ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A01 mock treatment 261880.0 12100.0 0.32 249280.0 -681.0 -0.02 0.2159 0.6682 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A02 mock treatment 274840.0 25100.0 0.67 266800.0 16800.0 0.43 0.7752 0.9769 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A03 compound treatment 286080.0 36300.0 0.97 260280.0 10300.0 0.26 0.8699 0.8675 985 SPBio_000001 Nc1ccc(C(=O)O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A04 compound treatment 273960.0 24200.0 0.64 263200.0 13200.0 0.34 0.6939 0.9541 1408 SPBio_000002 NC1(CC2CC3CC(C2)C1)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A05 compound treatment 282560.0 32800.0 0.87 256600.0 6640.0 0.17 0.7374 0.8284 1367 SPBio_000003 Cc1cc(O)ccc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A06 compound treatment 275440.0 25700.0 0.68 261120.0 11200.0 0.28 0.6844 0.9241 692 SPBio_000004 CC(=O)Nc1nnc(s1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A07 compound treatment 288920.0 39100.0 1.04 263440.0 13500.0 0.34 0.9802 0.8924 1001324 SPBio_000005 OC(=O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A08 compound treatment 288960.0 39200.0 1.04 274040.0 24100.0 0.61 1.1716 0.9676 2550 SPBio_000006 O[C@@H]([C@@H](COC(=O)CCC(=O)O)NC(=O)C(Cl)Cl)c1ccc(cc1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A09 compound treatment 267120.0 17300.0 0.46 284400.0 34400.0 0.88 0.9461 0.9554 3058614 SPBio_000007 C[C@@H](CO)NC(=O)C1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A10 compound treatment 297200.0 47400.0 1.26 270480.0 20500.0 0.52 1.2629 0.9234 760 SPBio_000008 N[C@@H]1CONC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A11 compound treatment 292280.0 42500.0 1.13 252920.0 2960.0 0.08 0.8544 0.7524 3199904 SPBio_000009 OC(=O)c1ccccc1OC(=O)/C=C/C(=O)Oc2ccccc2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A12 compound treatment 296520.0 46700.0 1.25 281680.0 31700.0 0.81 1.4515 0.9778 1267 SPBio_000010 CC(=O)Nc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A13 compound treatment 264880.0 15100.0 0.4 248880.0 -1080.0 -0.03 0.2652 0.6573 1300 SPBio_000011 OC(=O)c1cccnc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A14 compound treatment 299000.0 49200.0 1.31 262880.0 12900.0 0.33 1.1602 0.8576 1001897 SPBio_000012 CC(=O)N[C@@H](CS)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A15 compound treatment 15600.0 -234000.0 -6.24 13320.0 -237000.0 -6.02 -8.6697 -0.9998 3174099 SPBio_000013 Nc1cccc(c1)C(=C2C=CC(=N)C=C2)c3cccc(N)c3.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A16 compound treatment 281760.0 32000.0 0.85 297120.0 47200.0 1.2 1.4508 0.986 1037 SPBio_000014 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A17 compound treatment 300200.0 50400.0 1.34 285200.0 35200.0 0.9 1.5841 0.9806 1199 SPBio_000015 CSCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A18 compound treatment 273880.0 24100.0 0.64 272080.0 22100.0 0.56 0.852 0.9978 1108 SPBio_000016 Cc1cc(=O)n(c2ccccc2)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A19 compound treatment 283240.0 33500.0 0.89 277520.0 27600.0 0.7 1.1263 0.9929 1096 SPBio_000017 C[N+](C)(C)CC(O)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A20 compound treatment 282040.0 32300.0 0.86 285000.0 35000.0 0.89 1.2382 0.9998 1132 SPBio_000018 CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A21 compound treatment 119640.0 -130000.0 -3.47 152760.0 -97200.0 -2.47 -4.2012 -0.9862 3059433 SPBio_000019 CC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A22 compound treatment 294640.0 44900.0 1.2 287920.0 38000.0 0.97 1.5282 0.9943 697 SPBio_000020 Cn1c(=O)n(C)c2ncn(CC(O)CO)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A23 mock treatment 267400.0 17600.0 0.47 269480.0 19500.0 0.5 0.6831 0.9996 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 A24 mock treatment 253800.0 4020.0 0.11 242040.0 -7920.0 -0.2 -0.0666 -0.2922 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B01 mock treatment 275960.0 26200.0 0.7 268440.0 18500.0 0.47 0.8258 0.9815 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B02 mock treatment 281160.0 31400.0 0.84 271600.0 21600.0 0.55 0.9806 0.9793 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B03 compound treatment 263240.0 13500.0 0.36 243640.0 -6320.0 -0.16 0.1401 0.3563 2060046 SPBio_000021 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)[C@@]4(C)O[C@]43[C@H]2OC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B04 compound treatment 251280.0 1500.0 0.04 267600.0 17600.0 0.45 0.3454 0.7671 2060083 SPBio_000022 COC(=O)C(O)[C@H]1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B05 compound treatment 280200.0 30400.0 0.81 276240.0 26300.0 0.67 1.046 0.9954 2060226 SPBio_000023 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cc(cc34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B06 compound treatment 289920.0 40100.0 1.07 277400.0 27400.0 0.7 1.2501 0.9785 2060085 SPBio_000024 C[C@]12CCC3[C@@](C)([C@H](O)CC4[C@]3(C)C=CC(=O)OC4(C)C)C25OC5C(=O)O[C@H]1c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B07 compound treatment 240920.0 -8860.0 -0.24 261880.0 11900.0 0.3 0.0472 0.1229 2060422 SPBio_000025 CCOc1ccc(cc1)C(=O)c2cc(O)c(OC)c(OC)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B08 compound treatment 271400.0 21600.0 0.58 272880.0 22900.0 0.58 0.8197 1.0 2069252 SPBio_000026 CCC(C)C(OC(=O)C)C(=O)O[C@H]1[C@H](OC=O)C(C(=C)C2(O)C(=O)C[C@@H](c3ccoc3)[C@]12C)[C@]4(C)C(CC(=O)OC)[C@@](C)(COC(=O)C)OC(=O)C[C@@H]4OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B09 compound treatment 258800.0 9020.0 0.24 270560.0 20600.0 0.52 0.5404 0.9376 2060223 SPBio_000027 COc1cc(OC)c2C[C@H](O)[C@H](Oc2c1)c3ccc(OC)c(OC)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B10 compound treatment 264600.0 14800.0 0.4 278320.0 28400.0 0.72 0.7893 0.9599 2060087 SPBio_000028 COC(=O)C(O)[C@H]1C(C)(C)C(OC(=O)/C(=C/C)/C)[C@@H]2C=C3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B11 compound treatment 290960.0 41200.0 1.1 298240.0 48300.0 1.23 1.6444 0.9984 2060224 SPBio_000029 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B12 compound treatment 280640.0 30900.0 0.82 260800.0 10800.0 0.28 0.7767 0.8951 2060090 SPBio_000030 COC(=O)C[C@H]1C(C)(C)C(OC(=O)C)[C@]2(O)C=C3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B13 compound treatment 265640.0 15900.0 0.42 269760.0 19800.0 0.5 0.655 0.9962 2060169 SPBio_000031 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4c5c(O)c(O)c(O)cc5[C@H]6Oc7cc(O)cc(O)c7C[C@H]6OC(=O)c8cc(O)c(O)c(O)c8 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B14 compound treatment 290960.0 41200.0 1.1 276200.0 26200.0 0.67 1.2481 0.9715 2060089 SPBio_000032 CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@@H](OC(=O)CC32OC4(C)O[C@]53[C@H](OC(=O)C)[C@@]6(O)C(OC(=O)C7(C)OC7C)C8(C)CC6(O)[C@@](C)([C@H]8CC(=O)OC)[C@@]15O4)c9ccoc9 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B15 compound treatment 272160.0 22400.0 0.6 266800.0 16800.0 0.43 0.7247 0.9868 1254 SPBio_000033 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B16 compound treatment 19720.0 -230000.0 -6.13 19320.0 -231000.0 -5.86 -8.4842 -0.9997 2060091 SPBio_000034 CC(CC(O)C1OC1(C)C)[C@@H]2CCC3(C)C4=CCC5C(C)(C)C(=O)CCC5(C)C4CC[C@@]23C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B17 compound treatment 274400.0 24600.0 0.66 265200.0 15200.0 0.39 0.7381 0.9684 1859 SPBio_000035 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B18 compound treatment 17720.0 -232000.0 -6.19 18640.0 -231000.0 -5.88 -8.5341 -0.9997 2060093 SPBio_000036 CC([C@@H]1CC[C@]2(C)C3=CCC4C(C)(C)C(=O)CC[C@]4(C)C3CC[C@@]12C)C5OC(C)(C)C(O)C5O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B19 compound treatment 160360.0 -89400.0 -2.38 193800.0 -56200.0 -1.43 -2.6956 -0.97 2060218 SPBio_000037 COc1c(CC(=O)c2cc3CC(O)C(C)(C)Oc3cc2O)ccc4OC(C)(C)C=Cc14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B20 compound treatment 289680.0 39900.0 1.06 273360.0 23400.0 0.59 1.1729 0.9623 2060094 SPBio_000038 COC(=O)C(O)[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B21 compound treatment 99640.0 -150000.0 -4.0 16920.0 -233000.0 -5.93 -7.0206 -0.9818 3054028 SPBio_000039 CC(CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=C(CC[C@@]12C)C4(C)CC[C@H](O)C(C)(C)C4CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B22 compound treatment 256040.0 6260.0 0.17 236960.0 -13000.0 -0.33 -0.1158 -0.3126 2060115 SPBio_000040 CC(=CCOc1cc2oc(=O)ccc2cc1O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B23 mock treatment 271680.0 21900.0 0.58 282160.0 32200.0 0.82 0.9918 0.9863 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 B24 mock treatment 266200.0 16400.0 0.44 263200.0 13200.0 0.34 0.5476 0.9916 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C01 mock treatment 281120.0 31300.0 0.84 276800.0 26800.0 0.68 1.0734 0.995 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C02 mock treatment 254040.0 4260.0 0.11 273280.0 23300.0 0.59 0.4996 0.8275 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C03 compound treatment 251200.0 1420.0 0.04 248760.0 -1200.0 -0.03 0.0052 0.1061 2069233 SPBio_000041 COc1ccc2C3CCC4(C)C(O)[C@H](O)CC4C3CCc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C04 compound treatment 234600.0 -15200.0 -0.4 239880.0 -10100.0 -0.26 -0.4675 -0.9757 844 SPBio_000042 CNCCCN1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C05 compound treatment 212800.0 -37000.0 -0.99 206040.0 -43900.0 -1.12 -1.4869 -0.9981 2069241 SPBio_000043 COc1ccc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C06 compound treatment 250040.0 258.0 0.01 262480.0 12500.0 0.32 0.23 0.7222 678 SPBio_000044 NCC(CC(=O)O)c1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C07 compound treatment 239280.0 -10500.0 -0.28 237960.0 -12000.0 -0.31 -0.4138 -0.9991 1094519 SPBio_000045 CC(=O)N1CCCC1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C08 compound treatment 249520.0 -262.0 -0.01 254400.0 4440.0 0.11 0.0749 0.6622 1469 SPBio_000046 CCC1(CCC(=O)NC1=O)c2ccc(N)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C09 compound treatment 247040.0 -2740.0 -0.07 239640.0 -10300.0 -0.26 -0.2372 -0.8709 736 SPBio_000047 COC(=O)C(N)CS 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C10 compound treatment 245040.0 -4740.0 -0.13 259760.0 9800.0 0.25 0.0868 0.3106 1000124 SPBio_000048 CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C11 compound treatment 254720.0 4940.0 0.13 257640.0 7680.0 0.2 0.2312 0.9816 978 SPBio_000049 COC(=O)C(C)C[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C12 compound treatment 262240.0 12500.0 0.33 268720.0 18800.0 0.48 0.5722 0.9844 997 SPBio_000050 NCc1ccc(cc1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C13 compound treatment 271600.0 21800.0 0.58 259320.0 9360.0 0.24 0.5796 0.9222 2069271 SPBio_000051 C[C@H](N)[C@H](O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C14 compound treatment 266840.0 17100.0 0.45 252280.0 2320.0 0.06 0.3633 0.7922 1252 SPBio_000052 CC(C)NCC(O)c1cc(O)cc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C15 compound treatment 249120.0 -662.0 -0.02 263000.0 13000.0 0.33 0.222 0.6685 1404 SPBio_000053 Nc1ccc(N=Nc2ccccc2)c(N)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C16 compound treatment 85280.0 -165000.0 -4.39 81240.0 -169000.0 -4.29 -6.1349 -0.9999 1485 SPBio_000054 CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C17 compound treatment 249840.0 58.4 0.0 246480.0 -3480.0 -0.09 -0.0615 -0.6946 1090918 SPBio_000055 Cc1nc(C)c(Cl)c(O)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C18 compound treatment 242080.0 -7700.0 -0.21 240640.0 -9320.0 -0.24 -0.3128 -0.9975 1292 SPBio_000056 O=c1[nH]cnc2[nH]ncc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C19 compound treatment 256280.0 6500.0 0.17 248400.0 -1560.0 -0.04 0.0945 0.5314 3182 SPBio_000057 CCCc1cc(ccn1)C(=S)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C20 compound treatment 254920.0 5140.0 0.14 236320.0 -13600.0 -0.35 -0.1484 -0.3979 1332 SPBio_000058 NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C21 compound treatment 264200.0 14400.0 0.38 240960.0 -9000.0 -0.23 0.11 0.2459 3199905 SPBio_000059 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4c5nc6cc(C)ccn6c5c(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)C(O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)c(O)c4c(O)c3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C22 compound treatment 252800.0 3020.0 0.08 220240.0 -29700.0 -0.76 -0.4774 -0.6282 3177311 SPBio_000060 C[C@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C23 mock treatment 228160.0 -21600.0 -0.58 230040.0 -19900.0 -0.51 -0.7658 -0.9979 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 C24 mock treatment 241560.0 -8220.0 -0.22 238200.0 -11800.0 -0.3 -0.3665 -0.9883 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D01 mock treatment 269200.0 19400.0 0.52 249240.0 -721.0 -0.02 0.3531 0.6817 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D02 mock treatment 263920.0 14100.0 0.38 254120.0 4160.0 0.11 0.3413 0.8718 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D03 compound treatment 233360.0 -16400.0 -0.44 230160.0 -19800.0 -0.5 -0.6656 -0.9976 2069246 SPBio_000061 Cc1cc(O)c(C=O)c2Oc3c4C(O)OC(=O)c4c(O)c(C)c3OC(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D04 compound treatment 254720.0 4940.0 0.13 279600.0 29600.0 0.75 0.626 0.8183 2060364 SPBio_000062 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D05 compound treatment 194600.0 -55200.0 -1.47 172800.0 -77200.0 -1.96 -2.4276 -0.9899 3198309 SPBio_000063 CC(=O)OCC(O)CC(O)CCCCCCCCCCCC=C.CC(=O)OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D06 compound treatment 271240.0 21500.0 0.57 275280.0 25300.0 0.64 0.8598 0.9983 2060372 SPBio_000064 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3=C(CC[C@@]4(C)[C@@H](OC(=O)C=C34)c5ccoc5)[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D07 compound treatment 289400.0 39600.0 1.06 283840.0 33900.0 0.86 1.3561 0.9949 2060203 SPBio_000065 CCOC(=O)c1c(C)cc(O)c(C)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D08 compound treatment 259520.0 9740.0 0.26 269440.0 19500.0 0.5 0.5338 0.9546 2060145 SPBio_000066 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)C=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D09 compound treatment 263160.0 13400.0 0.36 266880.0 16900.0 0.43 0.5564 0.9957 2060100 SPBio_000067 OC(=O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D10 compound treatment 261160.0 11400.0 0.3 258720.0 8760.0 0.22 0.372 0.9885 2060127 SPBio_000068 COC1CC2=C3C[C@H]4C(=O)C(C)(C)[C@H](CC(=O)OC)[C@@](C)(C3CC[C@@]2(C)[C@@H](O1)c5ccoc5)C4=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D11 compound treatment 27640.0 -222000.0 -5.92 39360.0 -211000.0 -5.35 -7.9745 -0.9987 1017609 SPBio_000069 CC(=CCc1c(O)c2c(=O)c(coc2c3C=CC(C)(C)Oc13)c4ccc(O)cc4)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D12 compound treatment 279160.0 29400.0 0.78 275640.0 25700.0 0.65 1.0156 0.9959 2060118 SPBio_000070 COC(=O)CC1C(C)(C)C(O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D13 compound treatment 126760.0 -123000.0 -3.28 108680.0 -141000.0 -3.59 -4.8595 -0.999 2069330 SPBio_000071 COc1cc(O)c(C(=O)/C=C/c2ccccc2)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D14 compound treatment 257360.0 7580.0 0.2 277360.0 27400.0 0.7 0.6355 0.8761 2060121 SPBio_000072 COC(=O)C[C@H]1C(C)(C)C2(Cl)O[C@]34CC2C(=O)[C@]1(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C35)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D15 compound treatment 274080.0 24300.0 0.65 300960.0 51000.0 1.3 1.375 0.9486 2060495 SPBio_000073 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3c4c(O)c(O)c(O)cc4[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D16 compound treatment 268400.0 18600.0 0.5 264240.0 14300.0 0.36 0.6078 0.9882 2060150 SPBio_000074 CC1(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]3(C)OC(=O)CC12)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D17 compound treatment 21240.0 -229000.0 -6.09 59880.0 -190000.0 -4.83 -7.7263 -0.9934 3173879 SPBio_000075 CC(=CCc1c2OC(C)(C)C=Cc2c(OC(=O)C)c3c(=O)c(OC(=O)C)c(oc13)c4ccccc4)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D18 compound treatment 235240.0 -14500.0 -0.39 236840.0 -13100.0 -0.33 -0.5101 -0.9972 2060154 SPBio_000076 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D19 compound treatment 174680.0 -75100.0 -2.0 168920.0 -81000.0 -2.06 -2.873 -0.9999 3054809 SPBio_000077 COc1ccc2C(=O)C(Cc3ccc(OC)c(OC(=O)C)c3)COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D20 compound treatment 247480.0 -2300.0 -0.06 260360.0 10400.0 0.26 0.1436 0.5289 2060037 SPBio_000078 CC(=O)O[C@@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D21 compound treatment 260920.0 11100.0 0.3 256960.0 7000.0 0.18 0.3358 0.97 2060139 SPBio_000079 COc1ccc([C@@H]2COc3c(OC)c(OC)ccc3C2)c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D22 compound treatment 230840.0 -18900.0 -0.51 252960.0 3000.0 0.08 -0.3032 -0.5936 2060350 SPBio_000080 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D23 mock treatment 244360.0 -5420.0 -0.14 253040.0 3080.0 0.08 -0.0468 -0.285 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 D24 mock treatment 245160.0 -4620.0 -0.12 237200.0 -12800.0 -0.32 -0.3166 -0.9121 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E01 mock treatment 286560.0 36800.0 0.98 271400.0 21400.0 0.55 1.0789 0.9616 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E02 mock treatment 253120.0 3340.0 0.09 279760.0 29800.0 0.76 0.5987 0.7848 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E03 compound treatment 292320.0 42500.0 1.13 228600.0 -21400.0 -0.54 0.4179 0.3324 1014792 SPBio_000081 OC(=O)c1cc2ccccc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E04 compound treatment 254360.0 4580.0 0.12 248160.0 -1800.0 -0.05 0.0539 0.4138 1365 SPBio_000082 CN(C)CCC=C1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E05 compound treatment 246560.0 -3220.0 -0.09 260880.0 10900.0 0.28 0.1356 0.4665 3173210 SPBio_000083 CO/N=C(\C(=O)NC1[C@H]2SCC(=C(N2C1=O)C(=O)O)CSc3nc(=O)c(=O)[nH]n3C)/c4csc(N)n4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E06 compound treatment 282320.0 32500.0 0.87 301920.0 52000.0 1.32 1.5476 0.9792 3173722 SPBio_000084 NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)C3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E07 compound treatment 250240.0 458.0 0.01 285520.0 35600.0 0.9 0.648 0.7166 1310 SPBio_000085 NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H]([C@H](OP(=O)(O)O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E08 compound treatment 243360.0 -6420.0 -0.17 262440.0 12500.0 0.32 0.1033 0.2865 712 SPBio_000086 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSc3ccncc3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E09 compound treatment 26920.0 -223000.0 -5.94 26040.0 -224000.0 -5.69 -8.2276 -0.9998 1010201 SPBio_000087 ClC1=C(Cl)C(=O)C(=C(Cl)C1=O)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E10 compound treatment 280000.0 30200.0 0.81 296680.0 46700.0 1.19 1.4097 0.9821 679 SPBio_000088 CC(=O)Nc1cc(ccc1O)[As](=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E11 compound treatment 273880.0 24100.0 0.64 246600.0 -3360.0 -0.09 0.3939 0.6077 193 SPBio_000089 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E12 compound treatment 312320.0 62500.0 1.67 322880.0 72900.0 1.85 2.4901 0.9986 995 SPBio_000090 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@@H]([C@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E13 compound treatment 266360.0 16600.0 0.44 245720.0 -4240.0 -0.11 0.2363 0.5194 2801 SPBio_000091 CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E14 compound treatment 225280.0 -24500.0 -0.65 248200.0 -1760.0 -0.04 -0.4936 -0.7538 1141 SPBio_000092 CN1C2CCC1CC(C2)OC(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E15 compound treatment 239960.0 -9820.0 -0.26 290240.0 40300.0 1.02 0.539 0.5099 3199906 SPBio_000093 CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(=C/[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E16 compound treatment 259520.0 9740.0 0.26 412000.0 162000.0 4.12 3.097 0.7502 735 SPBio_000094 NNC(=O)c1ccncc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E17 compound treatment 252240.0 2460.0 0.07 257920.0 7960.0 0.2 0.1895 0.8906 2069298 SPBio_000095 CC(=O)Nc1c(I)cc(I)c(C(=O)O)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E18 compound treatment 241360.0 -8420.0 -0.22 283280.0 33300.0 0.85 0.4403 0.5024 1519 SPBio_000096 CC1(C)OC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E19 compound treatment 271280.0 21500.0 0.57 285640.0 35700.0 0.91 1.0468 0.9755 3173493 SPBio_000097 CC1=C2CCC3C4CCC(=O)[C@@]4(C)CCC3[C@@]2(C)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E20 compound treatment 260440.0 10700.0 0.28 267120.0 17200.0 0.44 0.5095 0.9784 1414 SPBio_000098 CC(=O)NO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E21 compound treatment 155800.0 -94000.0 -2.51 146920.0 -103000.0 -2.62 -3.6245 -0.9998 1467 SPBio_000099 CCCCOc1ccc(OCCCN2CCOCC2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E22 compound treatment 64440.0 -185000.0 -4.94 176320.0 -73600.0 -1.87 -4.8183 -0.9118 1035 SPBio_000100 Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E23 mock treatment 242000.0 -7780.0 -0.21 265480.0 15500.0 0.39 0.1323 0.2968 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 E24 mock treatment 245240.0 -4540.0 -0.12 265240.0 15300.0 0.39 0.1891 0.4647 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F01 mock treatment 281640.0 31900.0 0.85 271880.0 21900.0 0.56 0.9947 0.9791 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F02 mock treatment 257120.0 7340.0 0.2 250960.0 999.0 0.03 0.1563 0.7923 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F03 compound treatment 148800.0 -101000.0 -2.69 141400.0 -109000.0 -2.76 -3.8557 -0.9999 3173749 SPBio_000101 COc1cc2OC[C@H]3Oc4c5CC(Oc5ccc4C(=O)[C@H]3c2cc1OC)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F04 compound treatment 19960.0 -230000.0 -6.13 20960.0 -229000.0 -5.82 -8.4502 -0.9997 2060160 SPBio_000102 CC(=O)O[C@@H]1CC2C(C)(C)CCC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F05 compound treatment 258960.0 9180.0 0.24 338920.0 89000.0 2.26 1.7725 0.7791 1008719 SPBio_000103 COC(=O)C(O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F06 compound treatment 300360.0 50600.0 1.35 269640.0 19700.0 0.5 1.3074 0.9089 2060129 SPBio_000104 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F07 compound treatment 249040.0 -742.0 -0.02 268000.0 18000.0 0.46 0.3104 0.676 2060163 SPBio_000105 COc1ccc2C(=O)[C@@H]3[C@@H](COc4cc(OC)c(OC)cc34)Oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F08 compound treatment 262320.0 12500.0 0.33 249960.0 -0.625 0.0 0.2364 0.7071 2060365 SPBio_000106 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C3OC3[C@]2(C)C4CC[C@@]5(C)[C@@H](OC(=O)C6OC65[C@]14C)c7ccoc7 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F09 compound treatment 289000.0 39200.0 1.05 326280.0 76300.0 1.94 2.1116 0.9579 2060165 SPBio_000107 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F10 compound treatment 296280.0 46500.0 1.24 285800.0 35800.0 0.91 1.521 0.9885 2060162 SPBio_000108 COC(=O)C[C@H]1C(C)(C)[C@@H](O)[C@@H]2CC3=C4C=C(OC)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F11 compound treatment 237920.0 -11900.0 -0.32 274680.0 24700.0 0.63 0.2208 0.3138 1372522 SPBio_000109 COc1ccc(cc1)c2coc3cc(OC)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F12 compound treatment 319720.0 69900.0 1.86 266720.0 16800.0 0.43 1.6199 0.8469 2060177 SPBio_000110 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]2(C)[C@H]7O[C@H]7C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F13 compound treatment 236560.0 -13200.0 -0.35 249120.0 -841.0 -0.02 -0.2644 -0.7486 2069309 SPBio_000111 COc1cc2OC[C@H]3Oc4c5CCC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F14 compound treatment 342280.0 92500.0 2.47 260200.0 10200.0 0.26 1.928 0.7774 2060320 SPBio_000112 COc1ccc2CC[C@@H]3CC(=O)CC[C@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F15 compound treatment 255480.0 5700.0 0.15 311680.0 61700.0 1.57 1.2171 0.772 2060494 SPBio_000113 COc1ccc2C(=O)C(Cc3ccc(OC)c(OC)c3)COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F16 compound treatment 22400.0 -227000.0 -6.06 25240.0 -225000.0 -5.71 -8.3272 -0.9996 3173369 SPBio_000114 CC(C)c1c(OC(=O)C)ccc2c1CCC3C(C)(C)CCC[C@@]32C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F17 compound treatment 261040.0 11300.0 0.3 284440.0 34500.0 0.88 0.8322 0.898 2060110 SPBio_000115 COc1ccc(c(OC)c1)c2coc3cc(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F18 compound treatment 19960.0 -230000.0 -6.13 21760.0 -228000.0 -5.8 -8.4358 -0.9996 2060034 SPBio_000116 CC(C)c1c(O)ccc2c1CCC3[C@](C)(CCC[C@@]32C)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F19 compound treatment 171880.0 -77900.0 -2.08 176080.0 -73900.0 -1.88 -2.797 -0.9987 2060102 SPBio_000117 COc1ccc2C(=O)c3cc(OC)c(OC)cc3CC(=O)COc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F20 compound treatment 41840.0 -208000.0 -5.54 53520.0 -196000.0 -4.99 -7.4522 -0.9986 2060126 SPBio_000118 CC(C)c1c(O)ccc2c1CCC3[C@@](C)(CO)CCC[C@@]32C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F21 compound treatment 263040.0 13300.0 0.35 381080.0 131000.0 3.33 2.6074 0.7777 1059133 SPBio_000119 COc1ccc(C(=O)c2ccccc2)c(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F22 compound treatment 236640.0 -13100.0 -0.35 386280.0 136000.0 3.47 2.2032 0.6324 3053987 SPBio_000120 CC(=O)C1CC[C@H]2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F23 mock treatment 238160.0 -11600.0 -0.31 268920.0 19000.0 0.48 0.1218 0.2125 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 F24 mock treatment 234880.0 -14900.0 -0.4 254840.0 4880.0 0.12 -0.1932 -0.4642 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G01 mock treatment 259560.0 9780.0 0.26 277800.0 27800.0 0.71 0.6849 0.9079 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G02 mock treatment 243960.0 -5820.0 -0.16 250000.0 39.4 0.0 -0.109 -0.7025 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G03 compound treatment 235040.0 -14700.0 -0.39 258360.0 8400.0 0.21 -0.1269 -0.2837 2060144 SPBio_000121 COc1cccc(c1)c2cc(=O)c3cc(OC)ccc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G04 compound treatment 287000.0 37200.0 0.99 266080.0 16100.0 0.41 0.9915 0.9235 696 SPBio_000122 Oc1cccc2Cc3cccc(O)c3C(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G05 compound treatment 260400.0 10600.0 0.28 261160.0 11200.0 0.28 0.4015 1.0 3077146 SPBio_000123 CN[C@@H]1[C@@H](O)C(OC2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)OC[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G06 compound treatment 253520.0 3740.0 0.1 281200.0 31200.0 0.79 0.6321 0.7896 1124 SPBio_000124 CN1C2CC[C@@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G07 compound treatment 241640.0 -8140.0 -0.22 257400.0 7440.0 0.19 -0.0197 -0.0686 3077147 SPBio_000125 CC(O)Cn1c(C)ncc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G08 compound treatment 24040.0 -226000.0 -6.02 25200.0 -225000.0 -5.71 -8.297 -0.9997 1247 SPBio_000126 Oc1c(Cl)cc(Cl)cc1Sc2cc(Cl)cc(Cl)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G09 compound treatment 302440.0 52700.0 1.4 254400.0 4440.0 0.11 1.0726 0.7615 1461079 SPBio_000127 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCN(C)CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G10 compound treatment 267800.0 18000.0 0.48 256360.0 6400.0 0.16 0.4548 0.8966 1327 SPBio_000128 C[N+](C)(C)CCOC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G11 compound treatment 69240.0 -181000.0 -4.81 29240.0 -221000.0 -5.61 -7.3722 -0.9971 3480340 SPBio_000129 c1cn(cn1)C(c2ccccc2)c3ccc(cc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G12 compound treatment 288720.0 38900.0 1.04 260000.0 10000.0 0.26 0.9146 0.8555 1432 SPBio_000130 CN(C)CCOC(C)(c1ccccc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G13 compound treatment 286320.0 36500.0 0.97 253640.0 3680.0 0.09 0.755 0.7715 3199907 SPBio_000131 OC(=O)c1cn(c2ccc(F)cc2)c3cc(N4CCNCC4)c(F)cc3c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G14 compound treatment 269240.0 19500.0 0.52 262120.0 12200.0 0.31 0.5855 0.9694 873 SPBio_000132 Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CNc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G15 compound treatment 203880.0 -45900.0 -1.22 218680.0 -31300.0 -0.8 -1.4278 -0.9782 1007083 SPBio_000133 Oc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G16 compound treatment 215040.0 -34700.0 -0.93 225080.0 -24900.0 -0.63 -1.1023 -0.9827 1513 SPBio_000134 CCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G17 compound treatment 224760.0 -25000.0 -0.67 281040.0 31100.0 0.79 0.087 0.0842 1008492 SPBio_000135 O=C(CC(=O)c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G18 compound treatment 239600.0 -10200.0 -0.27 270080.0 20100.0 0.51 0.1698 0.2932 1000042 SPBio_000136 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G19 compound treatment 259400.0 9620.0 0.26 259400.0 9440.0 0.24 0.3511 0.9995 3480338 SPBio_000137 OC(=O)C(Cc1cc(=O)[nH]c2ccccc12)NC(=O)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G20 compound treatment 240440.0 -9340.0 -0.25 261440.0 11500.0 0.29 0.0303 0.0789 3172713 SPBio_000138 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C)\c3csc(N)n3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G21 compound treatment 100400.0 -149000.0 -3.98 127560.0 -122000.0 -3.11 -5.017 -0.9926 903 SPBio_000139 COC(=O)Nc1nc2ccc(Sc3ccccc3)cc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G22 compound treatment 252360.0 2580.0 0.07 259360.0 9400.0 0.24 0.2176 0.875 1336 SPBio_000140 CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G23 mock treatment 243240.0 -6540.0 -0.17 279960.0 30000.0 0.76 0.416 0.5317 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 G24 mock treatment 230640.0 -19100.0 -0.51 260240.0 10300.0 0.26 -0.1761 -0.3071 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H01 mock treatment 257800.0 8020.0 0.21 253560.0 3600.0 0.09 0.2159 0.9283 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H02 mock treatment 243880.0 -5900.0 -0.16 245240.0 -4720.0 -0.12 -0.1961 -0.9911 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H03 compound treatment 249680.0 -102.0 0.0 256280.0 6320.0 0.16 0.1117 0.6951 2060106 SPBio_000141 COc1cc(cc(OC)c1OC)c2coc3cc(OC)c(OC)c(OC)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H04 compound treatment 21080.0 -229000.0 -6.1 20280.0 -230000.0 -5.84 -8.4413 -0.9998 3173992 SPBio_000142 CC(C)c1c(O)ccc2c1CCC3C(C)(C)CCC[C@@]32C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H05 compound treatment 291800.0 42000.0 1.12 309160.0 59200.0 1.51 1.8565 0.9894 3054981 SPBio_000143 COc1ccc(cc1)c2cc(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H06 compound treatment 260440.0 10700.0 0.28 279080.0 29100.0 0.74 0.7245 0.9135 2060280 SPBio_000144 C[C@H]1C2C(CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4CC[C@]23C)OC(=O)C)O[C@]61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H07 compound treatment 208440.0 -41300.0 -1.1 204160.0 -45800.0 -1.16 -1.6029 -0.9996 3054030 SPBio_000145 Oc1cc(O)cc(/C=C/c2ccccc2)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H08 compound treatment 242080.0 -7700.0 -0.21 264000.0 14000.0 0.36 0.1072 0.2604 3174366 SPBio_000146 C[C@H]1C2C(CC3C4CC[C@@H]5C[C@H](CC[C@]5(C)C4CC[C@]23C)OC(=O)C)O[C@]61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H09 compound treatment 280640.0 30900.0 0.82 343120.0 93200.0 2.37 2.2567 0.9 3055207 SPBio_000147 COc1cc(O)cc(/C=C/c2ccccc2)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H10 compound treatment 264920.0 15100.0 0.4 234640.0 -15300.0 -0.39 0.01 0.0177 2060351 SPBio_000148 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4=CC(=O)[C@]23C)OC(=O)C)OC61OCC(C)CC6Br 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H11 compound treatment 278000.0 28200.0 0.75 324960.0 75000.0 1.91 1.8804 0.9173 3054032 SPBio_000149 COc1cc(C/C=C/c2ccccc2)c(OC)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H12 compound treatment 271880.0 22100.0 0.59 236360.0 -13600.0 -0.35 0.1721 0.2519 2060188 SPBio_000150 C[C@H]1C2C(CC3C4CCC5C[C@@H](O)CCC5(C)C4=CCC23C)OC61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H13 compound treatment 268240.0 18500.0 0.49 294240.0 44300.0 1.13 1.1441 0.9311 2060259 SPBio_000151 COc1ccc2c(=O)c(CC(=O)O)coc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H14 compound treatment 301240.0 51500.0 1.37 277760.0 27800.0 0.71 1.47 0.9524 3173999 SPBio_000152 C[C@H]1C2C(CC3C4CC[C@H]5CC(CCC5(C)C4CC(=O)C23C)OC(=O)C)OC61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H15 compound treatment 186280.0 -63500.0 -1.69 188320.0 -61600.0 -1.57 -2.3055 -0.9993 2060294 SPBio_000153 COc1ccc2C(=O)C(Cc3ccc(OC)c(O)c3)COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H16 compound treatment 304240.0 54500.0 1.45 283720.0 33800.0 0.86 1.6337 0.9685 3054097 SPBio_000154 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H17 compound treatment 251440.0 1660.0 0.04 269720.0 19800.0 0.5 0.3865 0.7664 2060133 SPBio_000155 COc1cc(cc(O)c1OC)c2coc3cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(O)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H18 compound treatment 18760.0 -231000.0 -6.16 18600.0 -231000.0 -5.88 -8.5152 -0.9997 3173995 SPBio_000156 C[C@H]1C2C(O[C@@]31CC[C@@H](C)CO3)C(O)C4C5CC[C@H]6C[C@H](O[C@@H]7O[C@H](CO)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@H]8O[C@@H]%10O[C@H](CO)[C@H](O)[C@H](O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%11O)[C@H]%10O)[C@H](O)[C@H]7O)[C@H](O)C[C@]6(C)C5CC[C@]24C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H19 compound treatment 276920.0 27100.0 0.72 283960.0 34000.0 0.86 1.1229 0.9961 3054129 SPBio_000157 CO[C@@H]1CC2N3CC(O)C2(C=C1)c4cc5OCOc5c(OC)c4C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H20 compound treatment 267960.0 18200.0 0.48 268080.0 18100.0 0.46 0.6685 0.9997 1355 SPBio_000158 CC(C)(O)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@@]53C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H21 compound treatment 243480.0 -6300.0 -0.17 258160.0 8200.0 0.21 0.0286 0.1069 2060069 SPBio_000159 COc1cc(cc(O)c1OC)c2coc3cc(OCc4ccccc4)c(OC)c(O)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H22 compound treatment 258400.0 8620.0 0.23 263880.0 13900.0 0.35 0.4127 0.9781 2060207 SPBio_000160 CC1(C)[C@H](O)C[C@H](O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H23 mock treatment 230480.0 -19300.0 -0.51 265160.0 15200.0 0.39 -0.0906 -0.1408 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 H24 mock treatment 240040.0 -9740.0 -0.26 213280.0 -36700.0 -0.93 -0.8432 -0.8709 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I01 mock treatment 241200.0 -8580.0 -0.23 227640.0 -22300.0 -0.57 -0.5631 -0.9202 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I02 mock treatment 244240.0 -5540.0 -0.15 267440.0 17500.0 0.44 0.2098 0.4479 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I03 compound treatment 253840.0 4060.0 0.11 248360.0 -1600.0 -0.04 0.0477 0.4129 2060260 SPBio_000161 COc1ccc(cc1)C2CC(=O)c3ccc(OC)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I04 compound treatment 251600.0 1820.0 0.05 271360.0 21400.0 0.54 0.419 0.7671 759 SPBio_000162 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I05 compound treatment 244040.0 -5740.0 -0.15 259600.0 9640.0 0.25 0.0651 0.2251 2335 SPBio_000163 COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I06 compound treatment 237480.0 -12300.0 -0.33 260760.0 10800.0 0.27 -0.0378 -0.0883 807 SPBio_000164 CCCc1ncc(C[n+]2ccccc2C)c(N)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I07 compound treatment 242600.0 -7180.0 -0.19 263880.0 13900.0 0.35 0.1149 0.2854 1025940 SPBio_000165 Cc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I08 compound treatment 246760.0 -3020.0 -0.08 276600.0 26600.0 0.68 0.422 0.6186 1381 SPBio_000166 Nc1ccc(cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I09 compound treatment 262440.0 12700.0 0.34 288440.0 38500.0 0.98 0.9305 0.899 2516 SPBio_000167 CC(C)OC(=O)Nc1cccc(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I10 compound treatment 254520.0 4740.0 0.13 261040.0 11100.0 0.28 0.2885 0.9345 1303 SPBio_000168 C[N+]1(CCC2CC1)CC2OC(=O)C(O)(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I11 compound treatment 253680.0 3900.0 0.1 282880.0 32900.0 0.84 0.6654 0.7889 2069315 SPBio_000169 COc1cc(OC)c2c(=O)c(coc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I12 compound treatment 250440.0 658.0 0.02 278520.0 28600.0 0.73 0.5259 0.724 1019 SPBio_000170 NC(=O)N1c2ccccc2C=Cc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I13 compound treatment 218440.0 -31300.0 -0.84 129280.0 -121000.0 -3.07 -2.7606 -0.8681 2060112 SPBio_000171 COc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I14 compound treatment 81560.0 -168000.0 -4.49 244480.0 -5480.0 -0.14 -3.2701 -0.7287 1400 SPBio_000172 CC(C)[C@@H](C)/C=C/[C@@H](C)C1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)CCC3=C)\CCC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I15 compound treatment 187120.0 -62700.0 -1.67 136040.0 -114000.0 -2.9 -3.2296 -0.9658 1602 SPBio_000173 COc1ccc(cc1)c2coc3cc(O)cc(O)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I16 compound treatment 241440.0 -8340.0 -0.22 256600.0 6640.0 0.17 -0.0379 -0.1357 1000114 SPBio_000174 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I17 compound treatment 17200.0 -233000.0 -6.2 18600.0 -231000.0 -5.88 -8.5446 -0.9997 2069308 SPBio_000175 CC(=CCc1c(O)cc2occ(c3ccc4OCOc4c3)c(=O)c2c1O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I18 compound treatment 24240.0 -226000.0 -6.01 15320.0 -235000.0 -5.97 -8.4709 -1.0 1272 SPBio_000176 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I19 compound treatment 227080.0 -22700.0 -0.61 250720.0 759.0 0.02 -0.4143 -0.6842 1534 SPBio_000177 O=C(/C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I20 compound treatment 231600.0 -18200.0 -0.48 266200.0 16200.0 0.41 -0.0508 -0.0798 1000138 SPBio_000178 CC(C)Cc1ccc(cc1)C(C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I21 compound treatment 233640.0 -16100.0 -0.43 222040.0 -27900.0 -0.71 -0.8063 -0.9712 2060354 SPBio_000179 COc1ccc(cc1)c2coc3cc(OC(=O)C)cc(OC(=O)C)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I22 compound treatment 157880.0 -91900.0 -2.45 147680.0 -102000.0 -2.6 -3.5716 -0.9996 1157 SPBio_000180 CC(=O)N1CCN(CC1)c2ccc(OCC3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I23 mock treatment 251400.0 1620.0 0.04 274400.0 24400.0 0.62 0.4699 0.7544 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 I24 mock treatment 228480.0 -21300.0 -0.57 206160.0 -43800.0 -1.11 -1.1891 -0.9512 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J01 mock treatment 251400.0 1620.0 0.04 242720.0 -7240.0 -0.18 -0.0997 -0.5271 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J02 mock treatment 253200.0 3420.0 0.09 248920.0 -1040.0 -0.03 0.0457 0.4819 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J03 compound treatment 240960.0 -8820.0 -0.24 134160.0 -116000.0 -2.94 -2.2483 -0.7612 2120750 SPBio_000181 CC(C)C(C)/C=C/C(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J04 compound treatment 244160.0 -5620.0 -0.15 261600.0 11600.0 0.3 0.1033 0.3113 2060212 SPBio_000182 CC1(C)[C@H](O)CC(=O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J05 compound treatment 266440.0 16700.0 0.44 271600.0 21600.0 0.55 0.7031 0.9944 2060070 SPBio_000183 COc1c(O)cc(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J06 compound treatment 136520.0 -113000.0 -3.02 118880.0 -131000.0 -3.33 -4.4921 -0.9988 3054128 SPBio_000184 COC1C[C@H]2N3CC(O)C2(C=C1)c4cc5OCOc5cc4C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J07 compound treatment 32200.0 -218000.0 -5.8 46720.0 -203000.0 -5.17 -7.7562 -0.9983 3177381 SPBio_000185 Oc1ccc(cc1)C(=O)/C=C/c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J08 compound treatment 257960.0 8180.0 0.22 269720.0 19800.0 0.5 0.5094 0.9302 2060036 SPBio_000186 CC1=CCc2c(O)c3c(=O)cc(C)oc3cc2OC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J09 compound treatment 273000.0 23200.0 0.62 273080.0 23100.0 0.59 0.8534 0.9997 2060263 SPBio_000187 COc1ccc(C(=O)c2ccc(O)cc2)c(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J10 compound treatment 305160.0 55400.0 1.48 283560.0 33600.0 0.85 1.6482 0.9662 2060187 SPBio_000188 COc1cccc(/C=C/C(=O)O)c1C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J11 compound treatment 263880.0 14100.0 0.38 258920.0 8960.0 0.23 0.4269 0.9712 1032994 SPBio_000189 O=C1CC(Oc2ccccc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J12 compound treatment 348080.0 98300.0 2.62 238360.0 -11600.0 -0.29 1.6447 0.6236 2060117 SPBio_000190 Cc1ccc2c(CC[C@H]3CC(=O)CC[C@@]32C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J13 compound treatment 257600.0 7820.0 0.21 264080.0 14100.0 0.36 0.4013 0.9666 2060208 SPBio_000191 COC(=O)C[C@H]1C(C)(C)[C@@H](O)[C@@H]2CC3=C4CC(O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J14 compound treatment 272800.0 23000.0 0.61 278240.0 28300.0 0.72 0.9424 0.9969 2060158 SPBio_000192 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](OC(=O)C)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J15 compound treatment 237880.0 -11900.0 -0.32 255320.0 5360.0 0.14 -0.128 -0.3707 3058620 SPBio_000193 O[C@@H](C(=O)O)[C@@](O)(Cc1ccc(O)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J16 compound treatment 254600.0 4820.0 0.13 258080.0 8120.0 0.21 0.2368 0.974 2060153 SPBio_000194 COc1cccc2c1CCC3=CC(=O)CC[C@@]32C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J17 compound treatment 197240.0 -52500.0 -1.4 199320.0 -50600.0 -1.29 -1.9011 -0.9991 2060238 SPBio_000195 Cc1cc(O)cc(O)c1C(=O)Oc2cc(C)c(C(=O)Oc3cc(C)c(C(=O)O)c(O)c3)c(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J18 compound treatment 64000.0 -186000.0 -4.95 55240.0 -195000.0 -4.95 -7.0035 -1.0 3173991 SPBio_000196 C[C@@]12CCC3C(CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)C[C@H](O)[C@@H]1C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J19 compound treatment 54760.0 -195000.0 -5.2 78800.0 -171000.0 -4.35 -6.7541 -0.9961 2060216 SPBio_000197 COc1cc2OC[C@H]3Oc4c(ccc5oc(cc45)C(C)C)C(=O)[C@H]3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J20 compound treatment 17040.0 -233000.0 -6.21 19440.0 -231000.0 -5.86 -8.5325 -0.9996 2060214 SPBio_000198 COc1c(ccc2OC(C)(C)C=Cc12)c3coc4cc5OC(C)(C)C(O)Cc5cc4c3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J21 compound treatment 286320.0 36500.0 0.97 264080.0 14100.0 0.36 0.9427 0.908 2060242 SPBio_000199 COc1ccc(cc1)c2cc(=O)c3c(O)c(OC)c(O[C@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J22 compound treatment 202400.0 -47400.0 -1.26 204120.0 -45800.0 -1.17 -1.7175 -0.9992 3077173 SPBio_000200 CCOc1ccc(cc1)C(=O)c2ccc(OC)c(O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J23 mock treatment 238000.0 -11800.0 -0.31 273760.0 23800.0 0.61 0.2058 0.3018 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 J24 mock treatment 245040.0 -4740.0 -0.13 255480.0 5520.0 0.14 0.0098 0.0521 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K01 mock treatment 207280.0 -42500.0 -1.13 207640.0 -42300.0 -1.08 -1.5622 -0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K02 mock treatment 245200.0 -4580.0 -0.12 267920.0 18000.0 0.46 0.2365 0.5004 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K03 compound treatment 280640.0 30900.0 0.82 296760.0 46800.0 1.19 1.4232 0.9838 1403 SPBio_000201 COC(=O)C1=CCCN(C)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K04 compound treatment 289280.0 39500.0 1.05 284520.0 34600.0 0.88 1.366 0.9959 1167 SPBio_000202 NCCCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K05 compound treatment 256000.0 6220.0 0.17 288040.0 38100.0 0.97 0.8019 0.8163 1013706 SPBio_000203 O=c1c2ccccc2oc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K06 compound treatment 232680.0 -17100.0 -0.46 285120.0 35200.0 0.89 0.3097 0.3086 834 SPBio_000204 CC(C[N+](C)(C)C)OC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K07 compound treatment 207360.0 -42400.0 -1.13 249360.0 -601.0 -0.02 -0.8106 -0.7166 592 SPBio_000205 Oc1ccc(cc1)c2coc3cc(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K08 compound treatment 227200.0 -22600.0 -0.6 273640.0 23700.0 0.6 0.0 0.0 1059 SPBio_000206 CN(C)CC/C=C\1/c2ccccc2COc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K09 compound treatment 120160.0 -130000.0 -3.46 103120.0 -147000.0 -3.73 -5.0839 -0.9993 2069329 SPBio_000207 COc1cc(O)c2c(=O)cc(oc2c1)c3ccc(OC)c(c3)c4c(O)cc(O)c5c(=O)cc(oc45)c6ccc(O)cc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K10 compound treatment 21000.0 -229000.0 -6.1 19240.0 -231000.0 -5.87 -8.4615 -0.9998 1373 SPBio_000208 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K11 compound treatment 320360.0 70600.0 1.88 241160.0 -8800.0 -0.22 1.1724 0.6187 2069249 SPBio_000209 COc1ccc(cc1)c2coc3c(O)c(OC)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K12 compound treatment 191280.0 -58500.0 -1.56 95120.0 -155000.0 -3.94 -3.8869 -0.9178 1360 SPBio_000210 Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K13 compound treatment 301440.0 51700.0 1.38 239520.0 -10400.0 -0.27 0.7862 0.5605 1250 SPBio_000211 COc1cc(C)c2c(=O)cc(oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K14 compound treatment 252640.0 2860.0 0.08 255160.0 5200.0 0.13 0.1474 0.9658 1396 SPBio_000212 Cc1cc(O)cc(C)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K15 compound treatment 110440.0 -139000.0 -3.72 116560.0 -133000.0 -3.39 -5.0255 -0.999 1672652 SPBio_000213 COc1ccc(cc1)c2cc(=O)c3ccc(OC)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K16 compound treatment 231120.0 -18700.0 -0.5 263000.0 13000.0 0.33 -0.1174 -0.1963 2069266 SPBio_000214 CNC(C)[C@H](O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K17 compound treatment 232840.0 -16900.0 -0.45 219160.0 -30800.0 -0.78 -0.8732 -0.9658 2069226 SPBio_000215 COc1ccc2-c3oc4cc(OC)ccc4c3COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K18 compound treatment 237600.0 -12200.0 -0.32 271040.0 21100.0 0.54 0.1493 0.2383 1445 SPBio_000216 C/C=C(/C)\C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@@H]4[C@@]2(C[C@@]5(O)[C@@H]6CN7C[C@@H](C)CC[C@H]7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]45O)O[C@@]31O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K19 compound treatment 132880.0 -117000.0 -3.12 164440.0 -85500.0 -2.17 -3.7416 -0.9845 353 SPBio_000217 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K20 compound treatment 162800.0 -87000.0 -2.32 190560.0 -59400.0 -1.51 -2.7079 -0.9784 1476 SPBio_000218 CNCCCC1(CCC2c3ccccc31)c4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K21 compound treatment 96720.0 -153000.0 -4.08 110680.0 -139000.0 -3.54 -5.3899 -0.9975 1116 SPBio_000219 S=c1[nH]cnc2nc[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K22 compound treatment 201760.0 -48000.0 -1.28 222280.0 -27700.0 -0.7 -1.403 -0.9603 1095 SPBio_000220 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K23 mock treatment 343240.0 93500.0 2.49 231280.0 -18700.0 -0.47 1.4261 0.5622 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 K24 mock treatment 225400.0 -24400.0 -0.65 231280.0 -18700.0 -0.47 -0.7955 -0.9881 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L01 mock treatment 213920.0 -35900.0 -0.96 212200.0 -37800.0 -0.96 -1.355 -1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L02 mock treatment 272720.0 22900.0 0.61 263240.0 13300.0 0.34 0.6712 0.9608 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L03 compound treatment 270440.0 20700.0 0.55 255600.0 5640.0 0.14 0.4909 0.8624 1090422 SPBio_000221 Cc1cc(O)cc(O)c1C(=O)Oc2cc(C)c(C(=O)O)c(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L04 compound treatment 277120.0 27300.0 0.73 256280.0 6320.0 0.16 0.629 0.8427 3077174 SPBio_000222 CC(=O)Oc1ccc(cc1)c2cc(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L05 compound treatment 279880.0 30100.0 0.8 281600.0 31600.0 0.8 1.1363 1.0 2060043 SPBio_000223 COc1cc(OC)c(Cl)c2OC3(C(C)CC(=O)C=C3O)C(=O)c21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L06 compound treatment 100600.0 -149000.0 -3.98 68880.0 -181000.0 -4.6 -6.0683 -0.9973 3077175 SPBio_000224 COc1ccc2C(=O)/C(=C\c3ccc(O)c(O)c3)/COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L07 compound treatment 215920.0 -33900.0 -0.9 200200.0 -49800.0 -1.27 -1.5331 -0.9863 812 SPBio_000225 COC1=CC(=O)C[C@@H](C)[C@@]21Oc3c(C2=O)c(OC)cc(OC)c3Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L08 compound treatment 289160.0 39400.0 1.05 296440.0 46500.0 1.18 1.5781 0.9983 3054572 SPBio_000226 CC(=O)O[C@@H]1CC[C@@]2(C)C(CC[C@]3(C)C2CC=C4C5CC(C)(C)CC[C@@]5(CC[C@]43C)C(=O)O)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L09 compound treatment 258640.0 8860.0 0.24 232640.0 -17300.0 -0.44 -0.1444 -0.289 1051460 SPBio_000227 COc1cc(C(=O)O)c2Oc3c(C=O)c(O)cc(C)c3C(=O)Oc2c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L10 compound treatment 94720.0 -155000.0 -4.13 75400.0 -175000.0 -4.44 -6.0619 -0.9994 2060234 SPBio_000228 COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L11 compound treatment 237480.0 -12300.0 -0.33 271680.0 21700.0 0.55 0.1586 0.2469 2060040 SPBio_000229 CCOC(=O)C1(O)Oc2cc(OC)cc(OC)c2C(=O)C1c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L12 compound treatment 18640.0 -231000.0 -6.16 16520.0 -233000.0 -5.94 -8.5549 -0.9998 2069327 SPBio_000230 COC/1=CC(=O)C(=C\C1=C/C=C/c2ccccc2)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L13 compound treatment 58440.0 -191000.0 -5.1 74400.0 -176000.0 -4.46 -6.7639 -0.9978 2069243 SPBio_000231 O/C(=C\C(=O)c1ccccc1O)/c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L14 compound treatment 143920.0 -106000.0 -2.82 141920.0 -108000.0 -2.75 -3.9383 -0.9999 3173492 SPBio_000232 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(O)ccc3-c2c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L15 compound treatment 261720.0 11900.0 0.32 242760.0 -7200.0 -0.18 0.0956 0.2604 2060463 SPBio_000233 COc1ccc(cc1)c2coc3c(OC)c(OC)cc(O)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L16 compound treatment 17800.0 -232000.0 -6.19 22080.0 -228000.0 -5.79 -8.4707 -0.9995 2081025 SPBio_000234 C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L17 compound treatment 245600.0 -4180.0 -0.11 272280.0 22300.0 0.57 0.3224 0.5575 3172979 SPBio_000235 C[C@H]1C2C(CC3C4CC=C5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L18 compound treatment 172800.0 -77000.0 -2.05 177960.0 -72000.0 -1.83 -2.7459 -0.9984 3058525 SPBio_000236 COc1cc2OC[C@H]3Oc4c5C=CC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L19 compound treatment 252160.0 2380.0 0.06 266480.0 16500.0 0.42 0.3418 0.8047 923 SPBio_000237 NC(=O)NC1NC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L20 compound treatment 247080.0 -2700.0 -0.07 229760.0 -20200.0 -0.51 -0.4141 -0.7985 3077176 SPBio_000238 COc1ccc(c(O)c1O)c2coc3cc(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L21 compound treatment 252520.0 2740.0 0.07 347400.0 97400.0 2.48 1.8035 0.7276 3198310 SPBio_000239 COc1ccc([C@H]2COc3c(OC)c(O)ccc3C2)c(OC)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L22 compound treatment 51880.0 -198000.0 -5.28 37920.0 -212000.0 -5.39 -7.5434 -0.9999 3077177 SPBio_000240 CC(=O)OCC(O)CC(=O)CCCCCCCCCCCC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L23 mock treatment 273200.0 23400.0 0.62 258080.0 8120.0 0.21 0.5875 0.8933 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 L24 mock treatment 256240.0 6460.0 0.17 229880.0 -20100.0 -0.51 -0.2393 -0.4441 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M01 mock treatment 234760.0 -15000.0 -0.4 218000.0 -32000.0 -0.81 -0.8578 -0.9469 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M02 mock treatment 232240.0 -17500.0 -0.47 238440.0 -11500.0 -0.29 -0.5378 -0.9746 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M03 compound treatment 253880.0 4100.0 0.11 235000.0 -15000.0 -0.38 -0.1917 -0.4844 3177464 SPBio_000241 NCCCC(N)CC(=O)NCC1NC(=O)C(CO)NC(=O)C(N)CNC(=O)C(NC(=O)/C(=C\NC(=O)N)/NC1=O)C2CCNC(=N)N2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M04 compound treatment 245080.0 -4700.0 -0.13 207200.0 -42800.0 -1.09 -0.8574 -0.7834 984 SPBio_000242 C[C@H]1CC2C3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)C2[C@@]4(C)CCC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M05 compound treatment 241640.0 -8140.0 -0.22 239720.0 -10200.0 -0.26 -0.3376 -0.9959 1149 SPBio_000243 CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M06 compound treatment 18120.0 -232000.0 -6.18 19600.0 -230000.0 -5.86 -8.5093 -0.9996 1011303 SPBio_000244 CN1CCc2cccc-3c2C1Cc4ccc(O)c(O)c43 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M07 compound treatment 133840.0 -116000.0 -3.09 115320.0 -135000.0 -3.42 -4.6066 -0.9987 3173471 SPBio_000245 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M08 compound treatment 252080.0 2300.0 0.06 251120.0 1160.0 0.03 0.0642 0.9437 980 SPBio_000246 C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)[C@@]3(O)C(=C2C(=O)c4c(O)cccc14)O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M09 compound treatment 233240.0 -16500.0 -0.44 237080.0 -12900.0 -0.33 -0.5434 -0.9893 430 SPBio_000247 NC(=O)NO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M10 compound treatment 164520.0 -85300.0 -2.27 169240.0 -80700.0 -2.05 -3.0588 -0.9987 1481 SPBio_000248 Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc4ccccc14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M11 compound treatment 206400.0 -43400.0 -1.16 211760.0 -38200.0 -0.97 -1.5047 -0.9962 1295 SPBio_000249 OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M12 compound treatment 247080.0 -2700.0 -0.07 235840.0 -14100.0 -0.36 -0.3048 -0.8324 3045196 SPBio_000250 CC1(C)S[C@@H]2[C@H](NC(=O)[C@@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M13 compound treatment 17960.0 -232000.0 -6.18 21240.0 -229000.0 -5.82 -8.4828 -0.9995 892 SPBio_000251 C[n+]1c2cc(N)ccc2cc3ccc(N)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M14 compound treatment 16640.0 -233000.0 -6.22 18320.0 -232000.0 -5.89 -8.5602 -0.9996 1309 SPBio_000252 Cc1cc(C2CCCCC2)n(O)c(=O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M15 compound treatment 230280.0 -19500.0 -0.52 232800.0 -17200.0 -0.44 -0.6762 -0.9962 1437 SPBio_000253 CS(=O)(=O)OCCCCOS(=O)(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M16 compound treatment 203120.0 -46700.0 -1.24 212320.0 -37600.0 -0.96 -1.5565 -0.9916 1110 SPBio_000254 C[C@H]1CC2C3CC[C@](OC(=O)C)(C(=O)C)[C@@]3(C)CCC2[C@@]4(C)CCC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M17 compound treatment 105880.0 -144000.0 -3.84 122800.0 -127000.0 -3.23 -4.9993 -0.9964 1198 SPBio_000255 Cn1cnc([N+](=O)[O-])c1Sc2[nH]cnc3ncnc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M18 compound treatment 15920.0 -234000.0 -6.24 16960.0 -233000.0 -5.92 -8.5982 -0.9997 1138 SPBio_000256 CC/C(=C(/CC)\c1ccc(O)cc1)/c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M19 compound treatment 240160.0 -9620.0 -0.26 240360.0 -9600.0 -0.24 -0.354 -0.9997 3174477 SPBio_000257 CN[C@H](CC(C)C)C(=O)NC1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6CC(=O)C(NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@@H](NC6=O)C(=O)O)c3O[C@@H]9OC(CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M20 compound treatment 197280.0 -52500.0 -1.4 206560.0 -43400.0 -1.1 -1.7701 -0.9931 982 SPBio_000258 CC(=O)Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M21 compound treatment 20560.0 -229000.0 -6.11 21600.0 -228000.0 -5.81 -8.4273 -0.9997 707 SPBio_000259 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CCC6C5CC[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M22 compound treatment 13720.0 -236000.0 -6.29 14040.0 -236000.0 -6.0 -8.6922 -0.9997 2114344 SPBio_000260 CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M23 mock treatment 247200.0 -2580.0 -0.07 222440.0 -27500.0 -0.7 -0.5435 -0.7729 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 M24 mock treatment 222880.0 -26900.0 -0.72 221160.0 -28800.0 -0.73 -1.025 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N01 mock treatment 262120.0 12300.0 0.33 237880.0 -12100.0 -0.31 0.0154 0.0343 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N02 mock treatment 227800.0 -22000.0 -0.59 236360.0 -13600.0 -0.35 -0.659 -0.9683 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N03 compound treatment 225080.0 -24700.0 -0.66 225640.0 -24300.0 -0.62 -0.903 -0.9995 970 SPBio_000261 CC1(C)O[C@]2(C)CC[C@H]1CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N04 compound treatment 193960.0 -55800.0 -1.49 208280.0 -41700.0 -1.06 -1.8018 -0.9862 2060424 SPBio_000262 C[C@@]12CC[C@@H](O)C[C@H]2CCc3ccccc31 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N05 compound treatment 244800.0 -4980.0 -0.13 227400.0 -22600.0 -0.57 -0.4995 -0.8484 893 SPBio_000263 NCC(O)c1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N06 compound treatment 148880.0 -101000.0 -2.69 186600.0 -63400.0 -1.61 -3.0415 -0.9699 2060300 SPBio_000264 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O)c(c4cc(ccc4OC)c5cc(=O)c6c(O)cc(O)cc6o5)c3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N07 compound treatment 223360.0 -26400.0 -0.7 223360.0 -26600.0 -0.68 -0.9764 -0.9998 2060025 SPBio_000265 CC(=O)O[C@H]1C[C@@]2(C)[C@@H](OC(=O)[C@H]3O[C@]32[C@]4(C)[C@@H](CC5C(C)(C)[C@@H](C[C@H](OC(=O)C)[C@]5(C)C14)OC(=O)C)OC(=O)C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N08 compound treatment 226880.0 -22900.0 -0.61 221320.0 -28600.0 -0.73 -0.9467 -0.9962 1010471 SPBio_000266 O=c1ccc2ccccc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N09 compound treatment 219160.0 -30600.0 -0.82 222800.0 -27200.0 -0.69 -1.0656 -0.9965 3173997 SPBio_000267 COC(=O)CC1C(C)(C)C(=O)C=CC1(C)C2CC[C@@]3(C)[C@@H](OC(=O)C4OC43C2=C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N10 compound treatment 14720.0 -235000.0 -6.27 14600.0 -235000.0 -5.98 -8.6633 -0.9997 2060107 SPBio_000268 COC1=C(OC)C(=O)C(=CC1=O)[C@H](C=C)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N11 compound treatment 15560.0 -234000.0 -6.24 16560.0 -233000.0 -5.93 -8.6122 -0.9997 3054122 SPBio_000269 CC(=O)O[C@@H]1C[C@@]2(C)[C@@H](C[C@H]3O[C@]32[C@@]4(C)C1[C@@]5(C)C=CC(=O)C(C)(C)C5=C(O)C4=O)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N12 compound treatment 230400.0 -19400.0 -0.52 242440.0 -7520.0 -0.19 -0.5006 -0.9086 2060113 SPBio_000270 Cc1cc(O)cc(O)c1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N13 compound treatment 252680.0 2900.0 0.08 247760.0 -2200.0 -0.06 0.0151 0.158 2060028 SPBio_000271 COC(=O)C[C@H]1C2(C)CC3(OC4(C)O[C@@]56[C@H](OC(=O)C)[C@@]3(O)C2OC(=O)C(C)C)[C@]1(C)[C@@]6(O4)[C@H](OC(=O)C)C(OC(=O)C)[C@@]7(C)[C@@H](OC(=O)/C(=C(\O)/C(C)C)/C57)c8ccoc8 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N14 compound treatment 240480.0 -9300.0 -0.25 240560.0 -9400.0 -0.24 -0.3444 -0.9998 2060136 SPBio_000272 CC(=C)c1cc2cc(C(=O)C)c(O)cc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N15 compound treatment 231160.0 -18600.0 -0.5 234960.0 -15000.0 -0.38 -0.6208 -0.9915 2060030 SPBio_000273 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3C(CC[C@@]4(C)[C@@H](OC(=O)C=C34)c5ccoc5)[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N16 compound treatment 61360.0 -188000.0 -5.02 82400.0 -168000.0 -4.26 -6.565 -0.9966 1049466 SPBio_000274 COc1cc(C)c2C(=O)Oc3c(C)c(O)c4C(=O)OC(O)c4c3Oc2c1C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N17 compound treatment 15080.0 -235000.0 -6.26 15920.0 -234000.0 -5.95 -8.6328 -0.9997 2060031 SPBio_000275 C[C@]12CCC3[C@@]4(C)C=CC(=O)C(C)(C)C4=C(O)C(=O)[C@@]3(C)[C@]25O[C@@H]5C[C@H]1c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N18 compound treatment 225880.0 -23900.0 -0.64 220560.0 -29400.0 -0.75 -0.9792 -0.9968 1086162 SPBio_000276 COc1c2ccoc2c(OC)c3oc(=O)ccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N19 compound treatment 190200.0 -59600.0 -1.59 172520.0 -77400.0 -1.97 -2.5156 -0.9943 2060035 SPBio_000277 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)[C@@]2(C)C=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N20 compound treatment 184440.0 -65300.0 -1.74 198400.0 -51600.0 -1.31 -2.1589 -0.9902 3077178 SPBio_000278 CC1CCC2(C)C(CCC=C2C)C1(C)CC/C(=C/Cn3c[n+](C)c4c(N)ncnc34)/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N21 compound treatment 237480.0 -12300.0 -0.33 229320.0 -20600.0 -0.52 -0.603 -0.9744 2060230 SPBio_000279 CC(=O)O[C@H]1C[C@@H](O)C(C)(C)C2C[C@@H](OC(=O)C)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N22 compound treatment 143840.0 -106000.0 -2.82 194640.0 -55300.0 -1.41 -2.992 -0.9482 2069254 SPBio_000280 CCCCCc1c(C(=O)O)c(O)cc2OC(=O)c3c(cc(OC)cc3Oc12)C(=O)CCCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N23 mock treatment 233560.0 -16200.0 -0.43 216320.0 -33600.0 -0.86 -0.9107 -0.9501 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 N24 mock treatment 242520.0 -7260.0 -0.19 229240.0 -20700.0 -0.53 -0.5094 -0.9076 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O01 mock treatment 277440.0 27700.0 0.74 238880.0 -11100.0 -0.28 0.3222 0.4082 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O02 mock treatment 242400.0 -7380.0 -0.2 290320.0 40400.0 1.03 0.5865 0.5613 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O03 compound treatment 223040.0 -26700.0 -0.71 330200.0 80200.0 2.04 0.9385 0.4342 3173595 SPBio_000281 C[C@H]1OC(OC/2CC3O[C@@](O)(CC(O)C3C(=O)O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)C(C)[C@H](O)[C@@H](C)/C=C/C=C/CC\C=C\C=C\C=C\C=C2)[C@@H](O)[C@@H](N)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O04 compound treatment 355640.0 106000.0 2.82 224760.0 -25200.0 -0.64 1.5427 0.533 1002775 SPBio_000282 Cc1cccc(C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O05 compound treatment 45080.0 -205000.0 -5.46 33640.0 -216000.0 -5.5 -7.7486 -1.0 1000036 SPBio_000283 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3C2C[C@@H]1CC4NCCc5cc(OC)c(OC)cc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O06 compound treatment 233120.0 -16700.0 -0.44 229040.0 -20900.0 -0.53 -0.6903 -0.996 3058740 SPBio_000284 CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CCC3C4CCC(=O)[C@@]4(C)CCC32)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O07 compound treatment 32880.0 -217000.0 -5.78 24560.0 -225000.0 -5.73 -8.1418 -1.0 1383 SPBio_000285 CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2OC3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O08 compound treatment 14080.0 -236000.0 -6.28 13200.0 -237000.0 -6.02 -8.7005 -0.9998 943 SPBio_000286 CCCCC1C(=O)N(N(C1=O)c2ccc(O)cc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O09 compound treatment 97800.0 -152000.0 -4.05 67280.0 -183000.0 -4.64 -6.1498 -0.9977 1260 SPBio_000287 N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O10 compound treatment 242680.0 -7100.0 -0.19 252640.0 2680.0 0.07 -0.0857 -0.426 1282 SPBio_000288 NS(=O)(=O)c1cc2c(N=CNS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O11 compound treatment 146480.0 -103000.0 -2.75 143120.0 -107000.0 -2.72 -3.8685 -1.0 1352 SPBio_000289 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O12 compound treatment 258000.0 8220.0 0.22 239600.0 -10400.0 -0.26 -0.0313 -0.0914 1020 SPBio_000290 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O13 compound treatment 244800.0 -4980.0 -0.13 284600.0 34600.0 0.88 0.5289 0.5938 720 SPBio_000291 Fc1c[nH]c(=O)[nH]c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O14 compound treatment 256520.0 6740.0 0.18 286840.0 36900.0 0.94 0.7901 0.8275 2069230 SPBio_000292 CN(C)CC[C@H](c1ccc(Cl)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O15 compound treatment 221400.0 -28400.0 -0.76 225040.0 -24900.0 -0.63 -0.9831 -0.9961 1154 SPBio_000293 O=C1CC2OCC=C3CN4CC[C@]56C4C[C@@H]3[C@@H]2C6N1c7ccccc75 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O16 compound treatment 221160.0 -28600.0 -0.76 237000.0 -13000.0 -0.33 -0.7726 -0.9295 877 SPBio_000294 CC(C)(Oc1ccc(Cl)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O17 compound treatment 233200.0 -16600.0 -0.44 238640.0 -11300.0 -0.29 -0.5162 -0.9784 3177389 SPBio_000295 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O18 compound treatment 216200.0 -33600.0 -0.9 211800.0 -38200.0 -0.97 -1.3192 -0.9992 907 SPBio_000296 OC(=O)c1cc(O)c2cccc(O)c2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O19 compound treatment 32000.0 -218000.0 -5.81 16240.0 -234000.0 -5.94 -8.308 -0.9999 1288 SPBio_000297 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O)[C@H](C)O2)N(C)C)c3c(O)c4C(=O)c5c(O)cccc5C(=O)c4cc3[C@H]1C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O20 compound treatment 137000.0 -113000.0 -3.01 120880.0 -129000.0 -3.28 -4.4471 -0.999 1006 SPBio_000298 Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O21 compound treatment 273160.0 23400.0 0.62 271280.0 21300.0 0.54 0.8241 0.9976 3174227 SPBio_000299 CC[C@@H]1[C@@H](O)N2[C@H]3C[C@@]45C(O)C3[C@@H]1CC2[C@@H]5N(C)c6ccccc64 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O22 compound treatment 230760.0 -19000.0 -0.51 227080.0 -22900.0 -0.58 -0.77 -0.9977 3077148 SPBio_000300 CCCCC(=O)Oc1ccccc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O23 mock treatment 276200.0 26400.0 0.7 266320.0 16400.0 0.42 0.7922 0.9684 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 O24 mock treatment 229800.0 -20000.0 -0.53 212120.0 -37800.0 -0.96 -1.0571 -0.9611 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P01 mock treatment 243640.0 -6140.0 -0.16 238720.0 -11200.0 -0.29 -0.3179 -0.9651 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P02 mock treatment 256600.0 6820.0 0.18 249520.0 -441.0 -0.01 0.1206 0.6623 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P03 compound treatment 197640.0 -52100.0 -1.39 187400.0 -62600.0 -1.59 -2.1078 -0.9977 2060147 SPBio_000301 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P04 compound treatment 235960.0 -13800.0 -0.37 226760.0 -23200.0 -0.59 -0.6777 -0.9743 2060138 SPBio_000302 C[C@]1([C@H]2[C@H](C(=O)O)[C@]3(CC(=C)[C@@]4(O)C3)[C@@H](CC4)[C@]52OC1=O)[C@@H](O)C=C5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P05 compound treatment 206480.0 -43300.0 -1.15 206600.0 -43400.0 -1.1 -1.596 -0.9997 2060038 SPBio_000303 COC(=O)C[C@H]1C(C)(C)C(=O)C=C[C@]1(C)C2CC[C@@]3(C)[C@@H](OC(=O)C=C3C2=C)c4ccoc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P06 compound treatment 223960.0 -25800.0 -0.69 216000.0 -34000.0 -0.86 -1.0974 -0.9937 1098 SPBio_000304 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P07 compound treatment 217440.0 -32300.0 -0.86 195440.0 -54500.0 -1.39 -1.59 -0.9739 2060055 SPBio_000305 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P08 compound treatment 302480.0 52700.0 1.41 219680.0 -30300.0 -0.77 0.4491 0.2803 2060140 SPBio_000306 COc1cc2occc2c3oc(=O)ccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P09 compound treatment 93360.0 -156000.0 -4.17 69120.0 -181000.0 -4.6 -6.2004 -0.9988 1609 SPBio_000307 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P10 compound treatment 10600.0 -239000.0 -6.38 9920.0 -240000.0 -6.1 -8.8251 -0.9998 2060142 SPBio_000308 CC(=O)OC1C/C(=C/CC/C(=C/CC[C@](C)(O)C2CC1C(=C)C(=O)O2)/C)/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P11 compound treatment 193520.0 -56300.0 -1.5 176240.0 -73700.0 -1.87 -2.3862 -0.9939 2060059 SPBio_000309 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](C[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P12 compound treatment 272720.0 22900.0 0.61 258680.0 8720.0 0.22 0.5892 0.9058 3059434 SPBio_000310 C[C@]12CC[C@@H]3[C@H](CC3(C)C)C(=O)CC[C@H]2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P13 compound treatment 261120.0 11300.0 0.3 292040.0 42100.0 1.07 0.9703 0.8727 2060060 SPBio_000311 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)[C@@]2(C)C=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P14 compound treatment 262880.0 13100.0 0.35 237080.0 -12900.0 -0.33 0.0154 0.0321 2060170 SPBio_000312 CC(=O)OC1CCC2(O)CC1(C)CCC3C2CC3(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P15 compound treatment 228920.0 -20900.0 -0.56 211480.0 -38500.0 -0.98 -1.0852 -0.9642 2060062 SPBio_000313 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P16 compound treatment 217680.0 -32100.0 -0.86 187640.0 -62300.0 -1.58 -1.7257 -0.9582 2060421 SPBio_000314 C[C@](O)(CCC1C(=C)C[C@H](O)C2C(C)(C)CCCC12C)C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P17 compound treatment 202600.0 -47200.0 -1.26 206560.0 -43400.0 -1.1 -1.6698 -0.9979 2060063 SPBio_000315 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](C(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P18 compound treatment 43200.0 -207000.0 -5.51 69680.0 -180000.0 -4.58 -7.1361 -0.9958 3177379 SPBio_000316 CC(=O)O[C@H]1CC(=C)C(CC[C@](C)(O)C=C)C2(C)CCCC(C)(C)C12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P19 compound treatment 227800.0 -22000.0 -0.59 213880.0 -36100.0 -0.92 -1.0631 -0.9766 2060066 SPBio_000317 COC(=O)CC1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P20 compound treatment 35280.0 -215000.0 -5.72 188240.0 -61700.0 -1.57 -5.1537 -0.869 2060175 SPBio_000318 C[C@](O)(CCC1C(=C)CCC2[C@@](C)(CO)CCC[C@]12C)C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P21 compound treatment 257200.0 7420.0 0.2 254800.0 4840.0 0.12 0.2269 0.9739 3173867 SPBio_000319 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P22 compound treatment 221760.0 -28000.0 -0.75 242560.0 -7400.0 -0.19 -0.6614 -0.8584 2060166 SPBio_000320 CC1(C)CC2C1CCC(=C)/C(=N\O)/CCC2=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P23 mock treatment 278200.0 28400.0 0.76 267200.0 17200.0 0.44 0.8457 0.9661 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2158 P24 mock treatment 213200.0 -36600.0 -0.98 217880.0 -32100.0 -0.82 -1.2665 -0.9961 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A01 mock treatment 250720.0 2960.0 0.08 256760.0 17200.0 0.44 0.365 0.8216 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A02 mock treatment 233200.0 -14600.0 -0.39 256800.0 17200.0 0.44 0.0354 0.0604 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A03 compound treatment 86560.0 -161000.0 -4.3 81520.0 -158000.0 -4.02 -5.8807 -0.9994 1030891 SPBio_000321 Cc1cc(=O)oc2c(O)c(O)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A04 compound treatment 249400.0 1640.0 0.04 274480.0 34900.0 0.89 0.6587 0.7411 1109169 SPBio_000322 COc1ccc2c(=O)c(coc2c1)c3cc4OCOc4cc3OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A05 compound treatment 231680.0 -16100.0 -0.43 277480.0 37900.0 0.96 0.3785 0.3588 1552436 SPBio_000323 COc1ccc(cc1)c2cc(=O)c3cc(OC)ccc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A06 compound treatment 239280.0 -8480.0 -0.23 265280.0 25700.0 0.65 0.3025 0.4372 2060405 SPBio_000324 CC1(C)[C@H](CC(=O)O)[C@@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]3(O)C[C@@H](C1=O)C2=O)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A07 compound treatment 232200.0 -15600.0 -0.41 256200.0 16600.0 0.42 0.0057 0.0097 2060323 SPBio_000325 COc1ccccc1c2cc(=O)c3c(OC)cccc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A08 compound treatment 236800.0 -11000.0 -0.29 295000.0 55400.0 1.41 0.79 0.5489 2060179 SPBio_000326 COc1cccc2c1CCC3CC(=O)CC[C@@]32C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A09 compound treatment 222160.0 -25600.0 -0.68 270440.0 30900.0 0.78 0.0725 0.0697 1499608 SPBio_000327 COc1ccc2c(=O)cc(oc2c1)c3ccccc3OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A10 compound treatment 224000.0 -23800.0 -0.63 279480.0 39900.0 1.01 0.2697 0.2254 3077346 SPBio_000328 COC(=O)c1c(C)cc(OC)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A11 compound treatment 239240.0 -8520.0 -0.23 285480.0 45900.0 1.17 0.6649 0.5591 777 SPBio_000329 Oc1ccc(cc1)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A12 compound treatment 251720.0 3960.0 0.11 278040.0 38500.0 0.98 0.7664 0.7789 1009851 SPBio_000330 O=C1c2ccccc2C(=O)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A13 compound treatment 233400.0 -14400.0 -0.38 287240.0 47700.0 1.21 0.5864 0.4613 2060418 SPBio_000331 COc1ccccc1c2cc(=O)c3cccc(OC)c3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A14 compound treatment 105080.0 -143000.0 -3.8 265600.0 26000.0 0.66 -2.2219 -0.5754 2060380 SPBio_000332 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)C3(F)[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A15 compound treatment 199360.0 -48400.0 -1.29 273600.0 34000.0 0.87 -0.3006 -0.1935 2060322 SPBio_000333 COc1ccc2c(=O)c(OC)c(oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A16 compound treatment 227840.0 -19900.0 -0.53 289880.0 50300.0 1.28 0.5291 0.382 2579 SPBio_000334 OCCSCCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A17 compound treatment 237360.0 -10400.0 -0.28 278200.0 38600.0 0.98 0.4985 0.4885 3173852 SPBio_000335 COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)C(O)[C@H](O)C3O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)cc2O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A18 compound treatment 239680.0 -8080.0 -0.22 298560.0 59000.0 1.5 0.9083 0.5994 3173468 SPBio_000336 COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A19 compound treatment 233440.0 -14300.0 -0.38 272280.0 32700.0 0.83 0.3182 0.3477 3177315 SPBio_000337 CC1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)c4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A20 compound treatment 232080.0 -15700.0 -0.42 254960.0 15400.0 0.39 -0.0188 -0.0329 1445 SPBio_000338 C/C=C(/C)\C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@@H]4[C@@]2(C[C@@]5(O)[C@@H]6CN7C[C@@H](C)CC[C@H]7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]45O)O[C@@]31O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A21 compound treatment 250720.0 2960.0 0.08 253160.0 13600.0 0.35 0.3002 0.8469 976 SPBio_000339 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A22 compound treatment 248000.0 243.0 0.01 268160.0 28600.0 0.73 0.5186 0.7134 1112405 SPBio_000340 COc1cc2OCOc2cc1c3cc4cc5ccoc5cc4oc3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A23 mock treatment 247120.0 -638.0 -0.02 250080.0 10500.0 0.27 0.177 0.6608 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 A24 mock treatment 265440.0 17700.0 0.47 245520.0 5950.0 0.15 0.4404 0.8894 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B01 mock treatment 241360.0 -6400.0 -0.17 277160.0 37600.0 0.96 0.5553 0.5719 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B02 mock treatment 251560.0 3800.0 0.1 246080.0 6510.0 0.17 0.1888 0.9723 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B03 compound treatment 15760.0 -232000.0 -6.19 16400.0 -223000.0 -5.67 -8.3863 -0.9991 1011006 SPBio_000341 O=C1C=CC(=O)c2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B04 compound treatment 233680.0 -14100.0 -0.38 265920.0 26400.0 0.67 0.2084 0.2713 3172845 SPBio_000342 CCC(C)C(=O)O[C@H]1[C@H](O)C2C(CN3CC(C)CCC3[C@@]2(C)O)C4C[C@]5(O[C@@]6(O)C7C(OC(=O)C)[C@@H](OC(=O)C)C5[C@@]41O)[C@@]7(C)CCC6OC(=O)C(C)(O)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B05 compound treatment 244600.0 -3160.0 -0.08 273280.0 33700.0 0.86 0.5466 0.6346 1000322 SPBio_000343 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(=O)O)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B06 compound treatment 216520.0 -31200.0 -0.83 251760.0 12200.0 0.31 -0.3697 -0.416 2060143 SPBio_000344 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B07 compound treatment 228400.0 -19400.0 -0.52 249320.0 9750.0 0.25 -0.1896 -0.3312 1001496 SPBio_000345 NC(=O)N1c2ccccc2CC(=O)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B08 compound treatment 234400.0 -13400.0 -0.36 262240.0 22700.0 0.58 0.1558 0.2299 1046 SPBio_000346 CC1C2C(CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC(=O)[C@]23C)OC61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B09 compound treatment 205560.0 -42200.0 -1.13 267880.0 28300.0 0.72 -0.2865 -0.2145 3198312 SPBio_000347 C[C@@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C2CC[C@]51CCC(=O)O5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B10 compound treatment 229600.0 -18200.0 -0.48 251520.0 12000.0 0.3 -0.1274 -0.223 2060339 SPBio_000348 COc1cc2N3C4[C@H]5[C@H]6C[C@@H]7N(CC[C@@]74c2cc1OC)CC6=CCOC5CC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B11 compound treatment 47280.0 -200000.0 -5.35 111320.0 -128000.0 -3.26 -6.0855 -0.9719 2069295 SPBio_000349 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)c5ccccc5c6nnn[nH]6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B12 compound treatment 242400.0 -5360.0 -0.14 238280.0 -1290.0 -0.03 -0.1242 -0.8472 3059432 SPBio_000350 CC(C)CCCC(C)[C@H]1CCC2C3C(CC[C@]12C)[C@@]4(C)CC[C@H](O)CC4=CC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B13 compound treatment 224280.0 -23500.0 -0.63 251360.0 11800.0 0.3 -0.2306 -0.3323 3480246 SPBio_000351 CCOC(=O)C1=C(COCCN)NC(=C(C1c2ccccc2Cl)C(=O)OC)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B14 compound treatment 243480.0 -4280.0 -0.11 254880.0 15300.0 0.39 0.1947 0.4798 2060325 SPBio_000352 COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(c34)-c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B15 compound treatment 239600.0 -8160.0 -0.22 272400.0 32800.0 0.83 0.4365 0.506 1001366 SPBio_000353 COc1c(N2CCNC(C)C2)c(F)cc3c(=O)c(cn(C4CC4)c13)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B16 compound treatment 222080.0 -25700.0 -0.68 277080.0 37500.0 0.95 0.1903 0.1621 2060251 SPBio_000354 NCC(N)C(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B17 compound treatment 192360.0 -55400.0 -1.48 269840.0 30300.0 0.77 -0.5002 -0.3003 3198313 SPBio_000355 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)C5[C@H](O)C[C@]43C)[C@@H]2[C@H]1C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B18 compound treatment 152320.0 -95400.0 -2.54 240520.0 952.0 0.02 -1.7822 -0.7003 297849 SPBio_000356 COc1ccc2c(c1)[nH]c3c(C)nccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B19 compound treatment 226400.0 -21400.0 -0.57 257800.0 18200.0 0.46 -0.0749 -0.102 1001346 SPBio_000357 OC(CC[C@@H]1[C@H](N(C1=O)c2ccc(F)cc2)c3ccc(O)cc3)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B20 compound treatment 231680.0 -16100.0 -0.43 268520.0 29000.0 0.74 0.2174 0.2552 2060051 SPBio_000358 Cc1cc(=O)c2c(O)cc(O)c(C)c2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B21 compound treatment 230520.0 -17200.0 -0.46 243520.0 3950.0 0.1 -0.2539 -0.5398 1333 SPBio_000359 CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B22 compound treatment 249840.0 2080.0 0.06 237280.0 -2290.0 -0.06 -0.0019 -0.0233 956 SPBio_000360 CCn1nc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B23 mock treatment 241520.0 -6240.0 -0.17 257320.0 17800.0 0.45 0.2016 0.419 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 B24 mock treatment 242960.0 -4800.0 -0.13 251600.0 12000.0 0.31 0.1259 0.3796 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C01 mock treatment 238400.0 -9360.0 -0.25 250120.0 10600.0 0.27 0.0133 0.0363 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C02 mock treatment 242560.0 -5200.0 -0.14 253840.0 14300.0 0.36 0.1586 0.4083 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C03 compound treatment 216880.0 -30900.0 -0.82 246120.0 6550.0 0.17 -0.4643 -0.5528 2060213 SPBio_000361 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)[C@H]6O[C@H]6C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C04 compound treatment 229720.0 -18000.0 -0.48 241120.0 1550.0 0.04 -0.3122 -0.6469 1530 SPBio_000362 COc1ccc2c3CCN=C(C)c3[nH]c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C05 compound treatment 209840.0 -37900.0 -1.01 240120.0 552.0 0.01 -0.7049 -0.6972 3173352 SPBio_000363 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C06 compound treatment 234400.0 -13400.0 -0.36 286480.0 46900.0 1.19 0.5916 0.4752 2060407 SPBio_000364 COc1ccc(/C=C/C(=O)O)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C07 compound treatment 244040.0 -3720.0 -0.1 261440.0 21900.0 0.56 0.3232 0.5721 2060232 SPBio_000365 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C08 compound treatment 245320.0 -2440.0 -0.06 281360.0 41800.0 1.06 0.7054 0.6626 2060504 SPBio_000366 Cc1cc(O)c(C)c(O)c1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C09 compound treatment 232720.0 -15000.0 -0.4 258840.0 19300.0 0.49 0.063 0.0995 2060233 SPBio_000367 COC(=O)C[C@H]1C(C)(C)[C@H](O)[C@@H]2CC3=C4CC(O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C10 compound treatment 225040.0 -22700.0 -0.61 278560.0 39000.0 0.99 0.2727 0.2348 2060400 SPBio_000368 CC(C)c1ccc2c(CCC3[C@](C)(CN)CCC[C@@]32C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C11 compound treatment 239440.0 -8320.0 -0.22 243400.0 3830.0 0.1 -0.0879 -0.3629 2060235 SPBio_000369 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)[C@@H]3O[C@@H]3[C@]2(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C5[C@]14C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C12 compound treatment 255760.0 8000.0 0.21 264560.0 25000.0 0.64 0.6002 0.8954 2060317 SPBio_000370 COc1cc(OC)c2c(OC)c(c3ccc4OCOc4c3)c(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C13 compound treatment 240400.0 -7360.0 -0.2 262360.0 22800.0 0.58 0.2711 0.4431 2060237 SPBio_000371 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)C(=O)O)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C14 compound treatment 240480.0 -7280.0 -0.19 275840.0 36300.0 0.92 0.5149 0.5464 891 SPBio_000372 CC(=O)OCC(=O)[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C15 compound treatment 238200.0 -9560.0 -0.25 259160.0 19600.0 0.5 0.1721 0.3075 2060240 SPBio_000373 CC1=C2C(O)C(=O)OC3CC4C(C)(C)C(=O)C=C[C@]4(C)C(CC1)[C@@]32C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C16 compound treatment 236840.0 -10900.0 -0.29 256760.0 17200.0 0.44 0.1033 0.1966 2060458 SPBio_000374 CC(=O)Oc1cccc(C(=O)O)c1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C17 compound treatment 223640.0 -24100.0 -0.64 268160.0 28600.0 0.73 0.0594 0.0612 2060241 SPBio_000375 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C18 compound treatment 115080.0 -133000.0 -3.54 171320.0 -68200.0 -1.74 -3.7285 -0.9463 3172856 SPBio_000376 O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4C(C32)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C19 compound treatment 234400.0 -13400.0 -0.36 237280.0 -2290.0 -0.06 -0.293 -0.8119 2060026 SPBio_000377 COC(=O)C[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C20 compound treatment 226160.0 -21600.0 -0.58 254040.0 14500.0 0.37 -0.147 -0.2151 1010689 SPBio_000378 COc1cc(CC=C)c(OC)c2OCOc21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C21 compound treatment 221720.0 -26000.0 -0.69 250960.0 11400.0 0.29 -0.2861 -0.3803 2060086 SPBio_000379 CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@@H](OC(=O)CC32OC4(C)OC53[C@H](OC(=O)C(C)C)[C@@]6(O)[C@@H](OC(=O)C7(C)OC7C)[C@@]8(C)C[C@]6(O)[C@@](C)([C@H]8CC(=O)OC)C15O4)c9ccoc9 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C22 compound treatment 230520.0 -17200.0 -0.46 253680.0 14100.0 0.36 -0.0713 -0.1222 1000142 SPBio_000380 CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C23 mock treatment 229840.0 -17900.0 -0.48 241600.0 2030.0 0.05 -0.3013 -0.627 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 C24 mock treatment 243760.0 -4000.0 -0.11 207560.0 -32000.0 -0.81 -0.6508 -0.7929 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D01 mock treatment 245800.0 -1960.0 -0.05 266280.0 26700.0 0.68 0.4434 0.6509 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D02 mock treatment 228360.0 -19400.0 -0.52 255080.0 15500.0 0.39 -0.0868 -0.1335 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D03 compound treatment 229200.0 -18600.0 -0.49 250440.0 10900.0 0.28 -0.1544 -0.2724 3078456 SPBio_000381 CC(=CCC[C@](C)(O)C1CCC(=CC1)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D04 compound treatment 219880.0 -27900.0 -0.74 265040.0 25500.0 0.65 -0.0676 -0.0686 2060067 SPBio_000382 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D05 compound treatment 237160.0 -10600.0 -0.28 263080.0 23500.0 0.6 0.2229 0.3371 1002856 SPBio_000383 CCC(C(=O)N)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D06 compound treatment 230080.0 -17700.0 -0.47 277960.0 38400.0 0.98 0.357 0.3293 3174120 SPBio_000384 CCCCCCCCCCCC[C@@H]([C@@H](C)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D07 compound treatment 20320.0 -227000.0 -6.06 29760.0 -210000.0 -5.33 -8.0601 -0.998 3078457 SPBio_000385 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D08 compound treatment 253520.0 5760.0 0.15 257160.0 17600.0 0.45 0.4249 0.8985 1000219 SPBio_000386 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D09 compound treatment 233040.0 -14700.0 -0.39 256360.0 16800.0 0.43 0.0244 0.0421 2069284 SPBio_000387 COc1ccc2cc(ccc2c1)[C@H](C)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D10 compound treatment 127080.0 -121000.0 -3.22 157320.0 -82200.0 -2.09 -3.7539 -0.9782 3177312 SPBio_000388 CC(C)CCCC(C)C1CCC2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D11 compound treatment 259440.0 11700.0 0.31 251920.0 12400.0 0.31 0.4423 1.0 1377 SPBio_000389 CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D12 compound treatment 245280.0 -2480.0 -0.07 278080.0 38500.0 0.98 0.6457 0.6579 1064620 SPBio_000390 COC1=CC23CCCN3CCc4cc5OCOc5cc4C2C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D13 compound treatment 256800.0 9040.0 0.24 248040.0 8470.0 0.22 0.3228 0.9984 1079 SPBio_000391 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D14 compound treatment 229960.0 -17800.0 -0.47 252000.0 12400.0 0.32 -0.112 -0.1965 1000141 SPBio_000392 OC[C@H]1O[C@@H](Oc2cc3ccc(=O)oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D15 compound treatment 227000.0 -20800.0 -0.55 258080.0 18500.0 0.47 -0.0585 -0.0805 2060414 SPBio_000393 OC(=O)c1nc2cc(Cl)c(Cl)cc2nc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D16 compound treatment 170440.0 -77300.0 -2.06 246360.0 6790.0 0.17 -1.3356 -0.6456 2060229 SPBio_000394 Oc1cc(OC(=O)c2cc(O)c(O)c(O)c2)c3C[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)[C@H](Oc3c1)c5cc(O)c(O)c(O)c5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D17 compound treatment 234000.0 -13800.0 -0.37 261280.0 21700.0 0.55 0.131 0.1976 1000393 SPBio_000395 CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D18 compound treatment 229320.0 -18400.0 -0.49 247640.0 8070.0 0.21 -0.2025 -0.3801 2060137 SPBio_000396 COc1ccc(cc1)c2coc3c(OC)c(OC)cc(OC)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D19 compound treatment 231040.0 -16700.0 -0.45 258080.0 18500.0 0.47 0.0177 0.0272 3055414 SPBio_000397 OC[C@@H]1CCCN2CCCC[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D20 compound treatment 218880.0 -28900.0 -0.77 267080.0 27500.0 0.7 -0.0498 -0.0479 2060196 SPBio_000398 COc1cc2OCC3Oc4cc5OC(C)(C)C=Cc5c(O)c4C(=O)C3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D21 compound treatment 224120.0 -23600.0 -0.63 249000.0 9430.0 0.24 -0.2761 -0.4094 2060489 SPBio_000399 C/C=C(/C)\C(=O)O[C@@H]1Cc2c(OC1(C)C)ccc3ccc(=O)oc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D22 compound treatment 194720.0 -53000.0 -1.41 210520.0 -29000.0 -0.74 -1.5222 -0.9541 3078459 SPBio_000400 CCN(CCCc1ccccc1)CCCc2ccccc2.CC(CC(=O)O)(CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D23 mock treatment 223520.0 -24200.0 -0.65 245520.0 5950.0 0.15 -0.3499 -0.5272 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 D24 mock treatment 241120.0 -6640.0 -0.18 160040.0 -79500.0 -2.02 -1.555 -0.7661 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E01 mock treatment 230320.0 -17400.0 -0.46 269080.0 29500.0 0.75 0.2019 0.2287 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E02 mock treatment 239600.0 -8160.0 -0.22 386560.0 147000.0 3.74 2.489 0.6648 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E03 compound treatment 245120.0 -2640.0 -0.07 262800.0 23200.0 0.59 0.368 0.6186 2060027 SPBio_000401 CC(=O)O[C@@H]1CC2C(C)(C)[C@@H](O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E04 compound treatment 223600.0 -24200.0 -0.64 236120.0 -3450.0 -0.09 -0.5174 -0.796 2060441 SPBio_000402 OC(=O)c1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E05 compound treatment 221120.0 -26600.0 -0.71 236880.0 -2690.0 -0.07 -0.5505 -0.7716 2060029 SPBio_000403 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E06 compound treatment 247920.0 163.0 0.0 253760.0 14200.0 0.36 0.2582 0.7155 2060452 SPBio_000404 CC1(C)O[C@@H]2C[C@](O)(C[C@@H](O)[C@@H]2O1)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E07 compound treatment 273320.0 25600.0 0.68 258320.0 18800.0 0.48 0.8191 0.9847 3173368 SPBio_000405 O=C1CC[C@]2(/C=C/C(=O)NCCCCNCCCNC(=O)\C=C\c3ccc4O[C@@H]2C1)c4c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E08 compound treatment 243600.0 -4160.0 -0.11 272800.0 33200.0 0.84 0.5191 0.6091 2060411 SPBio_000406 O[C@H]1Cc2ccc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E09 compound treatment 251440.0 3680.0 0.1 244520.0 4950.0 0.13 0.1585 0.9924 2060039 SPBio_000407 CC(=CCc1c(O)cc2oc(C)cc(=O)c2c1O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E10 compound treatment 21760.0 -226000.0 -6.03 26080.0 -213000.0 -5.43 -8.0992 -0.9986 2060392 SPBio_000408 CCOc1ccc(cc1)C(=O)c2ccc(O)c(O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E11 compound treatment 241360.0 -6400.0 -0.17 283240.0 43700.0 1.11 0.6646 0.5915 2060056 SPBio_000409 COc1cc(O)c2c(=O)cc(C)oc2c1CC=C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E12 compound treatment 259240.0 11500.0 0.31 284360.0 44800.0 1.14 1.0218 0.8664 2069228 SPBio_000410 COc1ccc2oc3ccccc3c(=O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E13 compound treatment 303360.0 55600.0 1.48 309800.0 70200.0 1.79 2.311 0.9957 2060061 SPBio_000411 Cc1cc(=O)c2c(O)c3CCC(C)(C)Oc3cc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E14 compound treatment 251560.0 3800.0 0.1 252560.0 13000.0 0.33 0.3053 0.8835 1050711 SPBio_000412 COc1cc(OC)cc(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E15 compound treatment 267600.0 19800.0 0.53 252640.0 13100.0 0.33 0.6091 0.9749 3058621 SPBio_000413 C[C@H]1C2[C@H](C[C@H]3C4CC=C5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CN6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E16 compound treatment 190960.0 -56800.0 -1.51 222800.0 -16800.0 -0.43 -1.3723 -0.8723 973 SPBio_000414 COc1ccc(cc1)C2C(=O)c3ccccc3C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E17 compound treatment 245440.0 -2320.0 -0.06 256880.0 17300.0 0.44 0.2676 0.6019 2060161 SPBio_000415 CC(=C)[C@H]1COc2cc3oc(=O)ccc3cc2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E18 compound treatment 177880.0 -69900.0 -1.86 236840.0 -2730.0 -0.07 -1.3665 -0.7329 360 SPBio_000416 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E19 compound treatment 249920.0 2160.0 0.06 256560.0 17000.0 0.43 0.3463 0.7944 1352641 SPBio_000417 COc1c2ccoc2nc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E20 compound treatment 240080.0 -7680.0 -0.2 267560.0 28000.0 0.71 0.3585 0.4841 2060502 SPBio_000418 COc1cc(cc(OC)c1O)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E21 compound treatment 377200.0 129000.0 3.45 271320.0 31800.0 0.81 3.0113 0.8496 2060295 SPBio_000419 CC(C)C1COc2cc3oc(=O)ccc3cc2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E22 compound treatment 19960.0 -228000.0 -6.07 18320.0 -221000.0 -5.63 -8.2726 -0.9993 862 SPBio_000420 CCCCCCCCCCCCCCCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E23 mock treatment 226480.0 -21300.0 -0.57 233520.0 -6050.0 -0.15 -0.5099 -0.8675 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 E24 mock treatment 256880.0 9120.0 0.24 245520.0 5950.0 0.15 0.279 0.9739 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F01 mock treatment 262240.0 14500.0 0.39 317680.0 78100.0 1.99 1.6774 0.8291 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F02 mock treatment 255080.0 7320.0 0.2 272440.0 32900.0 0.84 0.7291 0.8494 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F03 compound treatment 258760.0 11000.0 0.29 285720.0 46200.0 1.17 1.0372 0.8575 1140 SPBio_000421 CC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F04 compound treatment 231920.0 -15800.0 -0.42 297200.0 57600.0 1.47 0.7376 0.4837 3198317 SPBio_000422 CCOC(=O)[C@H](CCc1ccccc1)N[C@H](C)C(=O)N2[C@@H](C[C@@H]3CCCC[C@@H]32)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F05 compound treatment 233600.0 -14200.0 -0.38 271280.0 31700.0 0.81 0.3032 0.3406 3173234 SPBio_000423 Cn1c(=O)[nH]c(=O)c2nc[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F06 compound treatment 109200.0 -139000.0 -3.69 129840.0 -110000.0 -2.79 -4.5851 -0.9904 653 SPBio_000424 Oc1cc2cccc(O)c(=O)c2c(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F07 compound treatment 237800.0 -9960.0 -0.27 238160.0 -1410.0 -0.04 -0.213 -0.7953 1090658 SPBio_000425 COc1cc(O)c2C(=O)c3c(O)cc(C)cc3C(=O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F08 compound treatment 289240.0 41500.0 1.11 251480.0 11900.0 0.3 0.9962 0.8688 1013195 SPBio_000426 Nc1ncnc2[nH]cnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F09 compound treatment 236880.0 -10900.0 -0.29 251400.0 11800.0 0.3 0.0077 0.0183 1043296 SPBio_000427 Cc1nccc2c3ccc(O)cc3[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F10 compound treatment 289040.0 41300.0 1.1 264560.0 25000.0 0.64 1.2276 0.9659 3177456 SPBio_000428 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F11 compound treatment 275000.0 27200.0 0.73 270400.0 30800.0 0.78 1.0679 0.9993 3480229 SPBio_000429 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F12 compound treatment 154680.0 -93100.0 -2.48 157680.0 -81900.0 -2.08 -3.2271 -0.9962 1113269 SPBio_000430 CN1Cc2c3OCOc3ccc2C4C(O)Cc5cc6OCOc6cc5C41 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F13 compound treatment 260640.0 12900.0 0.34 241280.0 1710.0 0.04 0.2737 0.7904 1001491 SPBio_000431 CCCc1nc(c(C(=O)OCc2oc(=O)oc2C)n1Cc3ccc(cc3)c4ccccc4c5nn[nH]n5)C(C)(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F14 compound treatment 160000.0 -87800.0 -2.34 163640.0 -75900.0 -1.93 -3.0196 -0.9954 1020463 SPBio_000432 Oc1cc2ccc(=O)oc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F15 compound treatment 261080.0 13300.0 0.36 279040.0 39500.0 1.0 0.9609 0.9025 1000878 SPBio_000433 OCCN1C[C@@H](O)[C@@H](O)C(O)C1CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F16 compound treatment 299960.0 52200.0 1.39 257800.0 18200.0 0.46 1.312 0.8943 3174244 SPBio_000434 N=c1[nH]c(=O)c2[nH]c(=O)c(=O)[nH]c2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F17 compound treatment 278320.0 30600.0 0.81 257240.0 17700.0 0.45 0.8939 0.9606 1001030 SPBio_000435 Cc1onc(c1c2ccc(cc2)S(=O)(=O)N)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F18 compound treatment 258800.0 11000.0 0.29 255600.0 16000.0 0.41 0.4964 0.9872 1048361 SPBio_000436 c1ccc2c(c1)[nH]c3cnccc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F19 compound treatment 243240.0 -4520.0 -0.12 290600.0 51000.0 1.3 0.8323 0.6387 3198314 SPBio_000437 CCC1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(OC)C3(CCCn4cnc(c4)c5cccnc5)C[C@@H](C)C(=O)[C@H](C)[C@H]6N(C3)C(=O)O[C@@]61C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F20 compound treatment 268440.0 20700.0 0.55 281880.0 42300.0 1.08 1.1507 0.9518 2069231 SPBio_000438 CC(=CCc1cc(ccc1O)C(=O)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F21 compound treatment 257360.0 9600.0 0.26 282040.0 42500.0 1.08 0.9447 0.8512 1002855 SPBio_000439 CCC(C(=O)O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F22 compound treatment 274280.0 26500.0 0.71 265840.0 26300.0 0.67 0.9724 0.9996 819 SPBio_000440 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F23 mock treatment 241200.0 -6560.0 -0.17 247280.0 7710.0 0.2 0.015 0.0572 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 F24 mock treatment 252720.0 4960.0 0.13 201000.0 -38600.0 -0.98 -0.5999 -0.6062 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G01 mock treatment 257040.0 9280.0 0.25 251320.0 11800.0 0.3 0.3863 0.9956 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G02 mock treatment 248560.0 803.0 0.02 267880.0 28300.0 0.72 0.5242 0.7278 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G03 compound treatment 231320.0 -16400.0 -0.44 248040.0 8470.0 0.22 -0.1576 -0.3227 2060058 SPBio_000441 CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@@H](O)C(C)(C)C5CC[C@]43C)C2C1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G04 compound treatment 18760.0 -229000.0 -6.11 19440.0 -220000.0 -5.6 -8.2751 -0.9991 1057125 SPBio_000442 CC(C)(C=C)c1c2OC(C)(C)C=Cc2c(O)c3c(=O)c4ccc(O)c(O)c4oc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G05 compound treatment 245240.0 -2520.0 -0.07 262480.0 22900.0 0.58 0.3645 0.6215 3173478 SPBio_000443 C[C@H]1C(=O)CCC2[C@]1(C)CCC3[C@@]2(C)CC[C@@]4(C)C5CC(C)(C)CC[C@]5(C)CC[C@]34C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G06 compound treatment 227040.0 -20700.0 -0.55 241320.0 1750.0 0.04 -0.3591 -0.648 3173115 SPBio_000444 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@]61CCC(C)CN6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G07 compound treatment 232680.0 -15100.0 -0.4 250960.0 11400.0 0.29 -0.0794 -0.1603 3054135 SPBio_000445 CC(=O)O[C@H]1CC[C@@]2(C)C(CC[C@]3(C)C2CC=C4C5CC(C)(C)CC[C@]5(C)CC[C@]43C)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G08 compound treatment 34600.0 -213000.0 -5.68 37280.0 -202000.0 -5.14 -7.6557 -0.9988 2060429 SPBio_000446 COC1CC(O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)C(CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)OC(C)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G09 compound treatment 261160.0 13400.0 0.36 250800.0 11200.0 0.29 0.4546 0.9938 2060065 SPBio_000447 COC[C@@]12CN(C=O)C3[C@@H]4[C@H](OC)C2[C@]3(C5CC6(O)C(OC(=O)c7ccccc7)C5C4(OC(=O)C)C(O)C6OC)[C@H](C[C@H]1O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G10 compound treatment 271800.0 24000.0 0.64 267360.0 27800.0 0.71 0.953 0.9988 1082254 SPBio_000448 OC(=O)CCNC(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G11 compound treatment 264080.0 16300.0 0.44 273760.0 34200.0 0.87 0.9225 0.9488 2060068 SPBio_000449 COC1C(O)C(O[C@H]2CC[C@]3(C=O)C4[C@@H](C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)OC(=O)C)OC(C)C1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G12 compound treatment 105920.0 -142000.0 -3.78 99880.0 -140000.0 -3.55 -5.1856 -0.9995 1001284 SPBio_000450 CC(C)C1NC(=O)C(NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)NC5C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C6CCCC6C(=O)C(NC5=O)C(C)C)c4nc23)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCC7C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G13 compound treatment 263480.0 15700.0 0.42 275560.0 36000.0 0.92 0.9435 0.9373 3174249 SPBio_000451 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G14 compound treatment 26840.0 -221000.0 -5.89 27600.0 -212000.0 -5.39 -7.976 -0.999 2069274 SPBio_000452 CC(O)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(C)c3C(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G15 compound treatment 245200.0 -2560.0 -0.07 268720.0 29200.0 0.74 0.4759 0.6394 2060088 SPBio_000453 COc1cc2ccc(=O)oc2c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G16 compound treatment 235320.0 -12400.0 -0.33 273040.0 33500.0 0.85 0.3673 0.4021 840 SPBio_000454 CCOc1ccc2ccccc2c1NC(=O)[C@H]3[C@H]4SC(C)(C)C(N4C3=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G17 compound treatment 254640.0 6880.0 0.18 270000.0 30400.0 0.77 0.6769 0.8512 2060292 SPBio_000455 CC1(C)[C@H](O)C[C@H](O)[C@@]2(C)C1C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G18 compound treatment 229480.0 -18300.0 -0.49 259920.0 20400.0 0.52 0.0213 0.03 1041649 SPBio_000456 CC(C)c1ccc(C)c(C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G19 compound treatment 253960.0 6200.0 0.17 283840.0 44300.0 1.13 0.9129 0.8024 3472730 SPBio_000457 CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G20 compound treatment 212960.0 -34800.0 -0.93 259840.0 20300.0 0.52 -0.2916 -0.2747 1001523 SPBio_000458 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G21 compound treatment 267120.0 19400.0 0.52 270160.0 30600.0 0.78 0.9151 0.9802 3054130 SPBio_000459 CC(CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=C(CC[C@@]12C)C4(C)CC[C@H](OC(=O)C)C(C)(C)C4CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G22 compound treatment 218200.0 -29600.0 -0.79 227080.0 -12500.0 -0.32 -0.7818 -0.9201 2060420 SPBio_000460 CC(=O)O[C@@H]1CC2C(C)(C)[C@@H](O)CCC2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4C13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G23 mock treatment 251400.0 3640.0 0.1 259760.0 20200.0 0.51 0.4317 0.8262 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 G24 mock treatment 248400.0 643.0 0.02 185920.0 -53600.0 -1.36 -0.9524 -0.6982 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H01 mock treatment 269520.0 21800.0 0.58 232920.0 -6650.0 -0.17 0.2908 0.4811 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H02 mock treatment 252760.0 5000.0 0.13 247000.0 7430.0 0.19 0.2279 0.9855 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H03 compound treatment 240240.0 -7520.0 -0.2 262200.0 22600.0 0.58 0.2652 0.4352 1235 SPBio_000461 CCOC(=O)CCCCCCCCCCCCC1CCC=C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H04 compound treatment 121680.0 -126000.0 -3.36 123160.0 -116000.0 -2.96 -4.4699 -0.998 2565 SPBio_000462 COC1=CC(=O)OC1(O)C(=C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H05 compound treatment 245040.0 -2720.0 -0.07 266840.0 27300.0 0.69 0.4391 0.6298 1384 SPBio_000463 COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H06 compound treatment 269400.0 21600.0 0.58 248200.0 8630.0 0.22 0.5632 0.9123 2060149 SPBio_000464 Cc1cc(O)c2C(=O)c3c(O)cccc3Cc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H07 compound treatment 257840.0 10100.0 0.27 255160.0 15600.0 0.4 0.4704 0.9821 1044852 SPBio_000465 OC(=O)c1cc2cc(Cl)ccc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H08 compound treatment 259640.0 11900.0 0.32 256080.0 16500.0 0.42 0.5209 0.9904 715 SPBio_000466 COc1c2ccoc2c(OC)c3oc(C)cc(=O)c13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H09 compound treatment 26400.0 -221000.0 -5.9 24040.0 -216000.0 -5.48 -8.0484 -0.9993 3078458 SPBio_000467 CCCCCC/C=C\CCCCCCCc1cccc(O)c1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H10 compound treatment 316480.0 68700.0 1.83 277360.0 37800.0 0.96 1.9751 0.9546 886 SPBio_000468 O[C@@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H11 compound treatment 306640.0 58900.0 1.57 259160.0 19600.0 0.5 1.4624 0.8879 710 SPBio_000469 CC(=O)OCC1=C(N2C(SC1)[C@H](NC(=O)CCCC(N)C(=O)O)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H12 compound treatment 316000.0 68200.0 1.82 267280.0 27700.0 0.7 1.7848 0.9147 1737132 SPBio_000470 COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c2c34)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H13 compound treatment 337480.0 89700.0 2.39 304520.0 65000.0 1.65 2.8594 0.9836 1001994 SPBio_000471 C[C@@H](N)[C@@H](O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H14 compound treatment 300160.0 52400.0 1.4 276520.0 37000.0 0.94 1.6523 0.9814 4895 SPBio_000472 C[n+]1cccc(c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H15 compound treatment 259840.0 12100.0 0.32 248880.0 9310.0 0.24 0.3952 0.9885 1004889 SPBio_000473 CC(=O)Nc1cccc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H16 compound treatment 22480.0 -225000.0 -6.01 104800.0 -135000.0 -3.43 -6.6702 -0.9646 2060141 SPBio_000474 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccc(OC)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H17 compound treatment 274280.0 26500.0 0.71 265200.0 25600.0 0.65 0.9609 0.9992 954 SPBio_000475 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H18 compound treatment 280600.0 32800.0 0.88 261080.0 21500.0 0.55 1.006 0.9743 1539748 SPBio_000476 COc1ccccc1c2coc3cc(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H19 compound treatment 290800.0 43000.0 1.15 283600.0 44000.0 1.12 1.6032 0.9999 906 SPBio_000477 N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H20 compound treatment 291280.0 43500.0 1.16 258680.0 19100.0 0.49 1.1642 0.9254 1010377 SPBio_000478 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H21 compound treatment 172120.0 -75600.0 -2.02 168440.0 -71100.0 -1.81 -2.7048 -0.9985 2069291 SPBio_000479 COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H22 compound treatment 287240.0 39500.0 1.05 243000.0 3430.0 0.09 0.8061 0.7631 3055310 SPBio_000480 COc1c(O)cc2C(=O)O[C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]3c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H23 mock treatment 270560.0 22800.0 0.61 254440.0 14900.0 0.38 0.6973 0.9739 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 H24 mock treatment 254280.0 6520.0 0.17 156680.0 -82900.0 -2.11 -1.3673 -0.6466 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I01 mock treatment 248080.0 323.0 0.01 237400.0 -2170.0 -0.06 -0.0329 -0.5897 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I02 mock treatment 230960.0 -16800.0 -0.45 261200.0 21600.0 0.55 0.0722 0.1018 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I03 compound treatment 31120.0 -217000.0 -5.78 31600.0 -208000.0 -5.29 -7.8234 -0.999 3173612 SPBio_000481 CC(=O)OC1CC2(O)C3CCC4CC(CC[C@]4(C)C3CC[C@]2(C)C1C5=CC(=O)OC5)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I04 compound treatment 219680.0 -28100.0 -0.75 245200.0 5630.0 0.14 -0.4281 -0.5617 2060151 SPBio_000482 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)[C@H](C[C@@H](OC(=O)C)C(C)(C)C5C[C@H](O)[C@]43C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I05 compound treatment 239960.0 -7800.0 -0.21 268720.0 29200.0 0.74 0.3771 0.4899 2060096 SPBio_000483 CC(=O)O[C@@H]1CC(=O)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I06 compound treatment 240880.0 -6880.0 -0.18 250920.0 11400.0 0.29 0.0744 0.2177 2060396 SPBio_000484 OC[C@H]1O[C@@H](Oc2ccc(C(=O)/C=C/c3ccccc3)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I07 compound treatment 252400.0 4640.0 0.12 220560.0 -19000.0 -0.48 -0.2542 -0.5096 2060098 SPBio_000485 C[C@@]12CCC3C(CC[C@H]4C[C@@H](Cl)CC[C@@]43C)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I08 compound treatment 281000.0 33200.0 0.89 260720.0 21200.0 0.54 1.007 0.9713 2060410 SPBio_000486 CC1(C)[C@H](O)CC(=O)[C@@]2(C)C1C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I09 compound treatment 264080.0 16300.0 0.44 244840.0 5270.0 0.13 0.4025 0.8839 2060114 SPBio_000487 COc1c2OCOc2cc3cc[n+](C)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I10 compound treatment 256480.0 8720.0 0.23 243680.0 4110.0 0.1 0.2384 0.9349 1503 SPBio_000488 Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I11 compound treatment 271240.0 23500.0 0.63 281720.0 42200.0 1.07 1.2006 0.9672 2060122 SPBio_000489 CC1(C)Oc2cc3oc(=O)ccc3cc2C=C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I12 compound treatment 206480.0 -41300.0 -1.1 208400.0 -31200.0 -0.79 -1.3386 -0.987 3077356 SPBio_000490 COc1cc(cc(OC)c1O)[C@H]2C3C(COC3=O)[C@H](O)c4cc5OCOc5cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I13 compound treatment 27040.0 -221000.0 -5.88 24200.0 -215000.0 -5.48 -8.0334 -0.9994 2060124 SPBio_000491 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCc3c(C(C)C)c(O)ccc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I14 compound treatment 274400.0 26600.0 0.71 258560.0 19000.0 0.48 0.8438 0.9823 1837 SPBio_000492 CS(=O)(=O)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I15 compound treatment 293680.0 45900.0 1.22 252720.0 13200.0 0.33 1.1023 0.8684 2060128 SPBio_000493 CO[C@@H]1C(OC(=O)C(C)C)[C@@]2(C)[C@@H](OC(=O)/C(=C(\OC)/C(C)C)/C2[C@@]34OC5(C)O[C@]14[C@]6(C)[C@@H](CC(=O)OC)C7(C)CC6(O5)[C@](OC)(C7OC(=O)C)[C@H]3OC)c8ccoc8 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I16 compound treatment 258520.0 10800.0 0.29 249000.0 9430.0 0.24 0.3725 0.996 750 SPBio_000494 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1OC2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I17 compound treatment 250160.0 2400.0 0.06 243280.0 3710.0 0.09 0.112 0.9822 2060146 SPBio_000495 C[C@@]12CCC(=O)C=C2CCc3ccc(O)cc31 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I18 compound treatment 95360.0 -152000.0 -4.06 99320.0 -140000.0 -3.57 -5.3947 -0.9979 1358 SPBio_000496 CN(CCCl)CCCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I19 compound treatment 244000.0 -3760.0 -0.1 262160.0 22600.0 0.57 0.3353 0.5751 2060157 SPBio_000497 CC(=O)C1CCC2C3CCC4C[C@H](O)CCC4(C)C3C[C@H](O)C12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I20 compound treatment 228080.0 -19700.0 -0.52 252760.0 13200.0 0.34 -0.1338 -0.2149 1913604 SPBio_000498 OC(=O)CCCN1C(=O)c2cccc3cccc(C1=O)c23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I21 compound treatment 228600.0 -19200.0 -0.51 263080.0 23500.0 0.6 0.0615 0.0783 2060159 SPBio_000499 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)CCC(=O)C(C)(C)C5C[C@@H](OC(=O)C)[C@]43C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I22 compound treatment 236440.0 -11300.0 -0.3 177440.0 -62100.0 -1.58 -1.3304 -0.8272 3055336 SPBio_000500 Oc1ccc2sc(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I23 mock treatment 229760.0 -18000.0 -0.48 223000.0 -16600.0 -0.42 -0.6372 -0.9979 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 I24 mock treatment 229120.0 -18600.0 -0.5 185840.0 -53700.0 -1.37 -1.3174 -0.9062 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J01 mock treatment 263640.0 15900.0 0.42 280640.0 41100.0 1.04 1.0379 0.921 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J02 mock treatment 232640.0 -15100.0 -0.4 240320.0 752.0 0.02 -0.2715 -0.6728 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J03 compound treatment 247160.0 -598.0 -0.02 273160.0 33600.0 0.85 0.5927 0.6938 3198315 SPBio_000501 COc1ccc(cc1F)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J04 compound treatment 243800.0 -3960.0 -0.11 294440.0 54900.0 1.4 0.9119 0.6518 989 SPBio_000502 NC(=N)NCCCCNC(=N)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J05 compound treatment 241280.0 -6480.0 -0.17 285120.0 45600.0 1.16 0.6969 0.5951 1439 SPBio_000503 CSCCC(N)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J06 compound treatment 118920.0 -129000.0 -3.44 144840.0 -94700.0 -2.41 -4.1321 -0.9849 2060167 SPBio_000504 COC(=O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J07 compound treatment 259440.0 11700.0 0.31 292920.0 53400.0 1.36 1.1795 0.8474 3060196 SPBio_000505 COc1c(CN2CC[C@@H]3CCCN[C@@H]3C2)c(F)cc4c(=O)c(cn(C5CC5)c14)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J08 compound treatment 249480.0 1720.0 0.05 257000.0 17400.0 0.44 0.3459 0.7762 926 SPBio_000506 Oc1cccc2C(=O)c3cccc(O)c3C(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J09 compound treatment 254720.0 6960.0 0.19 256120.0 16600.0 0.42 0.4289 0.9323 1449108 SPBio_000507 Cc1ccc2c(Cl)cc(Cl)c(O)c2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J10 compound treatment 275560.0 27800.0 0.74 273680.0 34100.0 0.87 1.1375 0.9969 3055321 SPBio_000508 CC(CCC(=O)O)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J11 compound treatment 269360.0 21600.0 0.58 276800.0 37200.0 0.95 1.0767 0.9716 913 SPBio_000509 O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J12 compound treatment 322080.0 74300.0 1.98 323680.0 84100.0 2.14 2.9135 0.9993 1055132 SPBio_000510 COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J13 compound treatment 274720.0 27000.0 0.72 272720.0 33200.0 0.84 1.1044 0.9969 3480078 SPBio_000511 CC(C)N(CCC(c1ccccc1)c2cc(C)ccc2O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J14 compound treatment 263560.0 15800.0 0.42 254840.0 15300.0 0.39 0.5725 0.9992 2069273 SPBio_000512 N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J15 compound treatment 272760.0 25000.0 0.67 254520.0 15000.0 0.38 0.7402 0.9645 2060469 SPBio_000513 C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)C)C3(C)C[C@H](O)C2C4(C)C=CC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J16 compound treatment 20560.0 -227000.0 -6.06 19680.0 -220000.0 -5.59 -8.2368 -0.9992 3177314 SPBio_000514 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CCC=C4C(=O)c3c(O)c2C=C1)[C@@](C/C=C(\C)/C(=O)O)(OC5(C)C)C(=O)O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J17 compound treatment 46400.0 -201000.0 -5.37 58560.0 -181000.0 -4.6 -7.0506 -0.9971 2069250 SPBio_000515 OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J18 compound treatment 276640.0 28900.0 0.77 280840.0 41300.0 1.05 1.2866 0.9884 1084508 SPBio_000516 COc1ccc2cc3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J19 compound treatment 253720.0 5960.0 0.16 268200.0 28600.0 0.73 0.6272 0.8417 3198316 SPBio_000517 C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(OCCO)cc(O)c4c3=O)c5ccc(OCCO)c(OCCO)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J20 compound treatment 159440.0 -88300.0 -2.35 215720.0 -23800.0 -0.61 -2.0938 -0.8611 2069242 SPBio_000518 CC(=CCc1cc(cc(CC=C(C)C)c1O)C(=O)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J21 compound treatment 28880.0 -219000.0 -5.84 144920.0 -94600.0 -2.41 -5.8283 -0.9233 702 SPBio_000519 CCCCCC(=O)O[C@@]1(CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J22 compound treatment 189560.0 -58200.0 -1.55 170280.0 -69300.0 -1.76 -2.343 -0.998 3172733 SPBio_000520 Cc1c(C(=O)O)c(O)cc2C(=O)c3c(O)c(O)c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(O)c3C(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J23 mock treatment 249520.0 1760.0 0.05 266960.0 27400.0 0.7 0.5257 0.7531 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 J24 mock treatment 246560.0 -1200.0 -0.03 217400.0 -22200.0 -0.56 -0.4211 -0.746 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K01 mock treatment 246000.0 -1760.0 -0.05 207480.0 -32100.0 -0.82 -0.6101 -0.7465 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K02 mock treatment 229640.0 -18100.0 -0.48 299400.0 59800.0 1.52 0.7342 0.46 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K03 compound treatment 283440.0 35700.0 0.95 258440.0 18900.0 0.48 1.012 0.9498 2060184 SPBio_000521 CC1CCc2c(O)c3c(=O)cc(C)oc3cc2OC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K04 compound treatment 228800.0 -19000.0 -0.51 295240.0 55700.0 1.42 0.6435 0.4281 3173993 SPBio_000522 O[C@H]1CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K05 compound treatment 275840.0 28100.0 0.75 254520.0 15000.0 0.38 0.7983 0.9506 2060185 SPBio_000523 COc1ccc2[C@@H]3COc4cc(OC)ccc4[C@@H]3Oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K06 compound treatment 65760.0 -182000.0 -4.85 52600.0 -187000.0 -4.75 -6.7928 -0.9999 2069260 SPBio_000524 CC[C@@]1(O)C[C@H](O)c2c(O)c3C(=O)c4c(O)ccc(O)c4C(=O)c3cc2[C@H]1C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K07 compound treatment 31120.0 -217000.0 -5.78 24840.0 -215000.0 -5.46 -7.945 -0.9996 2060186 SPBio_000525 CC(=O)OC1CCC2(C3CCC4(C)C(CCC54OC2=O)C6=CC(=O)OC6)C(O)(CCC35)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K08 compound treatment 256440.0 8680.0 0.23 267760.0 28200.0 0.72 0.6706 0.8902 2060406 SPBio_000526 COc1ccccc1/C=C\C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K09 compound treatment 310680.0 62900.0 1.68 247200.0 7630.0 0.19 1.3235 0.7837 2060446 SPBio_000527 CC1(C)[C@@H](O)C=C[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K10 compound treatment 246400.0 -1360.0 -0.04 283800.0 44200.0 1.12 0.7697 0.684 3174367 SPBio_000528 NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K11 compound treatment 334680.0 86900.0 2.32 241960.0 2390.0 0.06 1.6818 0.7254 2060390 SPBio_000529 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)C(OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K12 compound treatment 267400.0 19600.0 0.52 271080.0 31500.0 0.8 0.9369 0.9788 2060082 SPBio_000530 COC(=O)c1cc(OC)c(=O)c2c(OC)c(OC)ccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K13 compound treatment 335320.0 87600.0 2.33 248920.0 9350.0 0.24 1.819 0.7751 1111461 SPBio_000531 CC(=CCOc1c2occc2cc3ccc(=O)oc13)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K14 compound treatment 266640.0 18900.0 0.5 253400.0 13800.0 0.35 0.6047 0.9846 1054271 SPBio_000532 COc1ccc(cc1O)c2cc(=O)c3c(O)c(OC)c(OC)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K15 compound treatment 295680.0 47900.0 1.28 260800.0 21200.0 0.54 1.2852 0.9266 3174000 SPBio_000533 C[C@H]1[C@H]2[C@H](CC3C4CC[C@@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K16 compound treatment 124480.0 -123000.0 -3.29 125040.0 -115000.0 -2.91 -4.3833 -0.9982 1527 SPBio_000534 COc1cc2OC[C@H]3Oc4c5C[C@@H](Oc5ccc4C(=O)[C@H]3c2cc1OC)C(=C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K17 compound treatment 242840.0 -4920.0 -0.13 322080.0 82500.0 2.1 1.3908 0.6616 3173615 SPBio_000535 CCC(CCC(C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K18 compound treatment 254240.0 6480.0 0.17 273080.0 33500.0 0.85 0.7247 0.8336 1001 SPBio_000536 CN(C)CCOC(=O)COc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K19 compound treatment 263040.0 15300.0 0.41 254120.0 14600.0 0.37 0.5498 0.9988 2060206 SPBio_000537 CCC(CCC(C)C1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K20 compound treatment 241040.0 -6720.0 -0.18 272760.0 33200.0 0.84 0.4701 0.5449 1065857 SPBio_000538 NC(CNC(=O)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K21 compound treatment 271160.0 23400.0 0.62 231280.0 -8290.0 -0.21 0.2922 0.4437 2069265 SPBio_000539 C[C@@]12CCC3C(CC[C@H]4CC(=O)CC[C@@]43C)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K22 compound treatment 18760.0 -229000.0 -6.11 18240.0 -221000.0 -5.63 -8.2967 -0.9992 981 SPBio_000540 CCCCCCCCCCCCCCCC[n+]1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K23 mock treatment 230840.0 -16900.0 -0.45 269680.0 30100.0 0.77 0.2224 0.2503 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 K24 mock treatment 267920.0 20200.0 0.54 207080.0 -32500.0 -0.83 -0.204 -0.207 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L01 mock treatment 290440.0 42700.0 1.14 207520.0 -32000.0 -0.81 0.2285 0.1633 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L02 mock treatment 258720.0 11000.0 0.29 240600.0 1030.0 0.03 0.2252 0.7675 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L03 compound treatment 253720.0 5960.0 0.16 264520.0 25000.0 0.63 0.561 0.8578 1009258 SPBio_000541 O=C1NC(=O)C(=O)C(=O)N1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L04 compound treatment 277880.0 30100.0 0.8 238640.0 -928.0 -0.02 0.5512 0.686 2069264 SPBio_000542 C[C@@]12CCC3C(CC[C@H]4C[C@@H](O)CC[C@@]43C)C2CC[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L05 compound treatment 256720.0 8960.0 0.24 272920.0 33400.0 0.85 0.7686 0.8724 857 SPBio_000543 O=C(OCc1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L06 compound treatment 271760.0 24000.0 0.64 252760.0 13200.0 0.34 0.6897 0.9546 1009367 SPBio_000544 OC1=CC2=C3c4ccc(O)c(O)c4OCC3(O)CC2=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L07 compound treatment 33200.0 -215000.0 -5.72 25680.0 -214000.0 -5.44 -7.8907 -0.9997 1021 SPBio_000545 CO[C@@H]1[C@@H](O)[C@H](C)O[C@@H](O[C@H]2CC[C@@]3(C)[C@H](CCC4C3CC[C@]5(C)C(CC[C@]45O)C6=CC(=O)OC6)C2)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L08 compound treatment 318920.0 71200.0 1.9 243840.0 4270.0 0.11 1.4185 0.7464 991 SPBio_000546 CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L09 compound treatment 264480.0 16700.0 0.45 249360.0 9790.0 0.25 0.4913 0.9621 1147 SPBio_000547 COc1c2ccoc2cc3oc(=O)ccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L10 compound treatment 265280.0 17500.0 0.47 269680.0 30100.0 0.77 0.8717 0.9719 1000126 SPBio_000548 C[C@H](CCC(=O)O)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L11 compound treatment 27920.0 -220000.0 -5.86 20640.0 -219000.0 -5.57 -8.0808 -0.9997 2060361 SPBio_000549 C/C=C(/C)\C(=O)O[C@@H]1[C@H](OC(=O)C)[C@]2(CO)[C@H](O)C[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(=O)O)[C@](C)(CO)C5CC[C@]43C)C2CC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L12 compound treatment 368760.0 121000.0 3.23 243840.0 4270.0 0.11 2.3581 0.7305 2060057 SPBio_000550 COC(=O)C[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L13 compound treatment 314320.0 66600.0 1.77 242160.0 2590.0 0.07 1.3015 0.7329 2060456 SPBio_000551 C[C@@H]1CC(Cl)CC[C@H]1C(=O)OC(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L14 compound treatment 366320.0 119000.0 3.16 235520.0 -4050.0 -0.1 2.1625 0.6837 2060413 SPBio_000552 CC(C)CCCC(C)[C@H]1CCC2C3CC[C@H]4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L15 compound treatment 259360.0 11600.0 0.31 222200.0 -17400.0 -0.44 -0.0935 -0.1734 2060378 SPBio_000553 Oc1nc2cc(Cl)c(Cl)cc2nc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L16 compound treatment 321440.0 73700.0 1.96 234440.0 -5130.0 -0.13 1.297 0.6587 1011559 SPBio_000554 Cc1cc(=O)oc2cc(O)c(O)cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L17 compound treatment 263600.0 15800.0 0.42 243560.0 3990.0 0.1 0.3705 0.8527 3055475 SPBio_000555 COc1ccc(/C=C/C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L18 compound treatment 281600.0 33800.0 0.9 225400.0 -14200.0 -0.36 0.3833 0.3945 2060366 SPBio_000556 CC1(C)C=CC(=O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L19 compound treatment 273480.0 25700.0 0.69 264320.0 24800.0 0.63 0.93 0.9991 1187 SPBio_000557 C[C@@]12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CC[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L20 compound treatment 20320.0 -227000.0 -6.06 18800.0 -221000.0 -5.61 -8.2572 -0.9993 2060045 SPBio_000558 CC(=C)/C=C\1/C=CC(=O)C(=C1)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L21 compound treatment 256040.0 8280.0 0.22 254880.0 15300.0 0.39 0.4315 0.9639 1052338 SPBio_000559 COc1cc2C(C)NCCc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L22 compound treatment 253080.0 5320.0 0.14 231560.0 -8010.0 -0.2 -0.0436 -0.1758 3172727 SPBio_000560 CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L23 mock treatment 254120.0 6360.0 0.17 257880.0 18300.0 0.47 0.4492 0.9064 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 L24 mock treatment 256920.0 9160.0 0.24 219400.0 -20200.0 -0.51 -0.1899 -0.3343 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M01 mock treatment 258280.0 10500.0 0.28 199400.0 -40200.0 -1.02 -0.5238 -0.4945 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M02 mock treatment 236160.0 -11600.0 -0.31 238360.0 -1210.0 -0.03 -0.2404 -0.7735 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M03 compound treatment 251240.0 3480.0 0.09 234400.0 -5170.0 -0.13 -0.0273 -0.1694 2060155 SPBio_000561 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)[C@H](C[C@@H](OC(=O)C)C(C)(C)C5C[C@@H](O)[C@]43C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M04 compound treatment 23520.0 -224000.0 -5.98 19480.0 -220000.0 -5.6 -8.1846 -0.9995 2060215 SPBio_000562 CC1(C)C2C=C[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]2(C)C=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M05 compound treatment 65760.0 -182000.0 -4.85 33760.0 -206000.0 -5.23 -7.1315 -0.9993 1010376 SPBio_000563 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M06 compound treatment 38200.0 -210000.0 -5.59 34240.0 -205000.0 -5.22 -7.6425 -0.9994 3173759 SPBio_000564 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(OC4O[C@@H]5COC(C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M07 compound treatment 228480.0 -19300.0 -0.51 220040.0 -19500.0 -0.5 -0.7145 -0.9999 1326 SPBio_000565 CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M08 compound treatment 254200.0 6440.0 0.17 236560.0 -3010.0 -0.08 0.0674 0.3583 1015281 SPBio_000566 COc1cc(O)c(C(=O)C)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M09 compound treatment 243400.0 -4360.0 -0.12 225520.0 -14000.0 -0.36 -0.3347 -0.8911 1570 SPBio_000567 CCCC(C)C1(CC=C)C(=O)NC(=NC1=O)S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M10 compound treatment 33120.0 -215000.0 -5.72 29520.0 -210000.0 -5.34 -7.8231 -0.9994 1473 SPBio_000568 CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M11 compound treatment 216120.0 -31600.0 -0.84 197920.0 -41600.0 -1.06 -1.3453 -0.9937 2060408 SPBio_000569 COC(=O)C[C@H]1C(C)(C)[C@H](C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M12 compound treatment 267360.0 19600.0 0.52 260760.0 21200.0 0.54 0.7506 0.9999 2069338 SPBio_000570 CC(=O)O[C@@H]1Cc2c(OC(=O)C)cc(OC(=O)C)cc2O[C@@H]1c3ccc(OC(=O)C)c(OC(=O)C)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M13 compound treatment 279680.0 31900.0 0.85 264840.0 25300.0 0.64 1.0562 0.9904 1050335 SPBio_000571 COc1cc(OC)c(C=O)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M14 compound treatment 203840.0 -43900.0 -1.17 159160.0 -80400.0 -2.04 -2.2737 -0.965 1950 SPBio_000572 Oc1cc2oc(cc(=O)c2c(O)c1O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M15 compound treatment 234000.0 -13800.0 -0.37 213280.0 -26300.0 -0.67 -0.732 -0.9601 3198311 SPBio_000573 Cc1cc(O)c(C=O)c2Oc3c(C)c(C(=O)O)c(O)c(COC(=O)/C=C/C(=O)O)c3OC(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M16 compound treatment 218200.0 -29600.0 -0.79 212640.0 -26900.0 -0.68 -1.0414 -0.9975 832189 SPBio_000574 CC(=O)CC(=O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M17 compound treatment 20880.0 -227000.0 -6.05 17560.0 -222000.0 -5.64 -8.2689 -0.9994 1597 SPBio_000575 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M18 compound treatment 236880.0 -10900.0 -0.29 238440.0 -1130.0 -0.03 -0.2254 -0.7733 780 SPBio_000576 CC(C)NNC(=O)c1ccncc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M19 compound treatment 235680.0 -12100.0 -0.32 238040.0 -1530.0 -0.04 -0.2552 -0.7867 2060116 SPBio_000577 CCC(=O)OC1[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@](C)([C@@H](CC(=O)OC)C1(C)C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M20 compound treatment 229600.0 -18200.0 -0.48 235280.0 -4290.0 -0.11 -0.4194 -0.8452 3173091 SPBio_000578 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)C(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3OC4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M21 compound treatment 256080.0 8320.0 0.22 233000.0 -6570.0 -0.17 0.0388 0.1398 1071570 SPBio_000579 CCOC(=O)c1c(C)cc(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M22 compound treatment 185200.0 -62600.0 -1.67 207880.0 -31700.0 -0.81 -1.7491 -0.9443 3172862 SPBio_000580 O=c1cccc2C3CNC[C@@H](C3)Cn21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M23 mock treatment 228200.0 -19600.0 -0.52 218040.0 -21500.0 -0.55 -0.7558 -0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 M24 mock treatment 233280.0 -14500.0 -0.39 213480.0 -26100.0 -0.66 -0.742 -0.9668 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N01 mock treatment 284480.0 36700.0 0.98 205080.0 -34500.0 -0.88 0.0723 0.055 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N02 mock treatment 241160.0 -6600.0 -0.18 239040.0 -528.0 -0.01 -0.1339 -0.7589 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N03 compound treatment 236760.0 -11000.0 -0.29 218760.0 -20800.0 -0.53 -0.5815 -0.9612 3471725 SPBio_000581 CC1(C)SC2C(NC(=O)C(N=C)c3ccccc3)C(=O)N2C1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N04 compound treatment 75000.0 -173000.0 -4.61 61000.0 -179000.0 -4.54 -6.4676 -1.0 3173106 SPBio_000582 COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2c(C)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N05 compound treatment 225000.0 -22800.0 -0.61 219640.0 -19900.0 -0.51 -0.7873 -0.996 3474304 SPBio_000583 COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N06 compound treatment 221680.0 -26100.0 -0.7 225960.0 -13600.0 -0.35 -0.7363 -0.9481 2069253 SPBio_000584 CC(C)/C(=C/1\C2[C@@]34OC5(C)O[C@@]4([C@H](O)C(O)[C@@]2(C)[C@@H](OC1=O)c6ccoc6)[C@]7(C)[C@@H](CC(=O)O)C8(C)CC7(O5)[C@](O)(C8O)[C@H]3O)/O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N07 compound treatment 21720.0 -226000.0 -6.03 18240.0 -221000.0 -5.63 -8.2409 -0.9994 1001621 SPBio_000585 Oc1cc(cc(O)c1O)C(=O)Oc2cc(cc(O)c2O)C(=O)OC[C@H]3O[C@H](OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)[C@H](OC(=O)c6cc(O)c(O)c(OC(=O)c7cc(O)c(O)c(O)c7)c6)[C@@H](OC(=O)c8cc(O)c(O)c(OC(=O)c9cc(O)c(O)c(O)c9)c8)[C@@H]3OC(=O)c%10cc(O)c(O)c(OC(=O)c%11cc(O)c(O)c(O)c%11)c%10 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N08 compound treatment 225320.0 -22400.0 -0.6 235800.0 -3770.0 -0.1 -0.4908 -0.81 1101 SPBio_000586 CCCC1O[C@@H]2CC3C4CCC5=CC(=O)C=CC5(C)C4[C@@H](O)CC3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N09 compound treatment 260600.0 12800.0 0.34 249960.0 10400.0 0.26 0.429 0.9918 789 SPBio_000587 C[N+]1(C)C2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N10 compound treatment 146000.0 -102000.0 -2.71 187480.0 -52100.0 -1.32 -2.855 -0.9456 3173360 SPBio_000588 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4CCCC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N11 compound treatment 62640.0 -185000.0 -4.94 36800.0 -203000.0 -5.16 -7.1357 -0.9998 2060466 SPBio_000589 OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N12 compound treatment 216120.0 -31600.0 -0.84 214600.0 -25000.0 -0.63 -1.0454 -0.9902 2060311 SPBio_000590 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4CC(=O)CC[C@]4(C)C3C=C[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N13 compound treatment 21760.0 -226000.0 -6.03 18280.0 -221000.0 -5.63 -8.2394 -0.9994 3172984 SPBio_000591 COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(=C(O)C(=O)C=C5[C@]4(C)CC[C@@]3(C)[C@@H]2C1)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N14 compound treatment 88640.0 -159000.0 -4.24 104280.0 -135000.0 -3.44 -5.4323 -0.9946 2060399 SPBio_000592 CC(C)CCCC(C)[C@H]1CCC2C3C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N15 compound treatment 230680.0 -17100.0 -0.46 233720.0 -5850.0 -0.15 -0.4271 -0.8917 911 SPBio_000593 CCCCCC(C)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N16 compound treatment 20240.0 -228000.0 -6.07 15840.0 -224000.0 -5.69 -8.3119 -0.9995 2060079 SPBio_000594 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N17 compound treatment 232280.0 -15500.0 -0.41 213520.0 -26000.0 -0.66 -0.7601 -0.9741 1001451 SPBio_000595 Cc1cc(C)cc(OCC2CNC(=O)O2)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N18 compound treatment 263200.0 15400.0 0.41 137240.0 -102000.0 -2.6 -1.5486 -0.5879 1600 SPBio_000596 CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N19 compound treatment 223080.0 -24700.0 -0.66 227480.0 -12100.0 -0.31 -0.6826 -0.9399 1470 SPBio_000597 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N20 compound treatment 139600.0 -108000.0 -2.88 101640.0 -138000.0 -3.51 -4.519 -0.9953 2060071 SPBio_000598 CCOC(=O)c1c(C)cc(O)c(C=O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N21 compound treatment 224760.0 -23000.0 -0.61 193840.0 -45700.0 -1.16 -1.2557 -0.9553 399 SPBio_000599 Nc1nc2ccc(OC(F)(F)F)cc2s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N22 compound treatment 46600.0 -201000.0 -5.36 37760.0 -202000.0 -5.13 -7.4208 -0.9998 3172726 SPBio_000600 C[C@]12C3CCC(O3)[C@]2(C)C(=O)OC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N23 mock treatment 233920.0 -13800.0 -0.37 221800.0 -17800.0 -0.45 -0.5803 -0.9949 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 N24 mock treatment 227960.0 -19800.0 -0.53 204040.0 -35500.0 -0.9 -1.012 -0.9673 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O01 mock treatment 252560.0 4800.0 0.13 231080.0 -8490.0 -0.22 -0.0621 -0.2473 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O02 mock treatment 234680.0 -13100.0 -0.35 223960.0 -15600.0 -0.4 -0.5272 -0.9979 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O03 compound treatment 214200.0 -33600.0 -0.89 118600.0 -121000.0 -3.08 -2.8076 -0.8765 2060228 SPBio_000601 COC(=O)CC1[C@@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]53O[C@]2(O)[C@@H]([C@H]5OC(=O)C)C(OC(=O)C)C1(C)C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O04 compound treatment 257480.0 9720.0 0.26 214360.0 -25200.0 -0.64 -0.2699 -0.3904 1129781 SPBio_000602 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(OC)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O05 compound treatment 35840.0 -212000.0 -5.65 15920.0 -224000.0 -5.69 -8.0164 -1.0 2060178 SPBio_000603 CC12C[C@@H](O)C3C(CCC4CC(O)CCC43C)C2(O)CCC1C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O06 compound treatment 230880.0 -16900.0 -0.45 209000.0 -30600.0 -0.78 -0.8678 -0.9662 2060451 SPBio_000604 CC(C)(O)CC[C@@H](O)[C@](C)(O)C1CC[C@@]2(O)C3=CC(=O)C4C[C@@H](O)[C@@H](O)C[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O07 compound treatment 257440.0 9680.0 0.26 177120.0 -62400.0 -1.59 -0.9402 -0.5845 2060209 SPBio_000605 COc1cc2OCC3Oc4c(C(=O)O)c(O)ccc4C(=O)C3(O)c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O08 compound treatment 292240.0 44500.0 1.19 205960.0 -33600.0 -0.85 0.2344 0.1603 3174226 SPBio_000606 CC[N+](C)(C)Cc1ccc(Br)cc1.Cc1ccc(cc1)S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O09 compound treatment 156480.0 -91300.0 -2.43 34240.0 -205000.0 -5.22 -5.4125 -0.9396 2060130 SPBio_000607 COc1ccc(cc1)[C@@H](C)C(=O)c2ccc(O)cc2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O10 compound treatment 241360.0 -6400.0 -0.17 205200.0 -34400.0 -0.87 -0.7385 -0.8295 3263 SPBio_000608 CNC(C)(C)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O11 compound treatment 252200.0 4440.0 0.12 237240.0 -2330.0 -0.06 0.0419 0.3164 2060064 SPBio_000609 CCC(C)C(=O)OC1[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@](C)([C@@H](CC(=O)OC)C1(C)C)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O12 compound treatment 301480.0 53700.0 1.43 268720.0 29200.0 0.74 1.537 0.953 1231 SPBio_000610 CC(C)C[C@H](NC(=O)C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O13 compound treatment 239280.0 -8480.0 -0.23 218560.0 -21000.0 -0.53 -0.5375 -0.9268 2060078 SPBio_000611 COc1cc2OC[C@H]3Oc4c(CC=C(C)C)c(O)ccc4C(=O)[C@H]3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O14 compound treatment 252680.0 4920.0 0.13 250680.0 11100.0 0.28 0.2926 0.9392 2060471 SPBio_000612 C[C@H]1[C@H]2[C@H](OC1=O)[C@@H]3C(=CC(=O)C3=C(C)C[C@@H]2O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O15 compound treatment 154560.0 -93200.0 -2.48 126800.0 -113000.0 -2.87 -3.7846 -0.9975 1009294 SPBio_000613 Oc1ccc2C(=O)c3ccccc3C(=O)c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O16 compound treatment 116960.0 -131000.0 -3.49 59080.0 -180000.0 -4.59 -5.711 -0.9908 3055313 SPBio_000614 CC(C)[C@@]12O[C@H]2[C@@H]3O[C@]34[C@]5(O[C@H]5C[C@H]6C7=C(CC[C@@]64C)C(=O)OC7)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O17 compound treatment 251560.0 3800.0 0.1 209960.0 -29600.0 -0.75 -0.4606 -0.6064 1112402 SPBio_000615 COc1ccc2ccc(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O18 compound treatment 41880.0 -206000.0 -5.49 39880.0 -200000.0 -5.08 -7.4717 -0.9992 2559 SPBio_000616 CC(=O)O[Cd]OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O19 compound treatment 198240.0 -49500.0 -1.32 184600.0 -55000.0 -1.4 -1.9219 -0.9996 1016781 SPBio_000617 OC(=O)c1cc(O)c(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O20 compound treatment 257280.0 9520.0 0.25 250520.0 11000.0 0.28 0.3764 0.9989 1120 SPBio_000618 Oc1ccc(cc1[N+](=O)[O-])[As](=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O21 compound treatment 249920.0 2160.0 0.06 217480.0 -22100.0 -0.56 -0.3564 -0.6312 2060044 SPBio_000619 CC(=O)Oc1cc(cc(OC(=O)C)c1OC(=O)C)c2coc3cc(OC(=O)C)c(OC(=O)C)c(OC(=O)C)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O22 compound treatment 186120.0 -61600.0 -1.64 171840.0 -67700.0 -1.72 -2.3798 -0.9997 2060156 SPBio_000620 CCC(C)C(O)C(=O)O[C@H]1[C@H](OC=O)C(C(=C)C2(O)C(=O)C[C@@H](c3ccoc3)[C@]12C)[C@]4(C)C(CC(=O)OC)[C@@](C)(COC(=O)C)OC(=O)C[C@@H]4OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O23 mock treatment 267120.0 19400.0 0.52 245320.0 5750.0 0.15 0.4685 0.8731 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 O24 mock treatment 282920.0 35200.0 0.94 264160.0 24600.0 0.63 1.1051 0.9806 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P01 mock treatment 237760.0 -10000.0 -0.27 250320.0 10800.0 0.27 0.0048 0.0126 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P02 mock treatment 277800.0 30000.0 0.8 233760.0 -5810.0 -0.15 0.462 0.5672 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P03 compound treatment 243760.0 -4000.0 -0.11 200800.0 -38800.0 -0.99 -0.7724 -0.779 1001332 SPBio_000621 CN(C)CCC[C@]1(OCc2cc(C#N)ccc21)c3ccc(F)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P04 compound treatment 267720.0 20000.0 0.53 212360.0 -27200.0 -0.69 -0.1128 -0.1293 2060433 SPBio_000622 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O[C@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P05 compound treatment 9360.0 -238000.0 -6.36 7320.0 -232000.0 -5.91 -8.6702 -0.9993 1228 SPBio_000623 CC[Hg]Sc1ccccc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P06 compound treatment 37920.0 -210000.0 -5.59 7360.0 -232000.0 -5.9 -8.1311 -0.9996 336 SPBio_000624 COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P07 compound treatment 121880.0 -126000.0 -3.36 30960.0 -209000.0 -5.3 -6.1238 -0.9756 1210108 SPBio_000625 Oc1ccc2cccc(O)c(=O)c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P08 compound treatment 292840.0 45100.0 1.2 158400.0 -81200.0 -2.06 -0.6094 -0.2552 1043 SPBio_000626 O[Hg]c1c(O)c(Br)cc2c(c3ccccc3C(=O)O)c4cc(Br)c(=O)cc4oc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P09 compound treatment 286000.0 38200.0 1.02 195920.0 -43600.0 -1.11 -0.0638 -0.0423 932 SPBio_000627 NCCCCC(N)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCCN)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P10 compound treatment 262920.0 15200.0 0.4 155720.0 -83800.0 -2.13 -1.2217 -0.563 2060324 SPBio_000628 CC12CC[C@@H]3[C@H](CC3(C)C)C(=C)CC2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P11 compound treatment 261520.0 13800.0 0.37 233880.0 -5690.0 -0.14 0.1572 0.3986 1032444 SPBio_000629 CC(=O)Oc1c(C)cccc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P12 compound treatment 312520.0 64800.0 1.73 276120.0 36600.0 0.93 1.8782 0.9578 2060355 SPBio_000630 CC1=C(C=C)/C(=C/c2[nH]c(Cc3[nH]c(\C=C\4/NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)/NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P13 compound treatment 311280.0 63500.0 1.69 237080.0 -2490.0 -0.06 1.1529 0.6802 1578 SPBio_000631 CC1=NCCc2c1[nH]c3cc(O)ccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P14 compound treatment 282520.0 34800.0 0.93 228120.0 -11400.0 -0.29 0.4496 0.4628 3174615 SPBio_000632 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P15 compound treatment 290600.0 42800.0 1.14 225360.0 -14200.0 -0.36 0.5523 0.461 3173998 SPBio_000633 CC(=O)O[C@@H]1C2CC[C@@H]3C1(C[C@@]2(C)O)C[C@@H](O)[C@@]4(O)[C@@H](C[C@H](O)C4(C)C)[C@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P16 compound treatment 287040.0 39300.0 1.05 238880.0 -688.0 -0.02 0.7282 0.6952 3173217 SPBio_000634 CCN1C[C@@]2(COC)C3[C@@H](OC)[C@H]4[C@@H]1[C@@]3(C5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)C5[C@]4(OC(=O)C)[C@@H](O)[C@@H]6OC)C(C[C@H]2O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P17 compound treatment 306880.0 59100.0 1.58 206000.0 -33600.0 -0.85 0.5111 0.2851 2069287 SPBio_000635 CCCCCC1C(CC(=O)OC)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P18 compound treatment 203640.0 -44100.0 -1.18 122120.0 -117000.0 -2.99 -2.9434 -0.9171 425 SPBio_000636 Oc1ccc(cc1)c2coc3cc(O)cc(O)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P19 compound treatment 278360.0 30600.0 0.82 219960.0 -19600.0 -0.5 0.2244 0.2347 1229 SPBio_000637 CC(=O)N[C@H]1[C@@H](O)C[C@](O)(O[C@@H]1C(O)[C@H](O)CO)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P20 compound treatment 254160.0 6400.0 0.17 206720.0 -32800.0 -0.84 -0.4699 -0.5512 2060371 SPBio_000638 COC(=O)C[C@H]1C(C)(C)C2(O)OC34CC2C(=O)[C@]1(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C35)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P21 compound treatment 192280.0 -55500.0 -1.48 190040.0 -49500.0 -1.26 -1.9364 -0.9968 2070 SPBio_000639 COc1ccc(cc1)c2coc3cc(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P22 compound treatment 259800.0 12000.0 0.32 237080.0 -2490.0 -0.06 0.1823 0.5571 1000253 SPBio_000640 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P23 mock treatment 277360.0 29600.0 0.79 231920.0 -7650.0 -0.19 0.4206 0.5174 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2159 P24 mock treatment 233680.0 -14100.0 -0.38 203120.0 -36400.0 -0.93 -0.9207 -0.9208 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A01 mock treatment 259320.0 11300.0 0.3 256680.0 11100.0 0.28 0.414 0.9995 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A02 mock treatment 262200.0 14200.0 0.38 241800.0 -3740.0 -0.09 0.2008 0.5139 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A03 compound treatment 253840.0 5850.0 0.16 223760.0 -21800.0 -0.55 -0.2812 -0.4888 2060176 SPBio_000641 CC(=O)/C=C\[C@H]1[C@](C)(O)CCC2C(C)(C)CCC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A04 compound treatment 256560.0 8570.0 0.23 248200.0 2660.0 0.07 0.2095 0.8789 3057756 SPBio_000642 C1CCN2C[C@H]3C[C@@H](CN4CCCC[C@H]34)[C@@H]2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A05 compound treatment 246840.0 -1150.0 -0.03 129720.0 -116000.0 -2.94 -2.104 -0.7144 1016582 SPBio_000643 COc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A06 compound treatment 275800.0 27800.0 0.74 235720.0 -9820.0 -0.25 0.3478 0.4446 1151 SPBio_000644 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A07 compound treatment 238760.0 -9230.0 -0.25 211120.0 -34400.0 -0.88 -0.7928 -0.8721 3054108 SPBio_000645 Nc1nc2ncc(=O)[nH]c2c(=O)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A08 compound treatment 249680.0 1690.0 0.05 191000.0 -54500.0 -1.39 -0.9486 -0.6838 1023016 SPBio_000646 COc1ccc2ccc(=O)oc2c1CC=C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A09 compound treatment 93400.0 -155000.0 -4.12 16560.0 -229000.0 -5.82 -7.0313 -0.9857 2060374 SPBio_000647 CCC(C)C(OC(=O)C)C(=O)O[C@H]1[C@H](O)C2[C@@]3(C)C=CC(=O)C(C)(C)C3C[C@@H](OC(=O)C(O)C(C)C)[C@@]2(C)[C@]45O[C@@H]5C[C@@H](c6ccoc6)[C@]14C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A10 compound treatment 13720.0 -234000.0 -6.25 11280.0 -234000.0 -5.96 -8.6285 -0.9997 2549 SPBio_000648 C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A11 compound treatment 206520.0 -41500.0 -1.11 188800.0 -56700.0 -1.44 -1.8019 -0.9914 2069225 SPBio_000649 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c5c(=O)c(O)cc(cc45)[C@H]6Oc7cc(O)cc(O)c7C[C@H]6OC(=O)c8cc(O)c(O)c(O)c8 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A12 compound treatment 254040.0 6050.0 0.16 260320.0 14800.0 0.38 0.3799 0.9287 3059440 SPBio_000650 OC(=O)C1CC(CN2CCCCC12)[C@@H]3CCCCN3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A13 compound treatment 252440.0 4450.0 0.12 214920.0 -30600.0 -0.78 -0.4665 -0.5925 2546 SPBio_000651 COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A14 compound treatment 256280.0 8290.0 0.22 246280.0 744.0 0.02 0.1697 0.7648 2060439 SPBio_000652 COC1=C(OC)C(=O)C(=C(C)C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC\C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A15 compound treatment 263160.0 15200.0 0.4 210560.0 -35000.0 -0.89 -0.3428 -0.3509 3078460 SPBio_000653 CO/N=C(\C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)/C=C\c3scnc3C)/c4csc(N)n4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A16 compound treatment 258600.0 10600.0 0.28 233920.0 -11600.0 -0.3 -0.0088 -0.0215 1307902 SPBio_000654 CN1CCCCC1c2ccc(nc2)c3cccnc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A17 compound treatment 273760.0 25800.0 0.69 222720.0 -22800.0 -0.58 0.0757 0.0841 2575 SPBio_000655 CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A18 compound treatment 277840.0 29900.0 0.8 235840.0 -9700.0 -0.25 0.3885 0.4662 3078270 SPBio_000656 CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A19 compound treatment 215320.0 -32700.0 -0.87 177560.0 -68000.0 -1.73 -1.8381 -0.9497 3480341 SPBio_000657 CN1CCCC(CC1)n2nc(Cc3ccc(Cl)cc3)c4ccccc4c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A20 compound treatment 258320.0 10300.0 0.28 236000.0 -9540.0 -0.24 0.0233 0.0636 1204574 SPBio_000658 COc1c(oc2cc3oc(=O)ccc3cc12)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A21 compound treatment 34880.0 -213000.0 -5.68 10680.0 -235000.0 -5.97 -8.2403 -0.9997 1351 SPBio_000659 Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A22 compound treatment 97960.0 -150000.0 -4.0 73840.0 -172000.0 -4.37 -5.9155 -0.999 1008178 SPBio_000660 COc1cc(C)c(C(=O)Oc2cc(C)c(C(=O)O)c(O)c2C)c(OC)c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A23 mock treatment 261880.0 13900.0 0.37 232800.0 -12700.0 -0.32 0.0329 0.0669 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 A24 mock treatment 242800.0 -5190.0 -0.14 252240.0 6700.0 0.17 0.0227 0.1034 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B01 mock treatment 283040.0 35100.0 0.93 280480.0 34900.0 0.89 1.2891 0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B02 mock treatment 268440.0 20500.0 0.55 241800.0 -3740.0 -0.09 0.3184 0.5752 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B03 compound treatment 244720.0 -3270.0 -0.09 225120.0 -20400.0 -0.52 -0.4287 -0.8144 2069255 SPBio_000661 Oc1cc(cc(O)c1O)c2coc3cc(O)c(O)c(O)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B04 compound treatment 287920.0 39900.0 1.06 220560.0 -25000.0 -0.64 0.3038 0.245 2060101 SPBio_000662 COc1ccc(cc1OC)[C@H]2Oc3c(I)c(OC)cc(OC)c3C[C@@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B05 compound treatment 271360.0 23400.0 0.62 243600.0 -1940.0 -0.05 0.4058 0.6492 901 SPBio_000663 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B06 compound treatment 247400.0 -589.0 -0.02 209200.0 -36300.0 -0.92 -0.6644 -0.719 910 SPBio_000664 CN1CC(CNC(=O)OCc2ccccc2)C[C@@H]3C1Cc4cn(C)c5cccc3c45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B07 compound treatment 240440.0 -7550.0 -0.2 234080.0 -11500.0 -0.29 -0.3483 -0.9837 1315 SPBio_000665 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B08 compound treatment 267480.0 19500.0 0.52 226680.0 -18900.0 -0.48 0.0285 0.0402 683 SPBio_000666 Cc1ncc([N+](=O)[O-])n1CCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B09 compound treatment 68760.0 -179000.0 -4.78 162920.0 -82600.0 -2.1 -4.8644 -0.9319 2069270 SPBio_000667 CC(C)CCCC(C)C1CCC2C3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B10 compound treatment 259160.0 11200.0 0.3 236160.0 -9380.0 -0.24 0.042 0.1102 3059437 SPBio_000668 OC[C@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B11 compound treatment 270520.0 22500.0 0.6 255400.0 9860.0 0.25 0.6021 0.9249 1044412 SPBio_000669 Oc1cc2ccccc2oc1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B12 compound treatment 240360.0 -7630.0 -0.2 234200.0 -11300.0 -0.29 -0.3476 -0.9854 1090 SPBio_000670 CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B13 compound treatment 129720.0 -118000.0 -3.15 133240.0 -112000.0 -2.86 -4.2488 -0.9988 3198326 SPBio_000671 O[C@@H]1O[C@H](COC(=O)CC[N+](=O)[O-])[C@@H](OC(=O)CC[N+](=O)[O-])[C@H](OC(=O)CC[N+](=O)[O-])[C@H]1OC(=O)CC[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B14 compound treatment 83760.0 -164000.0 -4.38 83200.0 -162000.0 -4.13 -6.0149 -0.9996 1259 SPBio_000672 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B15 compound treatment 147920.0 -100000.0 -2.67 126160.0 -119000.0 -3.04 -4.0329 -0.9979 3177521 SPBio_000673 COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](OC(=O)C)c4cc5OCOc5cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B16 compound treatment 93160.0 -155000.0 -4.13 131760.0 -114000.0 -2.89 -4.9646 -0.9849 2551 SPBio_000674 COc1cc(NC(C)CCCN)c2ncccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B17 compound treatment 231080.0 -16900.0 -0.45 207480.0 -38100.0 -0.97 -1.003 -0.9396 1050602 SPBio_000675 COc1ccc(CC(=O)c2ccc(O)cc2O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B18 compound treatment 17600.0 -230000.0 -6.14 14840.0 -231000.0 -5.87 -8.4913 -0.9997 763 SPBio_000676 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B19 compound treatment 248320.0 331.0 0.01 199440.0 -46100.0 -1.17 -0.8225 -0.7018 2069259 SPBio_000677 C[C@@]12CCC3C(CC[C@H]4C[C@H](O)CC[C@@]43C)C2CC[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B20 compound treatment 18320.0 -230000.0 -6.12 13680.0 -232000.0 -5.9 -8.4986 -0.9998 368 SPBio_000678 CC/C(=C(\c1ccccc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B21 compound treatment 242320.0 -5670.0 -0.15 232760.0 -12800.0 -0.32 -0.3366 -0.9394 3172708 SPBio_000679 CCC(C)C(=O)O[C@H]1[C@H](O)C2C(CN3CC(C)CCC3[C@@]2(C)O)C4C[C@]5(O[C@@]6(O)C7C(OC(=O)C)[C@@H](OC(=O)C)C5[C@@]41O)[C@@]7(C)CCC6OC(=O)C(C)(O)C(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B22 compound treatment 125160.0 -123000.0 -3.27 121040.0 -124000.0 -3.17 -4.5541 -0.9999 3198420 SPBio_000680 CC[C@]1(O)CC2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@H]7[C@@]86CCN9CC=C[C@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B23 mock treatment 276360.0 28400.0 0.76 248760.0 3220.0 0.08 0.5929 0.7792 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 B24 mock treatment 258440.0 10500.0 0.28 236720.0 -8820.0 -0.22 0.0385 0.1077 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C01 mock treatment 254320.0 6330.0 0.17 236640.0 -8900.0 -0.23 -0.0406 -0.1438 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C02 mock treatment 246680.0 -1310.0 -0.03 230200.0 -15300.0 -0.39 -0.3004 -0.7673 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C03 compound treatment 223200.0 -24800.0 -0.66 230120.0 -15400.0 -0.39 -0.7445 -0.9689 2060254 SPBio_000681 CC(=O)CC1CCCCN1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C04 compound treatment 225360.0 -22600.0 -0.6 215720.0 -29800.0 -0.76 -0.9627 -0.9936 2060501 SPBio_000682 CC(C)(OC(=O)c1ccccc1)[C@@H]2Cc3cc4ccc(=O)oc4cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C05 compound treatment 238800.0 -9190.0 -0.24 217040.0 -28500.0 -0.72 -0.6856 -0.8963 2060245 SPBio_000683 OC[C@H]1O[C@@](CO)(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C06 compound treatment 240040.0 -7950.0 -0.21 235280.0 -10300.0 -0.26 -0.3343 -0.9947 3177461 SPBio_000684 CN1C2C[C@H](O)[C@@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C07 compound treatment 230960.0 -17000.0 -0.45 232320.0 -13200.0 -0.34 -0.5587 -0.989 2069293 SPBio_000685 CCc1ccc2c(O)c3C(=O)c4c(O)ccc(O)c4C(=O)c3cc2c1C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C08 compound treatment 224280.0 -23700.0 -0.63 224400.0 -21100.0 -0.54 -0.827 -0.9967 1296906 SPBio_000686 COc1ccc(C(=O)CC(=O)O)c2OC(C)(C)C=Cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C09 compound treatment 74000.0 -174000.0 -4.64 34560.0 -211000.0 -5.36 -7.0735 -0.9974 1092958 SPBio_000687 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C10 compound treatment 108400.0 -140000.0 -3.72 139720.0 -106000.0 -2.69 -4.5342 -0.9873 1253 SPBio_000688 C[C@H]1OC=C2C(=C(C(=O)O)C(=O)C(=C2[C@@H]1C)C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C11 compound treatment 239040.0 -8950.0 -0.24 227320.0 -18200.0 -0.46 -0.4962 -0.9524 1262 SPBio_000689 NC[C@H]1CC[C@@H](CC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C12 compound treatment 245400.0 -2590.0 -0.07 240200.0 -5340.0 -0.14 -0.1447 -0.9509 1216977 SPBio_000690 CC1(C)Oc2ccc3ccc(=O)oc3c2CC1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C13 compound treatment 249760.0 1770.0 0.05 250000.0 4460.0 0.11 0.1136 0.9245 1000143 SPBio_000691 NC(Cn1ccc(=O)c(O)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C14 compound treatment 232880.0 -15100.0 -0.4 228960.0 -16600.0 -0.42 -0.5829 -0.9997 2321 SPBio_000692 COc1ccc2CC3N(CCc4cc(OC)c(OC)cc34)Cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C15 compound treatment 256080.0 8090.0 0.22 233680.0 -11900.0 -0.3 -0.0606 -0.1635 3172716 SPBio_000693 NC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C16 compound treatment 232160.0 -15800.0 -0.42 230040.0 -15500.0 -0.39 -0.577 -0.9994 3055383 SPBio_000694 CC(C)(O)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C17 compound treatment 240760.0 -7230.0 -0.19 217120.0 -28400.0 -0.72 -0.6472 -0.8655 3078461 SPBio_000695 NCCc1ccccc1S(=O)(=O)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C18 compound treatment 215320.0 -32700.0 -0.87 226520.0 -19000.0 -0.48 -0.9578 -0.9614 1501 SPBio_000696 NCCc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C19 compound treatment 37680.0 -210000.0 -5.61 26040.0 -219000.0 -5.58 -7.9114 -1.0 3198318 SPBio_000697 C[C@H]1CCCC(=O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C20 compound treatment 250120.0 2130.0 0.06 221280.0 -24300.0 -0.62 -0.3959 -0.6392 1368 SPBio_000698 CCC(C)C(N)C1=NC(CS1)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NCCCCC2NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(Cc3c[nH]cn3)NC(=O)C(Cc4ccccc4)NC(=O)C(NC(=O)C(CCCN)NC2=O)C(C)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C21 compound treatment 231640.0 -16300.0 -0.44 209200.0 -36300.0 -0.92 -0.9615 -0.9412 2141061 SPBio_000699 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(C[C@@H](O)[C@@H](O)[C@@H](O)CO)c2cc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C22 compound treatment 224440.0 -23500.0 -0.63 218800.0 -26700.0 -0.68 -0.9247 -0.9992 2060491 SPBio_000700 CC(C)CC(=O)O[C@@H]1[C@H](OC(=O)C)c2c(OC1(C)C)ccc3ccc(=O)oc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C23 mock treatment 237840.0 -10100.0 -0.27 213760.0 -31800.0 -0.81 -0.7627 -0.8951 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 C24 mock treatment 231080.0 -16900.0 -0.45 225320.0 -20200.0 -0.51 -0.6823 -0.9979 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D01 mock treatment 244840.0 -3150.0 -0.08 239360.0 -6180.0 -0.16 -0.1704 -0.957 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D02 mock treatment 230920.0 -17100.0 -0.46 229920.0 -15600.0 -0.4 -0.6026 -0.9977 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D03 compound treatment 222280.0 -25700.0 -0.69 225960.0 -19600.0 -0.5 -0.8367 -0.9876 2060503 SPBio_000701 C1Oc2ccc(cc2O1)[C@H]3OC[C@@H]4[C@@H](OC[C@H]34)c5ccc6OCOc6c5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D04 compound treatment 15600.0 -232000.0 -6.2 15760.0 -230000.0 -5.84 -8.5125 -0.9996 1070 SPBio_000702 CCC(C(CC)c1ccc(O)cc1)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D05 compound treatment 68840.0 -179000.0 -4.78 48280.0 -197000.0 -5.02 -6.9241 -0.9997 2060397 SPBio_000703 COc1ccc2C(=O)/C(=C/c3ccc(OC)c(O)c3)/COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D06 compound treatment 104080.0 -144000.0 -3.84 107480.0 -138000.0 -3.51 -5.1953 -0.999 804 SPBio_000704 COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D07 compound treatment 240520.0 -7470.0 -0.2 237520.0 -8020.0 -0.2 -0.2849 -0.9999 2069258 SPBio_000705 COc1ccc(c(OC)c1O)c2coc3cc(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D08 compound treatment 68320.0 -180000.0 -4.79 63520.0 -182000.0 -4.63 -6.6599 -0.9999 1091345 SPBio_000706 Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D09 compound treatment 232720.0 -15300.0 -0.41 235520.0 -10000.0 -0.25 -0.468 -0.9745 1022 SPBio_000707 COc1cc(OC)c2ccc(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D10 compound treatment 229280.0 -18700.0 -0.5 157520.0 -88000.0 -2.24 -1.9352 -0.844 909 SPBio_000708 COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D11 compound treatment 252360.0 4370.0 0.12 230600.0 -14900.0 -0.38 -0.1861 -0.4685 2060379 SPBio_000709 COc1ccc(cc1)c2coc3c(OC)c(OC)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D12 compound treatment 122240.0 -126000.0 -3.35 120720.0 -125000.0 -3.17 -4.6149 -0.9996 599 SPBio_000710 Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D13 compound treatment 53360.0 -195000.0 -5.19 79440.0 -166000.0 -4.22 -6.6557 -0.9948 3173357 SPBio_000711 CC(=C)[C@@H]1CC[C@@]2(CCC3[C@H](CCC4[C@@]3(C)CCC5C(C)(C)[C@H](O)CC[C@@]54C)C12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D14 compound treatment 21560.0 -226000.0 -6.04 19080.0 -226000.0 -5.76 -8.3404 -0.9997 3173213 SPBio_000712 COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)C(O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D15 compound treatment 233960.0 -14000.0 -0.37 230440.0 -15100.0 -0.38 -0.5359 -0.9999 2069325 SPBio_000713 OC(=O)/C=C/C=C/c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D16 compound treatment 213840.0 -34100.0 -0.91 211680.0 -33900.0 -0.86 -1.2525 -0.9996 3078281 SPBio_000714 C[C@H]1OC(C(O)[C@@H]1O)n2cc(F)c(=O)[nH]c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D17 compound treatment 226960.0 -21000.0 -0.56 237200.0 -8340.0 -0.21 -0.5463 -0.9115 3173762 SPBio_000715 CC1OC(O[C@@H]/2CC3O[C@@](O)(C[C@H](O)C3C(=O)O)CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C2)C(O)[C@H](N)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D18 compound treatment 215200.0 -32800.0 -0.87 220880.0 -24700.0 -0.63 -1.0615 -0.9867 1477 SPBio_000716 O=C1O[Pt]OC(=O)C21CCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D19 compound treatment 19360.0 -229000.0 -6.1 18160.0 -227000.0 -5.78 -8.3985 -0.9996 1907763 SPBio_000717 Oc1ccc(/C=C/C(=O)OCCc2ccccc2)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D20 compound treatment 242840.0 -5150.0 -0.14 235360.0 -10200.0 -0.26 -0.28 -0.956 1475 SPBio_000718 Cl[Pt]Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D21 compound treatment 126240.0 -122000.0 -3.25 118520.0 -127000.0 -3.23 -4.579 -1.0 1913676 SPBio_000719 COc1ccc(cc1)C(=O)/C=C/c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D22 compound treatment 90800.0 -157000.0 -4.19 80800.0 -165000.0 -4.19 -5.9254 -1.0 2080598 SPBio_000720 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC2CC(=O)NC(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D23 mock treatment 234200.0 -13800.0 -0.37 229720.0 -15800.0 -0.4 -0.5443 -0.999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 D24 mock treatment 245840.0 -2150.0 -0.06 234040.0 -11500.0 -0.29 -0.2472 -0.8299 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E01 mock treatment 261640.0 13700.0 0.36 234040.0 -11500.0 -0.29 0.0507 0.1086 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E02 mock treatment 220360.0 -27600.0 -0.74 248440.0 2900.0 0.07 -0.4687 -0.6331 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E03 compound treatment 245920.0 -2070.0 -0.06 266280.0 20700.0 0.53 0.334 0.6297 2060173 SPBio_000721 CC(C)C1CCC(C)(O)C2CCC(=CC12)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E04 compound treatment 84040.0 -164000.0 -4.37 88360.0 -157000.0 -4.0 -5.9169 -0.999 2060454 SPBio_000722 Oc1cc(O)c2c(=O)cc(oc2c1)c3cc(O)c(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E05 compound treatment 256920.0 8930.0 0.24 245880.0 344.0 0.01 0.1746 0.7326 3174242 SPBio_000723 OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E06 compound treatment 266520.0 18500.0 0.49 260560.0 15000.0 0.38 0.6195 0.9919 1482 SPBio_000724 CN1CCc2cc3OCOc3cc2C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E07 compound treatment 253320.0 5330.0 0.14 236080.0 -9460.0 -0.24 -0.0695 -0.2488 1000946 SPBio_000725 COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E08 compound treatment 291280.0 43300.0 1.15 269280.0 23700.0 0.6 1.2431 0.9543 1398 SPBio_000726 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC(=O)C)c(C)c(C)c2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E09 compound treatment 256320.0 8330.0 0.22 252240.0 6700.0 0.17 0.2776 0.9914 3078462 SPBio_000727 [Na+].[O-]C(=O)CF 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E10 compound treatment 58640.0 -189000.0 -5.05 77640.0 -168000.0 -4.27 -6.5885 -0.9965 1588 SPBio_000728 CC(=O)C1C(=O)C=C2Oc3c(c(O)c(C)c(O)c3C(=O)C)C2(C)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E11 compound treatment 277200.0 29200.0 0.78 242520.0 -3020.0 -0.08 0.4965 0.6344 465 SPBio_000729 NCCc1c[nH]cn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E12 compound treatment 300840.0 52900.0 1.41 257480.0 11900.0 0.3 1.2112 0.8402 2060490 SPBio_000730 C/C=C(\C)/C(=O)O[C@H]1[C@@H](OC(=O)C)C(C)(C)Oc2ccc3ccc(=O)oc3c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E13 compound treatment 243160.0 -4830.0 -0.13 242000.0 -3540.0 -0.09 -0.1546 -0.9846 1000060 SPBio_000731 COC(=O)C1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E14 compound treatment 236840.0 -11100.0 -0.3 250040.0 4500.0 0.11 -0.1292 -0.4056 1000136 SPBio_000732 CC12CCC3C(=CCc4cc(O)ccc34)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E15 compound treatment 134640.0 -113000.0 -3.02 195560.0 -50000.0 -1.27 -3.0355 -0.9259 1243 SPBio_000733 OC[C@H]1OC(C[C@H]1O)n2cc(F)c(=O)[nH]c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E16 compound treatment 233200.0 -14800.0 -0.39 230440.0 -15100.0 -0.38 -0.5502 -0.9999 2060357 SPBio_000734 CC(=O)O[C@@H]1CC2C(C)(C)CCC(=O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E17 compound treatment 245000.0 -2990.0 -0.08 259040.0 13500.0 0.34 0.1864 0.5289 1498 SPBio_000735 OC(=O)P(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E18 compound treatment 239480.0 -8510.0 -0.23 254680.0 9140.0 0.23 0.004 0.0123 3078271 SPBio_000736 COC(=O)C[C@H]1C(C)(C)[C@H](O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CC[C@H](C3=C)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E19 compound treatment 140800.0 -107000.0 -2.86 155080.0 -90500.0 -2.3 -3.6472 -0.9942 3198319 SPBio_000737 O=C1O[C@]2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E20 compound treatment 243880.0 -4110.0 -0.11 277240.0 31700.0 0.81 0.4925 0.6054 2060049 SPBio_000738 Cc1cc(=O)c2c(O)c(C)c(O)cc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E21 compound treatment 270640.0 22700.0 0.6 235640.0 -9900.0 -0.25 0.2491 0.3808 1290 SPBio_000739 OC(=O)c1ccc(cc1)S(=O)(=O)N(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E22 compound treatment 198400.0 -49600.0 -1.32 255720.0 10200.0 0.26 -0.7518 -0.558 2060435 SPBio_000740 COC(=O)C(OC(=O)C)[C@H]1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E23 mock treatment 255120.0 7130.0 0.19 226200.0 -19300.0 -0.49 -0.2132 -0.4045 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 E24 mock treatment 237040.0 -10900.0 -0.29 294680.0 49100.0 1.25 0.6771 0.5277 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F01 mock treatment 270520.0 22500.0 0.6 231240.0 -14300.0 -0.36 0.1678 0.2389 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F02 mock treatment 240080.0 -7910.0 -0.21 227360.0 -18200.0 -0.46 -0.4759 -0.9368 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F03 compound treatment 242440.0 -5550.0 -0.15 231600.0 -13900.0 -0.35 -0.3552 -0.925 2060314 SPBio_000741 COC(=O)c1c(C)c2Oc3c(Cl)c(OC)c(Cl)c(C)c3C(=O)Oc2c(C)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F04 compound treatment 222240.0 -25700.0 -0.69 199240.0 -46300.0 -1.18 -1.3178 -0.9671 1000048 SPBio_000742 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F05 compound treatment 230560.0 -17400.0 -0.46 235000.0 -10500.0 -0.27 -0.518 -0.9658 401 SPBio_000743 COc1cccc2c1cc([N+](=O)[O-])c3c(cc4OCOc4c23)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F06 compound treatment 261600.0 13600.0 0.36 256840.0 11300.0 0.29 0.4598 0.9933 1537 SPBio_000744 NC(Cc1ccc(F)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F07 compound treatment 174800.0 -73200.0 -1.95 171400.0 -74100.0 -1.89 -2.7128 -0.9999 2060376 SPBio_000745 CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(=O)C)c3C(=O)c12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F08 compound treatment 36800.0 -211000.0 -5.63 40760.0 -205000.0 -5.21 -7.6633 -0.9992 383 SPBio_000746 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccccc5cc4Cn3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F09 compound treatment 249920.0 1930.0 0.05 280760.0 35200.0 0.9 0.6697 0.7465 1334 SPBio_000747 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F10 compound treatment 271840.0 23900.0 0.64 259200.0 13700.0 0.35 0.6953 0.9596 767 SPBio_000748 OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(C#N)c3ccccc3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F11 compound treatment 253480.0 5490.0 0.15 293440.0 47900.0 1.22 0.9648 0.7864 1314 SPBio_000749 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F12 compound treatment 273880.0 25900.0 0.69 374120.0 129000.0 3.27 2.8 0.8379 598 SPBio_000750 Oc1cc2c(=O)oc3c(O)c(O)cc4c(=O)oc(c1O)c2c43 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F13 compound treatment 197360.0 -50600.0 -1.35 155160.0 -90400.0 -2.3 -2.5794 -0.9678 2060316 SPBio_000751 COc1c2C=CC(C)(C)Oc2cc3occ(c4ccc5OCOc5c4)c(=O)c13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F14 compound treatment 304680.0 56700.0 1.51 255800.0 10300.0 0.26 1.2534 0.8171 1539 SPBio_000752 C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)[C@H]23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F15 compound treatment 264400.0 16400.0 0.44 262680.0 17100.0 0.44 0.6176 1.0 960 SPBio_000753 C1N2CN3CN1CN(C2)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F16 compound treatment 262840.0 14900.0 0.4 245280.0 -256.0 -0.01 0.2754 0.6954 1371 SPBio_000754 CN(C)c1nc(nc(n1)N(C)C)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F17 compound treatment 50880.0 -197000.0 -5.26 145560.0 -100000.0 -2.54 -5.5136 -0.9445 437 SPBio_000755 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F18 compound treatment 17040.0 -231000.0 -6.16 18800.0 -227000.0 -5.77 -8.4307 -0.9995 1135 SPBio_000756 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F19 compound treatment 238720.0 -9270.0 -0.25 325200.0 79700.0 2.03 1.2576 0.6163 1005 SPBio_000757 OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F20 compound treatment 267760.0 19800.0 0.53 251400.0 5860.0 0.15 0.4782 0.8729 726 SPBio_000758 CCOC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F21 compound treatment 239760.0 -8230.0 -0.22 257560.0 12000.0 0.31 0.061 0.1622 3078274 SPBio_000759 N[C@H](CO)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F22 compound treatment 387560.0 140000.0 3.72 253360.0 7820.0 0.2 2.772 0.7438 946 SPBio_000760 OCCNC(=O)Cn1ccnc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F23 mock treatment 293520.0 45500.0 1.21 233880.0 -11700.0 -0.3 0.6488 0.5192 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 F24 mock treatment 270960.0 23000.0 0.61 239600.0 -5940.0 -0.15 0.3264 0.5174 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G01 mock treatment 264880.0 16900.0 0.45 259240.0 13700.0 0.35 0.5648 0.992 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G02 mock treatment 261680.0 13700.0 0.37 241960.0 -3580.0 -0.09 0.1938 0.5152 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G03 compound treatment 244200.0 -3790.0 -0.1 235560.0 -9980.0 -0.25 -0.2508 -0.9185 1107153 SPBio_000761 CC(=O)c1cc2C=CC(C)(C)Oc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G04 compound treatment 265760.0 17800.0 0.47 259560.0 14000.0 0.36 0.5872 0.9902 2069251 SPBio_000762 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C[C@H](O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G05 compound treatment 279040.0 31100.0 0.83 267960.0 22400.0 0.57 0.9886 0.9834 1984013 SPBio_000763 C/C=C/c1ccc2OCOc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G06 compound treatment 289200.0 41200.0 1.1 268680.0 23100.0 0.59 1.1931 0.9572 3078272 SPBio_000764 [Na+].[O-]S(=O)(=O)CCS 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G07 compound treatment 238520.0 -9470.0 -0.25 230160.0 -15400.0 -0.39 -0.455 -0.9776 2561 SPBio_000765 Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G08 compound treatment 274800.0 26800.0 0.71 266680.0 21100.0 0.54 0.8856 0.9901 1225 SPBio_000766 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G09 compound treatment 281000.0 33000.0 0.88 265880.0 20300.0 0.52 0.9881 0.9679 2069276 SPBio_000767 COc1cc(cc(OCc2ccccc2)c1OC)c3coc4cc(OCc5ccccc5)c(OC)c(O)c4c3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G10 compound treatment 281800.0 33800.0 0.9 306480.0 60900.0 1.55 1.7332 0.9668 2060402 SPBio_000768 COc1ccc2CC[C@H]3CC(=O)CC[C@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G11 compound treatment 325440.0 77500.0 2.07 288520.0 43000.0 1.09 2.233 0.9557 1001923 SPBio_000769 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G12 compound treatment 74280.0 -174000.0 -4.63 148760.0 -96800.0 -2.46 -5.0149 -0.9562 2069256 SPBio_000770 COc1cc2OCOc2cc1/C=C/C(=O)c3cc(OC)c(OC)cc3OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G13 compound treatment 272960.0 25000.0 0.67 275600.0 30100.0 0.76 1.0113 0.9976 1189 SPBio_000771 CO[C@]1(NC(=O)Cc2cccs2)[C@H]3SCC(=C(N3C1=O)C(=O)O)COC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G14 compound treatment 280440.0 32500.0 0.87 307720.0 62200.0 1.58 1.7298 0.9598 703 SPBio_000772 OC[C@H]1O[C@@H](Oc2ccccc2CO)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G15 compound treatment 342200.0 94200.0 2.51 287320.0 41800.0 1.06 2.5274 0.9267 866 SPBio_000773 Cc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G16 compound treatment 242120.0 -5870.0 -0.16 268840.0 23300.0 0.59 0.3083 0.5031 976 SPBio_000774 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G17 compound treatment 227720.0 -20300.0 -0.54 245600.0 63.8 0.0 -0.381 -0.705 1105 SPBio_000775 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G18 compound treatment 216000.0 -32000.0 -0.85 239960.0 -5580.0 -0.14 -0.7033 -0.8135 2060370 SPBio_000776 COc1cc2OCOc2cc1c3coc4c5C=CC(C)(C)Oc5c(OC)cc4c3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G19 compound treatment 140960.0 -107000.0 -2.85 222920.0 -22600.0 -0.58 -2.4245 -0.8329 2097 SPBio_000777 CCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G20 compound treatment 241200.0 -6790.0 -0.18 254440.0 8900.0 0.23 0.0321 0.1107 935 SPBio_000778 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G21 compound treatment 247080.0 -909.0 -0.02 270920.0 25400.0 0.65 0.4392 0.6801 3174101 SPBio_000779 CN1CCc2c(C1)c3ccccc3n2Cc4ccccc4.OS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G22 compound treatment 202600.0 -45400.0 -1.21 236240.0 -9300.0 -0.24 -1.0229 -0.8295 2060092 SPBio_000780 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CCC3C4CC=C(C(=O)C)[C@@]4(C)C(=O)CC32)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G23 mock treatment 232560.0 -15400.0 -0.41 229000.0 -16500.0 -0.42 -0.5882 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 G24 mock treatment 246800.0 -1190.0 -0.03 245640.0 104.0 0.0 -0.0205 -0.646 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H01 mock treatment 235080.0 -12900.0 -0.34 251960.0 6420.0 0.16 -0.1279 -0.3357 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H02 mock treatment 243400.0 -4590.0 -0.12 235920.0 -9620.0 -0.24 -0.2594 -0.9488 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H03 compound treatment 243720.0 -4270.0 -0.11 227280.0 -18300.0 -0.46 -0.4087 -0.8552 3078275 SPBio_000781 C[C@@H](N)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H04 compound treatment 255440.0 7450.0 0.2 249320.0 3780.0 0.1 0.2085 0.9446 695 SPBio_000782 CC1CCC(CC1)NC(=O)N(CCCl)N=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H05 compound treatment 240760.0 -7230.0 -0.19 245560.0 23.8 0.0 -0.1359 -0.7049 1000069 SPBio_000783 COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c6OCOc6cc7CCN(C)[C@@H](Cc8ccc(Oc1c2)cc8)c75)cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H06 compound treatment 247160.0 -829.0 -0.02 260000.0 14500.0 0.37 0.2444 0.6634 1394 SPBio_000784 BrCCC(=O)N1CCN(CC1)C(=O)CCBr 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H07 compound treatment 235160.0 -12800.0 -0.34 250040.0 4500.0 0.11 -0.1609 -0.446 3078276 SPBio_000785 COC(=O)N/N=C/c1c[n+]([O-])c2ccccc2[n+]1[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H08 compound treatment 223120.0 -24900.0 -0.66 246960.0 1420.0 0.04 -0.4433 -0.6675 3198421 SPBio_000786 CCC(C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)C12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H09 compound treatment 269080.0 21100.0 0.56 269240.0 23700.0 0.6 0.8238 0.9994 3078277 SPBio_000787 CN[C@H]1[C@@H](O)[C@H]2O[C@@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H10 compound treatment 274320.0 26300.0 0.7 274440.0 28900.0 0.73 1.0161 0.9997 1211 SPBio_000788 CON 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H11 compound treatment 255320.0 7330.0 0.2 301120.0 55600.0 1.41 1.1376 0.7973 1001954 SPBio_000789 C/C=C/1\[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(=C2)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H12 compound treatment 268200.0 20200.0 0.54 282800.0 37300.0 0.95 1.051 0.9642 2554 SPBio_000790 C[C@H]1[C@H]2CCC3C4CC=C5C[C@H](CC[C@]5(C)C4CC[C@]23CN1C)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H13 compound treatment 320120.0 72100.0 1.92 336280.0 90700.0 2.31 2.9914 0.9959 3198419 SPBio_000791 COc1ccc2cc3c4cc(OC)c(OC)cc4cc[n+]3cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H14 compound treatment 32160.0 -216000.0 -5.75 42800.0 -203000.0 -5.15 -7.7141 -0.9985 1307 SPBio_000792 ClC(Cl)C(c1ccc(Cl)cc1)c2ccccc2Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H15 compound treatment 270880.0 22900.0 0.61 282080.0 36500.0 0.93 1.0886 0.9792 1017172 SPBio_000793 C=CCSCC=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H16 compound treatment 303240.0 55300.0 1.47 259320.0 13800.0 0.35 1.2895 0.8516 2557 SPBio_000794 COS(=O)(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H17 compound treatment 263360.0 15400.0 0.41 277360.0 31800.0 0.81 0.862 0.9503 1117560 SPBio_000795 CC(=C)C1CCC(=CC1)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H18 compound treatment 238240.0 -9750.0 -0.26 267280.0 21700.0 0.55 0.2071 0.3391 3198422 SPBio_000796 CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H]3OC4(O[C@@H]3[C@@H]2O)O[C@H](C(N)CO)[C@H](O)[C@H](O)[C@H]4O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H19 compound treatment 252440.0 4450.0 0.12 249840.0 4300.0 0.11 0.1613 0.9992 1047 SPBio_000797 CN(C)CCCN1c2ccccc2Sc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H20 compound treatment 263000.0 15000.0 0.4 268640.0 23100.0 0.59 0.6984 0.9825 417 SPBio_000798 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H21 compound treatment 225160.0 -22800.0 -0.61 261240.0 15700.0 0.4 -0.1481 -0.2034 681 SPBio_000799 CC(CN1c2ccccc2Sc3ccccc13)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H22 compound treatment 20080.0 -228000.0 -6.08 21720.0 -224000.0 -5.69 -8.3209 -0.9995 3046992 SPBio_000800 CO[C@]12[C@@H]3NC3CN2C4=C([C@@H]1COC(=O)N)C(=O)C(=C(C)C4=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H23 mock treatment 250480.0 2490.0 0.07 271520.0 26000.0 0.66 0.5141 0.7743 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 H24 mock treatment 241120.0 -6870.0 -0.18 247640.0 2100.0 0.05 -0.0917 -0.4805 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I01 mock treatment 235120.0 -12900.0 -0.34 250640.0 5100.0 0.13 -0.1509 -0.4112 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I02 mock treatment 246880.0 -1110.0 -0.03 247000.0 1460.0 0.04 0.0054 0.1139 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I03 compound treatment 21560.0 -226000.0 -6.04 22560.0 -223000.0 -5.67 -8.2779 -0.9995 647 SPBio_000801 Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I04 compound treatment 246800.0 -1190.0 -0.03 235960.0 -9580.0 -0.24 -0.1946 -0.7925 2060425 SPBio_000802 COC(=O)[C@@H]1OC(=O)[C@H]2O[C@@]23[C@@]1(C)CCC4[C@@]5(C)CCC(=O)C(C)(C)C5C[C@@H](OC(=O)C)[C@]43C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I05 compound treatment 259400.0 11400.0 0.3 238840.0 -6700.0 -0.17 0.0947 0.2717 3174492 SPBio_000803 CN1[C@H]2CC3CC1C(O)C2O3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I06 compound treatment 42560.0 -205000.0 -5.48 41920.0 -204000.0 -5.18 -7.5339 -0.9996 1028 SPBio_000804 Oc1ccc(cc1)C(=C2C=CC(=O)C=C2)c3ccc(O)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I07 compound treatment 236800.0 -11200.0 -0.3 250880.0 5340.0 0.14 -0.1149 -0.3504 1029487 SPBio_000805 OCC(O)Cc1ccc2OCOc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I08 compound treatment 257120.0 9130.0 0.24 244200.0 -1340.0 -0.03 0.1481 0.6026 3198323 SPBio_000806 COc1cc(OC)c2c(=O)c(coc2c1)c3ccc4OCOc4c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I09 compound treatment 290720.0 42700.0 1.14 272240.0 26700.0 0.68 1.2857 0.9694 3078463 SPBio_000807 CCOC(=O)c1c(C)cc(OC)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I10 compound treatment 237800.0 -10200.0 -0.27 247840.0 2300.0 0.06 -0.1507 -0.5422 986 SPBio_000808 CN1CC(=O)NC1=N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I11 compound treatment 261520.0 13500.0 0.36 278000.0 32500.0 0.83 0.8388 0.9311 2060194 SPBio_000809 COc1cc(O)c(C(=O)O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I12 compound treatment 265360.0 17400.0 0.46 270720.0 25200.0 0.64 0.7803 0.9874 1013 SPBio_000810 Cc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I13 compound treatment 257800.0 9810.0 0.26 266960.0 21400.0 0.54 0.5702 0.9435 1514 SPBio_000811 CC1OC1P(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I14 compound treatment 253360.0 5370.0 0.14 268120.0 22600.0 0.57 0.5073 0.8572 1005991 SPBio_000812 O=C1c2ccccc2-c3cccc4cccc1c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I15 compound treatment 22000.0 -226000.0 -6.03 24200.0 -221000.0 -5.63 -8.2401 -0.9994 1191 SPBio_000813 Oc1c(Cl)cc(Cl)c2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I16 compound treatment 237400.0 -10600.0 -0.28 238400.0 -7140.0 -0.18 -0.3279 -0.9772 2777 SPBio_000814 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I17 compound treatment 242520.0 -5470.0 -0.15 285240.0 39700.0 1.01 0.6107 0.5988 3172720 SPBio_000815 CNC(C)[C@@H]1CC[C@@H](N)[C@@H](OC2[C@@H](N)C[C@@H](N)[C@H](OC3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I18 compound treatment 256360.0 8370.0 0.22 251320.0 5780.0 0.15 0.2618 0.9795 1294 SPBio_000816 CCN(CC)Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I19 compound treatment 248560.0 571.0 0.02 241960.0 -3580.0 -0.09 -0.0535 -0.5806 927 SPBio_000817 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I20 compound treatment 270040.0 22100.0 0.59 246720.0 1180.0 0.03 0.437 0.7423 1092 SPBio_000818 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I21 compound treatment 236160.0 -11800.0 -0.32 254200.0 8660.0 0.22 -0.0672 -0.1748 1019607 SPBio_000819 CN(C)Cc1c(C)[nH]c2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I22 compound treatment 218360.0 -29600.0 -0.79 212120.0 -33400.0 -0.85 -1.1594 -0.9993 446 SPBio_000820 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I23 mock treatment 261880.0 13900.0 0.37 225640.0 -19900.0 -0.51 -0.0958 -0.1528 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 I24 mock treatment 234520.0 -13500.0 -0.36 242280.0 -3260.0 -0.08 -0.3125 -0.8479 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J01 mock treatment 246880.0 -1110.0 -0.03 279200.0 33700.0 0.86 0.5843 0.6823 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J02 mock treatment 253000.0 5010.0 0.13 230640.0 -14900.0 -0.38 -0.1733 -0.4316 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J03 compound treatment 260400.0 12400.0 0.33 228720.0 -16800.0 -0.43 -0.0684 -0.1264 1175 SPBio_000821 Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J04 compound treatment 249080.0 1090.0 0.03 239240.0 -6300.0 -0.16 -0.0926 -0.5693 3172714 SPBio_000822 C[n+]1ccccc1/C=N/O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J05 compound treatment 270400.0 22400.0 0.6 237880.0 -7660.0 -0.19 0.2849 0.4533 856 SPBio_000823 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J06 compound treatment 290680.0 42700.0 1.14 243600.0 -1940.0 -0.05 0.7701 0.6759 1000105 SPBio_000824 CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J07 compound treatment 254920.0 6930.0 0.18 236320.0 -9220.0 -0.23 -0.035 -0.1174 1000127 SPBio_000825 CC1(C)O[C@@H]2CC3C4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J08 compound treatment 248040.0 51.3 0.0 246360.0 824.0 0.02 0.0158 0.7516 3471036 SPBio_000826 OC(=O)C1=C(C[n+]2ccccc2)CSC3C(NC(=O)Cc4cccs4)C(=O)N31 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J09 compound treatment 259280.0 11300.0 0.3 348600.0 103000.0 2.62 2.0659 0.7832 1053 SPBio_000827 COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J10 compound treatment 204920.0 -43100.0 -1.15 227400.0 -18100.0 -0.46 -1.1381 -0.9197 1338 SPBio_000828 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J11 compound treatment 259000.0 11000.0 0.29 262520.0 17000.0 0.43 0.513 0.9823 938 SPBio_000829 Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J12 compound treatment 256920.0 8930.0 0.24 259480.0 13900.0 0.35 0.4191 0.9813 1107 SPBio_000830 OC(=O)CN1CCNC1=N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J13 compound treatment 236000.0 -12000.0 -0.32 255640.0 10100.0 0.26 -0.0444 -0.1082 1146 SPBio_000831 Nc1ccc(cc1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J14 compound treatment 257320.0 9330.0 0.25 291720.0 46200.0 1.17 1.0063 0.8383 1271 SPBio_000832 CC(=O)OC(CC(=O)O)[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J15 compound treatment 250240.0 2250.0 0.06 264200.0 18700.0 0.47 0.378 0.7902 721 SPBio_000833 CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J16 compound treatment 228360.0 -19600.0 -0.52 235400.0 -10100.0 -0.26 -0.5523 -0.9468 1142 SPBio_000834 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J17 compound treatment 248080.0 91.3 0.0 265600.0 20100.0 0.51 0.3625 0.7105 2060131 SPBio_000835 CCOC(=O)c1oc2c(OC)c(O)cc(O)c2c(=O)c1c3cc(OC)c(OC)c(OC)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J18 compound treatment 231160.0 -16800.0 -0.45 251920.0 6380.0 0.16 -0.2025 -0.4244 725 SPBio_000836 CC(=C)[C@@H]1CCC(=CC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J19 compound treatment 241040.0 -6950.0 -0.19 243120.0 -2420.0 -0.06 -0.1744 -0.8937 3044782 SPBio_000837 NC(=N)N.OC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J20 compound treatment 256360.0 8370.0 0.22 250480.0 4940.0 0.13 0.2467 0.9631 1372 SPBio_000838 OC(=O)c1cccnc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J21 compound treatment 206560.0 -41400.0 -1.1 225320.0 -20200.0 -0.51 -1.1445 -0.9394 1429 SPBio_000839 CCCCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J22 compound treatment 245920.0 -2070.0 -0.06 246880.0 1340.0 0.03 -0.0148 -0.2288 937 SPBio_000840 CCC(=O)c1ccc2Sc3ccccc3N(CC(C)N(C)C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J23 mock treatment 258440.0 10500.0 0.28 232040.0 -13500.0 -0.34 -0.0456 -0.1032 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 J24 mock treatment 227120.0 -20900.0 -0.56 234920.0 -10600.0 -0.27 -0.5843 -0.9448 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K01 mock treatment 266880.0 18900.0 0.5 254560.0 9020.0 0.23 0.5184 0.9366 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K02 mock treatment 248600.0 611.0 0.02 272560.0 27000.0 0.69 0.4974 0.7237 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K03 compound treatment 256960.0 8970.0 0.24 242320.0 -3220.0 -0.08 0.1113 0.4403 3054976 SPBio_000841 CC(C)[C@@H]1CC[C@@H](C)CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K04 compound treatment 270280.0 22300.0 0.59 320040.0 74500.0 1.89 1.7598 0.8864 3173242 SPBio_000842 Nc1nc2cc(Cl)ccc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K05 compound treatment 259600.0 11600.0 0.31 241640.0 -3900.0 -0.1 0.1489 0.458 2060306 SPBio_000843 C[C@@H](CCOC(=O)C)CCC=C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K06 compound treatment 273920.0 25900.0 0.69 255720.0 10200.0 0.26 0.672 0.9102 2060291 SPBio_000844 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K07 compound treatment 281600.0 33600.0 0.9 290520.0 45000.0 1.14 1.4425 0.9927 3235 SPBio_000845 OC(=O)c1ccccc1OC(=O)c2ccccc2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K08 compound treatment 298760.0 50800.0 1.35 352680.0 107000.0 2.72 2.8836 0.9479 1156 SPBio_000846 OC(=O)c1cc(O)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K09 compound treatment 53760.0 -194000.0 -5.18 64000.0 -182000.0 -4.62 -6.9257 -0.9984 3177523 SPBio_000847 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O)[C@H](C)O2)N(C)C)c3c(O)c4C(=O)c5c(O)ccc(O)c5C(=O)c4cc3[C@H]1C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K10 compound treatment 235400.0 -12600.0 -0.34 290080.0 44500.0 1.13 0.5635 0.477 1308020 SPBio_000848 COc1ccc(cc1)c2cc(=O)c3ccccc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K11 compound treatment 68200.0 -180000.0 -4.79 65360.0 -180000.0 -4.58 -6.629 -0.9997 1056 SPBio_000849 Nc1nc2nc[nH]c2c(=S)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K12 compound treatment 286640.0 38700.0 1.03 251040.0 5500.0 0.14 0.8277 0.7958 1599 SPBio_000850 C=CCc1ccc2OCOc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K13 compound treatment 263480.0 15500.0 0.41 302680.0 57100.0 1.45 1.3195 0.8735 999 SPBio_000851 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K14 compound treatment 308680.0 60700.0 1.62 282800.0 37300.0 0.95 1.8142 0.9675 3058468 SPBio_000852 COc1ccc(OC)c(c1)C(O)C(C)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K15 compound treatment 24080.0 -224000.0 -5.97 59800.0 -186000.0 -4.72 -7.5608 -0.9933 1356 SPBio_000853 Oc1cccc2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K16 compound treatment 260200.0 12200.0 0.33 273840.0 28300.0 0.72 0.7391 0.9357 2553 SPBio_000854 CNNC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K17 compound treatment 19840.0 -228000.0 -6.08 23720.0 -222000.0 -5.64 -8.2894 -0.9993 3198320 SPBio_000855 Clc1ccc(CO/N=C(\Cn2ccnc2)/c3ccc(Cl)cc3Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K18 compound treatment 250240.0 2250.0 0.06 273520.0 28000.0 0.71 0.5456 0.764 422 SPBio_000856 Oc1cccc2C(=O)C=CC(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K19 compound treatment 271760.0 23800.0 0.63 249480.0 3940.0 0.1 0.5191 0.8089 3047 SPBio_000857 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(=C3[C@H]2OC1=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K20 compound treatment 247120.0 -869.0 -0.02 279720.0 34200.0 0.87 0.5982 0.688 3198324 SPBio_000858 C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(O)cc(O)c4c3=O)c5ccc(O)c(O)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K21 compound treatment 342280.0 94300.0 2.51 299320.0 53800.0 1.37 2.7447 0.959 1003215 SPBio_000859 CC(C)C1=CC(=O)C(=CC1=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K22 compound treatment 128800.0 -119000.0 -3.18 267040.0 21500.0 0.55 -1.8605 -0.577 1330 SPBio_000860 ClCCN(CCCl)CCCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K23 mock treatment 238040.0 -9950.0 -0.27 244760.0 -776.0 -0.02 -0.2015 -0.7576 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 K24 mock treatment 236080.0 -11900.0 -0.32 250360.0 4820.0 0.12 -0.1378 -0.4048 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L01 mock treatment 267000.0 19000.0 0.51 235560.0 -9980.0 -0.25 0.1791 0.3159 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L02 mock treatment 264360.0 16400.0 0.44 248040.0 2500.0 0.06 0.3537 0.8018 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L03 compound treatment 249600.0 1610.0 0.04 243760.0 -1780.0 -0.05 -0.0016 -0.025 930 SPBio_000861 CC(CN1CCCCC1)C(=O)c2ccc(C)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L04 compound treatment 296240.0 48300.0 1.29 271200.0 25700.0 0.65 1.3711 0.9505 1325 SPBio_000862 NC1(CCCC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L05 compound treatment 208040.0 -39900.0 -1.07 208320.0 -37200.0 -0.95 -1.4223 -0.9983 2576 SPBio_000863 S=C=NCc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L06 compound treatment 275520.0 27500.0 0.73 254200.0 8660.0 0.22 0.6748 0.8805 3173241 SPBio_000864 C[C@@]12CCC3C(CC[C@H]4C[C@@H](CC[C@@]43C)OS(=O)(=O)O)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L07 compound treatment 101280.0 -147000.0 -3.91 262840.0 17300.0 0.44 -2.4548 -0.6236 1099 SPBio_000865 CC(=O)NCCCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L08 compound treatment 254840.0 6850.0 0.18 271720.0 26200.0 0.67 0.5999 0.869 1266 SPBio_000866 CCn1cc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L09 compound treatment 256800.0 8810.0 0.23 253760.0 8220.0 0.21 0.314 0.9983 850 SPBio_000867 Clc1cccc(c1)N2CCN(CCCn3nc4ccccn4c3=O)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L10 compound treatment 343480.0 95500.0 2.55 273640.0 28100.0 0.71 2.3056 0.8719 1081 SPBio_000868 Cc1c(N)c(=O)n(c2ccccc2)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L11 compound treatment 277240.0 29300.0 0.78 267800.0 22300.0 0.57 0.9518 0.9876 1413 SPBio_000869 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L12 compound treatment 248640.0 651.0 0.02 302320.0 56800.0 1.44 1.0332 0.7156 1000116 SPBio_000870 CC(=O)CC(c1ccccc1)c2c(O)c3ccccc3oc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L13 compound treatment 282840.0 34900.0 0.93 317200.0 71700.0 1.82 1.9455 0.9512 1433 SPBio_000871 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L14 compound treatment 300800.0 52800.0 1.41 310400.0 64900.0 1.65 2.1619 0.9969 1075 SPBio_000872 CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L15 compound treatment 167840.0 -80100.0 -2.14 287440.0 41900.0 1.07 -0.7577 -0.3173 801 SPBio_000873 CN(C)CC/C=C/1\c2ccccc2Sc3ccc(Cl)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L16 compound treatment 256080.0 8090.0 0.22 269560.0 24000.0 0.61 0.5845 0.9022 1201 SPBio_000874 COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L17 compound treatment 263080.0 15100.0 0.4 330600.0 85100.0 2.16 1.8139 0.8245 1278 SPBio_000875 COc1ccc(cc1O)c2cc(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@H](C)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L18 compound treatment 88600.0 -159000.0 -4.25 77120.0 -168000.0 -4.28 -6.033 -1.0 1061 SPBio_000876 Nc1nc(N)c2nc(c(N)nc2n1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L19 compound treatment 220680.0 -27300.0 -0.73 350920.0 105000.0 2.68 1.3799 0.4969 3177517 SPBio_000877 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)C(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L20 compound treatment 261840.0 13900.0 0.37 302160.0 56600.0 1.44 1.2792 0.8606 1341 SPBio_000878 CC(=O)OCC(COC(=O)C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L21 compound treatment 212840.0 -35100.0 -0.94 314440.0 68900.0 1.75 0.5762 0.29 1162 SPBio_000879 Cc1c(NC(=O)c2cccnc2)c(=O)n(c3ccccc3)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L22 compound treatment 15120.0 -233000.0 -6.21 19440.0 -226000.0 -5.75 -8.4554 -0.9993 3173364 SPBio_000880 C[C@H]1[C@@]2(C)CCC3C(CCC4C[C@H](CC[C@@]43C)O[C@H]5O[C@H](CO)[C@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@H]7OC[C@@H](O)[C@H](O)[C@H]7O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]6O)[C@H](O)[C@H]5O)C2O[C@]91CC[C@H](C)CN9 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L23 mock treatment 230680.0 -17300.0 -0.46 295240.0 49700.0 1.26 0.5673 0.4217 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 L24 mock treatment 250280.0 2290.0 0.06 253760.0 8220.0 0.21 0.1911 0.877 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M01 mock treatment 230360.0 -17600.0 -0.47 259440.0 13900.0 0.35 -0.0824 -0.1401 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M02 mock treatment 226000.0 -22000.0 -0.59 231840.0 -13700.0 -0.35 -0.6608 -0.9691 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M03 compound treatment 222240.0 -25700.0 -0.69 224160.0 -21400.0 -0.54 -0.8698 -0.9933 3174245 SPBio_000881 OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M04 compound treatment 52840.0 -195000.0 -5.2 45040.0 -200000.0 -5.1 -7.284 -0.9999 1019365 SPBio_000882 COC1=CC(=O)C=C(OC)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M05 compound treatment 174960.0 -73000.0 -1.95 189920.0 -55600.0 -1.41 -2.3768 -0.9877 2060246 SPBio_000883 C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C/C=C/3\[C@H](O)COC3=O)C(=C)CCC12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M06 compound treatment 230840.0 -17100.0 -0.46 233360.0 -12200.0 -0.31 -0.5422 -0.982 2081029 SPBio_000884 CN/C(=N\C#N)/NCCSCc1nc[nH]c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M07 compound treatment 227560.0 -20400.0 -0.54 228160.0 -17400.0 -0.44 -0.6976 -0.9946 907310 SPBio_000885 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M08 compound treatment 219800.0 -28200.0 -0.75 244760.0 -776.0 -0.02 -0.5454 -0.7254 2060352 SPBio_000886 O=C(O[C@H]1Cc2c(OC(=O)c3ccccc3)cc(OC(=O)c4ccccc4)cc2O[C@@H]1c5ccc(OC(=O)c6ccccc6)c(OC(=O)c7ccccc7)c5)c8ccccc8 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M09 compound treatment 228000.0 -20000.0 -0.53 260200.0 14700.0 0.37 -0.1132 -0.1741 3057880 SPBio_000887 COc1ccc(cc1)C(=C(c2ccc(OC)cc2)c3ccc(OC)cc3)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M10 compound treatment 226440.0 -21500.0 -0.57 244040.0 -1500.0 -0.04 -0.4332 -0.7523 847 SPBio_000888 CC(=CCC/C(=C/CO)/C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M11 compound treatment 230600.0 -17400.0 -0.46 264120.0 18600.0 0.47 0.0063 0.0095 3060195 SPBio_000889 COC(C)(C)CCC[C@H](C)C/C=C/C(=C/C(=O)OC(C)C)/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M12 compound treatment 156720.0 -91300.0 -2.43 184280.0 -61300.0 -1.56 -2.8221 -0.9768 1029 SPBio_000890 CC(C(=O)O)c1ccc(cc1)N2Cc3ccccc3C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M13 compound treatment 244640.0 -3350.0 -0.09 251360.0 5820.0 0.15 0.0416 0.2404 3173342 SPBio_000891 CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)COC(=O)N)\c3ccco3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M14 compound treatment 69520.0 -178000.0 -4.76 103400.0 -142000.0 -3.61 -5.9202 -0.9908 784 SPBio_000892 Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M15 compound treatment 226520.0 -21500.0 -0.57 278600.0 33100.0 0.84 0.1897 0.1865 370 SPBio_000893 O=C1N(C2CCC(=O)NC2=O)C(=O)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M16 compound treatment 19360.0 -229000.0 -6.1 27280.0 -218000.0 -5.55 -8.2345 -0.9989 1195 SPBio_000894 C[C@@]12CCC3C(CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]2(O)CCC1C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M17 compound treatment 15480.0 -233000.0 -6.2 21040.0 -224000.0 -5.71 -8.4198 -0.9992 3198321 SPBio_000895 CCCCCCCC/C=C/CCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M18 compound treatment 225760.0 -22200.0 -0.59 244440.0 -1100.0 -0.03 -0.4388 -0.7395 1256 SPBio_000896 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M19 compound treatment 213000.0 -35000.0 -0.93 231600.0 -13900.0 -0.35 -0.9102 -0.9121 1713087 SPBio_000897 COc1ccc(cc1OC)c2cc(=O)c3ccccc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M20 compound treatment 194320.0 -53700.0 -1.43 206440.0 -39100.0 -0.99 -1.7148 -0.9842 41 SPBio_000898 OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M21 compound treatment 223480.0 -24500.0 -0.65 257920.0 12400.0 0.31 -0.2394 -0.3301 3058622 SPBio_000899 OC1=CC2=C3c4ccc(O)cc4OC[C@]3(O)CC2=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M22 compound treatment 30000.0 -218000.0 -5.81 41560.0 -204000.0 -5.19 -7.7771 -0.9984 2060048 SPBio_000900 CC(=O)c1c(O)c(C)c(O)c2c1oc3c(C(=O)C)c(O)c(C)c(O)c32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M23 mock treatment 228720.0 -19300.0 -0.51 235440.0 -10100.0 -0.26 -0.5448 -0.9486 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 M24 mock treatment 231840.0 -16100.0 -0.43 240360.0 -5180.0 -0.13 -0.3975 -0.8829 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N01 mock treatment 235480.0 -12500.0 -0.33 266560.0 21000.0 0.53 0.1422 0.2256 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N02 mock treatment 246880.0 -1110.0 -0.03 246440.0 904.0 0.02 -0.0047 -0.1243 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N03 compound treatment 231040.0 -16900.0 -0.45 228480.0 -17100.0 -0.43 -0.6262 -0.9998 860 SPBio_000901 CN(C)C(=O)Oc1ccc[n+](C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N04 compound treatment 231920.0 -16100.0 -0.43 242760.0 -2780.0 -0.07 -0.3529 -0.8127 2407 SPBio_000902 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N05 compound treatment 218600.0 -29400.0 -0.78 236640.0 -8900.0 -0.23 -0.714 -0.8755 1268 SPBio_000903 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3cc(C)on3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N06 compound treatment 224760.0 -23200.0 -0.62 248000.0 2460.0 0.06 -0.3936 -0.6324 811 SPBio_000904 CC(=O)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N07 compound treatment 220400.0 -27600.0 -0.74 229520.0 -16000.0 -0.41 -0.8081 -0.9611 1100 SPBio_000905 CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N08 compound treatment 15800.0 -232000.0 -6.19 19160.0 -226000.0 -5.76 -8.4476 -0.9993 928 SPBio_000906 CC(=O)O[Hg]c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N09 compound treatment 14920.0 -233000.0 -6.21 18480.0 -227000.0 -5.77 -8.4764 -0.9993 3173346 SPBio_000907 CC[C@H](C1OC(CC)(C[C@@H]1C)C2CC[C@](O)(CC)[C@H](C)O2)C(=O)C(C)[C@@H](O)[C@H](C)CCc3ccc(C)c(O)c3C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N10 compound treatment 16560.0 -231000.0 -6.17 26160.0 -219000.0 -5.58 -8.3074 -0.9987 1374 SPBio_000908 Oc1c(Br)cc(Br)c2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N11 compound treatment 231600.0 -16400.0 -0.44 237080.0 -8460.0 -0.22 -0.461 -0.9466 1274 SPBio_000909 C1CN2C[C@@H](N=C2S1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N12 compound treatment 231040.0 -16900.0 -0.45 248160.0 2620.0 0.07 -0.2724 -0.5963 816 SPBio_000910 Cc1cc(cc(C)c1CC2=NCCN2)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N13 compound treatment 228240.0 -19700.0 -0.53 252160.0 6620.0 0.17 -0.2532 -0.4581 1232 SPBio_000911 OC1=C(O)C(=O)C(=C(O)C1=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N14 compound treatment 223840.0 -24100.0 -0.64 253560.0 8020.0 0.2 -0.311 -0.4605 471 SPBio_000912 CCCC(CCC)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N15 compound treatment 17920.0 -230000.0 -6.13 23040.0 -222000.0 -5.66 -8.3379 -0.9992 1051 SPBio_000913 CC(=O)Oc1ccc(Cl)c2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N16 compound treatment 224520.0 -23500.0 -0.63 262640.0 17100.0 0.43 -0.1349 -0.1771 1044 SPBio_000914 C[C@H](CCC(=O)O)[C@H]1CCC2C3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N17 compound treatment 213080.0 -34900.0 -0.93 246840.0 1300.0 0.03 -0.6347 -0.6815 975 SPBio_000915 CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N18 compound treatment 214000.0 -34000.0 -0.91 254040.0 8500.0 0.22 -0.4879 -0.5237 1000 SPBio_000916 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N19 compound treatment 227560.0 -20400.0 -0.54 232840.0 -12700.0 -0.32 -0.6134 -0.9688 798 SPBio_000917 CCCCCCOc1ccccc1C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N20 compound treatment 231960.0 -16000.0 -0.43 253000.0 7460.0 0.19 -0.168 -0.3593 977 SPBio_000918 C[C@@]12C[C@H](O)[C@@]3(F)C(CCC4=CC(=O)C=C[C@@]43C)C2C[C@@H](O)[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N21 compound treatment 222480.0 -25500.0 -0.68 219800.0 -25700.0 -0.65 -0.9436 -0.9998 1000115 SPBio_000919 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N22 compound treatment 224400.0 -23600.0 -0.63 218000.0 -27500.0 -0.7 -0.9398 -0.9986 971 SPBio_000920 CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N23 mock treatment 237120.0 -10900.0 -0.29 224840.0 -20700.0 -0.53 -0.577 -0.9605 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 N24 mock treatment 236000.0 -12000.0 -0.32 231080.0 -14500.0 -0.37 -0.4859 -0.9976 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O01 mock treatment 245280.0 -2710.0 -0.07 243280.0 -2260.0 -0.06 -0.0916 -0.9935 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O02 mock treatment 228320.0 -19700.0 -0.52 291320.0 45800.0 1.16 0.4523 0.3543 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O03 compound treatment 260880.0 12900.0 0.34 287080.0 41500.0 1.06 0.99 0.8912 1053058 SPBio_000921 COc1cc(OC)c2c(=O)c(O)c(oc2c1)c3ccc(OC)c(OC)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O04 compound treatment 223840.0 -24100.0 -0.64 241000.0 -4540.0 -0.12 -0.5368 -0.8207 1003514 SPBio_000922 COc1cc(cc(OC)c1OC)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O05 compound treatment 15320.0 -233000.0 -6.2 20360.0 -225000.0 -5.73 -8.4351 -0.9992 3055171 SPBio_000923 COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CCc5c(C)c(O)c(O)cc5[C@]4(C)CC[C@@]3(C)C2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O06 compound treatment 238320.0 -9670.0 -0.26 254880.0 9340.0 0.24 -0.0143 -0.0408 2060483 SPBio_000924 CC(=O)N[C@@H](CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O07 compound treatment 183640.0 -64300.0 -1.72 249880.0 4340.0 0.11 -1.1351 -0.6602 2069289 SPBio_000925 CC(=O)Oc1cc2c(CC3OC34[C@@]2(C)CC[C@@]5(C)C6C[C@@](C)(CC[C@]6(C)CC[C@]45C)C(=O)O)c(C)c1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O08 compound treatment 222680.0 -25300.0 -0.67 276400.0 30900.0 0.78 0.0778 0.0751 3078273 SPBio_000926 COc1cc(C)c(C(=O)Oc2cc(C)c(O)c(C(=O)O)c2C)c(O)c1C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O09 compound treatment 186600.0 -61400.0 -1.64 198840.0 -46700.0 -1.19 -1.9969 -0.9876 3198322 SPBio_000927 CC1CNC(=O)CCC2(C)C(CC(=O)N)C3N4C2=C(C)C5=N6C(=CC7=N8C(=C(C)C9=N(C3(C)C(C)(CC(=O)N)C9CCC(=O)N)[Co+]486(C[C@H]%10OC([C@H](O)[C@@H]%10O)n%11cnc%12c(N)ncnc%11%12)N%13=CN(C%14O[C@H](CO)[C@@H](OP(=O)(O)O1)[C@H]%14O)c%15cc(C)c(C)cc%13%15)C(C)(CC(=O)N)C7CCC(=O)N)C(C)(C)C5CCC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O10 compound treatment 219080.0 -28900.0 -0.77 244200.0 -1340.0 -0.03 -0.569 -0.7376 112 SPBio_000928 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O11 compound treatment 235160.0 -12800.0 -0.34 290080.0 44500.0 1.13 0.559 0.4725 1538 SPBio_000929 Oc1ccc(c(O)c1)c2oc3cc(O)cc(O)c3c(=O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O12 compound treatment 204800.0 -43200.0 -1.15 245120.0 -416.0 -0.01 -0.8217 -0.7136 3198325 SPBio_000930 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O13 compound treatment 264640.0 16700.0 0.44 274200.0 28700.0 0.73 0.8293 0.9717 1343 SPBio_000931 COC1=CC(C)[C@@H]2C[C@H]3OC(=O)C[C@H]4C(=C(OC)C(=O)C([C@@]34C)[C@@]2(C)C1=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O14 compound treatment 235280.0 -12700.0 -0.34 267760.0 22200.0 0.57 0.16 0.2428 2080198 SPBio_000932 CC(=O)C1=C(O)C2C3C(Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O15 compound treatment 259680.0 11700.0 0.31 315960.0 70400.0 1.79 1.4866 0.8179 2069234 SPBio_000933 CN1CCc2cc3OCOc3cc2[C@H]1C4OC(=O)c5c6OCOc6ccc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O16 compound treatment 205680.0 -42300.0 -1.13 262200.0 16700.0 0.42 -0.4981 -0.4133 1353 SPBio_000934 COC(=O)/C(=C/1\OC(=O)C(C1=O)c2ccccc2)/c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O17 compound treatment 120040.0 -128000.0 -3.41 268240.0 22700.0 0.58 -2.0041 -0.5792 3078269 SPBio_000935 OCC(O)CC(O)CCCCCCCCCCCC=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O18 compound treatment 74040.0 -174000.0 -4.64 229480.0 -16100.0 -0.41 -3.5682 -0.7664 2060168 SPBio_000936 C/C(=C/CC1[C@](C)(O)CC[C@H]2C(C)(C)CCC[C@]12C)/C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O19 compound treatment 220120.0 -27900.0 -0.74 283760.0 38200.0 0.97 0.1618 0.1323 1000122 SPBio_000937 O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O20 compound treatment 47080.0 -201000.0 -5.36 18560.0 -227000.0 -5.77 -7.8687 -0.9993 1576 SPBio_000938 CC(=CCc1c(O)c2c(=O)c(coc2c3C=CC(C)(C)Oc13)c4ccc(O)c(O)c4)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O21 compound treatment 251880.0 3890.0 0.1 254000.0 8460.0 0.22 0.2255 0.944 1601 SPBio_000939 COc1c(OC)c2ccc(=O)oc2c3ccoc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O22 compound treatment 258040.0 10100.0 0.27 245920.0 384.0 0.01 0.1964 0.7324 994 SPBio_000940 N[C@@H](CCONC(=N)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O23 mock treatment 246960.0 -1030.0 -0.03 246760.0 1220.0 0.03 0.0026 0.0628 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 O24 mock treatment 259160.0 11200.0 0.3 276160.0 30600.0 0.78 0.7612 0.9131 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P01 mock treatment 268200.0 20200.0 0.54 213920.0 -31600.0 -0.8 -0.1874 -0.1936 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P02 mock treatment 233360.0 -14600.0 -0.39 284960.0 39400.0 1.0 0.433 0.4026 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P03 compound treatment 239120.0 -8870.0 -0.24 270200.0 24700.0 0.63 0.2762 0.4122 1000112 SPBio_000941 CC(=O)O[C@H]1[C@@H](O)C2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P04 compound treatment 217880.0 -30100.0 -0.8 224360.0 -21200.0 -0.54 -0.9484 -0.9811 1000129 SPBio_000942 CC1(C)[C@H](CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P05 compound treatment 140360.0 -108000.0 -2.87 158000.0 -87500.0 -2.23 -3.603 -0.9921 1000045 SPBio_000943 CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)C4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P06 compound treatment 75120.0 -173000.0 -4.61 65680.0 -180000.0 -4.57 -6.4928 -1.0 1004 SPBio_000944 Oc1ccc2c(=O)cc(oc2c1O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P07 compound treatment 213440.0 -34500.0 -0.92 238000.0 -7540.0 -0.19 -0.7869 -0.8363 1450 SPBio_000945 NCCc1c[nH]c2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P08 compound treatment 183360.0 -64600.0 -1.72 246920.0 1380.0 0.04 -1.1936 -0.6925 922 SPBio_000946 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P09 compound treatment 219280.0 -28700.0 -0.77 388720.0 143000.0 3.64 2.0331 0.5465 1586 SPBio_000947 NCCCCNCCCN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P10 compound treatment 140680.0 -107000.0 -2.86 186480.0 -59100.0 -1.5 -3.0849 -0.9547 1106 SPBio_000948 CCC(=O)c1c(O)cc(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P11 compound treatment 227720.0 -20300.0 -0.54 270360.0 24800.0 0.63 0.0642 0.0772 831758 SPBio_000949 Oc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P12 compound treatment 237840.0 -10100.0 -0.27 286920.0 41400.0 1.05 0.5527 0.5087 1533 SPBio_000950 Cc1cc(CC(=O)O)n(C)c1C(=O)c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P13 compound treatment 226840.0 -21100.0 -0.56 261560.0 16000.0 0.41 -0.1106 -0.159 1898 SPBio_000951 OC(=O)CC[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P14 compound treatment 260440.0 12500.0 0.33 328840.0 83300.0 2.12 1.7325 0.8081 1209 SPBio_000952 CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P15 compound treatment 228200.0 -19800.0 -0.53 250680.0 5140.0 0.13 -0.2806 -0.5162 1089854 SPBio_000953 Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P16 compound treatment 237400.0 -10600.0 -0.28 249320.0 3780.0 0.1 -0.1316 -0.4412 1152 SPBio_000954 CN(C)CCN(Cc1ccccc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P17 compound treatment 130800.0 -117000.0 -3.12 155640.0 -89900.0 -2.29 -3.8257 -0.9882 1001531 SPBio_000955 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P18 compound treatment 16640.0 -231000.0 -6.17 170320.0 -75200.0 -1.91 -5.714 -0.8848 3044756 SPBio_000956 CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P19 compound treatment 218160.0 -29800.0 -0.8 249520.0 3980.0 0.1 -0.4907 -0.6121 831 SPBio_000957 Nc1nccs1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P20 compound treatment 222480.0 -25500.0 -0.68 261920.0 16400.0 0.42 -0.1864 -0.2337 1000123 SPBio_000958 CC(=O)OCC(=O)[C@@]1(O)[C@@H](CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P21 compound treatment 350280.0 102000.0 2.73 248400.0 2860.0 0.07 1.98 0.7257 1249 SPBio_000959 C[N+](C)(C)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P22 compound treatment 266160.0 18200.0 0.48 287480.0 41900.0 1.07 1.0967 0.9363 1200 SPBio_000960 NC1C[C@H]1c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P23 mock treatment 257120.0 9130.0 0.24 238200.0 -7340.0 -0.19 0.0403 0.1312 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2160 P24 mock treatment 231280.0 -16700.0 -0.45 237960.0 -7580.0 -0.19 -0.4512 -0.9297 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A01 mock treatment 254520.0 12400.0 0.33 246840.0 6260.0 0.16 0.3458 0.944 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A02 mock treatment 273640.0 31500.0 0.84 239840.0 -745.0 -0.02 0.5804 0.691 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A03 compound treatment 247800.0 5660.0 0.15 226600.0 -14000.0 -0.36 -0.1448 -0.3749 1002 SPBio_000961 CN(C)CCOC(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A04 compound treatment 51240.0 -191000.0 -5.09 27760.0 -213000.0 -5.41 -7.4256 -0.9995 778 SPBio_000962 Oc1c(I)cc(I)c2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A05 compound treatment 13520.0 -229000.0 -6.1 12080.0 -229000.0 -5.81 -8.4187 -0.9997 979 SPBio_000963 S=C1CC=CC=N1O[Zn]On2ccccc2=S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A06 compound treatment 236400.0 -5740.0 -0.15 214840.0 -25700.0 -0.65 -0.5712 -0.8496 1244 SPBio_000964 C[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A07 compound treatment 232800.0 -9340.0 -0.25 186400.0 -54200.0 -1.38 -1.1504 -0.8217 1216 SPBio_000965 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2C[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A08 compound treatment 273600.0 31500.0 0.84 224360.0 -16200.0 -0.41 0.3013 0.3224 890 SPBio_000966 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A09 compound treatment 252760.0 10600.0 0.28 221800.0 -18800.0 -0.48 -0.1376 -0.2478 3177385 SPBio_000967 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A10 compound treatment 254680.0 12500.0 0.33 222760.0 -17800.0 -0.45 -0.0841 -0.1494 1406 SPBio_000968 NC(=O)c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A11 compound treatment 252320.0 10200.0 0.27 240160.0 -425.0 -0.01 0.1842 0.6784 858 SPBio_000969 OCC(O)CN1CCN(CC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A12 compound treatment 206280.0 -35900.0 -0.96 181160.0 -59400.0 -1.51 -1.7446 -0.9756 1123 SPBio_000970 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A13 compound treatment 245800.0 3660.0 0.1 212600.0 -28000.0 -0.71 -0.4342 -0.6046 827 SPBio_000971 CCCCC1(COC(=O)CCC(=O)O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A14 compound treatment 264760.0 22600.0 0.6 238920.0 -1670.0 -0.04 0.3964 0.6558 3173466 SPBio_000972 [O-][N+](=O)c1ccc(/C=N/N2CC(=O)NC2=O)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A15 compound treatment 248920.0 6780.0 0.18 219840.0 -20700.0 -0.53 -0.2452 -0.4398 770 SPBio_000973 CC(CCc1ccccc1)NC(C)C(O)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A16 compound treatment 263280.0 21100.0 0.56 218280.0 -22300.0 -0.57 -0.0026 -0.0032 1077 SPBio_000974 CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A17 compound treatment 267520.0 25400.0 0.68 204760.0 -35800.0 -0.91 -0.1657 -0.146 950 SPBio_000975 Oc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A18 compound treatment 15320.0 -227000.0 -6.05 13360.0 -227000.0 -5.78 -8.3617 -0.9997 814 SPBio_000976 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A19 compound treatment 284960.0 42800.0 1.14 236040.0 -4550.0 -0.12 0.7255 0.6323 776 SPBio_000977 NNc1nncc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A20 compound treatment 295000.0 52900.0 1.41 231880.0 -8710.0 -0.22 0.84 0.5888 3173600 SPBio_000978 Oc1ccc2C[C@H]3N(CC=C)CC[C@]4(C5Oc1c24)[C@@]3(O)CCC5=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A21 compound treatment 206040.0 -36100.0 -0.96 195760.0 -44800.0 -1.14 -1.4866 -0.9965 2797 SPBio_000979 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A22 compound treatment 306800.0 64700.0 1.72 263600.0 23000.0 0.59 1.6328 0.8969 404 SPBio_000980 CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A23 mock treatment 261600.0 19500.0 0.52 247840.0 7260.0 0.18 0.4972 0.9032 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 A24 mock treatment 240520.0 -1620.0 -0.04 254120.0 13500.0 0.34 0.2127 0.6133 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B01 mock treatment 282800.0 40700.0 1.08 264840.0 24300.0 0.62 1.2026 0.9643 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B02 mock treatment 278280.0 36100.0 0.96 246360.0 5780.0 0.15 0.7851 0.8056 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B03 compound treatment 276920.0 34800.0 0.93 233040.0 -7550.0 -0.19 0.52 0.5492 1008060 SPBio_000981 C1CCc2nnnn2CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B04 compound treatment 256080.0 13900.0 0.37 214760.0 -25800.0 -0.66 -0.2016 -0.2672 1086 SPBio_000982 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(c1)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B05 compound treatment 253240.0 11100.0 0.3 239800.0 -785.0 -0.02 0.1951 0.6579 1221 SPBio_000983 CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B06 compound treatment 279160.0 37000.0 0.99 222880.0 -17700.0 -0.45 0.3795 0.3499 1184 SPBio_000984 Nc1ncnc2n(cnc12)C3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B07 compound treatment 236120.0 -6020.0 -0.16 183960.0 -56600.0 -1.44 -1.1317 -0.7811 1058 SPBio_000985 C[C@@]12CCC3C(CCC4=Cc5oncc5C[C@]34C)C2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B08 compound treatment 245120.0 2980.0 0.08 215880.0 -24700.0 -0.63 -0.3881 -0.6129 1434 SPBio_000986 CN1CCN2C(C1)c3ccccc3Cc4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B09 compound treatment 236200.0 -5940.0 -0.16 154000.0 -86600.0 -2.2 -1.6688 -0.7561 1302 SPBio_000987 CC(C)CC1N2C(=O)[C@](NC(=O)C3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(OC2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B10 compound treatment 255320.0 13200.0 0.35 232960.0 -7630.0 -0.19 0.1113 0.2774 965 SPBio_000988 C(C1=NCCN1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B11 compound treatment 175360.0 -66800.0 -1.78 98520.0 -142000.0 -3.61 -3.8133 -0.9469 2060103 SPBio_000989 COc1ccc2C(=O)[C@@H]3[C@@H](COc4cc(OC)c(OC)cc34)Oc2c1CC=C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B12 compound treatment 243160.0 1020.0 0.03 244920.0 4340.0 0.11 0.0971 0.8554 865 SPBio_000990 Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B13 compound treatment 252920.0 10800.0 0.29 226000.0 -14600.0 -0.37 -0.0591 -0.1259 3045298 SPBio_000991 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B14 compound treatment 255480.0 13300.0 0.36 238000.0 -2590.0 -0.07 0.2049 0.5668 1487 SPBio_000992 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B15 compound treatment 239160.0 -2980.0 -0.08 230080.0 -10500.0 -0.27 -0.2451 -0.8796 1412 SPBio_000993 CN(C)CCOC(c1ccc(Cl)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B16 compound treatment 253200.0 11100.0 0.29 223080.0 -17500.0 -0.45 -0.1063 -0.1991 1322 SPBio_000994 COc1cc2ccc(=O)oc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B17 compound treatment 265680.0 23500.0 0.63 221600.0 -19000.0 -0.48 0.1024 0.1293 3198425 SPBio_000995 CC1(C)O[C@@H]2CO[C@@]3(COS(=O)(=O)N)OC(C)(C)O[C@H]3[C@@H]2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B18 compound treatment 260680.0 18500.0 0.49 226680.0 -13900.0 -0.35 0.0995 0.1637 1227 SPBio_000996 NCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B19 compound treatment 262840.0 20700.0 0.55 230800.0 -9790.0 -0.25 0.2143 0.354 775 SPBio_000997 NCC(O)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B20 compound treatment 291280.0 49100.0 1.31 248120.0 7540.0 0.19 1.0618 0.802 142 SPBio_000998 CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B21 compound treatment 267480.0 25300.0 0.68 252920.0 12300.0 0.31 0.6994 0.9391 2069268 SPBio_000999 CC(=O)O[C@H]1CC[C@]2(C)C3CC[C@@]4(C)C(CCC4=O)C3CC=C2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B22 compound treatment 161880.0 -80300.0 -2.14 134920.0 -106000.0 -2.69 -3.413 -0.9936 198 SPBio_001000 CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B23 mock treatment 268880.0 26700.0 0.71 254680.0 14100.0 0.36 0.7575 0.9494 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 B24 mock treatment 259400.0 17300.0 0.46 259680.0 19100.0 0.49 0.6686 0.9996 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C01 mock treatment 254680.0 12500.0 0.33 248480.0 7900.0 0.2 0.3783 0.9703 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C02 mock treatment 256320.0 14200.0 0.38 242760.0 2180.0 0.06 0.3064 0.802 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C03 compound treatment 135480.0 -107000.0 -2.84 93920.0 -147000.0 -3.73 -4.6479 -0.9911 1370 SPBio_001001 C/C=C(/C(=C/C)/c1ccc(O)cc1)\c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C04 compound treatment 256040.0 13900.0 0.37 241480.0 895.0 0.02 0.2781 0.7491 888 SPBio_001002 CC(C)[N+](C)(CCC(C(=O)N)(c1ccccc1)c2ccccc2)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C05 compound treatment 226960.0 -15200.0 -0.4 211680.0 -28900.0 -0.73 -0.806 -0.9605 1301 SPBio_001003 OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C06 compound treatment 256040.0 13900.0 0.37 226480.0 -14100.0 -0.36 0.0084 0.0163 1362 SPBio_001004 COc1c2occc2cc3ccc(=O)oc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C07 compound treatment 203880.0 -38300.0 -1.02 158560.0 -82000.0 -2.09 -2.1962 -0.9459 1468 SPBio_001005 CCCCC(=O)O[C@H]1CCC2C3CCc4cc(O)ccc4C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C08 compound treatment 233120.0 -9020.0 -0.24 226160.0 -14400.0 -0.37 -0.4295 -0.9791 82 SPBio_001006 Nc1cc(nc(N)[n+]1[O-])N2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C09 compound treatment 254240.0 12100.0 0.32 225880.0 -14700.0 -0.37 -0.0363 -0.0736 3177451 SPBio_001007 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C10 compound treatment 232120.0 -10000.0 -0.27 235760.0 -4830.0 -0.12 -0.2757 -0.9376 1083 SPBio_001008 C(C1=NCCN1)c2cccc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C11 compound treatment 235440.0 -6700.0 -0.18 230440.0 -10100.0 -0.26 -0.3088 -0.984 793 SPBio_001009 CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C12 compound treatment 250240.0 8100.0 0.22 258600.0 18000.0 0.46 0.4765 0.9411 953 SPBio_001010 C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C13 compound treatment 250360.0 8220.0 0.22 232080.0 -8510.0 -0.22 0.002 0.0064 826 SPBio_001011 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)CC[C@]5(C)C4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C14 compound treatment 252520.0 10400.0 0.28 229320.0 -11300.0 -0.29 -0.0069 -0.0174 1000108 SPBio_001012 NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C15 compound treatment 231000.0 -11100.0 -0.3 217760.0 -22800.0 -0.58 -0.6205 -0.9517 905 SPBio_001013 CO[C@@H]1[C@@H](OC(=O)N)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C16 compound treatment 227080.0 -15100.0 -0.4 232600.0 -7990.0 -0.2 -0.4276 -0.9501 3173081 SPBio_001014 COCCc1ccc(OCC(O)CNC(C)C)cc1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C17 compound treatment 218800.0 -23300.0 -0.62 211760.0 -28800.0 -0.73 -0.9584 -0.9967 959 SPBio_001015 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C18 compound treatment 223600.0 -18500.0 -0.49 200600.0 -40000.0 -1.02 -1.0685 -0.9451 110 SPBio_001016 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C19 compound treatment 217320.0 -24800.0 -0.66 228680.0 -11900.0 -0.3 -0.6821 -0.9371 700 SPBio_001017 CN1C2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C20 compound treatment 255280.0 13100.0 0.35 214640.0 -25900.0 -0.66 -0.2188 -0.293 3177386 SPBio_001018 NC[C@H]1O[C@H](OC2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C21 compound treatment 236640.0 -5500.0 -0.15 212520.0 -28100.0 -0.71 -0.6084 -0.8351 1127 SPBio_001019 CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C22 compound treatment 225160.0 -17000.0 -0.45 226440.0 -14100.0 -0.36 -0.5745 -0.9935 1508 SPBio_001020 CSCCC(NC=O)C(=O)NC(C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C23 mock treatment 222800.0 -19300.0 -0.52 231400.0 -9190.0 -0.23 -0.5298 -0.9358 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 C24 mock treatment 222520.0 -19600.0 -0.52 232000.0 -8590.0 -0.22 -0.5243 -0.9248 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D01 mock treatment 249760.0 7620.0 0.2 237880.0 -2710.0 -0.07 0.0949 0.4429 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D02 mock treatment 250360.0 8220.0 0.22 224080.0 -16500.0 -0.42 -0.1419 -0.2997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D03 compound treatment 18440.0 -224000.0 -5.96 17640.0 -223000.0 -5.67 -8.2259 -0.9997 820 SPBio_001021 Oc1ccc(Cl)c2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D04 compound treatment 270680.0 28500.0 0.76 235960.0 -4630.0 -0.12 0.4548 0.5908 861 SPBio_001022 C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D05 compound treatment 252960.0 10800.0 0.29 235080.0 -5510.0 -0.14 0.1049 0.3274 1451 SPBio_001023 CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D06 compound treatment 237840.0 -4300.0 -0.11 217760.0 -22800.0 -0.58 -0.4915 -0.8308 3055445 SPBio_001024 CC(=O)OC(C)(C)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D07 compound treatment 249560.0 7420.0 0.2 229120.0 -11500.0 -0.29 -0.0663 -0.1883 1186 SPBio_001025 Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D08 compound treatment 238760.0 -3380.0 -0.09 269760.0 29200.0 0.74 0.4607 0.6165 3172849 SPBio_001026 CN1CCC[C@H]1c2cccnc2.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D09 compound treatment 249280.0 7140.0 0.19 233680.0 -6910.0 -0.18 0.0104 0.0401 2060478 SPBio_001027 CNc1ccc(cc1)C(=O)CC(O)CCC(C)C2OC(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC3(O)CC(O)C(C(CC(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C2C)O3)C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D10 compound treatment 24080.0 -218000.0 -5.81 21160.0 -219000.0 -5.58 -8.0563 -0.9998 1087 SPBio_001028 Oc1ccc(Cl)cc1Cc2cc(Cl)ccc2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D11 compound treatment 238560.0 -3580.0 -0.1 240400.0 -185.0 0.0 -0.0709 -0.741 4480 SPBio_001029 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D12 compound treatment 245600.0 3460.0 0.09 227160.0 -13400.0 -0.34 -0.1762 -0.4984 1190 SPBio_001030 Nc1c2C(O)CCCc2nc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D13 compound treatment 243160.0 1020.0 0.03 249920.0 9340.0 0.24 0.187 0.7827 682 SPBio_001031 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3C(=O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D14 compound treatment 245080.0 2940.0 0.08 243200.0 2620.0 0.07 0.1024 0.9967 1448 SPBio_001032 OC(=O)c1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D15 compound treatment 223520.0 -18600.0 -0.5 227440.0 -13100.0 -0.33 -0.5875 -0.9814 1446 SPBio_001033 OC(COc1cccc2oc(cc(=O)c12)C(=O)O)COc3cccc4oc(cc(=O)c34)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D16 compound treatment 268160.0 26000.0 0.69 250960.0 10400.0 0.26 0.677 0.9123 705 SPBio_001034 CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D17 compound treatment 239080.0 -3060.0 -0.08 228240.0 -12300.0 -0.31 -0.2797 -0.8624 2069333 SPBio_001035 CC[C@H](/C=C/C(C)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D18 compound treatment 246920.0 4780.0 0.13 248520.0 7940.0 0.2 0.2327 0.9754 1577 SPBio_001036 OCC(S)CS 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D19 compound treatment 33880.0 -208000.0 -5.55 55400.0 -185000.0 -4.71 -7.256 -0.9966 1088 SPBio_001037 CCN(CC)CCOc1ccc(cc1)/C(=C(\Cl)/c2ccccc2)/c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D20 compound treatment 248280.0 6140.0 0.16 221240.0 -19300.0 -0.49 -0.2321 -0.4478 3177322 SPBio_001038 CC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D21 compound treatment 234760.0 -7380.0 -0.2 230440.0 -10100.0 -0.26 -0.3216 -0.9911 689 SPBio_001039 Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C(=O)O)s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D22 compound treatment 17640.0 -225000.0 -5.99 18720.0 -222000.0 -5.64 -8.2216 -0.9996 3174103 SPBio_001040 C/C/1=C\CC[C@@]2(C)OC2[C@H]3OC(=O)C(=C)[C@@H]3CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D23 mock treatment 233760.0 -8380.0 -0.22 233360.0 -7230.0 -0.18 -0.288 -0.9952 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 D24 mock treatment 232200.0 -9940.0 -0.27 242840.0 2260.0 0.06 -0.1469 -0.5417 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E01 mock treatment 290120.0 48000.0 1.28 218600.0 -22000.0 -0.56 0.5092 0.3648 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E02 mock treatment 252760.0 10600.0 0.28 235920.0 -4670.0 -0.12 0.1163 0.3789 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E03 compound treatment 244960.0 2820.0 0.08 229200.0 -11400.0 -0.29 -0.1516 -0.507 1265 SPBio_001041 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4c(Cl)cccc4Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E04 compound treatment 233680.0 -8460.0 -0.23 255960.0 15400.0 0.39 0.1169 0.2589 1479 SPBio_001042 CC(C)NCC(O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E05 compound treatment 264240.0 22100.0 0.59 272280.0 31700.0 0.81 0.9864 0.9881 1441 SPBio_001043 CN1CCC(CC1)OC(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E06 compound treatment 257680.0 15500.0 0.41 234560.0 -6030.0 -0.15 0.1846 0.4179 1009 SPBio_001044 C[N+]1(C)C2CC(CC1C3OC32)OC(=O)[C@@H](CO)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E07 compound treatment 216320.0 -25800.0 -0.69 204160.0 -36400.0 -0.93 -1.1418 -0.9893 1363 SPBio_001045 CCOC(=O)CCC(=O)O[C@@H]1[C@H](C[C@@H](C)O[C@H]1O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E08 compound treatment 239280.0 -2860.0 -0.08 227400.0 -13200.0 -0.34 -0.2911 -0.8465 1000107 SPBio_001046 CC(=O)O[C@]1(CCC2C3CCC4=CC(=O)CC[C@@H]4C3CC[C@@]21C)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E09 compound treatment 223000.0 -19100.0 -0.51 237320.0 -3270.0 -0.08 -0.4196 -0.8114 727 SPBio_001047 CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E10 compound treatment 245760.0 3620.0 0.1 280840.0 40300.0 1.02 0.7919 0.7703 879 SPBio_001048 NC[C@H](O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E11 compound treatment 239000.0 -3140.0 -0.08 252440.0 11900.0 0.3 0.1539 0.4918 1222 SPBio_001049 Cn1cnc2n(C)c(=O)[nH]c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E12 compound treatment 245280.0 3140.0 0.08 266560.0 26000.0 0.66 0.5261 0.7903 3173462 SPBio_001050 C[C@H](COc1ccccc1)N[C@@H](C)[C@H](O)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E13 compound treatment 279760.0 37600.0 1.0 287240.0 46700.0 1.19 1.548 0.9965 706 SPBio_001051 Nc1ccc(cc1)S(=O)(=O)Nc2cnc3ccccc3n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E14 compound treatment 243880.0 1740.0 0.05 257960.0 17400.0 0.44 0.3451 0.7769 1169 SPBio_001052 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@H]34)C2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E15 compound treatment 285360.0 43200.0 1.15 252640.0 12100.0 0.31 1.0315 0.8651 3177388 SPBio_001053 COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E16 compound treatment 236440.0 -5700.0 -0.15 228080.0 -12500.0 -0.32 -0.3324 -0.943 1000139 SPBio_001054 CO[C@]1(NC(=O)C(C(=O)O)c2ccc(O)cc2)[C@H]3OCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E17 compound treatment 207640.0 -34500.0 -0.92 209080.0 -31500.0 -0.8 -1.217 -0.9976 876 SPBio_001055 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E18 compound treatment 245640.0 3500.0 0.09 241520.0 935.0 0.02 0.0827 0.8599 800 SPBio_001056 C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E19 compound treatment 143760.0 -98400.0 -2.62 196400.0 -44200.0 -1.12 -2.6493 -0.9284 756 SPBio_001057 CCCCCCc1ccc(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E20 compound treatment 256640.0 14500.0 0.39 241840.0 1260.0 0.03 0.2959 0.7629 1064 SPBio_001058 [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E21 compound treatment 257000.0 14900.0 0.4 237440.0 -3150.0 -0.08 0.2235 0.5532 1174 SPBio_001059 CN(C)CCCN1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E22 compound treatment 220240.0 -21900.0 -0.58 233600.0 -6990.0 -0.18 -0.5386 -0.8822 2935 SPBio_001060 CC(=O)NCc1c(I)c(NC(=O)C)c(I)c(C(=O)O)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E23 mock treatment 252080.0 9940.0 0.26 233360.0 -7230.0 -0.18 0.0574 0.1781 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 E24 mock treatment 245800.0 3660.0 0.1 226360.0 -14200.0 -0.36 -0.1868 -0.4988 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F01 mock treatment 267320.0 25200.0 0.67 236760.0 -3830.0 -0.1 0.4059 0.5984 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F02 mock treatment 268000.0 25900.0 0.69 230880.0 -9710.0 -0.25 0.313 0.4274 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F03 compound treatment 246680.0 4540.0 0.12 250960.0 10400.0 0.26 0.272 0.9375 1114 SPBio_001061 NS(=O)(=O)c1cc2c(N=C(CSCc3ccccc3)NS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F04 compound treatment 240080.0 -2060.0 -0.06 264480.0 23900.0 0.61 0.3907 0.6404 957 SPBio_001062 NC(COC(=O)C=[N+]=[N-])C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F05 compound treatment 258000.0 15900.0 0.42 255640.0 15100.0 0.38 0.5696 0.9988 1001638 SPBio_001063 CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F06 compound treatment 242560.0 416.0 0.01 226680.0 -13900.0 -0.35 -0.2422 -0.6846 3054072 SPBio_001064 OC(=O)CCCCCCCCCCCCC1CCC=C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F07 compound treatment 219000.0 -23100.0 -0.62 253520.0 12900.0 0.33 -0.2038 -0.2914 1337 SPBio_001065 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F08 compound treatment 245160.0 3020.0 0.08 248160.0 7580.0 0.19 0.193 0.9249 1020088 SPBio_001066 NNCc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F09 compound treatment 240080.0 -2060.0 -0.06 251160.0 10600.0 0.27 0.1512 0.5509 3173625 SPBio_001067 Nc1nc2n(cnc2c(=O)[nH]1)C3C[C@H](O)[C@@H](CO)O3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F10 compound treatment 263880.0 21700.0 0.58 248960.0 8380.0 0.21 0.5604 0.9076 2508 SPBio_001068 OC(=O)COc1cc(Cl)c(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F11 compound treatment 243360.0 1220.0 0.03 329800.0 89200.0 2.27 1.6269 0.7171 1031842 SPBio_001069 CC(=O)Oc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F12 compound treatment 288760.0 46600.0 1.24 275400.0 34800.0 0.89 1.5048 0.9862 2477 SPBio_001070 CCOP(=S)(OCC)SCSP(=S)(OCC)OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F13 compound treatment 261840.0 19700.0 0.53 289640.0 49100.0 1.25 1.2533 0.9261 894 SPBio_001071 ClCCN(CCCl)P1(=O)NCCCO1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F14 compound treatment 421680.0 180000.0 4.79 245280.0 4700.0 0.12 3.4692 0.7245 2476 SPBio_001072 CCOP(=S)(OCC)Oc1cc(C)nc(n1)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F15 compound treatment 265600.0 23500.0 0.63 269360.0 28800.0 0.73 0.9596 0.9969 1125 SPBio_001073 CCOC(=O)NNc1nncc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F16 compound treatment 265000.0 22900.0 0.61 248480.0 7900.0 0.2 0.5728 0.8928 2484 SPBio_001074 COP(=O)(OC)OC=C(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F17 compound treatment 276440.0 34300.0 0.91 301600.0 61000.0 1.55 1.7436 0.9682 964 SPBio_001075 CN(C)N=Nc1[nH]cnc1C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F18 compound treatment 199920.0 -42200.0 -1.13 221960.0 -18600.0 -0.47 -1.1309 -0.926 2487 SPBio_001076 CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F19 compound treatment 230200.0 -11900.0 -0.32 245440.0 4860.0 0.12 -0.1379 -0.4037 1480 SPBio_001077 Clc1ccc2oc(=O)[nH]c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F20 compound treatment 252640.0 10500.0 0.28 221320.0 -19300.0 -0.49 -0.1485 -0.2632 2496 SPBio_001078 CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F21 compound treatment 273520.0 31400.0 0.84 245600.0 5020.0 0.13 0.6817 0.8056 2060468 SPBio_001079 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F22 compound treatment 293440.0 51300.0 1.37 230280.0 -10300.0 -0.26 0.7818 0.5614 2523 SPBio_001080 CCOP(=S)(OCC)Oc1nc(Cl)c(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F23 mock treatment 234280.0 -7860.0 -0.21 239360.0 -1230.0 -0.03 -0.1703 -0.8033 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 F24 mock treatment 213360.0 -28800.0 -0.77 238840.0 -1750.0 -0.04 -0.5741 -0.7467 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G01 mock treatment 264360.0 22200.0 0.59 232960.0 -7630.0 -0.19 0.2817 0.4521 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G02 mock treatment 266760.0 24600.0 0.66 222160.0 -18400.0 -0.47 0.1328 0.1647 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G03 compound treatment 264000.0 21900.0 0.58 214920.0 -25700.0 -0.65 -0.0494 -0.0565 915 SPBio_001081 OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G04 compound treatment 312280.0 70100.0 1.87 231200.0 -9390.0 -0.24 1.1536 0.6119 2060472 SPBio_001082 C[C@@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C2CC[C@@]1(O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G05 compound treatment 284960.0 42800.0 1.14 253000.0 12400.0 0.32 1.0304 0.87 3173092 SPBio_001083 CN(C)CCOC(c1ccccc1)c2ccccc2.Cn1c(=O)n(C)c2nc(Cl)[nH]c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G06 compound treatment 250280.0 8140.0 0.22 245320.0 4740.0 0.12 0.2385 0.9614 815 SPBio_001084 CCN(CC)C(=O)c1cccc(C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G07 compound treatment 240640.0 -1500.0 -0.04 246680.0 6100.0 0.15 0.0812 0.5074 3174481 SPBio_001085 CNC[C@@H](O)c1ccc(O)c(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G08 compound treatment 249240.0 7100.0 0.19 266360.0 25800.0 0.66 0.5972 0.8755 772 SPBio_001086 CCN1CCCC(C1)OC(=O)C(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G09 compound treatment 269280.0 27100.0 0.72 229440.0 -11100.0 -0.28 0.3112 0.4005 803 SPBio_001087 CCc1cc(ccn1)C(=S)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G10 compound treatment 230000.0 -12100.0 -0.32 253400.0 12800.0 0.33 0.0014 0.0031 904 SPBio_001088 NC(=O)CN1CCCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G11 compound treatment 261160.0 19000.0 0.51 251480.0 10900.0 0.28 0.5544 0.9596 1150 SPBio_001089 OC(=O)CCCCCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G12 compound treatment 271800.0 29700.0 0.79 268040.0 27500.0 0.7 1.0527 0.9981 1111 SPBio_001090 CCC(C)C1NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(CCNC(=O)C(NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(NC1=O)C(C)CC)C(C)O)NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(NC(=O)C(CCNCS(=O)(=O)O)NC(=O)CCCCC(C)C)C(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G13 compound treatment 296320.0 54200.0 1.44 281440.0 40900.0 1.04 1.7559 0.9869 790 SPBio_001091 COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G14 compound treatment 38000.0 -204000.0 -5.44 35680.0 -205000.0 -5.21 -7.5328 -0.9998 1000054 SPBio_001092 CC(C)CC1NC(=O)C(CCCN)NC(=O)C(NC(=O)C2CCCN2C(=O)C(Cc3ccccc3)NC(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(NC(=O)C4CCCN4C(=O)C(Cc5ccccc5)NC1=O)C(C)C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G15 compound treatment 246680.0 4540.0 0.12 257880.0 17300.0 0.44 0.3965 0.8693 809 SPBio_001093 CNCCC=C1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G16 compound treatment 113400.0 -129000.0 -3.43 102400.0 -138000.0 -3.51 -4.9117 -0.9999 464 SPBio_001094 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G17 compound treatment 222680.0 -19500.0 -0.52 230480.0 -10100.0 -0.26 -0.5486 -0.9474 1181 SPBio_001095 Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G18 compound treatment 238280.0 -3860.0 -0.1 246040.0 5460.0 0.14 0.0252 0.146 1257 SPBio_001096 CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G19 compound treatment 240200.0 -1940.0 -0.05 228720.0 -11900.0 -0.3 -0.25 -0.8166 948 SPBio_001097 O=C1C(C(=O)c2ccccc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G20 compound treatment 17960.0 -224000.0 -5.98 18320.0 -222000.0 -5.65 -8.2228 -0.9996 3046211 SPBio_001098 CCC(C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C/C=C(\C)/[C@@H](OC4C[C@H](OC)C(O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2)C=C[C@@H]1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G21 compound treatment 236320.0 -5820.0 -0.16 216800.0 -23800.0 -0.6 -0.5374 -0.8608 3174102 SPBio_001099 OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G22 compound treatment 233240.0 -8900.0 -0.24 235960.0 -4630.0 -0.12 -0.251 -0.9475 900 SPBio_001100 CN1C(=C(O)c2sccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G23 mock treatment 237320.0 -4820.0 -0.13 231040.0 -9550.0 -0.24 -0.2626 -0.9559 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 G24 mock treatment 207600.0 -34500.0 -0.92 251800.0 11200.0 0.29 -0.4496 -0.4663 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H01 mock treatment 234040.0 -8100.0 -0.22 243240.0 2660.0 0.07 -0.1051 -0.4641 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H02 mock treatment 263520.0 21400.0 0.57 242440.0 1860.0 0.05 0.4364 0.763 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H03 compound treatment 257400.0 15300.0 0.41 233920.0 -6670.0 -0.17 0.1678 0.3808 1104 SPBio_001101 C[C@H](CCC(=O)O)[C@H]1CCC2C3C(CC(=O)[C@]12C)[C@@]4(C)CCC(=O)CC4CC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H04 compound treatment 256200.0 14100.0 0.37 242200.0 1620.0 0.04 0.294 0.7799 2529 SPBio_001102 COP(=S)(OC)Oc1ccc(SC)c(C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H05 compound treatment 245640.0 3500.0 0.09 258440.0 17900.0 0.45 0.3869 0.8349 1430 SPBio_001103 CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H06 compound treatment 275720.0 33600.0 0.9 257360.0 16800.0 0.43 0.9346 0.9425 2531 SPBio_001104 CNC(=O)Oc1ccccc1OC(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H07 compound treatment 226320.0 -15800.0 -0.42 255640.0 15100.0 0.38 -0.0277 -0.0486 1409 SPBio_001105 CCCC(C)(COC(=O)N)COC(=O)NC(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H08 compound treatment 169840.0 -72300.0 -1.93 148520.0 -92100.0 -2.34 -3.0184 -0.9954 2533 SPBio_001106 Clc1ccc(cc1)C(c2ccc(Cl)cc2)C(Cl)(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H09 compound treatment 247960.0 5820.0 0.16 263960.0 23400.0 0.59 0.5299 0.8627 1587 SPBio_001107 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@@H]4O[C@H](CO)[C@@H](O)C[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H10 compound treatment 257120.0 15000.0 0.4 242080.0 1500.0 0.04 0.3092 0.7709 3177463 SPBio_001108 CC1=C(N2C(SC1)[C@H](NC(=O)[C@H](N)C3=CCC=CC3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H11 compound treatment 178680.0 -63500.0 -1.69 203000.0 -37600.0 -0.96 -1.8723 -0.9634 745 SPBio_001109 CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H12 compound treatment 271600.0 29500.0 0.79 283720.0 43100.0 1.1 1.3309 0.9866 835 SPBio_001110 CC(=O)OC1CN2CCC1CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H13 compound treatment 254280.0 12100.0 0.32 279240.0 38700.0 0.98 0.9238 0.8928 436 SPBio_001111 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H14 compound treatment 246800.0 4660.0 0.12 277440.0 36900.0 0.94 0.7504 0.7938 4164 SPBio_001112 CC(C(=O)O)c1ccc2c(c1)[nH]c3ccc(Cl)cc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H15 compound treatment 253600.0 11500.0 0.31 290800.0 50200.0 1.28 1.1188 0.8522 1575 SPBio_001113 CNC1=Nc2ccc(Cl)cc2C(=[N+]([O-])C1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H16 compound treatment 253320.0 11200.0 0.3 275320.0 34700.0 0.88 0.8352 0.896 2060327 SPBio_001114 COc1cc2CCN(C)[C@H]3Oc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c32)cc7)N(C)CCc6cc5OC)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H17 compound treatment 22200.0 -220000.0 -5.86 34680.0 -206000.0 -5.24 -7.8487 -0.9984 3055248 SPBio_001115 C=CC(C1=CC(=O)C=CC1=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H18 compound treatment 229440.0 -12700.0 -0.34 245520.0 4940.0 0.13 -0.1508 -0.4174 1522 SPBio_001116 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H19 compound treatment 243720.0 1580.0 0.04 284360.0 43800.0 1.11 0.8167 0.7333 729 SPBio_001117 OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H20 compound treatment 32400.0 -210000.0 -5.59 31800.0 -209000.0 -5.31 -7.7082 -0.9997 3177316 SPBio_001118 C[C@@H]1O[C@@H](O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H21 compound treatment 281680.0 39500.0 1.05 243000.0 2420.0 0.06 0.7888 0.747 1113841 SPBio_001119 Oc1ccc2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H22 compound treatment 140960.0 -101000.0 -2.7 161280.0 -79300.0 -2.02 -3.3335 -0.9897 3063989 SPBio_001120 C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@@]42OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]4[C@@H]5O[C@@]51C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H23 mock treatment 250760.0 8620.0 0.23 231400.0 -9190.0 -0.23 -0.0027 -0.0083 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 H24 mock treatment 214880.0 -27300.0 -0.73 239880.0 -705.0 -0.02 -0.5267 -0.7243 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I01 mock treatment 234120.0 -8020.0 -0.21 244600.0 4020.0 0.1 -0.0791 -0.3337 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I02 mock treatment 235760.0 -6380.0 -0.17 220080.0 -20500.0 -0.52 -0.489 -0.8917 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I03 compound treatment 218040.0 -24100.0 -0.64 226120.0 -14500.0 -0.37 -0.7145 -0.9649 969 SPBio_001121 CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I04 compound treatment 232560.0 -9580.0 -0.26 238000.0 -2590.0 -0.07 -0.2272 -0.861 2558 SPBio_001122 c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I05 compound treatment 256000.0 13900.0 0.37 247200.0 6620.0 0.17 0.3802 0.9365 3174228 SPBio_001123 CN[C@H]1C(O)C(O)C(CO)OC1OC2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)OC(C)[C@]2(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I06 compound treatment 262520.0 20400.0 0.54 246480.0 5900.0 0.15 0.4901 0.8697 1009654 SPBio_001124 COc1ccc(cc1OC)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I07 compound treatment 263320.0 21200.0 0.56 193960.0 -46600.0 -1.19 -0.4391 -0.3344 1224 SPBio_001125 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@H]1OC(=O)CCC5CCCC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I08 compound treatment 253840.0 11700.0 0.31 246480.0 5900.0 0.15 0.3265 0.9436 1012 SPBio_001126 Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I09 compound treatment 220800.0 -21300.0 -0.57 199120.0 -41500.0 -1.05 -1.1479 -0.9581 1139 SPBio_001127 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I10 compound treatment 35440.0 -207000.0 -5.51 35720.0 -205000.0 -5.21 -7.5804 -0.9996 3172974 SPBio_001128 C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)C4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I11 compound treatment 236000.0 -6140.0 -0.16 264080.0 23500.0 0.6 0.3066 0.4949 1188 SPBio_001129 NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I12 compound treatment 243360.0 1220.0 0.03 242640.0 2060.0 0.05 0.0599 0.9736 1206 SPBio_001130 CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@@]53C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I13 compound treatment 259040.0 16900.0 0.45 223200.0 -17400.0 -0.44 0.006 0.0095 1215 SPBio_001131 CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I14 compound treatment 246200.0 4060.0 0.11 288920.0 48300.0 1.23 0.9455 0.7664 3078331 SPBio_001132 OC(=O)c1cccc(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I15 compound treatment 261280.0 19100.0 0.51 253560.0 13000.0 0.33 0.5941 0.9777 1219 SPBio_001133 CC[C@@]12CCC3C(CCC4=CC(=O)CC[C@H]34)C2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I16 compound treatment 109840.0 -132000.0 -3.53 97720.0 -143000.0 -3.63 -5.063 -0.9999 810 SPBio_001134 CCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I17 compound treatment 249960.0 7820.0 0.21 277440.0 36900.0 0.94 0.81 0.8437 838 SPBio_001135 COc1ccc(C(=O)c2ccccc2)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I18 compound treatment 15640.0 -227000.0 -6.04 18560.0 -222000.0 -5.65 -8.2622 -0.9994 704 SPBio_001136 CN(C)c1ccc(cc1)C(=C2C=CC(=[N+](C)C)C=C2)c3ccc(cc3)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I19 compound treatment 245680.0 3540.0 0.09 248520.0 7940.0 0.2 0.2093 0.94 3273 SPBio_001137 NNCCc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I20 compound treatment 245320.0 3180.0 0.08 231280.0 -9310.0 -0.24 -0.1074 -0.4275 1585 SPBio_001138 CC(C)c1ccc(C)c2ccc(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I21 compound treatment 265400.0 23300.0 0.62 231280.0 -9310.0 -0.24 0.2711 0.4086 1131 SPBio_001139 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I22 compound treatment 153440.0 -88700.0 -2.37 163360.0 -77200.0 -1.96 -3.0608 -0.9957 1000377 SPBio_001140 CC(C)c1nc(nc(c1/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c2ccc(F)cc2)N(C)S(=O)(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I23 mock treatment 239640.0 -2500.0 -0.07 230440.0 -10100.0 -0.26 -0.2296 -0.8617 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 I24 mock treatment 214320.0 -27800.0 -0.74 230840.0 -9750.0 -0.25 -0.6998 -0.8947 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J01 mock treatment 234200.0 -7940.0 -0.21 251960.0 11400.0 0.29 0.0547 0.1527 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J02 mock treatment 259440.0 17300.0 0.46 227920.0 -12700.0 -0.32 0.0984 0.1749 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J03 compound treatment 250480.0 8340.0 0.22 261040.0 20500.0 0.52 0.5249 0.9281 1000134 SPBio_001141 Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J04 compound treatment 243440.0 1300.0 0.03 241760.0 1180.0 0.03 0.0456 0.9974 1000093 SPBio_001142 CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J05 compound treatment 239720.0 -2420.0 -0.06 239640.0 -945.0 -0.02 -0.0627 -0.9092 1113 SPBio_001143 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(=O)O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J06 compound treatment 242160.0 15.6 0.0 237000.0 -3590.0 -0.09 -0.0642 -0.7039 2141064 SPBio_001144 COC1=C[C@@H]2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J07 compound treatment 192280.0 -49900.0 -1.33 170120.0 -70500.0 -1.79 -2.207 -0.9892 3055370 SPBio_001145 COC(=O)c1c(C)c2Oc3c(Cl)c(OC(=O)C)c(Cl)c(C)c3C(=O)Oc2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J08 compound treatment 20200.0 -222000.0 -5.92 23240.0 -217000.0 -5.53 -8.0921 -0.9994 3079387 SPBio_001146 CN(/C=N/c1ccc(C)cc1C)/C=N/c2ccc(C)cc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J09 compound treatment 96760.0 -145000.0 -3.88 96800.0 -144000.0 -3.66 -5.3261 -0.9996 2069224 SPBio_001147 COc1ccc(cc1)c2c(O)c3cc4CCC(C)(C)Oc4c(CC=C(C)C)c3oc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J10 compound treatment 258960.0 16800.0 0.45 238760.0 -1830.0 -0.05 0.2842 0.6306 3177525 SPBio_001148 NCCCC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J11 compound treatment 252360.0 10200.0 0.27 277760.0 37200.0 0.95 0.861 0.8753 2060359 SPBio_001149 COc1ccc(cc1)c2c(O)c3c(OC)c4C=CC(C)(C)Oc4cc3oc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J12 compound treatment 249000.0 6860.0 0.18 245800.0 5220.0 0.13 0.223 0.9876 885 SPBio_001150 Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J13 compound treatment 19840.0 -222000.0 -5.93 20680.0 -220000.0 -5.59 -8.1449 -0.9996 2060346 SPBio_001151 CC(=O)Oc1cc2c(CC=C3[C@@]2(C)CC[C@@]4(C)C5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O)c(C)c1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J14 compound treatment 32840.0 -209000.0 -5.58 34760.0 -206000.0 -5.23 -7.6467 -0.9995 3046390 SPBio_001152 CCC(=O)O[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J15 compound treatment 208120.0 -34000.0 -0.91 188480.0 -52100.0 -1.32 -1.5783 -0.9829 2060444 SPBio_001153 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J16 compound treatment 32400.0 -210000.0 -5.59 23040.0 -218000.0 -5.53 -7.8657 -1.0 3198427 SPBio_001154 CCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J17 compound treatment 235760.0 -6380.0 -0.17 254160.0 13600.0 0.35 0.1237 0.3214 2060377 SPBio_001155 COc1c(ccc2OC(C)(C)CCc12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J18 compound treatment 255880.0 13700.0 0.37 267320.0 26700.0 0.68 0.7396 0.9579 1072288 SPBio_001156 CC(=C)C1CNC(C1CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J19 compound treatment 242920.0 776.0 0.02 256080.0 15500.0 0.39 0.2932 0.7432 2060190 SPBio_001157 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4C(=O)[C@@H](OC(=O)C)[C@]23C)OC(=O)C)O[C@@]61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J20 compound treatment 262640.0 20500.0 0.55 235880.0 -4710.0 -0.12 0.3018 0.5395 3198428 SPBio_001158 CCOC(=O)[C@H](CCc1ccccc1)N[C@H](C)C(=O)N2[C@@H](CC3CCCCC32)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J21 compound treatment 246880.0 4740.0 0.13 229920.0 -10700.0 -0.27 -0.1025 -0.3426 1312 SPBio_001159 C[As](=O)(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J22 compound treatment 207040.0 -35100.0 -0.94 197280.0 -43300.0 -1.1 -1.4404 -0.9967 1078453 SPBio_001160 Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J23 mock treatment 257960.0 15800.0 0.42 234400.0 -6190.0 -0.16 0.187 0.4154 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 J24 mock treatment 215680.0 -26500.0 -0.71 226880.0 -13700.0 -0.35 -0.7453 -0.9471 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K01 mock treatment 205920.0 -36200.0 -0.97 246200.0 5620.0 0.14 -0.582 -0.5961 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K02 mock treatment 229320.0 -12800.0 -0.34 249040.0 8460.0 0.21 -0.0898 -0.2223 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K03 compound treatment 266320.0 24200.0 0.64 263560.0 23000.0 0.58 0.8689 0.9988 1024 SPBio_001161 c1ccc2c(c1)sc3ccccc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K04 compound treatment 180360.0 -61800.0 -1.65 192960.0 -47600.0 -1.21 -2.0211 -0.9885 2566 SPBio_001162 CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K05 compound treatment 234760.0 -7380.0 -0.2 266080.0 25500.0 0.65 0.3192 0.4711 1518 SPBio_001163 OC(=O)c1cc(ccc1O)c2ccc(F)cc2F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K06 compound treatment 263720.0 21600.0 0.58 235640.0 -4950.0 -0.13 0.3179 0.5398 3198423 SPBio_001164 CO/N=C/1\CN(CC1CN)c2nc3n(cc(C(=O)O)c(=O)c3cc2F)C4CC4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K07 compound treatment 166200.0 -75900.0 -2.02 170400.0 -70200.0 -1.78 -2.6937 -0.998 1240 SPBio_001165 CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K08 compound treatment 209920.0 -32200.0 -0.86 200480.0 -40100.0 -1.02 -1.3286 -0.9964 2060461 SPBio_001166 COc1ccc(C2COc3c(OC)c(O)ccc3C2)c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K09 compound treatment 245280.0 3140.0 0.08 248240.0 7660.0 0.19 0.1967 0.9288 1176 SPBio_001167 CC[C@@H](CO)NCCN[C@@H](CC)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K10 compound treatment 222320.0 -19800.0 -0.53 311240.0 70700.0 1.8 0.8966 0.4788 2560 SPBio_001168 Cc1ccc2cc3c(ccc4ccccc43)c5CCc1c52 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K11 compound treatment 239120.0 -3020.0 -0.08 305640.0 65100.0 1.65 1.1126 0.6718 3043753 SPBio_001169 [O-][N+](=O)c1ccc(/C=N/N2CCOC2=O)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K12 compound treatment 238880.0 -3260.0 -0.09 293800.0 53200.0 1.35 0.8952 0.6603 2060305 SPBio_001170 CCCCC[C@H](CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K13 compound treatment 230960.0 -11200.0 -0.3 176440.0 -64100.0 -1.63 -1.3641 -0.8228 1000104 SPBio_001171 Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K14 compound treatment 75480.0 -167000.0 -4.44 126360.0 -114000.0 -2.9 -5.1959 -0.9788 1661997 SPBio_001172 CC12CCC3C(CCc4cc(OC(=O)c5ccccc5)ccc34)C2CCC1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K15 compound treatment 227760.0 -14400.0 -0.38 241120.0 535.0 0.01 -0.2616 -0.6816 747 SPBio_001173 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K16 compound treatment 211920.0 -30200.0 -0.81 289360.0 48800.0 1.24 0.3071 0.2076 796 SPBio_001174 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K17 compound treatment 243120.0 976.0 0.03 250680.0 10100.0 0.26 0.1999 0.7748 996 SPBio_001175 NCCc1cc(O)c(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K18 compound treatment 237120.0 -5020.0 -0.13 262440.0 21900.0 0.56 0.2982 0.5217 3173859 SPBio_001176 CC(C)CC(=O)OC1C(O[C@@H]2C[C@H]([C@H]3CC[C@]4(CC5CC[C@H]4[C@]3(C)C2)[C@@H](O)C5=C)C(=O)O)OC(CO)C(OS(=O)(=O)O)C1OS(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K19 compound treatment 277360.0 35200.0 0.94 246320.0 5740.0 0.15 0.767 0.8072 958 SPBio_001177 NC(=O)NC(=O)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K20 compound treatment 19880.0 -222000.0 -5.93 21800.0 -219000.0 -5.56 -8.124 -0.9995 1324 SPBio_001178 CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K21 compound treatment 252520.0 10400.0 0.28 295080.0 54500.0 1.39 1.1754 0.8319 881 SPBio_001179 CC12C[C@H](O)C3C(CCC4=CC(=O)CCC34C)C2CC[C@]1(O)C(=O)COP(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K22 compound treatment 234600.0 -7540.0 -0.2 227560.0 -13000.0 -0.33 -0.3764 -0.9714 1000411 SPBio_001180 CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K23 mock treatment 266200.0 24100.0 0.64 227360.0 -13200.0 -0.34 0.2158 0.2979 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 K24 mock treatment 220600.0 -21500.0 -0.57 253800.0 13200.0 0.34 -0.1686 -0.2533 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L01 mock treatment 203320.0 -38800.0 -1.04 292800.0 52200.0 1.33 0.2068 0.1229 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L02 mock treatment 258360.0 16200.0 0.43 283840.0 43300.0 1.1 1.0834 0.9168 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L03 compound treatment 230360.0 -11800.0 -0.31 291960.0 51400.0 1.31 0.7015 0.5221 3198426 SPBio_001181 NCC(CC(=O)O)c1ccc(Cl)s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L04 compound treatment 363640.0 121000.0 3.24 251920.0 11300.0 0.29 2.4944 0.767 3069053 SPBio_001182 CCOC(=O)n1ccn(C)c1=S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L05 compound treatment 274640.0 32500.0 0.87 243960.0 3380.0 0.09 0.6733 0.7734 3202 SPBio_001183 COc1ccccc1N2CCN(CCCNc3cc(=O)n(C)c(=O)n3C)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L06 compound treatment 292640.0 50500.0 1.35 274600.0 34000.0 0.86 1.5636 0.9771 2069303 SPBio_001184 COC(=O)CCC(=O)O[C@H]1CCC2(C)C(CCC3C4CC5OC6(CCC(C)CO6)[C@@H](C)C5C4(C)[C@H](O)C(=O)C32)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L07 compound treatment 26440.0 -216000.0 -5.75 31320.0 -209000.0 -5.32 -7.8292 -0.9992 3177465 SPBio_001185 CO[C@@H]1C[C@H](O[C@H]2CC[C@@]3(C)[C@H](CCC4C3CC[C@]5(C)[C@H]([C@H](C[C@]45O)OC(=O)C)C6=CC(=O)OC6)C2)OC(C)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L08 compound treatment 195640.0 -46500.0 -1.24 99640.0 -141000.0 -3.58 -3.4108 -0.8994 3054136 SPBio_001186 CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L09 compound treatment 223000.0 -19100.0 -0.51 240840.0 255.0 0.01 -0.3563 -0.6981 1000807 SPBio_001187 CN1CCN(CC1)C(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L10 compound treatment 125080.0 -117000.0 -3.12 126840.0 -114000.0 -2.89 -4.2521 -0.9993 2060309 SPBio_001188 CC12CCC3C(CCC4(O)CC(O)CCC34/C=N/NC(=O)N)C2(O)CCC1C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L11 compound treatment 31600.0 -211000.0 -5.61 40880.0 -200000.0 -5.08 -7.56 -0.9987 3174220 SPBio_001189 CO[C@@H]1C[C@@H](C[C@H]2CC[C@H](C)[C@@H](O2)[C@@H](C)C(=O)O)O[C@]3(O[C@@](C)(C[C@H]3C)[C@H]4CC[C@](C)(O4)C5O[C@H](C[C@@H]5C)C6O[C@@](O)(CO)[C@H](C)C[C@@H]6C)[C@@H]1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L12 compound treatment 267360.0 25200.0 0.67 252720.0 12100.0 0.31 0.6936 0.9376 3079388 SPBio_001190 COc1ccc2CC[C@H]3C[C@H](O)CC[C@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L13 compound treatment 18400.0 -224000.0 -5.97 21360.0 -219000.0 -5.57 -8.1598 -0.9994 2038 SPBio_001191 CCN(CC)C(=S)SSC(=S)N(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L14 compound treatment 267840.0 25700.0 0.69 230320.0 -10300.0 -0.26 0.2999 0.409 967 SPBio_001192 C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)/C=C/C=C(\C)/C=C/C2=C(C)CCCC2(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L15 compound treatment 225400.0 -16700.0 -0.45 305760.0 65200.0 1.66 0.8561 0.4988 1589 SPBio_001193 CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L16 compound treatment 250640.0 8500.0 0.23 300800.0 60200.0 1.53 1.2428 0.803 418 SPBio_001194 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L17 compound treatment 236120.0 -6020.0 -0.16 285360.0 44800.0 1.14 0.6914 0.6014 1214 SPBio_001195 CCOC(=O)Nc1c[n+](no1)N2CCOCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L18 compound treatment 228440.0 -13700.0 -0.37 273760.0 33200.0 0.84 0.3381 0.3678 1293 SPBio_001196 CC(=O)OCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L19 compound treatment 227840.0 -14300.0 -0.38 252880.0 12300.0 0.31 -0.0486 -0.0986 3480106 SPBio_001197 CC(C)(C(=O)O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L20 compound treatment 251080.0 8940.0 0.24 245320.0 4740.0 0.12 0.2536 0.95 746 SPBio_001198 C(N(Cc1ccccc1)c2ccccc2)C3=NCCN3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L21 compound treatment 222440.0 -19700.0 -0.53 223040.0 -17500.0 -0.45 -0.6869 -0.9967 3000787 SPBio_001199 [O-][N+](=O)c1ccc(cc1)c2ccc(/C=N/N3CC(=O)NC3=O)o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L22 compound treatment 245440.0 3300.0 0.09 235520.0 -5070.0 -0.13 -0.0289 -0.1856 3177462 SPBio_001200 CCCCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(O)C[C@@]21C)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L23 mock treatment 199000.0 -43100.0 -1.15 233880.0 -6710.0 -0.17 -0.934 -0.8031 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 L24 mock treatment 228800.0 -13300.0 -0.36 229000.0 -11600.0 -0.29 -0.4599 -0.9956 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M01 mock treatment 220240.0 -21900.0 -0.58 262640.0 22100.0 0.56 -0.0164 -0.0203 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M02 mock treatment 218000.0 -24100.0 -0.64 237120.0 -3470.0 -0.09 -0.5175 -0.7965 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M03 compound treatment 215520.0 -26600.0 -0.71 210960.0 -29600.0 -0.75 -1.0346 -0.9996 1018 SPBio_001201 COc1ccc2C[C@H]3[C@@H]4CCCC[C@@]4(CCN3C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M04 compound treatment 215240.0 -26900.0 -0.72 231200.0 -9390.0 -0.24 -0.676 -0.8942 1696 SPBio_001202 CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M05 compound treatment 222760.0 -19400.0 -0.52 226040.0 -14500.0 -0.37 -0.627 -0.9865 1164 SPBio_001203 CCN(CC)C(=O)N1CCN(C)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M06 compound treatment 219360.0 -22800.0 -0.61 228760.0 -11800.0 -0.3 -0.6422 -0.9474 1012497 SPBio_001204 NC(Cc1c[nH]c2ccccc12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M07 compound treatment 212120.0 -30000.0 -0.8 233120.0 -7470.0 -0.19 -0.7003 -0.8512 1378 SPBio_001205 NCCc1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M08 compound treatment 200520.0 -41600.0 -1.11 251640.0 11100.0 0.28 -0.586 -0.5119 3055 SPBio_001206 NC(=N)NCCN1CCCCCCC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M09 compound treatment 225040.0 -17100.0 -0.46 255280.0 14700.0 0.37 -0.0583 -0.0988 1462 SPBio_001207 CC1C(CCC(C)(C)N1C)OC(=O)C(O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M10 compound treatment 226680.0 -15500.0 -0.41 275960.0 35400.0 0.9 0.3445 0.3481 896 SPBio_001208 COc1ccccc1OCC(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M11 compound treatment 231800.0 -10300.0 -0.28 257880.0 17300.0 0.44 0.1159 0.2233 1000135 SPBio_001209 CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M12 compound treatment 18120.0 -224000.0 -5.97 23440.0 -217000.0 -5.52 -8.1277 -0.9992 1238 SPBio_001210 Oc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M13 compound treatment 77240.0 -165000.0 -4.4 98880.0 -142000.0 -3.6 -5.6567 -0.9951 2117626 SPBio_001211 Fc1ccc(cc1)C(CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34)c5ccc(F)cc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M14 compound treatment 222400.0 -19700.0 -0.53 233640.0 -6950.0 -0.18 -0.4971 -0.8953 1344 SPBio_001212 CCCC(=O)O[C@@]1(CCC2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@@]21C)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M15 compound treatment 199320.0 -42800.0 -1.14 227320.0 -13300.0 -0.34 -1.0459 -0.8785 1115 SPBio_001213 C[C@@]12CCC3C(CCC4=C3CCC(=O)C4)C2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M16 compound treatment 18880.0 -223000.0 -5.95 39360.0 -201000.0 -5.12 -7.8271 -0.9972 3055280 SPBio_001214 CCCCCCc1ccc(O)cc1O.Nc1c2ccccc2nc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M17 compound treatment 225080.0 -17100.0 -0.45 238400.0 -2190.0 -0.06 -0.361 -0.7876 3173215 SPBio_001215 Cc1onc(c1C(=O)NC2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M18 compound treatment 214200.0 -27900.0 -0.75 220080.0 -20500.0 -0.52 -0.8955 -0.9848 1001518 SPBio_001216 CCC[C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCCC[C@@H]21)C(=O)O)C(=O)OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M19 compound treatment 212520.0 -29600.0 -0.79 214000.0 -26600.0 -0.68 -1.0365 -0.997 952 SPBio_001217 CC(C)(S)[C@@H](N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M20 compound treatment 229280.0 -12900.0 -0.34 249040.0 8460.0 0.21 -0.0905 -0.2236 732 SPBio_001218 Oc1cc(cc([N+](=O)[O-])c1O)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M21 compound treatment 231800.0 -10300.0 -0.28 228440.0 -12100.0 -0.31 -0.4134 -0.9984 848 SPBio_001219 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M22 compound treatment 210640.0 -31500.0 -0.84 220840.0 -19700.0 -0.5 -0.949 -0.9697 1402 SPBio_001220 CC[N+](C)(C)c1cccc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M23 mock treatment 210960.0 -31200.0 -0.83 224400.0 -16200.0 -0.41 -0.8789 -0.9474 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 M24 mock treatment 206200.0 -35900.0 -0.96 241080.0 495.0 0.01 -0.6688 -0.6978 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N01 mock treatment 243160.0 1020.0 0.03 239840.0 -745.0 -0.02 0.0058 0.1741 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N02 mock treatment 246360.0 4220.0 0.11 237200.0 -3390.0 -0.09 0.0186 0.1315 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N03 compound treatment 228840.0 -13300.0 -0.35 221280.0 -19300.0 -0.49 -0.5979 -0.9873 1331 SPBio_001221 CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N04 compound treatment 235120.0 -7020.0 -0.19 227600.0 -13000.0 -0.33 -0.3659 -0.9639 451 SPBio_001222 Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N05 compound treatment 204680.0 -37500.0 -1.0 227240.0 -13300.0 -0.34 -0.9463 -0.897 1494 SPBio_001223 C1CN(CCN1)c2ccc3ccccc3n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N06 compound treatment 21600.0 -221000.0 -5.88 29600.0 -211000.0 -5.36 -7.9513 -0.999 1454 SPBio_001224 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CCC6C5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N07 compound treatment 24280.0 -218000.0 -5.81 50080.0 -191000.0 -4.84 -7.5326 -0.9959 1313 SPBio_001225 Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N08 compound treatment 172840.0 -69300.0 -1.85 216760.0 -23800.0 -0.61 -1.735 -0.8922 935 SPBio_001226 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N09 compound treatment 211920.0 -30200.0 -0.81 254400.0 13800.0 0.35 -0.3214 -0.3657 806 SPBio_001227 OC(=O)C1CCCNC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N10 compound treatment 227800.0 -14300.0 -0.38 255560.0 15000.0 0.38 -0.0012 -0.0022 1297 SPBio_001228 COc1cc(CC=C)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N11 compound treatment 206440.0 -35700.0 -0.95 231480.0 -9110.0 -0.23 -0.8368 -0.8542 1258 SPBio_001229 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCNCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N12 compound treatment 218880.0 -23300.0 -0.62 261760.0 21200.0 0.54 -0.0579 -0.0705 945 SPBio_001230 C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N13 compound treatment 209680.0 -32500.0 -0.87 228840.0 -11700.0 -0.3 -0.8232 -0.8991 2555 SPBio_001231 CCOC(=O)NC1=C(C2CC2)C(=O)C(=C(C3CC3)C1=O)NC(=O)OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N14 compound treatment 218800.0 -23300.0 -0.62 248520.0 7940.0 0.2 -0.2975 -0.4546 694 SPBio_001232 C[C@H]1CC2C3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)C4(C)C=CC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N15 compound treatment 219960.0 -22200.0 -0.59 226760.0 -13800.0 -0.35 -0.6668 -0.9691 448 SPBio_001233 Clc1cccc(Cl)c1N=C2NCCN2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N16 compound treatment 210640.0 -31500.0 -0.84 245840.0 5260.0 0.13 -0.4995 -0.5872 742 SPBio_001234 C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]3(C)C2[C@H](O)C[C@H]4/C(=C(/CCC=C(C)C)\C(=O)O)/[C@H](C[C@@]43C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N17 compound treatment 214440.0 -27700.0 -0.74 238000.0 -2590.0 -0.07 -0.5688 -0.767 1204 SPBio_001235 CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)C(=O)N[C@]5(C)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C5=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N18 compound treatment 169400.0 -72700.0 -1.94 203920.0 -36700.0 -0.93 -2.0307 -0.9436 1261 SPBio_001236 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N19 compound treatment 219440.0 -22700.0 -0.61 245280.0 4700.0 0.12 -0.3436 -0.5569 3173761 SPBio_001237 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N20 compound treatment 226480.0 -15700.0 -0.42 232280.0 -8310.0 -0.21 -0.4446 -0.9501 1136 SPBio_001238 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)COC(=O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N21 compound treatment 210520.0 -31600.0 -0.84 214360.0 -26200.0 -0.67 -1.0677 -0.9932 924 SPBio_001239 NC(=N)NC(=N)Nc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N22 compound treatment 200760.0 -41400.0 -1.1 234400.0 -6190.0 -0.16 -0.8914 -0.7998 859 SPBio_001240 CC(=O)O[C@@]1(CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)C3CC[C@@]21C)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N23 mock treatment 229440.0 -12700.0 -0.34 225320.0 -15300.0 -0.39 -0.514 -0.9977 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 N24 mock treatment 219760.0 -22400.0 -0.6 243440.0 2860.0 0.07 -0.3707 -0.6166 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O01 mock treatment 255480.0 13300.0 0.36 247080.0 6500.0 0.17 0.3682 0.9392 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O02 mock treatment 241680.0 -464.0 -0.01 236760.0 -3830.0 -0.1 -0.0775 -0.7907 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O03 compound treatment 231840.0 -10300.0 -0.27 212000.0 -28600.0 -0.73 -0.7082 -0.9115 3172851 SPBio_001241 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O04 compound treatment 215520.0 -26600.0 -0.71 277040.0 36500.0 0.93 0.1535 0.1315 52159 SPBio_001242 COc1ccc2[nH]cc(CCN)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O05 compound treatment 223040.0 -19100.0 -0.51 330400.0 89800.0 2.28 1.2546 0.5362 3059213 SPBio_001243 COc1ccc(C(=O)c2ccccc2O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O06 compound treatment 145520.0 -96600.0 -2.58 147680.0 -92900.0 -2.36 -3.4921 -0.9991 1009556 SPBio_001244 Nc1c2ccccc2nc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O07 compound treatment 188640.0 -53500.0 -1.43 241040.0 455.0 0.01 -1.0006 -0.7013 1112 SPBio_001245 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O08 compound treatment 14680.0 -227000.0 -6.06 19040.0 -222000.0 -5.63 -8.2717 -0.9993 2060287 SPBio_001246 Cc1c(O)c(O)cc2c1CC=C3[C@@]2(C)CC[C@@]4(C)C5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O09 compound treatment 181880.0 -60300.0 -1.61 273680.0 33100.0 0.84 -0.5412 -0.2984 3058535 SPBio_001247 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O10 compound treatment 201400.0 -40700.0 -1.09 262120.0 21500.0 0.55 -0.381 -0.3132 3044526 SPBio_001248 NC(=N)N/N=C\c1c(Cl)cccc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O11 compound treatment 233240.0 -8900.0 -0.24 262240.0 21700.0 0.55 0.2215 0.3693 3177453 SPBio_001249 CC(=O)OCC(=O)[C@]12OC(C)(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]31C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O12 compound treatment 167640.0 -74500.0 -1.99 179800.0 -60800.0 -1.55 -2.4975 -0.9923 825 SPBio_001250 CC(Cc1ccc(O)c(O)c1)(NN)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O13 compound treatment 213520.0 -28600.0 -0.76 254000.0 13400.0 0.34 -0.2985 -0.357 3045799 SPBio_001251 NC(=Nc1nc(CSCC/C(=N\S(=O)(=O)N)/N)cs1)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O14 compound treatment 254240.0 12100.0 0.32 254000.0 13400.0 0.34 0.4692 0.9996 3173079 SPBio_001252 CC1(C)N[C@@H](C(=O)N1C2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O15 compound treatment 228360.0 -13800.0 -0.37 257600.0 17000.0 0.43 0.046 0.0811 1509 SPBio_001253 Cn1c(COC(=O)N)ncc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O16 compound treatment 205280.0 -36900.0 -0.98 263440.0 22900.0 0.58 -0.2841 -0.2488 2060386 SPBio_001254 CCN1C[C@]2(C)CC[C@H](OC)[C@@]34C2[C@H](O)[C@]5(OCO[C@]65C[C@H](OC)[C@H]7C[C@]4(O)C6[C@H]7O)C13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O17 compound treatment 202480.0 -39700.0 -1.06 291720.0 51100.0 1.3 0.1716 0.1024 1443 SPBio_001255 CN(C)CCOC(c1ccccc1)c2ccccc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O18 compound treatment 197440.0 -44700.0 -1.19 265200.0 24600.0 0.63 -0.4003 -0.2973 2857 SPBio_001256 O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O19 compound treatment 216040.0 -26100.0 -0.7 245440.0 4860.0 0.12 -0.4049 -0.5728 719 SPBio_001257 CN(CC#C)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O20 compound treatment 202280.0 -39900.0 -1.06 220160.0 -20400.0 -0.52 -1.1188 -0.9457 3198424 SPBio_001258 CN(C)CCCN1C(=C(C)Sc2ccccc12)/C=C(\C=C)/C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O21 compound treatment 254720.0 12600.0 0.34 262640.0 22100.0 0.56 0.6336 0.9698 931 SPBio_001259 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O22 compound treatment 272480.0 30300.0 0.81 250320.0 9740.0 0.25 0.747 0.8831 3059817 SPBio_001260 CCCCC(=O)N(Cc1ccc(cc1)c2ccccc2c3nn[nH]n3)[C@@H](C(C)C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O23 mock treatment 243600.0 1460.0 0.04 256400.0 15800.0 0.4 0.3118 0.7718 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 O24 mock treatment 262440.0 20300.0 0.54 267880.0 27300.0 0.69 0.8734 0.9924 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P01 mock treatment 241800.0 -344.0 -0.01 223600.0 -17000.0 -0.43 -0.3119 -0.722 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P02 mock treatment 255800.0 13700.0 0.36 257400.0 16800.0 0.43 0.5598 0.9968 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P03 compound treatment 221160.0 -21000.0 -0.56 239600.0 -985.0 -0.03 -0.4133 -0.738 1213 SPBio_001261 CNCCc1ccccn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P04 compound treatment 214240.0 -27900.0 -0.74 225320.0 -15300.0 -0.39 -0.8005 -0.954 3198429 SPBio_001262 CC(=O)O[C@@]1(CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P05 compound treatment 146280.0 -95900.0 -2.56 270160.0 29600.0 0.75 -1.2756 -0.4788 749 SPBio_001263 NC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P06 compound treatment 211680.0 -30500.0 -0.81 256520.0 15900.0 0.41 -0.2879 -0.3171 1062 SPBio_001264 COc1ccccc1OCC(O)COC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P07 compound treatment 219040.0 -23100.0 -0.62 296160.0 55600.0 1.41 0.5636 0.3656 1119 SPBio_001265 CSCCC(NC=O)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P08 compound treatment 223680.0 -18500.0 -0.49 282360.0 41800.0 1.06 0.403 0.3442 842 SPBio_001266 Cn1cc[nH]c1=S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P09 compound treatment 40600.0 -202000.0 -5.37 100560.0 -140000.0 -3.56 -6.3173 -0.98 449 SPBio_001267 CC1=CC(=O)c2ccccc2C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P10 compound treatment 203040.0 -39100.0 -1.04 285360.0 44800.0 1.14 0.0678 0.0439 1234 SPBio_001268 C[C@H]1CC2C3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P11 compound treatment 224280.0 -17900.0 -0.48 262160.0 21600.0 0.55 0.0511 0.0703 1464728 SPBio_001269 Cn1c(=O)[nH]c2nc[nH]c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P12 compound treatment 288800.0 46700.0 1.24 292360.0 51800.0 1.32 1.8105 0.9996 3045140 SPBio_001270 CC(C)[N+]1(C)C2CC[C@@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P13 compound treatment 255680.0 13500.0 0.36 266640.0 26100.0 0.66 0.7236 0.9592 925 SPBio_001271 C[C@@H]([C@H](O)c1ccccc1)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P14 compound treatment 219960.0 -22200.0 -0.59 267640.0 27100.0 0.69 0.0682 0.0752 1321 SPBio_001272 Cc1cc(=O)[nH]c(=S)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P15 compound treatment 222080.0 -20100.0 -0.53 366320.0 126000.0 3.2 1.8823 0.5807 1492782 SPBio_001273 OCNC(=O)c1cccnc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P16 compound treatment 208760.0 -33400.0 -0.89 290560.0 50000.0 1.27 0.2691 0.1735 884 SPBio_001274 CN(C)CCC(c1ccccc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P17 compound treatment 213680.0 -28500.0 -0.76 310600.0 70000.0 1.78 0.7222 0.3732 771 SPBio_001275 CN1CCC(=C2c3ccsc3C(=O)Cc4ccccc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P18 compound treatment 190640.0 -51500.0 -1.37 256440.0 15900.0 0.4 -0.686 -0.4793 822 SPBio_001276 CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P19 compound treatment 45280.0 -197000.0 -5.25 122040.0 -119000.0 -3.01 -5.8429 -0.9653 1130 SPBio_001277 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P20 compound treatment 10800.0 -231000.0 -6.17 13200.0 -227000.0 -5.78 -8.4498 -0.9995 1511 SPBio_001278 Oc1ccc(cc1)C2(OC(=O)c3ccccc32)c4ccc(O)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P21 compound treatment 266840.0 24700.0 0.66 256040.0 15500.0 0.39 0.7435 0.9696 752 SPBio_001279 CC1CCc2cc(F)cc3c(=O)c(cn1c23)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P22 compound treatment 245560.0 3420.0 0.09 244600.0 4020.0 0.1 0.1366 0.9984 1208 SPBio_001280 CNC[C@H](O)c1cccc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P23 mock treatment 244880.0 2740.0 0.07 227640.0 -12900.0 -0.33 -0.1812 -0.5374 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2161 P24 mock treatment 249800.0 7660.0 0.2 224600.0 -16000.0 -0.41 -0.1431 -0.3146 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A01 mock treatment 245600.0 9530.0 0.25 225920.0 -6200.0 -0.16 0.0682 0.2282 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A02 mock treatment 235480.0 -592.0 -0.02 239280.0 7160.0 0.18 0.1176 0.6434 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A03 compound treatment 222040.0 -14000.0 -0.37 228360.0 -3760.0 -0.1 -0.3321 -0.86 1126 SPBio_001281 O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A04 compound treatment 229080.0 -6990.0 -0.19 232440.0 324.0 0.01 -0.126 -0.6752 1065 SPBio_001282 CN1C(CC(O)c2ccccc2)CCCC1CC(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A05 compound treatment 198280.0 -37800.0 -1.01 218880.0 -13200.0 -0.34 -0.9505 -0.8947 968 SPBio_001283 CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A06 compound treatment 214800.0 -21300.0 -0.57 196720.0 -35400.0 -0.9 -1.0375 -0.9752 802 SPBio_001284 Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A07 compound treatment 194880.0 -41200.0 -1.1 198080.0 -34000.0 -0.87 -1.3886 -0.993 976 SPBio_001285 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A08 compound treatment 180840.0 -55200.0 -1.47 205640.0 -26500.0 -0.67 -1.5173 -0.9371 1284 SPBio_001286 OC(=O)CN(CC(=O)O)Cc1cc2c(c3ccccc3C(=O)O)c4cc(CN(CC(=O)O)CC(=O)O)c(=O)cc4oc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A09 compound treatment 200160.0 -35900.0 -0.96 240000.0 7880.0 0.2 -0.5353 -0.5472 992 SPBio_001287 CC[C@H]1[C@@H](Cc2cncn2C)COC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A10 compound treatment 218640.0 -17400.0 -0.46 244960.0 12800.0 0.33 -0.0977 -0.1721 686 SPBio_001288 C(Nc1ncnc2[nH]cnc12)c3ccco3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A11 compound treatment 220360.0 -15700.0 -0.42 243720.0 11600.0 0.3 -0.0876 -0.171 1428 SPBio_001289 CC(C)NCC(O)COc1cccc2[nH]ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A12 compound treatment 234280.0 -1790.0 -0.05 251160.0 19000.0 0.48 0.3086 0.6342 3058615 SPBio_001290 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A13 compound treatment 232520.0 -3550.0 -0.09 240520.0 8400.0 0.21 0.0841 0.3599 3173725 SPBio_001291 CCN1CCN(C(=O)NC(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4)C(=O)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A14 compound treatment 202320.0 -33800.0 -0.9 233280.0 1160.0 0.03 -0.6154 -0.6835 2069337 SPBio_001292 COC(=O)C(C)c1ccc(cc1)C(=O)c2cccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A15 compound treatment 225920.0 -10200.0 -0.27 225080.0 -7040.0 -0.18 -0.3179 -0.9798 347 SPBio_001293 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A16 compound treatment 217920.0 -18200.0 -0.48 244360.0 12200.0 0.31 -0.1221 -0.2122 1606 SPBio_001294 NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A17 compound treatment 191800.0 -44300.0 -1.18 240000.0 7880.0 0.2 -0.6929 -0.5787 1000106 SPBio_001295 O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A18 compound treatment 224440.0 -11600.0 -0.31 255080.0 23000.0 0.58 0.1936 0.2928 2060333 SPBio_001296 COc1ccc(/C=C/c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A19 compound treatment 212040.0 -24000.0 -0.64 223800.0 -8320.0 -0.21 -0.6026 -0.8931 349 SPBio_001297 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A20 compound treatment 40640.0 -195000.0 -5.21 87760.0 -144000.0 -3.67 -6.28 -0.9853 3054675 SPBio_001298 CC(C)CCCC(C)C1CCC2/C(=C/C=C\3/C[C@@H](O)CCC3=C)/CCCC12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A21 compound treatment 245000.0 8930.0 0.24 234520.0 2400.0 0.06 0.2115 0.8608 1289 SPBio_001299 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)C=C[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A22 compound treatment 217920.0 -18200.0 -0.48 243960.0 11800.0 0.3 -0.1293 -0.2268 2060331 SPBio_001300 CC1=CCC(=C)[C@H]2CC(C)(C)[C@@H]2CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A23 mock treatment 228280.0 -7790.0 -0.21 247240.0 15100.0 0.38 0.125 0.286 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 A24 mock treatment 244840.0 8770.0 0.23 261120.0 29000.0 0.74 0.6868 0.8877 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B01 mock treatment 244120.0 8050.0 0.21 262840.0 30700.0 0.78 0.7041 0.8691 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B02 mock treatment 229440.0 -6630.0 -0.18 235480.0 3360.0 0.09 -0.0646 -0.3287 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B03 compound treatment 14560.0 -222000.0 -5.91 15160.0 -217000.0 -5.52 -8.0769 -0.9994 1531 SPBio_001301 O=c1n([se]c2ccccc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B04 compound treatment 210560.0 -25500.0 -0.68 219200.0 -12900.0 -0.33 -0.7132 -0.9442 1339 SPBio_001302 CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B05 compound treatment 14320.0 -222000.0 -5.91 15440.0 -217000.0 -5.51 -8.0764 -0.9994 1168 SPBio_001303 CC12CCC3C(CCc4cc(OCc5ccccc5)ccc34)C2C[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B06 compound treatment 209920.0 -26200.0 -0.7 250600.0 18500.0 0.47 -0.1607 -0.1911 691 SPBio_001304 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2C1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B07 compound treatment 52400.0 -184000.0 -4.9 87760.0 -144000.0 -3.67 -6.0582 -0.9899 2060367 SPBio_001305 CS(=O)(=O)CCCCN=C=S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B08 compound treatment 204880.0 -31200.0 -0.83 250120.0 18000.0 0.46 -0.2644 -0.2785 3173981 SPBio_001306 CCOC(=O)OC(C)OC(=O)C1N2C(SC1(C)C)C(NC(=O)[C@H](N)c3ccccc3)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B09 compound treatment 197200.0 -38900.0 -1.04 236760.0 4640.0 0.12 -0.6494 -0.6225 902 SPBio_001307 OC(=O)c1cc2cc(Cc3cccnc3)ccc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B10 compound treatment 216120.0 -20000.0 -0.53 237160.0 5040.0 0.13 -0.2855 -0.5217 917 SPBio_001308 NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B11 compound treatment 227720.0 -8350.0 -0.22 240560.0 8440.0 0.21 -0.0057 -0.0183 1045 SPBio_001309 C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B12 compound treatment 230880.0 -5190.0 -0.14 231960.0 -156.0 0.0 -0.1007 -0.7271 841 SPBio_001310 C/C(=C(/CCOP(=O)(O)O)\SC(=O)c1ccccc1)/N(Cc2cnc(C)nc2N)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B13 compound treatment 115800.0 -120000.0 -3.21 138280.0 -93800.0 -2.39 -3.9546 -0.9894 1258696 SPBio_001311 Cc1c(Cl)cccc1Nc2ccccc2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B14 compound treatment 101160.0 -135000.0 -3.6 114200.0 -118000.0 -3.0 -4.6636 -0.9959 1082 SPBio_001312 CN(Cc1cc(Br)cc(Br)c1N)C2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B15 compound treatment 225320.0 -10800.0 -0.29 237040.0 4920.0 0.13 -0.1142 -0.365 1196 SPBio_001313 CCCOc1ccccc1c2nc3[nH]nnc3c(=O)[nH]2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B16 compound treatment 206360.0 -29700.0 -0.79 221680.0 -10400.0 -0.27 -0.7478 -0.8951 955 SPBio_001314 CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B17 compound treatment 198320.0 -37800.0 -1.01 215280.0 -16800.0 -0.43 -1.0145 -0.9274 1076 SPBio_001315 Cc1cccc(C)c1NC2=NCCCS2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B18 compound treatment 203480.0 -32600.0 -0.87 228360.0 -3760.0 -0.1 -0.682 -0.7801 1000338 SPBio_001316 NC[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B19 compound treatment 209880.0 -26200.0 -0.7 234440.0 2320.0 0.06 -0.452 -0.645 196 SPBio_001317 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B20 compound treatment 232120.0 -3950.0 -0.11 226120.0 -6000.0 -0.15 -0.1823 -0.9837 2359 SPBio_001318 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@@H]32)n1c5ccccc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B21 compound treatment 149440.0 -86600.0 -2.31 225040.0 -7080.0 -0.18 -1.7605 -0.7599 1000121 SPBio_001319 C/C(=C\CO)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B22 compound treatment 50160.0 -186000.0 -4.96 91280.0 -141000.0 -3.58 -6.0372 -0.9873 755 SPBio_001320 CC(CN(C)C)CN1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B23 mock treatment 257840.0 21800.0 0.58 270880.0 38800.0 0.99 1.1073 0.9681 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 B24 mock treatment 248200.0 12100.0 0.32 247560.0 15400.0 0.39 0.5063 0.9953 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C01 mock treatment 230200.0 -5870.0 -0.16 241720.0 9600.0 0.24 0.062 0.2136 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C02 mock treatment 225960.0 -10100.0 -0.27 220440.0 -11700.0 -0.3 -0.4006 -0.9988 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C03 compound treatment 206120.0 -30000.0 -0.8 233600.0 1480.0 0.04 -0.538 -0.673 1455 SPBio_001321 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C04 compound treatment 214200.0 -21900.0 -0.58 222600.0 -9520.0 -0.24 -0.5835 -0.9241 1031375 SPBio_001322 NC(CCCNC(=O)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C05 compound treatment 209760.0 -26300.0 -0.7 227280.0 -4840.0 -0.12 -0.583 -0.8186 1273 SPBio_001323 C[C@@]12CC(=O)C3C(CCC4=CC(=O)C=C[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C06 compound treatment 207280.0 -28800.0 -0.77 234280.0 2160.0 0.06 -0.5039 -0.6548 3054270 SPBio_001324 COC(=O)[C@@H]1C(O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C07 compound treatment 212800.0 -23300.0 -0.62 215760.0 -16400.0 -0.42 -0.7328 -0.9811 962 SPBio_001325 CCC1(C(=O)NCNC1=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C08 compound treatment 77000.0 -159000.0 -4.24 186760.0 -45400.0 -1.15 -3.8145 -0.8679 2060265 SPBio_001326 COC(=O)CCC(C)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C09 compound treatment 206160.0 -29900.0 -0.8 217800.0 -14300.0 -0.36 -0.8213 -0.9369 722 SPBio_001327 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C10 compound treatment 16040.0 -220000.0 -5.87 21880.0 -210000.0 -5.35 -7.9282 -0.9989 2060267 SPBio_001328 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C11 compound treatment 223200.0 -12900.0 -0.34 234160.0 2040.0 0.05 -0.2059 -0.5933 2431 SPBio_001329 CCN(CC)CCNC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C12 compound treatment 230560.0 -5510.0 -0.15 243160.0 11000.0 0.28 0.0946 0.2986 3177457 SPBio_001330 CC(CCC(=O)O)[C@H]1CCC2C3C(CC(=O)[C@]12C)[C@@]4(C)CCC(=O)C[C@H]4CC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C13 compound treatment 215280.0 -20800.0 -0.55 220760.0 -11400.0 -0.29 -0.5962 -0.9538 779 SPBio_001331 CCN(CC)CCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C14 compound treatment 24560.0 -212000.0 -5.64 33640.0 -198000.0 -5.05 -7.5562 -0.9985 3174369 SPBio_001332 C[C@H]1OC(C[C@H](O)C1O)O[C@@H]2[C@@H](C)OC(C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6C5CC[C@]7(C)[C@H]([C@@H](O)C[C@]67O)C8=CC(=O)OC8)C4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C15 compound treatment 15840.0 -220000.0 -5.87 22120.0 -210000.0 -5.34 -7.9277 -0.9989 1041 SPBio_001333 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C16 compound treatment 213880.0 -22200.0 -0.59 234440.0 2320.0 0.06 -0.3766 -0.6333 2880 SPBio_001334 N[C@@H](CCC(=O)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C17 compound treatment 203920.0 -32200.0 -0.86 224320.0 -7800.0 -0.2 -0.7463 -0.8482 1057 SPBio_001335 OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C18 compound treatment 203600.0 -32500.0 -0.87 222600.0 -9520.0 -0.24 -0.7833 -0.8713 2060276 SPBio_001336 C[C@@H]1C(=O)OC2[C@H](O)C34[C@@H]5OC(=O)[C@@]4(O[C@@H]6OC(=O)[C@H](O)[C@@]63[C@@H]([C@H]5O)C(C)(C)C)[C@@]12O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C19 compound treatment 53800.0 -182000.0 -4.86 100040.0 -132000.0 -3.36 -5.8111 -0.9837 1000117 SPBio_001337 CC(=O)[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C20 compound treatment 198680.0 -37400.0 -1.0 224040.0 -8080.0 -0.21 -0.8502 -0.8352 1275107 SPBio_001338 C1Cc2c(CN1)[nH]c3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C21 compound treatment 206960.0 -29100.0 -0.78 232360.0 244.0 0.01 -0.5445 -0.7014 1397 SPBio_001339 CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C22 compound treatment 203480.0 -32600.0 -0.87 210880.0 -21200.0 -0.54 -0.9963 -0.9738 2060253 SPBio_001340 NC(CC(=O)c1ccccc1N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C23 mock treatment 221320.0 -14800.0 -0.39 215400.0 -16700.0 -0.43 -0.5787 -0.9993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 C24 mock treatment 229840.0 -6230.0 -0.17 224120.0 -8000.0 -0.2 -0.2613 -0.995 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D01 mock treatment 224640.0 -11400.0 -0.3 234800.0 2680.0 0.07 -0.1673 -0.5355 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D02 mock treatment 206640.0 -29400.0 -0.78 221800.0 -10300.0 -0.26 -0.7404 -0.8948 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D03 compound treatment 122960.0 -113000.0 -3.02 140360.0 -91800.0 -2.33 -3.7822 -0.992 1205 SPBio_001341 CC(=CCC1=C(O)C(=O)c2ccccc2C1=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D04 compound treatment 201280.0 -34800.0 -0.93 242440.0 10300.0 0.26 -0.4703 -0.4879 1385 SPBio_001342 C(/C=C/N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D05 compound treatment 26840.0 -209000.0 -5.58 32560.0 -200000.0 -5.07 -7.5326 -0.9989 1277 SPBio_001343 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(=O)C)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)C(CCC7C6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D06 compound treatment 207520.0 -28600.0 -0.76 228320.0 -3800.0 -0.1 -0.6066 -0.7904 1442 SPBio_001344 CC(=O)NC1SCCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D07 compound treatment 16480.0 -220000.0 -5.85 23720.0 -208000.0 -5.3 -7.8868 -0.9988 3172730 SPBio_001345 OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D08 compound treatment 14280.0 -222000.0 -5.91 18080.0 -214000.0 -5.44 -8.0297 -0.9991 1054 SPBio_001346 CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D09 compound treatment 233480.0 -2590.0 -0.07 234440.0 2320.0 0.06 -0.0071 -0.078 1009973 SPBio_001347 OC(C(O)C(O)C(=O)O)C(O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D10 compound treatment 153520.0 -82600.0 -2.2 201400.0 -30700.0 -0.78 -2.1086 -0.9029 716 SPBio_001348 CN(C)CCC=C1c2ccccc2C=Cc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D11 compound treatment 221880.0 -14200.0 -0.38 224080.0 -8040.0 -0.2 -0.4121 -0.9582 1036 SPBio_001349 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D12 compound treatment 147920.0 -88200.0 -2.35 208720.0 -23400.0 -0.59 -2.0826 -0.859 1063 SPBio_001350 CC(CNCCc1ccc(O)c(O)c1)Cc2cccc(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D13 compound treatment 244240.0 8170.0 0.22 229280.0 -2840.0 -0.07 0.103 0.449 1608 SPBio_001351 NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D14 compound treatment 224800.0 -11300.0 -0.3 228200.0 -3920.0 -0.1 -0.2829 -0.8936 1507 SPBio_001352 CC(N)CCCC(C)(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D15 compound treatment 167320.0 -68800.0 -1.83 184640.0 -47500.0 -1.21 -2.1498 -0.9795 769 SPBio_001353 CCCCOc1ccc(CC(=O)NO)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D16 compound treatment 215040.0 -21000.0 -0.56 241480.0 9360.0 0.24 -0.2282 -0.3745 766 SPBio_001354 CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D17 compound treatment 225040.0 -11000.0 -0.29 236080.0 3960.0 0.1 -0.1367 -0.4397 717 SPBio_001355 OC(=O)c1ccccc1OP(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D18 compound treatment 148640.0 -87400.0 -2.33 179960.0 -52200.0 -1.33 -2.5861 -0.9643 1348 SPBio_001356 Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D19 compound treatment 212040.0 -24000.0 -0.64 241920.0 9800.0 0.25 -0.2768 -0.4026 1117 SPBio_001357 Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cnc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D20 compound treatment 15880.0 -220000.0 -5.87 16120.0 -216000.0 -5.49 -8.0348 -0.9994 1158 SPBio_001358 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D21 compound treatment 19360.0 -217000.0 -5.78 29920.0 -202000.0 -5.14 -7.7211 -0.9983 3079211 SPBio_001359 COC(=O)[C@]1(C)CCC[C@@]2(C)C1CC(=O)c3cc(ccc32)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D22 compound treatment 202080.0 -34000.0 -0.91 219600.0 -12500.0 -0.32 -0.8659 -0.9014 3046112 SPBio_001360 CC1(C)O[C@@H]2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)[C@@]2(O1)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D23 mock treatment 209880.0 -26200.0 -0.7 235160.0 3040.0 0.08 -0.4391 -0.6249 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 D24 mock treatment 231520.0 -4550.0 -0.12 206760.0 -25400.0 -0.64 -0.5417 -0.8257 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E01 mock treatment 213960.0 -22100.0 -0.59 253160.0 21000.0 0.54 -0.0385 -0.0484 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E02 mock treatment 214880.0 -21200.0 -0.57 233440.0 1320.0 0.03 -0.3757 -0.6638 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E03 compound treatment 262920.0 26800.0 0.72 249120.0 17000.0 0.43 0.8119 0.9708 351 SPBio_001361 CC(C)NCC(O)COc1cccc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E04 compound treatment 215840.0 -20200.0 -0.54 263960.0 31800.0 0.81 0.1911 0.1964 2069275 SPBio_001362 CC1(C)[C@H](CC[C@@]2(C)C1CC[C@@]3(C)C4CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC(=O)C32)C(=O)O)O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(=O)O)[C@H](O)[C@H]6O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E05 compound treatment 218480.0 -17600.0 -0.47 233000.0 884.0 0.02 -0.3158 -0.6725 912 SPBio_001363 CCCc1cc(=O)[nH]c(=S)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E06 compound treatment 45240.0 -191000.0 -5.09 48960.0 -183000.0 -4.66 -6.8908 -0.999 43 SPBio_001364 Fc1ccc(cc1)C(N2CCN(C/C=C/c3ccccc3)CC2)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E07 compound treatment 205640.0 -30400.0 -0.81 223240.0 -8880.0 -0.23 -0.7333 -0.8707 1000118 SPBio_001365 CN[C@@H](C)[C@@H](O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E08 compound treatment 210400.0 -25700.0 -0.68 261880.0 29800.0 0.76 0.0511 0.0501 936 SPBio_001366 OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E09 compound treatment 254840.0 18800.0 0.5 237480.0 5360.0 0.14 0.4503 0.8682 3173593 SPBio_001367 CN1CCCN=C1/C=C/c2cccs2.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E10 compound treatment 237400.0 1330.0 0.04 237440.0 5320.0 0.14 0.1207 0.863 837 SPBio_001368 CCOc1ccc2NC(C)(C)C=C(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E11 compound treatment 242440.0 6370.0 0.17 238680.0 6560.0 0.17 0.2381 1.0 889 SPBio_001369 NC(=O)c1cnccn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E12 compound treatment 154120.0 -82000.0 -2.19 219000.0 -13100.0 -0.33 -1.7809 -0.8057 852 SPBio_001370 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E13 compound treatment 224480.0 -11600.0 -0.31 234200.0 2080.0 0.05 -0.1811 -0.5775 830 SPBio_001371 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E14 compound treatment 238080.0 2010.0 0.05 223080.0 -9040.0 -0.23 -0.1246 -0.5282 764 SPBio_001372 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)n3c(=O)[nH]c4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E15 compound treatment 18640.0 -217000.0 -5.8 77240.0 -155000.0 -3.94 -6.8839 -0.9822 3174105 SPBio_001373 CN(C)c1ccc2[n+](C)c(/C=C/c3cc(C)n(c3C)c4ccccc4)ccc2c1.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E16 compound treatment 228920.0 -7150.0 -0.19 235520.0 3400.0 0.09 -0.0736 -0.3517 805 SPBio_001374 CCc1cccc2c3CCOC(CC)(CC(=O)O)c3[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E17 compound treatment 229800.0 -6270.0 -0.17 260560.0 28400.0 0.72 0.3931 0.5296 792 SPBio_001375 COc1ccc2nccc([C@@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E18 compound treatment 226280.0 -9790.0 -0.26 233040.0 924.0 0.02 -0.168 -0.6409 1033 SPBio_001376 CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E19 compound treatment 226120.0 -9950.0 -0.27 260400.0 28300.0 0.72 0.3209 0.4186 836 SPBio_001377 CNC(C)C(O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E20 compound treatment 213800.0 -22300.0 -0.59 240400.0 8280.0 0.21 -0.271 -0.4301 699 SPBio_001378 OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E21 compound treatment 229560.0 -6510.0 -0.17 227480.0 -4640.0 -0.12 -0.2061 -0.9822 711 SPBio_001379 Oc1cccc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E22 compound treatment 185160.0 -50900.0 -1.36 222960.0 -9160.0 -0.23 -1.1245 -0.8165 1172 SPBio_001380 CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E23 mock treatment 230840.0 -5230.0 -0.14 239120.0 7000.0 0.18 0.0273 0.1206 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 E24 mock treatment 217400.0 -18700.0 -0.5 224040.0 -8080.0 -0.21 -0.4972 -0.9233 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F01 mock treatment 228720.0 -7350.0 -0.2 263160.0 31000.0 0.79 0.4195 0.5158 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F02 mock treatment 240200.0 4130.0 0.11 259360.0 27200.0 0.69 0.5676 0.8093 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F03 compound treatment 217360.0 -18700.0 -0.5 297160.0 65000.0 1.65 0.8167 0.4727 3173633 SPBio_001381 CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(N)c3ccccc3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F04 compound treatment 198120.0 -38000.0 -1.01 304680.0 72600.0 1.85 0.5891 0.28 1298 SPBio_001382 CS(=O)(=O)Nc1ccc(cc1Oc2ccccc2)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F05 compound treatment 242320.0 6250.0 0.17 258360.0 26200.0 0.67 0.5896 0.8573 1067 SPBio_001383 CO[C@]1(NC(=O)CSCC#N)C2SCC(=C(N2C1=O)C(=O)O)CSc3nnnn3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F06 compound treatment 209840.0 -26200.0 -0.7 245120.0 13000.0 0.33 -0.2608 -0.3371 3045662 SPBio_001384 CC(N)C(O)c1cccc(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F07 compound treatment 229880.0 -6190.0 -0.17 245160.0 13000.0 0.33 0.1178 0.3179 3264 SPBio_001385 Cn1nnnc1SCC2=C(N3C(SC2)C(NC(=O)C(OC=O)c4ccccc4)C3=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F08 compound treatment 215720.0 -20400.0 -0.54 238320.0 6200.0 0.16 -0.2722 -0.4816 3069629 SPBio_001386 CC(=O)/N=c/1\sc(nn1C)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F09 compound treatment 243120.0 7050.0 0.19 219560.0 -12600.0 -0.32 -0.0929 -0.2507 1323 SPBio_001387 CC1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F10 compound treatment 19720.0 -216000.0 -5.77 23840.0 -208000.0 -5.3 -7.8236 -0.9991 1286 SPBio_001388 Cc1cc(ccc1OCCOCC[N+](C)(C)Cc2ccccc2)C(C)(C)CC(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F11 compound treatment 241360.0 5290.0 0.14 291480.0 59400.0 1.51 1.167 0.7698 1129 SPBio_001389 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F12 compound treatment 258160.0 22100.0 0.59 267040.0 34900.0 0.89 1.0443 0.9801 1535 SPBio_001390 COc1ccc(OC)c(c1)C(O)CNC(=O)CN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F13 compound treatment 245520.0 9450.0 0.25 281800.0 49700.0 1.26 1.0714 0.8317 2294 SPBio_001391 CC(=O)NC(C(=O)O)C(C)(C)SN=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F14 compound treatment 252120.0 16000.0 0.43 248400.0 16300.0 0.41 0.5953 0.9999 1055 SPBio_001392 CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F15 compound treatment 234600.0 -1470.0 -0.04 234560.0 2440.0 0.06 0.0162 0.2201 366 SPBio_001393 OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F16 compound treatment 228640.0 -7430.0 -0.2 235640.0 3520.0 0.09 -0.0768 -0.353 1163 SPBio_001394 Oc1ccc2C[C@H]3N(CC4CC4)CCC5([C@H]6Oc1c25)[C@@]3(O)CCC6=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F17 compound treatment 222960.0 -13100.0 -0.35 239600.0 7480.0 0.19 -0.1127 -0.283 1591 SPBio_001395 CC(C)C[C@@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F18 compound treatment 242320.0 6250.0 0.17 232400.0 284.0 0.01 0.1229 0.737 1386 SPBio_001396 CN1CC(c2ccccc2)c3cccc(N)c3C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F19 compound treatment 219640.0 -16400.0 -0.44 283800.0 51700.0 1.31 0.6194 0.4472 348755 SPBio_001397 OC(=O)c1cc2cc(F)ccc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F20 compound treatment 240680.0 4610.0 0.12 248160.0 16000.0 0.41 0.3753 0.881 1436 SPBio_001398 CCCNC(C)C(=O)Nc1ccccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F21 compound treatment 223200.0 -12900.0 -0.34 257840.0 25700.0 0.65 0.2198 0.2976 873168 SPBio_001399 OC(=O)c1cc(O)c2ccc(Cl)cc2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F22 compound treatment 234680.0 -1390.0 -0.04 219560.0 -12600.0 -0.32 -0.252 -0.784 3480197 SPBio_001400 CCC(NC(C)C)C(O)c1ccc(O)c2[nH]c(=O)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F23 mock treatment 231560.0 -4510.0 -0.12 220240.0 -11900.0 -0.3 -0.2986 -0.9186 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 F24 mock treatment 227000.0 -9070.0 -0.24 219040.0 -13100.0 -0.33 -0.4061 -0.9878 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G01 mock treatment 229080.0 -6990.0 -0.19 219440.0 -12700.0 -0.32 -0.3597 -0.9661 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G02 mock treatment 212080.0 -24000.0 -0.64 247160.0 15000.0 0.38 -0.1819 -0.244 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G03 compound treatment 220280.0 -15800.0 -0.42 253840.0 21700.0 0.55 0.0928 0.1337 1264 SPBio_001401 OCc1ccccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G04 compound treatment 216800.0 -19300.0 -0.51 253440.0 21300.0 0.54 0.02 0.0268 1438 SPBio_001402 CC(C(=O)O)c1cccc(Oc2ccccc2)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G05 compound treatment 236480.0 408.0 0.01 255760.0 23600.0 0.6 0.4328 0.7198 1447 SPBio_001403 NC(=O)c1ccccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G06 compound treatment 17600.0 -218000.0 -5.83 19240.0 -213000.0 -5.41 -7.9463 -0.9993 1036721 SPBio_001404 Oc1c(oc2ccccc2c1=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G07 compound treatment 220640.0 -15400.0 -0.41 219400.0 -12700.0 -0.32 -0.5196 -0.9929 933 SPBio_001405 CN1C2C[C@@H](C[C@H]1[C@H]3OC32)OC(=O)[C@H](CO)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G08 compound treatment 215640.0 -20400.0 -0.54 232800.0 684.0 0.02 -0.3729 -0.6842 3100 SPBio_001406 COc1c2OCOc2cc3CCN(C)Cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G09 compound treatment 225800.0 -10300.0 -0.27 236000.0 3880.0 0.1 -0.1238 -0.4254 3174107 SPBio_001407 CN[C@@H]1C(O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(=CC[C@H]3N)CN)[C@@H]2O)OC[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G10 compound treatment 236000.0 -72.4 0.0 241640.0 9520.0 0.24 0.1699 0.7014 802058 SPBio_001408 COc1cc(/C=C/C(=O)O)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G11 compound treatment 254200.0 18100.0 0.48 245800.0 13700.0 0.35 0.5878 0.987 795 SPBio_001409 CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G12 compound treatment 240480.0 4410.0 0.12 254720.0 22600.0 0.57 0.4895 0.8344 3173760 SPBio_001410 COc1cc2CCN(C)[C@@H]3Cc4cccc(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)c(O)c5)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G13 compound treatment 242880.0 6810.0 0.18 216880.0 -15200.0 -0.39 -0.1456 -0.3403 3059108 SPBio_001411 CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)C13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G14 compound treatment 224960.0 -11100.0 -0.3 214480.0 -17600.0 -0.45 -0.5266 -0.9798 1144 SPBio_001412 O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G15 compound treatment 241280.0 5210.0 0.14 268000.0 35900.0 0.91 0.7433 0.8054 1155 SPBio_001413 Nc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G16 compound treatment 169520.0 -66600.0 -1.77 241240.0 9120.0 0.23 -1.0907 -0.6095 2081691 SPBio_001414 CC(=CCC/C(=C/CC/C(=C/CO)/C)/C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G17 compound treatment 226280.0 -9790.0 -0.26 245800.0 13700.0 0.35 0.0614 0.1412 878 SPBio_001415 CC(=O)NS(=O)(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G18 compound treatment 235200.0 -872.0 -0.02 273040.0 40900.0 1.04 0.7193 0.6911 1203 SPBio_001416 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G19 compound treatment 211640.0 -24400.0 -0.65 230320.0 -1800.0 -0.05 -0.4929 -0.7548 1159 SPBio_001417 Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G20 compound treatment 206600.0 -29500.0 -0.79 222080.0 -10000.0 -0.26 -0.7361 -0.8909 1346 SPBio_001418 CCN(CC)CCNC(=O)COc1ccc(OC)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G21 compound treatment 213880.0 -22200.0 -0.59 232320.0 204.0 0.01 -0.4147 -0.7009 1177 SPBio_001419 Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G22 compound treatment 229920.0 -6150.0 -0.16 221360.0 -10800.0 -0.27 -0.3094 -0.9701 1210 SPBio_001420 CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G23 mock treatment 231000.0 -5070.0 -0.14 234160.0 2040.0 0.05 -0.0589 -0.4064 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 G24 mock treatment 223600.0 -12500.0 -0.33 207200.0 -24900.0 -0.63 -0.6831 -0.9547 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H01 mock treatment 243280.0 7210.0 0.19 232280.0 164.0 0.0 0.1388 0.7223 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H02 mock treatment 239160.0 3090.0 0.08 215240.0 -16900.0 -0.43 -0.2452 -0.5612 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H03 compound treatment 211800.0 -24300.0 -0.65 238240.0 6120.0 0.16 -0.3475 -0.5221 1364 SPBio_001421 OC(=O)/C(=C/c1cccc(O)c1)/C#N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H04 compound treatment 219880.0 -16200.0 -0.43 249480.0 17400.0 0.44 0.0069 0.0112 3173855 SPBio_001422 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H05 compound treatment 17720.0 -218000.0 -5.82 21720.0 -210000.0 -5.35 -7.8994 -0.9991 829 SPBio_001423 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H06 compound treatment 240000.0 3930.0 0.1 260880.0 28800.0 0.73 0.5912 0.8002 1270 SPBio_001424 C[N+](C)(C)CCCCCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H07 compound treatment 222640.0 -13400.0 -0.36 214760.0 -17400.0 -0.44 -0.5653 -0.9946 3061087 SPBio_001425 NC/C=C/C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H08 compound treatment 247800.0 11700.0 0.31 227000.0 -5120.0 -0.13 0.1291 0.3813 1242 SPBio_001426 CN(CS(=O)(=O)O)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H09 compound treatment 220800.0 -15300.0 -0.41 237120.0 5000.0 0.13 -0.198 -0.464 3684 SPBio_001427 OC(=O)C1=CCCNC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H10 compound treatment 21040.0 -215000.0 -5.73 22080.0 -210000.0 -5.34 -7.8304 -0.9994 1342 SPBio_001428 CN(C)C(=S)SSC(=S)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H11 compound treatment 241760.0 5690.0 0.15 246520.0 14400.0 0.37 0.3662 0.9238 1923 SPBio_001429 NC1(CC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H12 compound treatment 251680.0 15600.0 0.42 251120.0 19000.0 0.48 0.6359 0.9972 3173628 SPBio_001430 CN1C(C)(C)CCCC1(C)C.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H13 compound treatment 276960.0 40900.0 1.09 235880.0 3760.0 0.1 0.8385 0.7662 1111718 SPBio_001431 NC1(CCC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H14 compound treatment 166040.0 -70000.0 -1.87 158560.0 -73600.0 -1.87 -2.6428 -1.0 758 SPBio_001432 CCCOc1ccc2nc(NC(=O)OC)[nH]c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H15 compound treatment 95920.0 -140000.0 -3.74 103680.0 -128000.0 -3.27 -4.9515 -0.9977 121 SPBio_001433 OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H16 compound treatment 214360.0 -21700.0 -0.58 206960.0 -25200.0 -0.64 -0.8616 -0.9988 1410 SPBio_001434 S=P(N1CC1)(N2CC2)N3CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H17 compound treatment 250000.0 13900.0 0.37 273080.0 41000.0 1.04 0.9991 0.9035 1594 SPBio_001435 N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H18 compound treatment 234560.0 -1510.0 -0.04 250640.0 18500.0 0.47 0.3045 0.6442 1080 SPBio_001436 N[C@H](Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H19 compound treatment 236000.0 -72.4 0.0 261680.0 29600.0 0.75 0.5302 0.7053 1458 SPBio_001437 NC(Cc1ccc(Cl)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H20 compound treatment 189040.0 -47000.0 -1.25 250040.0 17900.0 0.46 -0.5645 -0.4231 1528 SPBio_001438 NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H21 compound treatment 221320.0 -14800.0 -0.39 239120.0 7000.0 0.18 -0.1522 -0.3525 3198954 SPBio_001439 CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H22 compound treatment 19360.0 -217000.0 -5.78 22280.0 -210000.0 -5.34 -7.8584 -0.9992 846 SPBio_001440 Cc1nc2sccn2c(=O)c1CCN3CCC(=C(c4ccc(F)cc4)c5ccc(F)cc5)CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H23 mock treatment 229000.0 -7070.0 -0.19 237320.0 5200.0 0.13 -0.0398 -0.1727 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 H24 mock treatment 225120.0 -11000.0 -0.29 201840.0 -30300.0 -0.77 -0.7508 -0.9119 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I01 mock treatment 231600.0 -4470.0 -0.12 229080.0 -3040.0 -0.08 -0.1389 -0.9779 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I02 mock treatment 218520.0 -17600.0 -0.47 224880.0 -7240.0 -0.18 -0.461 -0.9168 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I03 compound treatment 215200.0 -20900.0 -0.56 220880.0 -11200.0 -0.29 -0.5955 -0.952 934 SPBio_001441 Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I04 compound treatment 149920.0 -86200.0 -2.3 148480.0 -83600.0 -2.13 -3.128 -0.9993 1350 SPBio_001442 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I05 compound treatment 215160.0 -20900.0 -0.56 232880.0 764.0 0.02 -0.3805 -0.6821 799 SPBio_001443 Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I06 compound treatment 30680.0 -205000.0 -5.48 32320.0 -200000.0 -5.08 -7.4645 -0.9993 1233 SPBio_001444 CO[C@@H]1[C@@H](O)[C@H](C)O[C@H](O[C@H]2CC[C@@]3(C=O)[C@H](CCC4C3CC[C@]5(C)[C@H](CC[C@]45O)C6=CC(=O)OC6)C2)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I07 compound treatment 222880.0 -13200.0 -0.35 250840.0 18700.0 0.48 0.0879 0.1485 867 SPBio_001445 Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I08 compound treatment 237280.0 1210.0 0.03 236320.0 4200.0 0.11 0.0983 0.881 3173860 SPBio_001446 O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5OC1[C@]2(CCN3CC6CCC6)c54 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I09 compound treatment 234560.0 -1510.0 -0.04 224360.0 -7760.0 -0.2 -0.168 -0.8344 753 SPBio_001447 O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I10 compound treatment 217600.0 -18500.0 -0.49 219880.0 -12200.0 -0.31 -0.5683 -0.9755 714 SPBio_001448 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc2ccc(OC)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I11 compound treatment 233280.0 -2790.0 -0.07 228160.0 -3960.0 -0.1 -0.1238 -0.989 1192 SPBio_001449 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I12 compound treatment 168680.0 -67400.0 -1.8 158720.0 -73400.0 -1.87 -2.5902 -0.9998 3174345 SPBio_001450 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N.OC(=O)c1cc(ccc1O)S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I13 compound treatment 243040.0 6970.0 0.19 222720.0 -9400.0 -0.24 -0.0376 -0.1242 1212 SPBio_001451 CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I14 compound treatment 236480.0 408.0 0.01 226720.0 -5400.0 -0.14 -0.0893 -0.6491 1291 SPBio_001452 CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I15 compound treatment 238240.0 2170.0 0.06 242960.0 10800.0 0.28 0.2358 0.8371 743 SPBio_001453 CC(C)(C)NCC(O)c1cc(O)cc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I16 compound treatment 253480.0 17400.0 0.46 223760.0 -8360.0 -0.21 0.178 0.3486 728 SPBio_001454 Cc1cc(nnc1NCCN2CCOCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I17 compound treatment 172840.0 -63200.0 -1.69 147240.0 -84900.0 -2.16 -2.7181 -0.9925 1218 SPBio_001455 CCCCNc1ccc(cc1)C(=O)OCCN(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I18 compound treatment 228000.0 -8070.0 -0.22 237480.0 5360.0 0.14 -0.0558 -0.2188 733 SPBio_001456 CC1(CC2CC3(C)C1)CC(N)(C2)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I19 compound treatment 258160.0 22100.0 0.59 248000.0 15900.0 0.4 0.702 0.9831 1418 SPBio_001457 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I20 compound treatment 209080.0 -27000.0 -0.72 239120.0 7000.0 0.18 -0.383 -0.5166 983 SPBio_001458 NCCCS(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I21 compound treatment 231040.0 -5030.0 -0.13 227000.0 -5120.0 -0.13 -0.1869 -0.9999 1444 SPBio_001459 C1CN=C(N1)C2CCCc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I22 compound treatment 206720.0 -29400.0 -0.78 218720.0 -13400.0 -0.34 -0.7942 -0.9305 840551 SPBio_001460 NCCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I23 mock treatment 207280.0 -28800.0 -0.77 233080.0 964.0 0.02 -0.5255 -0.6842 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 I24 mock treatment 234320.0 -1750.0 -0.05 203200.0 -28900.0 -0.74 -0.5529 -0.7505 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J01 mock treatment 249680.0 13600.0 0.36 240600.0 8480.0 0.22 0.4091 0.9692 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J02 mock treatment 235400.0 -672.0 -0.02 220080.0 -12000.0 -0.31 -0.2291 -0.7472 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J03 compound treatment 229800.0 -6270.0 -0.17 233280.0 1160.0 0.03 -0.0973 -0.5731 3471022 SPBio_001461 CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J04 compound treatment 243760.0 7690.0 0.2 254200.0 22100.0 0.56 0.542 0.9067 3173083 SPBio_001462 CO[C@H]1[C@H](O)CC(=O)O[C@@H](C)C/C=C/C=C/[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J05 compound treatment 131640.0 -104000.0 -2.78 130080.0 -102000.0 -2.59 -3.8034 -0.9994 1581 SPBio_001463 CNC(=N)NCCCC(N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J06 compound treatment 199640.0 -36400.0 -0.97 217880.0 -14200.0 -0.36 -0.9428 -0.9095 115 SPBio_001464 COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J07 compound treatment 229960.0 -6110.0 -0.16 215480.0 -16600.0 -0.42 -0.4143 -0.914 869 SPBio_001465 CCC1(C)CC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J08 compound treatment 234040.0 -2030.0 -0.05 243880.0 11800.0 0.3 0.1732 0.5697 839 SPBio_001466 Nc1nc2n(COCCO)cnc2c(=O)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J09 compound treatment 248560.0 12500.0 0.33 261160.0 29000.0 0.74 0.7576 0.9353 3172968 SPBio_001467 CCC1NC(=O)C(C(O)C(C)C/C=C/C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J10 compound treatment 238040.0 1970.0 0.05 240040.0 7920.0 0.2 0.1796 0.8625 897 SPBio_001468 CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J11 compound treatment 241080.0 5010.0 0.13 243440.0 11300.0 0.29 0.298 0.939 3173475 SPBio_001469 CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@@H]([C@H]3OC(=O)C)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](OC(=O)C)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J12 compound treatment 214600.0 -21500.0 -0.57 199840.0 -32300.0 -0.82 -0.9851 -0.9845 117 SPBio_001470 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J13 compound treatment 232800.0 -3270.0 -0.09 225160.0 -6960.0 -0.18 -0.1868 -0.947 3198430 SPBio_001471 CC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(F)(F)F)C(C)C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J14 compound treatment 21840.0 -214000.0 -5.71 20880.0 -211000.0 -5.37 -7.8369 -0.9995 1417 SPBio_001472 CCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J15 compound treatment 264360.0 28300.0 0.75 240400.0 8280.0 0.21 0.6823 0.8712 3079212 SPBio_001473 NCCCN.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J16 compound treatment 258120.0 22000.0 0.59 245040.0 12900.0 0.33 0.648 0.9622 757 SPBio_001474 OC(=O)c1cn(C2CC2)c3cc(N4CCNCC4)c(F)cc3c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J17 compound treatment 241320.0 5250.0 0.14 238480.0 6360.0 0.16 0.2134 0.9974 3198431 SPBio_001475 CC(C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J18 compound treatment 249320.0 13200.0 0.35 230880.0 -1240.0 -0.03 0.2275 0.6416 1038 SPBio_001476 O=C1CCCN1CC#CCN2CCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J19 compound treatment 226840.0 -9230.0 -0.25 227920.0 -4200.0 -0.11 -0.2495 -0.93 1095029 SPBio_001477 CCCCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J20 compound treatment 183920.0 -52200.0 -1.39 210800.0 -21300.0 -0.54 -1.3665 -0.9156 382 SPBio_001478 NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J21 compound treatment 214920.0 -21200.0 -0.56 226680.0 -5440.0 -0.14 -0.4965 -0.8551 3079213 SPBio_001479 N[C@@H](CCC(=O)N[C@@H](CCSC(CC(=O)O)C(=O)O)C(=O)NCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J22 compound treatment 212160.0 -23900.0 -0.64 221760.0 -10400.0 -0.26 -0.637 -0.9235 1512 SPBio_001480 CC(C)NCC(O)c1ccc2ccccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J23 mock treatment 219240.0 -16800.0 -0.45 229040.0 -3080.0 -0.08 -0.3727 -0.818 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 J24 mock treatment 231720.0 -4350.0 -0.12 232280.0 164.0 0.0 -0.0791 -0.6813 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K01 mock treatment 281720.0 45600.0 1.22 193440.0 -38700.0 -0.98 0.1652 0.1056 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K02 mock treatment 232960.0 -3110.0 -0.08 335480.0 103000.0 2.63 1.7997 0.6844 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K03 compound treatment 230120.0 -5950.0 -0.16 204600.0 -27500.0 -0.7 -0.6069 -0.846 737 SPBio_001481 c1nc(cs1)c2nc3ccccc3[nH]2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K04 compound treatment 225600.0 -10500.0 -0.28 237120.0 5000.0 0.13 -0.1075 -0.3503 723 SPBio_001482 CC(C)NCC(O)COc1ccc(CC(=O)N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K05 compound treatment 44080.0 -192000.0 -5.12 32840.0 -199000.0 -5.07 -7.2025 -1.0 731 SPBio_001483 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K06 compound treatment 201440.0 -34600.0 -0.92 232520.0 404.0 0.01 -0.6457 -0.6992 990 SPBio_001484 CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K07 compound treatment 211800.0 -24300.0 -0.65 201520.0 -30600.0 -0.78 -1.0077 -0.9958 972 SPBio_001485 CN(C)S(=O)(=O)c1ccc2Sc3ccccc3/C(=C\CCN4CCN(C)CC4)/c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K08 compound treatment 214560.0 -21500.0 -0.57 205760.0 -26400.0 -0.67 -0.8794 -0.997 338 SPBio_001486 Nc1ccncc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K09 compound treatment 233840.0 -2230.0 -0.06 243360.0 11200.0 0.29 0.1601 0.5481 833 SPBio_001487 CC(C)(C)NC[C@@H](O)COc1nsnc1N2CCOCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K10 compound treatment 234920.0 -1150.0 -0.03 224560.0 -7560.0 -0.19 -0.1576 -0.8099 783 SPBio_001488 CO[C@@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]2Cc4cn(C)c5cccc1c45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K11 compound treatment 238760.0 2690.0 0.07 237280.0 5160.0 0.13 0.1435 0.9594 2572 SPBio_001489 COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c32)cc7)N(C)CCc6cc5OC)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K12 compound treatment 102160.0 -134000.0 -3.57 126120.0 -106000.0 -2.7 -4.4304 -0.9904 86 SPBio_001490 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCN(C)Cc3ccccc3)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K13 compound treatment 244280.0 8210.0 0.22 240360.0 8240.0 0.21 0.303 0.9998 1000109 SPBio_001491 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K14 compound treatment 249920.0 13800.0 0.37 252000.0 19900.0 0.51 0.6186 0.9881 1016 SPBio_001492 CN1CCOC(c2ccccc2)c3ccccc3C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K15 compound treatment 242040.0 5970.0 0.16 222080.0 -10000.0 -0.26 -0.0679 -0.2259 883 SPBio_001493 CC(Oc1ccccc1)C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K16 compound treatment 233800.0 -2270.0 -0.06 241880.0 9760.0 0.25 0.1327 0.5193 786 SPBio_001494 CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K17 compound treatment 212560.0 -23500.0 -0.63 209640.0 -22500.0 -0.57 -0.8474 -0.9989 824 SPBio_001495 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@@](O)(C(=O)OC)n4c5ccccc35 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K18 compound treatment 231280.0 -4790.0 -0.13 236880.0 4760.0 0.12 -0.0047 -0.0267 741 SPBio_001496 Cc1ccccc1OCC(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K19 compound treatment 232360.0 -3710.0 -0.1 232040.0 -76.2 0.0 -0.0714 -0.7208 1052 SPBio_001497 CC[C@H]1CN2CCC1C[C@@H]2[C@@H](O)c3ccnc4ccc(OC)cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K20 compound treatment 225640.0 -10400.0 -0.28 232040.0 -76.2 0.0 -0.1981 -0.712 751 SPBio_001498 COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K21 compound treatment 247920.0 11800.0 0.32 245480.0 13400.0 0.34 0.4636 0.9993 1223 SPBio_001499 CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K22 compound treatment 225800.0 -10300.0 -0.27 234520.0 2400.0 0.06 -0.1504 -0.5361 1241 SPBio_001500 NC(=N)NS(=O)(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K23 mock treatment 217560.0 -18500.0 -0.49 253120.0 21000.0 0.53 0.0286 0.0393 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 K24 mock treatment 249760.0 13700.0 0.36 231080.0 -1040.0 -0.03 0.2394 0.6544 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L01 mock treatment 279240.0 43200.0 1.15 252080.0 20000.0 0.51 1.1728 0.9323 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L02 mock treatment 261240.0 25200.0 0.67 265640.0 33500.0 0.85 1.0772 0.993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L03 compound treatment 231080.0 -4990.0 -0.13 223400.0 -8720.0 -0.22 -0.2508 -0.9703 3198432 SPBio_001501 CSC(=N)NCCC[C@@H](N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L04 compound treatment 222800.0 -13300.0 -0.35 223960.0 -8160.0 -0.21 -0.3969 -0.9676 1269 SPBio_001502 CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L05 compound treatment 230400.0 -5670.0 -0.15 243400.0 11300.0 0.29 0.0959 0.2958 3198433 SPBio_001503 NC(Cc1c[nH]cn1)C(=O)Nc2ccc3ccccc3c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L06 compound treatment 238160.0 2090.0 0.06 232680.0 564.0 0.01 0.0495 0.8611 1486 SPBio_001504 CC(C)NCC(O)COc1ccc(NC(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L07 compound treatment 19680.0 -216000.0 -5.77 18240.0 -214000.0 -5.44 -7.925 -0.9996 3176939 SPBio_001505 ClCC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L08 compound treatment 219040.0 -17000.0 -0.45 219640.0 -12500.0 -0.32 -0.5454 -0.9846 1415 SPBio_001506 FC(F)(F)c1cccc(c1)N2CCNCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L09 compound treatment 241400.0 5330.0 0.14 236000.0 3880.0 0.1 0.1703 0.9842 3198434 SPBio_001507 NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L10 compound treatment 208120.0 -28000.0 -0.75 195160.0 -37000.0 -0.94 -1.1914 -0.9934 419 SPBio_001508 CC1=NN(C(=O)C1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L11 compound treatment 248360.0 12300.0 0.33 246160.0 14000.0 0.36 0.4842 0.9991 3079214 SPBio_001509 CC(C)CC(NC(=O)CN)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L12 compound treatment 231320.0 -4750.0 -0.13 224680.0 -7440.0 -0.19 -0.2233 -0.9811 907188 SPBio_001510 COc1cccc(OC)c1OCCNCC2COc3ccccc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L13 compound treatment 229680.0 -6390.0 -0.17 247000.0 14900.0 0.38 0.1471 0.3544 3198435 SPBio_001511 N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L14 compound treatment 103560.0 -133000.0 -3.53 103800.0 -128000.0 -3.26 -4.8053 -0.9992 1478 SPBio_001512 Cc1ccc(cc1)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L15 compound treatment 23800.0 -212000.0 -5.66 24400.0 -208000.0 -5.28 -7.7366 -0.9994 2269 SPBio_001513 Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L16 compound treatment 258880.0 22800.0 0.61 213200.0 -18900.0 -0.48 0.0899 0.1159 445 SPBio_001514 NC(=O)c1cccc(N)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L17 compound treatment 223360.0 -12700.0 -0.34 196920.0 -35200.0 -0.89 -0.8725 -0.9117 3054972 SPBio_001515 CC(C)C1=CC2=CCC3[C@](C)(CCC[C@]3(C)C2CC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L18 compound treatment 240920.0 4850.0 0.13 235560.0 3440.0 0.09 0.1533 0.982 1248 SPBio_001516 C[C@@]12CCC3C(CCc4cc(OC(=O)CCC(=O)O)ccc34)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L19 compound treatment 225280.0 -10800.0 -0.29 277600.0 45500.0 1.16 0.6143 0.5155 3079215 SPBio_001517 CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L20 compound treatment 252640.0 16600.0 0.44 232120.0 3.81 0.0 0.3124 0.7073 2060318 SPBio_001518 C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@]12O[C@]2(C)C[C@@H](O)CC1(C)C)/C=C/C=C(\C)/C=C/C3=C(C)C[C@@H](O)CC3(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L21 compound treatment 232160.0 -3910.0 -0.1 247960.0 15800.0 0.4 0.2111 0.5073 740 SPBio_001519 N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L22 compound treatment 221680.0 -14400.0 -0.38 228120.0 -4000.0 -0.1 -0.3432 -0.8645 1023 SPBio_001520 CN[C@H](CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L23 mock treatment 224960.0 -11100.0 -0.3 240800.0 8680.0 0.22 -0.0534 -0.1445 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 L24 mock treatment 228200.0 -7870.0 -0.21 211480.0 -20600.0 -0.52 -0.5194 -0.9192 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M01 mock treatment 260320.0 24200.0 0.65 197960.0 -34200.0 -0.87 -0.157 -0.145 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M02 mock treatment 252600.0 16500.0 0.44 237280.0 5160.0 0.13 0.4044 0.8796 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M03 compound treatment 243720.0 7650.0 0.2 210720.0 -21400.0 -0.54 -0.2405 -0.414 2069343 SPBio_001521 COc1ccc2[C@H](OC(=O)c2c1OC)[C@H]3N(C)CCc4cc5OCOc5cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M04 compound treatment 229000.0 -7070.0 -0.19 201280.0 -30800.0 -0.78 -0.6878 -0.8528 1529 SPBio_001522 COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M05 compound treatment 209560.0 -26500.0 -0.71 207800.0 -24300.0 -0.62 -0.937 -0.9978 949 SPBio_001523 OC(=O)c1cc(O)c2ccccc2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M06 compound treatment 18160.0 -218000.0 -5.81 16400.0 -216000.0 -5.48 -7.9868 -0.9996 871 SPBio_001524 Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M07 compound treatment 238480.0 2410.0 0.06 196280.0 -35800.0 -0.91 -0.5989 -0.6557 362 SPBio_001525 CCN(CC)CC(=O)Nc1c(C)cccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M08 compound treatment 234920.0 -1150.0 -0.03 212200.0 -19900.0 -0.51 -0.3798 -0.7486 3480067 SPBio_001526 CC(NCCc1ccc(O)cc1)C(O)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M09 compound treatment 238840.0 2770.0 0.07 230520.0 -1600.0 -0.04 0.0235 0.2788 988 SPBio_001527 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M10 compound treatment 258040.0 22000.0 0.59 225760.0 -6360.0 -0.16 0.2999 0.4936 3058009 SPBio_001528 CCN1CCC(CNC(=O)c2cc(ccc2OC)S(=O)(=O)N)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M11 compound treatment 241840.0 5770.0 0.15 214160.0 -18000.0 -0.46 -0.2141 -0.4444 898 SPBio_001529 CCOC(=O)C(Cc1ccc(O)cc1)NC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M12 compound treatment 262960.0 26900.0 0.72 216960.0 -15200.0 -0.39 0.2344 0.288 1068 SPBio_001530 CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(CN(C)C)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M13 compound treatment 232480.0 -3590.0 -0.1 230520.0 -1600.0 -0.04 -0.0964 -0.9269 993 SPBio_001531 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M14 compound treatment 241960.0 5890.0 0.16 226000.0 -6120.0 -0.16 0.001 0.0047 1180 SPBio_001532 Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M15 compound treatment 227000.0 -9070.0 -0.24 207560.0 -24600.0 -0.62 -0.6125 -0.9148 1073 SPBio_001533 CC(N)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M16 compound treatment 24880.0 -211000.0 -5.63 21440.0 -211000.0 -5.36 -7.7695 -0.9997 998 SPBio_001534 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M17 compound treatment 229600.0 -6470.0 -0.17 209680.0 -22400.0 -0.57 -0.5254 -0.8816 1017 SPBio_001535 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M18 compound treatment 225040.0 -11000.0 -0.29 218920.0 -13200.0 -0.34 -0.4453 -0.9978 1094 SPBio_001536 COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M19 compound treatment 239120.0 3050.0 0.08 228120.0 -4000.0 -0.1 -0.0144 -0.1106 1034 SPBio_001537 CC(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M20 compound treatment 243240.0 7170.0 0.19 231160.0 -956.0 -0.02 0.1179 0.6122 887 SPBio_001538 COc1ccc(NS(=O)(=O)c2ccc(N)cc2)nn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M21 compound treatment 223320.0 -12800.0 -0.34 206800.0 -25300.0 -0.64 -0.6956 -0.9555 1523 SPBio_001539 CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M22 compound treatment 200040.0 -36000.0 -0.96 214280.0 -17800.0 -0.45 -1.0 -0.9413 1102 SPBio_001540 CC(C(=O)O)c1ccc(cc1)C(=O)c2cccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M23 mock treatment 216480.0 -19600.0 -0.52 225080.0 -7040.0 -0.18 -0.4959 -0.8981 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 M24 mock treatment 224880.0 -11200.0 -0.3 218160.0 -14000.0 -0.35 -0.4619 -0.9963 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N01 mock treatment 253360.0 17300.0 0.46 223000.0 -9120.0 -0.23 0.162 0.314 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N02 mock treatment 235880.0 -192.0 -0.01 222520.0 -9600.0 -0.24 -0.1762 -0.7218 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N03 compound treatment 229440.0 -6630.0 -0.18 225080.0 -7040.0 -0.18 -0.2515 -1.0 3054980 SPBio_001541 Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](CO)O3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N04 compound treatment 227840.0 -8230.0 -0.22 214000.0 -18100.0 -0.46 -0.4809 -0.9425 3174610 SPBio_001542 COc1cc(cc(OC)c1OC)C(=O)O[C@H]2CC[C@@]3(C)[C@@H]4CC[C@@H]5[C@@]3(C[C@@]6(O)[C@@H]7CN8C[C@@H](C)CC[C@H]8[C@@](C)(O)[C@@]7(O)[C@@H](O)C[C@@]56O)O[C@@]42O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N05 compound treatment 238640.0 2570.0 0.07 219000.0 -13100.0 -0.33 -0.1874 -0.5505 2060304 SPBio_001543 OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N06 compound treatment 212800.0 -23300.0 -0.62 216200.0 -15900.0 -0.4 -0.7249 -0.9786 882 SPBio_001544 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N07 compound treatment 221840.0 -14200.0 -0.38 208360.0 -23800.0 -0.6 -0.6954 -0.9749 2060308 SPBio_001545 C/C(=C/C(=O)O)/C=C/C1(O)C(=CC(=O)CC1(C)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N08 compound treatment 20040.0 -216000.0 -5.76 17280.0 -215000.0 -5.46 -7.9355 -0.9996 3198436 SPBio_001546 CO[C@H]1CC(O[C@H]/2[C@@H](C)\C=C\C=C\3/CO[C@@H]4\C(=N/O)\C(=C[C@@H](C(=O)O[C@H]5C[C@@H](C\C=C2/C)O[C@@]6(CC[C@H](C)[C@H](O6)C7CCCCC7)C5)[C@@]43O)C)O[C@@H](C)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N09 compound treatment 221240.0 -14800.0 -0.4 190440.0 -41700.0 -1.06 -1.0289 -0.9097 1039 SPBio_001547 CC[C@]1(CCCN2CCc3c4[C@@H]21)CC(=O)n4c5ccccc35 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N10 compound treatment 111880.0 -124000.0 -3.31 90520.0 -142000.0 -3.6 -4.8872 -0.9991 1389 SPBio_001548 CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc4cccnc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N11 compound treatment 252760.0 16700.0 0.44 215080.0 -17000.0 -0.43 0.0083 0.0134 1583 SPBio_001549 COc1ccc(/C=C/c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N12 compound treatment 119200.0 -117000.0 -3.12 85680.0 -146000.0 -3.72 -4.8362 -0.9961 3174609 SPBio_001550 CC(C)c1c(C(=O)c2ccccc2)c(c(c3ccc(F)cc3)n1CC[C@@H](O)C[C@@H](O)CC(=O)O)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N13 compound treatment 172880.0 -63200.0 -1.68 177040.0 -55100.0 -1.4 -2.1816 -0.9958 1010348 SPBio_001551 OC1=CC(=O)c2ccccc2C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N14 compound treatment 227040.0 -9030.0 -0.24 216600.0 -15500.0 -0.39 -0.4493 -0.972 3172973 SPBio_001552 COC(=O)[C@@]1(O)OC[C@]2(C3[C@H]4OC[C@@]3([C@@H](C[C@@H]2OC(=O)/C(=C/C)/C)OC(=O)C)C(=O)OC)[C@@H]1[C@@](C)([C@@H]4O)C56O[C@@]6(C)[C@H]7C[C@@H]5OC8OC=C[C@]78O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N15 compound treatment 249440.0 13400.0 0.36 201920.0 -30200.0 -0.77 -0.2909 -0.3436 3054057 SPBio_001553 CC(=CCC/C(=C/CCC(C)(O)C=C)/C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N16 compound treatment 32600.0 -203000.0 -5.43 28000.0 -204000.0 -5.19 -7.506 -0.9998 1520 SPBio_001554 CC[n+]1c(c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N17 compound treatment 215480.0 -20600.0 -0.55 203000.0 -29100.0 -0.74 -0.9117 -0.9892 1002002 SPBio_001555 O[C@@H]1CC(=C[C@@H](O)[C@H]1O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N18 compound treatment 252640.0 16600.0 0.44 190800.0 -41300.0 -1.05 -0.4305 -0.3777 1457 SPBio_001556 CC(=O)OCC(=O)[C@]12OC3(CCCC3)O[C@@H]2CC4C5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@@]41C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N19 compound treatment 109040.0 -127000.0 -3.39 101480.0 -131000.0 -3.32 -4.7437 -1.0 797 SPBio_001557 CC[C@]1(CC[C@@H](O1)[C@]2(C)CCC3(C[C@H](O)[C@@H](C)[C@H](O3)[C@H](C)[C@@H](OC)[C@H](C)C(=O)O)O2)C4O[C@H](C[C@@H]4C)C5O[C@@](O)(CC)[C@H](C)C[C@@H]5C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N20 compound treatment 221880.0 -14200.0 -0.38 204760.0 -27400.0 -0.7 -0.7594 -0.9591 1357 SPBio_001558 CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N21 compound treatment 226880.0 -9190.0 -0.25 219320.0 -12800.0 -0.33 -0.4034 -0.9902 1000111 SPBio_001559 OC(=O)CCCCC1SCC2NC(=O)NC12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N22 compound treatment 232520.0 -3550.0 -0.09 226120.0 -6000.0 -0.15 -0.1748 -0.9738 864 SPBio_001560 Oc1noc2CNCCc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N23 mock treatment 240760.0 4690.0 0.12 225200.0 -6920.0 -0.18 -0.036 -0.1667 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 N24 mock treatment 248840.0 12800.0 0.34 210840.0 -21300.0 -0.54 -0.1418 -0.2219 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O01 mock treatment 237600.0 1530.0 0.04 223600.0 -8520.0 -0.22 -0.1243 -0.5642 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O02 mock treatment 257680.0 21600.0 0.58 228960.0 -3160.0 -0.08 0.3506 0.6028 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O03 compound treatment 231200.0 -4870.0 -0.13 210760.0 -21400.0 -0.54 -0.4758 -0.8522 1407 SPBio_001561 NC(COCc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O04 compound treatment 252080.0 16000.0 0.43 221520.0 -10600.0 -0.27 0.1113 0.2205 1237 SPBio_001562 CC(=O)Nc1ccc(OC(=O)c2ccccc2O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O05 compound treatment 249200.0 13100.0 0.35 243880.0 11800.0 0.3 0.459 0.9969 1026 SPBio_001563 CC(=O)NC(Cc1ccccc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O06 compound treatment 223560.0 -12500.0 -0.33 214040.0 -18100.0 -0.46 -0.5609 -0.9876 821 SPBio_001564 O=C1NS(=O)(=O)c2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O07 compound treatment 235680.0 -392.0 -0.01 194760.0 -37400.0 -0.95 -0.679 -0.7149 987 SPBio_001565 CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O08 compound treatment 237760.0 1690.0 0.04 203840.0 -28300.0 -0.72 -0.4766 -0.6616 1122 SPBio_001566 N(=Nc1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O09 compound treatment 243080.0 7010.0 0.19 206080.0 -26000.0 -0.66 -0.336 -0.4885 874 SPBio_001567 CC(C)CC(NC(=O)CCN)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O10 compound treatment 250200.0 14100.0 0.38 224120.0 -8000.0 -0.2 0.1226 0.2864 738 SPBio_001568 CC(=O)Nc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O11 compound treatment 385160.0 149000.0 3.98 239520.0 7400.0 0.19 2.9439 0.7398 2060457 SPBio_001569 COc1cc(O)c2c(=O)cc(oc2c1)c3ccc(O)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O12 compound treatment 250200.0 14100.0 0.38 229000.0 -3120.0 -0.08 0.2103 0.5464 684 SPBio_001570 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(=O)CC)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O13 compound treatment 221320.0 -14800.0 -0.39 244360.0 12200.0 0.31 -0.058 -0.1156 1006104 SPBio_001571 Cc1cc(=O)oc2cc(O)cc(O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O14 compound treatment 18160.0 -218000.0 -5.81 15120.0 -217000.0 -5.52 -8.0098 -0.9997 3059431 SPBio_001572 CCC(=O)O[C@H]1CCC2C3CCc4cc(O)ccc4C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O15 compound treatment 245240.0 9170.0 0.24 223720.0 -8400.0 -0.21 0.0219 0.0674 2060475 SPBio_001573 COc1cc(OC)c2C(=O)CC(Oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O16 compound treatment 146760.0 -89300.0 -2.38 141320.0 -90800.0 -2.31 -3.3163 -0.9999 813 SPBio_001574 CC(=O)O[C@H]1CCC2C3CCc4cc(OC(=O)C)ccc4C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O17 compound treatment 253840.0 17800.0 0.47 178920.0 -53200.0 -1.35 -0.6215 -0.4336 2060277 SPBio_001575 COc1cccc2c(=O)c(OC)c(oc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O18 compound treatment 254400.0 18300.0 0.49 187200.0 -44900.0 -1.14 -0.462 -0.3719 3177458 SPBio_001576 CC(=O)Oc1ccc2C3CC[C@@]4(C)C(CCC4=O)C3CCc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O19 compound treatment 222200.0 -13900.0 -0.37 211080.0 -21000.0 -0.53 -0.6398 -0.9838 1554635 SPBio_001577 COc1cc(OC)c2c(=O)cc(oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O20 compound treatment 17920.0 -218000.0 -5.82 15720.0 -216000.0 -5.5 -8.0035 -0.9996 773 SPBio_001578 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O21 compound treatment 266200.0 30100.0 0.8 219240.0 -12900.0 -0.33 0.3365 0.3879 724 SPBio_001579 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O22 compound treatment 253720.0 17600.0 0.47 263600.0 31500.0 0.8 0.8988 0.9679 782 SPBio_001580 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=CC5(C)C4C(O)CC3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O23 mock treatment 301720.0 65600.0 1.75 241560.0 9440.0 0.24 1.4075 0.7967 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 O24 mock treatment 285400.0 49300.0 1.32 235800.0 3680.0 0.09 0.9962 0.7556 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P01 mock treatment 218600.0 -17500.0 -0.47 241680.0 9560.0 0.24 -0.1575 -0.2996 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P02 mock treatment 251440.0 15400.0 0.41 246200.0 14100.0 0.36 0.5429 0.9977 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P03 compound treatment 236800.0 728.0 0.02 214600.0 -17500.0 -0.45 -0.3012 -0.6757 1255 SPBio_001581 NC(=O)c1ccc(cc1Cl)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P04 compound treatment 237480.0 1410.0 0.04 233200.0 1080.0 0.03 0.046 0.9885 1419 SPBio_001582 NCCSSCCN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P05 compound treatment 200880.0 -35200.0 -0.94 144600.0 -87500.0 -2.23 -2.237 -0.9263 1263 SPBio_001583 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P06 compound treatment 241760.0 5690.0 0.15 203600.0 -28500.0 -0.73 -0.4055 -0.5474 1524 SPBio_001584 CC(C)Nc1c(C)n(C)n(c2ccccc2)c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P07 compound treatment 260840.0 24800.0 0.66 189480.0 -42600.0 -1.08 -0.2996 -0.236 1424 SPBio_001585 CCCC(=O)Nc1ncnc2n(cnc12)C3O[C@@H]4COP(=O)(O)O[C@H]4[C@H]3OC(=O)CCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P08 compound treatment 203120.0 -33000.0 -0.88 163560.0 -68600.0 -1.74 -1.8539 -0.9497 1452 SPBio_001586 CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P09 compound treatment 343080.0 107000.0 2.85 202240.0 -29900.0 -0.76 1.4803 0.5014 1246 SPBio_001587 CC[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P10 compound treatment 308800.0 72700.0 1.94 194600.0 -37500.0 -0.95 0.6966 0.3224 1493 SPBio_001588 CCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P11 compound treatment 260960.0 24900.0 0.66 294800.0 62700.0 1.59 1.5962 0.9246 1299 SPBio_001589 Nc1ccc(cc1)C(=O)NCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P12 compound treatment 307920.0 71800.0 1.92 392760.0 161000.0 4.08 4.2428 0.9404 1526 SPBio_001590 CC1CCCC(C)N1NC(=O)c2ccc(Cl)c(c2)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P13 compound treatment 14080.0 -222000.0 -5.92 13120.0 -219000.0 -5.57 -8.1227 -0.9995 1387 SPBio_001591 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P14 compound treatment 167920.0 -68200.0 -1.82 70440.0 -162000.0 -4.11 -4.1917 -0.9326 1431 SPBio_001592 Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P15 compound treatment 264160.0 28100.0 0.75 209640.0 -22500.0 -0.57 0.1254 0.1332 872 SPBio_001593 CCN(CC)CCOC(=O)C(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P16 compound treatment 260320.0 24200.0 0.65 176240.0 -55900.0 -1.42 -0.5475 -0.3507 3045655 SPBio_001594 CC(=O)[C@@]1(O)CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5CC5[C@]4(C)C3CC[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P17 compound treatment 240000.0 3930.0 0.1 179400.0 -52700.0 -1.34 -0.8738 -0.6499 701 SPBio_001595 Nc1c(Br)cc(Br)cc1CNC2CCC(O)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P18 compound treatment 262760.0 26700.0 0.71 190800.0 -41300.0 -1.05 -0.2397 -0.1889 3172846 SPBio_001596 NC(CO)(CO)CO.OC(=O)C1CCn2c(ccc12)C(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P19 compound treatment 258680.0 22600.0 0.6 220640.0 -11500.0 -0.29 0.2199 0.3284 3174106 SPBio_001597 CN(C)CCCO[C@H]1[C@H](OC2OC(C)(C)O[C@H]12)C(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P20 compound treatment 253800.0 17700.0 0.47 220680.0 -11400.0 -0.29 0.1286 0.2318 1453 SPBio_001598 CN1CCCN=C1/C=C/c2sccc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P21 compound treatment 258320.0 22200.0 0.59 248480.0 16400.0 0.42 0.7136 0.985 818 SPBio_001599 CCC1(CC)C(=O)NC=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P22 compound treatment 245880.0 9810.0 0.26 258720.0 26600.0 0.68 0.6632 0.9145 1461 SPBio_001600 CN1CCCN=C1COC(=O)C(O)(C2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P23 mock treatment 267520.0 31400.0 0.84 262240.0 30100.0 0.77 1.1345 0.999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2162 P24 mock treatment 267120.0 31000.0 0.83 226640.0 -5480.0 -0.14 0.4869 0.58 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A01 mock treatment 210800.0 -8160.0 -0.22 230320.0 7180.0 0.18 -0.0247 -0.0871 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A02 mock treatment 222320.0 3360.0 0.09 216520.0 -6620.0 -0.17 -0.0557 -0.2918 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A03 compound treatment 222520.0 3560.0 0.1 214080.0 -9060.0 -0.23 -0.0958 -0.3842 3045683 SPBio_001601 C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A04 compound treatment 22400.0 -197000.0 -5.24 16960.0 -206000.0 -5.24 -7.4128 -1.0 3177591 SPBio_001602 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](OC(=O)C)c4cc5OCOc5cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A05 compound treatment 9840.0 -209000.0 -5.58 8680.0 -214000.0 -5.45 -7.7984 -0.9999 1465 SPBio_001603 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A06 compound treatment 233360.0 14400.0 0.38 211200.0 -11900.0 -0.3 0.0568 0.1161 2475 SPBio_001604 CC(=CC1C(C(=O)O)C1(C)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A07 compound treatment 223880.0 4920.0 0.13 175400.0 -47700.0 -1.21 -0.7656 -0.627 1489 SPBio_001605 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A08 compound treatment 176600.0 -42400.0 -1.13 159320.0 -63800.0 -1.62 -1.946 -0.9843 1013144 SPBio_001606 O=C1OC(=O)C2C3CCC(O3)C21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A09 compound treatment 214560.0 -4400.0 -0.12 193920.0 -29200.0 -0.74 -0.6083 -0.8087 1459 SPBio_001607 OC1CCN(CCCN2c3ccccc3Sc4ccc(C#N)cc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A10 compound treatment 223000.0 4040.0 0.11 214520.0 -8620.0 -0.22 -0.0788 -0.3225 3059791 SPBio_001608 Nc1nc(cs1)/C(=C/CC(=O)O)/C(=O)N[C@H]2[C@H]3SCC=C(N3C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A11 compound treatment 226040.0 7080.0 0.19 226520.0 3380.0 0.09 0.1943 0.9364 1495 SPBio_001609 OC(=O)CCCCC1CCSS1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A12 compound treatment 242840.0 23900.0 0.64 233560.0 10400.0 0.26 0.6376 0.9245 3059465 SPBio_001610 Nc1nc(cs1)/C(=N/O)/C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A13 compound treatment 210240.0 -8720.0 -0.23 147800.0 -75300.0 -1.92 -1.5189 -0.7871 1317 SPBio_001611 Fc1ccc(cc1)C(c2ccccc2)(c3ccccc3F)n4ccnc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A14 compound treatment 195920.0 -23000.0 -0.61 135720.0 -87400.0 -2.22 -2.0061 -0.8699 3480112 SPBio_001612 CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A15 compound treatment 238440.0 19500.0 0.52 208880.0 -14300.0 -0.36 0.1109 0.175 1605 SPBio_001613 OC(Cn1cncn1)(Cn2cncn2)c3ccc(F)cc3F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A16 compound treatment 226720.0 7760.0 0.21 207920.0 -15200.0 -0.39 -0.1273 -0.2901 3079224 SPBio_001614 COC1=C(O)C(=O)c2c(O)c3c(O)c(oc3cc2C1=O)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A17 compound treatment 240200.0 21200.0 0.57 213480.0 -9660.0 -0.25 0.2268 0.3673 839435 SPBio_001615 NCCCCNC(=N)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A18 compound treatment 228760.0 9800.0 0.26 220040.0 -3100.0 -0.08 0.129 0.4726 3079225 SPBio_001616 OC(=O)CCC1NCC2CC1CN3CCCCC23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A19 compound treatment 233680.0 14700.0 0.39 205400.0 -17700.0 -0.45 -0.0414 -0.0693 3250 SPBio_001617 CCCCCCCCCCCCCCCCCCOCC(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A20 compound treatment 237480.0 18500.0 0.49 220320.0 -2820.0 -0.07 0.2985 0.5981 1592184 SPBio_001618 O=C1CCCC2C3CC(CN21)[C@@H]4CCCCN4C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A21 compound treatment 238120.0 19200.0 0.51 223800.0 658.0 0.02 0.3731 0.7299 1537011 SPBio_001619 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A22 compound treatment 246560.0 27600.0 0.74 214200.0 -8940.0 -0.23 0.3596 0.4669 3079226 SPBio_001620 C1CN2Cc3ccccc3N=C2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A23 mock treatment 246920.0 28000.0 0.75 226240.0 3100.0 0.08 0.5829 0.7775 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 A24 mock treatment 220560.0 1600.0 0.04 225560.0 2420.0 0.06 0.0737 0.9842 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B01 mock treatment 242080.0 23100.0 0.62 236760.0 13600.0 0.35 0.6808 0.9628 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B02 mock treatment 224440.0 5480.0 0.15 223360.0 218.0 0.01 0.1073 0.7333 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B03 compound treatment 147720.0 -71200.0 -1.9 137880.0 -85300.0 -2.17 -2.876 -0.9978 2060222 SPBio_001621 C/C/1=C\CCC(=O)C2CC(C)(C)C2CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B04 compound treatment 229160.0 10200.0 0.27 213200.0 -9940.0 -0.25 0.0136 0.0366 2515 SPBio_001622 CCCCCCC(C)OC(=O)COc1cc(Cl)c(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B05 compound treatment 101880.0 -117000.0 -3.12 85800.0 -137000.0 -3.49 -4.6766 -0.9984 1099943 SPBio_001623 COc1c2C=CC(C)(C)Oc2c(CC=C(C)C)c3oc(=O)c(c(O)c13)c4ccc(O)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B06 compound treatment 41360.0 -178000.0 -4.74 17640.0 -206000.0 -5.23 -7.0431 -0.9988 2517 SPBio_001624 CC(C)N(C(=O)CCl)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B07 compound treatment 212320.0 -6640.0 -0.18 200680.0 -22500.0 -0.57 -0.529 -0.8847 2060382 SPBio_001625 C/C/1=C\CC(C)(C)\C=C\CC2(C)OC2CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B08 compound treatment 242640.0 23700.0 0.63 212640.0 -10500.0 -0.27 0.2577 0.3758 2518 SPBio_001626 CCCCSP(=O)(SCCCC)SCCCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B09 compound treatment 235600.0 16600.0 0.44 213240.0 -9900.0 -0.25 0.1357 0.266 1981222 SPBio_001627 CCN1CCN(C(=O)NC(C(=O)NC2C3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4C)c5ccc(O)cc5)C(=O)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B10 compound treatment 257920.0 39000.0 1.04 212000.0 -11100.0 -0.28 0.5342 0.4961 2519 SPBio_001628 CC(C)N(C(C)C)C(=O)SCC(=C(Cl)Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B11 compound treatment 227160.0 8200.0 0.22 225200.0 2060.0 0.05 0.1916 0.8522 3174236 SPBio_001629 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cc(cc34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B12 compound treatment 213720.0 -5240.0 -0.14 195440.0 -27700.0 -0.7 -0.5968 -0.8311 2479 SPBio_001630 CCOP(=S)(OCC)Oc1ccc2c(C)c(Cl)c(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B13 compound treatment 231840.0 12900.0 0.34 199240.0 -23900.0 -0.61 -0.1869 -0.2677 2060221 SPBio_001631 COc1ccc(cc1)[C@H]2Oc3cc(OC)cc(OC)c3C[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B14 compound treatment 221760.0 2800.0 0.07 226480.0 3340.0 0.08 0.1129 0.998 2480 SPBio_001632 COP(=S)(OC)SCn1nnc2ccccc2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B15 compound treatment 207440.0 -11500.0 -0.31 184480.0 -38700.0 -0.98 -0.9123 -0.8858 2060258 SPBio_001633 CC(=O)O[C@H]1Cc2c(OC(=O)C)cc(OC(=O)C)cc2O[C@@H]1c3ccc(OC(=O)C)c(OC(=O)C)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B16 compound treatment 217000.0 -1960.0 -0.05 209480.0 -13700.0 -0.35 -0.2825 -0.8043 2513 SPBio_001634 OC(=O)CNCP(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B17 compound treatment 234720.0 15800.0 0.42 199480.0 -23700.0 -0.6 -0.1282 -0.1747 2060256 SPBio_001635 CC(=CC1C(CO)C1(C)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B18 compound treatment 207400.0 -11600.0 -0.31 201040.0 -22100.0 -0.56 -0.6153 -0.96 2514 SPBio_001636 CCCCCCC(C)OC(=O)COc1ccc(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B19 compound treatment 242640.0 23700.0 0.63 213600.0 -9540.0 -0.24 0.2749 0.4064 1952709 SPBio_001637 COc1ccc2c(C)cc(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B20 compound treatment 258000.0 39000.0 1.04 221520.0 -1620.0 -0.04 0.7069 0.6786 2478 SPBio_001638 COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B21 compound treatment 228760.0 9800.0 0.26 166040.0 -57100.0 -1.45 -0.8418 -0.5706 1000110 SPBio_001639 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B22 compound treatment 236480.0 17500.0 0.47 214720.0 -8420.0 -0.21 0.1789 0.3482 2512 SPBio_001640 COC(=O)COc1cc(Cl)c(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B23 mock treatment 248320.0 29400.0 0.78 240200.0 17100.0 0.43 0.8603 0.9612 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 B24 mock treatment 227840.0 8880.0 0.24 219800.0 -3340.0 -0.08 0.1074 0.4267 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C01 mock treatment 224800.0 5840.0 0.16 228240.0 5100.0 0.13 0.2018 0.9958 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C02 mock treatment 226600.0 7640.0 0.2 207920.0 -15200.0 -0.39 -0.1296 -0.2963 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C03 compound treatment 56840.0 -162000.0 -4.32 51320.0 -172000.0 -4.37 -6.1457 -1.0 3172723 SPBio_001641 CC(=O)OC[C@@]1(O)C[C@@]2(C[C@H]1CCC23)CCC4c5ccoc5CC[C@@]43C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C04 compound treatment 202920.0 -16000.0 -0.43 203200.0 -19900.0 -0.51 -0.6609 -0.9964 3198437 SPBio_001642 C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OC[C@H]1OC([C@H](O)[C@@H]1O)n2ccc(N)nc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C05 compound treatment 154720.0 -64200.0 -1.71 143120.0 -80000.0 -2.03 -2.6498 -0.9963 1978 SPBio_001643 OC(=O)/C=C/c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C06 compound treatment 219320.0 363.0 0.01 215240.0 -7900.0 -0.2 -0.1352 -0.6723 3079227 SPBio_001644 [O-][N+](=O)/N=C/1\NCCN1Cc2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C07 compound treatment 224080.0 5120.0 0.14 212560.0 -10600.0 -0.27 -0.0937 -0.3104 2060330 SPBio_001645 OC[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C08 compound treatment 214240.0 -4720.0 -0.13 220360.0 -2780.0 -0.07 -0.139 -0.963 3079228 SPBio_001646 CCNC(=O)CC[C@H](N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C09 compound treatment 233520.0 14600.0 0.39 201640.0 -21500.0 -0.55 -0.112 -0.1671 2060332 SPBio_001647 OC/C=C/c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C10 compound treatment 131480.0 -87500.0 -2.33 93360.0 -130000.0 -3.3 -3.9826 -0.9856 3076175 SPBio_001648 COc1cc(ccc1O)[C@H]2Oc3cc(ccc3O[C@@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C11 compound treatment 226080.0 7120.0 0.19 217400.0 -5740.0 -0.15 0.031 0.1296 907149 SPBio_001649 CN(C)c1nc(N)c(nc1Cl)C(=O)NC(=N)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C12 compound treatment 223920.0 4960.0 0.13 210200.0 -12900.0 -0.33 -0.1391 -0.3922 3198531 SPBio_001650 COc1ccc(cc1)c2oc3c(CC=C(C)C)c(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc(O)c3c(=O)c2O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C13 compound treatment 215480.0 -3480.0 -0.09 220720.0 -2420.0 -0.06 -0.1091 -0.9803 1316 SPBio_001651 CC(C)(C)NCC(O)c1ccccc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C14 compound treatment 222360.0 3400.0 0.09 206840.0 -16300.0 -0.41 -0.2289 -0.5395 1672 SPBio_001652 OC(=O)CCc1nc(c(o1)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C15 compound treatment 114440.0 -105000.0 -2.79 108440.0 -115000.0 -2.92 -4.0328 -0.9997 2060337 SPBio_001653 COc1ccc(cc1O)c2oc3cc(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(O)c3c(=O)c2OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C16 compound treatment 202280.0 -16700.0 -0.44 200000.0 -23100.0 -0.59 -0.7305 -0.9905 1045397 SPBio_001654 COc1ccc(cc1OC)c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C17 compound treatment 97840.0 -121000.0 -3.23 50240.0 -173000.0 -4.4 -5.3921 -0.9885 2060338 SPBio_001655 CC(C)c1ccc2c(CC[C@H]3C4=C(CC[C@@]32C)C(=O)OC4)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C18 compound treatment 207120.0 -11800.0 -0.32 198080.0 -25100.0 -0.64 -0.6738 -0.9475 1034727 SPBio_001656 COc1ccc(cc1)c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C19 compound treatment 218720.0 -237.0 -0.01 209160.0 -14000.0 -0.36 -0.2559 -0.7196 2060340 SPBio_001657 CC(=O)/C(=C\c1ccccc1)/CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C20 compound treatment 215720.0 -3240.0 -0.09 184280.0 -38900.0 -0.99 -0.7597 -0.7659 351 SPBio_001658 CC(C)NCC(O)COc1cccc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C21 compound treatment 14360.0 -205000.0 -5.46 13160.0 -210000.0 -5.34 -7.6327 -0.9999 1020994 SPBio_001659 COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C22 compound treatment 199160.0 -19800.0 -0.53 193840.0 -29300.0 -0.75 -0.9001 -0.9857 2660 SPBio_001660 CCN(C(=O)/C=C/C)c1ccccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C23 mock treatment 212640.0 -6320.0 -0.17 208920.0 -14200.0 -0.36 -0.3748 -0.9395 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 C24 mock treatment 226040.0 7080.0 0.19 218920.0 -4220.0 -0.11 0.0576 0.2653 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D01 mock treatment 227720.0 8760.0 0.23 226240.0 3100.0 0.08 0.2209 0.8959 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D02 mock treatment 221720.0 2760.0 0.07 210000.0 -13100.0 -0.33 -0.1842 -0.5383 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D03 compound treatment 206280.0 -12700.0 -0.34 201520.0 -21600.0 -0.55 -0.6278 -0.9727 2060195 SPBio_001661 CC1(C)CC23C1CCC3(C)C(O)CCC2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D04 compound treatment 211640.0 -7320.0 -0.2 216560.0 -6580.0 -0.17 -0.2563 -0.9971 2510 SPBio_001662 COC(=O)COc1ccc(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D05 compound treatment 218880.0 -76.8 0.0 225840.0 2700.0 0.07 0.0471 0.6857 2060197 SPBio_001663 COC1(C)CCC2OC2(C)CCC3C1CC3(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D06 compound treatment 237720.0 18800.0 0.5 216040.0 -7100.0 -0.18 0.226 0.425 2511 SPBio_001664 COC(=O)CCCOc1ccc(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D07 compound treatment 223240.0 4280.0 0.11 219680.0 -3460.0 -0.09 0.0185 0.1283 2069257 SPBio_001665 CC1(C)CC2C1CCC(=C)C(O)CCC2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D08 compound treatment 196520.0 -22400.0 -0.6 194320.0 -28800.0 -0.73 -0.9412 -0.9949 2509 SPBio_001666 CCc1cccc(CC)c1N(COC)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D09 compound treatment 217040.0 -1920.0 -0.05 219600.0 -3540.0 -0.09 -0.0998 -0.964 2060199 SPBio_001667 CC1(C)CC2C1CCC3(C)OC2(C)CCC3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D10 compound treatment 224360.0 5400.0 0.14 205160.0 -18000.0 -0.46 -0.2214 -0.4619 2507 SPBio_001668 OC(=O)CCCOc1ccc(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D11 compound treatment 218760.0 -197.0 -0.01 216560.0 -6580.0 -0.17 -0.1221 -0.7289 2060200 SPBio_001669 CC12CCC3C(CC3(C)C)C(C)(O)CCC2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D12 compound treatment 238920.0 20000.0 0.53 207920.0 -15200.0 -0.39 0.1027 0.156 2506 SPBio_001670 OC(=O)COc1ccc(Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D13 compound treatment 245560.0 26600.0 0.71 227440.0 4300.0 0.11 0.5788 0.8065 2060202 SPBio_001671 CC1(C)CC2C1CCC3(C)OC2(C)CCC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D14 compound treatment 214440.0 -4520.0 -0.12 231680.0 8540.0 0.22 0.0683 0.2753 2481 SPBio_001672 CCOP(=S)(OCC)SCCSCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D15 compound treatment 212520.0 -6440.0 -0.17 99040.0 -124000.0 -3.16 -2.3526 -0.7445 2060204 SPBio_001673 CC(=O)OC1CC(C)(C)C2CCC3(C)CC12CCC3OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D16 compound treatment 223760.0 4800.0 0.13 228720.0 5580.0 0.14 0.1908 0.9987 2482 SPBio_001674 CCOC(=O)/C=C(\C)/OP(=O)(OC)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D17 compound treatment 219120.0 163.0 0.0 201800.0 -21300.0 -0.54 -0.3806 -0.7014 2060219 SPBio_001675 CC(=O)OC/1CCC(=C)[C@H]2CC(C)(C)[C@@H]2C\C=C1/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D18 compound treatment 203760.0 -15200.0 -0.41 213200.0 -9940.0 -0.25 -0.4653 -0.9742 2483 SPBio_001676 COP(=O)(OC)OC(Br)C(Cl)(Cl)Br 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D19 compound treatment 222440.0 3480.0 0.09 205600.0 -17500.0 -0.45 -0.2497 -0.5481 2060264 SPBio_001677 C[C@@H]1CC[C@]2(CCC3(C)[C@]4(OC2=O)C=CC5[C@@]6(C)CC[C@H](O)C(C)(C)C6CC[C@]53C)C4[C@H]1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D20 compound treatment 211040.0 -7920.0 -0.21 203680.0 -19500.0 -0.49 -0.4992 -0.9278 2485 SPBio_001678 CCS(=O)CCSP(=O)(OC)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D21 compound treatment 15280.0 -204000.0 -5.43 14280.0 -209000.0 -5.31 -7.5952 -0.9999 2060266 SPBio_001679 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC(=O)C4[C@@]5(C)CC[C@H](OC(=O)C)C(C)(C)C5CC[C@]43C)C2[C@H]1C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D22 compound treatment 196920.0 -22000.0 -0.59 207520.0 -15600.0 -0.4 -0.6963 -0.9818 2490 SPBio_001680 CCOP(=S)(OCC)SCSCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D23 mock treatment 223680.0 4720.0 0.13 206760.0 -16400.0 -0.42 -0.2055 -0.4722 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 D24 mock treatment 218400.0 -557.0 -0.01 209200.0 -13900.0 -0.35 -0.2612 -0.7361 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E01 mock treatment 238960.0 20000.0 0.53 215680.0 -7460.0 -0.19 0.243 0.4292 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E02 mock treatment 214800.0 -4160.0 -0.11 199960.0 -23200.0 -0.59 -0.4952 -0.8256 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E03 compound treatment 219200.0 243.0 0.01 210480.0 -12700.0 -0.32 -0.2231 -0.6927 3172852 SPBio_001681 CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)C5CC[C@]43C)C2C1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E04 compound treatment 212520.0 -6440.0 -0.17 218160.0 -4980.0 -0.13 -0.2109 -0.9888 3079229 SPBio_001682 CC1(C)C2CC(O)C(C)(O)CC21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E05 compound treatment 16120.0 -203000.0 -5.41 15640.0 -208000.0 -5.28 -7.5549 -0.9999 3172853 SPBio_001683 C[C@@H]1OC(O[C@@H]2[C@@H](O)[C@@H](O)COC2O[C@H]3CC[C@@]4(C)C(CC[C@]5(C)C4CC=C6C7CC(C)(C)CC[C@@]7(CC[C@]65C)C(=O)O)[C@]3(C)CO)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E06 compound treatment 216400.0 -2560.0 -0.07 220280.0 -2860.0 -0.07 -0.0997 -0.9995 1053060 SPBio_001684 COc1ccc(cc1OC)c2oc3ccccc3c(=O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E07 compound treatment 222040.0 3080.0 0.08 239240.0 16100.0 0.41 0.3475 0.8325 2060345 SPBio_001685 C[C@@H]1OC(O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC(=O)[C@@]45CCC(C)(C)CC5C6=CCC7[C@@]8(C)CC[C@H](OC9OC[C@H](O)[C@H](O)[C@H]9OC%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@@](C)(CO)C8CC[C@@]7(C)[C@]6(C)CC4)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E08 compound treatment 208640.0 -10300.0 -0.28 203800.0 -19300.0 -0.49 -0.5423 -0.9623 1864491 SPBio_001686 COc1ccc(cc1)c2coc3cc(OC)cc(OC)c3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E09 compound treatment 20680.0 -198000.0 -5.29 16400.0 -207000.0 -5.26 -7.4552 -1.0 829 SPBio_001687 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E10 compound treatment 174800.0 -44200.0 -1.18 185520.0 -37600.0 -0.96 -1.5089 -0.9947 3198532 SPBio_001688 COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E11 compound treatment 251600.0 32600.0 0.87 211440.0 -11700.0 -0.3 0.405 0.4403 1054504 SPBio_001689 COc1c(OCC(O)C(C)(C)O)ccc2c(OC)c3ccoc3nc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E12 compound treatment 225600.0 6640.0 0.18 229880.0 6740.0 0.17 0.2464 0.9999 435 SPBio_001690 CC(C)Cn1c(=O)n(C)c(=O)c2nc[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E13 compound treatment 225480.0 6520.0 0.17 226920.0 3780.0 0.1 0.1909 0.9608 1024517 SPBio_001691 COc1cc2CCNC(C)c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E14 compound treatment 217120.0 -1840.0 -0.05 236960.0 13800.0 0.35 0.2138 0.6027 832325 SPBio_001692 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E15 compound treatment 224160.0 5200.0 0.14 227280.0 4140.0 0.11 0.1725 0.9907 3079221 SPBio_001693 O=c1cccc2C3CC(Cn21)[C@@H]4CCCCN4C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E16 compound treatment 172680.0 -46300.0 -1.23 182360.0 -40800.0 -1.04 -1.6057 -0.9963 1099044 SPBio_001694 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2cncn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E17 compound treatment 218840.0 -117.0 0.0 234120.0 11000.0 0.28 0.1952 0.6992 2060358 SPBio_001695 C[C@@H]1CCC2[C@](C)(CO)[C@@H](O)CC[C@]2(C)[C@]31CC[C@@](CO)(CCO)O3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E18 compound treatment 179720.0 -39200.0 -1.05 159000.0 -64100.0 -1.63 -1.893 -0.977 3198533 SPBio_001696 CCc1c(C)c2=Cc3c(C=C)c(C)c4C=c5c(C)c(CCC(=O)O)c6=C7C(C(=O)O)C(=O)c8c(C)c9C=c1n2[Cu](n9c78)(n43)n56 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E19 compound treatment 17760.0 -201000.0 -5.36 15880.0 -207000.0 -5.27 -7.5196 -1.0 2060328 SPBio_001697 CC(C)CC(=O)c1c(O)c(C)c(O)c2c1oc3c(C(=O)CC(C)C)c(O)c(C)c(O)c32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E20 compound treatment 161800.0 -57200.0 -1.52 148280.0 -74900.0 -1.9 -2.4236 -0.9939 1017318 SPBio_001698 NC(=O)c1ccc(N)nc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E21 compound treatment 189160.0 -29800.0 -0.79 189920.0 -33200.0 -0.84 -1.1591 -0.9995 2060307 SPBio_001699 COc1ccc2[C@@H](O)[C@H](Cc3ccc(OC)c(OC)c3)COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E22 compound treatment 196600.0 -22400.0 -0.6 189040.0 -34100.0 -0.87 -1.0346 -0.9833 2109 SPBio_001700 OCc1c[nH]c2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E23 mock treatment 212120.0 -6840.0 -0.18 211960.0 -11200.0 -0.28 -0.3299 -0.9769 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 E24 mock treatment 217000.0 -1960.0 -0.05 199560.0 -23600.0 -0.6 -0.4609 -0.7657 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F01 mock treatment 247840.0 28900.0 0.77 249120.0 26000.0 0.66 1.0116 0.9971 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F02 mock treatment 247080.0 28100.0 0.75 208720.0 -14400.0 -0.37 0.2709 0.3246 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F03 compound treatment 219760.0 803.0 0.02 319960.0 96800.0 2.46 1.7559 0.7132 2060268 SPBio_001701 C[C@@H]1CC[C@]2(CCC3(C)[C@]4(OC2=O)C=CC5[C@@]6(C)CCC(=O)C(C)(C)C6CC[C@]53C)C4[C@H]1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F04 compound treatment 221760.0 2800.0 0.07 228600.0 5460.0 0.14 0.151 0.9579 2486 SPBio_001702 CNC(=O)CSP(=S)(OC)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F05 compound treatment 15840.0 -203000.0 -5.42 14840.0 -208000.0 -5.3 -7.5745 -0.9999 2060270 SPBio_001703 CC(C)c1ccc2c(CCC3C(C)(CCCC32C)C(=O)N)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F06 compound treatment 233040.0 14100.0 0.38 178600.0 -44500.0 -1.13 -0.5353 -0.4487 2488 SPBio_001704 CCOP(=S)(OCC)SCn1c(=O)oc2cc(Cl)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F07 compound treatment 240120.0 21200.0 0.56 208640.0 -14500.0 -0.37 0.1383 0.2051 2060272 SPBio_001705 CC1CCC2C(CC2(C)C)C(=C)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F08 compound treatment 326640.0 108000.0 2.87 217160.0 -5980.0 -0.15 1.9226 0.6687 2489 SPBio_001706 COP(=O)(N)SC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F09 compound treatment 96200.0 -123000.0 -3.27 44320.0 -179000.0 -4.55 -5.5295 -0.987 2060274 SPBio_001707 CC(C)C1CC=C(C)C2CC(=O)C(=CC12)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F10 compound treatment 241280.0 22300.0 0.6 247360.0 24200.0 0.62 0.8563 0.9999 3046265 SPBio_001708 Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F11 compound treatment 238920.0 20000.0 0.53 239440.0 16300.0 0.41 0.6694 0.9923 3053888 SPBio_001709 CC(=CCC[C@](C)(OC(=O)C)C1CCC(=CC1)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F12 compound treatment 268520.0 49600.0 1.32 218120.0 -5020.0 -0.13 0.8441 0.6358 2534 SPBio_001710 ClC(=C(c1ccc(Cl)cc1)c2ccc(Cl)cc2)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F13 compound treatment 94760.0 -124000.0 -3.31 56080.0 -167000.0 -4.25 -5.3452 -0.9924 3053889 SPBio_001711 C[C@@H]1CC[C@H]2C(C)(C)C3CC12CC[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F14 compound treatment 73000.0 -146000.0 -3.89 84200.0 -139000.0 -3.53 -5.2498 -0.9988 1304 SPBio_001712 ClC1=C(Cl)C2(Cl)C3C4CC(C5OC54)C3C1(Cl)C2(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F15 compound treatment 241400.0 22400.0 0.6 219920.0 -3220.0 -0.08 0.3652 0.6046 2069281 SPBio_001713 C[C@@]12CCC3C(CCc4cc(OC(=O)c5ccccc5)ccc34)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F16 compound treatment 20600.0 -198000.0 -5.29 18520.0 -205000.0 -5.2 -7.4186 -1.0 2535 SPBio_001714 CC1(C)C(C(Cl)Cl)C2(Cl)C(Cl)C(Cl)C1(Cl)C2(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F17 compound treatment 219440.0 483.0 0.01 220320.0 -2820.0 -0.07 -0.0416 -0.571 3053891 SPBio_001715 OC(=O)C/C(=C\C(=O)O)/C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F18 compound treatment 208880.0 -10100.0 -0.27 195520.0 -27600.0 -0.7 -0.6866 -0.9131 2536 SPBio_001716 ClC1CC2C(C1Cl)C3(Cl)C(Cl)C(Cl)C2(Cl)C3(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F19 compound treatment 214520.0 -4440.0 -0.12 211280.0 -11900.0 -0.3 -0.2969 -0.9165 1045072 SPBio_001717 NC(CSCSCC(N)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F20 compound treatment 219160.0 203.0 0.01 211040.0 -12100.0 -0.31 -0.2138 -0.6946 2520 SPBio_001718 Clc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F21 compound treatment 212480.0 -6480.0 -0.17 213040.0 -10100.0 -0.26 -0.3037 -0.9813 3054971 SPBio_001719 O[C@@H]1C[C@](O)(C[C@@H](O)[C@@H]1O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F22 compound treatment 16240.0 -203000.0 -5.4 16480.0 -207000.0 -5.25 -7.5375 -0.9999 2521 SPBio_001720 Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F23 mock treatment 216280.0 -2680.0 -0.07 202840.0 -20300.0 -0.52 -0.4155 -0.7973 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 F24 mock treatment 220640.0 1680.0 0.04 214560.0 -8580.0 -0.22 -0.1226 -0.5502 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G01 mock treatment 214960.0 -4000.0 -0.11 224040.0 898.0 0.02 -0.0592 -0.5434 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G02 mock treatment 213320.0 -5640.0 -0.15 222080.0 -1060.0 -0.03 -0.1254 -0.8211 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G03 compound treatment 195880.0 -23100.0 -0.62 178000.0 -45100.0 -1.15 -1.2467 -0.9573 3079222 SPBio_001721 CC(=O)OC[C@H]1O[C@@H](Oc2cc(OC(=O)C)c3c(=O)cc(oc3c2)c4ccc(OC(=O)C)cc4)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G04 compound treatment 19960.0 -199000.0 -5.31 31160.0 -192000.0 -4.88 -7.2034 -0.9991 122 SPBio_001722 C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G05 compound treatment 24520.0 -194000.0 -5.18 22280.0 -201000.0 -5.11 -7.2771 -1.0 2060255 SPBio_001723 CC(=O)Oc1ccc(/C=C/c2cc(OC(=O)C)cc(OC(=O)C)c2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G06 compound treatment 215160.0 -3800.0 -0.1 233240.0 10100.0 0.26 0.11 0.3984 1788 SPBio_001724 NC(=O)CS(=O)C(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G07 compound treatment 195960.0 -23000.0 -0.61 243560.0 20400.0 0.52 -0.0665 -0.0827 3054095 SPBio_001725 CCC(/C=C/[C@@H](C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G08 compound treatment 212480.0 -6480.0 -0.17 231920.0 8780.0 0.22 0.0357 0.1265 3304 SPBio_001726 Fc1ccc(cc1)C(=O)C2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G09 compound treatment 220000.0 1040.0 0.03 256720.0 33600.0 0.85 0.6234 0.7298 3174115 SPBio_001727 CC[C@H](CCC(C)[C@H]1CCC2C3CCC4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G10 compound treatment 19760.0 -199000.0 -5.31 18720.0 -204000.0 -5.2 -7.4309 -0.9999 3055363 SPBio_001728 COc1cc(/C=C/C(=C/C(=O)\C=C\c2ccc(O)c(OC)c2)/O)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G11 compound treatment 28480.0 -190000.0 -5.08 38160.0 -185000.0 -4.7 -6.917 -0.9993 2060290 SPBio_001729 C[C@@H]1OC(O[C@H]2CC[C@@]3(C)C(CC[C@]4(C)C3CC=C5C6CC(C)(C)CC[C@@]6(C(O)C[C@]54C)C(=O)O[C@@H]7OC[C@H](O)[C@@H](O)[C@H]7OC8O[C@@H](C)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@H]8O)C2(C)C)[C@H](O)[C@H](O)[C@H]1O[C@@H]%10OC[C@@H](O)[C@H](O)[C@H]%10O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G12 compound treatment 235040.0 16100.0 0.43 257080.0 33900.0 0.86 0.9134 0.9479 1912 SPBio_001730 [O-][N+](=O)c1cccc2cn[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G13 compound treatment 226160.0 7200.0 0.19 233400.0 10300.0 0.26 0.3202 0.9887 3055472 SPBio_001731 CC(C)CCCC(C)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G14 compound treatment 218600.0 -357.0 -0.01 244320.0 21200.0 0.54 0.374 0.6945 1003535 SPBio_001732 ONC(=O)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G15 compound treatment 207280.0 -11700.0 -0.31 203120.0 -20000.0 -0.51 -0.5801 -0.9722 3055308 SPBio_001733 COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]3[C@@H](C)[C@@H](O)C[C@@H]31 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G16 compound treatment 219520.0 563.0 0.02 211040.0 -12100.0 -0.31 -0.207 -0.6718 2060198 SPBio_001734 COc1ccc2C=C3c4cc(OC)c(OC)cc4OCC3(O)Oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G17 compound treatment 198160.0 -20800.0 -0.55 211400.0 -11700.0 -0.3 -0.6032 -0.9578 2060301 SPBio_001735 COc1ccc(cc1O)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G18 compound treatment 19880.0 -199000.0 -5.31 18360.0 -205000.0 -5.21 -7.4351 -1.0 3198534 SPBio_001736 OCC(O)CC(O)CCCCCCCCCCCC=C.OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G19 compound treatment 230200.0 11200.0 0.3 227600.0 4460.0 0.11 0.2921 0.9115 1119359 SPBio_001737 COc1cc2ccc(=O)oc2c(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G20 compound treatment 230600.0 11600.0 0.31 212120.0 -11000.0 -0.28 0.0213 0.051 3198535 SPBio_001738 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C[C@H](O)[C@]2(C)C3CC[C@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G21 compound treatment 153080.0 -65900.0 -1.76 141720.0 -81400.0 -2.07 -2.7059 -0.9967 3055306 SPBio_001739 C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)[C@@H]2[C@H]1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G22 compound treatment 206800.0 -12200.0 -0.32 214640.0 -8500.0 -0.22 -0.3821 -0.9806 734 SPBio_001740 CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G23 mock treatment 216960.0 -2000.0 -0.05 215040.0 -8100.0 -0.21 -0.1833 -0.8615 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 G24 mock treatment 202800.0 -16200.0 -0.43 214320.0 -8820.0 -0.22 -0.4632 -0.9538 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H01 mock treatment 226560.0 7600.0 0.2 243600.0 20500.0 0.52 0.5112 0.9156 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H02 mock treatment 224560.0 5600.0 0.15 213200.0 -9940.0 -0.25 -0.0731 -0.249 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H03 compound treatment 220560.0 1600.0 0.04 237760.0 14600.0 0.37 0.293 0.7833 1007364 SPBio_001741 CCOC(=O)C1C(C=C(C)C)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H04 compound treatment 219920.0 963.0 0.03 208440.0 -14700.0 -0.37 -0.2462 -0.657 2522 SPBio_001742 CNC(=O)Oc1cccc2CC(C)(C)Oc21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H05 compound treatment 254600.0 35600.0 0.95 222760.0 -383.0 -0.01 0.6651 0.6998 852250 SPBio_001743 C1CCC(NC1)c2cccnc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H06 compound treatment 245920.0 27000.0 0.72 235760.0 12600.0 0.32 0.7352 0.9339 3172728 SPBio_001744 CNC(=O)O/N=C(/C)\SC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H07 compound treatment 231160.0 12200.0 0.33 214960.0 -8180.0 -0.21 0.083 0.2148 1610 SPBio_001745 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H08 compound treatment 226440.0 7480.0 0.2 209560.0 -13600.0 -0.35 -0.1031 -0.2585 2527 SPBio_001746 COP(=S)(OC)Oc1ccc(Sc2ccc(OP(=S)(OC)OC)cc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H09 compound treatment 225480.0 6520.0 0.17 248960.0 25800.0 0.66 0.5872 0.8646 1014978 SPBio_001747 OCC(O)C(O)C(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H10 compound treatment 229560.0 10600.0 0.28 232960.0 9820.0 0.25 0.3764 0.9981 2530 SPBio_001748 CCCSP(=O)(OCC)SCCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H11 compound treatment 252400.0 33400.0 0.89 241120.0 18000.0 0.46 0.9537 0.9518 1003823 SPBio_001749 Cc1occc(=O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H12 compound treatment 250040.0 31100.0 0.83 270320.0 47200.0 1.2 1.4342 0.9837 2532 SPBio_001750 CC(C)(C)c1ccc(OC2CCCCC2OS(=O)OCC#C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H13 compound treatment 247200.0 28200.0 0.75 256480.0 33300.0 0.85 1.1319 0.9983 1052459 SPBio_001751 COc1c2ccoc2cc3oc(C)cc(=O)c13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H14 compound treatment 245200.0 26200.0 0.7 263320.0 40200.0 1.02 1.2171 0.983 2491 SPBio_001752 COC(=O)c1c(Cl)c(Cl)c(C(=O)OC)c(Cl)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H15 compound treatment 222640.0 3680.0 0.1 254960.0 31800.0 0.81 0.6415 0.7872 2069297 SPBio_001753 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H16 compound treatment 224320.0 5360.0 0.14 252000.0 28900.0 0.73 0.62 0.8293 2492 SPBio_001754 CC(C)Nc1nc(Cl)nc(NC(C)C)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H17 compound treatment 215000.0 -3960.0 -0.11 250080.0 26900.0 0.68 0.4097 0.5912 470 SPBio_001755 OC(=O)CCCc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H18 compound treatment 228040.0 9080.0 0.24 215880.0 -7260.0 -0.18 0.0407 0.1336 2493 SPBio_001756 CCC(=O)Nc1ccc(Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H19 compound treatment 212440.0 -6520.0 -0.17 204400.0 -18700.0 -0.48 -0.4598 -0.9065 1000133 SPBio_001757 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H20 compound treatment 215040.0 -3920.0 -0.1 215040.0 -8100.0 -0.21 -0.2195 -0.9504 2494 SPBio_001758 CCNc1nc(Cl)nc(NCC)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H21 compound treatment 233840.0 14900.0 0.4 230200.0 7060.0 0.18 0.4075 0.9356 2060499 SPBio_001759 OC[C@H]1O[C@@H](Oc2cc(O)c3c(=O)cc(oc3c2)c4ccc(O)cc4)[C@H](O[C@@H]5OC[C@](O)(CO)[C@H]5O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H22 compound treatment 222600.0 3640.0 0.1 227720.0 4580.0 0.12 0.151 0.996 2495 SPBio_001760 CCNc1nc(Cl)nc(NC(C)C)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H23 mock treatment 238080.0 19100.0 0.51 199080.0 -24100.0 -0.61 -0.0721 -0.0905 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 H24 mock treatment 191360.0 -27600.0 -0.74 220600.0 -2540.0 -0.06 -0.566 -0.7663 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I01 mock treatment 205360.0 -13600.0 -0.36 237600.0 14500.0 0.37 0.0036 0.007 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I02 mock treatment 199480.0 -19500.0 -0.52 217320.0 -5820.0 -0.15 -0.4719 -0.8739 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I03 compound treatment 226960.0 8000.0 0.21 208640.0 -14500.0 -0.37 -0.1099 -0.2579 2060321 SPBio_001761 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4c(=O)cc(oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I04 compound treatment 167320.0 -51600.0 -1.38 145200.0 -77900.0 -1.98 -2.3749 -0.9842 2060201 SPBio_001762 CC(=O)OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I05 compound treatment 252840.0 33900.0 0.9 218040.0 -5100.0 -0.13 0.5471 0.5994 3173485 SPBio_001763 OC[C@H]1O[C@H](Oc2cccc3[C@H]([C@@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(=O)O)c8cc(cc(O)c8C(=O)c23)C(=O)O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I06 compound treatment 126880.0 -92100.0 -2.46 206280.0 -16900.0 -0.43 -2.0391 -0.8182 2069229 SPBio_001764 Oc1ccc2oc3ccccc3c(=O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I07 compound treatment 209680.0 -9280.0 -0.25 236400.0 13300.0 0.34 0.0635 0.1518 2060342 SPBio_001765 O[C@@H]1[C@H](Oc2cc(O)ccc2C1=O)c3cc(O)c(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I08 compound treatment 140920.0 -78000.0 -2.08 189040.0 -34100.0 -0.87 -2.0844 -0.9247 2060279 SPBio_001766 CC(=O)OC1CC[C@@]2(C)C(CC[C@]3(C)C2CCC4C5CC(C)(C)CCC5(CC[C@]43C)C(=O)O)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I09 compound treatment 211520.0 -7440.0 -0.2 217400.0 -5740.0 -0.15 -0.2435 -0.9887 2060442 SPBio_001767 CCC(N)C(O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I10 compound treatment 175160.0 -43800.0 -1.17 200760.0 -22400.0 -0.57 -1.2281 -0.9454 2069285 SPBio_001768 CCCCCC(=O)Cc1cc(O)cc(O)c1C(=O)Oc2cc(CC(=O)CCCCC)c(C(=O)O)c(OC)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I11 compound treatment 233840.0 14900.0 0.4 242440.0 19300.0 0.49 0.6276 0.9945 2060343 SPBio_001769 CCCc1occc(=O)c1/C=C/O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I12 compound treatment 231760.0 12800.0 0.34 263040.0 39900.0 1.01 0.9587 0.8957 2524 SPBio_001770 COP(=O)(NC(=O)C)SC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I13 compound treatment 220080.0 1120.0 0.03 229080.0 5940.0 0.15 0.1279 0.8312 2060303 SPBio_001771 Cc1occc(=O)c1/C=C/O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I14 compound treatment 218800.0 -157.0 0.0 212120.0 -11000.0 -0.28 -0.2011 -0.7176 2528 SPBio_001772 CNC(=O)Oc1cccc2OC(C)(C)Oc21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I15 compound treatment 20080.0 -199000.0 -5.3 21320.0 -202000.0 -5.13 -7.3781 -0.9999 1000697 SPBio_001773 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(O[C@@H]4O[C@@H]5CO[C@H](OC5[C@H](O)[C@H]4O)c6cccs6)c7cc8OCOc8cc27 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I16 compound treatment 158480.0 -60500.0 -1.61 62720.0 -160000.0 -4.08 -4.0245 -0.9175 2060192 SPBio_001774 CC1(C)CC2C1CCC3(C)CCCC2(O)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I17 compound treatment 224360.0 5400.0 0.14 248720.0 25600.0 0.65 0.5617 0.8433 1835 SPBio_001775 CCCc1nn(C)c2c(=O)[nH]c(nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I18 compound treatment 217320.0 -1640.0 -0.04 229120.0 5980.0 0.15 0.0766 0.4845 3079231 SPBio_001776 CC1(C)O[C@H]2CC(=O)OC[C@@]23[C@H]1CC(=O)[C@]4(C)[C@@H]3CC[C@@]5(C)[C@@H](OC(=O)[C@H]6O[C@]654)c7ccoc7 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I19 compound treatment 17040.0 -202000.0 -5.38 17480.0 -206000.0 -5.23 -7.5045 -0.9999 2060453 SPBio_001777 Clc1c(Cl)c(C#N)c(Cl)c(C#N)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I20 compound treatment 209520.0 -9440.0 -0.25 204080.0 -19100.0 -0.48 -0.5206 -0.9534 1393 SPBio_001778 CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I21 compound treatment 224800.0 5840.0 0.16 211000.0 -12100.0 -0.31 -0.1082 -0.3127 2060298 SPBio_001779 CCCCCC1C(CC(=O)O)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I22 compound treatment 205080.0 -13900.0 -0.37 225600.0 2460.0 0.06 -0.2174 -0.5795 3055569 SPBio_001780 OCc1cccnc1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I23 mock treatment 214200.0 -4760.0 -0.13 209440.0 -13700.0 -0.35 -0.336 -0.9063 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 I24 mock treatment 203600.0 -15400.0 -0.41 220960.0 -2180.0 -0.06 -0.3288 -0.7957 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J01 mock treatment 204040.0 -14900.0 -0.4 239680.0 16500.0 0.42 0.0161 0.0278 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J02 mock treatment 217960.0 -997.0 -0.03 219120.0 -4020.0 -0.1 -0.0911 -0.8622 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J03 compound treatment 170280.0 -48700.0 -1.3 170240.0 -52900.0 -1.35 -1.8689 -0.9998 2060362 SPBio_001781 COc1ccc(cc1)c2c(OC)c3c(OC)c4C=CC(C)(C)Oc4cc3oc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J04 compound treatment 232320.0 13400.0 0.36 243240.0 20100.0 0.51 0.6133 0.9845 2497 SPBio_001782 CNC(=O)N(C)c1nnc(s1)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J05 compound treatment 240360.0 21400.0 0.57 228120.0 4980.0 0.13 0.493 0.8434 2060104 SPBio_001783 COc1cc(C)c2c(=O)c3c(O)cc(O)cc3oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J06 compound treatment 225840.0 6880.0 0.18 289320.0 66200.0 1.68 1.3196 0.7796 2498 SPBio_001784 COc1c(Cl)ccc(Cl)c1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J07 compound treatment 219600.0 643.0 0.02 236680.0 13500.0 0.34 0.2555 0.7414 1029490 SPBio_001785 COc1cc(O)c(C)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J08 compound treatment 210880.0 -8080.0 -0.22 231800.0 8660.0 0.22 0.0034 0.011 2499 SPBio_001786 CCCCN(CC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J09 compound treatment 216200.0 -2760.0 -0.07 247720.0 24600.0 0.62 0.3899 0.6197 1060118 SPBio_001787 COc1cc(OC)c2c(=O)c(OC)c(oc2c1)c3ccc(OC)c(OC)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J10 compound treatment 226960.0 8000.0 0.21 251560.0 28400.0 0.72 0.6618 0.8784 2500 SPBio_001788 COc1nc(NC(C)C)nc(NC(C)C)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J11 compound treatment 222920.0 3960.0 0.11 248800.0 25700.0 0.65 0.536 0.8111 2542 SPBio_001789 CCCCOC(=O)c1ccccc1C(=O)OCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J12 compound treatment 231280.0 12300.0 0.33 298280.0 75100.0 1.91 1.5833 0.8167 2501 SPBio_001790 CCc1cccc(C)c1N(C(C)COC)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J13 compound treatment 20760.0 -198000.0 -5.28 24920.0 -198000.0 -5.04 -7.3006 -0.9997 2060080 SPBio_001791 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6CC4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J14 compound treatment 193680.0 -25300.0 -0.67 248440.0 25300.0 0.64 -0.0217 -0.0233 2502 SPBio_001792 Clc1cccc(Cl)c1C#N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J15 compound treatment 233480.0 14500.0 0.39 229280.0 6140.0 0.16 0.3842 0.9202 1471 SPBio_001793 CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J16 compound treatment 222560.0 3600.0 0.1 261160.0 38000.0 0.97 0.7515 0.7736 2503 SPBio_001794 CSc1nc(NC(C)C)nc(NC(C)C)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J17 compound treatment 229040.0 10100.0 0.27 238560.0 15400.0 0.39 0.4673 0.9831 832 SPBio_001795 CCCn1c(=O)n(CCC)c2[nH]c(nc2c1=O)C3CCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J18 compound treatment 234720.0 15800.0 0.42 251040.0 27900.0 0.71 0.7988 0.9688 2504 SPBio_001796 CCCN(CCC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J19 compound treatment 16880.0 -202000.0 -5.39 18520.0 -205000.0 -5.2 -7.4888 -0.9998 3198539 SPBio_001797 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(\C)/C(=O)N)(OC5(C)C)C6=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J20 compound treatment 236840.0 17900.0 0.48 217040.0 -6100.0 -0.16 0.2274 0.4536 2505 SPBio_001798 CC(C)N1C(=O)c2ccccc2NS1(=O)=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J21 compound treatment 236440.0 17500.0 0.47 221560.0 -1580.0 -0.04 0.3012 0.6437 2069318 SPBio_001799 C[C@@H](NC(=O)/C(=C\c1ccc(O)c(O)c1)/C#N)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J22 compound treatment 193160.0 -25800.0 -0.69 208080.0 -15100.0 -0.38 -0.7572 -0.9618 2537 SPBio_001800 COc1ccc(cc1)C(c2ccc(OC)cc2)C(Cl)(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J23 mock treatment 230720.0 11800.0 0.31 219240.0 -3900.0 -0.1 0.1516 0.4609 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 J24 mock treatment 231560.0 12600.0 0.34 235680.0 12500.0 0.32 0.463 0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K01 mock treatment 177480.0 -41500.0 -1.11 232320.0 9180.0 0.23 -0.617 -0.5459 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K02 mock treatment 329640.0 111000.0 2.95 214560.0 -8580.0 -0.22 1.9324 0.653 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K03 compound treatment 16240.0 -203000.0 -5.4 17280.0 -206000.0 -5.23 -7.5231 -0.9999 2060271 SPBio_001801 CCC(C)C(=O)c1c(O)c(C)c2oc3c(C)c(O)c(C(=O)C(C)CC)c(O)c3c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K04 compound treatment 215560.0 -3400.0 -0.09 224080.0 938.0 0.02 -0.0472 -0.5038 1048 SPBio_001802 CCn1cc(C(=O)O)c(=O)c2cc(F)c(nc12)N3CCNCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K05 compound treatment 64480.0 -154000.0 -4.12 104800.0 -118000.0 -3.01 -5.0401 -0.9881 1386109 SPBio_001803 Oc1ccc2c(=O)c(O)c(oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K06 compound treatment 13240.0 -206000.0 -5.48 16760.0 -206000.0 -5.25 -7.589 -0.9998 709 SPBio_001804 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K07 compound treatment 199840.0 -19100.0 -0.51 206040.0 -17100.0 -0.43 -0.6679 -0.9969 907120 SPBio_001805 CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K08 compound treatment 206680.0 -12300.0 -0.33 264200.0 41100.0 1.04 0.5067 0.4632 744 SPBio_001806 Cn1cnc2[nH]c(=O)n(C)c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K09 compound treatment 147600.0 -71400.0 -1.9 142720.0 -80400.0 -2.04 -2.7912 -0.9994 2060459 SPBio_001807 OC[C@H]1OC2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K10 compound treatment 201920.0 -17000.0 -0.45 277160.0 54000.0 1.37 0.65 0.4493 1416 SPBio_001808 Cn1c(=O)n(C)c2[nH]c(nc2c1=O)C3CCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K11 compound treatment 224880.0 5920.0 0.16 232480.0 9340.0 0.24 0.2796 0.9804 1001314 SPBio_001809 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)[C@@H]4N[C@@H](COCCOC)O[C@H]([C@H]4C)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K12 compound treatment 223160.0 4200.0 0.11 280880.0 57700.0 1.47 1.1173 0.7589 1505 SPBio_001810 CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K13 compound treatment 210280.0 -8680.0 -0.23 230560.0 7420.0 0.19 -0.0302 -0.1013 3474314 SPBio_001811 CN1CCCCC1C(=O)Nc2c(C)cccc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K14 compound treatment 208560.0 -10400.0 -0.28 216840.0 -6300.0 -0.16 -0.3093 -0.9661 1587004 SPBio_001812 COc1ccc(cc1)C2Sc3ccccc3N(CCN(C)C)C(=O)C2OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K15 compound treatment 226840.0 7880.0 0.21 221240.0 -1900.0 -0.05 0.1144 0.5305 2060476 SPBio_001813 C[C@H]1[C@@H]2CCC(=C3[C@@H]([C@H]2OC1=O)C(=CC3=O)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K16 compound treatment 196000.0 -23000.0 -0.61 257800.0 34700.0 0.88 0.1903 0.1774 4362 SPBio_001814 CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K17 compound treatment 120680.0 -98300.0 -2.62 171800.0 -51300.0 -1.31 -2.7759 -0.9482 1095093 SPBio_001815 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K18 compound treatment 192400.0 -26600.0 -0.71 218520.0 -4620.0 -0.12 -0.5838 -0.8134 80 SPBio_001816 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K19 compound treatment 202320.0 -16600.0 -0.44 249480.0 26300.0 0.67 0.1599 0.199 1101055 SPBio_001817 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K20 compound treatment 198720.0 -20200.0 -0.54 225120.0 1980.0 0.05 -0.346 -0.6384 3173239 SPBio_001818 CC(N/C(=N/C#N)/Nc1ccncc1)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K21 compound treatment 35520.0 -183000.0 -4.89 38560.0 -185000.0 -4.69 -6.777 -0.9998 2060432 SPBio_001819 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)cc5cc4Cn3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K22 compound treatment 170960.0 -48000.0 -1.28 182400.0 -40700.0 -1.04 -1.6374 -0.9945 1000056 SPBio_001820 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K23 mock treatment 196000.0 -23000.0 -0.61 206560.0 -16600.0 -0.42 -0.731 -0.9834 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 K24 mock treatment 208720.0 -10200.0 -0.27 234360.0 11200.0 0.29 0.0087 0.022 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L01 mock treatment 193960.0 -25000.0 -0.67 262520.0 39400.0 1.0 0.2367 0.1968 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L02 mock treatment 223480.0 4520.0 0.12 224720.0 1580.0 0.04 0.1136 0.8941 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L03 compound treatment 245040.0 26100.0 0.7 250680.0 27500.0 0.7 0.9869 1.0 3079366 SPBio_001821 O[C@@H]1[C@H]2COC(O2)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L04 compound treatment 22920.0 -196000.0 -5.23 21240.0 -202000.0 -5.13 -7.326 -1.0 2538 SPBio_001822 ClC1C=CC2C1C3(Cl)C(=C(Cl)C2(Cl)C3(Cl)Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L05 compound treatment 232760.0 13800.0 0.37 338560.0 115000.0 2.93 2.3354 0.7896 1516 SPBio_001823 Nc1c2CCCCc2nc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L06 compound treatment 35160.0 -184000.0 -4.9 98040.0 -125000.0 -3.18 -5.7144 -0.9781 2539 SPBio_001824 CC1(C)C2(Cl)C(Cl)C1(Cl)C(Cl)(C(Cl)Cl)C(Cl)C2Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L07 compound treatment 17600.0 -201000.0 -5.37 92880.0 -130000.0 -3.31 -6.1383 -0.9731 26 SPBio_001825 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L08 compound treatment 25440.0 -194000.0 -5.16 43440.0 -180000.0 -4.57 -6.8793 -0.9982 2541 SPBio_001826 ClC1=C(Cl)C2(Cl)C3COS(=O)OCC3C1(Cl)C2(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L09 compound treatment 239320.0 20400.0 0.54 244880.0 21700.0 0.55 0.7747 1.0 690 SPBio_001827 CC(C)NCC(O)COc1ccccc1CC=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L10 compound treatment 23480.0 -195000.0 -5.21 29800.0 -193000.0 -4.92 -7.1615 -0.9996 2540 SPBio_001828 ClC1=C(Cl)C2(Cl)C3C4CC(C=C4)C3C1(Cl)C2(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L11 compound treatment 158560.0 -60400.0 -1.61 188080.0 -35100.0 -0.89 -1.7691 -0.9611 1395 SPBio_001829 CC(COc1ccccc1)N(CCCl)Cc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L12 compound treatment 195000.0 -24000.0 -0.64 254240.0 31100.0 0.79 0.1074 0.1057 2060152 SPBio_001830 CC(=O)O[C@@H]1CC2C(C)(C)C=CC(=O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L13 compound treatment 266080.0 47100.0 1.26 244240.0 21100.0 0.54 1.2677 0.928 74 SPBio_001831 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L14 compound treatment 243800.0 24800.0 0.66 222960.0 -183.0 0.0 0.4651 0.7021 3198541 SPBio_001832 CC(CCC=C(C)C)C1CC[C@@]2(C)C3=C(CC[C@]12C)C4(C)CC[C@H](OC(=O)C)C(C)(C)C4CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L15 compound treatment 197920.0 -21000.0 -0.56 264360.0 41200.0 1.05 0.3444 0.2898 907089 SPBio_001833 Cn1c(=O)n(C)c2ncn(CCCl)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L16 compound treatment 23120.0 -196000.0 -5.22 75480.0 -148000.0 -3.75 -6.347 -0.9869 2060174 SPBio_001834 CC(=CCc1c2OC(C)(C)C=Cc2c(O)c3c(=O)c(O)c(oc13)c4ccccc4)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L17 compound treatment 207720.0 -11200.0 -0.3 273680.0 50500.0 1.28 0.6968 0.5281 352677 SPBio_001835 COc1ccccc1N2CCNCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L18 compound treatment 232880.0 13900.0 0.37 270720.0 47600.0 1.21 1.1179 0.8834 3173763 SPBio_001836 O[C@@H]1C[C@](O)(C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H]1O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L19 compound treatment 201560.0 -17400.0 -0.46 258840.0 35700.0 0.91 0.3138 0.3079 718 SPBio_001837 Cn1c(=O)n(C)c2ncn(CCO)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L20 compound treatment 298560.0 79600.0 2.12 220400.0 -2740.0 -0.07 1.4515 0.6835 1171 SPBio_001838 CC(=O)Oc1ccccc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L21 compound treatment 202640.0 -16300.0 -0.44 230600.0 7460.0 0.19 -0.1735 -0.3657 1865 SPBio_001839 Clc1cccc(Nc2nnc(c3ccccc3)c4ccccc24)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L22 compound treatment 181320.0 -37600.0 -1.0 181400.0 -41700.0 -1.06 -1.4601 -0.9996 2060217 SPBio_001840 COc1c(ccc2OC(C)(C)CCc12)C3COc4cc5OC(C)(C)C(O)Cc5cc4C3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L23 mock treatment 206800.0 -12200.0 -0.32 208600.0 -14500.0 -0.37 -0.4907 -0.9978 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 L24 mock treatment 196920.0 -22000.0 -0.59 216080.0 -7060.0 -0.18 -0.5424 -0.8829 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M01 mock treatment 196080.0 -22900.0 -0.61 249840.0 26700.0 0.68 0.0487 0.0534 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M02 mock treatment 198120.0 -20800.0 -0.56 230520.0 7380.0 0.19 -0.2602 -0.4437 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M03 compound treatment 175880.0 -43100.0 -1.15 198280.0 -24900.0 -0.63 -1.2591 -0.9604 1091368 SPBio_001841 CNc1ccccc1C(=O)N2CCc3c([nH]c4ccccc34)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M04 compound treatment 205200.0 -13800.0 -0.37 217720.0 -5420.0 -0.14 -0.3569 -0.9107 918 SPBio_001842 CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M05 compound treatment 206480.0 -12500.0 -0.33 207480.0 -15700.0 -0.4 -0.5168 -0.996 1015899 SPBio_001843 NCC(=O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M06 compound treatment 88320.0 -131000.0 -3.48 96120.0 -127000.0 -3.23 -4.7467 -0.9993 693 SPBio_001844 CCN(CC)CCOc1ccc-2c(c1)C(=O)c3cc(OCCN(CC)CC)ccc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M07 compound treatment 202880.0 -16100.0 -0.43 230920.0 7780.0 0.2 -0.1633 -0.3459 1001204 SPBio_001845 COc1ccc(cc1)C(=O)CC(=O)c2ccc(cc2)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M08 compound treatment 160320.0 -58600.0 -1.56 185080.0 -38100.0 -0.97 -1.7898 -0.9734 2069286 SPBio_001846 CC(C)C(C)/C=C/C(C)[C@H]1CCC2C3=CCC4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M09 compound treatment 198640.0 -20300.0 -0.54 223040.0 -103.0 0.0 -0.3849 -0.7105 2060486 SPBio_001847 CC(=O)Oc1ccccc1C(=O)Oc2ccccc2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M10 compound treatment 15120.0 -204000.0 -5.43 28200.0 -195000.0 -4.96 -7.3479 -0.9989 3054523 SPBio_001848 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2[C@H]1C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M11 compound treatment 54560.0 -164000.0 -4.38 67040.0 -156000.0 -3.97 -5.906 -0.9988 1000656 SPBio_001849 OC1=C([C@H]2CC[C@@H](CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M12 compound treatment 206640.0 -12300.0 -0.33 230360.0 7220.0 0.18 -0.1024 -0.2723 3198536 SPBio_001850 COc1ccc2C[C@H]3N(C)CC[C@]4([C@H]5Oc1c24)C3=CC[C@@H]5O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M13 compound treatment 211840.0 -7120.0 -0.19 218360.0 -4780.0 -0.12 -0.2202 -0.9769 2060416 SPBio_001851 Sc1nc2ccccc2s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M14 compound treatment 197120.0 -21800.0 -0.58 238240.0 15100.0 0.38 -0.1403 -0.2011 1014978 SPBio_001852 OCC(O)C(O)C(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M15 compound treatment 207440.0 -11500.0 -0.31 240400.0 17300.0 0.44 0.0931 0.1739 3079223 SPBio_001853 Cl.NCCS 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M16 compound treatment 207000.0 -12000.0 -0.32 233480.0 10300.0 0.26 -0.0396 -0.0958 3079232 SPBio_001854 COc1ccc2c(=O)ccoc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M17 compound treatment 200680.0 -18300.0 -0.49 237760.0 14600.0 0.37 -0.0818 -0.1334 3172732 SPBio_001855 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M18 compound treatment 136960.0 -82000.0 -2.19 147720.0 -75400.0 -1.92 -2.902 -0.9979 3198537 SPBio_001856 CC(C)c1c(O)ccc2c1CCC3C(C)(CCCC32C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M19 compound treatment 193040.0 -25900.0 -0.69 211840.0 -11300.0 -0.29 -0.6918 -0.9244 907181 SPBio_001857 NC(=N)NC(=O)c1nc(Cl)c(nc1N)N2CCCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M20 compound treatment 168800.0 -50200.0 -1.34 206920.0 -16200.0 -0.41 -1.2373 -0.8841 1049467 SPBio_001858 COC(=O)c1c(C)cc(OC(=O)c2c(C)cc(O)c(C=O)c2O)c(C)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M21 compound treatment 182360.0 -36600.0 -0.98 216960.0 -6180.0 -0.16 -0.8011 -0.8106 1734308 SPBio_001859 Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M22 compound treatment 183920.0 -35000.0 -0.93 204040.0 -19100.0 -0.49 -1.004 -0.9536 2069239 SPBio_001860 Cc1cc(O)c2C(=O)c3c(O)c(C)cc(O)c3C(=O)c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M23 mock treatment 211360.0 -7600.0 -0.2 207040.0 -16100.0 -0.41 -0.4327 -0.9473 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 M24 mock treatment 192680.0 -26300.0 -0.7 215040.0 -8100.0 -0.21 -0.6411 -0.8779 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N01 mock treatment 211360.0 -7600.0 -0.2 249080.0 25900.0 0.66 0.3231 0.4683 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N02 mock treatment 220800.0 1840.0 0.05 228440.0 5300.0 0.13 0.13 0.9066 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N03 compound treatment 210800.0 -8160.0 -0.22 245520.0 22400.0 0.57 0.2485 0.408 1055442 SPBio_001861 Nc1nc(O)c2nc(cnc2n1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N04 compound treatment 208160.0 -10800.0 -0.29 233440.0 10300.0 0.26 -0.0184 -0.0473 2060172 SPBio_001862 CC1(C)CC2C1CCC3(CBr)CCC4C(CC(=O)O)C(=O)OC24C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N05 compound treatment 207200.0 -11800.0 -0.31 232720.0 9580.0 0.24 -0.0495 -0.1246 2060299 SPBio_001863 CC1(C)CC2/C(=C/C=C/C(C)(O)CCC21O)/CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N06 compound treatment 206520.0 -12400.0 -0.33 231440.0 8300.0 0.21 -0.0853 -0.217 1019872 SPBio_001864 COc1cc2COC(=O)c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N07 compound treatment 162600.0 -56400.0 -1.5 207640.0 -15500.0 -0.39 -1.3412 -0.8634 2069306 SPBio_001865 C[C@@]12CCC3C(CCC4=CC(=O)C=C[C@]34C)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N08 compound treatment 200920.0 -18000.0 -0.48 222400.0 -743.0 -0.02 -0.3534 -0.7343 2060193 SPBio_001866 CC1(C)C2CC1C(=C)C(N)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N09 compound treatment 203880.0 -15100.0 -0.4 246800.0 23700.0 0.6 0.1411 0.195 3173755 SPBio_001867 C[C@@]12CC(=O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N10 compound treatment 217560.0 -1400.0 -0.04 244400.0 21300.0 0.54 0.3559 0.6568 2060191 SPBio_001868 CC1(C)CC2C1CCC(=O)C(CCC2=C)C3CC(=O)OC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N11 compound treatment 204840.0 -14100.0 -0.38 241280.0 18100.0 0.46 0.06 0.1007 3177324 SPBio_001869 C[C@@]12CC(=O)C3C(CC[C@@H]4C[C@H](O)CC[C@@]43C)C2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N12 compound treatment 205560.0 -13400.0 -0.36 240840.0 17700.0 0.45 0.0656 0.1142 1114909 SPBio_001870 COc1cc(CC=C)ccc1OC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N13 compound treatment 218880.0 -76.8 0.0 264840.0 41700.0 1.06 0.7482 0.7057 2069240 SPBio_001871 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CC[C@@H]4C[C@@H](CC[C@]4(C)C3C(=O)C[C@@]21C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N14 compound treatment 217680.0 -1280.0 -0.03 229640.0 6500.0 0.17 0.0927 0.5498 3054634 SPBio_001872 COc1c(CC=C(C)C)c2OC(C)(C)C=Cc2c3oc(=O)c(c(O)c13)c4ccc(O)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N15 compound treatment 165400.0 -53600.0 -1.43 205720.0 -17400.0 -0.44 -1.323 -0.8849 2060261 SPBio_001873 CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]2CCC4[C@@]5(C)CCCC(C)(C)C5[C@@H](O)C[C@]43C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N16 compound treatment 225000.0 6040.0 0.16 278760.0 55600.0 1.41 1.1139 0.7826 3174602 SPBio_001874 O=c1[nH]cnc2nc[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N17 compound treatment 190600.0 -28400.0 -0.76 237320.0 14200.0 0.36 -0.2797 -0.3339 1506 SPBio_001875 OCc1cc(=O)c(O)co1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N18 compound treatment 168480.0 -50500.0 -1.35 210320.0 -12800.0 -0.33 -1.1822 -0.8537 3174484 SPBio_001876 C[C@@]12CCC3C(CC[C@H]4C[C@@H](O)CC[C@@]43C)C2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N19 compound treatment 205840.0 -13100.0 -0.35 239560.0 16400.0 0.42 0.0479 0.0879 2060349 SPBio_001877 CCC[C@H]1CC2=C(C[C@@H](CC)CC3=C1C(=O)OC3=O)C(=O)OC2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N20 compound treatment 210040.0 -8920.0 -0.24 207760.0 -15400.0 -0.39 -0.4447 -0.9715 2060302 SPBio_001878 CC(C)CCC[C@@H](C)CCC[C@@H](C)CC/C(=C/CO)/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N21 compound treatment 15720.0 -203000.0 -5.42 16800.0 -206000.0 -5.25 -7.5416 -0.9999 3198540 SPBio_001879 COC(=O)/C(=C/CC1(OC(C)(C)C2CC3C=C4C(=O)c5cc6C7CC(C)(CCC7=C(C)C)Oc6c(CCC(C)(C)Cl)c5OC241)C3=O)/C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N22 compound treatment 217960.0 -997.0 -0.03 209440.0 -13700.0 -0.35 -0.2652 -0.7588 3174493 SPBio_001880 N[C@H]([C@@H](O)[C@H](O)[C@H](O)CO)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N23 mock treatment 209240.0 -9720.0 -0.26 207440.0 -15700.0 -0.4 -0.4655 -0.9781 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 N24 mock treatment 221760.0 2800.0 0.07 217840.0 -5300.0 -0.13 -0.0425 -0.2756 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O01 mock treatment 226960.0 8000.0 0.21 240880.0 17700.0 0.45 0.4698 0.9416 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O02 mock treatment 234040.0 15100.0 0.4 223840.0 698.0 0.02 0.2969 0.7376 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O03 compound treatment 15000.0 -204000.0 -5.44 16760.0 -206000.0 -5.25 -7.5559 -0.9998 1000094 SPBio_001881 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O04 compound treatment 225440.0 6480.0 0.17 211760.0 -11400.0 -0.29 -0.0824 -0.2445 3079279 SPBio_001882 COC(=O)c1c(C)cc(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O05 compound treatment 11360.0 -208000.0 -5.54 19280.0 -204000.0 -5.18 -7.5792 -0.9995 2101 SPBio_001883 Oc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O06 compound treatment 219200.0 243.0 0.01 225360.0 2220.0 0.06 0.0445 0.7833 3055391 SPBio_001884 OC[C@H]1O[C@@H](Oc2cc(O)c3c(=O)cc(oc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O07 compound treatment 14160.0 -205000.0 -5.46 22120.0 -201000.0 -5.11 -7.4753 -0.9995 3480079 SPBio_001885 COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O08 compound treatment 207680.0 -11300.0 -0.3 290720.0 67600.0 1.72 1.0024 0.5746 3198538 SPBio_001886 COc1cc2OCOc2cc1c3coc4cc(OC)c(OC)cc4c3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O09 compound treatment 196880.0 -22100.0 -0.59 238280.0 15100.0 0.38 -0.1441 -0.2048 3177524 SPBio_001887 CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc2ccccc2)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O10 compound treatment 204760.0 -14200.0 -0.38 256080.0 32900.0 0.84 0.3245 0.3531 2060249 SPBio_001888 COc1ccc(cc1)c2coc3c(OC)c(O)ccc3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O11 compound treatment 225800.0 6840.0 0.18 260480.0 37300.0 0.95 0.8003 0.8279 1635 SPBio_001889 CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5nnn[nH]5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O12 compound treatment 230840.0 11900.0 0.32 309080.0 85900.0 2.19 1.7691 0.8013 3079280 SPBio_001890 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O13 compound treatment 275520.0 56600.0 1.51 320960.0 97800.0 2.49 2.8251 0.9713 1000155 SPBio_001891 C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O14 compound treatment 230440.0 11500.0 0.31 237000.0 13900.0 0.35 0.4656 0.9976 1002679 SPBio_001892 OCC(O)C(O)C(O)C(O)C(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O15 compound treatment 178120.0 -40800.0 -1.09 238080.0 14900.0 0.38 -0.5013 -0.4348 1606766 SPBio_001893 CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)c3ccccc3c4nnn[nH]4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O16 compound treatment 198320.0 -20600.0 -0.55 258440.0 35300.0 0.9 0.2456 0.2333 2060353 SPBio_001894 Cc1c(O)cc(O)c2c(=O)c(coc12)c3ccc(O)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O17 compound treatment 44800.0 -174000.0 -4.64 64480.0 -159000.0 -4.03 -6.1361 -0.9975 3059445 SPBio_001895 CCCCCCCCCCC[C@@H](C[C@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O18 compound treatment 37480.0 -181000.0 -4.84 183200.0 -39900.0 -1.02 -4.1396 -0.8373 2060132 SPBio_001896 CC1=CC(=O)C2C(C)(C)CCC[C@]2(C)[C@@]1(O)CCc3ccoc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O19 compound treatment 223080.0 4120.0 0.11 227080.0 3940.0 0.1 0.1485 0.9989 3480074 SPBio_001897 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O20 compound treatment 203080.0 -15900.0 -0.42 238960.0 15800.0 0.4 -0.0149 -0.0256 2060134 SPBio_001898 COc1cc2ccc(=O)oc2c3ccoc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O21 compound treatment 222320.0 3360.0 0.09 211280.0 -11900.0 -0.3 -0.1499 -0.4763 907463 SPBio_001899 Cc1nc2ccccn2c(=O)c1CCN3CCC(CC3)C(=O)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O22 compound treatment 236760.0 17800.0 0.47 216640.0 -6500.0 -0.17 0.2187 0.4352 2060220 SPBio_001900 CC/1[C@H]2C[C@@H](C\C1=N/O)C2(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O23 mock treatment 234640.0 15700.0 0.42 264280.0 41100.0 1.05 1.0353 0.9191 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 O24 mock treatment 211360.0 -7600.0 -0.2 245440.0 22300.0 0.57 0.2577 0.428 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P01 mock treatment 239080.0 20100.0 0.54 210240.0 -12900.0 -0.33 0.1474 0.2344 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P02 mock treatment 257600.0 38600.0 1.03 234360.0 11200.0 0.29 0.9302 0.8701 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P03 compound treatment 206600.0 -12400.0 -0.33 216080.0 -7060.0 -0.18 -0.3599 -0.9593 1087705 SPBio_001901 CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P04 compound treatment 231320.0 12400.0 0.33 342000.0 119000.0 3.02 2.3701 0.7796 290 SPBio_001902 CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)C)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P05 compound treatment 8840.0 -210000.0 -5.6 12760.0 -210000.0 -5.35 -7.7439 -0.9997 2543 SPBio_001903 CCCCCCCCCc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P06 compound treatment 176440.0 -42500.0 -1.13 272640.0 49500.0 1.26 0.0883 0.0522 2060293 SPBio_001904 C[C@@H]1CC[C@H]2C(C)(C)C3C[C@@]12CC[C@@]3(C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P07 compound treatment 102360.0 -117000.0 -3.11 174600.0 -48500.0 -1.23 -3.071 -0.9181 2069261 SPBio_001905 COc1cc2OCC3Oc4c5C=CC(C)(C)Oc5cc(O)c4C(=O)C3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P08 compound treatment 219640.0 683.0 0.02 279840.0 56700.0 1.44 1.0323 0.716 1305 SPBio_001906 CCOC(=O)O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccc(OC)cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P09 compound treatment 132600.0 -86400.0 -2.3 176280.0 -46900.0 -1.19 -2.4707 -0.953 2060403 SPBio_001907 COc1ccc(C2COc3cc(O)ccc3C2)c(OC)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P10 compound treatment 238240.0 19300.0 0.51 292200.0 69100.0 1.76 1.6052 0.8773 2325 SPBio_001908 NC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P11 compound treatment 229600.0 10600.0 0.28 263520.0 40400.0 1.03 0.9266 0.8699 3079389 SPBio_001909 COc1cc(OC)c(C(=O)c2ccc(O)cc2)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P12 compound treatment 216840.0 -2120.0 -0.06 293000.0 69900.0 1.78 1.2161 0.6843 2544 SPBio_001910 CCOCN(C(=O)CCl)c1c(C)cccc1CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P13 compound treatment 299360.0 80400.0 2.14 283600.0 60500.0 1.54 2.6028 0.9867 2060426 SPBio_001911 COc1c(O)cccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P14 compound treatment 242440.0 23500.0 0.63 335080.0 112000.0 2.85 2.4553 0.8425 1004713 SPBio_001912 CNc1ccccc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P15 compound treatment 239200.0 20200.0 0.54 248480.0 25300.0 0.64 0.8372 0.9961 1402956 SPBio_001913 CC(N)C(O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P16 compound treatment 145520.0 -73400.0 -1.96 204640.0 -18500.0 -0.47 -1.7172 -0.8527 1040795 SPBio_001914 COc1cccc(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P17 compound treatment 179920.0 -39000.0 -1.04 236840.0 13700.0 0.35 -0.4897 -0.4462 1010251 SPBio_001915 O=C(Nc1ccccc1)Nc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P18 compound treatment 191360.0 -27600.0 -0.74 314080.0 90900.0 2.31 1.1147 0.4594 2060417 SPBio_001916 CC(=C)C1Cc2c(O1)ccc(C(=O)O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P19 compound treatment 262920.0 44000.0 1.17 269800.0 46700.0 1.19 1.6677 1.0 2069279 SPBio_001917 CCC(C)C(NC)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P20 compound treatment 198600.0 -20400.0 -0.54 272640.0 49500.0 1.26 0.5061 0.3693 2060436 SPBio_001918 O=C(CCCCCCCCCCCCC1CCCC1)Nc2ccc(cc2)S(=O)(=O)c3ccc(NC(=O)CCCCCCCCCCCCC4CCCC4)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P21 compound treatment 127840.0 -91100.0 -2.43 175320.0 -47800.0 -1.22 -2.5777 -0.9488 2069262 SPBio_001919 COc1cc(/C=C/C=O)cc(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P22 compound treatment 204880.0 -14100.0 -0.38 234640.0 11500.0 0.29 -0.0587 -0.1233 2060448 SPBio_001920 COc1ccc2[C@H](O)[C@H](Cc3ccc(OC)c(OC)c3)COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P23 mock treatment 227880.0 8920.0 0.24 226000.0 2860.0 0.07 0.2196 0.8828 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2163 P24 mock treatment 222840.0 3880.0 0.1 242760.0 19600.0 0.5 0.4259 0.8361 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A01 mock treatment 228720.0 463.0 0.01 234000.0 20900.0 0.53 0.3852 0.7233 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A02 mock treatment 222080.0 -6180.0 -0.16 241400.0 28300.0 0.72 0.393 0.5318 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A03 compound treatment 221880.0 -6380.0 -0.17 247160.0 34100.0 0.87 0.4928 0.5578 1026119 SPBio_001921 COc1ccc(C(=O)O)c(O)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A04 compound treatment 106360.0 -122000.0 -3.25 148120.0 -64900.0 -1.65 -3.4658 -0.9507 1164875 SPBio_001922 Nc1nc2[nH]nnc2c(=O)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A05 compound treatment 24880.0 -203000.0 -5.42 27240.0 -186000.0 -4.72 -7.1753 -0.9976 2069278 SPBio_001923 Cc1cc(O)c(C=O)c(O)c1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A06 compound treatment 199120.0 -29100.0 -0.78 233680.0 20600.0 0.52 -0.1786 -0.1906 923 SPBio_001924 NC(=O)NC1NC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A07 compound treatment 199280.0 -29000.0 -0.77 233960.0 20900.0 0.53 -0.1706 -0.1819 3080393 SPBio_001925 COc1ccc(cc1)c2c(O)c3c(OC)c4CCC(C)(C)Oc4cc3oc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A08 compound treatment 208600.0 -19700.0 -0.52 257000.0 43900.0 1.12 0.4194 0.3398 692 SPBio_001926 CC(=O)Nc1nnc(s1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A09 compound treatment 164240.0 -64000.0 -1.71 223080.0 10000.0 0.25 -1.0268 -0.595 2069280 SPBio_001927 COc1cc(O)ccc1C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A10 compound treatment 217240.0 -11000.0 -0.29 255320.0 42300.0 1.07 0.552 0.4956 1714 SPBio_001928 CN(C)C(=N)NC(=N)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A11 compound treatment 211720.0 -16500.0 -0.44 254280.0 41200.0 1.05 0.4293 0.3776 2060335 SPBio_001929 Oc1ccc2C3Oc4cc5OCOc5cc4C3COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A12 compound treatment 224120.0 -4140.0 -0.11 246080.0 33000.0 0.84 0.5156 0.609 3221455 SPBio_001930 COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCc5cc(OC)c(OC)cc5C4Cc6ccc(OC)c(OC)c6)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A13 compound treatment 85680.0 -143000.0 -3.8 116040.0 -97000.0 -2.47 -4.4324 -0.9781 3198542 SPBio_001931 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(OC)c(c4cc(ccc4OC)c5cc(=O)c6c(OC)cc(OC)cc6o5)c3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A14 compound treatment 225600.0 -2660.0 -0.07 242920.0 29900.0 0.76 0.4867 0.6384 3064163 SPBio_001932 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A15 compound treatment 227080.0 -1180.0 -0.03 261840.0 48800.0 1.24 0.8548 0.689 3080394 SPBio_001933 COc1cc(OC)c2c(=O)c(c(C)oc2c1OC)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A16 compound treatment 231440.0 3180.0 0.08 256840.0 43800.0 1.11 0.8471 0.7588 1000042 SPBio_001934 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A17 compound treatment 170720.0 -57500.0 -1.53 205440.0 -7620.0 -0.19 -1.2218 -0.7902 2060054 SPBio_001935 CC(=O)OC(OC(=O)C)c1c(OC(=O)C)cc(C)c2C(=O)Oc3c(C)c(OC(=O)C)c4C(=O)OC(OC(=O)C)c4c3Oc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A18 compound treatment 222560.0 -5700.0 -0.15 248800.0 35700.0 0.91 0.5351 0.5808 807 SPBio_001936 CCCc1ncc(C[n+]2ccccc2C)c(N)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A19 compound treatment 223760.0 -4500.0 -0.12 272440.0 59400.0 1.51 0.9828 0.6489 3173626 SPBio_001937 CC(C)C(C)/C=C/C(C)C1CCC2C3=CC=C4C(C)(C)C(CCC4(C)C3CCC12C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A20 compound treatment 220240.0 -8020.0 -0.21 254360.0 41300.0 1.05 0.5913 0.5518 931 SPBio_001938 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A21 compound treatment 230760.0 2500.0 0.07 267000.0 53900.0 1.37 1.0169 0.7406 1082584 SPBio_001939 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(=C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A22 compound treatment 227320.0 -937.0 -0.02 260760.0 47700.0 1.21 0.8399 0.6924 3068956 SPBio_001940 NC(=NS(=O)(=O)c1ccc(N)cc1)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A23 mock treatment 221240.0 -7020.0 -0.19 250680.0 37600.0 0.96 0.544 0.5582 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 A24 mock treatment 238480.0 10200.0 0.27 231120.0 18100.0 0.46 0.5174 0.969 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B01 mock treatment 232320.0 4060.0 0.11 254800.0 41700.0 1.06 0.827 0.7753 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B02 mock treatment 200680.0 -27600.0 -0.74 240480.0 27400.0 0.7 -0.027 -0.0266 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B03 compound treatment 214280.0 -14000.0 -0.37 251640.0 38600.0 0.98 0.4301 0.4099 683 SPBio_001941 Cc1ncc([N+](=O)[O-])n1CCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B04 compound treatment 211280.0 -17000.0 -0.45 233800.0 20700.0 0.53 0.0528 0.0759 735 SPBio_001942 NNC(=O)c1ccncc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B05 compound treatment 200840.0 -27400.0 -0.73 225280.0 12200.0 0.31 -0.2972 -0.3742 1449 SPBio_001943 CN1[C@@H](CCC1=O)c2cccnc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B06 compound treatment 209560.0 -18700.0 -0.5 241080.0 28000.0 0.71 0.1512 0.1739 1008060 SPBio_001944 C1CCc2nnnn2CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B07 compound treatment 214720.0 -13500.0 -0.36 217960.0 4900.0 0.12 -0.1672 -0.4378 1402 SPBio_001945 CC[N+](C)(C)c1cccc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B08 compound treatment 220280.0 -7980.0 -0.21 231240.0 18200.0 0.46 0.1764 0.3468 1480 SPBio_001946 Clc1ccc2oc(=O)[nH]c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B09 compound treatment 203200.0 -25100.0 -0.67 228600.0 15500.0 0.4 -0.1931 -0.2487 1029858 SPBio_001947 NC(=N)NC(=N)N1CCOCC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B10 compound treatment 210200.0 -18100.0 -0.48 232960.0 19900.0 0.51 0.0173 0.0248 1054660 SPBio_001948 Cc1ncc([N+](=O)[O-])n1CC(O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B11 compound treatment 223200.0 -5060.0 -0.13 249600.0 36500.0 0.93 0.5616 0.5982 678 SPBio_001949 NCC(CC(=O)O)c1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B12 compound treatment 228360.0 103.0 0.0 225840.0 12800.0 0.32 0.2317 0.7131 869 SPBio_001950 CCC1(C)CC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B13 compound treatment 241400.0 13100.0 0.35 229440.0 16400.0 0.42 0.5422 0.9963 839 SPBio_001951 Nc1nc2n(COCCO)cnc2c(=O)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B14 compound treatment 221960.0 -6300.0 -0.17 241120.0 28100.0 0.71 0.3857 0.5263 997 SPBio_001952 NCc1ccc(cc1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B15 compound treatment 213040.0 -15200.0 -0.41 223200.0 10100.0 0.26 -0.1046 -0.2177 35 SPBio_001953 CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B16 compound treatment 196080.0 -32200.0 -0.86 235160.0 22100.0 0.56 -0.2093 -0.2041 399 SPBio_001954 Nc1nc2ccc(OC(F)(F)F)cc2s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B17 compound treatment 202400.0 -25900.0 -0.69 247880.0 34800.0 0.89 0.1385 0.1234 1090166 SPBio_001955 CN(C)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B18 compound treatment 192720.0 -35500.0 -0.95 224040.0 11000.0 0.28 -0.4726 -0.4785 3173466 SPBio_001956 [O-][N+](=O)c1ccc(/C=N/N2CC(=O)NC2=O)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B19 compound treatment 57800.0 -170000.0 -4.54 103120.0 -110000.0 -2.8 -5.1904 -0.9728 3188940 SPBio_001957 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2[C@H]1C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B20 compound treatment 218640.0 -9620.0 -0.26 263800.0 50700.0 1.29 0.7309 0.5557 776 SPBio_001958 NNc1nncc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B21 compound treatment 226200.0 -2060.0 -0.05 233520.0 20500.0 0.52 0.329 0.6291 1428 SPBio_001959 CC(C)NCC(O)COc1cccc2[nH]ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B22 compound treatment 263200.0 34900.0 0.93 261440.0 48400.0 1.23 1.5286 0.9906 3273 SPBio_001960 NNCCc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B23 mock treatment 234400.0 6140.0 0.16 249560.0 36500.0 0.93 0.772 0.8192 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 B24 mock treatment 244320.0 16100.0 0.43 247840.0 34800.0 0.88 0.9281 0.9446 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C01 mock treatment 221120.0 -7140.0 -0.19 235760.0 22700.0 0.58 0.2735 0.4501 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C02 mock treatment 226080.0 -2180.0 -0.06 214720.0 1660.0 0.04 -0.0112 -0.1568 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C03 compound treatment 212320.0 -15900.0 -0.42 234120.0 21100.0 0.54 0.0781 0.1143 2069342 SPBio_001961 COC1=CC(=O)C(=CC1=O)C(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C04 compound treatment 201360.0 -26900.0 -0.72 217800.0 4740.0 0.12 -0.4219 -0.5802 2898 SPBio_001962 Cc1cc2CCCS(=O)(=O)c2cc1S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C05 compound treatment 195240.0 -33000.0 -0.88 225560.0 12500.0 0.32 -0.3978 -0.425 2060428 SPBio_001963 CCOC(=O)C(=O)C1(Oc2cc(OC)cc(OC)c2C(=O)C1c3ccccc3)C(=O)OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C06 compound treatment 202240.0 -26000.0 -0.69 241040.0 28000.0 0.71 0.0125 0.0126 3188932 SPBio_001964 CCCCNc1ccc(cc1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C07 compound treatment 215000.0 -13300.0 -0.35 216360.0 3300.0 0.08 -0.1907 -0.5248 966 SPBio_001965 OC[C@@H]1OC(=O)[C@@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C08 compound treatment 195200.0 -33100.0 -0.88 232400.0 19300.0 0.49 -0.2756 -0.273 1131 SPBio_001966 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C09 compound treatment 120920.0 -107000.0 -2.86 148920.0 -64100.0 -1.63 -3.1769 -0.9645 1000247 SPBio_001967 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)N(C)C)c5c(O)c6C(=O)c7c(O)cccc7C(=O)c6cc5[C@H]1C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C10 compound treatment 198440.0 -29800.0 -0.79 217120.0 4060.0 0.1 -0.4892 -0.6102 878 SPBio_001968 CC(=O)NS(=O)(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C11 compound treatment 205320.0 -22900.0 -0.61 225800.0 12700.0 0.32 -0.2034 -0.294 1319 SPBio_001969 NCCCCN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C12 compound treatment 208720.0 -19500.0 -0.52 217000.0 3940.0 0.1 -0.2975 -0.5609 1507 SPBio_001970 CC(N)CCCC(C)(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C13 compound treatment 218400.0 -9860.0 -0.26 228760.0 15700.0 0.4 0.0964 0.2017 3173726 SPBio_001971 NNC(=O)c1ccncc1.Nc1ccc(C(=O)O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C14 compound treatment 205840.0 -22400.0 -0.6 239080.0 26000.0 0.66 0.0451 0.0506 1175 SPBio_001972 Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C15 compound treatment 211120.0 -17100.0 -0.46 210480.0 -2580.0 -0.07 -0.3695 -0.8005 914 SPBio_001973 OC[C@H]1O[C@@H](OC2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc24)[C@H](O)[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C16 compound treatment 181520.0 -46700.0 -1.25 202040.0 -11000.0 -0.28 -1.0793 -0.845 1079 SPBio_001974 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C17 compound treatment 206960.0 -21300.0 -0.57 231200.0 18100.0 0.46 -0.0754 -0.1031 768 SPBio_001975 C[N+](C)(C)CCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C18 compound treatment 171360.0 -56900.0 -1.52 203080.0 -9980.0 -0.25 -1.2522 -0.8141 3068957 SPBio_001976 OC[C@H]1O[C@H](CC1O)n2cc(I)c(=O)[nH]c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C19 compound treatment 218880.0 -9380.0 -0.25 229440.0 16400.0 0.42 0.1177 0.2423 3055573 SPBio_001977 OC[C@H]1OC([C@H](O)[C@@H]1O)n2cnc3c(=O)[nH]cnc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C20 compound treatment 212680.0 -15600.0 -0.42 223560.0 10500.0 0.27 -0.1049 -0.2126 3068958 SPBio_001978 CC(C)(CS)C(=O)N1CCC[C@@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C21 compound treatment 200440.0 -27800.0 -0.74 229400.0 16300.0 0.42 -0.2307 -0.2714 1193 SPBio_001979 CCOc1ccc(NC(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C22 compound treatment 223200.0 -5060.0 -0.13 223760.0 10700.0 0.27 0.097 0.3195 82 SPBio_001980 Nc1cc(nc(N)[n+]1[O-])N2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C23 mock treatment 192480.0 -35800.0 -0.95 209880.0 -3180.0 -0.08 -0.7317 -0.7644 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 C24 mock treatment 223000.0 -5260.0 -0.14 149600.0 -63500.0 -1.61 -1.2401 -0.7656 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D01 mock treatment 225000.0 -3260.0 -0.09 247880.0 34800.0 0.89 0.5646 0.6347 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D02 mock treatment 208840.0 -19400.0 -0.52 223800.0 10700.0 0.27 -0.173 -0.2956 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D03 compound treatment 217960.0 -10300.0 -0.27 223200.0 10100.0 0.26 -0.0119 -0.0315 715 SPBio_001981 COc1c2ccoc2c(OC)c3oc(C)cc(=O)c13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D04 compound treatment 209560.0 -18700.0 -0.5 240480.0 27400.0 0.7 0.1404 0.1639 1262 SPBio_001982 NC[C@H]1CC[C@@H](CC1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D05 compound treatment 212680.0 -15600.0 -0.42 244240.0 31200.0 0.79 0.2669 0.2982 1002029 SPBio_001983 CN(C)C/C=C(/c1ccc(Br)cc1)\c2cccnc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D06 compound treatment 202920.0 -25300.0 -0.68 235520.0 22500.0 0.57 -0.0739 -0.0836 718 SPBio_001984 Cn1c(=O)n(C)c2ncn(CCO)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D07 compound treatment 28760.0 -199000.0 -5.32 47560.0 -166000.0 -4.21 -6.7368 -0.9933 1451360 SPBio_001985 OC(C1CCNCC1)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D08 compound treatment 206280.0 -22000.0 -0.59 218360.0 5300.0 0.13 -0.3191 -0.5307 3069074 SPBio_001986 N[C@@H]1C[C@H]1c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D09 compound treatment 91840.0 -136000.0 -3.64 74160.0 -139000.0 -3.53 -5.0693 -0.9999 1921128 SPBio_001987 Cn1cnc([N+](=O)[O-])c1Sc2ncnc3nc[nH]c23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D10 compound treatment 181760.0 -46500.0 -1.24 181720.0 -31300.0 -0.8 -1.4401 -0.9772 3256 SPBio_001988 CCN(CCCc1ccccc1)CCCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D11 compound treatment 17760.0 -210000.0 -5.61 23680.0 -189000.0 -4.82 -7.3735 -0.9971 3069004 SPBio_001989 C[C@@]12CC[C@H]3[C@@H](CCC4=CCCC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D12 compound treatment 203680.0 -24600.0 -0.66 230280.0 17200.0 0.44 -0.1538 -0.1952 3069075 SPBio_001990 OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D13 compound treatment 216240.0 -12000.0 -0.32 255080.0 42000.0 1.07 0.5289 0.4742 3060090 SPBio_001991 NC(=N)N/N=C/c1c(Cl)cccc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D14 compound treatment 217680.0 -10600.0 -0.28 228320.0 15300.0 0.39 0.0749 0.1562 780 SPBio_001992 CC(C)NNC(=O)c1ccncc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D15 compound treatment 17120.0 -211000.0 -5.63 22080.0 -191000.0 -4.86 -7.4144 -0.9973 2038 SPBio_001993 CCN(CC)C(=S)SSC(=S)N(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D16 compound treatment 210920.0 -17300.0 -0.46 227160.0 14100.0 0.36 -0.0734 -0.1255 1256 SPBio_001994 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D17 compound treatment 199720.0 -28500.0 -0.76 224720.0 11700.0 0.3 -0.3284 -0.4022 2060486 SPBio_001995 CC(=O)Oc1ccccc1C(=O)Oc2ccccc2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D18 compound treatment 202000.0 -26300.0 -0.7 229960.0 16900.0 0.43 -0.1912 -0.2328 741 SPBio_001996 Cc1ccccc1OCC(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D19 compound treatment 207880.0 -20400.0 -0.54 222880.0 9820.0 0.25 -0.2077 -0.3473 1434 SPBio_001997 CN1CCN2C(C1)c3ccccc3Cc4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D20 compound treatment 191600.0 -36700.0 -0.98 221040.0 7980.0 0.2 -0.5477 -0.5487 1018627 SPBio_001998 NC(=N)NC(=N)NCCc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D21 compound treatment 142160.0 -86100.0 -2.3 140760.0 -72300.0 -1.84 -2.9232 -0.9939 440 SPBio_001999 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D22 compound treatment 203000.0 -25300.0 -0.67 220840.0 7780.0 0.2 -0.3363 -0.4792 1086 SPBio_002000 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(c1)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D23 mock treatment 206000.0 -22300.0 -0.59 222640.0 9580.0 0.24 -0.2474 -0.3857 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 D24 mock treatment 223760.0 -4500.0 -0.12 202400.0 -10700.0 -0.27 -0.2765 -0.9327 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E01 mock treatment 211280.0 -17000.0 -0.45 225920.0 12900.0 0.33 -0.0889 -0.1592 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E02 mock treatment 209000.0 -19300.0 -0.51 218520.0 5460.0 0.14 -0.2649 -0.4981 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E03 compound treatment 207200.0 -21100.0 -0.56 210920.0 -2140.0 -0.05 -0.4355 -0.7721 939 SPBio_002001 Cc1cccc(Nc2ccccc2C(=O)O)c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E04 compound treatment 211280.0 -17000.0 -0.45 225480.0 12400.0 0.32 -0.0968 -0.1754 944 SPBio_002002 Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E05 compound treatment 228680.0 423.0 0.01 241040.0 28000.0 0.71 0.511 0.7182 1668673 SPBio_002003 Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E06 compound treatment 204120.0 -24100.0 -0.64 349080.0 136000.0 3.46 1.9904 0.5658 3060 SPBio_002004 CC(C)(CO)[C@@H](O)C(=O)NCCCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E07 compound treatment 226880.0 -1380.0 -0.04 230920.0 17900.0 0.45 0.2951 0.6478 944 SPBio_002005 Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E08 compound treatment 225240.0 -3020.0 -0.08 239880.0 26800.0 0.68 0.4253 0.6194 1159 SPBio_002006 Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E09 compound treatment 223920.0 -4340.0 -0.12 226520.0 13500.0 0.34 0.1602 0.4435 2060488 SPBio_002007 CC(=CCC[C@@](C)(O)C=C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E10 compound treatment 185320.0 -42900.0 -1.14 221360.0 8300.0 0.21 -0.6603 -0.5672 3188934 SPBio_002008 C[C@@]12CC[C@H]3[C@@H](CCC4=C3CCC(=O)C4)[C@@H]2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E11 compound treatment 230800.0 2540.0 0.07 228000.0 14900.0 0.38 0.3165 0.8204 3198543 SPBio_002009 [Na+].Oc1ccccc1C(=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E12 compound treatment 274400.0 46100.0 1.23 284240.0 71200.0 1.81 2.1497 0.9823 1433 SPBio_002010 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E13 compound treatment 242160.0 13900.0 0.37 237280.0 24200.0 0.62 0.6975 0.9705 1603 SPBio_002011 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E14 compound treatment 221640.0 -6620.0 -0.18 228360.0 15300.0 0.39 0.1503 0.3519 3068961 SPBio_002012 CN/C(=N/C#N)/NCCSCC1N=CN=C1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E15 compound treatment 217120.0 -11100.0 -0.3 232800.0 19700.0 0.5 0.1449 0.2485 870 SPBio_002013 OC(=O)/C(=C/c1ccc(O)cc1)/C#N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E16 compound treatment 217640.0 -10600.0 -0.28 236160.0 23100.0 0.59 0.2151 0.3299 1432 SPBio_002014 CN(C)CCOC(C)(c1ccccc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E17 compound treatment 222560.0 -5700.0 -0.15 239640.0 26600.0 0.68 0.3704 0.5348 3055218 SPBio_002015 OCC(O)[C@H]1OC(=O)C(=C1O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E18 compound treatment 208200.0 -20100.0 -0.53 224680.0 11600.0 0.3 -0.1693 -0.2771 1000260 SPBio_002016 CC[C@H](CO)NCCN[C@H](CC)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E19 compound treatment 207120.0 -21100.0 -0.56 264280.0 51200.0 1.3 0.5223 0.3681 3198544 SPBio_002017 CC([C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E20 compound treatment 210640.0 -17600.0 -0.47 256160.0 43100.0 1.1 0.4427 0.3713 1108 SPBio_002018 Cc1cc(=O)n(c2ccccc2)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E21 compound treatment 213000.0 -15300.0 -0.41 229120.0 16100.0 0.41 0.0011 0.0018 3471107 SPBio_002019 NC(=O)c1cc[n+](CC2=C(N3C(SC2)C(NC(=O)C(c4ccccc4)S(=O)(=O)O)C3=O)C(=O)O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E22 compound treatment 209440.0 -18800.0 -0.5 240080.0 27000.0 0.69 0.131 0.154 1079457 SPBio_002020 Cc1c(O)c(=O)n(c2ccccc2)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E23 mock treatment 214760.0 -13500.0 -0.36 224000.0 10900.0 0.28 -0.0578 -0.1271 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 E24 mock treatment 228160.0 -96.9 0.0 217560.0 4500.0 0.11 0.079 0.691 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F01 mock treatment 215080.0 -13200.0 -0.35 237000.0 23900.0 0.61 0.1819 0.2589 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F02 mock treatment 211760.0 -16500.0 -0.44 228960.0 15900.0 0.4 -0.0252 -0.0422 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F03 compound treatment 89080.0 -139000.0 -3.71 59440.0 -154000.0 -3.91 -5.386 -0.9997 899 SPBio_002021 CN1CCc2cccc-3c2[C@H]1Cc4ccc(O)c(O)c43 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F04 compound treatment 218440.0 -9820.0 -0.26 222240.0 9180.0 0.23 -0.0201 -0.0573 1081 SPBio_002022 Cc1c(N)c(=O)n(c2ccccc2)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F05 compound treatment 229400.0 1140.0 0.03 320480.0 107000.0 2.73 1.9528 0.715 885 SPBio_002023 Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F06 compound treatment 218040.0 -10200.0 -0.27 250640.0 37600.0 0.96 0.483 0.4861 1274 SPBio_002024 C1CN2C[C@@H](N=C2S1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F07 compound treatment 205040.0 -23200.0 -0.62 226480.0 13400.0 0.34 -0.1965 -0.278 3326 SPBio_002025 CN1CCC(=C2c3ccccc3C=Cc4ccccc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F08 compound treatment 221760.0 -6500.0 -0.17 226720.0 13700.0 0.35 0.1231 0.3171 719 SPBio_002026 CN(CC#C)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F09 compound treatment 219240.0 -9020.0 -0.24 264840.0 51800.0 1.32 0.7609 0.5686 3177110 SPBio_002027 NC(=Nc1nc(CSCC/C(=N/S(=O)(=O)N)/N)cs1)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F10 compound treatment 271480.0 43200.0 1.15 236920.0 23900.0 0.61 1.2438 0.9551 1062 SPBio_002028 COc1ccccc1OCC(O)COC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F11 compound treatment 111640.0 -117000.0 -3.11 175920.0 -37100.0 -0.94 -2.8664 -0.8821 3189048 SPBio_002029 C[C@@]12CC[C@H]3[C@@H](CCC4=Cc5oncc5C[C@]34C)[C@@H]2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F12 compound treatment 223960.0 -4300.0 -0.11 243400.0 30300.0 0.77 0.4644 0.5956 3189063 SPBio_002030 C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)/c2csc(N)n2)C(=O)N1S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F13 compound treatment 246520.0 18300.0 0.49 240280.0 27200.0 0.69 0.8337 0.9852 3169 SPBio_002031 CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F14 compound treatment 226680.0 -1580.0 -0.04 226240.0 13200.0 0.34 0.2072 0.6136 1337 SPBio_002032 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F15 compound treatment 215360.0 -12900.0 -0.34 264680.0 51600.0 1.31 0.6849 0.5048 3189049 SPBio_002033 C[N+]1([O-])[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F16 compound treatment 205480.0 -22800.0 -0.61 232600.0 19500.0 0.5 -0.0782 -0.0996 724 SPBio_002034 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F17 compound treatment 232680.0 4420.0 0.12 237680.0 24600.0 0.63 0.526 0.8258 1386 SPBio_002035 CN1CC(c2ccccc2)c3cccc(N)c3C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F18 compound treatment 217480.0 -10800.0 -0.29 236960.0 23900.0 0.61 0.2265 0.3369 3045683 SPBio_002036 C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F19 compound treatment 241120.0 12900.0 0.34 275960.0 62900.0 1.6 1.3734 0.8397 907387 SPBio_002037 C[C@@]1(N[C@@H]2Cc3ccccc31)c4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F20 compound treatment 213960.0 -14300.0 -0.38 374800.0 162000.0 4.11 2.6384 0.6388 1428839 SPBio_002038 C(Nc1ncnc2[nH]cnc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F21 compound treatment 197160.0 -31100.0 -0.83 260080.0 47000.0 1.2 0.2591 0.1781 3069006 SPBio_002039 CC(=O)CC(c1ccc(cc1)[N+](=O)[O-])c2c(O)c3ccccc3oc2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F22 compound treatment 197840.0 -30400.0 -0.81 219160.0 6100.0 0.16 -0.4638 -0.5618 198 SPBio_002040 CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F23 mock treatment 227000.0 -1260.0 -0.03 237960.0 24900.0 0.63 0.4239 0.6687 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 F24 mock treatment 225600.0 -2660.0 -0.07 159160.0 -53900.0 -1.37 -1.0192 -0.7427 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G01 mock treatment 223640.0 -4620.0 -0.12 233760.0 20700.0 0.53 0.2851 0.5275 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G02 mock treatment 194200.0 -34100.0 -0.91 216280.0 3220.0 0.08 -0.5842 -0.6408 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G03 compound treatment 215320.0 -12900.0 -0.34 222520.0 9460.0 0.24 -0.0739 -0.1757 3058484 SPBio_002041 CC(CCC(=O)O)[C@H]1CCC2C3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G04 compound treatment 233320.0 5060.0 0.13 227320.0 14300.0 0.36 0.3518 0.9094 3188935 SPBio_002042 OC[C@@H](NC(=O)C(Cl)Cl)[C@@H](O)c1ccc(cc1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G05 compound treatment 20200.0 -208000.0 -5.55 20360.0 -193000.0 -4.9 -7.3872 -0.9981 2069269 SPBio_002043 COC(=O)CCC(C)C1CCC2C3CCC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G06 compound treatment 224040.0 -4220.0 -0.11 258120.0 45100.0 1.15 0.7306 0.6347 2702 SPBio_002044 COc1cc(C)nn1c2nc(C)cc(OC)n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G07 compound treatment 237120.0 8860.0 0.24 256120.0 43100.0 1.09 0.9412 0.8404 3059164 SPBio_002045 CC(C)CCCC(C)C1CCC2C3CC[C@H]4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G08 compound treatment 224360.0 -3900.0 -0.1 228600.0 15500.0 0.4 0.2059 0.504 697 SPBio_002046 Cn1c(=O)n(C)c2ncn(CC(O)CO)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G09 compound treatment 89160.0 -139000.0 -3.71 82320.0 -131000.0 -3.32 -4.9731 -0.9985 2060111 SPBio_002047 COc1cc(O)c(cc1O)C(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G10 compound treatment 86760.0 -141000.0 -3.77 84960.0 -128000.0 -3.26 -4.9709 -0.9973 1061 SPBio_002048 Nc1nc(N)c2nc(c(N)nc2n1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G11 compound treatment 277920.0 49700.0 1.32 237080.0 24000.0 0.61 1.3681 0.9382 2069324 SPBio_002049 COc1cc(/C=C/C(=O)O)cc(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G12 compound treatment 238200.0 9940.0 0.27 228240.0 15200.0 0.39 0.4603 0.9832 1186 SPBio_002050 Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G13 compound treatment 268400.0 40100.0 1.07 217120.0 4060.0 0.1 0.8298 0.7717 1029168 SPBio_002051 CC(=O)c1ccc[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G14 compound treatment 254640.0 26400.0 0.7 217160.0 4100.0 0.1 0.5711 0.8031 3188936 SPBio_002052 COC1CC(O[C@@H]2[C@H](C)[C@H](OC3OC(C)CC(C3OC(=O)C)N(C)C)[C@H](C)CC4(CO4)C(=O)[C@@H](C)C(OC(=O)C)[C@H](C)[C@H](C)OC(=O)[C@@H]2C)OC(C)C1OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G15 compound treatment 21760.0 -206000.0 -5.51 22680.0 -190000.0 -4.84 -7.3161 -0.9979 2060336 SPBio_002053 CCOc1cccc(c1)C(=O)c2ccc(O)c(O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G16 compound treatment 78360.0 -150000.0 -4.0 74640.0 -138000.0 -3.52 -5.3148 -0.998 1259 SPBio_002054 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G17 compound treatment 218160.0 -10100.0 -0.27 242000.0 28900.0 0.74 0.3299 0.4211 2060244 SPBio_002055 COC1=CC(=O)OC(CCc2ccc(OC)c(OC)c2)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G18 compound treatment 218120.0 -10100.0 -0.27 252320.0 39300.0 1.0 0.5147 0.4977 1270 SPBio_002056 C[N+](C)(C)CCCCCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G19 compound treatment 215480.0 -12800.0 -0.34 248480.0 35400.0 0.9 0.3959 0.4112 2060081 SPBio_002057 CC(=CCc1c(O)cc(C)oc1=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G20 compound treatment 201520.0 -26700.0 -0.71 270440.0 57400.0 1.46 0.5275 0.3249 1518 SPBio_002058 OC(=O)c1cc(ccc1O)c2ccc(F)cc2F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G21 compound treatment 219440.0 -8820.0 -0.24 250240.0 37200.0 0.95 0.5022 0.5156 1091 SPBio_002059 CCc1cn(C2OCC(O)C2CO)c(=O)nc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G22 compound treatment 33040.0 -195000.0 -5.2 39560.0 -174000.0 -4.41 -6.7999 -0.9966 1313 SPBio_002060 Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G23 mock treatment 214760.0 -13500.0 -0.36 205840.0 -7220.0 -0.18 -0.3843 -0.9513 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 G24 mock treatment 247080.0 18800.0 0.5 147680.0 -65400.0 -1.66 -0.8207 -0.4726 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H01 mock treatment 222960.0 -5300.0 -0.14 224840.0 11800.0 0.3 0.1119 0.3379 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H02 mock treatment 220960.0 -7300.0 -0.19 208200.0 -4860.0 -0.12 -0.225 -0.9761 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H03 compound treatment 215520.0 -12700.0 -0.34 213960.0 897.0 0.02 -0.224 -0.6581 929 SPBio_002061 Oc1ccc2C[C@H]3N(CC=C)CC[C@]4([C@H]5Oc1c24)[C@@]3(O)CCC5=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H04 compound treatment 233680.0 5420.0 0.14 219800.0 6740.0 0.17 0.2234 0.9964 1535 SPBio_002062 COc1ccc(OC)c(c1)C(O)CNC(=O)CN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H05 compound treatment 251040.0 22800.0 0.61 227200.0 14100.0 0.36 0.6837 0.9686 918 SPBio_002063 CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H06 compound treatment 222680.0 -5580.0 -0.15 247920.0 34900.0 0.89 0.5216 0.5804 370 SPBio_002064 O=C1N(C2CCC(=O)NC2=O)C(=O)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H07 compound treatment 230520.0 2260.0 0.06 234720.0 21700.0 0.55 0.432 0.7799 757 SPBio_002065 OC(=O)c1cn(C2CC2)c3cc(N4CCNCC4)c(F)cc3c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H08 compound treatment 238440.0 10200.0 0.27 248640.0 35600.0 0.9 0.8316 0.8805 1266 SPBio_002066 CCn1cc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H09 compound treatment 221320.0 -6940.0 -0.18 251120.0 38100.0 0.97 0.5535 0.5618 1092 SPBio_002067 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H10 compound treatment 229560.0 1300.0 0.03 223360.0 10300.0 0.26 0.2097 0.794 1298 SPBio_002068 CS(=O)(=O)Nc1ccc(cc1Oc2ccccc2)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H11 compound treatment 217120.0 -11100.0 -0.3 248640.0 35600.0 0.9 0.4297 0.4513 1261 SPBio_002069 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H12 compound treatment 269520.0 41300.0 1.1 233680.0 20600.0 0.52 1.1486 0.9425 1482 SPBio_002070 CN1CCc2cc3OCOc3cc2C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H13 compound treatment 259040.0 30800.0 0.82 244360.0 31300.0 0.8 1.1431 0.9999 3189051 SPBio_002071 Oc1ccc2C[C@H]3N(CC4CC4)CC[C@]5([C@H]6Oc1c25)[C@@]3(O)CCC6=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H14 compound treatment 273680.0 45400.0 1.21 233280.0 20200.0 0.51 1.2199 0.9272 1331 SPBio_002072 CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H15 compound treatment 280840.0 52600.0 1.4 231720.0 18700.0 0.47 1.3268 0.8964 1207 SPBio_002073 CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H16 compound treatment 269160.0 40900.0 1.09 235840.0 22800.0 0.58 1.1807 0.9562 3189174 SPBio_002074 C[C@H](N)[C@H](O)c1cccc(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H17 compound treatment 289480.0 61200.0 1.63 272000.0 58900.0 1.5 2.2139 0.9991 1027 SPBio_002075 O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CCC6)c54 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H18 compound treatment 268560.0 40300.0 1.07 247760.0 34700.0 0.88 1.3837 0.9952 1523 SPBio_002076 CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H19 compound treatment 224560.0 -3700.0 -0.1 225560.0 12500.0 0.32 0.155 0.4659 2241 SPBio_002077 COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H20 compound treatment 204960.0 -23300.0 -0.62 209760.0 -3300.0 -0.08 -0.4986 -0.7955 1436 SPBio_002078 CCCNC(C)C(=O)Nc1ccccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H21 compound treatment 219200.0 -9060.0 -0.24 241080.0 28000.0 0.71 0.333 0.4427 1002008 SPBio_002079 C[C@@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]2C[C@@H](O)[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H22 compound treatment 25680.0 -203000.0 -5.4 23720.0 -189000.0 -4.81 -7.2235 -0.9984 383 SPBio_002080 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccccc5cc4Cn3c2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H23 mock treatment 235960.0 7700.0 0.21 220400.0 7340.0 0.19 0.2771 0.9988 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 H24 mock treatment 235040.0 6780.0 0.18 148640.0 -64400.0 -1.64 -1.0304 -0.6252 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I01 mock treatment 222400.0 -5860.0 -0.16 207560.0 -5500.0 -0.14 -0.2094 -0.9985 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I02 mock treatment 207840.0 -20400.0 -0.54 212080.0 -983.0 -0.02 -0.4026 -0.7388 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I03 compound treatment 208720.0 -19500.0 -0.52 221600.0 8540.0 0.22 -0.2148 -0.3807 3080395 SPBio_002081 CC(C)CCCC(C)C1CCC2C3CC[C@H]4CCCC[C@]4(C)C3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I04 compound treatment 205760.0 -22500.0 -0.6 217200.0 4140.0 0.11 -0.3498 -0.5743 779 SPBio_002082 CCN(CC)CCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I05 compound treatment 212040.0 -16200.0 -0.43 241280.0 28200.0 0.72 0.2016 0.2406 3526 SPBio_002083 Oc1ccc2ccc(=O)oc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I06 compound treatment 228160.0 -96.9 0.0 229320.0 16300.0 0.41 0.2905 0.7027 2847 SPBio_002084 CC(C)c1cc(OC(=O)C)c(C)cc1OCCN(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I07 compound treatment 207680.0 -20600.0 -0.55 197800.0 -15300.0 -0.39 -0.6624 -0.9856 3198545 SPBio_002085 Oc1ccc(/C=C/C=O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I08 compound treatment 237680.0 9420.0 0.25 234800.0 21700.0 0.55 0.5685 0.9363 3068964 SPBio_002086 NCCc1cc[nH]n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I09 compound treatment 240320.0 12100.0 0.32 225520.0 12500.0 0.32 0.4514 1.0 1008535 SPBio_002087 COc1cccc(C=O)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I10 compound treatment 252200.0 23900.0 0.64 224440.0 11400.0 0.29 0.656 0.9359 1268 SPBio_002088 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3cc(C)on3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I11 compound treatment 234400.0 6140.0 0.16 225840.0 12800.0 0.32 0.3455 0.9497 762 SPBio_002089 COc1cccc(OC)c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I12 compound treatment 246800.0 18500.0 0.49 217400.0 4340.0 0.11 0.4276 0.8441 1000165 SPBio_002090 COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I13 compound treatment 245840.0 17600.0 0.47 223840.0 10800.0 0.27 0.5253 0.9673 3055245 SPBio_002091 CCC[C@@H]1CCCCN1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I14 compound treatment 238680.0 10400.0 0.28 233640.0 20600.0 0.52 0.5665 0.9562 1083 SPBio_002092 C(C1=NCCN1)c2cccc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I15 compound treatment 19600.0 -209000.0 -5.56 28120.0 -185000.0 -4.7 -7.259 -0.9965 1496 SPBio_002093 CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I16 compound treatment 232160.0 3900.0 0.1 237080.0 24000.0 0.61 0.5054 0.8158 1821 SPBio_002094 Clc1ccccc1CN2CCc3sccc3C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I17 compound treatment 237920.0 9660.0 0.26 255320.0 42300.0 1.07 0.9419 0.8525 1280 SPBio_002095 NCCNC(=O)c1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I18 compound treatment 243400.0 15100.0 0.4 224560.0 11500.0 0.29 0.4922 0.9874 819 SPBio_002096 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I19 compound treatment 219520.0 -8740.0 -0.23 237480.0 24400.0 0.62 0.2743 0.4136 1440 SPBio_002097 COc1ccc2cc(CCC(=O)C)ccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I20 compound treatment 213120.0 -15100.0 -0.4 220920.0 7860.0 0.2 -0.1441 -0.32 3188937 SPBio_002098 CCC(C)(CN(C)C)OC(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I21 compound treatment 315720.0 87500.0 2.33 209200.0 -3860.0 -0.1 1.5795 0.6767 1069 SPBio_002099 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I22 compound treatment 224680.0 -3580.0 -0.1 211280.0 -1780.0 -0.05 -0.0995 -0.9422 362 SPBio_002100 CCN(CC)CC(=O)Nc1c(C)cccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I23 mock treatment 216720.0 -11500.0 -0.31 220440.0 7380.0 0.19 -0.0849 -0.2356 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 I24 mock treatment 241760.0 13500.0 0.36 146160.0 -66900.0 -1.7 -0.9483 -0.5454 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J01 mock treatment 232440.0 4180.0 0.11 208680.0 -4380.0 -0.11 1.0E-4 4.0E-4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J02 mock treatment 210080.0 -18200.0 -0.48 227800.0 14700.0 0.37 -0.0777 -0.1269 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J03 compound treatment 220880.0 -7380.0 -0.2 202040.0 -11000.0 -0.28 -0.3373 -0.985 1000273 SPBio_002101 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J04 compound treatment 219160.0 -9100.0 -0.24 224040.0 11000.0 0.28 0.0259 0.0699 1068 SPBio_002102 CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(CN(C)C)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J05 compound treatment 219720.0 -8540.0 -0.23 227600.0 14500.0 0.37 0.1004 0.2313 3069040 SPBio_002103 CNCC(O)c1ccc(O)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J06 compound treatment 158360.0 -69900.0 -1.86 165520.0 -47500.0 -1.21 -2.1726 -0.978 3069077 SPBio_002104 OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J07 compound treatment 237320.0 9060.0 0.24 226800.0 13700.0 0.35 0.4179 0.9838 3189053 SPBio_002105 CC(C)CCC(=O)O.C[C@]12CCC[C@H]2[C@H]3[C@H](CC1=O)[C@@]4(C)CCC(=O)C[C@H]4CC3=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J08 compound treatment 184800.0 -43500.0 -1.16 200840.0 -12200.0 -0.31 -1.0391 -0.8662 41 SPBio_002106 OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J09 compound treatment 251240.0 23000.0 0.61 237280.0 24200.0 0.62 0.8687 1.0 1610 SPBio_002107 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J10 compound treatment 249280.0 21000.0 0.56 250960.0 37900.0 0.96 1.0777 0.9668 752 SPBio_002108 CC1CCc2cc(F)cc3c(=O)c(cn1c23)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J11 compound treatment 167280.0 -61000.0 -1.63 178240.0 -34800.0 -0.89 -1.7757 -0.9592 1465 SPBio_002109 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J12 compound treatment 207320.0 -20900.0 -0.56 202480.0 -10600.0 -0.27 -0.585 -0.944 1258696 SPBio_002110 Cc1c(Cl)cccc1Nc2ccccc2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J13 compound treatment 190400.0 -37900.0 -1.01 250800.0 37700.0 0.96 -0.0352 -0.0253 1387 SPBio_002111 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J14 compound treatment 163880.0 -64400.0 -1.72 153520.0 -59500.0 -1.51 -2.2843 -0.998 1123 SPBio_002112 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J15 compound treatment 19240.0 -209000.0 -5.57 16920.0 -196000.0 -4.99 -7.4672 -0.9985 3487389 SPBio_002113 Clc1ccc(C(Cn2ccnc2)OCc3c(Cl)cccc3Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J16 compound treatment 240240.0 12000.0 0.32 233640.0 20600.0 0.52 0.5959 0.972 3189175 SPBio_002114 COC1=CC(=O)O[C@H](C1)/C=C/c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J17 compound treatment 239800.0 11500.0 0.31 215280.0 2220.0 0.06 0.2575 0.8229 3189054 SPBio_002115 CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)[C@H]13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J18 compound treatment 241160.0 12900.0 0.34 223360.0 10300.0 0.26 0.4284 0.9909 1201 SPBio_002116 COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J19 compound treatment 240240.0 12000.0 0.32 245000.0 31900.0 0.81 0.8001 0.9169 786 SPBio_002117 CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J20 compound treatment 231960.0 3700.0 0.1 232520.0 19500.0 0.49 0.4196 0.8318 734 SPBio_002118 CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J21 compound treatment 241960.0 13700.0 0.37 224080.0 11000.0 0.28 0.4564 0.9914 1000246 SPBio_002119 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J22 compound treatment 75000.0 -153000.0 -4.09 139440.0 -73600.0 -1.87 -4.2131 -0.9374 1281686 SPBio_002120 COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J23 mock treatment 238240.0 9980.0 0.27 231200.0 18100.0 0.46 0.5143 0.9659 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 J24 mock treatment 224200.0 -4060.0 -0.11 194280.0 -18800.0 -0.48 -0.4142 -0.8458 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K01 mock treatment 219920.0 -8340.0 -0.22 179520.0 -33500.0 -0.85 -0.7603 -0.8626 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K02 mock treatment 224520.0 -3740.0 -0.1 212360.0 -703.0 -0.02 -0.0831 -0.8208 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K03 compound treatment 195320.0 -32900.0 -0.88 208920.0 -4140.0 -0.11 -0.6955 -0.7863 2060334 SPBio_002121 C[C@H]1[C@@H](O)C[C@H]2[C@@H]1[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)OC=C2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K04 compound treatment 214080.0 -14200.0 -0.38 226080.0 13000.0 0.33 -0.0332 -0.0662 1010605 SPBio_002122 COP(=O)(OC)C(O)C(Cl)(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K05 compound treatment 204440.0 -23800.0 -0.64 229360.0 16300.0 0.41 -0.156 -0.2058 2060497 SPBio_002123 CC(C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C#N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K06 compound treatment 206480.0 -21800.0 -0.58 254040.0 41000.0 1.04 0.3262 0.2735 1019 SPBio_002124 NC(=O)N1c2ccccc2C=Cc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K07 compound treatment 220960.0 -7300.0 -0.19 222680.0 9620.0 0.24 0.0353 0.1131 1765 SPBio_002125 CC1(C)NC(=O)N(C1=O)c2ccc([N+](=O)[O-])c(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K08 compound treatment 219320.0 -8940.0 -0.24 210520.0 -2540.0 -0.06 -0.2142 -0.8676 1401 SPBio_002126 CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K09 compound treatment 227200.0 -1060.0 -0.03 249800.0 36700.0 0.93 0.6406 0.6855 3057756 SPBio_002127 C1CCN2C[C@H]3C[C@@H](CN4CCCC[C@H]34)[C@@H]2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K10 compound treatment 259520.0 31300.0 0.83 260720.0 47700.0 1.21 1.4463 0.9833 939 SPBio_002128 Cc1cccc(Nc2ccccc2C(=O)O)c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K11 compound treatment 297160.0 68900.0 1.84 222720.0 9660.0 0.25 1.4727 0.7946 3198546 SPBio_002129 CC(=CCC/C(=C/COC(=O)\C=C\c1ccccc1)/C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K12 compound treatment 288800.0 60500.0 1.61 239960.0 26900.0 0.68 1.625 0.9269 3186 SPBio_002130 CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K13 compound treatment 275000.0 46700.0 1.25 219520.0 6460.0 0.16 0.9974 0.7934 3198547 SPBio_002131 CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)c4ccccc4C(=O)O)c5nc6ccccc6n5C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K14 compound treatment 232680.0 4420.0 0.12 257480.0 44400.0 1.13 0.882 0.7767 920 SPBio_002132 CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K15 compound treatment 114800.0 -113000.0 -3.03 137440.0 -75600.0 -1.92 -3.4987 -0.9761 2060467 SPBio_002133 COc1ccc2C(=O)/C(=C\c3ccc(OC)c(OC)c3)/COc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K16 compound treatment 166320.0 -61900.0 -1.65 148200.0 -64900.0 -1.65 -2.3339 -1.0 3127 SPBio_002134 CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K17 compound treatment 291600.0 63300.0 1.69 212240.0 -823.0 -0.02 1.1794 0.6983 1024489 SPBio_002135 Cc1cc(O)cc(=O)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K18 compound treatment 234080.0 5820.0 0.16 198240.0 -14800.0 -0.38 -0.1567 -0.3845 1318 SPBio_002136 CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K19 compound treatment 167120.0 -61100.0 -1.63 147200.0 -65900.0 -1.67 -2.3368 -0.9999 3045136 SPBio_002137 CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)C(CCC3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K20 compound treatment 252840.0 24600.0 0.66 223640.0 10600.0 0.27 0.6536 0.9226 884 SPBio_002138 CN(C)CCC(c1ccccc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K21 compound treatment 229240.0 983.0 0.03 213560.0 497.0 0.01 0.0275 0.9441 794 SPBio_002139 Nc1cc(c[nH]c1=O)c2ccncc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K22 compound treatment 262040.0 33800.0 0.9 211480.0 -1580.0 -0.04 0.6085 0.6748 965 SPBio_002140 C(C1=NCCN1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K23 mock treatment 218880.0 -9380.0 -0.25 205080.0 -7980.0 -0.2 -0.3203 -0.9947 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 K24 mock treatment 232800.0 4540.0 0.12 174120.0 -38900.0 -0.99 -0.6145 -0.616 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L01 mock treatment 237480.0 9220.0 0.25 181840.0 -31200.0 -0.79 -0.3875 -0.4662 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L02 mock treatment 241080.0 12800.0 0.34 199680.0 -13400.0 -0.34 0.0011 0.0024 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L03 compound treatment 261560.0 33300.0 0.89 217440.0 4380.0 0.11 0.7066 0.7896 72 SPBio_002141 Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L04 compound treatment 249200.0 20900.0 0.56 218880.0 5820.0 0.15 0.4994 0.8646 347 SPBio_002142 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L05 compound treatment 235400.0 7140.0 0.19 232480.0 19400.0 0.49 0.4838 0.9142 4362 SPBio_002143 CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L06 compound treatment 206160.0 -22100.0 -0.59 240480.0 27400.0 0.7 0.0763 0.0836 3069079 SPBio_002144 CN1CCCN=C1/C=C/c2cccs2.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L07 compound treatment 204120.0 -24100.0 -0.64 210840.0 -2220.0 -0.06 -0.495 -0.7663 3487390 SPBio_002145 OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L08 compound treatment 286840.0 58600.0 1.56 231640.0 18600.0 0.47 1.4385 0.8815 1144 SPBio_002146 O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L09 compound treatment 238960.0 10700.0 0.29 222880.0 9820.0 0.25 0.3783 0.9978 355 SPBio_002147 COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L10 compound treatment 246200.0 17900.0 0.48 217280.0 4220.0 0.11 0.4141 0.8446 796 SPBio_002148 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L11 compound treatment 117800.0 -110000.0 -2.95 99960.0 -113000.0 -2.88 -4.116 -0.9999 464 SPBio_002149 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L12 compound treatment 232600.0 4340.0 0.12 259080.0 46000.0 1.17 0.9092 0.7733 1346 SPBio_002150 CCN(CC)CCNC(=O)COc1ccc(OC)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L13 compound treatment 75080.0 -153000.0 -4.08 102080.0 -111000.0 -2.82 -4.8833 -0.9837 709 SPBio_002151 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L14 compound treatment 262160.0 33900.0 0.9 222200.0 9140.0 0.23 0.8035 0.8609 1339 SPBio_002152 CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L15 compound treatment 261400.0 33100.0 0.88 227520.0 14500.0 0.37 0.8848 0.9245 3189055 SPBio_002153 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L16 compound treatment 149160.0 -79100.0 -2.11 116160.0 -96900.0 -2.46 -3.2335 -0.997 1350 SPBio_002154 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L17 compound treatment 258200.0 29900.0 0.8 287280.0 74200.0 1.89 1.8989 0.9267 1590 SPBio_002155 CC(C)(C)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L18 compound treatment 247640.0 19400.0 0.52 212320.0 -743.0 -0.02 0.3521 0.6808 699 SPBio_002156 OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L19 compound treatment 271920.0 43700.0 1.16 225480.0 12400.0 0.32 1.0464 0.8675 3060388 SPBio_002157 CO/N=C(\C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C)/c3csc(N)n3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L20 compound treatment 243760.0 15500.0 0.41 217280.0 4220.0 0.11 0.3681 0.862 1209 SPBio_002158 CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L21 compound treatment 259120.0 30900.0 0.82 224280.0 11200.0 0.29 0.7835 0.8997 1418 SPBio_002159 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L22 compound treatment 312240.0 84000.0 2.24 227200.0 14100.0 0.36 1.8375 0.8102 3069113 SPBio_002160 CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L23 mock treatment 250480.0 22200.0 0.59 236200.0 23100.0 0.59 0.835 1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 L24 mock treatment 256560.0 28300.0 0.75 200280.0 -12800.0 -0.33 0.3038 0.3697 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M01 mock treatment 254680.0 26400.0 0.7 186400.0 -26700.0 -0.68 0.0188 0.0192 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M02 mock treatment 225760.0 -2500.0 -0.07 196360.0 -16700.0 -0.42 -0.3474 -0.8081 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M03 compound treatment 209720.0 -18500.0 -0.49 197600.0 -15500.0 -0.39 -0.6275 -0.9936 1110410 SPBio_002161 COc1ccc(C(=O)C)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M04 compound treatment 217560.0 -10700.0 -0.29 219160.0 6100.0 0.16 -0.092 -0.2836 3188938 SPBio_002162 CN1CCCN=C1/C=C/c2sccc2C.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M05 compound treatment 246920.0 18700.0 0.5 204800.0 -8260.0 -0.21 0.2033 0.3764 1582 SPBio_002163 O=C1CCO1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M06 compound treatment 236000.0 7740.0 0.21 211280.0 -1780.0 -0.05 0.1139 0.539 3068999 SPBio_002164 CN1[C@H]2CC[C@@H]1CC(C2)OC(=O)C(O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M07 compound treatment 246840.0 18600.0 0.5 214960.0 1900.0 0.05 0.3845 0.7723 104 SPBio_002165 C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M08 compound treatment 108320.0 -120000.0 -3.2 50120.0 -163000.0 -4.14 -5.1908 -0.9918 110 SPBio_002166 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M09 compound treatment 275400.0 47100.0 1.26 230840.0 17800.0 0.45 1.2084 0.9047 1000323 SPBio_002167 N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M10 compound treatment 232560.0 4300.0 0.11 219720.0 6660.0 0.17 0.2008 0.9821 436 SPBio_002168 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M11 compound treatment 236920.0 8660.0 0.23 216080.0 3020.0 0.08 0.2176 0.8939 1328 SPBio_002169 OC(CCN1CCCCC1)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M12 compound treatment 251040.0 22800.0 0.61 232680.0 19600.0 0.5 0.7822 0.9952 1002 SPBio_002170 CN(C)CCOC(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M13 compound treatment 231560.0 3300.0 0.09 223360.0 10300.0 0.26 0.2474 0.8956 1510 SPBio_002171 CN(C)CCN(Cc1cccs1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M14 compound treatment 239000.0 10700.0 0.29 220400.0 7340.0 0.19 0.3345 0.9784 728 SPBio_002172 Cc1cc(nnc1NCCN2CCOCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M15 compound treatment 215240.0 -13000.0 -0.35 179360.0 -33700.0 -0.86 -0.8514 -0.9208 1318 SPBio_002173 CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M16 compound treatment 21200.0 -207000.0 -5.52 16560.0 -197000.0 -5.0 -7.4367 -0.9988 814 SPBio_002174 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M17 compound treatment 224480.0 -3780.0 -0.1 211560.0 -1500.0 -0.04 -0.0982 -0.912 3174608 SPBio_002175 COC1C(O)C(O)C(O)[C@@H](O)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M18 compound treatment 210600.0 -17700.0 -0.47 213040.0 -22.9 0.0 -0.3333 -0.708 3471598 SPBio_002176 CC(COc1ccccc1)NC(C)C(O)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M19 compound treatment 184040.0 -44200.0 -1.18 170160.0 -42900.0 -1.09 -1.605 -0.9992 1035250 SPBio_002177 CC(=O)c1c(O)cc(O)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M20 compound treatment 220320.0 -7940.0 -0.21 209560.0 -3500.0 -0.09 -0.2126 -0.926 1223 SPBio_002178 CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M21 compound treatment 221240.0 -7020.0 -0.19 221360.0 8300.0 0.21 0.0169 0.0599 3080396 SPBio_002179 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M22 compound treatment 200640.0 -27600.0 -0.74 185640.0 -27400.0 -0.7 -1.0137 -0.9996 971 SPBio_002180 CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M23 mock treatment 207560.0 -20700.0 -0.55 194680.0 -18400.0 -0.47 -0.7207 -0.9966 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 M24 mock treatment 232320.0 4060.0 0.11 185000.0 -28100.0 -0.71 -0.4279 -0.593 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N01 mock treatment 250480.0 22200.0 0.59 190440.0 -22600.0 -0.58 0.0122 0.0148 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N02 mock treatment 243200.0 14900.0 0.4 222320.0 9260.0 0.24 0.4482 0.9685 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N03 compound treatment 210440.0 -17800.0 -0.48 190560.0 -22500.0 -0.57 -0.7405 -0.9957 1000056 SPBio_002181 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N04 compound treatment 252320.0 24100.0 0.64 218480.0 5420.0 0.14 0.5511 0.8398 747 SPBio_002182 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N05 compound treatment 221040.0 -7220.0 -0.19 180080.0 -33000.0 -0.84 -0.7291 -0.8473 1301 SPBio_002183 OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N06 compound treatment 107360.0 -121000.0 -3.22 95360.0 -118000.0 -2.99 -4.3955 -0.9993 3189176 SPBio_002184 CCCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)C(NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N07 compound treatment 37120.0 -191000.0 -5.1 16640.0 -196000.0 -4.99 -7.1351 -0.9999 1360 SPBio_002185 Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N08 compound treatment 222000.0 -6260.0 -0.17 197480.0 -15600.0 -0.4 -0.3981 -0.9261 816 SPBio_002186 Cc1cc(cc(C)c1CC2=NCCN2)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N09 compound treatment 223800.0 -4460.0 -0.12 186000.0 -27100.0 -0.69 -0.5706 -0.8171 80 SPBio_002187 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N10 compound treatment 241040.0 12800.0 0.34 226440.0 13400.0 0.34 0.4815 1.0 1181 SPBio_002188 Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N11 compound treatment 246840.0 18600.0 0.5 221000.0 7940.0 0.2 0.4931 0.9216 901 SPBio_002189 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N12 compound treatment 237120.0 8860.0 0.24 212320.0 -743.0 -0.02 0.1537 0.6485 1162 SPBio_002190 Cc1c(NC(=O)c2cccnc2)c(=O)n(c3ccccc3)n1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N13 compound treatment 23000.0 -205000.0 -5.47 20320.0 -193000.0 -4.9 -7.3351 -0.9985 368 SPBio_002191 CC/C(=C(\c1ccccc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N14 compound treatment 235080.0 6820.0 0.18 206880.0 -6180.0 -0.16 0.0175 0.0727 3069117 SPBio_002192 COC1CC(=O)C[C@@H](C)[C@@]21Oc3c(C2=O)c(OC)cc(OC)c3Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N15 compound treatment 231400.0 3140.0 0.08 223200.0 10100.0 0.26 0.2415 0.8911 783 SPBio_002193 CO[C@@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]2Cc4cn(C)c5cccc1c45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N16 compound treatment 238120.0 9860.0 0.26 148080.0 -65000.0 -1.65 -0.9824 -0.5872 386963 SPBio_002194 Clc1ccc(Cn2c(CN3CCCC3)nc4ccccc24)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N17 compound treatment 239160.0 10900.0 0.29 196800.0 -16300.0 -0.41 -0.0868 -0.1718 2784 SPBio_002195 C[C@@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@]1(O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N18 compound treatment 240320.0 12100.0 0.32 190240.0 -22800.0 -0.58 -0.1829 -0.2757 1075 SPBio_002196 CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N19 compound treatment 212880.0 -15400.0 -0.41 194800.0 -18300.0 -0.46 -0.6183 -0.9981 3189056 SPBio_002197 CN(C)S(=O)(=O)c1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N20 compound treatment 219800.0 -8460.0 -0.23 218520.0 5460.0 0.14 -0.0613 -0.2316 1016 SPBio_002198 CN1CCOC(c2ccccc2)c3ccccc3C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N21 compound treatment 216040.0 -12200.0 -0.33 205600.0 -7460.0 -0.19 -0.3645 -0.9669 3189057 SPBio_002199 CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)C(=O)N[C@]5(C)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C5=O.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N22 compound treatment 211480.0 -16800.0 -0.45 205520.0 -7540.0 -0.19 -0.4519 -0.9285 3046406 SPBio_002200 Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N23 mock treatment 216120.0 -12100.0 -0.32 216520.0 3460.0 0.09 -0.1667 -0.497 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 N24 mock treatment 225120.0 -3140.0 -0.08 193880.0 -19200.0 -0.49 -0.404 -0.8164 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O01 mock treatment 227680.0 -577.0 -0.02 205240.0 -7820.0 -0.2 -0.1515 -0.7595 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O02 mock treatment 259120.0 30900.0 0.82 210680.0 -2380.0 -0.06 0.539 0.6533 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O03 compound treatment 229040.0 783.0 0.02 162960.0 -50100.0 -1.27 -0.886 -0.6954 1572 SPBio_002201 CCCC(C)C1(CC)C(=O)NC(=NC1=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O04 compound treatment 225400.0 -2860.0 -0.08 231080.0 18000.0 0.46 0.2701 0.5816 1125 SPBio_002202 CCOC(=O)NNc1nncc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O05 compound treatment 232320.0 4060.0 0.11 221720.0 8660.0 0.22 0.2323 0.9467 2060373 SPBio_002203 COc1c(O)cc2c(cc(=O)oc2c1OC)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O06 compound treatment 224440.0 -3820.0 -0.1 189720.0 -23300.0 -0.59 -0.4916 -0.8164 1174 SPBio_002204 CN(C)CCCN1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O07 compound treatment 244720.0 16500.0 0.44 187680.0 -25400.0 -0.65 -0.146 -0.187 1019888 SPBio_002205 NCC(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O08 compound treatment 246840.0 18600.0 0.5 195640.0 -17400.0 -0.44 0.0371 0.0558 3188939 SPBio_002206 CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O09 compound treatment 269760.0 41500.0 1.11 226400.0 13300.0 0.34 1.0223 0.8833 2069272 SPBio_002207 CC1C[C@H]2CC(=O)[C@H]3CCCN4CCC[C@H]2[C@]34C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O10 compound treatment 237560.0 9300.0 0.25 182720.0 -30300.0 -0.77 -0.3701 -0.4567 1365 SPBio_002208 CN(C)CCC=C1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O11 compound treatment 270360.0 42100.0 1.12 255960.0 42900.0 1.09 1.565 0.9999 2060313 SPBio_002209 C/C/1=C/CC(C)(C)\C=C\C\C(=C\CC1)\C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O12 compound treatment 259360.0 31100.0 0.83 244400.0 31300.0 0.8 1.1498 0.9998 872 SPBio_002210 CCN(CC)CCOC(=O)C(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O13 compound treatment 279960.0 51700.0 1.38 259120.0 46100.0 1.17 1.8028 0.9967 2060368 SPBio_002211 CNC(Cc1c[nH]c2ccccc12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O14 compound treatment 220120.0 -8140.0 -0.22 218160.0 5100.0 0.13 -0.0618 -0.2444 969 SPBio_002212 CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O15 compound treatment 280080.0 51800.0 1.38 218280.0 5220.0 0.13 1.0708 0.7714 1635952 SPBio_002213 Cn1nnnc1SCC2=C(N3C(SC2)C(NC(=O)C(O)c4ccccc4)C3=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O16 compound treatment 302920.0 74700.0 1.99 193640.0 -19400.0 -0.49 1.0584 0.516 2080073 SPBio_002214 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O17 compound treatment 255720.0 27500.0 0.73 189160.0 -23900.0 -0.61 0.088 0.0925 1573 SPBio_002215 CCCC(C)C1(CC)C(=O)NC(=NC1=O)S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O18 compound treatment 131720.0 -96500.0 -2.57 64680.0 -148000.0 -3.77 -4.4879 -0.9826 731 SPBio_002216 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O19 compound treatment 279160.0 50900.0 1.36 223960.0 10900.0 0.28 1.1556 0.8343 89599 SPBio_002217 OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O20 compound treatment 260960.0 32700.0 0.87 210080.0 -2980.0 -0.08 0.5629 0.6432 1001312 SPBio_002218 C[N+]1(C)CCC(=C(c2ccccc2)c3ccccc3)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O21 compound treatment 273120.0 44900.0 1.2 201320.0 -11700.0 -0.3 0.6347 0.5148 3198548 SPBio_002219 OC(=O)CCC/C=C\C[C@@H]1CO[C@@H](O[C@@H]1c2ccccc2O)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O22 compound treatment 263160.0 34900.0 0.93 247160.0 34100.0 0.87 1.2711 0.9994 1053 SPBio_002220 COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O23 mock treatment 268400.0 40100.0 1.07 235560.0 22500.0 0.57 1.1613 0.9569 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 O24 mock treatment 256840.0 28600.0 0.76 241440.0 28400.0 0.72 1.0491 0.9996 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P01 mock treatment 218520.0 -9740.0 -0.26 211000.0 -2060.0 -0.05 -0.2207 -0.8331 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P02 mock treatment 257280.0 29000.0 0.77 208680.0 -4380.0 -0.11 0.4684 0.5991 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P03 compound treatment 238120.0 9860.0 0.26 201800.0 -11300.0 -0.29 -0.0165 -0.0426 3069044 SPBio_002221 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P04 compound treatment 237120.0 8860.0 0.24 192280.0 -20800.0 -0.53 -0.2066 -0.3568 805 SPBio_002222 CCc1cccc2c3CCOC(CC)(CC(=O)O)c3[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P05 compound treatment 333640.0 105000.0 2.81 181760.0 -31300.0 -0.8 1.424 0.4876 3189058 SPBio_002223 COC1CC(O[C@H]2[C@H](C)[C@@H](OC3OC(C)CC(C3O)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)OC(C)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P06 compound treatment 239080.0 10800.0 0.29 210400.0 -2660.0 -0.07 0.1562 0.5269 3069144 SPBio_002224 C[N+]1([O-])[C@H]2C[C@@H](C[C@@H]1[C@H]3O[C@H]32)OC(=O)[C@H](CO)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P07 compound treatment 280200.0 51900.0 1.38 196960.0 -16100.0 -0.41 0.6898 0.4776 3189059 SPBio_002225 CCC(=O)OC1C(C)OC(CC1(C)O)OC2C(C)OC(O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)C(O)C2N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P08 compound treatment 273560.0 45300.0 1.21 178080.0 -35000.0 -0.89 0.2251 0.1501 1000200 SPBio_002226 CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)[C@@H](CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P09 compound treatment 299080.0 70800.0 1.89 194600.0 -18500.0 -0.47 1.0033 0.5156 3069045 SPBio_002227 CO[C@H]1[C@@H](CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(C2O)N(C)C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P10 compound treatment 268920.0 40700.0 1.08 186320.0 -26700.0 -0.68 0.2858 0.2233 3487401 SPBio_002228 NC(=O)OCC(O)COc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P11 compound treatment 150640.0 -77600.0 -2.07 130360.0 -82700.0 -2.1 -2.9503 -1.0 3189060 SPBio_002229 CC(=O)O[C@@H]1C2=C(C)[C@@H](C[C@](O)([C@H](OC(=O)c3ccccc3)[C@H]4[C@]5(CO[C@H]5C[C@@H](O)[C@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@@H](O)[C@H](NC(=O)c6ccccc6)c7ccccc7 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P12 compound treatment 225440.0 -2820.0 -0.08 169960.0 -43100.0 -1.1 -0.8281 -0.7538 3189177 SPBio_002230 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N=C)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P13 compound treatment 15320.0 -213000.0 -5.68 12840.0 -200000.0 -5.09 -7.6144 -0.9985 3189061 SPBio_002231 CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C/C=C(\C)/C(O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P14 compound treatment 288960.0 60700.0 1.62 225640.0 12600.0 0.32 1.3706 0.8308 2997 SPBio_002232 COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P15 compound treatment 252960.0 24700.0 0.66 200160.0 -12900.0 -0.33 0.2338 0.3177 1257 SPBio_002233 CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P16 compound treatment 269760.0 41500.0 1.11 197960.0 -15100.0 -0.38 0.5109 0.4362 1323 SPBio_002234 CC1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P17 compound treatment 288120.0 59900.0 1.6 198840.0 -14200.0 -0.36 0.8729 0.5334 3069046 SPBio_002235 NCC1OC(COC[C@@H]2C(O)[C@H](OC3C(O)C(N)CC(N)C3OC4OC(CN)C(O)C(O)C4N)O[C@@H]2CO)C(N)C(O)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P18 compound treatment 289840.0 61600.0 1.64 185560.0 -27500.0 -0.7 0.6666 0.3735 999 SPBio_002236 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P19 compound treatment 279720.0 51500.0 1.37 222640.0 9580.0 0.24 1.1424 0.8198 3069047 SPBio_002237 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P20 compound treatment 256200.0 27900.0 0.75 204360.0 -8700.0 -0.22 0.3703 0.4765 1443 SPBio_002238 CN(C)CCOC(c1ccccc1)c2ccccc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P21 compound treatment 276960.0 48700.0 1.3 246000.0 32900.0 0.84 1.5104 0.9775 3189062 SPBio_002239 CN[C@H](C)[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@@H](CC[C@H]3N)[C@@H](C)N)[C@@H]2O)OC[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P22 compound treatment 288040.0 59800.0 1.59 233000.0 19900.0 0.51 1.4856 0.8882 1291 SPBio_002240 CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P23 mock treatment 256760.0 28500.0 0.76 228280.0 15200.0 0.39 0.811 0.951 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2164 P24 mock treatment 247440.0 19200.0 0.51 194080.0 -19000.0 -0.48 0.0204 0.029 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A01 mock treatment 220480.0 -6420.0 -0.17 232360.0 13200.0 0.34 0.1168 0.3095 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A02 mock treatment 209200.0 -17700.0 -0.47 247800.0 28700.0 0.73 0.1817 0.2093 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A03 compound treatment 227320.0 421.0 0.01 237400.0 18300.0 0.46 0.3363 0.724 1425 SPBio_002241 CC(N)COc1c(C)cccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A04 compound treatment 219800.0 -7100.0 -0.19 251680.0 32500.0 0.83 0.4513 0.5316 3189183 SPBio_002242 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A05 compound treatment 221480.0 -5420.0 -0.14 236560.0 17400.0 0.44 0.2111 0.453 3101 SPBio_002243 Cc1c(oc2c(cccc2c1=O)C(=O)OCCN3CCCCC3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A06 compound treatment 219800.0 -7100.0 -0.19 249840.0 30700.0 0.78 0.4182 0.5206 3480229 SPBio_002244 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A07 compound treatment 180760.0 -46100.0 -1.23 197440.0 -21700.0 -0.55 -1.2599 -0.9345 769 SPBio_002245 CCCCOc1ccc(CC(=O)NO)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A08 compound treatment 235800.0 8900.0 0.24 242440.0 23300.0 0.59 0.5868 0.9193 1132 SPBio_002246 CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A09 compound treatment 222360.0 -4540.0 -0.12 235400.0 16300.0 0.41 0.2069 0.4801 1469 SPBio_002247 CCC1(CCC(=O)NC1=O)c2ccc(N)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A10 compound treatment 217160.0 -9740.0 -0.26 256360.0 37200.0 0.95 0.4857 0.4948 3068879 SPBio_002248 C[C@@H](N)[C@H](O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A11 compound treatment 225360.0 -1540.0 -0.04 241520.0 22400.0 0.57 0.3735 0.6544 858 SPBio_002249 OCC(O)CN1CCN(CC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A12 compound treatment 233320.0 6420.0 0.17 255280.0 36100.0 0.92 0.7709 0.8246 3068880 SPBio_002250 OCC(O)[C@H]1OC(=O)C(O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A13 compound treatment 215520.0 -11400.0 -0.3 225080.0 5950.0 0.15 -0.1076 -0.3175 3173239 SPBio_002251 CC(N/C(=N/C#N)/Nc1ccncc1)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A14 compound treatment 206480.0 -20400.0 -0.54 221440.0 2310.0 0.06 -0.3435 -0.6273 800 SPBio_002252 C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A15 compound treatment 115320.0 -112000.0 -2.97 136360.0 -82800.0 -2.1 -3.5918 -0.9856 1185085 SPBio_002253 CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A16 compound treatment 218840.0 -8060.0 -0.21 244200.0 25100.0 0.64 0.2987 0.4441 3063 SPBio_002254 CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4C)c5ccc(O)cc5)C(=O)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A17 compound treatment 214720.0 -12200.0 -0.32 229200.0 10100.0 0.26 -0.0486 -0.1176 448 SPBio_002255 Clc1cccc(Cl)c1N=C2NCCN2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A18 compound treatment 206080.0 -20800.0 -0.56 238760.0 19600.0 0.5 -0.0396 -0.0531 3173242 SPBio_002256 Nc1nc2cc(Cl)ccc2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A19 compound treatment 208400.0 -18500.0 -0.49 228280.0 9150.0 0.23 -0.1843 -0.338 1101055 SPBio_002257 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A20 compound treatment 215120.0 -11800.0 -0.31 229120.0 9990.0 0.25 -0.0425 -0.1053 1516 SPBio_002258 Nc1c2CCCCc2nc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A21 compound treatment 225880.0 -1020.0 -0.03 248880.0 29700.0 0.76 0.5156 0.6813 690 SPBio_002259 CC(C)NCC(O)COc1ccccc1CC=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A22 compound treatment 241560.0 14700.0 0.39 241080.0 21900.0 0.56 0.671 0.9848 3487402 SPBio_002260 CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A23 mock treatment 242880.0 16000.0 0.43 230960.0 11800.0 0.3 0.5139 0.9854 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 A24 mock treatment 240000.0 13100.0 0.35 204920.0 -14200.0 -0.36 -0.0086 -0.017 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B01 mock treatment 233280.0 6380.0 0.17 290160.0 71000.0 1.81 1.3973 0.7703 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B02 mock treatment 218600.0 -8300.0 -0.22 235040.0 15900.0 0.4 0.1295 0.2809 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B03 compound treatment 184560.0 -42300.0 -1.13 229040.0 9910.0 0.25 -0.6201 -0.5362 2717 SPBio_002261 CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B04 compound treatment 214400.0 -12500.0 -0.33 229840.0 10700.0 0.27 -0.0432 -0.1003 429 SPBio_002262 NCCc1c[nH]c2ccc(O)cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B05 compound treatment 202360.0 -24500.0 -0.65 228560.0 9430.0 0.24 -0.2932 -0.4207 1403 SPBio_002263 COC(=O)C1=CCCN(C)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B06 compound treatment 218320.0 -8580.0 -0.23 234320.0 15200.0 0.39 0.1113 0.248 1000242 SPBio_002264 CN(C)CCn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4csc(N)n4)C3=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B07 compound treatment 199400.0 -27500.0 -0.73 243040.0 23900.0 0.61 -0.0886 -0.0931 1000219 SPBio_002265 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B08 compound treatment 218920.0 -7980.0 -0.21 240160.0 21000.0 0.53 0.2276 0.3956 3189438 SPBio_002266 Cc1n[nH]c(=O)[nH]c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B09 compound treatment 229240.0 2340.0 0.06 239880.0 20700.0 0.53 0.4171 0.7853 1001661 SPBio_002267 CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B10 compound treatment 201240.0 -25700.0 -0.68 227520.0 8390.0 0.21 -0.333 -0.4647 1077918 SPBio_002268 Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B11 compound treatment 231480.0 4580.0 0.12 243640.0 24500.0 0.62 0.527 0.8299 3189307 SPBio_002269 CC(C)CC(NC(=O)[C@H](C)NC(=O)C[C@H](O)C(CC(C)C)NC(=O)[C@@H](NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B12 compound treatment 228080.0 1180.0 0.03 230240.0 11100.0 0.28 0.2219 0.7811 3173761 SPBio_002270 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B13 compound treatment 222160.0 -4740.0 -0.13 244200.0 25100.0 0.64 0.3613 0.5561 3068973 SPBio_002271 C(CN1CCOCC1)Nc2cc3CCCc4ccccc4-c3nn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B14 compound treatment 220320.0 -6580.0 -0.18 233440.0 14300.0 0.36 0.1332 0.3298 3189439 SPBio_002272 CC(C)CCCCC(=O)N[C@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CCN)C(=O)N[C@@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CNC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)C)[C@@H](C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B15 compound treatment 208200.0 -18700.0 -0.5 228120.0 8990.0 0.23 -0.191 -0.3482 1408 SPBio_002273 NC1(CC2CC3CC(C2)C1)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B16 compound treatment 56480.0 -170000.0 -4.54 78480.0 -141000.0 -3.58 -5.7418 -0.993 2117312 SPBio_002274 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B17 compound treatment 12840.0 -214000.0 -5.71 16320.0 -203000.0 -5.16 -7.6822 -0.9987 3068976 SPBio_002275 Clc1ccc(CCC(Cn2ccnc2)Sc3c(Cl)cccc3Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B18 compound treatment 174560.0 -52300.0 -1.4 224280.0 5150.0 0.13 -0.8942 -0.638 2911 SPBio_002276 CN(C)CC/C=C\1/c2ccccc2CSc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B19 compound treatment 29760.0 -197000.0 -5.26 63360.0 -156000.0 -3.96 -6.5174 -0.9903 26 SPBio_002277 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B20 compound treatment 214280.0 -12600.0 -0.34 235480.0 16300.0 0.42 0.056 0.1047 3189440 SPBio_002278 CC(C)(O/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C[n+]3ccccc3)\c4csc(N)n4)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B21 compound treatment 219440.0 -7460.0 -0.2 251880.0 32700.0 0.83 0.4481 0.5235 2081486 SPBio_002279 CC1OC(O[C@@H]/2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(=O)O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C2)C(O)C(N)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B22 compound treatment 227120.0 221.0 0.01 245480.0 26300.0 0.67 0.4778 0.7133 3060173 SPBio_002280 NC(=N)NCc1cccc(I)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B23 mock treatment 239440.0 12500.0 0.33 252680.0 33500.0 0.85 0.8396 0.9164 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 B24 mock treatment 260720.0 33800.0 0.9 252360.0 33200.0 0.84 1.235 0.9995 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C01 mock treatment 221280.0 -5620.0 -0.15 218280.0 -854.0 -0.02 -0.1213 -0.8012 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C02 mock treatment 212960.0 -13900.0 -0.37 229000.0 9870.0 0.25 -0.0854 -0.1905 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C03 compound treatment 202400.0 -24500.0 -0.65 222760.0 3630.0 0.09 -0.3967 -0.6013 1282 SPBio_002281 NS(=O)(=O)c1cc2c(N=CNS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C04 compound treatment 202040.0 -24900.0 -0.66 216000.0 -3130.0 -0.08 -0.525 -0.7865 907527 SPBio_002282 C(C#CCN1CCCC1)N2CCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C05 compound treatment 200600.0 -26300.0 -0.7 204760.0 -14400.0 -0.37 -0.7543 -0.9539 3036 SPBio_002283 OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C06 compound treatment 199320.0 -27600.0 -0.74 229840.0 10700.0 0.27 -0.3275 -0.4176 1486 SPBio_002284 CC(C)NCC(O)COc1ccc(NC(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C07 compound treatment 186640.0 -40300.0 -1.07 211840.0 -7290.0 -0.19 -0.8902 -0.8172 1000286 SPBio_002285 C[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C08 compound treatment 194320.0 -32600.0 -0.87 216280.0 -2850.0 -0.07 -0.6655 -0.7635 3189185 SPBio_002286 Cc1cn([C@H]2C[C@@H](N=[N+]=N)[C@@H](CO)O2)c(=O)[nH]c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C09 compound treatment 170280.0 -56600.0 -1.51 212800.0 -6330.0 -0.16 -1.1813 -0.7781 809 SPBio_002287 CNCCC=C1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C10 compound treatment 208840.0 -18100.0 -0.48 216240.0 -2890.0 -0.07 -0.3925 -0.8058 1192 SPBio_002288 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C11 compound treatment 182760.0 -44100.0 -1.18 203040.0 -16100.0 -0.41 -1.1215 -0.9001 112 SPBio_002289 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C12 compound treatment 224320.0 -2580.0 -0.07 253440.0 34300.0 0.87 0.5682 0.6493 3068881 SPBio_002290 CCCOc1ccccc1c2nc(=O)c3[nH]nnc3[nH]2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C13 compound treatment 214440.0 -12500.0 -0.33 257520.0 38400.0 0.98 0.4553 0.4416 1000009 SPBio_002291 C/C(=C\C=C\C(=C/C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C14 compound treatment 209320.0 -17600.0 -0.47 215320.0 -3810.0 -0.1 -0.4 -0.8357 1471 SPBio_002292 CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C15 compound treatment 168080.0 -58800.0 -1.57 211880.0 -7250.0 -0.18 -1.2394 -0.7849 104 SPBio_002293 C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C16 compound treatment 207880.0 -19000.0 -0.51 235320.0 16200.0 0.41 -0.0676 -0.1034 2431 SPBio_002294 CCN(CC)CCNC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C17 compound treatment 200960.0 -25900.0 -0.69 208640.0 -10500.0 -0.27 -0.6777 -0.9142 746 SPBio_002295 C(N(Cc1ccccc1)c2ccccc2)C3=NCCN3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C18 compound treatment 188360.0 -38500.0 -1.03 231840.0 12700.0 0.32 -0.4981 -0.4625 3189186 SPBio_002296 CNc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C19 compound treatment 56600.0 -170000.0 -4.54 115720.0 -103000.0 -2.63 -5.07 -0.9663 1485 SPBio_002297 CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C20 compound treatment 152280.0 -74600.0 -1.99 191040.0 -28100.0 -0.71 -1.9119 -0.9045 3368 SPBio_002298 NC(=N)NC(=O)Cc1c(Cl)cccc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C21 compound treatment 197400.0 -29500.0 -0.79 245160.0 26000.0 0.66 -0.0882 -0.0858 1000106 SPBio_002299 O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C22 compound treatment 73400.0 -153000.0 -4.09 102640.0 -116000.0 -2.96 -4.9884 -0.9874 1001939 SPBio_002300 OCCN1CCN(CC/C=C\2/c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C23 mock treatment 208560.0 -18300.0 -0.49 220080.0 946.0 0.02 -0.3287 -0.6715 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 C24 mock treatment 228000.0 1100.0 0.03 230240.0 11100.0 0.28 0.2204 0.7764 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D01 mock treatment 217000.0 -9900.0 -0.26 227480.0 8350.0 0.21 -0.0366 -0.108 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D02 mock treatment 208800.0 -18100.0 -0.48 230160.0 11000.0 0.28 -0.143 -0.2562 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D03 compound treatment 216800.0 -10100.0 -0.27 223960.0 4830.0 0.12 -0.1036 -0.3502 3189308 SPBio_002301 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D04 compound treatment 161400.0 -65500.0 -1.75 212680.0 -6450.0 -0.16 -1.3509 -0.7702 2120971 SPBio_002302 CN1CCCC(CC2c3ccccc3Sc4ccccc24)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D05 compound treatment 20560.0 -206000.0 -5.5 28080.0 -191000.0 -4.86 -7.3252 -0.9981 2117676 SPBio_002303 COc1ccc(C[C@@H]2NC[C@@H](O)[C@@H]2OC(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D06 compound treatment 221000.0 -5900.0 -0.16 256880.0 37700.0 0.96 0.5674 0.5834 3172716 SPBio_002304 NC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D07 compound treatment 216240.0 -10700.0 -0.28 214080.0 -5050.0 -0.13 -0.2918 -0.9356 1023517 SPBio_002305 NC(=O)Nc1ccc(cc1)[As](=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D08 compound treatment 214840.0 -12100.0 -0.32 227000.0 7870.0 0.2 -0.0859 -0.2269 1782 SPBio_002306 COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D09 compound treatment 178680.0 -48200.0 -1.29 227800.0 8670.0 0.22 -0.7533 -0.5775 360 SPBio_002307 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D10 compound treatment 201520.0 -25400.0 -0.68 226320.0 7190.0 0.18 -0.3493 -0.4983 912 SPBio_002308 CCCc1cc(=O)[nH]c(=S)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D11 compound treatment 215600.0 -11300.0 -0.3 230240.0 11100.0 0.28 -0.0133 -0.0323 1064663 SPBio_002309 CC(=O)NC(CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D12 compound treatment 190920.0 -36000.0 -0.96 201400.0 -17700.0 -0.45 -0.9972 -0.9407 3189441 SPBio_002310 CC(C)N1CCN(CC1)c2ccc(OC[C@@H]3CO[C@](Cn4cncn4)(O3)c5ccc(Cl)cc5Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D13 compound treatment 220160.0 -6740.0 -0.18 227920.0 8790.0 0.22 0.0309 0.1078 3189309 SPBio_002311 CCOC(=O)OC(C)OC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D14 compound treatment 158280.0 -68600.0 -1.83 164040.0 -55100.0 -1.4 -2.2842 -0.9913 3487464 SPBio_002312 CC(C(=O)O)c1ccc(s1)C(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D15 compound treatment 69840.0 -157000.0 -4.19 161160.0 -58000.0 -1.47 -4.0034 -0.9018 1960 SPBio_002313 CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D16 compound treatment 205920.0 -21000.0 -0.56 224280.0 5150.0 0.13 -0.303 -0.5275 3177604 SPBio_002314 CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@H](NC6=O)C(=O)O)c3O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D17 compound treatment 195520.0 -31400.0 -0.84 228400.0 9270.0 0.24 -0.425 -0.489 951 SPBio_002315 OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D18 compound treatment 189800.0 -37100.0 -0.99 214120.0 -5010.0 -0.13 -0.7896 -0.7917 1263 SPBio_002316 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D19 compound treatment 174680.0 -52200.0 -1.39 199840.0 -19300.0 -0.49 -1.3314 -0.9019 982 SPBio_002317 CC(=O)Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D20 compound treatment 197360.0 -29500.0 -0.79 209160.0 -9970.0 -0.25 -0.7362 -0.8898 1489 SPBio_002318 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D21 compound treatment 199160.0 -27700.0 -0.74 223640.0 4510.0 0.11 -0.442 -0.5905 3189310 SPBio_002319 CC(C)[C@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@H](O)CCC3=C)\CCC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D22 compound treatment 208520.0 -18400.0 -0.49 215840.0 -3290.0 -0.08 -0.4057 -0.8161 1113307 SPBio_002320 CCN(CC)C(=O)c1ccc(O)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D23 mock treatment 222600.0 -4300.0 -0.11 212200.0 -6930.0 -0.18 -0.2057 -0.9783 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 D24 mock treatment 211680.0 -15200.0 -0.41 222840.0 3710.0 0.09 -0.2203 -0.5288 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E01 mock treatment 228960.0 2060.0 0.05 240480.0 21300.0 0.54 0.4226 0.7747 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E02 mock treatment 227000.0 101.0 0.0 236800.0 17700.0 0.45 0.3195 0.7113 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E03 compound treatment 238960.0 12100.0 0.32 223840.0 4710.0 0.12 0.312 0.9093 3189178 SPBio_002321 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E04 compound treatment 218440.0 -8460.0 -0.23 229080.0 9950.0 0.25 0.0193 0.0571 1188 SPBio_002322 NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E05 compound treatment 220680.0 -6220.0 -0.17 224200.0 5070.0 0.13 -0.0262 -0.1246 938 SPBio_002323 Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E06 compound treatment 210720.0 -16200.0 -0.43 243080.0 23900.0 0.61 0.1255 0.1682 1510 SPBio_002324 CN(C)CCN(Cc1cccs1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E07 compound treatment 219880.0 -7020.0 -0.19 247080.0 27900.0 0.71 0.3701 0.5037 3060494 SPBio_002325 CN(C)CC/C=C/1\c2ccccc2COc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E08 compound treatment 221680.0 -5220.0 -0.14 240040.0 20900.0 0.53 0.2775 0.505 844 SPBio_002326 CNCCCN1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E09 compound treatment 57080.0 -170000.0 -4.53 69880.0 -149000.0 -3.8 -5.8851 -0.9961 1240 SPBio_002327 CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E10 compound treatment 201920.0 -25000.0 -0.67 253080.0 33900.0 0.86 0.1394 0.1279 2203 SPBio_002328 CN(CCCOc1ccc(Cl)cc1Cl)CC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E11 compound treatment 235240.0 8340.0 0.22 245880.0 26700.0 0.68 0.6381 0.8919 3189179 SPBio_002329 CN(C)CCOC(c1ccccc1)c2ccccc2.Cn1c(=O)n(C)c2nc(Cl)[n-]c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E12 compound treatment 216240.0 -10700.0 -0.28 225240.0 6110.0 0.16 -0.0912 -0.2815 1390 SPBio_002330 CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E13 compound treatment 220680.0 -6220.0 -0.17 251200.0 32100.0 0.82 0.4593 0.552 1112 SPBio_002331 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E14 compound treatment 205880.0 -21000.0 -0.56 244400.0 25300.0 0.64 0.058 0.068 1476 SPBio_002332 CNCCCC1(CCC2c3ccccc31)c4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E15 compound treatment 17160.0 -210000.0 -5.59 53680.0 -165000.0 -4.21 -6.929 -0.9902 1272 SPBio_002333 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E16 compound treatment 85440.0 -141000.0 -3.77 98600.0 -121000.0 -3.06 -4.8341 -0.9947 3189187 SPBio_002334 Nc1nc(S)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E17 compound treatment 222760.0 -4140.0 -0.11 234720.0 15600.0 0.4 0.2022 0.4915 2359 SPBio_002335 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@@H]32)n1c5ccccc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E18 compound treatment 213960.0 -12900.0 -0.34 235040.0 15900.0 0.4 0.042 0.0791 3068882 SPBio_002336 CN(C)CC/C=C\1/c2ccccc2Sc3ccc(Cl)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E19 compound treatment 224440.0 -2460.0 -0.07 247840.0 28700.0 0.73 0.4698 0.641 1393 SPBio_002337 CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E20 compound treatment 215360.0 -11500.0 -0.31 216080.0 -3050.0 -0.08 -0.2725 -0.8586 1000292 SPBio_002338 C[C@H](NCCc1ccc(O)cc1)[C@H](O)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E21 compound treatment 77560.0 -149000.0 -3.98 169160.0 -50000.0 -1.27 -3.714 -0.8886 1215 SPBio_002339 CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E22 compound treatment 210680.0 -16200.0 -0.43 229000.0 9870.0 0.25 -0.1284 -0.2568 417 SPBio_002340 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E23 mock treatment 200080.0 -26800.0 -0.72 209520.0 -9610.0 -0.24 -0.6785 -0.8978 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 E24 mock treatment 208600.0 -18300.0 -0.49 225720.0 6590.0 0.17 -0.2266 -0.4393 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F01 mock treatment 210240.0 -16700.0 -0.44 261520.0 42400.0 1.08 0.448 0.3843 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F02 mock treatment 224040.0 -2860.0 -0.08 239840.0 20700.0 0.53 0.3184 0.5985 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F03 compound treatment 22480.0 -204000.0 -5.45 35120.0 -184000.0 -4.68 -7.1624 -0.9971 998 SPBio_002341 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F04 compound treatment 213600.0 -13300.0 -0.35 237680.0 18500.0 0.47 0.0827 0.1402 1002022 SPBio_002342 NC(CCC(=O)O)C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F05 compound treatment 231920.0 5020.0 0.13 226880.0 7750.0 0.2 0.2339 0.9823 3069011 SPBio_002343 NCCC(=O)NCCc1c[nH]cn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F06 compound treatment 214920.0 -12000.0 -0.32 267640.0 48500.0 1.23 0.6463 0.5073 2121358 SPBio_002344 OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F07 compound treatment 220680.0 -6220.0 -0.17 277840.0 58700.0 1.49 0.9382 0.6247 1409 SPBio_002345 CCCC(C)(COC(=O)N)COC(=O)NC(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F08 compound treatment 239440.0 12500.0 0.33 259760.0 40600.0 1.03 0.9669 0.8905 3487465 SPBio_002346 OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F09 compound treatment 238640.0 11700.0 0.31 281280.0 62100.0 1.58 1.3387 0.831 3189311 SPBio_002347 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](N)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F10 compound treatment 239960.0 13100.0 0.35 228080.0 8950.0 0.23 0.4071 0.9787 3189442 SPBio_002348 CCc1cccc(CC)c1NC(=O)CN(CC(=O)O)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F11 compound treatment 177200.0 -49700.0 -1.33 210200.0 -8930.0 -0.23 -1.0976 -0.8164 2117409 SPBio_002349 COc1cc(ccc1N=Nc2ccc3c(cc(c(N)c3c2O)S(=O)(=O)O)S(=O)(=O)O)c4ccc(N=Nc5ccc6c(cc(c(N)c6c5O)S(=O)(=O)O)S(=O)(=O)O)c(OC)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F12 compound treatment 245000.0 18100.0 0.48 233760.0 14600.0 0.37 0.6042 0.9917 1252 SPBio_002350 CC(C)NCC(O)c1cc(O)cc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F13 compound treatment 262800.0 35900.0 0.96 264840.0 45700.0 1.16 1.4986 0.9954 907205 SPBio_002351 COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F14 compound treatment 228920.0 2020.0 0.05 237360.0 18200.0 0.46 0.3658 0.784 2080587 SPBio_002352 CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(=CCC3N)CN)C2O)OCC1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F15 compound treatment 221880.0 -5020.0 -0.13 249360.0 30200.0 0.77 0.4488 0.5753 3173763 SPBio_002353 O[C@@H]1C[C@](O)(C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H]1O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F16 compound treatment 215280.0 -11600.0 -0.31 253520.0 34400.0 0.87 0.3992 0.4303 353 SPBio_002354 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F17 compound treatment 52000.0 -175000.0 -4.66 58280.0 -161000.0 -4.09 -6.1895 -0.9979 3180147 SPBio_002355 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]4NCCc5cc(O)c(OC)cc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F18 compound treatment 84640.0 -142000.0 -3.79 151680.0 -67500.0 -1.72 -3.8948 -0.9356 2269 SPBio_002356 Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F19 compound treatment 215040.0 -11900.0 -0.32 266840.0 47700.0 1.21 0.6341 0.5059 3189312 SPBio_002357 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C\3/C[C@H](O)CCC3=C)/CCC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F20 compound treatment 194720.0 -32200.0 -0.86 217400.0 -1730.0 -0.04 -0.6379 -0.7425 2922 SPBio_002358 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Br)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F21 compound treatment 202760.0 -24100.0 -0.64 255360.0 36200.0 0.92 0.1962 0.1746 3487430 SPBio_002359 COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c3cc(Cl)c(N)cc3OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F22 compound treatment 214320.0 -12600.0 -0.34 227920.0 8790.0 0.22 -0.0792 -0.1965 1000807 SPBio_002360 CN1CCN(CC1)C(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F23 mock treatment 203440.0 -23500.0 -0.63 211840.0 -7290.0 -0.19 -0.5734 -0.8789 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 F24 mock treatment 225080.0 -1820.0 -0.05 202080.0 -17100.0 -0.43 -0.3409 -0.7813 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G01 mock treatment 222560.0 -4340.0 -0.12 218600.0 -534.0 -0.01 -0.0914 -0.7847 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G02 mock treatment 199880.0 -27000.0 -0.72 217920.0 -1210.0 -0.03 -0.5312 -0.7367 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G03 compound treatment 197120.0 -29800.0 -0.79 253320.0 34200.0 0.87 0.0532 0.0452 3069234 SPBio_002361 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@](O)(C(=O)OC)n4c5ccccc35 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G04 compound treatment 213360.0 -13500.0 -0.36 221000.0 1870.0 0.05 -0.2217 -0.6089 1332 SPBio_002362 NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G05 compound treatment 223240.0 -3660.0 -0.1 229840.0 10700.0 0.27 0.1235 0.4271 2797 SPBio_002363 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G06 compound treatment 220000.0 -6900.0 -0.18 238480.0 19300.0 0.49 0.2178 0.4146 3480458 SPBio_002364 CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G07 compound treatment 227680.0 781.0 0.02 244240.0 25100.0 0.64 0.4661 0.7298 3176928 SPBio_002365 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G08 compound treatment 237760.0 10900.0 0.29 261840.0 42700.0 1.09 0.9726 0.8654 1048 SPBio_002366 CCn1cc(C(=O)O)c(=O)c2cc(F)c(nc12)N3CCNCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G09 compound treatment 236640.0 9740.0 0.26 228200.0 9070.0 0.23 0.3466 0.9982 3189180 SPBio_002367 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G10 compound treatment 233960.0 7060.0 0.19 237920.0 18800.0 0.48 0.4709 0.9171 1526 SPBio_002368 CC1CCCC(C)N1NC(=O)c2ccc(Cl)c(c2)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G11 compound treatment 209600.0 -17300.0 -0.46 253960.0 34800.0 0.89 0.3 0.3005 1172 SPBio_002369 CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G12 compound treatment 186040.0 -40900.0 -1.09 225840.0 6710.0 0.17 -0.6498 -0.5893 1105 SPBio_002370 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G13 compound treatment 245280.0 18400.0 0.49 237280.0 18100.0 0.46 0.6728 0.9995 404 SPBio_002371 CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G14 compound treatment 238280.0 11400.0 0.3 269240.0 50100.0 1.27 1.1154 0.8517 3068883 SPBio_002372 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G15 compound treatment 250240.0 23300.0 0.62 230160.0 11000.0 0.28 0.6383 0.9351 1100 SPBio_002373 CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G16 compound treatment 231280.0 4380.0 0.12 216960.0 -2170.0 -0.06 0.0435 0.3367 3189189 SPBio_002374 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G17 compound treatment 191240.0 -35700.0 -0.95 202240.0 -16900.0 -0.43 -0.976 -0.9355 3172 SPBio_002375 C(/C=C/c1ccccc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G18 compound treatment 229880.0 2980.0 0.08 212880.0 -6250.0 -0.16 -0.0562 -0.3164 1000342 SPBio_002376 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G19 compound treatment 235080.0 8180.0 0.22 207920.0 -11200.0 -0.29 -0.0474 -0.132 1001967 SPBio_002377 C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G20 compound treatment 226960.0 61.0 0.0 252880.0 33700.0 0.86 0.6079 0.7084 1000343 SPBio_002378 COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G21 compound treatment 182600.0 -44300.0 -1.18 234000.0 14900.0 0.38 -0.5679 -0.4579 3177396 SPBio_002379 COc1ccc2nccc([C@H](O)[C@H]3CC4CCN3C[C@@H]4C=C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G22 compound treatment 220920.0 -5980.0 -0.16 221120.0 1990.0 0.05 -0.077 -0.4606 764 SPBio_002380 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)n3c(=O)[nH]c4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G23 mock treatment 221160.0 -5740.0 -0.15 215680.0 -3450.0 -0.09 -0.1703 -0.9653 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 G24 mock treatment 216080.0 -10800.0 -0.29 205840.0 -13300.0 -0.34 -0.443 -0.9969 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H01 mock treatment 238040.0 11100.0 0.3 222440.0 3310.0 0.08 0.2695 0.8729 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H02 mock treatment 214440.0 -12500.0 -0.33 222480.0 3350.0 0.09 -0.1747 -0.5096 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H03 compound treatment 208320.0 -18600.0 -0.5 245720.0 26600.0 0.68 0.1277 0.1524 1055132 SPBio_002381 COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H04 compound treatment 195520.0 -31400.0 -0.84 228160.0 9030.0 0.23 -0.4293 -0.4949 1095093 SPBio_002382 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H05 compound treatment 228440.0 1540.0 0.04 225320.0 6190.0 0.16 0.1403 0.8629 3054850 SPBio_002383 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H06 compound treatment 234320.0 7420.0 0.2 247000.0 27900.0 0.71 0.6409 0.8712 2141046 SPBio_002384 CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H07 compound treatment 207160.0 -19700.0 -0.53 214200.0 -4930.0 -0.13 -0.4609 -0.8518 3189313 SPBio_002385 C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(=O)N)[C@H]2N=C1/C(=C/3\N=C(/C=C/4\N=C(/C(=C\5/[C@@H](CCC(=O)N)[C@](C)(CC(=O)N)[C@@]2(C)N5[Co+]C#N)/C)\[C@@](C)(CC(=O)N)[C@@H]4CCC(=O)N)\C(C)(C)[C@@H]3CCC(=O)N)/C)OP(=O)(O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H08 compound treatment 231040.0 4140.0 0.11 224360.0 5230.0 0.13 0.172 0.9958 3068692 SPBio_002386 CNCCC=C1c2ccccc2C=Cc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H09 compound treatment 235600.0 8700.0 0.23 247160.0 28000.0 0.71 0.6679 0.8913 1037 SPBio_002387 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H10 compound treatment 240800.0 13900.0 0.37 240720.0 21600.0 0.55 0.6502 0.9817 889 SPBio_002388 NC(=O)c1cnccn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H11 compound treatment 240360.0 13500.0 0.36 259320.0 40200.0 1.02 0.9763 0.9015 3069049 SPBio_002389 CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C/C=C/C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H12 compound treatment 238360.0 11500.0 0.31 250200.0 31100.0 0.79 0.7746 0.9146 2900 SPBio_002390 CN1C(=O)OC(C)(C)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H13 compound treatment 34640.0 -192000.0 -5.13 35800.0 -183000.0 -4.66 -6.9209 -0.9989 3189314 SPBio_002391 C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)CC[C@@H]1C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H14 compound treatment 69000.0 -158000.0 -4.21 95960.0 -123000.0 -3.13 -5.1915 -0.9894 1607 SPBio_002392 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H15 compound treatment 34480.0 -192000.0 -5.13 32440.0 -187000.0 -4.75 -6.9844 -0.9992 3189315 SPBio_002393 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H16 compound treatment 250200.0 23300.0 0.62 227680.0 8550.0 0.22 0.593 0.9009 3189443 SPBio_002394 CC1OC(OC/2CC3O[C@@](O)(CC(O)C3C(=O)O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)/C=C/C=C/CC\C=C\C=C\C=C\C=C2)C(O)C(N)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H17 compound treatment 101000.0 -126000.0 -3.36 97040.0 -122000.0 -3.1 -4.5688 -0.9992 1000279 SPBio_002395 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H18 compound treatment 251440.0 24500.0 0.65 234320.0 15200.0 0.39 0.7357 0.9683 3060147 SPBio_002396 CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H19 compound treatment 253320.0 26400.0 0.7 222360.0 3230.0 0.08 0.5561 0.7841 3069053 SPBio_002397 CCOC(=O)n1ccn(C)c1=S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H20 compound treatment 241200.0 14300.0 0.38 221080.0 1950.0 0.05 0.3046 0.7922 3068724 SPBio_002398 C[C@@H](O)[C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCNC=N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H21 compound treatment 211880.0 -15000.0 -0.4 231960.0 12800.0 0.33 -0.0526 -0.1018 1001924 SPBio_002399 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H22 compound treatment 223240.0 -3660.0 -0.1 237720.0 18600.0 0.47 0.2652 0.5495 1448 SPBio_002400 OC(=O)c1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H23 mock treatment 223720.0 -3180.0 -0.08 228320.0 9190.0 0.23 0.1052 0.4235 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 H24 mock treatment 238880.0 12000.0 0.32 186080.0 -33100.0 -0.84 -0.3684 -0.4097 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I01 mock treatment 220280.0 -6620.0 -0.18 200680.0 -18500.0 -0.47 -0.4566 -0.9108 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I02 mock treatment 211360.0 -15500.0 -0.41 218160.0 -974.0 -0.02 -0.3105 -0.748 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I03 compound treatment 203440.0 -23500.0 -0.63 230240.0 11100.0 0.28 -0.2426 -0.3535 1000235 SPBio_002401 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I04 compound treatment 209400.0 -17500.0 -0.47 226800.0 7670.0 0.19 -0.1921 -0.3799 3189191 SPBio_002402 CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I05 compound treatment 230760.0 3860.0 0.1 239200.0 20100.0 0.51 0.4336 0.833 1033 SPBio_002403 CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I06 compound treatment 215800.0 -11100.0 -0.3 237720.0 18600.0 0.47 0.1249 0.224 3068885 SPBio_002404 C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I07 compound treatment 199040.0 -27900.0 -0.74 216640.0 -2490.0 -0.06 -0.5701 -0.7647 1019722 SPBio_002405 CN1CCCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I08 compound treatment 155080.0 -71800.0 -1.91 157960.0 -61200.0 -1.56 -2.4539 -0.9947 1352 SPBio_002406 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I09 compound treatment 220640.0 -6260.0 -0.17 255880.0 36700.0 0.93 0.5427 0.5718 1164 SPBio_002407 CCN(CC)C(=O)N1CCN(C)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I10 compound treatment 221600.0 -5300.0 -0.14 220840.0 1710.0 0.04 -0.0692 -0.4684 3177235 SPBio_002408 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]3[C@H]1Cc4cn(C)c5cccc3c45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I11 compound treatment 253000.0 26100.0 0.7 247000.0 27900.0 0.71 0.9931 1.0 1000071 SPBio_002409 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I12 compound treatment 239400.0 12500.0 0.33 224960.0 5830.0 0.15 0.3404 0.9333 3189192 SPBio_002410 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I13 compound treatment 54680.0 -172000.0 -4.59 131840.0 -87300.0 -2.22 -4.8164 -0.9444 1158 SPBio_002411 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I14 compound treatment 231080.0 4180.0 0.11 211960.0 -7170.0 -0.18 -0.0502 -0.2346 701 SPBio_002412 Nc1c(Br)cc(Br)cc1CNC2CCC(O)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I15 compound treatment 225160.0 -1740.0 -0.05 220840.0 1710.0 0.04 -0.0021 -0.0333 3480597 SPBio_002413 CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I16 compound treatment 210400.0 -16500.0 -0.44 201760.0 -17400.0 -0.44 -0.6234 -1.0 705 SPBio_002414 CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I17 compound treatment 255440.0 28500.0 0.76 247440.0 28300.0 0.72 1.047 0.9996 1180 SPBio_002415 Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I18 compound treatment 177160.0 -49700.0 -1.33 170320.0 -48800.0 -1.24 -1.8154 -0.9995 1000048 SPBio_002416 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I19 compound treatment 231280.0 4380.0 0.12 223200.0 4070.0 0.1 0.1557 0.9981 830 SPBio_002417 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I20 compound treatment 207080.0 -19800.0 -0.53 197120.0 -22000.0 -0.56 -0.7694 -0.9996 1504 SPBio_002418 O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I21 compound treatment 209560.0 -17300.0 -0.46 232280.0 13100.0 0.33 -0.0905 -0.1587 753 SPBio_002419 O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I22 compound treatment 28520.0 -198000.0 -5.29 38000.0 -181000.0 -4.61 -6.9968 -0.9976 2873 SPBio_002420 CCc1oc2ccccc2c1C(=O)c3cc(Br)c(O)c(Br)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I23 mock treatment 200200.0 -26700.0 -0.71 201280.0 -17900.0 -0.45 -0.8244 -0.9764 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 I24 mock treatment 222600.0 -4300.0 -0.11 182680.0 -36500.0 -0.93 -0.7365 -0.7885 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J01 mock treatment 215160.0 -11700.0 -0.31 211920.0 -7210.0 -0.18 -0.351 -0.9676 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J02 mock treatment 208440.0 -18500.0 -0.49 224360.0 5230.0 0.13 -0.2541 -0.4984 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J03 compound treatment 184520.0 -42400.0 -1.13 191160.0 -28000.0 -0.71 -1.3019 -0.9751 386 SPBio_002421 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2CC[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J04 compound treatment 218360.0 -8540.0 -0.23 228840.0 9710.0 0.25 0.0135 0.0403 821975 SPBio_002422 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J05 compound treatment 212080.0 -14800.0 -0.4 216840.0 -2290.0 -0.06 -0.3206 -0.8028 2078 SPBio_002423 CCCCc1ccc(nc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J06 compound treatment 35080.0 -192000.0 -5.11 43800.0 -175000.0 -4.46 -6.7688 -0.9977 3189444 SPBio_002424 CCC(C)C1NC2C=Cc3c(cc(nc3C2O)C(=O)OC(C)C4NC(=O)c5csc(n5)C(NC(=O)C6CSC(=N6)/C(=C\C)/NC(=O)C(NC(=O)c7csc(n7)C8(CCC(=NC8c9csc4n9)c%10nc(cs%10)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)C(C)(O)C(C)O)C(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J07 compound treatment 220640.0 -6260.0 -0.17 223120.0 3990.0 0.1 -0.0463 -0.2373 3189316 SPBio_002425 COc1ccc(cc1)c2ccc(=N)n(CCCC(=O)O)n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J08 compound treatment 225080.0 -1820.0 -0.05 222560.0 3430.0 0.09 0.0273 0.2738 3068727 SPBio_002426 C[S+](=N)([O-])CC[C@H](N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J09 compound treatment 258480.0 31600.0 0.84 221840.0 2710.0 0.07 0.6441 0.7623 3189317 SPBio_002427 C[C@@H]1C(=O)O[C@H]2CC34[C@H]5C[C@@H](C(C)(C)C)C46[C@@H](O)C(=O)O[C@H]6OC3(C(=O)O5)[C@@]12O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J10 compound treatment 221040.0 -5860.0 -0.16 225160.0 6030.0 0.15 -0.0021 -0.0097 737 SPBio_002428 c1nc(cs1)c2nc3ccccc3[nH]2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J11 compound treatment 223320.0 -3580.0 -0.1 205400.0 -13700.0 -0.35 -0.3144 -0.8685 716 SPBio_002429 CN(C)CCC=C1c2ccccc2C=Cc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J12 compound treatment 235760.0 8860.0 0.24 216520.0 -2610.0 -0.07 0.1201 0.4892 3189445 SPBio_002430 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4c(O)c(/C=N/N5CCN(C)CC5)c(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)c(O)c4c(O)c3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J13 compound treatment 233600.0 6700.0 0.18 226840.0 7710.0 0.2 0.2649 0.9989 1300555 SPBio_002431 CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J14 compound treatment 224120.0 -2780.0 -0.07 222840.0 3710.0 0.09 0.0142 0.1188 803 SPBio_002432 CCc1cc(ccn1)C(=S)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J15 compound treatment 229640.0 2740.0 0.07 218360.0 -774.0 -0.02 0.0378 0.4989 2080102 SPBio_002433 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J16 compound treatment 246720.0 19800.0 0.53 217360.0 -1770.0 -0.05 0.3418 0.6444 900 SPBio_002434 CN1C(=C(O)c2sccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J17 compound treatment 259560.0 32700.0 0.87 234880.0 15700.0 0.4 0.8989 0.9378 3069083 SPBio_002435 Nc1c2ccccc2nc3c(O)cccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J18 compound treatment 234680.0 7780.0 0.21 225360.0 6230.0 0.16 0.2586 0.9911 3068731 SPBio_002436 CC(=O)Oc1cc(ccc1C(=O)O)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J19 compound treatment 231400.0 4500.0 0.12 281920.0 62800.0 1.6 1.2137 0.7581 992 SPBio_002437 CC[C@H]1[C@@H](Cc2cncn2C)COC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J20 compound treatment 246880.0 20000.0 0.53 269680.0 50500.0 1.29 1.2855 0.924 4379 SPBio_002438 CN1CCCCC1CCN2c3ccccc3Sc4ccc(cc24)S(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J21 compound treatment 242800.0 15900.0 0.42 224680.0 5550.0 0.14 0.3995 0.8941 1265 SPBio_002439 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4c(Cl)cccc4Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J22 compound treatment 219200.0 -7700.0 -0.21 240840.0 21700.0 0.55 0.2451 0.4162 1470254 SPBio_002440 Cc1c(C)c2OC(C)(CCc2c(C)c1O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J23 mock treatment 223560.0 -3340.0 -0.09 229400.0 10300.0 0.26 0.1216 0.441 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 J24 mock treatment 239120.0 12200.0 0.33 202600.0 -16500.0 -0.42 -0.0669 -0.1257 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K01 mock treatment 255360.0 28500.0 0.76 175000.0 -44100.0 -1.12 -0.2569 -0.1897 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K02 mock treatment 211480.0 -15400.0 -0.41 233880.0 14700.0 0.37 -0.0256 -0.046 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K03 compound treatment 252600.0 25700.0 0.69 229960.0 10800.0 0.28 0.6792 0.9197 3068677 SPBio_002441 OC1=NC(=O)CN1/N=C/c2ccc(o2)c3ccc(cc3)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K04 compound treatment 217560.0 -9340.0 -0.25 298400.0 79300.0 2.02 1.2491 0.6151 771 SPBio_002442 CN1CCC(=C2c3ccsc3C(=O)Cc4ccccc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K05 compound treatment 270160.0 43300.0 1.15 222440.0 3310.0 0.08 0.8751 0.7566 850 SPBio_002443 Clc1cccc(c1)N2CCN(CCCn3nc4ccccn4c3=O)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K06 compound treatment 217760.0 -9140.0 -0.24 259880.0 40700.0 1.04 0.5603 0.5264 907283 SPBio_002444 NC(=N)N1CCc2ccccc2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K07 compound treatment 246880.0 20000.0 0.53 233320.0 14200.0 0.36 0.6318 0.982 936 SPBio_002445 OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K08 compound treatment 110000.0 -117000.0 -3.12 104480.0 -115000.0 -2.92 -4.2653 -0.9994 1000064 SPBio_002446 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K09 compound treatment 248280.0 21400.0 0.57 233040.0 13900.0 0.35 0.6531 0.9736 1060 SPBio_002447 CN1CCC(=C2c3ccccc3Sc4ccccc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K10 compound treatment 256360.0 29500.0 0.79 261960.0 42800.0 1.09 1.3254 0.9872 3189193 SPBio_002448 CC[C@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K11 compound treatment 228040.0 1140.0 0.03 229120.0 9990.0 0.25 0.2011 0.7862 1069 SPBio_002449 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K12 compound treatment 174560.0 -52300.0 -1.4 218840.0 -294.0 -0.01 -0.992 -0.7109 1496 SPBio_002450 CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K13 compound treatment 293240.0 66300.0 1.77 226760.0 7630.0 0.19 1.3879 0.7799 1113 SPBio_002451 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(=O)O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K14 compound treatment 206520.0 -20400.0 -0.54 364160.0 145000.0 3.69 2.2233 0.5965 3068886 SPBio_002452 CC(C)/N=c/1\cc2n(c3ccc(Cl)cc3)c4ccccc4nc2cc1Nc5ccc(Cl)cc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K15 compound treatment 155680.0 -71200.0 -1.9 127320.0 -91800.0 -2.33 -2.9935 -0.9947 3068682 SPBio_002453 CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K16 compound treatment 237760.0 10900.0 0.29 228640.0 9510.0 0.24 0.3757 0.996 975 SPBio_002454 CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K17 compound treatment 221440.0 -5460.0 -0.15 209400.0 -9730.0 -0.25 -0.2779 -0.968 1348 SPBio_002455 Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K18 compound treatment 286400.0 59500.0 1.59 246200.0 27100.0 0.69 1.6084 0.9301 1000105 SPBio_002456 CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K19 compound treatment 176160.0 -50700.0 -1.35 169440.0 -49700.0 -1.26 -1.8501 -0.9994 3055129 SPBio_002457 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@@]21C)c5ccc(cc5)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K20 compound treatment 235240.0 8340.0 0.22 237120.0 18000.0 0.46 0.4806 0.9451 1000143 SPBio_002458 NC(Cn1ccc(=O)c(O)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K21 compound treatment 230000.0 3100.0 0.08 227040.0 7910.0 0.2 0.2006 0.9229 1045066 SPBio_002459 O=C(Nc1ccccc1)OCC(CN2CCCCC2)OC(=O)Nc3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K22 compound treatment 213080.0 -13800.0 -0.37 259680.0 40500.0 1.03 0.4685 0.4279 2777 SPBio_002460 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K23 mock treatment 209080.0 -17800.0 -0.48 215120.0 -4010.0 -0.1 -0.4081 -0.8398 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 K24 mock treatment 226200.0 -699.0 -0.02 202320.0 -16800.0 -0.43 -0.3155 -0.7372 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L01 mock treatment 253760.0 26900.0 0.72 211200.0 -7930.0 -0.2 0.3638 0.4889 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L02 mock treatment 276920.0 50000.0 1.33 233560.0 14400.0 0.37 1.2024 0.8693 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L03 compound treatment 215360.0 -11500.0 -0.31 234760.0 15600.0 0.4 0.0634 0.1262 1055159 SPBio_002461 NC(CC(=O)c1cccc(O)c1N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L04 compound treatment 256920.0 30000.0 0.8 199120.0 -20000.0 -0.51 0.2062 0.2173 907463 SPBio_002462 Cc1nc2ccccn2c(=O)c1CCN3CCC(CC3)C(=O)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L05 compound treatment 222200.0 -4700.0 -0.13 242800.0 23700.0 0.6 0.3369 0.5481 3189433 SPBio_002463 OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L06 compound treatment 271920.0 45000.0 1.2 205960.0 -13200.0 -0.33 0.6119 0.491 1024517 SPBio_002464 COc1cc2CCNC(C)c2cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L07 compound treatment 261520.0 34600.0 0.92 216720.0 -2410.0 -0.06 0.6093 0.6586 3069088 SPBio_002465 COC1=C[C@@H]2[C@@H](C3=C2c4c(OC)c(OC)c(OC)cc4CC[C@@H]3NC(=O)C)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L08 compound treatment 305320.0 78400.0 2.09 251640.0 32500.0 0.83 2.0629 0.9175 1193 SPBio_002466 CCOc1ccc(NC(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L09 compound treatment 240400.0 13500.0 0.36 228880.0 9750.0 0.25 0.4298 0.9834 1134 SPBio_002467 CN1C[C@H](CO)C=C2[C@H]1Cc3c[nH]c4cccc2c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L10 compound treatment 69800.0 -157000.0 -4.19 54920.0 -164000.0 -4.18 -5.9143 -1.0 3474094 SPBio_002468 OC1=C(C2CCC(CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L11 compound treatment 238760.0 11900.0 0.32 297960.0 78800.0 2.0 1.6409 0.8087 3174101 SPBio_002469 CN1CCc2c(C1)c3ccccc3n2Cc4ccccc4.OS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L12 compound treatment 255360.0 28500.0 0.76 248960.0 29800.0 0.76 1.0728 1.0 3058468 SPBio_002470 COc1ccc(OC)c(c1)C(O)C(C)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L13 compound treatment 301240.0 74300.0 1.98 249800.0 30700.0 0.78 1.9529 0.9169 3174345 SPBio_002471 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N.OC(=O)c1cc(ccc1O)S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L14 compound treatment 272000.0 45100.0 1.2 229920.0 10800.0 0.27 1.0442 0.8466 1001858 SPBio_002472 CC(C)NC[C@H](O)COc1ccc(CC(=O)N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L15 compound treatment 99600.0 -127000.0 -3.39 88240.0 -131000.0 -3.33 -4.7534 -1.0 1035 SPBio_002473 Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L16 compound treatment 238560.0 11700.0 0.31 217880.0 -1250.0 -0.03 0.1973 0.6313 904 SPBio_002474 NC(=O)CN1CCCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L17 compound treatment 258560.0 31700.0 0.84 253520.0 34400.0 0.87 1.2151 0.9998 988 SPBio_002475 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L18 compound treatment 213640.0 -13300.0 -0.35 192440.0 -26700.0 -0.68 -0.7299 -0.9538 948 SPBio_002476 O=C1C(C(=O)c2ccccc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L19 compound treatment 18800.0 -208000.0 -5.55 16920.0 -202000.0 -5.14 -7.559 -0.9993 449 SPBio_002477 CC1=CC(=O)c2ccccc2C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L20 compound treatment 268800.0 41900.0 1.12 229520.0 10400.0 0.26 0.9767 0.8508 3189446 SPBio_002478 COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc3CCC(NC(=O)C)c4cc(=O)c(SC)ccc4-c3c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L21 compound treatment 254680.0 27800.0 0.74 218280.0 -854.0 -0.02 0.5084 0.6861 3069122 SPBio_002479 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O.COC(N)(CO)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L22 compound treatment 242440.0 15500.0 0.41 211120.0 -8010.0 -0.2 0.1489 0.3225 3068774 SPBio_002480 Nc1cc(C(=C(Cl)Cl)Cl)c(cc1S(=O)(=O)N)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L23 mock treatment 217120.0 -9780.0 -0.26 220520.0 1390.0 0.04 -0.1594 -0.606 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 L24 mock treatment 267600.0 40700.0 1.09 200640.0 -18500.0 -0.47 0.4348 0.3677 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M01 mock treatment 254400.0 27500.0 0.73 209840.0 -9290.0 -0.24 0.3514 0.4561 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M02 mock treatment 224600.0 -2300.0 -0.06 211800.0 -7330.0 -0.19 -0.1752 -0.8926 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M03 compound treatment 206400.0 -20500.0 -0.55 207000.0 -12100.0 -0.31 -0.6046 -0.9634 1608 SPBio_002481 NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M04 compound treatment 50240.0 -177000.0 -4.71 85360.0 -134000.0 -3.4 -5.7358 -0.9872 907366 SPBio_002482 Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M05 compound treatment 189040.0 -37900.0 -1.01 187520.0 -31600.0 -0.8 -1.2822 -0.9936 3068878 SPBio_002483 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M06 compound treatment 208720.0 -18200.0 -0.48 203440.0 -15700.0 -0.4 -0.6249 -0.9953 3480396 SPBio_002484 CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M07 compound treatment 257000.0 30100.0 0.8 213080.0 -6050.0 -0.15 0.4587 0.5613 907526 SPBio_002485 CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc4ccccc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M08 compound treatment 194560.0 -32300.0 -0.86 166240.0 -52900.0 -1.34 -1.5607 -0.9769 86 SPBio_002486 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCN(C)Cc3ccccc3)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M09 compound treatment 20800.0 -206000.0 -5.5 17800.0 -201000.0 -5.12 -7.5055 -0.9994 773 SPBio_002487 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M10 compound treatment 228480.0 1580.0 0.04 212080.0 -7050.0 -0.18 -0.097 -0.5266 1210 SPBio_002488 CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M11 compound treatment 231040.0 4140.0 0.11 214160.0 -4970.0 -0.13 -0.0114 -0.0677 1357 SPBio_002489 CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M12 compound treatment 40760.0 -186000.0 -4.96 55760.0 -163000.0 -4.15 -6.4467 -0.9961 1135 SPBio_002490 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M13 compound treatment 231080.0 4180.0 0.11 210160.0 -8970.0 -0.23 -0.0825 -0.3249 927 SPBio_002491 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M14 compound treatment 25920.0 -201000.0 -5.36 23400.0 -196000.0 -4.98 -7.3083 -0.9993 907273 SPBio_002492 Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M15 compound treatment 247840.0 20900.0 0.56 212120.0 -7010.0 -0.18 0.2687 0.4584 876 SPBio_002493 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M16 compound treatment 194640.0 -32300.0 -0.86 177920.0 -41200.0 -1.05 -1.3492 -0.9952 990 SPBio_002494 CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M17 compound treatment 29240.0 -198000.0 -5.27 23400.0 -196000.0 -4.98 -7.2457 -0.9996 2117626 SPBio_002495 Fc1ccc(cc1)C(CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34)c5ccc(F)cc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M18 compound treatment 109600.0 -117000.0 -3.13 78520.0 -141000.0 -3.58 -4.7396 -0.9978 1351 SPBio_002496 Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M19 compound treatment 204040.0 -22900.0 -0.61 201120.0 -18000.0 -0.46 -0.7548 -0.9901 467359 SPBio_002497 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M20 compound treatment 179440.0 -47500.0 -1.27 110080.0 -109000.0 -2.77 -2.8555 -0.9369 3060108 SPBio_002498 CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M21 compound treatment 213400.0 -13500.0 -0.36 194680.0 -24500.0 -0.62 -0.6942 -0.9662 714 SPBio_002499 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc2ccc(OC)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M22 compound treatment 201760.0 -25100.0 -0.67 217800.0 -1330.0 -0.03 -0.4979 -0.7419 1000211 SPBio_002500 C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@H]2[C@H](O)C[C@H]4/C(=C(\CCC=C(C)C)/C(=O)O)/[C@H](C[C@@]43C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M23 mock treatment 214480.0 -12400.0 -0.33 212120.0 -7010.0 -0.18 -0.3602 -0.9579 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 M24 mock treatment 231360.0 4460.0 0.12 201880.0 -17300.0 -0.44 -0.2261 -0.4974 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N01 mock treatment 244800.0 17900.0 0.48 210840.0 -8290.0 -0.21 0.1884 0.361 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N02 mock treatment 238600.0 11700.0 0.31 208240.0 -10900.0 -0.28 0.0247 0.0593 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N03 compound treatment 207640.0 -19300.0 -0.51 185600.0 -33500.0 -0.85 -0.966 -0.9705 2830 SPBio_002501 Clc1ccc2n(C3CCN(CCCn4c(=O)[nH]c5ccccc45)CC3)c(=O)[nH]c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N04 compound treatment 15760.0 -211000.0 -5.63 14160.0 -205000.0 -5.21 -7.6659 -0.9993 1309 SPBio_002502 Cc1cc(C2CCCCC2)n(O)c(=O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N05 compound treatment 200800.0 -26100.0 -0.7 218280.0 -854.0 -0.02 -0.5074 -0.7288 3189434 SPBio_002503 Nc1nc(cs1)/C(=N\OCC(=O)O)/C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N06 compound treatment 199960.0 -26900.0 -0.72 222880.0 3750.0 0.1 -0.4405 -0.608 722 SPBio_002504 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N07 compound treatment 217080.0 -9820.0 -0.26 203760.0 -15400.0 -0.39 -0.4615 -0.981 3069124 SPBio_002505 CN(C(=O)C)c1c(I)c(NC(=O)C)c(I)c(C(=O)NC2[C@H](O)OC(CO)[C@@H](O)[C@H]2O)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N08 compound treatment 214640.0 -12300.0 -0.33 201640.0 -17500.0 -0.44 -0.5457 -0.9885 1213 SPBio_002506 CNCCc1ccccn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N09 compound treatment 218200.0 -8700.0 -0.23 211600.0 -7530.0 -0.19 -0.2995 -0.9955 3189435 SPBio_002507 C[C@@H](O[C@@H]1[C@H](O)C(CO)O[C@H](O)C1NC(=O)C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N10 compound treatment 214920.0 -12000.0 -0.32 203160.0 -16000.0 -0.41 -0.513 -0.9929 1000177 SPBio_002508 NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N11 compound treatment 224280.0 -2620.0 -0.07 203800.0 -15300.0 -0.39 -0.3251 -0.8207 2181 SPBio_002509 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3cc(O)c(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N12 compound treatment 227480.0 581.0 0.02 209960.0 -9170.0 -0.23 -0.154 -0.6587 1000096 SPBio_002510 C1CN2CC(N=C2S1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N13 compound treatment 232160.0 5260.0 0.14 220520.0 1390.0 0.04 0.1241 0.8581 1733214 SPBio_002511 Oc1ccc(cc1)C2CC(=O)c3c(O)cc(O)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N14 compound treatment 228280.0 1380.0 0.04 200960.0 -18200.0 -0.46 -0.3007 -0.6487 3068775 SPBio_002512 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N15 compound treatment 216200.0 -10700.0 -0.29 202560.0 -16600.0 -0.42 -0.4997 -0.9819 895 SPBio_002513 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N16 compound treatment 221080.0 -5820.0 -0.16 205080.0 -14100.0 -0.36 -0.3624 -0.9302 1214 SPBio_002514 CCOC(=O)Nc1c[n+](no1)N2CCOCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N17 compound treatment 213480.0 -13400.0 -0.36 206320.0 -12800.0 -0.33 -0.4834 -0.9989 822 SPBio_002515 CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N18 compound treatment 225080.0 -1820.0 -0.05 194320.0 -24800.0 -0.63 -0.4804 -0.7592 1000114 SPBio_002516 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N19 compound treatment 232000.0 5100.0 0.14 207440.0 -11700.0 -0.3 -0.1141 -0.3489 1067495 SPBio_002517 [O-][N+](=O)c1cnc(s1)N2CCNC2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N20 compound treatment 221640.0 -5260.0 -0.14 189720.0 -29400.0 -0.75 -0.628 -0.8253 1365793 SPBio_002518 COc1ccc(CN2CCNCC2)c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N21 compound treatment 217920.0 -8980.0 -0.24 215960.0 -3170.0 -0.08 -0.2264 -0.8959 3069161 SPBio_002519 NCc1ccccc1CC(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N22 compound treatment 17240.0 -210000.0 -5.59 14600.0 -205000.0 -5.2 -7.6301 -0.9993 3103826 SPBio_002520 C/C/1=C\CC[C@@]2(C)O[C@@H]2[C@H]3OC(=O)C(=C)[C@@H]3CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N23 mock treatment 240520.0 13600.0 0.36 216520.0 -2610.0 -0.07 0.2098 0.5683 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 N24 mock treatment 237040.0 10100.0 0.27 204240.0 -14900.0 -0.38 -0.0766 -0.1646 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O01 mock treatment 229640.0 2740.0 0.07 243160.0 24000.0 0.61 0.4836 0.7861 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O02 mock treatment 217280.0 -9620.0 -0.26 226120.0 6990.0 0.18 -0.0557 -0.1787 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O03 compound treatment 167720.0 -59200.0 -1.58 184320.0 -34800.0 -0.89 -1.7416 -0.9627 3177204 SPBio_002521 CC(C(O)c1ccc(O)cc1)N2CCC(Cc3ccccc3)CC2.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O04 compound treatment 239800.0 12900.0 0.34 227680.0 8550.0 0.22 0.3969 0.9755 743 SPBio_002522 CC(C)(C)NCC(O)c1cc(O)cc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O05 compound treatment 216240.0 -10700.0 -0.28 116400.0 -103000.0 -2.61 -2.048 -0.7794 43 SPBio_002523 Fc1ccc(cc1)C(N2CCN(C/C=C/c3ccccc3)CC2)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O06 compound treatment 219520.0 -7380.0 -0.2 200720.0 -18400.0 -0.47 -0.4702 -0.9258 3061431 SPBio_002524 OC(C(O)C(=O)O)C(=O)O.Fc1ccc(cc1)C(=O)C2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O07 compound treatment 41720.0 -185000.0 -4.94 71040.0 -148000.0 -3.77 -6.1539 -0.9911 437 SPBio_002525 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O08 compound treatment 243640.0 16700.0 0.45 187320.0 -31800.0 -0.81 -0.2564 -0.2775 907335 SPBio_002526 C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)c3ccc(cc3)C4(O)C[N+](C)(C)CCO4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O09 compound treatment 247840.0 20900.0 0.56 193800.0 -25300.0 -0.64 -0.0607 -0.0712 3189181 SPBio_002527 CCOC(=O)[C@@H](CCc1ccccc1)NC(C)C(=O)N2CCC[C@@H]2C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O10 compound treatment 241240.0 14300.0 0.38 220680.0 1550.0 0.04 0.2982 0.7757 3471415 SPBio_002528 NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(O)C(O)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O11 compound treatment 221760.0 -5140.0 -0.14 241560.0 22400.0 0.57 0.3063 0.5223 1077 SPBio_002529 CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O12 compound treatment 254600.0 27700.0 0.74 216800.0 -2330.0 -0.06 0.4803 0.6482 3068923 SPBio_002530 NCC[C@H](O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC3OC(CO)C(O)C(N)C3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O13 compound treatment 261840.0 34900.0 0.93 222440.0 3310.0 0.08 0.7182 0.7678 74 SPBio_002531 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O14 compound treatment 101640.0 -125000.0 -3.34 103440.0 -116000.0 -2.94 -4.4416 -0.998 3189304 SPBio_002532 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O15 compound treatment 234480.0 7580.0 0.2 202760.0 -16400.0 -0.42 -0.1515 -0.3273 3055 SPBio_002533 NC(=N)NCCN1CCCCCCC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O16 compound treatment 17920.0 -209000.0 -5.57 13760.0 -205000.0 -5.22 -7.6324 -0.9995 3068926 SPBio_002534 CCN(CC)CCOc1ccc(cc1)/C(=C(/Cl)\c2ccccc2)/c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O17 compound treatment 124400.0 -102000.0 -2.73 108760.0 -110000.0 -2.81 -3.9169 -0.9999 763 SPBio_002535 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O18 compound treatment 252120.0 25200.0 0.67 183160.0 -36000.0 -0.91 -0.1713 -0.1509 3189305 SPBio_002536 CN1CCCN=C1/C=C/c2cccc(O)c2.OC(=O)c1cc2ccccc2c(Cc3cc4ccccc4c(C(=O)O)c3O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O19 compound treatment 142080.0 -84800.0 -2.26 85000.0 -134000.0 -3.41 -4.0107 -0.9801 907228 SPBio_002537 CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O20 compound treatment 175480.0 -51400.0 -1.37 98080.0 -121000.0 -3.08 -3.1459 -0.9336 1041 SPBio_002538 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O21 compound treatment 164160.0 -62700.0 -1.67 80720.0 -138000.0 -3.52 -3.6714 -0.9422 1130 SPBio_002539 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O22 compound treatment 242440.0 15500.0 0.41 233240.0 14100.0 0.36 0.5466 0.9974 3189306 SPBio_002540 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4OC(CO[C@@H]5OC(C)[C@H](O)[C@H](O)C5O)[C@@H](O)[C@@H](O)C4O)cc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O23 mock treatment 268240.0 41300.0 1.1 243200.0 24100.0 0.61 1.2121 0.9614 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 O24 mock treatment 267080.0 40200.0 1.07 210000.0 -9130.0 -0.23 0.5933 0.5412 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P01 mock treatment 189600.0 -37300.0 -0.99 220200.0 1070.0 0.03 -0.684 -0.6876 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P02 mock treatment 330120.0 103000.0 2.75 212120.0 -7010.0 -0.18 1.8199 0.6599 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P03 compound treatment 18400.0 -208000.0 -5.56 13040.0 -206000.0 -5.24 -7.6363 -0.9996 1000325 SPBio_002541 C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P04 compound treatment 242240.0 15300.0 0.41 145640.0 -73500.0 -1.87 -1.0321 -0.5396 922 SPBio_002542 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P05 compound treatment 237400.0 10500.0 0.28 178240.0 -40900.0 -1.04 -0.5373 -0.4989 3069162 SPBio_002543 CC(C)(CO)[C@H](O)C(=O)NCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P06 compound treatment 222360.0 -4540.0 -0.12 183920.0 -35200.0 -0.9 -0.7187 -0.7954 2284 SPBio_002544 C[C@H](Cc1ccccc1)N(C)CC#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P07 compound treatment 271600.0 44700.0 1.19 168720.0 -50400.0 -1.28 -0.0636 -0.0364 3189436 SPBio_002545 CO[C@]1(NC(=O)C2SC(=C(C(=O)N)C(=O)O)S2)[C@H]3SCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P08 compound treatment 241000.0 14100.0 0.38 91800.0 -127000.0 -3.24 -2.0235 -0.6208 1020 SPBio_002546 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P09 compound treatment 262680.0 35800.0 0.95 140720.0 -78400.0 -1.99 -0.7352 -0.3326 1534 SPBio_002547 O=C(/C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P10 compound treatment 236280.0 9380.0 0.25 199160.0 -20000.0 -0.51 -0.1823 -0.3219 196 SPBio_002548 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P11 compound treatment 235080.0 8180.0 0.22 200000.0 -19100.0 -0.49 -0.1898 -0.3559 1537011 SPBio_002549 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P12 compound treatment 103880.0 -123000.0 -3.28 67840.0 -151000.0 -3.85 -5.0395 -0.9969 1931603 SPBio_002550 Oc1ccc(cc1)C(=O)N/N=C/c2ccc(o2)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P13 compound treatment 12320.0 -215000.0 -5.72 9360.0 -210000.0 -5.33 -7.8171 -0.9994 2551 SPBio_002551 COc1cc(NC(C)CCCN)c2ncccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P14 compound treatment 83280.0 -144000.0 -3.83 83680.0 -135000.0 -3.44 -5.1431 -0.9986 804 SPBio_002552 COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P15 compound treatment 251240.0 24300.0 0.65 136320.0 -82800.0 -2.11 -1.03 -0.4675 1072 SPBio_002553 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P16 compound treatment 274560.0 47700.0 1.27 178200.0 -40900.0 -1.04 0.1626 0.099 3189565 SPBio_002554 CC[C@@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@@H](C)[C@@H]4N[C@H](COCCOC)OC([C@H]4C)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P17 compound treatment 76240.0 -151000.0 -4.02 29560.0 -190000.0 -4.82 -6.2488 -0.9959 3480329 SPBio_002555 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(Cl)c2Cl)C(=O)OC)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P18 compound treatment 293400.0 66500.0 1.77 176240.0 -42900.0 -1.09 0.4826 0.2318 3474312 SPBio_002556 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P19 compound treatment 267280.0 40400.0 1.08 195640.0 -23500.0 -0.6 0.3389 0.2752 1362 SPBio_002557 COc1c2occc2cc3ccc(=O)oc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P20 compound treatment 241680.0 14800.0 0.39 152240.0 -66900.0 -1.7 -0.924 -0.5292 3060137 SPBio_002558 COc1ccccc1N2CCN(CCCCNC(=O)c3ccc4ccccc4c3)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P21 compound treatment 10920.0 -216000.0 -5.76 7040.0 -212000.0 -5.39 -7.8852 -0.9995 3189437 SPBio_002559 COc1ccc(CC(N)C(=O)N[C@@H]2C(O)[C@@H](O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P22 compound treatment 161440.0 -65500.0 -1.75 71160.0 -148000.0 -3.76 -3.8946 -0.939 1137095 SPBio_002560 CC(Cc1ccccc1)NCCC(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P23 mock treatment 250320.0 23400.0 0.62 232280.0 13100.0 0.33 0.6779 0.9571 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2165 P24 mock treatment 230760.0 3860.0 0.1 188000.0 -31100.0 -0.79 -0.487 -0.61 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A01 mock treatment 240120.0 16200.0 0.43 224200.0 7650.0 0.19 0.4433 0.9348 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A02 mock treatment 214600.0 -9300.0 -0.25 242200.0 25600.0 0.65 0.2858 0.4097 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A03 compound treatment 220640.0 -3260.0 -0.09 260720.0 44200.0 1.12 0.7326 0.6505 3189566 SPBio_002561 COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7cccc(Oc(c1O)c32)c7)N(C)CCc6cc5OC)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A04 compound treatment 223120.0 -778.0 -0.02 244720.0 28200.0 0.72 0.4917 0.6863 3187611 SPBio_002562 COc1cc(ccc1c2nc3ncccc3[nH]2)S(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A05 compound treatment 222240.0 -1660.0 -0.04 252920.0 36400.0 0.92 0.6226 0.6725 907285 SPBio_002563 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@H]3[C@@H](Cc4c[nH]c5cccc3c45)N(C)C2)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A06 compound treatment 212160.0 -11700.0 -0.31 275920.0 59400.0 1.51 0.846 0.5488 1254 SPBio_002564 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A07 compound treatment 180880.0 -43000.0 -1.15 233600.0 17000.0 0.43 -0.5046 -0.4115 961 SPBio_002565 COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A08 compound treatment 209200.0 -14700.0 -0.39 258360.0 41800.0 1.06 0.4745 0.4189 3187612 SPBio_002566 CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A09 compound treatment 174280.0 -49600.0 -1.32 246280.0 29700.0 0.76 -0.401 -0.2632 3487467 SPBio_002567 CCOC(=O)Oc1c(OC)cc(cc1OC)C(=O)OC2CC3CN4CCc5c([nH]c6cc(OC)ccc56)C4CC3C(C2OC)C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A10 compound treatment 210320.0 -13600.0 -0.36 251080.0 34500.0 0.88 0.3648 0.3841 3069530 SPBio_002568 CC(=O)NC1CCSC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A11 compound treatment 212760.0 -11100.0 -0.3 240840.0 24300.0 0.62 0.2266 0.3308 1000124 SPBio_002569 CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A12 compound treatment 242360.0 18500.0 0.49 245800.0 29200.0 0.74 0.8739 0.9799 1000240 SPBio_002570 CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A13 compound treatment 224320.0 422.0 0.01 212760.0 -3790.0 -0.1 -0.0603 -0.6205 976 SPBio_002571 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A14 compound treatment 32000.0 -192000.0 -5.12 46920.0 -170000.0 -4.31 -6.6678 -0.9964 3187613 SPBio_002572 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)OC2CC[C@]3(C=O)[C@H]4CC[C@]5(C)[C@H](CC[C@@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A15 compound treatment 229000.0 5100.0 0.14 248200.0 31600.0 0.8 0.6652 0.8151 3189567 SPBio_002573 CCN1C[C@@]2(COC)C3[C@@H](OC)[C@H]4[C@@H]1[C@@]3(C5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)C5[C@]4(OC(=O)C)[C@@H](O)[C@H]6OC)[C@H](C[C@H]2O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A16 compound treatment 221040.0 -2860.0 -0.08 250680.0 34100.0 0.87 0.5597 0.6425 2060360 SPBio_002574 C1CN=C(C1)c2cccnc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A17 compound treatment 187040.0 -36900.0 -0.98 229760.0 13200.0 0.34 -0.4575 -0.4405 3141 SPBio_002575 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)/C=C/c6cc(OC)c(OC)c(OC)c6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A18 compound treatment 210040.0 -13900.0 -0.37 242880.0 26300.0 0.67 0.212 0.2773 3069532 SPBio_002576 C[N+]1(C)C[C@@H](O)C[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A19 compound treatment 212280.0 -11600.0 -0.31 237200.0 20600.0 0.52 0.1522 0.2496 3068781 SPBio_002577 CC(C)[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](Cc5c[nH]c6cccc4c56)N(C)C3)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A20 compound treatment 218680.0 -5220.0 -0.14 253640.0 37100.0 0.94 0.5684 0.5963 946 SPBio_002578 OCCNC(=O)Cn1ccnc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A21 compound treatment 31160.0 -193000.0 -5.14 40800.0 -176000.0 -4.47 -6.7937 -0.9976 3189569 SPBio_002579 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1CC4NCCc5cc(OC)c(OC)cc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A22 compound treatment 215720.0 -8180.0 -0.22 244240.0 27700.0 0.7 0.3436 0.4662 3187614 SPBio_002580 NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)[C@H](O)[C@@H]2N)[C@H](OC3O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A23 mock treatment 235040.0 11100.0 0.3 230240.0 13700.0 0.35 0.4561 0.9969 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 A24 mock treatment 228120.0 4220.0 0.11 223480.0 6930.0 0.18 0.2041 0.9766 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B01 mock treatment 247080.0 23200.0 0.62 266600.0 50000.0 1.27 1.3368 0.945 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B02 mock treatment 224520.0 622.0 0.02 240760.0 24200.0 0.62 0.4469 0.7259 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B03 compound treatment 197920.0 -26000.0 -0.69 224440.0 7890.0 0.2 -0.348 -0.4826 1606 SPBio_002581 NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B04 compound treatment 229040.0 5140.0 0.14 244760.0 28200.0 0.72 0.6041 0.8273 1412 SPBio_002582 CN(C)CCOC(c1ccc(Cl)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B05 compound treatment 199080.0 -24800.0 -0.66 257440.0 40900.0 1.04 0.2672 0.2168 1524 SPBio_002583 CC(C)Nc1c(C)n(C)n(c2ccccc2)c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B06 compound treatment 203160.0 -20700.0 -0.55 246880.0 30300.0 0.77 0.1542 0.1626 3069629 SPBio_002584 CC(=O)/N=c/1\sc(nn1C)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B07 compound treatment 207160.0 -16700.0 -0.45 221520.0 4970.0 0.13 -0.2263 -0.4879 883 SPBio_002585 CC(Oc1ccccc1)C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B08 compound treatment 193760.0 -30100.0 -0.8 213800.0 -2750.0 -0.07 -0.6177 -0.7658 818 SPBio_002586 CCC1(CC)C(=O)NC=CC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B09 compound treatment 192640.0 -31300.0 -0.83 225640.0 9090.0 0.23 -0.426 -0.4925 887 SPBio_002587 COc1ccc(NS(=O)(=O)c2ccc(N)cc2)nn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B10 compound treatment 202080.0 -21800.0 -0.58 231760.0 15200.0 0.39 -0.138 -0.1975 795 SPBio_002588 CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B11 compound treatment 177880.0 -46000.0 -1.23 172560.0 -44000.0 -1.12 -1.6586 -0.9989 745 SPBio_002589 CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B12 compound treatment 225720.0 1820.0 0.05 249520.0 33000.0 0.84 0.627 0.7468 1129 SPBio_002590 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B13 compound treatment 218920.0 -4980.0 -0.13 245920.0 29400.0 0.75 0.4341 0.5724 3263 SPBio_002591 CNC(C)(C)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B14 compound treatment 229280.0 5380.0 0.14 224840.0 8290.0 0.21 0.2504 0.9825 755 SPBio_002592 CC(CN(C)C)CN1c2ccccc2CCc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B15 compound treatment 198800.0 -25100.0 -0.67 244920.0 28400.0 0.72 0.0368 0.0374 3187750 SPBio_002593 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B16 compound treatment 102040.0 -122000.0 -3.25 180400.0 -36200.0 -0.92 -2.9475 -0.8729 1088922 SPBio_002594 CN(C)CCN(Cc1ccc(Cl)cc1)c2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B17 compound treatment 211640.0 -12300.0 -0.33 233800.0 17200.0 0.44 0.079 0.1444 751 SPBio_002595 COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B18 compound treatment 215360.0 -8540.0 -0.23 228800.0 12200.0 0.31 0.0592 0.1535 3043753 SPBio_002596 [O-][N+](=O)c1ccc(/C=N/N2CCOC2=O)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B19 compound treatment 231400.0 7500.0 0.2 236640.0 20100.0 0.51 0.5026 0.9163 1146 SPBio_002597 Nc1ccc(cc1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B20 compound treatment 209280.0 -14600.0 -0.39 237840.0 21300.0 0.54 0.1071 0.1606 2570 SPBio_002598 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B21 compound treatment 211520.0 -12400.0 -0.33 231880.0 15300.0 0.39 0.0422 0.0826 3069577 SPBio_002599 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC(=O)[C@]23C)OC61CCC(C)CO6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B22 compound treatment 12640.0 -211000.0 -5.63 12800.0 -204000.0 -5.18 -7.6463 -0.9991 871 SPBio_002600 Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B23 mock treatment 219240.0 -4660.0 -0.12 239600.0 23000.0 0.59 0.3265 0.5451 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 B24 mock treatment 234280.0 10400.0 0.28 233600.0 17000.0 0.43 0.5022 0.9765 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C01 mock treatment 214280.0 -9620.0 -0.26 234920.0 18400.0 0.47 0.1489 0.2794 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C02 mock treatment 223320.0 -578.0 -0.02 223520.0 6970.0 0.18 0.1143 0.6431 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C03 compound treatment 147920.0 -76000.0 -2.03 176360.0 -40200.0 -1.02 -2.1551 -0.9498 1218 SPBio_002601 CCCCNc1ccc(cc1)C(=O)OCCN(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C04 compound treatment 200040.0 -23900.0 -0.64 233000.0 16400.0 0.42 -0.1541 -0.2025 1624 SPBio_002602 CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C05 compound treatment 128880.0 -95000.0 -2.53 215440.0 -1110.0 -0.03 -1.8114 -0.715 1000293 SPBio_002603 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C06 compound treatment 197440.0 -26500.0 -0.71 235320.0 18800.0 0.48 -0.1614 -0.1895 3187615 SPBio_002604 CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)OC2[C@@]53C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C07 compound treatment 216600.0 -7300.0 -0.19 200920.0 -15600.0 -0.4 -0.4187 -0.946 3189571 SPBio_002605 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]61CCC(C)CN6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C08 compound treatment 197240.0 -26700.0 -0.71 219200.0 2650.0 0.07 -0.455 -0.6373 1244 SPBio_002606 C[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C09 compound treatment 224680.0 782.0 0.02 246760.0 30200.0 0.77 0.5578 0.726 964 SPBio_002607 CN(C)N=Nc1[nH]cnc1C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C10 compound treatment 203680.0 -20200.0 -0.54 218280.0 1730.0 0.04 -0.3502 -0.6474 3187616 SPBio_002608 C/C(=C(\CCOP(=O)(O)O)/SC(=O)c1ccccc1)/N(Cc2cnc(C)nc2N)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C11 compound treatment 200720.0 -23200.0 -0.62 224160.0 7610.0 0.19 -0.3002 -0.4637 3471597 SPBio_002609 CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C12 compound treatment 209040.0 -14900.0 -0.4 228040.0 11500.0 0.29 -0.0736 -0.1496 3069534 SPBio_002610 CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C13 compound treatment 224720.0 822.0 0.02 236920.0 20400.0 0.52 0.3817 0.7364 1092107 SPBio_002611 CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C14 compound treatment 28400.0 -195000.0 -5.21 39040.0 -178000.0 -4.51 -6.8774 -0.9974 3187617 SPBio_002612 CC1OC(C[C@@H](O)[C@@H]1OC2C[C@@H](O)[C@H](OC3C[C@@H](OC(=O)C)[C@H](OC4OC(CO)[C@@H](O)[C@@H](O)[C@@H]4O)C(C)O3)C(C)O2)OC5CC[C@@]6(C)[C@H](CC[C@@]7(C)[C@@]8(O)CC[C@H](C9=CC(=O)OC9)[C@@]8(C)[C@H](O)C[C@]67C)C5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C15 compound treatment 201320.0 -22600.0 -0.6 216240.0 -314.0 -0.01 -0.4313 -0.7164 1000115 SPBio_002613 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C16 compound treatment 196800.0 -27100.0 -0.72 211600.0 -4950.0 -0.13 -0.6 -0.818 3103678 SPBio_002614 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)/NCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C17 compound treatment 197520.0 -26400.0 -0.7 216320.0 -234.0 -0.01 -0.5015 -0.7131 450 SPBio_002615 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C18 compound treatment 203920.0 -20000.0 -0.53 231320.0 14800.0 0.38 -0.1112 -0.1706 827 SPBio_002616 CCCCC1(COC(=O)CCC(=O)O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C19 compound treatment 209880.0 -14000.0 -0.37 263120.0 46600.0 1.18 0.5729 0.4614 1084508 SPBio_002617 COc1ccc2cc3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C20 compound treatment 203800.0 -20100.0 -0.54 236240.0 19700.0 0.5 -0.025 -0.0341 3069535 SPBio_002618 C(Nc1ncnc2nc[nH]c12)c3ccco3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C21 compound treatment 203720.0 -20200.0 -0.54 221400.0 4850.0 0.12 -0.2933 -0.5314 1219467 SPBio_002619 COc1cc2CCC(N)c3cc(=O)c(O)ccc3-c2c(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C22 compound treatment 61440.0 -162000.0 -4.33 71680.0 -145000.0 -3.68 -5.6676 -0.9967 3187618 SPBio_002620 CC[C@H](C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C/C=C(\C)/C(O[C@H]4C[C@H](OC)C(O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2)C=C[C@@H]1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C23 mock treatment 199280.0 -24600.0 -0.66 226520.0 9970.0 0.25 -0.285 -0.405 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 C24 mock treatment 212640.0 -11300.0 -0.3 201880.0 -14700.0 -0.37 -0.4761 -0.9942 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D01 mock treatment 216680.0 -7220.0 -0.19 238960.0 22400.0 0.57 0.2667 0.4436 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D02 mock treatment 208560.0 -15300.0 -0.41 226880.0 10300.0 0.26 -0.1035 -0.213 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D03 compound treatment 213400.0 -10500.0 -0.28 216680.0 126.0 0.0 -0.1957 -0.699 706 SPBio_002621 Nc1ccc(cc1)S(=O)(=O)Nc2cnc3ccccc3n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D04 compound treatment 214920.0 -8980.0 -0.24 234560.0 18000.0 0.46 0.1545 0.299 3472295 SPBio_002622 COc1c(O)cc2C(=O)OC3C(O)C(O)C(CO)OC3c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D05 compound treatment 211680.0 -12200.0 -0.33 226920.0 10400.0 0.26 -0.044 -0.105 3187751 SPBio_002623 CN(N=O)C(=O)NC1[C@@H](O)OC(CO)[C@@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D06 compound treatment 216280.0 -7620.0 -0.2 229400.0 12800.0 0.33 0.0873 0.227 1446 SPBio_002624 OC(COc1cccc2oc(cc(=O)c12)C(=O)O)COc3cccc4oc(cc(=O)c34)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D07 compound treatment 198680.0 -25200.0 -0.67 219840.0 3290.0 0.08 -0.4164 -0.6145 3173081 SPBio_002625 COCCc1ccc(OCC(O)CNC(C)C)cc1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D08 compound treatment 201320.0 -22600.0 -0.6 216080.0 -474.0 -0.01 -0.4342 -0.7211 3187884 SPBio_002626 CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(=O)(O)O[C@@H]4C3OC(=O)CCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D09 compound treatment 205680.0 -18200.0 -0.49 233200.0 16600.0 0.42 -0.0442 -0.0686 3187752 SPBio_002627 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D10 compound treatment 209880.0 -14000.0 -0.37 224600.0 8050.0 0.2 -0.1196 -0.2808 3176931 SPBio_002628 NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S(=O)(=O)O)C3=O)C(=O)O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D11 compound treatment 210120.0 -13800.0 -0.37 222600.0 6050.0 0.15 -0.1511 -0.3793 359 SPBio_002629 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D12 compound treatment 219240.0 -4660.0 -0.12 222520.0 5970.0 0.15 0.0194 0.0991 717 SPBio_002630 OC(=O)c1ccccc1OP(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D13 compound treatment 221040.0 -2860.0 -0.08 222960.0 6410.0 0.16 0.0613 0.3408 689 SPBio_002631 Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C(=O)O)s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D14 compound treatment 205440.0 -18500.0 -0.49 224080.0 7530.0 0.19 -0.2127 -0.4028 1102 SPBio_002632 CC(C(=O)O)c1ccc(cc1)C(=O)c2cccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D15 compound treatment 221640.0 -2260.0 -0.06 241480.0 24900.0 0.63 0.4056 0.6371 3173859 SPBio_002633 CC(C)CC(=O)OC1C(O[C@@H]2C[C@H]([C@H]3CC[C@]4(CC5CC[C@H]4[C@]3(C)C2)[C@@H](O)C5=C)C(=O)O)OC(CO)C(OS(=O)(=O)O)C1OS(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D16 compound treatment 221280.0 -2620.0 -0.07 261760.0 45200.0 1.15 0.7634 0.6629 1254 SPBio_002634 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D17 compound treatment 197320.0 -26600.0 -0.71 225400.0 8850.0 0.22 -0.342 -0.4601 873 SPBio_002635 Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CNc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D18 compound treatment 203000.0 -20900.0 -0.56 214040.0 -2510.0 -0.06 -0.4392 -0.7831 1055 SPBio_002636 CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D19 compound treatment 185640.0 -38300.0 -1.02 223600.0 7050.0 0.18 -0.5946 -0.5741 1402956 SPBio_002637 CC(N)C(O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D20 compound treatment 209280.0 -14600.0 -0.39 222040.0 5490.0 0.14 -0.177 -0.4275 1000139 SPBio_002638 CO[C@]1(NC(=O)C(C(=O)O)c2ccc(O)cc2)[C@H]3OCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D21 compound treatment 16360.0 -208000.0 -5.53 111240.0 -105000.0 -2.68 -5.8063 -0.9445 1531 SPBio_002639 O=c1n([se]c2ccccc12)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D22 compound treatment 198560.0 -25300.0 -0.68 219040.0 2490.0 0.06 -0.433 -0.6382 856 SPBio_002640 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D23 mock treatment 209840.0 -14100.0 -0.37 227560.0 11000.0 0.28 -0.0672 -0.1436 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 D24 mock treatment 207520.0 -16400.0 -0.44 183360.0 -33200.0 -0.84 -0.9056 -0.953 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E01 mock treatment 203800.0 -20100.0 -0.54 272880.0 56300.0 1.43 0.6338 0.4145 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E02 mock treatment 213520.0 -10400.0 -0.28 206560.0 -9990.0 -0.25 -0.3754 -0.9991 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E03 compound treatment 230400.0 6500.0 0.17 226480.0 9930.0 0.25 0.301 0.9832 3180327 SPBio_002641 COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E04 compound treatment 214880.0 -9020.0 -0.24 286000.0 69400.0 1.77 1.0786 0.6052 3069536 SPBio_002642 OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3c(=O)cc(oc23)c4ccc(O)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E05 compound treatment 203400.0 -20500.0 -0.55 232360.0 15800.0 0.4 -0.1023 -0.1508 1054667 SPBio_002643 CN1C(CC(O)c2ccccc2)CCCC1CC(O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E06 compound treatment 207400.0 -16500.0 -0.44 241840.0 25300.0 0.64 0.1436 0.1843 1001945 SPBio_002644 CN1C[C@@]2(C=C)C3CC4OCC3C1[C@@H]2[C@@]45C(=O)Nc6ccccc65 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E07 compound treatment 213640.0 -10300.0 -0.27 224200.0 7650.0 0.19 -0.0559 -0.1667 959 SPBio_002645 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E08 compound treatment 204520.0 -19400.0 -0.52 248280.0 31700.0 0.81 0.2051 0.2141 3187619 SPBio_002646 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)OC61CCC(C)CN6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E09 compound treatment 227480.0 3580.0 0.1 241960.0 25400.0 0.65 0.5243 0.8029 3000363 SPBio_002647 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E10 compound treatment 225560.0 1660.0 0.04 255080.0 38500.0 0.98 0.724 0.7383 3069538 SPBio_002648 CCN1C[C@]2(COC)CC[C@H](OC)[C@]3(C4C[C@H]5[C@H](OC)C4C6(C[C@@H]5OC)OCO[C@@]76[C@@H](O)C32)[C@@H]17 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E11 compound treatment 240480.0 16600.0 0.44 235360.0 18800.0 0.48 0.6507 0.9992 3061052 SPBio_002649 CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E12 compound treatment 231160.0 7260.0 0.19 238800.0 22200.0 0.57 0.5369 0.898 1054504 SPBio_002650 COc1c(OCC(O)C(C)(C)O)ccc2c(OC)c3ccoc3nc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E13 compound treatment 274560.0 50700.0 1.35 223680.0 7130.0 0.18 1.0833 0.7948 909 SPBio_002651 COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E14 compound treatment 241400.0 17500.0 0.47 231840.0 15300.0 0.39 0.6048 0.9959 3187620 SPBio_002652 C[C@H]1CCC[C@@H](C)N1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E15 compound treatment 142280.0 -81600.0 -2.18 148760.0 -67800.0 -1.72 -2.7577 -0.9933 3189572 SPBio_002653 CN1Cc2c3OCOc3ccc2[C@H]4[C@@H](O)Cc5cc6OCOc6cc5[C@H]41 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E16 compound treatment 205640.0 -18300.0 -0.49 235880.0 19300.0 0.49 0.0032 0.0047 1540789 SPBio_002654 COc1cc(=O)n(C)c2c(OCC(O)C(C)(C)O)cccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E17 compound treatment 199400.0 -24500.0 -0.65 256920.0 40400.0 1.03 0.2639 0.2169 1202 SPBio_002655 COc1ccc2CN(C)CC[C@]34C=C[C@H](O)C[C@@H]4Oc1c23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E18 compound treatment 212520.0 -11400.0 -0.3 269120.0 52600.0 1.34 0.7306 0.533 1054505 SPBio_002656 COc1ccc2c(OC)c3ccoc3nc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E19 compound treatment 240880.0 17000.0 0.45 238800.0 22200.0 0.57 0.7201 0.9939 1220 SPBio_002657 CN1CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E20 compound treatment 201800.0 -22100.0 -0.59 245880.0 29300.0 0.75 0.1106 0.1164 852250 SPBio_002658 C1CCC(NC1)c2cccnc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E21 compound treatment 213720.0 -10200.0 -0.27 219800.0 3250.0 0.08 -0.1335 -0.4708 3173993 SPBio_002659 O[C@H]1CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E22 compound treatment 245960.0 22100.0 0.59 244400.0 27800.0 0.71 0.9166 0.9958 193 SPBio_002660 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E23 mock treatment 213440.0 -10500.0 -0.28 229560.0 13000.0 0.33 0.0367 0.0847 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 E24 mock treatment 221560.0 -2340.0 -0.06 198800.0 -17800.0 -0.45 -0.3633 -0.7972 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F01 mock treatment 191240.0 -32700.0 -0.87 281440.0 64900.0 1.65 0.5509 0.2953 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F02 mock treatment 208920.0 -15000.0 -0.4 247400.0 30800.0 0.78 0.2722 0.3093 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F03 compound treatment 209880.0 -14000.0 -0.37 235720.0 19200.0 0.49 0.0803 0.1307 3069579 SPBio_002661 NC(=O)c1ccc[n+](c1)[C@H]2O[C@@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H](C(O)[C@H]3O)n4cnc5c(N)ncnc45)C(O)[C@H]2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F04 compound treatment 301800.0 77900.0 2.08 369000.0 152000.0 3.88 4.2096 0.9572 691 SPBio_002662 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2C1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F05 compound treatment 214760.0 -9140.0 -0.24 247960.0 31400.0 0.8 0.3924 0.47 799 SPBio_002663 Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F06 compound treatment 209600.0 -14300.0 -0.38 237120.0 20600.0 0.52 0.1002 0.1548 1303 SPBio_002664 C[N+]1(CCC2CC1)CC2OC(=O)C(O)(c3ccccc3)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F07 compound treatment 201520.0 -22400.0 -0.6 234320.0 17800.0 0.45 -0.1025 -0.137 3187753 SPBio_002665 C[C@H]1C[C@H]2[C@@H]3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)CCC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F08 compound treatment 313680.0 89800.0 2.39 261400.0 44800.0 1.14 2.499 0.9425 1529 SPBio_002666 COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F09 compound treatment 185760.0 -38100.0 -1.02 214000.0 -2550.0 -0.06 -0.765 -0.7507 3187754 SPBio_002667 CNCC(O)C(O)C(O)C(O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F10 compound treatment 213600.0 -10300.0 -0.27 234080.0 17500.0 0.45 0.1209 0.2311 1114 SPBio_002668 NS(=O)(=O)c1cc2c(N=C(CSCc3ccccc3)NS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F11 compound treatment 229240.0 5340.0 0.14 218320.0 1770.0 0.04 0.1325 0.887 3187755 SPBio_002669 CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F12 compound treatment 233880.0 9980.0 0.27 224960.0 8410.0 0.21 0.3393 0.9941 1000 SPBio_002670 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F13 compound treatment 241520.0 17600.0 0.47 227400.0 10800.0 0.28 0.5272 0.9678 3069580 SPBio_002671 C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F14 compound treatment 217280.0 -6620.0 -0.18 230400.0 13800.0 0.35 0.1242 0.3153 1052436 SPBio_002672 CCN(CC)CCc1nc(no1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F15 compound treatment 219000.0 -4900.0 -0.13 222680.0 6130.0 0.16 0.0178 0.0875 3069581 SPBio_002673 Cn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@H](O)c4ccccc4)C3=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F16 compound treatment 202160.0 -21700.0 -0.58 207360.0 -9190.0 -0.23 -0.5751 -0.9203 1397 SPBio_002674 CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F17 compound treatment 70920.0 -153000.0 -4.08 91200.0 -125000.0 -3.19 -5.1379 -0.9926 3187756 SPBio_002675 CC[C@]1(CC[C@@H](O1)[C@]2(C)CC[C@]3(C[C@H](O)[C@@H](C)[C@H](O3)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O2)[C@@H]4O[C@H](C[C@@H]4C)[C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F18 compound treatment 17080.0 -207000.0 -5.51 19280.0 -197000.0 -5.02 -7.4461 -0.9989 3187885 SPBio_002676 CC[C@H]([C@H]1O[C@@](CC)(C[C@@H]1C)[C@H]2CC[C@](O)(CC)[C@H](C)O2)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc3ccc(C)c(O)c3C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F19 compound treatment 204040.0 -19900.0 -0.53 226040.0 9490.0 0.24 -0.2038 -0.3504 4338 SPBio_002677 CCC(NC(C)C)C(O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F20 compound treatment 231440.0 7540.0 0.2 230160.0 13600.0 0.35 0.3868 0.9667 1519 SPBio_002678 CC1(C)OC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F21 compound treatment 200840.0 -23100.0 -0.61 243040.0 26500.0 0.67 0.0415 0.0455 3069582 SPBio_002679 C[C@@]1(O)CCOC(=O)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F22 compound treatment 216240.0 -7660.0 -0.2 224040.0 7490.0 0.19 -0.0098 -0.0351 852 SPBio_002680 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F23 mock treatment 225640.0 1740.0 0.05 338680.0 122000.0 3.11 2.2286 0.7176 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 F24 mock treatment 298280.0 74400.0 1.98 190840.0 -25700.0 -0.65 0.94 0.4502 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G01 mock treatment 215880.0 -8020.0 -0.21 227760.0 11200.0 0.28 0.0503 0.1412 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G02 mock treatment 201720.0 -22200.0 -0.59 233320.0 16800.0 0.43 -0.1167 -0.1601 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G03 compound treatment 204560.0 -19300.0 -0.52 237200.0 20600.0 0.52 0.0066 0.009 1000946 SPBio_002681 COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G04 compound treatment 156760.0 -67100.0 -1.79 198640.0 -17900.0 -0.46 -1.5879 -0.8596 3129 SPBio_002682 CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G05 compound treatment 217160.0 -6740.0 -0.18 260720.0 44200.0 1.12 0.667 0.5865 3054974 SPBio_002683 COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G06 compound treatment 243960.0 20100.0 0.53 311560.0 95000.0 2.42 2.0864 0.8433 1025381 SPBio_002684 COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G07 compound treatment 232200.0 8300.0 0.22 211360.0 -5190.0 -0.13 0.0631 0.2449 3189573 SPBio_002685 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)C3C[C@@H]21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G08 compound treatment 232560.0 8660.0 0.23 215760.0 -794.0 -0.02 0.149 0.6428 3187622 SPBio_002686 CCN1C[C@]2(C)CC[C@H](OC)[C@@]34C2[C@H](OC(=O)C)C5(OCO[C@]65C[C@H](OC)C7C[C@]4(O)C6[C@H]7OC)[C@@H]13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G09 compound treatment 239120.0 15200.0 0.41 215320.0 -1230.0 -0.03 0.2648 0.6505 915 SPBio_002687 OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G10 compound treatment 228720.0 4820.0 0.13 227040.0 10500.0 0.27 0.2794 0.944 1182082 SPBio_002688 Cn1c(cc(=O)c2ccccc12)c3ccc4OCOc4c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G11 compound treatment 247360.0 23500.0 0.63 215120.0 -1430.0 -0.04 0.4165 0.6648 1056553 SPBio_002689 CN1CCC23C4Nc5ccccc5C3(CCN4C)C1Nc6ccccc62 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G12 compound treatment 239040.0 15100.0 0.4 238480.0 21900.0 0.56 0.6797 0.9874 3069539 SPBio_002690 CN1CCC2=C[C@@H](O)[C@@H]3OC(=O)c4cc5OCOc5cc4C3[C@@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G13 compound treatment 202480.0 -21400.0 -0.57 208240.0 -8310.0 -0.21 -0.5533 -0.9086 3069519 SPBio_002691 COc1ccc(cc1OC)C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G14 compound treatment 41520.0 -182000.0 -4.86 47920.0 -169000.0 -4.29 -6.4704 -0.998 3187623 SPBio_002692 CC=C(C)C(=O)OC1[C@H](OC(=O)C)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(OC6OC([C@H](O[C@H]7OC(CO)[C@H](O)[C@H](O)C7O)[C@H](O)C6O[C@H]8OC(CO)[C@H](O)[C@H](O)C8O)C(=O)O)[C@](C)(CO)C5CCC43C)C2CC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G15 compound treatment 229560.0 5660.0 0.15 228960.0 12400.0 0.32 0.3298 0.9431 2060325 SPBio_002693 COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(c34)-c2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G16 compound treatment 18800.0 -205000.0 -5.47 19600.0 -197000.0 -5.01 -7.4079 -0.999 829 SPBio_002694 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G17 compound treatment 206880.0 -17000.0 -0.45 230320.0 13800.0 0.35 -0.0734 -0.128 1076 SPBio_002695 Cc1cccc(C)c1NC2=NCCCS2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G18 compound treatment 240520.0 16600.0 0.44 247360.0 30800.0 0.78 0.8672 0.9636 1115322 SPBio_002696 COc1ccn(C)c(=O)c1C#N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G19 compound treatment 228000.0 4100.0 0.11 243680.0 27100.0 0.69 0.565 0.8091 3179848 SPBio_002697 C/C=C\1/CC(=C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G20 compound treatment 232600.0 8700.0 0.23 247120.0 30600.0 0.78 0.7136 0.8798 3069540 SPBio_002698 CCN1C[C@]2(COC)CC[C@H](O)[C@]3(C4C[C@H]5C(OC)C4[C@](O)(C[C@H]5OC)C6(O)C(OC)C32)[C@H]16 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G21 compound treatment 236680.0 12800.0 0.34 278920.0 62400.0 1.59 1.3623 0.8399 1737132 SPBio_002699 COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c2c34)cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G22 compound treatment 229200.0 5300.0 0.14 227920.0 11400.0 0.29 0.3043 0.9459 3187624 SPBio_002700 C/C=C\1/C[N@@+]2(C)CCC34[C@@H]2C[C@@H]1C(=C4Nc5ccccc53)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G23 mock treatment 227280.0 3380.0 0.09 229480.0 12900.0 0.33 0.2962 0.869 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 G24 mock treatment 206960.0 -16900.0 -0.45 146640.0 -69900.0 -1.78 -1.5764 -0.8594 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H01 mock treatment 220360.0 -3540.0 -0.09 221160.0 4610.0 0.12 0.0161 0.107 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H02 mock treatment 220080.0 -3820.0 -0.1 212920.0 -3630.0 -0.09 -0.1373 -0.9988 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H03 compound treatment 242480.0 18600.0 0.5 225000.0 8450.0 0.21 0.5022 0.93 3480633 SPBio_002701 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H04 compound treatment 195960.0 -27900.0 -0.74 199000.0 -17600.0 -0.45 -0.8423 -0.97 1452 SPBio_002702 CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H05 compound treatment 249040.0 25100.0 0.67 243640.0 27100.0 0.69 0.961 0.9999 1404 SPBio_002703 Nc1ccc(N=Nc2ccccc2)c(N)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H06 compound treatment 252240.0 28300.0 0.76 239240.0 22700.0 0.58 0.9422 0.9911 1189 SPBio_002704 CO[C@]1(NC(=O)Cc2cccs2)[C@H]3SCC(=C(N3C1=O)C(=O)O)COC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H07 compound treatment 254480.0 30600.0 0.82 248440.0 31900.0 0.81 1.1498 1.0 1451 SPBio_002705 CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H08 compound treatment 242480.0 18600.0 0.5 224480.0 7930.0 0.2 0.4928 0.9214 1000080 SPBio_002706 ClCCNP1(=O)OCCCN1CCCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H09 compound treatment 276800.0 52900.0 1.41 224200.0 7650.0 0.19 1.1348 0.797 1438 SPBio_002707 CC(C(=O)O)c1cccc(Oc2ccccc2)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H10 compound treatment 244320.0 20400.0 0.54 225560.0 9010.0 0.23 0.5469 0.9259 3187886 SPBio_002708 CO[C@@H]1[C@H](OC(=O)N)C(O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H11 compound treatment 250320.0 26400.0 0.7 218360.0 1810.0 0.05 0.5306 0.7516 963 SPBio_002709 CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4)C(=O)C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H12 compound treatment 235600.0 11700.0 0.31 232960.0 16400.0 0.42 0.5156 0.9898 1232 SPBio_002710 OC1=C(O)C(=O)C(=C(O)C1=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H13 compound treatment 22360.0 -202000.0 -5.37 37600.0 -179000.0 -4.55 -7.0171 -0.9966 1138 SPBio_002711 CC/C(=C(/CC)\c1ccc(O)cc1)/c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H14 compound treatment 183640.0 -40300.0 -1.07 183440.0 -33100.0 -0.84 -1.3544 -0.9928 1029 SPBio_002712 CC(C(=O)O)c1ccc(cc1)N2Cc3ccccc3C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H15 compound treatment 220160.0 -3740.0 -0.1 212920.0 -3630.0 -0.09 -0.1358 -0.9993 3057880 SPBio_002713 COc1ccc(cc1)C(=C(c2ccc(OC)cc2)c3ccc(OC)cc3)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H16 compound treatment 258760.0 34900.0 0.93 245320.0 28800.0 0.73 1.1744 0.993 1276 SPBio_002714 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H17 compound treatment 178280.0 -45600.0 -1.22 193400.0 -23200.0 -0.59 -1.2764 -0.9445 3187757 SPBio_002715 NCC1OC(OC2C(N)CC(N)C(O)C2O[C@@H]3O[C@H](CO)[C@H](O)C3O)C(N)C(O)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H18 compound treatment 256000.0 32100.0 0.86 252720.0 36200.0 0.92 1.2555 0.9994 3187887 SPBio_002716 CC(CN(C(=O)C)c1c(I)cc(I)c(N)c1I)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H19 compound treatment 249800.0 25900.0 0.69 251000.0 34400.0 0.88 1.1076 0.9931 1094620 SPBio_002717 CC(C[N+](C)(C)C)OC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H20 compound treatment 245120.0 21200.0 0.57 233680.0 17100.0 0.44 0.708 0.9916 1670 SPBio_002718 Nc1nc2n(COC(CO)CO)cnc2c(=O)[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H21 compound treatment 219880.0 -4020.0 -0.11 246040.0 29500.0 0.75 0.4544 0.6 1246 SPBio_002719 CC[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H22 compound treatment 236520.0 12600.0 0.34 232280.0 15700.0 0.4 0.5207 0.9963 727 SPBio_002720 CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H23 mock treatment 233400.0 9500.0 0.25 221720.0 5170.0 0.13 0.272 0.9532 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 H24 mock treatment 239840.0 15900.0 0.43 153520.0 -63000.0 -1.6 -0.8328 -0.5022 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I01 mock treatment 219400.0 -4500.0 -0.12 200960.0 -15600.0 -0.4 -0.3652 -0.8816 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I02 mock treatment 201080.0 -22800.0 -0.61 219040.0 2490.0 0.06 -0.3855 -0.6303 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I03 compound treatment 143520.0 -80400.0 -2.14 161720.0 -54800.0 -1.39 -2.5013 -0.9783 3069520 SPBio_002721 COc1ccc2CC3N(CCc4cc(OC)c(O)cc34)Cc2c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I04 compound treatment 201520.0 -22400.0 -0.6 222840.0 6290.0 0.16 -0.3089 -0.5001 3069541 SPBio_002722 C[C@H]1[C@H]2[C@H](OC1=O)[C@H]3C(=CC(=O)C3=C(C)C[C@@H]2O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I05 compound treatment 213040.0 -10900.0 -0.29 226720.0 10200.0 0.26 -0.0219 -0.0565 3069521 SPBio_002723 CCC1[C@@H](O)N2C3C[C@@]45[C@H](O)C3C1CC2[C@@H]5N(C)c6ccccc64 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I06 compound treatment 196000.0 -27900.0 -0.74 217640.0 1090.0 0.03 -0.5065 -0.6804 3187625 SPBio_002724 CC[N+]1(C)C2CCC1CC(C2)OC(=O)[C@H]3CCC(C(=O)OC4CC5CCC(C4)[N+]5(C)CC)(c6ccccc6)c7ccccc37 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I07 compound treatment 230840.0 6940.0 0.19 223240.0 6690.0 0.17 0.2511 0.9991 1539 SPBio_002725 C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)[C@H]23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I08 compound treatment 240200.0 16300.0 0.43 222560.0 6010.0 0.15 0.4153 0.9015 3173628 SPBio_002726 CN1C(C)(C)CCCC1(C)C.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I09 compound treatment 69280.0 -155000.0 -4.12 68200.0 -148000.0 -3.77 -5.5824 -0.999 3069522 SPBio_002727 COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I10 compound treatment 233040.0 9140.0 0.24 212160.0 -4390.0 -0.11 0.0933 0.3481 3069542 SPBio_002728 COC(C)C(O)(C(C)C)C(=O)OCC1=CCN2CC[C@H](O)[C@H]21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I11 compound treatment 226120.0 2220.0 0.06 214920.0 -1630.0 -0.04 0.0125 0.1728 3100 SPBio_002729 COc1c2OCOc2cc3CCN(C)Cc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I12 compound treatment 226120.0 2220.0 0.06 225720.0 9170.0 0.23 0.2067 0.8595 3487155 SPBio_002730 C1CNC2C(C1)C3CCC2C4N3CCc5c4[nH]c6ccccc56 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I13 compound treatment 229960.0 6060.0 0.16 237440.0 20900.0 0.53 0.4898 0.8823 3189574 SPBio_002731 O[C@H]([C@@H]1CC2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I14 compound treatment 161600.0 -62300.0 -1.66 175960.0 -40600.0 -1.03 -1.9044 -0.9738 3069543 SPBio_002732 O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@@H](C32)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I15 compound treatment 204640.0 -19300.0 -0.51 199880.0 -16700.0 -0.42 -0.6629 -0.9955 1039 SPBio_002733 CC[C@]1(CCCN2CCc3c4[C@@H]21)CC(=O)n4c5ccccc35 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I16 compound treatment 229000.0 5100.0 0.14 245240.0 28700.0 0.73 0.6119 0.8248 3187744 SPBio_002734 CCN1C[C@]2(C)CC[C@H](O)C3(C4C[C@H]5C(O)C4[C@](O)(C[C@@H]5OC)C6CC32)[C@H]61 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I17 compound treatment 235640.0 11700.0 0.31 235800.0 19200.0 0.49 0.5674 0.9767 3069523 SPBio_002735 O[C@@H]([C@H]1CC2CCN1C[C@H]2C=C)c3ccnc4ccccc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I18 compound treatment 205320.0 -18600.0 -0.5 221000.0 4450.0 0.11 -0.2703 -0.5321 3187745 SPBio_002736 C[C@@]12CC[C@H]3[C@@H](CCc4cc(OS(=O)(=O)O)ccc34)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I19 compound treatment 222960.0 -938.0 -0.03 226960.0 10400.0 0.26 0.1694 0.6374 3189575 SPBio_002737 N[C@H](CCONC(=N)N)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I20 compound treatment 232120.0 8220.0 0.22 243000.0 26400.0 0.67 0.6305 0.8914 3069544 SPBio_002738 CO[C@@H]1C=C2CCN(C)[C@@H]2C3[C@H]1OC(=O)c4cc5OCOc5cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I21 compound treatment 220160.0 -3740.0 -0.1 234880.0 18300.0 0.47 0.259 0.5435 1530 SPBio_002739 COc1ccc2c3CCN=C(C)c3[nH]c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I22 compound treatment 227960.0 4060.0 0.11 265120.0 48600.0 1.23 0.9498 0.7662 3187746 SPBio_002740 CCN1C[C@]2(C)CC[C@H](O)C3(C2CC4[C@H]13)C5C[C@H](O)C6C[C@]45[C@H](O)C6=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I23 mock treatment 207840.0 -16100.0 -0.43 235520.0 19000.0 0.48 0.0382 0.0593 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 I24 mock treatment 221240.0 -2660.0 -0.07 190400.0 -26200.0 -0.67 -0.5204 -0.7781 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J01 mock treatment 226440.0 2540.0 0.07 205240.0 -11300.0 -0.29 -0.1555 -0.5261 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J02 mock treatment 204400.0 -19500.0 -0.52 215240.0 -1310.0 -0.03 -0.3912 -0.751 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J03 compound treatment 60760.0 -163000.0 -4.35 82960.0 -134000.0 -3.4 -5.4776 -0.9925 1429 SPBio_002741 CCCCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J04 compound treatment 158560.0 -65300.0 -1.74 163760.0 -52800.0 -1.34 -2.181 -0.9917 3187888 SPBio_002742 O=C1OC2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J05 compound treatment 222080.0 -1820.0 -0.05 225880.0 9330.0 0.24 0.1334 0.5511 867 SPBio_002743 Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J06 compound treatment 220960.0 -2940.0 -0.08 227440.0 10900.0 0.28 0.1403 0.4878 3044756 SPBio_002744 CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J07 compound treatment 225080.0 1180.0 0.03 210120.0 -6430.0 -0.16 -0.0934 -0.5606 1001 SPBio_002745 CN(C)CCOC(=O)COc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J08 compound treatment 227120.0 3220.0 0.09 213440.0 -3110.0 -0.08 0.0047 0.0406 3187889 SPBio_002746 CCOc1ccc2ccccc2c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J09 compound treatment 233760.0 9860.0 0.26 215200.0 -1350.0 -0.03 0.1616 0.6093 3069584 SPBio_002747 [O-][N+](=O)c1ccc(/C=N/N2CC(CN3CCOCC3)OC2=O)o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J10 compound treatment 246680.0 22800.0 0.61 246240.0 29700.0 0.75 0.9632 0.9942 1057 SPBio_002748 OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J11 compound treatment 244720.0 20800.0 0.56 238400.0 21800.0 0.56 0.7853 1.0 837 SPBio_002749 CCOc1ccc2NC(C)(C)C=C(C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J12 compound treatment 257080.0 33200.0 0.88 225880.0 9330.0 0.24 0.7933 0.8661 3069693 SPBio_002750 CN(C)CCCO[C@H]1[C@H](OC2OC(C)(C)O[C@@H]12)C(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J13 compound treatment 228680.0 4780.0 0.13 234280.0 17700.0 0.45 0.4088 0.8729 2575 SPBio_002751 CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J14 compound treatment 149120.0 -74800.0 -1.99 208080.0 -8470.0 -0.22 -1.5622 -0.779 2710 SPBio_002752 COc1ccc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(O)C#C)[C@@H]3CCc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J15 compound treatment 225040.0 1140.0 0.03 215200.0 -1350.0 -0.03 -0.0028 -0.0615 3187758 SPBio_002753 NC(=N)NCC1COC2(CCCCC2)O1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J16 compound treatment 235480.0 11600.0 0.31 223000.0 6450.0 0.16 0.3342 0.9561 3452 SPBio_002754 CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J17 compound treatment 236880.0 13000.0 0.35 231360.0 14800.0 0.38 0.5109 0.9991 3060003 SPBio_002755 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](O)C3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J18 compound treatment 239680.0 15800.0 0.42 239840.0 23300.0 0.59 0.7162 0.986 3487254 SPBio_002756 CC(=O)N(CC(O)CN(C(=O)C)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c2c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c2I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J19 compound treatment 222840.0 -1060.0 -0.03 208120.0 -8430.0 -0.21 -0.1716 -0.7933 1094 SPBio_002757 COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J20 compound treatment 228680.0 4780.0 0.13 232440.0 15900.0 0.4 0.3758 0.8871 3069696 SPBio_002758 CN(C)[C@H]1C2CC3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCN4CCCC4)C(=O)c5c(O)cccc5[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J21 compound treatment 221760.0 -2140.0 -0.06 247480.0 30900.0 0.79 0.5157 0.6541 888 SPBio_002759 CC(C)[N+](C)(CCC(C(=O)N)(c1ccccc1)c2ccccc2)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J22 compound treatment 218760.0 -5140.0 -0.14 236880.0 20300.0 0.52 0.2686 0.5023 1405 SPBio_002760 C[C@@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J23 mock treatment 220240.0 -3660.0 -0.1 239800.0 23200.0 0.59 0.349 0.5825 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 J24 mock treatment 224520.0 622.0 0.02 197280.0 -19300.0 -0.49 -0.3348 -0.6828 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K01 mock treatment 224120.0 222.0 0.01 174520.0 -42000.0 -1.07 -0.7516 -0.7032 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K02 mock treatment 209880.0 -14000.0 -0.37 237360.0 20800.0 0.53 0.1098 0.1695 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K03 compound treatment 232560.0 8660.0 0.23 224560.0 8010.0 0.2 0.3072 0.998 1578 SPBio_002761 CC1=NCCc2c1[nH]c3cc(O)ccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K04 compound treatment 195520.0 -28400.0 -0.76 230800.0 14200.0 0.36 -0.2789 -0.3325 3187747 SPBio_002762 COc1cc(ccc1O)C(=O)OC2CC3CCC(C2)N3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K05 compound treatment 250160.0 26300.0 0.7 207800.0 -8750.0 -0.22 0.3377 0.4597 1043296 SPBio_002763 Cc1nccc2c3ccc(O)cc3[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K06 compound treatment 244240.0 20300.0 0.54 242560.0 26000.0 0.66 0.8511 0.9952 3187748 SPBio_002764 CC(=O)O[C@H]1C2[C@]3([C@H]4[C@@H]5[C@@H](O)[C@@H]1C(=C)CC52CC6C37)[C@H](OC(=O)C)[C@H](C[C@@]7(C)CN46)OC(=O)c8ccccc8 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K07 compound treatment 204800.0 -19100.0 -0.51 217960.0 1410.0 0.04 -0.3348 -0.6559 297849 SPBio_002765 COc1ccc2c(c1)[nH]c3c(C)nccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K08 compound treatment 237800.0 13900.0 0.37 225360.0 8810.0 0.22 0.4204 0.9709 1047 SPBio_002766 CN(C)CCCN1c2ccccc2Sc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K09 compound treatment 21520.0 -202000.0 -5.4 20360.0 -196000.0 -4.99 -7.3429 -0.9992 2057 SPBio_002767 Cc1c2[nH]c3ccccc3c2c(C)c4cnccc14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K10 compound treatment 227600.0 3700.0 0.1 248440.0 31900.0 0.81 0.6431 0.7874 1177 SPBio_002768 Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K11 compound treatment 33240.0 -191000.0 -5.08 42240.0 -174000.0 -4.43 -6.7286 -0.9977 3069524 SPBio_002769 O=C1C=CC(=O)c2c1ccc3c2ccc4ccccc43 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K12 compound treatment 250680.0 26800.0 0.71 289080.0 72500.0 1.84 1.8089 0.9147 1463 SPBio_002770 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K13 compound treatment 243280.0 19400.0 0.52 223800.0 7250.0 0.18 0.4957 0.9035 3189576 SPBio_002771 CN(CCCCCCCCCCN(C)C(=O)Oc1ccccc1[N+](C)(C)C)C(=O)Oc2ccccc2[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K14 compound treatment 213920.0 -9980.0 -0.27 231520.0 15000.0 0.38 0.0809 0.1743 1424515 SPBio_002772 CCN1C(=O)NC(C1=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K15 compound treatment 223400.0 -498.0 -0.01 236360.0 19800.0 0.5 0.3467 0.6882 1494 SPBio_002773 C1CN(CCN1)c2ccc3ccccc3n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K16 compound treatment 234880.0 11000.0 0.29 234480.0 17900.0 0.46 0.5293 0.9771 3069570 SPBio_002774 C[C@@]12CCC3[C@@H](CC[C@@H]4C[C@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K17 compound treatment 253400.0 29500.0 0.79 231560.0 15000.0 0.38 0.826 0.9448 3069525 SPBio_002775 C1CCN2C[C@@H]3C[C@H](CN4CCCC[C@H]34)[C@@H]2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K18 compound treatment 232320.0 8420.0 0.22 242120.0 25600.0 0.65 0.6184 0.8992 1444 SPBio_002776 C1CN=C(N1)C2CCCc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K19 compound treatment 257240.0 33300.0 0.89 247640.0 31100.0 0.79 1.1875 0.9983 3043 SPBio_002777 C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)C)C(=O)COC(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K20 compound treatment 18880.0 -205000.0 -5.47 17680.0 -199000.0 -5.06 -7.4409 -0.9992 1070 SPBio_002778 CCC(C(CC)c1ccc(O)cc1)c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K21 compound treatment 234960.0 11100.0 0.29 217240.0 686.0 0.02 0.2209 0.7476 1035065 SPBio_002779 Cc1nccc2c3ccccc3[nH]c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K22 compound treatment 260720.0 36800.0 0.98 223560.0 7010.0 0.18 0.8202 0.822 1000312 SPBio_002780 CO[C@]1(NC(=O)CSCC#N)[C@H]2SCC(=C(N2C1=O)C(=O)O)CSc3nnnn3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K23 mock treatment 233880.0 9980.0 0.27 222480.0 5930.0 0.15 0.2947 0.9637 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 K24 mock treatment 244400.0 20500.0 0.55 201120.0 -15400.0 -0.39 0.109 0.162 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L01 mock treatment 256920.0 33000.0 0.88 181040.0 -35500.0 -0.9 -0.016 -0.0127 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L02 mock treatment 243400.0 19500.0 0.52 204800.0 -11800.0 -0.3 0.1563 0.2607 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L03 compound treatment 232720.0 8820.0 0.24 253640.0 37100.0 0.94 0.8331 0.8572 3187759 SPBio_002781 CCC(=O)OCC(=O)C1(OC(=O)CC)[C@H](C)C[C@H]2[C@@H]3[C@H](Cl)CC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L04 compound treatment 283320.0 59400.0 1.58 225440.0 8890.0 0.23 1.2801 0.7999 712 SPBio_002782 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSc3ccncc3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L05 compound treatment 233120.0 9220.0 0.25 218360.0 1810.0 0.05 0.2063 0.8249 1499 SPBio_002783 Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L06 compound treatment 248320.0 24400.0 0.65 241440.0 24900.0 0.63 0.9079 0.9999 3187892 SPBio_002784 C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)C3(O)C(=C2C(=O)c4c(O)cccc14)O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L07 compound treatment 224720.0 822.0 0.02 239480.0 22900.0 0.58 0.4277 0.7332 3069624 SPBio_002785 CC[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L08 compound treatment 245440.0 21500.0 0.57 216840.0 286.0 0.01 0.4113 0.716 1000323 SPBio_002786 N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L09 compound treatment 232160.0 8260.0 0.22 286160.0 69600.0 1.77 1.4072 0.789 3187760 SPBio_002787 CC(=O)OCC(=O)[C@]12OC(C)(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]31C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L10 compound treatment 249360.0 25500.0 0.68 254720.0 38200.0 0.97 1.1662 0.9847 3187893 SPBio_002788 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC3OC(C)CC(C3O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L11 compound treatment 236760.0 12900.0 0.34 238880.0 22300.0 0.57 0.6439 0.9709 934 SPBio_002789 Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L12 compound treatment 270920.0 47000.0 1.25 274840.0 58300.0 1.48 1.9344 0.9965 1000270 SPBio_002790 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L13 compound treatment 238520.0 14600.0 0.39 261440.0 44900.0 1.14 1.0827 0.8977 896 SPBio_002791 COc1ccccc1OCC(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L14 compound treatment 253040.0 29100.0 0.78 222720.0 6170.0 0.16 0.6603 0.833 865 SPBio_002792 Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L15 compound treatment 22360.0 -202000.0 -5.37 19360.0 -197000.0 -5.01 -7.3451 -0.9994 1324 SPBio_002793 CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L16 compound treatment 227600.0 3700.0 0.1 211920.0 -4630.0 -0.12 -0.0135 -0.088 3069698 SPBio_002794 CC(C)(C)NC[C@@H](O)COc1cccc2C(=O)CCCc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L17 compound treatment 211560.0 -12300.0 -0.33 172680.0 -43900.0 -1.12 -1.0214 -0.8782 1338 SPBio_002795 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L18 compound treatment 242680.0 18800.0 0.5 199640.0 -16900.0 -0.43 0.05 0.0757 1215118 SPBio_002796 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L19 compound treatment 201560.0 -22300.0 -0.6 227920.0 11400.0 0.29 -0.2168 -0.3275 1533 SPBio_002797 Cc1cc(CC(=O)O)n(C)c1C(=O)c2ccc(Cl)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L20 compound treatment 60920.0 -163000.0 -4.35 51040.0 -166000.0 -4.21 -6.0485 -0.9999 1736 SPBio_002798 CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c(c2ccc(F)cc2)c3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L21 compound treatment 215360.0 -8540.0 -0.23 231640.0 15100.0 0.38 0.1103 0.2472 956 SPBio_002799 CCn1nc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L22 compound treatment 234640.0 10700.0 0.29 217520.0 966.0 0.02 0.2199 0.7649 3069699 SPBio_002800 C[C@@H]1NC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L23 mock treatment 206440.0 -17500.0 -0.47 242880.0 26300.0 0.67 0.1442 0.1768 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 L24 mock treatment 236560.0 12700.0 0.34 203240.0 -13300.0 -0.34 -7.0E-4 -0.0014 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M01 mock treatment 253760.0 29900.0 0.8 183440.0 -33100.0 -0.84 -0.0324 -0.0279 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M02 mock treatment 210440.0 -13500.0 -0.36 202800.0 -13800.0 -0.35 -0.501 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M03 compound treatment 206800.0 -17100.0 -0.46 190320.0 -26200.0 -0.67 -0.794 -0.9828 1048750 SPBio_002801 COc1ccc2[nH]c3C(=NCCc3c2c1)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M04 compound treatment 222120.0 -1780.0 -0.05 205680.0 -10900.0 -0.28 -0.229 -0.8165 1005 SPBio_002802 OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M05 compound treatment 212640.0 -11300.0 -0.3 202840.0 -13700.0 -0.35 -0.4588 -0.9972 3069526 SPBio_002803 C[N+]1(C)CCC[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M06 compound treatment 222560.0 -1340.0 -0.04 256680.0 40100.0 1.02 0.6962 0.682 1603 SPBio_002804 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M07 compound treatment 242120.0 18200.0 0.49 204080.0 -12500.0 -0.32 0.1193 0.2055 2709 SPBio_002805 Cc1ncc(CO)c(CO)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M08 compound treatment 218000.0 -5900.0 -0.16 189520.0 -27000.0 -0.69 -0.5973 -0.847 907320 SPBio_002806 CC(C)c1c(CN(C)C(C)Cc2ccccc2)n(C)n(c3ccccc3)c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M09 compound treatment 219520.0 -4380.0 -0.12 211120.0 -5430.0 -0.14 -0.1803 -0.9965 3189578 SPBio_002807 O=c1cccc2[C@@H]3CNCC(C3)Cn21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M10 compound treatment 224440.0 542.0 0.01 208040.0 -8510.0 -0.22 -0.1429 -0.6585 955 SPBio_002808 CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M11 compound treatment 219360.0 -4540.0 -0.12 218120.0 1570.0 0.04 -0.0574 -0.4507 1039072 SPBio_002809 CN1C2CCCC1CC(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M12 compound treatment 21280.0 -203000.0 -5.4 17800.0 -199000.0 -5.05 -7.3935 -0.9994 1286 SPBio_002810 Cc1cc(ccc1OCCOCC[N+](C)(C)Cc2ccccc2)C(C)(C)CC(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M13 compound treatment 231360.0 7460.0 0.2 220880.0 4330.0 0.11 0.2185 0.961 3189579 SPBio_002811 CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M14 compound treatment 217440.0 -6460.0 -0.17 202000.0 -14600.0 -0.37 -0.3834 -0.9394 863 SPBio_002812 CN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M15 compound treatment 223520.0 -378.0 -0.01 203840.0 -12700.0 -0.32 -0.2357 -0.7288 3069527 SPBio_002813 Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@H](CCC(=O)O)C(=O)O)cnc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M16 compound treatment 217960.0 -5940.0 -0.16 204880.0 -11700.0 -0.3 -0.3219 -0.9567 1441 SPBio_002814 CN1CCC(CC1)OC(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M17 compound treatment 212280.0 -11600.0 -0.31 190760.0 -25800.0 -0.66 -0.6828 -0.9414 3189580 SPBio_002815 C[C@@H]1NCCc2cc(O)c(O)cc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M18 compound treatment 19760.0 -204000.0 -5.44 16760.0 -200000.0 -5.08 -7.4408 -0.9994 1373 SPBio_002816 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M19 compound treatment 194160.0 -29700.0 -0.79 201560.0 -15000.0 -0.38 -0.8303 -0.9437 1014994 SPBio_002817 CN(C)Cc1c[nH]c2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M20 compound treatment 215560.0 -8340.0 -0.22 212080.0 -4470.0 -0.11 -0.2376 -0.9516 1012 SPBio_002818 Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M21 compound treatment 213040.0 -10900.0 -0.29 199800.0 -16800.0 -0.43 -0.5059 -0.9823 3189581 SPBio_002819 CCCCc1cc2ccccc2c(OCCN(C)C)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M22 compound treatment 26280.0 -198000.0 -5.27 19840.0 -197000.0 -5.0 -7.2625 -0.9997 2117332 SPBio_002820 C[C@@]12CC[C@H]3[C@@H](CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]2(O)CC[C@@H]1C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M23 mock treatment 200520.0 -23400.0 -0.62 192280.0 -24300.0 -0.62 -0.8772 -1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 M24 mock treatment 221360.0 -2540.0 -0.07 179480.0 -37100.0 -0.94 -0.7144 -0.7559 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N01 mock treatment 241280.0 17400.0 0.46 202480.0 -14100.0 -0.36 0.0747 0.1275 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N02 mock treatment 228880.0 4980.0 0.13 200440.0 -16100.0 -0.41 -0.1958 -0.4546 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N03 compound treatment 231760.0 7860.0 0.21 205520.0 -11000.0 -0.28 -0.0502 -0.1433 3069627 SPBio_002821 CCC(=O)OC1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)CCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N04 compound treatment 233080.0 9180.0 0.24 208960.0 -7590.0 -0.19 0.0366 0.1173 1764 SPBio_002822 NCC1(CC(=O)O)CCCCC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N05 compound treatment 129160.0 -94700.0 -2.53 144320.0 -72200.0 -1.84 -3.0848 -0.9877 1001531 SPBio_002823 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N06 compound treatment 40400.0 -183000.0 -4.89 24680.0 -192000.0 -4.88 -6.9093 -1.0 1694 SPBio_002824 Oc1ccc(cc1)c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N07 compound treatment 229720.0 5820.0 0.16 181800.0 -34800.0 -0.88 -0.5151 -0.5741 877 SPBio_002825 CC(C)(Oc1ccc(Cl)cc1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N08 compound treatment 236400.0 12500.0 0.33 187800.0 -28800.0 -0.73 -0.2813 -0.3501 2764 SPBio_002826 CC(O)(P(=O)(O)O)P(=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N09 compound treatment 233760.0 9860.0 0.26 197600.0 -19000.0 -0.48 -0.1549 -0.2821 917 SPBio_002827 NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N10 compound treatment 221200.0 -2700.0 -0.07 211200.0 -5350.0 -0.14 -0.1471 -0.9556 3069700 SPBio_002828 C[C@H]1NC(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N11 compound treatment 161880.0 -62000.0 -1.65 151080.0 -65500.0 -1.66 -2.3464 -1.0 1481 SPBio_002829 Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc4ccccc14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N12 compound treatment 30760.0 -193000.0 -5.15 37640.0 -179000.0 -4.55 -6.858 -0.9981 1000094 SPBio_002830 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N13 compound treatment 218200.0 -5700.0 -0.15 213640.0 -2910.0 -0.07 -0.1598 -0.9455 3092 SPBio_002831 Cn1ccnc1S 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N14 compound treatment 60880.0 -163000.0 -4.35 41760.0 -175000.0 -4.44 -6.2161 -0.9999 3187895 SPBio_002832 Nc1ncn(C2O[C@H](CO)[C@H](O)[C@@H]2O)c(=O)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N15 compound treatment 210080.0 -13800.0 -0.37 204840.0 -11700.0 -0.3 -0.4711 -0.9944 1043 SPBio_002833 O[Hg]c1c(O)c(Br)cc2c(c3ccccc3C(=O)O)c4cc(Br)c(=O)cc4oc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N16 compound treatment 233640.0 9740.0 0.26 192760.0 -23800.0 -0.61 -0.2441 -0.3708 3187896 SPBio_002834 NCC1OC(O[C@@H]2C(O)[C@H](OC3C(O)C(N)CC(N)C3OC4OC(CO)C(O)C(O)C4N)O[C@@H]2CO)C(N)C(O)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N17 compound treatment 224440.0 542.0 0.01 186680.0 -29900.0 -0.76 -0.5269 -0.6935 3187761 SPBio_002835 CC(CNC1CCCCC1)OC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N18 compound treatment 221160.0 -2740.0 -0.07 183000.0 -33600.0 -0.85 -0.6549 -0.7648 1267 SPBio_002836 CC(=O)Nc1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N19 compound treatment 215600.0 -8300.0 -0.22 176000.0 -40600.0 -1.03 -0.8856 -0.8397 793 SPBio_002837 CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N20 compound treatment 218920.0 -4980.0 -0.13 192120.0 -24400.0 -0.62 -0.5332 -0.8392 1604 SPBio_002838 OC(=O)c1ccccc1C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccs3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N21 compound treatment 95280.0 -129000.0 -3.43 80240.0 -136000.0 -3.47 -4.8757 -1.0 2080598 SPBio_002839 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC2CC(=O)NC(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N22 compound treatment 146960.0 -76900.0 -2.05 125760.0 -90800.0 -2.31 -3.083 -0.9983 2137 SPBio_002840 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccc(O)c(O)c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N23 mock treatment 218760.0 -5140.0 -0.14 207720.0 -8830.0 -0.22 -0.2557 -0.9719 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 N24 mock treatment 243640.0 19700.0 0.53 200080.0 -16500.0 -0.42 0.076 0.113 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O01 mock treatment 227800.0 3900.0 0.1 215040.0 -1510.0 -0.04 0.0463 0.4177 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O02 mock treatment 230680.0 6780.0 0.18 214800.0 -1750.0 -0.04 0.0963 0.5172 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O03 compound treatment 247120.0 23200.0 0.62 218320.0 1770.0 0.04 0.4696 0.7564 3382 SPBio_002841 Cc1c(CCO)sc[n+]1Cc2cnc(C)nc2N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O04 compound treatment 219320.0 -4580.0 -0.12 192800.0 -23800.0 -0.6 -0.5134 -0.8332 1155 SPBio_002842 Nc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O05 compound treatment 265880.0 42000.0 1.12 189760.0 -26800.0 -0.68 0.3097 0.2364 3487152 SPBio_002843 CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O06 compound treatment 209800.0 -14100.0 -0.38 137040.0 -79500.0 -2.02 -1.6954 -0.8244 1513 SPBio_002844 CCOC(=O)c1ccc(N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O07 compound treatment 213800.0 -10100.0 -0.27 173560.0 -43000.0 -1.09 -0.9634 -0.8557 2041 SPBio_002845 OC(=O)CNC(=O)C(CS)Cc1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O08 compound treatment 256520.0 32600.0 0.87 175280.0 -41300.0 -1.05 -0.1271 -0.0932 1242 SPBio_002846 CN(CS(=O)(=O)O)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O09 compound treatment 272480.0 48600.0 1.3 172480.0 -44100.0 -1.12 0.1235 0.0721 1015808 SPBio_002847 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)CO)c2cc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O10 compound treatment 258800.0 34900.0 0.93 192640.0 -23900.0 -0.61 0.228 0.2052 1064 SPBio_002848 [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O11 compound treatment 260520.0 36600.0 0.98 199920.0 -16600.0 -0.42 0.3914 0.3678 3189582 SPBio_002849 CC[C@H]1CN2CCC1C[C@H]2[C@H](O)c3ccnc4ccc(OC)cc34 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O12 compound treatment 245200.0 21300.0 0.57 237160.0 20600.0 0.52 0.7721 0.9992 1668673 SPBio_002850 Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O13 compound treatment 237360.0 13500.0 0.36 225240.0 8690.0 0.22 0.41 0.9728 824 SPBio_002851 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@@](O)(C(=O)OC)n4c5ccccc35 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O14 compound treatment 160000.0 -63900.0 -1.7 151880.0 -64700.0 -1.64 -2.3675 -0.9998 1467 SPBio_002852 CCCCOc1ccc(OCCCN2CCOCC2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O15 compound treatment 226320.0 2420.0 0.06 204600.0 -12000.0 -0.3 -0.1693 -0.5447 3069528 SPBio_002853 C/C=C\1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O16 compound treatment 264800.0 40900.0 1.09 171880.0 -44700.0 -1.14 -0.0321 -0.0204 3069574 SPBio_002854 CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O17 compound treatment 258560.0 34700.0 0.92 168600.0 -48000.0 -1.22 -0.2087 -0.1364 3187609 SPBio_002855 C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O18 compound treatment 230920.0 7020.0 0.19 155240.0 -61300.0 -1.56 -0.97 -0.6178 2081008 SPBio_002856 C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O19 compound treatment 285960.0 62100.0 1.65 194480.0 -22100.0 -0.56 0.7732 0.4425 3187610 SPBio_002857 CC[C@@H](C)C(=O)O[C@H]1[C@H](O)[C@H]2[C@@H](CN3C[C@@H](C)CC[C@H]3[C@@]2(C)O)C4C[C@]5(O[C@]6(O)[C@H]7[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@H]5[C@@]41O)[C@@]7(C)CC[C@@H]6OC(=O)C(C)(O)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O20 compound treatment 251560.0 27700.0 0.74 199200.0 -17400.0 -0.44 0.2095 0.2438 759 SPBio_002858 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O21 compound treatment 243720.0 19800.0 0.53 212480.0 -4070.0 -0.1 0.3005 0.5579 3069529 SPBio_002859 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]6(C[C@@H](O[C@@H]7OC(CO)[C@@H](O)[C@@H](O)C7O)[C@@H](O)C(CO)O6)O[C@H]8OC(C)[C@H](O)[C@H](O)C8O)N9C[C@@H](C)CC[C@H]19 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O22 compound treatment 245240.0 21300.0 0.57 222120.0 5570.0 0.14 0.5024 0.8569 3187749 SPBio_002860 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)N)\c3ccco3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O23 mock treatment 260440.0 36500.0 0.97 227320.0 10800.0 0.27 0.8825 0.872 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 O24 mock treatment 260400.0 36500.0 0.97 212760.0 -3790.0 -0.1 0.62 0.6339 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P01 mock treatment 197680.0 -26200.0 -0.7 209160.0 -7390.0 -0.19 -0.6272 -0.8665 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P02 mock treatment 263800.0 39900.0 1.06 207560.0 -8990.0 -0.23 0.5906 0.5427 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P03 compound treatment 222920.0 -978.0 -0.03 200000.0 -16600.0 -0.42 -0.3161 -0.7495 890 SPBio_002861 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P04 compound treatment 256280.0 32400.0 0.86 198320.0 -18200.0 -0.46 0.2827 0.2884 3069701 SPBio_002862 C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P05 compound treatment 258040.0 34100.0 0.91 181760.0 -34800.0 -0.88 0.0181 0.0143 244 SPBio_002863 CC[N+](C)(CC)CCC[n+]1c(c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P06 compound treatment 226160.0 2260.0 0.06 170480.0 -46100.0 -1.17 -0.7857 -0.6698 3487261 SPBio_002864 COCC(=O)Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)N(C)CC(O)CO)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P07 compound treatment 232880.0 8980.0 0.24 83960.0 -133000.0 -3.37 -2.2146 -0.6552 1431 SPBio_002865 Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P08 compound treatment 278840.0 54900.0 1.46 167480.0 -49100.0 -1.25 0.1535 0.0798 856 SPBio_002866 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P09 compound treatment 316640.0 92700.0 2.47 197080.0 -19500.0 -0.5 1.3984 0.5545 3187762 SPBio_002867 CC1CC(CC(C)(C)N1C)OC(=O)C(O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P10 compound treatment 255120.0 31200.0 0.83 177240.0 -39300.0 -1.0 -0.1182 -0.0909 1222 SPBio_002868 Cn1cnc2n(C)c(=O)[nH]c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P11 compound treatment 309800.0 85900.0 2.29 203800.0 -12800.0 -0.32 1.3902 0.601 3383 SPBio_002869 Cc1cc(no1)C(=O)NNCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P12 compound treatment 256040.0 32100.0 0.86 249800.0 33200.0 0.85 1.2037 1.0 687 SPBio_002870 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P13 compound treatment 219960.0 -3940.0 -0.11 169280.0 -47300.0 -1.2 -0.9242 -0.766 2105063 SPBio_002871 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P14 compound treatment 276760.0 52900.0 1.41 248880.0 32300.0 0.82 1.5778 0.967 989 SPBio_002872 NC(=N)NCCCCNC(=N)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P15 compound treatment 244720.0 20800.0 0.56 184520.0 -32000.0 -0.81 -0.1834 -0.1861 2752 SPBio_002873 COc1ccc2Sc3ccccc3N(C[C@H](C)CN(C)C)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P16 compound treatment 286920.0 63000.0 1.68 187280.0 -29300.0 -0.74 0.6618 0.3601 3060919 SPBio_002874 CN1C2CC(CC1C3OC32)OC(=O)[C@H](CO)c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P17 compound treatment 15640.0 -208000.0 -5.55 10800.0 -206000.0 -5.23 -7.6257 -0.9996 1370 SPBio_002875 C/C=C(/C(=C/C)/c1ccc(O)cc1)\c2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P18 compound treatment 293880.0 70000.0 1.87 168840.0 -47700.0 -1.21 0.4615 0.2074 3487262 SPBio_002876 OCCN(C(=O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P19 compound treatment 247280.0 23400.0 0.62 180840.0 -35700.0 -0.91 -0.2013 -0.1827 1328 SPBio_002877 OC(CCN1CCCCC1)(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P20 compound treatment 206000.0 -17900.0 -0.48 154120.0 -62400.0 -1.59 -1.46 -0.8807 446 SPBio_002878 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P21 compound treatment 266360.0 42500.0 1.13 237240.0 20700.0 0.53 1.1725 0.9392 794 SPBio_002879 Nc1cc(c[nH]c1=O)c2ccncc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P22 compound treatment 259520.0 35600.0 0.95 257960.0 41400.0 1.05 1.416 0.9987 1327 SPBio_002880 C[N+](C)(C)CCOC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P23 mock treatment 264080.0 40200.0 1.07 215360.0 -1190.0 -0.03 0.7361 0.6868 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2166 P24 mock treatment 222560.0 -1340.0 -0.04 193080.0 -23500.0 -0.6 -0.4473 -0.748 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A01 mock treatment 231320.0 11600.0 0.31 222800.0 11900.0 0.3 0.4317 0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A02 mock treatment 227240.0 7480.0 0.2 228960.0 18000.0 0.46 0.4655 0.9305 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A03 compound treatment 217360.0 -2400.0 -0.06 222280.0 11400.0 0.29 0.1591 0.5378 1300 SPBio_002881 OC(=O)c1cccnc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A04 compound treatment 200360.0 -19400.0 -0.52 214520.0 3600.0 0.09 -0.3009 -0.573 1073908 SPBio_002882 CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A05 compound treatment 211040.0 -8720.0 -0.23 235440.0 24500.0 0.62 0.2766 0.4156 2819 SPBio_002883 CCC1(C)CC(=O)NC(=O)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A06 compound treatment 198680.0 -21100.0 -0.56 233640.0 22700.0 0.58 0.0112 0.0139 1322 SPBio_002884 COc1cc2ccc(=O)oc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A07 compound treatment 16880.0 -203000.0 -5.41 31720.0 -179000.0 -4.56 -7.0467 -0.9964 3187897 SPBio_002885 C[C@]12[C@H](CC[C@]2(O)[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]1O)C5=CC(=O)OC5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A08 compound treatment 164440.0 -55300.0 -1.47 226240.0 15300.0 0.39 -0.7674 -0.5031 1081653 SPBio_002886 Clc1ccc(C(Cn2ccnc2)OCC=C)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A09 compound treatment 182720.0 -37000.0 -0.99 228240.0 17300.0 0.44 -0.3868 -0.3577 4370 SPBio_002887 CNCC(O)C(O)C(O)C(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A10 compound treatment 222160.0 2400.0 0.06 239320.0 28400.0 0.72 0.556 0.7669 1203 SPBio_002888 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A11 compound treatment 52960.0 -167000.0 -4.45 51960.0 -159000.0 -4.04 -6.0026 -0.9989 3172726 SPBio_002889 C[C@]12C3CCC(O3)[C@]2(C)C(=O)OC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A12 compound treatment 216480.0 -3280.0 -0.09 234880.0 24000.0 0.61 0.3691 0.5996 2060138 SPBio_002890 C[C@]1([C@H]2[C@H](C(=O)O)[C@]3(CC(=C)[C@@]4(O)C3)[C@@H](CC4)[C@]52OC1=O)[C@@H](O)C=C5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A13 compound treatment 12400.0 -207000.0 -5.53 14440.0 -196000.0 -5.0 -7.4419 -0.9987 1999 SPBio_002891 Oc1c(I)cc(Cl)c2cccnc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A14 compound treatment 214320.0 -5440.0 -0.14 240760.0 29800.0 0.76 0.4341 0.5619 3480627 SPBio_002892 CC(C)NCC(O)c1ccc(NS(=O)(=O)C)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A15 compound treatment 217280.0 -2480.0 -0.07 210600.0 -318.0 -0.01 -0.0524 -0.7878 838 SPBio_002893 COc1ccc(C(=O)c2ccccc2)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A16 compound treatment 214680.0 -5080.0 -0.14 15080.0 -196000.0 -4.98 -3.6167 -0.7261 3188025 SPBio_002894 CN1C2CC(O)C1CC(=O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A17 compound treatment 205000.0 -14800.0 -0.39 191760.0 -19200.0 -0.49 -0.6226 -0.9944 681 SPBio_002895 CC(CN1c2ccccc2Sc3ccccc13)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A18 compound treatment 204000.0 -15800.0 -0.42 239240.0 28300.0 0.72 0.2122 0.2545 3855 SPBio_002896 C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A19 compound treatment 177840.0 -41900.0 -1.12 249120.0 38200.0 0.97 -0.1034 -0.0698 1225 SPBio_002897 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A20 compound treatment 211120.0 -8640.0 -0.23 211600.0 682.0 0.02 -0.1505 -0.652 1040327 SPBio_002898 CC(=O)Nc1cc2ccccc2oc1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A21 compound treatment 211040.0 -8720.0 -0.23 233400.0 22500.0 0.57 0.2399 0.3888 3487233 SPBio_002899 CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A22 compound treatment 217240.0 -2520.0 -0.07 247960.0 37000.0 0.94 0.6186 0.6551 1120 SPBio_002900 Oc1ccc(cc1[N+](=O)[O-])[As](=O)(O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A23 mock treatment 226440.0 6680.0 0.18 225800.0 14900.0 0.38 0.3936 0.941 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 A24 mock treatment 235240.0 15500.0 0.41 191440.0 -19500.0 -0.5 -0.0583 -0.0904 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B01 mock treatment 243920.0 24200.0 0.64 225280.0 14400.0 0.37 0.7138 0.9638 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B02 mock treatment 212480.0 -7280.0 -0.19 222160.0 11200.0 0.29 0.065 0.188 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B03 compound treatment 209080.0 -10700.0 -0.28 236600.0 25700.0 0.65 0.2605 0.3657 3069812 SPBio_002901 CCOC(=O)c1cncn1C(C)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B04 mock treatment 229120.0 9360.0 0.25 224800.0 13900.0 0.35 0.4261 0.9856 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B05 compound treatment 199880.0 -19900.0 -0.53 226440.0 15500.0 0.39 -0.0956 -0.1447 3188157 SPBio_002902 CC[N+](CC)(CC)CCC(O)(C1CCCCC1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B06 mock treatment 207240.0 -12500.0 -0.33 230640.0 19700.0 0.5 0.1186 0.1969 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B07 compound treatment 186840.0 -32900.0 -0.88 200000.0 -10900.0 -0.28 -0.8169 -0.8874 3487585 SPBio_002903 CC(C)(C)NCC(O)COc1ccccc1C2CCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B08 mock treatment 196440.0 -23300.0 -0.62 208840.0 -2080.0 -0.05 -0.4769 -0.7645 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B09 compound treatment 197880.0 -21900.0 -0.58 233520.0 22600.0 0.57 -0.0061 -0.0074 3188158 SPBio_002904 CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C)C(=O)COC(=O)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B10 mock treatment 204880.0 -14900.0 -0.4 223000.0 12100.0 0.31 -0.0632 -0.126 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B11 compound treatment 14600.0 -205000.0 -5.47 17440.0 -193000.0 -4.92 -7.3464 -0.9986 3069813 SPBio_002905 Clc1ccc(C(Cn2ccnc2)OCc3csc4c(Cl)cccc34)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B12 mock treatment 219400.0 -355.0 -0.01 214360.0 3440.0 0.09 0.0552 0.6269 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B13 compound treatment 163400.0 -56400.0 -1.5 163640.0 -47300.0 -1.2 -1.9125 -0.9939 3188159 SPBio_002906 CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B14 mock treatment 220000.0 245.0 0.01 234240.0 23300.0 0.59 0.4239 0.7148 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B15 compound treatment 226520.0 6760.0 0.18 219960.0 9040.0 0.23 0.2901 0.9928 3168 SPBio_002907 NS(=O)(=O)c1cc(cc(N2CCCC2)c1Oc3ccccc3)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B16 mock treatment 184000.0 -35800.0 -0.95 218880.0 7960.0 0.2 -0.531 -0.5448 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B17 compound treatment 175320.0 -44400.0 -1.18 222040.0 11100.0 0.28 -0.6378 -0.5236 3188160 SPBio_002908 CC(=O)c1ccc2Sc3ccccc3N(CCCN4CCC(CCO)CC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B18 mock treatment 201760.0 -18000.0 -0.48 225920.0 15000.0 0.38 -0.0695 -0.1135 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B19 compound treatment 57160.0 -163000.0 -4.34 142600.0 -68300.0 -1.74 -4.2938 -0.9194 943 SPBio_002909 CCCCC1C(=O)N(N(C1=O)c2ccc(O)cc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B20 mock treatment 224280.0 4520.0 0.12 241000.0 30100.0 0.76 0.6262 0.8086 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B21 compound treatment 225800.0 6040.0 0.16 244920.0 34000.0 0.86 0.7253 0.8247 3069814 SPBio_002910 CCC1NC(=O)c2cc(c(Cl)cc2N1)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B22 mock treatment 229160.0 9400.0 0.25 227040.0 16100.0 0.41 0.4672 0.9722 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B23 mock treatment 241240.0 21500.0 0.57 225080.0 14200.0 0.36 0.6597 0.975 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 B24 mock treatment 251600.0 31800.0 0.85 224480.0 13600.0 0.34 0.8442 0.9212 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C01 mock treatment 227520.0 7760.0 0.21 224840.0 13900.0 0.35 0.3967 0.9674 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C02 mock treatment 214360.0 -5400.0 -0.14 214560.0 3640.0 0.09 -0.0362 -0.2118 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C03 compound treatment 192040.0 -27700.0 -0.74 204440.0 -6480.0 -0.16 -0.639 -0.844 1022907 SPBio_002911 CC(=O)c1cc2ccccc2oc1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C04 compound treatment 201120.0 -18600.0 -0.5 210680.0 -238.0 -0.01 -0.3556 -0.7157 3188026 SPBio_002912 CCN1CCC[C@H]1CNC(=O)c2c(OC)ccc(Br)c2OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C05 compound treatment 197400.0 -22400.0 -0.6 216760.0 5840.0 0.15 -0.3164 -0.5151 3187898 SPBio_002913 OCC1O[C@@H](Oc2cc3ccc(=O)oc3cc2O)C(O)[C@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C06 compound treatment 211680.0 -8080.0 -0.22 230000.0 19100.0 0.49 0.1908 0.3595 864 SPBio_002914 Oc1noc2CNCCc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C07 compound treatment 186280.0 -33500.0 -0.89 211360.0 442.0 0.01 -0.6232 -0.6981 2776 SPBio_002915 OC(=O)Cc1ccc(cc1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C08 compound treatment 191400.0 -28400.0 -0.76 207840.0 -3080.0 -0.08 -0.5899 -0.7762 1134931 SPBio_002916 Cc1ccc2n3CCNC4CCCc(c43)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C09 compound treatment 178040.0 -41700.0 -1.11 216160.0 5240.0 0.13 -0.6922 -0.6179 1012530 SPBio_002917 CCCCOC(=O)c1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C10 compound treatment 188680.0 -31100.0 -0.83 214160.0 3240.0 0.08 -0.5276 -0.6336 1512 SPBio_002918 CC(C)NCC(O)c1ccc2ccccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C11 compound treatment 190160.0 -29600.0 -0.79 198640.0 -12300.0 -0.31 -0.7787 -0.9177 1299 SPBio_002919 Nc1ccc(cc1)C(=O)NCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C12 compound treatment 178920.0 -40800.0 -1.09 194040.0 -16900.0 -0.43 -1.0733 -0.9171 3480607 SPBio_002920 COc1ccccc1N2CCN(CC(O)COc3cccc4ccccc34)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C13 compound treatment 213480.0 -6280.0 -0.17 201560.0 -9360.0 -0.24 -0.2866 -0.9852 1231 SPBio_002921 CC(C)C[C@H](NC(=O)C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C14 compound treatment 177720.0 -42000.0 -1.12 227240.0 16300.0 0.42 -0.499 -0.4176 907524 SPBio_002922 CCCCNc1c(C(=O)OCC)c(C)nc2n(CC)ncc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C15 compound treatment 197480.0 -22300.0 -0.59 210080.0 -838.0 -0.02 -0.435 -0.732 1258 SPBio_002923 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCNCC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C16 compound treatment 204880.0 -14900.0 -0.4 233480.0 22600.0 0.57 0.1252 0.1795 2372 SPBio_002924 COc1cc(ccc1OC(F)F)c2ccc(=O)[nH]n2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C17 compound treatment 182160.0 -37600.0 -1.0 214000.0 3080.0 0.08 -0.6534 -0.6498 3059213 SPBio_002925 COc1ccc(C(=O)c2ccccc2O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C18 compound treatment 190760.0 -29000.0 -0.77 211760.0 842.0 0.02 -0.5315 -0.6873 733 SPBio_002926 CC1(CC2CC3(C)C1)CC(N)(C2)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C19 compound treatment 119440.0 -100000.0 -2.67 154720.0 -56200.0 -1.43 -2.9017 -0.9569 3187899 SPBio_002927 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C20 compound treatment 193000.0 -26800.0 -0.71 213040.0 2120.0 0.05 -0.4663 -0.6518 2742 SPBio_002928 OC(=O)/C=C/c1ccc(Cn2ccnc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C21 compound treatment 203280.0 -16500.0 -0.44 210960.0 42.0 0.0 -0.3099 -0.7054 1019709 SPBio_002929 C[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C22 compound treatment 202000.0 -17800.0 -0.47 190840.0 -20100.0 -0.51 -0.6957 -0.9993 2245 SPBio_002930 C(N1CCN(CC1)c2ncccn2)c3ccc4OCOc4c3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C23 mock treatment 204800.0 -15000.0 -0.4 198800.0 -12100.0 -0.31 -0.4998 -0.9919 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 C24 mock treatment 229680.0 9920.0 0.26 183920.0 -27000.0 -0.69 -0.2983 -0.4055 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D01 mock treatment 220400.0 645.0 0.02 222880.0 12000.0 0.3 0.2272 0.7459 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D02 mock treatment 201960.0 -17800.0 -0.47 212680.0 1760.0 0.04 -0.3038 -0.6375 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D03 compound treatment 193120.0 -26600.0 -0.71 221120.0 10200.0 0.26 -0.3187 -0.4216 1267101 SPBio_002931 CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN4CCOCC4)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D04 mock treatment 207880.0 -11900.0 -0.32 225320.0 14400.0 0.37 0.035 0.0724 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D05 compound treatment 208120.0 -11600.0 -0.31 227520.0 16600.0 0.42 0.0791 0.151 1487 SPBio_002932 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D06 mock treatment 207160.0 -12600.0 -0.34 231400.0 20500.0 0.52 0.1308 0.2111 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D07 compound treatment 207720.0 -12000.0 -0.32 216560.0 5640.0 0.14 -0.1255 -0.3569 3188161 SPBio_002933 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](/N=C/N3CCCCCC3)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D08 mock treatment 207560.0 -12200.0 -0.33 227040.0 16100.0 0.41 0.0599 0.1146 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D09 compound treatment 190360.0 -29400.0 -0.78 206120.0 -4800.0 -0.12 -0.6405 -0.8074 3188162 SPBio_002934 CCC(=O)OC(Cc1ccccc1)(C(C)CN(C)C)c2ccccc2.OS(=O)(=O)c1ccc2ccccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D10 mock treatment 198560.0 -21200.0 -0.57 208120.0 -2800.0 -0.07 -0.4499 -0.7899 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D11 compound treatment 200240.0 -19500.0 -0.52 204120.0 -6800.0 -0.17 -0.4902 -0.894 772 SPBio_002935 CCN1CCCC(C1)OC(=O)C(c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D12 mock treatment 209760.0 -10000.0 -0.27 215720.0 4800.0 0.12 -0.1021 -0.3483 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D13 compound treatment 148680.0 -71100.0 -1.9 128040.0 -82900.0 -2.11 -2.8301 -0.9986 3069815 SPBio_002936 OC[C@H]1O[C@H](C[C@H]1O)n2cc(c(=O)[nH]c2=O)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D14 mock treatment 201000.0 -18800.0 -0.5 214400.0 3480.0 0.09 -0.291 -0.573 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D15 compound treatment 203400.0 -16400.0 -0.44 204080.0 -6840.0 -0.17 -0.4313 -0.9187 1001977 SPBio_002937 CC(C)NCC(O)COc1ccccc1OCC=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D16 mock treatment 206200.0 -13600.0 -0.36 208520.0 -2400.0 -0.06 -0.2987 -0.8149 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D17 compound treatment 178240.0 -41500.0 -1.11 198800.0 -12100.0 -0.31 -1.0006 -0.8708 1434439 SPBio_002938 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D18 mock treatment 210160.0 -9600.0 -0.26 213520.0 2600.0 0.07 -0.1341 -0.5076 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D19 compound treatment 195880.0 -23900.0 -0.64 210080.0 -838.0 -0.02 -0.4652 -0.7304 3069816 SPBio_002939 CCCOc1cc(N)ccc1C(=O)OCCN(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D20 mock treatment 204640.0 -15100.0 -0.4 233520.0 22600.0 0.57 0.1214 0.1729 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D21 compound treatment 193120.0 -26600.0 -0.71 218360.0 7440.0 0.19 -0.3684 -0.5012 1672 SPBio_002940 OC(=O)CCc1nc(c(o1)c2ccccc2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D22 mock treatment 210600.0 -9160.0 -0.24 205200.0 -5720.0 -0.15 -0.2754 -0.9694 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D23 mock treatment 200840.0 -18900.0 -0.5 208760.0 -2160.0 -0.05 -0.3954 -0.7794 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 D24 mock treatment 214040.0 -5720.0 -0.15 171080.0 -39800.0 -1.01 -0.824 -0.8044 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E01 mock treatment 207680.0 -12100.0 -0.32 270800.0 59900.0 1.52 0.849 0.5455 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E02 mock treatment 191840.0 -27900.0 -0.74 244520.0 33600.0 0.85 0.0778 0.0687 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E03 compound treatment 206080.0 -13700.0 -0.36 264040.0 53100.0 1.35 0.6973 0.4984 2732 SPBio_002941 Cc1cc(=O)oc2cc(O)ccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E04 compound treatment 197360.0 -22400.0 -0.6 217600.0 6680.0 0.17 -0.3021 -0.4866 3188027 SPBio_002942 CCN(CC)CCOC(=O)C1(CCCC1)c2ccc(cc2)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E05 compound treatment 209040.0 -10700.0 -0.29 229040.0 18100.0 0.46 0.1238 0.2283 1978 SPBio_002943 OC(=O)/C=C/c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E06 compound treatment 233320.0 13600.0 0.36 274920.0 64000.0 1.63 1.4064 0.8437 2098610 SPBio_002944 C1CC1C(NC2=NCCO2)C3CC3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E07 compound treatment 207040.0 -12700.0 -0.34 228080.0 17200.0 0.44 0.0688 0.1246 3069737 SPBio_002945 CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E08 compound treatment 204440.0 -15300.0 -0.41 212560.0 1640.0 0.04 -0.2592 -0.6315 3723 SPBio_002946 CN(C)CCCSC(=N)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E09 compound treatment 223440.0 3680.0 0.1 199680.0 -11200.0 -0.29 -0.1326 -0.4388 2743 SPBio_002947 CC(C)(C(=O)c1cccnc1)c2cccnc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E10 compound treatment 230560.0 10800.0 0.29 224600.0 13700.0 0.35 0.4497 0.9956 3069774 SPBio_002948 CO[C@H]1[C@H](O)C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E11 compound treatment 227520.0 7760.0 0.21 212400.0 1480.0 0.04 0.173 0.8223 3202 SPBio_002949 COc1ccccc1N2CCN(CCCNc3cc(=O)n(C)c(=O)n3C)CC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E12 compound treatment 207200.0 -12600.0 -0.33 218480.0 7560.0 0.19 -0.1008 -0.261 3069775 SPBio_002950 CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E13 compound treatment 39040.0 -181000.0 -4.82 39920.0 -171000.0 -4.35 -6.4815 -0.9987 23081 SPBio_002951 Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E14 compound treatment 25600.0 -194000.0 -5.18 32600.0 -178000.0 -4.53 -6.8665 -0.9978 3188028 SPBio_002952 CC1O[C@@H](O[C@H]2CC[C@]3(C)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CCC3=C2)c6ccc(=O)oc6)C(O)[C@@H](O)[C@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E15 compound treatment 206720.0 -13000.0 -0.35 207160.0 -3760.0 -0.1 -0.3133 -0.8693 1472 SPBio_002953 CC(C)Cc1ccc(cc1)[C@H](C)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E16 compound treatment 17040.0 -203000.0 -5.4 20440.0 -190000.0 -4.84 -7.2465 -0.9985 2549 SPBio_002954 C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E17 compound treatment 181600.0 -38200.0 -1.02 211680.0 762.0 0.02 -0.7057 -0.6935 3187900 SPBio_002955 CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(OC(=O)C)C#C)[C@@H]3CCC2=C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E18 compound treatment 199240.0 -20500.0 -0.55 221400.0 10500.0 0.27 -0.1983 -0.3259 3069776 SPBio_002956 C[C@]1(C[C@H](O)[C@@]2(O)C=CO[C@H](OC3OC(CO)C(O)C(O)C3O)C12)OC(=O)/C=C\c4ccccc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E19 compound treatment 195960.0 -23800.0 -0.63 221360.0 10400.0 0.27 -0.2609 -0.3793 1440 SPBio_002957 COc1ccc2cc(CCC(=O)C)ccc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E20 compound treatment 201440.0 -18300.0 -0.49 241840.0 30900.0 0.79 0.2106 0.2276 3188029 SPBio_002958 C[C@@H]1CCC2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)C5CC[C@]43C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6OC(CO[C@@H]7OC(CO)[C@@H](O[C@@H]8OC(C)[C@H](O)[C@H](O)C8O)[C@@H](O)C7O)[C@@H](O)[C@@H](O)C6O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E21 compound treatment 202720.0 -17000.0 -0.45 232160.0 21200.0 0.54 0.0607 0.0861 907434 SPBio_002959 CNCCC(Oc1ccccc1OC)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E22 compound treatment 203880.0 -15900.0 -0.42 224560.0 13600.0 0.35 -0.054 -0.0987 3069777 SPBio_002960 CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E23 mock treatment 200520.0 -19200.0 -0.51 205760.0 -5160.0 -0.13 -0.4554 -0.8602 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 E24 mock treatment 207640.0 -12100.0 -0.32 186280.0 -24600.0 -0.63 -0.6714 -0.9525 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F01 mock treatment 207760.0 -12000.0 -0.32 261440.0 50500.0 1.28 0.6822 0.5153 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F02 mock treatment 201440.0 -18300.0 -0.49 225800.0 14900.0 0.38 -0.0777 -0.1258 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F03 compound treatment 201680.0 -18100.0 -0.48 241320.0 30400.0 0.77 0.2058 0.2259 3188163 SPBio_002961 CN1C(=O)CC(C1=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F04 mock treatment 207920.0 -11800.0 -0.32 218600.0 7680.0 0.2 -0.085 -0.2291 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F05 compound treatment 204520.0 -15200.0 -0.41 249960.0 39000.0 0.99 0.4147 0.3866 2957 SPBio_002962 CNC(=O)c1c(I)c(N(C)C(=O)C)c(I)c(C(=O)NCC(=O)Nc2c(I)c(C(=O)O)c(I)c(C(=O)NCCO)c2I)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F06 mock treatment 197240.0 -22500.0 -0.6 224400.0 13500.0 0.34 -0.1821 -0.2634 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F07 compound treatment 172280.0 -47500.0 -1.27 207520.0 -3400.0 -0.09 -0.9562 -0.7536 3069817 SPBio_002963 CN(C/C=C/c1ccccc1)Cc2cccc3ccccc23 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F08 mock treatment 226680.0 6920.0 0.18 227240.0 16300.0 0.42 0.424 0.9335 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F09 compound treatment 233040.0 13300.0 0.35 208760.0 -2160.0 -0.05 0.2117 0.5905 907413 SPBio_002964 CCCNC(C)(C)COC(=O)c1ccccc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F10 mock treatment 213960.0 -5800.0 -0.15 224680.0 13800.0 0.35 0.1382 0.3612 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F11 compound treatment 222520.0 2760.0 0.07 224960.0 14000.0 0.36 0.3046 0.8355 1666 SPBio_002965 Cc1[nH]c(=O)c(C#N)cc1c2ccncc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F12 mock treatment 232600.0 12800.0 0.34 215840.0 4920.0 0.13 0.3307 0.9069 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F13 compound treatment 226960.0 7200.0 0.19 249520.0 38600.0 0.98 0.8299 0.8298 4382 SPBio_002966 CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F14 mock treatment 230120.0 10400.0 0.28 212960.0 2040.0 0.05 0.2321 0.8255 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F15 compound treatment 228520.0 8760.0 0.23 230640.0 19700.0 0.5 0.5198 0.9396 2586 SPBio_002967 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C(=O)O)c3ccsc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F16 mock treatment 207640.0 -12100.0 -0.32 215800.0 4880.0 0.12 -0.1406 -0.4064 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F17 compound treatment 197000.0 -22800.0 -0.61 218920.0 8000.0 0.2 -0.2851 -0.4456 3188276 SPBio_002968 CCSc1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1.OC(CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F18 mock treatment 213640.0 -6120.0 -0.16 208240.0 -2680.0 -0.07 -0.1634 -0.925 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F19 compound treatment 224800.0 5040.0 0.13 229040.0 18100.0 0.46 0.4209 0.8769 1778 SPBio_002969 Nc1ccc(O)c(c1)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F20 mock treatment 202320.0 -17400.0 -0.46 217840.0 6920.0 0.18 -0.2043 -0.4109 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F21 compound treatment 205480.0 -14300.0 -0.38 220120.0 9200.0 0.23 -0.1037 -0.2321 3047 SPBio_002970 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(=C3[C@H]2OC1=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F22 mock treatment 227200.0 7440.0 0.2 217960.0 7040.0 0.18 0.267 0.9987 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F23 mock treatment 199360.0 -20400.0 -0.54 219320.0 8400.0 0.21 -0.2335 -0.3996 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 F24 mock treatment 206440.0 -13300.0 -0.36 132080.0 -78800.0 -2.0 -1.6685 -0.8196 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G01 mock treatment 211320.0 -8440.0 -0.22 228520.0 17600.0 0.45 0.1574 0.3143 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G02 mock treatment 218760.0 -995.0 -0.03 218360.0 7440.0 0.19 0.115 0.602 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G03 compound treatment 196080.0 -23700.0 -0.63 226120.0 15200.0 0.39 -0.173 -0.2338 3069738 SPBio_002971 CC(C)NCC(O)c1ccc(O)c(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G04 compound treatment 217560.0 -2200.0 -0.06 244680.0 33800.0 0.86 0.5656 0.6574 1327636 SPBio_002972 COc1ccc2c(c1)C(=O)N(CCc3ccc(cc3)S(=O)(=O)NC(=O)NC4CCCCC4)C(=O)C2(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G05 compound treatment 72840.0 -147000.0 -3.92 72080.0 -139000.0 -3.53 -5.266 -0.9987 1001471 SPBio_002973 Oc1ccc(OCc2ccccc2)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G06 compound treatment 212360.0 -7400.0 -0.2 240720.0 29800.0 0.76 0.3964 0.5062 3069778 SPBio_002974 CN1CCC(=C2c3ccsc3CCc4ccccc24)CC1.OC(CC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G07 compound treatment 214000.0 -5760.0 -0.15 212120.0 1200.0 0.03 -0.0869 -0.5554 1025776 SPBio_002975 Nc1ccccc1S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G08 compound treatment 234680.0 14900.0 0.4 259120.0 48200.0 1.23 1.148 0.8909 3188030 SPBio_002976 NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@H](O)C2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G09 compound treatment 207160.0 -12600.0 -0.34 213840.0 2920.0 0.07 -0.1849 -0.5377 3060043 SPBio_002977 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2CCC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G10 compound treatment 213120.0 -6640.0 -0.18 215320.0 4400.0 0.11 -0.046 -0.2195 1057366 SPBio_002978 NS(=O)(=O)c1cc2c(NC(CC3CCCC3)NS2(=O)=O)cc1Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G11 compound treatment 197320.0 -22400.0 -0.6 196800.0 -14100.0 -0.36 -0.6768 -0.9702 907370 SPBio_002979 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G12 compound treatment 210520.0 -9240.0 -0.25 207200.0 -3720.0 -0.09 -0.241 -0.9136 3177109 SPBio_002980 COCCCC/C(=N\OCCN)/c1ccc(cc1)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G13 compound treatment 226400.0 6640.0 0.18 201640.0 -9280.0 -0.24 -0.0415 -0.1408 117 SPBio_002981 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G14 compound treatment 247520.0 27800.0 0.74 209320.0 -1600.0 -0.04 0.4947 0.6673 3069779 SPBio_002982 NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4cccs4)C3=O)C(=O)O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G15 compound treatment 220080.0 325.0 0.01 221240.0 10300.0 0.26 0.1917 0.73 1000135 SPBio_002983 CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G16 compound treatment 209680.0 -10100.0 -0.27 209040.0 -1880.0 -0.05 -0.2237 -0.8199 1000221 SPBio_002984 CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)SCF 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G17 compound treatment 211160.0 -8600.0 -0.23 205240.0 -5680.0 -0.14 -0.2641 -0.9752 115 SPBio_002985 COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G18 compound treatment 148200.0 -71600.0 -1.91 196320.0 -14600.0 -0.37 -1.6115 -0.8291 3069780 SPBio_002986 OCCN1CCN(CC/C=C\2/c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G19 compound treatment 227960.0 8200.0 0.22 246880.0 36000.0 0.91 0.8013 0.8522 3221506 SPBio_002987 CCC(C)C(N)C1=NC(CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G20 compound treatment 207160.0 -12600.0 -0.34 240440.0 29500.0 0.75 0.2933 0.3567 4480 SPBio_002988 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G21 compound treatment 206680.0 -13100.0 -0.35 242080.0 31200.0 0.79 0.3138 0.3625 1008 SPBio_002989 OC1CCCCC1N2CCC(CC2)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G22 compound treatment 209120.0 -10600.0 -0.28 217240.0 6320.0 0.16 -0.0868 -0.2664 3188032 SPBio_002990 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCNC(CCCCN)C(=O)O)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G23 mock treatment 200960.0 -18800.0 -0.5 217600.0 6680.0 0.17 -0.2342 -0.4426 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 G24 mock treatment 216200.0 -3560.0 -0.09 78240.0 -133000.0 -3.37 -2.4525 -0.7267 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H01 mock treatment 229360.0 9600.0 0.26 217160.0 6240.0 0.16 0.2933 0.9735 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H02 mock treatment 230800.0 11000.0 0.29 222880.0 12000.0 0.3 0.4233 0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H03 compound treatment 219960.0 205.0 0.01 217640.0 6720.0 0.17 0.1247 0.7293 3069853 SPBio_002991 OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H04 mock treatment 211240.0 -8520.0 -0.23 231200.0 20300.0 0.52 0.2041 0.3622 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H05 compound treatment 214640.0 -5120.0 -0.14 234080.0 23200.0 0.59 0.32 0.5293 1503 SPBio_002992 Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H06 mock treatment 220560.0 805.0 0.02 233560.0 22600.0 0.58 0.4223 0.7329 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H07 compound treatment 220520.0 765.0 0.02 238840.0 27900.0 0.71 0.5164 0.7271 834 SPBio_002993 CC(C[N+](C)(C)C)OC(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H08 mock treatment 216520.0 -3240.0 -0.09 207600.0 -3320.0 -0.08 -0.1207 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H09 compound treatment 230720.0 11000.0 0.29 236480.0 25600.0 0.65 0.6663 0.9349 3188277 SPBio_002994 CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)C5CC5[C@]4(C)[C@H]3CC[C@@]21C)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H10 mock treatment 251400.0 31600.0 0.84 221080.0 10200.0 0.26 0.7793 0.8832 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H11 compound treatment 266760.0 47000.0 1.25 216000.0 5080.0 0.13 0.9776 0.7759 1000206 SPBio_002995 CC(C)NC[C@@H](O)COc1cccc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H12 mock treatment 227720.0 7960.0 0.21 226680.0 15800.0 0.4 0.4335 0.9559 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H13 compound treatment 260440.0 40700.0 1.08 222440.0 11500.0 0.29 0.9742 0.867 3903 SPBio_002996 CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H14 mock treatment 224320.0 4560.0 0.12 220200.0 9280.0 0.24 0.2529 0.9525 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H15 compound treatment 230520.0 10800.0 0.29 240720.0 29800.0 0.76 0.7388 0.9117 1029881 SPBio_002997 CN1C2CCC1CC(O)C2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H16 mock treatment 228800.0 9040.0 0.24 215160.0 4240.0 0.11 0.2468 0.9342 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H17 compound treatment 219680.0 -75.4 0.0 233920.0 23000.0 0.58 0.4121 0.7047 954 SPBio_002998 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H18 mock treatment 208120.0 -11600.0 -0.31 216160.0 5240.0 0.13 -0.1251 -0.3706 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H19 compound treatment 202480.0 -17300.0 -0.46 233240.0 22300.0 0.57 0.0756 0.1035 1295 SPBio_002999 OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H20 mock treatment 208840.0 -10900.0 -0.29 198080.0 -12800.0 -0.33 -0.4366 -0.9984 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H21 compound treatment 145320.0 -74400.0 -1.98 161960.0 -49000.0 -1.24 -2.2836 -0.9748 3188278 SPBio_003000 COC(=O)Nc1nc2cc(SC(C)C)ccc2[nH]1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H22 mock treatment 206640.0 -13100.0 -0.35 214520.0 3600.0 0.09 -0.1825 -0.5049 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H23 mock treatment 201680.0 -18100.0 -0.48 211600.0 682.0 0.02 -0.3285 -0.6812 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 H24 mock treatment 214080.0 -5680.0 -0.15 131400.0 -79500.0 -2.02 -1.5367 -0.7579 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I01 mock treatment 229000.0 9240.0 0.25 199360.0 -11600.0 -0.29 -0.0335 -0.0874 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I02 mock treatment 227800.0 8040.0 0.21 212320.0 1400.0 0.04 0.1769 0.8135 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I03 compound treatment 200760.0 -19000.0 -0.51 214840.0 3920.0 0.1 -0.2876 -0.5572 3188016 SPBio_003001 CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(CN(C)C)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I04 compound treatment 200360.0 -19400.0 -0.52 211240.0 322.0 0.01 -0.3599 -0.6958 3069781 SPBio_003002 CC(=O)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I05 compound treatment 187120.0 -32600.0 -0.87 217000.0 6080.0 0.15 -0.5059 -0.5725 3188017 SPBio_003003 S=C(NC1CCCCC1)N2CCC(CC2)C3C=NC=N3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I06 compound treatment 192320.0 -27400.0 -0.73 216680.0 5760.0 0.15 -0.4137 -0.5545 3177333 SPBio_003004 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I07 compound treatment 213280.0 -6480.0 -0.17 210440.0 -478.0 -0.01 -0.1307 -0.755 3061617 SPBio_003005 OC(CNCCNC(=O)N1CCOCC1)COc2ccc(O)cc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I08 compound treatment 222640.0 2880.0 0.08 244120.0 33200.0 0.84 0.6513 0.7683 1053328 SPBio_003006 CCCC1C(=O)N2N(C1=O)c3cc(C)ccc3N=C2N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I09 compound treatment 228960.0 9200.0 0.25 224520.0 13600.0 0.35 0.4181 0.9859 1000092 SPBio_003007 COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I10 compound treatment 212800.0 -6960.0 -0.19 211760.0 842.0 0.02 -0.116 -0.6213 3188033 SPBio_003008 CCC1(CCCCN(C)C1)c2cccc(O)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I11 compound treatment 23360.0 -196000.0 -5.24 29360.0 -182000.0 -4.62 -6.967 -0.998 1007994 SPBio_003009 CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I12 compound treatment 216360.0 -3400.0 -0.09 216720.0 5800.0 0.15 0.0403 0.2328 3188034 SPBio_003010 CNC1C(O)C2O[C@H](OC3C(N)C[C@@H](N)C(O)[C@H]3O)C(N)C[C@@H]2O[C@@H]1O[C@H]4OC(CO)[C@@H](N)[C@H](O)C4O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I13 compound treatment 213120.0 -6640.0 -0.18 211880.0 962.0 0.02 -0.1078 -0.6036 3060036 SPBio_003011 C1CN=C(N1)C2COc3ccccc3O2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I14 compound treatment 212920.0 -6840.0 -0.18 204120.0 -6800.0 -0.17 -0.2511 -0.9996 3069782 SPBio_003012 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4CC5SC5C[C@@]43C)[C@@H]2CC[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I15 compound treatment 219160.0 -595.0 -0.02 213080.0 2160.0 0.05 0.0276 0.4832 3188018 SPBio_003013 CCN(CC)C(=O)N[C@@H]1CC2C(Cc3c[nH]c4cccc2c34)N(C)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I16 compound treatment 205360.0 -14400.0 -0.38 212320.0 1400.0 0.04 -0.2462 -0.6387 3188035 SPBio_003014 C/C(=C(/CCO)\SSCC1CCCO1)/N(Cc2cnc(C)nc2N)C=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I17 compound treatment 212600.0 -7160.0 -0.19 214160.0 3240.0 0.08 -0.0766 -0.3686 1765 SPBio_003015 CC1(C)NC(=O)N(C1=O)c2ccc([N+](=O)[O-])c(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I18 compound treatment 215360.0 -4400.0 -0.12 200880.0 -10000.0 -0.26 -0.2633 -0.9377 2080 SPBio_003016 CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I19 compound treatment 207320.0 -12400.0 -0.33 195120.0 -15800.0 -0.4 -0.5185 -0.9955 3172846 SPBio_003017 NC(CO)(CO)CO.OC(=O)C1CCn2c(ccc12)C(=O)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I20 compound treatment 206920.0 -12800.0 -0.34 207320.0 -3600.0 -0.09 -0.3067 -0.8657 3188145 SPBio_003018 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I21 compound treatment 204320.0 -15400.0 -0.41 204520.0 -6400.0 -0.16 -0.406 -0.9175 4487 SPBio_003019 CNCCCC1c2ccccc2C=Cc3ccccc13 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I22 compound treatment 193480.0 -26300.0 -0.7 216000.0 5080.0 0.13 -0.404 -0.5671 3188146 SPBio_003020 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)OC4OC(=O)c5ccccc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I23 mock treatment 207280.0 -12500.0 -0.33 223080.0 12200.0 0.31 -0.0165 -0.0364 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 I24 mock treatment 216720.0 -3040.0 -0.08 152920.0 -58000.0 -1.47 -1.1 -0.7448 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J01 mock treatment 222200.0 2440.0 0.07 202600.0 -8320.0 -0.21 -0.1035 -0.4675 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J02 mock treatment 213400.0 -6360.0 -0.17 217360.0 6440.0 0.16 -0.004 -0.017 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J03 compound treatment 194560.0 -25200.0 -0.67 223440.0 12500.0 0.32 -0.2499 -0.3361 3002368 SPBio_003021 CC(C)NC[C@H](O)COc1cccc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J04 mock treatment 207280.0 -12500.0 -0.33 212520.0 1600.0 0.04 -0.2064 -0.6159 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J05 compound treatment 181000.0 -38800.0 -1.03 191240.0 -19700.0 -0.5 -1.0845 -0.9446 907302 SPBio_003022 CN1CC[C@]2(C)C1N(C)c3ccc(O)cc32 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J06 mock treatment 229880.0 10100.0 0.27 220320.0 9400.0 0.24 0.3599 0.9982 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J07 compound treatment 207600.0 -12200.0 -0.32 210240.0 -678.0 -0.02 -0.2414 -0.7437 3188279 SPBio_003023 CCN1C[C@]2(COC)CC[C@H](O)C3(C4C[C@H]5[C@H](OC(=O)C)C4[C@](O)(CC5OC)[C@H]6CC32)[C@@H]61 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J08 mock treatment 220720.0 965.0 0.03 213080.0 2160.0 0.05 0.0571 0.9401 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J09 compound treatment 228320.0 8560.0 0.23 219480.0 8560.0 0.22 0.3154 0.9997 2060476 SPBio_003024 C[C@H]1[C@@H]2CCC(=C3[C@@H]([C@H]2OC1=O)C(=CC3=O)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J10 mock treatment 231680.0 11900.0 0.32 214200.0 3280.0 0.08 0.2838 0.8635 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J11 compound treatment 234280.0 14500.0 0.39 229280.0 18400.0 0.47 0.604 0.9957 1336284 SPBio_003025 COc1c2CC(Oc2nc3ccccc13)C(C)(O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J12 mock treatment 224120.0 4360.0 0.12 228600.0 17700.0 0.45 0.4002 0.8617 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J13 compound treatment 225560.0 5800.0 0.15 223040.0 12100.0 0.31 0.3274 0.9492 3176921 SPBio_003026 N[C@H]1CONC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J14 mock treatment 229440.0 9680.0 0.26 216200.0 5280.0 0.13 0.2776 0.9536 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J15 compound treatment 226040.0 6280.0 0.17 223560.0 12600.0 0.32 0.3458 0.9539 3069855 SPBio_003027 Clc1cnccn1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J16 mock treatment 224680.0 4920.0 0.13 221320.0 10400.0 0.26 0.2799 0.9478 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J17 compound treatment 205600.0 -14200.0 -0.38 216080.0 5160.0 0.13 -0.1741 -0.4356 1076620 SPBio_003028 CNCC(O)c1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J18 mock treatment 235400.0 15600.0 0.42 210400.0 -518.0 -0.01 0.2856 0.6844 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J19 compound treatment 210040.0 -9720.0 -0.26 217640.0 6720.0 0.17 -0.0623 -0.2008 760 SPBio_003029 N[C@@H]1CONC1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J20 mock treatment 202200.0 -17600.0 -0.47 219880.0 8960.0 0.23 -0.1698 -0.3263 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J21 compound treatment 204800.0 -15000.0 -0.4 206680.0 -4240.0 -0.11 -0.3582 -0.8671 1076027 SPBio_003030 CC1CC(CC(C)(C)C1)OC(=O)c2ccccc2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J22 mock treatment 194880.0 -24900.0 -0.66 208840.0 -2080.0 -0.05 -0.5063 -0.761 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J23 mock treatment 200080.0 -19700.0 -0.52 217920.0 7000.0 0.18 -0.2451 -0.4424 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 J24 mock treatment 229480.0 9720.0 0.26 183680.0 -27200.0 -0.69 -0.3064 -0.4143 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K01 mock treatment 219320.0 -435.0 -0.01 179840.0 -31100.0 -0.79 -0.567 -0.7174 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K02 mock treatment 207960.0 -11800.0 -0.31 207840.0 -3080.0 -0.08 -0.2777 -0.8569 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K03 compound treatment 199600.0 -20200.0 -0.54 211000.0 82.0 0.0 -0.3785 -0.7044 1677 SPBio_003031 CC(C)c1cccc(C(C)C)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K04 compound treatment 215280.0 -4480.0 -0.12 232960.0 22000.0 0.56 0.3119 0.5444 3188147 SPBio_003032 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)C(N3C2=O)C(=O)O)c4c(F)cccc4Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K05 compound treatment 109520.0 -110000.0 -2.94 131600.0 -79300.0 -2.02 -3.5044 -0.9831 3188019 SPBio_003033 CCN1CCCC1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K06 compound treatment 196360.0 -23400.0 -0.62 239640.0 28700.0 0.73 0.0753 0.0784 2920 SPBio_003034 CCN(CC)c1cc(C)nc2ncnn12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K07 compound treatment 206600.0 -13200.0 -0.35 208400.0 -2520.0 -0.06 -0.2933 -0.8226 962 SPBio_003035 CCC1(C(=O)NCNC1=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K08 compound treatment 191280.0 -28500.0 -0.76 194320.0 -16600.0 -0.42 -0.8353 -0.9616 3188148 SPBio_003036 CN1C2CCC1CC(C2)OC3c4ccccc4CCc5ccccc35 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K09 compound treatment 241680.0 21900.0 0.58 196640.0 -14300.0 -0.36 0.1566 0.2276 1910 SPBio_003037 Nc1nc(=O)[nH]cc1F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K10 compound treatment 138240.0 -81500.0 -2.17 90720.0 -120000.0 -3.06 -3.6979 -0.986 3069806 SPBio_003038 OCCOCCOC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K11 compound treatment 234280.0 14500.0 0.39 194440.0 -16500.0 -0.42 -0.0224 -0.0393 3069740 SPBio_003039 C[C@]1(N[C@H]2Cc3ccccc31)c4ccccc24 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K12 compound treatment 222920.0 3160.0 0.08 211080.0 162.0 0.0 0.0626 0.7407 1022844 SPBio_003040 Oc1ccc(O)c(c1)S(=O)(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K13 compound treatment 208920.0 -10800.0 -0.29 207800.0 -3120.0 -0.08 -0.2603 -0.869 3188020 SPBio_003041 C[N+](C)(CCCOc1ccccc1)c2ccccc2.OC(=O)c1cc2ccccc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K14 compound treatment 215160.0 -4600.0 -0.12 228280.0 17400.0 0.44 0.2255 0.4922 1779 SPBio_003042 COc1nc(C)nc(Cl)c1NC2=NCCN2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K15 compound treatment 222360.0 2600.0 0.07 217480.0 6560.0 0.17 0.1671 0.9245 3069741 SPBio_003043 CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CCC4=O)[C@@H]3CC=C2C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K16 compound treatment 222880.0 3120.0 0.08 216000.0 5080.0 0.13 0.1503 0.9775 1326779 SPBio_003044 CCNCC(O)c1cccc(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K17 compound treatment 218920.0 -835.0 -0.02 208680.0 -2240.0 -0.06 -0.056 -0.9162 1095 SPBio_003045 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K18 compound treatment 248720.0 29000.0 0.77 223600.0 12700.0 0.32 0.7741 0.925 220 SPBio_003046 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K19 compound treatment 210560.0 -9200.0 -0.25 215080.0 4160.0 0.11 -0.0985 -0.369 2685 SPBio_003047 OC(=O)c1c(I)cc(I)c(NC(=O)CCCCC(=O)Nc2c(I)cc(I)c(C(=O)O)c2I)c1I 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K20 compound treatment 215320.0 -4440.0 -0.12 206600.0 -4320.0 -0.11 -0.1613 -0.9993 3188149 SPBio_003048 CCO[C@@H]1O[C@H](C(COCc2ccccc2)OCc3ccccc3)[C@@H](OCc4ccccc4)C1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K21 compound treatment 169840.0 -49900.0 -1.33 154920.0 -56000.0 -1.42 -1.9479 -0.9994 1020463 SPBio_003049 Oc1cc2ccc(=O)oc2cc1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K22 compound treatment 207920.0 -11800.0 -0.32 195640.0 -15300.0 -0.39 -0.4978 -0.9947 3188150 SPBio_003050 CCC(=O)[C@@]1(C)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K23 mock treatment 190000.0 -29800.0 -0.79 199400.0 -11500.0 -0.29 -0.7681 -0.9082 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 K24 mock treatment 220160.0 405.0 0.01 185080.0 -25800.0 -0.66 -0.4569 -0.6954 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L01 mock treatment 223320.0 3560.0 0.1 166440.0 -44500.0 -1.13 -0.7325 -0.6454 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L02 mock treatment 233280.0 13500.0 0.36 218080.0 7160.0 0.18 0.3837 0.9499 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L03 compound treatment 204120.0 -15600.0 -0.42 231200.0 20300.0 0.52 0.0699 0.1054 1269 SPBio_003051 CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L04 mock treatment 221480.0 1720.0 0.05 219840.0 8920.0 0.23 0.1929 0.8335 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L05 compound treatment 210080.0 -9680.0 -0.26 235600.0 24700.0 0.63 0.2614 0.3852 3069858 SPBio_003052 Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(=O)(O)O[C@@H]4C3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L06 mock treatment 232000.0 12200.0 0.33 235800.0 24900.0 0.63 0.6782 0.9526 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L07 compound treatment 226520.0 6760.0 0.18 211600.0 682.0 0.02 0.1398 0.7715 907479 SPBio_003053 CCCN1CCC[C@@H]2Cc3n[nH]cc3C[C@H]21 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L08 mock treatment 287040.0 67300.0 1.79 213360.0 2440.0 0.06 1.3124 0.7311 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L09 compound treatment 233320.0 13600.0 0.36 207440.0 -3480.0 -0.09 0.1932 0.5189 3188280 SPBio_003054 COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L10 mock treatment 237720.0 18000.0 0.48 200000.0 -10900.0 -0.28 0.1424 0.2572 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L11 compound treatment 240240.0 20500.0 0.55 223880.0 13000.0 0.33 0.6192 0.9708 1221 SPBio_003055 CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L12 mock treatment 239520.0 19800.0 0.53 234280.0 23400.0 0.59 0.7927 0.9982 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L13 compound treatment 215960.0 -3800.0 -0.1 239200.0 28300.0 0.72 0.4369 0.6017 3188281 SPBio_003056 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2C[C@@H](O)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L14 mock treatment 238200.0 18400.0 0.49 231280.0 20400.0 0.52 0.7138 0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L15 compound treatment 217800.0 -1960.0 -0.05 234480.0 23600.0 0.6 0.3868 0.6431 1479 SPBio_003057 CC(C)NCC(O)c1ccc(O)c(O)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L16 mock treatment 250800.0 31000.0 0.83 207160.0 -3760.0 -0.1 0.5177 0.6214 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L17 compound treatment 224880.0 5120.0 0.14 206600.0 -4320.0 -0.11 0.019 0.1083 2121 SPBio_003058 Oc1ccc(cc1)c2oc3cc(O)cc(O)c3c(=O)c2O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L18 mock treatment 215000.0 -4760.0 -0.13 205960.0 -4960.0 -0.13 -0.1788 -1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L19 compound treatment 205160.0 -14600.0 -0.39 223200.0 12300.0 0.31 -0.0544 -0.1089 865102 SPBio_003059 O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L20 mock treatment 200120.0 -19600.0 -0.52 204680.0 -6240.0 -0.16 -0.4823 -0.8818 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L21 compound treatment 38800.0 -181000.0 -4.82 39680.0 -171000.0 -4.35 -6.4903 -0.9987 3188282 SPBio_003060 CC1C(C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)C(=O)c2ccccc2C1=O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L22 mock treatment 200880.0 -18900.0 -0.5 196640.0 -14300.0 -0.36 -0.6126 -0.9872 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L23 mock treatment 202960.0 -16800.0 -0.45 208320.0 -2600.0 -0.07 -0.3634 -0.8027 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 L24 mock treatment 232120.0 12400.0 0.33 168640.0 -42300.0 -1.07 -0.527 -0.4687 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M01 mock treatment 254120.0 34400.0 0.92 182400.0 -28500.0 -0.73 0.1352 0.1157 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M02 mock treatment 235680.0 15900.0 0.42 205840.0 -5080.0 -0.13 0.2089 0.4708 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M03 compound treatment 214320.0 -5440.0 -0.14 196800.0 -14100.0 -0.36 -0.3563 -0.9204 2030 SPBio_003061 OC(=O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M04 compound treatment 208320.0 -11400.0 -0.3 199280.0 -11600.0 -0.3 -0.4248 -0.9999 3480040 SPBio_003062 COC(=O)C1=C(C)NC(=C(C1c2cccc3nonc23)C(=O)OC(C)C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M05 compound treatment 225880.0 6120.0 0.16 191840.0 -19100.0 -0.49 -0.2275 -0.4446 907192 SPBio_003063 CC[N+](C)(C)Cc1ccccc1Br 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M06 compound treatment 207720.0 -12000.0 -0.32 203880.0 -7040.0 -0.18 -0.3534 -0.962 1077199 SPBio_003064 CCNC1(CCCCC1=O)c2cccs2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M07 compound treatment 216600.0 -3160.0 -0.08 189760.0 -21200.0 -0.54 -0.4399 -0.8079 3172714 SPBio_003065 C[n+]1ccccc1/C=N/O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M08 compound treatment 221080.0 1320.0 0.04 207800.0 -3120.0 -0.08 -0.0311 -0.3582 3069807 SPBio_003066 CNC(C)CCC=C(C)C.OC(C(O)C(O)C(=O)O)C(O)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M09 compound treatment 182600.0 -37200.0 -0.99 154920.0 -56000.0 -1.42 -1.7073 -0.9843 1395 SPBio_003067 CC(COc1ccccc1)N(CCCl)Cc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M10 compound treatment 221960.0 2200.0 0.06 204560.0 -6360.0 -0.16 -0.0727 -0.4229 3188151 SPBio_003068 CC1CS(=O)(=O)CCN1/N=C/c2ccc(o2)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M11 compound treatment 207920.0 -11800.0 -0.32 199880.0 -11000.0 -0.28 -0.4216 -0.9983 2844 SPBio_003069 CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M12 compound treatment 201880.0 -17900.0 -0.48 196680.0 -14200.0 -0.36 -0.593 -0.9908 1698 SPBio_003070 N#Cc1ccc(cc1)C(c2ccc(C#N)cc2)n3cncn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M13 compound treatment 226680.0 6920.0 0.18 209240.0 -1680.0 -0.04 0.1004 0.5297 1371 SPBio_003071 CN(C)c1nc(nc(n1)N(C)C)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M14 compound treatment 215600.0 -4160.0 -0.11 215200.0 4280.0 0.11 -0.0014 -0.0087 4425 SPBio_003072 CC(C)NCC1CCc2cc(CO)c(cc2N1)[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M15 compound treatment 213120.0 -6640.0 -0.18 200720.0 -10200.0 -0.26 -0.3085 -0.9826 349 SPBio_003073 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M16 compound treatment 211360.0 -8400.0 -0.22 205280.0 -5640.0 -0.14 -0.2596 -0.9768 3188152 SPBio_003074 CC(N)C(=O)Nc1c(C)cccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M17 compound treatment 209720.0 -10000.0 -0.27 214400.0 3480.0 0.09 -0.1266 -0.4492 1428570 SPBio_003075 CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M18 compound treatment 211800.0 -7960.0 -0.21 199200.0 -11700.0 -0.3 -0.3607 -0.9861 3188153 SPBio_003076 CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2C1C(=O)O.C(CNCc1ccccc1)NCc2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M19 compound treatment 209880.0 -9880.0 -0.26 205480.0 -5440.0 -0.14 -0.284 -0.9548 893 SPBio_003077 NCC(O)c1ccc(O)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M20 compound treatment 186880.0 -32900.0 -0.88 200160.0 -10800.0 -0.27 -0.8132 -0.8856 1795 SPBio_003078 Cc1nc2CCCCn2c(=O)c1CCN3CCC(CC3)c4noc5cc(F)ccc45 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M21 compound treatment 207560.0 -12200.0 -0.33 194760.0 -16200.0 -0.41 -0.5204 -0.9933 806 SPBio_003079 OC(=O)C1CCCNC1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M22 compound treatment 209840.0 -9920.0 -0.26 204760.0 -6160.0 -0.16 -0.2977 -0.9687 1001638 SPBio_003080 CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M23 mock treatment 204400.0 -15400.0 -0.41 198080.0 -12800.0 -0.33 -0.5203 -0.9937 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 M24 mock treatment 218560.0 -1200.0 -0.03 177520.0 -33400.0 -0.85 -0.623 -0.7331 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N01 mock treatment 237400.0 17600.0 0.47 191400.0 -19500.0 -0.5 -0.0183 -0.0267 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N02 mock treatment 228000.0 8240.0 0.22 216680.0 5760.0 0.15 0.259 0.9806 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N03 compound treatment 231880.0 12100.0 0.32 214920.0 4000.0 0.1 0.3005 0.8868 3487604 SPBio_003081 CCNC1CC(N)C(OC2OC(=CCC2N)CN)C(O)C1OC3OCC(C)(O)C(NC)C3O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N04 mock treatment 212080.0 -7680.0 -0.2 206800.0 -4120.0 -0.1 -0.2187 -0.9516 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N05 compound treatment 212680.0 -7080.0 -0.19 208000.0 -2920.0 -0.07 -0.1859 -0.9168 3173761 SPBio_003082 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N06 mock treatment 206800.0 -13000.0 -0.35 198320.0 -12600.0 -0.32 -0.4708 -0.9993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N07 compound treatment 215000.0 -4760.0 -0.13 188080.0 -22800.0 -0.58 -0.5003 -0.8417 1111897 SPBio_003083 COc1ccc2nccc(C(=O)O)c2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N08 mock treatment 217880.0 -1880.0 -0.05 201200.0 -9720.0 -0.25 -0.2101 -0.8333 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N09 compound treatment 237480.0 17700.0 0.47 197960.0 -13000.0 -0.33 0.1012 0.1756 3188283 SPBio_003084 CC1O[C@@H](OC/2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(=O)O)C[C@@H](O)C[C@H]4O[C@@H]4\C=C\C(=O)O[C@H](C)C\C=C\C=C\C=C\C=C2)C(O)C(N)[C@@H]1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N10 mock treatment 385480.0 166000.0 4.42 196800.0 -14100.0 -0.36 2.8706 0.6475 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N11 compound treatment 23480.0 -196000.0 -5.23 18320.0 -193000.0 -4.9 -7.1632 -0.9995 3188284 SPBio_003085 COC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5C)[C@]6(C)C(C(=O)OC)C(=CC=C46)C(=O)OC)c(C)c3C=C.COC(=O)CCc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)c(CCC(=O)O)c5C)c(C=C)c4C)C6=CC=C(C(C(=O)OC)[C@]63C)C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N12 mock treatment 208000.0 -11800.0 -0.31 202320.0 -8600.0 -0.22 -0.3762 -0.9845 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N13 compound treatment 222400.0 2640.0 0.07 205200.0 -5720.0 -0.15 -0.0529 -0.3277 1000348 SPBio_003086 C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(=O)O)S[C@@H]3CN[C@@H](C3)C(=O)N(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N14 mock treatment 234440.0 14700.0 0.39 227040.0 16100.0 0.41 0.5667 0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N15 compound treatment 224800.0 5040.0 0.13 200280.0 -10600.0 -0.27 -0.0962 -0.3183 3069861 SPBio_003087 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2C(C[C@@H]3CCC[C@@H]32)C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N16 mock treatment 234880.0 15100.0 0.4 183240.0 -27700.0 -0.7 -0.2125 -0.262 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N17 compound treatment 193760.0 -26000.0 -0.69 169120.0 -41800.0 -1.06 -1.2416 -0.9785 1517 SPBio_003088 CCC1(NC(=O)N(C)C1=O)c2ccccc2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N18 mock treatment 206800.0 -13000.0 -0.35 193480.0 -17400.0 -0.44 -0.5578 -0.9924 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N19 compound treatment 217360.0 -2400.0 -0.06 210840.0 -78.0 0.0 -0.0466 -0.7287 3188285 SPBio_003089 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4C5=NC6(CCN(CC(C)C)CC6)NC5=C(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)C(=O)c4c(O)c3C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N20 mock treatment 216240.0 -3520.0 -0.09 213560.0 2640.0 0.07 -0.0188 -0.1628 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N21 compound treatment 129880.0 -89900.0 -2.4 126920.0 -84000.0 -2.14 -3.2047 -0.9984 3069862 SPBio_003090 CCCCc1ccc2[nH]c(NC(=O)OC)nc2c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N22 mock treatment 200400.0 -19400.0 -0.52 206240.0 -4680.0 -0.12 -0.449 -0.8479 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N23 mock treatment 211520.0 -8240.0 -0.22 194000.0 -16900.0 -0.43 -0.4594 -0.9513 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 N24 mock treatment 208000.0 -11800.0 -0.31 196960.0 -14000.0 -0.35 -0.4726 -0.9981 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O01 mock treatment 228360.0 8600.0 0.23 188520.0 -22400.0 -0.57 -0.2405 -0.3917 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O02 mock treatment 342200.0 122000.0 3.26 208400.0 -2520.0 -0.06 2.2632 0.6931 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O03 compound treatment 242120.0 22400.0 0.6 207320.0 -3600.0 -0.09 0.357 0.5917 2660 SPBio_003091 CCN(C(=O)/C=C/C)c1ccccc1C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O04 compound treatment 218000.0 -1760.0 -0.05 184720.0 -26200.0 -0.67 -0.5041 -0.7549 2080909 SPBio_003092 CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O05 compound treatment 216680.0 -3080.0 -0.08 190640.0 -20300.0 -0.52 -0.4226 -0.8094 351 SPBio_003093 CC(C)NCC(O)COc1cccc2ccccc12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O06 compound treatment 225960.0 6200.0 0.17 193240.0 -17700.0 -0.45 -0.2009 -0.4194 3069809 SPBio_003094 CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O07 compound treatment 213160.0 -6600.0 -0.18 168520.0 -42400.0 -1.08 -0.8866 -0.8117 1001857 SPBio_003095 CC(C)NC[C@@H](O)COc1ccc(CC(=O)N)cc1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O08 compound treatment 216720.0 -3040.0 -0.08 175120.0 -35800.0 -0.91 -0.7009 -0.767 3188154 SPBio_003096 CC(=O)CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O09 compound treatment 243920.0 24200.0 0.64 113320.0 -97600.0 -2.48 -1.2992 -0.5067 3188022 SPBio_003097 CC(C)(C)CC(C)(C)c1ccc(OCOCCOCCO)c(Cc2cc(cc(Cc3cc(ccc3OCOCCOCCO)C(C)(C)CC(C)(C)C)c2OCOCCOCCO)C(C)(C)CC(C)(C)C)c1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O10 compound treatment 228000.0 8240.0 0.22 186640.0 -24300.0 -0.62 -0.2811 -0.4289 3177327 SPBio_003098 CC(=O)O[C@H]1[C@H](C[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C)[C@H](C[C@]4(C)[C@H]3CC[C@]12C)[N+]5(C)CCCCC5)[N+]6(C)CCCCC6 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O11 compound treatment 260360.0 40600.0 1.08 214160.0 3240.0 0.08 0.8238 0.7588 3069742 SPBio_003099 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O12 compound treatment 249240.0 29500.0 0.79 214200.0 3280.0 0.08 0.6149 0.7778 1511611 SPBio_003100 CCc1c(C)[nH]c2CCC(CN3CCOCC3)C(=O)c12 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O13 compound treatment 242760.0 23000.0 0.61 229200.0 18300.0 0.46 0.7624 0.9906 4369 SPBio_003101 CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O14 compound treatment 260400.0 40600.0 1.08 240240.0 29300.0 0.75 1.2935 0.9833 3188155 SPBio_003102 OC/C=C\1/[C@@H]2C[C@@H]3[C@@H](CC[C@]34C5N(C=C6C7N(C=C52)c8ccccc8[C@]97CC[C@@H]%10[C@H]9C[C@H]6\C(=C\CO)\N%10CC=C)c%11ccccc%114)N1CC=C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O15 compound treatment 255000.0 35200.0 0.94 186480.0 -24400.0 -0.62 0.2251 0.1998 3069771 SPBio_003103 C[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O16 compound treatment 261840.0 42100.0 1.12 213640.0 2720.0 0.07 0.8424 0.7493 2747 SPBio_003104 Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O17 compound treatment 234600.0 14800.0 0.4 201400.0 -9520.0 -0.24 0.1087 0.2344 1000212 SPBio_003105 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O18 compound treatment 221960.0 2200.0 0.06 130360.0 -80600.0 -2.05 -1.4068 -0.6865 3069810 SPBio_003106 COc1ccc(C[C@](C)(N)C(=O)O)cc1OC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O19 compound treatment 175920.0 -43800.0 -1.17 143640.0 -67300.0 -1.71 -2.0361 -0.9827 4481 SPBio_003107 CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O20 compound treatment 209560.0 -10200.0 -0.27 202440.0 -8480.0 -0.22 -0.3446 -0.9934 3069811 SPBio_003108 C[C@@H]1CN(CC[C@]1(C(=O)O)c2ccccc2)[C@H]3CC[C@](CC3)(C#N)c4ccc(F)cc4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O21 compound treatment 233760.0 14000.0 0.37 221960.0 11000.0 0.28 0.4626 0.9901 1167 SPBio_003109 NCCCCCC(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O22 compound treatment 15040.0 -205000.0 -5.46 12680.0 -198000.0 -5.04 -7.4237 -0.9992 3188156 SPBio_003110 CN(C)c1ccc2[n+](C)c(/C=C\c3cc(C)n(c3C)c4ccccc4)ccc2c1.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O23 mock treatment 221720.0 1960.0 0.05 190680.0 -20200.0 -0.51 -0.3268 -0.6319 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 O24 mock treatment 275080.0 55300.0 1.48 197400.0 -13500.0 -0.34 0.8 0.5282 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P01 mock treatment 230080.0 10300.0 0.28 201760.0 -9160.0 -0.23 0.03 0.0832 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P02 mock treatment 240720.0 21000.0 0.56 194400.0 -16500.0 -0.42 0.0983 0.1405 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P03 compound treatment 221960.0 2200.0 0.06 190080.0 -20800.0 -0.53 -0.3331 -0.6248 3856 SPBio_003111 CNC1(C)C2CCC(C2)C1(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P04 mock treatment 237680.0 17900.0 0.48 173840.0 -37100.0 -0.94 -0.3287 -0.311 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P05 compound treatment 264760.0 45000.0 1.2 195880.0 -15000.0 -0.38 0.5781 0.459 3199 SPBio_003112 CNNCc1ccc(cc1)C(=O)NC(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P06 mock treatment 220440.0 685.0 0.02 186560.0 -24400.0 -0.62 -0.425 -0.686 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P07 compound treatment 237000.0 17200.0 0.46 211880.0 962.0 0.02 0.3424 0.7437 3188286 SPBio_003113 NCCCC(N)CC(=O)NC1CNC(=O)C(NC(=O)/C(=C/NC(=O)N)/NC(=O)C(CO)NC(=O)C(CO)NC1=O)C2CC(O)N=C(N)N2 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P08 mock treatment 253280.0 33500.0 0.89 195240.0 -15700.0 -0.4 0.3502 0.3578 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P09 compound treatment 272400.0 52600.0 1.4 137960.0 -73000.0 -1.86 -0.3192 -0.1372 3069863 SPBio_003114 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)N)NC(=O)c4ccc5ccccc5n4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P10 mock treatment 247800.0 28000.0 0.75 191840.0 -19100.0 -0.49 0.1857 0.2084 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P11 compound treatment 256240.0 36500.0 0.97 208120.0 -2800.0 -0.07 0.6375 0.6536 1509 SPBio_003115 Cn1c(COC(=O)N)ncc1[N+](=O)[O-] 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P12 mock treatment 280600.0 60800.0 1.62 227680.0 16800.0 0.43 1.4485 0.8636 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P13 compound treatment 248960.0 29200.0 0.78 246080.0 35200.0 0.89 1.1828 0.9976 1829 SPBio_003116 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(=O)(=O)N 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P14 mock treatment 263360.0 43600.0 1.16 225520.0 14600.0 0.37 1.0846 0.8887 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P15 compound treatment 245440.0 25700.0 0.68 190680.0 -20200.0 -0.51 0.1204 0.1405 1078453 SPBio_003117 Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P16 mock treatment 278160.0 58400.0 1.56 200680.0 -10200.0 -0.26 0.917 0.5808 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P17 compound treatment 278840.0 59100.0 1.58 181880.0 -29000.0 -0.74 0.5919 0.3402 3188288 SPBio_003118 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C[N+]3(C)CCCC3)\c4csc(N)n4 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P18 mock treatment 262320.0 42600.0 1.13 184240.0 -26700.0 -0.68 0.3228 0.2442 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P19 compound treatment 252040.0 32300.0 0.86 158360.0 -52600.0 -1.34 -0.3363 -0.2116 3188289 SPBio_003119 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P20 mock treatment 254760.0 35000.0 0.93 193480.0 -17400.0 -0.44 0.3464 0.3353 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P21 compound treatment 248320.0 28600.0 0.76 229760.0 18800.0 0.48 0.8773 0.975 2884 SPBio_003120 CC1(C)S[C@@H]2[C@H](NC(=O)C3(N)CCCCC3)C(=O)N2[C@H]1C(=O)O 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P22 mock treatment 225360.0 5600.0 0.15 216560.0 5640.0 0.14 0.2071 0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P23 mock treatment 215400.0 -4360.0 -0.12 207040.0 -3880.0 -0.1 -0.1518 -0.9967 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.2167 P24 mock treatment 192760.0 -27000.0 -0.72 173640.0 -37300.0 -0.95 -1.1792 -0.9908 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A01 mock treatment 259040.0 -8160.0 -0.22 258800.0 -10800.0 -0.28 -0.3488 -0.9932 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A02 mock treatment 239800.0 -27400.0 -0.73 249680.0 -20000.0 -0.51 -0.8755 -0.9842 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A03 mock treatment 253000.0 -14200.0 -0.38 252680.0 -17000.0 -0.43 -0.5727 -0.9979 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A04 mock treatment 261600.0 -5600.0 -0.15 263800.0 -5840.0 -0.15 -0.2106 -1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A05 mock treatment 239760.0 -27400.0 -0.73 239560.0 -30100.0 -0.76 -1.0582 -0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A06 mock treatment 222760.0 -44400.0 -1.18 250000.0 -19600.0 -0.5 -1.191 -0.9262 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A07 mock treatment 219680.0 -47500.0 -1.27 232400.0 -37200.0 -0.95 -1.5655 -0.9897 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A08 mock treatment 257720.0 -9480.0 -0.25 262560.0 -7080.0 -0.18 -0.3061 -0.9862 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A09 mock treatment 241080.0 -26100.0 -0.7 235280.0 -34400.0 -0.87 -1.1103 -0.9937 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A10 mock treatment 258960.0 -8240.0 -0.22 247960.0 -21700.0 -0.55 -0.5452 -0.9187 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A11 mock treatment 273200.0 6000.0 0.16 269120.0 -521.0 -0.01 0.1037 0.6464 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A12 mock treatment 271880.0 4680.0 0.12 276040.0 6400.0 0.16 0.2033 0.9914 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A13 mock treatment 279880.0 12700.0 0.34 276720.0 7080.0 0.18 0.3663 0.9565 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A14 mock treatment 266720.0 -482.0 -0.01 269840.0 199.0 0.01 -0.0055 -0.3981 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A15 mock treatment 261240.0 -5960.0 -0.16 249720.0 -19900.0 -0.51 -0.4706 -0.8864 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A16 mock treatment 246280.0 -20900.0 -0.56 247080.0 -22600.0 -0.57 -0.8001 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A17 mock treatment 249480.0 -17700.0 -0.47 251880.0 -17800.0 -0.45 -0.6534 -0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A18 mock treatment 233800.0 -33400.0 -0.89 249200.0 -20400.0 -0.52 -0.9972 -0.9671 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A19 mock treatment 262520.0 -4680.0 -0.12 248600.0 -21000.0 -0.53 -0.4666 -0.8493 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A20 mock treatment 271360.0 4160.0 0.11 267480.0 -2160.0 -0.05 0.0395 0.3196 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A21 mock treatment 255640.0 -11600.0 -0.31 258040.0 -11600.0 -0.29 -0.4265 -0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A22 mock treatment 264000.0 -3200.0 -0.09 256000.0 -13600.0 -0.35 -0.3056 -0.8556 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A23 mock treatment 269520.0 2320.0 0.06 283480.0 13800.0 0.35 0.2925 0.8188 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base A24 mock treatment 258800.0 -8400.0 -0.22 267280.0 -2360.0 -0.06 -0.2008 -0.866 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B01 mock treatment 272400.0 5200.0 0.14 273920.0 4280.0 0.11 0.1749 0.9928 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B02 mock treatment 246240.0 -21000.0 -0.56 259320.0 -10300.0 -0.26 -0.5808 -0.9406 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B03 mock treatment 252760.0 -14400.0 -0.39 236680.0 -33000.0 -0.84 -0.8649 -0.9377 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B04 mock treatment 239000.0 -28200.0 -0.75 248040.0 -21600.0 -0.55 -0.9201 -0.9881 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B05 mock treatment 254560.0 -12600.0 -0.34 264920.0 -4720.0 -0.12 -0.3232 -0.9033 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B06 mock treatment 254680.0 -12500.0 -0.33 260080.0 -9560.0 -0.24 -0.408 -0.9878 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B07 mock treatment 262400.0 -4800.0 -0.13 256360.0 -13300.0 -0.34 -0.3293 -0.9119 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B08 mock treatment 242480.0 -24700.0 -0.66 251160.0 -18500.0 -0.47 -0.7984 -0.9862 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B09 mock treatment 248760.0 -18400.0 -0.49 251920.0 -17700.0 -0.45 -0.6663 -0.999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B10 mock treatment 238800.0 -28400.0 -0.76 257240.0 -12400.0 -0.32 -0.7584 -0.9246 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B11 mock treatment 273840.0 6640.0 0.18 278040.0 8400.0 0.21 0.2762 0.9956 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B12 mock treatment 282040.0 14800.0 0.4 267520.0 -2120.0 -0.05 0.2416 0.6051 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B13 mock treatment 287440.0 20200.0 0.54 278440.0 8800.0 0.22 0.5398 0.924 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B14 mock treatment 272080.0 4880.0 0.13 255040.0 -14600.0 -0.37 -0.1705 -0.4335 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B15 mock treatment 252560.0 -14600.0 -0.39 263640.0 -6000.0 -0.15 -0.3839 -0.916 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B16 mock treatment 242920.0 -24300.0 -0.65 258880.0 -10800.0 -0.27 -0.6513 -0.9266 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B17 mock treatment 231400.0 -35800.0 -0.95 236800.0 -32800.0 -0.84 -1.2654 -0.9978 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B18 mock treatment 240040.0 -27200.0 -0.72 238920.0 -30700.0 -0.78 -1.0644 -0.9993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B19 mock treatment 259040.0 -8160.0 -0.22 252120.0 -17500.0 -0.45 -0.4689 -0.9457 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B20 mock treatment 256440.0 -10800.0 -0.29 249280.0 -20400.0 -0.52 -0.569 -0.9613 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B21 mock treatment 259520.0 -7680.0 -0.2 271880.0 2240.0 0.06 -0.1046 -0.4919 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B22 mock treatment 249640.0 -17600.0 -0.47 270840.0 1200.0 0.03 -0.3095 -0.6597 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B23 mock treatment 258240.0 -8960.0 -0.24 253320.0 -16300.0 -0.41 -0.4624 -0.9656 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base B24 mock treatment 269760.0 2560.0 0.07 277360.0 7720.0 0.2 0.187 0.9 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C01 mock treatment 263240.0 -3960.0 -0.11 250280.0 -19400.0 -0.49 -0.4228 -0.8397 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C02 mock treatment 245400.0 -21800.0 -0.58 240840.0 -28800.0 -0.73 -0.9288 -0.9935 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C03 mock treatment 232760.0 -34400.0 -0.92 266960.0 -2680.0 -0.07 -0.6975 -0.7575 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C04 mock treatment 232240.0 -35000.0 -0.93 246880.0 -22800.0 -0.58 -1.0684 -0.9737 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C05 mock treatment 254360.0 -12800.0 -0.34 239080.0 -30600.0 -0.78 -0.7916 -0.9322 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C06 mock treatment 238560.0 -28600.0 -0.76 254160.0 -15500.0 -0.39 -0.8183 -0.9525 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C07 mock treatment 260400.0 -6800.0 -0.18 257760.0 -11900.0 -0.3 -0.3418 -0.9702 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C08 mock treatment 250600.0 -16600.0 -0.44 256080.0 -13600.0 -0.34 -0.5568 -0.9924 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C09 mock treatment 262480.0 -4720.0 -0.13 258080.0 -11600.0 -0.29 -0.2969 -0.9284 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C10 mock treatment 249080.0 -18100.0 -0.48 266320.0 -3320.0 -0.08 -0.4014 -0.8183 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C11 mock treatment 251120.0 -16100.0 -0.43 270760.0 1120.0 0.03 -0.2831 -0.6587 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C12 mock treatment 258960.0 -8240.0 -0.22 263040.0 -6600.0 -0.17 -0.2741 -0.9911 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C13 mock treatment 266920.0 -282.0 -0.01 286480.0 16800.0 0.43 0.2974 0.6946 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C14 mock treatment 261200.0 -6000.0 -0.16 243240.0 -26400.0 -0.67 -0.5878 -0.8518 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C15 mock treatment 236720.0 -30500.0 -0.81 267640.0 -2000.0 -0.05 -0.6107 -0.7499 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C16 mock treatment 234200.0 -33000.0 -0.88 258360.0 -11300.0 -0.29 -0.825 -0.8914 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C17 mock treatment 249480.0 -17700.0 -0.47 245480.0 -24200.0 -0.61 -0.7685 -0.9916 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C18 mock treatment 238960.0 -28200.0 -0.75 241160.0 -28500.0 -0.72 -1.0445 -0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C19 mock treatment 231160.0 -36000.0 -0.96 236280.0 -33400.0 -0.85 -1.2793 -0.9981 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C20 mock treatment 227320.0 -39900.0 -1.06 238680.0 -31000.0 -0.79 -1.3086 -0.9891 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C21 mock treatment 241080.0 -26100.0 -0.7 244160.0 -25500.0 -0.65 -0.9506 -0.9993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C22 mock treatment 247400.0 -19800.0 -0.53 230080.0 -39600.0 -1.01 -1.0846 -0.9547 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C23 mock treatment 231600.0 -35600.0 -0.95 243560.0 -26100.0 -0.66 -1.1401 -0.9846 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base C24 mock treatment 245880.0 -21300.0 -0.57 240240.0 -29400.0 -0.75 -0.9306 -0.9909 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D01 mock treatment 254920.0 -12300.0 -0.33 241560.0 -28100.0 -0.71 -0.7364 -0.9375 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D02 mock treatment 246800.0 -20400.0 -0.54 236320.0 -33300.0 -0.85 -0.9837 -0.9771 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D03 mock treatment 239160.0 -28000.0 -0.75 233840.0 -35800.0 -0.91 -1.1723 -0.9952 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D04 mock treatment 255920.0 -11300.0 -0.3 254600.0 -15000.0 -0.38 -0.4831 -0.9929 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D05 mock treatment 245920.0 -21300.0 -0.57 239680.0 -30000.0 -0.76 -0.9399 -0.9895 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D06 mock treatment 243760.0 -23400.0 -0.63 272720.0 3080.0 0.08 -0.3866 -0.6137 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D07 mock treatment 259720.0 -7480.0 -0.2 248480.0 -21200.0 -0.54 -0.5215 -0.9088 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D08 mock treatment 261880.0 -5320.0 -0.14 262320.0 -7320.0 -0.19 -0.232 -0.991 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D09 mock treatment 240360.0 -26800.0 -0.72 266760.0 -2880.0 -0.07 -0.5578 -0.7754 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D10 mock treatment 268440.0 1240.0 0.03 260640.0 -9000.0 -0.23 -0.1385 -0.5989 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D11 mock treatment 253560.0 -13600.0 -0.36 271880.0 2240.0 0.06 -0.2169 -0.5892 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D12 mock treatment 266280.0 -922.0 -0.02 267080.0 -2560.0 -0.07 -0.0634 -0.9113 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D13 mock treatment 287960.0 20800.0 0.55 276560.0 6920.0 0.18 0.5158 0.8881 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D14 mock treatment 250720.0 -16500.0 -0.44 257800.0 -11800.0 -0.3 -0.5236 -0.983 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D15 mock treatment 263080.0 -4120.0 -0.11 255480.0 -14200.0 -0.36 -0.3323 -0.8827 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D16 mock treatment 253920.0 -13300.0 -0.35 271600.0 1960.0 0.05 -0.2152 -0.6017 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D17 mock treatment 239200.0 -28000.0 -0.75 251080.0 -18600.0 -0.47 -0.8616 -0.9755 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D18 mock treatment 248760.0 -18400.0 -0.49 263200.0 -6440.0 -0.16 -0.4635 -0.8943 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D19 mock treatment 237080.0 -30100.0 -0.8 246400.0 -23200.0 -0.59 -0.9857 -0.9886 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D20 mock treatment 259320.0 -7880.0 -0.21 239840.0 -29800.0 -0.76 -0.6844 -0.8704 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D21 mock treatment 238280.0 -28900.0 -0.77 245080.0 -24600.0 -0.62 -0.9869 -0.9945 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D22 mock treatment 249560.0 -17600.0 -0.47 242800.0 -26800.0 -0.68 -0.8152 -0.9835 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D23 mock treatment 252720.0 -14500.0 -0.39 252240.0 -17400.0 -0.44 -0.5859 -0.9977 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base D24 mock treatment 245640.0 -21600.0 -0.57 243800.0 -25800.0 -0.66 -0.8711 -0.9978 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E01 mock treatment 252520.0 -14700.0 -0.39 236320.0 -33300.0 -0.85 -0.8759 -0.9385 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E02 mock treatment 251160.0 -16000.0 -0.43 248560.0 -21100.0 -0.54 -0.6815 -0.9937 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E03 mock treatment 273800.0 6600.0 0.18 260200.0 -9440.0 -0.24 -0.0453 -0.1523 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E04 mock treatment 248480.0 -18700.0 -0.5 265200.0 -4440.0 -0.11 -0.4328 -0.8457 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E05 mock treatment 277000.0 9800.0 0.26 262080.0 -7560.0 -0.19 0.0488 0.1504 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E06 mock treatment 258480.0 -8720.0 -0.23 250360.0 -19300.0 -0.49 -0.5111 -0.9419 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E07 mock treatment 275040.0 7840.0 0.21 270760.0 1120.0 0.03 0.1679 0.7961 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E08 mock treatment 262120.0 -5080.0 -0.14 269680.0 39.5 0.0 -0.0951 -0.7019 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E09 mock treatment 271480.0 4280.0 0.11 267680.0 -1960.0 -0.05 0.0454 0.3648 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E10 mock treatment 263560.0 -3640.0 -0.1 266240.0 -3400.0 -0.09 -0.1298 -0.9983 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E11 mock treatment 272400.0 5200.0 0.14 261200.0 -8440.0 -0.21 -0.0538 -0.2104 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E12 mock treatment 279760.0 12600.0 0.33 299560.0 29900.0 0.76 0.7747 0.932 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E13 mock treatment 251920.0 -15300.0 -0.41 270160.0 519.0 0.01 -0.2788 -0.6838 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E14 mock treatment 269720.0 2520.0 0.07 275720.0 6080.0 0.15 0.1568 0.9303 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E15 mock treatment 275400.0 8200.0 0.22 272600.0 2960.0 0.08 0.2078 0.8988 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E16 mock treatment 249800.0 -17400.0 -0.46 259520.0 -10100.0 -0.26 -0.51 -0.9613 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E17 mock treatment 245040.0 -22200.0 -0.59 267280.0 -2360.0 -0.06 -0.4603 -0.7749 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E18 mock treatment 245680.0 -21500.0 -0.57 255080.0 -14600.0 -0.37 -0.6675 -0.9775 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E19 mock treatment 248440.0 -18800.0 -0.5 258080.0 -11600.0 -0.29 -0.5616 -0.9679 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E20 mock treatment 242840.0 -24400.0 -0.65 256640.0 -13000.0 -0.33 -0.693 -0.9509 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E21 mock treatment 249240.0 -18000.0 -0.48 254480.0 -15200.0 -0.39 -0.6112 -0.9942 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E22 mock treatment 251640.0 -15600.0 -0.41 252720.0 -16900.0 -0.43 -0.5976 -0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E23 mock treatment 245360.0 -21800.0 -0.58 261600.0 -8040.0 -0.2 -0.5564 -0.9014 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base E24 mock treatment 239160.0 -28000.0 -0.75 242600.0 -27000.0 -0.69 -1.0149 -0.9991 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F01 mock treatment 250120.0 -17100.0 -0.46 266800.0 -2840.0 -0.07 -0.3731 -0.8091 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F02 mock treatment 238160.0 -29000.0 -0.77 260600.0 -9040.0 -0.23 -0.7101 -0.8791 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F03 mock treatment 246160.0 -21000.0 -0.56 259240.0 -10400.0 -0.26 -0.5837 -0.9411 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F04 mock treatment 275440.0 8240.0 0.22 260800.0 -8840.0 -0.22 -0.0036 -0.0116 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F05 mock treatment 291560.0 24400.0 0.65 261960.0 -7680.0 -0.2 0.3211 0.4735 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F06 mock treatment 245080.0 -22100.0 -0.59 257120.0 -12500.0 -0.32 -0.6422 -0.9581 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F07 mock treatment 260320.0 -6880.0 -0.18 255320.0 -14300.0 -0.36 -0.3872 -0.9497 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F08 mock treatment 279440.0 12200.0 0.33 272160.0 2520.0 0.06 0.276 0.8301 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F09 mock treatment 252920.0 -14300.0 -0.38 275080.0 5440.0 0.14 -0.1715 -0.4232 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F10 mock treatment 290880.0 23700.0 0.63 293680.0 24000.0 0.61 0.8786 0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F11 mock treatment 291720.0 24500.0 0.65 412280.0 143000.0 3.63 3.0268 0.8213 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F12 mock treatment 298680.0 31500.0 0.84 279480.0 9840.0 0.25 0.7704 0.8796 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F13 mock treatment 303800.0 36600.0 0.98 281440.0 11800.0 0.3 0.9021 0.8837 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F14 mock treatment 423920.0 157000.0 4.18 247480.0 -22200.0 -0.56 2.5562 0.6063 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F15 mock treatment 274000.0 6800.0 0.18 271080.0 1440.0 0.04 0.154 0.8331 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F16 mock treatment 252320.0 -14900.0 -0.4 270880.0 1240.0 0.03 -0.2583 -0.6489 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F17 mock treatment 267720.0 518.0 0.01 302040.0 32400.0 0.82 0.5923 0.7189 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F18 mock treatment 282000.0 14800.0 0.39 245760.0 -23900.0 -0.61 -0.1504 -0.2076 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F19 mock treatment 256560.0 -10600.0 -0.28 274720.0 5080.0 0.13 -0.1093 -0.3506 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F20 mock treatment 264080.0 -3120.0 -0.08 267680.0 -1960.0 -0.05 -0.0941 -0.9699 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F21 mock treatment 243960.0 -23200.0 -0.62 284320.0 14700.0 0.37 -0.1743 -0.2409 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F22 mock treatment 244200.0 -23000.0 -0.61 268560.0 -1080.0 -0.03 -0.4531 -0.738 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F23 mock treatment 256760.0 -10400.0 -0.28 262200.0 -7440.0 -0.19 -0.3306 -0.9823 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base F24 mock treatment 252520.0 -14700.0 -0.39 259600.0 -10000.0 -0.26 -0.4573 -0.9785 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G01 mock treatment 250240.0 -17000.0 -0.45 271640.0 2000.0 0.05 -0.2838 -0.6237 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G02 mock treatment 249160.0 -18000.0 -0.48 243080.0 -26600.0 -0.68 -0.8177 -0.9862 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G03 mock treatment 261840.0 -5360.0 -0.14 242760.0 -26900.0 -0.68 -0.5844 -0.8369 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G04 mock treatment 256840.0 -10400.0 -0.28 251600.0 -18000.0 -0.46 -0.5197 -0.9705 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G05 mock treatment 290080.0 22900.0 0.61 286920.0 17300.0 0.44 0.742 0.987 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G06 mock treatment 267600.0 398.0 0.01 261920.0 -7720.0 -0.2 -0.1313 -0.6679 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G07 mock treatment 268480.0 1280.0 0.03 279240.0 9600.0 0.24 0.1967 0.7981 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G08 mock treatment 261400.0 -5800.0 -0.15 279560.0 9920.0 0.25 0.069 0.2331 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G09 mock treatment 264760.0 -2440.0 -0.07 266560.0 -3080.0 -0.08 -0.1014 -0.9958 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G10 mock treatment 292200.0 25000.0 0.67 297120.0 27500.0 0.7 0.9654 0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G11 mock treatment 280440.0 13200.0 0.35 274000.0 4360.0 0.11 0.328 0.8865 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G12 mock treatment 279880.0 12700.0 0.34 277760.0 8120.0 0.21 0.385 0.972 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G13 mock treatment 304240.0 37000.0 0.99 288680.0 19000.0 0.48 1.0406 0.9462 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G14 mock treatment 290840.0 23600.0 0.63 282080.0 12400.0 0.32 0.6693 0.9491 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G15 mock treatment 276120.0 8920.0 0.24 264400.0 -5240.0 -0.13 0.0739 0.2712 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G16 mock treatment 270760.0 3560.0 0.09 294160.0 24500.0 0.62 0.5079 0.8054 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G17 mock treatment 264600.0 -2600.0 -0.07 262800.0 -6840.0 -0.17 -0.172 -0.9188 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G18 mock treatment 239720.0 -27500.0 -0.73 258320.0 -11300.0 -0.29 -0.7217 -0.9167 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G19 mock treatment 238040.0 -29200.0 -0.78 258560.0 -11100.0 -0.28 -0.749 -0.9057 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G20 mock treatment 252160.0 -15000.0 -0.4 266440.0 -3200.0 -0.08 -0.3411 -0.8336 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G21 mock treatment 261080.0 -6120.0 -0.16 249120.0 -20500.0 -0.52 -0.4844 -0.886 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G22 mock treatment 249440.0 -17800.0 -0.47 265160.0 -4480.0 -0.11 -0.4154 -0.8529 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G23 mock treatment 247560.0 -19600.0 -0.52 244000.0 -25600.0 -0.65 -0.8313 -0.9941 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base G24 mock treatment 259040.0 -8160.0 -0.22 263840.0 -5800.0 -0.15 -0.2582 -0.982 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H01 mock treatment 273520.0 6320.0 0.17 272560.0 2920.0 0.07 0.1716 0.9322 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H02 mock treatment 253000.0 -14200.0 -0.38 253400.0 -16200.0 -0.41 -0.5597 -0.9991 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H03 mock treatment 258000.0 -9200.0 -0.25 271840.0 2200.0 0.06 -0.1339 -0.5323 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H04 mock treatment 261320.0 -5880.0 -0.16 254960.0 -14700.0 -0.37 -0.3748 -0.9258 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H05 mock treatment 285720.0 18500.0 0.49 274280.0 4640.0 0.12 0.4325 0.8521 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H06 mock treatment 277400.0 10200.0 0.27 252440.0 -17200.0 -0.44 -0.117 -0.2272 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H07 mock treatment 249080.0 -18100.0 -0.48 309000.0 39400.0 1.0 0.366 0.3293 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H08 mock treatment 261240.0 -5960.0 -0.16 271720.0 2080.0 0.05 -0.075 -0.4478 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H09 mock treatment 257320.0 -9880.0 -0.26 289720.0 20100.0 0.51 0.1747 0.3041 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H10 mock treatment 284120.0 16900.0 0.45 279000.0 9360.0 0.24 0.4872 0.9554 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H11 mock treatment 302000.0 34800.0 0.93 277080.0 7440.0 0.19 0.7898 0.8341 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H12 mock treatment 290680.0 23500.0 0.63 289880.0 20200.0 0.51 0.8065 0.9953 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H13 mock treatment 299640.0 32400.0 0.86 280360.0 10700.0 0.27 0.8043 0.8869 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H14 mock treatment 304320.0 37100.0 0.99 302480.0 32800.0 0.83 1.2902 0.9964 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H15 mock treatment 323640.0 56400.0 1.5 286080.0 16400.0 0.42 1.3596 0.8706 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H16 mock treatment 316400.0 49200.0 1.31 265160.0 -4480.0 -0.11 0.847 0.6433 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H17 mock treatment 299200.0 32000.0 0.85 311920.0 42300.0 1.08 1.3634 0.9934 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H18 mock treatment 263760.0 -3440.0 -0.09 271440.0 1800.0 0.05 -0.0325 -0.3173 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H19 mock treatment 259360.0 -7840.0 -0.21 280320.0 10700.0 0.27 0.0442 0.1289 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H20 mock treatment 265400.0 -1800.0 -0.05 267800.0 -1840.0 -0.05 -0.0671 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H21 mock treatment 242560.0 -24600.0 -0.66 266480.0 -3160.0 -0.08 -0.5214 -0.7877 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H22 mock treatment 249800.0 -17400.0 -0.46 258080.0 -11600.0 -0.29 -0.5359 -0.9757 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H23 mock treatment 274400.0 7200.0 0.19 295920.0 26300.0 0.67 0.6082 0.8748 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base H24 mock treatment 268560.0 1360.0 0.04 266160.0 -3480.0 -0.09 -0.037 -0.3867 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I01 mock treatment 256520.0 -10700.0 -0.28 253760.0 -15900.0 -0.4 -0.4869 -0.9854 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I02 mock treatment 239160.0 -28000.0 -0.75 238400.0 -31200.0 -0.79 -1.0904 -0.9995 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I03 mock treatment 235120.0 -32100.0 -0.86 247480.0 -22200.0 -0.56 -1.0033 -0.9795 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I04 mock treatment 256320.0 -10900.0 -0.29 260880.0 -8760.0 -0.22 -0.3627 -0.9915 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I05 mock treatment 252360.0 -14800.0 -0.4 253240.0 -16400.0 -0.42 -0.5747 -0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I06 mock treatment 248160.0 -19000.0 -0.51 248840.0 -20800.0 -0.53 -0.733 -0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I07 mock treatment 250280.0 -16900.0 -0.45 276640.0 7000.0 0.18 -0.1932 -0.3983 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I08 mock treatment 271560.0 4360.0 0.12 266680.0 -2960.0 -0.08 0.0289 0.209 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I09 mock treatment 260600.0 -6600.0 -0.18 296160.0 26500.0 0.67 0.3523 0.5056 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I10 mock treatment 275440.0 8240.0 0.22 269520.0 -121.0 0.0 0.1531 0.6972 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I11 mock treatment 273320.0 6120.0 0.16 280000.0 10400.0 0.26 0.3016 0.9735 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I12 mock treatment 289960.0 22800.0 0.61 265320.0 -4320.0 -0.11 0.3514 0.5698 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I13 mock treatment 296320.0 29100.0 0.78 274760.0 5120.0 0.13 0.641 0.8143 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I14 mock treatment 297000.0 29800.0 0.79 282160.0 12500.0 0.32 0.7869 0.9194 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I15 mock treatment 262560.0 -4640.0 -0.12 253680.0 -16000.0 -0.41 -0.3745 -0.8826 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I16 mock treatment 276240.0 9040.0 0.24 260360.0 -9280.0 -0.24 0.0035 0.0105 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I17 mock treatment 278280.0 11100.0 0.3 272800.0 3160.0 0.08 0.2657 0.8679 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I18 mock treatment 289200.0 22000.0 0.59 270000.0 359.0 0.01 0.4212 0.718 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I19 mock treatment 269040.0 1840.0 0.05 260200.0 -9440.0 -0.24 -0.1351 -0.5514 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I20 mock treatment 247880.0 -19300.0 -0.52 242680.0 -27000.0 -0.69 -0.849 -0.9901 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I21 mock treatment 251560.0 -15600.0 -0.42 276040.0 6400.0 0.16 -0.1798 -0.4017 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I22 mock treatment 234480.0 -32700.0 -0.87 261800.0 -7840.0 -0.2 -0.7579 -0.8469 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I23 mock treatment 243720.0 -23500.0 -0.63 243080.0 -26600.0 -0.68 -0.9202 -0.9993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base I24 mock treatment 276840.0 9640.0 0.26 266640.0 -3000.0 -0.08 0.1278 0.4766 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J01 mock treatment 278480.0 11300.0 0.3 316160.0 46500.0 1.18 1.049 0.8595 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J02 mock treatment 262480.0 -4720.0 -0.13 256080.0 -13600.0 -0.34 -0.3328 -0.9067 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J03 mock treatment 247320.0 -19900.0 -0.53 259640.0 -10000.0 -0.25 -0.5546 -0.9434 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J04 mock treatment 281200.0 14000.0 0.37 257120.0 -12500.0 -0.32 0.0388 0.0791 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J05 mock treatment 259360.0 -7840.0 -0.21 258080.0 -11600.0 -0.29 -0.3557 -0.9861 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J06 mock treatment 277960.0 10800.0 0.29 272280.0 2640.0 0.07 0.2503 0.8496 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J07 mock treatment 263400.0 -3800.0 -0.1 280720.0 11100.0 0.28 0.1275 0.4259 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J08 mock treatment 272280.0 5080.0 0.14 276040.0 6400.0 0.16 0.2108 0.9958 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J09 mock treatment 271040.0 3840.0 0.1 268680.0 -961.0 -0.02 0.0551 0.5236 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J10 mock treatment 244560.0 -22600.0 -0.6 453040.0 183000.0 4.66 2.8705 0.6105 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J11 mock treatment 291080.0 23900.0 0.64 283960.0 14300.0 0.36 0.7076 0.9649 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J12 mock treatment 285040.0 17800.0 0.48 295880.0 26200.0 0.67 0.8081 0.9862 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J13 mock treatment 284800.0 17600.0 0.47 312680.0 43000.0 1.09 1.1056 0.9285 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J14 mock treatment 305200.0 38000.0 1.01 399920.0 130000.0 3.31 3.0587 0.883 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J15 mock treatment 267960.0 758.0 0.02 294480.0 24800.0 0.63 0.4609 0.7294 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J16 mock treatment 341840.0 74600.0 1.99 274680.0 5040.0 0.13 1.4978 0.7511 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J17 mock treatment 285640.0 18400.0 0.49 284560.0 14900.0 0.38 0.6159 0.9918 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J18 mock treatment 273560.0 6360.0 0.17 271600.0 1960.0 0.05 0.1551 0.8778 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J19 mock treatment 250920.0 -16300.0 -0.43 274320.0 4680.0 0.12 -0.2228 -0.495 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J20 mock treatment 249160.0 -18000.0 -0.48 311960.0 42300.0 1.08 0.4207 0.3569 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J21 mock treatment 268120.0 918.0 0.02 265040.0 -4600.0 -0.12 -0.0654 -0.5473 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J22 mock treatment 249000.0 -18200.0 -0.49 373120.0 103000.0 2.63 1.5173 0.5671 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J23 mock treatment 258680.0 -8520.0 -0.23 266840.0 -2800.0 -0.07 -0.211 -0.8862 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base J24 mock treatment 262720.0 -4480.0 -0.12 272240.0 2600.0 0.07 -0.0378 -0.2765 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K01 mock treatment 285600.0 18400.0 0.49 300080.0 30400.0 0.77 0.8941 0.9758 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K02 mock treatment 248400.0 -18800.0 -0.5 253680.0 -16000.0 -0.41 -0.6414 -0.9945 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K03 mock treatment 285240.0 18000.0 0.48 265600.0 -4040.0 -0.1 0.2674 0.5438 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K04 mock treatment 272960.0 5760.0 0.15 358400.0 88800.0 2.26 1.7044 0.7535 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K05 mock treatment 302280.0 35100.0 0.94 296240.0 26600.0 0.68 1.1396 0.9873 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K06 mock treatment 305400.0 38200.0 1.02 354320.0 84700.0 2.15 2.2426 0.9416 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K07 mock treatment 260160.0 -7040.0 -0.19 286520.0 16900.0 0.43 0.1707 0.3644 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K08 mock treatment 256200.0 -11000.0 -0.29 373920.0 104000.0 2.65 1.6674 0.6251 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K09 mock treatment 304560.0 37400.0 1.0 337480.0 67800.0 1.72 1.924 0.9659 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K10 mock treatment 365000.0 97800.0 2.61 348840.0 79200.0 2.01 3.2678 0.9918 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K11 mock treatment 304280.0 37100.0 0.99 331320.0 61700.0 1.57 1.808 0.9752 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K12 mock treatment 311000.0 43800.0 1.17 337360.0 67700.0 1.72 2.0433 0.9821 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K13 mock treatment 334440.0 67200.0 1.79 299080.0 29400.0 0.75 1.797 0.925 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K14 mock treatment 304600.0 37400.0 1.0 321040.0 51400.0 1.31 1.6292 0.9911 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K15 mock treatment 328240.0 61000.0 1.63 281840.0 12200.0 0.31 1.3701 0.827 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K16 mock treatment 271440.0 4240.0 0.11 331640.0 62000.0 1.58 1.1946 0.7559 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K17 mock treatment 273120.0 5920.0 0.16 283800.0 14200.0 0.36 0.3662 0.9315 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K18 mock treatment 284480.0 17300.0 0.46 301400.0 31800.0 0.81 0.8968 0.9646 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K19 mock treatment 302840.0 35600.0 0.95 270600.0 959.0 0.02 0.6891 0.725 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K20 mock treatment 286160.0 19000.0 0.51 276240.0 6600.0 0.17 0.4761 0.8939 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K21 mock treatment 311840.0 44600.0 1.19 276600.0 6960.0 0.18 0.9667 0.8034 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K22 mock treatment 260160.0 -7040.0 -0.19 294360.0 24700.0 0.63 0.3117 0.4751 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K23 mock treatment 287680.0 20500.0 0.55 269320.0 -321.0 -0.01 0.3803 0.6965 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base K24 mock treatment 255680.0 -11500.0 -0.31 290000.0 20400.0 0.52 0.1488 0.2472 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L01 mock treatment 276920.0 9720.0 0.26 286160.0 16500.0 0.42 0.4802 0.9731 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L02 mock treatment 280120.0 12900.0 0.34 274760.0 5120.0 0.13 0.3356 0.9114 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L03 mock treatment 252840.0 -14400.0 -0.38 283920.0 14300.0 0.36 -0.014 -0.0266 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L04 mock treatment 265760.0 -1440.0 -0.04 267720.0 -1920.0 -0.05 -0.0617 -0.993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L05 mock treatment 284600.0 17400.0 0.46 338400.0 68800.0 1.75 1.5643 0.8648 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L06 mock treatment 292840.0 25600.0 0.68 261080.0 -8560.0 -0.22 0.3295 0.4592 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L07 mock treatment 281200.0 14000.0 0.37 292200.0 22600.0 0.57 0.6695 0.9783 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L08 mock treatment 350680.0 83500.0 2.23 312000.0 42400.0 1.08 2.3354 0.9445 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L09 mock treatment 291000.0 23800.0 0.63 321440.0 51800.0 1.32 1.38 0.9439 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L10 mock treatment 313400.0 46200.0 1.23 342120.0 72500.0 1.84 2.1741 0.9808 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L11 mock treatment 296520.0 29300.0 0.78 324400.0 54800.0 1.39 1.5373 0.9627 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L12 mock treatment 410800.0 144000.0 3.83 296000.0 26400.0 0.67 3.1812 0.8184 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L13 mock treatment 323160.0 56000.0 1.49 290920.0 21300.0 0.54 1.4376 0.9058 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L14 mock treatment 291960.0 24800.0 0.66 260200.0 -9440.0 -0.24 0.297 0.4229 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L15 mock treatment 344600.0 77400.0 2.06 322120.0 52500.0 1.33 2.4028 0.9777 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L16 mock treatment 286680.0 19500.0 0.52 294280.0 24600.0 0.63 0.8102 0.9957 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L17 mock treatment 357880.0 90700.0 2.42 381320.0 112000.0 2.84 3.7175 0.9968 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L18 mock treatment 346920.0 79700.0 2.13 277480.0 7840.0 0.2 1.6439 0.77 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L19 mock treatment 273480.0 6280.0 0.17 295400.0 25800.0 0.65 0.5815 0.8602 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L20 mock treatment 270040.0 2840.0 0.08 309840.0 40200.0 1.02 0.7763 0.7574 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L21 mock treatment 268360.0 1160.0 0.03 351280.0 81600.0 2.08 1.4897 0.7175 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L22 mock treatment 254120.0 -13100.0 -0.35 275200.0 5560.0 0.14 -0.1467 -0.3897 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L23 mock treatment 268040.0 838.0 0.02 262520.0 -7120.0 -0.18 -0.1122 -0.6152 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base L24 mock treatment 272880.0 5680.0 0.15 280760.0 11100.0 0.28 0.307 0.9572 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M01 mock treatment 305040.0 37800.0 1.01 269880.0 239.0 0.01 0.7177 0.7114 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M02 mock treatment 254760.0 -12400.0 -0.33 246920.0 -22700.0 -0.58 -0.6431 -0.9653 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M03 mock treatment 246640.0 -20600.0 -0.55 248480.0 -21200.0 -0.54 -0.7681 -1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M04 mock treatment 259800.0 -7400.0 -0.2 242600.0 -27000.0 -0.69 -0.6257 -0.8748 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M05 mock treatment 261520.0 -5680.0 -0.15 257360.0 -12300.0 -0.31 -0.3279 -0.9448 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M06 mock treatment 269120.0 1920.0 0.05 264520.0 -5120.0 -0.13 -0.0559 -0.3996 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M07 mock treatment 275720.0 8520.0 0.23 278920.0 9280.0 0.24 0.3274 0.9998 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M08 mock treatment 283480.0 16300.0 0.43 264760.0 -4880.0 -0.12 0.2191 0.4855 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M09 mock treatment 289920.0 22700.0 0.61 279720.0 10100.0 0.26 0.6095 0.9267 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M10 mock treatment 295560.0 28400.0 0.76 292600.0 23000.0 0.58 0.9474 0.9918 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M11 mock treatment 280160.0 13000.0 0.35 294000.0 24400.0 0.62 0.6823 0.962 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M12 mock treatment 277400.0 10200.0 0.27 298400.0 28800.0 0.73 0.7093 0.9092 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M13 mock treatment 290120.0 22900.0 0.61 272680.0 3040.0 0.08 0.4867 0.7902 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M14 mock treatment 272920.0 5720.0 0.15 292200.0 22600.0 0.57 0.5134 0.865 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M15 mock treatment 262080.0 -5120.0 -0.14 277680.0 8040.0 0.2 0.048 0.1952 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M16 mock treatment 282760.0 15600.0 0.41 275080.0 5440.0 0.14 0.3911 0.8945 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M17 mock treatment 269800.0 2600.0 0.07 274720.0 5080.0 0.13 0.1403 0.9574 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M18 mock treatment 211760.0 -55400.0 -1.48 274680.0 5040.0 0.13 -0.9547 -0.6434 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M19 mock treatment 280320.0 13100.0 0.35 266000.0 -3640.0 -0.09 0.1819 0.5027 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M20 mock treatment 266920.0 -282.0 -0.01 266840.0 -2800.0 -0.07 -0.0557 -0.7774 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M21 mock treatment 261000.0 -6200.0 -0.17 263320.0 -6320.0 -0.16 -0.2306 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M22 mock treatment 239920.0 -27300.0 -0.73 247440.0 -22200.0 -0.56 -0.9135 -0.9921 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M23 mock treatment 250400.0 -16800.0 -0.45 259880.0 -9760.0 -0.25 -0.4923 -0.9612 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base M24 mock treatment 270040.0 2840.0 0.08 270240.0 599.0 0.02 0.0643 0.8328 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N01 mock treatment 283600.0 16400.0 0.44 277520.0 7880.0 0.2 0.4508 0.9374 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N02 mock treatment 250800.0 -16400.0 -0.44 260520.0 -9120.0 -0.23 -0.4732 -0.956 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N03 mock treatment 243160.0 -24000.0 -0.64 250520.0 -19100.0 -0.49 -0.797 -0.9907 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N04 mock treatment 248720.0 -18500.0 -0.49 246960.0 -22700.0 -0.58 -0.7562 -0.9969 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N05 mock treatment 270560.0 3360.0 0.09 267120.0 -2520.0 -0.06 0.018 0.1634 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N06 mock treatment 276400.0 9200.0 0.25 269520.0 -121.0 0.0 0.1712 0.6982 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N07 mock treatment 261360.0 -5840.0 -0.16 259000.0 -10600.0 -0.27 -0.3014 -0.9656 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N08 mock treatment 267240.0 38.1 0.0 259720.0 -9920.0 -0.25 -0.1776 -0.7043 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N09 mock treatment 266320.0 -882.0 -0.02 269320.0 -321.0 -0.01 -0.0224 -0.8997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N10 mock treatment 273600.0 6400.0 0.17 278600.0 8960.0 0.23 0.2817 0.9898 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N11 mock treatment 277840.0 10600.0 0.28 275320.0 5680.0 0.14 0.3027 0.951 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N12 mock treatment 296720.0 29500.0 0.79 294720.0 25100.0 0.64 1.0074 0.9946 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N13 mock treatment 288480.0 21300.0 0.57 284720.0 15100.0 0.38 0.6723 0.9818 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N14 mock treatment 281960.0 14800.0 0.39 263000.0 -6640.0 -0.17 0.1588 0.371 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N15 mock treatment 294800.0 27600.0 0.74 269360.0 -281.0 -0.01 0.5153 0.7002 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N16 mock treatment 262920.0 -4280.0 -0.11 268160.0 -1480.0 -0.04 -0.1073 -0.893 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N17 mock treatment 273560.0 6360.0 0.17 281920.0 12300.0 0.31 0.3406 0.9588 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N18 mock treatment 274160.0 6960.0 0.19 264280.0 -5360.0 -0.14 0.0348 0.1512 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N19 mock treatment 266600.0 -602.0 -0.02 268680.0 -961.0 -0.02 -0.0286 -0.9792 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N20 mock treatment 273800.0 6600.0 0.18 254280.0 -15400.0 -0.39 -0.1518 -0.3543 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N21 mock treatment 253880.0 -13300.0 -0.36 262480.0 -7160.0 -0.18 -0.3799 -0.9518 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N22 mock treatment 242120.0 -25100.0 -0.67 254400.0 -15200.0 -0.39 -0.7469 -0.9663 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N23 mock treatment 247240.0 -20000.0 -0.53 253160.0 -16500.0 -0.42 -0.6727 -0.993 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base N24 mock treatment 266960.0 -242.0 -0.01 261760.0 -7880.0 -0.2 -0.1462 -0.7295 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O01 mock treatment 251120.0 -16100.0 -0.43 252240.0 -17400.0 -0.44 -0.616 -0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O02 mock treatment 262200.0 -5000.0 -0.13 256240.0 -13400.0 -0.34 -0.3352 -0.9162 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O03 mock treatment 263840.0 -3360.0 -0.09 234360.0 -35300.0 -0.9 -0.6977 -0.7739 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O04 mock treatment 261520.0 -5680.0 -0.15 286000.0 16400.0 0.42 0.187 0.4224 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O05 mock treatment 282120.0 14900.0 0.4 266000.0 -3640.0 -0.09 0.2158 0.5284 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O06 mock treatment 293400.0 26200.0 0.7 246600.0 -23000.0 -0.59 0.0797 0.0874 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O07 mock treatment 266800.0 -402.0 -0.01 289280.0 19600.0 0.5 0.3455 0.6918 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O08 mock treatment 274440.0 7240.0 0.19 279320.0 9680.0 0.25 0.3105 0.9928 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O09 mock treatment 291760.0 24600.0 0.65 266440.0 -3200.0 -0.08 0.4055 0.6145 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O10 mock treatment 285520.0 18300.0 0.49 279520.0 9880.0 0.25 0.523 0.9522 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O11 mock treatment 408920.0 142000.0 3.78 284240.0 14600.0 0.37 2.9343 0.7729 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O12 mock treatment 333600.0 66400.0 1.77 303120.0 33500.0 0.85 1.8538 0.9437 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O13 mock treatment 341160.0 74000.0 1.97 286920.0 17300.0 0.44 1.705 0.844 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O14 mock treatment 283920.0 16700.0 0.45 318960.0 49300.0 1.25 1.2019 0.9031 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O15 mock treatment 300520.0 33300.0 0.89 512440.0 243000.0 6.17 4.9935 0.8006 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O16 mock treatment 311680.0 44500.0 1.19 318640.0 49000.0 1.25 1.7195 0.9997 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O17 mock treatment 323680.0 56500.0 1.51 336440.0 66800.0 1.7 2.2658 0.9982 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O18 mock treatment 328560.0 61400.0 1.64 320840.0 51200.0 1.3 2.0773 0.9936 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O19 mock treatment 352800.0 85600.0 2.28 276360.0 6720.0 0.17 1.7346 0.7579 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O20 mock treatment 285320.0 18100.0 0.48 283000.0 13400.0 0.34 0.5818 0.9852 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O21 mock treatment 289240.0 22000.0 0.59 305360.0 35700.0 0.91 1.0577 0.9778 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O22 mock treatment 296520.0 29300.0 0.78 300880.0 31200.0 0.79 1.1144 1.0 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O23 mock treatment 306000.0 38800.0 1.03 302000.0 32400.0 0.82 1.3133 0.9936 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base O24 mock treatment 284200.0 17000.0 0.45 328840.0 59200.0 1.51 1.3848 0.8809 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P01 mock treatment 231760.0 -35400.0 -0.94 243120.0 -26500.0 -0.67 -1.145 -0.9863 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P02 mock treatment 267400.0 198.0 0.01 269400.0 -241.0 -0.01 -6.0E-4 -0.0729 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P03 mock treatment 253000.0 -14200.0 -0.38 264400.0 -5240.0 -0.13 -0.362 -0.9017 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P04 mock treatment 303120.0 35900.0 0.96 276800.0 7160.0 0.18 0.8059 0.8267 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P05 mock treatment 275960.0 8760.0 0.23 284400.0 14800.0 0.38 0.4305 0.9739 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P06 mock treatment 277440.0 10200.0 0.27 261720.0 -7920.0 -0.2 0.0506 0.1492 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P07 mock treatment 285040.0 17800.0 0.48 292560.0 22900.0 0.58 0.7484 0.9949 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P08 mock treatment 296680.0 29500.0 0.79 302760.0 33100.0 0.84 1.1512 0.9994 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P09 mock treatment 325320.0 58100.0 1.55 296320.0 26700.0 0.68 1.5754 0.9313 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P10 mock treatment 300040.0 32800.0 0.88 346360.0 76700.0 1.95 1.9985 0.9347 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P11 mock treatment 311280.0 44100.0 1.18 327400.0 57800.0 1.47 1.8695 0.9939 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P12 mock treatment 308480.0 41300.0 1.1 288200.0 18600.0 0.47 1.1119 0.9285 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P13 mock treatment 324120.0 56900.0 1.52 308480.0 38800.0 0.99 1.7714 0.9783 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P14 mock treatment 303720.0 36500.0 0.97 306880.0 37200.0 0.95 1.358 0.9999 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P15 mock treatment 341320.0 74100.0 1.98 293480.0 23800.0 0.61 1.826 0.8834 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P16 mock treatment 348680.0 81500.0 2.17 316600.0 47000.0 1.19 2.3804 0.9603 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P17 mock treatment 352200.0 85000.0 2.27 299600.0 30000.0 0.76 2.1411 0.8955 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P18 mock treatment 304080.0 36900.0 0.98 357240.0 87600.0 2.23 2.2702 0.9324 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P19 mock treatment 307760.0 40600.0 1.08 276560.0 6920.0 0.18 0.8891 0.8115 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P20 mock treatment 318000.0 50800.0 1.35 314880.0 45200.0 1.15 1.7711 0.9967 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P21 mock treatment 307680.0 40500.0 1.08 269440.0 -201.0 -0.01 0.7595 0.7038 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P22 mock treatment 284520.0 17300.0 0.46 258480.0 -11200.0 -0.28 0.1258 0.2322 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P23 mock treatment 251840.0 -15400.0 -0.41 269280.0 -361.0 -0.01 -0.2961 -0.7228 1108.0002 CellTiterGlo(1108.0002) e-CadherinSyntheticLethalAssay 1108.0002.Base P24 mock treatment 250760.0 -16400.0 -0.44 254240.0 -15400.0 -0.39 -0.5869 -0.9984