -0.9787 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2079 P24 mock treatment 36120.0 -13700.0 -0.23 41240.0 -2020.0 -0.03 -0.1827 -0.7999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A01 compound treatment 28520.0 -56100.0 -0.93 45880.0 -29000.0 -0.46 -0.9825 -0.9485 3561840 PK04_181001 CC(C)(C)N(CC=C)C(=O)C1N(Cc2ccccc2)C(=O)C3C(C4OC13C=C4)C(=O)O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A02 compound treatment 9360.0 -75300.0 -1.24 8880.0 -66000.0 -1.05 -1.6231 -0.9966 3561841 PK04_181002 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A03 compound treatment 74520.0 -10100.0 -0.17 38280.0 -36600.0 -0.58 -0.5312 -0.8747 3561843 PK04_181003 OC1CCC(CC1)N2C(C(=O)N(CC=C)c3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A04 compound treatment 65880.0 -18800.0 -0.31 25920.0 -49000.0 -0.78 -0.7714 -0.9182 2065615 PK04_181004 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A05 compound treatment 83560.0 -1110.0 -0.02 23280.0 -51600.0 -0.82 -0.5948 -0.7227 3561844 PK04_181005 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccco4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A06 compound treatment 46840.0 -37800.0 -0.62 11640.0 -63300.0 -1.01 -1.1546 -0.9735 3561845 PK04_181006 CCCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)c5ccccc5Cl)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A07 compound treatment 173760.0 89100.0 1.47 25440.0 -49500.0 -0.79 0.4824 0.2891 3561847 PK04_181007 Cc1cccc2OC(CC(=O)c12)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A08 compound treatment 101080.0 16400.0 0.27 18040.0 -56900.0 -0.91 -0.4493 -0.475 3561848 PK04_181008 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A09 compound treatment 9680.0 -75000.0 -1.24 1600.0 -73300.0 -1.17 -1.7015 -0.9996 3561850 PK04_181009 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A10 compound treatment 107440.0 22800.0 0.38 16160.0 -58700.0 -0.94 -0.3963 -0.3928 3561851 PK04_181010 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A11 compound treatment 56680.0 -28000.0 -0.46 5680.0 -69200.0 -1.1 -1.1069 -0.9254 3561853 PK04_181011 Brc1ccc(CN(C(C(=O)NCc2ccccc2)c3ccco3)C(=O)Cc4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A12 compound treatment 189480.0 105000.0 1.73 53320.0 -21600.0 -0.34 0.9801 0.5556 3561854 PK04_181012 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A13 mock treatment 196400.0 112000.0 1.84 44960.0 -29900.0 -0.48 0.9667 0.5074 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A14 mock treatment 211360.0 127000.0 2.09 47960.0 -26900.0 -0.43 1.1751 0.5504 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A15 compound treatment 44040.0 -40600.0 -0.67 3200.0 -71700.0 -1.14 -1.2824 -0.9677 3561850 PK04_181013 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A16 compound treatment 177480.0 92800.0 1.53 25040.0 -49900.0 -0.79 0.5213 0.3021 3561856 PK04_181014 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A17 compound treatment 54400.0 -30300.0 -0.5 6240.0 -68700.0 -1.09 -1.1272 -0.9369 3561858 PK04_181015 COc1ccc(CNC(=O)OCC2c3ccccc3-c4ccccc24)cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A18 compound treatment 197840.0 113000.0 1.87 23120.0 -51800.0 -0.83 0.7374 0.361 3561856 PK04_181016 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A19 compound treatment 151040.0 66400.0 1.1 29800.0 -45100.0 -0.72 0.2664 0.2033 3561859 PK04_181017 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4cc(OC)cc(OC)c4)C(=O)C13)C(=O)NCc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A20 compound treatment 114200.0 29500.0 0.49 45320.0 -29600.0 -0.47 0.0113 0.0166 3561860 PK04_181018 COc1ccc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A21 compound treatment 29560.0 -55100.0 -0.91 14200.0 -60700.0 -0.97 -1.3274 -0.9995 3561861 PK04_181019 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4ccccc4)C(=O)C13)C(=O)NCc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A22 compound treatment 52880.0 -31800.0 -0.52 45520.0 -29400.0 -0.47 -0.7022 -0.9984 3561862 PK04_181020 COc1cc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)ccc1O[SiH](C(C)C)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A23 compound treatment 12200.0 -72500.0 -1.2 25000.0 -49900.0 -0.8 -1.4083 -0.9803 3561864 PK04_181021 O=C(Cc1ccccc1)OC(C(=O)NCc2ccccc2)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 A24 compound treatment 15440.0 -69200.0 -1.14 40640.0 -34300.0 -0.55 -1.1942 -0.9429 3561865 PK04_181022 COc1cc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)ccc1O[SiH](C(C)C)C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B01 compound treatment 104480.0 19800.0 0.33 47400.0 -27500.0 -0.44 -0.0787 -0.144 3561867 PK04_181023 OC(CC=C)c1cccc(c1)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B02 compound treatment 6360.0 -78300.0 -1.29 7560.0 -67300.0 -1.07 -1.673 -0.9957 1008566 PK04_181024 Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B03 compound treatment 62480.0 -22200.0 -0.37 7440.0 -67500.0 -1.08 -1.0193 -0.8973 3561868 PK04_181025 CC(C)(C)OC(=O)OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B04 compound treatment 6000.0 -78700.0 -1.3 1880.0 -73000.0 -1.16 -1.7413 -0.9985 3561869 PK04_181026 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)[Se]c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B05 compound treatment 148120.0 63500.0 1.05 33000.0 -41900.0 -0.67 0.2684 0.216 3561870 PK04_181027 OC(CC1CO1)c2ccc(cc2)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B06 compound treatment 115120.0 30500.0 0.5 20800.0 -54100.0 -0.86 -0.2543 -0.2548 3561871 PK04_181028 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B07 compound treatment 8320.0 -76300.0 -1.26 1680.0 -73200.0 -1.17 -1.7164 -0.9993 3561872 PK04_181029 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccc(cc4)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B08 compound treatment 20760.0 -63900.0 -1.05 4240.0 -70700.0 -1.13 -1.5424 -0.9995 3561873 PK04_181030 CC(C)CC1CC(=O)C=C(Cl)N1C(=O)OC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B09 compound treatment 190880.0 106000.0 1.75 31680.0 -43200.0 -0.69 0.7526 0.3995 3561874 PK04_181031 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B10 compound treatment 184920.0 100000.0 1.65 28960.0 -45900.0 -0.73 0.6524 0.3605 3561875 PK04_181032 COC(=O)C1=C(Cl)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B11 compound treatment 10840.0 -73800.0 -1.22 3040.0 -71900.0 -1.15 -1.6717 -0.9995 3561876 PK04_181033 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B12 compound treatment 11400.0 -73300.0 -1.21 3960.0 -70900.0 -1.13 -1.6548 -0.9994 3561877 PK04_181034 COC(=O)C1=C(OC)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B13 mock treatment 187720.0 103000.0 1.7 80000.0 5100.0 0.08 1.2603 0.74 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B14 mock treatment 214320.0 130000.0 2.14 50280.0 -24600.0 -0.39 1.2358 0.568 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B15 compound treatment 130800.0 46100.0 0.76 28480.0 -46400.0 -0.74 0.0152 0.0144 3561878 PK04_181035 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B16 compound treatment 14240.0 -70400.0 -1.16 2440.0 -72500.0 -1.15 -1.6388 -1.0 3561879 PK04_181036 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)I 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B17 compound treatment 199760.0 115000.0 1.9 18160.0 -56700.0 -0.9 0.7039 0.3345 3561880 PK04_181037 OC(CC1CO1)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B18 compound treatment 177040.0 92400.0 1.52 21000.0 -53900.0 -0.86 0.4707 0.2689 3561881 PK04_181038 CC(C)(C)OC(=O)NCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B19 compound treatment 189560.0 105000.0 1.73 32440.0 -42500.0 -0.68 0.7457 0.4011 3561882 PK04_181039 CN(CC(O)CC(O)c1ccccc1)Cc2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B20 compound treatment 163280.0 78600.0 1.3 26240.0 -48700.0 -0.78 0.3691 0.2442 3561883 PK04_181040 COc1ccc(CN(C(=C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B21 compound treatment 46920.0 -37700.0 -0.62 33520.0 -41400.0 -0.66 -0.907 -0.9996 3561884 PK04_181041 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B22 compound treatment 5080.0 -79600.0 -1.31 2280.0 -72600.0 -1.16 -1.7475 -0.998 3561885 PK04_181042 COc1ccc(CNS(=O)(=O)c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-])c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B23 compound treatment 52280.0 -32400.0 -0.53 41920.0 -33000.0 -0.53 -0.7498 -1.0 3561886 PK04_181043 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccncc3)CC(O2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 B24 compound treatment 3800.0 -80900.0 -1.33 1640.0 -73300.0 -1.17 -1.7696 -0.9978 3561887 PK04_181044 Brc1ccc(cc1)S(=O)(=O)N2C[C@H]2C=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C01 compound treatment 58720.0 -25900.0 -0.43 30800.0 -44100.0 -0.7 -0.7999 -0.9718 3561889 PK04_181045 O=C(Cc1ccccc1)N2CC(=O)Oc3ccccc23 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C02 compound treatment 78560.0 -6110.0 -0.1 28000.0 -46900.0 -0.75 -0.5999 -0.7953 3561890 PK04_181046 CCCCCNC(=O)[C@H]1N(C(=O)[C@@H]2[C@H](C3OC12C=C3)C(=O)OCC)c4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C03 compound treatment 81120.0 -3550.0 -0.06 28440.0 -46500.0 -0.74 -0.5651 -0.7607 3561892 PK04_181047 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C04 compound treatment 85680.0 1010.0 0.02 24440.0 -50500.0 -0.8 -0.5569 -0.6923 2065568 PK04_181048 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C05 compound treatment 7680.0 -77000.0 -1.27 2000.0 -72900.0 -1.16 -1.7203 -0.999 3561893 PK04_181049 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)OCC=C)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C06 compound treatment 148000.0 63300.0 1.05 31040.0 -43900.0 -0.7 0.2449 0.1947 2065566 PK04_181050 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C07 compound treatment 118400.0 33700.0 0.56 16320.0 -58600.0 -0.93 -0.2665 -0.2452 3561894 PK04_181051 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)N(CC=C)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C08 compound treatment 104440.0 19800.0 0.33 18240.0 -56700.0 -0.9 -0.4078 -0.4247 2065605 PK04_181052 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2cccs2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C09 compound treatment 130840.0 46200.0 0.76 21800.0 -53100.0 -0.85 -0.0596 -0.0523 3561895 PK04_181053 O=C(Cc1ccccc1)OC(COCc2ccccc2)C(=O)NCc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C10 compound treatment 143160.0 58500.0 0.97 37040.0 -37900.0 -0.6 0.256 0.2248 2065603 PK04_181054 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3cccs3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C11 mock treatment 139920.0 55300.0 0.91 41440.0 -33500.0 -0.53 0.2678 0.2534 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C12 mock treatment 128400.0 43700.0 0.72 79800.0 4900.0 0.08 0.5656 0.779 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C13 compound treatment 137080.0 52400.0 0.87 93600.0 18700.0 0.3 0.8225 0.8988 3561896 PK04_181055 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)NCc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C14 compound treatment 139560.0 54900.0 0.91 51200.0 -23700.0 -0.38 0.3736 0.3805 2065601 PK04_181056 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3cccs3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C15 mock treatment 142080.0 57400.0 0.95 27440.0 -47500.0 -0.76 0.1352 0.1115 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C16 mock treatment 157240.0 72600.0 1.2 25040.0 -49900.0 -0.79 0.2851 0.1983 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C17 compound treatment 118960.0 34300.0 0.57 16960.0 -57900.0 -0.92 -0.2528 -0.2334 3561897 PK04_181057 OC1CCC(CC1)N2C(C(=O)NCc3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C18 compound treatment 141760.0 57100.0 0.94 17200.0 -57700.0 -0.92 0.016 0.0122 3057099 PK04_181058 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3ccco3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C19 compound treatment 98520.0 13900.0 0.23 21240.0 -53700.0 -0.86 -0.4431 -0.5005 3561892 PK04_181059 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C20 compound treatment 113760.0 29100.0 0.48 30520.0 -44400.0 -0.71 -0.1607 -0.1879 3057100 PK04_181060 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3ccco3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C21 compound treatment 103520.0 18900.0 0.31 24200.0 -50700.0 -0.81 -0.3514 -0.4058 3561898 PK04_181061 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=C[C@]42O[C@@H]5/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]4C1=O)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C22 compound treatment 110000.0 25300.0 0.42 28280.0 -46600.0 -0.74 -0.2298 -0.2695 3176076 PK04_181062 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C23 compound treatment 76280.0 -8390.0 -0.14 34680.0 -40200.0 -0.64 -0.5513 -0.8405 3561899 PK04_181063 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 C24 compound treatment 52040.0 -32600.0 -0.54 30280.0 -44600.0 -0.71 -0.8838 -0.9906 2065566 PK04_181064 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D01 compound treatment 79840.0 -4830.0 -0.08 36240.0 -38700.0 -0.62 -0.4921 -0.792 3561900 PK04_181065 COCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D02 compound treatment 63920.0 -20700.0 -0.34 32800.0 -42100.0 -0.67 -0.7167 -0.9513 3561901 PK04_181066 COc1cc(OC)c(CNS(=O)(=O)c2ccc(Br)cc2)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D03 compound treatment 102080.0 17400.0 0.29 41640.0 -33300.0 -0.53 -0.1717 -0.2847 3561902 PK04_181067 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D04 compound treatment 77560.0 -7110.0 -0.12 25520.0 -49400.0 -0.79 -0.6395 -0.8037 3561903 PK04_181068 COc1ccc(CN(C(COC(=O)c2cccc(OC)c2O)C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D05 compound treatment 32880.0 -51800.0 -0.85 10520.0 -64400.0 -1.03 -1.3301 -0.9959 3215593 PK04_181069 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)NO)cc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D06 compound treatment 94240.0 9570.0 0.16 29400.0 -45500.0 -0.73 -0.4011 -0.5404 3561904 PK04_181070 COC(=O)C1CC=C(CC1C(=O)OC)N(Cc2ccc(OC)cc2)S(=O)(=O)c3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D07 compound treatment 46520.0 -38100.0 -0.63 6320.0 -68600.0 -1.09 -1.2182 -0.9657 3561905 PK04_181071 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CN(C)Cc3ccccc3)CC(O2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D08 compound treatment 119280.0 34600.0 0.57 27360.0 -47500.0 -0.76 -0.1318 -0.1389 3561906 PK04_181072 COc1ccc(CN([C@H](COC(=O)c2ccc(cc2)[N+](=O)[O-])C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D09 compound treatment 122800.0 38100.0 0.63 35680.0 -39200.0 -0.63 0.003 0.0034 3561908 PK04_181073 OC(CSc1nc2ccccc2o1)CC(O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D10 compound treatment 117760.0 33100.0 0.55 38640.0 -36300.0 -0.58 -0.0225 -0.0282 3561909 PK04_181074 Brc1ccc(cc1)N2C(CN(C2=O)S(=O)(=O)c3ccc(Br)cc3)C=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D11 mock treatment 148480.0 63800.0 1.05 51240.0 -23700.0 -0.38 0.4781 0.4273 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D12 mock treatment 135120.0 50500.0 0.83 92640.0 17700.0 0.28 0.7888 0.8969 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D13 compound treatment 133280.0 48600.0 0.8 91640.0 16700.0 0.27 0.756 0.8941 3561910 PK04_181075 COC(=O)CCCCCCC(=O)NOCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D14 compound treatment 112920.0 28300.0 0.47 47320.0 -27600.0 -0.44 0.0189 0.0295 3561911 PK04_181076 COc1ccc(CN([C@H](CI)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D15 mock treatment 137200.0 52500.0 0.87 54440.0 -20500.0 -0.33 0.3825 0.4129 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D16 mock treatment 124960.0 40300.0 0.67 34960.0 -39900.0 -0.64 0.0201 0.0218 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D17 compound treatment 134080.0 49400.0 0.82 27280.0 -47600.0 -0.76 0.04 0.0359 3561913 PK04_181077 OC(=O)CCCCCCC(=O)NOCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D18 compound treatment 117120.0 32500.0 0.54 29680.0 -45200.0 -0.72 -0.1309 -0.1458 3561914 PK04_181078 COc1ccc(CN(C2=CCC3C(C2)C(=O)N(C)C3=O)S(=O)(=O)c4ccc(Br)cc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D19 compound treatment 132200.0 47500.0 0.78 18640.0 -56300.0 -0.9 -0.0793 -0.0666 3561915 PK04_181079 OCc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D20 compound treatment 31040.0 -53600.0 -0.89 2960.0 -71900.0 -1.15 -1.4368 -0.9918 3561916 PK04_181080 COCCCN(CC(O)CO)C[C@]1(O)CCC2[C@]1(C)CCC3[C@@]4(C)CC[C@H](O)C[C@@]54C=C[C@]23C(=C5)C(=O)c6ccc(OC)cc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D21 compound treatment 104960.0 20300.0 0.33 21560.0 -53300.0 -0.85 -0.3644 -0.3987 3561917 PK04_181081 O=Cc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D22 compound treatment 43080.0 -41600.0 -0.69 18520.0 -56400.0 -0.9 -1.1209 -0.9912 3561918 PK04_181082 COCCCN(CC(O)CO)C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D23 compound treatment 65800.0 -18900.0 -0.31 39840.0 -35100.0 -0.56 -0.6154 -0.9619 3561919 PK04_181083 OC(CN=[N+]=[N-])CC(O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 D24 compound treatment 21960.0 -62700.0 -1.04 23840.0 -51100.0 -0.81 -1.3075 -0.9929 3561920 PK04_181084 COCCCN(C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C)C(=O)O[C@H]5C[C@@H](C)CC[C@@H]5C(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E01 mock treatment 82600.0 -2070.0 -0.03 30800.0 -44100.0 -0.7 -0.5212 -0.7406 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E02 mock treatment 74920.0 -9750.0 -0.16 37040.0 -37900.0 -0.6 -0.5405 -0.8654 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E03 compound treatment 66480.0 -18200.0 -0.3 28240.0 -46700.0 -0.74 -0.7382 -0.9204 3561899 PK04_181085 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E04 compound treatment 58360.0 -26300.0 -0.43 30040.0 -44900.0 -0.72 -0.8127 -0.9714 2065568 PK04_181086 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E05 compound treatment 83360.0 -1310.0 -0.02 33200.0 -41700.0 -0.66 -0.4853 -0.7297 3561899 PK04_181087 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E06 compound treatment 89320.0 4650.0 0.08 59240.0 -15700.0 -0.25 -0.1222 -0.468 2065570 PK04_181088 O=C(NCc1ccccc1)C(COCc2ccccc2)OC(=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E07 compound treatment 127920.0 43300.0 0.71 21480.0 -53400.0 -0.85 -0.0973 -0.0875 3561899 PK04_181089 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E08 compound treatment 114760.0 30100.0 0.5 46920.0 -28000.0 -0.45 0.0358 0.0537 2065572 PK04_181090 COc1ccc(NC(=O)C(COCc2ccccc2)OC(=O)c3ccccc3)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E09 mock treatment 123480.0 38800.0 0.64 36480.0 -38400.0 -0.61 0.02 0.0225 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E10 mock treatment 140000.0 55300.0 0.91 50120.0 -24800.0 -0.4 0.3665 0.3683 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E11 compound treatment 101280.0 16600.0 0.27 44120.0 -30800.0 -0.49 -0.1531 -0.2723 3561921 PK04_181091 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E12 compound treatment 130360.0 45700.0 0.75 102680.0 27800.0 0.44 0.8464 0.9678 2065574 PK04_181092 CC(C)(C)NC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E13 compound treatment 73720.0 -10900.0 -0.18 62320.0 -12600.0 -0.2 -0.2696 -0.9987 3561922 PK04_181093 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(Cc4ccc(OC)cc4)C(=O)[C@@H]13)C(=O)NCc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E14 compound treatment 117800.0 33100.0 0.55 39440.0 -35500.0 -0.57 -0.013 -0.0165 2065576 PK04_181094 CCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E15 compound treatment 105120.0 20500.0 0.34 45120.0 -29800.0 -0.47 -0.097 -0.1665 3561841 PK04_181095 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E16 compound treatment 109480.0 24800.0 0.41 30680.0 -44200.0 -0.7 -0.2088 -0.2561 2065599 PK04_181096 CCCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E17 mock treatment 108560.0 23900.0 0.39 31160.0 -43700.0 -0.7 -0.2141 -0.2673 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E18 mock treatment 111760.0 27100.0 0.45 38000.0 -36900.0 -0.59 -0.0997 -0.1349 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E19 compound treatment 117440.0 32800.0 0.54 34440.0 -40500.0 -0.64 -0.0735 -0.0873 3561841 PK04_181097 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E20 compound treatment 114120.0 29500.0 0.49 43280.0 -31600.0 -0.5 -0.0126 -0.0181 3561923 PK04_181098 CCCNC(=O)COc1ccc(C=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E21 compound treatment 101600.0 16900.0 0.28 35400.0 -39500.0 -0.63 -0.2476 -0.3594 3561841 PK04_181099 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E22 compound treatment 88680.0 4010.0 0.07 31560.0 -43300.0 -0.69 -0.4417 -0.6364 3561924 PK04_181100 CCCNC(=O)Cc1ccc(N)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E23 compound treatment 41200.0 -43500.0 -0.72 23520.0 -51400.0 -0.82 -1.0865 -0.9978 3561841 PK04_181101 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 E24 compound treatment 61840.0 -22800.0 -0.38 21480.0 -53400.0 -0.85 -0.8686 -0.9328 3561925 PK04_181102 CCOC(=O)/C=C/c1ccccc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F01 mock treatment 118960.0 34300.0 0.57 31360.0 -43500.0 -0.69 -0.0905 -0.101 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F02 mock treatment 89160.0 4490.0 0.07 25120.0 -49800.0 -0.79 -0.5087 -0.6383 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F03 compound treatment 6520.0 -78100.0 -1.29 3040.0 -71900.0 -1.15 -1.7221 -0.9982 3561927 PK04_181103 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F04 compound treatment 80000.0 -4670.0 -0.08 34960.0 -39900.0 -0.64 -0.5047 -0.787 1366116 PK04_181104 Brc1ccc2ncnc(NCC=C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F05 compound treatment 76360.0 -8310.0 -0.14 57800.0 -17100.0 -0.27 -0.2898 -0.9495 3561928 PK04_181105 CN(CC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F06 compound treatment 7960.0 -76700.0 -1.27 4480.0 -70400.0 -1.12 -1.6891 -0.9982 1945167 PK04_181106 C/C(=C/C(=O)c1ccc(Cl)cc1)/Nc2cccc(O)c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F07 compound treatment 105880.0 21200.0 0.35 44240.0 -30700.0 -0.49 -0.098 -0.163 3561929 PK04_181107 OC(CSc1nc2ccccc2s1)CC(O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F08 compound treatment 102280.0 17600.0 0.29 31120.0 -43800.0 -0.7 -0.2879 -0.3808 1448632 PK04_181108 Nn1cnc2-c3ccccc3CC4(CCCC4)c2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F09 mock treatment 111920.0 27300.0 0.45 55000.0 -19900.0 -0.32 0.0938 0.1703 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F10 mock treatment 125520.0 40900.0 0.67 93760.0 18900.0 0.3 0.6893 0.9337 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F11 compound treatment 131160.0 46500.0 0.77 66280.0 -8620.0 -0.14 0.4455 0.5714 3561930 PK04_181109 OC(CSc1ccccn1)CC(O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F12 compound treatment 112480.0 27800.0 0.46 92840.0 17900.0 0.29 0.5268 0.974 3561931 PK04_181110 [O-][N+](=O)c1ccccc1/C=C/c2ccncc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F13 compound treatment 68120.0 -16500.0 -0.27 53600.0 -21300.0 -0.34 -0.4333 -0.9942 3561933 PK04_181111 ONC(=O)CCCCCCC(=O)NOCc1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F14 compound treatment 131200.0 46500.0 0.77 80800.0 5900.0 0.09 0.6096 0.7877 1679359 PK04_181112 OC(=O)CCCN1C(=O)CSC1=S 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F15 compound treatment 101960.0 17300.0 0.29 58240.0 -16700.0 -0.27 0.014 0.036 1020755 PK04_181113 O=C(C[n+]1ccc2ccccc2c1)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F16 compound treatment 92160.0 7490.0 0.12 49400.0 -25500.0 -0.41 -0.2 -0.4707 3561934 PK04_181114 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F17 mock treatment 116680.0 32000.0 0.53 56520.0 -18400.0 -0.29 0.1665 0.2755 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F18 mock treatment 115560.0 30900.0 0.51 50160.0 -24700.0 -0.39 0.0817 0.1267 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F19 compound treatment 89280.0 4610.0 0.08 50160.0 -24700.0 -0.39 -0.2251 -0.5603 3561936 PK04_181115 Brc1c2OCOc2ccc1C[n+]3ccc4ccccc4c3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F20 compound treatment 42920.0 -41700.0 -0.69 24480.0 -50400.0 -0.8 -1.0556 -0.9971 3561937 PK04_181116 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2/C=C/c3ccncc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F21 compound treatment 59600.0 -25100.0 -0.41 25400.0 -49500.0 -0.79 -0.8505 -0.9546 3561939 PK04_181117 CC(C)(C)[Si](C)(C)Oc1ccc2cc[n+](Cc3ccccc3Br)cc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F22 compound treatment 39840.0 -44800.0 -0.74 16720.0 -58200.0 -0.93 -1.179 -0.9937 1936946 PK04_181118 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F23 compound treatment 44600.0 -40100.0 -0.66 29720.0 -45200.0 -0.72 -0.9769 -0.9991 3561940 PK04_181119 COc1ccc(Br)c(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 F24 compound treatment 67680.0 -17000.0 -0.28 20160.0 -54700.0 -0.87 -0.8153 -0.8896 3561941 PK04_181120 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G01 compound treatment 69440.0 -15200.0 -0.25 32240.0 -42700.0 -0.68 -0.6586 -0.9084 3561841 PK04_181121 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G02 compound treatment 31560.0 -53100.0 -0.88 14120.0 -60800.0 -0.97 -1.305 -0.9988 3561943 PK04_181122 O=C1CSC(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G03 mock treatment 83600.0 -1070.0 -0.02 32280.0 -42600.0 -0.68 -0.4929 -0.7252 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G04 mock treatment 102920.0 18300.0 0.3 63960.0 -10900.0 -0.17 0.0897 0.2576 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G05 compound treatment 46800.0 -37900.0 -0.63 29480.0 -45400.0 -0.72 -0.954 -0.9973 PK04_181123 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G06 compound treatment 82920.0 -1750.0 -0.03 69880.0 -5020.0 -0.08 -0.077 -0.9051 3561944 PK04_181124 CC(C)(C)c1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G07 compound treatment 95080.0 10400.0 0.17 75360.0 456.0 0.01 0.1267 0.7364 PK04_181125 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G08 compound treatment 94400.0 9730.0 0.16 58920.0 -16000.0 -0.25 -0.0666 -0.221 3561945 PK04_181126 CCOC(=O)/C=C(\C)/c1ccccc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G09 compound treatment 93920.0 9250.0 0.15 47000.0 -27900.0 -0.44 -0.2065 -0.4392 3561841 PK04_181127 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G10 compound treatment 101120.0 16500.0 0.27 61400.0 -13500.0 -0.22 0.0398 0.1149 3561947 PK04_181128 CCOC(=O)/C=C/c1c(OC)cccc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G11 compound treatment 28040.0 -56600.0 -0.93 27920.0 -47000.0 -0.75 -1.1905 -0.994 3561899 PK04_181129 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G12 compound treatment 135480.0 50800.0 0.84 127040.0 52100.0 0.83 1.1807 1.0 3561949 PK04_181130 CCCNC(=O)Cc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G13 compound treatment 53520.0 -31100.0 -0.51 50240.0 -24700.0 -0.39 -0.6416 -0.9912 3561950 PK04_181131 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)c6cccc(Cl)c6CO)c7ccccc7 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G14 compound treatment 111400.0 26700.0 0.44 68480.0 -6420.0 -0.1 0.2396 0.529 3561952 PK04_181132 COc1cc(/C=C/CO)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G15 compound treatment 64760.0 -19900.0 -0.33 40200.0 -34700.0 -0.55 -0.6235 -0.9691 3561841 PK04_181133 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G16 compound treatment 91840.0 7170.0 0.12 67600.0 -7300.0 -0.12 0.0014 0.0083 3561954 PK04_181134 COc1ccccc1/C=C/CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G17 compound treatment 89400.0 4730.0 0.08 47840.0 -27100.0 -0.43 -0.2498 -0.5698 3561956 PK04_181135 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G18 compound treatment 85360.0 691.0 0.01 44360.0 -30500.0 -0.49 -0.3362 -0.6904 3561958 PK04_181136 O=C1CS(=O)(=O)C(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G19 mock treatment 111560.0 26900.0 0.44 84840.0 9940.0 0.16 0.4259 0.9036 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G20 mock treatment 98160.0 13500.0 0.22 80040.0 5140.0 0.08 0.2154 0.9077 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G21 compound treatment 37840.0 -46800.0 -0.77 29160.0 -45700.0 -0.73 -1.0622 -0.9996 3561959 PK04_181137 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G22 compound treatment 61000.0 -23700.0 -0.39 31000.0 -43900.0 -0.7 -0.7711 -0.9621 3561961 PK04_181138 CC(C)(C)c1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G23 compound treatment 40320.0 -44300.0 -0.73 25880.0 -49000.0 -0.78 -1.0702 -0.9995 3561959 PK04_181139 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 G24 compound treatment 30880.0 -53800.0 -0.89 19600.0 -55300.0 -0.88 -1.2511 -1.0 2093329 PK04_181140 COC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H01 compound treatment 38480.0 -46200.0 -0.76 29160.0 -45700.0 -0.73 -1.0547 -0.9997 3561962 PK04_181141 Brc1ccccc1C(=O)[n+]2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H02 compound treatment 53840.0 -30800.0 -0.51 21080.0 -53800.0 -0.86 -0.9665 -0.9689 3561963 PK04_181142 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)O)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H03 mock treatment 78400.0 -6270.0 -0.1 39760.0 -35100.0 -0.56 -0.4693 -0.8238 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H04 mock treatment 90720.0 6050.0 0.1 65720.0 -9180.0 -0.15 -0.0329 -0.1855 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H05 compound treatment 8960.0 -75700.0 -1.25 6160.0 -68700.0 -1.1 -1.6585 -0.9978 3561965 PK04_181143 COc1cc2CC[N+](=Cc2cc1O[Si](C)(C)C(C)(C)C)Cc3ccccc3Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H06 compound treatment 39120.0 -45500.0 -0.75 32280.0 -42600.0 -0.68 -1.012 -0.9987 3561966 PK04_181144 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H07 compound treatment 109440.0 24800.0 0.41 67160.0 -7740.0 -0.12 0.2019 0.4726 3561968 PK04_181145 COc1cc2CC[N+](=Cc2cc1OC)C(=O)c3ccccc3Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H08 compound treatment 17840.0 -66800.0 -1.1 24640.0 -50300.0 -0.8 -1.3465 -0.9877 3561969 PK04_181146 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3C4CC5CC(C4)CC3C5)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H09 compound treatment 7160.0 -77500.0 -1.28 4960.0 -69900.0 -1.11 -1.693 -0.9976 3561971 PK04_181147 Oc1ccc2CCN(Cc3ccccc3Br)C(C=C)c2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H10 compound treatment 34000.0 -50700.0 -0.84 28080.0 -46800.0 -0.75 -1.1191 -0.9984 3561972 PK04_181148 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(O)(C4)C3)C5)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H11 compound treatment 91800.0 7130.0 0.12 85480.0 10600.0 0.17 0.2024 0.9846 3561974 PK04_181149 Brc1c[n+](Cc2ccccc2)cc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H12 compound treatment 24800.0 -59900.0 -0.99 20440.0 -54500.0 -0.87 -1.3126 -0.9979 3561975 PK04_181150 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NCC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H13 compound treatment 83560.0 -1110.0 -0.02 81080.0 6180.0 0.1 0.0567 0.5659 3561977 PK04_181151 COc1ccc(Br)c(C[n+]2cc(Br)c3ccccc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H14 compound treatment 41080.0 -43600.0 -0.72 35720.0 -39200.0 -0.62 -0.9504 -0.9975 3561978 PK04_181152 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H15 compound treatment 98280.0 13600.0 0.22 74640.0 -264.0 0.0 0.1559 0.6938 1003512 PK04_181153 C[n+]1ccc2ccccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H16 compound treatment 52800.0 -31900.0 -0.53 48600.0 -26300.0 -0.42 -0.6684 -0.9937 3561980 PK04_181154 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H17 compound treatment 96280.0 11600.0 0.19 59400.0 -15500.0 -0.25 -0.0392 -0.1254 1032420 PK04_181155 C(c1ccccc1)[n+]2ccc3ccccc3c2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H18 compound treatment 67520.0 -17100.0 -0.28 42880.0 -32000.0 -0.51 -0.5611 -0.9613 3561982 PK04_181156 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H19 mock treatment 113600.0 28900.0 0.48 99160.0 24300.0 0.39 0.6111 0.9945 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H20 mock treatment 82600.0 -2070.0 -0.03 86320.0 11400.0 0.18 0.1045 0.5645 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H21 compound treatment 65520.0 -19100.0 -0.32 53040.0 -21900.0 -0.35 -0.4699 -0.9988 3561984 PK04_181157 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H22 compound treatment 4680.0 -80000.0 -1.32 4000.0 -70900.0 -1.13 -1.7328 -0.997 3561985 PK04_181158 O=C1C=C[C@@H]2[C@@H]3C=C[C@H]([C@@H]2[C@]41CO4)[C@@]5(CO5)C3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H23 compound treatment 3320.0 -81300.0 -1.34 2280.0 -72600.0 -1.16 -1.768 -0.9973 3561987 PK04_181159 COc1ccc(Br)c(C[n+]2ccc3c(cccc3c2)[N+](=O)[O-])c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 H24 compound treatment 33120.0 -51500.0 -0.85 24000.0 -50900.0 -0.81 -1.1754 -0.9997 3561988 PK04_181160 CC1(C)C[C@H]2C[C@H]3C(=C[C@]2(CO1)C(=O)[C@@]43CO4)Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I01 compound treatment 19320.0 -65300.0 -1.08 19520.0 -55400.0 -0.88 -1.387 -0.995 3561956 PK04_181161 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I02 compound treatment 48600.0 -36100.0 -0.6 49000.0 -25900.0 -0.41 -0.713 -0.984 3561990 PK04_181162 CCCNC(=O)Cc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I03 compound treatment 29760.0 -54900.0 -0.91 20920.0 -54000.0 -0.86 -1.2493 -0.9997 3561991 PK04_181163 OCc1c(Cl)cccc1N2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OCC=C)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I04 compound treatment 97480.0 12800.0 0.21 81400.0 6500.0 0.1 0.2227 0.946 3561993 PK04_181164 COc1ccccc1/C(=C/CO)/C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I05 mock treatment 88960.0 4290.0 0.07 62240.0 -12700.0 -0.2 -0.0926 -0.4331 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I06 mock treatment 83360.0 -1310.0 -0.02 102560.0 27700.0 0.44 0.2964 0.6716 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I07 compound treatment 40040.0 -44600.0 -0.74 36480.0 -38400.0 -0.61 -0.954 -0.9958 3561995 PK04_181165 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I08 compound treatment 94840.0 10200.0 0.17 95760.0 20900.0 0.33 0.3538 0.95 3561996 PK04_181166 COc1ccccc1/C(=C/C=O)/C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I09 compound treatment 65680.0 -19000.0 -0.31 69240.0 -5660.0 -0.09 -0.2855 -0.8752 3561998 PK04_181167 OCc1c(Cl)cccc1N2[C@@H](C(=O)NCc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)O)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I10 compound treatment 43280.0 -41400.0 -0.68 41920.0 -33000.0 -0.53 -0.8548 -0.9916 2069262 PK04_181168 COc1cc(/C=C/C=O)cc(OC)c1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I11 compound treatment 61560.0 -23100.0 -0.38 61040.0 -13900.0 -0.22 -0.426 -0.9663 3562000 PK04_181169 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4ccccc4Cl)C(=O)N(CC=C)Cc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I12 compound treatment 129680.0 45000.0 0.74 130400.0 55500.0 0.88 1.1508 0.9962 3562002 PK04_181170 CCOC(=O)/C=C/c1cccc(c1)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I13 compound treatment 105720.0 21100.0 0.35 100800.0 25900.0 0.41 0.5376 0.9963 3562003 PK04_181171 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N(Cc4ccccc4)[C@@H]5C(=O)N(Cc6ccccc6)CC=C[C@]35O[C@@H]2/C=C/CCC(=O)N1C)c7ccccc7 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I14 compound treatment 78040.0 -6630.0 -0.11 73840.0 -1060.0 -0.02 -0.0894 -0.807 3562005 PK04_181172 COc1cccc(OC)c1/C=C/CO 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I15 compound treatment 73000.0 -11700.0 -0.19 55520.0 -19400.0 -0.31 -0.3547 -0.9741 3562007 PK04_181173 CCCCNC(=O)[C@@H]1N(C2CCCCC2)C(=O)[C@H]3[C@@H]([C@H]4O[C@@]13C=C4)C(=O)OCC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I16 compound treatment 78040.0 -6630.0 -0.11 79600.0 4700.0 0.07 -0.0245 -0.1844 3562009 PK04_181174 Clc1cccc(c1)N2C(SCC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I17 compound treatment 54480.0 -30200.0 -0.5 42240.0 -32700.0 -0.52 -0.7205 -0.9998 3561995 PK04_181175 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I18 compound treatment 76760.0 -7910.0 -0.13 70240.0 -4660.0 -0.07 -0.1449 -0.9643 3065130 PK04_181176 Clc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I19 compound treatment 86920.0 2250.0 0.04 96000.0 21100.0 0.34 0.264 0.7805 3562010 PK04_181177 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I20 compound treatment 111240.0 26600.0 0.44 78360.0 3460.0 0.06 0.3491 0.7897 3562012 PK04_181178 OC/C=C/c1cccc(c1)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I21 mock treatment 71160.0 -13500.0 -0.22 89240.0 14300.0 0.23 0.0039 0.0122 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I22 mock treatment 69520.0 -15100.0 -0.25 59360.0 -15500.0 -0.25 -0.352 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I23 compound treatment 28520.0 -56100.0 -0.93 21840.0 -53100.0 -0.85 -1.2534 -0.999 3562014 PK04_181179 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N([C@@H]4C(=O)N(Cc5ccccc5)CC=C[C@]34O[C@@H]2/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 I24 compound treatment 4040.0 -80600.0 -1.33 2440.0 -72500.0 -1.15 -1.7578 -0.9975 3215604 PK04_181180 O=C/1N(C(c2ccccc2)S(=O)(=O)\C1=C/c3ccc4ccccc4c3)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J01 compound treatment 24960.0 -59700.0 -0.99 35400.0 -39500.0 -0.63 -1.1422 -0.9766 3562016 PK04_181181 COc1ccc(Br)c(C[n+]2ccccc2C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J02 compound treatment 14640.0 -70000.0 -1.16 9000.0 -65900.0 -1.05 -1.5602 -0.9989 3562017 PK04_181182 OCCCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J03 compound treatment 35640.0 -49000.0 -0.81 27440.0 -47500.0 -0.76 -1.1072 -0.9994 3562019 PK04_181183 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J04 compound treatment 21480.0 -63200.0 -1.04 21200.0 -53700.0 -0.86 -1.3428 -0.9952 3562020 PK04_181184 OCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J05 mock treatment 80960.0 -3710.0 -0.06 77080.0 2180.0 0.03 -0.0188 -0.2667 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J06 mock treatment 77240.0 -7430.0 -0.12 96560.0 21700.0 0.35 0.1574 0.4296 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J07 compound treatment 86200.0 1530.0 0.03 70440.0 -4460.0 -0.07 -0.0324 -0.4297 3562022 PK04_181185 Cc1[n+](Cc2ccccc2)ccc3ccccc13 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J08 compound treatment 6080.0 -78600.0 -1.3 7040.0 -67900.0 -1.08 -1.6822 -0.9959 3562023 PK04_181186 BrC1=C[C@@]2(Br)[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J09 compound treatment 60240.0 -24400.0 -0.4 64240.0 -10700.0 -0.17 -0.4053 -0.9262 3562025 PK04_181187 COc1ccc(Br)c(C[n+]2cccc3cc(OC)ccc23)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J10 compound treatment 5560.0 -79100.0 -1.31 7000.0 -67900.0 -1.08 -1.6887 -0.9956 3562026 PK04_181188 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@]2(Br)C(=O)[C@@]43CO4)Br 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J11 compound treatment 65520.0 -19100.0 -0.32 87280.0 12400.0 0.2 -0.084 -0.2255 3562028 PK04_181189 COc1ccc(Br)c(C[N+]2=C(C)CCC2)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J12 compound treatment 85880.0 1210.0 0.02 84920.0 10000.0 0.16 0.127 0.7895 3562029 PK04_181190 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J13 compound treatment 71360.0 -13300.0 -0.22 85440.0 10500.0 0.17 -0.0366 -0.1324 3562031 PK04_181191 COc1ccc(Br)c(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J14 compound treatment 69960.0 -14700.0 -0.24 73240.0 -1660.0 -0.03 -0.1904 -0.7797 3562032 PK04_181192 COc1ccc(CCNC(=O)[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J15 compound treatment 77120.0 -7550.0 -0.12 88440.0 13500.0 0.22 0.0644 0.2586 3562033 PK04_181193 COC(CN(Cc1cccc(OC)c1)S(=O)(=O)c2ccc(C)cc2)OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J16 compound treatment 55200.0 -29500.0 -0.49 67120.0 -7780.0 -0.12 -0.4317 -0.8599 3562034 PK04_181194 COc1ccc(CCN2C(=O)C3(CC(=O)N(Cc4ccccc4)C3c5ccccc5)c6cc(ccc26)[N+](=O)[O-])cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J17 compound treatment 76800.0 -7870.0 -0.13 105440.0 30500.0 0.49 0.2523 0.5008 3562035 PK04_181195 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J18 compound treatment 80320.0 -4350.0 -0.07 92280.0 17400.0 0.28 0.1451 0.507 3562036 PK04_181196 C[C@@]1(CCc2ccccc2)C[C@@H](C[Si](C)(C)C(c3ccccc3)c4ccccc4)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J19 compound treatment 43840.0 -40800.0 -0.67 48200.0 -26700.0 -0.43 -0.7775 -0.9754 3562038 PK04_181197 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J20 compound treatment 70960.0 -13700.0 -0.23 66000.0 -8900.0 -0.14 -0.2604 -0.9747 3562039 PK04_181198 CCCCCCC1C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J21 mock treatment 69320.0 -15300.0 -0.25 72920.0 -1980.0 -0.03 -0.2015 -0.7892 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J22 mock treatment 81720.0 -2950.0 -0.05 58840.0 -16100.0 -0.26 -0.2155 -0.8268 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J23 compound treatment 38360.0 -46300.0 -0.76 31360.0 -43500.0 -0.69 -1.0313 -0.9988 3562041 PK04_181199 COc1cc2CCN(CC=C)C(C#Cc3ccccc3)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 J24 compound treatment 37480.0 -47200.0 -0.78 22600.0 -52300.0 -0.83 -1.1403 -0.9994 3562042 PK04_181200 Cc1ccc(cc1)C2C[C@]3(CC[C@@H](CC3)C(C)(C)C)OO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K01 compound treatment 26760.0 -57900.0 -0.96 54240.0 -20700.0 -0.33 -0.9088 -0.8989 3562010 PK04_181201 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K02 compound treatment 44480.0 -40200.0 -0.66 36280.0 -38600.0 -0.62 -0.9044 -0.9993 3215602 PK04_181202 Cc1c(NC(=O)/C(=C/c2ccc3ccccc3c2)/C#N)c(=O)n(c4ccccc4)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K03 compound treatment 24040.0 -60600.0 -1.0 23880.0 -51000.0 -0.81 -1.2827 -0.9947 3562044 PK04_181203 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K04 compound treatment 38720.0 -45900.0 -0.76 34600.0 -40300.0 -0.64 -0.9906 -0.9966 3562046 PK04_181204 COc1cccc(OC)c1/C=C/C=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K05 compound treatment 5880.0 -78800.0 -1.3 10320.0 -64600.0 -1.03 -1.6475 -0.9933 2065615 PK04_181205 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K06 compound treatment 39880.0 -44800.0 -0.74 49000.0 -25900.0 -0.41 -0.8147 -0.9621 3562048 PK04_181206 Clc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K07 mock treatment 70440.0 -14200.0 -0.23 97920.0 23000.0 0.37 0.0933 0.2142 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K08 mock treatment 64280.0 -20400.0 -0.34 104920.0 30000.0 0.48 0.1003 0.1715 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K09 compound treatment 26720.0 -57900.0 -0.96 43800.0 -31100.0 -0.5 -1.027 -0.9532 3562049 PK04_181207 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K10 compound treatment 53960.0 -30700.0 -0.51 83200.0 8300.0 0.13 -0.265 -0.5057 3562051 PK04_181208 Clc1cccc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K11 compound treatment 32560.0 -52100.0 -0.86 37560.0 -37300.0 -0.6 -1.0291 -0.9838 3562052 PK04_181209 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K12 compound treatment 116120.0 31500.0 0.52 121880.0 47000.0 0.75 0.8965 0.984 3562054 PK04_181210 O=C1CSCN1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K13 compound treatment 77840.0 -6830.0 -0.11 115920.0 41000.0 0.65 0.3825 0.5767 3562052 PK04_181211 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K14 compound treatment 100400.0 15700.0 0.26 113760.0 38900.0 0.62 0.6215 0.9255 1951450 PK04_181212 Cc1c(N2C(SCC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K15 mock treatment 80880.0 -3790.0 -0.06 108960.0 34100.0 0.54 0.3396 0.6215 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K16 mock treatment 53560.0 -31100.0 -0.51 99400.0 24500.0 0.39 -0.087 -0.1349 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K17 compound treatment 5040.0 -79600.0 -1.31 7680.0 -67200.0 -1.07 -1.6871 -0.9949 3562052 PK04_181213 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K18 compound treatment 80920.0 -3750.0 -0.06 99720.0 24800.0 0.4 0.2359 0.5893 3562055 PK04_181214 CN1C(SCC1=O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K19 compound treatment 9480.0 -75200.0 -1.24 7040.0 -67900.0 -1.08 -1.6425 -0.9977 3562056 PK04_181215 COCOc1ccc2cc(Br)ccc2c1c3c(OCOC)ccc4cc(Br)ccc34 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K20 compound treatment 84200.0 -469.0 -0.01 90280.0 15400.0 0.25 0.1678 0.6844 3562057 PK04_181216 O=C1CS(=O)(=O)CN1c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K21 compound treatment 5120.0 -79500.0 -1.31 4960.0 -69900.0 -1.11 -1.7168 -0.9967 3220192 PK04_181217 CC(CO)N1C2C(=O)N(Cc3ccccc3)CC=CC42OC5C=CCOC(=O)C5C4C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K22 compound treatment 37560.0 -47100.0 -0.78 60120.0 -14800.0 -0.24 -0.7165 -0.8818 3562058 PK04_181218 CN1C(c2ccccc2)S(=O)(=O)CC1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K23 mock treatment 35640.0 -49000.0 -0.81 42400.0 -32500.0 -0.52 -0.9386 -0.9768 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 K24 mock treatment 17800.0 -66900.0 -1.1 63240.0 -11700.0 -0.19 -0.912 -0.8147 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L01 compound treatment 17800.0 -66900.0 -1.1 38000.0 -36900.0 -0.59 -1.1964 -0.9566 3562059 PK04_181219 COc1cc2CC[N+](=Cc2cc1OC)Cc3ccc(Br)cc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L02 compound treatment 30920.0 -53700.0 -0.89 35160.0 -39700.0 -0.63 -1.0753 -0.9864 3562060 PK04_181220 CCOC(=O)CCC1(C)C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L03 compound treatment 14920.0 -69700.0 -1.15 24800.0 -50100.0 -0.8 -1.3788 -0.984 3562062 PK04_181221 Cc1cc2ccccc2c[n+]1CCCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L04 compound treatment 16120.0 -68500.0 -1.13 26000.0 -48900.0 -0.78 -1.3513 -0.9834 3562063 PK04_181222 CC1(CCc2ccccc2)CC(CO)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L05 compound treatment 24520.0 -60100.0 -0.99 43800.0 -31100.0 -0.5 -1.0526 -0.9485 3562064 PK04_181223 COc1ccc(Br)c(C[n+]2cc3ccccc3cc2C)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L06 compound treatment 3520.0 -81100.0 -1.34 5760.0 -69100.0 -1.1 -1.7265 -0.9953 3562065 PK04_181224 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CC(C)(C)CO)OO2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L07 mock treatment 50760.0 -33900.0 -0.56 80520.0 5620.0 0.09 -0.3325 -0.5866 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L08 mock treatment 76520.0 -8150.0 -0.13 98440.0 23500.0 0.38 0.1701 0.4269 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L09 compound treatment 65200.0 -19500.0 -0.32 117920.0 43000.0 0.69 0.2575 0.3401 3562067 PK04_181225 CC1=[N+](C)C2C3CC=CC3C1c4ccccc24 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L10 compound treatment 37160.0 -47500.0 -0.78 52640.0 -22300.0 -0.35 -0.8055 -0.9357 3562068 PK04_181226 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L11 compound treatment 90000.0 5330.0 0.09 105440.0 30500.0 0.49 0.4064 0.8216 1006359 PK04_181227 Cc1cccc[n+]1C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L12 compound treatment 67760.0 -16900.0 -0.28 82480.0 7580.0 0.12 -0.112 -0.3682 3562070 PK04_181228 CC1(CCOCc2ccccc2)CC(C)(CCc3ccccc3)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L13 compound treatment 95640.0 11000.0 0.18 112440.0 37500.0 0.6 0.5511 0.8816 3562071 PK04_181229 C[n+]1cc2ccccc2cc1C#N 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L14 compound treatment 24520.0 -60100.0 -0.99 47800.0 -27100.0 -0.43 -1.0076 -0.9305 3562072 PK04_181230 COc1ccc(CN/2C(C3CC3)c4ccccc4C\C2=N\P(=O)(Oc5ccccc5)Oc6ccccc6)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L15 mock treatment 62200.0 -22500.0 -0.37 132120.0 57200.0 0.91 0.3826 0.3886 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L16 mock treatment 44360.0 -40300.0 -0.67 117680.0 42800.0 0.68 0.0116 0.0122 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L17 compound treatment 23840.0 -60800.0 -1.0 62600.0 -12300.0 -0.2 -0.8487 -0.8295 3562074 PK04_181231 CCCCOC1CC2[N+](=C(C)C1c3ccccc23)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L18 compound treatment 57280.0 -27400.0 -0.45 82640.0 7740.0 0.12 -0.2325 -0.4961 3562075 PK04_181232 CCCCCCC1C[C@]2(CCC[C@@H](C)C2)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L19 compound treatment 6000.0 -78700.0 -1.3 17000.0 -57900.0 -0.92 -1.5708 -0.986 3188663 PK04_181233 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L20 compound treatment 34840.0 -49800.0 -0.82 50120.0 -24800.0 -0.4 -0.8609 -0.9435 3562077 PK04_181234 CC1(CCO)CC(C)(CCc2ccccc2)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L21 compound treatment 45160.0 -39500.0 -0.65 54040.0 -20900.0 -0.33 -0.6963 -0.9511 3070955 PK04_181235 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L22 compound treatment 21440.0 -63200.0 -1.04 41440.0 -33500.0 -0.53 -1.1152 -0.9514 3562078 PK04_181236 COC(=O)CC1(C)CC(C)(CCc2ccccc2)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L23 mock treatment 41760.0 -42900.0 -0.71 52160.0 -22700.0 -0.36 -0.7572 -0.9516 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 L24 mock treatment 15560.0 -69100.0 -1.14 49160.0 -25700.0 -0.41 -1.0968 -0.9047 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M01 compound treatment 1080.0 -83600.0 -1.38 1800.0 -73100.0 -1.17 -1.7996 -0.9965 3562079 PK04_181237 CC(C)(C)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C\COC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M02 compound treatment 1520.0 -83100.0 -1.37 3080.0 -71800.0 -1.14 -1.78 -0.9959 3562081 PK04_181238 Clc1ccccc1/C=C/C=C\2/C(=O)N(CS2(=O)=O)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M03 compound treatment 18200.0 -66500.0 -1.1 29360.0 -45500.0 -0.73 -1.2891 -0.9799 3562049 PK04_181239 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M04 compound treatment 1920.0 -82700.0 -1.37 3400.0 -71500.0 -1.14 -1.7717 -0.9959 3562083 PK04_181240 CN1C(c2ccccc2)S(=O)(=O)/C(=C\C=C\c3ccccc3Cl)/C1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M05 compound treatment 3360.0 -81300.0 -1.34 11160.0 -63700.0 -1.02 -1.6675 -0.9906 3562085 PK04_181241 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M06 compound treatment 47000.0 -37700.0 -0.62 79320.0 4420.0 0.07 -0.3899 -0.6231 1053847 PK04_181242 O=C1CSC(N1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M07 compound treatment 25280.0 -59400.0 -0.98 72880.0 -2020.0 -0.03 -0.716 -0.73 3562085 PK04_181243 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M08 compound treatment 26960.0 -57700.0 -0.95 59760.0 -15100.0 -0.24 -0.8443 -0.8591 3562087 PK04_181244 COc1ccccc1/C=C/C=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M09 mock treatment 32040.0 -52600.0 -0.87 105840.0 30900.0 0.49 -0.2657 -0.2659 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M10 mock treatment 39560.0 -45100.0 -0.74 114840.0 39900.0 0.64 -0.0764 -0.078 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M11 compound treatment 17720.0 -66900.0 -1.11 41480.0 -33400.0 -0.53 -1.1582 -0.944 3562085 PK04_181245 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M12 compound treatment 90240.0 5570.0 0.09 128080.0 53200.0 0.85 0.6643 0.7793 3562088 PK04_181246 O=C1CS(=O)(=O)C(N1c2ccccc2)c3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M13 mock treatment 83440.0 -1230.0 -0.02 120640.0 45700.0 0.73 0.5011 0.6872 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M14 mock treatment 56720.0 -27900.0 -0.46 122280.0 47400.0 0.76 0.2077 0.2347 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M15 compound treatment 15800.0 -68900.0 -1.14 29760.0 -45100.0 -0.72 -1.3126 -0.9757 3562089 PK04_181247 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M16 compound treatment 5440.0 -79200.0 -1.31 32160.0 -42700.0 -0.68 -1.4065 -0.9538 2118235 PK04_181248 [O-][N+](=O)c1cccc(/C=C/C=O)c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M17 compound treatment 30520.0 -54100.0 -0.89 50280.0 -24600.0 -0.39 -0.9096 -0.9317 3562089 PK04_181249 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M18 compound treatment 10800.0 -73900.0 -1.22 21200.0 -53700.0 -0.86 -1.4675 -0.985 3562090 PK04_181250 CC(C)Cc1ccc(/C=C/C=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M19 compound treatment 15880.0 -68800.0 -1.14 29800.0 -45100.0 -0.72 -1.3113 -0.9757 3561852 PK04_181251 CCOC(=O)C1C2OC3(C=C2)C(N(C(=O)C13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M20 compound treatment 9160.0 -75500.0 -1.25 17600.0 -57300.0 -0.91 -1.5272 -0.9883 3215597 PK04_181252 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4cc(C)cc(C)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M21 compound treatment 2200.0 -82500.0 -1.36 4080.0 -70800.0 -1.13 -1.7608 -0.9957 3562092 PK04_181253 O=C1C2C3C(OC42C=CCN(Cc5ccccc5)C(=O)C4N1C6CCCCC6)C=CCOC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M22 compound treatment 25200.0 -59500.0 -0.98 44080.0 -30800.0 -0.49 -1.0415 -0.9488 3562093 PK04_181254 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M23 compound treatment 9680.0 -75000.0 -1.24 27440.0 -47500.0 -0.76 -1.4102 -0.9721 3562094 PK04_181255 O=C1C2C3C4OC2(C=C4)C(N1C5CCCCC5)C(=O)N(Cc6ccccc6)CCCCOC3=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 M24 compound treatment 11960.0 -72700.0 -1.2 40240.0 -34700.0 -0.55 -1.2394 -0.938 3562095 PK04_181256 Cc1cc(C)cc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N01 compound treatment 15720.0 -68900.0 -1.14 25720.0 -49200.0 -0.78 -1.3591 -0.9834 3188533 PK04_181257 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N02 compound treatment 14680.0 -70000.0 -1.16 65680.0 -9220.0 -0.15 -0.9209 -0.7907 3562096 PK04_181258 CC1(CCc2ccccc2)CC(C)(CC(=O)O)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N03 compound treatment 5280.0 -79400.0 -1.31 14480.0 -60400.0 -0.96 -1.6077 -0.9885 3562097 PK04_181259 C=C/C=C/[C@H]1[C@@H]2[C@H](Cc3ccccc3)OC(=O)[C@H](Cc4ccccc4)N2CC1=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N04 compound treatment 17200.0 -67500.0 -1.11 71120.0 -3780.0 -0.06 -0.8302 -0.7443 3562099 PK04_181260 CC1(CCOCc2ccccc2)CC(C)(COCc3ccccc3)OO1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N05 compound treatment 27760.0 -56900.0 -0.94 62800.0 -12100.0 -0.19 -0.8007 -0.8349 3562100 PK04_181261 Cn1c(=O)n2[C@H]3[C@@H]4[C@H](Cc5ccccc5)OC(=O)[C@H](Cc6ccccc6)N4CC3=C[C@@H](C7CC7)n2c1=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N06 compound treatment 27840.0 -56800.0 -0.94 64640.0 -10300.0 -0.16 -0.779 -0.8181 3562102 PK04_181262 C[C@@H]1CCC[C@]2(CC(C)(CCOCc3ccccc3)OO2)C1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N07 compound treatment 3640.0 -81000.0 -1.34 28960.0 -45900.0 -0.73 -1.4636 -0.9598 3562104 PK04_181263 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3[C@H]1Cc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N08 compound treatment 26400.0 -58300.0 -0.96 101240.0 26300.0 0.42 -0.3833 -0.3653 3562106 PK04_181264 CC1(C)O[C@]2(C)CC[C@@H]1OO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N09 mock treatment 26680.0 -58000.0 -0.96 119600.0 44700.0 0.71 -0.1731 -0.1451 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N10 mock treatment 41760.0 -42900.0 -0.71 117800.0 42900.0 0.68 -0.0174 -0.0177 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N11 compound treatment 28000.0 -56700.0 -0.94 83920.0 9020.0 0.14 -0.5599 -0.5915 3188666 PK04_181265 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N12 compound treatment 78840.0 -5830.0 -0.1 121040.0 46100.0 0.74 0.4519 0.6094 3562108 PK04_181266 CC[C@]1(CC[C@@H]2OO1)OC2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N13 mock treatment 79200.0 -5470.0 -0.09 114200.0 39300.0 0.63 0.379 0.599 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N14 mock treatment 60520.0 -24100.0 -0.4 118040.0 43100.0 0.69 0.2043 0.257 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N15 compound treatment 27960.0 -56700.0 -0.94 85160.0 10300.0 0.16 -0.5463 -0.5749 3188536 PK04_181267 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N16 compound treatment 20440.0 -64200.0 -1.06 125640.0 50700.0 0.81 -0.1779 -0.1334 3562110 PK04_181268 CCC[C@]1(CC[C@@H]2OO1)OC2(C)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N17 compound treatment 17480.0 -67200.0 -1.11 100560.0 25700.0 0.41 -0.4951 -0.4188 3188535 PK04_181269 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N18 compound treatment 17880.0 -66800.0 -1.1 67600.0 -7300.0 -0.12 -0.8619 -0.7774 3562112 PK04_181270 CC1(C)O[C@]2(CCc3ccccc3)CC[C@@H]1OO2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N19 compound treatment 20920.0 -63700.0 -1.05 30600.0 -44300.0 -0.71 -1.2434 -0.9812 3070940 PK04_181271 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N20 compound treatment 19360.0 -65300.0 -1.08 54760.0 -20100.0 -0.32 -0.9893 -0.8795 3562114 PK04_181272 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N21 compound treatment 8520.0 -76100.0 -1.26 16240.0 -58700.0 -0.94 -1.55 -0.9894 3188534 PK04_181273 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N22 compound treatment 16680.0 -68000.0 -1.12 59600.0 -15300.0 -0.24 -0.9661 -0.8411 3562115 PK04_181274 CC(C)(C)[C@H]1CC[C@]2(CC(C[Si](C)(C)C)OO2)CC1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N23 compound treatment 13040.0 -71600.0 -1.18 39160.0 -35700.0 -0.57 -1.2389 -0.9439 3562117 PK04_181275 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@H](C4CC4)n5n([C@@H]3[C@H]2[C@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 N24 compound treatment 15280.0 -69400.0 -1.15 56760.0 -18100.0 -0.29 -1.0144 -0.8587 1004341 PK04_181276 c1ccc2cnccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O01 compound treatment 19520.0 -65100.0 -1.08 25560.0 -49300.0 -0.79 -1.3166 -0.9882 3562118 PK04_181277 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)c4cccc(Cl)c4CO)C(=O)NCc5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O02 compound treatment 3240.0 -81400.0 -1.34 4880.0 -70000.0 -1.12 -1.7397 -0.9957 3562120 PK04_181278 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O03 compound treatment 15520.0 -69100.0 -1.14 44960.0 -29900.0 -0.48 -1.1446 -0.9251 3562122 PK04_181279 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O04 compound treatment 2360.0 -82300.0 -1.36 4040.0 -70900.0 -1.13 -1.7594 -0.9958 3562124 PK04_181280 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O05 compound treatment 21080.0 -63600.0 -1.05 68840.0 -6060.0 -0.1 -0.8106 -0.769 3562122 PK04_181281 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O06 compound treatment 2120.0 -82500.0 -1.36 6920.0 -68000.0 -1.08 -1.7297 -0.9936 3562126 PK04_181282 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4cc(C)cc(C)c4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O07 compound treatment 1960.0 -82700.0 -1.37 24800.0 -50100.0 -0.8 -1.5301 -0.9674 3562128 PK04_181283 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O08 compound treatment 2280.0 -82400.0 -1.36 7240.0 -67700.0 -1.08 -1.7243 -0.9934 3215600 PK04_181284 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O09 compound treatment 25640.0 -59000.0 -0.97 129680.0 54800.0 0.87 -0.0717 -0.0548 3562128 PK04_181285 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O10 compound treatment 26600.0 -58100.0 -0.96 119600.0 44700.0 0.71 -0.1741 -0.1458 3562130 PK04_181286 OCCSCC(O)CC(O)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O11 mock treatment 63520.0 -21100.0 -0.35 116680.0 41800.0 0.67 0.224 0.2979 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O12 mock treatment 78560.0 -6110.0 -0.1 117880.0 43000.0 0.68 0.413 0.5966 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O13 compound treatment 53520.0 -31100.0 -0.51 100160.0 25300.0 0.4 -0.0789 -0.1209 3561848 PK04_181287 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O14 compound treatment 47720.0 -36900.0 -0.61 106120.0 31200.0 0.5 -0.0795 -0.101 3562131 PK04_181288 OC(CSc1ccncc1)CC(O)c2ccccc2 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O15 compound treatment 32840.0 -51800.0 -0.86 125400.0 50500.0 0.8 -0.0359 -0.0305 3562132 PK04_181289 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O16 compound treatment 36880.0 -47800.0 -0.79 105880.0 31000.0 0.49 -0.2087 -0.2243 3562134 PK04_181290 COC(=O)CCCCCCC(=O)Nc1ccc(C=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O17 compound treatment 36680.0 -48000.0 -0.79 116200.0 41300.0 0.66 -0.0947 -0.092 3562132 PK04_181291 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O18 compound treatment 24800.0 -59900.0 -0.99 78880.0 3980.0 0.06 -0.654 -0.6604 3562135 PK04_181292 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccccn3)CC(O2)c4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O19 compound treatment 36480.0 -48200.0 -0.8 79720.0 4820.0 0.08 -0.5082 -0.6359 3561921 PK04_181293 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O20 compound treatment 37840.0 -46800.0 -0.77 93280.0 18400.0 0.29 -0.3395 -0.4107 3562136 PK04_181294 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc4ccccc4s3)CC(O2)c5ccccc5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O21 compound treatment 31320.0 -53300.0 -0.88 74880.0 -23.8 0.0 -0.623 -0.7074 3561921 PK04_181295 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O22 compound treatment 22720.0 -61900.0 -1.02 74760.0 -144.0 0.0 -0.7247 -0.7087 3562137 PK04_181296 OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O23 compound treatment 46320.0 -38300.0 -0.63 54840.0 -20100.0 -0.32 -0.6738 -0.95 3561921 PK04_181297 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 O24 compound treatment 14600.0 -70100.0 -1.16 53680.0 -21200.0 -0.34 -1.0571 -0.8772 3562138 PK04_181298 CC(C)(C)OC(=O)OC(CC=C)c1ccccc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P01 compound treatment 1120.0 -83500.0 -1.38 1400.0 -73500.0 -1.17 -1.8036 -0.9967 3562139 PK04_181299 COC(=O)C1(CCCCC1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P02 compound treatment 40360.0 -44300.0 -0.73 33600.0 -41300.0 -0.66 -0.9827 -0.9986 1015751 PK04_181300 Cc1ccncc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P03 compound treatment 23440.0 -61200.0 -1.01 32200.0 -42700.0 -0.68 -1.196 -0.9815 3562141 PK04_181301 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@H](/C=C/C3CC3)[C@@H](O)Cc4ccccc4)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P04 compound treatment 28880.0 -55800.0 -0.92 38240.0 -36700.0 -0.58 -1.0644 -0.9759 3562143 PK04_181302 COc1cc2CCN(=Cc2cc1OC)Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P05 compound treatment 15160.0 -69500.0 -1.15 31560.0 -43300.0 -0.69 -1.2998 -0.9705 3562144 PK04_181303 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=CCCC=C[C@H]4[C@@H]3[C@@H](O)Cc5ccccc5)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P06 compound treatment 19840.0 -64800.0 -1.07 103160.0 28300.0 0.45 -0.4383 -0.3775 1024512 PK04_181304 COc1cc2CCN=C(C)c2cc1OC 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P07 compound treatment 1480.0 -83200.0 -1.37 9280.0 -65600.0 -1.05 -1.7106 -0.991 3562146 PK04_181305 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3C51CCCCC5 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P08 compound treatment 15920.0 -68700.0 -1.13 97160.0 22300.0 0.35 -0.5516 -0.4639 3562148 PK04_181306 COc1cc2CC(C)N(=Cc2cc1OC)Cl 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P09 compound treatment 22880.0 -61800.0 -1.02 67360.0 -7540.0 -0.12 -0.8062 -0.785 3562149 PK04_181307 COC(=O)C1(CCCC1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P10 compound treatment 24200.0 -60500.0 -1.0 112480.0 37600.0 0.6 -0.2823 -0.2425 1003512 PK04_181308 C[n+]1ccc2ccccc2c1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P11 mock treatment 30240.0 -54400.0 -0.9 122800.0 47900.0 0.76 -0.0955 -0.081 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P12 mock treatment 57840.0 -26800.0 -0.44 119720.0 44800.0 0.71 0.1919 0.2284 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P13 compound treatment 33960.0 -50700.0 -0.84 74280.0 -624.0 -0.01 -0.5989 -0.7155 3562151 PK04_181309 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3C[C@](C)(OC)O[C@@H](Cc4ccccc4)[C@H]3/C=C/C5CC5)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P14 compound treatment 35560.0 -49100.0 -0.81 106240.0 31300.0 0.5 -0.2201 -0.2311 1009497 PK04_181310 Cc1cc[n+](C)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P15 compound treatment 23160.0 -61500.0 -1.02 69960.0 -4940.0 -0.08 -0.7737 -0.7597 3562153 PK04_181311 COC(=O)[C@@H]1N[C@H](SC1(C)C)[C@@H]2N(CC#C)[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P16 compound treatment 27480.0 -57200.0 -0.94 95400.0 20500.0 0.33 -0.4365 -0.437 1023898 PK04_181312 COc1cc2CC[N+](=Cc2cc1OC)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P17 compound treatment 9160.0 -75500.0 -1.25 37440.0 -37500.0 -0.6 -1.3036 -0.9432 3562155 PK04_181313 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC(=C[C@@H]3[C@@H](O)Cc4ccccc4)/C=C/C5CC5)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P18 compound treatment 26280.0 -58400.0 -0.96 88920.0 14000.0 0.22 -0.5236 -0.5292 1071838 PK04_181314 COc1cc2CC[N+](=C(C)c2cc1OC)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P19 compound treatment 25080.0 -59600.0 -0.98 75360.0 456.0 0.01 -0.6904 -0.7019 3562157 PK04_181315 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)C41CCCC4 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P20 compound treatment 27440.0 -57200.0 -0.94 59880.0 -15000.0 -0.24 -0.8373 -0.8592 1023900 PK04_181316 COc1cc2CC(C)[N+](=Cc2cc1OC)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P21 compound treatment 28880.0 -55800.0 -0.92 47040.0 -27900.0 -0.44 -0.9652 -0.9441 3562159 PK04_181317 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=C[C@@H](C5CC5)n6n(C4[C@@H]3[C@@H](O)Cc7ccccc7)c(=O)n(C)c6=O)C2=O 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P22 compound treatment 23640.0 -61000.0 -1.01 41800.0 -33100.0 -0.53 -1.0854 -0.9545 1107245 PK04_181318 COc1ccc(C[n+]2ccc3ccccc3c2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P23 compound treatment 1720.0 -82900.0 -1.37 10240.0 -64700.0 -1.03 -1.697 -0.9902 3562161 PK04_181319 CC(=CCc1cc(/C=C/2\OC(=O)C(=C2O)c3cc4CCC(C)(C)Oc4cc3O)ccc1O)C 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.2181 P24 compound treatment 38840.0 -45800.0 -0.76 41080.0 -33800.0 -0.54 -0.9161 -0.9862 3562163 PK04_181320 COc1ccc(C[n+]2ccc(C)cc2)cc1 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A01 mock treatment 61960.0 -25100.0 -0.41 36680.0 -50400.0 -0.8 -0.8611 -0.9527 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A02 mock treatment 56200.0 -30900.0 -0.51 53880.0 -33200.0 -0.53 -0.7345 -0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A03 mock treatment 54600.0 -32500.0 -0.54 58840.0 -28200.0 -0.45 -0.6972 -0.9962 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A04 mock treatment 56200.0 -30900.0 -0.51 123920.0 36900.0 0.59 0.0549 0.0706 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A05 mock treatment 41600.0 -45500.0 -0.75 121160.0 34100.0 0.54 -0.1466 -0.1582 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A06 mock treatment 42640.0 -44400.0 -0.73 158760.0 71700.0 1.14 0.2893 0.213 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A07 mock treatment 28840.0 -58200.0 -0.96 185080.0 98000.0 1.56 0.4248 0.2316 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A08 mock treatment 37160.0 -49900.0 -0.82 136280.0 49200.0 0.78 -0.028 -0.0246 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A09 mock treatment 33800.0 -53300.0 -0.88 137520.0 50500.0 0.8 -0.0533 -0.0447 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A10 mock treatment 47200.0 -39900.0 -0.66 164960.0 77900.0 1.24 0.4124 0.2934 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A11 mock treatment 66840.0 -20200.0 -0.33 196880.0 110000.0 1.75 1.0014 0.562 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A12 mock treatment 98240.0 11200.0 0.18 195560.0 108000.0 1.73 1.353 0.778 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A13 mock treatment 93160.0 6080.0 0.1 178160.0 91100.0 1.45 1.0976 0.7542 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A14 mock treatment 65480.0 -21600.0 -0.36 207200.0 120000.0 1.91 1.1018 0.5657 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A15 mock treatment 54240.0 -32800.0 -0.54 186400.0 99300.0 1.58 0.7362 0.4399 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A16 mock treatment 38920.0 -48200.0 -0.8 184400.0 97300.0 1.55 0.5348 0.3068 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A17 mock treatment 36680.0 -50400.0 -0.83 167280.0 80200.0 1.28 0.3157 0.207 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A18 mock treatment 37720.0 -49400.0 -0.81 202640.0 116000.0 1.84 0.7264 0.3606 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A19 mock treatment 40520.0 -46600.0 -0.77 160680.0 73600.0 1.17 0.2862 0.204 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A20 mock treatment 45920.0 -41200.0 -0.68 116720.0 29700.0 0.47 -0.1462 -0.1767 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A21 mock treatment 38920.0 -48200.0 -0.8 82400.0 -4660.0 -0.07 -0.6147 -0.7699 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A22 mock treatment 50000.0 -37100.0 -0.61 79040.0 -8020.0 -0.13 -0.5233 -0.8368 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A23 mock treatment 60680.0 -26400.0 -0.44 59080.0 -28000.0 -0.45 -0.6236 -0.9999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base A24 mock treatment 47920.0 -39200.0 -0.65 30000.0 -57100.0 -0.91 -1.1002 -0.986 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B01 mock treatment 59080.0 -28000.0 -0.46 111360.0 24300.0 0.39 -0.053 -0.088 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B02 mock treatment 57080.0 -30000.0 -0.5 129280.0 42200.0 0.67 0.1256 0.1503 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B03 mock treatment 59720.0 -27400.0 -0.45 140000.0 52900.0 0.84 0.2772 0.2897 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B04 mock treatment 46240.0 -40800.0 -0.67 144720.0 57700.0 0.92 0.1731 0.1518 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B05 mock treatment 68600.0 -18500.0 -0.31 161880.0 74800.0 1.19 0.6275 0.5098 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B06 mock treatment 54960.0 -32100.0 -0.53 170080.0 83000.0 1.32 0.5607 0.3933 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B07 mock treatment 28520.0 -58600.0 -0.97 193640.0 107000.0 1.7 0.5176 0.2648 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B08 mock treatment 62320.0 -24800.0 -0.41 211760.0 125000.0 1.99 1.1163 0.5502 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B09 mock treatment 42760.0 -44300.0 -0.73 194240.0 107000.0 1.71 0.6905 0.3716 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B10 mock treatment 45760.0 -41300.0 -0.68 203680.0 117000.0 1.86 0.832 0.4202 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B11 mock treatment 71320.0 -15800.0 -0.26 189920.0 103000.0 1.64 0.9752 0.5875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B12 mock treatment 109760.0 22700.0 0.37 206200.0 119000.0 1.9 1.6074 0.8305 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B13 mock treatment 118480.0 31400.0 0.52 197040.0 110000.0 1.75 1.6059 0.8786 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B14 mock treatment 95880.0 8800.0 0.15 196000.0 109000.0 1.74 1.3304 0.7636 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B15 mock treatment 53360.0 -33700.0 -0.56 203200.0 116000.0 1.85 0.9153 0.4735 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B16 mock treatment 43440.0 -43600.0 -0.72 205880.0 119000.0 1.89 0.8297 0.4095 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B17 mock treatment 56640.0 -30400.0 -0.5 212440.0 125000.0 2.0 1.0577 0.5133 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B18 mock treatment 28520.0 -58600.0 -0.97 173080.0 86000.0 1.37 0.2859 0.1704 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B19 mock treatment 41840.0 -45200.0 -0.75 215760.0 129000.0 2.05 0.9223 0.4225 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B20 mock treatment 44720.0 -42400.0 -0.7 165840.0 78800.0 1.26 0.3933 0.2737 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B21 mock treatment 49600.0 -37500.0 -0.62 144360.0 57300.0 0.91 0.2082 0.1888 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B22 mock treatment 45760.0 -41300.0 -0.68 120400.0 33300.0 0.53 -0.1066 -0.1233 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B23 mock treatment 39840.0 -47200.0 -0.78 115920.0 28900.0 0.46 -0.2262 -0.2499 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base B24 mock treatment 73440.0 -13600.0 -0.23 55560.0 -31500.0 -0.5 -0.5143 -0.9346 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C01 mock treatment 47200.0 -39900.0 -0.66 77040.0 -10000.0 -0.16 -0.5785 -0.8539 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C02 mock treatment 57280.0 -29800.0 -0.49 102600.0 15500.0 0.25 -0.1728 -0.3137 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C03 mock treatment 48520.0 -38600.0 -0.64 103320.0 16300.0 0.26 -0.2669 -0.3884 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C04 mock treatment 51760.0 -35300.0 -0.58 114120.0 27100.0 0.43 -0.1074 -0.1481 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C05 mock treatment 61960.0 -25100.0 -0.41 118080.0 31000.0 0.49 0.0563 0.0873 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C06 mock treatment 56120.0 -31000.0 -0.51 120680.0 33600.0 0.54 0.0175 0.0236 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C07 mock treatment 38000.0 -49100.0 -0.81 133240.0 46200.0 0.74 -0.0525 -0.048 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C08 mock treatment 45560.0 -41500.0 -0.69 156120.0 69100.0 1.1 0.2936 0.2264 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C09 mock treatment 38240.0 -48800.0 -0.81 145760.0 58700.0 0.94 0.0914 0.074 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C10 mock treatment 45680.0 -41400.0 -0.68 149440.0 62400.0 0.99 0.2197 0.1821 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C11 mock treatment 69920.0 -17200.0 -0.28 168920.0 81900.0 1.3 0.7222 0.5409 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C12 mock treatment 109160.0 22100.0 0.36 135000.0 47900.0 0.76 0.7979 0.9426 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C13 mock treatment 112320.0 25200.0 0.42 136120.0 49100.0 0.78 0.8475 0.9566 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C14 mock treatment 70840.0 -16200.0 -0.27 143240.0 56200.0 0.9 0.4435 0.4745 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C15 mock treatment 54800.0 -32300.0 -0.53 132480.0 45400.0 0.72 0.135 0.1502 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C16 mock treatment 40040.0 -47000.0 -0.78 209280.0 122000.0 1.95 0.8283 0.395 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C17 mock treatment 41520.0 -45600.0 -0.75 169200.0 82100.0 1.31 0.3939 0.2609 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C18 mock treatment 44640.0 -42400.0 -0.7 145000.0 57900.0 0.92 0.1575 0.1359 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C19 mock treatment 44640.0 -42400.0 -0.7 140320.0 53300.0 0.85 0.1048 0.0952 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C20 mock treatment 48160.0 -38900.0 -0.64 126080.0 39000.0 0.62 -0.0146 -0.0163 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C21 mock treatment 43080.0 -44000.0 -0.73 115960.0 28900.0 0.46 -0.188 -0.2185 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C22 mock treatment 35920.0 -51200.0 -0.84 111400.0 24300.0 0.39 -0.3229 -0.3475 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C23 mock treatment 33760.0 -53300.0 -0.88 86800.0 -264.0 0.0 -0.6254 -0.7105 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base C24 mock treatment 40960.0 -46100.0 -0.76 50520.0 -36500.0 -0.58 -0.9502 -0.9913 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D01 mock treatment 36600.0 -50500.0 -0.83 65880.0 -21200.0 -0.34 -0.828 -0.9209 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D02 mock treatment 43920.0 -43200.0 -0.71 89840.0 2780.0 0.04 -0.4725 -0.6619 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D03 mock treatment 51160.0 -35900.0 -0.59 77200.0 -9860.0 -0.16 -0.5305 -0.8647 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D04 mock treatment 73360.0 -13700.0 -0.23 92800.0 5740.0 0.09 -0.0955 -0.3911 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D05 mock treatment 74520.0 -12600.0 -0.21 126640.0 39600.0 0.63 0.2994 0.4509 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D06 mock treatment 92800.0 5720.0 0.09 131880.0 44800.0 0.71 0.5718 0.7936 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D07 mock treatment 55480.0 -31600.0 -0.52 130560.0 43500.0 0.69 0.1213 0.1398 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D08 mock treatment 62640.0 -24400.0 -0.4 134640.0 47600.0 0.76 0.2509 0.2921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D09 mock treatment 67840.0 -19200.0 -0.32 119200.0 32100.0 0.51 0.1376 0.2283 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D10 mock treatment 58080.0 -29000.0 -0.48 131800.0 44700.0 0.71 0.1657 0.1929 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D11 mock treatment 82080.0 -5000.0 -0.08 136680.0 49600.0 0.79 0.5008 0.6298 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D12 mock treatment 103600.0 16500.0 0.27 132440.0 45400.0 0.72 0.7042 0.9111 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D13 mock treatment 108800.0 21700.0 0.36 113160.0 26100.0 0.42 0.5476 0.9973 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D14 mock treatment 86440.0 -643.0 -0.01 140160.0 53100.0 0.85 0.5909 0.6982 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D15 mock treatment 61600.0 -25500.0 -0.42 144560.0 57500.0 0.92 0.3505 0.3477 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D16 mock treatment 58680.0 -28400.0 -0.47 132440.0 45400.0 0.72 0.1799 0.2087 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D17 mock treatment 50560.0 -36500.0 -0.6 136360.0 49300.0 0.79 0.1293 0.1305 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D18 mock treatment 49480.0 -37600.0 -0.62 135240.0 48200.0 0.77 0.104 0.1054 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D19 mock treatment 76400.0 -10700.0 -0.18 145200.0 58100.0 0.93 0.5305 0.5624 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D20 mock treatment 50800.0 -36300.0 -0.6 148120.0 61100.0 0.97 0.2646 0.2316 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D21 mock treatment 51320.0 -35800.0 -0.59 116880.0 29800.0 0.48 -0.0814 -0.1074 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D22 mock treatment 40720.0 -46400.0 -0.77 82760.0 -4300.0 -0.07 -0.5897 -0.7674 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D23 mock treatment 33520.0 -53600.0 -0.88 69480.0 -17600.0 -0.28 -0.8234 -0.8877 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base D24 mock treatment 33200.0 -53900.0 -0.89 62120.0 -24900.0 -0.4 -0.9101 -0.9341 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E01 mock treatment 31160.0 -55900.0 -0.92 106920.0 19900.0 0.32 -0.429 -0.4396 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E02 mock treatment 47480.0 -39600.0 -0.65 71200.0 -15900.0 -0.25 -0.641 -0.9146 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E03 mock treatment 52200.0 -34900.0 -0.58 88040.0 976.0 0.02 -0.3962 -0.6878 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E04 mock treatment 74840.0 -12200.0 -0.2 111240.0 24200.0 0.39 0.1296 0.2978 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E05 mock treatment 90120.0 3040.0 0.05 118720.0 31700.0 0.5 0.3922 0.7736 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E06 mock treatment 90960.0 3880.0 0.06 125320.0 38300.0 0.61 0.4764 0.7771 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E07 mock treatment 66840.0 -20200.0 -0.33 133160.0 46100.0 0.73 0.2832 0.3509 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E08 mock treatment 67840.0 -19200.0 -0.32 116240.0 29200.0 0.47 0.1042 0.185 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E09 mock treatment 78160.0 -8920.0 -0.15 121760.0 34700.0 0.55 0.2869 0.5013 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E10 mock treatment 79000.0 -8080.0 -0.13 129240.0 42200.0 0.67 0.381 0.5559 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E11 mock treatment 90520.0 3440.0 0.06 120680.0 33600.0 0.54 0.419 0.7776 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E12 mock treatment 120320.0 33200.0 0.55 125720.0 38700.0 0.62 0.8236 0.9983 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E13 mock treatment 113440.0 26400.0 0.44 142160.0 55100.0 0.88 0.9286 0.9475 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E14 mock treatment 91360.0 4280.0 0.07 131480.0 44400.0 0.71 0.5505 0.7738 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E15 mock treatment 96320.0 9240.0 0.15 126280.0 39200.0 0.63 0.5498 0.8545 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E16 mock treatment 71800.0 -15300.0 -0.25 124680.0 37600.0 0.6 0.2456 0.3775 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E17 mock treatment 91720.0 4640.0 0.08 106800.0 19700.0 0.31 0.2766 0.8542 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E18 mock treatment 74200.0 -12900.0 -0.21 126880.0 39800.0 0.63 0.2984 0.4458 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E19 mock treatment 83480.0 -3600.0 -0.06 132080.0 45000.0 0.72 0.4653 0.6463 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E20 mock treatment 82600.0 -4480.0 -0.07 106920.0 19900.0 0.32 0.1715 0.5275 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E21 mock treatment 63880.0 -23200.0 -0.38 99600.0 12500.0 0.2 -0.1295 -0.2999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E22 mock treatment 50520.0 -36600.0 -0.6 112920.0 25900.0 0.41 -0.1354 -0.1852 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E23 mock treatment 49920.0 -37200.0 -0.61 55640.0 -31400.0 -0.5 -0.7879 -0.9949 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base E24 mock treatment 19280.0 -67800.0 -1.12 52040.0 -35000.0 -0.56 -1.1861 -0.9484 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F01 mock treatment 28480.0 -58600.0 -0.97 106680.0 19600.0 0.31 -0.463 -0.4554 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F02 mock treatment 47400.0 -39700.0 -0.66 108400.0 21300.0 0.34 -0.2227 -0.3018 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F03 mock treatment 50480.0 -36600.0 -0.6 83280.0 -3780.0 -0.06 -0.4699 -0.7738 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F04 mock treatment 88320.0 1240.0 0.02 105360.0 18300.0 0.29 0.2206 0.7548 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F05 mock treatment 85960.0 -1120.0 -0.02 105800.0 18700.0 0.3 0.1981 0.6619 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F06 mock treatment 103920.0 16800.0 0.28 117040.0 30000.0 0.48 0.5344 0.9668 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F07 mock treatment 95480.0 8400.0 0.14 116360.0 29300.0 0.47 0.4282 0.8791 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F08 mock treatment 97880.0 10800.0 0.18 116480.0 29400.0 0.47 0.4576 0.9122 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F09 mock treatment 88280.0 1200.0 0.02 119160.0 32100.0 0.51 0.3757 0.7339 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F10 mock treatment 95160.0 8080.0 0.13 118680.0 31600.0 0.5 0.4506 0.8645 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F11 mock treatment 107200.0 20100.0 0.33 132720.0 45700.0 0.73 0.7494 0.9369 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F12 mock treatment 130000.0 42900.0 0.71 122680.0 35600.0 0.57 0.9023 0.994 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F13 mock treatment 114640.0 27600.0 0.45 123400.0 36300.0 0.58 0.7312 0.9929 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F14 mock treatment 106600.0 19500.0 0.32 128080.0 41000.0 0.65 0.6901 0.9468 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F15 mock treatment 84920.0 -2160.0 -0.04 122600.0 35500.0 0.57 0.3753 0.6612 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F16 mock treatment 72680.0 -14400.0 -0.24 121880.0 34800.0 0.55 0.2243 0.3715 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F17 mock treatment 81200.0 -5880.0 -0.1 125920.0 38900.0 0.62 0.3692 0.589 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F18 mock treatment 84200.0 -2880.0 -0.05 118480.0 31400.0 0.5 0.3204 0.637 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F19 mock treatment 89680.0 2600.0 0.04 115040.0 28000.0 0.45 0.3456 0.7715 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F20 mock treatment 84280.0 -2800.0 -0.05 112720.0 25700.0 0.41 0.2564 0.6231 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F21 mock treatment 70600.0 -16500.0 -0.27 112320.0 25300.0 0.4 0.0922 0.1899 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F22 mock treatment 64160.0 -22900.0 -0.38 77960.0 -9100.0 -0.15 -0.3702 -0.9134 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F23 mock treatment 52160.0 -34900.0 -0.58 58280.0 -28800.0 -0.46 -0.732 -0.9936 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base F24 mock treatment 29960.0 -57100.0 -0.94 70280.0 -16800.0 -0.27 -0.8559 -0.8733 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G01 mock treatment 41880.0 -45200.0 -0.75 68280.0 -18800.0 -0.3 -0.7393 -0.9196 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G02 mock treatment 31640.0 -55400.0 -0.92 67160.0 -19900.0 -0.32 -0.8715 -0.8997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G03 mock treatment 61760.0 -25300.0 -0.42 88800.0 1740.0 0.03 -0.276 -0.6589 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G04 mock treatment 77080.0 -10000.0 -0.17 105280.0 18200.0 0.29 0.0885 0.2651 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G05 mock treatment 89200.0 2120.0 0.03 113800.0 26700.0 0.43 0.326 0.7625 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G06 mock treatment 97760.0 10700.0 0.18 124120.0 37100.0 0.59 0.5423 0.8798 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G07 mock treatment 91680.0 4600.0 0.08 111800.0 24700.0 0.39 0.3324 0.828 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G08 mock treatment 89600.0 2520.0 0.04 106800.0 19700.0 0.31 0.2518 0.7936 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G09 mock treatment 98920.0 11800.0 0.2 111520.0 24500.0 0.39 0.4138 0.949 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G10 mock treatment 100920.0 13800.0 0.23 121400.0 34300.0 0.55 0.5485 0.9249 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G11 mock treatment 107160.0 20100.0 0.33 123600.0 36500.0 0.58 0.6461 0.9643 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G12 mock treatment 118200.0 31100.0 0.51 116000.0 28900.0 0.46 0.6893 0.9986 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G13 mock treatment 119040.0 32000.0 0.53 123640.0 36600.0 0.58 0.7852 0.9988 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G14 mock treatment 107080.0 20000.0 0.33 112240.0 25200.0 0.4 0.5172 0.9953 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G15 mock treatment 91600.0 4520.0 0.07 110280.0 23200.0 0.37 0.3144 0.8329 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G16 mock treatment 106400.0 19300.0 0.32 114000.0 26900.0 0.43 0.5291 0.9893 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G17 mock treatment 87360.0 277.0 0.0 106880.0 19800.0 0.32 0.2266 0.7173 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G18 mock treatment 92320.0 5240.0 0.09 116480.0 29400.0 0.47 0.3927 0.8236 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G19 mock treatment 93920.0 6840.0 0.11 113360.0 26300.0 0.42 0.3762 0.8666 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G20 mock treatment 87520.0 437.0 0.01 99640.0 12600.0 0.2 0.1468 0.7321 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G21 mock treatment 93120.0 6040.0 0.1 100760.0 13700.0 0.22 0.2248 0.9369 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G22 mock treatment 67480.0 -19600.0 -0.32 89680.0 2620.0 0.04 -0.1993 -0.6109 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G23 mock treatment 50600.0 -36500.0 -0.6 64800.0 -22300.0 -0.35 -0.6768 -0.9682 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base G24 mock treatment 42160.0 -44900.0 -0.74 40360.0 -46700.0 -0.74 -1.0507 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H01 mock treatment 46480.0 -40600.0 -0.67 35680.0 -51400.0 -0.82 -1.053 -0.995 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H02 mock treatment 53000.0 -34100.0 -0.56 83880.0 -3180.0 -0.05 -0.4337 -0.7678 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H03 mock treatment 82920.0 -4160.0 -0.07 80160.0 -6900.0 -0.11 -0.1264 -0.9743 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H04 mock treatment 86080.0 -1000.0 -0.02 91600.0 4540.0 0.07 0.0394 0.5314 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H05 mock treatment 120480.0 33400.0 0.55 103240.0 16200.0 0.26 0.5721 0.9401 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H06 mock treatment 108840.0 21800.0 0.36 112960.0 25900.0 0.41 0.5458 0.9976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H07 mock treatment 117440.0 30400.0 0.5 106400.0 19300.0 0.31 0.5723 0.9727 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H08 mock treatment 94560.0 7480.0 0.12 103680.0 16600.0 0.26 0.2745 0.9396 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H09 mock treatment 114800.0 27700.0 0.46 116880.0 29800.0 0.48 0.6596 0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H10 mock treatment 109760.0 22700.0 0.37 118800.0 31700.0 0.51 0.6224 0.989 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H11 mock treatment 114640.0 27600.0 0.45 126880.0 39800.0 0.63 0.7704 0.9867 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H12 mock treatment 130000.0 42900.0 0.71 129800.0 42700.0 0.68 0.9826 0.9998 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H13 mock treatment 123120.0 36000.0 0.59 122720.0 35700.0 0.57 0.8225 0.9997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H14 mock treatment 122280.0 35200.0 0.58 121440.0 34400.0 0.55 0.7983 0.9996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H15 mock treatment 103600.0 16500.0 0.27 102400.0 15300.0 0.24 0.3656 0.9985 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H16 mock treatment 110240.0 23200.0 0.38 107760.0 20700.0 0.33 0.5035 0.9973 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H17 mock treatment 110760.0 23700.0 0.39 99480.0 12400.0 0.2 0.4163 0.9503 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H18 mock treatment 102040.0 15000.0 0.25 111560.0 24500.0 0.39 0.4507 0.9756 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H19 mock treatment 111880.0 24800.0 0.41 107680.0 20600.0 0.33 0.5218 0.9941 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H20 mock treatment 95800.0 8720.0 0.14 97880.0 10800.0 0.17 0.2236 0.996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H21 mock treatment 84520.0 -2560.0 -0.04 82040.0 -5020.0 -0.08 -0.0865 -0.9555 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H22 mock treatment 91960.0 4880.0 0.08 90080.0 3020.0 0.05 0.0909 0.9696 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H23 mock treatment 55920.0 -31200.0 -0.51 83200.0 -3860.0 -0.06 -0.4073 -0.7861 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base H24 mock treatment 40280.0 -46800.0 -0.77 35640.0 -51400.0 -0.82 -1.1259 -0.9996 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I01 mock treatment 51800.0 -35300.0 -0.58 44720.0 -42300.0 -0.67 -0.8891 -0.9973 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I02 mock treatment 68440.0 -18600.0 -0.31 70600.0 -16500.0 -0.26 -0.4032 -0.9969 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I03 mock treatment 88040.0 957.0 0.02 76560.0 -10500.0 -0.17 -0.1072 -0.6375 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I04 mock treatment 92640.0 5560.0 0.09 102720.0 15700.0 0.25 0.2413 0.9077 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I05 mock treatment 106640.0 19600.0 0.32 107440.0 20400.0 0.32 0.4579 1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I06 mock treatment 113400.0 26300.0 0.43 102280.0 15200.0 0.24 0.4787 0.9621 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I07 mock treatment 120040.0 33000.0 0.54 127480.0 40400.0 0.64 0.8402 0.9965 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I08 mock treatment 111800.0 24700.0 0.41 99080.0 12000.0 0.19 0.4239 0.9406 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I09 mock treatment 106520.0 19400.0 0.32 96360.0 9300.0 0.15 0.3316 0.9384 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I10 mock treatment 122440.0 35400.0 0.58 105400.0 18300.0 0.29 0.6194 0.9489 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I11 mock treatment 129480.0 42400.0 0.7 111880.0 24800.0 0.4 0.7746 0.9635 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I12 mock treatment 135080.0 48000.0 0.79 136560.0 49500.0 0.79 1.1181 1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I13 mock treatment 130200.0 43100.0 0.71 122080.0 35000.0 0.56 0.8979 0.9928 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I14 mock treatment 119880.0 32800.0 0.54 108360.0 21300.0 0.34 0.6228 0.9747 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I15 mock treatment 118760.0 31700.0 0.52 103160.0 16100.0 0.26 0.5512 0.9463 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I16 mock treatment 121880.0 34800.0 0.57 92680.0 5620.0 0.09 0.4695 0.8076 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I17 mock treatment 114360.0 27300.0 0.45 89080.0 2020.0 0.03 0.3411 0.7556 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I18 mock treatment 108440.0 21400.0 0.35 98240.0 11200.0 0.18 0.3752 0.95 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I19 mock treatment 131720.0 44600.0 0.74 123520.0 36500.0 0.58 0.9319 0.9931 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I20 mock treatment 89400.0 2320.0 0.04 91080.0 4020.0 0.06 0.0723 0.9697 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I21 mock treatment 88440.0 1360.0 0.02 72480.0 -14600.0 -0.23 -0.1485 -0.636 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I22 mock treatment 82040.0 -5040.0 -0.08 85800.0 -1260.0 -0.02 -0.0731 -0.8536 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I23 mock treatment 81200.0 -5880.0 -0.1 62640.0 -24400.0 -0.39 -0.3439 -0.8572 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base I24 mock treatment 52560.0 -34500.0 -0.57 34400.0 -52700.0 -0.84 -0.9965 -0.9822 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J01 mock treatment 77440.0 -9640.0 -0.16 38880.0 -48200.0 -0.77 -0.6556 -0.8359 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J02 mock treatment 59080.0 -28000.0 -0.46 86880.0 -184.0 0.0 -0.3289 -0.7116 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J03 mock treatment 71560.0 -15500.0 -0.26 72960.0 -14100.0 -0.22 -0.3401 -0.9979 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J04 mock treatment 98840.0 11800.0 0.19 83800.0 -3260.0 -0.05 0.1004 0.4999 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J05 mock treatment 103360.0 16300.0 0.27 88880.0 1820.0 0.03 0.2105 0.7788 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J06 mock treatment 102680.0 15600.0 0.26 91200.0 4140.0 0.07 0.2287 0.8604 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J07 mock treatment 131280.0 44200.0 0.73 89720.0 2660.0 0.04 0.5458 0.7469 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J08 mock treatment 115760.0 28700.0 0.47 90920.0 3860.0 0.06 0.3782 0.7923 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J09 mock treatment 116280.0 29200.0 0.48 95000.0 7940.0 0.13 0.4302 0.8634 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J10 mock treatment 114040.0 27000.0 0.44 94440.0 7380.0 0.12 0.3978 0.8643 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J11 mock treatment 126480.0 39400.0 0.65 122520.0 35500.0 0.57 0.8595 0.9976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J12 mock treatment 123560.0 36500.0 0.6 122400.0 35300.0 0.56 0.824 0.9994 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J13 mock treatment 126600.0 39500.0 0.65 116480.0 29400.0 0.47 0.7928 0.9869 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J14 mock treatment 135560.0 48500.0 0.8 106000.0 18900.0 0.3 0.7793 0.9111 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J15 mock treatment 112520.0 25400.0 0.42 94640.0 7580.0 0.12 0.3823 0.875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J16 mock treatment 128720.0 41600.0 0.69 78280.0 -8780.0 -0.14 0.387 0.5517 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J17 mock treatment 130360.0 43300.0 0.71 89440.0 2380.0 0.04 0.5319 0.7435 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J18 mock treatment 122120.0 35000.0 0.58 89000.0 1940.0 0.03 0.4308 0.7438 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J19 mock treatment 105680.0 18600.0 0.31 85720.0 -1340.0 -0.02 0.2019 0.6562 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J20 mock treatment 114080.0 27000.0 0.45 90440.0 3380.0 0.05 0.3532 0.7868 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J21 mock treatment 99440.0 12400.0 0.2 90520.0 3460.0 0.06 0.1832 0.867 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J22 mock treatment 80960.0 -6120.0 -0.1 56360.0 -30700.0 -0.49 -0.4175 -0.8355 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J23 mock treatment 61800.0 -25300.0 -0.42 56200.0 -30900.0 -0.49 -0.643 -0.9967 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base J24 mock treatment 60880.0 -26200.0 -0.43 43560.0 -43500.0 -0.69 -0.7961 -0.9742 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K01 mock treatment 124720.0 37600.0 0.62 29400.0 -57700.0 -0.92 -0.2106 -0.1898 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K02 mock treatment 62240.0 -24800.0 -0.41 42760.0 -44300.0 -0.71 -0.7893 -0.9666 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K03 mock treatment 94560.0 7480.0 0.12 54720.0 -32300.0 -0.52 -0.2772 -0.523 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K04 mock treatment 87280.0 197.0 0.0 78600.0 -8460.0 -0.13 -0.0931 -0.6898 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K05 mock treatment 100000.0 12900.0 0.21 81480.0 -5580.0 -0.09 0.0878 0.3802 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K06 mock treatment 121720.0 34600.0 0.57 104000.0 16900.0 0.27 0.5952 0.9413 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K07 mock treatment 131600.0 44500.0 0.73 85800.0 -1260.0 -0.02 0.5054 0.6875 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K08 mock treatment 122040.0 35000.0 0.58 81360.0 -5700.0 -0.09 0.3437 0.5884 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K09 mock treatment 120680.0 33600.0 0.55 79360.0 -7700.0 -0.12 0.3053 0.5375 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K10 mock treatment 122040.0 35000.0 0.58 87760.0 696.0 0.01 0.4159 0.7206 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K11 mock treatment 121240.0 34200.0 0.56 100960.0 13900.0 0.22 0.5553 0.9167 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K12 mock treatment 132280.0 45200.0 0.75 113960.0 26900.0 0.43 0.8307 0.9654 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K13 mock treatment 130560.0 43500.0 0.72 112640.0 25600.0 0.41 0.7957 0.9641 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K14 mock treatment 120600.0 33500.0 0.55 92840.0 5780.0 0.09 0.4563 0.8136 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K15 mock treatment 115760.0 28700.0 0.47 89200.0 2140.0 0.03 0.3588 0.756 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K16 mock treatment 114320.0 27200.0 0.45 68760.0 -18300.0 -0.29 0.1116 0.2083 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K17 mock treatment 122040.0 35000.0 0.58 80360.0 -6700.0 -0.11 0.3325 0.5665 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K18 mock treatment 114560.0 27500.0 0.45 85200.0 -1860.0 -0.03 0.2997 0.6594 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K19 mock treatment 118680.0 31600.0 0.52 100560.0 13500.0 0.22 0.5209 0.9233 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K20 mock treatment 80840.0 -6240.0 -0.1 82160.0 -4900.0 -0.08 -0.1281 -0.9907 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K21 mock treatment 89160.0 2080.0 0.03 69040.0 -18000.0 -0.29 -0.1789 -0.6183 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K22 mock treatment 82800.0 -4280.0 -0.07 44400.0 -42700.0 -0.68 -0.5308 -0.7764 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K23 mock treatment 76320.0 -10800.0 -0.18 62320.0 -24700.0 -0.39 -0.4045 -0.9351 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base K24 mock treatment 113040.0 26000.0 0.43 32760.0 -54300.0 -0.87 -0.309 -0.32 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L01 mock treatment 69120.0 -18000.0 -0.3 27240.0 -59800.0 -0.95 -0.8839 -0.8852 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L02 mock treatment 73840.0 -13200.0 -0.22 47160.0 -39900.0 -0.64 -0.6043 -0.8986 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L03 mock treatment 73680.0 -13400.0 -0.22 54080.0 -33000.0 -0.53 -0.5282 -0.926 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L04 mock treatment 80840.0 -6240.0 -0.1 68680.0 -18400.0 -0.29 -0.2801 -0.9017 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L05 mock treatment 99040.0 12000.0 0.2 77040.0 -10000.0 -0.16 0.0266 0.1047 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L06 mock treatment 110480.0 23400.0 0.39 80600.0 -6460.0 -0.1 0.2003 0.501 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L07 mock treatment 119320.0 32200.0 0.53 57440.0 -29600.0 -0.47 0.0424 0.0596 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L08 mock treatment 118280.0 31200.0 0.51 82480.0 -4580.0 -0.07 0.3125 0.6008 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L09 mock treatment 118800.0 31700.0 0.52 78440.0 -8620.0 -0.14 0.273 0.5044 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L10 mock treatment 130680.0 43600.0 0.72 84800.0 -2260.0 -0.04 0.4834 0.6708 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L11 mock treatment 124640.0 37600.0 0.62 96840.0 9780.0 0.16 0.5486 0.8581 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L12 mock treatment 119360.0 32300.0 0.53 113000.0 25900.0 0.41 0.6691 0.9921 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L13 mock treatment 122920.0 35800.0 0.59 102200.0 15100.0 0.24 0.5889 0.9218 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L14 mock treatment 122440.0 35400.0 0.58 100160.0 13100.0 0.21 0.5603 0.9039 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L15 mock treatment 124720.0 37600.0 0.62 74800.0 -12300.0 -0.2 0.3011 0.4623 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L16 mock treatment 120120.0 33000.0 0.55 59120.0 -27900.0 -0.45 0.0707 0.1004 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L17 mock treatment 121200.0 34100.0 0.56 58600.0 -28500.0 -0.45 0.0774 0.1071 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L18 mock treatment 107000.0 19900.0 0.33 67480.0 -19600.0 -0.31 0.0118 0.026 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L19 mock treatment 114200.0 27100.0 0.45 77360.0 -9700.0 -0.15 0.2072 0.4374 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L20 mock treatment 111240.0 24200.0 0.4 64360.0 -22700.0 -0.36 0.0261 0.0485 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L21 mock treatment 92640.0 5560.0 0.09 49680.0 -37400.0 -0.6 -0.3565 -0.5913 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L22 mock treatment 81080.0 -6000.0 -0.1 43080.0 -44000.0 -0.7 -0.5658 -0.7991 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L23 mock treatment 64040.0 -23000.0 -0.38 38200.0 -48900.0 -0.78 -0.8197 -0.9457 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base L24 mock treatment 72080.0 -15000.0 -0.25 25640.0 -61400.0 -0.98 -0.8674 -0.8589 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M01 mock treatment 92520.0 5440.0 0.09 38640.0 -48400.0 -0.77 -0.4823 -0.6207 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M02 mock treatment 86400.0 -683.0 -0.01 45360.0 -41700.0 -0.66 -0.478 -0.719 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M03 mock treatment 66160.0 -20900.0 -0.35 43360.0 -43700.0 -0.7 -0.7368 -0.9476 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M04 mock treatment 84360.0 -2720.0 -0.04 56480.0 -30600.0 -0.49 -0.3765 -0.769 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M05 mock treatment 86680.0 -403.0 -0.01 48720.0 -38300.0 -0.61 -0.4368 -0.7148 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M06 mock treatment 111520.0 24400.0 0.4 58840.0 -28200.0 -0.45 -0.0329 -0.0544 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M07 mock treatment 112160.0 25100.0 0.41 44920.0 -42100.0 -0.67 -0.1823 -0.231 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M08 mock treatment 113640.0 26600.0 0.44 42520.0 -44500.0 -0.71 -0.192 -0.2301 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M09 mock treatment 112280.0 25200.0 0.42 53440.0 -33600.0 -0.54 -0.0848 -0.1251 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M10 mock treatment 121440.0 34400.0 0.57 57960.0 -29100.0 -0.46 0.073 0.0997 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M11 mock treatment 183760.0 96700.0 1.6 72920.0 -14100.0 -0.23 0.969 0.6013 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M12 mock treatment 127640.0 40600.0 0.67 94760.0 7700.0 0.12 0.5601 0.823 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M13 mock treatment 160280.0 73200.0 1.21 123880.0 36800.0 0.59 1.2693 0.945 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M14 mock treatment 140360.0 53300.0 0.88 72640.0 -14400.0 -0.23 0.4593 0.5053 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M15 mock treatment 126200.0 39100.0 0.65 52040.0 -35000.0 -0.56 0.0619 0.0725 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M16 mock treatment 128800.0 41700.0 0.69 57720.0 -29300.0 -0.47 0.1562 0.1877 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M17 mock treatment 122120.0 35000.0 0.58 64240.0 -22800.0 -0.36 0.1517 0.2221 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M18 mock treatment 113040.0 26000.0 0.43 65680.0 -21400.0 -0.34 0.062 0.1132 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M19 mock treatment 129640.0 42600.0 0.7 68760.0 -18300.0 -0.29 0.2905 0.3818 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M20 mock treatment 105400.0 18300.0 0.3 66800.0 -20300.0 -0.32 -0.0146 -0.0329 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M21 mock treatment 107400.0 20300.0 0.34 50360.0 -36700.0 -0.59 -0.1765 -0.2618 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M22 mock treatment 84200.0 -2880.0 -0.05 44280.0 -42800.0 -0.68 -0.5158 -0.7546 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M23 mock treatment 87640.0 557.0 0.01 43800.0 -43300.0 -0.69 -0.4811 -0.6976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base M24 mock treatment 61680.0 -25400.0 -0.42 28080.0 -59000.0 -0.94 -0.9613 -0.9338 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N01 mock treatment 78200.0 -8880.0 -0.15 37800.0 -49300.0 -0.79 -0.6589 -0.8249 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N02 mock treatment 101600.0 14500.0 0.24 34360.0 -52700.0 -0.84 -0.4245 -0.486 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N03 mock treatment 99680.0 12600.0 0.21 32520.0 -54500.0 -0.87 -0.4677 -0.5232 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N04 mock treatment 96480.0 9400.0 0.16 42360.0 -44700.0 -0.71 -0.3941 -0.5405 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N05 mock treatment 85920.0 -1160.0 -0.02 42480.0 -44600.0 -0.71 -0.516 -0.7259 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N06 mock treatment 109160.0 22100.0 0.36 56880.0 -30200.0 -0.48 -0.0825 -0.1367 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N07 mock treatment 109280.0 22200.0 0.37 36000.0 -51100.0 -0.81 -0.3164 -0.3545 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N08 mock treatment 114920.0 27800.0 0.46 47960.0 -39100.0 -0.62 -0.1158 -0.1495 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N09 mock treatment 117840.0 30800.0 0.51 37720.0 -49300.0 -0.79 -0.1971 -0.2106 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N10 mock treatment 115840.0 28800.0 0.47 71680.0 -15400.0 -0.25 0.1623 0.3037 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N11 mock treatment 126160.0 39100.0 0.65 74080.0 -13000.0 -0.21 0.3098 0.4573 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N12 mock treatment 115560.0 28500.0 0.47 88440.0 1380.0 0.02 0.3479 0.7393 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N13 mock treatment 120840.0 33800.0 0.56 93520.0 6460.0 0.1 0.4668 0.8238 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N14 mock treatment 129320.0 42200.0 0.7 90200.0 3140.0 0.05 0.5284 0.7559 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N15 mock treatment 113120.0 26000.0 0.43 60200.0 -26900.0 -0.43 0.0012 0.0019 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N16 mock treatment 124040.0 37000.0 0.61 45840.0 -41200.0 -0.66 -0.0332 -0.0371 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N17 mock treatment 115560.0 28500.0 0.47 39120.0 -47900.0 -0.76 -0.2079 -0.2318 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N18 mock treatment 116920.0 29800.0 0.49 36200.0 -50900.0 -0.81 -0.225 -0.2372 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N19 mock treatment 117880.0 30800.0 0.51 47120.0 -39900.0 -0.64 -0.0907 -0.1113 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N20 mock treatment 92560.0 5480.0 0.09 44200.0 -42900.0 -0.68 -0.4192 -0.6082 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N21 mock treatment 98440.0 11400.0 0.19 43040.0 -44000.0 -0.7 -0.3636 -0.5006 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N22 mock treatment 91280.0 4200.0 0.07 43120.0 -43900.0 -0.7 -0.4463 -0.6341 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N23 mock treatment 78280.0 -8800.0 -0.15 35560.0 -51500.0 -0.82 -0.6832 -0.8195 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base N24 mock treatment 73600.0 -13500.0 -0.22 32800.0 -54300.0 -0.86 -0.7689 -0.861 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O01 mock treatment 67160.0 -19900.0 -0.33 36680.0 -50400.0 -0.8 -0.8004 -0.9223 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O02 mock treatment 86280.0 -803.0 -0.01 41520.0 -45500.0 -0.73 -0.5227 -0.7199 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O03 mock treatment 92080.0 5000.0 0.08 29680.0 -57400.0 -0.91 -0.5884 -0.6407 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O04 mock treatment 107360.0 20300.0 0.33 45680.0 -41400.0 -0.66 -0.2297 -0.3106 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O05 mock treatment 117400.0 30300.0 0.5 39720.0 -47300.0 -0.75 -0.1797 -0.1985 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O06 mock treatment 131040.0 44000.0 0.73 30400.0 -56700.0 -0.9 -0.1255 -0.1084 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O07 mock treatment 113720.0 26600.0 0.44 36640.0 -50400.0 -0.8 -0.2574 -0.2809 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O08 mock treatment 121880.0 34800.0 0.57 27560.0 -59500.0 -0.95 -0.2645 -0.2385 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O09 mock treatment 118640.0 31600.0 0.52 27360.0 -59700.0 -0.95 -0.3045 -0.2807 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O10 mock treatment 118640.0 31600.0 0.52 42960.0 -44100.0 -0.7 -0.1287 -0.1471 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O11 mock treatment 118120.0 31000.0 0.51 45640.0 -41400.0 -0.66 -0.1046 -0.1251 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O12 mock treatment 118520.0 31400.0 0.52 79320.0 -7740.0 -0.12 0.2797 0.5243 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O13 mock treatment 107000.0 19900.0 0.33 70120.0 -16900.0 -0.27 0.0415 0.0976 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O14 mock treatment 126200.0 39100.0 0.65 70000.0 -17100.0 -0.27 0.2643 0.3772 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O15 mock treatment 121920.0 34800.0 0.58 50800.0 -36300.0 -0.58 -0.0021 -0.0025 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O16 mock treatment 114600.0 27500.0 0.45 46720.0 -40300.0 -0.64 -0.1335 -0.1696 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O17 mock treatment 119120.0 32000.0 0.53 50240.0 -36800.0 -0.59 -0.0411 -0.052 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O18 mock treatment 116720.0 29600.0 0.49 28360.0 -58700.0 -0.94 -0.3157 -0.299 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O19 mock treatment 123160.0 36100.0 0.6 46920.0 -40100.0 -0.64 -0.0313 -0.0358 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O20 mock treatment 93440.0 6360.0 0.1 46640.0 -40400.0 -0.64 -0.3814 -0.5842 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O21 mock treatment 150040.0 63000.0 1.04 35560.0 -51500.0 -0.82 0.1544 0.1166 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O22 mock treatment 101040.0 14000.0 0.23 35120.0 -51900.0 -0.83 -0.4225 -0.4916 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O23 mock treatment 84160.0 -2920.0 -0.05 42840.0 -44200.0 -0.7 -0.5325 -0.7537 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base O24 mock treatment 75040.0 -12000.0 -0.2 46760.0 -40300.0 -0.64 -0.5948 -0.8845 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P01 mock treatment 21760.0 -65300.0 -1.08 43040.0 -44000.0 -0.7 -1.2586 -0.9783 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P02 mock treatment 44360.0 -42700.0 -0.71 43600.0 -43500.0 -0.69 -0.9885 -1.0 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P03 mock treatment 55600.0 -31500.0 -0.52 39560.0 -47500.0 -0.76 -0.9029 -0.9831 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P04 mock treatment 66480.0 -20600.0 -0.34 35560.0 -51500.0 -0.82 -0.8209 -0.9239 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P05 mock treatment 84840.0 -2240.0 -0.04 27520.0 -59500.0 -0.95 -0.6973 -0.7341 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P06 mock treatment 110600.0 23500.0 0.39 27560.0 -59500.0 -0.95 -0.3961 -0.3865 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P07 mock treatment 115720.0 28600.0 0.47 27520.0 -59500.0 -0.95 -0.3368 -0.3177 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P08 mock treatment 96280.0 9200.0 0.15 35760.0 -51300.0 -0.82 -0.4709 -0.5661 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P09 mock treatment 97520.0 10400.0 0.17 36320.0 -50700.0 -0.81 -0.4501 -0.5443 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P10 mock treatment 109280.0 22200.0 0.37 21800.0 -65300.0 -1.04 -0.4764 -0.432 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P11 mock treatment 115440.0 28400.0 0.47 41640.0 -45400.0 -0.72 -0.1809 -0.2099 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P12 mock treatment 118360.0 31300.0 0.52 51200.0 -35900.0 -0.57 -0.0391 -0.0508 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P13 mock treatment 115160.0 28100.0 0.46 54480.0 -32600.0 -0.52 -0.0395 -0.0567 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P14 mock treatment 125280.0 38200.0 0.63 40040.0 -47000.0 -0.75 -0.0841 -0.0859 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P15 mock treatment 107640.0 20600.0 0.34 42400.0 -44700.0 -0.71 -0.2634 -0.334 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P16 mock treatment 98160.0 11100.0 0.18 32480.0 -54600.0 -0.87 -0.4859 -0.5465 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P17 mock treatment 100480.0 13400.0 0.22 36120.0 -50900.0 -0.81 -0.4178 -0.4964 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P18 mock treatment 117840.0 30800.0 0.51 33720.0 -53300.0 -0.85 -0.2422 -0.2446 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P19 mock treatment 81080.0 -6000.0 -0.1 30880.0 -56200.0 -0.9 -0.7033 -0.7806 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P20 mock treatment 60800.0 -26300.0 -0.43 27880.0 -59200.0 -0.94 -0.9738 -0.9379 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P21 mock treatment 67720.0 -19400.0 -0.32 33800.0 -53300.0 -0.85 -0.8263 -0.9109 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P22 mock treatment 62400.0 -24700.0 -0.41 32440.0 -54600.0 -0.87 -0.9037 -0.9402 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P23 mock treatment 50520.0 -36600.0 -0.6 40880.0 -46200.0 -0.74 -0.9473 -0.9951 1108.0005 CellTiterGlo(1108.0005) e-CadherinSyntheticLethalAssay 1108.0005.Base P24 mock treatment 22800.0 -64300.0 -1.06 41560.0 -45500.0 -0.73 -1.2632 -0.9828