ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A01 mock treatment 83360.0 -33400.0 -0.28 53640.0 -44800.0 -0.37 -0.4633 -0.9914 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A02 mock treatment 154680.0 37900.0 0.32 95480.0 -2990.0 -0.02 0.2109 0.651 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A03 compound treatment 100960.0 -15800.0 -0.13 138520.0 40000.0 0.33 0.1392 0.3894 985 SPBio_000001 Nc1ccc(C(=O)O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A04 compound treatment 99120.0 -17600.0 -0.15 184440.0 86000.0 0.71 0.3968 0.5459 1408 SPBio_000002 NC1(CC2CC3CC(C2)C1)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A05 compound treatment 72840.0 -43900.0 -0.37 220320.0 122000.0 1.01 0.4484 0.4171 1367 SPBio_000003 Cc1cc(O)ccc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A06 compound treatment 65040.0 -51700.0 -0.44 254880.0 156000.0 1.29 0.6036 0.4417 692 SPBio_000004 CC(=O)Nc1nnc(s1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A07 compound treatment 37040.0 -79700.0 -0.68 283800.0 185000.0 1.53 0.6042 0.3604 1001324 SPBio_000005 OC(=O)CN(CCN(CC(=O)O)CC(=O)O)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A08 compound treatment 61560.0 -55200.0 -0.47 278360.0 180000.0 1.49 0.72 0.4614 2550 SPBio_000006 O[C@@H]([C@@H](COC(=O)CCC(=O)O)NC(=O)C(Cl)Cl)c1ccc(cc1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A09 compound treatment 48440.0 -68300.0 -0.58 276360.0 178000.0 1.47 0.6294 0.3977 3058614 SPBio_000007 C[C@@H](CO)NC(=O)C1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A10 compound treatment 66240.0 -50500.0 -0.43 293400.0 195000.0 1.61 0.8362 0.501 760 SPBio_000008 N[C@@H]1CONC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A11 compound treatment 77720.0 -39000.0 -0.33 386800.0 288000.0 2.39 1.4517 0.6028 3199904 SPBio_000009 OC(=O)c1ccccc1OC(=O)/C=C/C(=O)Oc2ccccc2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A12 compound treatment 155680.0 38900.0 0.33 259160.0 161000.0 1.33 1.1744 0.8572 1267 SPBio_000010 CC(=O)Nc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A13 compound treatment 124760.0 8010.0 0.07 265400.0 167000.0 1.38 1.0247 0.7411 1300 SPBio_000011 OC(=O)c1cccnc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A14 compound treatment 111040.0 -5710.0 -0.05 275360.0 177000.0 1.46 1.0004 0.6833 1001897 SPBio_000012 CC(=O)N[C@@H](CS)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A15 compound treatment 4520.0 -112000.0 -0.96 12480.0 -86000.0 -0.71 -1.1787 -0.9894 3174099 SPBio_000013 Nc1cccc(c1)C(=C2C=CC(=N)C=C2)c3cccc(N)c3.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A16 compound treatment 73000.0 -43700.0 -0.37 259560.0 161000.0 1.33 0.6789 0.4907 1037 SPBio_000014 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A17 compound treatment 60200.0 -56500.0 -0.48 260800.0 162000.0 1.34 0.6091 0.427 1199 SPBio_000015 CSCCC(NC=O)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A18 compound treatment 62960.0 -53800.0 -0.46 249360.0 151000.0 1.25 0.5588 0.4203 1108 SPBio_000016 Cc1cc(=O)n(c2ccccc2)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A19 compound treatment 92280.0 -24500.0 -0.21 241440.0 143000.0 1.18 0.689 0.5737 1096 SPBio_000017 C[N+](C)(C)CC(O)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A20 compound treatment 99080.0 -17700.0 -0.15 219240.0 121000.0 1.0 0.6001 0.594 1132 SPBio_000018 CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A21 compound treatment 6080.0 -111000.0 -0.94 10400.0 -88100.0 -0.73 -1.1815 -0.9919 3059433 SPBio_000019 CC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A22 compound treatment 129280.0 12500.0 0.11 171520.0 73000.0 0.6 0.5028 0.8193 697 SPBio_000020 Cn1c(=O)n(C)c2ncn(CC(O)CO)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A23 mock treatment 127480.0 10700.0 0.09 114240.0 15800.0 0.13 0.1569 0.9849 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 A24 mock treatment 139240.0 22500.0 0.19 44160.0 -54300.0 -0.45 -0.1823 -0.3732 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B01 mock treatment 164240.0 47500.0 0.4 120760.0 22300.0 0.18 0.4163 0.9367 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B02 mock treatment 123880.0 7130.0 0.06 187480.0 89000.0 0.74 0.5636 0.7628 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B03 compound treatment 65920.0 -50800.0 -0.43 121280.0 22800.0 0.19 -0.1726 -0.3656 2060046 SPBio_000021 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)[C@@]4(C)O[C@]43[C@H]2OC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B04 compound treatment 66040.0 -50700.0 -0.43 223640.0 125000.0 1.04 0.4269 0.3805 2060083 SPBio_000022 COC(=O)C(O)[C@H]1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B05 compound treatment 70440.0 -46300.0 -0.39 237320.0 139000.0 1.15 0.5334 0.4392 2060226 SPBio_000023 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cc(cc34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B06 compound treatment 77480.0 -39300.0 -0.33 270720.0 172000.0 1.42 0.7712 0.5269 2060085 SPBio_000024 C[C@]12CCC3[C@@](C)([C@H](O)CC4[C@]3(C)C=CC(=O)OC4(C)C)C25OC5C(=O)O[C@H]1c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B07 compound treatment 44600.0 -72100.0 -0.61 264880.0 166000.0 1.38 0.5391 0.3576 2060422 SPBio_000025 CCOc1ccc(cc1)C(=O)c2cc(O)c(OC)c(OC)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B08 compound treatment 39560.0 -77200.0 -0.66 299120.0 201000.0 1.66 0.709 0.3972 2069252 SPBio_000026 CCC(C)C(OC(=O)C)C(=O)O[C@H]1[C@H](OC=O)C(C(=C)C2(O)C(=O)C[C@@H](c3ccoc3)[C@]12C)[C@]4(C)C(CC(=O)OC)[C@@](C)(COC(=O)C)OC(=O)C[C@@H]4OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B09 compound treatment 35360.0 -81400.0 -0.69 287720.0 189000.0 1.57 0.6171 0.3604 2060223 SPBio_000027 COc1cc(OC)c2C[C@H](O)[C@H](Oc2c1)c3ccc(OC)c(OC)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B10 compound treatment 56200.0 -60500.0 -0.52 282040.0 184000.0 1.52 0.7093 0.4423 2060087 SPBio_000028 COC(=O)C(O)[C@H]1C(C)(C)C(OC(=O)/C(=C/C)/C)[C@@H]2C=C3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B11 compound treatment 156520.0 39800.0 0.34 303680.0 205000.0 1.7 1.4399 0.8318 2060224 SPBio_000029 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4ccc(O)c(O)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B12 compound treatment 172800.0 56100.0 0.48 233760.0 135000.0 1.12 1.1289 0.9278 2060090 SPBio_000030 COC(=O)C[C@H]1C(C)(C)C(OC(=O)C)[C@]2(O)C=C3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B13 compound treatment 154800.0 38100.0 0.32 268440.0 170000.0 1.41 1.2234 0.8478 2060169 SPBio_000031 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4c5c(O)c(O)c(O)cc5[C@H]6Oc7cc(O)cc(O)c7C[C@H]6OC(=O)c8cc(O)c(O)c(O)c8 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B14 compound treatment 108080.0 -8670.0 -0.07 278080.0 180000.0 1.49 0.9985 0.6712 2060089 SPBio_000032 CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@@H](OC(=O)CC32OC4(C)O[C@]53[C@H](OC(=O)C)[C@@]6(O)C(OC(=O)C7(C)OC7C)C8(C)CC6(O)[C@@](C)([C@H]8CC(=O)OC)[C@@]15O4)c9ccoc9 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B15 compound treatment 72560.0 -44200.0 -0.38 300600.0 202000.0 1.67 0.9164 0.5347 1254 SPBio_000033 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B16 compound treatment 5800.0 -111000.0 -0.94 17720.0 -80800.0 -0.67 -1.1403 -0.9856 2060091 SPBio_000034 CC(CC(O)C1OC1(C)C)[C@@H]2CCC3(C)C4=CCC5C(C)(C)C(=O)CCC5(C)C4CC[C@@]23C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B17 compound treatment 50000.0 -66700.0 -0.57 283360.0 185000.0 1.53 0.6797 0.4166 1859 SPBio_000035 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c(O)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B18 compound treatment 5200.0 -112000.0 -0.95 17520.0 -81000.0 -0.67 -1.1451 -0.9854 2060093 SPBio_000036 CC([C@@H]1CC[C@]2(C)C3=CCC4C(C)(C)C(=O)CC[C@]4(C)C3CC[C@@]12C)C5OC(C)(C)C(O)C5O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B19 compound treatment 33480.0 -83300.0 -0.71 102640.0 4170.0 0.03 -0.4769 -0.6719 2060218 SPBio_000037 COc1c(CC(=O)c2cc3CC(O)C(C)(C)Oc3cc2O)ccc4OC(C)(C)C=Cc14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B20 compound treatment 74960.0 -41800.0 -0.36 253760.0 155000.0 1.28 0.6568 0.4927 2060094 SPBio_000038 COC(=O)C(O)[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B21 compound treatment 6280.0 -110000.0 -0.94 13960.0 -84500.0 -0.7 -1.1594 -0.9893 3054028 SPBio_000039 CC(CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=C(CC[C@@]12C)C4(C)CC[C@H](O)C(C)(C)C4CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B22 compound treatment 127640.0 10900.0 0.09 221120.0 123000.0 1.01 0.783 0.7685 2060115 SPBio_000040 CC(=CCOc1cc2oc(=O)ccc2cc1O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B23 mock treatment 148400.0 31700.0 0.27 221400.0 123000.0 1.02 0.9097 0.8647 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 B24 mock treatment 146800.0 30100.0 0.26 78360.0 -20100.0 -0.17 0.0633 0.2074 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C01 mock treatment 97320.0 -19400.0 -0.17 124200.0 25700.0 0.21 0.0335 0.1245 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C02 mock treatment 108960.0 -7790.0 -0.07 203600.0 105000.0 0.87 0.5681 0.6513 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C03 compound treatment 74120.0 -42600.0 -0.36 171120.0 72600.0 0.6 0.1683 0.2398 2069233 SPBio_000041 COc1ccc2C3CCC4(C)C(O)[C@H](O)CC4C3CCc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C04 compound treatment 70040.0 -46700.0 -0.4 151000.0 52500.0 0.43 0.0261 0.0443 844 SPBio_000042 CNCCCN1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C05 compound treatment 28160.0 -88600.0 -0.75 97280.0 -1190.0 -0.01 -0.5403 -0.7163 2069241 SPBio_000043 COc1ccc2C3CC[C@]4(C)[C@@H](O)CCC4C3CCc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C06 compound treatment 95960.0 -20800.0 -0.18 285160.0 187000.0 1.54 0.9669 0.622 678 SPBio_000044 NCC(CC(=O)O)c1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C07 compound treatment 56200.0 -60500.0 -0.52 270280.0 172000.0 1.42 0.6405 0.4236 1094519 SPBio_000045 CC(=O)N1CCCC1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C08 compound treatment 45720.0 -71000.0 -0.6 274400.0 176000.0 1.46 0.6015 0.3817 1469 SPBio_000046 CCC1(CCC(=O)NC1=O)c2ccc(N)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C09 compound treatment 44040.0 -72700.0 -0.62 274240.0 176000.0 1.45 0.5905 0.3736 736 SPBio_000047 COC(=O)C(N)CS 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C10 compound treatment 53360.0 -63400.0 -0.54 271680.0 173000.0 1.43 0.6316 0.4125 1000124 SPBio_000048 CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C11 compound treatment 65880.0 -50900.0 -0.43 299480.0 201000.0 1.66 0.8696 0.5061 978 SPBio_000049 COC(=O)C(C)C[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C12 compound treatment 197200.0 80500.0 0.69 321320.0 223000.0 1.84 1.788 0.9091 997 SPBio_000050 NCc1ccc(cc1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C13 compound treatment 205440.0 88700.0 0.76 296920.0 198000.0 1.64 1.6948 0.9379 2069271 SPBio_000051 C[C@H](N)[C@H](O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C14 compound treatment 124000.0 7250.0 0.06 301080.0 203000.0 1.68 1.2289 0.7327 1252 SPBio_000052 CC(C)NCC(O)c1cc(O)cc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C15 compound treatment 54600.0 -62100.0 -0.53 217520.0 119000.0 0.98 0.3222 0.2882 1404 SPBio_000053 Nc1ccc(N=Nc2ccccc2)c(N)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C16 compound treatment 6280.0 -110000.0 -0.94 52000.0 -46500.0 -0.38 -0.9369 -0.9221 1485 SPBio_000054 CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C17 compound treatment 45960.0 -70800.0 -0.6 281760.0 183000.0 1.52 0.646 0.3959 1090918 SPBio_000055 Cc1nc(C)c(Cl)c(O)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C18 compound treatment 57120.0 -59600.0 -0.51 227920.0 129000.0 1.07 0.3983 0.336 1292 SPBio_000056 O=c1[nH]cnc2[nH]ncc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C19 compound treatment 75320.0 -41400.0 -0.35 252760.0 154000.0 1.28 0.6531 0.4932 3182 SPBio_000057 CCCc1cc(ccn1)C(=S)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C20 compound treatment 72040.0 -44700.0 -0.38 255040.0 157000.0 1.3 0.6467 0.479 1332 SPBio_000058 NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C21 compound treatment 77680.0 -39100.0 -0.33 221160.0 123000.0 1.01 0.4825 0.4517 3199905 SPBio_000059 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4c5nc6cc(C)ccn6c5c(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)C(O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)c(O)c4c(O)c3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C22 compound treatment 68720.0 -48000.0 -0.41 198280.0 99800.0 0.83 0.2947 0.3198 3177311 SPBio_000060 C[C@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C23 mock treatment 121920.0 5170.0 0.04 138360.0 39900.0 0.33 0.2645 0.7945 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 C24 mock treatment 130920.0 14200.0 0.12 55240.0 -43200.0 -0.36 -0.1676 -0.4439 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D01 mock treatment 80280.0 -36500.0 -0.31 129280.0 30800.0 0.25 -0.0393 -0.0979 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D02 mock treatment 61160.0 -55600.0 -0.47 141040.0 42600.0 0.35 -0.0856 -0.1452 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D03 compound treatment 64560.0 -52200.0 -0.44 119760.0 21300.0 0.18 -0.1897 -0.3968 2069246 SPBio_000061 Cc1cc(O)c(C=O)c2Oc3c4C(O)OC(=O)c4c(O)c(C)c3OC(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D04 compound treatment 91680.0 -25100.0 -0.21 215560.0 117000.0 0.97 0.534 0.5384 2060364 SPBio_000062 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D05 compound treatment 30240.0 -86500.0 -0.74 62920.0 -35600.0 -0.29 -0.7288 -0.9189 3198309 SPBio_000063 CC(=O)OCC(O)CC(O)CCCCCCCCCCCC=C.CC(=O)OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D06 compound treatment 133880.0 17100.0 0.15 287960.0 189000.0 1.57 1.2116 0.7696 2060372 SPBio_000064 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3=C(CC[C@@]4(C)[C@@H](OC(=O)C=C34)c5ccoc5)[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D07 compound treatment 57040.0 -59700.0 -0.51 261000.0 163000.0 1.34 0.5913 0.4113 2060203 SPBio_000065 CCOC(=O)c1c(C)cc(O)c(C)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D08 compound treatment 56800.0 -59900.0 -0.51 225560.0 127000.0 1.05 0.3825 0.3273 2060145 SPBio_000066 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)C=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D09 compound treatment 70560.0 -46200.0 -0.39 267120.0 169000.0 1.4 0.7085 0.4888 2060100 SPBio_000067 OC(=O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D10 compound treatment 97240.0 -19500.0 -0.17 257440.0 159000.0 1.32 0.8125 0.6129 2060127 SPBio_000068 COC1CC2=C3C[C@H]4C(=O)C(C)(C)[C@H](CC(=O)OC)[C@@](C)(C3CC[C@@]2(C)[C@@H](O1)c5ccoc5)C4=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D11 compound treatment 12000.0 -105000.0 -0.89 25680.0 -72800.0 -0.6 -1.0564 -0.9817 1017609 SPBio_000069 CC(=CCc1c(O)c2c(=O)c(coc2c3C=CC(C)(C)Oc13)c4ccc(O)cc4)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D12 compound treatment 226120.0 109000.0 0.93 278960.0 180000.0 1.49 1.7143 0.9742 2060118 SPBio_000070 COC(=O)CC1C(C)(C)C(O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D13 compound treatment 20800.0 -95900.0 -0.82 46320.0 -52200.0 -0.43 -0.8827 -0.9555 2069330 SPBio_000071 COc1cc(O)c(C(=O)/C=C/c2ccccc2)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D14 compound treatment 121160.0 4410.0 0.04 294480.0 196000.0 1.62 1.1732 0.7233 2060121 SPBio_000072 COC(=O)C[C@H]1C(C)(C)C2(Cl)O[C@]34CC2C(=O)[C@]1(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C35)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D15 compound treatment 110480.0 -6270.0 -0.05 302920.0 204000.0 1.69 1.1582 0.6845 2060495 SPBio_000073 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3c4c(O)c(O)c(O)cc4[C@H]5Oc6cc(O)cc(O)c6C[C@H]5OC(=O)c7cc(O)c(O)c(O)c7 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D16 compound treatment 69960.0 -46800.0 -0.4 259800.0 161000.0 1.33 0.662 0.4753 2060150 SPBio_000074 CC1(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]3(C)OC(=O)CC12)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D17 compound treatment 13520.0 -103000.0 -0.88 21880.0 -76600.0 -0.63 -1.0695 -0.9871 3173879 SPBio_000075 CC(=CCc1c2OC(C)(C)C=Cc2c(OC(=O)C)c3c(=O)c(OC(=O)C)c(oc13)c4ccccc4)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D18 compound treatment 62760.0 -54000.0 -0.46 188280.0 89800.0 0.74 0.2003 0.2293 2060154 SPBio_000076 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D19 compound treatment 106760.0 -9990.0 -0.09 155360.0 56900.0 0.47 0.2727 0.5701 3054809 SPBio_000077 COc1ccc2C(=O)C(Cc3ccc(OC)c(OC(=O)C)c3)COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D20 compound treatment 81160.0 -35600.0 -0.3 158040.0 59600.0 0.49 0.1342 0.232 2060037 SPBio_000078 CC(=O)O[C@@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D21 compound treatment 60560.0 -56200.0 -0.48 235720.0 137000.0 1.14 0.4646 0.3771 2060139 SPBio_000079 COc1ccc([C@@H]2COc3c(OC)c(OC)ccc3C2)c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D22 compound treatment 52160.0 -64600.0 -0.55 137160.0 38700.0 0.32 -0.1625 -0.2554 2060350 SPBio_000080 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D23 mock treatment 91320.0 -25400.0 -0.22 184120.0 85600.0 0.71 0.3479 0.4696 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 D24 mock treatment 93000.0 -23700.0 -0.2 66520.0 -32000.0 -0.26 -0.3299 -0.9912 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E01 mock treatment 55880.0 -60900.0 -0.52 199600.0 101000.0 0.84 0.2251 0.2288 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E02 mock treatment 56120.0 -60600.0 -0.52 98400.0 -72.5 0.0 -0.3654 -0.7079 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E03 compound treatment 78560.0 -38200.0 -0.33 150320.0 51800.0 0.43 0.0734 0.1364 1014792 SPBio_000081 OC(=O)c1cc2ccccc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E04 compound treatment 44440.0 -72300.0 -0.62 101360.0 2890.0 0.02 -0.4184 -0.6792 1365 SPBio_000082 CN(C)CCC=C1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E05 compound treatment 182800.0 66100.0 0.56 252800.0 154000.0 1.28 1.3004 0.9322 3173210 SPBio_000083 CO/N=C(\C(=O)NC1[C@H]2SCC(=C(N2C1=O)C(=O)O)CSc3nc(=O)c(=O)[nH]n3C)/c4csc(N)n4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E06 compound treatment 189320.0 72600.0 0.62 275680.0 177000.0 1.47 1.4735 0.9262 3173722 SPBio_000084 NCC[C@@H](O)C(=O)N[C@@H]1C[C@H](N)[C@@H](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)C3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E07 compound treatment 81640.0 -35100.0 -0.3 266240.0 168000.0 1.39 0.77 0.5424 1310 SPBio_000085 NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H]([C@H](OP(=O)(O)O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E08 compound treatment 97960.0 -18800.0 -0.16 275480.0 177000.0 1.46 0.9223 0.6261 712 SPBio_000086 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSc3ccncc3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E09 compound treatment 12080.0 -105000.0 -0.89 25600.0 -72900.0 -0.6 -1.0564 -0.9819 1010201 SPBio_000087 ClC1=C(Cl)C(=O)C(=C(Cl)C1=O)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E10 compound treatment 130480.0 13700.0 0.12 293800.0 195000.0 1.62 1.2253 0.7563 679 SPBio_000088 CC(=O)Nc1cc(ccc1O)[As](=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E11 compound treatment 16720.0 -100000.0 -0.85 51280.0 -47200.0 -0.39 -0.8783 -0.9374 193 SPBio_000089 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E12 compound treatment 262600.0 146000.0 1.24 303960.0 205000.0 1.7 2.0802 0.9881 995 SPBio_000090 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@@H]([C@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E13 compound treatment 255800.0 139000.0 1.18 309760.0 211000.0 1.75 2.0731 0.982 2801 SPBio_000091 CCCCCCNC(=O)n1cc(F)c(=O)[nH]c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E14 compound treatment 62800.0 -53900.0 -0.46 131760.0 33300.0 0.28 -0.1301 -0.2429 1141 SPBio_000092 CN1C2CCC1CC(C2)OC(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E15 compound treatment 149000.0 32300.0 0.27 285640.0 187000.0 1.55 1.2891 0.8197 3199906 SPBio_000093 CC[C@H]1OC(=O)C[C@@H](O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C(=C/[C@@H]1CO[C@@H]4O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]4OC)/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E16 compound treatment 144680.0 27900.0 0.24 290600.0 192000.0 1.59 1.2921 0.804 735 SPBio_000094 NNC(=O)c1ccncc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E17 compound treatment 101400.0 -15300.0 -0.13 296720.0 198000.0 1.64 1.0673 0.6487 2069298 SPBio_000095 CC(=O)Nc1c(I)cc(I)c(C(=O)O)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E18 compound treatment 102960.0 -13800.0 -0.12 250640.0 152000.0 1.26 0.8071 0.6384 1519 SPBio_000096 CC1(C)OC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E19 compound treatment 86800.0 -29900.0 -0.25 222000.0 124000.0 1.02 0.5423 0.5149 3173493 SPBio_000097 CC1=C2CCC3C4CCC(=O)[C@@]4(C)CCC3[C@@]2(C)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E20 compound treatment 142960.0 26200.0 0.22 279600.0 181000.0 1.5 1.2174 0.8036 1414 SPBio_000098 CC(=O)NO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E21 compound treatment 45200.0 -71500.0 -0.61 64920.0 -33600.0 -0.28 -0.627 -0.9367 1467 SPBio_000099 CCCCOc1ccc(OCCCN2CCOCC2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E22 compound treatment 50800.0 -65900.0 -0.56 128800.0 30300.0 0.25 -0.2196 -0.3571 1035 SPBio_000100 Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E23 mock treatment 105320.0 -11400.0 -0.1 187640.0 89200.0 0.74 0.4528 0.6086 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 E24 mock treatment 73360.0 -43400.0 -0.37 108680.0 10200.0 0.08 -0.2015 -0.5317 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F01 mock treatment 51960.0 -64800.0 -0.55 200480.0 102000.0 0.84 0.2067 0.205 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F02 mock treatment 68720.0 -48000.0 -0.41 139640.0 41200.0 0.34 -0.0483 -0.0908 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F03 compound treatment 67680.0 -49100.0 -0.42 91200.0 -7270.0 -0.06 -0.3379 -0.8007 3173749 SPBio_000101 COc1cc2OC[C@H]3Oc4c5CC(Oc5ccc4C(=O)[C@H]3c2cc1OC)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F04 compound treatment 11720.0 -105000.0 -0.89 15080.0 -83400.0 -0.69 -1.1201 -0.9918 2060160 SPBio_000102 CC(=O)O[C@@H]1CC2C(C)(C)CCC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F05 compound treatment 183720.0 67000.0 0.57 237080.0 139000.0 1.15 1.214 0.948 1008719 SPBio_000103 COC(=O)C(O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F06 compound treatment 213080.0 96300.0 0.82 288200.0 190000.0 1.57 1.6898 0.9542 2060129 SPBio_000104 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F07 compound treatment 100200.0 -16500.0 -0.14 238280.0 140000.0 1.16 0.7182 0.6164 2060163 SPBio_000105 COc1ccc2C(=O)[C@@H]3[C@@H](COc4cc(OC)c(OC)cc34)Oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F08 compound treatment 102720.0 -14000.0 -0.12 275840.0 177000.0 1.47 0.9531 0.6474 2060365 SPBio_000106 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C3OC3[C@]2(C)C4CC[C@@]5(C)[C@@H](OC(=O)C6OC65[C@]14C)c7ccoc7 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F09 compound treatment 119640.0 2890.0 0.02 222840.0 124000.0 1.03 0.7449 0.7238 2060165 SPBio_000107 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F10 compound treatment 183040.0 66300.0 0.56 303760.0 205000.0 1.7 1.6 0.894 2060162 SPBio_000108 COC(=O)C[C@H]1C(C)(C)[C@@H](O)[C@@H]2CC3=C4C=C(OC)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F11 compound treatment 232000.0 115000.0 0.98 278720.0 180000.0 1.49 1.7483 0.9794 1372522 SPBio_000109 COc1ccc(cc1)c2coc3cc(OC)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F12 compound treatment 265440.0 149000.0 1.27 311160.0 213000.0 1.76 2.1394 0.987 2060177 SPBio_000110 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]2(C)[C@H]7O[C@H]7C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F13 compound treatment 230800.0 114000.0 0.97 344240.0 246000.0 2.03 2.1243 0.9428 2069309 SPBio_000111 COc1cc2OC[C@H]3Oc4c5CCC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F14 compound treatment 197040.0 80300.0 0.68 272080.0 174000.0 1.44 1.499 0.9424 2060320 SPBio_000112 COc1ccc2CC[C@@H]3CC(=O)CC[C@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F15 compound treatment 183640.0 66900.0 0.57 287640.0 189000.0 1.56 1.5093 0.9063 2060494 SPBio_000113 COc1ccc2C(=O)C(Cc3ccc(OC)c(OC)c3)COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F16 compound treatment 13400.0 -103000.0 -0.88 22320.0 -76200.0 -0.63 -1.0677 -0.9866 3173369 SPBio_000114 CC(C)c1c(OC(=O)C)ccc2c1CCC3C(C)(C)CCC[C@@]32C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F17 compound treatment 122920.0 6170.0 0.05 270320.0 172000.0 1.42 1.0424 0.7328 2060110 SPBio_000115 COc1ccc(c(OC)c1)c2coc3cc(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F18 compound treatment 11040.0 -106000.0 -0.9 19120.0 -79400.0 -0.66 -1.1006 -0.988 2060034 SPBio_000116 CC(C)c1c(O)ccc2c1CCC3[C@](C)(CCC[C@@]32C)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F19 compound treatment 67160.0 -49600.0 -0.42 105760.0 7290.0 0.06 -0.2559 -0.6 2060102 SPBio_000117 COc1ccc2C(=O)c3cc(OC)c(OC)cc3CC(=O)COc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F20 compound treatment 46520.0 -70200.0 -0.6 39880.0 -58600.0 -0.48 -0.7655 -0.9946 2060126 SPBio_000118 CC(C)c1c(O)ccc2c1CCC3[C@@](C)(CO)CCC[C@@]32C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F21 compound treatment 144840.0 28100.0 0.24 227320.0 129000.0 1.07 0.9229 0.8448 1059133 SPBio_000119 COc1ccc(C(=O)c2ccccc2)c(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F22 compound treatment 45320.0 -71400.0 -0.61 62720.0 -35800.0 -0.3 -0.6392 -0.9452 3053987 SPBio_000120 CC(=O)C1CC[C@H]2C3CC[C@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F23 mock treatment 97440.0 -19300.0 -0.16 150160.0 51700.0 0.43 0.1861 0.4063 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 F24 mock treatment 60160.0 -56600.0 -0.48 70840.0 -27600.0 -0.23 -0.5023 -0.942 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G01 mock treatment 77200.0 -39500.0 -0.34 111080.0 12600.0 0.1 -0.1643 -0.4662 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G02 mock treatment 52400.0 -64300.0 -0.55 134040.0 35600.0 0.29 -0.1793 -0.2884 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G03 compound treatment 115160.0 -1590.0 -0.01 161760.0 63300.0 0.52 0.3607 0.6886 2060144 SPBio_000121 COc1cccc(c1)c2cc(=O)c3cc(OC)ccc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G04 compound treatment 198120.0 81400.0 0.69 267920.0 169000.0 1.4 1.4811 0.9472 696 SPBio_000122 Oc1cccc2Cc3cccc(O)c3C(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G05 compound treatment 206440.0 89700.0 0.76 246240.0 148000.0 1.22 1.4044 0.9743 3077146 SPBio_000123 CN[C@@H]1[C@@H](O)C(OC2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](C(C)O)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)OC[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G06 compound treatment 211680.0 94900.0 0.81 270160.0 172000.0 1.42 1.5759 0.9643 1124 SPBio_000124 CN1C2CC[C@@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G07 compound treatment 155200.0 38500.0 0.33 277760.0 179000.0 1.48 1.2803 0.8429 3077147 SPBio_000125 CC(O)Cn1c(C)ncc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G08 compound treatment 15840.0 -101000.0 -0.86 24840.0 -73600.0 -0.61 -1.0382 -0.9858 1247 SPBio_000126 Oc1c(Cl)cc(Cl)cc1Sc2cc(Cl)cc(Cl)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G09 compound treatment 239240.0 122000.0 1.04 320960.0 222000.0 1.84 2.039 0.9638 1461079 SPBio_000127 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCN(C)CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G10 compound treatment 243320.0 127000.0 1.08 294800.0 196000.0 1.62 1.9105 0.9802 1327 SPBio_000128 C[N+](C)(C)CCOC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G11 compound treatment 21520.0 -95200.0 -0.81 27120.0 -71400.0 -0.59 -0.9907 -0.9878 3480340 SPBio_000129 c1cn(cn1)C(c2ccccc2)c3ccc(cc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G12 compound treatment 219040.0 102000.0 0.87 242560.0 144000.0 1.19 1.4587 0.9881 1432 SPBio_000130 CN(C)CCOC(C)(c1ccccc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G13 compound treatment 270080.0 153000.0 1.31 332760.0 234000.0 1.94 2.2937 0.9815 3199907 SPBio_000131 OC(=O)c1cn(c2ccc(F)cc2)c3cc(N4CCNCC4)c(F)cc3c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G14 compound treatment 241360.0 125000.0 1.06 310000.0 212000.0 1.75 1.9876 0.9713 873 SPBio_000132 Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CNc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G15 compound treatment 121840.0 5090.0 0.04 139000.0 40500.0 0.34 0.2677 0.792 1007083 SPBio_000133 Oc1cc(O)c2C(=O)c3ccccc3C(=O)c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G16 compound treatment 143120.0 26400.0 0.22 191600.0 93100.0 0.77 0.7036 0.8767 1513 SPBio_000134 CCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G17 compound treatment 183560.0 66800.0 0.57 220640.0 122000.0 1.01 1.1169 0.963 1008492 SPBio_000135 O=C(CC(=O)c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G18 compound treatment 180480.0 63700.0 0.54 252920.0 154000.0 1.28 1.2872 0.9273 1000042 SPBio_000136 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G19 compound treatment 243160.0 126000.0 1.08 277160.0 179000.0 1.48 1.8063 0.9878 3480338 SPBio_000137 OC(=O)C(Cc1cc(=O)[nH]c2ccccc12)NC(=O)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G20 compound treatment 205080.0 88300.0 0.75 240960.0 142000.0 1.18 1.3653 0.9764 3172713 SPBio_000138 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C)\c3csc(N)n3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G21 compound treatment 107480.0 -9270.0 -0.08 120040.0 21600.0 0.18 0.0704 0.3608 903 SPBio_000139 COC(=O)Nc1nc2ccc(Sc3ccccc3)cc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G22 compound treatment 124400.0 7650.0 0.07 221280.0 123000.0 1.02 0.7645 0.7509 1336 SPBio_000140 CC1(C)S[C@@H]2[C@H](NC(=O)C(C(=O)O)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G23 mock treatment 100480.0 -16300.0 -0.14 180200.0 81700.0 0.68 0.3802 0.5508 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 G24 mock treatment 62800.0 -53900.0 -0.46 50440.0 -48000.0 -0.4 -0.6058 -0.9974 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H01 mock treatment 94600.0 -22100.0 -0.19 69600.0 -28900.0 -0.24 -0.3022 -0.9931 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H02 mock treatment 74720.0 -42000.0 -0.36 101400.0 2930.0 0.02 -0.2359 -0.6577 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H03 compound treatment 84000.0 -32700.0 -0.28 136480.0 38000.0 0.31 0.0252 0.0599 2060106 SPBio_000141 COc1cc(cc(OC)c1OC)c2coc3cc(OC)c(OC)c(OC)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H04 compound treatment 13840.0 -103000.0 -0.88 15480.0 -83000.0 -0.69 -1.105 -0.9927 3173992 SPBio_000142 CC(C)c1c(O)ccc2c1CCC3C(C)(C)CCC[C@@]32C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H05 compound treatment 185080.0 68300.0 0.58 233960.0 135000.0 1.12 1.204 0.9534 3054981 SPBio_000143 COc1ccc(cc1)c2cc(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H06 compound treatment 212080.0 95300.0 0.81 276160.0 178000.0 1.47 1.6134 0.9608 2060280 SPBio_000144 C[C@H]1C2C(CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4CC[C@]23C)OC(=O)C)O[C@]61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H07 compound treatment 84320.0 -32400.0 -0.28 135560.0 37100.0 0.31 0.0217 0.0527 3054030 SPBio_000145 Oc1cc(O)cc(/C=C/c2ccccc2)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H08 compound treatment 203160.0 86400.0 0.74 260200.0 162000.0 1.34 1.4663 0.9603 3174366 SPBio_000146 C[C@H]1C2C(CC3C4CC[C@@H]5C[C@H](CC[C@]5(C)C4CC[C@]23C)OC(=O)C)O[C@]61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H09 compound treatment 219560.0 103000.0 0.88 249760.0 151000.0 1.25 1.504 0.9847 3055207 SPBio_000147 COc1cc(O)cc(/C=C/c2ccccc2)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H10 compound treatment 228960.0 112000.0 0.96 261280.0 163000.0 1.35 1.628 0.9859 2060351 SPBio_000148 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4=CC(=O)[C@]23C)OC(=O)C)OC61OCC(C)CC6Br 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H11 compound treatment 273920.0 157000.0 1.34 274080.0 176000.0 1.45 1.9735 0.9992 3054032 SPBio_000149 COc1cc(C/C=C/c2ccccc2)c(OC)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H12 compound treatment 319320.0 203000.0 1.72 253920.0 155000.0 1.29 2.1289 0.9895 2060188 SPBio_000150 C[C@H]1C2C(CC3C4CCC5C[C@@H](O)CCC5(C)C4=CCC23C)OC61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H13 compound treatment 270520.0 154000.0 1.31 292880.0 194000.0 1.61 2.063 0.9948 2060259 SPBio_000151 COc1ccc2c(=O)c(CC(=O)O)coc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H14 compound treatment 276240.0 159000.0 1.36 269440.0 171000.0 1.41 1.9603 0.9998 3173999 SPBio_000152 C[C@H]1C2C(CC3C4CC[C@H]5CC(CCC5(C)C4CC(=O)C23C)OC(=O)C)OC61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H15 compound treatment 148960.0 32200.0 0.27 166920.0 68400.0 0.57 0.5943 0.9446 2060294 SPBio_000153 COc1ccc2C(=O)C(Cc3ccc(OC)c(O)c3)COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H16 compound treatment 235240.0 118000.0 1.01 250600.0 152000.0 1.26 1.6033 0.994 3054097 SPBio_000154 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H17 compound treatment 218160.0 101000.0 0.86 269640.0 171000.0 1.42 1.6118 0.9719 2060133 SPBio_000155 COc1cc(cc(O)c1OC)c2coc3cc(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(O)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H18 compound treatment 14440.0 -102000.0 -0.87 17000.0 -81500.0 -0.67 -1.0925 -0.992 3173995 SPBio_000156 C[C@H]1C2C(O[C@@]31CC[C@@H](C)CO3)C(O)C4C5CC[C@H]6C[C@H](O[C@@H]7O[C@H](CO)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O[C@@H]9OC[C@@H](O)[C@H](O)[C@H]9O)[C@H]8O[C@@H]%10O[C@H](CO)[C@H](O)[C@H](O[C@@H]%11O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%11O)[C@H]%10O)[C@H](O)[C@H]7O)[C@H](O)C[C@]6(C)C5CC[C@]24C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H19 compound treatment 244160.0 127000.0 1.08 272800.0 174000.0 1.44 1.7869 0.9902 3054129 SPBio_000157 CO[C@@H]1CC2N3CC(O)C2(C=C1)c4cc5OCOc5c(OC)c4C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H20 compound treatment 223680.0 107000.0 0.91 223400.0 125000.0 1.03 1.3746 0.998 1355 SPBio_000158 CC(C)(O)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@@]53C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H21 compound treatment 85320.0 -31400.0 -0.27 155400.0 56900.0 0.47 0.1438 0.2655 2060069 SPBio_000159 COc1cc(cc(O)c1OC)c2coc3cc(OCc4ccccc4)c(OC)c(O)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H22 compound treatment 117960.0 1210.0 0.01 163160.0 64700.0 0.54 0.3857 0.7206 2060207 SPBio_000160 CC1(C)[C@H](O)C[C@H](O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H23 mock treatment 117280.0 534.0 0.0 180840.0 82400.0 0.68 0.485 0.7118 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 H24 mock treatment 66960.0 -49800.0 -0.42 38120.0 -60400.0 -0.5 -0.6528 -0.9967 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I01 mock treatment 98480.0 -18300.0 -0.16 54200.0 -44300.0 -0.37 -0.3689 -0.9272 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I02 mock treatment 110840.0 -5910.0 -0.05 102640.0 4170.0 0.03 -0.0112 -0.1833 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I03 compound treatment 139200.0 22500.0 0.19 165840.0 67400.0 0.56 0.5293 0.8983 2060260 SPBio_000161 COc1ccc(cc1)C2CC(=O)c3ccc(OC)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I04 compound treatment 154560.0 37800.0 0.32 163760.0 65300.0 0.54 0.6096 0.9694 759 SPBio_000162 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I05 compound treatment 206360.0 89600.0 0.76 224600.0 126000.0 1.04 1.2773 0.9882 2335 SPBio_000163 COc1ccc(/C=C/C(=O)Nc2ccccc2C(=O)O)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I06 compound treatment 231320.0 115000.0 0.98 252160.0 154000.0 1.27 1.5888 0.9914 807 SPBio_000164 CCCc1ncc(C[n+]2ccccc2C)c(N)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I07 compound treatment 233480.0 117000.0 0.99 278040.0 180000.0 1.49 1.7532 0.9809 1025940 SPBio_000165 Cc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I08 compound treatment 249040.0 132000.0 1.13 239600.0 141000.0 1.17 1.622 0.9998 1381 SPBio_000166 Nc1ccc(cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I09 compound treatment 203600.0 86900.0 0.74 165800.0 67300.0 0.56 0.9168 0.9902 2516 SPBio_000167 CC(C)OC(=O)Nc1cccc(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I10 compound treatment 316080.0 199000.0 1.7 271880.0 173000.0 1.43 2.2145 0.9965 1303 SPBio_000168 C[N+]1(CCC2CC1)CC2OC(=O)C(O)(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I11 compound treatment 265520.0 149000.0 1.27 251560.0 153000.0 1.27 1.7912 1.0 2069315 SPBio_000169 COc1cc(OC)c2c(=O)c(coc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I12 compound treatment 313160.0 196000.0 1.67 272000.0 174000.0 1.44 2.1976 0.9971 1019 SPBio_000170 NC(=O)N1c2ccccc2C=Cc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I13 compound treatment 90880.0 -25900.0 -0.22 85360.0 -13100.0 -0.11 -0.2324 -0.9468 2060112 SPBio_000171 COc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I14 compound treatment 148560.0 31800.0 0.27 32880.0 -65600.0 -0.54 -0.1922 -0.3168 1400 SPBio_000172 CC(C)[C@@H](C)/C=C/[C@@H](C)C1CC[C@H]2\C(=C\C=C/3\C[C@@H](O)CCC3=C)\CCC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I15 compound treatment 103640.0 -13100.0 -0.11 52160.0 -46300.0 -0.38 -0.3498 -0.8766 1602 SPBio_000173 COc1ccc(cc1)c2coc3cc(O)cc(O)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I16 compound treatment 228680.0 112000.0 0.95 174080.0 75600.0 0.63 1.1162 0.9791 1000114 SPBio_000174 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I17 compound treatment 15400.0 -101000.0 -0.86 13760.0 -84700.0 -0.7 -1.1057 -0.9947 2069308 SPBio_000175 CC(=CCc1c(O)cc2occ(c3ccc4OCOc4c3)c(=O)c2c1O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I18 compound treatment 34640.0 -82100.0 -0.7 11600.0 -86900.0 -0.72 -1.0025 -0.9999 1272 SPBio_000176 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I19 compound treatment 194000.0 77300.0 0.66 160760.0 62300.0 0.52 0.8295 0.9927 1534 SPBio_000177 O=C(/C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I20 compound treatment 182960.0 66200.0 0.56 220200.0 122000.0 1.01 1.1107 0.9624 1000138 SPBio_000178 CC(C)Cc1ccc(cc1)C(C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I21 compound treatment 119120.0 2370.0 0.02 120440.0 22000.0 0.18 0.1428 0.7809 2060354 SPBio_000179 COc1ccc(cc1)c2coc3cc(OC(=O)C)cc(OC(=O)C)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I22 compound treatment 35600.0 -81100.0 -0.69 70160.0 -28300.0 -0.23 -0.6542 -0.8967 1157 SPBio_000180 CC(=O)N1CCN(CC1)c2ccc(OCC3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I23 mock treatment 109480.0 -7270.0 -0.06 161800.0 63300.0 0.52 0.3267 0.6193 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 I24 mock treatment 93320.0 -23400.0 -0.2 41360.0 -57100.0 -0.47 -0.4751 -0.9264 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J01 mock treatment 163040.0 46300.0 0.39 46440.0 -52000.0 -0.43 -0.0257 -0.044 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J02 mock treatment 93080.0 -23700.0 -0.2 104000.0 5530.0 0.05 -0.1101 -0.5331 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J03 compound treatment 58720.0 -58000.0 -0.49 48480.0 -50000.0 -0.41 -0.6418 -0.9961 2120750 SPBio_000181 CC(C)C(C)/C=C/C(C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J04 compound treatment 185320.0 68600.0 0.58 165520.0 67000.0 0.55 0.8051 0.9997 2060212 SPBio_000182 CC1(C)[C@H](O)CC(=O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J05 compound treatment 216280.0 99500.0 0.85 216360.0 118000.0 0.98 1.2889 0.9976 2060070 SPBio_000183 COc1c(O)cc(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J06 compound treatment 51080.0 -65700.0 -0.56 44400.0 -54100.0 -0.45 -0.7116 -0.9939 3054128 SPBio_000184 COC1C[C@H]2N3CC(O)C2(C=C1)c4cc5OCOc5cc4C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J07 compound treatment 18960.0 -97800.0 -0.83 16800.0 -81700.0 -0.68 -1.0665 -0.9946 3177381 SPBio_000185 Oc1ccc(cc1)C(=O)/C=C/c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J08 compound treatment 243000.0 126000.0 1.07 222280.0 124000.0 1.02 1.4844 0.9997 2060036 SPBio_000186 CC1=CCc2c(O)c3c(=O)cc(C)oc3cc2OC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J09 compound treatment 246200.0 129000.0 1.1 219160.0 121000.0 1.0 1.4854 0.9988 2060263 SPBio_000187 COc1ccc(C(=O)c2ccc(O)cc2)c(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J10 compound treatment 262400.0 146000.0 1.24 258280.0 160000.0 1.32 1.8117 0.9995 2060187 SPBio_000188 COc1cccc(/C=C/C(=O)O)c1C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J11 compound treatment 278960.0 162000.0 1.38 269960.0 171000.0 1.42 1.9798 0.9999 1032994 SPBio_000189 O=C1CC(Oc2ccccc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J12 compound treatment 236200.0 119000.0 1.02 220760.0 122000.0 1.01 1.4345 1.0 2060117 SPBio_000190 Cc1ccc2c(CC[C@H]3CC(=O)CC[C@@]32C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J13 compound treatment 299160.0 182000.0 1.55 275160.0 177000.0 1.46 2.1318 0.9995 2060208 SPBio_000191 COC(=O)C[C@H]1C(C)(C)[C@@H](O)[C@@H]2CC3=C4CC(O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J14 compound treatment 301120.0 184000.0 1.57 240520.0 142000.0 1.18 1.941 0.9898 2060158 SPBio_000192 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](OC(=O)C)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J15 compound treatment 272520.0 156000.0 1.33 207520.0 109000.0 0.9 1.5757 0.9824 3058620 SPBio_000193 O[C@@H](C(=O)O)[C@@](O)(Cc1ccc(O)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J16 compound treatment 283440.0 167000.0 1.42 241760.0 143000.0 1.19 1.8418 0.996 2060153 SPBio_000194 COc1cccc2c1CCC3=CC(=O)CC[C@@]32C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J17 compound treatment 161680.0 44900.0 0.38 94560.0 -3910.0 -0.03 0.2476 0.645 2060238 SPBio_000195 Cc1cc(O)cc(O)c1C(=O)Oc2cc(C)c(C(=O)Oc3cc(C)c(C(=O)O)c(O)c3)c(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J18 compound treatment 21080.0 -95700.0 -0.81 17920.0 -80600.0 -0.67 -1.0472 -0.995 3173991 SPBio_000196 C[C@@]12CCC3C(CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)C[C@H](O)[C@@H]1C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J19 compound treatment 40360.0 -76400.0 -0.65 25200.0 -73300.0 -0.61 -0.8885 -0.9994 2060216 SPBio_000197 COc1cc2OC[C@H]3Oc4c(ccc5oc(cc45)C(C)C)C(=O)[C@H]3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J20 compound treatment 21160.0 -95600.0 -0.81 13720.0 -84800.0 -0.7 -1.0713 -0.9972 2060214 SPBio_000198 COc1c(ccc2OC(C)(C)C=Cc12)c3coc4cc5OC(C)(C)C(O)Cc5cc4c3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J21 compound treatment 195160.0 78400.0 0.67 214040.0 116000.0 0.96 1.1481 0.9846 2060242 SPBio_000199 COc1ccc(cc1)c2cc(=O)c3c(O)c(OC)c(O[C@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J22 compound treatment 125800.0 9050.0 0.08 120640.0 22200.0 0.18 0.1842 0.9259 3077173 SPBio_000200 CCOc1ccc(cc1)C(=O)c2ccc(OC)c(O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J23 mock treatment 122920.0 6170.0 0.05 142680.0 44200.0 0.37 0.2958 0.8005 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 J24 mock treatment 108560.0 -8190.0 -0.07 49800.0 -48700.0 -0.4 -0.334 -0.8173 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K01 mock treatment 189400.0 72700.0 0.62 35600.0 -62900.0 -0.52 0.0696 0.0862 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K02 mock treatment 151000.0 34300.0 0.29 107080.0 8610.0 0.07 0.2566 0.8546 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K03 compound treatment 123240.0 6490.0 0.06 139520.0 41000.0 0.34 0.2792 0.8116 1403 SPBio_000201 COC(=O)C1=CCCN(C)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K04 compound treatment 210560.0 93800.0 0.8 215760.0 117000.0 0.97 1.2509 0.9953 1167 SPBio_000202 NCCCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K05 compound treatment 238120.0 121000.0 1.03 195160.0 96700.0 0.8 1.2963 0.992 1013706 SPBio_000203 O=c1c2ccccc2oc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K06 compound treatment 257720.0 141000.0 1.2 209200.0 111000.0 0.92 1.4965 0.9911 834 SPBio_000204 CC(C[N+](C)(C)C)OC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K07 compound treatment 157280.0 40500.0 0.35 96760.0 -1710.0 -0.01 0.234 0.6775 592 SPBio_000205 Oc1ccc(cc1)c2coc3cc(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K08 compound treatment 232840.0 116000.0 0.99 154120.0 55600.0 0.46 1.0245 0.9395 1059 SPBio_000206 CN(C)CC/C=C\1/c2ccccc2COc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K09 compound treatment 40000.0 -76700.0 -0.65 30920.0 -67600.0 -0.56 -0.8572 -0.997 2069329 SPBio_000207 COc1cc(O)c2c(=O)cc(oc2c1)c3ccc(OC)c(c3)c4c(O)cc(O)c5c(=O)cc(oc45)c6ccc(O)cc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K10 compound treatment 20320.0 -96400.0 -0.82 15520.0 -83000.0 -0.69 -1.0658 -0.996 1373 SPBio_000208 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K11 compound treatment 257240.0 140000.0 1.2 229800.0 131000.0 1.09 1.6141 0.9988 2069249 SPBio_000209 COc1ccc(cc1)c2coc3c(O)c(OC)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K12 compound treatment 192120.0 75400.0 0.64 145720.0 47200.0 0.39 0.7302 0.9717 1360 SPBio_000210 Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K13 compound treatment 216480.0 99700.0 0.85 263640.0 165000.0 1.37 1.5666 0.9738 1250 SPBio_000211 COc1cc(C)c2c(=O)cc(oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K14 compound treatment 305600.0 189000.0 1.61 233760.0 135000.0 1.12 1.9284 0.9843 1396 SPBio_000212 Cc1cc(O)cc(C)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K15 compound treatment 80640.0 -36100.0 -0.31 70720.0 -27800.0 -0.23 -0.3797 -0.9897 1672652 SPBio_000213 COc1ccc(cc1)c2cc(=O)c3ccc(OC)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K16 compound treatment 264440.0 148000.0 1.26 143680.0 45200.0 0.37 1.1536 0.8793 2069266 SPBio_000214 CNC(C)[C@H](O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K17 compound treatment 300920.0 184000.0 1.57 116040.0 17600.0 0.15 1.2116 0.7693 2069226 SPBio_000215 COc1ccc2-c3oc4cc(OC)ccc4c3COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K18 compound treatment 242440.0 126000.0 1.07 184720.0 86200.0 0.71 1.2613 0.9806 1445 SPBio_000216 C/C=C(/C)\C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@@H]4[C@@]2(C[C@@]5(O)[C@@H]6CN7C[C@@H](C)CC[C@H]7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]45O)O[C@@]31O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K19 compound treatment 308080.0 191000.0 1.63 156600.0 58100.0 0.48 1.492 0.8784 353 SPBio_000217 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K20 compound treatment 38080.0 -78700.0 -0.67 15160.0 -83300.0 -0.69 -0.961 -0.9999 1476 SPBio_000218 CNCCCC1(CCC2c3ccccc31)c4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K21 compound treatment 164480.0 47700.0 0.41 152640.0 54200.0 0.45 0.6042 0.9988 1116 SPBio_000219 S=c1[nH]cnc2nc[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K22 compound treatment 118760.0 2010.0 0.02 93840.0 -4630.0 -0.04 -0.015 -0.3566 1095 SPBio_000220 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K23 mock treatment 103040.0 -13700.0 -0.12 119200.0 20700.0 0.17 0.0387 0.1868 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 K24 mock treatment 178520.0 61800.0 0.53 45520.0 -53000.0 -0.44 0.0622 0.0908 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L01 mock treatment 174440.0 57700.0 0.49 32800.0 -65700.0 -0.54 -0.0368 -0.0503 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L02 mock treatment 140040.0 23300.0 0.2 80080.0 -18400.0 -0.15 0.0327 0.1306 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L03 compound treatment 132280.0 15500.0 0.13 97640.0 -833.0 -0.01 0.0887 0.6694 1090422 SPBio_000221 Cc1cc(O)cc(O)c1C(=O)Oc2cc(C)c(C(=O)O)c(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L04 compound treatment 153360.0 36600.0 0.31 106640.0 8170.0 0.07 0.2682 0.8408 3077174 SPBio_000222 CC(=O)Oc1ccc(cc1)c2cc(=O)c3c(OC(=O)C)cc(OC(=O)C)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L05 compound treatment 229440.0 113000.0 0.96 137280.0 38800.0 0.32 0.9055 0.8949 2060043 SPBio_000223 COc1cc(OC)c(Cl)c2OC3(C(C)CC(=O)C=C3O)C(=O)c21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L06 compound treatment 24360.0 -92400.0 -0.79 18080.0 -80400.0 -0.67 -1.0265 -0.9965 3077175 SPBio_000224 COc1ccc2C(=O)/C(=C\c3ccc(O)c(O)c3)/COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L07 compound treatment 195760.0 79000.0 0.67 183120.0 84600.0 0.7 0.9709 0.9998 812 SPBio_000225 COC1=CC(=O)C[C@@H](C)[C@@]21Oc3c(C2=O)c(OC)cc(OC)c3Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L08 compound treatment 280600.0 164000.0 1.4 187880.0 89400.0 0.74 1.5095 0.956 3054572 SPBio_000226 CC(=O)O[C@@H]1CC[C@@]2(C)C(CC[C@]3(C)C2CC=C4C5CC(C)(C)CC[C@@]5(CC[C@]43C)C(=O)O)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L09 compound treatment 243960.0 127000.0 1.08 138720.0 40200.0 0.33 1.0013 0.8837 1051460 SPBio_000227 COc1cc(C(=O)O)c2Oc3c(C=O)c(O)cc(C)c3C(=O)Oc2c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L10 compound treatment 72640.0 -44100.0 -0.38 58160.0 -40300.0 -0.33 -0.5014 -0.9982 2060234 SPBio_000228 COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L11 compound treatment 288560.0 172000.0 1.46 278360.0 180000.0 1.49 2.0867 1.0 2060040 SPBio_000229 CCOC(=O)C1(O)Oc2cc(OC)cc(OC)c2C(=O)C1c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L12 compound treatment 21640.0 -95100.0 -0.81 14640.0 -83800.0 -0.69 -1.063 -0.997 2069327 SPBio_000230 COC/1=CC(=O)C(=C\C1=C/C=C/c2ccccc2)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L13 compound treatment 33640.0 -83100.0 -0.71 17200.0 -81300.0 -0.67 -0.9758 -0.9997 2069243 SPBio_000231 O/C(=C\C(=O)c1ccccc1O)/c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L14 compound treatment 212320.0 95600.0 0.81 148240.0 49800.0 0.41 0.8665 0.9502 3173492 SPBio_000232 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(O)ccc3-c2c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L15 compound treatment 277600.0 161000.0 1.37 132920.0 34400.0 0.28 1.1699 0.8363 2060463 SPBio_000233 COc1ccc(cc1)c2coc3c(OC)c(OC)cc(O)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L16 compound treatment 22400.0 -94300.0 -0.8 10480.0 -88000.0 -0.73 -1.0827 -0.9988 2081025 SPBio_000234 C[C@H]1CCC[C@]2(C)C[C@H]3OC(=O)C(=C)[C@H]3C=C12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L17 compound treatment 274920.0 158000.0 1.35 120400.0 21900.0 0.18 1.0806 0.7952 3172979 SPBio_000235 C[C@H]1C2C(CC3C4CC=C5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L18 compound treatment 185640.0 68900.0 0.59 108640.0 10200.0 0.08 0.4743 0.8003 3058525 SPBio_000236 COc1cc2OC[C@H]3Oc4c5C=CC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L19 compound treatment 268640.0 152000.0 1.29 175480.0 77000.0 0.64 1.365 0.9468 923 SPBio_000237 NC(=O)NC1NC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L20 compound treatment 203080.0 86300.0 0.74 124280.0 25800.0 0.21 0.6707 0.8763 3077176 SPBio_000238 COc1ccc(c(O)c1O)c2coc3cc(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L21 compound treatment 217560.0 101000.0 0.86 118240.0 19800.0 0.16 0.7226 0.8269 3198310 SPBio_000239 COc1ccc([C@H]2COc3c(OC)c(O)ccc3C2)c(OC)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L22 compound treatment 52680.0 -64100.0 -0.55 26760.0 -71700.0 -0.59 -0.8052 -0.9991 3077177 SPBio_000240 CC(=O)OCC(O)CC(=O)CCCCCCCCCCCC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L23 mock treatment 168680.0 51900.0 0.44 79280.0 -19200.0 -0.16 0.2004 0.4265 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 L24 mock treatment 174440.0 57700.0 0.49 51440.0 -47000.0 -0.39 0.0722 0.1153 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M01 mock treatment 152000.0 35300.0 0.3 38560.0 -59900.0 -0.5 -0.1382 -0.2385 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M02 mock treatment 171520.0 54800.0 0.47 92480.0 -5990.0 -0.05 0.2947 0.6284 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M03 compound treatment 161600.0 44900.0 0.38 62640.0 -35800.0 -0.3 0.0604 0.125 3177464 SPBio_000241 NCCCC(N)CC(=O)NCC1NC(=O)C(CO)NC(=O)C(N)CNC(=O)C(NC(=O)/C(=C\NC(=O)N)/NC1=O)C2CCNC(=N)N2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M04 compound treatment 146160.0 29400.0 0.25 75840.0 -22600.0 -0.19 0.0447 0.1429 984 SPBio_000242 C[C@H]1CC2C3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)C2[C@@]4(C)CCC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M05 compound treatment 230200.0 113000.0 0.97 122840.0 24400.0 0.2 0.8256 0.8366 1149 SPBio_000243 CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M06 compound treatment 15000.0 -102000.0 -0.87 8160.0 -90300.0 -0.75 -1.1409 -0.9973 1011303 SPBio_000244 CN1CCc2cccc-3c2C1Cc4ccc(O)c(O)c43 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M07 compound treatment 104040.0 -12700.0 -0.11 47040.0 -51400.0 -0.43 -0.3774 -0.8595 3173471 SPBio_000245 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M08 compound treatment 264080.0 147000.0 1.25 112760.0 14300.0 0.12 0.9706 0.7703 980 SPBio_000246 C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)[C@@]3(O)C(=C2C(=O)c4c(O)cccc14)O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M09 compound treatment 270680.0 154000.0 1.31 135880.0 37400.0 0.31 1.1456 0.8507 430 SPBio_000247 NC(=O)NO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M10 compound treatment 179720.0 63000.0 0.54 104920.0 6450.0 0.05 0.4169 0.7736 1481 SPBio_000248 Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc4ccccc14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M11 compound treatment 249320.0 133000.0 1.13 132760.0 34300.0 0.28 0.9987 0.8581 1295 SPBio_000249 OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M12 compound treatment 270320.0 154000.0 1.31 217720.0 119000.0 0.99 1.6222 0.9903 3045196 SPBio_000250 CC1(C)S[C@@H]2[C@H](NC(=O)[C@@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M13 compound treatment 34720.0 -82000.0 -0.7 13520.0 -85000.0 -0.7 -0.9908 -1.0 892 SPBio_000251 C[n+]1c2cc(N)ccc2cc3ccc(N)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M14 compound treatment 22560.0 -94200.0 -0.8 10920.0 -87600.0 -0.72 -1.0792 -0.9987 1309 SPBio_000252 Cc1cc(C2CCCCC2)n(O)c(=O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M15 compound treatment 286520.0 170000.0 1.45 86560.0 -11900.0 -0.1 0.9524 0.6574 1437 SPBio_000253 CS(=O)(=O)OCCCCOS(=O)(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M16 compound treatment 250120.0 133000.0 1.14 60720.0 -37800.0 -0.31 0.5821 0.4943 1110 SPBio_000254 C[C@H]1CC2C3CC[C@](OC(=O)C)(C(=O)C)[C@@]3(C)CCC2[C@@]4(C)CCC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M17 compound treatment 122360.0 5610.0 0.05 77160.0 -21300.0 -0.18 -0.0909 -0.4974 1198 SPBio_000255 Cn1cnc([N+](=O)[O-])c1Sc2[nH]cnc3ncnc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M18 compound treatment 21600.0 -95100.0 -0.81 8640.0 -89800.0 -0.74 -1.0983 -0.9991 1138 SPBio_000256 CC/C(=C(/CC)\c1ccc(O)cc1)/c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M19 compound treatment 274400.0 158000.0 1.34 122360.0 23900.0 0.2 1.0889 0.8026 3174477 SPBio_000257 CN[C@H](CC(C)C)C(=O)NC1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6CC(=O)C(NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@@H](NC6=O)C(=O)O)c3O[C@@H]9OC(CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M20 compound treatment 149720.0 33000.0 0.28 54080.0 -44400.0 -0.37 -0.0612 -0.1323 982 SPBio_000258 CC(=O)Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M21 compound treatment 32360.0 -84400.0 -0.72 25800.0 -72700.0 -0.6 -0.9332 -0.9961 707 SPBio_000259 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CCC6C5CC[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M22 compound treatment 11320.0 -105000.0 -0.9 5240.0 -93200.0 -0.77 -1.1801 -0.9971 2114344 SPBio_000260 CC1=C(O)C(=O)C=C2C1=CC=C3[C@@]2(C)CC[C@@]4(C)[C@@H]5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M23 mock treatment 161200.0 44500.0 0.38 97520.0 -953.0 -0.01 0.2621 0.6922 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 M24 mock treatment 156600.0 39900.0 0.34 39760.0 -58700.0 -0.49 -0.1035 -0.1747 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N01 mock treatment 141120.0 24400.0 0.21 58240.0 -40200.0 -0.33 -0.0886 -0.2259 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N02 mock treatment 209080.0 92300.0 0.79 93720.0 -4750.0 -0.04 0.5281 0.6709 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N03 compound treatment 190120.0 73400.0 0.62 74680.0 -23800.0 -0.2 0.3026 0.4619 970 SPBio_000261 CC1(C)O[C@]2(C)CC[C@H]1CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N04 compound treatment 115720.0 -1030.0 -0.01 42520.0 -56000.0 -0.46 -0.3335 -0.7203 2060424 SPBio_000262 C[C@@]12CC[C@@H](O)C[C@H]2CCc3ccccc31 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N05 compound treatment 228440.0 112000.0 0.95 73400.0 -25100.0 -0.21 0.5258 0.5402 893 SPBio_000263 NCC(O)c1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N06 compound treatment 155480.0 38700.0 0.33 100840.0 2370.0 0.02 0.247 0.7478 2060300 SPBio_000264 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O)c(c4cc(ccc4OC)c5cc(=O)c6c(O)cc(O)cc6o5)c3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N07 compound treatment 261000.0 144000.0 1.23 89400.0 -9070.0 -0.08 0.8154 0.6627 2060025 SPBio_000265 CC(=O)O[C@H]1C[C@@]2(C)[C@@H](OC(=O)[C@H]3O[C@]32[C@]4(C)[C@@H](CC5C(C)(C)[C@@H](C[C@H](OC(=O)C)[C@]5(C)C14)OC(=O)C)OC(=O)C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N08 compound treatment 298080.0 181000.0 1.54 79520.0 -19000.0 -0.16 0.9809 0.632 1010471 SPBio_000266 O=c1ccc2ccccc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N09 compound treatment 263080.0 146000.0 1.25 101360.0 2890.0 0.02 0.8979 0.7205 3173997 SPBio_000267 COC(=O)CC1C(C)(C)C(=O)C=CC1(C)C2CC[C@@]3(C)[C@@H](OC(=O)C4OC43C2=C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N10 compound treatment 18480.0 -98300.0 -0.84 8120.0 -90400.0 -0.75 -1.1201 -0.9984 2060107 SPBio_000268 COC1=C(OC)C(=O)C(=CC1=O)[C@H](C=C)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N11 compound treatment 21480.0 -95300.0 -0.81 10400.0 -88100.0 -0.73 -1.0887 -0.9986 3054122 SPBio_000269 CC(=O)O[C@@H]1C[C@@]2(C)[C@@H](C[C@H]3O[C@]32[C@@]4(C)C1[C@@]5(C)C=CC(=O)C(C)(C)C5=C(O)C4=O)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N12 compound treatment 306440.0 190000.0 1.62 189240.0 90800.0 0.75 1.673 0.9393 2060113 SPBio_000270 Cc1cc(O)cc(O)c1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N13 compound treatment 285360.0 169000.0 1.44 228440.0 130000.0 1.08 1.7754 0.9899 2060028 SPBio_000271 COC(=O)C[C@H]1C2(C)CC3(OC4(C)O[C@@]56[C@H](OC(=O)C)[C@@]3(O)C2OC(=O)C(C)C)[C@]1(C)[C@@]6(O4)[C@H](OC(=O)C)C(OC(=O)C)[C@@]7(C)[C@@H](OC(=O)/C(=C(\O)/C(C)C)/C57)c8ccoc8 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N14 compound treatment 253280.0 137000.0 1.16 170680.0 72200.0 0.6 1.2444 0.9521 2060136 SPBio_000272 CC(=C)c1cc2cc(C(=O)C)c(O)cc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N15 compound treatment 256200.0 139000.0 1.19 77360.0 -21100.0 -0.17 0.7161 0.5967 2060030 SPBio_000273 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3C(CC[C@@]4(C)[C@@H](OC(=O)C=C34)c5ccoc5)[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N16 compound treatment 213960.0 97200.0 0.83 21200.0 -77300.0 -0.64 0.1333 0.1274 1049466 SPBio_000274 COc1cc(C)c2C(=O)Oc3c(C)c(O)c4C(=O)OC(O)c4c3Oc2c1C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N17 compound treatment 20480.0 -96300.0 -0.82 5520.0 -93000.0 -0.77 -1.1233 -0.9995 2060031 SPBio_000275 C[C@]12CCC3[C@@]4(C)C=CC(=O)C(C)(C)C4=C(O)C(=O)[C@@]3(C)[C@]25O[C@@H]5C[C@H]1c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N18 compound treatment 252680.0 136000.0 1.16 58680.0 -39800.0 -0.33 0.5856 0.4867 1086162 SPBio_000276 COc1c2ccoc2c(OC)c3oc(=O)ccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N19 compound treatment 150400.0 33700.0 0.29 74360.0 -24100.0 -0.2 0.0616 0.1763 2060035 SPBio_000277 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)[C@@]2(C)C=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N20 compound treatment 122040.0 5290.0 0.05 53960.0 -44500.0 -0.37 -0.2285 -0.6159 3077178 SPBio_000278 CC1CCC2(C)C(CCC=C2C)C1(C)CC/C(=C/Cn3c[n+](C)c4c(N)ncnc34)/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N21 compound treatment 206680.0 89900.0 0.77 90200.0 -8270.0 -0.07 0.4931 0.6414 2060230 SPBio_000279 CC(=O)O[C@H]1C[C@@H](O)C(C)(C)C2C[C@@H](OC(=O)C)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N22 compound treatment 82680.0 -34100.0 -0.29 32200.0 -66300.0 -0.55 -0.5928 -0.9557 2069254 SPBio_000280 CCCCCc1c(C(=O)O)c(O)cc2OC(=O)c3c(cc(OC)cc3Oc12)C(=O)CCCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N23 mock treatment 196800.0 80100.0 0.68 63960.0 -34500.0 -0.29 0.2801 0.379 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 N24 mock treatment 158800.0 42100.0 0.36 74520.0 -24000.0 -0.2 0.1131 0.2763 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O01 mock treatment 80120.0 -36600.0 -0.31 53520.0 -45000.0 -0.37 -0.4835 -0.9962 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O02 mock treatment 183280.0 66500.0 0.57 69880.0 -28600.0 -0.24 0.2333 0.3801 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O03 compound treatment 169400.0 52700.0 0.45 60360.0 -38100.0 -0.32 0.0941 0.1716 3173595 SPBio_000281 C[C@H]1OC(OC/2CC3O[C@@](O)(CC(O)C3C(=O)O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)C(C)[C@H](O)[C@@H](C)/C=C/C=C/CC\C=C\C=C\C=C\C=C2)[C@@H](O)[C@@H](N)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O04 compound treatment 225920.0 109000.0 0.93 71360.0 -27100.0 -0.22 0.4987 0.5215 1002775 SPBio_000282 Cc1cccc(C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O05 compound treatment 22840.0 -93900.0 -0.8 12320.0 -86200.0 -0.71 -1.0693 -0.9984 1000036 SPBio_000283 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3C2C[C@@H]1CC4NCCc5cc(OC)c(OC)cc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O06 compound treatment 246440.0 130000.0 1.1 75120.0 -23400.0 -0.19 0.6442 0.5747 3058740 SPBio_000284 CC(=O)O[C@@H]1CC[C@@]2(C)[C@@H](CCC3C4CCC(=O)[C@@]4(C)CCC32)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O07 compound treatment 183960.0 67200.0 0.57 49120.0 -49400.0 -0.41 0.116 0.165 1383 SPBio_000285 CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2OC3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O08 compound treatment 17520.0 -99200.0 -0.84 5120.0 -93400.0 -0.77 -1.1435 -0.999 943 SPBio_000286 CCCCC1C(=O)N(N(C1=O)c2ccc(O)cc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O09 compound treatment 172560.0 55800.0 0.48 20320.0 -78200.0 -0.65 -0.1211 -0.151 1260 SPBio_000287 N[C@@H](Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O10 compound treatment 289360.0 173000.0 1.47 66600.0 -31900.0 -0.26 0.8528 0.5711 1282 SPBio_000288 NS(=O)(=O)c1cc2c(N=CNS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O11 compound treatment 183480.0 66700.0 0.57 92840.0 -5630.0 -0.05 0.3688 0.6469 1352 SPBio_000289 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O12 compound treatment 328160.0 211000.0 1.8 166920.0 68400.0 0.57 1.6732 0.8867 1020 SPBio_000290 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O13 compound treatment 299400.0 183000.0 1.56 191000.0 92500.0 0.77 1.6409 0.9467 720 SPBio_000291 Fc1c[nH]c(=O)[nH]c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O14 compound treatment 323960.0 207000.0 1.76 119720.0 21200.0 0.18 1.3718 0.7737 2069230 SPBio_000292 CN(C)CC[C@H](c1ccc(Cl)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O15 compound treatment 301840.0 185000.0 1.58 64920.0 -33600.0 -0.28 0.9181 0.5737 1154 SPBio_000293 O=C1CC2OCC=C3CN4CC[C@]56C4C[C@@H]3[C@@H]2C6N1c7ccccc75 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O16 compound treatment 279120.0 162000.0 1.38 52240.0 -46200.0 -0.38 0.7071 0.493 877 SPBio_000294 CC(C)(Oc1ccc(Cl)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O17 compound treatment 338800.0 222000.0 1.89 42280.0 -56200.0 -0.46 1.0082 0.5178 3177389 SPBio_000295 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O18 compound treatment 257800.0 141000.0 1.2 33200.0 -65300.0 -0.54 0.4674 0.355 907 SPBio_000296 OC(=O)c1cc(O)c2cccc(O)c2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O19 compound treatment 15920.0 -101000.0 -0.86 4960.0 -93500.0 -0.77 -1.154 -0.9987 1288 SPBio_000297 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O)[C@H](C)O2)N(C)C)c3c(O)c4C(=O)c5c(O)cccc5C(=O)c4cc3[C@H]1C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O20 compound treatment 116760.0 14.4 0.0 52680.0 -45800.0 -0.38 -0.2678 -0.7069 1006 SPBio_000298 Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@@H]2O)c(=O)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O21 compound treatment 223360.0 107000.0 0.91 50720.0 -47800.0 -0.4 0.3625 0.3662 3174227 SPBio_000299 CC[C@@H]1[C@@H](O)N2[C@H]3C[C@@]45C(O)C3[C@@H]1CC2[C@@H]5N(C)c6ccccc64 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O22 compound treatment 210760.0 94000.0 0.8 110000.0 11500.0 0.1 0.6334 0.7858 3077148 SPBio_000300 CCCCC(=O)Oc1ccccc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O23 mock treatment 202880.0 86100.0 0.73 67440.0 -31000.0 -0.26 0.337 0.4338 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 O24 mock treatment 122680.0 5930.0 0.05 45960.0 -52500.0 -0.43 -0.2715 -0.6207 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P01 mock treatment 47120.0 -69600.0 -0.59 69680.0 -28800.0 -0.24 -0.5876 -0.9198 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P02 mock treatment 91840.0 -24900.0 -0.21 71000.0 -27500.0 -0.23 -0.3107 -0.9994 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P03 compound treatment 87440.0 -29300.0 -0.25 43040.0 -55400.0 -0.46 -0.5007 -0.9591 2060147 SPBio_000301 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P04 compound treatment 166720.0 50000.0 0.43 43000.0 -55500.0 -0.46 -0.0236 -0.0378 2060138 SPBio_000302 C[C@]1([C@H]2[C@H](C(=O)O)[C@]3(CC(=C)[C@@]4(O)C3)[C@@H](CC4)[C@]52OC1=O)[C@@H](O)C=C5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P05 compound treatment 195160.0 78400.0 0.67 41440.0 -57000.0 -0.47 0.1385 0.1694 2060038 SPBio_000303 COC(=O)C[C@H]1C(C)(C)C(=O)C=C[C@]1(C)C2CC[C@@]3(C)[C@@H](OC(=O)C=C3C2=C)c4ccoc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P06 compound treatment 242920.0 126000.0 1.07 40320.0 -58200.0 -0.48 0.4195 0.3564 1098 SPBio_000304 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P07 compound treatment 286520.0 170000.0 1.45 31800.0 -66700.0 -0.55 0.6321 0.4086 2060055 SPBio_000305 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P08 compound treatment 258240.0 141000.0 1.2 40520.0 -58000.0 -0.48 0.5129 0.3955 2060140 SPBio_000306 COc1cc2occc2c3oc(=O)ccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P09 compound treatment 105600.0 -11100.0 -0.09 15160.0 -83300.0 -0.69 -0.5545 -0.7969 1609 SPBio_000307 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P10 compound treatment 14480.0 -102000.0 -0.87 4640.0 -93800.0 -0.78 -1.1646 -0.9984 2060142 SPBio_000308 CC(=O)OC1C/C(=C/CC/C(=C/CC[C@](C)(O)C2CC1C(=C)C(=O)O2)/C)/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P11 compound treatment 265240.0 148000.0 1.26 72480.0 -26000.0 -0.22 0.742 0.5785 2060059 SPBio_000309 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](C[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P12 compound treatment 307080.0 190000.0 1.62 138480.0 40000.0 0.33 1.3799 0.8343 3059434 SPBio_000310 C[C@]12CC[C@@H]3[C@H](CC3(C)C)C(=O)CC[C@H]2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P13 compound treatment 297320.0 181000.0 1.54 101840.0 3370.0 0.03 1.1068 0.7198 2060060 SPBio_000311 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)[C@@]2(C)C=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P14 compound treatment 296200.0 179000.0 1.53 65000.0 -33500.0 -0.28 0.8846 0.5697 2060170 SPBio_000312 CC(=O)OC1CCC2(O)CC1(C)CCC3C2CC3(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P15 compound treatment 314280.0 198000.0 1.68 65440.0 -33000.0 -0.27 0.996 0.5846 2060062 SPBio_000313 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P16 compound treatment 227440.0 111000.0 0.94 24960.0 -73500.0 -0.61 0.2364 0.2108 2060421 SPBio_000314 C[C@](O)(CCC1C(=C)C[C@H](O)C2C(C)(C)CCCC12C)C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P17 compound treatment 291000.0 174000.0 1.48 35960.0 -62500.0 -0.52 0.6834 0.435 2060063 SPBio_000315 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](C(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P18 compound treatment 144040.0 27300.0 0.23 7320.0 -91200.0 -0.75 -0.3689 -0.4675 3177379 SPBio_000316 CC(=O)O[C@H]1CC(=C)C(CC[C@](C)(O)C=C)C2(C)CCCC(C)(C)C12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P19 compound treatment 248720.0 132000.0 1.12 39280.0 -59200.0 -0.49 0.4483 0.3657 2060066 SPBio_000317 COC(=O)CC1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P20 compound treatment 133360.0 16600.0 0.14 40400.0 -58100.0 -0.48 -0.2397 -0.4786 2060175 SPBio_000318 C[C@](O)(CCC1C(=C)CCC2[C@@](C)(CO)CCC[C@]12C)C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P21 compound treatment 151240.0 34500.0 0.29 56440.0 -42000.0 -0.35 -0.0382 -0.0839 3173867 SPBio_000319 COC(=O)C[C@H]1C(C)(C)C(=O)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P22 compound treatment 64000.0 -52700.0 -0.45 49400.0 -49100.0 -0.41 -0.6046 -0.9987 2060166 SPBio_000320 CC1(C)CC2C1CCC(=C)/C(=N\O)/CCC2=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P23 mock treatment 84160.0 -32600.0 -0.28 83920.0 -14600.0 -0.12 -0.2813 -0.9301 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2158 P24 mock treatment 44880.0 -71900.0 -0.61 49120.0 -49400.0 -0.41 -0.7214 -0.9807 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A01 mock treatment 66360.0 -32200.0 -0.27 129800.0 -6780.0 -0.06 -0.2335 -0.8345 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A02 mock treatment 125920.0 27400.0 0.23 127640.0 -8940.0 -0.07 0.1124 0.46 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A03 compound treatment 84240.0 -14300.0 -0.12 74640.0 -61900.0 -0.51 -0.4485 -0.8516 1030891 SPBio_000321 Cc1cc(=O)oc2c(O)c(O)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A04 compound treatment 206280.0 108000.0 0.92 118360.0 -18200.0 -0.15 0.5419 0.5831 1109169 SPBio_000322 COc1ccc2c(=O)c(coc2c1)c3cc4OCOc4cc3OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A05 compound treatment 235280.0 137000.0 1.16 96080.0 -40500.0 -0.34 0.5862 0.4839 1552436 SPBio_000323 COc1ccc(cc1)c2cc(=O)c3cc(OC)ccc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A06 compound treatment 274320.0 176000.0 1.5 76280.0 -60300.0 -0.5 0.7054 0.4472 2060405 SPBio_000324 CC1(C)[C@H](CC(=O)O)[C@@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]3(O)C[C@@H](C1=O)C2=O)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A07 compound treatment 244120.0 146000.0 1.24 44880.0 -91700.0 -0.76 0.3399 0.2339 2060323 SPBio_000325 COc1ccccc1c2cc(=O)c3c(OC)cccc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A08 compound treatment 268800.0 170000.0 1.45 60560.0 -76000.0 -0.63 0.5802 0.3672 2060179 SPBio_000326 COc1cccc2c1CCC3CC(=O)CC[C@@]32C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A09 compound treatment 254440.0 156000.0 1.33 79200.0 -57400.0 -0.47 0.6028 0.4277 1499608 SPBio_000327 COc1ccc2c(=O)cc(oc2c1)c3ccccc3OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A10 compound treatment 272400.0 174000.0 1.48 78960.0 -57600.0 -0.48 0.7095 0.4563 3077346 SPBio_000328 COC(=O)c1c(C)cc(OC)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A11 compound treatment 260000.0 161000.0 1.37 99520.0 -37100.0 -0.31 0.7552 0.5362 777 SPBio_000329 Oc1ccc(cc1)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A12 compound treatment 268440.0 170000.0 1.45 181840.0 45300.0 0.37 1.2875 0.8617 1009851 SPBio_000330 O=C1c2ccccc2C(=O)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A13 compound treatment 292200.0 194000.0 1.65 156760.0 20200.0 0.17 1.2839 0.7747 2060418 SPBio_000331 COc1ccccc1c2cc(=O)c3cccc(OC)c3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A14 compound treatment 271240.0 173000.0 1.47 116800.0 -19800.0 -0.16 0.9239 0.6245 2060380 SPBio_000332 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)C3(F)[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A15 compound treatment 239560.0 141000.0 1.2 81320.0 -55300.0 -0.46 0.5256 0.4092 2060322 SPBio_000333 COc1ccc2c(=O)c(OC)c(oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A16 compound treatment 263000.0 164000.0 1.4 78200.0 -58400.0 -0.48 0.6485 0.4379 2579 SPBio_000334 OCCSCCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A17 compound treatment 255200.0 157000.0 1.33 79600.0 -57000.0 -0.47 0.6097 0.431 3173852 SPBio_000335 COc1ccc(CCC(=O)c2c(O)cc(O[C@@H]3O[C@H](CO)C(O)[C@H](O)C3O[C@@H]4O[C@@H](C)[C@H](O)[C@@H](O)[C@H]4O)cc2O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A18 compound treatment 268240.0 170000.0 1.44 71680.0 -64900.0 -0.54 0.6419 0.4165 3173468 SPBio_000336 COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A19 compound treatment 255880.0 157000.0 1.34 130400.0 -6180.0 -0.05 0.911 0.6796 3177315 SPBio_000337 CC1O[C@@H](Oc2c(oc3cc(O)cc(O)c3c2=O)c4ccc(O)c(O)c4)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A20 compound treatment 225080.0 127000.0 1.08 103840.0 -32700.0 -0.27 0.5702 0.5133 1445 SPBio_000338 C/C=C(/C)\C(=O)O[C@H]1CC[C@@]2(C)[C@@H]3CC[C@@H]4[C@@]2(C[C@@]5(O)[C@@H]6CN7C[C@@H](C)CC[C@H]7[C@@](C)(O)[C@@]6(O)[C@@H](O)C[C@@]45O)O[C@@]31O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A21 compound treatment 172920.0 74400.0 0.63 97640.0 -38900.0 -0.32 0.2199 0.3095 976 SPBio_000339 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A22 compound treatment 122360.0 23800.0 0.2 102960.0 -33600.0 -0.28 -0.0534 -0.1551 1112405 SPBio_000340 COc1cc2OCOc2cc1c3cc4cc5ccoc5cc4oc3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A23 mock treatment 103960.0 5400.0 0.05 137040.0 459.0 0.0 0.0352 0.7629 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 A24 mock treatment 52200.0 -46400.0 -0.39 166240.0 29700.0 0.25 -0.1056 -0.2272 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B01 mock treatment 162880.0 64300.0 0.55 149560.0 13000.0 0.11 0.4632 0.8299 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B02 mock treatment 207720.0 109000.0 0.93 120240.0 -16300.0 -0.14 0.5616 0.598 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B03 compound treatment 11720.0 -86800.0 -0.74 7160.0 -129000.0 -1.07 -1.2799 -0.9837 1011006 SPBio_000341 O=C1C=CC(=O)c2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B04 compound treatment 237520.0 139000.0 1.18 80760.0 -55800.0 -0.46 0.5101 0.4016 3172845 SPBio_000342 CCC(C)C(=O)O[C@H]1[C@H](O)C2C(CN3CC(C)CCC3[C@@]2(C)O)C4C[C@]5(O[C@@]6(O)C7C(OC(=O)C)[C@@H](OC(=O)C)C5[C@@]41O)[C@@]7(C)CCC6OC(=O)C(C)(O)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B05 compound treatment 258840.0 160000.0 1.36 110080.0 -26500.0 -0.22 0.8099 0.586 1000322 SPBio_000343 CCOC(=O)[C@H](CCc1ccccc1)N[C@H]2CCc3ccccc3N(CC(=O)O)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B06 compound treatment 228560.0 130000.0 1.11 83320.0 -53300.0 -0.44 0.4711 0.3954 2060143 SPBio_000344 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B07 compound treatment 254240.0 156000.0 1.33 73280.0 -63300.0 -0.52 0.567 0.3978 1001496 SPBio_000345 NC(=O)N1c2ccccc2CC(=O)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B08 compound treatment 274400.0 176000.0 1.5 57800.0 -78800.0 -0.65 0.5978 0.3661 1046 SPBio_000346 CC1C2C(CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC(=O)[C@]23C)OC61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B09 compound treatment 266880.0 168000.0 1.43 54840.0 -81700.0 -0.68 0.5352 0.3377 3198312 SPBio_000347 C[C@@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C2CC[C@]51CCC(=O)O5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B10 compound treatment 257440.0 159000.0 1.35 76360.0 -60200.0 -0.5 0.6043 0.4192 2060339 SPBio_000348 COc1cc2N3C4[C@H]5[C@H]6C[C@@H]7N(CC[C@@]74c2cc1OC)CC6=CCOC5CC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B11 compound treatment 33760.0 -64800.0 -0.55 12600.0 -124000.0 -1.03 -1.1154 -0.9577 2069295 SPBio_000349 CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)c5ccccc5c6nnn[nH]6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B12 compound treatment 263640.0 165000.0 1.41 195240.0 58700.0 0.49 1.337 0.8992 3059432 SPBio_000350 CC(C)CCCC(C)[C@H]1CCC2C3C(CC[C@]12C)[C@@]4(C)CC[C@H](O)CC4=CC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B13 compound treatment 235920.0 137000.0 1.17 163000.0 26400.0 0.22 0.9815 0.825 3480246 SPBio_000351 CCOC(=O)C1=C(COCCN)NC(=C(C1c2ccccc2Cl)C(=O)OC)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B14 compound treatment 252840.0 154000.0 1.31 108600.0 -28000.0 -0.23 0.7652 0.5737 2060325 SPBio_000352 COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(c34)-c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B15 compound treatment 296200.0 198000.0 1.68 99040.0 -37500.0 -0.31 0.9703 0.567 1001366 SPBio_000353 COc1c(N2CCNC(C)C2)c(F)cc3c(=O)c(cn(C4CC4)c13)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B16 compound treatment 271560.0 173000.0 1.47 67560.0 -69000.0 -0.57 0.6378 0.4037 2060251 SPBio_000354 NCC(N)C(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B17 compound treatment 271680.0 173000.0 1.47 60600.0 -76000.0 -0.63 0.5978 0.3731 3198313 SPBio_000355 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)C5[C@H](O)C[C@]43C)[C@@H]2[C@H]1C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B18 compound treatment 173720.0 75200.0 0.64 79640.0 -56900.0 -0.47 0.1194 0.1503 297849 SPBio_000356 COc1ccc2c(c1)[nH]c3c(C)nccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B19 compound treatment 220040.0 121000.0 1.03 83000.0 -53600.0 -0.44 0.4179 0.3714 1001346 SPBio_000357 OC(CC[C@@H]1[C@H](N(C1=O)c2ccc(F)cc2)c3ccc(O)cc3)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B20 compound treatment 247680.0 149000.0 1.27 101280.0 -35300.0 -0.29 0.6913 0.5306 2060051 SPBio_000358 Cc1cc(=O)c2c(O)cc(O)c(C)c2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B21 compound treatment 240360.0 142000.0 1.21 105040.0 -31500.0 -0.26 0.6692 0.5418 1333 SPBio_000359 CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC1=O)C(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B22 compound treatment 225400.0 127000.0 1.08 134000.0 -2580.0 -0.02 0.7485 0.693 956 SPBio_000360 CCn1nc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B23 mock treatment 205920.0 107000.0 0.91 158280.0 21700.0 0.18 0.7733 0.8301 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 B24 mock treatment 66080.0 -32500.0 -0.28 161440.0 24900.0 0.21 -0.0501 -0.1455 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C01 mock treatment 138320.0 39800.0 0.34 108840.0 -27700.0 -0.23 0.0771 0.1885 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C02 mock treatment 193440.0 94900.0 0.81 142960.0 6380.0 0.05 0.6085 0.7517 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C03 compound treatment 163560.0 65000.0 0.55 79920.0 -56700.0 -0.47 0.0599 0.0826 2060213 SPBio_000361 CC1(C)C2CC(=O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)[C@H]6O[C@H]6C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C04 compound treatment 119960.0 21400.0 0.18 76960.0 -59600.0 -0.49 -0.2199 -0.4183 1530 SPBio_000362 COc1ccc2c3CCN=C(C)c3[nH]c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C05 compound treatment 151880.0 53300.0 0.45 70280.0 -66300.0 -0.55 -0.0668 -0.0939 3173352 SPBio_000363 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C06 compound treatment 281360.0 183000.0 1.56 154000.0 17400.0 0.14 1.2024 0.7693 2060407 SPBio_000364 COc1ccc(/C=C/C(=O)O)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C07 compound treatment 247040.0 148000.0 1.26 52560.0 -84000.0 -0.7 0.4024 0.2789 2060232 SPBio_000365 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C08 compound treatment 280000.0 181000.0 1.54 71120.0 -65500.0 -0.54 0.7094 0.4334 2060504 SPBio_000366 Cc1cc(O)c(C)c(O)c1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C09 compound treatment 282200.0 184000.0 1.56 94640.0 -41900.0 -0.35 0.8603 0.5371 2060233 SPBio_000367 COC(=O)C[C@H]1C(C)(C)[C@H](O)[C@@H]2CC3=C4CC(O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C10 compound treatment 227280.0 129000.0 1.1 51440.0 -85100.0 -0.7 0.2769 0.2126 2060400 SPBio_000368 CC(C)c1ccc2c(CCC3[C@](C)(CN)CCC[C@@]32C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C11 compound treatment 237840.0 139000.0 1.19 82680.0 -53900.0 -0.45 0.5232 0.413 2060235 SPBio_000369 CC(=O)O[C@@H]1CC2C(C)(C)C(=O)[C@@H]3O[C@@H]3[C@]2(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C5[C@]14C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C12 compound treatment 251160.0 153000.0 1.3 179400.0 42800.0 0.35 1.1692 0.8682 2060317 SPBio_000370 COc1cc(OC)c2c(OC)c(c3ccc4OCOc4c3)c(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C13 compound treatment 274360.0 176000.0 1.5 237760.0 101000.0 0.84 1.6503 0.9623 2060237 SPBio_000371 CC(=O)O[C@@H]1C[C@H](OC(=O)C)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)C(=O)O)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C14 compound treatment 214840.0 116000.0 0.99 96800.0 -39800.0 -0.33 0.4674 0.448 891 SPBio_000372 CC(=O)OCC(=O)[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C15 compound treatment 210920.0 112000.0 0.96 88440.0 -48100.0 -0.4 0.3949 0.381 2060240 SPBio_000373 CC1=C2C(O)C(=O)OC3CC4C(C)(C)C(=O)C=C[C@]4(C)C(CC1)[C@@]32C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C16 compound treatment 266640.0 168000.0 1.43 74760.0 -61800.0 -0.51 0.6503 0.4279 2060458 SPBio_000374 CC(=O)Oc1cccc(C(=O)O)c1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C17 compound treatment 212760.0 114000.0 0.97 74360.0 -62200.0 -0.51 0.3236 0.2941 2060241 SPBio_000375 CC1(C)C2C[C@@H](O)[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C=C43)c5ccoc5)[C@@]2(C)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C18 compound treatment 107840.0 9280.0 0.08 42920.0 -93700.0 -0.77 -0.492 -0.6317 3172856 SPBio_000376 O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4C(C32)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C19 compound treatment 257480.0 159000.0 1.35 108880.0 -27700.0 -0.23 0.7947 0.5791 2060026 SPBio_000377 COC(=O)C[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3C(CC[C@@]4(C)[C@@H](OC(=O)CC34)c5ccoc5)[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C20 compound treatment 249160.0 151000.0 1.28 112560.0 -24000.0 -0.2 0.7662 0.5905 1010689 SPBio_000378 COc1cc(CC=C)c(OC)c2OCOc21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C21 compound treatment 244480.0 146000.0 1.24 117240.0 -19300.0 -0.16 0.7654 0.611 2060086 SPBio_000379 CCC(C)C(=O)O[C@@H]1C[C@@]2(C)[C@@H](OC(=O)CC32OC4(C)OC53[C@H](OC(=O)C(C)C)[C@@]6(O)[C@@H](OC(=O)C7(C)OC7C)[C@@]8(C)C[C@]6(O)[C@@](C)([C@H]8CC(=O)OC)C15O4)c9ccoc9 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C22 compound treatment 195360.0 96800.0 0.82 86920.0 -49700.0 -0.41 0.2923 0.3174 1000142 SPBio_000380 CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C23 mock treatment 148800.0 50200.0 0.43 126920.0 -9660.0 -0.08 0.246 0.5652 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 C24 mock treatment 30480.0 -68100.0 -0.58 144840.0 8260.0 0.07 -0.3616 -0.6195 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D01 mock treatment 133000.0 34400.0 0.29 71040.0 -65500.0 -0.54 -0.176 -0.2856 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D02 mock treatment 133760.0 35200.0 0.3 82320.0 -54300.0 -0.45 -0.1055 -0.1954 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D03 compound treatment 94120.0 -4440.0 -0.04 55120.0 -81500.0 -0.67 -0.5033 -0.7456 3078456 SPBio_000381 CC(=CCC[C@](C)(O)C1CCC(=CC1)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D04 compound treatment 134760.0 36200.0 0.31 73640.0 -62900.0 -0.52 -0.1502 -0.2483 2060067 SPBio_000382 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C=C[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D05 compound treatment 244640.0 146000.0 1.24 157240.0 20700.0 0.17 1.0003 0.7968 1002856 SPBio_000383 CCC(C(=O)N)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D06 compound treatment 289120.0 191000.0 1.62 182240.0 45700.0 0.38 1.4144 0.849 3174120 SPBio_000384 CCCCCCCCCCCC[C@@H]([C@@H](C)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D07 compound treatment 22840.0 -75700.0 -0.64 11640.0 -125000.0 -1.03 -1.1867 -0.9742 3078457 SPBio_000385 CN[C@H]1CC[C@@H](c2ccc(Cl)c(Cl)c2)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D08 compound treatment 285760.0 187000.0 1.59 109520.0 -27100.0 -0.22 0.9687 0.6019 1000219 SPBio_000386 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D09 compound treatment 268040.0 169000.0 1.44 130200.0 -6380.0 -0.05 0.983 0.6808 2069284 SPBio_000387 COc1ccc2cc(ccc2c1)[C@H](C)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D10 compound treatment 112840.0 14300.0 0.12 48960.0 -87600.0 -0.72 -0.4266 -0.5804 3177312 SPBio_000388 CC(C)CCCC(C)C1CCC2C3=CC[C@H]4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D11 compound treatment 285960.0 187000.0 1.6 178520.0 41900.0 0.35 1.3736 0.8412 1377 SPBio_000389 CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D12 compound treatment 279880.0 181000.0 1.54 236400.0 99800.0 0.83 1.6756 0.957 1064620 SPBio_000390 COC1=CC23CCCN3CCc4cc5OCOc5cc4C2C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D13 compound treatment 273360.0 175000.0 1.49 251680.0 115000.0 0.95 1.7257 0.9767 1079 SPBio_000391 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D14 compound treatment 281960.0 183000.0 1.56 177200.0 40600.0 0.34 1.3418 0.84 1000141 SPBio_000392 OC[C@H]1O[C@@H](Oc2cc3ccc(=O)oc3cc2O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D15 compound treatment 261160.0 163000.0 1.38 120000.0 -16600.0 -0.14 0.8819 0.6339 2060414 SPBio_000393 OC(=O)c1nc2cc(Cl)c(Cl)cc2nc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D16 compound treatment 173000.0 74400.0 0.63 101680.0 -34900.0 -0.29 0.244 0.3503 2060229 SPBio_000394 Oc1cc(OC(=O)c2cc(O)c(O)c(O)c2)c3C[C@@H](OC(=O)c4cc(O)c(O)c(O)c4)[C@H](Oc3c1)c5cc(O)c(O)c(O)c5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D17 compound treatment 251200.0 153000.0 1.3 98720.0 -37900.0 -0.31 0.6975 0.5218 1000393 SPBio_000395 CN(C)CCc1c[nH]c2ccc(CS(=O)(=O)N3CCCC3)cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D18 compound treatment 236760.0 138000.0 1.18 110080.0 -26500.0 -0.22 0.677 0.5656 2060137 SPBio_000396 COc1ccc(cc1)c2coc3c(OC)c(OC)cc(OC)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D19 compound treatment 270000.0 171000.0 1.46 158400.0 21800.0 0.18 1.1598 0.7885 3055414 SPBio_000397 OC[C@@H]1CCCN2CCCC[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D20 compound treatment 262360.0 164000.0 1.39 172520.0 35900.0 0.3 1.1964 0.839 2060196 SPBio_000398 COc1cc2OCC3Oc4cc5OC(C)(C)C=Cc5c(O)c4C(=O)C3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D21 compound treatment 226680.0 128000.0 1.09 107680.0 -28900.0 -0.24 0.6023 0.5393 2060489 SPBio_000399 C/C=C(/C)\C(=O)O[C@@H]1Cc2c(OC1(C)C)ccc3ccc(=O)oc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D22 compound treatment 61880.0 -36700.0 -0.31 48760.0 -87800.0 -0.73 -0.7346 -0.9289 3078459 SPBio_000400 CCN(CCCc1ccccc1)CCCc2ccccc2.CC(CC(=O)O)(CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D23 mock treatment 167160.0 68600.0 0.58 120200.0 -16400.0 -0.14 0.3172 0.529 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 D24 mock treatment 38640.0 -59900.0 -0.51 92480.0 -44100.0 -0.36 -0.6187 -0.9865 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E01 mock treatment 182800.0 84200.0 0.72 69000.0 -67600.0 -0.56 0.1118 0.123 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E02 mock treatment 139840.0 41300.0 0.35 79720.0 -56900.0 -0.47 -0.0841 -0.1432 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E03 compound treatment 137800.0 39200.0 0.33 92600.0 -44000.0 -0.36 -0.021 -0.0426 2060027 SPBio_000401 CC(=O)O[C@@H]1CC2C(C)(C)[C@@H](O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E04 compound treatment 235360.0 137000.0 1.16 179760.0 43200.0 0.36 1.0762 0.8834 2060441 SPBio_000402 OC(=O)c1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E05 compound treatment 265880.0 167000.0 1.42 185960.0 49400.0 0.41 1.2962 0.8746 2060029 SPBio_000403 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E06 compound treatment 288320.0 190000.0 1.62 201400.0 64800.0 0.54 1.5216 0.8938 2060452 SPBio_000404 CC1(C)O[C@@H]2C[C@](O)(C[C@@H](O)[C@@H]2O1)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E07 compound treatment 269080.0 171000.0 1.45 157080.0 20500.0 0.17 1.1465 0.7844 3173368 SPBio_000405 O=C1CC[C@]2(/C=C/C(=O)NCCCCNCCCNC(=O)\C=C\c3ccc4O[C@@H]2C1)c4c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E08 compound treatment 274360.0 176000.0 1.5 169000.0 32400.0 0.27 1.248 0.8207 2060411 SPBio_000406 O[C@H]1Cc2ccc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E09 compound treatment 310240.0 212000.0 1.8 141360.0 4780.0 0.04 1.3024 0.7224 2060039 SPBio_000407 CC(=CCc1c(O)cc2oc(C)cc(=O)c2c1O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E10 compound treatment 25520.0 -73000.0 -0.62 17320.0 -119000.0 -0.99 -1.1374 -0.9752 2060392 SPBio_000408 CCOc1ccc(cc1)C(=O)c2ccc(O)c(O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E11 compound treatment 179560.0 81000.0 0.69 101760.0 -34800.0 -0.29 0.284 0.3799 2060056 SPBio_000409 COc1cc(O)c2c(=O)cc(C)oc2c1CC=C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E12 compound treatment 264120.0 166000.0 1.41 268560.0 132000.0 1.09 1.7688 0.992 2069228 SPBio_000410 COc1ccc2oc3ccccc3c(=O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E13 compound treatment 301160.0 203000.0 1.73 292880.0 156000.0 1.29 2.1341 0.9899 2060061 SPBio_000411 Cc1cc(=O)c2c(O)c3CCC(C)(C)Oc3cc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E14 compound treatment 284760.0 186000.0 1.59 228400.0 91800.0 0.76 1.6581 0.9432 1050711 SPBio_000412 COc1cc(OC)cc(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E15 compound treatment 234520.0 136000.0 1.16 152640.0 16100.0 0.13 0.9125 0.7831 3058621 SPBio_000413 C[C@H]1C2[C@H](C[C@H]3C4CC=C5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CC[C@@H](C)CN6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E16 compound treatment 210320.0 112000.0 0.95 169280.0 32700.0 0.27 0.8641 0.8735 973 SPBio_000414 COc1ccc(cc1)C2C(=O)c3ccccc3C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E17 compound treatment 275440.0 177000.0 1.51 181120.0 44500.0 0.37 1.3254 0.8549 2060161 SPBio_000415 CC(=C)[C@H]1COc2cc3oc(=O)ccc3cc2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E18 compound treatment 89440.0 -9120.0 -0.08 121720.0 -14900.0 -0.12 -0.1418 -0.9754 360 SPBio_000416 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E19 compound treatment 267760.0 169000.0 1.44 215640.0 79100.0 0.65 1.4811 0.9362 1352641 SPBio_000417 COc1c2ccoc2nc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E20 compound treatment 285320.0 187000.0 1.59 188400.0 51800.0 0.43 1.4275 0.8668 2060502 SPBio_000418 COc1cc(cc(OC)c1O)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E21 compound treatment 233840.0 135000.0 1.15 153760.0 17200.0 0.14 0.9149 0.7884 2060295 SPBio_000419 CC(C)C1COc2cc3oc(=O)ccc3cc2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E22 compound treatment 13880.0 -84700.0 -0.72 10520.0 -126000.0 -1.04 -1.2472 -0.9838 862 SPBio_000420 CCCCCCCCCCCCCCCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E23 mock treatment 188840.0 90300.0 0.77 127800.0 -8780.0 -0.07 0.4922 0.6374 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 E24 mock treatment 49480.0 -49100.0 -0.42 94600.0 -42000.0 -0.35 -0.5411 -0.9958 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F01 mock treatment 197880.0 99300.0 0.85 50560.0 -86000.0 -0.71 0.0948 0.0857 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F02 mock treatment 143400.0 44800.0 0.38 116480.0 -20100.0 -0.17 0.1524 0.3659 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F03 compound treatment 182560.0 84000.0 0.72 105280.0 -31300.0 -0.26 0.3226 0.4241 1140 SPBio_000421 CC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F04 compound treatment 241440.0 143000.0 1.22 182320.0 45700.0 0.38 1.1278 0.8852 3198317 SPBio_000422 CCOC(=O)[C@H](CCc1ccccc1)N[C@H](C)C(=O)N2[C@@H](C[C@@H]3CCCC[C@@H]32)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F05 compound treatment 235520.0 137000.0 1.17 220240.0 83700.0 0.69 1.314 0.969 3173234 SPBio_000423 Cn1c(=O)[nH]c(=O)c2nc[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F06 compound treatment 152080.0 53500.0 0.46 117560.0 -19000.0 -0.16 0.211 0.4376 653 SPBio_000424 Oc1cc2cccc(O)c(=O)c2c(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F07 compound treatment 289840.0 191000.0 1.63 168200.0 31600.0 0.26 1.3366 0.8103 1090658 SPBio_000425 COc1cc(O)c2C(=O)c3c(O)cc(C)cc3C(=O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F08 compound treatment 328160.0 230000.0 1.95 230200.0 93600.0 0.77 1.93 0.9178 1013195 SPBio_000426 Nc1ncnc2[nH]cnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F09 compound treatment 211600.0 113000.0 0.96 139560.0 2980.0 0.02 0.698 0.725 1043296 SPBio_000427 Cc1nccc2c3ccc(O)cc3[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F10 compound treatment 258520.0 160000.0 1.36 147800.0 11200.0 0.09 1.0287 0.7535 3177456 SPBio_000428 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F11 compound treatment 317760.0 219000.0 1.87 262680.0 126000.0 1.04 2.0573 0.9622 3480229 SPBio_000429 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F12 compound treatment 177240.0 78700.0 0.67 162840.0 26300.0 0.22 0.6273 0.8907 1113269 SPBio_000430 CN1Cc2c3OCOc3ccc2C4C(O)Cc5cc6OCOc6cc5C41 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F13 compound treatment 280840.0 182000.0 1.55 392640.0 256000.0 2.12 2.5953 0.9883 1001491 SPBio_000431 CCCc1nc(c(C(=O)OCc2oc(=O)oc2C)n1Cc3ccc(cc3)c4ccccc4c5nn[nH]n5)C(C)(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F14 compound treatment 159880.0 61300.0 0.52 141600.0 5020.0 0.04 0.3985 0.7609 1020463 SPBio_000432 Oc1cc2ccc(=O)oc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F15 compound treatment 287440.0 189000.0 1.61 214320.0 77700.0 0.64 1.5919 0.9191 1000878 SPBio_000433 OCCN1C[C@@H](O)[C@@H](O)C(O)C1CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F16 compound treatment 298480.0 200000.0 1.7 177920.0 41300.0 0.34 1.4454 0.8325 3174244 SPBio_000434 N=c1[nH]c(=O)c2[nH]c(=O)c(=O)[nH]c2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F17 compound treatment 290480.0 192000.0 1.63 193520.0 56900.0 0.47 1.4885 0.8753 1001030 SPBio_000435 Cc1onc(c1c2ccc(cc2)S(=O)(=O)N)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F18 compound treatment 275040.0 176000.0 1.5 197880.0 61300.0 0.51 1.4211 0.8961 1048361 SPBio_000436 c1ccc2c(c1)[nH]c3cnccc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F19 compound treatment 246520.0 148000.0 1.26 232120.0 95500.0 0.79 1.4497 0.9748 3198314 SPBio_000437 CCC1OC(=O)[C@H](C)C(=O)[C@H](C)[C@@H](OC2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(OC)C3(CCCn4cnc(c4)c5cccnc5)C[C@@H](C)C(=O)[C@H](C)[C@H]6N(C3)C(=O)O[C@@]61C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F20 compound treatment 295680.0 197000.0 1.68 209640.0 73100.0 0.6 1.6141 0.9049 2069231 SPBio_000438 CC(=CCc1cc(ccc1O)C(=O)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F21 compound treatment 226160.0 128000.0 1.09 178880.0 42300.0 0.35 1.0157 0.8898 1002855 SPBio_000439 CCC(C(=O)O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F22 compound treatment 163520.0 65000.0 0.55 96720.0 -39900.0 -0.33 0.1579 0.2452 819 SPBio_000440 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F23 mock treatment 165520.0 67000.0 0.57 116080.0 -20500.0 -0.17 0.2832 0.4761 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 F24 mock treatment 36040.0 -62500.0 -0.53 78800.0 -57800.0 -0.48 -0.7144 -0.9986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G01 mock treatment 135800.0 37200.0 0.32 72880.0 -63700.0 -0.53 -0.1484 -0.2413 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G02 mock treatment 115160.0 16600.0 0.14 68120.0 -68500.0 -0.57 -0.3005 -0.5148 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G03 compound treatment 152320.0 53800.0 0.46 93720.0 -42900.0 -0.35 0.0729 0.126 2060058 SPBio_000441 CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@@H](O)C(C)(C)C5CC[C@]43C)C2C1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G04 compound treatment 14840.0 -83700.0 -0.71 13400.0 -123000.0 -1.02 -1.2246 -0.9847 1057125 SPBio_000442 CC(C)(C=C)c1c2OC(C)(C)C=Cc2c(O)c3c(=O)c4ccc(O)c(O)c4oc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G05 compound treatment 245040.0 146000.0 1.25 241640.0 105000.0 0.87 1.4964 0.9844 3173478 SPBio_000443 C[C@H]1C(=O)CCC2[C@]1(C)CCC3[C@@]2(C)CC[C@@]4(C)C5CC(C)(C)CC[C@]5(C)CC[C@]34C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G06 compound treatment 114600.0 16000.0 0.14 116760.0 -19800.0 -0.16 -0.0194 -0.0908 3173115 SPBio_000444 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@]61CCC(C)CN6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G07 compound treatment 255160.0 157000.0 1.33 219880.0 83300.0 0.69 1.4301 0.9528 3054135 SPBio_000445 CC(=O)O[C@H]1CC[C@@]2(C)C(CC[C@]3(C)C2CC=C4C5CC(C)(C)CC[C@]5(C)CC[C@]43C)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G08 compound treatment 45800.0 -52800.0 -0.45 39240.0 -97300.0 -0.81 -0.8871 -0.962 2060429 SPBio_000446 COC1CC(O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)C(CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)OC(C)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G09 compound treatment 307560.0 209000.0 1.78 226720.0 90100.0 0.75 1.7856 0.9254 2060065 SPBio_000447 COC[C@@]12CN(C=O)C3[C@@H]4[C@H](OC)C2[C@]3(C5CC6(O)C(OC(=O)c7ccccc7)C5C4(OC(=O)C)C(O)C6OC)[C@H](C[C@H]1O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G10 compound treatment 301840.0 203000.0 1.73 264040.0 127000.0 1.05 1.9694 0.9718 1082254 SPBio_000448 OC(=O)CCNC(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G11 compound treatment 277120.0 179000.0 1.52 300760.0 164000.0 1.36 2.0354 0.9984 2060068 SPBio_000449 COC1C(O)C(O[C@H]2CC[C@]3(C=O)C4[C@@H](C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)OC(=O)C)OC(C)C1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G12 compound treatment 23160.0 -75400.0 -0.64 23680.0 -113000.0 -0.93 -1.1144 -0.9833 1001284 SPBio_000450 CC(C)C1NC(=O)C(NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)NC5C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C6CCCC6C(=O)C(NC5=O)C(C)C)c4nc23)C(C)OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C7CCCC7C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G13 compound treatment 222080.0 124000.0 1.05 247520.0 111000.0 0.92 1.3926 0.9977 3174249 SPBio_000451 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G14 compound treatment 23200.0 -75400.0 -0.64 22240.0 -114000.0 -0.95 -1.1226 -0.9821 2069274 SPBio_000452 CC(O)c1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5CCC(=O)O)c(CCC(=O)O)c4C)c(C)c3C(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G15 compound treatment 255320.0 157000.0 1.33 240120.0 104000.0 0.86 1.5494 0.977 2060088 SPBio_000453 COc1cc2ccc(=O)oc2c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G16 compound treatment 238720.0 140000.0 1.19 220880.0 84300.0 0.7 1.337 0.9673 840 SPBio_000454 CCOc1ccc2ccccc2c1NC(=O)[C@H]3[C@H]4SC(C)(C)C(N4C3=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G17 compound treatment 240800.0 142000.0 1.21 223120.0 86500.0 0.72 1.3626 0.9685 2060292 SPBio_000455 CC1(C)[C@H](O)C[C@H](O)[C@@]2(C)C1C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G18 compound treatment 241160.0 143000.0 1.21 205840.0 69300.0 0.57 1.2637 0.9413 1041649 SPBio_000456 CC(C)c1ccc(C)c(C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G19 compound treatment 242480.0 144000.0 1.23 223000.0 86400.0 0.71 1.372 0.9671 3472730 SPBio_000457 CC12CCC3C(CC=C4CC(O)CCC34C)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G20 compound treatment 235080.0 137000.0 1.16 126000.0 -10600.0 -0.09 0.76 0.652 1001523 SPBio_000458 Nc1ccc(C(=O)Oc2ccccc2)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G21 compound treatment 234880.0 136000.0 1.16 205520.0 68900.0 0.57 1.224 0.9465 3054130 SPBio_000459 CC(CCC=C(C)C)[C@@H]1CC[C@]2(C)C3=C(CC[C@@]12C)C4(C)CC[C@H](OC(=O)C)C(C)(C)C4CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G22 compound treatment 105320.0 6760.0 0.06 95760.0 -40800.0 -0.34 -0.1981 -0.5782 2060420 SPBio_000460 CC(=O)O[C@@H]1CC2C(C)(C)[C@@H](O)CCC2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4C13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G23 mock treatment 179640.0 81100.0 0.69 134480.0 -2100.0 -0.02 0.4759 0.6891 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 G24 mock treatment 17240.0 -81300.0 -0.69 81440.0 -55100.0 -0.46 -0.8121 -0.9795 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H01 mock treatment 65400.0 -33200.0 -0.28 86920.0 -49700.0 -0.41 -0.4901 -0.9832 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H02 mock treatment 122880.0 24300.0 0.21 111240.0 -25300.0 -0.21 -0.0018 -0.0062 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H03 compound treatment 151440.0 52900.0 0.45 103680.0 -32900.0 -0.27 0.1259 0.2393 1235 SPBio_000461 CCOC(=O)CCCCCCCCCCCCC1CCC=C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H04 compound treatment 105440.0 6880.0 0.06 102680.0 -33900.0 -0.28 -0.1569 -0.5476 2565 SPBio_000462 COC1=CC(=O)OC1(O)C(=C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H05 compound treatment 243640.0 145000.0 1.24 223880.0 87300.0 0.72 1.3841 0.9673 1384 SPBio_000463 COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H06 compound treatment 274080.0 176000.0 1.49 246800.0 110000.0 0.91 1.7015 0.9719 2060149 SPBio_000464 Cc1cc(O)c2C(=O)c3c(O)cccc3Cc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H07 compound treatment 229880.0 131000.0 1.12 221880.0 85300.0 0.71 1.2896 0.9754 1044852 SPBio_000465 OC(=O)c1cc2cc(Cl)ccc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H08 compound treatment 214320.0 116000.0 0.99 213000.0 76400.0 0.63 1.144 0.977 715 SPBio_000466 COc1c2ccoc2c(OC)c3oc(C)cc(=O)c13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H09 compound treatment 21720.0 -76800.0 -0.65 24200.0 -112000.0 -0.93 -1.12 -0.9852 3078458 SPBio_000467 CCCCCC/C=C\CCCCCCCc1cccc(O)c1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H10 compound treatment 265160.0 167000.0 1.42 276200.0 140000.0 1.16 1.8197 0.9948 886 SPBio_000468 O[C@@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H11 compound treatment 255000.0 156000.0 1.33 273120.0 137000.0 1.13 1.7406 0.9966 710 SPBio_000469 CC(=O)OCC1=C(N2C(SC1)[C@H](NC(=O)CCCC(N)C(=O)O)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H12 compound treatment 173320.0 74800.0 0.64 179360.0 42800.0 0.35 0.7003 0.9616 1737132 SPBio_000470 COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c2c34)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H13 compound treatment 273000.0 174000.0 1.49 300440.0 164000.0 1.36 2.0087 0.999 1001994 SPBio_000471 C[C@@H](N)[C@@H](O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H14 compound treatment 260080.0 162000.0 1.38 287800.0 151000.0 1.25 1.857 0.9989 4895 SPBio_000472 C[n+]1cccc(c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H15 compound treatment 248800.0 150000.0 1.28 262720.0 126000.0 1.04 1.6424 0.9949 1004889 SPBio_000473 CC(=O)Nc1cccc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H16 compound treatment 19360.0 -79200.0 -0.67 33360.0 -103000.0 -0.85 -1.0806 -0.9932 2060141 SPBio_000474 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccc(OC)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H17 compound treatment 278000.0 179000.0 1.53 238920.0 102000.0 0.85 1.679 0.9612 954 SPBio_000475 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H18 compound treatment 245400.0 147000.0 1.25 233280.0 96700.0 0.8 1.4497 0.9767 1539748 SPBio_000476 COc1ccccc1c2coc3cc(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H19 compound treatment 298600.0 200000.0 1.7 313320.0 177000.0 1.46 2.2382 0.9971 906 SPBio_000477 N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H20 compound treatment 220160.0 122000.0 1.04 214320.0 77700.0 0.64 1.1868 0.9738 1010377 SPBio_000478 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H21 compound treatment 158880.0 60300.0 0.51 160520.0 23900.0 0.2 0.5032 0.9142 2069291 SPBio_000479 COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H22 compound treatment 228960.0 130000.0 1.11 173680.0 37100.0 0.31 1.0021 0.8699 3055310 SPBio_000480 COc1c(O)cc2C(=O)O[C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]3c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H23 mock treatment 135560.0 37000.0 0.32 171480.0 34900.0 0.29 0.4269 0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 H24 mock treatment 6000.0 -92600.0 -0.79 82480.0 -54100.0 -0.45 -0.8737 -0.9641 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I01 mock treatment 52400.0 -46200.0 -0.39 111160.0 -25400.0 -0.21 -0.4266 -0.9571 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I02 mock treatment 112040.0 13500.0 0.11 135480.0 -1100.0 -0.01 0.0747 0.6489 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I03 compound treatment 36560.0 -62000.0 -0.53 34000.0 -103000.0 -0.85 -0.9733 -0.9739 3173612 SPBio_000481 CC(=O)OC1CC2(O)C3CCC4CC(CC[C@]4(C)C3CC[C@]2(C)C1C5=CC(=O)OC5)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I04 compound treatment 210480.0 112000.0 0.95 218200.0 81600.0 0.68 1.1513 0.9858 2060151 SPBio_000482 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)[C@H](C[C@@H](OC(=O)C)C(C)(C)C5C[C@H](O)[C@]43C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I05 compound treatment 222040.0 123000.0 1.05 233000.0 96400.0 0.8 1.3074 0.9907 2060096 SPBio_000483 CC(=O)O[C@@H]1CC(=O)[C@@]2(C)C(CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I06 compound treatment 206960.0 108000.0 0.92 236280.0 99700.0 0.82 1.2358 0.9984 2060396 SPBio_000484 OC[C@H]1O[C@@H](Oc2ccc(C(=O)/C=C/c3ccccc3)c(O)c2)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I07 compound treatment 233640.0 135000.0 1.15 221800.0 85200.0 0.7 1.3118 0.9724 2060098 SPBio_000485 C[C@@]12CCC3C(CC[C@H]4C[C@@H](Cl)CC[C@@]43C)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I08 compound treatment 211400.0 113000.0 0.96 240160.0 104000.0 0.86 1.2853 0.9984 2060410 SPBio_000486 CC1(C)[C@H](O)CC(=O)[C@@]2(C)C1C[C@@H](O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I09 compound treatment 224760.0 126000.0 1.07 256920.0 120000.0 1.0 1.4637 0.9993 2060114 SPBio_000487 COc1c2OCOc2cc3cc[n+](C)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I10 compound treatment 169960.0 71400.0 0.61 227000.0 90400.0 0.75 0.9588 0.9947 1503 SPBio_000488 Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I11 compound treatment 261880.0 163000.0 1.39 312920.0 176000.0 1.46 2.0148 0.9997 2060122 SPBio_000489 CC1(C)Oc2cc3oc(=O)ccc3cc2C=C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I12 compound treatment 206480.0 108000.0 0.92 229800.0 93200.0 0.77 1.195 0.9962 3077356 SPBio_000490 COc1cc(cc(OC)c1O)[C@H]2C3C(COC3=O)[C@H](O)c4cc5OCOc5cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I13 compound treatment 22880.0 -75700.0 -0.64 25720.0 -111000.0 -0.92 -1.1041 -0.9851 2060124 SPBio_000491 COC(=O)[C@@]1(C)CCC[C@@]2(C)C1CCc3c(C(C)C)c(O)ccc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I14 compound treatment 236000.0 137000.0 1.17 278640.0 142000.0 1.18 1.6585 1.0 1837 SPBio_000492 CS(=O)(=O)c1ccc(cc1)C2=C(C(=O)OC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I15 compound treatment 214800.0 116000.0 0.99 271320.0 135000.0 1.11 1.488 0.9982 2060128 SPBio_000493 CO[C@@H]1C(OC(=O)C(C)C)[C@@]2(C)[C@@H](OC(=O)/C(=C(\OC)/C(C)C)/C2[C@@]34OC5(C)O[C@]14[C@]6(C)[C@@H](CC(=O)OC)C7(C)CC6(O5)[C@](OC)(C7OC(=O)C)[C@H]3OC)c8ccoc8 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I16 compound treatment 215960.0 117000.0 1.0 260680.0 124000.0 1.03 1.4328 0.9999 750 SPBio_000494 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1OC2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I17 compound treatment 181560.0 83000.0 0.71 257200.0 121000.0 1.0 1.2053 0.9857 2060146 SPBio_000495 C[C@@]12CCC(=O)C=C2CCc3ccc(O)cc31 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I18 compound treatment 120080.0 21500.0 0.18 180520.0 43900.0 0.36 0.3866 0.9497 1358 SPBio_000496 CN(CCCl)CCCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I19 compound treatment 238840.0 140000.0 1.19 285760.0 149000.0 1.23 1.7172 0.9999 2060157 SPBio_000497 CC(=O)C1CCC2C3CCC4C[C@H](O)CCC4(C)C3C[C@H](O)C12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I20 compound treatment 248800.0 150000.0 1.28 221400.0 84800.0 0.7 1.4007 0.96 1913604 SPBio_000498 OC(=O)CCCN1C(=O)c2cccc3cccc(C1=O)c23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I21 compound treatment 186760.0 88200.0 0.75 221440.0 84900.0 0.7 1.0274 0.9994 2060159 SPBio_000499 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)CCC(=O)C(C)(C)C5C[C@@H](OC(=O)C)[C@]43C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I22 compound treatment 148240.0 49700.0 0.42 84680.0 -51900.0 -0.43 -0.0045 -0.0075 3055336 SPBio_000500 Oc1ccc2sc(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I23 mock treatment 112440.0 13900.0 0.12 125640.0 -10900.0 -0.09 0.0196 0.1314 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 I24 mock treatment 6080.0 -92500.0 -0.79 108840.0 -27700.0 -0.23 -0.7191 -0.8767 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J01 mock treatment 45040.0 -53500.0 -0.46 166640.0 30100.0 0.25 -0.1464 -0.282 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J02 mock treatment 110880.0 12300.0 0.1 161400.0 24800.0 0.21 0.2194 0.9514 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J03 compound treatment 183000.0 84400.0 0.72 194480.0 57900.0 0.48 0.8471 0.9805 3198315 SPBio_000501 COc1ccc(cc1F)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J04 compound treatment 226720.0 128000.0 1.09 244840.0 108000.0 0.9 1.4049 0.9952 989 SPBio_000502 NC(=N)NCCCCNC(=N)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J05 compound treatment 215200.0 117000.0 0.99 237600.0 101000.0 0.84 1.2932 0.9963 1439 SPBio_000503 CSCCC(N)C(=O)NC(CC(C)C)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J06 compound treatment 17040.0 -81500.0 -0.69 20960.0 -116000.0 -0.96 -1.1671 -0.9876 2060167 SPBio_000504 COC(=O)c1cc(O)c(=O)c2c(O)c(O)ccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J07 compound treatment 182600.0 84000.0 0.72 242360.0 106000.0 0.88 1.1247 0.995 3060196 SPBio_000505 COc1c(CN2CC[C@@H]3CCCN[C@@H]3C2)c(F)cc4c(=O)c(cn(C5CC5)c14)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J08 compound treatment 174040.0 75500.0 0.64 200600.0 64000.0 0.53 0.8289 0.9954 926 SPBio_000506 Oc1cccc2C(=O)c3cccc(O)c3C(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J09 compound treatment 212640.0 114000.0 0.97 284400.0 148000.0 1.22 1.5515 0.9935 1449108 SPBio_000507 Cc1ccc2c(Cl)cc(Cl)c(O)c2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J10 compound treatment 218920.0 120000.0 1.02 300640.0 164000.0 1.36 1.6843 0.9904 3055321 SPBio_000508 CC(CCC(=O)O)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J11 compound treatment 253040.0 154000.0 1.32 331520.0 195000.0 1.61 2.0704 0.9949 913 SPBio_000509 O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)n2ccc(=O)[nH]c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J12 compound treatment 324880.0 226000.0 1.93 391480.0 255000.0 2.11 2.8536 0.999 1055132 SPBio_000510 COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J13 compound treatment 211880.0 113000.0 0.96 233600.0 97000.0 0.8 1.2498 0.9958 3480078 SPBio_000511 CC(C)N(CCC(c1ccccc1)c2cc(C)ccc2O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J14 compound treatment 236360.0 138000.0 1.17 320440.0 184000.0 1.52 1.9051 0.9918 2069273 SPBio_000512 N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J15 compound treatment 188240.0 89700.0 0.76 285920.0 149000.0 1.24 1.4135 0.9733 2060469 SPBio_000513 C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)C)C3(C)C[C@H](O)C2C4(C)C=CC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J16 compound treatment 14160.0 -84400.0 -0.72 23000.0 -114000.0 -0.94 -1.1725 -0.9912 3177314 SPBio_000514 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CCC=C4C(=O)c3c(O)c2C=C1)[C@@](C/C=C(\C)/C(=O)O)(OC5(C)C)C(=O)O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J17 compound treatment 26120.0 -72400.0 -0.62 134800.0 -1780.0 -0.01 -0.4465 -0.7238 2069250 SPBio_000515 OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J18 compound treatment 241560.0 143000.0 1.22 371640.0 235000.0 1.94 2.236 0.9746 1084508 SPBio_000516 COc1ccc2cc3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J19 compound treatment 228560.0 130000.0 1.11 267600.0 131000.0 1.08 1.5491 0.9999 3198316 SPBio_000517 C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(OCCO)cc(O)c4c3=O)c5ccc(OCCO)c(OCCO)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J20 compound treatment 110480.0 11900.0 0.1 208760.0 72200.0 0.6 0.494 0.8156 2069242 SPBio_000518 CC(=CCc1cc(cc(CC=C(C)C)c1O)C(=O)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J21 compound treatment 47480.0 -51100.0 -0.43 17240.0 -119000.0 -0.99 -1.0056 -0.9322 702 SPBio_000519 CCCCCC(=O)O[C@@]1(CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J22 compound treatment 100640.0 2080.0 0.02 136840.0 259.0 0.0 0.014 0.7868 3172733 SPBio_000520 Cc1c(C(=O)O)c(O)cc2C(=O)c3c(O)c(O)c(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(O)c3C(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J23 mock treatment 145360.0 46800.0 0.4 194440.0 57900.0 0.48 0.6202 0.9958 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 J24 mock treatment 29440.0 -69100.0 -0.59 168480.0 31900.0 0.26 -0.2295 -0.3559 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K01 mock treatment 47240.0 -51300.0 -0.44 193760.0 57200.0 0.47 0.0255 0.0396 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K02 mock treatment 98000.0 -559.0 0.0 187920.0 51300.0 0.42 0.2969 0.6991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K03 compound treatment 140280.0 41700.0 0.36 175040.0 38500.0 0.32 0.4762 0.9985 2060184 SPBio_000521 CC1CCc2c(O)c3c(=O)cc(C)oc3cc2OC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K04 compound treatment 187520.0 89000.0 0.76 241920.0 105000.0 0.87 1.1518 0.9976 3173993 SPBio_000522 O[C@H]1CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K05 compound treatment 183600.0 85000.0 0.72 237760.0 101000.0 0.84 1.1039 0.9974 2060185 SPBio_000523 COc1ccc2[C@@H]3COc4cc(OC)ccc4[C@@H]3Oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K06 compound treatment 13600.0 -85000.0 -0.72 18080.0 -119000.0 -0.98 -1.2047 -0.9888 2069260 SPBio_000524 CC[C@@]1(O)C[C@H](O)c2c(O)c3C(=O)c4c(O)ccc(O)c4C(=O)c3cc2[C@H]1C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K07 compound treatment 31480.0 -67100.0 -0.57 37400.0 -99200.0 -0.82 -0.984 -0.9843 2060186 SPBio_000525 CC(=O)OC1CCC2(C3CCC4(C)C(CCC54OC2=O)C6=CC(=O)OC6)C(O)(CCC35)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K08 compound treatment 204240.0 106000.0 0.9 311480.0 175000.0 1.45 1.6594 0.9739 2060406 SPBio_000526 COc1ccccc1/C=C\C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K09 compound treatment 196040.0 97500.0 0.83 272480.0 136000.0 1.12 1.3818 0.9889 2060446 SPBio_000527 CC1(C)[C@@H](O)C=C[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]543)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K10 compound treatment 221240.0 123000.0 1.04 335320.0 199000.0 1.64 1.9012 0.976 3174367 SPBio_000528 NCCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K11 compound treatment 169040.0 70500.0 0.6 304040.0 167000.0 1.39 1.4039 0.9299 2060390 SPBio_000529 CC(=O)O[C@H]1CC[C@@]2(C)C(C[C@H](OC(=O)C)[C@]3(C)C2CC[C@@]4(C)C(OC(=O)C=C43)c5ccoc5)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K12 compound treatment 234520.0 136000.0 1.16 332440.0 196000.0 1.62 1.9643 0.9864 2060082 SPBio_000530 COC(=O)c1cc(OC)c(=O)c2c(OC)c(OC)ccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K13 compound treatment 269920.0 171000.0 1.46 271560.0 135000.0 1.12 1.8213 0.9913 1111461 SPBio_000531 CC(=CCOc1c2occc2cc3ccc(=O)oc13)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K14 compound treatment 278440.0 180000.0 1.53 393960.0 257000.0 2.13 2.5886 0.9869 1054271 SPBio_000532 COc1ccc(cc1O)c2cc(=O)c3c(O)c(OC)c(OC)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K15 compound treatment 176320.0 77800.0 0.66 285960.0 149000.0 1.24 1.342 0.9572 3174000 SPBio_000533 C[C@H]1[C@H]2[C@H](CC3C4CC[C@@H]5C[C@@H](O)CC[C@]5(C)C4CC[C@]23C)O[C@@]61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K16 compound treatment 76080.0 -22500.0 -0.19 139000.0 2420.0 0.02 -0.1212 -0.6297 1527 SPBio_000534 COc1cc2OC[C@H]3Oc4c5C[C@@H](Oc5ccc4C(=O)[C@H]3c2cc1OC)C(=C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K17 compound treatment 153040.0 54500.0 0.46 323320.0 187000.0 1.54 1.4204 0.8806 3173615 SPBio_000535 CCC(CCC(C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K18 compound treatment 197960.0 99400.0 0.85 291560.0 155000.0 1.28 1.505 0.9797 1001 SPBio_000536 CN(C)CCOC(=O)COc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K19 compound treatment 237240.0 139000.0 1.18 320520.0 184000.0 1.52 1.9109 0.9921 2060206 SPBio_000537 CCC(CCC(C)C1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K20 compound treatment 204640.0 106000.0 0.9 295680.0 159000.0 1.32 1.5693 0.9831 1065857 SPBio_000538 NC(CNC(=O)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K21 compound treatment 99000.0 441.0 0.0 177840.0 41300.0 0.34 0.244 0.7148 2069265 SPBio_000539 C[C@@]12CCC3C(CC[C@H]4CC(=O)CC[C@@]43C)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K22 compound treatment 8480.0 -90100.0 -0.77 13920.0 -123000.0 -1.01 -1.2599 -0.9905 981 SPBio_000540 CCCCCCCCCCCCCCCC[n+]1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K23 mock treatment 104200.0 5640.0 0.05 168840.0 32300.0 0.27 0.2227 0.8212 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 K24 mock treatment 34280.0 -64300.0 -0.55 200920.0 64300.0 0.53 -0.0106 -0.0139 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L01 mock treatment 46080.0 -52500.0 -0.45 166320.0 29700.0 0.25 -0.142 -0.2784 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L02 mock treatment 109400.0 10800.0 0.09 209520.0 72900.0 0.6 0.4919 0.8059 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L03 compound treatment 111240.0 12700.0 0.11 201800.0 65200.0 0.54 0.4579 0.8321 1009258 SPBio_000541 O=C1NC(=O)C(=O)C(=O)N1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L04 compound treatment 87560.0 -11000.0 -0.09 191960.0 55400.0 0.46 0.2577 0.5512 2069264 SPBio_000542 C[C@@]12CCC3C(CC[C@H]4C[C@@H](O)CC[C@@]43C)C2CC[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L05 compound treatment 173960.0 75400.0 0.64 265680.0 129000.0 1.07 1.2091 0.9703 857 SPBio_000543 O=C(OCc1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L06 compound treatment 192120.0 93600.0 0.8 282840.0 146000.0 1.21 1.4189 0.9794 1009367 SPBio_000544 OC1=CC2=C3c4ccc(O)c(O)c4OCC3(O)CC2=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L07 compound treatment 35680.0 -62900.0 -0.54 41560.0 -95000.0 -0.79 -0.9344 -0.9825 1021 SPBio_000545 CO[C@@H]1[C@@H](O)[C@H](C)O[C@@H](O[C@H]2CC[C@@]3(C)[C@H](CCC4C3CC[C@]5(C)C(CC[C@]45O)C6=CC(=O)OC6)C2)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L08 compound treatment 195880.0 97300.0 0.83 292160.0 156000.0 1.29 1.496 0.9773 991 SPBio_000546 CC[C@@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L09 compound treatment 185520.0 87000.0 0.74 254480.0 118000.0 0.98 1.2132 0.9908 1147 SPBio_000547 COc1c2ccoc2cc3oc(=O)ccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L10 compound treatment 158480.0 59900.0 0.51 313120.0 177000.0 1.46 1.3934 0.9007 1000126 SPBio_000548 C[C@H](CCC(=O)O)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L11 compound treatment 16360.0 -82200.0 -0.7 30080.0 -107000.0 -0.88 -1.1179 -0.9935 2060361 SPBio_000549 C/C=C(/C)\C(=O)O[C@@H]1[C@H](OC(=O)C)[C@]2(CO)[C@H](O)C[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@H]6O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(=O)O)[C@](C)(CO)C5CC[C@]43C)C2CC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L12 compound treatment 212960.0 114000.0 0.97 349360.0 213000.0 1.76 1.9334 0.9611 2060057 SPBio_000550 COC(=O)C[C@H]1C(C)(C)[C@@H](OC(=O)C)[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@@]1(C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L13 compound treatment 257280.0 159000.0 1.35 314960.0 178000.0 1.48 1.999 0.999 2060456 SPBio_000551 C[C@@H]1CC(Cl)CC[C@H]1C(=O)OC(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L14 compound treatment 209960.0 111000.0 0.95 287360.0 151000.0 1.25 1.5527 0.9909 2060413 SPBio_000552 CC(C)CCCC(C)[C@H]1CCC2C3CC[C@H]4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L15 compound treatment 98760.0 201.0 0.0 391520.0 255000.0 2.11 1.4925 0.7077 2060378 SPBio_000553 Oc1nc2cc(Cl)c(Cl)cc2nc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L16 compound treatment 148120.0 49600.0 0.42 312800.0 176000.0 1.46 1.3292 0.8758 1011559 SPBio_000554 Cc1cc(=O)oc2cc(O)c(O)cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L17 compound treatment 127240.0 28700.0 0.24 410680.0 274000.0 2.27 1.7761 0.7788 3055475 SPBio_000555 COc1ccc(/C=C/C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L18 compound treatment 109920.0 11400.0 0.1 239360.0 103000.0 0.85 0.6696 0.7825 2060366 SPBio_000556 CC1(C)C=CC(=O)[C@@]2(C)C1CC(=O)[C@]3(C)C2CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L19 compound treatment 169560.0 71000.0 0.6 360600.0 224000.0 1.85 1.7379 0.8915 1187 SPBio_000557 C[C@@]12CCC3C(CCc4cc(OS(=O)(=O)O)ccc34)C2CC[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L20 compound treatment 11320.0 -87200.0 -0.74 21760.0 -115000.0 -0.95 -1.1969 -0.9926 2060045 SPBio_000558 CC(=C)/C=C\1/C=CC(=O)C(=C1)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L21 compound treatment 126760.0 28200.0 0.24 231920.0 95300.0 0.79 0.7275 0.8824 1052338 SPBio_000559 COc1cc2C(C)NCCc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L22 compound treatment 84000.0 -14600.0 -0.12 165680.0 29100.0 0.24 0.0826 0.3049 3172727 SPBio_000560 CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L23 mock treatment 90600.0 -7960.0 -0.07 184440.0 47900.0 0.4 0.232 0.5777 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 L24 mock treatment 34920.0 -63600.0 -0.54 197800.0 61200.0 0.51 -0.025 -0.0337 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M01 mock treatment 48760.0 -49800.0 -0.42 189480.0 52900.0 0.44 0.0096 0.0158 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M02 mock treatment 104960.0 6400.0 0.05 190440.0 53900.0 0.45 0.3536 0.7877 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M03 compound treatment 82680.0 -15900.0 -0.14 183680.0 47100.0 0.39 0.1799 0.4362 2060155 SPBio_000561 COC(=O)[C@@H]1OC(=O)C2OC23[C@@]1(C)CCC4[C@@]5(C)[C@H](C[C@@H](OC(=O)C)C(C)(C)C5C[C@@H](O)[C@]43C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M04 compound treatment 8000.0 -90600.0 -0.77 16320.0 -120000.0 -0.99 -1.2487 -0.9921 2060215 SPBio_000562 CC1(C)C2C=C[C@]3(C)C(CC[C@@]4(C)[C@@H](OC(=O)C5OC543)c6ccoc6)[C@@]2(C)C=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M05 compound treatment 7680.0 -90900.0 -0.77 21040.0 -116000.0 -0.96 -1.223 -0.9945 1010376 SPBio_000563 Oc1ccc2C3c4cc(O)c(O)cc4CC3(O)COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M06 compound treatment 69480.0 -29100.0 -0.25 109760.0 -26800.0 -0.22 -0.332 -0.9985 3173759 SPBio_000564 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(OC4O[C@@H]5COC(C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M07 compound treatment 110200.0 11600.0 0.1 264840.0 128000.0 1.06 0.8204 0.7698 1326 SPBio_000565 CC1(C)[C@@H]2CC[C@@]1(C)C(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M08 compound treatment 123840.0 25300.0 0.22 290720.0 154000.0 1.28 1.0539 0.8149 1015281 SPBio_000566 COc1cc(O)c(C(=O)C)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M09 compound treatment 144640.0 46100.0 0.39 284160.0 148000.0 1.22 1.1407 0.8895 1570 SPBio_000567 CCCC(C)C1(CC=C)C(=O)NC(=NC1=O)S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M10 compound treatment 12760.0 -85800.0 -0.73 28000.0 -109000.0 -0.9 -1.1517 -0.9947 1473 SPBio_000568 CC1(C)[C@@H](O)CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M11 compound treatment 161400.0 62800.0 0.54 273720.0 137000.0 1.13 1.1806 0.9412 2060408 SPBio_000569 COC(=O)C[C@H]1C(C)(C)[C@H](C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M12 compound treatment 176560.0 78000.0 0.66 268240.0 132000.0 1.09 1.2398 0.9718 2069338 SPBio_000570 CC(=O)O[C@@H]1Cc2c(OC(=O)C)cc(OC(=O)C)cc2O[C@@H]1c3ccc(OC(=O)C)c(OC(=O)C)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M13 compound treatment 242200.0 144000.0 1.22 326320.0 190000.0 1.57 1.9747 0.9924 1050335 SPBio_000571 COc1cc(OC)c(C=O)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M14 compound treatment 117320.0 18800.0 0.16 210840.0 74300.0 0.61 0.5473 0.8623 1950 SPBio_000572 Oc1cc2oc(cc(=O)c2c(O)c1O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M15 compound treatment 113720.0 15200.0 0.13 239560.0 103000.0 0.85 0.6937 0.8051 3198311 SPBio_000573 Cc1cc(O)c(C=O)c2Oc3c(C)c(C(=O)O)c(O)c(COC(=O)/C=C/C(=O)O)c3OC(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M16 compound treatment 100200.0 1640.0 0.01 294680.0 158000.0 1.31 0.9347 0.7146 832189 SPBio_000574 CC(=O)CC(=O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M17 compound treatment 9400.0 -89200.0 -0.76 23760.0 -113000.0 -0.93 -1.1968 -0.9947 1597 SPBio_000575 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M18 compound treatment 101160.0 2600.0 0.02 264280.0 128000.0 1.06 0.7627 0.7218 780 SPBio_000576 CC(C)NNC(=O)c1ccncc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M19 compound treatment 137360.0 38800.0 0.33 300560.0 164000.0 1.36 1.1928 0.8543 2060116 SPBio_000577 CCC(=O)OC1[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@](C)([C@@H](CC(=O)OC)C1(C)C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M20 compound treatment 141720.0 43200.0 0.37 246880.0 110000.0 0.91 0.9051 0.9201 3173091 SPBio_000578 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)C(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3OC4O[C@H](CN)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M21 compound treatment 138160.0 39600.0 0.34 266040.0 129000.0 1.07 0.9957 0.8868 1071570 SPBio_000579 CCOC(=O)c1c(C)cc(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M22 compound treatment 105760.0 7200.0 0.06 206800.0 70200.0 0.58 0.4541 0.7774 3172862 SPBio_000580 O=c1cccc2C3CNC[C@@H](C3)Cn21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M23 mock treatment 86960.0 -11600.0 -0.1 153440.0 16900.0 0.14 0.0288 0.1684 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 M24 mock treatment 63960.0 -34600.0 -0.29 192560.0 56000.0 0.46 0.1192 0.2171 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N01 mock treatment 74240.0 -24300.0 -0.21 170520.0 33900.0 0.28 0.0521 0.1494 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N02 mock treatment 89320.0 -9240.0 -0.08 215560.0 79000.0 0.65 0.4064 0.6175 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N03 compound treatment 85160.0 -13400.0 -0.11 194360.0 57800.0 0.48 0.2573 0.5236 3471725 SPBio_000581 CC1(C)SC2C(NC(=O)C(N=C)c3ccccc3)C(=O)N2C1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N04 compound treatment 43560.0 -55000.0 -0.47 71040.0 -65500.0 -0.54 -0.7145 -0.9973 3173106 SPBio_000582 COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2c(C)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N05 compound treatment 72960.0 -25600.0 -0.22 245960.0 109000.0 0.9 0.4857 0.5219 3474304 SPBio_000583 COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N06 compound treatment 97080.0 -1480.0 -0.01 259240.0 123000.0 1.01 0.7086 0.6983 2069253 SPBio_000584 CC(C)/C(=C/1\C2[C@@]34OC5(C)O[C@@]4([C@H](O)C(O)[C@@]2(C)[C@@H](OC1=O)c6ccoc6)[C@]7(C)[C@@H](CC(=O)O)C8(C)CC7(O5)[C@](O)(C8O)[C@H]3O)/O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N07 compound treatment 10760.0 -87800.0 -0.75 21680.0 -115000.0 -0.95 -1.2007 -0.9929 1001621 SPBio_000585 Oc1cc(cc(O)c1O)C(=O)Oc2cc(cc(O)c2O)C(=O)OC[C@H]3O[C@H](OC(=O)c4cc(O)c(O)c(OC(=O)c5cc(O)c(O)c(O)c5)c4)[C@H](OC(=O)c6cc(O)c(O)c(OC(=O)c7cc(O)c(O)c(O)c7)c6)[C@@H](OC(=O)c8cc(O)c(O)c(OC(=O)c9cc(O)c(O)c(O)c9)c8)[C@@H]3OC(=O)c%10cc(O)c(O)c(OC(=O)c%11cc(O)c(O)c(O)c%11)c%10 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N08 compound treatment 85720.0 -12800.0 -0.11 263720.0 127000.0 1.05 0.6664 0.6302 1101 SPBio_000586 CCCC1O[C@@H]2CC3C4CCC5=CC(=O)C=CC5(C)C4[C@@H](O)CC3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N09 compound treatment 100600.0 2040.0 0.02 283080.0 146000.0 1.21 0.8693 0.7172 789 SPBio_000587 C[N+]1(C)C2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N10 compound treatment 108280.0 9720.0 0.08 287520.0 151000.0 1.25 0.9415 0.7523 3173360 SPBio_000588 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4CCCC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N11 compound treatment 27040.0 -71500.0 -0.61 44920.0 -91700.0 -0.76 -0.9668 -0.9941 2060466 SPBio_000589 OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N12 compound treatment 106120.0 7560.0 0.06 171120.0 34500.0 0.29 0.2476 0.8452 2060311 SPBio_000590 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4CC(=O)CC[C@]4(C)C3C=C[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N13 compound treatment 12040.0 -86500.0 -0.74 21520.0 -115000.0 -0.95 -1.194 -0.992 3172984 SPBio_000591 COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CC=C5C(=C(O)C(=O)C=C5[C@]4(C)CC[C@@]3(C)[C@@H]2C1)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N14 compound treatment 29880.0 -68700.0 -0.58 86560.0 -50000.0 -0.41 -0.7061 -0.9857 2060399 SPBio_000592 CC(C)CCCC(C)[C@H]1CCC2C3C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N15 compound treatment 101920.0 3360.0 0.03 289400.0 153000.0 1.26 0.9142 0.7229 911 SPBio_000593 CCCCCC(C)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N16 compound treatment 7840.0 -90700.0 -0.77 20680.0 -116000.0 -0.96 -1.2242 -0.9943 2060079 SPBio_000594 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N17 compound treatment 73400.0 -25200.0 -0.21 276880.0 140000.0 1.16 0.6692 0.567 1001451 SPBio_000595 Cc1cc(C)cc(OCC2CNC(=O)O2)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N18 compound treatment 60720.0 -37800.0 -0.32 213920.0 77300.0 0.64 0.2246 0.3135 1600 SPBio_000596 CCCCC[C@H](CC(=O)NO)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N19 compound treatment 107240.0 8680.0 0.07 251840.0 115000.0 0.95 0.7265 0.7596 1470 SPBio_000597 N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCNC(=N)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N20 compound treatment 65560.0 -33000.0 -0.28 104320.0 -32300.0 -0.27 -0.3874 -0.9997 2060071 SPBio_000598 CCOC(=O)c1c(C)cc(O)c(C=O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N21 compound treatment 77520.0 -21000.0 -0.18 155520.0 18900.0 0.16 -0.0159 -0.0667 399 SPBio_000599 Nc1nc2ccc(OC(F)(F)F)cc2s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N22 compound treatment 7400.0 -91200.0 -0.78 14600.0 -122000.0 -1.01 -1.2624 -0.9916 3172726 SPBio_000600 C[C@]12C3CCC(O3)[C@]2(C)C(=O)OC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N23 mock treatment 91840.0 -6720.0 -0.06 187960.0 51400.0 0.43 0.2601 0.6065 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 N24 mock treatment 56800.0 -41800.0 -0.36 186160.0 49600.0 0.41 0.0386 0.0711 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O01 mock treatment 79080.0 -19500.0 -0.17 114800.0 -21800.0 -0.18 -0.2447 -0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O02 mock treatment 89600.0 -8960.0 -0.08 198960.0 62400.0 0.52 0.311 0.5961 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O03 compound treatment 73000.0 -25600.0 -0.22 155680.0 19100.0 0.16 -0.0422 -0.1568 2060228 SPBio_000601 COC(=O)CC1[C@@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C=C4[C@]53O[C@]2(O)[C@@H]([C@H]5OC(=O)C)C(OC(=O)C)C1(C)C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O04 compound treatment 72680.0 -25900.0 -0.22 233920.0 97300.0 0.81 0.4136 0.4954 1129781 SPBio_000602 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(OC)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O05 compound treatment 20800.0 -77800.0 -0.66 30200.0 -106000.0 -0.88 -1.0904 -0.9902 2060178 SPBio_000603 CC12C[C@@H](O)C3C(CCC4CC(O)CCC43C)C2(O)CCC1C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O06 compound treatment 50360.0 -48200.0 -0.41 266840.0 130000.0 1.08 0.4718 0.4092 2060451 SPBio_000604 CC(C)(O)CC[C@@H](O)[C@](C)(O)C1CC[C@@]2(O)C3=CC(=O)C4C[C@@H](O)[C@@H](O)C[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O07 compound treatment 39920.0 -58600.0 -0.5 229760.0 93200.0 0.77 0.192 0.2091 2060209 SPBio_000605 COc1cc2OCC3Oc4c(C(=O)O)c(O)ccc4C(=O)C3(O)c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O08 compound treatment 45600.0 -53000.0 -0.45 250960.0 114000.0 0.95 0.3502 0.3341 3174226 SPBio_000606 CC[N+](C)(C)Cc1ccc(Br)cc1.Cc1ccc(cc1)S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O09 compound treatment 11360.0 -87200.0 -0.74 131640.0 -4940.0 -0.04 -0.5539 -0.7449 2060130 SPBio_000607 COc1ccc(cc1)[C@@H](C)C(=O)c2ccc(O)cc2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O10 compound treatment 65440.0 -33100.0 -0.28 311440.0 175000.0 1.45 0.8235 0.5587 3263 SPBio_000608 CNC(C)(C)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O11 compound treatment 90880.0 -7680.0 -0.07 262880.0 126000.0 1.04 0.6926 0.6616 2060064 SPBio_000609 CCC(C)C(=O)OC1[C@@H]2CC3=C4CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC3[C@](C)([C@@H](CC(=O)OC)C1(C)C)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O12 compound treatment 204920.0 106000.0 0.91 302800.0 166000.0 1.38 1.6127 0.9795 1231 SPBio_000610 CC(C)C[C@H](NC(=O)C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O13 compound treatment 94600.0 -3960.0 -0.03 169200.0 32600.0 0.27 0.167 0.614 2060078 SPBio_000611 COc1cc2OC[C@H]3Oc4c(CC=C(C)C)c(O)ccc4C(=O)[C@H]3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O14 compound treatment 188400.0 89800.0 0.76 317480.0 181000.0 1.5 1.5991 0.9515 2060471 SPBio_000612 C[C@H]1[C@H]2[C@H](OC1=O)[C@@H]3C(=CC(=O)C3=C(C)C[C@@H]2O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O15 compound treatment 104200.0 5640.0 0.05 165040.0 28500.0 0.24 0.2004 0.8342 1009294 SPBio_000613 Oc1ccc2C(=O)c3ccccc3C(=O)c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O16 compound treatment 6960.0 -91600.0 -0.78 20920.0 -116000.0 -0.96 -1.2281 -0.9949 3055313 SPBio_000614 CC(C)[C@@]12O[C@H]2[C@@H]3O[C@]34[C@]5(O[C@H]5C[C@H]6C7=C(CC[C@@]64C)C(=O)OC7)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O17 compound treatment 52800.0 -45800.0 -0.39 318480.0 182000.0 1.5 0.7886 0.5073 1112402 SPBio_000615 COc1ccc2ccc(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O18 compound treatment 44240.0 -54300.0 -0.46 62520.0 -74100.0 -0.61 -0.7603 -0.9904 2559 SPBio_000616 CC(=O)O[Cd]OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O19 compound treatment 64080.0 -34500.0 -0.29 191680.0 55100.0 0.46 0.1147 0.2116 1016781 SPBio_000617 OC(=O)c1cc(O)c(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O20 compound treatment 76560.0 -22000.0 -0.19 263120.0 127000.0 1.05 0.6078 0.5715 1120 SPBio_000618 Oc1ccc(cc1[N+](=O)[O-])[As](=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O21 compound treatment 83360.0 -15200.0 -0.13 303840.0 167000.0 1.38 0.8869 0.6382 2060044 SPBio_000619 CC(=O)Oc1cc(cc(OC(=O)C)c1OC(=O)C)c2coc3cc(OC(=O)C)c(OC(=O)C)c(OC(=O)C)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O22 compound treatment 30600.0 -68000.0 -0.58 83000.0 -53600.0 -0.44 -0.7226 -0.9913 2060156 SPBio_000620 CCC(C)C(O)C(=O)O[C@H]1[C@H](OC=O)C(C(=C)C2(O)C(=O)C[C@@H](c3ccoc3)[C@]12C)[C@]4(C)C(CC(=O)OC)[C@@](C)(COC(=O)C)OC(=O)C[C@@H]4OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O23 mock treatment 62760.0 -35800.0 -0.3 235880.0 99300.0 0.82 0.3653 0.417 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 O24 mock treatment 89280.0 -9280.0 -0.08 140160.0 3580.0 0.03 -0.0349 -0.414 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P01 mock treatment 78440.0 -20100.0 -0.17 57080.0 -79500.0 -0.66 -0.5862 -0.8625 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P02 mock treatment 83320.0 -15200.0 -0.13 104920.0 -31700.0 -0.26 -0.277 -0.9475 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P03 compound treatment 44680.0 -53900.0 -0.46 91600.0 -45000.0 -0.37 -0.5875 -0.9946 1001332 SPBio_000621 CN(C)CCC[C@]1(OCc2cc(C#N)ccc21)c3ccc(F)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P04 compound treatment 71400.0 -27200.0 -0.23 159720.0 23100.0 0.19 -0.0282 -0.0938 2060433 SPBio_000622 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O[C@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P05 compound treatment 2960.0 -95600.0 -0.81 7520.0 -129000.0 -1.07 -1.3305 -0.991 1228 SPBio_000623 CC[Hg]Sc1ccccc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P06 compound treatment 2920.0 -95600.0 -0.81 8680.0 -128000.0 -1.06 -1.324 -0.9916 336 SPBio_000624 COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P07 compound treatment 7320.0 -91200.0 -0.78 18760.0 -118000.0 -0.97 -1.2385 -0.9937 1210108 SPBio_000625 Oc1ccc2cccc(O)c(=O)c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P08 compound treatment 42600.0 -56000.0 -0.48 256480.0 120000.0 0.99 0.3645 0.3312 1043 SPBio_000626 O[Hg]c1c(O)c(Br)cc2c(c3ccccc3C(=O)O)c4cc(Br)c(=O)cc4oc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P09 compound treatment 42400.0 -56200.0 -0.48 260320.0 124000.0 1.02 0.3857 0.3414 932 SPBio_000627 NCCCCC(N)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CCCCN)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P10 compound treatment 40440.0 -58100.0 -0.49 237920.0 101000.0 0.84 0.2429 0.2495 2060324 SPBio_000628 CC12CC[C@@H]3[C@H](CC3(C)C)C(=C)CC2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P11 compound treatment 51520.0 -47000.0 -0.4 350080.0 213000.0 1.77 0.9657 0.5332 1032444 SPBio_000629 CC(=O)Oc1c(C)cccc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P12 compound treatment 118400.0 19800.0 0.17 296280.0 160000.0 1.32 1.0536 0.7911 2060355 SPBio_000630 CC1=C(C=C)/C(=C/c2[nH]c(Cc3[nH]c(\C=C\4/NC(=O)C(=C4C)C=C)c(C)c3CCC(=O)O)c(CCC(=O)O)c2C)/NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P13 compound treatment 111160.0 12600.0 0.11 272880.0 136000.0 1.13 0.8732 0.7709 1578 SPBio_000631 CC1=NCCc2c1[nH]c3cc(O)ccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P14 compound treatment 56240.0 -42300.0 -0.36 283000.0 146000.0 1.21 0.6017 0.4761 3174615 SPBio_000632 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P15 compound treatment 67640.0 -30900.0 -0.26 267320.0 131000.0 1.08 0.5786 0.5198 3173998 SPBio_000633 CC(=O)O[C@@H]1C2CC[C@@H]3C1(C[C@@]2(C)O)C[C@@H](O)[C@@]4(O)[C@@H](C[C@H](O)C4(C)C)[C@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P16 compound treatment 47800.0 -50800.0 -0.43 279400.0 143000.0 1.18 0.5298 0.4212 3173217 SPBio_000634 CCN1C[C@@]2(COC)C3[C@@H](OC)[C@H]4[C@@H]1[C@@]3(C5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)C5[C@]4(OC(=O)C)[C@@H](O)[C@@H]6OC)C(C[C@H]2O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P17 compound treatment 59760.0 -38800.0 -0.33 321920.0 185000.0 1.53 0.8506 0.5423 2069287 SPBio_000635 CCCCCC1C(CC(=O)OC)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P18 compound treatment 40080.0 -58500.0 -0.5 150520.0 13900.0 0.12 -0.2705 -0.5293 425 SPBio_000636 Oc1ccc(cc1)c2coc3cc(O)cc(O)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P19 compound treatment 55240.0 -43300.0 -0.37 241520.0 105000.0 0.87 0.3531 0.3743 1229 SPBio_000637 CC(=O)N[C@H]1[C@@H](O)C[C@](O)(O[C@@H]1C(O)[C@H](O)CO)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P20 compound treatment 59400.0 -39200.0 -0.33 213760.0 77200.0 0.64 0.2157 0.2995 2060371 SPBio_000638 COC(=O)C[C@H]1C(C)(C)C2(O)OC34CC2C(=O)[C@]1(C)C4CC[C@@]5(C)[C@@H](OC(=O)C=C35)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P21 compound treatment 69520.0 -29000.0 -0.25 117000.0 -19600.0 -0.16 -0.2894 -0.979 2070 SPBio_000639 COc1ccc(cc1)c2coc3cc(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P22 compound treatment 100440.0 1880.0 0.02 143760.0 7180.0 0.06 0.0533 0.8668 1000253 SPBio_000640 NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P23 mock treatment 105920.0 7360.0 0.06 83480.0 -53100.0 -0.44 -0.2663 -0.6002 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2159 P24 mock treatment 68040.0 -30500.0 -0.26 56280.0 -80300.0 -0.66 -0.6535 -0.9161 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A01 mock treatment 67680.0 -31200.0 -0.27 53800.0 -33100.0 -0.27 -0.3814 -0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A02 mock treatment 108200.0 9320.0 0.08 109920.0 23000.0 0.19 0.1908 0.9246 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A03 compound treatment 96240.0 -2650.0 -0.02 92680.0 5790.0 0.05 0.0179 0.339 2060176 SPBio_000641 CC(=O)/C=C\[C@H]1[C@](C)(O)CCC2C(C)(C)CCC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A04 compound treatment 189160.0 90300.0 0.77 187440.0 101000.0 0.83 1.1317 0.9992 3057756 SPBio_000642 C1CCN2C[C@H]3C[C@@H](CN4CCCC[C@H]34)[C@@H]2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A05 compound treatment 212440.0 114000.0 0.97 209600.0 123000.0 1.02 1.4015 0.9997 1016582 SPBio_000643 COc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A06 compound treatment 255920.0 157000.0 1.34 248080.0 161000.0 1.33 1.8883 1.0 1151 SPBio_000644 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A07 compound treatment 246080.0 147000.0 1.25 225160.0 138000.0 1.14 1.695 0.999 3054108 SPBio_000645 Nc1nc2ncc(=O)[nH]c2c(=O)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A08 compound treatment 225440.0 127000.0 1.08 226800.0 140000.0 1.16 1.5804 0.9994 1023016 SPBio_000646 COc1ccc2ccc(=O)oc2c1CC=C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A09 compound treatment 81840.0 -17000.0 -0.15 88800.0 1910.0 0.02 -0.0914 -0.6264 2060374 SPBio_000647 CCC(C)C(OC(=O)C)C(=O)O[C@H]1[C@H](O)C2[C@@]3(C)C=CC(=O)C(C)(C)C3C[C@@H](OC(=O)C(O)C(C)C)[C@@]2(C)[C@]45O[C@@H]5C[C@@H](c6ccoc6)[C@]14C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A10 compound treatment 14000.0 -84900.0 -0.72 14160.0 -72700.0 -0.6 -0.9365 -0.9958 2549 SPBio_000648 C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A11 compound treatment 230360.0 131000.0 1.12 263400.0 177000.0 1.46 1.8241 0.9914 2069225 SPBio_000649 Oc1cc(O)c2C[C@@H](OC(=O)c3cc(O)c(O)c(O)c3)[C@H](Oc2c1)c4cc(O)c(O)c5c(=O)c(O)cc(cc45)[C@H]6Oc7cc(O)cc(O)c7C[C@H]6OC(=O)c8cc(O)c(O)c(O)c8 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A12 compound treatment 262040.0 163000.0 1.39 231480.0 145000.0 1.2 1.8281 0.9972 3059440 SPBio_000650 OC(=O)C1CC(CN2CCCCC12)[C@@H]3CCCCN3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A13 compound treatment 237960.0 139000.0 1.18 238400.0 152000.0 1.25 1.7236 0.9996 2546 SPBio_000651 COC(=O)NC(=S)Nc1ccccc1NC(=S)NC(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A14 compound treatment 291920.0 193000.0 1.64 279320.0 192000.0 1.59 2.2878 0.9999 2060439 SPBio_000652 COC1=C(OC)C(=O)C(=C(C)C1=O)C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC\C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A15 compound treatment 255760.0 157000.0 1.34 252920.0 166000.0 1.37 1.9157 0.9999 3078460 SPBio_000653 CO/N=C(\C(=O)NC1C2SCC(=C(N2C1=O)C(=O)OCOC(=O)C(C)(C)C)/C=C\c3scnc3C)/c4csc(N)n4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A16 compound treatment 227720.0 129000.0 1.1 251440.0 165000.0 1.36 1.7382 0.9943 1307902 SPBio_000654 CN1CCCCC1c2ccc(nc2)c3cccnc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A17 compound treatment 271480.0 173000.0 1.47 271640.0 185000.0 1.53 2.1198 0.9998 2575 SPBio_000655 CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A18 compound treatment 248040.0 149000.0 1.27 252280.0 165000.0 1.37 1.8655 0.9993 3078270 SPBio_000656 CN(C)CCc1c[nH]c2ccc(C[C@H]3COC(=O)N3)cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A19 compound treatment 53080.0 -45800.0 -0.39 48960.0 -37900.0 -0.31 -0.4976 -0.9942 3480341 SPBio_000657 CN1CCCC(CC1)n2nc(Cc3ccc(Cl)cc3)c4ccccc4c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A20 compound treatment 219080.0 120000.0 1.02 208360.0 121000.0 1.0 1.4342 1.0 1204574 SPBio_000658 COc1c(oc2cc3oc(=O)ccc3cc12)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A21 compound treatment 17800.0 -81100.0 -0.69 20480.0 -66400.0 -0.55 -0.8767 -0.9936 1351 SPBio_000659 Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A22 compound treatment 68840.0 -30000.0 -0.26 80680.0 -6210.0 -0.05 -0.2172 -0.8325 1008178 SPBio_000660 COc1cc(C)c(C(=O)Oc2cc(C)c(C(=O)O)c(O)c2C)c(OC)c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A23 mock treatment 86160.0 -12700.0 -0.11 82560.0 -4330.0 -0.04 -0.1019 -0.8933 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 A24 mock treatment 55920.0 -43000.0 -0.37 37000.0 -49900.0 -0.41 -0.5505 -0.9982 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B01 mock treatment 151720.0 52800.0 0.45 139800.0 52900.0 0.44 0.6276 0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B02 mock treatment 187160.0 88300.0 0.75 199080.0 112000.0 0.93 1.1877 0.9945 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B03 compound treatment 202120.0 103000.0 0.88 194040.0 107000.0 0.89 1.2483 1.0 2069255 SPBio_000661 Oc1cc(cc(O)c1O)c2coc3cc(O)c(O)c(O)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B04 compound treatment 118840.0 20000.0 0.17 119040.0 32200.0 0.27 0.3082 0.9766 2060101 SPBio_000662 COc1ccc(cc1OC)[C@H]2Oc3c(I)c(OC)cc(OC)c3C[C@@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B05 compound treatment 208840.0 110000.0 0.94 222120.0 135000.0 1.12 1.453 0.9961 901 SPBio_000663 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B06 compound treatment 149560.0 50700.0 0.43 143600.0 56700.0 0.47 0.6368 0.9991 910 SPBio_000664 CN1CC(CNC(=O)OCc2ccccc2)C[C@@H]3C1Cc4cn(C)c5cccc3c45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B07 compound treatment 262160.0 163000.0 1.39 247640.0 161000.0 1.33 1.9233 0.9998 1315 SPBio_000665 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B08 compound treatment 265800.0 167000.0 1.42 281720.0 195000.0 1.61 2.1446 0.998 683 SPBio_000666 Cc1ncc([N+](=O)[O-])n1CCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B09 compound treatment 114560.0 15700.0 0.13 63960.0 -22900.0 -0.19 -0.0398 -0.1714 2069270 SPBio_000667 CC(C)CCCC(C)C1CCC2C3CC(=O)[C@H]4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B10 compound treatment 309840.0 211000.0 1.8 322080.0 235000.0 1.95 2.6458 0.9992 3059437 SPBio_000668 OC[C@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B11 compound treatment 252720.0 154000.0 1.31 286080.0 199000.0 1.65 2.0914 0.9935 1044412 SPBio_000669 Oc1cc2ccccc2oc1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B12 compound treatment 257400.0 159000.0 1.35 254960.0 168000.0 1.39 1.9375 0.9999 1090 SPBio_000670 CCC[C@@H]1C[C@H](N(C)C1)C(=O)NC(C(C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B13 compound treatment 140520.0 41600.0 0.35 144800.0 57900.0 0.48 0.5894 0.989 3198326 SPBio_000671 O[C@@H]1O[C@H](COC(=O)CC[N+](=O)[O-])[C@@H](OC(=O)CC[N+](=O)[O-])[C@H](OC(=O)CC[N+](=O)[O-])[C@H]1OC(=O)CC[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B14 compound treatment 131880.0 33000.0 0.28 153480.0 66600.0 0.55 0.5882 0.9512 1259 SPBio_000672 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B15 compound treatment 154840.0 56000.0 0.48 159600.0 72700.0 0.6 0.7622 0.9933 3177521 SPBio_000673 COc1cc(cc(OC)c1OC)[C@H]2[C@H]3[C@H](COC3=O)[C@@H](OC(=O)C)c4cc5OCOc5cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B16 compound treatment 23280.0 -75600.0 -0.64 23040.0 -63900.0 -0.53 -0.8287 -0.9952 2551 SPBio_000674 COc1cc(NC(C)CCCN)c2ncccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B17 compound treatment 248320.0 149000.0 1.27 241360.0 154000.0 1.28 1.8033 1.0 1050602 SPBio_000675 COc1ccc(CC(=O)c2ccc(O)cc2O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B18 compound treatment 15760.0 -83100.0 -0.71 15280.0 -71600.0 -0.59 -0.9194 -0.9961 763 SPBio_000676 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B19 compound treatment 186280.0 87400.0 0.74 152800.0 65900.0 0.55 0.9117 0.9883 2069259 SPBio_000677 C[C@@]12CCC3C(CC[C@H]4C[C@H](O)CC[C@@]43C)C2CC[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B20 compound treatment 12840.0 -86000.0 -0.73 11880.0 -75000.0 -0.62 -0.9568 -0.9966 368 SPBio_000678 CC/C(=C(\c1ccccc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B21 compound treatment 232600.0 134000.0 1.14 212040.0 125000.0 1.04 1.5371 0.9989 3172708 SPBio_000679 CCC(C)C(=O)O[C@H]1[C@H](O)C2C(CN3CC(C)CCC3[C@@]2(C)O)C4C[C@]5(O[C@@]6(O)C7C(OC(=O)C)[C@@H](OC(=O)C)C5[C@@]41O)[C@@]7(C)CCC6OC(=O)C(C)(O)C(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B22 compound treatment 112720.0 13800.0 0.12 105760.0 18900.0 0.16 0.1937 0.9904 3198420 SPBio_000680 CC[C@]1(O)CC2CN(C1)CCc3c([nH]c4ccccc34)[C@@](C2)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@H]7[C@@]86CCN9CC=C[C@](CC)([C@H]98)[C@@H](OC(=O)C)[C@]7(O)C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B23 mock treatment 211360.0 112000.0 0.96 198120.0 111000.0 0.92 1.3278 0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 B24 mock treatment 91160.0 -7730.0 -0.07 19920.0 -67000.0 -0.55 -0.4383 -0.7855 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C01 mock treatment 133880.0 35000.0 0.3 117560.0 30700.0 0.25 0.3901 0.9968 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C02 mock treatment 184320.0 85400.0 0.73 197680.0 111000.0 0.92 1.1624 0.9934 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C03 compound treatment 198680.0 99800.0 0.85 160120.0 73200.0 0.61 1.0292 0.9863 2060254 SPBio_000681 CC(=O)CC1CCCCN1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C04 compound treatment 116360.0 17500.0 0.15 115280.0 28400.0 0.23 0.2713 0.9757 2060501 SPBio_000682 CC(C)(OC(=O)c1ccccc1)[C@@H]2Cc3cc4ccc(=O)oc4cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C05 compound treatment 228200.0 129000.0 1.1 226080.0 139000.0 1.15 1.5928 0.9997 2060245 SPBio_000683 OC[C@H]1O[C@@](CO)(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C06 compound treatment 253080.0 154000.0 1.31 259520.0 173000.0 1.43 1.9382 0.9991 3177461 SPBio_000684 CN1C2C[C@H](O)[C@@H]1C[C@H](C2)OC(=O)[C@H](CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C07 compound treatment 241360.0 142000.0 1.21 220040.0 133000.0 1.1 1.6367 0.9988 2069293 SPBio_000685 CCc1ccc2c(O)c3C(=O)c4c(O)ccc(O)c4C(=O)c3cc2c1C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C08 compound treatment 262840.0 164000.0 1.4 274520.0 188000.0 1.55 2.0847 0.9986 1296906 SPBio_000686 COc1ccc(C(=O)CC(=O)O)c2OC(C)(C)C=Cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C09 compound treatment 27720.0 -71200.0 -0.61 36600.0 -50300.0 -0.42 -0.7226 -0.9832 1092958 SPBio_000687 COC1=CC(=O)C(=CC1=O)C(C=C)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C10 compound treatment 116960.0 18100.0 0.15 132160.0 45300.0 0.37 0.3736 0.9228 1253 SPBio_000688 C[C@H]1OC=C2C(=C(C(=O)O)C(=O)C(=C2[C@@H]1C)C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C11 compound treatment 270840.0 172000.0 1.46 271280.0 184000.0 1.53 2.1139 0.9998 1262 SPBio_000689 NC[C@H]1CC[C@@H](CC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C12 compound treatment 274680.0 176000.0 1.5 260400.0 174000.0 1.44 2.0734 0.9998 1216977 SPBio_000690 CC1(C)Oc2ccc3ccc(=O)oc3c2CC1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C13 compound treatment 276800.0 178000.0 1.51 281720.0 195000.0 1.61 2.2108 0.9995 1000143 SPBio_000691 NC(Cn1ccc(=O)c(O)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C14 compound treatment 262560.0 164000.0 1.39 247840.0 161000.0 1.33 1.9269 0.9997 2321 SPBio_000692 COc1ccc2CC3N(CCc4cc(OC)c(OC)cc34)Cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C15 compound treatment 265240.0 166000.0 1.42 265400.0 179000.0 1.48 2.0458 0.9998 3172716 SPBio_000693 NC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C16 compound treatment 269920.0 171000.0 1.46 265240.0 178000.0 1.48 2.073 1.0 3055383 SPBio_000694 CC(C)(O)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C17 compound treatment 245120.0 146000.0 1.25 236880.0 150000.0 1.24 1.7578 1.0 3078461 SPBio_000695 NCCc1ccccc1S(=O)(=O)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C18 compound treatment 222440.0 124000.0 1.05 226440.0 140000.0 1.15 1.5602 0.9989 1501 SPBio_000696 NCCc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C19 compound treatment 55920.0 -43000.0 -0.37 67200.0 -19700.0 -0.16 -0.3739 -0.9336 3198318 SPBio_000697 C[C@H]1CCCC(=O)CCC/C=C/c2cc(O)cc(O)c2C(=O)O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C20 compound treatment 238880.0 140000.0 1.19 233360.0 146000.0 1.21 1.6996 1.0 1368 SPBio_000698 CCC(C)C(N)C1=NC(CS1)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NCCCCC2NC(=O)C(CC(=O)N)NC(=O)C(CC(=O)O)NC(=O)C(Cc3c[nH]cn3)NC(=O)C(Cc4ccccc4)NC(=O)C(NC(=O)C(CCCN)NC2=O)C(C)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C21 compound treatment 209400.0 111000.0 0.94 190440.0 104000.0 0.86 1.2711 0.9989 2141061 SPBio_000699 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(C[C@@H](O)[C@@H](O)[C@@H](O)CO)c2cc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C22 compound treatment 155760.0 56900.0 0.48 150280.0 63400.0 0.52 0.7132 0.9992 2060491 SPBio_000700 CC(C)CC(=O)O[C@@H]1[C@H](OC(=O)C)c2c(OC1(C)C)ccc3ccc(=O)oc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C23 mock treatment 187520.0 88600.0 0.75 135240.0 48400.0 0.4 0.8165 0.9559 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 C24 mock treatment 47480.0 -51400.0 -0.44 28160.0 -58700.0 -0.49 -0.653 -0.9986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D01 mock treatment 131760.0 32900.0 0.28 125880.0 39000.0 0.32 0.426 0.9975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D02 mock treatment 140360.0 41500.0 0.35 102000.0 15100.0 0.13 0.3381 0.9025 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D03 compound treatment 123920.0 25000.0 0.21 95840.0 8950.0 0.07 0.2031 0.9 2060503 SPBio_000701 C1Oc2ccc(cc2O1)[C@H]3OC[C@@H]4[C@@H](OC[C@H]34)c5ccc6OCOc6c5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D04 compound treatment 12120.0 -86800.0 -0.74 11200.0 -75700.0 -0.63 -0.9651 -0.9966 1070 SPBio_000702 CCC(C(CC)c1ccc(O)cc1)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D05 compound treatment 18000.0 -80900.0 -0.69 17640.0 -69300.0 -0.57 -0.8921 -0.9958 2060397 SPBio_000703 COc1ccc2C(=O)/C(=C/c3ccc(OC)c(O)c3)/COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D06 compound treatment 140520.0 41600.0 0.35 134720.0 47800.0 0.4 0.5305 0.9985 804 SPBio_000704 COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D07 compound treatment 271320.0 172000.0 1.47 261120.0 174000.0 1.44 2.0573 1.0 2069258 SPBio_000705 COc1ccc(c(OC)c1O)c2coc3cc(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D08 compound treatment 86120.0 -12800.0 -0.11 82240.0 -4650.0 -0.04 -0.1041 -0.9025 1091345 SPBio_000706 Nc1nc(N)c2nc(CNc3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)cnc2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D09 compound treatment 240520.0 142000.0 1.21 260560.0 174000.0 1.44 1.8686 0.9962 1022 SPBio_000707 COc1cc(OC)c2ccc(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D10 compound treatment 165760.0 66900.0 0.57 169160.0 82300.0 0.68 0.8839 0.9961 909 SPBio_000708 COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D11 compound treatment 257400.0 159000.0 1.35 275600.0 189000.0 1.56 2.0582 0.9974 2060379 SPBio_000709 COc1ccc(cc1)c2coc3c(OC)c(OC)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D12 compound treatment 114320.0 15400.0 0.13 145840.0 59000.0 0.49 0.4378 0.8667 599 SPBio_000710 Cc1cc(O)c2C(=O)c3c(O)cc(O)cc3C(=O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D13 compound treatment 28000.0 -70900.0 -0.6 36680.0 -50200.0 -0.42 -0.7205 -0.9834 3173357 SPBio_000711 CC(=C)[C@@H]1CC[C@@]2(CCC3[C@H](CCC4[C@@]3(C)CCC5C(C)(C)[C@H](O)CC[C@@]54C)C12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D14 compound treatment 257120.0 158000.0 1.35 276840.0 190000.0 1.57 2.0638 0.9971 3173213 SPBio_000712 COc1ccc(C[C@H](N)C(=O)N[C@H]2[C@@H](O)C(O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D15 compound treatment 275800.0 177000.0 1.51 274840.0 188000.0 1.55 2.1646 0.9999 2069325 SPBio_000713 OC(=O)/C=C/C=C/c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D16 compound treatment 214360.0 115000.0 0.98 216760.0 130000.0 1.07 1.4549 0.999 3078281 SPBio_000714 C[C@H]1OC(C(O)[C@@H]1O)n2cc(F)c(=O)[nH]c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D17 compound treatment 264360.0 165000.0 1.41 283280.0 196000.0 1.62 2.1451 0.9975 3173762 SPBio_000715 CC1OC(O[C@@H]/2CC3O[C@@](O)(C[C@H](O)C3C(=O)O)CC(O)CC(O)C(O)CCC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C2)C(O)[C@H](N)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D18 compound treatment 210000.0 111000.0 0.95 211520.0 125000.0 1.03 1.398 0.9991 1477 SPBio_000716 O=C1O[Pt]OC(=O)C21CCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D19 compound treatment 28560.0 -70300.0 -0.6 72760.0 -14100.0 -0.12 -0.506 -0.8295 1907763 SPBio_000717 Oc1ccc(/C=C/C(=O)OCCc2ccccc2)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D20 compound treatment 238000.0 139000.0 1.18 226120.0 139000.0 1.15 1.652 0.9999 1475 SPBio_000718 Cl[Pt]Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D21 compound treatment 73080.0 -25800.0 -0.22 95040.0 8150.0 0.07 -0.1077 -0.4686 1913676 SPBio_000719 COc1ccc(cc1)C(=O)/C=C/c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D22 compound treatment 54200.0 -44700.0 -0.38 45240.0 -41700.0 -0.34 -0.5127 -0.9988 2080598 SPBio_000720 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC2CC(=O)NC(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D23 mock treatment 180120.0 81200.0 0.69 131800.0 44900.0 0.37 0.7518 0.9575 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 D24 mock treatment 52480.0 -46400.0 -0.4 29520.0 -57400.0 -0.47 -0.615 -0.9958 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E01 mock treatment 179640.0 80800.0 0.69 160720.0 73800.0 0.61 0.9181 0.9983 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E02 mock treatment 142880.0 44000.0 0.37 97920.0 11000.0 0.09 0.3294 0.8544 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E03 compound treatment 197480.0 98600.0 0.84 169520.0 82600.0 0.68 1.077 0.9948 2060173 SPBio_000721 CC(C)C1CCC(C)(O)C2CCC(=CC12)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E04 compound treatment 113840.0 15000.0 0.13 118960.0 32100.0 0.27 0.2776 0.9434 2060454 SPBio_000722 Oc1cc(O)c2c(=O)cc(oc2c1)c3cc(O)c(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E05 compound treatment 242280.0 143000.0 1.22 232440.0 146000.0 1.2 1.7147 1.0 3174242 SPBio_000723 OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E06 compound treatment 234640.0 136000.0 1.16 235040.0 148000.0 1.23 1.6839 0.9996 1482 SPBio_000724 CN1CCc2cc3OCOc3cc2C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E07 compound treatment 251040.0 152000.0 1.3 241840.0 155000.0 1.28 1.8225 1.0 1000946 SPBio_000725 COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E08 compound treatment 300800.0 202000.0 1.72 379200.0 292000.0 2.42 2.9256 0.986 1398 SPBio_000726 CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(OC(=O)C)c(C)c(C)c2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E09 compound treatment 267760.0 169000.0 1.44 299720.0 213000.0 1.76 2.2617 0.9949 3078462 SPBio_000727 [Na+].[O-]C(=O)CF 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E10 compound treatment 33160.0 -65700.0 -0.56 37360.0 -49500.0 -0.41 -0.6854 -0.9883 1588 SPBio_000728 CC(=O)C1C(=O)C=C2Oc3c(c(O)c(C)c(O)c3C(=O)C)C2(C)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E11 compound treatment 245200.0 146000.0 1.25 232400.0 146000.0 1.2 1.7321 0.9999 465 SPBio_000729 NCCc1c[nH]cn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E12 compound treatment 312160.0 213000.0 1.82 319080.0 232000.0 1.92 2.6423 0.9996 2060490 SPBio_000730 C/C=C(\C)/C(=O)O[C@H]1[C@@H](OC(=O)C)C(C)(C)Oc2ccc3ccc(=O)oc3c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E13 compound treatment 283200.0 184000.0 1.57 298880.0 212000.0 1.75 2.3497 0.9985 1000060 SPBio_000731 COC(=O)C1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E14 compound treatment 167880.0 69000.0 0.59 210760.0 124000.0 1.02 1.14 0.9651 1000136 SPBio_000732 CC12CCC3C(=CCc4cc(O)ccc34)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E15 compound treatment 256560.0 158000.0 1.34 241920.0 155000.0 1.28 1.8562 0.9997 1243 SPBio_000733 OC[C@H]1OC(C[C@H]1O)n2cc(F)c(=O)[nH]c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E16 compound treatment 229000.0 130000.0 1.11 416160.0 329000.0 2.72 2.7095 0.9214 2060357 SPBio_000734 CC(=O)O[C@@H]1CC2C(C)(C)CCC(=O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E17 compound treatment 262320.0 163000.0 1.39 278120.0 191000.0 1.58 2.1026 0.998 1498 SPBio_000735 OC(=O)P(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E18 compound treatment 232400.0 134000.0 1.14 229920.0 143000.0 1.18 1.6405 0.9998 3078271 SPBio_000736 COC(=O)C[C@H]1C(C)(C)[C@H](O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CC[C@H](C3=C)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E19 compound treatment 159360.0 60500.0 0.51 156400.0 69500.0 0.58 0.7707 0.9985 3198319 SPBio_000737 O=C1O[C@]2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E20 compound treatment 186960.0 88100.0 0.75 184080.0 97200.0 0.8 1.0988 0.9994 2060049 SPBio_000738 Cc1cc(=O)c2c(O)c(C)c(O)cc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E21 compound treatment 240200.0 141000.0 1.2 221120.0 134000.0 1.11 1.636 0.9992 1290 SPBio_000739 OC(=O)c1ccc(cc1)S(=O)(=O)N(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E22 compound treatment 176240.0 77400.0 0.66 170840.0 84000.0 0.69 0.9568 0.9996 2060435 SPBio_000740 COC(=O)C(OC(=O)C)[C@H]1C(C)(C)C(=O)C[C@@H]2O[C@@]34CC(=O)O[C@@H](c5ccoc5)[C@]4(C)CCC(C3=C)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E23 mock treatment 164880.0 66000.0 0.56 148920.0 62000.0 0.51 0.7602 0.999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 E24 mock treatment 74680.0 -24200.0 -0.21 40040.0 -46900.0 -0.39 -0.4198 -0.9563 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F01 mock treatment 198280.0 99400.0 0.85 181520.0 94600.0 0.78 1.152 0.9992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F02 mock treatment 152680.0 53800.0 0.46 126000.0 39100.0 0.32 0.5527 0.9855 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F03 compound treatment 90000.0 -8890.0 -0.08 78640.0 -8250.0 -0.07 -0.1018 -0.9987 2060314 SPBio_000741 COC(=O)c1c(C)c2Oc3c(Cl)c(OC)c(Cl)c(C)c3C(=O)Oc2c(C)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F04 compound treatment 95400.0 -3490.0 -0.03 83400.0 -3490.0 -0.03 -0.0414 -0.9999 1000048 SPBio_000742 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F05 compound treatment 135160.0 36300.0 0.31 130600.0 43700.0 0.36 0.4741 0.9969 401 SPBio_000743 COc1cccc2c1cc([N+](=O)[O-])c3c(cc4OCOc4c23)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F06 compound treatment 242440.0 144000.0 1.22 232320.0 145000.0 1.2 1.715 1.0 1537 SPBio_000744 NC(Cc1ccc(F)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F07 compound treatment 91600.0 -7290.0 -0.06 92840.0 5950.0 0.05 -0.0091 -0.1143 2060376 SPBio_000745 CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(=O)C)c3C(=O)c12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F08 compound treatment 22280.0 -76600.0 -0.65 24200.0 -62700.0 -0.52 -0.8279 -0.9936 383 SPBio_000746 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccccc5cc4Cn3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F09 compound treatment 255840.0 157000.0 1.34 279080.0 192000.0 1.59 2.0692 0.9963 1334 SPBio_000747 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F10 compound treatment 272520.0 174000.0 1.48 313080.0 226000.0 1.87 2.3685 0.9932 767 SPBio_000748 OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC(C#N)c3ccccc3)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F11 compound treatment 296440.0 198000.0 1.68 282120.0 195000.0 1.62 2.3314 0.9998 1314 SPBio_000749 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2Cc3ccccc3C[C@H]2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F12 compound treatment 295800.0 197000.0 1.68 283800.0 197000.0 1.63 2.3374 0.9999 598 SPBio_000750 Oc1cc2c(=O)oc3c(O)c(O)cc4c(=O)oc(c1O)c2c43 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F13 compound treatment 96800.0 -2090.0 -0.02 102320.0 15400.0 0.13 0.0777 0.603 2060316 SPBio_000751 COc1c2C=CC(C)(C)Oc2cc3occ(c4ccc5OCOc5c4)c(=O)c13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F14 compound treatment 288720.0 190000.0 1.62 269440.0 183000.0 1.51 2.2108 0.9994 1539 SPBio_000752 C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)[C@H]23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F15 compound treatment 256360.0 157000.0 1.34 327440.0 241000.0 1.99 2.3552 0.9815 960 SPBio_000753 C1N2CN3CN1CN(C2)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F16 compound treatment 347080.0 248000.0 2.11 362280.0 275000.0 2.28 3.1052 0.9993 1371 SPBio_000754 CN(C)c1nc(nc(n1)N(C)C)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F17 compound treatment 23080.0 -75800.0 -0.65 31040.0 -55900.0 -0.46 -0.7831 -0.9866 437 SPBio_000755 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F18 compound treatment 16200.0 -82700.0 -0.7 14880.0 -72000.0 -0.6 -0.919 -0.9965 1135 SPBio_000756 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F19 compound treatment 343080.0 244000.0 2.08 223800.0 137000.0 1.13 2.2711 0.9592 1005 SPBio_000757 OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F20 compound treatment 267960.0 169000.0 1.44 295560.0 209000.0 1.73 2.2386 0.9959 726 SPBio_000758 CCOC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F21 compound treatment 234800.0 136000.0 1.16 236440.0 150000.0 1.24 1.6931 0.9994 3078274 SPBio_000759 N[C@H](CO)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F22 compound treatment 208920.0 110000.0 0.94 202600.0 116000.0 0.96 1.3393 0.9999 946 SPBio_000760 OCCNC(=O)Cn1ccnc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F23 mock treatment 184040.0 85200.0 0.73 141960.0 55100.0 0.46 0.8348 0.9749 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 F24 mock treatment 74320.0 -24600.0 -0.21 27680.0 -59200.0 -0.49 -0.4943 -0.928 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G01 mock treatment 112480.0 13600.0 0.12 107520.0 20600.0 0.17 0.2025 0.9821 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G02 mock treatment 134600.0 35700.0 0.3 111800.0 24900.0 0.21 0.3607 0.982 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G03 compound treatment 167360.0 68500.0 0.58 150920.0 64000.0 0.53 0.7868 0.9989 1107153 SPBio_000761 CC(=O)c1cc2C=CC(C)(C)Oc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G04 compound treatment 188200.0 89300.0 0.76 194080.0 107000.0 0.89 1.1648 0.9971 2069251 SPBio_000762 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C[C@H](O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)[C@H]5O[C@]54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G05 compound treatment 241360.0 142000.0 1.21 224400.0 138000.0 1.14 1.6622 0.9995 1984013 SPBio_000763 C/C=C/c1ccc2OCOc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G06 compound treatment 240800.0 142000.0 1.21 257160.0 170000.0 1.41 1.8504 0.9971 3078272 SPBio_000764 [Na+].[O-]S(=O)(=O)CCS 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G07 compound treatment 211160.0 112000.0 0.96 201080.0 114000.0 0.94 1.3439 1.0 2561 SPBio_000765 Oc1ccc(cc1[N+](=O)[O-])[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G08 compound treatment 173280.0 74400.0 0.63 200120.0 113000.0 0.94 1.1103 0.9818 1225 SPBio_000766 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G09 compound treatment 192760.0 93900.0 0.8 196200.0 109000.0 0.9 1.2046 0.9981 2069276 SPBio_000767 COc1cc(cc(OCc2ccccc2)c1OC)c3coc4cc(OCc5ccccc5)c(OC)c(O)c4c3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G10 compound treatment 266920.0 168000.0 1.43 259400.0 173000.0 1.43 2.0208 1.0 2060402 SPBio_000768 COc1ccc2CC[C@H]3CC(=O)CC[C@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G11 compound treatment 294600.0 196000.0 1.67 270120.0 183000.0 1.52 2.2501 0.9989 1001923 SPBio_000769 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G12 compound treatment 112200.0 13300.0 0.11 116600.0 29700.0 0.25 0.254 0.9383 2069256 SPBio_000770 COc1cc2OCOc2cc1/C=C/C(=O)c3cc(OC)c(OC)cc3OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G13 compound treatment 297520.0 199000.0 1.69 295280.0 208000.0 1.72 2.4149 1.0 1189 SPBio_000771 CO[C@]1(NC(=O)Cc2cccs2)[C@H]3SCC(=C(N3C1=O)C(=O)O)COC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G14 compound treatment 242600.0 144000.0 1.22 290080.0 203000.0 1.68 2.0538 0.9878 703 SPBio_000772 OC[C@H]1O[C@@H](Oc2ccccc2CO)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G15 compound treatment 235160.0 136000.0 1.16 265440.0 179000.0 1.48 1.8649 0.9929 866 SPBio_000773 Cc1c(cc(cc1[N+](=O)[O-])[N+](=O)[O-])C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G16 compound treatment 201320.0 102000.0 0.87 224000.0 137000.0 1.13 1.4188 0.9916 976 SPBio_000774 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G17 compound treatment 109120.0 10200.0 0.09 111520.0 24600.0 0.2 0.2057 0.9282 1105 SPBio_000775 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G18 compound treatment 152640.0 53800.0 0.46 147160.0 60300.0 0.5 0.6762 0.9991 2060370 SPBio_000776 COc1cc2OCOc2cc1c3coc4c5C=CC(C)(C)Oc5c(OC)cc4c3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G19 compound treatment 77640.0 -21200.0 -0.18 78920.0 -7970.0 -0.07 -0.1745 -0.9065 2097 SPBio_000777 CCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G20 compound treatment 235960.0 137000.0 1.17 230000.0 143000.0 1.18 1.6624 1.0 935 SPBio_000778 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G21 compound treatment 189600.0 90700.0 0.77 184680.0 97800.0 0.81 1.1182 0.9997 3174101 SPBio_000779 CN1CCc2c(C1)c3ccccc3n2Cc4ccccc4.OS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G22 compound treatment 113840.0 15000.0 0.13 125880.0 39000.0 0.32 0.3181 0.9174 2060092 SPBio_000780 CC(=O)O[C@H]1CC[C@@]2(C)[C@@H](CCC3C4CC=C(C(=O)C)[C@@]4(C)C(=O)CC32)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G23 mock treatment 186280.0 87400.0 0.74 133760.0 46900.0 0.39 0.8003 0.9538 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 G24 mock treatment 33960.0 -64900.0 -0.55 25920.0 -61000.0 -0.5 -0.7475 -0.999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H01 mock treatment 78680.0 -20200.0 -0.17 52040.0 -34900.0 -0.29 -0.3255 -0.9696 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H02 mock treatment 120440.0 21600.0 0.18 100640.0 13800.0 0.11 0.2102 0.9735 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H03 compound treatment 175880.0 77000.0 0.66 146960.0 60100.0 0.5 0.8149 0.9907 3078275 SPBio_000781 C[C@@H](N)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H04 compound treatment 202520.0 104000.0 0.88 177120.0 90200.0 0.75 1.1518 0.9965 695 SPBio_000782 CC1CCC(CC1)NC(=O)N(CCCl)N=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H05 compound treatment 120320.0 21400.0 0.18 130200.0 43300.0 0.36 0.3824 0.951 1000069 SPBio_000783 COc1ccc2C[C@H]3N(C)CCc4cc(OC)c(Oc5c6OCOc6cc7CCN(C)[C@@H](Cc8ccc(Oc1c2)cc8)c75)cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H06 compound treatment 248840.0 150000.0 1.28 226920.0 140000.0 1.16 1.7219 0.9988 1394 SPBio_000784 BrCCC(=O)N1CCN(CC1)C(=O)CCBr 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H07 compound treatment 234480.0 136000.0 1.15 229000.0 142000.0 1.18 1.6477 1.0 3078276 SPBio_000785 COC(=O)N/N=C/c1c[n+]([O-])c2ccccc2[n+]1[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H08 compound treatment 190040.0 91200.0 0.78 150720.0 63800.0 0.53 0.9222 0.9824 3198421 SPBio_000786 CCC(C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)C12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H09 compound treatment 265800.0 167000.0 1.42 238240.0 151000.0 1.25 1.8903 0.998 3078277 SPBio_000787 CN[C@H]1[C@@H](O)[C@H]2O[C@@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H10 compound treatment 284600.0 186000.0 1.58 258680.0 172000.0 1.42 2.123 0.9986 1211 SPBio_000788 CON 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H11 compound treatment 287960.0 189000.0 1.61 269200.0 182000.0 1.51 2.2048 0.9995 1001954 SPBio_000789 C/C=C/1\[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(=C2)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H12 compound treatment 230760.0 132000.0 1.12 244920.0 158000.0 1.31 1.7184 0.9971 2554 SPBio_000790 C[C@H]1[C@H]2CCC3C4CC=C5C[C@H](CC[C@]5(C)C4CC[C@]23CN1C)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H13 compound treatment 332880.0 234000.0 1.99 337560.0 251000.0 2.07 2.8751 0.9998 3198419 SPBio_000791 COc1ccc2cc3c4cc(OC)c(OC)cc4cc[n+]3cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H14 compound treatment 23400.0 -75500.0 -0.64 24120.0 -62800.0 -0.52 -0.8216 -0.9944 1307 SPBio_000792 ClC(Cl)C(c1ccc(Cl)cc1)c2ccccc2Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H15 compound treatment 232640.0 134000.0 1.14 259920.0 173000.0 1.43 1.8174 0.9936 1017172 SPBio_000793 C=CCSCC=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H16 compound treatment 241600.0 143000.0 1.22 237440.0 151000.0 1.25 1.7399 0.9999 2557 SPBio_000794 COS(=O)(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H17 compound treatment 233840.0 135000.0 1.15 255480.0 169000.0 1.39 1.7987 0.9954 1117560 SPBio_000795 CC(=C)C1CCC(=CC1)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H18 compound treatment 223320.0 124000.0 1.06 194800.0 108000.0 0.89 1.3804 0.9964 3198422 SPBio_000796 CN[C@H]1C[C@@H](N)[C@H](O)[C@@H](O[C@@H]2O[C@H](CO)[C@@H]3OC4(O[C@@H]3[C@@H]2O)O[C@H](C(N)CO)[C@H](O)[C@H](O)[C@H]4O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H19 compound treatment 171240.0 72400.0 0.62 176560.0 89700.0 0.74 0.9602 0.9957 1047 SPBio_000797 CN(C)CCCN1c2ccccc2Sc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H20 compound treatment 236320.0 137000.0 1.17 195320.0 108000.0 0.9 1.4617 0.9914 417 SPBio_000798 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H21 compound treatment 125720.0 26800.0 0.23 127120.0 40200.0 0.33 0.3969 0.9832 681 SPBio_000799 CC(CN1c2ccccc2Sc3ccccc13)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H22 compound treatment 12160.0 -86700.0 -0.74 12120.0 -74800.0 -0.62 -0.9595 -0.9961 3046992 SPBio_000800 CO[C@]12[C@@H]3NC3CN2C4=C([C@@H]1COC(=O)N)C(=O)C(=C(C)C4=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H23 mock treatment 152480.0 53600.0 0.46 141680.0 54800.0 0.45 0.6432 1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 H24 mock treatment 17440.0 -81400.0 -0.69 23480.0 -63400.0 -0.52 -0.8613 -0.9905 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I01 mock treatment 51480.0 -47400.0 -0.4 46160.0 -40700.0 -0.34 -0.5237 -0.996 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I02 mock treatment 121800.0 22900.0 0.2 107520.0 20600.0 0.17 0.2586 0.9978 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I03 compound treatment 14360.0 -84500.0 -0.72 12160.0 -74700.0 -0.62 -0.946 -0.9971 647 SPBio_000801 Oc1ccc(CCC(=O)c2c(O)cc(O)cc2O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I04 compound treatment 202360.0 103000.0 0.88 184800.0 97900.0 0.81 1.1957 0.9991 2060425 SPBio_000802 COC(=O)[C@@H]1OC(=O)[C@H]2O[C@@]23[C@@]1(C)CCC4[C@@]5(C)CCC(=O)C(C)(C)C5C[C@@H](OC(=O)C)[C@]43C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I05 compound treatment 238720.0 140000.0 1.19 245880.0 159000.0 1.32 1.7719 0.9988 3174492 SPBio_000803 CN1[C@H]2CC3CC1C(O)C2O3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I06 compound treatment 33360.0 -65500.0 -0.56 29600.0 -57300.0 -0.47 -0.7296 -0.9967 1028 SPBio_000804 Oc1ccc(cc1)C(=C2C=CC(=O)C=C2)c3ccc(O)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I07 compound treatment 241520.0 143000.0 1.21 209880.0 123000.0 1.02 1.5782 0.9961 1029487 SPBio_000805 OCC(O)Cc1ccc2OCOc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I08 compound treatment 166040.0 67200.0 0.57 144080.0 57200.0 0.47 0.7389 0.9956 3198323 SPBio_000806 COc1cc(OC)c2c(=O)c(coc2c1)c3ccc4OCOc4c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I09 compound treatment 133200.0 34300.0 0.29 152680.0 65800.0 0.54 0.5914 0.9575 3078463 SPBio_000807 CCOC(=O)c1c(C)cc(OC)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I10 compound treatment 229640.0 131000.0 1.11 218520.0 132000.0 1.09 1.5572 0.9999 986 SPBio_000808 CN1CC(=O)NC1=N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I11 compound treatment 243720.0 145000.0 1.23 242840.0 156000.0 1.29 1.7842 0.9997 2060194 SPBio_000809 COc1cc(O)c(C(=O)O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I12 compound treatment 277760.0 179000.0 1.52 323240.0 236000.0 1.96 2.4595 0.9924 1013 SPBio_000810 Cc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I13 compound treatment 255240.0 156000.0 1.33 279920.0 193000.0 1.6 2.0705 0.9959 1514 SPBio_000811 CC1OC1P(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I14 compound treatment 173400.0 74500.0 0.63 205040.0 118000.0 0.98 1.1398 0.9781 1005991 SPBio_000812 O=C1c2ccccc2-c3cccc4cccc1c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I15 compound treatment 18280.0 -80600.0 -0.69 20280.0 -66600.0 -0.55 -0.8749 -0.9941 1191 SPBio_000813 Oc1c(Cl)cc(Cl)c2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I16 compound treatment 146920.0 48000.0 0.41 201280.0 114000.0 0.95 0.9583 0.9296 2777 SPBio_000814 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I17 compound treatment 199320.0 100000.0 0.86 199760.0 113000.0 0.93 1.2649 0.999 3172720 SPBio_000815 CNC(C)[C@@H]1CC[C@@H](N)[C@@H](OC2[C@@H](N)C[C@@H](N)[C@H](OC3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I18 compound treatment 143040.0 44200.0 0.38 134720.0 47800.0 0.4 0.5456 0.9997 1294 SPBio_000816 CCN(CC)Cc1ccc(Nc2ccnc3cc(Cl)ccc23)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I19 compound treatment 95600.0 -3290.0 -0.03 84240.0 -2650.0 -0.02 -0.0353 -0.9927 927 SPBio_000817 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I20 compound treatment 238640.0 140000.0 1.19 202080.0 115000.0 0.95 1.5152 0.9939 1092 SPBio_000818 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I21 compound treatment 139080.0 40200.0 0.34 127920.0 41000.0 0.34 0.482 1.0 1019607 SPBio_000819 CN(C)Cc1c(C)[nH]c2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I22 compound treatment 114880.0 16000.0 0.14 126480.0 39600.0 0.33 0.3279 0.9244 446 SPBio_000820 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I23 mock treatment 144040.0 45200.0 0.38 112200.0 25300.0 0.21 0.4199 0.9592 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 I24 mock treatment 15800.0 -83100.0 -0.71 32160.0 -54700.0 -0.45 -0.8204 -0.9767 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J01 mock treatment 53360.0 -45500.0 -0.39 39720.0 -47200.0 -0.39 -0.55 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J02 mock treatment 105400.0 6520.0 0.06 68600.0 -18300.0 -0.15 -0.0678 -0.4205 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J03 compound treatment 139560.0 40700.0 0.35 142520.0 55600.0 0.46 0.5703 0.9902 1175 SPBio_000821 Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J04 compound treatment 204840.0 106000.0 0.9 187400.0 101000.0 0.83 1.2259 0.9992 3172714 SPBio_000822 C[n+]1ccccc1/C=N/O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J05 compound treatment 185600.0 86700.0 0.74 135160.0 48300.0 0.4 0.8044 0.9584 856 SPBio_000823 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J06 compound treatment 228560.0 130000.0 1.1 214680.0 128000.0 1.06 1.5282 0.9998 1000105 SPBio_000824 CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J07 compound treatment 223720.0 125000.0 1.06 194000.0 107000.0 0.89 1.3781 0.9959 1000127 SPBio_000825 CC1(C)O[C@@H]2CC3C4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J08 compound treatment 235000.0 136000.0 1.16 191160.0 104000.0 0.86 1.4294 0.9894 3471036 SPBio_000826 OC(=O)C1=C(C[n+]2ccccc2)CSC3C(NC(=O)Cc4cccs4)C(=O)N31 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J09 compound treatment 230920.0 132000.0 1.12 202520.0 116000.0 0.96 1.4713 0.9968 1053 SPBio_000827 COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J10 compound treatment 40040.0 -58800.0 -0.5 38000.0 -48900.0 -0.4 -0.6403 -0.9944 1338 SPBio_000828 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J11 compound treatment 240040.0 141000.0 1.2 225000.0 138000.0 1.14 1.6577 0.9997 938 SPBio_000829 Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J12 compound treatment 244280.0 145000.0 1.24 282400.0 196000.0 1.62 2.019 0.9913 1107 SPBio_000830 OC(=O)CN1CCNC1=N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J13 compound treatment 273840.0 175000.0 1.49 275960.0 189000.0 1.56 2.1593 0.9997 1146 SPBio_000831 Nc1ccc(cc1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J14 compound treatment 262000.0 163000.0 1.39 234440.0 148000.0 1.22 1.8452 0.9979 1271 SPBio_000832 CC(=O)OC(CC(=O)O)[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J15 compound treatment 219880.0 121000.0 1.03 210840.0 124000.0 1.03 1.4535 1.0 721 SPBio_000833 CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J16 compound treatment 181120.0 82200.0 0.7 198360.0 111000.0 0.92 1.1472 0.9908 1142 SPBio_000834 Cc1cn([C@H]2C[C@H](N=[N+]=[N-])[C@@H](CO)O2)c(=O)[nH]c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J17 compound treatment 200120.0 101000.0 0.86 196720.0 110000.0 0.91 1.252 0.9997 2060131 SPBio_000835 CCOC(=O)c1oc2c(OC)c(O)cc(O)c2c(=O)c1c3cc(OC)c(OC)c(OC)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J18 compound treatment 209280.0 110000.0 0.94 193160.0 106000.0 0.88 1.2863 0.9994 725 SPBio_000836 CC(=C)[C@@H]1CCC(=CC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J19 compound treatment 221560.0 123000.0 1.04 219160.0 132000.0 1.09 1.5123 0.9997 3044782 SPBio_000837 NC(=N)N.OC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J20 compound treatment 239360.0 140000.0 1.2 211600.0 125000.0 1.03 1.5752 0.9973 1372 SPBio_000838 OC(=O)c1cccnc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J21 compound treatment 129680.0 30800.0 0.26 141840.0 55000.0 0.45 0.5068 0.9658 1429 SPBio_000839 CCCCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J22 compound treatment 109560.0 10700.0 0.09 95760.0 8870.0 0.07 0.1162 0.9944 937 SPBio_000840 CCC(=O)c1ccc2Sc3ccccc3N(CC(C)N(C)C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J23 mock treatment 131160.0 32300.0 0.27 159760.0 72900.0 0.6 0.6206 0.9367 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 J24 mock treatment 25840.0 -73000.0 -0.62 39600.0 -47300.0 -0.39 -0.7164 -0.975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K01 mock treatment 36840.0 -62000.0 -0.53 31360.0 -55500.0 -0.46 -0.6984 -0.9976 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K02 mock treatment 108240.0 9360.0 0.08 88600.0 1710.0 0.01 0.0663 0.8199 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K03 compound treatment 143320.0 44400.0 0.38 102520.0 15600.0 0.13 0.359 0.8978 3054976 SPBio_000841 CC(C)[C@@H]1CC[C@@H](C)CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K04 compound treatment 136000.0 37100.0 0.32 125200.0 38300.0 0.32 0.4476 1.0 3173242 SPBio_000842 Nc1nc2cc(Cl)ccc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K05 compound treatment 180880.0 82000.0 0.7 141880.0 55000.0 0.45 0.8153 0.9785 2060306 SPBio_000843 C[C@@H](CCOC(=O)C)CCC=C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K06 compound treatment 147920.0 49000.0 0.42 128080.0 41200.0 0.34 0.5362 0.9949 2060291 SPBio_000844 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)CC[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K07 compound treatment 192080.0 93200.0 0.79 164320.0 77400.0 0.64 1.014 0.9944 3235 SPBio_000845 OC(=O)c1ccccc1OC(=O)c2ccccc2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K08 compound treatment 176960.0 78100.0 0.66 125080.0 38200.0 0.32 0.6935 0.9422 1156 SPBio_000846 OC(=O)c1cc(O)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K09 compound treatment 15200.0 -83700.0 -0.71 13480.0 -73400.0 -0.61 -0.9333 -0.9968 3177523 SPBio_000847 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O)[C@H](C)O2)N(C)C)c3c(O)c4C(=O)c5c(O)ccc(O)c5C(=O)c4cc3[C@H]1C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K10 compound treatment 98960.0 75.0 0.0 110080.0 23200.0 0.19 0.1361 0.7095 1308020 SPBio_000848 COc1ccc(cc1)c2cc(=O)c3ccccc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K11 compound treatment 50960.0 -47900.0 -0.41 50440.0 -36500.0 -0.3 -0.5018 -0.9889 1056 SPBio_000849 Nc1nc2nc[nH]c2c(=S)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K12 compound treatment 232720.0 134000.0 1.14 244600.0 158000.0 1.3 1.7283 0.9977 1599 SPBio_000850 C=CCc1ccc2OCOc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K13 compound treatment 252680.0 154000.0 1.31 306720.0 220000.0 1.82 2.2119 0.987 999 SPBio_000851 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K14 compound treatment 229760.0 131000.0 1.11 239160.0 152000.0 1.26 1.6787 0.9981 3058468 SPBio_000852 COc1ccc(OC)c(c1)C(O)C(C)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K15 compound treatment 14160.0 -84700.0 -0.72 14440.0 -72500.0 -0.6 -0.9339 -0.9958 1356 SPBio_000853 Oc1cccc2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K16 compound treatment 133680.0 34800.0 0.3 138000.0 51100.0 0.42 0.5085 0.9849 2553 SPBio_000854 CNNC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K17 compound treatment 13120.0 -85800.0 -0.73 12960.0 -73900.0 -0.61 -0.9488 -0.9961 3198320 SPBio_000855 Clc1ccc(CO/N=C(\Cn2ccnc2)/c3ccc(Cl)cc3Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K18 compound treatment 80920.0 -18000.0 -0.15 108400.0 21500.0 0.18 0.0177 0.0753 422 SPBio_000856 Oc1cccc2C(=O)C=CC(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K19 compound treatment 218200.0 119000.0 1.02 197600.0 111000.0 0.92 1.366 0.9987 3047 SPBio_000857 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(=C3[C@H]2OC1=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K20 compound treatment 152040.0 53200.0 0.45 144640.0 57800.0 0.48 0.6578 0.9996 3198324 SPBio_000858 C[C@@H]1O[C@@H](OC[C@H]2OC(Oc3c(oc4cc(O)cc(O)c4c3=O)c5ccc(O)c(O)c5)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K21 compound treatment 128840.0 30000.0 0.26 131720.0 44800.0 0.37 0.4426 0.9833 1003215 SPBio_000859 CC(C)C1=CC(=O)C(=CC1=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K22 compound treatment 89360.0 -9530.0 -0.08 67400.0 -19500.0 -0.16 -0.1714 -0.9494 1330 SPBio_000860 ClCCN(CCCl)CCCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K23 mock treatment 116920.0 18000.0 0.15 108880.0 22000.0 0.18 0.2372 0.9964 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 K24 mock treatment 43760.0 -55100.0 -0.47 36640.0 -50300.0 -0.42 -0.6258 -0.9982 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L01 mock treatment 37400.0 -61500.0 -0.52 30680.0 -56200.0 -0.47 -0.699 -0.9983 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L02 mock treatment 83120.0 -15800.0 -0.13 71920.0 -15000.0 -0.12 -0.1825 -0.9992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L03 compound treatment 105640.0 6760.0 0.06 87640.0 750.0 0.01 0.0451 0.7789 930 SPBio_000861 CC(CN1CCCCC1)C(=O)c2ccc(C)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L04 compound treatment 139360.0 40500.0 0.34 104840.0 18000.0 0.15 0.3487 0.9292 1325 SPBio_000862 NC1(CCCC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L05 compound treatment 79440.0 -19400.0 -0.17 65440.0 -21500.0 -0.18 -0.2425 -0.9994 2576 SPBio_000863 S=C=NCc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L06 compound treatment 195280.0 96400.0 0.82 129080.0 42200.0 0.35 0.8271 0.9274 3173241 SPBio_000864 C[C@@]12CCC3C(CC[C@H]4C[C@@H](CC[C@@]43C)OS(=O)(=O)O)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L07 compound treatment 179560.0 80700.0 0.69 139800.0 52900.0 0.44 0.7952 0.9763 1099 SPBio_000865 CC(=O)NCCCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L08 compound treatment 199720.0 101000.0 0.86 152840.0 66000.0 0.55 0.9929 0.9761 1266 SPBio_000866 CCn1cc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L09 compound treatment 135920.0 37000.0 0.32 111040.0 24200.0 0.2 0.3642 0.9758 850 SPBio_000867 Clc1cccc(c1)N2CCN(CCCn3nc4ccccn4c3=O)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L10 compound treatment 203360.0 104000.0 0.89 195960.0 109000.0 0.9 1.267 1.0 1081 SPBio_000868 Cc1c(N)c(=O)n(c2ccccc2)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L11 compound treatment 209080.0 110000.0 0.94 209240.0 122000.0 1.01 1.3791 0.9993 1413 SPBio_000869 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L12 compound treatment 228880.0 130000.0 1.11 260400.0 174000.0 1.44 1.7976 0.9918 1000116 SPBio_000870 CC(=O)CC(c1ccccc1)c2c(O)c3ccccc3oc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L13 compound treatment 292680.0 194000.0 1.65 308480.0 222000.0 1.83 2.463 0.9986 1433 SPBio_000871 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L14 compound treatment 187680.0 88800.0 0.76 164800.0 77900.0 0.64 0.9903 0.9968 1075 SPBio_000872 CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L15 compound treatment 26360.0 -72500.0 -0.62 20440.0 -66500.0 -0.55 -0.8253 -0.9983 801 SPBio_000873 CN(C)CC/C=C/1\c2ccccc2Sc3ccc(Cl)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L16 compound treatment 109240.0 10400.0 0.09 112480.0 25600.0 0.21 0.212 0.9246 1201 SPBio_000874 COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L17 compound treatment 162360.0 63500.0 0.54 130040.0 43200.0 0.36 0.6346 0.9797 1278 SPBio_000875 COc1ccc(cc1O)c2cc(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@H]5O[C@H](C)[C@@H](O)[C@H](O)[C@@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L18 compound treatment 119000.0 20100.0 0.17 112640.0 25800.0 0.21 0.2717 0.9941 1061 SPBio_000876 Nc1nc(N)c2nc(c(N)nc2n1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L19 compound treatment 200280.0 101000.0 0.86 164520.0 77600.0 0.64 1.0646 0.9894 3177517 SPBio_000877 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)C(O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L20 compound treatment 176400.0 77500.0 0.66 136760.0 49900.0 0.41 0.7584 0.9744 1341 SPBio_000878 CC(=O)OCC(COC(=O)C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L21 compound treatment 147280.0 48400.0 0.41 104200.0 17300.0 0.14 0.3926 0.9 1162 SPBio_000879 Cc1c(NC(=O)c2cccnc2)c(=O)n(c3ccccc3)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L22 compound treatment 7720.0 -91200.0 -0.78 6840.0 -80100.0 -0.66 -1.0171 -0.9969 3173364 SPBio_000880 C[C@H]1[C@@]2(C)CCC3C(CCC4C[C@H](CC[C@@]43C)O[C@H]5O[C@H](CO)[C@H](O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O[C@H]7OC[C@@H](O)[C@H](O)[C@H]7O[C@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@H]6O)[C@H](O)[C@H]5O)C2O[C@]91CC[C@H](C)CN9 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L23 mock treatment 92840.0 -6050.0 -0.05 76440.0 -10500.0 -0.09 -0.0975 -0.9693 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 L24 mock treatment 44880.0 -54000.0 -0.46 59200.0 -27700.0 -0.23 -0.4871 -0.9482 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M01 mock treatment 41200.0 -57700.0 -0.49 36680.0 -50200.0 -0.42 -0.641 -0.9965 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M02 mock treatment 87040.0 -11800.0 -0.1 81360.0 -5530.0 -0.05 -0.1037 -0.9361 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M03 compound treatment 74440.0 -24400.0 -0.21 67200.0 -19700.0 -0.16 -0.2624 -0.9926 3174245 SPBio_000881 OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc3ccc(O)cc3)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M04 compound treatment 10920.0 -88000.0 -0.75 8400.0 -78500.0 -0.65 -0.9887 -0.9975 1019365 SPBio_000882 COC1=CC(=O)C=C(OC)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M05 compound treatment 77840.0 -21000.0 -0.18 63080.0 -23800.0 -0.2 -0.266 -0.9989 2060246 SPBio_000883 C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H](C/C=C/3\[C@H](O)COC3=O)C(=C)CCC12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M06 compound treatment 114680.0 15800.0 0.13 76920.0 -9970.0 -0.08 0.0368 0.2331 2081029 SPBio_000884 CN/C(=N\C#N)/NCCSCc1nc[nH]c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M07 compound treatment 112280.0 13400.0 0.11 58240.0 -28700.0 -0.24 -0.0869 -0.3306 907310 SPBio_000885 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M08 compound treatment 120080.0 21200.0 0.18 81000.0 -5890.0 -0.05 0.0932 0.4983 2060352 SPBio_000886 O=C(O[C@H]1Cc2c(OC(=O)c3ccccc3)cc(OC(=O)c4ccccc4)cc2O[C@@H]1c5ccc(OC(=O)c6ccccc6)c(OC(=O)c7ccccc7)c5)c8ccccc8 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M09 compound treatment 109760.0 10900.0 0.09 76680.0 -10200.0 -0.08 0.0057 0.0459 3057880 SPBio_000887 COc1ccc(cc1)C(=C(c2ccc(OC)cc2)c3ccc(OC)cc3)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M10 compound treatment 105840.0 6960.0 0.06 73440.0 -13500.0 -0.11 -0.0368 -0.292 847 SPBio_000888 CC(=CCC/C(=C/CO)/C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M11 compound treatment 178440.0 79600.0 0.68 158400.0 71500.0 0.59 0.8973 0.9977 3060195 SPBio_000889 COC(C)(C)CCC[C@H](C)C/C=C/C(=C/C(=O)OC(C)C)/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M12 compound treatment 158040.0 59200.0 0.5 159120.0 72200.0 0.6 0.7787 0.9964 1029 SPBio_000890 CC(C(=O)O)c1ccc(cc1)N2Cc3ccccc3C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M13 compound treatment 225840.0 127000.0 1.08 235320.0 148000.0 1.23 1.6326 0.998 3173342 SPBio_000891 CO/N=C(/C(=O)NC1C2SCC(=C(N2C1=O)C(=O)O)COC(=O)N)\c3ccco3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M14 compound treatment 36960.0 -61900.0 -0.53 51640.0 -35300.0 -0.29 -0.579 -0.961 784 SPBio_000892 Nc1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M15 compound treatment 119040.0 20200.0 0.17 108800.0 21900.0 0.18 0.2495 0.9996 370 SPBio_000893 O=C1N(C2CCC(=O)NC2=O)C(=O)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M16 compound treatment 17760.0 -81100.0 -0.69 12480.0 -74400.0 -0.62 -0.9237 -0.9983 1195 SPBio_000894 C[C@@]12CCC3C(CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]2(O)CCC1C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M17 compound treatment 8040.0 -90800.0 -0.77 7240.0 -79700.0 -0.66 -1.0129 -0.9968 3198321 SPBio_000895 CCCCCCCC/C=C/CCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M18 compound treatment 112040.0 13200.0 0.11 80320.0 -6570.0 -0.05 0.0408 0.3275 1256 SPBio_000896 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M19 compound treatment 99960.0 1080.0 0.01 86600.0 -290.0 0.0 0.0048 0.5047 1713087 SPBio_000897 COc1ccc(cc1OC)c2cc(=O)c3ccccc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M20 compound treatment 84840.0 -14000.0 -0.12 56560.0 -30300.0 -0.25 -0.262 -0.9425 41 SPBio_000898 OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M21 compound treatment 110560.0 11700.0 0.1 97120.0 10200.0 0.08 0.1301 0.9968 3058622 SPBio_000899 OC1=CC2=C3c4ccc(O)cc4OC[C@]3(O)CC2=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M22 compound treatment 22800.0 -76100.0 -0.65 22720.0 -64200.0 -0.53 -0.8334 -0.9951 2060048 SPBio_000900 CC(=O)c1c(O)c(C)c(O)c2c1oc3c(C(=O)C)c(O)c(C)c(O)c32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M23 mock treatment 102600.0 3720.0 0.03 76080.0 -10800.0 -0.09 -0.0409 -0.4308 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 M24 mock treatment 46400.0 -52500.0 -0.45 45040.0 -41900.0 -0.35 -0.5608 -0.992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N01 mock treatment 64520.0 -34400.0 -0.29 76280.0 -10600.0 -0.09 -0.269 -0.8805 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N02 mock treatment 94880.0 -4010.0 -0.03 96680.0 9790.0 0.08 0.0332 0.3773 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N03 compound treatment 80200.0 -18700.0 -0.16 74400.0 -12500.0 -0.1 -0.1856 -0.9782 860 SPBio_000901 CN(C)C(=O)Oc1ccc[n+](C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N04 compound treatment 78400.0 -20500.0 -0.17 65880.0 -21000.0 -0.17 -0.2462 -1.0 2407 SPBio_000902 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ncc(C)s3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N05 compound treatment 71760.0 -27100.0 -0.23 56040.0 -30900.0 -0.26 -0.3438 -0.9988 1268 SPBio_000903 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3cc(C)on3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N06 compound treatment 57640.0 -41200.0 -0.35 67120.0 -19800.0 -0.16 -0.364 -0.9395 811 SPBio_000904 CC(=O)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N07 compound treatment 109640.0 10800.0 0.09 71320.0 -15600.0 -0.13 -0.0263 -0.1666 1100 SPBio_000905 CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N08 compound treatment 7480.0 -91400.0 -0.78 5440.0 -81500.0 -0.67 -1.0268 -0.9974 928 SPBio_000906 CC(=O)O[Hg]c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N09 compound treatment 6880.0 -92000.0 -0.78 6200.0 -80700.0 -0.67 -1.0259 -0.9968 3173346 SPBio_000907 CC[C@H](C1OC(CC)(C[C@@H]1C)C2CC[C@](O)(CC)[C@H](C)O2)C(=O)C(C)[C@@H](O)[C@H](C)CCc3ccc(C)c(O)c3C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N10 compound treatment 9120.0 -89800.0 -0.76 7240.0 -79700.0 -0.66 -1.0064 -0.9973 1374 SPBio_000908 Oc1c(Br)cc(Br)c2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N11 compound treatment 135880.0 37000.0 0.31 96960.0 10100.0 0.08 0.2816 0.8644 1274 SPBio_000909 C1CN2C[C@@H](N=C2S1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N12 compound treatment 185840.0 87000.0 0.74 181680.0 94800.0 0.78 1.078 0.9996 816 SPBio_000910 Cc1cc(cc(C)c1CC2=NCCN2)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N13 compound treatment 222800.0 124000.0 1.06 214920.0 128000.0 1.06 1.495 1.0 1232 SPBio_000911 OC1=C(O)C(=O)C(=C(O)C1=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N14 compound treatment 160160.0 61300.0 0.52 134160.0 47300.0 0.39 0.6454 0.9899 471 SPBio_000912 CCCC(CCC)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N15 compound treatment 9240.0 -89600.0 -0.76 8600.0 -78300.0 -0.65 -0.9977 -0.9967 1051 SPBio_000913 CC(=O)Oc1ccc(Cl)c2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N16 compound treatment 92840.0 -6050.0 -0.05 74720.0 -12200.0 -0.1 -0.1076 -0.9515 1044 SPBio_000914 C[C@H](CCC(=O)O)[C@H]1CCC2C3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N17 compound treatment 50400.0 -48500.0 -0.41 41480.0 -45400.0 -0.38 -0.5575 -0.9989 975 SPBio_000915 CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N18 compound treatment 46520.0 -52400.0 -0.45 42920.0 -44000.0 -0.36 -0.5725 -0.9949 1000 SPBio_000916 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N19 compound treatment 57240.0 -41600.0 -0.35 51840.0 -35100.0 -0.29 -0.4558 -0.995 798 SPBio_000917 CCCCCCOc1ccccc1C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N20 compound treatment 104600.0 5720.0 0.05 63560.0 -23300.0 -0.19 -0.1021 -0.5128 977 SPBio_000918 C[C@@]12C[C@H](O)[C@@]3(F)C(CCC4=CC(=O)C=C[C@@]43C)C2C[C@@H](O)[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N21 compound treatment 82760.0 -16100.0 -0.14 77960.0 -8930.0 -0.07 -0.1493 -0.9577 1000115 SPBio_000919 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N22 compound treatment 99040.0 155.0 0.0 103600.0 16700.0 0.14 0.0987 0.7138 971 SPBio_000920 CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N23 mock treatment 67400.0 -31500.0 -0.27 85040.0 -1850.0 -0.02 -0.2004 -0.7463 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 N24 mock treatment 61360.0 -37500.0 -0.32 77200.0 -9690.0 -0.08 -0.2826 -0.8579 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O01 mock treatment 67760.0 -31100.0 -0.27 75080.0 -11800.0 -0.1 -0.2565 -0.9081 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O02 mock treatment 78600.0 -20300.0 -0.17 56480.0 -30400.0 -0.25 -0.3 -0.9832 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O03 compound treatment 82480.0 -16400.0 -0.14 79320.0 -7570.0 -0.06 -0.143 -0.9345 1053058 SPBio_000921 COc1cc(OC)c2c(=O)c(O)c(oc2c1)c3ccc(OC)c(OC)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O04 compound treatment 60440.0 -38400.0 -0.33 43040.0 -43900.0 -0.36 -0.488 -0.9987 1003514 SPBio_000922 COc1cc(cc(OC)c1OC)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O05 compound treatment 6240.0 -92600.0 -0.79 4440.0 -82500.0 -0.68 -1.0401 -0.9974 3055171 SPBio_000923 COC(=O)[C@]1(C)CC[C@]2(C)CC[C@]3(C)C4=CCc5c(C)c(O)c(O)cc5[C@]4(C)CC[C@@]3(C)C2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O06 compound treatment 64240.0 -34600.0 -0.29 53480.0 -33400.0 -0.28 -0.404 -0.9995 2060483 SPBio_000924 CC(=O)N[C@@H](CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O07 compound treatment 46680.0 -52200.0 -0.44 35280.0 -51600.0 -0.43 -0.6162 -0.9998 2069289 SPBio_000925 CC(=O)Oc1cc2c(CC3OC34[C@@]2(C)CC[C@@]5(C)C6C[C@@](C)(CC[C@]6(C)CC[C@]45C)C(=O)O)c(C)c1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O08 compound treatment 51440.0 -47400.0 -0.4 35120.0 -51800.0 -0.43 -0.5885 -0.9996 3078273 SPBio_000926 COc1cc(C)c(C(=O)Oc2cc(C)c(O)c(C(=O)O)c2C)c(O)c1C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O09 compound treatment 46360.0 -52500.0 -0.45 41040.0 -45900.0 -0.38 -0.5844 -0.9966 3198322 SPBio_000927 CC1CNC(=O)CCC2(C)C(CC(=O)N)C3N4C2=C(C)C5=N6C(=CC7=N8C(=C(C)C9=N(C3(C)C(C)(CC(=O)N)C9CCC(=O)N)[Co+]486(C[C@H]%10OC([C@H](O)[C@@H]%10O)n%11cnc%12c(N)ncnc%11%12)N%13=CN(C%14O[C@H](CO)[C@@H](OP(=O)(O)O1)[C@H]%14O)c%15cc(C)c(C)cc%13%15)C(C)(CC(=O)N)C7CCC(=O)N)C(C)(C)C5CCC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O10 compound treatment 60240.0 -38600.0 -0.33 39160.0 -47700.0 -0.39 -0.5119 -0.9959 112 SPBio_000928 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O11 compound treatment 100880.0 2000.0 0.02 73720.0 -13200.0 -0.11 -0.065 -0.5897 1538 SPBio_000929 Oc1ccc(c(O)c1)c2oc3cc(O)cc(O)c3c(=O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O12 compound treatment 127240.0 28400.0 0.24 141240.0 54400.0 0.45 0.4886 0.9575 3198325 SPBio_000930 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O13 compound treatment 198080.0 99200.0 0.84 219800.0 133000.0 1.1 1.3747 0.9915 1343 SPBio_000931 COC1=CC(C)[C@@H]2C[C@H]3OC(=O)C[C@H]4C(=C(OC)C(=O)C([C@@]34C)[C@@]2(C)C1=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O14 compound treatment 118680.0 19800.0 0.17 123440.0 36600.0 0.3 0.333 0.9619 2080198 SPBio_000932 CC(=O)C1=C(O)C2C3C(Cc4cccc5[nH]cc3c45)C(C)(C)N2C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O15 compound treatment 77720.0 -21200.0 -0.18 76120.0 -10800.0 -0.09 -0.1904 -0.9473 2069234 SPBio_000933 CN1CCc2cc3OCOc3cc2[C@H]1C4OC(=O)c5c6OCOc6ccc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O16 compound treatment 61200.0 -37700.0 -0.32 53800.0 -33100.0 -0.27 -0.4204 -0.9969 1353 SPBio_000934 COC(=O)/C(=C/1\OC(=O)C(C1=O)c2ccccc2)/c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O17 compound treatment 17480.0 -81400.0 -0.69 11600.0 -75300.0 -0.62 -0.9305 -0.9986 3078269 SPBio_000935 OCC(O)CC(O)CCCCCCCCCCCC=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O18 compound treatment 25680.0 -73200.0 -0.62 33560.0 -53300.0 -0.44 -0.7527 -0.9857 2060168 SPBio_000936 C/C(=C/CC1[C@](C)(O)CC[C@H]2C(C)(C)CCC[C@]12C)/C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O19 compound treatment 65040.0 -33800.0 -0.29 53800.0 -33100.0 -0.27 -0.3973 -0.9997 1000122 SPBio_000937 O[C@@H]([C@@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O20 compound treatment 5560.0 -93300.0 -0.79 5200.0 -81700.0 -0.68 -1.0397 -0.9968 1576 SPBio_000938 CC(=CCc1c(O)c2c(=O)c(coc2c3C=CC(C)(C)Oc13)c4ccc(O)c(O)c4)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O21 compound treatment 75920.0 -23000.0 -0.2 88560.0 1670.0 0.01 -0.1285 -0.6555 1601 SPBio_000939 COc1c(OC)c2ccc(=O)oc2c3ccoc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O22 compound treatment 83840.0 -15000.0 -0.13 118080.0 31200.0 0.26 0.0919 0.3189 994 SPBio_000940 N[C@@H](CCONC(=N)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O23 mock treatment 54560.0 -44300.0 -0.38 100000.0 13100.0 0.11 -0.1902 -0.4843 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 O24 mock treatment 61120.0 -37800.0 -0.32 75040.0 -11900.0 -0.1 -0.2967 -0.8826 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P01 mock treatment 69600.0 -29300.0 -0.25 71680.0 -15200.0 -0.13 -0.2653 -0.9498 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P02 mock treatment 70080.0 -28800.0 -0.25 59680.0 -27200.0 -0.23 -0.3326 -0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P03 compound treatment 77680.0 -21200.0 -0.18 78000.0 -8890.0 -0.07 -0.1797 -0.9216 1000112 SPBio_000941 CC(=O)O[C@H]1[C@@H](O)C2C(C)(C)CC[C@H](O)[C@]2(C)[C@@]3(O)C(=O)C[C@@](C)(O[C@]13C)C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P04 compound treatment 37200.0 -61700.0 -0.53 42040.0 -44900.0 -0.37 -0.6337 -0.9855 1000129 SPBio_000942 CC1(C)[C@H](CC[C@@]2(C)C1CC[C@]3(C)C2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P05 compound treatment 76840.0 -22000.0 -0.19 67560.0 -19300.0 -0.16 -0.2458 -0.9968 1000045 SPBio_000943 CC(=O)O[C@@H]1C2=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c3ccccc3)C4[C@@]5(CO[C@@H]5C[C@H](O)[C@@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P06 compound treatment 51040.0 -47800.0 -0.41 47000.0 -39900.0 -0.33 -0.5214 -0.9945 1004 SPBio_000944 Oc1ccc2c(=O)cc(oc2c1O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P07 compound treatment 30040.0 -68800.0 -0.59 25000.0 -61900.0 -0.51 -0.7765 -0.9977 1450 SPBio_000945 NCCc1c[nH]c2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P08 compound treatment 7040.0 -91800.0 -0.78 8120.0 -78800.0 -0.65 -1.0137 -0.9959 922 SPBio_000946 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P09 compound treatment 43680.0 -55200.0 -0.47 38640.0 -48300.0 -0.4 -0.6146 -0.9967 1586 SPBio_000947 NCCCCNCCCN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P10 compound treatment 15000.0 -83900.0 -0.71 11400.0 -75500.0 -0.62 -0.9466 -0.9978 1106 SPBio_000948 CCC(=O)c1c(O)cc(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P11 compound treatment 54240.0 -44600.0 -0.38 39600.0 -47300.0 -0.39 -0.5454 -0.9999 831758 SPBio_000949 Oc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P12 compound treatment 138400.0 39500.0 0.34 123080.0 36200.0 0.3 0.4496 0.9983 1533 SPBio_000950 Cc1cc(CC(=O)O)n(C)c1C(=O)c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P13 compound treatment 76760.0 -22100.0 -0.19 67240.0 -19700.0 -0.16 -0.2482 -0.9973 1898 SPBio_000951 OC(=O)CC[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P14 compound treatment 84440.0 -14400.0 -0.12 71920.0 -15000.0 -0.12 -0.1745 -1.0 1209 SPBio_000952 CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P15 compound treatment 64800.0 -34100.0 -0.29 38160.0 -48700.0 -0.4 -0.4903 -0.987 1089854 SPBio_000953 Cc1ncc(CNC(=O)N(CCCl)N=O)c(N)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P16 compound treatment 36480.0 -62400.0 -0.53 29520.0 -57400.0 -0.47 -0.7113 -0.9984 1152 SPBio_000954 CN(C)CCN(Cc1ccccc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P17 compound treatment 52120.0 -46800.0 -0.4 47280.0 -39600.0 -0.33 -0.5133 -0.9953 1001531 SPBio_000955 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P18 compound treatment 3560.0 -95300.0 -0.81 3680.0 -83200.0 -0.69 -1.0607 -0.9966 3044756 SPBio_000956 CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P19 compound treatment 39840.0 -59000.0 -0.5 43960.0 -42900.0 -0.36 -0.6066 -0.9855 831 SPBio_000957 Nc1nccs1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P20 compound treatment 48160.0 -50700.0 -0.43 48600.0 -38300.0 -0.32 -0.5294 -0.9884 1000123 SPBio_000958 CC(=O)OCC(=O)[C@@]1(O)[C@@H](CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P21 compound treatment 68080.0 -30800.0 -0.26 73360.0 -13500.0 -0.11 -0.2646 -0.9279 1249 SPBio_000959 C[N+](C)(C)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P22 compound treatment 75640.0 -23200.0 -0.2 72800.0 -14100.0 -0.12 -0.2224 -0.9681 1200 SPBio_000960 NC1C[C@H]1c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P23 mock treatment 75040.0 -23800.0 -0.2 59920.0 -27000.0 -0.22 -0.3013 -0.9989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2160 P24 mock treatment 48560.0 -50300.0 -0.43 49640.0 -37300.0 -0.31 -0.5209 -0.9869 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A01 mock treatment 56440.0 -31100.0 -0.27 105520.0 -32200.0 -0.27 -0.3756 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A02 mock treatment 110040.0 22500.0 0.19 150760.0 13100.0 0.11 0.2117 0.9634 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A03 compound treatment 159320.0 71800.0 0.61 126120.0 -11600.0 -0.1 0.3643 0.5891 1002 SPBio_000961 CN(C)CCOC(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A04 compound treatment 11680.0 -75900.0 -0.65 8040.0 -130000.0 -1.07 -1.2153 -0.9706 778 SPBio_000962 Oc1c(I)cc(I)c2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A05 compound treatment 11120.0 -76400.0 -0.65 6280.0 -131000.0 -1.09 -1.229 -0.9699 979 SPBio_000963 S=C1CC=CC=N1O[Zn]On2ccccc2=S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A06 compound treatment 245240.0 158000.0 1.34 80120.0 -57600.0 -0.48 0.6125 0.43 1244 SPBio_000964 C[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A07 compound treatment 237880.0 150000.0 1.28 46360.0 -91300.0 -0.76 0.3707 0.2494 1216 SPBio_000965 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2C[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A08 compound treatment 284880.0 197000.0 1.68 79640.0 -58100.0 -0.48 0.8483 0.4855 890 SPBio_000966 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A09 compound treatment 264040.0 176000.0 1.5 64880.0 -72800.0 -0.6 0.6365 0.3932 3177385 SPBio_000967 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A10 compound treatment 271800.0 184000.0 1.57 74320.0 -63400.0 -0.52 0.7385 0.4465 1406 SPBio_000968 NC(=O)c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A11 compound treatment 281720.0 194000.0 1.65 107200.0 -30500.0 -0.25 0.9905 0.5923 858 SPBio_000969 OCC(O)CN1CCN(CC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A12 compound treatment 195240.0 108000.0 0.92 127000.0 -10700.0 -0.09 0.5857 0.6359 1123 SPBio_000970 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A13 compound treatment 255000.0 167000.0 1.43 139480.0 1780.0 0.01 1.0185 0.7144 827 SPBio_000971 CCCCC1(COC(=O)CCC(=O)O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A14 compound treatment 308200.0 221000.0 1.88 97640.0 -40100.0 -0.33 1.094 0.5735 3173466 SPBio_000972 [O-][N+](=O)c1ccc(/C=N/N2CC(=O)NC2=O)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A15 compound treatment 214680.0 127000.0 1.08 64280.0 -73400.0 -0.61 0.3358 0.2706 770 SPBio_000973 CC(CCc1ccccc1)NC(C)C(O)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A16 compound treatment 252880.0 165000.0 1.41 79320.0 -58400.0 -0.48 0.6538 0.4394 1077 SPBio_000974 CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A17 compound treatment 232680.0 145000.0 1.24 67800.0 -69900.0 -0.58 0.4648 0.3407 950 SPBio_000975 Oc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A18 compound treatment 14000.0 -73600.0 -0.63 5640.0 -132000.0 -1.09 -1.2154 -0.9651 814 SPBio_000976 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A19 compound treatment 254000.0 166000.0 1.42 74400.0 -63300.0 -0.52 0.6318 0.4182 776 SPBio_000977 NNc1nncc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A20 compound treatment 257480.0 170000.0 1.45 74120.0 -63600.0 -0.53 0.6511 0.423 3173600 SPBio_000978 Oc1ccc2C[C@H]3N(CC=C)CC[C@]4(C5Oc1c24)[C@@]3(O)CCC5=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A21 compound treatment 174120.0 86600.0 0.74 107800.0 -29900.0 -0.25 0.3462 0.4454 2797 SPBio_000979 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A22 compound treatment 149560.0 62000.0 0.53 135160.0 -2540.0 -0.02 0.3584 0.6785 404 SPBio_000980 CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A23 mock treatment 112360.0 24800.0 0.21 134440.0 -3260.0 -0.03 0.1302 0.6119 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 A24 mock treatment 58960.0 -28600.0 -0.24 151040.0 13300.0 0.11 -0.0942 -0.3522 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B01 mock treatment 125760.0 38200.0 0.33 176080.0 38400.0 0.32 0.4545 0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B02 mock treatment 178520.0 91000.0 0.77 127280.0 -10400.0 -0.09 0.4867 0.6246 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B03 compound treatment 215760.0 128000.0 1.09 129880.0 -7820.0 -0.06 0.7261 0.664 1008060 SPBio_000981 C1CCc2nnnn2CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B04 compound treatment 211240.0 124000.0 1.05 106960.0 -30700.0 -0.25 0.5648 0.5214 1086 SPBio_000982 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(c1)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B05 compound treatment 239200.0 152000.0 1.29 117520.0 -20200.0 -0.17 0.7949 0.6106 1221 SPBio_000983 CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B06 compound treatment 258400.0 171000.0 1.45 133880.0 -3820.0 -0.03 1.0062 0.6916 1184 SPBio_000984 Nc1ncnc2n(cnc12)C3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B07 compound treatment 187200.0 99600.0 0.85 33880.0 -104000.0 -0.86 -0.0074 -0.0062 1058 SPBio_000985 C[C@@]12CCC3C(CCC4=Cc5oncc5C[C@]34C)C2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B08 compound treatment 259920.0 172000.0 1.47 62520.0 -75200.0 -0.62 0.5979 0.3751 1434 SPBio_000986 CN1CCN2C(C1)c3ccccc3Cc4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B09 compound treatment 219400.0 132000.0 1.12 54080.0 -83600.0 -0.69 0.3046 0.231 1302 SPBio_000987 CC(C)CC1N2C(=O)[C@](NC(=O)C3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(OC2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B10 compound treatment 255960.0 168000.0 1.43 89960.0 -47700.0 -0.39 0.7346 0.4939 965 SPBio_000988 C(C1=NCCN1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B11 compound treatment 134120.0 46600.0 0.4 70200.0 -67500.0 -0.56 -0.1146 -0.1673 2060103 SPBio_000989 COc1ccc2C(=O)[C@@H]3[C@@H](COc4cc(OC)c(OC)cc34)Oc2c1CC=C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B12 compound treatment 258640.0 171000.0 1.46 195760.0 58100.0 0.48 1.3696 0.893 865 SPBio_000990 Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B13 compound treatment 250960.0 163000.0 1.39 196720.0 59000.0 0.49 1.329 0.9014 3045298 SPBio_000991 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B14 compound treatment 230160.0 143000.0 1.21 110920.0 -26800.0 -0.22 0.7019 0.5687 1487 SPBio_000992 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B15 compound treatment 257800.0 170000.0 1.45 76320.0 -61400.0 -0.51 0.6659 0.4336 1412 SPBio_000993 CN(C)CCOC(c1ccc(Cl)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B16 compound treatment 273520.0 186000.0 1.58 77000.0 -60700.0 -0.5 0.7645 0.4603 1322 SPBio_000994 COc1cc2ccc(=O)oc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B17 compound treatment 244040.0 156000.0 1.33 65960.0 -71700.0 -0.59 0.5224 0.3582 3198425 SPBio_000995 CC1(C)O[C@@H]2CO[C@@]3(COS(=O)(=O)N)OC(C)(C)O[C@H]3[C@@H]2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B18 compound treatment 212120.0 125000.0 1.06 68160.0 -69500.0 -0.58 0.3431 0.2844 1227 SPBio_000996 NCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B19 compound treatment 260280.0 173000.0 1.47 87000.0 -50700.0 -0.42 0.7433 0.4861 775 SPBio_000997 NCC(O)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B20 compound treatment 261320.0 174000.0 1.48 90400.0 -47300.0 -0.39 0.7694 0.5028 142 SPBio_000998 CCOC(=O)C(C)(C)Oc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B21 compound treatment 88680.0 1110.0 0.01 56560.0 -81100.0 -0.67 -0.4679 -0.697 2069268 SPBio_000999 CC(=O)O[C@H]1CC[C@]2(C)C3CC[C@@]4(C)C(CCC4=O)C3CC=C2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B22 compound treatment 207840.0 120000.0 1.02 119600.0 -18100.0 -0.15 0.6183 0.5974 198 SPBio_001000 CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B23 mock treatment 202120.0 115000.0 0.98 155800.0 18100.0 0.15 0.7956 0.8062 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 B24 mock treatment 76960.0 -10600.0 -0.09 135920.0 -1780.0 -0.01 -0.0742 -0.8115 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C01 mock treatment 122600.0 35000.0 0.3 137880.0 183.0 0.0 0.212 0.7107 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C02 mock treatment 189000.0 101000.0 0.86 129120.0 -8580.0 -0.07 0.5605 0.6468 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C03 compound treatment 54280.0 -33300.0 -0.28 38160.0 -99500.0 -0.82 -0.7827 -0.8987 1370 SPBio_001001 C/C=C(/C(=C/C)/c1ccc(O)cc1)\c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C04 compound treatment 200240.0 113000.0 0.96 104120.0 -33600.0 -0.28 0.4819 0.4825 888 SPBio_001002 CC(C)[N+](C)(CCC(C(=O)N)(c1ccccc1)c2ccccc2)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C05 compound treatment 194200.0 107000.0 0.91 88160.0 -49500.0 -0.41 0.3522 0.3536 1301 SPBio_001003 OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C06 compound treatment 253920.0 166000.0 1.42 135080.0 -2620.0 -0.02 0.9862 0.6962 1362 SPBio_001004 COc1c2occc2cc3ccc(=O)oc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C07 compound treatment 101040.0 13500.0 0.11 19840.0 -118000.0 -0.97 -0.6083 -0.6196 1468 SPBio_001005 CCCCC(=O)O[C@H]1CCC2C3CCc4cc(O)ccc4C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C08 compound treatment 263800.0 176000.0 1.5 70680.0 -67000.0 -0.55 0.669 0.4182 82 SPBio_001006 Nc1cc(nc(N)[n+]1[O-])N2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C09 compound treatment 254200.0 167000.0 1.42 77840.0 -59900.0 -0.5 0.6531 0.4346 3177451 SPBio_001007 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C10 compound treatment 267720.0 180000.0 1.53 86480.0 -51200.0 -0.42 0.785 0.4933 1083 SPBio_001008 C(C1=NCCN1)c2cccc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C11 compound treatment 240360.0 153000.0 1.3 65280.0 -72400.0 -0.6 0.4963 0.3465 793 SPBio_001009 CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C12 compound treatment 270160.0 183000.0 1.55 234320.0 96600.0 0.8 1.6645 0.9522 953 SPBio_001010 C[C@H](N)[C@H](O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C13 compound treatment 282640.0 195000.0 1.66 201800.0 64100.0 0.53 1.5494 0.8887 826 SPBio_001011 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)CC[C@]5(C)C4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C14 compound treatment 269600.0 182000.0 1.55 119360.0 -18300.0 -0.15 0.9887 0.6349 1000108 SPBio_001012 NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C15 compound treatment 260440.0 173000.0 1.47 76640.0 -61100.0 -0.51 0.6836 0.4393 905 SPBio_001013 CO[C@@H]1[C@@H](OC(=O)N)[C@@H](O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C16 compound treatment 240840.0 153000.0 1.31 71080.0 -66600.0 -0.55 0.5331 0.3763 3173081 SPBio_001014 COCCc1ccc(OCC(O)CNC(C)C)cc1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C17 compound treatment 221640.0 134000.0 1.14 59120.0 -78600.0 -0.65 0.3475 0.2646 959 SPBio_001015 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C18 compound treatment 205920.0 118000.0 1.01 73280.0 -64400.0 -0.53 0.3357 0.2945 110 SPBio_001016 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C19 compound treatment 238760.0 151000.0 1.29 105680.0 -32000.0 -0.26 0.723 0.5501 700 SPBio_001017 CN1C2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C20 compound treatment 244160.0 157000.0 1.33 111720.0 -26000.0 -0.21 0.7908 0.5856 3177386 SPBio_001018 NC[C@H]1O[C@H](OC2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C21 compound treatment 217880.0 130000.0 1.11 99640.0 -38100.0 -0.31 0.5619 0.4872 1127 SPBio_001019 CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C22 compound treatment 184120.0 96600.0 0.82 97200.0 -40500.0 -0.34 0.3444 0.388 1508 SPBio_001020 CSCCC(NC=O)C(=O)NC(C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C23 mock treatment 147920.0 60400.0 0.51 113160.0 -24500.0 -0.2 0.2198 0.3979 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 C24 mock treatment 29680.0 -57900.0 -0.49 139880.0 2180.0 0.02 -0.3357 -0.6807 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D01 mock treatment 117360.0 29800.0 0.25 76640.0 -61100.0 -0.51 -0.1778 -0.3145 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D02 mock treatment 137960.0 50400.0 0.43 86840.0 -50900.0 -0.42 0.0059 0.0098 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D03 compound treatment 13760.0 -73800.0 -0.63 9640.0 -128000.0 -1.06 -1.1934 -0.9689 820 SPBio_001021 Oc1ccc(Cl)c2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D04 compound treatment 234680.0 147000.0 1.25 137360.0 -337.0 0.0 0.8837 0.7055 861 SPBio_001022 C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D05 compound treatment 260040.0 172000.0 1.47 175280.0 37600.0 0.31 1.2582 0.8382 1451 SPBio_001023 CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D06 compound treatment 257600.0 170000.0 1.45 136520.0 -1180.0 -0.01 1.0168 0.7023 3055445 SPBio_001024 CC(=O)OC(C)(C)[C@@H]1Cc2cc3ccc(=O)oc3cc2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D07 compound treatment 264600.0 177000.0 1.51 101920.0 -35800.0 -0.3 0.8566 0.5576 1186 SPBio_001025 Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D08 compound treatment 311000.0 223000.0 1.9 138680.0 983.0 0.01 1.3509 0.7101 3172849 SPBio_001026 CN1CCC[C@H]1c2cccnc2.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D09 compound treatment 264400.0 177000.0 1.51 108480.0 -29200.0 -0.24 0.8937 0.5861 2060478 SPBio_001027 CNc1ccc(cc1)C(=O)CC(O)CCC(C)C2OC(=O)CC(O)CC(=O)CC(O)CC(O)CC(O)CC(O)CC3(O)CC(O)C(C(CC(O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/C2C)O3)C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D10 compound treatment 26520.0 -61000.0 -0.52 13240.0 -124000.0 -1.03 -1.0956 -0.9499 1087 SPBio_001028 Oc1ccc(Cl)cc1Cc2cc(Cl)ccc2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D11 compound treatment 236640.0 149000.0 1.27 142600.0 4900.0 0.04 0.9262 0.7293 4480 SPBio_001029 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D12 compound treatment 280640.0 193000.0 1.64 234760.0 97100.0 0.8 1.7302 0.9457 1190 SPBio_001030 Nc1c2C(O)CCCc2nc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D13 compound treatment 262880.0 175000.0 1.49 220480.0 82800.0 0.68 1.5397 0.9376 682 SPBio_001031 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3C(=O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D14 compound treatment 252320.0 165000.0 1.4 149400.0 11700.0 0.1 1.0604 0.7541 1448 SPBio_001032 OC(=O)c1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D15 compound treatment 256920.0 169000.0 1.44 100120.0 -37600.0 -0.31 0.7998 0.5422 1446 SPBio_001033 OC(COc1cccc2oc(cc(=O)c12)C(=O)O)COc3cccc4oc(cc(=O)c34)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D16 compound treatment 254320.0 167000.0 1.42 79160.0 -58500.0 -0.48 0.6615 0.441 705 SPBio_001034 CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D17 compound treatment 277200.0 190000.0 1.61 93040.0 -44700.0 -0.37 0.8805 0.5316 2069333 SPBio_001035 CC[C@H](/C=C/C(C)C1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D18 compound treatment 228440.0 141000.0 1.2 62960.0 -74700.0 -0.62 0.4109 0.3045 1577 SPBio_001036 OCC(S)CS 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D19 compound treatment 53280.0 -34300.0 -0.29 39960.0 -97700.0 -0.81 -0.7781 -0.9052 1088 SPBio_001037 CCN(CC)CCOc1ccc(cc1)/C(=C(\Cl)/c2ccccc2)/c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D20 compound treatment 214880.0 127000.0 1.08 76680.0 -61000.0 -0.5 0.4096 0.3425 3177322 SPBio_001038 CC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D21 compound treatment 225000.0 137000.0 1.17 109120.0 -28600.0 -0.24 0.6603 0.5531 689 SPBio_001039 Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C(=O)O)s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D22 compound treatment 13640.0 -73900.0 -0.63 9280.0 -128000.0 -1.06 -1.1963 -0.9688 3174103 SPBio_001040 C/C/1=C\CC[C@@]2(C)OC2[C@H]3OC(=O)C(=C)[C@@H]3CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D23 mock treatment 144720.0 57200.0 0.49 102400.0 -35300.0 -0.29 0.1376 0.2425 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 D24 mock treatment 45240.0 -42300.0 -0.36 90200.0 -47500.0 -0.39 -0.5327 -0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E01 mock treatment 183720.0 96200.0 0.82 46960.0 -90700.0 -0.75 0.0481 0.0433 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E02 mock treatment 128280.0 40700.0 0.35 70640.0 -67100.0 -0.55 -0.1471 -0.2249 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E03 compound treatment 204240.0 117000.0 0.99 141920.0 4220.0 0.03 0.7271 0.7315 1265 SPBio_001041 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4c(Cl)cccc4Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E04 compound treatment 229240.0 142000.0 1.21 177440.0 39700.0 0.33 1.0854 0.8682 1479 SPBio_001042 CC(C)NCC(O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E05 compound treatment 251000.0 163000.0 1.39 174760.0 37100.0 0.31 1.2008 0.8427 1441 SPBio_001043 CN1CCC(CC1)OC(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E06 compound treatment 256960.0 169000.0 1.44 207960.0 70300.0 0.58 1.4309 0.9202 1009 SPBio_001044 C[N+]1(C)C2CC(CC1C3OC32)OC(=O)[C@@H](CO)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E07 compound treatment 222920.0 135000.0 1.15 125360.0 -12300.0 -0.1 0.7427 0.642 1363 SPBio_001045 CCOC(=O)CCC(=O)O[C@@H]1[C@H](C[C@@H](C)O[C@H]1O[C@@H]2[C@@H](C)[C@H](O[C@H]3C[C@@](C)(OC)[C@@H](O)[C@H](C)O3)[C@@H](C)C(=O)O[C@H](CC)[C@@](C)(O)[C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@]2(C)O)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E08 compound treatment 269520.0 182000.0 1.55 130800.0 -6900.0 -0.06 1.0551 0.6806 1000107 SPBio_001046 CC(=O)O[C@]1(CCC2C3CCC4=CC(=O)CC[C@@H]4C3CC[C@@]21C)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E09 compound treatment 196920.0 109000.0 0.93 111720.0 -26000.0 -0.21 0.5064 0.53 727 SPBio_001047 CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E10 compound treatment 311760.0 224000.0 1.91 201600.0 63900.0 0.53 1.7236 0.8702 879 SPBio_001048 NC[C@H](O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E11 compound treatment 350400.0 263000.0 2.24 207760.0 70100.0 0.58 1.9922 0.8618 1222 SPBio_001049 Cn1cnc2n(C)c(=O)[nH]c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E12 compound treatment 266280.0 179000.0 1.52 231560.0 93900.0 0.78 1.625 0.9512 3173462 SPBio_001050 C[C@H](COc1ccccc1)N[C@@H](C)[C@H](O)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E13 compound treatment 288920.0 201000.0 1.71 239120.0 101000.0 0.84 1.8056 0.946 706 SPBio_001051 Nc1ccc(cc1)S(=O)(=O)Nc2cnc3ccccc3n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E14 compound treatment 284560.0 197000.0 1.68 164520.0 26800.0 0.22 1.3429 0.7937 1169 SPBio_001052 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@H]34)C2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E15 compound treatment 282560.0 195000.0 1.66 184200.0 46500.0 0.38 1.446 0.8485 3177388 SPBio_001053 COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E16 compound treatment 285440.0 198000.0 1.68 149160.0 11500.0 0.09 1.2584 0.7457 1000139 SPBio_001054 CO[C@]1(NC(=O)C(C(=O)O)c2ccc(O)cc2)[C@H]3OCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E17 compound treatment 281680.0 194000.0 1.65 131320.0 -6380.0 -0.05 1.1314 0.6842 876 SPBio_001055 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E18 compound treatment 229240.0 142000.0 1.21 113280.0 -24400.0 -0.2 0.7101 0.5806 800 SPBio_001056 C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E19 compound treatment 229520.0 142000.0 1.21 139600.0 1900.0 0.02 0.8658 0.7163 756 SPBio_001057 CCCCCCc1ccc(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E20 compound treatment 392720.0 305000.0 2.6 166160.0 28500.0 0.24 2.0037 0.768 1064 SPBio_001058 [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E21 compound treatment 204040.0 116000.0 0.99 127400.0 -10300.0 -0.09 0.641 0.644 1174 SPBio_001059 CN(C)CCCN1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E22 compound treatment 196800.0 109000.0 0.93 92080.0 -45600.0 -0.38 0.3908 0.3894 2935 SPBio_001060 CC(=O)NCc1c(I)c(NC(=O)C)c(I)c(C(=O)O)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E23 mock treatment 151560.0 64000.0 0.54 121520.0 -16200.0 -0.13 0.2906 0.518 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 E24 mock treatment 45000.0 -42600.0 -0.36 90360.0 -47300.0 -0.39 -0.5332 -0.9993 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F01 mock treatment 157760.0 70200.0 0.6 66200.0 -71500.0 -0.59 0.0044 0.0052 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F02 mock treatment 134440.0 46900.0 0.4 79720.0 -58000.0 -0.48 -0.0569 -0.0913 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F03 compound treatment 174200.0 86600.0 0.74 115200.0 -22500.0 -0.19 0.39 0.5126 1114 SPBio_001061 NS(=O)(=O)c1cc2c(N=C(CSCc3ccccc3)NS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F04 compound treatment 210600.0 123000.0 1.05 163200.0 25500.0 0.21 0.8899 0.8328 957 SPBio_001062 NC(COC(=O)C=[N+]=[N-])C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F05 compound treatment 228120.0 141000.0 1.2 191400.0 53700.0 0.44 1.1604 0.909 1001638 SPBio_001063 CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F06 compound treatment 248400.0 161000.0 1.37 135840.0 -1860.0 -0.02 0.9574 0.6991 3054072 SPBio_001064 OC(=O)CCCCCCCCCCCCC1CCC=C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F07 compound treatment 267880.0 180000.0 1.54 212920.0 75200.0 0.62 1.5256 0.9209 1337 SPBio_001065 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F08 compound treatment 237600.0 150000.0 1.28 135000.0 -2700.0 -0.02 0.8875 0.6947 1020088 SPBio_001066 NNCc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F09 compound treatment 273280.0 186000.0 1.58 207880.0 70200.0 0.58 1.5286 0.9075 3173625 SPBio_001067 Nc1nc2n(cnc2c(=O)[nH]1)C3C[C@H](O)[C@@H](CO)O3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F10 compound treatment 276960.0 189000.0 1.61 186880.0 49200.0 0.41 1.428 0.8586 2508 SPBio_001068 OC(=O)COc1cc(Cl)c(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F11 compound treatment 234640.0 147000.0 1.25 130640.0 -7060.0 -0.06 0.8442 0.6734 1031842 SPBio_001069 CC(=O)Oc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F12 compound treatment 279600.0 192000.0 1.64 276400.0 139000.0 1.15 1.9675 0.985 2477 SPBio_001070 CCOP(=S)(OCC)SCSP(=S)(OCC)OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F13 compound treatment 285880.0 198000.0 1.69 328800.0 191000.0 1.58 2.3118 0.9995 894 SPBio_001071 ClCCN(CCCl)P1(=O)NCCCO1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F14 compound treatment 278600.0 191000.0 1.63 196360.0 58700.0 0.49 1.4933 0.8798 2476 SPBio_001072 CCOP(=S)(OCC)Oc1cc(C)nc(n1)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F15 compound treatment 276280.0 189000.0 1.61 250160.0 112000.0 0.93 1.794 0.9663 1125 SPBio_001073 CCOC(=O)NNc1nncc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F16 compound treatment 244120.0 157000.0 1.33 179560.0 41900.0 0.35 1.1874 0.8622 2484 SPBio_001074 COP(=O)(OC)OC=C(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F17 compound treatment 271440.0 184000.0 1.57 189920.0 52200.0 0.43 1.4125 0.8697 964 SPBio_001075 CN(C)N=Nc1[nH]cnc1C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F18 compound treatment 267400.0 180000.0 1.53 213040.0 75300.0 0.62 1.5234 0.9215 2487 SPBio_001076 CCOC(=O)CC(SP(=S)(OC)OC)C(=O)OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F19 compound treatment 237520.0 150000.0 1.28 223800.0 86100.0 0.71 1.4065 0.962 1480 SPBio_001077 Clc1ccc2oc(=O)[nH]c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F20 compound treatment 240240.0 153000.0 1.3 207600.0 69900.0 0.58 1.3281 0.9335 2496 SPBio_001078 CN(C)C(=O)Nc1ccc(Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F21 compound treatment 225440.0 138000.0 1.17 193080.0 55400.0 0.46 1.154 0.9158 2060468 SPBio_001079 CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F22 compound treatment 191200.0 104000.0 0.88 131520.0 -6180.0 -0.05 0.5878 0.665 2523 SPBio_001080 CCOP(=S)(OCC)Oc1nc(Cl)c(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F23 mock treatment 153960.0 66400.0 0.57 144280.0 6580.0 0.05 0.4382 0.7717 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 F24 mock treatment 36080.0 -51500.0 -0.44 72160.0 -65500.0 -0.54 -0.6933 -0.9944 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G01 mock treatment 112480.0 24900.0 0.21 107880.0 -29800.0 -0.25 -0.0244 -0.0751 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G02 mock treatment 119160.0 31600.0 0.27 86000.0 -51700.0 -0.43 -0.1122 -0.2221 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G03 compound treatment 123800.0 36200.0 0.31 119000.0 -18700.0 -0.15 0.1088 0.3152 915 SPBio_001081 OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G04 compound treatment 175000.0 87400.0 0.74 137640.0 -56.9 0.0 0.5261 0.7067 2060472 SPBio_001082 C[C@@]12CCC3C(C=CC4=CC(=O)CC[C@]34C)C2CC[C@@]1(O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G05 compound treatment 229720.0 142000.0 1.21 221960.0 84300.0 0.7 1.3488 0.9657 3173092 SPBio_001083 CN(C)CCOC(c1ccccc1)c2ccccc2.Cn1c(=O)n(C)c2nc(Cl)[nH]c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G06 compound treatment 285200.0 198000.0 1.68 223080.0 85400.0 0.71 1.6893 0.9257 815 SPBio_001084 CCN(CC)C(=O)c1cccc(C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G07 compound treatment 204640.0 117000.0 1.0 170640.0 32900.0 0.27 0.8976 0.8686 3174481 SPBio_001085 CNC[C@@H](O)c1ccc(O)c(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G08 compound treatment 163280.0 75700.0 0.64 107760.0 -29900.0 -0.25 0.2807 0.4065 772 SPBio_001086 CCN1CCCC(C1)OC(=O)C(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G09 compound treatment 296520.0 209000.0 1.78 238400.0 101000.0 0.83 1.8471 0.9402 803 SPBio_001087 CCc1cc(ccn1)C(=S)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G10 compound treatment 311160.0 224000.0 1.9 231560.0 93900.0 0.78 1.8952 0.9218 904 SPBio_001088 NC(=O)CN1CCCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G11 compound treatment 287760.0 200000.0 1.7 264960.0 127000.0 1.05 1.9497 0.9732 1150 SPBio_001089 OC(=O)CCCCCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G12 compound treatment 272960.0 185000.0 1.58 305520.0 168000.0 1.39 2.0979 0.998 1111 SPBio_001090 CCC(C)C1NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(CCNC(=O)C(NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(NC1=O)C(C)CC)C(C)O)NC(=O)C(CCNCS(=O)(=O)O)NC(=O)C(NC(=O)C(CCNCS(=O)(=O)O)NC(=O)CCCCC(C)C)C(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G13 compound treatment 273640.0 186000.0 1.58 290160.0 152000.0 1.26 2.0121 0.9936 790 SPBio_001091 COc1ccc2[C@@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G14 compound treatment 27360.0 -60200.0 -0.51 26960.0 -111000.0 -0.92 -1.0102 -0.9624 1000054 SPBio_001092 CC(C)CC1NC(=O)C(CCCN)NC(=O)C(NC(=O)C2CCCN2C(=O)C(Cc3ccccc3)NC(=O)C(CC(C)C)NC(=O)C(CCCN)NC(=O)C(NC(=O)C4CCCN4C(=O)C(Cc5ccccc5)NC1=O)C(C)C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G15 compound treatment 228280.0 141000.0 1.2 195240.0 57500.0 0.48 1.1838 0.9182 809 SPBio_001093 CNCCC=C1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G16 compound treatment 130360.0 42800.0 0.36 204120.0 66400.0 0.55 0.6462 0.9801 464 SPBio_001094 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G17 compound treatment 241520.0 154000.0 1.31 188280.0 50600.0 0.42 1.2228 0.8887 1181 SPBio_001095 Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G18 compound treatment 262720.0 175000.0 1.49 211760.0 74100.0 0.61 1.4878 0.9228 1257 SPBio_001096 CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G19 compound treatment 266680.0 179000.0 1.53 230800.0 93100.0 0.77 1.623 0.95 948 SPBio_001097 O=C1C(C(=O)c2ccccc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G20 compound treatment 140440.0 52900.0 0.45 123040.0 -14700.0 -0.12 0.2326 0.4989 3046211 SPBio_001098 CCC(C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C/C=C(\C)/[C@@H](OC4C[C@H](OC)C(O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2)C=C[C@@H]1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G21 compound treatment 140320.0 52800.0 0.45 115480.0 -22200.0 -0.18 0.1876 0.3866 3174102 SPBio_001099 OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G22 compound treatment 198920.0 111000.0 0.95 200480.0 62800.0 0.52 1.0377 0.9599 900 SPBio_001100 CN1C(=C(O)c2sccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G23 mock treatment 138320.0 50800.0 0.43 154240.0 16500.0 0.14 0.4023 0.8876 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 G24 mock treatment 35440.0 -52100.0 -0.44 76680.0 -61000.0 -0.5 -0.6708 -0.9979 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H01 mock treatment 49520.0 -38000.0 -0.32 148480.0 10800.0 0.09 -0.166 -0.494 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H02 mock treatment 94480.0 6910.0 0.06 117080.0 -20600.0 -0.17 -0.079 -0.4377 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H03 compound treatment 148520.0 61000.0 0.52 132400.0 -5300.0 -0.04 0.336 0.6451 1104 SPBio_001101 C[C@H](CCC(=O)O)[C@H]1CCC2C3C(CC(=O)[C@]12C)[C@@]4(C)CCC(=O)CC4CC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H04 compound treatment 158240.0 70700.0 0.6 138520.0 823.0 0.01 0.4303 0.7151 2529 SPBio_001102 COP(=S)(OC)Oc1ccc(SC)c(C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H05 compound treatment 261400.0 174000.0 1.48 234440.0 96700.0 0.8 1.6125 0.9583 1430 SPBio_001103 CCC(=O)OCC(=O)C1(OC(=O)CC)C(C)CC2C3CCC4=CC(=O)C=CC4(C)C3(Cl)C(O)CC21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H06 compound treatment 247680.0 160000.0 1.36 225600.0 87900.0 0.73 1.4782 0.9567 2531 SPBio_001104 CNC(=O)Oc1ccccc1OC(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H07 compound treatment 228640.0 141000.0 1.2 249720.0 112000.0 0.93 1.5046 0.9918 1409 SPBio_001105 CCCC(C)(COC(=O)N)COC(=O)NC(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H08 compound treatment 135880.0 48300.0 0.41 102840.0 -34900.0 -0.29 0.087 0.1731 2533 SPBio_001106 Clc1ccc(cc1)C(c2ccc(Cl)cc2)C(Cl)(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H09 compound treatment 248320.0 161000.0 1.37 330640.0 193000.0 1.6 2.0965 0.9971 1587 SPBio_001107 NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@@H]4O[C@H](CO)[C@@H](O)C[C@H]4N)O[C@@H]2CO)[C@H](N)[C@@H](O)[C@@H]1O[C@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]5O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H10 compound treatment 248280.0 161000.0 1.37 278880.0 141000.0 1.17 1.7935 0.9969 3177463 SPBio_001108 CC1=C(N2C(SC1)[C@H](NC(=O)[C@H](N)C3=CCC=CC3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H11 compound treatment 185120.0 97600.0 0.83 187760.0 50100.0 0.41 0.8802 0.9483 745 SPBio_001109 CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H12 compound treatment 276960.0 189000.0 1.61 305720.0 168000.0 1.39 2.1231 0.9973 835 SPBio_001110 CC(=O)OC1CN2CCC1CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H13 compound treatment 220360.0 133000.0 1.13 238880.0 101000.0 0.84 1.3914 0.9891 436 SPBio_001111 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H14 compound treatment 232880.0 145000.0 1.24 262480.0 125000.0 1.03 1.6048 0.9959 4164 SPBio_001112 CC(C(=O)O)c1ccc2c(c1)[nH]c3ccc(Cl)cc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H15 compound treatment 214080.0 127000.0 1.08 275960.0 138000.0 1.14 1.5705 0.9996 1575 SPBio_001113 CNC1=Nc2ccc(Cl)cc2C(=[N+]([O-])C1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H16 compound treatment 157720.0 70200.0 0.6 219760.0 82100.0 0.68 0.9024 0.998 2060327 SPBio_001114 COc1cc2CCN(C)[C@H]3Oc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c32)cc7)N(C)CCc6cc5OC)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H17 compound treatment 39200.0 -48400.0 -0.41 69560.0 -68100.0 -0.56 -0.6898 -0.9881 3055248 SPBio_001115 C=CC(C1=CC(=O)C=CC1=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H18 compound treatment 189560.0 102000.0 0.87 202920.0 65200.0 0.54 0.9956 0.9738 1522 SPBio_001116 CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H19 compound treatment 257120.0 170000.0 1.44 267800.0 130000.0 1.08 1.7819 0.9895 729 SPBio_001117 OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@@H]2O[C@H](CO)[C@H](O)[C@H](O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H20 compound treatment 35600.0 -52000.0 -0.44 37600.0 -100000.0 -0.83 -0.8984 -0.9569 3177316 SPBio_001118 C[C@@H]1O[C@@H](O[C@H]2CC[C@]3(C=O)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H21 compound treatment 213400.0 126000.0 1.07 239400.0 102000.0 0.84 1.3525 0.9928 1113841 SPBio_001119 Oc1ccc2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H22 compound treatment 74560.0 -13000.0 -0.11 72840.0 -64900.0 -0.54 -0.4577 -0.8354 3063989 SPBio_001120 C[C@H]1[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@@]42OC(=O)O/C=C/[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]4[C@@H]5O[C@@]51C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H23 mock treatment 139760.0 52200.0 0.44 129040.0 -8660.0 -0.07 0.2636 0.5856 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 H24 mock treatment 26080.0 -61500.0 -0.52 101600.0 -36100.0 -0.3 -0.5813 -0.9646 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I01 mock treatment 45480.0 -42100.0 -0.36 142000.0 4300.0 0.04 -0.2282 -0.6337 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I02 mock treatment 113480.0 25900.0 0.22 123040.0 -14700.0 -0.12 0.0703 0.2791 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I03 compound treatment 91960.0 4390.0 0.04 96440.0 -41300.0 -0.34 -0.2149 -0.6258 969 SPBio_001121 CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I04 compound treatment 103440.0 15900.0 0.14 108560.0 -29100.0 -0.24 -0.0749 -0.2709 2558 SPBio_001122 c1ccc2c(c1)cc3ccc4cccc5ccc2c3c45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I05 compound treatment 234440.0 147000.0 1.25 234120.0 96400.0 0.8 1.4483 0.9764 3174228 SPBio_001123 CN[C@H]1C(O)C(O)C(CO)OC1OC2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)OC(C)[C@]2(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I06 compound treatment 234320.0 147000.0 1.25 241840.0 104000.0 0.86 1.4927 0.9835 1009654 SPBio_001124 COc1ccc(cc1OC)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I07 compound treatment 71760.0 -15800.0 -0.13 97200.0 -40500.0 -0.34 -0.3321 -0.9197 1224 SPBio_001125 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@H]1OC(=O)CCC5CCCC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I08 compound treatment 215400.0 128000.0 1.09 242320.0 105000.0 0.87 1.3816 0.9936 1012 SPBio_001126 Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I09 compound treatment 151960.0 64400.0 0.55 185320.0 47600.0 0.39 0.6663 0.9869 1139 SPBio_001127 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I10 compound treatment 40400.0 -47200.0 -0.4 47920.0 -89800.0 -0.74 -0.8091 -0.9583 3172974 SPBio_001128 C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)C4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)C4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I11 compound treatment 239720.0 152000.0 1.3 299520.0 162000.0 1.34 1.8627 0.9999 1188 SPBio_001129 NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I12 compound treatment 263920.0 176000.0 1.5 281280.0 144000.0 1.19 1.9017 0.9933 1206 SPBio_001130 CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)O[C@H]2[C@@]53C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I13 compound treatment 192520.0 105000.0 0.89 213720.0 76000.0 0.63 1.0766 0.9852 1215 SPBio_001131 CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I14 compound treatment 244320.0 157000.0 1.33 271520.0 134000.0 1.11 1.7266 0.9957 3078331 SPBio_001132 OC(=O)c1cccc(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I15 compound treatment 192520.0 105000.0 0.89 235440.0 97700.0 0.81 1.2036 0.9988 1219 SPBio_001133 CC[C@@]12CCC3C(CCC4=CC(=O)CC[C@H]34)C2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I16 compound treatment 48560.0 -39000.0 -0.33 68600.0 -69100.0 -0.57 -0.639 -0.9666 810 SPBio_001134 CCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I17 compound treatment 172920.0 85400.0 0.73 260720.0 123000.0 1.02 1.2335 0.9864 838 SPBio_001135 COc1ccc(C(=O)c2ccccc2)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I18 compound treatment 17280.0 -70300.0 -0.6 21840.0 -116000.0 -0.96 -1.1009 -0.9743 704 SPBio_001136 CN(C)c1ccc(cc1)C(=C2C=CC(=[N+](C)C)C=C2)c3ccc(cc3)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I19 compound treatment 251560.0 164000.0 1.4 267840.0 130000.0 1.08 1.7486 0.9917 3273 SPBio_001137 NNCCc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I20 compound treatment 215080.0 128000.0 1.09 183600.0 45900.0 0.38 1.0362 0.9009 1585 SPBio_001138 CC(C)c1ccc(C)c2ccc(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I21 compound treatment 193400.0 106000.0 0.9 220600.0 82900.0 0.69 1.1221 0.9909 1131 SPBio_001139 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I22 compound treatment 89440.0 1870.0 0.02 106120.0 -31600.0 -0.26 -0.1734 -0.6627 1000377 SPBio_001140 CC(C)c1nc(nc(c1/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c2ccc(F)cc2)N(C)S(=O)(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I23 mock treatment 105440.0 17900.0 0.15 172760.0 35100.0 0.29 0.3127 0.9547 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 I24 mock treatment 24040.0 -63500.0 -0.54 111680.0 -26000.0 -0.22 -0.5346 -0.9184 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J01 mock treatment 41200.0 -46400.0 -0.39 198600.0 60900.0 0.5 0.0771 0.1205 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J02 mock treatment 84040.0 -3530.0 -0.03 156000.0 18300.0 0.15 0.0858 0.5561 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J03 compound treatment 155080.0 67500.0 0.57 207440.0 69700.0 0.58 0.8144 1.0 1000134 SPBio_001141 Nc1ccn(C2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J04 compound treatment 177640.0 90100.0 0.77 203160.0 65500.0 0.54 0.9252 0.9855 1000093 SPBio_001142 CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J05 compound treatment 200160.0 113000.0 0.96 172920.0 35200.0 0.29 0.8839 0.8822 1113 SPBio_001143 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(=O)O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J06 compound treatment 200120.0 113000.0 0.96 223520.0 85800.0 0.71 1.1797 0.9891 2141064 SPBio_001144 COC1=C[C@@H]2[C@@H]3Cc4ccc(OC)c(O)c4[C@]2(CCN3C)CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J07 compound treatment 67080.0 -20500.0 -0.17 112520.0 -25200.0 -0.21 -0.2706 -0.9961 3055370 SPBio_001145 COC(=O)c1c(C)c2Oc3c(Cl)c(OC(=O)C)c(Cl)c(C)c3C(=O)Oc2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J08 compound treatment 15080.0 -72500.0 -0.62 35160.0 -103000.0 -0.85 -1.0362 -0.9878 3079387 SPBio_001146 CN(/C=N/c1ccc(C)cc1C)/C=N/c2ccc(C)cc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J09 compound treatment 71040.0 -16500.0 -0.14 106520.0 -31200.0 -0.26 -0.2819 -0.9594 2069224 SPBio_001147 COc1ccc(cc1)c2c(O)c3cc4CCC(C)(C)Oc4c(CC=C(C)C)c3oc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J10 compound treatment 231640.0 144000.0 1.23 280680.0 143000.0 1.18 1.7038 0.9998 3177525 SPBio_001148 NCCCC(N)C(=O)O.OC(=O)CCC(=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J11 compound treatment 234680.0 147000.0 1.25 299520.0 162000.0 1.34 1.8323 0.9994 2060359 SPBio_001149 COc1ccc(cc1)c2c(O)c3c(OC)c4C=CC(C)(C)Oc4cc3oc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J12 compound treatment 103760.0 16200.0 0.14 140360.0 2660.0 0.02 0.1131 0.8098 885 SPBio_001150 Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J13 compound treatment 15000.0 -72600.0 -0.62 22200.0 -115000.0 -0.96 -1.1125 -0.9777 2060346 SPBio_001151 CC(=O)Oc1cc2c(CC=C3[C@@]2(C)CC[C@@]4(C)C5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O)c(C)c1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J14 compound treatment 35680.0 -51900.0 -0.44 51760.0 -85900.0 -0.71 -0.8151 -0.9738 3046390 SPBio_001152 CCC(=O)O[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J15 compound treatment 118320.0 30800.0 0.26 173680.0 36000.0 0.3 0.3956 0.998 2060444 SPBio_001153 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J16 compound treatment 17840.0 -69700.0 -0.59 26040.0 -112000.0 -0.92 -1.0729 -0.9772 3198427 SPBio_001154 CCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J17 compound treatment 190520.0 103000.0 0.88 275400.0 138000.0 1.14 1.4254 0.9916 2060377 SPBio_001155 COc1c(ccc2OC(C)(C)CCc12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J18 compound treatment 195320.0 108000.0 0.92 271280.0 134000.0 1.11 1.4302 0.9957 1072288 SPBio_001156 CC(=C)C1CNC(C1CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J19 compound treatment 209280.0 122000.0 1.04 267440.0 130000.0 1.07 1.4917 0.9998 2060190 SPBio_001157 C[C@H]1[C@H]2[C@H](CC3C4CC[C@H]5C[C@H](CC[C@]5(C)C4C(=O)[C@@H](OC(=O)C)[C@]23C)OC(=O)C)O[C@@]61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J20 compound treatment 189320.0 102000.0 0.87 270280.0 133000.0 1.1 1.3882 0.9932 3198428 SPBio_001158 CCOC(=O)[C@H](CCc1ccccc1)N[C@H](C)C(=O)N2[C@@H](CC3CCCCC32)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J21 compound treatment 131040.0 43500.0 0.37 222720.0 85000.0 0.7 0.7591 0.9551 1312 SPBio_001159 C[As](=O)(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J22 compound treatment 92760.0 5190.0 0.04 117800.0 -19900.0 -0.16 -0.0851 -0.4994 1078453 SPBio_001160 Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J23 mock treatment 115120.0 27600.0 0.23 190160.0 52500.0 0.43 0.4728 0.9583 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 J24 mock treatment 44040.0 -43500.0 -0.37 158560.0 20900.0 0.17 -0.14 -0.3425 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K01 mock treatment 40280.0 -47300.0 -0.4 197000.0 59300.0 0.49 0.0622 0.098 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K02 mock treatment 79720.0 -7850.0 -0.07 170920.0 33200.0 0.27 0.1471 0.5201 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K03 compound treatment 104360.0 16800.0 0.14 139560.0 1860.0 0.02 0.112 0.7788 1024 SPBio_001161 c1ccc2c(c1)sc3ccccc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K04 compound treatment 69760.0 -17800.0 -0.15 103240.0 -34500.0 -0.29 -0.3088 -0.9563 2566 SPBio_001162 CCCCCCCCC(=O)NCc1ccc(O)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K05 compound treatment 149440.0 61900.0 0.53 217600.0 79900.0 0.66 0.8399 0.9937 1518 SPBio_001163 OC(=O)c1cc(ccc1O)c2ccc(F)cc2F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K06 compound treatment 234040.0 146000.0 1.25 366480.0 229000.0 1.89 2.2202 0.9795 3198423 SPBio_001164 CO/N=C/1\CN(CC1CN)c2nc3n(cc(C(=O)O)c(=O)c3cc2F)C4CC4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K07 compound treatment 26480.0 -61100.0 -0.52 56960.0 -80700.0 -0.67 -0.8401 -0.9923 1240 SPBio_001165 CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K08 compound treatment 154000.0 66400.0 0.57 219880.0 82200.0 0.68 0.8807 0.9958 2060461 SPBio_001166 COc1ccc(C2COc3c(OC)c(O)ccc3C2)c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K09 compound treatment 207040.0 119000.0 1.02 268400.0 131000.0 1.08 1.4839 0.9995 1176 SPBio_001167 CC[C@@H](CO)NCCN[C@@H](CC)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K10 compound treatment 136520.0 49000.0 0.42 319680.0 182000.0 1.51 1.3593 0.8701 2560 SPBio_001168 Cc1ccc2cc3c(ccc4ccccc43)c5CCc1c52 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K11 compound treatment 216800.0 129000.0 1.1 324640.0 187000.0 1.55 1.8716 0.9861 3043753 SPBio_001169 [O-][N+](=O)c1ccc(/C=N/N2CCOC2=O)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K12 compound treatment 251840.0 164000.0 1.4 402320.0 265000.0 2.19 2.537 0.9766 2060305 SPBio_001170 CCCCC[C@H](CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K13 compound treatment 177080.0 89500.0 0.76 214040.0 76300.0 0.63 0.9855 0.9956 1000104 SPBio_001171 Cc1c(CCC(=O)O)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K14 compound treatment 47320.0 -40200.0 -0.34 147080.0 9380.0 0.08 -0.1874 -0.5334 1661997 SPBio_001172 CC12CCC3C(CCc4cc(OC(=O)c5ccccc5)ccc34)C2CCC1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K15 compound treatment 188920.0 101000.0 0.86 357520.0 220000.0 1.82 1.8961 0.942 747 SPBio_001173 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K16 compound treatment 65440.0 -22100.0 -0.19 290520.0 153000.0 1.26 0.7608 0.5952 796 SPBio_001174 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K17 compound treatment 119800.0 32200.0 0.27 331880.0 194000.0 1.61 1.33 0.8161 996 SPBio_001175 NCCc1cc(O)c(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K18 compound treatment 196560.0 109000.0 0.93 278960.0 141000.0 1.17 1.4825 0.9935 3173859 SPBio_001176 CC(C)CC(=O)OC1C(O[C@@H]2C[C@H]([C@H]3CC[C@]4(CC5CC[C@H]4[C@]3(C)C2)[C@@H](O)C5=C)C(=O)O)OC(CO)C(OS(=O)(=O)O)C1OS(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K19 compound treatment 217000.0 129000.0 1.1 342520.0 205000.0 1.69 1.9774 0.9783 958 SPBio_001177 NC(=O)NC(=O)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K20 compound treatment 12680.0 -74900.0 -0.64 22760.0 -115000.0 -0.95 -1.1232 -0.9811 1324 SPBio_001178 CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K21 compound treatment 145800.0 58200.0 0.5 262840.0 125000.0 1.04 1.0826 0.9432 881 SPBio_001179 CC12C[C@H](O)C3C(CCC4=CC(=O)CCC34C)C2CC[C@]1(O)C(=O)COP(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K22 compound treatment 66760.0 -20800.0 -0.18 196280.0 58600.0 0.48 0.2174 0.4214 1000411 SPBio_001180 CCCCCNC(=N)N/N=C/c1c[nH]c2ccc(OC)cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K23 mock treatment 109360.0 21800.0 0.19 159720.0 22000.0 0.18 0.26 1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 K24 mock treatment 43640.0 -43900.0 -0.37 202160.0 64500.0 0.53 0.1126 0.1729 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L01 mock treatment 29680.0 -57900.0 -0.49 211320.0 73600.0 0.61 0.0822 0.1049 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L02 mock treatment 82400.0 -5170.0 -0.04 201000.0 63300.0 0.52 0.3392 0.6454 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L03 compound treatment 109560.0 22000.0 0.19 183680.0 46000.0 0.38 0.4014 0.9467 3198426 SPBio_001181 NCC(CC(=O)O)c1ccc(Cl)s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L04 compound treatment 86040.0 -1530.0 -0.01 140840.0 3140.0 0.03 0.0092 0.3166 3069053 SPBio_001182 CCOC(=O)n1ccn(C)c1=S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L05 compound treatment 123040.0 35500.0 0.3 226880.0 89200.0 0.74 0.7353 0.9223 3202 SPBio_001183 COc1ccccc1N2CCN(CCCNc3cc(=O)n(C)c(=O)n3C)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L06 compound treatment 169120.0 81600.0 0.69 259400.0 122000.0 1.01 1.2029 0.9835 2069303 SPBio_001184 COC(=O)CCC(=O)O[C@H]1CCC2(C)C(CCC3C4CC5OC6(CCC(C)CO6)[C@@H](C)C5C4(C)[C@H](O)C(=O)C32)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L07 compound treatment 32400.0 -55200.0 -0.47 39360.0 -98300.0 -0.81 -0.9074 -0.9659 3177465 SPBio_001185 CO[C@@H]1C[C@H](O[C@H]2CC[C@@]3(C)[C@H](CCC4C3CC[C@]5(C)[C@H]([C@H](C[C@]45O)OC(=O)C)C6=CC(=O)OC6)C2)OC(C)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L08 compound treatment 60320.0 -27200.0 -0.23 171040.0 33300.0 0.28 0.031 0.0861 3054136 SPBio_001186 CC1(C)CC[C@]2(C)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L09 compound treatment 130800.0 43200.0 0.37 269560.0 132000.0 1.09 1.0317 0.8961 1000807 SPBio_001187 CN1CCN(CC1)C(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L10 compound treatment 106400.0 18800.0 0.16 178360.0 40700.0 0.34 0.3513 0.9426 2060309 SPBio_001188 CC12CCC3C(CCC4(O)CC(O)CCC34/C=N/NC(=O)N)C2(O)CCC1C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L11 compound treatment 49560.0 -38000.0 -0.32 114960.0 -22700.0 -0.19 -0.3618 -0.9667 3174220 SPBio_001189 CO[C@@H]1C[C@@H](C[C@H]2CC[C@H](C)[C@@H](O2)[C@@H](C)C(=O)O)O[C@]3(O[C@@](C)(C[C@H]3C)[C@H]4CC[C@](C)(O4)C5O[C@H](C[C@@H]5C)C6O[C@@](O)(CO)[C@H](C)C[C@@H]6C)[C@@H]1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L12 compound treatment 213240.0 126000.0 1.07 343240.0 206000.0 1.7 1.959 0.9751 3079388 SPBio_001190 COc1ccc2CC[C@H]3C[C@H](O)CC[C@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L13 compound treatment 12040.0 -75500.0 -0.64 26240.0 -111000.0 -0.92 -1.1067 -0.9845 2038 SPBio_001191 CCN(CC)C(=S)SSC(=S)N(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L14 compound treatment 101400.0 13800.0 0.12 312160.0 174000.0 1.44 1.1038 0.7623 967 SPBio_001192 C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C)/C=C/C=C(\C)/C=C/C2=C(C)CCCC2(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L15 compound treatment 110880.0 23300.0 0.2 316760.0 179000.0 1.48 1.1878 0.7948 1589 SPBio_001193 CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L16 compound treatment 118720.0 31200.0 0.27 280280.0 143000.0 1.18 1.0216 0.845 418 SPBio_001194 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L17 compound treatment 112920.0 25400.0 0.22 302920.0 165000.0 1.37 1.1192 0.8088 1214 SPBio_001195 CCOC(=O)Nc1c[n+](no1)N2CCOCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L18 compound treatment 153040.0 65500.0 0.56 280440.0 143000.0 1.18 1.2292 0.9413 1293 SPBio_001196 CC(=O)OCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L19 compound treatment 196800.0 109000.0 0.93 275000.0 137000.0 1.14 1.4608 0.9951 3480106 SPBio_001197 CC(C)(C(=O)O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L20 compound treatment 105520.0 18000.0 0.15 272160.0 134000.0 1.11 0.8947 0.7968 746 SPBio_001198 C(N(Cc1ccccc1)c2ccccc2)C3=NCCN3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L21 compound treatment 101480.0 13900.0 0.12 246640.0 109000.0 0.9 0.7211 0.7932 3000787 SPBio_001199 [O-][N+](=O)c1ccc(cc1)c2ccc(/C=N/N3CC(=O)NC3=O)o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L22 compound treatment 66360.0 -21200.0 -0.18 203120.0 65400.0 0.54 0.255 0.447 3177462 SPBio_001200 CCCCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(O)C[C@@]21C)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L23 mock treatment 75320.0 -12200.0 -0.1 181080.0 43400.0 0.36 0.1801 0.4818 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 L24 mock treatment 35360.0 -52200.0 -0.44 172200.0 34500.0 0.29 -0.1125 -0.2129 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M01 mock treatment 45040.0 -42500.0 -0.36 183320.0 45600.0 0.38 0.0109 0.0208 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M02 mock treatment 84560.0 -3010.0 -0.03 186760.0 49100.0 0.41 0.2689 0.6612 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M03 compound treatment 65000.0 -22600.0 -0.19 167040.0 29300.0 0.24 0.0358 0.1156 1018 SPBio_001201 COc1ccc2C[C@H]3[C@@H]4CCCC[C@@]4(CCN3C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M04 compound treatment 91320.0 3750.0 0.03 218360.0 80700.0 0.67 0.4945 0.7401 1696 SPBio_001202 CC(=O)OCC(CCn1cnc2cnc(N)nc12)COC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M05 compound treatment 117920.0 30400.0 0.26 224160.0 86500.0 0.72 0.6885 0.9053 1164 SPBio_001203 CCN(CC)C(=O)N1CCN(C)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M06 compound treatment 89840.0 2270.0 0.02 229680.0 92000.0 0.76 0.5518 0.7249 1012497 SPBio_001204 NC(Cc1c[nH]c2ccccc12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M07 compound treatment 71800.0 -15800.0 -0.13 239560.0 102000.0 0.84 0.501 0.5871 1378 SPBio_001205 NCCc1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M08 compound treatment 79920.0 -7650.0 -0.07 278240.0 141000.0 1.16 0.7761 0.6665 3055 SPBio_001206 NC(=N)NCCN1CCCCCCC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M09 compound treatment 105920.0 18400.0 0.16 275960.0 138000.0 1.14 0.9193 0.7963 1462 SPBio_001207 CC1C(CCC(C)(C)N1C)OC(=O)C(O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M10 compound treatment 122000.0 34400.0 0.29 283200.0 146000.0 1.2 1.0585 0.8544 896 SPBio_001208 COc1ccccc1OCC(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M11 compound treatment 134440.0 46900.0 0.4 272680.0 135000.0 1.12 1.0718 0.9038 1000135 SPBio_001209 CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M12 compound treatment 12080.0 -75500.0 -0.64 27560.0 -110000.0 -0.91 -1.0987 -0.9854 1238 SPBio_001210 Oc1c(Cl)cc(Cl)c(Cl)c1Cc2c(O)c(Cl)cc(Cl)c2Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M13 compound treatment 14480.0 -73100.0 -0.62 124640.0 -13100.0 -0.11 -0.5164 -0.8176 2117626 SPBio_001211 Fc1ccc(cc1)C(CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34)c5ccc(F)cc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M14 compound treatment 121120.0 33600.0 0.29 296840.0 159000.0 1.32 1.133 0.841 1344 SPBio_001212 CCCC(=O)O[C@@]1(CCC2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@@]21C)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M15 compound treatment 62880.0 -24700.0 -0.21 222440.0 84700.0 0.7 0.3471 0.4743 1115 SPBio_001213 C[C@@]12CCC3C(CCC4=C3CCC(=O)C4)C2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M16 compound treatment 17320.0 -70200.0 -0.6 170200.0 32500.0 0.27 -0.2328 -0.355 3055280 SPBio_001214 CCCCCCc1ccc(O)cc1O.Nc1c2ccccc2nc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M17 compound treatment 93560.0 5990.0 0.05 282560.0 145000.0 1.2 0.8835 0.7366 3173215 SPBio_001215 Cc1onc(c1C(=O)NC2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M18 compound treatment 102600.0 15000.0 0.13 248160.0 110000.0 0.91 0.7367 0.7984 1001518 SPBio_001216 CCC[C@H](N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCCC[C@@H]21)C(=O)O)C(=O)OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M19 compound treatment 109480.0 21900.0 0.19 264440.0 127000.0 1.05 0.8733 0.8201 952 SPBio_001217 CC(C)(S)[C@@H](N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M20 compound treatment 139640.0 52100.0 0.44 268480.0 131000.0 1.08 1.0786 0.9224 732 SPBio_001218 Oc1cc(cc([N+](=O)[O-])c1O)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M21 compound treatment 90960.0 3390.0 0.03 237160.0 99500.0 0.82 0.6023 0.7315 848 SPBio_001219 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M22 compound treatment 82000.0 -5570.0 -0.05 216720.0 79000.0 0.65 0.4288 0.6541 1402 SPBio_001220 CC[N+](C)(C)c1cccc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M23 mock treatment 60960.0 -26600.0 -0.23 165920.0 28200.0 0.23 0.0049 0.0151 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 M24 mock treatment 53160.0 -34400.0 -0.29 172360.0 34700.0 0.29 -0.0044 -0.0107 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N01 mock treatment 46400.0 -41200.0 -0.35 169960.0 32300.0 0.27 -0.0591 -0.1342 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N02 mock treatment 70880.0 -16700.0 -0.14 196560.0 58900.0 0.49 0.2439 0.4808 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N03 compound treatment 61200.0 -26400.0 -0.22 199320.0 61600.0 0.51 0.2017 0.3622 1331 SPBio_001221 CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N04 compound treatment 67400.0 -20200.0 -0.17 227160.0 89500.0 0.74 0.4019 0.529 451 SPBio_001222 Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N05 compound treatment 40200.0 -47400.0 -0.4 144800.0 7100.0 0.06 -0.2436 -0.5978 1494 SPBio_001223 C1CN(CCN1)c2ccc3ccccc3n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N06 compound treatment 25320.0 -62200.0 -0.53 35000.0 -103000.0 -0.85 -0.9755 -0.9742 1454 SPBio_001224 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CCC6C5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N07 compound treatment 14080.0 -73500.0 -0.63 40720.0 -97000.0 -0.8 -1.0097 -0.9924 1313 SPBio_001225 Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N08 compound treatment 39360.0 -48200.0 -0.41 237440.0 99700.0 0.83 0.2932 0.3182 935 SPBio_001226 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N09 compound treatment 72680.0 -14900.0 -0.13 292480.0 155000.0 1.28 0.8158 0.634 806 SPBio_001227 OC(=O)C1CCCNC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N10 compound treatment 73400.0 -14200.0 -0.12 272560.0 135000.0 1.12 0.7036 0.627 1297 SPBio_001228 COc1cc(CC=C)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N11 compound treatment 93400.0 5830.0 0.05 286960.0 149000.0 1.23 0.9083 0.735 1258 SPBio_001229 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCNCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N12 compound treatment 184080.0 96500.0 0.82 277680.0 140000.0 1.16 1.3999 0.9859 945 SPBio_001230 C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N13 compound treatment 190200.0 103000.0 0.87 253240.0 116000.0 0.96 1.2938 0.999 2555 SPBio_001231 CCOC(=O)NC1=C(C2CC2)C(=O)C(=C(C3CC3)C1=O)NC(=O)OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N14 compound treatment 123240.0 35700.0 0.3 259080.0 121000.0 1.0 0.9248 0.8815 694 SPBio_001232 C[C@H]1CC2C3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)C4(C)C=CC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N15 compound treatment 86160.0 -1410.0 -0.01 277960.0 140000.0 1.16 0.812 0.6998 448 SPBio_001233 Clc1cccc(Cl)c1N=C2NCCN2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N16 compound treatment 43920.0 -43600.0 -0.37 215320.0 77600.0 0.64 0.1913 0.2578 742 SPBio_001234 C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]3(C)C2[C@H](O)C[C@H]4/C(=C(/CCC=C(C)C)\C(=O)O)/[C@H](C[C@@]43C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N17 compound treatment 46280.0 -41300.0 -0.35 262960.0 125000.0 1.04 0.4842 0.4425 1204 SPBio_001235 CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)C(=O)N[C@]5(C)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C5=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N18 compound treatment 43680.0 -43900.0 -0.37 211680.0 74000.0 0.61 0.1686 0.2351 1261 SPBio_001236 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N19 compound treatment 78000.0 -9570.0 -0.08 241480.0 104000.0 0.86 0.5495 0.6372 3173761 SPBio_001237 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N20 compound treatment 76560.0 -11000.0 -0.09 227840.0 90100.0 0.75 0.461 0.6134 1136 SPBio_001238 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)COC(=O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N21 compound treatment 71320.0 -16200.0 -0.14 217760.0 80100.0 0.66 0.3705 0.5476 924 SPBio_001239 NC(=N)NC(=N)Nc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N22 compound treatment 52720.0 -34800.0 -0.3 154920.0 17200.0 0.14 -0.109 -0.3313 859 SPBio_001240 CC(=O)O[C@@]1(CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5C[C@@H]5[C@]4(C)C3CC[C@@]21C)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N23 mock treatment 75480.0 -12100.0 -0.1 182680.0 45000.0 0.37 0.1904 0.4931 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 N24 mock treatment 48880.0 -38700.0 -0.33 164040.0 26300.0 0.22 -0.0788 -0.1995 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O01 mock treatment 65960.0 -21600.0 -0.18 99200.0 -38500.0 -0.32 -0.3553 -0.966 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O02 mock treatment 77400.0 -10200.0 -0.09 210880.0 73200.0 0.61 0.3669 0.5999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O03 compound treatment 46560.0 -41000.0 -0.35 212440.0 74700.0 0.62 0.1903 0.2681 3172851 SPBio_001241 C[C@@H]1CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O04 compound treatment 41960.0 -45600.0 -0.39 262040.0 124000.0 1.03 0.4528 0.4118 52159 SPBio_001242 COc1ccc2[nH]cc(CCN)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O05 compound treatment 52840.0 -34700.0 -0.3 252960.0 115000.0 0.95 0.4652 0.466 3059213 SPBio_001243 COc1ccc(C(=O)c2ccccc2O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O06 compound treatment 57240.0 -30300.0 -0.26 150520.0 12800.0 0.11 -0.1076 -0.3853 1009556 SPBio_001244 Nc1c2ccccc2nc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O07 compound treatment 39360.0 -48200.0 -0.41 278960.0 141000.0 1.17 0.5361 0.4328 1112 SPBio_001245 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O08 compound treatment 4640.0 -82900.0 -0.71 21680.0 -116000.0 -0.96 -1.1779 -0.9886 2060287 SPBio_001246 Cc1c(O)c(O)cc2c1CC=C3[C@@]2(C)CC[C@@]4(C)C5C[C@@](C)(CC[C@]5(C)CC[C@]34C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O09 compound treatment 21640.0 -65900.0 -0.56 301840.0 164000.0 1.36 0.5633 0.3834 3058535 SPBio_001247 C[C@@]12CCC3C(CCc4cc(O)ccc34)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O10 compound treatment 49200.0 -38400.0 -0.33 290480.0 153000.0 1.26 0.6628 0.5077 3044526 SPBio_001248 NC(=N)N/N=C\c1c(Cl)cccc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O11 compound treatment 82040.0 -5530.0 -0.05 268800.0 131000.0 1.08 0.7336 0.6758 3177453 SPBio_001249 CC(=O)OCC(=O)[C@]12OC(C)(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]31C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O12 compound treatment 89400.0 1830.0 0.02 194640.0 56900.0 0.47 0.3441 0.7301 825 SPBio_001250 CC(Cc1ccc(O)c(O)c1)(NN)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O13 compound treatment 198480.0 111000.0 0.94 275400.0 138000.0 1.14 1.4733 0.9957 3045799 SPBio_001251 NC(=Nc1nc(CSCC/C(=N\S(=O)(=O)N)/N)cs1)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O14 compound treatment 113560.0 26000.0 0.22 322800.0 185000.0 1.53 1.2393 0.801 3173079 SPBio_001252 CC1(C)N[C@@H](C(=O)N1C2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O15 compound treatment 56680.0 -30900.0 -0.26 320680.0 183000.0 1.51 0.8844 0.5756 1509 SPBio_001253 Cn1c(COC(=O)N)ncc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O16 compound treatment 50120.0 -37400.0 -0.32 337440.0 200000.0 1.65 0.943 0.5603 2060386 SPBio_001254 CCN1C[C@]2(C)CC[C@H](OC)[C@@]34C2[C@H](O)[C@]5(OCO[C@]65C[C@H](OC)[C@H]7C[C@]4(O)C6[C@H]7O)C13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O17 compound treatment 36520.0 -51000.0 -0.43 325600.0 188000.0 1.55 0.7919 0.4906 1443 SPBio_001255 CN(C)CCOC(c1ccccc1)c2ccccc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O18 compound treatment 38920.0 -48600.0 -0.41 237360.0 99700.0 0.82 0.2901 0.3144 2857 SPBio_001256 O=C1CCc2cc(OCCCCc3nnnn3C4CCCCC4)ccc2N1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O19 compound treatment 58320.0 -29200.0 -0.25 258160.0 120000.0 1.0 0.5286 0.5146 719 SPBio_001257 CN(CC#C)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O20 compound treatment 36160.0 -51400.0 -0.44 192120.0 54400.0 0.45 0.0089 0.0141 3198424 SPBio_001258 CN(C)CCCN1C(=C(C)Sc2ccccc12)/C=C(\C=C)/C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O21 compound treatment 63400.0 -24200.0 -0.21 246880.0 109000.0 0.9 0.4932 0.5324 931 SPBio_001259 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O22 compound treatment 77560.0 -10000.0 -0.09 254200.0 117000.0 0.96 0.6213 0.6421 3059817 SPBio_001260 CCCCC(=O)N(Cc1ccc(cc1)c2ccccc2c3nn[nH]n3)[C@@H](C(C)C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O23 mock treatment 74280.0 -13300.0 -0.11 215480.0 77800.0 0.64 0.375 0.574 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 O24 mock treatment 42320.0 -45200.0 -0.39 153560.0 15900.0 0.13 -0.1796 -0.4413 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P01 mock treatment 61320.0 -26200.0 -0.22 48360.0 -89300.0 -0.74 -0.6806 -0.8815 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P02 mock treatment 76320.0 -11200.0 -0.1 123360.0 -14300.0 -0.12 -0.1516 -0.9944 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P03 compound treatment 47480.0 -40100.0 -0.34 94840.0 -42900.0 -0.35 -0.492 -0.9998 1213 SPBio_001261 CNCCc1ccccn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P04 compound treatment 32680.0 -54900.0 -0.47 121040.0 -16700.0 -0.14 -0.4279 -0.8782 3198429 SPBio_001262 CC(=O)O[C@@]1(CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P05 compound treatment 42960.0 -44600.0 -0.38 249480.0 112000.0 0.92 0.3853 0.3855 749 SPBio_001263 NC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P06 compound treatment 35880.0 -51700.0 -0.44 277760.0 140000.0 1.16 0.5082 0.41 1062 SPBio_001264 COc1ccccc1OCC(O)COC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P07 compound treatment 32880.0 -54700.0 -0.47 311240.0 174000.0 1.44 0.6859 0.4545 1119 SPBio_001265 CSCCC(NC=O)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P08 compound treatment 32880.0 -54700.0 -0.47 306200.0 169000.0 1.39 0.6565 0.4467 842 SPBio_001266 Cn1cc[nH]c1=S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P09 compound treatment 5440.0 -82100.0 -0.7 21640.0 -116000.0 -0.96 -1.1733 -0.9879 449 SPBio_001267 CC1=CC(=O)c2ccccc2C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P10 compound treatment 23200.0 -64400.0 -0.55 279680.0 142000.0 1.17 0.443 0.3418 1234 SPBio_001268 C[C@H]1CC2C3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P11 compound treatment 57400.0 -30200.0 -0.26 301640.0 164000.0 1.36 0.7774 0.5632 1464728 SPBio_001269 Cn1c(=O)[nH]c2nc[nH]c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P12 compound treatment 116600.0 29000.0 0.25 313960.0 176000.0 1.46 1.2059 0.8153 3045140 SPBio_001270 CC(C)[N+]1(C)C2CC[C@@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P13 compound treatment 123640.0 36100.0 0.31 295920.0 158000.0 1.31 1.1427 0.8499 925 SPBio_001271 C[C@@H]([C@H](O)c1ccccc1)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P14 compound treatment 70720.0 -16800.0 -0.14 317000.0 179000.0 1.48 0.9474 0.6358 1321 SPBio_001272 Cc1cc(=O)[nH]c(=S)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P15 compound treatment 50360.0 -37200.0 -0.32 260200.0 123000.0 1.01 0.4926 0.4639 1492782 SPBio_001273 OCNC(=O)c1cccnc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P16 compound treatment 30320.0 -57200.0 -0.49 233120.0 95400.0 0.79 0.2135 0.2302 884 SPBio_001274 CN(C)CCC(c1ccccc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P17 compound treatment 35880.0 -51700.0 -0.44 263560.0 126000.0 1.04 0.4251 0.376 771 SPBio_001275 CN1CCC(=C2c3ccsc3C(=O)Cc4ccccc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P18 compound treatment 24040.0 -63500.0 -0.54 322480.0 185000.0 1.53 0.6985 0.4307 822 SPBio_001276 CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P19 compound treatment 3800.0 -83800.0 -0.71 23800.0 -114000.0 -0.94 -1.1706 -0.9906 1130 SPBio_001277 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P20 compound treatment 5040.0 -82500.0 -0.7 84080.0 -53600.0 -0.44 -0.8105 -0.9754 1511 SPBio_001278 Oc1ccc(cc1)C2(OC(=O)c3ccccc32)c4ccc(O)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P21 compound treatment 56680.0 -30900.0 -0.26 180440.0 42700.0 0.35 0.0641 0.1454 752 SPBio_001279 CC1CCc2cc(F)cc3c(=O)c(cn1c23)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P22 compound treatment 90680.0 3110.0 0.03 156520.0 18800.0 0.16 0.1289 0.8158 1208 SPBio_001280 CNC[C@H](O)c1cccc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P23 mock treatment 54280.0 -33300.0 -0.28 96440.0 -41300.0 -0.34 -0.4417 -0.9957 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2161 P24 mock treatment 36680.0 -50900.0 -0.43 69720.0 -68000.0 -0.56 -0.704 -0.9917 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A01 mock treatment 112120.0 -3350.0 -0.03 58000.0 -40800.0 -0.34 -0.2591 -0.7641 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A02 mock treatment 133600.0 18100.0 0.15 124120.0 25300.0 0.21 0.257 0.9889 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A03 compound treatment 95560.0 -19900.0 -0.17 129520.0 30700.0 0.25 0.0596 0.1952 1126 SPBio_001281 O=C1NC(=O)C(N1)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A04 compound treatment 76320.0 -39100.0 -0.33 148360.0 49500.0 0.41 0.0539 0.1021 1065 SPBio_001282 CN1C(CC(O)c2ccccc2)CCCC1CC(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A05 compound treatment 63040.0 -52400.0 -0.45 191480.0 92600.0 0.77 0.2262 0.2551 968 SPBio_001283 CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A06 compound treatment 80440.0 -35000.0 -0.3 252280.0 153000.0 1.27 0.6866 0.5266 802 SPBio_001284 Oc1ccc2C(=O)c3c(O)ccc(O)c3C(=O)c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A07 compound treatment 22120.0 -93300.0 -0.79 181160.0 82300.0 0.68 -0.0805 -0.0769 976 SPBio_001285 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A08 compound treatment 56280.0 -59200.0 -0.5 209040.0 110000.0 0.91 0.2882 0.2767 1284 SPBio_001286 OC(=O)CN(CC(=O)O)Cc1cc2c(c3ccccc3C(=O)O)c4cc(CN(CC(=O)O)CC(=O)O)c(=O)cc4oc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A09 compound treatment 57040.0 -58400.0 -0.5 223320.0 124000.0 1.03 0.3764 0.3291 992 SPBio_001287 CC[C@H]1[C@@H](Cc2cncn2C)COC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A10 compound treatment 54000.0 -61500.0 -0.52 239400.0 141000.0 1.16 0.4521 0.3546 686 SPBio_001288 C(Nc1ncnc2[nH]cnc12)c3ccco3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A11 compound treatment 80800.0 -34700.0 -0.3 230400.0 132000.0 1.09 0.5608 0.4973 1428 SPBio_001289 CC(C)NCC(O)COc1cccc2[nH]ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A12 compound treatment 178880.0 63400.0 0.54 266280.0 167000.0 1.39 1.3612 0.9156 3058615 SPBio_001290 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A13 compound treatment 129480.0 14000.0 0.12 251000.0 152000.0 1.26 0.9744 0.7707 3173725 SPBio_001291 CCN1CCN(C(=O)NC(C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4)C(=O)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A14 compound treatment 83520.0 -31900.0 -0.27 270680.0 172000.0 1.42 0.8128 0.5616 2069337 SPBio_001292 COC(=O)C(C)c1ccc(cc1)C(=O)c2cccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A15 compound treatment 60240.0 -55200.0 -0.47 283960.0 185000.0 1.53 0.7503 0.4684 347 SPBio_001293 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A16 compound treatment 64920.0 -50500.0 -0.43 263120.0 164000.0 1.36 0.6566 0.4606 1606 SPBio_001294 NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A17 compound treatment 48240.0 -67200.0 -0.57 251320.0 152000.0 1.26 0.4872 0.3517 1000106 SPBio_001295 O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A18 compound treatment 56320.0 -59100.0 -0.5 251800.0 153000.0 1.27 0.5386 0.3955 2060333 SPBio_001296 COc1ccc(/C=C/c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A19 compound treatment 32720.0 -82700.0 -0.7 167320.0 68500.0 0.57 -0.0976 -0.108 349 SPBio_001297 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A20 compound treatment 21560.0 -93900.0 -0.8 101680.0 2830.0 0.02 -0.5488 -0.6861 3054675 SPBio_001298 CC(C)CCCC(C)C1CCC2/C(=C/C=C\3/C[C@@H](O)CCC3=C)/CCCC12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A21 compound treatment 83200.0 -32300.0 -0.27 156440.0 57600.0 0.48 0.1426 0.2593 1289 SPBio_001299 C[C@@]12C[C@H](O)C3C(CCC4=CC(=O)C=C[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A22 compound treatment 101600.0 -13900.0 -0.12 124400.0 25600.0 0.21 0.066 0.2725 2060331 SPBio_001300 CC1=CCC(=C)[C@H]2CC(C)(C)[C@@H]2CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A23 mock treatment 103880.0 -11600.0 -0.1 104920.0 6070.0 0.05 -0.0342 -0.3093 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 A24 mock treatment 94360.0 -21100.0 -0.18 52440.0 -46400.0 -0.38 -0.3986 -0.9402 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B01 mock treatment 149280.0 33800.0 0.29 129080.0 30200.0 0.25 0.3804 0.9975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B02 mock treatment 104360.0 -11100.0 -0.09 169200.0 70400.0 0.58 0.3447 0.5845 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B03 compound treatment 6800.0 -109000.0 -0.93 11840.0 -87000.0 -0.72 -1.1632 -0.9923 1531 SPBio_001301 O=c1n([se]c2ccccc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B04 compound treatment 80840.0 -34600.0 -0.29 208520.0 110000.0 0.91 0.4331 0.454 1339 SPBio_001302 CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B05 compound treatment 6080.0 -109000.0 -0.93 14840.0 -84000.0 -0.69 -1.15 -0.9896 1168 SPBio_001303 CC12CCC3C(CCc4cc(OCc5ccccc5)ccc34)C2C[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B06 compound treatment 81640.0 -33800.0 -0.29 253280.0 154000.0 1.28 0.6997 0.5343 691 SPBio_001304 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2C1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B07 compound treatment 17480.0 -98000.0 -0.83 28200.0 -70600.0 -0.58 -1.0032 -0.9848 2060367 SPBio_001305 CS(=O)(=O)CCCCN=C=S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B08 compound treatment 51520.0 -63900.0 -0.54 252000.0 153000.0 1.27 0.5109 0.3705 3173981 SPBio_001306 CCOC(=O)OC(C)OC(=O)C1N2C(SC1(C)C)C(NC(=O)[C@H](N)c3ccccc3)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B09 compound treatment 49680.0 -65800.0 -0.56 256160.0 157000.0 1.3 0.5242 0.3699 902 SPBio_001307 OC(=O)c1cc2cc(Cc3cccnc3)ccc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B10 compound treatment 59280.0 -56200.0 -0.48 274920.0 176000.0 1.46 0.6917 0.4512 917 SPBio_001308 NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B11 compound treatment 153800.0 38300.0 0.33 262040.0 163000.0 1.35 1.1854 0.8535 1045 SPBio_001309 C[C@@H]1CC2C3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B12 compound treatment 193880.0 78400.0 0.67 251160.0 152000.0 1.26 1.3631 0.9559 841 SPBio_001310 C/C(=C(/CCOP(=O)(O)O)\SC(=O)c1ccccc1)/N(Cc2cnc(C)nc2N)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B13 compound treatment 71240.0 -44200.0 -0.38 113080.0 14200.0 0.12 -0.183 -0.4639 1258696 SPBio_001311 Cc1c(Cl)cccc1Nc2ccccc2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B14 compound treatment 25400.0 -90100.0 -0.77 55240.0 -43600.0 -0.36 -0.7973 -0.9408 1082 SPBio_001312 CN(Cc1cc(Br)cc(Br)c1N)C2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B15 compound treatment 61760.0 -53700.0 -0.46 245560.0 147000.0 1.21 0.5349 0.4124 1196 SPBio_001313 CCCOc1ccccc1c2nc3[nH]nnc3c(=O)[nH]2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B16 compound treatment 47480.0 -68000.0 -0.58 275720.0 177000.0 1.46 0.6253 0.3974 955 SPBio_001314 CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B17 compound treatment 38200.0 -77300.0 -0.66 245120.0 146000.0 1.21 0.3905 0.2835 1076 SPBio_001315 Cc1cccc(C)c1NC2=NCCCS2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B18 compound treatment 42280.0 -73200.0 -0.62 224920.0 126000.0 1.04 0.2969 0.2443 1000338 SPBio_001316 NC[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B19 compound treatment 68960.0 -46500.0 -0.4 251280.0 152000.0 1.26 0.6117 0.4628 196 SPBio_001317 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B20 compound treatment 72080.0 -43400.0 -0.37 203160.0 104000.0 0.86 0.349 0.3718 2359 SPBio_001318 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@@H]32)n1c5ccccc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B21 compound treatment 48080.0 -67400.0 -0.57 92920.0 -5930.0 -0.05 -0.4404 -0.7647 1000121 SPBio_001319 C/C(=C\CO)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B22 compound treatment 7160.0 -108000.0 -0.92 11360.0 -87500.0 -0.72 -1.1638 -0.9928 755 SPBio_001320 CC(CN(C)C)CN1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B23 mock treatment 155120.0 39700.0 0.34 200600.0 102000.0 0.84 0.8339 0.9195 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 B24 mock treatment 144280.0 28800.0 0.25 109080.0 10200.0 0.08 0.2333 0.8991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C01 mock treatment 90200.0 -25300.0 -0.22 118840.0 20000.0 0.17 -0.0352 -0.1296 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C02 mock treatment 118840.0 3370.0 0.03 161880.0 63000.0 0.52 0.389 0.7449 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C03 compound treatment 62000.0 -53500.0 -0.46 155560.0 56700.0 0.47 0.0098 0.0151 1455 SPBio_001321 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)C=CC4(C)C3[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C04 compound treatment 102320.0 -13100.0 -0.11 186080.0 87200.0 0.72 0.4311 0.5903 1031375 SPBio_001322 NC(CCCNC(=O)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C05 compound treatment 94240.0 -21200.0 -0.18 197720.0 98900.0 0.82 0.4506 0.5379 1273 SPBio_001323 C[C@@]12CC(=O)C3C(CCC4=CC(=O)C=C[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C06 compound treatment 90480.0 -25000.0 -0.21 243680.0 145000.0 1.2 0.6968 0.5726 3054270 SPBio_001324 COC(=O)[C@@H]1C(O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C07 compound treatment 51960.0 -63500.0 -0.54 241520.0 143000.0 1.18 0.4522 0.3483 962 SPBio_001325 CCC1(C(=O)NCNC1=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C08 compound treatment 14280.0 -101000.0 -0.86 109680.0 10800.0 0.09 -0.5458 -0.6302 2060265 SPBio_001326 COC(=O)CCC(C)[C@H]1CCC2C3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C09 compound treatment 56720.0 -58700.0 -0.5 254800.0 156000.0 1.29 0.5586 0.4037 722 SPBio_001327 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C10 compound treatment 7840.0 -108000.0 -0.92 21680.0 -77200.0 -0.64 -1.0994 -0.9844 2060267 SPBio_001328 CC(CCC(=O)O)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C11 compound treatment 93920.0 -21500.0 -0.18 249760.0 151000.0 1.25 0.7531 0.5968 2431 SPBio_001329 CCN(CC)CCNC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C12 compound treatment 213520.0 98100.0 0.83 281000.0 182000.0 1.51 1.6559 0.9612 3177457 SPBio_001330 CC(CCC(=O)O)[C@H]1CCC2C3C(CC(=O)[C@]12C)[C@@]4(C)CCC(=O)C[C@H]4CC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C13 compound treatment 166680.0 51200.0 0.44 229800.0 131000.0 1.08 1.0744 0.92 779 SPBio_001331 CCN(CC)CCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C14 compound treatment 27320.0 -88100.0 -0.75 34680.0 -64200.0 -0.53 -0.9061 -0.9856 3174369 SPBio_001332 C[C@H]1OC(C[C@H](O)C1O)O[C@@H]2[C@@H](C)OC(C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6C5CC[C@]7(C)[C@H]([C@@H](O)C[C@]67O)C8=CC(=O)OC8)C4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C15 compound treatment 7120.0 -108000.0 -0.92 19360.0 -79500.0 -0.66 -1.1173 -0.9862 1041 SPBio_001333 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C16 compound treatment 59120.0 -56300.0 -0.48 239160.0 140000.0 1.16 0.4815 0.3834 2880 SPBio_001334 N[C@@H](CCC(=O)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C17 compound treatment 48880.0 -66600.0 -0.57 221800.0 123000.0 1.02 0.3183 0.2734 1057 SPBio_001335 OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C18 compound treatment 76960.0 -38500.0 -0.33 233480.0 135000.0 1.11 0.5557 0.4786 2060276 SPBio_001336 C[C@@H]1C(=O)OC2[C@H](O)C34[C@@H]5OC(=O)[C@@]4(O[C@@H]6OC(=O)[C@H](O)[C@@]63[C@@H]([C@H]5O)C(C)(C)C)[C@@]12O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C19 compound treatment 9080.0 -106000.0 -0.91 43640.0 -55200.0 -0.46 -0.9635 -0.9497 1000117 SPBio_001337 CC(=O)[C@H]1CCC2C3CCC4=CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C20 compound treatment 46320.0 -69100.0 -0.59 172960.0 74100.0 0.61 0.0172 0.0203 1275107 SPBio_001338 C1Cc2c(CN1)[nH]c3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C21 compound treatment 82000.0 -33500.0 -0.28 197120.0 98300.0 0.81 0.3734 0.4334 1397 SPBio_001339 CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C22 compound treatment 68840.0 -46600.0 -0.4 148280.0 49400.0 0.41 0.0084 0.0148 2060253 SPBio_001340 NC(CC(=O)c1ccccc1N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C23 mock treatment 72280.0 -43200.0 -0.37 179080.0 80200.0 0.66 0.2093 0.2759 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 C24 mock treatment 122680.0 7210.0 0.06 74240.0 -24600.0 -0.2 -0.1005 -0.4728 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D01 mock treatment 77720.0 -37700.0 -0.32 129200.0 30400.0 0.25 -0.0497 -0.1219 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D02 mock treatment 57280.0 -58200.0 -0.5 127720.0 28900.0 0.24 -0.1814 -0.3299 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D03 compound treatment 57480.0 -58000.0 -0.49 87960.0 -10900.0 -0.09 -0.4128 -0.8225 1205 SPBio_001341 CC(=CCC1=C(O)C(=O)c2ccccc2C1=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D04 compound treatment 90120.0 -25300.0 -0.22 202200.0 103000.0 0.86 0.452 0.5125 1385 SPBio_001342 C(/C=C/N1CCN(CC1)C(c2ccccc2)c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D05 compound treatment 31000.0 -84500.0 -0.72 36880.0 -62000.0 -0.51 -0.871 -0.9862 1277 SPBio_001343 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O[C@H]2C[C@H](O)[C@H](O[C@H]3C[C@H](OC(=O)C)[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@H](C)O3)[C@@H](C)O2)O[C@H]5CC[C@@]6(C)C(CCC7C6C[C@@H](O)[C@]8(C)[C@H](CC[C@]78O)C9=CC(=O)OC9)C5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D06 compound treatment 149440.0 34000.0 0.29 260880.0 162000.0 1.34 1.1524 0.8403 1442 SPBio_001344 CC(=O)NC1SCCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D07 compound treatment 9720.0 -106000.0 -0.9 21320.0 -77500.0 -0.64 -1.0902 -0.9862 3172730 SPBio_001345 OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NCc4ccco4)ncnc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D08 compound treatment 7440.0 -108000.0 -0.92 17760.0 -81100.0 -0.67 -1.1247 -0.988 1054 SPBio_001346 CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D09 compound treatment 93520.0 -21900.0 -0.19 270440.0 172000.0 1.42 0.8716 0.6088 1009973 SPBio_001347 OC(C(O)C(O)C(=O)O)C(O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D10 compound treatment 9840.0 -106000.0 -0.9 105880.0 7030.0 0.06 -0.5948 -0.66 716 SPBio_001348 CN(C)CCC=C1c2ccccc2C=Cc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D11 compound treatment 127040.0 11600.0 0.1 290120.0 191000.0 1.58 1.1886 0.7497 1036 SPBio_001349 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D12 compound treatment 121160.0 5690.0 0.05 197160.0 98300.0 0.81 0.6094 0.7479 1063 SPBio_001350 CC(CNCCc1ccc(O)c(O)c1)Cc2cccc(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D13 compound treatment 221760.0 106000.0 0.9 299120.0 200000.0 1.66 1.8115 0.9595 1608 SPBio_001351 NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D14 compound treatment 122320.0 6850.0 0.06 248280.0 149000.0 1.24 0.9154 0.7397 1507 SPBio_001352 CC(N)CCCC(C)(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D15 compound treatment 47560.0 -67900.0 -0.58 151080.0 52200.0 0.43 -0.1033 -0.1431 769 SPBio_001353 CCCCOc1ccc(CC(=O)NO)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D16 compound treatment 67000.0 -48500.0 -0.41 215720.0 117000.0 0.97 0.3919 0.3728 766 SPBio_001354 CC12CCC3C(CCC4=CC(=O)CCC34C)C2CCC1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D17 compound treatment 84120.0 -31300.0 -0.27 263040.0 164000.0 1.36 0.7717 0.5575 717 SPBio_001355 OC(=O)c1ccccc1OP(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D18 compound treatment 45000.0 -70500.0 -0.6 125400.0 26600.0 0.22 -0.2689 -0.4209 1348 SPBio_001356 Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D19 compound treatment 101640.0 -13800.0 -0.12 238320.0 139000.0 1.15 0.7326 0.6317 1117 SPBio_001357 Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cnc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D20 compound treatment 8280.0 -107000.0 -0.91 16000.0 -82800.0 -0.69 -1.13 -0.99 1158 SPBio_001358 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D21 compound treatment 9000.0 -106000.0 -0.91 13320.0 -85500.0 -0.71 -1.1413 -0.9925 3079211 SPBio_001359 COC(=O)[C@]1(C)CCC[C@@]2(C)C1CC(=O)c3cc(ccc32)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D22 compound treatment 101560.0 -13900.0 -0.12 170720.0 71900.0 0.59 0.3367 0.5554 3046112 SPBio_001360 CC1(C)O[C@@H]2CC3C4CCC5=CC(=O)CCC5(C)C4(F)C(O)CC3(C)[C@@]2(O1)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D23 mock treatment 82240.0 -33200.0 -0.28 174840.0 76000.0 0.63 0.2445 0.3546 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 D24 mock treatment 75320.0 -40100.0 -0.34 85400.0 -13400.0 -0.11 -0.3204 -0.8912 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E01 mock treatment 57400.0 -58100.0 -0.49 154440.0 55600.0 0.46 -0.0244 -0.0361 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E02 mock treatment 60280.0 -55200.0 -0.47 118160.0 19300.0 0.16 -0.2193 -0.4418 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E03 compound treatment 57840.0 -57600.0 -0.49 106160.0 7310.0 0.06 -0.3042 -0.6153 351 SPBio_001361 CC(C)NCC(O)COc1cccc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E04 compound treatment 112680.0 -2790.0 -0.02 229000.0 130000.0 1.08 0.7446 0.6913 2069275 SPBio_001362 CC1(C)[C@H](CC[C@@]2(C)C1CC[C@@]3(C)C4CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC(=O)C32)C(=O)O)O[C@@H]6O[C@@H]([C@@H](O[C@@H]7O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)C(=O)O)[C@H](O)[C@H]6O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E05 compound treatment 166760.0 51300.0 0.44 238520.0 140000.0 1.16 1.1258 0.9114 912 SPBio_001363 CCCc1cc(=O)[nH]c(=S)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E06 compound treatment 12520.0 -103000.0 -0.88 19720.0 -79100.0 -0.65 -1.0827 -0.9897 43 SPBio_001364 Fc1ccc(cc1)C(N2CCN(C/C=C/c3ccccc3)CC2)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E07 compound treatment 104480.0 -11000.0 -0.09 234600.0 136000.0 1.12 0.728 0.646 1000118 SPBio_001365 CN[C@@H](C)[C@@H](O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E08 compound treatment 70280.0 -45200.0 -0.38 199720.0 101000.0 0.83 0.318 0.3461 936 SPBio_001366 OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E09 compound treatment 91280.0 -24200.0 -0.21 254480.0 156000.0 1.29 0.7648 0.5865 3173593 SPBio_001367 CN1CCCN=C1/C=C/c2cccs2.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E10 compound treatment 69920.0 -45500.0 -0.39 161240.0 62400.0 0.52 0.0908 0.1406 837 SPBio_001368 CCOc1ccc2NC(C)(C)C=C(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E11 compound treatment 156720.0 41300.0 0.35 275160.0 176000.0 1.46 1.2797 0.853 889 SPBio_001369 NC(=O)c1cnccn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E12 compound treatment 147840.0 32400.0 0.28 139120.0 40300.0 0.33 0.4305 0.9956 852 SPBio_001370 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E13 compound treatment 156360.0 40900.0 0.35 202000.0 103000.0 0.85 0.8496 0.9218 830 SPBio_001371 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E14 compound treatment 115840.0 371.0 0.0 220760.0 122000.0 1.01 0.7154 0.7093 764 SPBio_001372 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)n3c(=O)[nH]c4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E15 compound treatment 23400.0 -92100.0 -0.78 61640.0 -37200.0 -0.31 -0.7719 -0.9166 3174105 SPBio_001373 CN(C)c1ccc2[n+](C)c(/C=C/c3cc(C)n(c3C)c4ccccc4)ccc2c1.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E16 compound treatment 136120.0 20700.0 0.18 255280.0 156000.0 1.29 1.0394 0.7959 805 SPBio_001374 CCc1cccc2c3CCOC(CC)(CC(=O)O)c3[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E17 compound treatment 140960.0 25500.0 0.22 290040.0 191000.0 1.58 1.2719 0.7967 792 SPBio_001375 COc1ccc2nccc([C@@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E18 compound treatment 150600.0 35100.0 0.3 251400.0 153000.0 1.26 1.1039 0.8511 1033 SPBio_001376 CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E19 compound treatment 239040.0 124000.0 1.05 246160.0 147000.0 1.22 1.6057 0.9973 836 SPBio_001377 CNC(C)C(O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E20 compound treatment 161760.0 46300.0 0.39 249000.0 150000.0 1.24 1.157 0.8878 699 SPBio_001378 OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E21 compound treatment 131280.0 15800.0 0.13 209480.0 111000.0 0.92 0.7424 0.8025 711 SPBio_001379 Oc1cccc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E22 compound treatment 82560.0 -32900.0 -0.28 181680.0 82800.0 0.69 0.2864 0.3869 1172 SPBio_001380 CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E23 mock treatment 114000.0 -1470.0 -0.01 173120.0 74300.0 0.61 0.4256 0.6926 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 E24 mock treatment 66760.0 -48700.0 -0.41 84160.0 -14700.0 -0.12 -0.3792 -0.8774 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F01 mock treatment 46520.0 -68900.0 -0.59 158800.0 60000.0 0.5 -0.0644 -0.0838 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F02 mock treatment 70600.0 -44900.0 -0.38 119200.0 20400.0 0.17 -0.1511 -0.3619 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F03 compound treatment 61280.0 -54200.0 -0.46 145600.0 46800.0 0.39 -0.0528 -0.0876 3173633 SPBio_001381 CC1=C(N2[C@H](SC1)[C@H](NC(=O)C(N)c3ccccc3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F04 compound treatment 99520.0 -15900.0 -0.14 174920.0 76100.0 0.63 0.349 0.5421 1298 SPBio_001382 CS(=O)(=O)Nc1ccc(cc1Oc2ccccc2)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F05 compound treatment 197720.0 82300.0 0.7 259720.0 161000.0 1.33 1.4363 0.955 1067 SPBio_001383 CO[C@]1(NC(=O)CSCC#N)C2SCC(=C(N2C1=O)C(=O)O)CSc3nnnn3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F06 compound treatment 195920.0 80500.0 0.68 278640.0 180000.0 1.49 1.5361 0.9381 3045662 SPBio_001384 CC(N)C(O)c1cccc(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F07 compound treatment 114880.0 -589.0 -0.01 274840.0 176000.0 1.46 1.026 0.7047 3264 SPBio_001385 Cn1nnnc1SCC2=C(N3C(SC2)C(NC(=O)C(OC=O)c4ccccc4)C3=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F08 compound treatment 166600.0 51100.0 0.44 274200.0 175000.0 1.45 1.3336 0.8805 3069629 SPBio_001386 CC(=O)/N=c/1\sc(nn1C)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F09 compound treatment 174680.0 59200.0 0.5 262600.0 164000.0 1.35 1.3144 0.9093 1323 SPBio_001387 CC1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F10 compound treatment 15160.0 -100000.0 -0.85 23840.0 -75000.0 -0.62 -1.0427 -0.9877 1286 SPBio_001388 Cc1cc(ccc1OCCOCC[N+](C)(C)Cc2ccccc2)C(C)(C)CC(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F11 compound treatment 210840.0 95400.0 0.81 298960.0 200000.0 1.66 1.7448 0.9462 1129 SPBio_001389 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F12 compound treatment 266280.0 151000.0 1.28 260680.0 162000.0 1.34 1.8546 0.9998 1535 SPBio_001390 COc1ccc(OC)c(c1)C(O)CNC(=O)CN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F13 compound treatment 275160.0 160000.0 1.36 268720.0 170000.0 1.41 1.9551 0.9999 2294 SPBio_001391 CC(=O)NC(C(=O)O)C(C)(C)SN=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F14 compound treatment 180040.0 64600.0 0.55 282800.0 184000.0 1.52 1.4648 0.9053 1055 SPBio_001392 CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F15 compound treatment 174720.0 59300.0 0.5 268880.0 170000.0 1.41 1.3514 0.9043 366 SPBio_001393 OC(=O)Cc1nn(Cc2ccc(Br)cc2F)c(=O)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F16 compound treatment 167880.0 52400.0 0.45 247480.0 149000.0 1.23 1.185 0.9059 1163 SPBio_001394 Oc1ccc2C[C@H]3N(CC4CC4)CCC5([C@H]6Oc1c25)[C@@]3(O)CCC6=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F17 compound treatment 177000.0 61500.0 0.52 262400.0 164000.0 1.35 1.3272 0.9147 1591 SPBio_001395 CC(C)C[C@@H](NC(=O)OCC1c2ccccc2-c3ccccc13)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F18 compound treatment 171880.0 56400.0 0.48 245360.0 147000.0 1.21 1.1967 0.9179 1386 SPBio_001396 CN1CC(c2ccccc2)c3cccc(N)c3C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F19 compound treatment 190200.0 74700.0 0.64 237280.0 138000.0 1.15 1.2597 0.9615 348755 SPBio_001397 OC(=O)c1cc2cc(F)ccc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F20 compound treatment 184320.0 68900.0 0.59 224280.0 125000.0 1.04 1.1483 0.9635 1436 SPBio_001398 CCCNC(C)C(=O)Nc1ccccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F21 compound treatment 174320.0 58900.0 0.5 274400.0 176000.0 1.45 1.3812 0.8991 873168 SPBio_001399 OC(=O)c1cc(O)c2ccc(Cl)cc2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F22 compound treatment 123320.0 7850.0 0.07 214080.0 115000.0 0.95 0.7213 0.7548 3480197 SPBio_001400 CCC(NC(C)C)C(O)c1ccc(O)c2[nH]c(=O)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F23 mock treatment 87120.0 -28300.0 -0.24 252080.0 153000.0 1.27 0.7257 0.5624 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 F24 mock treatment 58320.0 -57100.0 -0.49 51800.0 -47000.0 -0.39 -0.6193 -0.9939 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G01 mock treatment 74960.0 -40500.0 -0.34 100120.0 1270.0 0.01 -0.2364 -0.6852 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G02 mock treatment 63000.0 -52500.0 -0.45 110840.0 12000.0 0.1 -0.2457 -0.537 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G03 compound treatment 105480.0 -9990.0 -0.09 133760.0 34900.0 0.29 0.1441 0.4786 1264 SPBio_001401 OCc1ccccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G04 compound treatment 132960.0 17500.0 0.15 206840.0 108000.0 0.89 0.737 0.8138 1438 SPBio_001402 CC(C(=O)O)c1cccc(Oc2ccccc2)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G05 compound treatment 213560.0 98100.0 0.84 217520.0 119000.0 0.98 1.2848 0.9968 1447 SPBio_001403 NC(=O)c1ccccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G06 compound treatment 13960.0 -102000.0 -0.86 18040.0 -80800.0 -0.67 -1.0838 -0.9919 1036721 SPBio_001404 Oc1c(oc2ccccc2c1=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G07 compound treatment 153480.0 38000.0 0.32 236320.0 137000.0 1.14 1.033 0.8736 933 SPBio_001405 CN1C2C[C@@H](C[C@H]1[C@H]3OC32)OC(=O)[C@H](CO)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G08 compound treatment 107640.0 -7830.0 -0.07 203040.0 104000.0 0.86 0.5624 0.6505 3100 SPBio_001406 COc1c2OCOc2cc3CCN(C)Cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G09 compound treatment 194680.0 79200.0 0.67 265000.0 166000.0 1.37 1.4488 0.9463 3174107 SPBio_001407 CN[C@@H]1C(O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3OC(=CC[C@H]3N)CN)[C@@H]2O)OC[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G10 compound treatment 211680.0 96200.0 0.82 268360.0 170000.0 1.4 1.5708 0.9672 802058 SPBio_001408 COc1cc(/C=C/C(=O)O)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G11 compound treatment 222760.0 107000.0 0.91 279640.0 181000.0 1.5 1.7035 0.972 795 SPBio_001409 CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G12 compound treatment 245960.0 130000.0 1.11 276720.0 178000.0 1.47 1.8261 0.9904 3173760 SPBio_001410 COc1cc2CCN(C)[C@@H]3Cc4cccc(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)c(O)c5)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G13 compound treatment 253240.0 138000.0 1.17 268800.0 170000.0 1.41 1.8236 0.9959 3059108 SPBio_001411 CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)C13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G14 compound treatment 187440.0 72000.0 0.61 205880.0 107000.0 0.89 1.0594 0.9838 1144 SPBio_001412 O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G15 compound treatment 208880.0 93400.0 0.8 222160.0 123000.0 1.02 1.2837 0.9924 1155 SPBio_001413 Nc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G16 compound treatment 87120.0 -28300.0 -0.24 100480.0 1630.0 0.01 -0.1611 -0.6665 2081691 SPBio_001414 CC(=CCC/C(=C/CC/C(=C/CO)/C)/C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G17 compound treatment 190360.0 74900.0 0.64 226080.0 127000.0 1.05 1.1952 0.9712 878 SPBio_001415 CC(=O)NS(=O)(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G18 compound treatment 199720.0 84300.0 0.72 266120.0 167000.0 1.38 1.4857 0.9532 1203 SPBio_001416 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G19 compound treatment 227200.0 112000.0 0.95 255680.0 157000.0 1.3 1.5901 0.9884 1159 SPBio_001417 Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G20 compound treatment 170400.0 54900.0 0.47 205680.0 107000.0 0.88 0.9557 0.9557 1346 SPBio_001418 CCN(CC)CCNC(=O)COc1ccc(OC)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G21 compound treatment 187240.0 71800.0 0.61 218640.0 120000.0 0.99 1.1329 0.973 1177 SPBio_001419 Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G22 compound treatment 162840.0 47400.0 0.4 215880.0 117000.0 0.97 0.9698 0.9247 1210 SPBio_001420 CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G23 mock treatment 117240.0 1770.0 0.02 167800.0 69000.0 0.57 0.414 0.7255 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 G24 mock treatment 62160.0 -53300.0 -0.45 41320.0 -57500.0 -0.48 -0.6575 -0.9997 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H01 mock treatment 98440.0 -17000.0 -0.14 68280.0 -30600.0 -0.25 -0.2813 -0.9651 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H02 mock treatment 79640.0 -35800.0 -0.31 107960.0 9110.0 0.08 -0.1624 -0.5168 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H03 compound treatment 93640.0 -21800.0 -0.19 146960.0 48100.0 0.4 0.15 0.3415 1364 SPBio_001421 OC(=O)/C(=C/c1cccc(O)c1)/C#N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H04 compound treatment 116840.0 1370.0 0.01 156280.0 57400.0 0.48 0.3442 0.7243 3173855 SPBio_001422 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H05 compound treatment 15120.0 -100000.0 -0.85 16200.0 -82600.0 -0.68 -1.0876 -0.9939 829 SPBio_001423 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H06 compound treatment 220320.0 105000.0 0.89 246600.0 148000.0 1.22 1.4956 0.9881 1270 SPBio_001424 C[N+](C)(C)CCCCCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H07 compound treatment 187840.0 72400.0 0.62 232840.0 134000.0 1.11 1.2195 0.9616 3061087 SPBio_001425 NC/C=C/C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H08 compound treatment 169800.0 54300.0 0.46 241840.0 143000.0 1.18 1.1636 0.9161 1242 SPBio_001426 CN(CS(=O)(=O)O)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H09 compound treatment 230960.0 115000.0 0.98 245280.0 146000.0 1.21 1.5519 0.9946 3684 SPBio_001427 OC(=O)C1=CCCNC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H10 compound treatment 19560.0 -95900.0 -0.82 22360.0 -76500.0 -0.63 -1.0248 -0.9921 1342 SPBio_001428 CN(C)C(=S)SSC(=S)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H11 compound treatment 259120.0 144000.0 1.22 262280.0 163000.0 1.35 1.8209 0.9987 1923 SPBio_001429 NC1(CC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H12 compound treatment 283720.0 168000.0 1.43 278400.0 180000.0 1.49 2.0633 0.9998 3173628 SPBio_001430 CN1C(C)(C)CCCC1(C)C.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H13 compound treatment 289320.0 174000.0 1.48 285360.0 187000.0 1.54 2.1377 0.9998 1111718 SPBio_001431 NC1(CCC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H14 compound treatment 162640.0 47200.0 0.4 164080.0 65200.0 0.54 0.6656 0.9894 758 SPBio_001432 CCCOc1ccc2nc(NC(=O)OC)[nH]c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H15 compound treatment 93280.0 -22200.0 -0.19 109920.0 11100.0 0.09 -0.0688 -0.3277 121 SPBio_001433 OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H16 compound treatment 185560.0 70100.0 0.6 185360.0 86500.0 0.72 0.9281 0.9959 1410 SPBio_001434 S=P(N1CC1)(N2CC2)N3CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H17 compound treatment 214560.0 99100.0 0.84 251920.0 153000.0 1.27 1.492 0.9805 1594 SPBio_001435 N[C@@H](CCCNC(=N)N[N+](=O)[O-])C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H18 compound treatment 230160.0 115000.0 0.98 238200.0 139000.0 1.15 1.5057 0.9966 1080 SPBio_001436 N[C@H](Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H19 compound treatment 236360.0 121000.0 1.03 245240.0 146000.0 1.21 1.5842 0.9967 1458 SPBio_001437 NC(Cc1ccc(Cl)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H20 compound treatment 235560.0 120000.0 1.02 215760.0 117000.0 0.97 1.4069 0.9996 1528 SPBio_001438 NC(=O)c1ncn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H21 compound treatment 163280.0 47800.0 0.41 221760.0 123000.0 1.02 1.0069 0.9193 3198954 SPBio_001439 CC[C@H](C)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H22 compound treatment 14040.0 -101000.0 -0.86 43520.0 -55300.0 -0.46 -0.9343 -0.9559 846 SPBio_001440 Cc1nc2sccn2c(=O)c1CCN3CCC(=C(c4ccc(F)cc4)c5ccc(F)cc5)CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H23 mock treatment 95400.0 -20100.0 -0.17 157040.0 58200.0 0.48 0.2196 0.4299 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 H24 mock treatment 71000.0 -44500.0 -0.38 42400.0 -56400.0 -0.47 -0.5979 -0.9946 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I01 mock treatment 101520.0 -13900.0 -0.12 55400.0 -43400.0 -0.36 -0.3381 -0.8933 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I02 mock treatment 106080.0 -9390.0 -0.08 115920.0 17100.0 0.14 0.0433 0.2671 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I03 compound treatment 116360.0 891.0 0.01 159040.0 60200.0 0.5 0.3575 0.7178 934 SPBio_001441 Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I04 compound treatment 117800.0 2330.0 0.02 107280.0 8430.0 0.07 0.0634 0.8736 1350 SPBio_001442 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I05 compound treatment 240280.0 125000.0 1.06 250120.0 151000.0 1.25 1.6363 0.9967 799 SPBio_001443 Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I06 compound treatment 38080.0 -77400.0 -0.66 37640.0 -61200.0 -0.51 -0.824 -0.9915 1233 SPBio_001444 CO[C@@H]1[C@@H](O)[C@H](C)O[C@H](O[C@H]2CC[C@@]3(C=O)[C@H](CCC4C3CC[C@]5(C)[C@H](CC[C@]45O)C6=CC(=O)OC6)C2)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I07 compound treatment 213040.0 97600.0 0.83 231320.0 132000.0 1.1 1.3624 0.9907 867 SPBio_001445 Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I08 compound treatment 241200.0 126000.0 1.07 245600.0 147000.0 1.21 1.6154 0.998 3173860 SPBio_001446 O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5OC1[C@]2(CCN3CC6CCC6)c54 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I09 compound treatment 215160.0 99700.0 0.85 216480.0 118000.0 0.97 1.2883 0.9977 753 SPBio_001447 O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I10 compound treatment 214720.0 99300.0 0.85 215240.0 116000.0 0.96 1.2784 0.9979 714 SPBio_001448 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc2ccc(OC)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I11 compound treatment 258640.0 143000.0 1.22 261680.0 163000.0 1.35 1.8145 0.9988 1192 SPBio_001449 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I12 compound treatment 92680.0 -22800.0 -0.19 101200.0 2350.0 0.02 -0.1234 -0.633 3174345 SPBio_001450 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N.OC(=O)c1cc(ccc1O)S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I13 compound treatment 286000.0 171000.0 1.45 243040.0 144000.0 1.19 1.8702 0.9952 1212 SPBio_001451 CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C/c3ccc(cc3)S(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I14 compound treatment 266480.0 151000.0 1.29 234200.0 135000.0 1.12 1.7009 0.9976 1291 SPBio_001452 CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I15 compound treatment 256800.0 141000.0 1.2 224360.0 126000.0 1.04 1.5851 0.9973 743 SPBio_001453 CC(C)(C)NCC(O)c1cc(O)cc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I16 compound treatment 244240.0 129000.0 1.1 209000.0 110000.0 0.91 1.4196 0.9958 728 SPBio_001454 Cc1cc(nnc1NCCN2CCOCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I17 compound treatment 60080.0 -55400.0 -0.47 57440.0 -41400.0 -0.34 -0.5757 -0.9877 1218 SPBio_001455 CCCCNc1ccc(cc1)C(=O)OCCN(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I18 compound treatment 214480.0 99000.0 0.84 189880.0 91000.0 0.75 1.1286 0.9984 733 SPBio_001456 CC1(CC2CC3(C)C1)CC(N)(C2)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I19 compound treatment 268960.0 153000.0 1.31 249680.0 151000.0 1.25 1.8064 0.9997 1418 SPBio_001457 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I20 compound treatment 219040.0 104000.0 0.88 214480.0 116000.0 0.96 1.3 0.9992 983 SPBio_001458 NCCCS(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I21 compound treatment 196080.0 80600.0 0.69 178440.0 79600.0 0.66 0.9509 0.9998 1444 SPBio_001459 C1CN=C(N1)C2CCCc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I22 compound treatment 154840.0 39400.0 0.34 175160.0 76300.0 0.63 0.6834 0.9561 840551 SPBio_001460 NCCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I23 mock treatment 141560.0 26100.0 0.22 161600.0 62800.0 0.52 0.5242 0.9283 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 I24 mock treatment 85240.0 -30200.0 -0.26 41400.0 -57400.0 -0.48 -0.518 -0.9585 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J01 mock treatment 167160.0 51700.0 0.44 48680.0 -50200.0 -0.42 0.0177 0.0293 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J02 mock treatment 148120.0 32700.0 0.28 103680.0 4830.0 0.04 0.2248 0.8006 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J03 compound treatment 186040.0 70600.0 0.6 158240.0 59400.0 0.49 0.7723 0.995 3471022 SPBio_001461 CC(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J04 compound treatment 184120.0 68700.0 0.58 163120.0 64300.0 0.53 0.7893 0.9989 3173083 SPBio_001462 CO[C@H]1[C@H](O)CC(=O)O[C@@H](C)C/C=C/C=C/[C@H](O[C@H]2CC[C@@H]([C@@H](C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1O[C@@H]3O[C@H](C)[C@@H](O[C@H]4C[C@@](C)(O)[C@H](O)[C@H](C)O4)[C@@H]([C@H]3O)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J05 compound treatment 164520.0 49100.0 0.42 138480.0 39600.0 0.33 0.5272 0.9928 1581 SPBio_001463 CNC(=N)NCCCC(N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J06 compound treatment 175400.0 59900.0 0.51 142640.0 43800.0 0.36 0.617 0.9859 115 SPBio_001464 COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J07 compound treatment 215720.0 100000.0 0.85 183200.0 84400.0 0.7 1.097 0.995 869 SPBio_001465 CCC1(C)CC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J08 compound treatment 265320.0 150000.0 1.28 212600.0 114000.0 0.94 1.5676 0.9888 839 SPBio_001466 Nc1nc2n(COCCO)cnc2c(=O)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J09 compound treatment 189520.0 74100.0 0.63 144360.0 45500.0 0.38 0.7121 0.9696 3172968 SPBio_001467 CCC1NC(=O)C(C(O)C(C)C/C=C/C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J10 compound treatment 263920.0 148000.0 1.26 227120.0 128000.0 1.06 1.6441 0.9962 897 SPBio_001468 CCCCCCCCCCCCCCCC(=O)OC/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J11 compound treatment 263400.0 148000.0 1.26 220640.0 122000.0 1.01 1.6031 0.9939 3173475 SPBio_001469 CO[C@H]1C[C@H](O[C@H]2[C@H](C)[C@@H](OC3O[C@H](C)C[C@@H]([C@H]3OC(=O)C)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](OC(=O)C)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)O[C@@H](C)[C@@H]1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J12 compound treatment 239960.0 124000.0 1.06 211200.0 112000.0 0.93 1.4067 0.9979 117 SPBio_001470 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J13 compound treatment 281760.0 166000.0 1.42 240320.0 141000.0 1.17 1.8287 0.9955 3198430 SPBio_001471 CC(C)C(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(NC(=O)C(F)(F)F)C(C)C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J14 compound treatment 23840.0 -91600.0 -0.78 18720.0 -80100.0 -0.66 -1.0204 -0.9967 1417 SPBio_001472 CCCCCCCCCCCCC[N+](C)(C)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J15 compound treatment 265600.0 150000.0 1.28 204120.0 105000.0 0.87 1.5197 0.9825 3079212 SPBio_001473 NCCCN.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J16 compound treatment 260000.0 145000.0 1.23 198800.0 100000.0 0.83 1.4548 0.9813 757 SPBio_001474 OC(=O)c1cn(C2CC2)c3cc(N4CCNCC4)c(F)cc3c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J17 compound treatment 240080.0 125000.0 1.06 185520.0 86700.0 0.72 1.2572 0.9818 3198431 SPBio_001475 CC(C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J18 compound treatment 268680.0 153000.0 1.3 204960.0 106000.0 0.88 1.5431 0.9814 1038 SPBio_001476 O=C1CCCN1CC#CCN2CCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J19 compound treatment 202840.0 87400.0 0.74 194040.0 95200.0 0.79 1.0829 0.9996 1095029 SPBio_001477 CCCCCCCCCCCCCCCCCCOP(=O)(O)OCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J20 compound treatment 68480.0 -47000.0 -0.4 27720.0 -71100.0 -0.59 -0.699 -0.9823 382 SPBio_001478 NCCCCCCNS(=O)(=O)c1cccc2c(Cl)cccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J21 compound treatment 216800.0 101000.0 0.86 179920.0 81100.0 0.67 1.0843 0.9922 3079213 SPBio_001479 N[C@@H](CCC(=O)N[C@@H](CCSC(CC(=O)O)C(=O)O)C(=O)NCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J22 compound treatment 173280.0 57800.0 0.49 168400.0 69600.0 0.58 0.7549 0.997 1512 SPBio_001480 CC(C)NCC(O)c1ccc2ccccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J23 mock treatment 153960.0 38500.0 0.33 131800.0 33000.0 0.27 0.4245 0.9958 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 J24 mock treatment 116520.0 1050.0 0.01 50200.0 -48600.0 -0.4 -0.2782 -0.6912 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K01 mock treatment 185480.0 70000.0 0.6 32920.0 -65900.0 -0.55 0.0359 0.0444 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K02 mock treatment 137480.0 22000.0 0.19 100680.0 1830.0 0.02 0.1432 0.7618 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K03 compound treatment 114240.0 -1230.0 -0.01 108440.0 9590.0 0.08 0.0487 0.6086 737 SPBio_001481 c1nc(cs1)c2nc3ccccc3[nH]2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K04 compound treatment 193960.0 78500.0 0.67 171640.0 72800.0 0.6 0.8984 0.9986 723 SPBio_001482 CC(C)NCC(O)COc1ccc(CC(=O)N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K05 compound treatment 13840.0 -102000.0 -0.87 10320.0 -88500.0 -0.73 -1.1297 -0.9966 731 SPBio_001483 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K06 compound treatment 125440.0 9970.0 0.08 109880.0 11000.0 0.09 0.1246 0.9993 990 SPBio_001484 CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K07 compound treatment 54800.0 -60700.0 -0.52 39040.0 -59800.0 -0.49 -0.7151 -0.9998 972 SPBio_001485 CN(C)S(=O)(=O)c1ccc2Sc3ccccc3/C(=C\CCN4CCN(C)CC4)/c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K08 compound treatment 199000.0 83500.0 0.71 151240.0 52400.0 0.43 0.8094 0.9718 338 SPBio_001486 Nc1ccncc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K09 compound treatment 269280.0 154000.0 1.31 189720.0 90900.0 0.75 1.4576 0.9653 833 SPBio_001487 CC(C)(C)NC[C@@H](O)COc1nsnc1N2CCOCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K10 compound treatment 163680.0 48200.0 0.41 156560.0 57700.0 0.48 0.6279 0.9972 783 SPBio_001488 CO[C@@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]2Cc4cn(C)c5cccc1c45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K11 compound treatment 300600.0 185000.0 1.58 209440.0 111000.0 0.91 1.7615 0.9665 2572 SPBio_001489 COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7ccc(Oc(c1O)c32)cc7)N(C)CCc6cc5OC)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K12 compound treatment 97560.0 -17900.0 -0.15 83880.0 -15000.0 -0.12 -0.1954 -0.9947 86 SPBio_001490 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCN(C)Cc3ccccc3)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K13 compound treatment 209400.0 93900.0 0.8 189400.0 90600.0 0.75 1.0952 0.9995 1000109 SPBio_001491 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@@H]3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K14 compound treatment 248640.0 133000.0 1.13 160160.0 61300.0 0.51 1.1604 0.9342 1016 SPBio_001492 CN1CCOC(c2ccccc2)c3ccccc3C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K15 compound treatment 331200.0 216000.0 1.84 158640.0 59800.0 0.49 1.6486 0.8667 883 SPBio_001493 CC(Oc1ccccc1)C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K16 compound treatment 279440.0 164000.0 1.4 136200.0 37400.0 0.31 1.2057 0.8432 786 SPBio_001494 CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K17 compound treatment 205240.0 89800.0 0.76 94680.0 -4170.0 -0.03 0.5161 0.6745 824 SPBio_001495 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@@](O)(C(=O)OC)n4c5ccccc35 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K18 compound treatment 245120.0 130000.0 1.1 179600.0 80800.0 0.67 1.2529 0.9711 741 SPBio_001496 Cc1ccccc1OCC(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K19 compound treatment 213840.0 98400.0 0.84 198120.0 99300.0 0.82 1.173 1.0 1052 SPBio_001497 CC[C@H]1CN2CCC1C[C@@H]2[C@@H](O)c3ccnc4ccc(OC)cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K20 compound treatment 238480.0 123000.0 1.05 170880.0 72000.0 0.6 1.162 0.9643 751 SPBio_001498 COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K21 compound treatment 194480.0 79000.0 0.67 137440.0 38600.0 0.32 0.7014 0.942 1223 SPBio_001499 CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K22 compound treatment 138080.0 22600.0 0.19 104920.0 6070.0 0.05 0.1717 0.8627 1241 SPBio_001500 NC(=N)NS(=O)(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K23 mock treatment 122120.0 6650.0 0.06 125600.0 26800.0 0.22 0.1965 0.8603 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 K24 mock treatment 173000.0 57500.0 0.49 38160.0 -60700.0 -0.5 -0.0086 -0.0123 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L01 mock treatment 200680.0 85200.0 0.73 32280.0 -66600.0 -0.55 0.1236 0.1357 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L02 mock treatment 169360.0 53900.0 0.46 75160.0 -23700.0 -0.2 0.1859 0.3726 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L03 compound treatment 139200.0 23700.0 0.2 109440.0 10600.0 0.09 0.2048 0.9301 3198432 SPBio_001501 CSC(=N)NCCC[C@@H](N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L04 compound treatment 53240.0 -62200.0 -0.53 36040.0 -62800.0 -0.52 -0.742 -1.0 1269 SPBio_001502 CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L05 compound treatment 120480.0 5010.0 0.04 80800.0 -18000.0 -0.15 -0.0754 -0.4856 3198433 SPBio_001503 NC(Cc1c[nH]cn1)C(=O)Nc2ccc3ccccc3c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L06 compound treatment 240400.0 125000.0 1.06 182560.0 83700.0 0.69 1.2418 0.9784 1486 SPBio_001504 CC(C)NCC(O)COc1ccc(NC(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L07 compound treatment 16640.0 -98800.0 -0.84 10200.0 -88600.0 -0.73 -1.1136 -0.9977 3176939 SPBio_001505 ClCC(=O)[C@H](Cc1ccccc1)NC(=O)OCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L08 compound treatment 172880.0 57400.0 0.49 74600.0 -24200.0 -0.2 0.2038 0.3857 1415 SPBio_001506 FC(F)(F)c1cccc(c1)N2CCNCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L09 compound treatment 256960.0 141000.0 1.2 205080.0 106000.0 0.88 1.4733 0.988 3198434 SPBio_001507 NCCCC[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L10 compound treatment 209160.0 93700.0 0.8 153600.0 54800.0 0.45 0.8844 0.964 419 SPBio_001508 CC1=NN(C(=O)C1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L11 compound treatment 276840.0 161000.0 1.37 217040.0 118000.0 0.98 1.6629 0.9861 3079214 SPBio_001509 CC(C)CC(NC(=O)CN)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L12 compound treatment 288520.0 173000.0 1.47 186040.0 87200.0 0.72 1.5519 0.946 907188 SPBio_001510 COc1cccc(OC)c1OCCNCC2COc3ccccc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L13 compound treatment 306040.0 191000.0 1.62 256160.0 157000.0 1.3 2.0676 0.994 3198435 SPBio_001511 N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L14 compound treatment 64800.0 -50700.0 -0.43 31800.0 -67000.0 -0.55 -0.6973 -0.9923 1478 SPBio_001512 Cc1ccc(cc1)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L15 compound treatment 45560.0 -69900.0 -0.6 24040.0 -74800.0 -0.62 -0.8585 -0.9998 2269 SPBio_001513 Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L16 compound treatment 304640.0 189000.0 1.61 140720.0 41900.0 0.35 1.3839 0.84 445 SPBio_001514 NC(=O)c1cccc(N)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L17 compound treatment 244160.0 129000.0 1.1 100960.0 2110.0 0.02 0.7871 0.7183 3054972 SPBio_001515 CC(C)C1=CC2=CCC3[C@](C)(CCC[C@]3(C)C2CC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L18 compound treatment 225480.0 110000.0 0.94 93440.0 -5410.0 -0.04 0.6307 0.6726 1248 SPBio_001516 C[C@@]12CCC3C(CCc4cc(OC(=O)CCC(=O)O)ccc34)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L19 compound treatment 236640.0 121000.0 1.03 189600.0 90800.0 0.75 1.2604 0.9878 3079215 SPBio_001517 CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L20 compound treatment 231240.0 116000.0 0.99 134760.0 35900.0 0.3 0.9071 0.8811 2060318 SPBio_001518 C/C(=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@]12O[C@]2(C)C[C@@H](O)CC1(C)C)/C=C/C=C(\C)/C=C/C3=C(C)C[C@@H](O)CC3(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L21 compound treatment 206760.0 91300.0 0.78 151240.0 52400.0 0.43 0.8561 0.962 740 SPBio_001519 N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L22 compound treatment 153760.0 38300.0 0.33 113800.0 15000.0 0.12 0.318 0.912 1023 SPBio_001520 CN[C@H](CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L23 mock treatment 157960.0 42500.0 0.36 114280.0 15400.0 0.13 0.3461 0.9021 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 L24 mock treatment 137400.0 21900.0 0.19 49520.0 -49300.0 -0.41 -0.1565 -0.3488 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M01 mock treatment 195000.0 79500.0 0.68 40560.0 -58300.0 -0.48 0.1379 0.1658 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M02 mock treatment 167520.0 52100.0 0.44 86920.0 -11900.0 -0.1 0.2436 0.5365 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M03 compound treatment 118320.0 2850.0 0.02 67880.0 -31000.0 -0.26 -0.164 -0.6372 2069343 SPBio_001521 COc1ccc2[C@H](OC(=O)c2c1OC)[C@H]3N(C)CCc4cc5OCOc5cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M04 compound treatment 180920.0 65500.0 0.56 99120.0 273.0 0.0 0.3956 0.71 1529 SPBio_001522 COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M05 compound treatment 196360.0 80900.0 0.69 107120.0 8270.0 0.07 0.5354 0.7736 949 SPBio_001523 OC(=O)c1cc(O)c2ccccc2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M06 compound treatment 17720.0 -97700.0 -0.83 8840.0 -90000.0 -0.74 -1.115 -0.9985 871 SPBio_001524 Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M07 compound treatment 247560.0 132000.0 1.12 96000.0 -2850.0 -0.02 0.7786 0.6921 362 SPBio_001525 CCN(CC)CC(=O)Nc1c(C)cccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M08 compound treatment 204440.0 89000.0 0.76 105480.0 6630.0 0.05 0.5745 0.7563 3480067 SPBio_001526 CC(NCCc1ccc(O)cc1)C(O)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M09 compound treatment 282320.0 167000.0 1.42 155240.0 56400.0 0.47 1.3344 0.8924 988 SPBio_001527 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M10 compound treatment 248840.0 133000.0 1.14 153720.0 54900.0 0.45 1.124 0.9191 3058009 SPBio_001528 CCN1CCC(CNC(=O)c2cc(ccc2OC)S(=O)(=O)N)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M11 compound treatment 279000.0 164000.0 1.39 168320.0 69500.0 0.57 1.3909 0.9234 898 SPBio_001529 CCOC(=O)C(Cc1ccc(O)cc1)NC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M12 compound treatment 258240.0 143000.0 1.22 199920.0 101000.0 0.84 1.4508 0.9833 1068 SPBio_001530 CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(CN(C)C)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M13 compound treatment 249080.0 134000.0 1.14 215000.0 116000.0 0.96 1.4839 0.9965 993 SPBio_001531 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M14 compound treatment 228480.0 113000.0 0.96 91600.0 -7250.0 -0.06 0.638 0.6618 1180 SPBio_001532 Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M15 compound treatment 271920.0 156000.0 1.33 104920.0 6070.0 0.05 0.9774 0.7333 1073 SPBio_001533 CC(N)C(=O)NC(Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M16 compound treatment 20000.0 -95500.0 -0.81 11040.0 -87800.0 -0.73 -1.0884 -0.9984 998 SPBio_001534 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M17 compound treatment 256240.0 141000.0 1.2 93560.0 -5290.0 -0.04 0.8166 0.6809 1017 SPBio_001535 CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M18 compound treatment 243200.0 128000.0 1.09 106200.0 7350.0 0.06 0.812 0.7455 1094 SPBio_001536 COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M19 compound treatment 227760.0 112000.0 0.96 143640.0 44800.0 0.37 0.9381 0.9149 1034 SPBio_001537 CC(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M20 compound treatment 230760.0 115000.0 0.98 116080.0 17200.0 0.14 0.7949 0.8014 887 SPBio_001538 COc1ccc(NS(=O)(=O)c2ccc(N)cc2)nn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M21 compound treatment 221560.0 106000.0 0.9 129880.0 31000.0 0.26 0.8203 0.8735 1523 SPBio_001539 CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M22 compound treatment 172880.0 57400.0 0.49 84720.0 -14100.0 -0.12 0.263 0.5233 1102 SPBio_001540 CC(C(=O)O)c1ccc(cc1)C(=O)c2cccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M23 mock treatment 151320.0 35900.0 0.31 82160.0 -16700.0 -0.14 0.1182 0.3529 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 M24 mock treatment 153040.0 37600.0 0.32 52240.0 -46600.0 -0.39 -0.0464 -0.0927 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N01 mock treatment 160120.0 44700.0 0.38 67360.0 -31500.0 -0.26 0.0846 0.1836 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N02 mock treatment 193920.0 78500.0 0.67 96600.0 -2250.0 -0.02 0.4592 0.6872 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N03 compound treatment 203240.0 87800.0 0.75 67760.0 -31100.0 -0.26 0.3466 0.4385 3054980 SPBio_001541 Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](CO)O3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N04 compound treatment 211720.0 96300.0 0.82 79480.0 -19400.0 -0.16 0.4662 0.5583 3174610 SPBio_001542 COc1cc(cc(OC)c1OC)C(=O)O[C@H]2CC[C@@]3(C)[C@@H]4CC[C@@H]5[C@@]3(C[C@@]6(O)[C@@H]7CN8C[C@@H](C)CC[C@H]8[C@@](C)(O)[C@@]7(O)[C@@H](O)C[C@@]56O)O[C@@]42O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N05 compound treatment 255320.0 140000.0 1.19 81400.0 -17400.0 -0.14 0.7399 0.6169 2060304 SPBio_001543 OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N06 compound treatment 279200.0 164000.0 1.39 70160.0 -28700.0 -0.24 0.8179 0.5784 882 SPBio_001544 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N07 compound treatment 266360.0 151000.0 1.28 87720.0 -11100.0 -0.09 0.8434 0.6548 2060308 SPBio_001545 C/C(=C/C(=O)O)/C=C/C1(O)C(=CC(=O)CC1(C)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N08 compound treatment 18760.0 -96700.0 -0.82 7800.0 -91000.0 -0.75 -1.1148 -0.999 3198436 SPBio_001546 CO[C@H]1CC(O[C@H]/2[C@@H](C)\C=C\C=C\3/CO[C@@H]4\C(=N/O)\C(=C[C@@H](C(=O)O[C@H]5C[C@@H](C\C=C2/C)O[C@@]6(CC[C@H](C)[C@H](O6)C7CCCCC7)C5)[C@@]43O)C)O[C@@H](C)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N09 compound treatment 184360.0 68900.0 0.59 75480.0 -23400.0 -0.19 0.2781 0.4503 1039 SPBio_001547 CC[C@]1(CCCN2CCc3c4[C@@H]21)CC(=O)n4c5ccccc35 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N10 compound treatment 91640.0 -23800.0 -0.2 39080.0 -59800.0 -0.49 -0.4931 -0.9226 1389 SPBio_001548 CCOC(=O)N1CCC(=C2c3ccc(Cl)cc3CCc4cccnc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N11 compound treatment 242160.0 127000.0 1.08 128120.0 29300.0 0.24 0.934 0.8448 1583 SPBio_001549 COc1ccc(/C=C/c2cc(O)cc(O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c2)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N12 compound treatment 73040.0 -42400.0 -0.36 39640.0 -59200.0 -0.49 -0.6018 -0.9888 3174609 SPBio_001550 CC(C)c1c(C(=O)c2ccccc2)c(c(c3ccc(F)cc3)n1CC[C@@H](O)C[C@@H](O)CC(=O)O)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N13 compound treatment 175840.0 60400.0 0.51 129240.0 30400.0 0.25 0.5413 0.9459 1010348 SPBio_001551 OC1=CC(=O)c2ccccc2C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N14 compound treatment 256520.0 141000.0 1.2 145680.0 46800.0 0.39 1.1232 0.8901 3172973 SPBio_001552 COC(=O)[C@@]1(O)OC[C@]2(C3[C@H]4OC[C@@]3([C@@H](C[C@@H]2OC(=O)/C(=C/C)/C)OC(=O)C)C(=O)OC)[C@@H]1[C@@](C)([C@@H]4O)C56O[C@@]6(C)[C@H]7C[C@@H]5OC8OC=C[C@]78O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N15 compound treatment 218560.0 103000.0 0.88 40160.0 -58700.0 -0.49 0.2774 0.2765 3054057 SPBio_001553 CC(=CCC/C(=C/CCC(C)(O)C=C)/C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N16 compound treatment 16840.0 -98600.0 -0.84 6000.0 -92800.0 -0.77 -1.1369 -0.999 1520 SPBio_001554 CC[n+]1c(c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N17 compound treatment 259560.0 144000.0 1.23 63840.0 -35000.0 -0.29 0.6627 0.5257 1002002 SPBio_001555 O[C@@H]1CC(=C[C@@H](O)[C@H]1O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N18 compound treatment 270720.0 155000.0 1.32 65920.0 -32900.0 -0.27 0.7421 0.5498 1457 SPBio_001556 CC(=O)OCC(=O)[C@]12OC3(CCCC3)O[C@@H]2CC4C5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@@]41C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N19 compound treatment 172120.0 56700.0 0.48 89800.0 -9050.0 -0.07 0.2881 0.5903 797 SPBio_001557 CC[C@]1(CC[C@@H](O1)[C@]2(C)CCC3(C[C@H](O)[C@@H](C)[C@H](O3)[C@H](C)[C@@H](OC)[C@H](C)C(=O)O)O2)C4O[C@H](C[C@@H]4C)C5O[C@@](O)(CC)[C@H](C)C[C@@H]5C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N20 compound treatment 226680.0 111000.0 0.95 101560.0 2710.0 0.02 0.6854 0.7237 1357 SPBio_001558 CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N21 compound treatment 198360.0 82900.0 0.71 92960.0 -5890.0 -0.05 0.4646 0.6568 1000111 SPBio_001559 OC(=O)CCCCC1SCC2NC(=O)NC12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N22 compound treatment 201760.0 86300.0 0.73 72280.0 -26600.0 -0.22 0.3641 0.4748 864 SPBio_001560 Oc1noc2CNCCc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N23 mock treatment 186040.0 70600.0 0.6 66760.0 -32100.0 -0.27 0.2372 0.3611 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 N24 mock treatment 129320.0 13900.0 0.12 60360.0 -38500.0 -0.32 -0.1417 -0.4175 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O01 mock treatment 100720.0 -14700.0 -0.13 64600.0 -34200.0 -0.28 -0.2891 -0.933 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O02 mock treatment 184720.0 69300.0 0.59 89600.0 -9250.0 -0.08 0.3628 0.6103 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O03 compound treatment 200640.0 85200.0 0.73 62440.0 -36400.0 -0.3 0.2998 0.3818 1407 SPBio_001561 NC(COCc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O04 compound treatment 233480.0 118000.0 1.0 53000.0 -45800.0 -0.38 0.4423 0.4118 1237 SPBio_001562 CC(=O)Nc1ccc(OC(=O)c2ccccc2O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O05 compound treatment 236840.0 121000.0 1.03 69040.0 -29800.0 -0.25 0.5564 0.5237 1026 SPBio_001563 CC(=O)NC(Cc1ccccc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O06 compound treatment 229760.0 114000.0 0.97 61760.0 -37100.0 -0.31 0.4711 0.4618 821 SPBio_001564 O=C1NS(=O)(=O)c2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O07 compound treatment 243120.0 128000.0 1.09 45240.0 -53600.0 -0.44 0.4549 0.3876 987 SPBio_001565 CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O08 compound treatment 251440.0 136000.0 1.16 40400.0 -58400.0 -0.48 0.4767 0.38 1122 SPBio_001566 N(=Nc1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O09 compound treatment 258280.0 143000.0 1.22 35720.0 -63100.0 -0.52 0.4905 0.3707 874 SPBio_001567 CC(C)CC(NC(=O)CCN)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O10 compound treatment 262600.0 147000.0 1.25 72000.0 -26800.0 -0.22 0.7288 0.5728 738 SPBio_001568 CC(=O)Nc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O11 compound treatment 261680.0 146000.0 1.24 99240.0 393.0 0.0 0.8826 0.709 2060457 SPBio_001569 COc1cc(O)c2c(=O)cc(oc2c1)c3ccc(O)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O12 compound treatment 127120.0 11700.0 0.1 29120.0 -69700.0 -0.58 -0.3377 -0.577 684 SPBio_001570 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(=O)CC)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O13 compound treatment 174960.0 59500.0 0.51 89120.0 -9730.0 -0.08 0.3013 0.5874 1006104 SPBio_001571 Cc1cc(=O)oc2cc(O)cc(O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O14 compound treatment 15480.0 -100000.0 -0.85 6120.0 -92700.0 -0.77 -1.1444 -0.9986 3059431 SPBio_001572 CCC(=O)O[C@H]1CCC2C3CCc4cc(O)ccc4C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O15 compound treatment 262520.0 147000.0 1.25 63200.0 -35600.0 -0.29 0.6768 0.5262 2060475 SPBio_001573 COc1cc(OC)c2C(=O)CC(Oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O16 compound treatment 43840.0 -71600.0 -0.61 6360.0 -92500.0 -0.77 -0.9723 -0.9937 813 SPBio_001574 CC(=O)O[C@H]1CCC2C3CCc4cc(OC(=O)C)ccc4C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O17 compound treatment 299840.0 184000.0 1.57 41000.0 -57800.0 -0.48 0.7716 0.4702 2060277 SPBio_001575 COc1cccc2c(=O)c(OC)c(oc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O18 compound treatment 213080.0 97600.0 0.83 26480.0 -72400.0 -0.6 0.1643 0.1605 3177458 SPBio_001576 CC(=O)Oc1ccc2C3CC[C@@]4(C)C(CCC4=O)C3CCc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O19 compound treatment 191040.0 75600.0 0.64 67120.0 -31700.0 -0.26 0.2694 0.3877 1554635 SPBio_001577 COc1cc(OC)c2c(=O)cc(oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O20 compound treatment 14640.0 -101000.0 -0.86 6040.0 -92800.0 -0.77 -1.1499 -0.9984 773 SPBio_001578 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O21 compound treatment 236160.0 121000.0 1.03 94320.0 -4530.0 -0.04 0.7001 0.6809 724 SPBio_001579 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O22 compound treatment 178680.0 63200.0 0.54 55080.0 -43800.0 -0.36 0.1245 0.192 782 SPBio_001580 CC1(C)O[C@@H]2CC3C4C[C@H](F)C5=CC(=O)C=CC5(C)C4C(O)CC3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O23 mock treatment 179360.0 63900.0 0.54 108920.0 10100.0 0.08 0.4436 0.806 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 O24 mock treatment 123280.0 7810.0 0.07 48120.0 -50700.0 -0.42 -0.2497 -0.5877 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P01 mock treatment 38920.0 -76500.0 -0.65 66480.0 -32400.0 -0.27 -0.6502 -0.9228 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P02 mock treatment 84880.0 -30600.0 -0.26 75160.0 -23700.0 -0.2 -0.3227 -0.9902 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P03 compound treatment 109600.0 -5870.0 -0.05 69240.0 -29600.0 -0.24 -0.2085 -0.8342 1255 SPBio_001581 NC(=O)c1ccc(cc1Cl)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P04 compound treatment 141160.0 25700.0 0.22 43320.0 -55500.0 -0.46 -0.1701 -0.3344 1419 SPBio_001582 NCCSSCCN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P05 compound treatment 150800.0 35300.0 0.3 27320.0 -71500.0 -0.59 -0.2057 -0.3099 1263 SPBio_001583 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P06 compound treatment 266360.0 151000.0 1.28 43040.0 -55800.0 -0.46 0.582 0.4263 1524 SPBio_001584 CC(C)Nc1c(C)n(C)n(c2ccccc2)c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P07 compound treatment 309840.0 194000.0 1.65 37960.0 -60900.0 -0.5 0.814 0.4706 1424 SPBio_001585 CCCC(=O)Nc1ncnc2n(cnc12)C3O[C@@H]4COP(=O)(O)O[C@H]4[C@H]3OC(=O)CCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P08 compound treatment 54520.0 -60900.0 -0.52 23160.0 -75700.0 -0.63 -0.8097 -0.9956 1452 SPBio_001586 CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P09 compound treatment 253720.0 138000.0 1.18 41800.0 -57000.0 -0.47 0.4986 0.3932 1246 SPBio_001587 CC[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P10 compound treatment 228480.0 113000.0 0.96 38400.0 -60400.0 -0.5 0.3268 0.3014 1493 SPBio_001588 CCC(=O)O[C@@]1([C@@H](C)CC2C3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P11 compound treatment 286080.0 171000.0 1.45 57320.0 -41500.0 -0.34 0.7842 0.5254 1299 SPBio_001589 Nc1ccc(cc1)C(=O)NCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P12 compound treatment 331600.0 216000.0 1.84 120760.0 21900.0 0.18 1.4294 0.773 1526 SPBio_001590 CC1CCCC(C)N1NC(=O)c2ccc(Cl)c(c2)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P13 compound treatment 10400.0 -105000.0 -0.89 4600.0 -94200.0 -0.78 -1.1839 -0.9977 1387 SPBio_001591 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P14 compound treatment 52560.0 -62900.0 -0.54 7240.0 -91600.0 -0.76 -0.9146 -0.9856 1431 SPBio_001592 Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P15 compound treatment 230560.0 115000.0 0.98 45720.0 -53100.0 -0.44 0.3821 0.3558 872 SPBio_001593 CCN(CC)CCOC(=O)C(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P16 compound treatment 177720.0 62300.0 0.53 32640.0 -66200.0 -0.55 -0.0125 -0.0164 3045655 SPBio_001594 CC(=O)[C@@]1(O)CCC2C3C=C(Cl)C4=CC(=O)[C@@H]5CC5[C@]4(C)C3CC[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P17 compound treatment 189520.0 74100.0 0.63 30320.0 -68500.0 -0.57 0.045 0.053 701 SPBio_001595 Nc1c(Br)cc(Br)cc1CNC2CCC(O)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P18 compound treatment 247960.0 132000.0 1.13 31400.0 -67400.0 -0.56 0.4031 0.3203 3172846 SPBio_001596 NC(CO)(CO)CO.OC(=O)C1CCn2c(ccc12)C(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P19 compound treatment 235880.0 120000.0 1.03 46720.0 -52100.0 -0.43 0.42 0.3776 3174106 SPBio_001597 CN(C)CCCO[C@H]1[C@H](OC2OC(C)(C)O[C@H]12)C(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P20 compound treatment 138200.0 22700.0 0.19 39080.0 -59800.0 -0.49 -0.2128 -0.4007 1453 SPBio_001598 CN1CCCN=C1/C=C/c2sccc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P21 compound treatment 165560.0 50100.0 0.43 66720.0 -32100.0 -0.27 0.1136 0.2261 818 SPBio_001599 CCC1(CC)C(=O)NC=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P22 compound treatment 84720.0 -30700.0 -0.26 75200.0 -23600.0 -0.2 -0.3235 -0.9897 1461 SPBio_001600 CN1CCCN=C1COC(=O)C(O)(C2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P23 mock treatment 69600.0 -45900.0 -0.39 82560.0 -16300.0 -0.13 -0.3714 -0.8991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2162 P24 mock treatment 52200.0 -63300.0 -0.54 54360.0 -44500.0 -0.37 -0.6411 -0.9827 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A01 mock treatment 53640.0 -18800.0 -0.16 100920.0 -31600.0 -0.26 -0.298 -0.972 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A02 mock treatment 98000.0 25600.0 0.22 118360.0 -14200.0 -0.12 0.0711 0.2871 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A03 compound treatment 127440.0 55000.0 0.47 114520.0 -18000.0 -0.15 0.2258 0.4593 3045683 SPBio_001601 C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A04 compound treatment 34880.0 -37500.0 -0.32 23400.0 -109000.0 -0.9 -0.8644 -0.9025 3177591 SPBio_001602 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](OC(=O)C)c4cc5OCOc5cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A05 compound treatment 8760.0 -63700.0 -0.54 4320.0 -128000.0 -1.06 -1.1333 -0.9514 1465 SPBio_001603 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A06 compound treatment 238600.0 166000.0 1.41 69720.0 -62800.0 -0.52 0.633 0.4199 2475 SPBio_001604 CC(=CC1C(C(=O)O)C1(C)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A07 compound treatment 189080.0 117000.0 0.99 18320.0 -114000.0 -0.94 0.0342 0.025 1489 SPBio_001605 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A08 compound treatment 180800.0 108000.0 0.92 56560.0 -76000.0 -0.63 0.2081 0.1863 1013144 SPBio_001606 O=C1OC(=O)C2C3CCC(O3)C21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A09 compound treatment 180680.0 108000.0 0.92 44160.0 -88400.0 -0.73 0.1348 0.1146 1459 SPBio_001607 OC1CCN(CCCN2c3ccccc3Sc4ccc(C#N)cc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A10 compound treatment 228760.0 156000.0 1.33 60720.0 -71800.0 -0.59 0.5211 0.3575 3059791 SPBio_001608 Nc1nc(cs1)/C(=C/CC(=O)O)/C(=O)N[C@H]2[C@H]3SCC=C(N3C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A11 compound treatment 254160.0 182000.0 1.55 95840.0 -36700.0 -0.3 0.8795 0.5577 1495 SPBio_001609 OC(=O)CCCCC1CCSS1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A12 compound treatment 220720.0 148000.0 1.26 119680.0 -12900.0 -0.11 0.8176 0.6452 3059465 SPBio_001610 Nc1nc(cs1)/C(=N/O)/C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A13 compound treatment 175680.0 103000.0 0.88 47240.0 -85300.0 -0.71 0.1227 0.1088 1317 SPBio_001611 Fc1ccc(cc1)C(c2ccccc2)(c3ccccc3F)n4ccnc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A14 compound treatment 121520.0 49100.0 0.42 10400.0 -122000.0 -1.01 -0.4189 -0.383 3480112 SPBio_001612 CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A15 compound treatment 245360.0 173000.0 1.47 74360.0 -58200.0 -0.48 0.7009 0.4524 1605 SPBio_001613 OC(Cn1cncn1)(Cn2cncn2)c3ccc(F)cc3F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A16 compound treatment 215480.0 143000.0 1.22 64440.0 -68100.0 -0.56 0.4629 0.3449 3079224 SPBio_001614 COC1=C(O)C(=O)c2c(O)c3c(O)c(oc3cc2C1=O)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A17 compound treatment 222480.0 150000.0 1.28 68880.0 -63700.0 -0.53 0.5311 0.3843 839435 SPBio_001615 NCCCCNC(=N)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A18 compound treatment 250560.0 178000.0 1.52 58800.0 -73700.0 -0.61 0.6411 0.3922 3079225 SPBio_001616 OC(=O)CCC1NCC2CC1CN3CCCCC23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A19 compound treatment 212840.0 140000.0 1.2 100520.0 -32000.0 -0.26 0.6581 0.5374 3250 SPBio_001617 CCCCCCCCCCCCCCCCCCOCC(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A20 compound treatment 193800.0 121000.0 1.03 97920.0 -34600.0 -0.29 0.5283 0.4925 1592184 SPBio_001618 O=C1CCCC2C3CC(CN21)[C@@H]4CCCCN4C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A21 compound treatment 130360.0 58000.0 0.49 74480.0 -58100.0 -0.48 0.0092 0.0134 1537011 SPBio_001619 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A22 compound treatment 98480.0 26100.0 0.22 120080.0 -12500.0 -0.1 0.084 0.3433 3079226 SPBio_001620 C1CN2Cc3ccccc3N=C2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A23 mock treatment 74240.0 1830.0 0.02 98720.0 -33800.0 -0.28 -0.1869 -0.6667 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 A24 mock treatment 28960.0 -43500.0 -0.37 141800.0 9250.0 0.08 -0.2075 -0.5492 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B01 mock treatment 110400.0 38000.0 0.32 133240.0 691.0 0.01 0.2328 0.7195 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B02 mock treatment 170240.0 97800.0 0.83 103800.0 -28700.0 -0.24 0.4208 0.4858 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B03 compound treatment 157880.0 85500.0 0.73 111680.0 -20900.0 -0.17 0.3925 0.5248 2060222 SPBio_001621 C/C/1=C\CCC(=O)C2CC(C)(C)C2CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B04 compound treatment 199080.0 127000.0 1.08 73120.0 -59400.0 -0.49 0.415 0.3501 2515 SPBio_001622 CCCCCCC(C)OC(=O)COc1cc(Cl)c(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B05 compound treatment 104880.0 32500.0 0.28 51560.0 -81000.0 -0.67 -0.2783 -0.3839 1099943 SPBio_001623 COc1c2C=CC(C)(C)Oc2c(CC=C(C)C)c3oc(=O)c(c(O)c13)c4ccc(O)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B06 compound treatment 14840.0 -57600.0 -0.49 6600.0 -126000.0 -1.04 -1.0834 -0.9408 2517 SPBio_001624 CC(C)N(C(=O)CCl)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B07 compound treatment 205000.0 133000.0 1.13 47800.0 -84700.0 -0.7 0.3025 0.2276 2060382 SPBio_001625 C/C/1=C\CC(C)(C)\C=C\CC2(C)OC2CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B08 compound treatment 231840.0 159000.0 1.36 57200.0 -75300.0 -0.62 0.5191 0.3475 2518 SPBio_001626 CCCCSP(=O)(SCCCC)SCCCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B09 compound treatment 247880.0 175000.0 1.49 60080.0 -72500.0 -0.6 0.6325 0.3929 1981222 SPBio_001627 CCN1CCN(C(=O)NC(C(=O)NC2C3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4C)c5ccc(O)cc5)C(=O)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B10 compound treatment 258760.0 186000.0 1.59 70560.0 -62000.0 -0.51 0.7593 0.4554 2519 SPBio_001628 CC(C)N(C(C)C)C(=O)SCC(=C(Cl)Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B11 compound treatment 264920.0 193000.0 1.64 129680.0 -2870.0 -0.02 1.1422 0.6968 3174236 SPBio_001629 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3cc(O)c(O)c4c(=O)c(O)cc(cc34)[C@H]5Oc6cc(O)cc(O)c6C[C@H]5O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B12 compound treatment 135400.0 63000.0 0.54 106160.0 -26400.0 -0.22 0.2249 0.3883 2479 SPBio_001630 CCOP(=S)(OCC)Oc1ccc2c(C)c(Cl)c(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B13 compound treatment 229240.0 157000.0 1.34 166080.0 33500.0 0.28 1.1403 0.8361 2060221 SPBio_001631 COc1ccc(cc1)[C@H]2Oc3cc(OC)cc(OC)c3C[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B14 compound treatment 220160.0 148000.0 1.26 99280.0 -33300.0 -0.28 0.6949 0.5396 2480 SPBio_001632 COP(=S)(OC)SCn1nnc2ccccc2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B15 compound treatment 148880.0 76500.0 0.65 45720.0 -86800.0 -0.72 -0.0475 -0.049 2060258 SPBio_001633 CC(=O)O[C@H]1Cc2c(OC(=O)C)cc(OC(=O)C)cc2O[C@@H]1c3ccc(OC(=O)C)c(OC(=O)C)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B16 compound treatment 239520.0 167000.0 1.42 68280.0 -64300.0 -0.53 0.6301 0.4149 2513 SPBio_001634 OC(=O)CNCP(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B17 compound treatment 230240.0 158000.0 1.34 61680.0 -70900.0 -0.59 0.5357 0.3654 2060256 SPBio_001635 CC(=CC1C(CO)C1(C)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B18 compound treatment 194840.0 122000.0 1.04 72400.0 -60100.0 -0.5 0.3852 0.3335 2514 SPBio_001636 CCCCCCC(C)OC(=O)COc1ccc(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B19 compound treatment 225440.0 153000.0 1.3 94560.0 -38000.0 -0.31 0.6991 0.5216 1952709 SPBio_001637 COc1ccc2c(C)cc(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B20 compound treatment 214040.0 142000.0 1.21 95240.0 -37300.0 -0.31 0.6344 0.5097 2478 SPBio_001638 COP(=S)(OC)Oc1ccc(cc1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B21 compound treatment 142360.0 70000.0 0.6 69040.0 -63500.0 -0.53 0.0496 0.0625 1000110 SPBio_001639 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B22 compound treatment 151960.0 79600.0 0.68 110000.0 -22500.0 -0.19 0.347 0.494 2512 SPBio_001640 COC(=O)COc1cc(Cl)c(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B23 mock treatment 145240.0 72800.0 0.62 117520.0 -15000.0 -0.12 0.3506 0.5543 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 B24 mock treatment 35960.0 -36500.0 -0.31 155880.0 23300.0 0.19 -0.083 -0.227 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C01 mock treatment 110320.0 37900.0 0.32 113160.0 -19400.0 -0.16 0.1148 0.3186 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C02 mock treatment 142320.0 69900.0 0.6 148600.0 16100.0 0.13 0.5148 0.8441 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C03 compound treatment 13280.0 -59100.0 -0.5 8720.0 -124000.0 -1.02 -1.0804 -0.9465 3172723 SPBio_001641 CC(=O)OC[C@@]1(O)C[C@@]2(C[C@H]1CCC23)CCC4c5ccoc5CC[C@@]43C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C04 compound treatment 159360.0 87000.0 0.74 94680.0 -37900.0 -0.31 0.302 0.3756 3198437 SPBio_001642 C[N+](C)(C)CCOP(=O)(O)OP(=O)(O)OC[C@H]1OC([C@H](O)[C@@H]1O)n2ccc(N)nc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C05 compound treatment 103560.0 31200.0 0.27 74000.0 -58500.0 -0.48 -0.155 -0.2806 1978 SPBio_001643 OC(=O)/C=C/c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C06 compound treatment 233280.0 161000.0 1.37 135440.0 2890.0 0.02 0.9854 0.7193 3079227 SPBio_001644 [O-][N+](=O)/N=C/1\NCCN1Cc2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C07 compound treatment 223280.0 151000.0 1.28 68400.0 -64100.0 -0.53 0.5331 0.3835 2060330 SPBio_001645 OC[C@H](O)[C@@H](O)[C@H](O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)[C@H](O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C08 compound treatment 240400.0 168000.0 1.43 75960.0 -56600.0 -0.47 0.6804 0.4521 3079228 SPBio_001646 CCNC(=O)CC[C@H](N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C09 compound treatment 192760.0 120000.0 1.02 46080.0 -86500.0 -0.72 0.2188 0.175 2060332 SPBio_001647 OC/C=C/c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C10 compound treatment 23280.0 -49100.0 -0.42 16320.0 -116000.0 -0.96 -0.9757 -0.9305 3076175 SPBio_001648 COc1cc(ccc1O)[C@H]2Oc3cc(ccc3O[C@@H]2CO)[C@H]4Oc5cc(O)cc(O)c5C(=O)[C@@H]4O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C11 compound treatment 242400.0 170000.0 1.45 111240.0 -21300.0 -0.18 0.8988 0.6164 907149 SPBio_001649 CN(C)c1nc(N)c(nc1Cl)C(=O)NC(=N)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C12 compound treatment 258160.0 186000.0 1.58 158800.0 26300.0 0.22 1.2719 0.7967 3198531 SPBio_001650 COc1ccc(cc1)c2oc3c(CC=C(C)C)c(O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)cc(O)c3c(=O)c2O[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C13 compound treatment 233480.0 161000.0 1.37 177840.0 45300.0 0.37 1.2347 0.8685 1316 SPBio_001651 CC(C)(C)NCC(O)c1ccccc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C14 compound treatment 196600.0 124000.0 1.06 113360.0 -19200.0 -0.16 0.6354 0.5943 1672 SPBio_001652 OC(=O)CCc1nc(c(o1)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C15 compound treatment 96840.0 24400.0 0.21 74720.0 -57800.0 -0.48 -0.1912 -0.3665 2060337 SPBio_001653 COc1ccc(cc1O)c2oc3cc(O[C@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)c(OC)c(O)c3c(=O)c2OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C16 compound treatment 184040.0 112000.0 0.95 61560.0 -71000.0 -0.59 0.2568 0.2299 1045397 SPBio_001654 COc1ccc(cc1OC)c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C17 compound treatment 44160.0 -28300.0 -0.24 10280.0 -122000.0 -1.01 -0.8853 -0.8515 2060338 SPBio_001655 CC(C)c1ccc2c(CC[C@H]3C4=C(CC[C@@]32C)C(=O)OC4)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C18 compound treatment 183480.0 111000.0 0.95 73080.0 -59500.0 -0.49 0.3208 0.301 1034727 SPBio_001656 COc1ccc(cc1)c2cc(=O)c3c(OC)c(OC)c(OC)c(OC)c3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C19 compound treatment 207120.0 135000.0 1.15 117320.0 -15200.0 -0.13 0.7219 0.6257 2060340 SPBio_001657 CC(=O)/C(=C\c1ccccc1)/CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C20 compound treatment 181200.0 109000.0 0.93 72640.0 -59900.0 -0.5 0.3045 0.2899 351 SPBio_001658 CC(C)NCC(O)COc1cccc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C21 compound treatment 9560.0 -62900.0 -0.54 6680.0 -126000.0 -1.04 -1.1147 -0.9521 1020994 SPBio_001659 COc1c(O)cc2oc3cc(O)c(CC=C(C)C)c(O)c3c(=O)c2c1CC=C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C22 compound treatment 109200.0 36800.0 0.31 79680.0 -52900.0 -0.44 -0.0878 -0.1632 2660 SPBio_001660 CCN(C(=O)/C=C/C)c1ccccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C23 mock treatment 124200.0 51800.0 0.44 119040.0 -13500.0 -0.11 0.2328 0.5117 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 C24 mock treatment 17160.0 -55300.0 -0.47 152240.0 19700.0 0.16 -0.2174 -0.4368 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D01 mock treatment 83000.0 10600.0 0.09 70680.0 -61900.0 -0.51 -0.2982 -0.5737 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D02 mock treatment 105480.0 33100.0 0.28 91760.0 -40800.0 -0.34 -0.0395 -0.0899 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D03 compound treatment 113640.0 41200.0 0.35 87560.0 -45000.0 -0.37 -0.0149 -0.0292 2060195 SPBio_001661 CC1(C)CC23C1CCC3(C)C(O)CCC2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D04 compound treatment 180480.0 108000.0 0.92 104920.0 -27600.0 -0.23 0.489 0.5158 2510 SPBio_001662 COC(=O)COc1ccc(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D05 compound treatment 205000.0 133000.0 1.13 129640.0 -2910.0 -0.02 0.7812 0.6919 2060197 SPBio_001663 COC1(C)CCC2OC2(C)CCC3C1CC3(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D06 compound treatment 245680.0 173000.0 1.48 167960.0 35400.0 0.29 1.2503 0.8313 2511 SPBio_001664 COC(=O)CCCOc1ccc(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D07 compound treatment 229040.0 157000.0 1.33 97160.0 -35400.0 -0.29 0.736 0.539 2069257 SPBio_001665 CC1(C)CC2C1CCC(=C)C(O)CCC2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D08 compound treatment 181040.0 109000.0 0.92 70720.0 -61800.0 -0.51 0.2923 0.2766 2509 SPBio_001666 CCc1cccc(CC)c1N(COC)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D09 compound treatment 217680.0 145000.0 1.24 94600.0 -37900.0 -0.31 0.6526 0.5114 2060199 SPBio_001667 CC1(C)CC2C1CCC3(C)OC2(C)CCC3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D10 compound treatment 230040.0 158000.0 1.34 85760.0 -46800.0 -0.39 0.6753 0.4835 2507 SPBio_001668 OC(=O)CCCOc1ccc(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D11 compound treatment 232160.0 160000.0 1.36 149480.0 16900.0 0.14 1.0608 0.7758 2060200 SPBio_001669 CC12CCC3C(CC3(C)C)C(C)(O)CCC2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D12 compound treatment 234560.0 162000.0 1.38 212240.0 79700.0 0.66 1.4424 0.9428 2506 SPBio_001670 OC(=O)COc1ccc(Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D13 compound treatment 249280.0 177000.0 1.51 195360.0 62800.0 0.52 1.4323 0.8991 2060202 SPBio_001671 CC1(C)CC2C1CCC3(C)OC2(C)CCC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D14 compound treatment 222240.0 150000.0 1.28 140840.0 8290.0 0.07 0.9506 0.7441 2481 SPBio_001672 CCOP(=S)(OCC)SCCSCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D15 compound treatment 84520.0 12100.0 0.1 35160.0 -97400.0 -0.81 -0.4968 -0.6116 2060204 SPBio_001673 CC(=O)OC1CC(C)(C)C2CCC3(C)CC12CCC3OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D16 compound treatment 239960.0 168000.0 1.43 108320.0 -24200.0 -0.2 0.867 0.6018 2482 SPBio_001674 CCOC(=O)/C=C(\C)/OP(=O)(OC)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D17 compound treatment 186080.0 114000.0 0.97 85560.0 -47000.0 -0.39 0.4095 0.3926 2060219 SPBio_001675 CC(=O)OC/1CCC(=C)[C@H]2CC(C)(C)[C@@H]2C\C=C1/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D18 compound treatment 228360.0 156000.0 1.33 107360.0 -25200.0 -0.21 0.7916 0.5889 2483 SPBio_001676 COP(=O)(OC)OC(Br)C(Cl)(Cl)Br 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D19 compound treatment 142720.0 70300.0 0.6 80000.0 -52500.0 -0.43 0.1159 0.1567 2060264 SPBio_001677 C[C@@H]1CC[C@]2(CCC3(C)[C@]4(OC2=O)C=CC5[C@@]6(C)CC[C@H](O)C(C)(C)C6CC[C@]53C)C4[C@H]1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D20 compound treatment 185640.0 113000.0 0.96 123680.0 -8870.0 -0.07 0.6298 0.6514 2485 SPBio_001678 CCS(=O)CCSP(=O)(OC)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D21 compound treatment 9600.0 -62800.0 -0.53 8120.0 -124000.0 -1.03 -1.106 -0.9535 2060266 SPBio_001679 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC(=O)C4[C@@]5(C)CC[C@H](OC(=O)C)C(C)(C)C5CC[C@]43C)C2[C@H]1C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D22 compound treatment 114800.0 42400.0 0.36 109880.0 -22700.0 -0.19 0.1226 0.3014 2490 SPBio_001680 CCOP(=S)(OCC)SCSCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D23 mock treatment 110600.0 38200.0 0.33 107440.0 -25100.0 -0.21 0.083 0.2152 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 D24 mock treatment 35480.0 -36900.0 -0.31 105400.0 -27100.0 -0.22 -0.3811 -0.9864 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E01 mock treatment 134240.0 61800.0 0.53 60480.0 -72100.0 -0.6 -0.0493 -0.062 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E02 mock treatment 95560.0 23200.0 0.2 84120.0 -48400.0 -0.4 -0.1439 -0.3223 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E03 compound treatment 134760.0 62400.0 0.53 112520.0 -20000.0 -0.17 0.2582 0.4643 3172852 SPBio_001681 CC1(C)CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)[C@@](C)(CO)C5CC[C@]43C)C2C1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E04 compound treatment 181720.0 109000.0 0.93 169160.0 36600.0 0.3 0.8723 0.8912 3079229 SPBio_001682 CC1(C)C2CC(O)C(C)(O)CC21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E05 compound treatment 12960.0 -59500.0 -0.51 9360.0 -123000.0 -1.02 -1.0785 -0.9478 3172853 SPBio_001683 C[C@@H]1OC(O[C@@H]2[C@@H](O)[C@@H](O)COC2O[C@H]3CC[C@@]4(C)C(CC[C@]5(C)C4CC=C6C7CC(C)(C)CC[C@@]7(CC[C@]65C)C(=O)O)[C@]3(C)CO)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E06 compound treatment 190720.0 118000.0 1.01 132440.0 -109.0 0.0 0.7117 0.7065 1053060 SPBio_001684 COc1ccc(cc1OC)c2oc3ccccc3c(=O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E07 compound treatment 245600.0 173000.0 1.47 137720.0 5170.0 0.04 1.0729 0.7273 2060345 SPBio_001685 C[C@@H]1OC(O[C@H]2[C@H](O)[C@@H](O)[C@H](OC[C@H]3O[C@@H](OC(=O)[C@@]45CCC(C)(C)CC5C6=CCC7[C@@]8(C)CC[C@H](OC9OC[C@H](O)[C@H](O)[C@H]9OC%10O[C@@H](C)[C@H](O)[C@@H](O)[C@H]%10O)[C@@](C)(CO)C8CC[C@@]7(C)[C@]6(C)CC4)[C@H](O)[C@@H](O)[C@@H]3O)O[C@@H]2CO)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E08 compound treatment 207560.0 135000.0 1.15 88600.0 -43900.0 -0.36 0.5566 0.4612 1864491 SPBio_001686 COc1ccc(cc1)c2coc3cc(OC)cc(OC)c3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E09 compound treatment 18120.0 -54300.0 -0.46 9680.0 -123000.0 -1.02 -1.0456 -0.9364 829 SPBio_001687 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E10 compound treatment 162600.0 90200.0 0.77 119760.0 -12800.0 -0.11 0.4682 0.604 3198532 SPBio_001688 COC(=O)Nc1nc2ccc(cc2[nH]1)S(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E11 compound treatment 209360.0 137000.0 1.17 124360.0 -8190.0 -0.07 0.7766 0.6649 1054504 SPBio_001689 COc1c(OCC(O)C(C)(C)O)ccc2c(OC)c3ccoc3nc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E12 compound treatment 237880.0 165000.0 1.41 229760.0 97200.0 0.8 1.5649 0.9646 435 SPBio_001690 CC(C)Cn1c(=O)n(C)c(=O)c2nc[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E13 compound treatment 221240.0 149000.0 1.27 189080.0 56500.0 0.47 1.2267 0.9082 1024517 SPBio_001691 COc1cc2CCNC(C)c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E14 compound treatment 224160.0 152000.0 1.29 187160.0 54600.0 0.45 1.2331 0.9009 832325 SPBio_001692 COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E15 compound treatment 221800.0 149000.0 1.27 138280.0 5730.0 0.05 0.9329 0.733 3079221 SPBio_001693 O=c1cccc2C3CC(Cn21)[C@@H]4CCCCN4C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E16 compound treatment 133280.0 60900.0 0.52 81760.0 -50800.0 -0.42 0.0694 0.104 1099044 SPBio_001694 CC(C)(C)C(=O)C(Oc1ccc(Cl)cc1)n2cncn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E17 compound treatment 240440.0 168000.0 1.43 121040.0 -11500.0 -0.1 0.9443 0.6586 2060358 SPBio_001695 C[C@@H]1CCC2[C@](C)(CO)[C@@H](O)CC[C@]2(C)[C@]31CC[C@@](CO)(CCO)O3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E18 compound treatment 128200.0 55800.0 0.48 101520.0 -31000.0 -0.26 0.1544 0.2859 3198533 SPBio_001696 CCc1c(C)c2=Cc3c(C=C)c(C)c4C=c5c(C)c(CCC(=O)O)c6=C7C(C(=O)O)C(=O)c8c(C)c9C=c1n2[Cu](n9c78)(n43)n56 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E19 compound treatment 13680.0 -58700.0 -0.5 10240.0 -122000.0 -1.01 -1.0691 -0.9472 2060328 SPBio_001697 CC(C)CC(=O)c1c(O)c(C)c(O)c2c1oc3c(C(=O)CC(C)C)c(O)c(C)c(O)c32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E20 compound treatment 120520.0 48100.0 0.41 95320.0 -37200.0 -0.31 0.0719 0.1402 1017318 SPBio_001698 NC(=O)c1ccc(N)nc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E21 compound treatment 116760.0 44400.0 0.38 86160.0 -46400.0 -0.38 -0.0044 -0.0081 2060307 SPBio_001699 COc1ccc2[C@@H](O)[C@H](Cc3ccc(OC)c(OC)c3)COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E22 compound treatment 93680.0 21300.0 0.18 101880.0 -30700.0 -0.25 -0.0513 -0.1647 2109 SPBio_001700 OCc1c[nH]c2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E23 mock treatment 106160.0 33800.0 0.29 136920.0 4370.0 0.04 0.2288 0.7899 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 E24 mock treatment 49960.0 -22500.0 -0.19 81480.0 -51100.0 -0.42 -0.4339 -0.9357 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F01 mock treatment 152040.0 79600.0 0.68 54480.0 -78100.0 -0.65 0.0227 0.0243 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F02 mock treatment 100120.0 27700.0 0.24 76120.0 -56400.0 -0.47 -0.1633 -0.3121 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F03 compound treatment 71080.0 -1330.0 -0.01 50680.0 -81900.0 -0.68 -0.4869 -0.7188 2060268 SPBio_001701 C[C@@H]1CC[C@]2(CCC3(C)[C@]4(OC2=O)C=CC5[C@@]6(C)CCC(=O)C(C)(C)C6CC[C@]53C)C4[C@H]1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F04 compound treatment 186480.0 114000.0 0.97 150400.0 17900.0 0.15 0.7912 0.8054 2486 SPBio_001702 CNC(=O)CSP(=S)(OC)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F05 compound treatment 11680.0 -60700.0 -0.52 9800.0 -123000.0 -1.02 -1.0837 -0.951 2060270 SPBio_001703 CC(C)c1ccc2c(CCC3C(C)(CCCC32C)C(=O)N)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F06 compound treatment 128480.0 56100.0 0.48 105200.0 -27300.0 -0.23 0.1776 0.3362 2488 SPBio_001704 CCOP(=S)(OCC)SCn1c(=O)oc2cc(Cl)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F07 compound treatment 238360.0 166000.0 1.41 120480.0 -12100.0 -0.1 0.9285 0.6555 2060272 SPBio_001705 CC1CCC2C(CC2(C)C)C(=C)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F08 compound treatment 233760.0 161000.0 1.37 201840.0 69300.0 0.57 1.3767 0.9249 2489 SPBio_001706 COP(=O)(N)SC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F09 compound treatment 26160.0 -46300.0 -0.39 15640.0 -117000.0 -0.97 -0.9623 -0.9216 2060274 SPBio_001707 CC(C)C1CC=C(C)C2CC(=O)C(=CC12)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F10 compound treatment 181120.0 109000.0 0.93 74120.0 -58400.0 -0.48 0.3127 0.2995 3046265 SPBio_001708 Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F11 compound treatment 217400.0 145000.0 1.23 196640.0 64100.0 0.53 1.2478 0.9288 3053888 SPBio_001709 CC(=CCC[C@](C)(OC(=O)C)C1CCC(=CC1)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F12 compound treatment 234160.0 162000.0 1.38 223880.0 91300.0 0.76 1.5081 0.9601 2534 SPBio_001710 ClC(=C(c1ccc(Cl)cc1)c2ccc(Cl)cc2)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F13 compound treatment 28480.0 -43900.0 -0.37 20960.0 -112000.0 -0.92 -0.9172 -0.9209 3053889 SPBio_001711 C[C@@H]1CC[C@H]2C(C)(C)C3CC12CC[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F14 compound treatment 84280.0 11900.0 0.1 68800.0 -63700.0 -0.53 -0.3014 -0.5614 1304 SPBio_001712 ClC1=C(Cl)C2(Cl)C3C4CC(C5OC54)C3C1(Cl)C2(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F15 compound treatment 168120.0 95700.0 0.81 104880.0 -27700.0 -0.23 0.4144 0.4895 2069281 SPBio_001713 C[C@@]12CCC3C(CCc4cc(OC(=O)c5ccccc5)ccc34)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F16 compound treatment 16320.0 -56100.0 -0.48 12200.0 -120000.0 -1.0 -1.0417 -0.9434 2535 SPBio_001714 CC1(C)C(C(Cl)Cl)C2(Cl)C(Cl)C(Cl)C1(Cl)C2(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F17 compound treatment 214000.0 142000.0 1.21 175520.0 43000.0 0.36 1.1038 0.8782 3053891 SPBio_001715 OC(=O)C/C(=C\C(=O)O)/C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F18 compound treatment 123640.0 51200.0 0.44 99040.0 -33500.0 -0.28 0.1124 0.2175 2536 SPBio_001716 ClC1CC2C(C1Cl)C3(Cl)C(Cl)C(Cl)C2(Cl)C3(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F19 compound treatment 214240.0 142000.0 1.21 227360.0 94800.0 0.78 1.4085 0.9782 1045072 SPBio_001717 NC(CSCSCC(N)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F20 compound treatment 221720.0 149000.0 1.27 185480.0 52900.0 0.44 1.2086 0.8988 2520 SPBio_001718 Clc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F21 compound treatment 169320.0 96900.0 0.83 168520.0 36000.0 0.3 0.7939 0.9051 3054971 SPBio_001719 O[C@@H]1C[C@](O)(C[C@@H](O)[C@@H]1O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F22 compound treatment 9720.0 -62700.0 -0.53 12360.0 -120000.0 -0.99 -1.0805 -0.9575 2521 SPBio_001720 Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F23 mock treatment 121080.0 48700.0 0.41 149880.0 17300.0 0.14 0.3944 0.8994 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 F24 mock treatment 36840.0 -35600.0 -0.3 86240.0 -46300.0 -0.38 -0.485 -0.9932 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G01 mock treatment 96880.0 24500.0 0.21 98680.0 -33900.0 -0.28 -0.0508 -0.1455 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G02 mock treatment 120840.0 48400.0 0.41 72960.0 -59600.0 -0.49 -0.057 -0.0887 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G03 compound treatment 101720.0 29300.0 0.25 64200.0 -68300.0 -0.57 -0.2234 -0.3614 3079222 SPBio_001721 CC(=O)OC[C@H]1O[C@@H](Oc2cc(OC(=O)C)c3c(=O)cc(oc3c2)c4ccc(OC(=O)C)cc4)[C@H](OC(=O)C)[C@@H](OC(=O)C)[C@@H]1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G04 compound treatment 10880.0 -61500.0 -0.52 10120.0 -122000.0 -1.01 -1.0866 -0.9529 122 SPBio_001722 C(c1c[nH]c2ccccc12)c3c[nH]c4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G05 compound treatment 35120.0 -37300.0 -0.32 30480.0 -102000.0 -0.84 -0.8216 -0.9107 2060255 SPBio_001723 CC(=O)Oc1ccc(/C=C/c2cc(OC(=O)C)cc(OC(=O)C)c2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G06 compound treatment 215720.0 143000.0 1.22 211560.0 79000.0 0.65 1.325 0.9572 1788 SPBio_001724 NC(=O)CS(=O)C(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G07 compound treatment 185000.0 113000.0 0.96 125000.0 -7550.0 -0.06 0.6337 0.6596 3054095 SPBio_001725 CCC(/C=C/[C@@H](C)[C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G08 compound treatment 201320.0 129000.0 1.1 180120.0 47600.0 0.39 1.0544 0.9043 3304 SPBio_001726 Fc1ccc(cc1)C(=O)C2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G09 compound treatment 256520.0 184000.0 1.57 209960.0 77400.0 0.64 1.5613 0.922 3174115 SPBio_001727 CC[C@H](CCC(C)[C@H]1CCC2C3CCC4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G10 compound treatment 18200.0 -54200.0 -0.46 15280.0 -117000.0 -0.97 -1.0124 -0.9423 3055363 SPBio_001728 COc1cc(/C=C/C(=C/C(=O)\C=C\c2ccc(O)c(OC)c2)/O)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G11 compound treatment 21200.0 -51200.0 -0.44 18160.0 -114000.0 -0.95 -0.9774 -0.9381 2060290 SPBio_001729 C[C@@H]1OC(O[C@H]2CC[C@@]3(C)C(CC[C@]4(C)C3CC=C5C6CC(C)(C)CC[C@@]6(C(O)C[C@]54C)C(=O)O[C@@H]7OC[C@H](O)[C@@H](O)[C@H]7OC8O[C@@H](C)[C@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@@H](O)[C@H]8O)C2(C)C)[C@H](O)[C@H](O)[C@H]1O[C@@H]%10OC[C@@H](O)[C@H](O)[C@H]%10O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G12 compound treatment 226560.0 154000.0 1.31 227160.0 94600.0 0.78 1.4815 0.9695 1912 SPBio_001730 [O-][N+](=O)c1cccc2cn[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G13 compound treatment 208840.0 136000.0 1.16 195480.0 62900.0 0.52 1.1895 0.9345 3055472 SPBio_001731 CC(C)CCCC(C)[C@H]1CCC2C3CC[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G14 compound treatment 220200.0 148000.0 1.26 241760.0 109000.0 0.9 1.5286 0.9868 1003535 SPBio_001732 ONC(=O)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G15 compound treatment 208440.0 136000.0 1.16 221760.0 89200.0 0.74 1.3408 0.9763 3055308 SPBio_001733 COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@@H]3[C@@H](C)[C@@H](O)C[C@@H]31 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G16 compound treatment 118000.0 45600.0 0.39 119800.0 -12700.0 -0.11 0.1999 0.497 2060198 SPBio_001734 COc1ccc2C=C3c4cc(OC)c(OC)cc4OCC3(O)Oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G17 compound treatment 142760.0 70400.0 0.6 143320.0 10800.0 0.09 0.4866 0.8035 2060301 SPBio_001735 COc1ccc(cc1O)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G18 compound treatment 14680.0 -57700.0 -0.49 13960.0 -119000.0 -0.98 -1.0413 -0.9489 3198534 SPBio_001736 OCC(O)CC(O)CCCCCCCCCCCC=C.OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G19 compound treatment 181160.0 109000.0 0.93 187280.0 54700.0 0.45 0.9749 0.9459 1119359 SPBio_001737 COc1cc2ccc(=O)oc2c(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G20 compound treatment 169480.0 97100.0 0.83 180680.0 48100.0 0.4 0.866 0.9439 3198535 SPBio_001738 CC(=O)O[C@@H]1CC2C(C)(C)[C@H](O)C[C@H](O)[C@]2(C)C3CC[C@]4(C)[C@@H](OC(=O)C=C4[C@]13C)c5ccoc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G21 compound treatment 53800.0 -18600.0 -0.16 39400.0 -93100.0 -0.77 -0.6569 -0.835 3055306 SPBio_001739 C[C@@H]1CC[C@]2(CO)CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)[C@@H]2[C@H]1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G22 compound treatment 128600.0 56200.0 0.48 166520.0 34000.0 0.28 0.537 0.9678 734 SPBio_001740 CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G23 mock treatment 119760.0 47400.0 0.4 146280.0 13700.0 0.11 0.3654 0.8724 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 G24 mock treatment 21600.0 -50800.0 -0.43 112840.0 -19700.0 -0.16 -0.4212 -0.911 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H01 mock treatment 57040.0 -15400.0 -0.13 88280.0 -44300.0 -0.37 -0.3515 -0.9038 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H02 mock treatment 78280.0 5870.0 0.05 100080.0 -32500.0 -0.27 -0.1546 -0.5658 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H03 compound treatment 147040.0 74600.0 0.64 135600.0 3050.0 0.03 0.4672 0.7346 1007364 SPBio_001741 CCOC(=O)C1C(C=C(C)C)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H04 compound treatment 179280.0 107000.0 0.91 166720.0 34200.0 0.28 0.8433 0.8851 2522 SPBio_001742 CNC(=O)Oc1cccc2CC(C)(C)Oc21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H05 compound treatment 188600.0 116000.0 0.99 192680.0 60100.0 0.5 1.0513 0.9494 852250 SPBio_001743 C1CCC(NC1)c2cccnc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H06 compound treatment 218360.0 146000.0 1.24 219000.0 86500.0 0.72 1.3844 0.9656 3172728 SPBio_001744 CNC(=O)O/N=C(/C)\SC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H07 compound treatment 220800.0 148000.0 1.26 224560.0 92000.0 0.76 1.4316 0.9706 1610 SPBio_001745 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H08 compound treatment 158560.0 86200.0 0.73 106440.0 -26100.0 -0.22 0.3659 0.4786 2527 SPBio_001746 COP(=S)(OC)Oc1ccc(Sc2ccc(OP(=S)(OC)OC)cc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H09 compound treatment 202880.0 130000.0 1.11 218720.0 86200.0 0.71 1.2896 0.977 1014978 SPBio_001747 OCC(O)C(O)C(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H10 compound treatment 277680.0 205000.0 1.75 224280.0 91700.0 0.76 1.7724 0.9302 2530 SPBio_001748 CCCSP(=O)(OCC)SCCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H11 compound treatment 251600.0 179000.0 1.53 276840.0 144000.0 1.19 1.9229 0.9926 1003823 SPBio_001749 Cc1occc(=O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H12 compound treatment 211800.0 139000.0 1.19 208120.0 75600.0 0.63 1.2813 0.9552 2532 SPBio_001750 CC(C)(C)c1ccc(OC2CCCCC2OS(=O)OCC#C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H13 compound treatment 218880.0 146000.0 1.25 221600.0 89100.0 0.74 1.4027 0.9685 1052459 SPBio_001751 COc1c2ccoc2cc3oc(C)cc(=O)c13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H14 compound treatment 249360.0 177000.0 1.51 267160.0 135000.0 1.11 1.8528 0.9889 2491 SPBio_001752 COC(=O)c1c(Cl)c(Cl)c(C(=O)OC)c(Cl)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H15 compound treatment 148400.0 76000.0 0.65 199560.0 67000.0 0.55 0.8495 0.997 2069297 SPBio_001753 CC(C)CCCC(C)[C@H]1CCC2C3CC=C4C[C@H](CC[C@]4(C)C3CC[C@]12C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H16 compound treatment 148360.0 76000.0 0.65 165280.0 32700.0 0.27 0.6487 0.9253 2492 SPBio_001754 CC(C)Nc1nc(Cl)nc(NC(C)C)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H17 compound treatment 180040.0 108000.0 0.92 188280.0 55700.0 0.46 0.974 0.9495 470 SPBio_001755 OC(=O)CCCc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H18 compound treatment 186280.0 114000.0 0.97 161640.0 29100.0 0.24 0.8557 0.8566 2493 SPBio_001756 CCC(=O)Nc1ccc(Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H19 compound treatment 149240.0 76800.0 0.65 156640.0 24100.0 0.2 0.6035 0.8825 1000133 SPBio_001757 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H20 compound treatment 196760.0 124000.0 1.06 211080.0 78500.0 0.65 1.208 0.9725 2494 SPBio_001758 CCNc1nc(Cl)nc(NCC)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H21 compound treatment 193200.0 121000.0 1.03 186160.0 53600.0 0.44 1.0408 0.9293 2060499 SPBio_001759 OC[C@H]1O[C@@H](Oc2cc(O)c3c(=O)cc(oc3c2)c4ccc(O)cc4)[C@H](O[C@@H]5OC[C@](O)(CO)[C@H]5O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H22 compound treatment 146480.0 74100.0 0.63 194360.0 61800.0 0.51 0.8075 0.9946 2495 SPBio_001760 CCNc1nc(Cl)nc(NC(C)C)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H23 mock treatment 88880.0 16500.0 0.14 145680.0 13100.0 0.11 0.176 0.992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 H24 mock treatment 5040.0 -67400.0 -0.57 100760.0 -31800.0 -0.26 -0.5916 -0.9375 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I01 mock treatment 43080.0 -29300.0 -0.25 106320.0 -26200.0 -0.22 -0.33 -0.9975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I02 mock treatment 75960.0 3550.0 0.03 137160.0 4610.0 0.04 0.0483 0.9934 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I03 compound treatment 130320.0 57900.0 0.49 130560.0 -1990.0 -0.02 0.337 0.6831 2060321 SPBio_001761 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4c(=O)cc(oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I04 compound treatment 23880.0 -48500.0 -0.41 34040.0 -98500.0 -0.81 -0.8684 -0.9504 2060201 SPBio_001762 CC(=O)OCC(O)CC(O)CCCCCCCCCCCC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I05 compound treatment 202880.0 130000.0 1.11 224440.0 91900.0 0.76 1.323 0.9829 3173485 SPBio_001763 OC[C@H]1O[C@H](Oc2cccc3[C@H]([C@@H]4c5cccc(O[C@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)c5C(=O)c7c(O)cc(cc47)C(=O)O)c8cc(cc(O)c8C(=O)c23)C(=O)O)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I06 compound treatment 108040.0 35600.0 0.3 126840.0 -5710.0 -0.05 0.1811 0.5899 2069229 SPBio_001764 Oc1ccc2oc3ccccc3c(=O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I07 compound treatment 165120.0 92700.0 0.79 177880.0 45300.0 0.38 0.8233 0.9421 2060342 SPBio_001765 O[C@@H]1[C@H](Oc2cc(O)ccc2C1=O)c3cc(O)c(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I08 compound treatment 76040.0 3630.0 0.03 64560.0 -68000.0 -0.56 -0.3759 -0.6672 2060279 SPBio_001766 CC(=O)OC1CC[C@@]2(C)C(CC[C@]3(C)C2CCC4C5CC(C)(C)CCC5(CC[C@]43C)C(=O)O)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I09 compound treatment 145520.0 73100.0 0.62 198000.0 65500.0 0.54 0.823 0.9976 2060442 SPBio_001767 CCC(N)C(O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I10 compound treatment 96760.0 24400.0 0.21 101360.0 -31200.0 -0.26 -0.0358 -0.1083 2069285 SPBio_001768 CCCCCC(=O)Cc1cc(O)cc(O)c1C(=O)Oc2cc(CC(=O)CCCCC)c(C(=O)O)c(OC)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I11 compound treatment 223080.0 151000.0 1.28 240640.0 108000.0 0.89 1.5394 0.9844 2060343 SPBio_001769 CCCc1occc(=O)c1/C=C/O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I12 compound treatment 261120.0 189000.0 1.61 221440.0 88900.0 0.74 1.6561 0.9372 2524 SPBio_001770 COP(=O)(NC(=O)C)SC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I13 compound treatment 230280.0 158000.0 1.34 235080.0 103000.0 0.85 1.5502 0.9754 2060303 SPBio_001771 Cc1occc(=O)c1/C=C/O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I14 compound treatment 192720.0 120000.0 1.02 247040.0 114000.0 0.95 1.3941 0.9992 2528 SPBio_001772 CNC(=O)Oc1cccc2OC(C)(C)Oc21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I15 compound treatment 30320.0 -42100.0 -0.36 31920.0 -101000.0 -0.83 -0.8421 -0.9291 1000697 SPBio_001773 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(O[C@@H]4O[C@@H]5CO[C@H](OC5[C@H](O)[C@H]4O)c6cccs6)c7cc8OCOc8cc27 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I16 compound treatment 20200.0 -52200.0 -0.44 36360.0 -96200.0 -0.8 -0.877 -0.9622 2060192 SPBio_001774 CC1(C)CC2C1CCC3(C)CCCC2(O)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I17 compound treatment 135720.0 63300.0 0.54 209840.0 77300.0 0.64 0.8333 0.9964 1835 SPBio_001775 CCCc1nn(C)c2c(=O)[nH]c(nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I18 compound treatment 180800.0 108000.0 0.92 212440.0 79900.0 0.66 1.1199 0.9866 3079231 SPBio_001776 CC1(C)O[C@H]2CC(=O)OC[C@@]23[C@H]1CC(=O)[C@]4(C)[C@@H]3CC[C@@]5(C)[C@@H](OC(=O)[C@H]6O[C@]654)c7ccoc7 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I19 compound treatment 11440.0 -61000.0 -0.52 13960.0 -119000.0 -0.98 -1.0608 -0.9557 2060453 SPBio_001777 Clc1c(Cl)c(C#N)c(Cl)c(C#N)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I20 compound treatment 107240.0 34800.0 0.3 100760.0 -31800.0 -0.26 0.0237 0.0599 1393 SPBio_001778 CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I21 compound treatment 176360.0 104000.0 0.89 194920.0 62400.0 0.52 0.9907 0.967 2060298 SPBio_001779 CCCCCC1C(CC(=O)O)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I22 compound treatment 119160.0 46800.0 0.4 177200.0 44700.0 0.37 0.5427 0.9993 3055569 SPBio_001780 OCc1cccnc1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I23 mock treatment 103920.0 31500.0 0.27 147880.0 15300.0 0.13 0.2794 0.9415 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 I24 mock treatment 13160.0 -59300.0 -0.5 141400.0 8850.0 0.07 -0.3049 -0.5982 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J01 mock treatment 49320.0 -23100.0 -0.2 156680.0 24100.0 0.2 0.0021 0.0077 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J02 mock treatment 76720.0 4310.0 0.04 128080.0 -4470.0 -0.04 -2.0E-4 -0.0037 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J03 compound treatment 59120.0 -13300.0 -0.11 103560.0 -29000.0 -0.24 -0.2496 -0.9412 2060362 SPBio_001781 COc1ccc(cc1)c2c(OC)c3c(OC)c4C=CC(C)(C)Oc4cc3oc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J04 compound treatment 150840.0 78400.0 0.67 202040.0 69500.0 0.57 0.8787 0.9972 2497 SPBio_001782 CNC(=O)N(C)c1nnc(s1)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J05 compound treatment 116640.0 44200.0 0.38 178440.0 45900.0 0.38 0.5347 1.0 2060104 SPBio_001783 COc1cc(C)c2c(=O)c3c(O)cc(O)cc3oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J06 compound treatment 186400.0 114000.0 0.97 226640.0 94100.0 0.78 1.2367 0.994 2498 SPBio_001784 COc1c(Cl)ccc(Cl)c1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J07 compound treatment 171600.0 99200.0 0.84 263440.0 131000.0 1.08 1.3628 0.9924 1029490 SPBio_001785 COc1cc(O)c(C)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J08 compound treatment 190960.0 119000.0 1.01 227320.0 94800.0 0.78 1.2681 0.9922 2499 SPBio_001786 CCCCN(CC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J09 compound treatment 177600.0 105000.0 0.9 250160.0 118000.0 0.97 1.3213 0.9991 1060118 SPBio_001787 COc1cc(OC)c2c(=O)c(OC)c(oc2c1)c3ccc(OC)c(OC)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J10 compound treatment 188640.0 116000.0 0.99 231280.0 98700.0 0.82 1.2773 0.9955 2500 SPBio_001788 COc1nc(NC(C)C)nc(NC(C)C)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J11 compound treatment 214760.0 142000.0 1.21 269280.0 137000.0 1.13 1.6569 0.9994 2542 SPBio_001789 CCCCOC(=O)c1ccccc1C(=O)OCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J12 compound treatment 252640.0 180000.0 1.53 262400.0 130000.0 1.07 1.8447 0.9848 2501 SPBio_001790 CCc1cccc(C)c1N(C(C)COC)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J13 compound treatment 18360.0 -54100.0 -0.46 22600.0 -110000.0 -0.91 -0.9686 -0.9502 2060080 SPBio_001791 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6CC4C(=O)c3c(O)c2C=C1)C(C/C=C(/C)\C(=O)O)(OC5(C)C)C6O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J14 compound treatment 187240.0 115000.0 0.98 248320.0 116000.0 0.96 1.3686 0.9999 2502 SPBio_001792 Clc1cccc(Cl)c1C#N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J15 compound treatment 134920.0 62500.0 0.53 226960.0 94400.0 0.78 0.9286 0.9825 1471 SPBio_001793 CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J16 compound treatment 95920.0 23500.0 0.2 186120.0 53600.0 0.44 0.4549 0.9355 2503 SPBio_001794 CSc1nc(NC(C)C)nc(NC(C)C)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J17 compound treatment 123680.0 51300.0 0.44 212520.0 80000.0 0.66 0.7765 0.9796 832 SPBio_001795 CCCn1c(=O)n(CCC)c2[nH]c(nc2c1=O)C3CCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J18 compound treatment 178560.0 106000.0 0.9 247280.0 115000.0 0.95 1.3102 0.9997 2504 SPBio_001796 CCCN(CCC)c1c(cc(cc1[N+](=O)[O-])C(F)(F)F)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J19 compound treatment 10960.0 -61500.0 -0.52 15480.0 -117000.0 -0.97 -1.0548 -0.9582 3198539 SPBio_001797 CC(=CCCC1(C)Oc2c(CC=C(C)C)c3OC4(C5CC6C=C4C(=O)c3c(O)c2C=C1)C(C/C=C(\C)/C(=O)N)(OC5(C)C)C6=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J20 compound treatment 172200.0 99800.0 0.85 205800.0 73300.0 0.61 1.0293 0.9863 2505 SPBio_001798 CC(C)N1C(=O)c2ccccc2NS1(=O)=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J21 compound treatment 125760.0 53400.0 0.45 199280.0 66700.0 0.55 0.7116 0.9953 2069318 SPBio_001799 C[C@@H](NC(=O)/C(=C\c1ccc(O)c(O)c1)/C#N)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J22 compound treatment 173480.0 101000.0 0.86 232160.0 99600.0 0.82 1.1912 0.9998 2537 SPBio_001800 COc1ccc(cc1)C(c2ccc(OC)cc2)C(Cl)(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J23 mock treatment 91520.0 19100.0 0.16 182640.0 50100.0 0.41 0.4081 0.9166 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 J24 mock treatment 20200.0 -52200.0 -0.44 162600.0 30100.0 0.25 -0.1385 -0.272 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K01 mock treatment 30680.0 -41700.0 -0.36 183720.0 51200.0 0.42 0.0481 0.087 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K02 mock treatment 73520.0 1110.0 0.01 157960.0 25400.0 0.21 0.1553 0.7382 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K03 compound treatment 6400.0 -66000.0 -0.56 11680.0 -121000.0 -1.0 -1.1045 -0.9629 2060271 SPBio_001801 CCC(C)C(=O)c1c(O)c(C)c2oc3c(C)c(O)c(C(=O)C(C)CC)c(O)c3c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K04 compound treatment 102160.0 29800.0 0.25 163720.0 31200.0 0.26 0.3615 1.0 1048 SPBio_001802 CCn1cc(C(=O)O)c(=O)c2cc(F)c(nc12)N3CCNCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K05 compound treatment 49680.0 -22700.0 -0.19 76280.0 -56300.0 -0.47 -0.466 -0.9244 1386109 SPBio_001803 Oc1ccc2c(=O)c(O)c(oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K06 compound treatment 8120.0 -64300.0 -0.55 11840.0 -121000.0 -1.0 -1.0932 -0.96 709 SPBio_001804 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K07 compound treatment 77040.0 4630.0 0.04 119120.0 -13400.0 -0.11 -0.0507 -0.4299 907120 SPBio_001805 CC(N)C(=O)OC(C)(C)Cc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K08 compound treatment 152360.0 80000.0 0.68 212480.0 79900.0 0.66 0.9489 0.9999 744 SPBio_001806 Cn1cnc2[nH]c(=O)n(C)c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K09 compound treatment 83000.0 10600.0 0.09 118960.0 -13600.0 -0.11 -0.0157 -0.1092 2060459 SPBio_001807 OC[C@H]1OC2[C@@H](Oc3nc(=N)ccn23)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K10 compound treatment 177960.0 106000.0 0.9 220280.0 87700.0 0.73 1.1487 0.9944 1416 SPBio_001808 Cn1c(=O)n(C)c2[nH]c(nc2c1=O)C3CCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K11 compound treatment 196320.0 124000.0 1.06 241920.0 109000.0 0.9 1.3858 0.9971 1001314 SPBio_001809 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)[C@@H]4N[C@@H](COCCOC)O[C@H]([C@H]4C)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K12 compound treatment 230080.0 158000.0 1.34 242600.0 110000.0 0.91 1.593 0.9821 1505 SPBio_001810 CC(C)Cn1c(=O)n(C)c(=O)c2[nH]cnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K13 compound treatment 220840.0 148000.0 1.26 230520.0 98000.0 0.81 1.4667 0.9769 3474314 SPBio_001811 CN1CCCCC1C(=O)Nc2c(C)cccc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K14 compound treatment 125920.0 53500.0 0.46 225000.0 92500.0 0.76 0.863 0.9694 1587004 SPBio_001812 COc1ccc(cc1)C2Sc3ccccc3N(CCN(C)C)C(=O)C2OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K15 compound treatment 106160.0 33800.0 0.29 213440.0 80900.0 0.67 0.6764 0.9287 2060476 SPBio_001813 C[C@H]1[C@@H]2CCC(=C3[C@@H]([C@H]2OC1=O)C(=CC3=O)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K16 compound treatment 71160.0 -1250.0 -0.01 158160.0 25600.0 0.21 0.1423 0.6707 4362 SPBio_001814 CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K17 compound treatment 36960.0 -35500.0 -0.3 49840.0 -82700.0 -0.68 -0.6972 -0.9323 1095093 SPBio_001815 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K18 compound treatment 115680.0 43300.0 0.37 156800.0 24300.0 0.2 0.4024 0.9592 80 SPBio_001816 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K19 compound treatment 118640.0 46200.0 0.39 156120.0 23600.0 0.19 0.4162 0.9475 1101055 SPBio_001817 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K20 compound treatment 112320.0 39900.0 0.34 222000.0 89500.0 0.74 0.7635 0.9377 3173239 SPBio_001818 CC(N/C(=N/C#N)/Nc1ccncc1)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K21 compound treatment 11520.0 -60900.0 -0.52 17560.0 -115000.0 -0.95 -1.0392 -0.9593 2060432 SPBio_001819 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccc(O)cc5cc4Cn3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K22 compound treatment 72000.0 -410.0 0.0 154440.0 21900.0 0.18 0.1256 0.6933 1000056 SPBio_001820 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K23 mock treatment 92760.0 20400.0 0.17 145560.0 13000.0 0.11 0.1986 0.9738 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 K24 mock treatment 23960.0 -48500.0 -0.41 205160.0 72600.0 0.6 0.1331 0.1826 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L01 mock treatment 32840.0 -39600.0 -0.34 172640.0 40100.0 0.33 -0.0037 -0.0078 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L02 mock treatment 69160.0 -3250.0 -0.03 163800.0 31300.0 0.26 0.1632 0.6278 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L03 compound treatment 68400.0 -4010.0 -0.03 134280.0 1730.0 0.01 -0.014 -0.3785 3079366 SPBio_001821 O[C@@H]1[C@H]2COC(O2)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L04 compound treatment 6120.0 -66300.0 -0.56 14160.0 -118000.0 -0.98 -1.0916 -0.9657 2538 SPBio_001822 ClC1C=CC2C1C3(Cl)C(=C(Cl)C2(Cl)C3(Cl)Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L05 compound treatment 79840.0 7430.0 0.06 192200.0 59700.0 0.49 0.3937 0.7913 1516 SPBio_001823 Nc1c2CCCCc2nc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L06 compound treatment 32960.0 -39500.0 -0.34 51000.0 -81500.0 -0.67 -0.7145 -0.9481 2539 SPBio_001824 CC1(C)C2(Cl)C(Cl)C1(Cl)C(Cl)(C(Cl)Cl)C(Cl)C2Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L07 compound treatment 6320.0 -66100.0 -0.56 14080.0 -118000.0 -0.98 -1.0909 -0.9653 26 SPBio_001825 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L08 compound treatment 10960.0 -61500.0 -0.52 21360.0 -111000.0 -0.92 -1.0204 -0.9642 2541 SPBio_001826 ClC1=C(Cl)C2(Cl)C3COS(=O)OCC3C1(Cl)C2(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L09 compound treatment 101520.0 29100.0 0.25 199720.0 67200.0 0.56 0.5682 0.9338 690 SPBio_001827 CC(C)NCC(O)COc1ccccc1CC=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L10 compound treatment 15480.0 -56900.0 -0.48 28520.0 -104000.0 -0.86 -0.9513 -0.9631 2540 SPBio_001828 ClC1=C(Cl)C2(Cl)C3C4CC(C=C4)C3C1(Cl)C2(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L11 compound treatment 136960.0 64600.0 0.55 170960.0 38400.0 0.32 0.6133 0.9661 1395 SPBio_001829 CC(COc1ccccc1)N(CCCl)Cc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L12 compound treatment 202200.0 130000.0 1.11 246000.0 113000.0 0.94 1.4451 0.9967 2060152 SPBio_001830 CC(=O)O[C@@H]1CC2C(C)(C)C=CC(=O)[C@]2(C)C3CC[C@@]4(C)[C@@H](OC(=O)C5OC54[C@]13C)c6ccoc6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L13 compound treatment 198320.0 126000.0 1.07 236120.0 104000.0 0.86 1.3639 0.9938 74 SPBio_001831 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L14 compound treatment 130440.0 58000.0 0.49 236400.0 104000.0 0.86 0.9569 0.9655 3198541 SPBio_001832 CC(CCC=C(C)C)C1CC[C@@]2(C)C3=C(CC[C@]12C)C4(C)CC[C@H](OC(=O)C)C(C)(C)C4CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L15 compound treatment 99640.0 27200.0 0.23 250720.0 118000.0 0.98 0.8552 0.8512 907089 SPBio_001833 Cn1c(=O)n(C)c2ncn(CCCl)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L16 compound treatment 13120.0 -59300.0 -0.5 24160.0 -108000.0 -0.9 -0.991 -0.9631 2060174 SPBio_001834 CC(=CCc1c2OC(C)(C)C=Cc2c(O)c3c(=O)c(O)c(oc13)c4ccccc4)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L17 compound treatment 64880.0 -7530.0 -0.06 219480.0 86900.0 0.72 0.4632 0.6415 352677 SPBio_001835 COc1ccccc1N2CCNCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L18 compound treatment 109040.0 36600.0 0.31 204560.0 72000.0 0.6 0.6418 0.9544 3173763 SPBio_001836 O[C@@H]1C[C@](O)(C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H]1O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L19 compound treatment 140360.0 68000.0 0.58 217600.0 85100.0 0.7 0.9066 0.9953 718 SPBio_001837 Cn1c(=O)n(C)c2ncn(CCO)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L20 compound treatment 108160.0 35800.0 0.3 231640.0 99100.0 0.82 0.7949 0.909 1171 SPBio_001838 CC(=O)Oc1ccccc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L21 compound treatment 89120.0 16700.0 0.14 164520.0 32000.0 0.26 0.2876 0.9577 1865 SPBio_001839 Clc1cccc(Nc2nnc(c3ccccc3)c4ccccc24)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L22 compound treatment 40840.0 -31600.0 -0.27 114680.0 -17900.0 -0.15 -0.2946 -0.9603 2060217 SPBio_001840 COc1c(ccc2OC(C)(C)CCc12)C3COc4cc5OC(C)(C)C(O)Cc5cc4C3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L23 mock treatment 55960.0 -16500.0 -0.14 195400.0 62900.0 0.52 0.2686 0.4989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 L24 mock treatment 19440.0 -53000.0 -0.45 201480.0 68900.0 0.57 0.0843 0.116 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M01 mock treatment 40840.0 -31600.0 -0.27 177520.0 45000.0 0.37 0.073 0.159 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M02 mock treatment 74840.0 2430.0 0.02 167200.0 34700.0 0.29 0.2173 0.7562 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M03 compound treatment 21080.0 -51300.0 -0.44 50400.0 -82100.0 -0.68 -0.7896 -0.9772 1091368 SPBio_001841 CNc1ccccc1C(=O)N2CCc3c([nH]c4ccccc34)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M04 compound treatment 53760.0 -18700.0 -0.16 169920.0 37400.0 0.31 0.1063 0.3059 918 SPBio_001842 CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M05 compound treatment 68040.0 -4370.0 -0.04 183240.0 50700.0 0.42 0.2702 0.6418 1015899 SPBio_001843 NCC(=O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M06 compound treatment 5520.0 -66900.0 -0.57 35280.0 -97300.0 -0.8 -0.9717 -0.9857 693 SPBio_001844 CCN(CC)CCOc1ccc-2c(c1)C(=O)c3cc(OCCN(CC)CC)ccc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M07 compound treatment 63720.0 -8690.0 -0.07 208600.0 76100.0 0.63 0.3926 0.6197 1001204 SPBio_001845 COc1ccc(cc1)C(=O)CC(=O)c2ccc(cc2)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M08 compound treatment 37560.0 -34900.0 -0.3 120000.0 -12500.0 -0.1 -0.2832 -0.9009 2069286 SPBio_001846 CC(C)C(C)/C=C/C(C)[C@H]1CCC2C3=CCC4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M09 compound treatment 82120.0 9710.0 0.08 199760.0 67200.0 0.56 0.4516 0.8034 2060486 SPBio_001847 CC(=O)Oc1ccccc1C(=O)Oc2ccccc2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M10 compound treatment 8000.0 -64400.0 -0.55 20280.0 -112000.0 -0.93 -1.0445 -0.9684 3054523 SPBio_001848 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)C5CC[C@]43C)C2[C@H]1C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M11 compound treatment 25800.0 -46600.0 -0.4 56240.0 -76300.0 -0.63 -0.727 -0.975 1000656 SPBio_001849 OC1=C([C@H]2CC[C@@H](CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M12 compound treatment 209000.0 137000.0 1.16 258120.0 126000.0 1.04 1.5569 0.9984 3198536 SPBio_001850 COc1ccc2C[C@H]3N(C)CC[C@]4([C@H]5Oc1c24)C3=CC[C@@H]5O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M13 compound treatment 116360.0 44000.0 0.37 167800.0 35300.0 0.29 0.4708 0.9924 2060416 SPBio_001851 Sc1nc2ccccc2s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M14 compound treatment 127160.0 54800.0 0.47 253960.0 121000.0 1.0 1.0398 0.9391 1014978 SPBio_001852 OCC(O)C(O)C(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M15 compound treatment 66120.0 -6290.0 -0.05 262280.0 130000.0 1.07 0.721 0.671 3079223 SPBio_001853 Cl.NCCS 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M16 compound treatment 71040.0 -1370.0 -0.01 235680.0 103000.0 0.85 0.595 0.6974 3079232 SPBio_001854 COc1ccc2c(=O)ccoc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M17 compound treatment 65320.0 -7090.0 -0.06 235440.0 103000.0 0.85 0.5592 0.6553 3172732 SPBio_001855 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M18 compound treatment 54080.0 -18300.0 -0.16 125680.0 -6870.0 -0.06 -0.1505 -0.9064 3198537 SPBio_001856 CC(C)c1c(O)ccc2c1CCC3C(C)(CCCC32C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M19 compound treatment 71880.0 -530.0 0.0 111280.0 -21300.0 -0.18 -0.1276 -0.725 907181 SPBio_001857 NC(=N)NC(=O)c1nc(Cl)c(nc1N)N2CCCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M20 compound treatment 62800.0 -9610.0 -0.08 152960.0 20400.0 0.17 0.0615 0.328 1049467 SPBio_001858 COC(=O)c1c(C)cc(OC(=O)c2c(C)cc(O)c(C=O)c2O)c(C)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M21 compound treatment 83360.0 11000.0 0.09 208560.0 76000.0 0.63 0.5106 0.8032 1734308 SPBio_001859 Oc1cc(O)c2C(=O)C[C@H](Oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M22 compound treatment 40160.0 -32300.0 -0.27 145520.0 13000.0 0.11 -0.1183 -0.4012 2069239 SPBio_001860 Cc1cc(O)c2C(=O)c3c(O)c(C)cc(O)c3C(=O)c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M23 mock treatment 60920.0 -11500.0 -0.1 167840.0 35300.0 0.29 0.1373 0.4458 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 M24 mock treatment 25960.0 -46500.0 -0.4 182760.0 50200.0 0.42 0.0141 0.0245 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N01 mock treatment 59120.0 -13300.0 -0.11 178280.0 45700.0 0.38 0.1875 0.4748 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N02 mock treatment 85200.0 12800.0 0.11 198640.0 66100.0 0.55 0.4636 0.8316 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N03 compound treatment 55280.0 -17100.0 -0.15 180400.0 47900.0 0.4 0.1768 0.419 1055442 SPBio_001861 Nc1nc(O)c2nc(cnc2n1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N04 compound treatment 42520.0 -29900.0 -0.25 155840.0 23300.0 0.19 -0.0437 -0.1369 2060172 SPBio_001862 CC1(C)CC2C1CCC3(CBr)CCC4C(CC(=O)O)C(=O)OC24C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N05 compound treatment 58680.0 -13700.0 -0.12 211560.0 79000.0 0.65 0.3795 0.5716 2060299 SPBio_001863 CC1(C)CC2/C(=C/C=C/C(C)(O)CCC21O)/CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N06 compound treatment 66560.0 -5850.0 -0.05 228800.0 96300.0 0.8 0.5278 0.6616 1019872 SPBio_001864 COc1cc2COC(=O)c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N07 compound treatment 47280.0 -25100.0 -0.21 134800.0 2250.0 0.02 -0.1381 -0.6431 2069306 SPBio_001865 C[C@@]12CCC3C(CCC4=CC(=O)C=C[C@]34C)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N08 compound treatment 44440.0 -28000.0 -0.24 220800.0 88300.0 0.73 0.3478 0.453 2060193 SPBio_001866 CC1(C)C2CC1C(=C)C(N)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N09 compound treatment 75720.0 3310.0 0.03 231160.0 98600.0 0.82 0.5968 0.7311 3173755 SPBio_001867 C[C@@]12CC(=O)C3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N10 compound treatment 83880.0 11500.0 0.1 272400.0 140000.0 1.16 0.8871 0.7641 2060191 SPBio_001868 CC1(C)CC2C1CCC(=O)C(CCC2=C)C3CC(=O)OC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N11 compound treatment 102240.0 29800.0 0.25 239840.0 107000.0 0.89 0.8072 0.8744 3177324 SPBio_001869 C[C@@]12CC(=O)C3C(CC[C@@H]4C[C@H](O)CC[C@@]43C)C2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N12 compound treatment 183680.0 111000.0 0.95 255400.0 123000.0 1.02 1.3885 0.9994 1114909 SPBio_001870 COc1cc(CC=C)ccc1OC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N13 compound treatment 190160.0 118000.0 1.0 248480.0 116000.0 0.96 1.3871 0.9998 2069240 SPBio_001871 CC(=O)OCC(=O)[C@@]1(O)CCC2C3CC[C@@H]4C[C@@H](CC[C@]4(C)C3C(=O)C[C@@]21C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N14 compound treatment 130640.0 58200.0 0.5 239440.0 107000.0 0.88 0.9759 0.9626 3054634 SPBio_001872 COc1c(CC=C(C)C)c2OC(C)(C)C=Cc2c3oc(=O)c(c(O)c13)c4ccc(O)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N15 compound treatment 29680.0 -42700.0 -0.36 78600.0 -53900.0 -0.45 -0.5728 -0.9949 2060261 SPBio_001873 CC(C)(O)[C@H]1CC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@@H]2CCC4[C@@]5(C)CCCC(C)(C)C5[C@@H](O)C[C@]43C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N16 compound treatment 56080.0 -16300.0 -0.14 288600.0 156000.0 1.29 0.8145 0.6273 3174602 SPBio_001874 O=c1[nH]cnc2nc[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N17 compound treatment 50040.0 -22400.0 -0.19 217800.0 85300.0 0.71 0.364 0.4983 1506 SPBio_001875 OCc1cc(=O)c(O)co1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N18 compound treatment 16880.0 -55500.0 -0.47 93000.0 -39500.0 -0.33 -0.5657 -0.9838 3174484 SPBio_001876 C[C@@]12CCC3C(CC[C@H]4C[C@@H](O)CC[C@@]43C)C2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N19 compound treatment 75560.0 3150.0 0.03 214600.0 82100.0 0.68 0.4989 0.7345 2060349 SPBio_001877 CCC[C@H]1CC2=C(C[C@@H](CC)CC3=C1C(=O)OC3=O)C(=O)OC2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N20 compound treatment 90440.0 18000.0 0.15 192400.0 59900.0 0.5 0.4587 0.8848 2060302 SPBio_001878 CC(C)CCC[C@@H](C)CCC[C@@H](C)CC/C(=C/CO)/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N21 compound treatment 5280.0 -67100.0 -0.57 15320.0 -117000.0 -0.97 -1.0899 -0.9682 3198540 SPBio_001879 COC(=O)/C(=C/CC1(OC(C)(C)C2CC3C=C4C(=O)c5cc6C7CC(C)(CCC7=C(C)C)Oc6c(CCC(C)(C)Cl)c5OC241)C3=O)/C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N22 compound treatment 59600.0 -12800.0 -0.11 195560.0 63000.0 0.52 0.2915 0.5473 3174493 SPBio_001880 N[C@H]([C@@H](O)[C@H](O)[C@H](O)CO)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N23 mock treatment 66640.0 -5770.0 -0.05 181600.0 49100.0 0.41 0.2522 0.617 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 N24 mock treatment 48200.0 -24200.0 -0.21 160480.0 27900.0 0.23 0.0176 0.0569 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O01 mock treatment 57480.0 -14900.0 -0.13 114200.0 -18300.0 -0.15 -0.1972 -0.9961 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O02 mock treatment 67200.0 -5210.0 -0.04 229520.0 97000.0 0.8 0.5359 0.667 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O03 compound treatment 4120.0 -68300.0 -0.58 11880.0 -121000.0 -1.0 -1.117 -0.9669 1000094 SPBio_001881 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O04 compound treatment 33320.0 -39100.0 -0.33 188160.0 55600.0 0.46 0.09 0.1584 3079279 SPBio_001882 COC(=O)c1c(C)cc(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O05 compound treatment 3640.0 -68800.0 -0.59 11960.0 -121000.0 -1.0 -1.1194 -0.9678 2101 SPBio_001883 Oc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O06 compound treatment 50640.0 -21800.0 -0.19 257320.0 125000.0 1.03 0.5988 0.571 3055391 SPBio_001884 OC[C@H]1O[C@@H](Oc2cc(O)c3c(=O)cc(oc3c2)c4ccc(O)cc4)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O07 compound treatment 4240.0 -68200.0 -0.58 15600.0 -117000.0 -0.97 -1.0945 -0.9701 3480079 SPBio_001885 COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O08 compound treatment 46040.0 -26400.0 -0.22 231880.0 99300.0 0.82 0.4223 0.4957 3198538 SPBio_001886 COc1cc2OCOc2cc1c3coc4cc(OC)c(OC)cc4c3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O09 compound treatment 30920.0 -41500.0 -0.35 251520.0 119000.0 0.98 0.4462 0.4267 3177524 SPBio_001887 CC(C)[C@H]1CC[C@@H](CC1)C(=O)N[C@@H](Cc2ccccc2)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O10 compound treatment 42960.0 -29500.0 -0.25 196160.0 63600.0 0.53 0.1948 0.3342 2060249 SPBio_001888 COc1ccc(cc1)c2coc3c(OC)c(O)ccc3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O11 compound treatment 67960.0 -4450.0 -0.04 344440.0 212000.0 1.75 1.2127 0.6917 1635 SPBio_001889 CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5nnn[nH]5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O12 compound treatment 141720.0 69300.0 0.59 235520.0 103000.0 0.85 1.0196 0.9839 3079280 SPBio_001890 O[C@@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O13 compound treatment 223880.0 151000.0 1.29 314720.0 182000.0 1.51 1.9776 0.997 1000155 SPBio_001891 C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O14 compound treatment 123840.0 51400.0 0.44 256800.0 124000.0 1.03 1.0365 0.9277 1002679 SPBio_001892 OCC(O)C(O)C(O)C(O)C(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O15 compound treatment 47760.0 -24700.0 -0.21 197040.0 64500.0 0.53 0.2288 0.3992 1606766 SPBio_001893 CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)c3ccccc3c4nnn[nH]4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O16 compound treatment 43240.0 -29200.0 -0.25 232880.0 100000.0 0.83 0.4113 0.4747 2060353 SPBio_001894 Cc1c(O)cc(O)c2c(=O)c(coc12)c3ccc(O)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O17 compound treatment 42120.0 -30300.0 -0.26 118000.0 -14500.0 -0.12 -0.2675 -0.9398 3059445 SPBio_001895 CCCCCCCCCCC[C@@H](C[C@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@@H](CC(C)C)NC=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O18 compound treatment 13120.0 -59300.0 -0.5 106360.0 -26200.0 -0.22 -0.5102 -0.9287 2060132 SPBio_001896 CC1=CC(=O)C2C(C)(C)CCC[C@]2(C)[C@@]1(O)CCc3ccoc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O19 compound treatment 53280.0 -19100.0 -0.16 198680.0 66100.0 0.55 0.2717 0.4759 3480074 SPBio_001897 CCc1ccc(CCOc2ccc(CC3SC(=O)NC3=O)cc2)nc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O20 compound treatment 33520.0 -38900.0 -0.33 179440.0 46900.0 0.39 0.0402 0.0787 2060134 SPBio_001898 COc1cc2ccc(=O)oc2c3ccoc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O21 compound treatment 59640.0 -12800.0 -0.11 219200.0 86700.0 0.72 0.43 0.5931 907463 SPBio_001899 Cc1nc2ccccn2c(=O)c1CCN3CCC(CC3)C(=O)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O22 compound treatment 50960.0 -21500.0 -0.18 188320.0 55800.0 0.46 0.1971 0.3972 2060220 SPBio_001900 CC/1[C@H]2C[C@@H](C\C1=N/O)C2(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O23 mock treatment 68080.0 -4330.0 -0.04 191120.0 58600.0 0.48 0.3166 0.6514 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 O24 mock treatment 26640.0 -45800.0 -0.39 144160.0 11600.0 0.1 -0.2076 -0.5173 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P01 mock treatment 75640.0 3230.0 0.03 57760.0 -74800.0 -0.62 -0.418 -0.675 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P02 mock treatment 78040.0 5630.0 0.05 97880.0 -34700.0 -0.29 -0.1689 -0.5809 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P03 compound treatment 52280.0 -20100.0 -0.17 77280.0 -55300.0 -0.46 -0.4445 -0.9103 1087705 SPBio_001901 CCOC(=O)C1=C(O)C(=O)N(Cc2ccccc2)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P04 compound treatment 44480.0 -27900.0 -0.24 148000.0 15500.0 0.13 -0.0778 -0.288 290 SPBio_001902 CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@]2(O)[C@@H]3C=C(C)C(=O)[C@@]3(O)CC(=C[C@H]2[C@@H]4C(C)(C)[C@@]41OC(=O)C)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P05 compound treatment 2560.0 -69900.0 -0.59 8920.0 -124000.0 -1.02 -1.1437 -0.9667 2543 SPBio_001903 CCCCCCCCCc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P06 compound treatment 29800.0 -42600.0 -0.36 189560.0 57000.0 0.47 0.077 0.1293 2060293 SPBio_001904 C[C@@H]1CC[C@H]2C(C)(C)C3C[C@@]12CC[C@@]3(C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P07 compound treatment 42080.0 -30300.0 -0.26 140320.0 7770.0 0.06 -0.1371 -0.5153 2069261 SPBio_001905 COc1cc2OCC3Oc4c5C=CC(C)(C)Oc5cc(O)c4C(=O)C3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P08 compound treatment 32600.0 -39800.0 -0.34 391200.0 259000.0 2.14 1.2734 0.5878 1305 SPBio_001906 CCOC(=O)O[C@H]([C@H]1C[C@@H]2CCN1C[C@@H]2C=C)c3ccnc4ccc(OC)cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P09 compound treatment 45440.0 -27000.0 -0.23 187240.0 54700.0 0.45 0.1576 0.3105 2060403 SPBio_001907 COc1ccc(C2COc3cc(O)ccc3C2)c(OC)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P10 compound treatment 41040.0 -31400.0 -0.27 251960.0 119000.0 0.99 0.5097 0.498 2325 SPBio_001908 NC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P11 compound treatment 57320.0 -15100.0 -0.13 289560.0 157000.0 1.3 0.8276 0.6341 3079389 SPBio_001909 COc1cc(OC)c(C(=O)c2ccc(O)cc2)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P12 compound treatment 88600.0 16200.0 0.14 215240.0 82700.0 0.68 0.5812 0.8329 2544 SPBio_001910 CCOCN(C(=O)CCl)c1c(C)cccc1CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P13 compound treatment 125360.0 53000.0 0.45 264440.0 132000.0 1.09 1.0903 0.9235 2060426 SPBio_001911 COc1c(O)cccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P14 compound treatment 75360.0 2950.0 0.03 291080.0 159000.0 1.31 0.9451 0.7205 1004713 SPBio_001912 CNc1ccccc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P15 compound treatment 70160.0 -2250.0 -0.02 213960.0 81400.0 0.67 0.4627 0.6867 1402956 SPBio_001913 CC(N)C(O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P16 compound treatment 27760.0 -44700.0 -0.38 124640.0 -7910.0 -0.07 -0.3151 -0.8168 1040795 SPBio_001914 COc1cccc(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P17 compound treatment 40760.0 -31700.0 -0.27 219760.0 87200.0 0.72 0.3196 0.415 1010251 SPBio_001915 O=C(Nc1ccccc1)Nc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P18 compound treatment 37760.0 -34700.0 -0.3 256880.0 124000.0 1.03 0.5187 0.4847 2060417 SPBio_001916 CC(=C)C1Cc2c(O1)ccc(C(=O)O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P19 compound treatment 39840.0 -32600.0 -0.28 210480.0 77900.0 0.64 0.2598 0.3702 2069279 SPBio_001917 CCC(C)C(NC)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P20 compound treatment 43000.0 -29400.0 -0.25 206920.0 74400.0 0.62 0.258 0.3884 2060436 SPBio_001918 O=C(CCCCCCCCCCCCC1CCCC1)Nc2ccc(cc2)S(=O)(=O)c3ccc(NC(=O)CCCCCCCCCCCCC4CCCC4)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P21 compound treatment 10360.0 -62100.0 -0.53 65920.0 -66600.0 -0.55 -0.7633 -0.9998 2069262 SPBio_001919 COc1cc(/C=C/C=O)cc(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P22 compound treatment 52240.0 -20200.0 -0.17 90400.0 -42100.0 -0.35 -0.368 -0.9468 2060448 SPBio_001920 COc1ccc2[C@H](O)[C@H](Cc3ccc(OC)c(OC)c3)COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P23 mock treatment 62640.0 -9770.0 -0.08 114320.0 -18200.0 -0.15 -0.1655 -0.9607 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2163 P24 mock treatment 35040.0 -37400.0 -0.32 57520.0 -75000.0 -0.62 -0.6639 -0.9518 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A01 mock treatment 59920.0 -30600.0 -0.26 86560.0 -35000.0 -0.29 -0.3888 -0.9986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A02 mock treatment 112600.0 22100.0 0.19 117720.0 -3820.0 -0.03 0.1106 0.58 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A03 compound treatment 146920.0 56400.0 0.48 103160.0 -18400.0 -0.15 0.2321 0.4606 1026119 SPBio_001921 COc1ccc(C(=O)O)c(O)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A04 compound treatment 92360.0 1850.0 0.02 63080.0 -58500.0 -0.48 -0.3309 -0.6837 1164875 SPBio_001922 Nc1nc2[nH]nnc2c(=O)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A05 compound treatment 15080.0 -75400.0 -0.64 19200.0 -102000.0 -0.85 -1.0528 -0.9907 2069278 SPBio_001923 Cc1cc(O)c(C=O)c(O)c1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A06 compound treatment 253400.0 163000.0 1.39 57080.0 -64500.0 -0.53 0.6036 0.4062 923 SPBio_001924 NC(=O)NC1NC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A07 compound treatment 209720.0 119000.0 1.01 53160.0 -68400.0 -0.57 0.3177 0.2734 3080393 SPBio_001925 COc1ccc(cc1)c2c(O)c3c(OC)c4CCC(C)(C)Oc4cc3oc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A08 compound treatment 257600.0 167000.0 1.42 59560.0 -62000.0 -0.51 0.6434 0.4254 692 SPBio_001926 CC(=O)Nc1nnc(s1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A09 compound treatment 208760.0 118000.0 1.01 46720.0 -74800.0 -0.62 0.2742 0.232 2069280 SPBio_001927 COc1cc(O)ccc1C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A10 compound treatment 233120.0 143000.0 1.21 74480.0 -47100.0 -0.39 0.5833 0.4574 1714 SPBio_001928 CN(C)C(=N)NC(=N)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A11 compound treatment 224240.0 134000.0 1.14 70880.0 -50700.0 -0.42 0.5087 0.4193 2060335 SPBio_001929 Oc1ccc2C3Oc4cc5OCOc5cc4C3COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A12 compound treatment 209560.0 119000.0 1.01 129040.0 7500.0 0.06 0.7606 0.749 3221455 SPBio_001930 COc1ccc(CC2c3cc(OC)c(OC)cc3CC[N+]2(C)CCC(=O)OCCCCCOC(=O)CC[N+]4(C)CCc5cc(OC)c(OC)cc5C4Cc6ccc(OC)c(OC)c6)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A13 compound treatment 32920.0 -57600.0 -0.49 13920.0 -108000.0 -0.89 -0.9763 -0.9605 3198542 SPBio_001931 COc1ccc(cc1)c2cc(=O)c3c(OC)cc(OC)c(c4cc(ccc4OC)c5cc(=O)c6c(OC)cc(OC)cc6o5)c3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A14 compound treatment 242960.0 152000.0 1.3 98440.0 -23100.0 -0.19 0.7827 0.5965 3064163 SPBio_001932 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A15 compound treatment 197680.0 107000.0 0.91 62800.0 -58700.0 -0.49 0.3016 0.2917 3080394 SPBio_001933 COc1cc(OC)c2c(=O)c(c(C)oc2c1OC)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A16 compound treatment 239080.0 149000.0 1.26 54040.0 -67500.0 -0.56 0.4996 0.3613 1000042 SPBio_001934 NC(=N)NC(=O)c1nc(Cl)c(N)nc1N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A17 compound treatment 99040.0 8530.0 0.07 31360.0 -90200.0 -0.75 -0.4762 -0.6353 2060054 SPBio_001935 CC(=O)OC(OC(=O)C)c1c(OC(=O)C)cc(C)c2C(=O)Oc3c(C)c(OC(=O)C)c4C(=O)OC(OC(=O)C)c4c3Oc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A18 compound treatment 254560.0 164000.0 1.4 52960.0 -68600.0 -0.57 0.5865 0.389 807 SPBio_001936 CCCc1ncc(C[n+]2ccccc2C)c(N)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A19 compound treatment 239400.0 149000.0 1.27 63120.0 -58400.0 -0.48 0.5546 0.4088 3173626 SPBio_001937 CC(C)C(C)/C=C/C(C)C1CCC2C3=CC=C4C(C)(C)C(CCC4(C)C3CCC12C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A20 compound treatment 208240.0 118000.0 1.0 86960.0 -34600.0 -0.29 0.5065 0.4859 931 SPBio_001938 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A21 compound treatment 161000.0 70500.0 0.6 92560.0 -29000.0 -0.24 0.2548 0.3943 1082584 SPBio_001939 COc1cc2OCc3oc4c5CC(Oc5ccc4c(=O)c3-c2cc1OC)C(=C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A22 compound treatment 144320.0 53800.0 0.46 105800.0 -15700.0 -0.13 0.2319 0.4868 3068956 SPBio_001940 NC(=NS(=O)(=O)c1ccc(N)cc1)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A23 mock treatment 89160.0 -1350.0 -0.01 100120.0 -21400.0 -0.18 -0.1335 -0.7514 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 A24 mock treatment 42600.0 -47900.0 -0.41 111680.0 -9860.0 -0.08 -0.3462 -0.8321 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B01 mock treatment 125360.0 34800.0 0.3 118320.0 -3220.0 -0.03 0.1909 0.641 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B02 mock treatment 170280.0 79800.0 0.68 108680.0 -12900.0 -0.11 0.405 0.5891 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B03 compound treatment 183040.0 92500.0 0.79 124640.0 3100.0 0.03 0.5752 0.7297 683 SPBio_001941 Cc1ncc([N+](=O)[O-])n1CCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B04 compound treatment 204400.0 114000.0 0.97 97560.0 -24000.0 -0.2 0.5454 0.551 735 SPBio_001942 NNC(=O)c1ccncc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B05 compound treatment 227200.0 137000.0 1.16 93560.0 -28000.0 -0.23 0.6592 0.5556 1449 SPBio_001943 CN1[C@@H](CCC1=O)c2cccnc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B06 compound treatment 222960.0 132000.0 1.13 103000.0 -18500.0 -0.15 0.6889 0.6053 1008060 SPBio_001944 C1CCc2nnnn2CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B07 compound treatment 226040.0 136000.0 1.15 69240.0 -52300.0 -0.43 0.51 0.4138 1402 SPBio_001945 CC[N+](C)(C)c1cccc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B08 compound treatment 240920.0 150000.0 1.28 64600.0 -56900.0 -0.47 0.5724 0.4195 1480 SPBio_001946 Clc1ccc2oc(=O)[nH]c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B09 compound treatment 242440.0 152000.0 1.29 65040.0 -56500.0 -0.47 0.5842 0.4247 1029858 SPBio_001947 NC(=N)NC(=N)N1CCOCC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B10 compound treatment 246120.0 156000.0 1.32 77640.0 -43900.0 -0.36 0.68 0.495 1054660 SPBio_001948 Cc1ncc([N+](=O)[O-])n1CC(O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B11 compound treatment 250520.0 160000.0 1.36 155800.0 34300.0 0.28 1.1637 0.8363 678 SPBio_001949 NCC(CC(=O)O)c1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B12 compound treatment 243480.0 153000.0 1.3 188720.0 67200.0 0.56 1.3139 0.9279 869 SPBio_001950 CCC1(C)CC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B13 compound treatment 246480.0 156000.0 1.33 204800.0 83300.0 0.69 1.426 0.9533 839 SPBio_001951 Nc1nc2n(COCCO)cnc2c(=O)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B14 compound treatment 255720.0 165000.0 1.41 131040.0 9500.0 0.08 1.0502 0.7454 997 SPBio_001952 NCc1ccc(cc1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B15 compound treatment 235760.0 145000.0 1.24 75320.0 -46200.0 -0.38 0.6041 0.4667 35 SPBio_001953 CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B16 compound treatment 201600.0 111000.0 0.95 46360.0 -75200.0 -0.62 0.229 0.2023 399 SPBio_001954 Nc1nc2ccc(OC(F)(F)F)cc2s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B17 compound treatment 221600.0 131000.0 1.12 47560.0 -74000.0 -0.61 0.3564 0.28 1090166 SPBio_001955 CN(C)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B18 compound treatment 210600.0 120000.0 1.02 47480.0 -74100.0 -0.61 0.2897 0.2431 3173466 SPBio_001956 [O-][N+](=O)c1ccc(/C=N/N2CC(=O)NC2=O)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B19 compound treatment 54840.0 -35700.0 -0.3 25400.0 -96100.0 -0.8 -0.7772 -0.9128 3188940 SPBio_001957 C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CCC4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2[C@H]1C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B20 compound treatment 257040.0 167000.0 1.42 111080.0 -10500.0 -0.09 0.9414 0.6627 776 SPBio_001958 NNc1nncc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B21 compound treatment 197760.0 107000.0 0.91 74720.0 -46800.0 -0.39 0.3718 0.3748 1428 SPBio_001959 CC(C)NCC(O)COc1cccc2[nH]ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B22 compound treatment 183840.0 93300.0 0.79 114400.0 -7140.0 -0.06 0.5201 0.6527 3273 SPBio_001960 NNCCc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B23 mock treatment 182360.0 91800.0 0.78 107360.0 -14200.0 -0.12 0.47 0.5944 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 B24 mock treatment 73400.0 -17100.0 -0.15 110240.0 -11300.0 -0.09 -0.1691 -0.977 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C01 mock treatment 130160.0 39600.0 0.34 88080.0 -33500.0 -0.28 0.0429 0.0984 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C02 mock treatment 159040.0 68500.0 0.58 128720.0 7180.0 0.06 0.4545 0.775 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C03 compound treatment 35880.0 -54600.0 -0.47 47880.0 -73700.0 -0.61 -0.7598 -0.9911 2069342 SPBio_001961 COC1=CC(=O)C(=CC1=O)C(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C04 compound treatment 178240.0 87700.0 0.75 104600.0 -16900.0 -0.14 0.429 0.5646 2898 SPBio_001962 Cc1cc2CCCS(=O)(=O)c2cc1S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C05 compound treatment 209840.0 119000.0 1.02 150120.0 28600.0 0.24 0.8856 0.849 2060428 SPBio_001963 CCOC(=O)C(=O)C1(Oc2cc(OC)cc(OC)c2C(=O)C1c3ccccc3)C(=O)OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C06 compound treatment 244200.0 154000.0 1.31 122560.0 1020.0 0.01 0.9312 0.7116 3188932 SPBio_001964 CCCCNc1ccc(cc1)C(=O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C07 compound treatment 243400.0 153000.0 1.3 107960.0 -13600.0 -0.11 0.841 0.6437 966 SPBio_001965 OC[C@@H]1OC(=O)[C@@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C08 compound treatment 238120.0 148000.0 1.26 74400.0 -47100.0 -0.39 0.6129 0.4658 1131 SPBio_001966 NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C09 compound treatment 131240.0 40700.0 0.35 57440.0 -64100.0 -0.53 -0.1298 -0.2048 1000247 SPBio_001967 CC[C@@]1(O)C[C@H](O[C@H]2C[C@@H]([C@H](O[C@H]3C[C@H](O)[C@H](O[C@H]4CCC(=O)[C@H](C)O4)[C@H](C)O3)[C@H](C)O2)N(C)C)c5c(O)c6C(=O)c7c(O)cccc7C(=O)c6cc5[C@H]1C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C10 compound treatment 240440.0 150000.0 1.28 82400.0 -39100.0 -0.32 0.6737 0.5115 878 SPBio_001968 CC(=O)NS(=O)(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C11 compound treatment 224560.0 134000.0 1.14 130360.0 8820.0 0.07 0.8586 0.7508 1319 SPBio_001969 NCCCCN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C12 compound treatment 241960.0 151000.0 1.29 175680.0 54100.0 0.45 1.2285 0.9 1507 SPBio_001970 CC(N)CCCC(C)(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C13 compound treatment 237360.0 147000.0 1.25 195160.0 73600.0 0.61 1.3147 0.9453 3173726 SPBio_001971 NNC(=O)c1ccncc1.Nc1ccc(C(=O)O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C14 compound treatment 229160.0 139000.0 1.18 130560.0 9020.0 0.07 0.8875 0.7503 1175 SPBio_001972 Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C15 compound treatment 215600.0 125000.0 1.07 77240.0 -44300.0 -0.37 0.4939 0.4385 914 SPBio_001973 OC[C@H]1O[C@@H](OC2c3cccc(O)c3C(=O)c4c(O)cc(CO)cc24)[C@H](O)[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C16 compound treatment 164880.0 74400.0 0.63 47280.0 -74300.0 -0.61 0.0133 0.0151 1079 SPBio_001974 N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C17 compound treatment 226440.0 136000.0 1.16 63680.0 -57900.0 -0.48 0.4799 0.3832 768 SPBio_001975 C[N+](C)(C)CCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C18 compound treatment 182120.0 91600.0 0.78 65840.0 -55700.0 -0.46 0.2257 0.2491 3068957 SPBio_001976 OC[C@H]1O[C@H](CC1O)n2cc(I)c(=O)[nH]c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C19 compound treatment 236080.0 146000.0 1.24 115360.0 -6180.0 -0.05 0.8402 0.6773 3055573 SPBio_001977 OC[C@H]1OC([C@H](O)[C@@H]1O)n2cnc3c(=O)[nH]cnc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C20 compound treatment 218440.0 128000.0 1.09 98960.0 -22600.0 -0.19 0.6381 0.5774 3068958 SPBio_001978 CC(C)(CS)C(=O)N1CCC[C@@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C21 compound treatment 184760.0 94200.0 0.8 100840.0 -20700.0 -0.17 0.4463 0.5439 1193 SPBio_001979 CCOc1ccc(NC(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C22 compound treatment 138680.0 48200.0 0.41 81000.0 -40500.0 -0.34 0.0528 0.0997 82 SPBio_001980 Nc1cc(nc(N)[n+]1[O-])N2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C23 mock treatment 134560.0 44000.0 0.38 114680.0 -6860.0 -0.06 0.225 0.5933 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 C24 mock treatment 55120.0 -35400.0 -0.3 98240.0 -23300.0 -0.19 -0.3494 -0.9767 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D01 mock treatment 104480.0 14000.0 0.12 64880.0 -56700.0 -0.47 -0.2474 -0.5115 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D02 mock treatment 116400.0 25900.0 0.22 65480.0 -56100.0 -0.46 -0.1721 -0.3351 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D03 compound treatment 131040.0 40500.0 0.35 103000.0 -18500.0 -0.15 0.1355 0.3589 715 SPBio_001981 COc1c2ccoc2c(OC)c3oc(C)cc(=O)c13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D04 compound treatment 196440.0 106000.0 0.9 126120.0 4580.0 0.04 0.6645 0.7361 1262 SPBio_001982 NC[C@H]1CC[C@@H](CC1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D05 compound treatment 187560.0 97000.0 0.83 110400.0 -11100.0 -0.09 0.5191 0.6243 1002029 SPBio_001983 CN(C)C/C=C(/c1ccc(Br)cc1)\c2cccnc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D06 compound treatment 244360.0 154000.0 1.31 181320.0 59800.0 0.49 1.2759 0.9113 718 SPBio_001984 Cn1c(=O)n(C)c2ncn(CCO)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D07 compound treatment 20840.0 -69700.0 -0.59 11200.0 -110000.0 -0.91 -1.0649 -0.9782 1451360 SPBio_001985 OC(C1CCNCC1)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D08 compound treatment 210360.0 120000.0 1.02 111440.0 -10100.0 -0.08 0.6624 0.647 3069074 SPBio_001986 N[C@@H]1C[C@H]1c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D09 compound treatment 122680.0 32200.0 0.27 105760.0 -15800.0 -0.13 0.1013 0.334 1921128 SPBio_001987 Cn1cnc([N+](=O)[O-])c1Sc2ncnc3nc[nH]c23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D10 compound treatment 84760.0 -5750.0 -0.05 59960.0 -61600.0 -0.51 -0.3949 -0.7715 3256 SPBio_001988 CCN(CCCc1ccccc1)CCCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D11 compound treatment 21240.0 -69300.0 -0.59 13880.0 -108000.0 -0.89 -1.0469 -0.98 3069004 SPBio_001989 C[C@@]12CC[C@H]3[C@@H](CCC4=CCCC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D12 compound treatment 209400.0 119000.0 1.01 198240.0 76700.0 0.63 1.1644 0.9747 3069075 SPBio_001990 OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D13 compound treatment 219560.0 129000.0 1.1 212120.0 90600.0 0.75 1.3068 0.9826 3060090 SPBio_001991 NC(=N)N/N=C/c1c(Cl)cccc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D14 compound treatment 244760.0 154000.0 1.31 155880.0 34300.0 0.28 1.1295 0.8406 780 SPBio_001992 CC(C)NNC(=O)c1ccncc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D15 compound treatment 22160.0 -68400.0 -0.58 12400.0 -109000.0 -0.9 -1.05 -0.9774 2038 SPBio_001993 CCN(CC)C(=S)SSC(=S)N(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D16 compound treatment 231600.0 141000.0 1.2 103400.0 -18100.0 -0.15 0.7433 0.614 1256 SPBio_001994 Cc1cc(NS(=O)(=O)c2ccc(N)cc2)no1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D17 compound treatment 246280.0 156000.0 1.33 102280.0 -19300.0 -0.16 0.8251 0.6177 2060486 SPBio_001995 CC(=O)Oc1ccccc1C(=O)Oc2ccccc2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D18 compound treatment 242800.0 152000.0 1.3 91960.0 -29600.0 -0.24 0.7438 0.5637 741 SPBio_001996 Cc1ccccc1OCC(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D19 compound treatment 195520.0 105000.0 0.89 98600.0 -22900.0 -0.19 0.498 0.5448 1434 SPBio_001997 CN1CCN2C(C1)c3ccccc3Cc4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D20 compound treatment 223280.0 133000.0 1.13 119000.0 -2540.0 -0.02 0.7844 0.6938 1018627 SPBio_001998 NC(=N)NC(=N)NCCc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D21 compound treatment 131600.0 41100.0 0.35 110560.0 -11000.0 -0.09 0.1831 0.5066 440 SPBio_001999 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3cccs3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D22 compound treatment 147720.0 57200.0 0.49 96560.0 -25000.0 -0.21 0.1983 0.3747 1086 SPBio_002000 CC(C)C(=O)Nc1ccc([N+](=O)[O-])c(c1)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D23 mock treatment 136840.0 46300.0 0.39 96000.0 -25500.0 -0.21 0.1295 0.2894 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 D24 mock treatment 47480.0 -43000.0 -0.37 70640.0 -50900.0 -0.42 -0.5568 -0.9976 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E01 mock treatment 138480.0 48000.0 0.41 36920.0 -84600.0 -0.7 -0.2062 -0.2545 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E02 mock treatment 130280.0 39800.0 0.34 71360.0 -50200.0 -0.42 -0.0541 -0.1011 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E03 compound treatment 128040.0 37500.0 0.32 84440.0 -37100.0 -0.31 0.0089 0.0201 939 SPBio_002001 Cc1cccc(Nc2ccccc2C(=O)O)c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E04 compound treatment 204640.0 114000.0 0.97 157520.0 36000.0 0.3 0.8976 0.8832 944 SPBio_002002 Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E05 compound treatment 205320.0 115000.0 0.98 185000.0 63500.0 0.52 1.0624 0.9575 1668673 SPBio_002003 Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E06 compound treatment 229920.0 139000.0 1.19 179360.0 57800.0 0.48 1.1775 0.9201 3060 SPBio_002004 CC(C)(CO)[C@@H](O)C(=O)NCCCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E07 compound treatment 241760.0 151000.0 1.29 147200.0 25700.0 0.21 1.0607 0.8127 944 SPBio_002005 Nc1ccc(cc1)S(=O)(=O)Nc2ccnn2c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E08 compound treatment 244720.0 154000.0 1.31 152240.0 30700.0 0.25 1.108 0.8285 1159 SPBio_002006 Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E09 compound treatment 252440.0 162000.0 1.38 169200.0 47700.0 0.39 1.2537 0.8743 2060488 SPBio_002007 CC(=CCC[C@@](C)(O)C=C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E10 compound treatment 123880.0 33400.0 0.28 73920.0 -47600.0 -0.39 -0.0777 -0.16 3188934 SPBio_002008 C[C@@]12CC[C@H]3[C@@H](CCC4=C3CCC(=O)C4)[C@@H]2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E11 compound treatment 253040.0 163000.0 1.38 197200.0 75700.0 0.63 1.4211 0.9357 3198543 SPBio_002009 [Na+].Oc1ccccc1C(=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E12 compound treatment 271720.0 181000.0 1.54 316200.0 195000.0 1.61 2.2296 0.9998 1433 SPBio_002010 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CO)NC(=O)C(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E13 compound treatment 252480.0 162000.0 1.38 238240.0 117000.0 0.97 1.6578 0.9848 1603 SPBio_002011 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E14 compound treatment 242360.0 152000.0 1.29 184520.0 63000.0 0.52 1.2826 0.9201 3068961 SPBio_002012 CN/C(=N/C#N)/NCCSCC1N=CN=C1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E15 compound treatment 246960.0 156000.0 1.33 161040.0 39500.0 0.33 1.1729 0.8552 870 SPBio_002013 OC(=O)/C(=C/c1ccc(O)cc1)/C#N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E16 compound treatment 232800.0 142000.0 1.21 158840.0 37300.0 0.31 1.0748 0.8597 1432 SPBio_002014 CN(C)CCOC(C)(c1ccccc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E17 compound treatment 235240.0 145000.0 1.23 116600.0 -4940.0 -0.04 0.8424 0.6833 3055218 SPBio_002015 OCC(O)[C@H]1OC(=O)C(=C1O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E18 compound treatment 236800.0 146000.0 1.25 156400.0 34900.0 0.29 1.0846 0.8484 1000260 SPBio_002016 CC[C@H](CO)NCCN[C@H](CC)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E19 compound treatment 232200.0 142000.0 1.21 206800.0 85300.0 0.71 1.3518 0.9673 3198544 SPBio_002017 CC([C@H]1CCC2C3CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@]12C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E20 compound treatment 232760.0 142000.0 1.21 183600.0 62100.0 0.51 1.2194 0.927 1108 SPBio_002018 Cc1cc(=O)n(c2ccccc2)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E21 compound treatment 214320.0 124000.0 1.05 148800.0 27300.0 0.23 0.9048 0.8394 3471107 SPBio_002019 NC(=O)c1cc[n+](CC2=C(N3C(SC2)C(NC(=O)C(c4ccccc4)S(=O)(=O)O)C3=O)C(=O)O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E22 compound treatment 170200.0 79700.0 0.68 120040.0 -1500.0 -0.01 0.471 0.694 1079457 SPBio_002020 Cc1c(O)c(=O)n(c2ccccc2)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E23 mock treatment 128440.0 37900.0 0.32 130720.0 9180.0 0.08 0.282 0.8501 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 E24 mock treatment 55840.0 -34700.0 -0.3 66160.0 -55400.0 -0.46 -0.5327 -0.9774 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F01 mock treatment 134600.0 44100.0 0.38 61080.0 -60500.0 -0.5 -0.0883 -0.1411 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F02 mock treatment 132760.0 42200.0 0.36 85840.0 -35700.0 -0.3 0.0455 0.0977 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F03 compound treatment 17840.0 -72700.0 -0.62 17720.0 -104000.0 -0.86 -1.0449 -0.987 899 SPBio_002021 CN1CCc2cccc-3c2[C@H]1Cc4ccc(O)c(O)c43 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F04 compound treatment 209480.0 119000.0 1.01 134120.0 12600.0 0.1 0.7898 0.7757 1081 SPBio_002022 Cc1c(N)c(=O)n(c2ccccc2)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F05 compound treatment 199000.0 108000.0 0.92 123080.0 1540.0 0.01 0.6621 0.7168 885 SPBio_002023 Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F06 compound treatment 211600.0 121000.0 1.03 172160.0 50600.0 0.42 1.0251 0.9212 1274 SPBio_002024 C1CN2C[C@@H](N=C2S1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F07 compound treatment 162320.0 71800.0 0.61 108840.0 -12700.0 -0.11 0.358 0.5771 3326 SPBio_002025 CN1CCC(=C2c3ccccc3C=Cc4ccccc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F08 compound treatment 231400.0 141000.0 1.2 183600.0 62100.0 0.51 1.2112 0.9283 719 SPBio_002026 CN(CC#C)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F09 compound treatment 232960.0 142000.0 1.21 187160.0 65600.0 0.54 1.2414 0.9343 3177110 SPBio_002027 NC(=Nc1nc(CSCC/C(=N/S(=O)(=O)N)/N)cs1)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F10 compound treatment 236080.0 146000.0 1.24 178560.0 57000.0 0.47 1.2099 0.9124 1062 SPBio_002028 COc1ccccc1OCC(O)COC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F11 compound treatment 160160.0 69600.0 0.59 107200.0 -14300.0 -0.12 0.3354 0.5546 3189048 SPBio_002029 C[C@@]12CC[C@H]3[C@@H](CCC4=Cc5oncc5C[C@]34C)[C@@H]2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F12 compound treatment 237960.0 147000.0 1.26 244960.0 123000.0 1.02 1.6097 0.9947 3189063 SPBio_002030 C[C@H]1[C@H](NC(=O)/C(=N\OC(C)(C)C(=O)O)/c2csc(N)n2)C(=O)N1S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F13 compound treatment 226640.0 136000.0 1.16 253520.0 132000.0 1.09 1.5916 0.9996 3169 SPBio_002031 CCN(CC)C(=O)N[C@@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F14 compound treatment 236920.0 146000.0 1.25 178360.0 56800.0 0.47 1.2138 0.9111 1337 SPBio_002032 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F15 compound treatment 218640.0 128000.0 1.09 191760.0 70200.0 0.58 1.1821 0.9565 3189049 SPBio_002033 C[N+]1([O-])[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F16 compound treatment 218520.0 128000.0 1.09 175840.0 54300.0 0.45 1.0883 0.9232 724 SPBio_002034 CCn1cc(C(=O)O)c(=O)c2ccc(C)nc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F17 compound treatment 225800.0 135000.0 1.15 152840.0 31300.0 0.26 0.9976 0.845 1386 SPBio_002035 CN1CC(c2ccccc2)c3cccc(N)c3C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F18 compound treatment 244440.0 154000.0 1.31 195720.0 74200.0 0.61 1.3606 0.9402 3045683 SPBio_002036 C[N+]1(CCCCC[N+]2(C)CCCC2)CCCC1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F19 compound treatment 220400.0 130000.0 1.11 203760.0 82200.0 0.68 1.2629 0.9727 907387 SPBio_002037 C[C@@]1(N[C@@H]2Cc3ccccc31)c4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F20 compound treatment 214720.0 124000.0 1.06 198320.0 76800.0 0.64 1.1969 0.9702 1428839 SPBio_002038 C(Nc1ncnc2[nH]cnc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F21 compound treatment 193720.0 103000.0 0.88 198680.0 77100.0 0.64 1.0726 0.9877 3069006 SPBio_002039 CC(=O)CC(c1ccc(cc1)[N+](=O)[O-])c2c(O)c3ccccc3oc2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F22 compound treatment 191640.0 101000.0 0.86 125240.0 3700.0 0.03 0.6305 0.7318 198 SPBio_002040 CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F23 mock treatment 148200.0 57700.0 0.49 120280.0 -1260.0 -0.01 0.3399 0.6919 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 F24 mock treatment 43640.0 -46900.0 -0.4 63400.0 -58100.0 -0.48 -0.6223 -0.9957 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G01 mock treatment 104360.0 13800.0 0.12 95040.0 -26500.0 -0.22 -0.0717 -0.2879 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G02 mock treatment 121280.0 30800.0 0.26 77040.0 -44500.0 -0.37 -0.0751 -0.1662 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G03 compound treatment 123240.0 32700.0 0.28 94760.0 -26800.0 -0.22 0.0404 0.1134 3058484 SPBio_002041 CC(CCC(=O)O)[C@H]1CCC2C3C[C@H](O)[C@@H]4C[C@H](O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G04 compound treatment 199160.0 109000.0 0.93 138120.0 16600.0 0.14 0.7511 0.8031 3188935 SPBio_002042 OC[C@@H](NC(=O)C(Cl)Cl)[C@@H](O)c1ccc(cc1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G05 compound treatment 17360.0 -73200.0 -0.62 14360.0 -107000.0 -0.89 -1.0674 -0.9851 2069269 SPBio_002043 COC(=O)CCC(C)C1CCC2C3CCC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G06 compound treatment 242840.0 152000.0 1.3 185000.0 63500.0 0.52 1.2883 0.9207 2702 SPBio_002044 COc1cc(C)nn1c2nc(C)cc(OC)n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G07 compound treatment 214920.0 124000.0 1.06 199160.0 77600.0 0.64 1.203 0.9712 3059164 SPBio_002045 CC(C)CCCC(C)C1CCC2C3CC[C@H]4CC(=O)CC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G08 compound treatment 238120.0 148000.0 1.26 202520.0 81000.0 0.67 1.3624 0.9566 697 SPBio_002046 Cn1c(=O)n(C)c2ncn(CC(O)CO)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G09 compound treatment 25280.0 -65200.0 -0.56 20280.0 -101000.0 -0.84 -0.9851 -0.9801 2060111 SPBio_002047 COc1cc(O)c(cc1O)C(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G10 compound treatment 210960.0 120000.0 1.03 201800.0 80300.0 0.66 1.1946 0.9779 1061 SPBio_002048 Nc1nc(N)c2nc(c(N)nc2n1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G11 compound treatment 249240.0 159000.0 1.35 230760.0 109000.0 0.9 1.5945 0.9808 2069324 SPBio_002049 COc1cc(/C=C/C(=O)O)cc(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G12 compound treatment 230960.0 140000.0 1.2 249760.0 128000.0 1.06 1.5956 0.9982 1186 SPBio_002050 Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G13 compound treatment 232960.0 142000.0 1.21 285320.0 164000.0 1.35 1.8156 0.9985 1029168 SPBio_002051 CC(=O)c1ccc[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G14 compound treatment 229360.0 139000.0 1.18 254440.0 133000.0 1.1 1.6133 0.9993 3188936 SPBio_002052 COC1CC(O[C@@H]2[C@H](C)[C@H](OC3OC(C)CC(C3OC(=O)C)N(C)C)[C@H](C)CC4(CO4)C(=O)[C@@H](C)C(OC(=O)C)[C@H](C)[C@H](C)OC(=O)[C@@H]2C)OC(C)C1OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G15 compound treatment 35040.0 -55500.0 -0.47 92440.0 -29100.0 -0.24 -0.5042 -0.9511 2060336 SPBio_002053 CCOc1cccc(c1)C(=O)c2ccc(O)c(O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G16 compound treatment 181840.0 91300.0 0.78 200640.0 79100.0 0.65 1.0125 0.9963 1259 SPBio_002054 CCc1nc(N)nc(N)c1c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G17 compound treatment 219200.0 129000.0 1.1 202280.0 80700.0 0.67 1.247 0.9718 2060244 SPBio_002055 COC1=CC(=O)OC(CCc2ccc(OC)c(OC)c2)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G18 compound treatment 230080.0 140000.0 1.19 183000.0 61500.0 0.51 1.1998 0.9282 1270 SPBio_002056 C[N+](C)(C)CCCCCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G19 compound treatment 227920.0 137000.0 1.17 220400.0 98900.0 0.82 1.4055 0.9847 2060081 SPBio_002057 CC(=CCc1c(O)cc(C)oc1=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G20 compound treatment 188200.0 97700.0 0.83 192000.0 70500.0 0.58 1.0003 0.9849 1518 SPBio_002058 OC(=O)c1cc(ccc1O)c2ccc(F)cc2F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G21 compound treatment 189440.0 98900.0 0.84 174000.0 52500.0 0.43 0.9024 0.9524 1091 SPBio_002059 CCc1cn(C2OCC(O)C2CO)c(=O)nc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G22 compound treatment 29720.0 -60800.0 -0.52 34360.0 -87200.0 -0.72 -0.876 -0.9868 1313 SPBio_002060 Oc1ccc(Cl)cc1C(=O)Nc2ccc(cc2Cl)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G23 mock treatment 131520.0 41000.0 0.35 128360.0 6820.0 0.06 0.2868 0.8108 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 G24 mock treatment 36440.0 -54100.0 -0.46 80440.0 -41100.0 -0.34 -0.566 -0.9889 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H01 mock treatment 68560.0 -22000.0 -0.19 118040.0 -3500.0 -0.03 -0.1527 -0.8071 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H02 mock treatment 105600.0 15100.0 0.13 101640.0 -19900.0 -0.16 -0.0256 -0.1226 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H03 compound treatment 141480.0 51000.0 0.43 147640.0 26100.0 0.22 0.4595 0.948 929 SPBio_002061 Oc1ccc2C[C@H]3N(CC=C)CC[C@]4([C@H]5Oc1c24)[C@@]3(O)CCC5=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H04 compound treatment 189720.0 99200.0 0.84 173520.0 52000.0 0.43 0.9013 0.9509 1535 SPBio_002062 COc1ccc(OC)c(c1)C(O)CNC(=O)CN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H05 compound treatment 218560.0 128000.0 1.09 172000.0 50500.0 0.42 1.0661 0.9132 918 SPBio_002063 CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H06 compound treatment 247120.0 157000.0 1.33 207800.0 86300.0 0.71 1.4474 0.9571 370 SPBio_002064 O=C1N(C2CCC(=O)NC2=O)C(=O)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H07 compound treatment 237120.0 147000.0 1.25 222080.0 101000.0 0.83 1.4708 0.9805 757 SPBio_002065 OC(=O)c1cn(C2CC2)c3cc(N4CCNCC4)c(F)cc3c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H08 compound treatment 207120.0 117000.0 0.99 216440.0 94900.0 0.79 1.2572 0.9932 1266 SPBio_002066 CCn1cc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H09 compound treatment 218160.0 128000.0 1.09 211000.0 89500.0 0.74 1.2918 0.9825 1092 SPBio_002067 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H10 compound treatment 221320.0 131000.0 1.11 206360.0 84800.0 0.7 1.2837 0.9752 1298 SPBio_002068 CS(=O)(=O)Nc1ccc(cc1Oc2ccccc2)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H11 compound treatment 123640.0 33100.0 0.28 124080.0 2540.0 0.02 0.2143 0.7576 1261 SPBio_002069 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H12 compound treatment 223680.0 133000.0 1.13 287880.0 166000.0 1.38 1.7748 0.9954 1482 SPBio_002070 CN1CCc2cc3OCOc3cc2C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H13 compound treatment 245680.0 155000.0 1.32 282040.0 160000.0 1.33 1.873 1.0 3189051 SPBio_002071 Oc1ccc2C[C@H]3N(CC4CC4)CC[C@]5([C@H]6Oc1c25)[C@@]3(O)CCC6=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H14 compound treatment 212320.0 122000.0 1.04 261800.0 140000.0 1.16 1.5538 0.9984 1331 SPBio_002072 CC(=O)CCCCn1c(=O)n(C)c2ncn(C)c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H15 compound treatment 191920.0 101000.0 0.86 233400.0 112000.0 0.93 1.2648 0.9994 1207 SPBio_002073 CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H16 compound treatment 214680.0 124000.0 1.06 219360.0 97800.0 0.81 1.3197 0.9913 3189174 SPBio_002074 C[C@H](N)[C@H](O)c1cccc(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H17 compound treatment 194240.0 104000.0 0.88 228400.0 107000.0 0.88 1.2496 1.0 1027 SPBio_002075 O[C@H]1CC[C@@]2(O)[C@H]3Cc4ccc(O)c5O[C@@H]1[C@]2(CCN3CC6CCC6)c54 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H18 compound treatment 236600.0 146000.0 1.24 233480.0 112000.0 0.93 1.5343 0.9894 1523 SPBio_002076 CC(C)(C)NCC(O)c1ccc(O)c(CO)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H19 compound treatment 217120.0 127000.0 1.08 218960.0 97400.0 0.81 1.3321 0.9897 2241 SPBio_002077 COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H20 compound treatment 284160.0 194000.0 1.65 212880.0 91300.0 0.76 1.7001 0.9374 1436 SPBio_002078 CCCNC(C)C(=O)Nc1ccccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H21 compound treatment 183920.0 93400.0 0.8 201000.0 79500.0 0.66 1.0272 0.9955 1002008 SPBio_002079 C[C@@]12C[C@H](O)[C@@]3(F)[C@@H](CCC4=CC(=O)C=C[C@@]43C)[C@@H]2C[C@@H](O)[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H22 compound treatment 21320.0 -69200.0 -0.59 30960.0 -90600.0 -0.75 -0.9465 -0.9929 383 SPBio_002080 CC[C@@]1(O)C(=O)OCc2c1cc3-c4nc5ccccc5cc4Cn3c2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H23 mock treatment 153320.0 62800.0 0.53 145680.0 24100.0 0.2 0.5193 0.9098 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 H24 mock treatment 39400.0 -51100.0 -0.44 81600.0 -39900.0 -0.33 -0.5414 -0.9908 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I01 mock treatment 55200.0 -35300.0 -0.3 127400.0 5860.0 0.05 -0.1783 -0.5856 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I02 mock treatment 112960.0 22400.0 0.19 110760.0 -10800.0 -0.09 0.0721 0.3417 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I03 compound treatment 128040.0 37500.0 0.32 159200.0 37700.0 0.31 0.4462 0.9999 3080395 SPBio_002081 CC(C)CCCC(C)C1CCC2C3CC[C@H]4CCCC[C@]4(C)C3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I04 compound treatment 175600.0 85100.0 0.72 140160.0 18600.0 0.15 0.6212 0.8387 779 SPBio_002082 CCN(CC)CCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I05 compound treatment 210880.0 120000.0 1.02 202120.0 80600.0 0.67 1.196 0.9783 3526 SPBio_002083 Oc1ccc2ccc(=O)oc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I06 compound treatment 173160.0 82600.0 0.7 184240.0 62700.0 0.52 0.8643 0.9887 2847 SPBio_002084 CC(C)c1cc(OC(=O)C)c(C)cc1OCCN(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I07 compound treatment 147520.0 57000.0 0.49 153240.0 31700.0 0.26 0.5286 0.9582 3198545 SPBio_002085 Oc1ccc(/C=C/C=O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I08 compound treatment 199760.0 109000.0 0.93 231560.0 110000.0 0.91 1.3013 0.9999 3068964 SPBio_002086 NCCc1cc[nH]n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I09 compound treatment 162480.0 72000.0 0.61 178160.0 56600.0 0.47 0.7645 0.9912 1008535 SPBio_002087 COc1cccc(C=O)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I10 compound treatment 213640.0 123000.0 1.05 231880.0 110000.0 0.91 1.3867 0.9976 1268 SPBio_002088 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3cc(C)on3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I11 compound treatment 227400.0 137000.0 1.17 252520.0 131000.0 1.08 1.5903 0.9993 762 SPBio_002089 COc1cccc(OC)c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I12 compound treatment 241280.0 151000.0 1.28 260240.0 139000.0 1.15 1.719 0.9984 1000165 SPBio_002090 COc1ccc2cc(ccc2c1)[C@@H](C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I13 compound treatment 250560.0 160000.0 1.36 254320.0 133000.0 1.1 1.7403 0.9943 3055245 SPBio_002091 CCC[C@@H]1CCCCN1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I14 compound treatment 190560.0 100000.0 0.85 238680.0 117000.0 0.97 1.2875 0.9979 1083 SPBio_002092 C(C1=NCCN1)c2cccc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I15 compound treatment 15240.0 -75300.0 -0.64 18360.0 -103000.0 -0.85 -1.0568 -0.99 1496 SPBio_002093 CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I16 compound treatment 146800.0 56300.0 0.48 171520.0 50000.0 0.41 0.6312 0.9973 1821 SPBio_002094 Clc1ccccc1CN2CCc3sccc3C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I17 compound treatment 151640.0 61100.0 0.52 225360.0 104000.0 0.86 0.9753 0.9712 1280 SPBio_002095 NCCNC(=O)c1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I18 compound treatment 85360.0 -5150.0 -0.04 197880.0 76300.0 0.63 0.4155 0.6564 819 SPBio_002096 CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I19 compound treatment 224560.0 134000.0 1.14 237720.0 116000.0 0.96 1.4866 0.9963 1440 SPBio_002097 COc1ccc2cc(CCC(=O)C)ccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I20 compound treatment 188400.0 97900.0 0.83 204760.0 83200.0 0.69 1.0761 0.9955 3188937 SPBio_002098 CCC(C)(CN(C)C)OC(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I21 compound treatment 166880.0 76400.0 0.65 193200.0 71700.0 0.59 0.8789 0.9989 1069 SPBio_002099 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I22 compound treatment 162680.0 72200.0 0.61 193200.0 71700.0 0.59 0.8537 0.9998 362 SPBio_002100 CCN(CC)CC(=O)Nc1c(C)cccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I23 mock treatment 182880.0 92400.0 0.79 133440.0 11900.0 0.1 0.6257 0.7894 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 I24 mock treatment 35120.0 -55400.0 -0.47 100640.0 -20900.0 -0.17 -0.4558 -0.9073 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J01 mock treatment 47640.0 -42900.0 -0.37 169240.0 47700.0 0.39 0.0209 0.0389 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J02 mock treatment 95240.0 4730.0 0.04 145200.0 23700.0 0.2 0.1668 0.8351 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J03 compound treatment 93600.0 3090.0 0.03 128480.0 6940.0 0.06 0.0592 0.9374 1000273 SPBio_002101 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J04 compound treatment 151880.0 61400.0 0.52 193200.0 71700.0 0.59 0.7886 0.998 1068 SPBio_002102 CN/C(=C\[N+](=O)[O-])/NCCSCc1ccc(CN(C)C)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J05 compound treatment 180160.0 89600.0 0.76 201920.0 80400.0 0.66 1.0099 0.9976 3069040 SPBio_002103 CNCC(O)c1ccc(O)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J06 compound treatment 127720.0 37200.0 0.32 126480.0 4940.0 0.04 0.2529 0.7917 3069077 SPBio_002104 OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J07 compound treatment 186160.0 95600.0 0.81 258520.0 137000.0 1.13 1.3771 0.9869 3189053 SPBio_002105 CC(C)CCC(=O)O.C[C@]12CCC[C@H]2[C@H]3[C@H](CC1=O)[C@@]4(C)CCC(=O)C[C@H]4CC3=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J08 compound treatment 121440.0 30900.0 0.26 175200.0 53700.0 0.44 0.5001 0.9689 41 SPBio_002106 OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J09 compound treatment 228000.0 137000.0 1.17 292000.0 170000.0 1.41 1.8249 0.9957 1610 SPBio_002107 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J10 compound treatment 213320.0 123000.0 1.05 273080.0 152000.0 1.25 1.6258 0.9959 752 SPBio_002108 CC1CCc2cc(F)cc3c(=O)c(cn1c23)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J11 compound treatment 36680.0 -53800.0 -0.46 50000.0 -71500.0 -0.59 -0.7426 -0.992 1465 SPBio_002109 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J12 compound treatment 136080.0 45600.0 0.39 192600.0 71100.0 0.59 0.69 0.9797 1258696 SPBio_002110 Cc1c(Cl)cccc1Nc2ccccc2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J13 compound treatment 192720.0 102000.0 0.87 253160.0 132000.0 1.09 1.3853 0.9938 1387 SPBio_002111 OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J14 compound treatment 105640.0 15100.0 0.13 134640.0 13100.0 0.11 0.1677 0.9963 1123 SPBio_002112 Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J15 compound treatment 12200.0 -78300.0 -0.67 17720.0 -104000.0 -0.86 -1.0788 -0.9922 3487389 SPBio_002113 Clc1ccc(C(Cn2ccnc2)OCc3c(Cl)cccc3Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J16 compound treatment 176080.0 85600.0 0.73 263080.0 142000.0 1.17 1.3431 0.9739 3189175 SPBio_002114 COC1=CC(=O)O[C@H](C1)/C=C/c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J17 compound treatment 141720.0 51200.0 0.44 232840.0 111000.0 0.92 0.9593 0.9417 3189054 SPBio_002115 CC(=O)S[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CC[C@]54CCC(=O)O5)[C@H]13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J18 compound treatment 203480.0 113000.0 0.96 258200.0 137000.0 1.13 1.4795 0.9968 1201 SPBio_002116 COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J19 compound treatment 208440.0 118000.0 1.0 238280.0 117000.0 0.97 1.3929 0.9998 786 SPBio_002117 CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J20 compound treatment 201680.0 111000.0 0.95 240040.0 118000.0 0.98 1.3625 0.9998 734 SPBio_002118 CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J21 compound treatment 156600.0 66100.0 0.56 218320.0 96800.0 0.8 0.964 0.9851 1000246 SPBio_002119 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J22 compound treatment 93880.0 3370.0 0.03 133000.0 11500.0 0.09 0.0873 0.8816 1281686 SPBio_002120 COC(=O)Nc1nc2cc(Sc3ccccc3)ccc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J23 mock treatment 136520.0 46000.0 0.39 181240.0 59700.0 0.49 0.6262 0.9934 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 J24 mock treatment 51040.0 -39500.0 -0.34 132440.0 10900.0 0.09 -0.1739 -0.4998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K01 mock treatment 39560.0 -51000.0 -0.43 170120.0 48600.0 0.4 -0.0226 -0.0382 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K02 mock treatment 84200.0 -6310.0 -0.05 147680.0 26100.0 0.22 0.1149 0.5157 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K03 compound treatment 79760.0 -10800.0 -0.09 117080.0 -4460.0 -0.04 -0.0908 -0.9203 2060334 SPBio_002121 C[C@H]1[C@@H](O)C[C@H]2[C@@H]1[C@H](O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)OC=C2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K04 compound treatment 135320.0 44800.0 0.38 198760.0 77200.0 0.64 0.7215 0.9696 1010605 SPBio_002122 COP(=O)(OC)C(O)C(Cl)(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K05 compound treatment 160920.0 70400.0 0.6 228360.0 107000.0 0.88 1.0487 0.9821 2060497 SPBio_002123 CC(C)(O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O)C#N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K06 compound treatment 185600.0 95100.0 0.81 250560.0 129000.0 1.07 1.3272 0.9907 1019 SPBio_002124 NC(=O)N1c2ccccc2C=Cc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K07 compound treatment 135160.0 44600.0 0.38 209240.0 87700.0 0.73 0.7818 0.9545 1765 SPBio_002125 CC1(C)NC(=O)N(C1=O)c2ccc([N+](=O)[O-])c(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K08 compound treatment 57560.0 -33000.0 -0.28 182640.0 61100.0 0.51 0.159 0.2751 1401 SPBio_002126 CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K09 compound treatment 152680.0 62200.0 0.53 217400.0 95900.0 0.79 0.935 0.9807 3057756 SPBio_002127 C1CCN2C[C@H]3C[C@@H](CN4CCCC[C@H]34)[C@@H]2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K10 compound treatment 168520.0 78000.0 0.66 298960.0 177000.0 1.47 1.5075 0.9357 939 SPBio_002128 Cc1cccc(Nc2ccccc2C(=O)O)c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K11 compound treatment 204480.0 114000.0 0.97 262960.0 141000.0 1.17 1.5134 0.9957 3198546 SPBio_002129 CC(=CCC/C(=C/COC(=O)\C=C\c1ccccc1)/C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K12 compound treatment 211520.0 121000.0 1.03 291400.0 170000.0 1.41 1.7221 0.9884 3186 SPBio_002130 CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K13 compound treatment 160080.0 69600.0 0.59 196560.0 75000.0 0.62 0.8577 0.9997 3198547 SPBio_002131 CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)c4ccccc4C(=O)O)c5nc6ccccc6n5C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K14 compound treatment 183120.0 92600.0 0.79 297080.0 176000.0 1.45 1.5844 0.9588 920 SPBio_002132 CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K15 compound treatment 18520.0 -72000.0 -0.61 26000.0 -95500.0 -0.79 -0.9923 -0.9921 2060467 SPBio_002133 COc1ccc2C(=O)/C(=C\c3ccc(OC)c(OC)c3)/COc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K16 compound treatment 63600.0 -26900.0 -0.23 120600.0 -944.0 -0.01 -0.1675 -0.7308 3127 SPBio_002134 CCCCOc1cc(ccc1N)C(=O)OCCN(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K17 compound treatment 145440.0 54900.0 0.47 227320.0 106000.0 0.88 0.9495 0.9569 1024489 SPBio_002135 Cc1cc(O)cc(=O)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K18 compound treatment 109520.0 19000.0 0.16 181800.0 60300.0 0.5 0.4669 0.8909 1318 SPBio_002136 CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K19 compound treatment 114880.0 24400.0 0.21 138000.0 16500.0 0.14 0.243 0.9791 3045136 SPBio_002137 CC[C@H](C)C(=O)O[C@H]1CCC=C2C=C[C@H](C)C(CCC3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K20 compound treatment 156480.0 66000.0 0.56 277280.0 156000.0 1.29 1.3082 0.9308 884 SPBio_002138 CN(C)CCC(c1ccccc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K21 compound treatment 157520.0 67000.0 0.57 243320.0 122000.0 1.01 1.1158 0.9637 794 SPBio_002139 Nc1cc(c[nH]c1=O)c2ccncc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K22 compound treatment 107800.0 17300.0 0.15 223720.0 102000.0 0.85 0.7018 0.8179 965 SPBio_002140 C(C1=NCCN1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K23 mock treatment 165040.0 74500.0 0.63 167360.0 45800.0 0.38 0.7167 0.9697 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 K24 mock treatment 36440.0 -54100.0 -0.46 194680.0 73100.0 0.61 0.1023 0.1345 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L01 mock treatment 32920.0 -57600.0 -0.49 142120.0 20600.0 0.17 -0.2264 -0.4361 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L02 mock treatment 77200.0 -13300.0 -0.11 158640.0 37100.0 0.31 0.1369 0.4183 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L03 compound treatment 111240.0 20700.0 0.18 163680.0 42100.0 0.35 0.3713 0.9503 72 SPBio_002141 Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L04 compound treatment 116480.0 26000.0 0.22 181160.0 59600.0 0.49 0.5051 0.9345 347 SPBio_002142 CN1C(=C(O)c2ccccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L05 compound treatment 109680.0 19200.0 0.16 196880.0 75300.0 0.62 0.5561 0.8632 4362 SPBio_002143 CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L06 compound treatment 170480.0 80000.0 0.68 225720.0 104000.0 0.86 1.0908 0.9932 3069079 SPBio_002144 CN1CCCN=C1/C=C/c2cccs2.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L07 compound treatment 75920.0 -14600.0 -0.12 150800.0 29300.0 0.24 0.0833 0.3061 3487390 SPBio_002145 OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L08 compound treatment 119760.0 29200.0 0.25 219040.0 97500.0 0.81 0.7464 0.8842 1144 SPBio_002146 O=C1NCC2(CCN(CCc3ccccc3)CC2)O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L09 compound treatment 149760.0 59200.0 0.5 258240.0 137000.0 1.13 1.1563 0.9338 355 SPBio_002147 COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L10 compound treatment 158560.0 68000.0 0.58 255960.0 134000.0 1.11 1.196 0.9538 796 SPBio_002148 Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L11 compound treatment 177960.0 87400.0 0.74 75560.0 -46000.0 -0.38 0.2575 0.308 464 SPBio_002149 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L12 compound treatment 238720.0 148000.0 1.26 375080.0 254000.0 2.1 2.3754 0.9704 1346 SPBio_002150 CCN(CC)CCNC(=O)COc1ccc(OC)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L13 compound treatment 17120.0 -73400.0 -0.62 28760.0 -92800.0 -0.77 -0.9846 -0.9948 709 SPBio_002151 COc1ccc(CCN2CCC(CC2)Nc3nc4ccccc4n3Cc5ccc(F)cc5)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L14 compound treatment 165200.0 74700.0 0.64 287760.0 166000.0 1.38 1.422 0.9386 1339 SPBio_002152 CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L15 compound treatment 117120.0 26600.0 0.23 261760.0 140000.0 1.16 0.9804 0.8295 3189055 SPBio_002153 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@H](C)Cl)C2O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L16 compound treatment 99600.0 9090.0 0.08 145280.0 23700.0 0.2 0.1936 0.9171 1350 SPBio_002154 COC(=O)Nc1nc2cc(ccc2[nH]1)C(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L17 compound treatment 70840.0 -19700.0 -0.17 259520.0 138000.0 1.14 0.6887 0.597 1590 SPBio_002155 CC(C)(C)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L18 compound treatment 149400.0 58900.0 0.5 258960.0 137000.0 1.14 1.1584 0.9323 699 SPBio_002156 OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L19 compound treatment 165320.0 74800.0 0.64 341200.0 220000.0 1.82 1.7353 0.9012 3060388 SPBio_002157 CO/N=C(\C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)C)/c3csc(N)n3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L20 compound treatment 148760.0 58200.0 0.5 233680.0 112000.0 0.93 1.0066 0.957 1209 SPBio_002158 CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L21 compound treatment 145040.0 54500.0 0.46 251000.0 129000.0 1.07 1.0856 0.93 1418 SPBio_002159 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L22 compound treatment 99720.0 9210.0 0.08 196960.0 75400.0 0.62 0.4966 0.7898 3069113 SPBio_002160 CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L23 mock treatment 91920.0 1410.0 0.01 204080.0 82500.0 0.68 0.4913 0.7194 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 L24 mock treatment 44760.0 -45800.0 -0.39 179200.0 57700.0 0.48 0.0618 0.1004 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M01 mock treatment 49440.0 -41100.0 -0.35 154400.0 32900.0 0.27 -0.0551 -0.1244 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M02 mock treatment 80280.0 -10200.0 -0.09 186000.0 64500.0 0.53 0.3154 0.5838 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M03 compound treatment 70480.0 -20000.0 -0.17 189680.0 68100.0 0.56 0.278 0.472 1110410 SPBio_002161 COc1ccc(C(=O)C)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M04 compound treatment 92640.0 2130.0 0.02 181640.0 60100.0 0.5 0.3644 0.7324 3188938 SPBio_002162 CN1CCCN=C1/C=C/c2sccc2C.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M05 compound treatment 97720.0 7210.0 0.06 211280.0 89700.0 0.74 0.5683 0.763 1582 SPBio_002163 O=C1CCO1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M06 compound treatment 94400.0 3890.0 0.03 206160.0 84600.0 0.7 0.5184 0.7397 3068999 SPBio_002164 CN1[C@H]2CC[C@@H]1CC(C2)OC(=O)C(O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M07 compound treatment 52360.0 -38200.0 -0.32 123800.0 2260.0 0.02 -0.2165 -0.6654 104 SPBio_002165 C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M08 compound treatment 10880.0 -79600.0 -0.68 30520.0 -91000.0 -0.75 -1.0119 -0.9986 110 SPBio_002166 COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M09 compound treatment 116120.0 25600.0 0.22 278840.0 157000.0 1.3 1.0743 0.8142 1000323 SPBio_002167 N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M10 compound treatment 79120.0 -11400.0 -0.1 215240.0 93700.0 0.78 0.4795 0.6138 436 SPBio_002168 CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M11 compound treatment 133800.0 43300.0 0.37 277200.0 156000.0 1.29 1.1712 0.8744 1328 SPBio_002169 OC(CCN1CCCCC1)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M12 compound treatment 194120.0 104000.0 0.88 282520.0 161000.0 1.33 1.5654 0.98 1002 SPBio_002170 CN(C)CCOC(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M13 compound treatment 153320.0 62800.0 0.53 217880.0 96300.0 0.8 0.9417 0.9812 1510 SPBio_002171 CN(C)CCN(Cc1cccs1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M14 compound treatment 133920.0 43400.0 0.37 278880.0 157000.0 1.3 1.1817 0.8734 728 SPBio_002172 Cc1cc(nnc1NCCN2CCOCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M15 compound treatment 19160.0 -71400.0 -0.61 125080.0 3540.0 0.03 -0.4089 -0.6723 1318 SPBio_002173 CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M16 compound treatment 7360.0 -83200.0 -0.71 20000.0 -102000.0 -0.84 -1.0946 -0.9964 814 SPBio_002174 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M17 compound treatment 91600.0 1090.0 0.01 266360.0 145000.0 1.2 0.8537 0.7126 3174608 SPBio_002175 COC1C(O)C(O)C(O)[C@@H](O)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M18 compound treatment 99040.0 8530.0 0.07 229360.0 108000.0 0.89 0.682 0.7622 3471598 SPBio_002176 CC(COc1ccccc1)NC(C)C(O)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M19 compound treatment 69320.0 -21200.0 -0.18 93840.0 -27700.0 -0.23 -0.2896 -0.993 1035250 SPBio_002177 CC(=O)c1c(O)cc(O)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M20 compound treatment 118960.0 28400.0 0.24 227240.0 106000.0 0.87 0.7896 0.8702 1223 SPBio_002178 CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M21 compound treatment 100920.0 10400.0 0.09 240120.0 119000.0 0.98 0.7563 0.7679 3080396 SPBio_002179 CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M22 compound treatment 106400.0 15900.0 0.14 217480.0 95900.0 0.79 0.6568 0.8159 971 SPBio_002180 CN(C(=S)Oc1ccc2ccccc2c1)c3cccc(C)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M23 mock treatment 78680.0 -11800.0 -0.1 168120.0 46600.0 0.39 0.2012 0.5052 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 M24 mock treatment 59960.0 -30600.0 -0.26 172160.0 50600.0 0.42 0.1121 0.2275 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N01 mock treatment 76440.0 -14100.0 -0.12 158760.0 37200.0 0.31 0.133 0.4025 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N02 mock treatment 87760.0 -2750.0 -0.02 207840.0 86300.0 0.71 0.4882 0.6835 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N03 compound treatment 66120.0 -24400.0 -0.21 173760.0 52200.0 0.43 0.1586 0.3309 1000056 SPBio_002181 COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N04 compound treatment 74960.0 -15600.0 -0.13 219400.0 97900.0 0.81 0.4788 0.5837 747 SPBio_002182 CCn1cc(C(=O)O)c(=O)c2cc(F)c(cc12)N3CCNCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N05 compound treatment 49280.0 -41200.0 -0.35 177760.0 56200.0 0.47 0.0806 0.1383 1301 SPBio_002183 OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N06 compound treatment 37960.0 -52600.0 -0.45 89120.0 -32400.0 -0.27 -0.5061 -0.9701 3189176 SPBio_002184 CCCCCC[C@@H]1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)C(NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N07 compound treatment 6360.0 -84200.0 -0.72 24800.0 -96700.0 -0.8 -1.0726 -0.9985 1360 SPBio_002185 Clc1ccc(NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)Nc2ccc(Cl)cc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N08 compound treatment 62920.0 -27600.0 -0.23 214840.0 93300.0 0.77 0.3796 0.4706 816 SPBio_002186 Cc1cc(cc(C)c1CC2=NCCN2)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N09 compound treatment 42000.0 -48500.0 -0.41 157000.0 35500.0 0.29 -0.0847 -0.1671 80 SPBio_002187 CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N10 compound treatment 95840.0 5330.0 0.05 229480.0 108000.0 0.89 0.6635 0.7421 1181 SPBio_002188 Cc1cc(c(O)c(C)c1CC2=NCCN2)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N11 compound treatment 119200.0 28700.0 0.24 266600.0 145000.0 1.2 1.0212 0.8339 901 SPBio_002189 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N12 compound treatment 174240.0 83700.0 0.71 260720.0 139000.0 1.15 1.3182 0.9734 1162 SPBio_002190 Cc1c(NC(=O)c2cccnc2)c(=O)n(c3ccccc3)n1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N13 compound treatment 11880.0 -78600.0 -0.67 23080.0 -98500.0 -0.81 -1.0494 -0.9953 368 SPBio_002191 CC/C(=C(\c1ccccc1)/c2ccc(OCCN(C)C)cc2)/c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N14 compound treatment 134920.0 44400.0 0.38 238440.0 117000.0 0.97 0.9512 0.916 3069117 SPBio_002192 COC1CC(=O)C[C@@H](C)[C@@]21Oc3c(C2=O)c(OC)cc(OC)c3Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N15 compound treatment 83160.0 -7350.0 -0.06 234040.0 112000.0 0.93 0.6138 0.6581 783 SPBio_002193 CO[C@@]12C[C@@H](COC(=O)c3cncc(Br)c3)CN(C)[C@@H]2Cc4cn(C)c5cccc1c45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N16 compound treatment 25680.0 -64800.0 -0.55 97360.0 -24200.0 -0.2 -0.5318 -0.9057 386963 SPBio_002194 Clc1ccc(Cn2c(CN3CCCC3)nc4ccccc24)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N17 compound treatment 56400.0 -34100.0 -0.29 288680.0 167000.0 1.38 0.7723 0.5466 2784 SPBio_002195 C[C@@]12CC[C@H]3[C@@H](C=CC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@]1(O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N18 compound treatment 48800.0 -41700.0 -0.36 245120.0 124000.0 1.02 0.4718 0.4359 1075 SPBio_002196 CCN(Cc1ccncc1)C(=O)C(CO)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N19 compound treatment 56120.0 -34400.0 -0.29 193320.0 71800.0 0.59 0.2128 0.3214 3189056 SPBio_002197 CN(C)S(=O)(=O)c1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N20 compound treatment 92040.0 1530.0 0.01 209120.0 87600.0 0.72 0.5215 0.7197 1016 SPBio_002198 CN1CCOC(c2ccccc2)c3ccccc3C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N21 compound treatment 71880.0 -18600.0 -0.16 191840.0 70300.0 0.58 0.299 0.4961 3189057 SPBio_002199 CN1C[C@@H](C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34)C(=O)N[C@]5(C)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C5=O.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N22 compound treatment 73680.0 -16800.0 -0.14 201240.0 79700.0 0.66 0.3649 0.5408 3046406 SPBio_002200 Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N23 mock treatment 93480.0 2970.0 0.03 178640.0 57100.0 0.47 0.3519 0.7439 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 N24 mock treatment 39920.0 -50600.0 -0.43 126720.0 5180.0 0.04 -0.2743 -0.6337 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O01 mock treatment 77440.0 -13100.0 -0.11 89160.0 -32400.0 -0.27 -0.2681 -0.9243 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O02 mock treatment 62840.0 -27700.0 -0.24 195280.0 73700.0 0.61 0.2647 0.4048 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O03 compound treatment 41440.0 -49100.0 -0.42 164320.0 42800.0 0.35 -0.0452 -0.0826 1572 SPBio_002201 CCCC(C)C1(CC)C(=O)NC(=NC1=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O04 compound treatment 53360.0 -37200.0 -0.32 249040.0 127000.0 1.05 0.5221 0.4742 1125 SPBio_002202 CCOC(=O)NNc1nncc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O05 compound treatment 53880.0 -36600.0 -0.31 233360.0 112000.0 0.93 0.4335 0.4441 2060373 SPBio_002203 COc1c(O)cc2c(cc(=O)oc2c1OC)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O06 compound treatment 45000.0 -45500.0 -0.39 173800.0 52300.0 0.43 0.0317 0.0546 1174 SPBio_002204 CN(C)CCCN1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O07 compound treatment 34080.0 -56400.0 -0.48 282320.0 161000.0 1.33 0.6007 0.4248 1019888 SPBio_002205 NCC(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O08 compound treatment 35720.0 -54800.0 -0.47 280720.0 159000.0 1.32 0.6013 0.4304 3188939 SPBio_002206 CC/1=C(CC(=O)O)c2cc(F)ccc2\C1=C\c3ccc(cc3)S(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O09 compound treatment 40680.0 -49800.0 -0.42 316320.0 195000.0 1.61 0.8394 0.5037 2069272 SPBio_002207 CC1C[C@H]2CC(=O)[C@H]3CCCN4CCC[C@H]2[C@]34C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O10 compound treatment 33720.0 -56800.0 -0.48 197880.0 76300.0 0.63 0.1046 0.1315 1365 SPBio_002208 CN(C)CCC=C1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O11 compound treatment 91440.0 928.0 0.01 424640.0 303000.0 2.51 1.7786 0.7093 2060313 SPBio_002209 C/C/1=C/CC(C)(C)\C=C\C\C(=C\CC1)\C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O12 compound treatment 185840.0 95300.0 0.81 286440.0 165000.0 1.36 1.5385 0.9692 872 SPBio_002210 CCN(CC)CCOC(=O)C(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O13 compound treatment 215280.0 125000.0 1.06 282800.0 161000.0 1.33 1.6945 0.9936 2060368 SPBio_002211 CNC(Cc1c[nH]c2ccccc12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O14 compound treatment 50400.0 -40100.0 -0.34 104120.0 -17400.0 -0.14 -0.3434 -0.9264 969 SPBio_002212 CCCCOc1cc(C(=O)NCCN(CC)CC)c2ccccc2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O15 compound treatment 65160.0 -25400.0 -0.22 223680.0 102000.0 0.84 0.4448 0.5101 1635952 SPBio_002213 Cn1nnnc1SCC2=C(N3C(SC2)C(NC(=O)C(O)c4ccccc4)C3=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O16 compound treatment 41840.0 -48700.0 -0.41 256520.0 135000.0 1.12 0.4965 0.4169 2080073 SPBio_002214 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O17 compound treatment 41080.0 -49400.0 -0.42 313680.0 192000.0 1.59 0.8263 0.5026 1573 SPBio_002215 CCCC(C)C1(CC)C(=O)NC(=NC1=O)S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O18 compound treatment 5480.0 -85000.0 -0.72 19840.0 -102000.0 -0.84 -1.1069 -0.9972 731 SPBio_002216 CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O19 compound treatment 68080.0 -22400.0 -0.19 258400.0 137000.0 1.13 0.6655 0.5796 89599 SPBio_002217 OC(=O)c1cc(O)c2c(Cl)cc(Cl)cc2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O20 compound treatment 67800.0 -22700.0 -0.19 243640.0 122000.0 1.01 0.5775 0.5615 1001312 SPBio_002218 C[N+]1(C)CCC(=C(c2ccccc2)c3ccccc3)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O21 compound treatment 74000.0 -16500.0 -0.14 256320.0 135000.0 1.11 0.689 0.6131 3198548 SPBio_002219 OC(=O)CCC/C=C\C[C@@H]1CO[C@@H](O[C@@H]1c2ccccc2O)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O22 compound treatment 93440.0 2930.0 0.02 196440.0 74900.0 0.62 0.4557 0.735 1053 SPBio_002220 COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O23 mock treatment 70520.0 -20000.0 -0.17 200520.0 79000.0 0.65 0.3416 0.506 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 O24 mock treatment 67840.0 -22700.0 -0.19 157760.0 36200.0 0.3 0.0754 0.2114 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P01 mock treatment 65160.0 -25400.0 -0.22 40600.0 -80900.0 -0.67 -0.6261 -0.8899 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P02 mock treatment 67720.0 -22800.0 -0.19 97840.0 -23700.0 -0.2 -0.2759 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P03 compound treatment 47960.0 -42600.0 -0.36 100080.0 -21500.0 -0.18 -0.3817 -0.9461 3069044 SPBio_002221 CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P04 compound treatment 54560.0 -36000.0 -0.31 136240.0 14700.0 0.12 -0.1305 -0.3962 805 SPBio_002222 CCc1cccc2c3CCOC(CC)(CC(=O)O)c3[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P05 compound treatment 37240.0 -53300.0 -0.45 198040.0 76500.0 0.63 0.1268 0.1628 3189058 SPBio_002223 COC1CC(O[C@H]2[C@H](C)[C@@H](OC3OC(C)CC(C3O)N(C)C)[C@@H](C)C[C@]4(CO4)C(=O)[C@H](C)[C@@H](O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C)OC(C)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P06 compound treatment 58200.0 -32300.0 -0.28 256800.0 135000.0 1.12 0.5967 0.5178 3069144 SPBio_002224 C[N+]1([O-])[C@H]2C[C@@H](C[C@@H]1[C@H]3O[C@H]32)OC(=O)[C@H](CO)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P07 compound treatment 31560.0 -59000.0 -0.5 332920.0 211000.0 1.75 0.8816 0.4846 3189059 SPBio_002225 CCC(=O)OC1C(C)OC(CC1(C)O)OC2C(C)OC(O[C@H]3[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](OC(=O)CC)[C@@H]3OC)C(O)C2N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P08 compound treatment 44200.0 -46300.0 -0.39 201360.0 79800.0 0.66 0.1881 0.2445 1000200 SPBio_002226 CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)[C@@H](CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P09 compound treatment 46640.0 -43900.0 -0.37 301040.0 179000.0 1.48 0.7859 0.5132 3069045 SPBio_002227 CO[C@H]1[C@@H](CC(=O)O[C@H](C)C/C=C/C=C/[C@H](O)[C@H](C)C[C@H](CC=O)[C@@H]1OC2OC(C)C(OC3CC(C)(O)C(OC(=O)CC(C)C)C(C)O3)C(C2O)N(C)C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P10 compound treatment 41320.0 -49200.0 -0.42 301760.0 180000.0 1.49 0.758 0.4895 3487401 SPBio_002228 NC(=O)OCC(O)COc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P11 compound treatment 78240.0 -12300.0 -0.1 155240.0 33700.0 0.28 0.1232 0.4139 3189060 SPBio_002229 CC(=O)O[C@@H]1C2=C(C)[C@@H](C[C@](O)([C@H](OC(=O)c3ccccc3)[C@H]4[C@]5(CO[C@H]5C[C@@H](O)[C@]4(C)C1=O)OC(=O)C)C2(C)C)OC(=O)[C@@H](O)[C@H](NC(=O)c6ccccc6)c7ccccc7 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P12 compound treatment 109480.0 19000.0 0.16 193680.0 72100.0 0.6 0.5362 0.8673 3189177 SPBio_002230 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N=C)c3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P13 compound treatment 6920.0 -83600.0 -0.71 14920.0 -107000.0 -0.88 -1.127 -0.9943 3189061 SPBio_002231 CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C/C=C(\C)/C(O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P14 compound treatment 52200.0 -38300.0 -0.33 240520.0 119000.0 0.98 0.4653 0.4488 2997 SPBio_002232 COc1cc(cc(OC)c1OC)C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P15 compound treatment 58240.0 -32300.0 -0.27 244360.0 123000.0 1.02 0.5241 0.498 1257 SPBio_002233 CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P16 compound treatment 41240.0 -49300.0 -0.42 234720.0 113000.0 0.94 0.3654 0.3562 1323 SPBio_002234 CC1COc2c(N3CCN(C)CC3)c(F)cc4c(=O)c(cn1c24)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P17 compound treatment 46880.0 -43600.0 -0.37 247560.0 126000.0 1.04 0.4745 0.4287 3069046 SPBio_002235 NCC1OC(COC[C@@H]2C(O)[C@H](OC3C(O)C(N)CC(N)C3OC4OC(CN)C(O)C(O)C4N)O[C@@H]2CO)C(N)C(O)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P18 compound treatment 30040.0 -60500.0 -0.51 222880.0 101000.0 0.84 0.2287 0.2325 999 SPBio_002236 CCn1cc(C(=O)O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P19 compound treatment 44880.0 -45600.0 -0.39 231040.0 109000.0 0.91 0.3658 0.3711 3069047 SPBio_002237 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P20 compound treatment 47560.0 -43000.0 -0.37 151880.0 30300.0 0.25 -0.0811 -0.1829 1443 SPBio_002238 CN(C)CCOC(c1ccccc1)c2ccccc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P21 compound treatment 79600.0 -10900.0 -0.09 162160.0 40600.0 0.34 0.1719 0.4931 3189062 SPBio_002239 CN[C@H](C)[C@@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3OC[C@](C)(O)[C@H](NC)[C@H]3O)[C@H]2O)O1.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O)OC[C@]1(C)O.CN[C@@H]1[C@@H](O)[C@@H](O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@@H](CC[C@H]3N)[C@@H](C)N)[C@@H]2O)OC[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P22 compound treatment 66800.0 -23700.0 -0.2 124560.0 3020.0 0.02 -0.1251 -0.6151 1291 SPBio_002240 CCCN(CCC)C(=O)C(CCC(=O)O)NC(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P23 mock treatment 63320.0 -27200.0 -0.23 94520.0 -27000.0 -0.22 -0.3218 -0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2164 P24 mock treatment 50840.0 -39700.0 -0.34 35280.0 -86300.0 -0.71 -0.7435 -0.9416 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A01 mock treatment 58240.0 -37800.0 -0.32 41680.0 -31600.0 -0.26 -0.4128 -0.9947 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A02 mock treatment 111280.0 15200.0 0.13 96520.0 23200.0 0.19 0.2273 0.9817 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A03 compound treatment 134680.0 38600.0 0.33 118600.0 45300.0 0.37 0.4973 0.9979 1425 SPBio_002241 CC(N)COc1c(C)cccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A04 compound treatment 183160.0 87100.0 0.74 168360.0 95000.0 0.79 1.0803 0.9996 3189183 SPBio_002242 CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@@H]3[C@@H](O)[C@H](O)[C@@H](NC(=N)N)[C@H](O)[C@H]3NC(=N)N)O[C@@H](C)[C@]2(O)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A05 compound treatment 207760.0 112000.0 0.95 199080.0 126000.0 1.04 1.4081 0.999 3101 SPBio_002243 Cc1c(oc2c(cccc2c1=O)C(=O)OCCN3CCCCC3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A06 compound treatment 225960.0 130000.0 1.11 222840.0 150000.0 1.24 1.6567 0.9984 3480229 SPBio_002244 COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A07 compound treatment 182880.0 86800.0 0.74 189800.0 116000.0 0.96 1.204 0.9914 769 SPBio_002245 CCCCOc1ccc(CC(=O)NO)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A08 compound treatment 226560.0 130000.0 1.11 233640.0 160000.0 1.33 1.7235 0.9961 1132 SPBio_002246 CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A09 compound treatment 210880.0 115000.0 0.98 207280.0 134000.0 1.11 1.4749 0.998 1469 SPBio_002247 CCC1(CCC(=O)NC1=O)c2ccc(N)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A10 compound treatment 231520.0 135000.0 1.15 267400.0 194000.0 1.61 1.9508 0.9868 3068879 SPBio_002248 C[C@@H](N)[C@H](O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A11 compound treatment 252920.0 157000.0 1.34 235240.0 162000.0 1.34 1.8915 1.0 858 SPBio_002249 OCC(O)CN1CCN(CC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A12 compound treatment 250800.0 155000.0 1.32 253840.0 181000.0 1.49 1.9876 0.998 3068880 SPBio_002250 OCC(O)[C@H]1OC(=O)C(O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A13 compound treatment 228080.0 132000.0 1.12 254080.0 181000.0 1.5 1.8522 0.9901 3173239 SPBio_002251 CC(N/C(=N/C#N)/Nc1ccncc1)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A14 compound treatment 196120.0 100000.0 0.85 196560.0 123000.0 1.02 1.3233 0.996 800 SPBio_002252 C[C@](N)(Cc1ccc(O)c(O)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A15 compound treatment 116680.0 20600.0 0.18 117960.0 44600.0 0.37 0.3852 0.9422 1185085 SPBio_002253 CCCSc1ccc2[nH]c(NC(=O)OC)nc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A16 compound treatment 236640.0 141000.0 1.2 221840.0 149000.0 1.23 1.7151 0.9999 3063 SPBio_002254 CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4C)c5ccc(O)cc5)C(=O)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A17 compound treatment 221920.0 126000.0 1.07 220200.0 147000.0 1.22 1.6169 0.998 448 SPBio_002255 Clc1cccc(Cl)c1N=C2NCCN2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A18 compound treatment 256160.0 160000.0 1.36 235400.0 162000.0 1.34 1.912 1.0 3173242 SPBio_002256 Nc1nc2cc(Cl)ccc2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A19 compound treatment 192880.0 96800.0 0.82 200240.0 127000.0 1.05 1.3253 0.9928 1101055 SPBio_002257 CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A20 compound treatment 156520.0 60500.0 0.51 162920.0 89600.0 0.74 0.8881 0.9841 1516 SPBio_002258 Nc1c2CCCCc2nc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A21 compound treatment 157400.0 61300.0 0.52 127920.0 54600.0 0.45 0.6887 0.9974 690 SPBio_002259 CC(C)NCC(O)COc1ccccc1CC=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A22 compound treatment 133960.0 37900.0 0.32 108160.0 34800.0 0.29 0.4319 0.9984 3487402 SPBio_002260 CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A23 mock treatment 119000.0 22900.0 0.2 66360.0 -6970.0 -0.06 0.0974 0.4781 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 A24 mock treatment 55560.0 -40500.0 -0.34 48680.0 -24600.0 -0.2 -0.388 -0.9686 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B01 mock treatment 126080.0 30000.0 0.26 101360.0 28000.0 0.23 0.3447 0.9988 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B02 mock treatment 182640.0 86600.0 0.74 149200.0 75900.0 0.63 0.9651 0.9968 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B03 compound treatment 142280.0 46200.0 0.39 121200.0 47900.0 0.4 0.5583 1.0 2717 SPBio_002261 CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B04 compound treatment 203240.0 107000.0 0.91 194440.0 121000.0 1.0 1.3538 0.9989 429 SPBio_002262 NCCc1c[nH]c2ccc(O)cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B05 compound treatment 237280.0 141000.0 1.2 214800.0 141000.0 1.17 1.6778 0.9999 1403 SPBio_002263 COC(=O)C1=CCCN(C)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B06 compound treatment 225880.0 130000.0 1.11 228480.0 155000.0 1.28 1.6892 0.9972 1000242 SPBio_002264 CN(C)CCn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4csc(N)n4)C3=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B07 compound treatment 229880.0 134000.0 1.14 245440.0 172000.0 1.42 1.8125 0.9939 1000219 SPBio_002265 N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B08 compound treatment 242000.0 146000.0 1.24 223840.0 151000.0 1.25 1.7591 1.0 3189438 SPBio_002266 Cc1n[nH]c(=O)[nH]c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B09 compound treatment 246800.0 151000.0 1.28 241680.0 168000.0 1.39 1.8923 0.9992 1001661 SPBio_002267 CC(C)CCC[C@H](C)CCC[C@H](C)CCC[C@@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B10 compound treatment 194160.0 98100.0 0.84 209640.0 136000.0 1.13 1.388 0.9891 1077918 SPBio_002268 Fc1ccc(cc1)C(=O)CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B11 compound treatment 267960.0 172000.0 1.46 271360.0 198000.0 1.64 2.1934 0.9984 3189307 SPBio_002269 CC(C)CC(NC(=O)[C@H](C)NC(=O)C[C@H](O)C(CC(C)C)NC(=O)[C@@H](NC(=O)C(NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B12 compound treatment 240560.0 144000.0 1.23 238160.0 165000.0 1.36 1.8342 0.9987 3173761 SPBio_002270 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B13 compound treatment 230160.0 134000.0 1.14 242560.0 169000.0 1.4 1.7973 0.9949 3068973 SPBio_002271 C(CN1CCOCC1)Nc2cc3CCCc4ccccc4-c3nn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B14 compound treatment 228880.0 133000.0 1.13 229960.0 157000.0 1.3 1.7159 0.9977 3189439 SPBio_002272 CC(C)CCCCC(=O)N[C@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@H](CCN)C(=O)N[C@@H]1CCNC(=O)[C@@H](NC(=O)[C@H](CCN)NC(=O)[C@H](CCN)NC(=O)[C@@H](CNC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CCN)NC1=O)C(C)C)[C@@H](C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B15 compound treatment 221440.0 125000.0 1.07 243280.0 170000.0 1.41 1.749 0.9908 1408 SPBio_002273 NC1(CC2CC3CC(C2)C1)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B16 compound treatment 16560.0 -79500.0 -0.68 15440.0 -57900.0 -0.48 -0.8173 -0.9856 2117312 SPBio_002274 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](OC5CC(N)C(O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B17 compound treatment 14560.0 -81500.0 -0.69 13920.0 -59400.0 -0.49 -0.8382 -0.9857 3068976 SPBio_002275 Clc1ccc(CCC(Cn2ccnc2)Sc3c(Cl)cccc3Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B18 compound treatment 175160.0 79100.0 0.67 165440.0 92100.0 0.76 1.0151 0.9981 2911 SPBio_002276 CN(C)CC/C=C\1/c2ccccc2CSc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B19 compound treatment 14800.0 -81300.0 -0.69 21800.0 -51500.0 -0.43 -0.7906 -0.9729 26 SPBio_002277 CCCCc1oc2ccccc2c1C(=O)c3cc(I)c(OCCN(CC)CC)c(I)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B20 compound treatment 252840.0 157000.0 1.33 239800.0 166000.0 1.38 1.9177 0.9999 3189440 SPBio_002278 CC(C)(O/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C[n+]3ccccc3)\c4csc(N)n4)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B21 compound treatment 201520.0 105000.0 0.9 172680.0 99400.0 0.82 1.2161 0.999 2081486 SPBio_002279 CC1OC(O[C@@H]/2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(=O)O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)\C=C\C=C\C=C\C=C\C=C\C=C\C=C2)C(O)C(N)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B22 compound treatment 188320.0 92300.0 0.79 165400.0 92100.0 0.76 1.0941 0.9999 3060173 SPBio_002280 NC(=N)NCc1cccc(I)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B23 mock treatment 204840.0 109000.0 0.93 169640.0 96300.0 0.8 1.2183 0.9972 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 B24 mock treatment 96640.0 579.0 0.0 70560.0 -2770.0 -0.02 -0.0127 -0.5424 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C01 mock treatment 136080.0 40000.0 0.34 100760.0 27400.0 0.23 0.4014 0.9805 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C02 mock treatment 161480.0 65400.0 0.56 148680.0 75400.0 0.62 0.8347 0.9984 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C03 compound treatment 152480.0 56400.0 0.48 113880.0 40600.0 0.34 0.5769 0.9846 1282 SPBio_002281 NS(=O)(=O)c1cc2c(N=CNS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C04 compound treatment 158840.0 62800.0 0.53 136560.0 63200.0 0.52 0.7479 0.9999 907527 SPBio_002282 C(C#CCN1CCCC1)N2CCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C05 compound treatment 206640.0 111000.0 0.94 196960.0 124000.0 1.02 1.389 0.9991 3036 SPBio_002283 OC(CCCN1CCCCC1)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C06 compound treatment 248520.0 152000.0 1.3 238120.0 165000.0 1.36 1.8819 0.9997 1486 SPBio_002284 CC(C)NCC(O)COc1ccc(NC(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C07 compound treatment 229480.0 133000.0 1.14 233880.0 161000.0 1.33 1.7424 0.997 1000286 SPBio_002285 C[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C08 compound treatment 231400.0 135000.0 1.15 254040.0 181000.0 1.49 1.8719 0.9917 3189185 SPBio_002286 Cc1cn([C@H]2C[C@@H](N=[N+]=N)[C@@H](CO)O2)c(=O)[nH]c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C09 compound treatment 220080.0 124000.0 1.06 240040.0 167000.0 1.38 1.7219 0.9913 809 SPBio_002287 CNCCC=C1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C10 compound treatment 241920.0 146000.0 1.24 245320.0 172000.0 1.42 1.8843 0.9977 1192 SPBio_002288 Cc1noc(NS(=O)(=O)c2ccc(N)cc2)c1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C11 compound treatment 207480.0 111000.0 0.95 223760.0 150000.0 1.24 1.5508 0.991 112 SPBio_002289 OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C12 compound treatment 215720.0 120000.0 1.02 236040.0 163000.0 1.35 1.6722 0.9906 3068881 SPBio_002290 CCCOc1ccccc1c2nc(=O)c3[nH]nnc3[nH]2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C13 compound treatment 137120.0 41100.0 0.35 127480.0 54200.0 0.45 0.564 0.9925 1000009 SPBio_002291 C/C(=C\C=C\C(=C/C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C14 compound treatment 244960.0 149000.0 1.27 224800.0 151000.0 1.25 1.7825 1.0 1471 SPBio_002292 CN1C(c2ccc(Cl)cc2)S(=O)(=O)CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C15 compound treatment 66520.0 -29500.0 -0.25 67080.0 -6250.0 -0.05 -0.2144 -0.8349 104 SPBio_002293 C/C(=C\C=C\C(=C\C(=O)O)\C)/C=C/C1=C(C)CCCC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C16 compound treatment 228680.0 133000.0 1.13 226400.0 153000.0 1.27 1.6939 0.9984 2431 SPBio_002294 CCN(CC)CCNC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C17 compound treatment 217400.0 121000.0 1.03 204720.0 131000.0 1.09 1.4991 0.9997 746 SPBio_002295 C(N(Cc1ccccc1)c2ccccc2)C3=NCCN3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C18 compound treatment 188080.0 92000.0 0.78 209440.0 136000.0 1.13 1.3502 0.9843 3189186 SPBio_002296 CNc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C19 compound treatment 88680.0 -7380.0 -0.06 53800.0 -19500.0 -0.16 -0.1587 -0.9154 1485 SPBio_002297 CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C20 compound treatment 110400.0 14300.0 0.12 109520.0 36200.0 0.3 0.2981 0.9217 3368 SPBio_002298 NC(=N)NC(=O)Cc1c(Cl)cccc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C21 compound treatment 188000.0 91900.0 0.78 182840.0 110000.0 0.91 1.1941 0.9974 1000106 SPBio_002299 O=C(C1CCCCC1)N2CC3N(CCc4ccccc34)C(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C22 compound treatment 12520.0 -83500.0 -0.71 10240.0 -63100.0 -0.52 -0.872 -0.9884 1001939 SPBio_002300 OCCN1CCN(CC/C=C\2/c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C23 mock treatment 154080.0 58000.0 0.49 119120.0 45800.0 0.38 0.6172 0.9914 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 C24 mock treatment 97920.0 1860.0 0.02 31280.0 -42000.0 -0.35 -0.2348 -0.6742 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D01 mock treatment 122200.0 26100.0 0.22 93120.0 19800.0 0.16 0.2732 0.9886 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D02 mock treatment 113280.0 17200.0 0.15 103600.0 30300.0 0.25 0.2808 0.9675 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D03 compound treatment 112000.0 15900.0 0.14 76880.0 3550.0 0.03 0.1168 0.8408 3189308 SPBio_002301 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4C[C@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D04 compound treatment 78640.0 -17400.0 -0.15 76360.0 3030.0 0.03 -0.0871 -0.5792 2120971 SPBio_002302 CN1CCCC(CC2c3ccccc3Sc4ccccc24)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D05 compound treatment 15920.0 -80100.0 -0.68 15200.0 -58100.0 -0.48 -0.8225 -0.9853 2117676 SPBio_002303 COc1ccc(C[C@@H]2NC[C@@H](O)[C@@H]2OC(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D06 compound treatment 251120.0 155000.0 1.32 252800.0 179000.0 1.48 1.9834 0.9983 3172716 SPBio_002304 NC(=O)N/N=C/c1ccc(o1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D07 compound treatment 224280.0 128000.0 1.09 231960.0 159000.0 1.31 1.6999 0.9958 1023517 SPBio_002305 NC(=O)Nc1ccc(cc1)[As](=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D08 compound treatment 229480.0 133000.0 1.14 211120.0 138000.0 1.14 1.6093 1.0 1782 SPBio_002306 COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D09 compound treatment 175120.0 79100.0 0.67 201480.0 128000.0 1.06 1.2256 0.976 360 SPBio_002307 Oc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D10 compound treatment 245080.0 149000.0 1.27 244240.0 171000.0 1.41 1.897 0.9985 912 SPBio_002308 CCCc1cc(=O)[nH]c(=S)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D11 compound treatment 236760.0 141000.0 1.2 249320.0 176000.0 1.46 1.8766 0.9953 1064663 SPBio_002309 CC(=O)NC(CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D12 compound treatment 100320.0 4260.0 0.04 100600.0 27300.0 0.23 0.1852 0.8103 3189441 SPBio_002310 CC(C)N1CCN(CC1)c2ccc(OC[C@@H]3CO[C@](Cn4cncn4)(O3)c5ccc(Cl)cc5Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D13 compound treatment 268320.0 172000.0 1.47 250240.0 177000.0 1.46 2.072 1.0 3189309 SPBio_002311 CCOC(=O)OC(C)OC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D14 compound treatment 165320.0 69300.0 0.59 204160.0 131000.0 1.08 1.1823 0.9592 3487464 SPBio_002312 CC(C(=O)O)c1ccc(s1)C(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D15 compound treatment 51280.0 -44800.0 -0.38 60360.0 -13000.0 -0.11 -0.3455 -0.8722 1960 SPBio_002313 CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D16 compound treatment 243360.0 147000.0 1.25 221760.0 148000.0 1.23 1.7551 0.9999 3177604 SPBio_002314 CN[C@H](CC(C)C)C(=O)N[C@@H]1[C@H](O)c2ccc(Oc3cc4cc(Oc5ccc(cc5Cl)[C@@H](O)[C@@H]6NC(=O)[C@H](NC(=O)[C@@H]4NC(=O)[C@H](CC(=O)N)NC1=O)c7ccc(O)c(c7)-c8c(O)cc(O)cc8[C@H](NC6=O)C(=O)O)c3O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O[C@H]%10C[C@](C)(N)[C@H](O)[C@H](C)O%10)c(Cl)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D17 compound treatment 229000.0 133000.0 1.13 225560.0 152000.0 1.26 1.6909 0.9986 951 SPBio_002315 OC(=O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D18 compound treatment 232600.0 137000.0 1.16 213480.0 140000.0 1.16 1.6419 1.0 1263 SPBio_002316 C[C@@H]1CC[C@H]2[C@@H](C)C(=O)O[C@@H]3O[C@@]4(C)CC[C@@H]1[C@@]23OO4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D19 compound treatment 123800.0 27700.0 0.24 151720.0 78400.0 0.65 0.6256 0.9064 982 SPBio_002317 CC(=O)Oc1ccc(cc1)C(c2ccc(OC(=O)C)cc2)c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D20 compound treatment 178120.0 82100.0 0.7 180680.0 107000.0 0.89 1.122 0.9929 1489 SPBio_002318 CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D21 compound treatment 147840.0 51800.0 0.44 152560.0 79200.0 0.66 0.7752 0.9814 3189310 SPBio_002319 CC(C)[C@H](C)/C=C/[C@@H](C)[C@H]1CC[C@H]2\C(=C\C=C/3\C[C@H](O)CCC3=C)\CCC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D22 compound treatment 163560.0 67500.0 0.57 120720.0 47400.0 0.39 0.6836 0.9826 1113307 SPBio_002320 CCN(CC)C(=O)c1ccc(O)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D23 mock treatment 146320.0 50300.0 0.43 103800.0 30500.0 0.25 0.4808 0.9682 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 D24 mock treatment 69720.0 -26300.0 -0.22 37800.0 -35500.0 -0.29 -0.3664 -0.9911 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E01 mock treatment 146800.0 50700.0 0.43 133120.0 59800.0 0.49 0.6553 0.9977 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E02 mock treatment 131840.0 35800.0 0.3 97440.0 24100.0 0.2 0.3565 0.9789 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E03 compound treatment 154760.0 58700.0 0.5 115080.0 41800.0 0.35 0.5976 0.9837 3189178 SPBio_002321 C[C@@]12CCC3C(CCC4=CC(=O)CC[C@]34C)C2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E04 compound treatment 205600.0 110000.0 0.93 203000.0 130000.0 1.07 1.418 0.9976 1188 SPBio_002322 NS(=O)(=O)c1cc(C(=O)O)c(NCc2ccco2)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E05 compound treatment 187400.0 91300.0 0.78 169600.0 96300.0 0.8 1.1131 0.9999 938 SPBio_002323 Cc1ccc(cc1)/C(=C\CN2CCCC2)/c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E06 compound treatment 202520.0 106000.0 0.91 192240.0 119000.0 0.98 1.3365 0.9992 1510 SPBio_002324 CN(C)CCN(Cc1cccs1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E07 compound treatment 209680.0 114000.0 0.97 195680.0 122000.0 1.01 1.3998 0.9997 3060494 SPBio_002325 CN(C)CC/C=C/1\c2ccccc2COc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E08 compound treatment 240440.0 144000.0 1.23 226840.0 154000.0 1.27 1.7672 0.9999 844 SPBio_002326 CNCCCN1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E09 compound treatment 27800.0 -68300.0 -0.58 28680.0 -44600.0 -0.37 -0.6721 -0.9761 1240 SPBio_002327 CCCCOc1ccc(cc1)C(=O)CCN2CCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E10 compound treatment 247880.0 152000.0 1.29 234440.0 161000.0 1.33 1.8565 0.9999 2203 SPBio_002328 CN(CCCOc1ccc(Cl)cc1Cl)CC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E11 compound treatment 368720.0 273000.0 2.32 248240.0 175000.0 1.45 2.6647 0.9741 3189179 SPBio_002329 CN(C)CCOC(c1ccccc1)c2ccccc2.Cn1c(=O)n(C)c2nc(Cl)[n-]c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E12 compound treatment 231200.0 135000.0 1.15 220480.0 147000.0 1.22 1.6744 0.9996 1390 SPBio_002330 CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E13 compound treatment 313240.0 217000.0 1.85 252840.0 180000.0 1.49 2.3576 0.9941 1112 SPBio_002331 CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E14 compound treatment 224440.0 128000.0 1.09 215840.0 143000.0 1.18 1.6066 0.9993 1476 SPBio_002332 CNCCCC1(CCC2c3ccccc31)c4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E15 compound treatment 113000.0 16900.0 0.14 125640.0 52300.0 0.43 0.408 0.8944 1272 SPBio_002333 Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E16 compound treatment 92600.0 -3460.0 -0.03 92640.0 19300.0 0.16 0.0921 0.5671 3189187 SPBio_002334 Nc1nc(S)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E17 compound treatment 141560.0 45500.0 0.39 147760.0 74400.0 0.62 0.7093 0.9751 2359 SPBio_002335 CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@@H]32)n1c5ccccc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E18 compound treatment 184080.0 88000.0 0.75 186320.0 113000.0 0.93 1.1909 0.994 3068882 SPBio_002336 CN(C)CC/C=C\1/c2ccccc2Sc3ccc(Cl)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E19 compound treatment 194600.0 98500.0 0.84 180440.0 107000.0 0.89 1.2198 0.9996 1393 SPBio_002337 CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E20 compound treatment 213840.0 118000.0 1.0 206400.0 133000.0 1.1 1.4875 0.9989 1000292 SPBio_002338 C[C@H](NCCc1ccc(O)cc1)[C@H](O)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E21 compound treatment 44920.0 -51100.0 -0.44 75040.0 1710.0 0.01 -0.2979 -0.6837 1215 SPBio_002339 CC(NCCC(c1ccccc1)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E22 compound treatment 141840.0 45800.0 0.39 120680.0 47400.0 0.39 0.5526 1.0 417 SPBio_002340 CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E23 mock treatment 168560.0 72500.0 0.62 114760.0 41400.0 0.34 0.6789 0.9615 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 E24 mock treatment 81320.0 -14700.0 -0.13 41080.0 -32200.0 -0.27 -0.2774 -0.9409 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F01 mock treatment 169680.0 73600.0 0.63 182680.0 109000.0 0.9 1.0829 0.9839 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F02 mock treatment 119040.0 23000.0 0.2 98680.0 25400.0 0.21 0.2867 0.9994 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F03 compound treatment 12640.0 -83400.0 -0.71 11320.0 -62000.0 -0.51 -0.865 -0.9872 998 SPBio_002341 CCCCCCCCNC(C)C(O)c1ccc(SC(C)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F04 compound treatment 218840.0 123000.0 1.05 206280.0 133000.0 1.1 1.5169 0.9997 1002022 SPBio_002342 NC(CCC(=O)O)C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F05 compound treatment 219400.0 123000.0 1.05 237480.0 164000.0 1.36 1.7028 0.9919 3069011 SPBio_002343 NCCC(=O)NCCc1c[nH]cn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F06 compound treatment 210200.0 114000.0 0.97 201880.0 129000.0 1.06 1.4392 0.999 2121358 SPBio_002344 OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F07 compound treatment 252720.0 157000.0 1.33 238360.0 165000.0 1.37 1.9086 0.9999 1409 SPBio_002345 CCCC(C)(COC(=O)N)COC(=O)NC(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F08 compound treatment 299080.0 203000.0 1.73 234480.0 161000.0 1.33 2.165 0.9918 3487465 SPBio_002346 OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F09 compound treatment 245400.0 149000.0 1.27 286160.0 213000.0 1.76 2.1441 0.9872 3189311 SPBio_002347 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](N)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F10 compound treatment 297520.0 201000.0 1.72 264520.0 191000.0 1.58 2.3313 0.9992 3189442 SPBio_002348 CCc1cccc(CC)c1NC(=O)CN(CC(=O)O)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F11 compound treatment 195600.0 99500.0 0.85 212280.0 139000.0 1.15 1.4121 0.9888 2117409 SPBio_002349 COc1cc(ccc1N=Nc2ccc3c(cc(c(N)c3c2O)S(=O)(=O)O)S(=O)(=O)O)c4ccc(N=Nc5ccc6c(cc(c(N)c6c5O)S(=O)(=O)O)S(=O)(=O)O)c(OC)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F12 compound treatment 255360.0 159000.0 1.36 252840.0 180000.0 1.49 2.0092 0.999 1252 SPBio_002350 CC(C)NCC(O)c1cc(O)cc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F13 compound treatment 347880.0 252000.0 2.14 252640.0 179000.0 1.48 2.565 0.9838 907205 SPBio_002351 COc1cc(OC)c(C(=O)CCCN2CCCC2)c(OC)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F14 compound treatment 260520.0 164000.0 1.4 226360.0 153000.0 1.27 1.8853 0.9987 2080587 SPBio_002352 CNC1C(O)C(OC2C(N)CC(N)C(OC3OC(=CCC3N)CN)C2O)OCC1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F15 compound treatment 205720.0 110000.0 0.93 198720.0 125000.0 1.04 1.3937 0.9986 3173763 SPBio_002353 O[C@@H]1C[C@](O)(C[C@@H](OC(=O)/C=C/c2ccc(O)c(O)c2)[C@@H]1O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F16 compound treatment 280520.0 184000.0 1.57 250360.0 177000.0 1.46 2.1461 0.9994 353 SPBio_002354 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F17 compound treatment 17560.0 -78500.0 -0.67 16720.0 -56600.0 -0.47 -0.8037 -0.9849 3180147 SPBio_002355 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1C[C@H]4NCCc5cc(O)c(OC)cc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F18 compound treatment 113600.0 17500.0 0.15 112400.0 39100.0 0.32 0.3342 0.9385 2269 SPBio_002356 Oc1ccc(/C=C/c2cc(O)cc(O)c2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F19 compound treatment 224640.0 129000.0 1.09 219680.0 146000.0 1.21 1.6302 0.9987 3189312 SPBio_002357 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2/C(=C/C=C\3/C[C@H](O)CCC3=C)/CCC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F20 compound treatment 101480.0 5420.0 0.05 99640.0 26300.0 0.22 0.1866 0.8383 2922 SPBio_002358 OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c3ccc(Br)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F21 compound treatment 165880.0 69800.0 0.59 172240.0 98900.0 0.82 0.999 0.9877 3487430 SPBio_002359 COC1CN(CCCOc2ccc(F)cc2)CCC1NC(=O)c3cc(Cl)c(N)cc3OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F22 compound treatment 167240.0 71200.0 0.61 142200.0 68900.0 0.57 0.8314 0.9995 1000807 SPBio_002360 CN1CCN(CC1)C(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F23 mock treatment 153200.0 57100.0 0.49 125240.0 51900.0 0.43 0.6477 0.9981 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 F24 mock treatment 70120.0 -25900.0 -0.22 29800.0 -43500.0 -0.36 -0.4108 -0.9725 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G01 mock treatment 113720.0 17700.0 0.15 80200.0 6870.0 0.06 0.1465 0.9115 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G02 mock treatment 122880.0 26800.0 0.23 93120.0 19800.0 0.16 0.2773 0.9867 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G03 compound treatment 110040.0 14000.0 0.12 86640.0 13300.0 0.11 0.162 0.9993 3069234 SPBio_002361 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@](O)(C(=O)OC)n4c5ccccc35 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G04 compound treatment 196080.0 100000.0 0.85 172000.0 98700.0 0.82 1.1794 0.9998 1332 SPBio_002362 NS(=O)(=O)c1cc(ccc1Cl)C2(O)NC(=O)c3ccccc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G05 compound treatment 194560.0 98500.0 0.84 186320.0 113000.0 0.93 1.254 0.9985 2797 SPBio_002363 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G06 compound treatment 212480.0 116000.0 0.99 204440.0 131000.0 1.08 1.4679 0.999 3480458 SPBio_002364 CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G07 compound treatment 215360.0 119000.0 1.02 226280.0 153000.0 1.27 1.613 0.9941 3176928 SPBio_002365 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G08 compound treatment 244400.0 148000.0 1.26 240280.0 167000.0 1.38 1.8697 0.999 1048 SPBio_002366 CCn1cc(C(=O)O)c(=O)c2cc(F)c(nc12)N3CCNCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G09 compound treatment 296680.0 201000.0 1.71 249680.0 176000.0 1.46 2.2394 0.9969 3189180 SPBio_002367 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)C=C[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G10 compound treatment 249440.0 153000.0 1.31 228040.0 155000.0 1.28 1.8284 0.9999 1526 SPBio_002368 CC1CCCC(C)N1NC(=O)c2ccc(Cl)c(c2)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G11 compound treatment 236000.0 140000.0 1.19 204720.0 131000.0 1.09 1.6111 0.999 1172 SPBio_002369 CC(C)OC(=O)C(C)(C)Oc1ccc(cc1)C(=O)c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G12 compound treatment 146120.0 50100.0 0.43 128120.0 54800.0 0.45 0.6219 0.9995 1105 SPBio_002370 CCN(CC)CCNc1ccc(CO)c2sc3ccccc3c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G13 compound treatment 281400.0 185000.0 1.58 236560.0 163000.0 1.35 2.0707 0.997 404 SPBio_002371 CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G14 compound treatment 204920.0 109000.0 0.93 216800.0 143000.0 1.19 1.4947 0.9925 3068883 SPBio_002372 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G15 compound treatment 211600.0 116000.0 0.98 217960.0 145000.0 1.2 1.5417 0.9953 1100 SPBio_002373 CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G16 compound treatment 228760.0 133000.0 1.13 204840.0 132000.0 1.09 1.5682 0.9998 3189189 SPBio_002374 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G17 compound treatment 181360.0 85300.0 0.73 167480.0 94200.0 0.78 1.0643 0.9994 3172 SPBio_002375 C(/C=C/c1ccccc1)N2CCN(CC2)C(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G18 compound treatment 247120.0 151000.0 1.29 217200.0 144000.0 1.19 1.7511 0.9993 1000342 SPBio_002376 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G19 compound treatment 227720.0 132000.0 1.12 210240.0 137000.0 1.13 1.5936 1.0 1001967 SPBio_002377 C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G20 compound treatment 183200.0 87100.0 0.74 190240.0 117000.0 0.97 1.2085 0.9914 1000343 SPBio_002378 COc1ccc2C[C@H]3[C@H]4CCCC[C@@]4(CCN3C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G21 compound treatment 175080.0 79000.0 0.67 169800.0 96500.0 0.8 1.0401 0.9964 3177396 SPBio_002379 COc1ccc2nccc([C@H](O)[C@H]3CC4CCN3C[C@@H]4C=C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G22 compound treatment 160160.0 64100.0 0.55 127480.0 54200.0 0.45 0.7027 0.9952 764 SPBio_002380 Fc1ccc(cc1)C(=O)CCCN2CCC(=CC2)n3c(=O)[nH]c4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G23 mock treatment 176120.0 80100.0 0.68 113520.0 40200.0 0.33 0.7171 0.9455 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 G24 mock treatment 48720.0 -47300.0 -0.4 25320.0 -48000.0 -0.4 -0.5658 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H01 mock treatment 75720.0 -20300.0 -0.17 48560.0 -24800.0 -0.2 -0.2673 -0.9965 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H02 mock treatment 111320.0 15300.0 0.13 87040.0 13700.0 0.11 0.1721 0.9977 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H03 compound treatment 122000.0 25900.0 0.22 132360.0 59000.0 0.49 0.5015 0.9356 1055132 SPBio_002381 COc1cc2cc[n+]3c(C)c4cc(OC)c(OC)cc4cc3c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H04 compound treatment 71480.0 -24600.0 -0.21 69520.0 -3810.0 -0.03 -0.1703 -0.8044 1095093 SPBio_002382 CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H05 compound treatment 156760.0 60700.0 0.52 134600.0 61300.0 0.51 0.7239 1.0 3054850 SPBio_002383 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H06 compound treatment 258640.0 163000.0 1.38 224680.0 151000.0 1.25 1.8642 0.9987 2141046 SPBio_002384 CC(=O)N(CC(O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H07 compound treatment 227120.0 131000.0 1.12 196720.0 123000.0 1.02 1.5109 0.999 3189313 SPBio_002385 C[C@H](CNC(=O)CC[C@]1(C)[C@@H](CC(=O)N)[C@H]2N=C1/C(=C/3\N=C(/C=C/4\N=C(/C(=C\5/[C@@H](CCC(=O)N)[C@](C)(CC(=O)N)[C@@]2(C)N5[Co+]C#N)/C)\[C@@](C)(CC(=O)N)[C@@H]4CCC(=O)N)\C(C)(C)[C@@H]3CCC(=O)N)/C)OP(=O)(O)O[C@H]6[C@@H](O)[C@H](O[C@@H]6CO)n7cnc8cc(C)c(C)cc78 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H08 compound treatment 224840.0 129000.0 1.1 196800.0 123000.0 1.02 1.4976 0.9994 3068692 SPBio_002386 CNCCC=C1c2ccccc2C=Cc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H09 compound treatment 266560.0 170000.0 1.45 246360.0 173000.0 1.43 2.0387 1.0 1037 SPBio_002387 CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c3ccc(O)cc3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H10 compound treatment 243840.0 148000.0 1.26 232800.0 159000.0 1.32 1.8226 0.9997 889 SPBio_002388 NC(=O)c1cnccn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H11 compound treatment 192840.0 96800.0 0.82 204520.0 131000.0 1.09 1.3501 0.9908 3069049 SPBio_002389 CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C/C=C/C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H12 compound treatment 251720.0 156000.0 1.33 214800.0 141000.0 1.17 1.7647 0.9981 2900 SPBio_002390 CN1C(=O)OC(C)(C)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H13 compound treatment 36440.0 -59600.0 -0.51 33080.0 -40200.0 -0.33 -0.5944 -0.9791 3189314 SPBio_002391 C[C@@]12CC[C@H]3[C@@H](CC[C@@H]4C[C@@H](O)CC[C@@]43C)[C@@]2(O)CC[C@@H]1C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H14 compound treatment 82920.0 -13100.0 -0.11 75440.0 2110.0 0.02 -0.0667 -0.5894 1607 SPBio_002392 CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H15 compound treatment 30360.0 -65700.0 -0.56 31600.0 -41700.0 -0.35 -0.6396 -0.9731 3189315 SPBio_002393 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@@H]2[C@@H](C)O[C@H](C[C@@H]2O)O[C@@H]3[C@@H](C)O[C@H](C[C@@H]3O)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H16 compound treatment 237360.0 141000.0 1.2 166000.0 92700.0 0.77 1.3928 0.9763 3189443 SPBio_002394 CC1OC(OC/2CC3O[C@@](O)(CC(O)C3C(=O)O)CC(O)C(O)CCC(O)CC(O)CC(O)CC(=O)O[C@@H](C)[C@H](C)[C@H](O)[C@@H](C)/C=C/C=C/CC\C=C\C=C\C=C\C=C2)C(O)C(N)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H17 compound treatment 16520.0 -79500.0 -0.68 13400.0 -59900.0 -0.5 -0.8294 -0.9882 1000279 SPBio_002395 COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H18 compound treatment 217760.0 122000.0 1.04 200960.0 128000.0 1.06 1.4793 1.0 3060147 SPBio_002396 CCCC1O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H19 compound treatment 219200.0 123000.0 1.05 223840.0 151000.0 1.25 1.6218 0.9963 3069053 SPBio_002397 CCOC(=O)n1ccn(C)c1=S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H20 compound treatment 201440.0 105000.0 0.9 201080.0 128000.0 1.06 1.3818 0.9967 3068724 SPBio_002398 C[C@@H](O)[C@@H]1[C@H]2CC(=C(N2C1=O)C(=O)O)SCCNC=N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H21 compound treatment 116240.0 20200.0 0.17 113360.0 40000.0 0.33 0.3557 0.9533 1001924 SPBio_002399 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H22 compound treatment 179520.0 83500.0 0.71 170400.0 97100.0 0.8 1.0703 0.9981 1448 SPBio_002400 OC(=O)c1cc(N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H23 mock treatment 177920.0 81900.0 0.7 114440.0 41100.0 0.34 0.7333 0.9456 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 H24 mock treatment 50200.0 -45900.0 -0.39 26040.0 -47300.0 -0.39 -0.5527 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I01 mock treatment 62920.0 -33100.0 -0.28 42080.0 -31200.0 -0.26 -0.3823 -0.999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I02 mock treatment 85960.0 -10100.0 -0.09 79840.0 6510.0 0.05 -0.0227 -0.2237 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I03 compound treatment 145480.0 49400.0 0.42 111640.0 38300.0 0.32 0.5217 0.9902 1000235 SPBio_002401 CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I04 compound treatment 173920.0 77900.0 0.66 175640.0 102000.0 0.85 1.0673 0.9927 3189191 SPBio_002402 CN(C)C(=O)Oc1cc(OC(=O)N(C)C)cc(c1)C(O)CNC(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I05 compound treatment 218360.0 122000.0 1.04 219440.0 146000.0 1.21 1.591 0.9972 1033 SPBio_002403 CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I06 compound treatment 216440.0 120000.0 1.02 219520.0 146000.0 1.21 1.5799 0.9966 3068885 SPBio_002404 C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I07 compound treatment 81680.0 -14400.0 -0.12 94920.0 21600.0 0.18 0.0397 0.1835 1019722 SPBio_002405 CN1CCCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I08 compound treatment 144520.0 48500.0 0.41 140560.0 67200.0 0.56 0.685 0.9892 1352 SPBio_002406 COc1cc2CC[C@H](NC(=O)C)c3cc(=O)c(OC)ccc3-c2c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I09 compound treatment 216680.0 121000.0 1.03 203760.0 130000.0 1.08 1.4892 0.9997 1164 SPBio_002407 CCN(CC)C(=O)N1CCN(C)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I10 compound treatment 139000.0 42900.0 0.37 103320.0 30000.0 0.25 0.434 0.9822 3177235 SPBio_002408 CN1C[C@H](CNC(=O)OCc2ccccc2)C[C@H]3[C@H]1Cc4cn(C)c5cccc3c45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I11 compound treatment 234360.0 138000.0 1.18 198680.0 125000.0 1.04 1.5659 0.998 1000071 SPBio_002409 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I12 compound treatment 253480.0 157000.0 1.34 242520.0 169000.0 1.4 1.9375 0.9998 3189192 SPBio_002410 CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(cc12)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I13 compound treatment 22680.0 -73400.0 -0.62 27360.0 -46000.0 -0.38 -0.7107 -0.9717 1158 SPBio_002411 C(C(C1CCCCC1)C2CCCCC2)C3CCCCN3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I14 compound treatment 183560.0 87500.0 0.74 147200.0 73900.0 0.61 0.9589 0.9952 701 SPBio_002412 Nc1c(Br)cc(Br)cc1CNC2CCC(O)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I15 compound treatment 81360.0 -14700.0 -0.13 55400.0 -17900.0 -0.15 -0.1934 -0.9964 3480597 SPBio_002413 CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I16 compound treatment 36560.0 -59500.0 -0.51 30160.0 -43200.0 -0.36 -0.6107 -0.9853 705 SPBio_002414 CC(Cc1cccc(c1)C(F)(F)F)NCCOC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I17 compound treatment 93200.0 -2860.0 -0.02 75760.0 2430.0 0.02 -0.003 -0.0945 1180 SPBio_002415 Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I18 compound treatment 49280.0 -46800.0 -0.4 42800.0 -30500.0 -0.25 -0.4602 -0.9758 1000048 SPBio_002416 CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I19 compound treatment 163480.0 67400.0 0.57 154880.0 81600.0 0.67 0.883 0.9968 830 SPBio_002417 COc1ccc(CN(CCN(C)C)c2ccccn2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I20 compound treatment 182680.0 86600.0 0.74 177680.0 104000.0 0.86 1.1319 0.9969 1504 SPBio_002418 O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I21 compound treatment 193200.0 97100.0 0.83 179720.0 106000.0 0.88 1.2072 0.9995 753 SPBio_002419 O=C1C(CCS(=O)c2ccccc2)C(=O)N(N1c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I22 compound treatment 36080.0 -60000.0 -0.51 43480.0 -29800.0 -0.25 -0.5357 -0.9444 2873 SPBio_002420 CCc1oc2ccccc2c1C(=O)c3cc(Br)c(O)c(Br)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I23 mock treatment 159960.0 63900.0 0.54 89440.0 16100.0 0.13 0.479 0.8551 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 I24 mock treatment 36680.0 -59400.0 -0.51 24320.0 -49000.0 -0.41 -0.6442 -0.994 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J01 mock treatment 49160.0 -46900.0 -0.4 29320.0 -44000.0 -0.36 -0.5398 -0.9989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J02 mock treatment 78760.0 -17300.0 -0.15 57080.0 -16200.0 -0.13 -0.1992 -0.999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J03 compound treatment 93360.0 -2700.0 -0.02 69720.0 -3610.0 -0.03 -0.0374 -0.9917 386 SPBio_002421 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2CC[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J04 compound treatment 185000.0 88900.0 0.76 160360.0 87000.0 0.72 1.0446 0.9997 821975 SPBio_002422 C[C@H](CCC(=O)NCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J05 compound treatment 183040.0 87000.0 0.74 157280.0 84000.0 0.69 1.0148 0.9995 2078 SPBio_002423 CCCCc1ccc(nc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J06 compound treatment 55240.0 -40800.0 -0.35 54960.0 -18400.0 -0.15 -0.3532 -0.9311 3189444 SPBio_002424 CCC(C)C1NC2C=Cc3c(cc(nc3C2O)C(=O)OC(C)C4NC(=O)c5csc(n5)C(NC(=O)C6CSC(=N6)/C(=C\C)/NC(=O)C(NC(=O)c7csc(n7)C8(CCC(=NC8c9csc4n9)c%10nc(cs%10)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)NC(=O)C(C)NC(=O)C(=C)NC(=O)C(C)NC1=O)C(C)O)C(C)(O)C(C)O)C(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J07 compound treatment 195560.0 99500.0 0.85 174240.0 101000.0 0.83 1.1894 1.0 3189316 SPBio_002425 COc1ccc(cc1)c2ccc(=N)n(CCCC(=O)O)n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J08 compound treatment 215640.0 120000.0 1.02 165200.0 91900.0 0.76 1.2574 0.9896 3068727 SPBio_002426 C[S+](=N)([O-])CC[C@H](N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J09 compound treatment 241400.0 145000.0 1.24 198120.0 125000.0 1.03 1.605 0.9959 3189317 SPBio_002427 C[C@@H]1C(=O)O[C@H]2CC34[C@H]5C[C@@H](C(C)(C)C)C46[C@@H](O)C(=O)O[C@H]6OC3(C(=O)O5)[C@@]12O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J10 compound treatment 210800.0 115000.0 0.98 204400.0 131000.0 1.08 1.4575 0.9986 737 SPBio_002428 c1nc(cs1)c2nc3ccccc3[nH]2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J11 compound treatment 188840.0 92800.0 0.79 179800.0 106000.0 0.88 1.1814 0.9985 716 SPBio_002429 CN(C)CCC=C1c2ccccc2C=Cc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J12 compound treatment 232960.0 137000.0 1.17 226800.0 153000.0 1.27 1.722 0.9991 3189445 SPBio_002430 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4c(O)c(/C=N/N5CCN(C)CC5)c(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)c(O)c4c(O)c3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J13 compound treatment 231280.0 135000.0 1.15 240200.0 167000.0 1.38 1.7902 0.9959 1300555 SPBio_002431 CC(C)(C)NCC(O)COc1cccc2NC(=O)CCc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J14 compound treatment 197400.0 101000.0 0.86 193720.0 120000.0 1.0 1.3144 0.9974 803 SPBio_002432 CCc1cc(ccn1)C(=S)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J15 compound treatment 134960.0 38900.0 0.33 137200.0 63900.0 0.53 0.6078 0.9747 2080102 SPBio_002433 C[C@@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J16 compound treatment 168040.0 72000.0 0.61 126800.0 53500.0 0.44 0.7462 0.9872 900 SPBio_002434 CN1C(=C(O)c2sccc2S1(=O)=O)C(=O)Nc3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J17 compound treatment 195040.0 99000.0 0.84 160480.0 87200.0 0.72 1.1057 0.997 3069083 SPBio_002435 Nc1c2ccccc2nc3c(O)cccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J18 compound treatment 207640.0 112000.0 0.95 197320.0 124000.0 1.03 1.3971 0.9993 3068731 SPBio_002436 CC(=O)Oc1cc(ccc1C(=O)O)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J19 compound treatment 207640.0 112000.0 0.95 196600.0 123000.0 1.02 1.3929 0.9994 992 SPBio_002437 CC[C@H]1[C@@H](Cc2cncn2C)COC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J20 compound treatment 167160.0 71100.0 0.61 152720.0 79400.0 0.66 0.8925 0.9992 4379 SPBio_002438 CN1CCCCC1CCN2c3ccccc3Sc4ccc(cc24)S(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J21 compound treatment 188720.0 92700.0 0.79 161720.0 88400.0 0.73 1.0749 0.9993 1265 SPBio_002439 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4c(Cl)cccc4Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J22 compound treatment 126280.0 30200.0 0.26 115880.0 42600.0 0.35 0.4309 0.9881 1470254 SPBio_002440 Cc1c(C)c2OC(C)(CCc2c(C)c1O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J23 mock treatment 133400.0 37300.0 0.32 95400.0 22100.0 0.18 0.3539 0.9654 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 J24 mock treatment 40160.0 -55900.0 -0.48 37560.0 -35800.0 -0.3 -0.5458 -0.9738 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K01 mock treatment 39440.0 -56600.0 -0.48 23520.0 -49800.0 -0.41 -0.6322 -0.9969 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K02 mock treatment 73160.0 -22900.0 -0.19 75120.0 1790.0 0.01 -0.1274 -0.6514 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K03 compound treatment 114080.0 18000.0 0.15 66120.0 -7210.0 -0.06 0.0663 0.403 3068677 SPBio_002441 OC1=NC(=O)CN1/N=C/c2ccc(o2)c3ccc(cc3)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K04 compound treatment 166600.0 70500.0 0.6 139840.0 66500.0 0.55 0.8138 0.999 771 SPBio_002442 CN1CCC(=C2c3ccsc3C(=O)Cc4ccccc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K05 compound treatment 119480.0 23400.0 0.2 84800.0 11500.0 0.09 0.2081 0.9424 850 SPBio_002443 Clc1cccc(c1)N2CCN(CCCn3nc4ccccn4c3=O)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K06 compound treatment 191800.0 95700.0 0.82 188160.0 115000.0 0.95 1.2481 0.9971 907283 SPBio_002444 NC(=N)N1CCc2ccccc2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K07 compound treatment 114640.0 18600.0 0.16 84520.0 11200.0 0.09 0.1773 0.9675 936 SPBio_002445 OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K08 compound treatment 178640.0 82600.0 0.7 124960.0 51600.0 0.43 0.7992 0.9715 1000064 SPBio_002446 CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K09 compound treatment 116760.0 20700.0 0.18 55120.0 -18200.0 -0.15 0.0181 0.0782 1060 SPBio_002447 CN1CCC(=C2c3ccccc3Sc4ccccc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K10 compound treatment 202320.0 106000.0 0.9 192360.0 119000.0 0.98 1.336 0.9991 3189193 SPBio_002448 CC[C@H](CO)NC(=O)[C@H]1CN(C)[C@@H]2Cc3c[nH]c4cccc(C2=C1)c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K11 compound treatment 172160.0 76100.0 0.65 148360.0 75000.0 0.62 0.8971 0.9998 1069 SPBio_002449 CCCN1C[C@H](CSC)C[C@H]2[C@H]1Cc3c[nH]c4cccc2c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K12 compound treatment 47520.0 -48500.0 -0.41 17800.0 -55500.0 -0.46 -0.6171 -0.9986 1496 SPBio_002450 CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K13 compound treatment 239480.0 143000.0 1.22 222960.0 150000.0 1.24 1.7388 1.0 1113 SPBio_002451 COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)OCC(=O)O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K14 compound treatment 97640.0 1580.0 0.01 94960.0 21600.0 0.18 0.1361 0.7581 3068886 SPBio_002452 CC(C)/N=c/1\cc2n(c3ccc(Cl)cc3)c4ccccc4nc2cc1Nc5ccc(Cl)cc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K15 compound treatment 58840.0 -37200.0 -0.32 52240.0 -21100.0 -0.17 -0.3474 -0.9604 3068682 SPBio_002453 CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K16 compound treatment 95440.0 -621.0 -0.01 71920.0 -1410.0 -0.01 -0.012 -0.9364 975 SPBio_002454 CCN(CC)CCOC(=O)C(CC1CCCO1)Cc2cccc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K17 compound treatment 82240.0 -13800.0 -0.12 82160.0 8830.0 0.07 -0.0315 -0.2276 1348 SPBio_002455 Clc1ccc(OCC(=O)N2CCN(Cc3ccc4OCOc4c3)CC2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K18 compound treatment 177600.0 81500.0 0.69 178720.0 105000.0 0.87 1.1074 0.9936 1000105 SPBio_002456 CC(C)(Oc1ccc(CCNC(=O)c2ccc(Cl)cc2)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K19 compound treatment 78440.0 -17600.0 -0.15 59880.0 -13400.0 -0.11 -0.1847 -0.9892 3055129 SPBio_002457 CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@@]21C)c5ccc(cc5)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K20 compound treatment 187560.0 91500.0 0.78 168800.0 95500.0 0.79 1.1094 1.0 1000143 SPBio_002458 NC(Cn1ccc(=O)c(O)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K21 compound treatment 131960.0 35900.0 0.31 101040.0 27700.0 0.23 0.3782 0.99 1045066 SPBio_002459 O=C(Nc1ccccc1)OCC(CN2CCCCC2)OC(=O)Nc3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K22 compound treatment 85640.0 -10400.0 -0.09 54720.0 -18600.0 -0.15 -0.1716 -0.9658 2777 SPBio_002460 COc1cc(N)c(Cl)cc1C(=O)NC2CCN(Cc3ccccc3)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K23 mock treatment 125520.0 29500.0 0.25 74120.0 794.0 0.01 0.182 0.7254 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 K24 mock treatment 44160.0 -51900.0 -0.44 31200.0 -42100.0 -0.35 -0.5589 -0.9931 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L01 mock treatment 32760.0 -63300.0 -0.54 27120.0 -46200.0 -0.38 -0.6514 -0.9858 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L02 mock treatment 87360.0 -8700.0 -0.07 64040.0 -9290.0 -0.08 -0.1067 -0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L03 compound treatment 93240.0 -2820.0 -0.02 65960.0 -7370.0 -0.06 -0.0601 -0.9172 1055159 SPBio_002461 NC(CC(=O)c1cccc(O)c1N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L04 compound treatment 68360.0 -27700.0 -0.24 52880.0 -20400.0 -0.17 -0.2864 -0.9867 907463 SPBio_002462 Cc1nc2ccccn2c(=O)c1CCN3CCC(CC3)C(=O)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L05 compound treatment 140560.0 44500.0 0.38 101720.0 28400.0 0.23 0.434 0.9736 3189433 SPBio_002463 OC[C@@H](O)[C@@H](O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)[C@H](O)[C@@H](O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L06 compound treatment 188760.0 92700.0 0.79 127320.0 54000.0 0.45 0.8739 0.9637 1024517 SPBio_002464 COc1cc2CCNC(C)c2cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L07 compound treatment 164320.0 68300.0 0.58 120720.0 47400.0 0.39 0.6882 0.9816 3069088 SPBio_002465 COC1=C[C@@H]2[C@@H](C3=C2c4c(OC)c(OC)c(OC)cc4CC[C@@H]3NC(=O)C)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L08 compound treatment 162280.0 66200.0 0.56 122080.0 48800.0 0.4 0.6839 0.9865 1193 SPBio_002466 CCOc1ccc(NC(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L09 compound treatment 135480.0 39400.0 0.34 109560.0 36200.0 0.3 0.4493 0.9984 1134 SPBio_002467 CN1C[C@H](CO)C=C2[C@H]1Cc3c[nH]c4cccc2c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L10 compound treatment 18320.0 -77700.0 -0.66 25720.0 -47600.0 -0.39 -0.7465 -0.9692 3474094 SPBio_002468 OC1=C(C2CCC(CC2)c3ccc(Cl)cc3)C(=O)c4ccccc4C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L11 compound treatment 169360.0 73300.0 0.62 135480.0 62200.0 0.51 0.8049 0.9954 3174101 SPBio_002469 CN1CCc2c(C1)c3ccccc3n2Cc4ccccc4.OS(=O)(=O)c1cccc2c(cccc12)S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L12 compound treatment 252600.0 157000.0 1.33 196200.0 123000.0 1.02 1.6612 0.9911 3058468 SPBio_002470 COc1ccc(OC)c(c1)C(O)C(C)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L13 compound treatment 214520.0 118000.0 1.01 294000.0 221000.0 1.83 2.0041 0.9609 3174345 SPBio_002471 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N.OC(=O)c1cc(ccc1O)S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L14 compound treatment 131560.0 35500.0 0.3 143400.0 70100.0 0.58 0.6236 0.9539 1001858 SPBio_002472 CC(C)NC[C@H](O)COc1ccc(CC(=O)N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L15 compound treatment 53000.0 -43100.0 -0.37 52680.0 -20600.0 -0.17 -0.38 -0.9396 1035 SPBio_002473 Cc1cccc(CN2CCN(CC2)C(c3ccccc3)c4ccc(Cl)cc4)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L16 compound treatment 117120.0 21100.0 0.18 98160.0 24800.0 0.21 0.2721 0.9977 904 SPBio_002474 NC(=O)CN1CCCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L17 compound treatment 144520.0 48500.0 0.41 107440.0 34100.0 0.28 0.4913 0.9828 988 SPBio_002475 COc1ccc2[nH]cc(CCNC(=O)C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L18 compound treatment 112120.0 16100.0 0.14 130320.0 57000.0 0.47 0.4301 0.8761 948 SPBio_002476 O=C1C(C(=O)c2ccccc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L19 compound treatment 8800.0 -87300.0 -0.74 8040.0 -65300.0 -0.54 -0.9073 -0.9877 449 SPBio_002477 CC1=CC(=O)c2ccccc2C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L20 compound treatment 137240.0 41200.0 0.35 134120.0 60800.0 0.5 0.6035 0.9844 3189446 SPBio_002478 COc1c(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc3CCC(NC(=O)C)c4cc(=O)c(SC)ccc4-c3c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L21 compound treatment 148760.0 52700.0 0.45 100680.0 27400.0 0.23 0.4773 0.9498 3069122 SPBio_002479 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@H](O)[C@@H]1C/C=C\CCCC(=O)O.COC(N)(CO)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L22 compound treatment 84320.0 -11700.0 -0.1 63080.0 -10200.0 -0.08 -0.1306 -0.9966 3068774 SPBio_002480 Nc1cc(C(=C(Cl)Cl)Cl)c(cc1S(=O)(=O)N)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L23 mock treatment 79120.0 -16900.0 -0.14 98240.0 24900.0 0.21 0.0437 0.1739 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 L24 mock treatment 48120.0 -47900.0 -0.41 33000.0 -40300.0 -0.33 -0.5245 -0.995 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M01 mock treatment 46920.0 -49100.0 -0.42 39680.0 -33600.0 -0.28 -0.4927 -0.9804 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M02 mock treatment 74240.0 -21800.0 -0.19 66600.0 -6730.0 -0.06 -0.1707 -0.8802 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M03 compound treatment 83520.0 -12500.0 -0.11 58720.0 -14600.0 -0.12 -0.1609 -0.9981 1608 SPBio_002481 NCCCC[C@H](N[C@@H](CCc1ccccc1)C(=O)O)C(=O)N2CCC[C@H]2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M04 compound treatment 8200.0 -87900.0 -0.75 6600.0 -66700.0 -0.55 -0.9193 -0.9888 907366 SPBio_002482 Cc1cccc(C)c1NC(=O)CN2CCN(CCCC(c3ccc(F)cc3)c4ccc(F)cc4)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M05 compound treatment 103080.0 7020.0 0.06 73920.0 594.0 0.0 0.0457 0.7627 3068878 SPBio_002483 CCC[C@@H]1C[C@H](N(C)C1)C(=O)N[C@H]([C@@H](C)O)[C@H]2O[C@H](SC)[C@H](O)[C@@H](O)[C@@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M06 compound treatment 99000.0 2940.0 0.03 57800.0 -15500.0 -0.13 -0.0731 -0.5588 3480396 SPBio_002484 CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M07 compound treatment 111760.0 15700.0 0.13 66640.0 -6690.0 -0.06 0.0554 0.383 907526 SPBio_002485 CN1CCN(CC(=O)N2c3c(C)scc3C(=O)Nc4ccccc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M08 compound treatment 54200.0 -41900.0 -0.36 31920.0 -41400.0 -0.34 -0.4942 -0.9998 86 SPBio_002486 COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCN(C)Cc3ccccc3)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M09 compound treatment 9920.0 -86100.0 -0.73 7920.0 -65400.0 -0.54 -0.9012 -0.9888 773 SPBio_002487 Clc1ccc(COC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M10 compound treatment 139480.0 43400.0 0.37 107560.0 34200.0 0.28 0.4617 0.9913 1210 SPBio_002488 CC(C)(C)c1cc(SC(C)(C)Sc2cc(c(O)c(c2)C(C)(C)C)C(C)(C)C)cc(c1O)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M11 compound treatment 143760.0 47700.0 0.41 115760.0 42400.0 0.35 0.5354 0.9974 1357 SPBio_002489 CCCCN1CCCCC1C(=O)Nc2c(C)cccc2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M12 compound treatment 13240.0 -82800.0 -0.71 11440.0 -61900.0 -0.51 -0.8606 -0.9876 1135 SPBio_002490 OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M13 compound treatment 95600.0 -461.0 0.0 104160.0 30800.0 0.26 0.1776 0.6961 927 SPBio_002491 CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M14 compound treatment 11120.0 -84900.0 -0.72 9040.0 -64300.0 -0.53 -0.8874 -0.9886 907273 SPBio_002492 Fc1ccc(cc1)C(OCCN2CCN(CCCc3ccccc3)CC2)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M15 compound treatment 77960.0 -18100.0 -0.15 77480.0 4150.0 0.03 -0.0847 -0.5363 876 SPBio_002493 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M16 compound treatment 45200.0 -50900.0 -0.43 51720.0 -21600.0 -0.18 -0.4326 -0.9234 990 SPBio_002494 CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M17 compound treatment 6600.0 -89500.0 -0.76 5600.0 -67700.0 -0.56 -0.9348 -0.9886 2117626 SPBio_002495 Fc1ccc(cc1)C(CCCN2CCC(CC2)n3c(=O)[nH]c4ccccc34)c5ccc(F)cc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M18 compound treatment 25040.0 -71000.0 -0.6 19840.0 -53500.0 -0.44 -0.7405 -0.9882 1351 SPBio_002496 Cc1cc(N)c2ccccc2[n+]1CCCCCCCCCC[n+]3c(C)cc(N)c4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M19 compound treatment 46000.0 -50100.0 -0.43 17800.0 -55500.0 -0.46 -0.6262 -0.9993 467359 SPBio_002497 CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M20 compound treatment 41280.0 -54800.0 -0.47 27000.0 -46300.0 -0.38 -0.6008 -0.9952 3060108 SPBio_002498 CC(=O)N1CCN(CC1)c2ccc(OC[C@H]3CO[C@@](Cn4ccnc4)(O3)c5ccc(Cl)cc5Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M21 compound treatment 64760.0 -31300.0 -0.27 67000.0 -6330.0 -0.05 -0.2255 -0.8301 714 SPBio_002499 CCN(CCCCOC(=O)c1ccc(OC)c(OC)c1)C(C)Cc2ccc(OC)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M22 compound treatment 62200.0 -33900.0 -0.29 47080.0 -26200.0 -0.22 -0.3574 -0.9902 1000211 SPBio_002500 C[C@@H]1[C@H](O)CC[C@@]2(C)[C@H]1CC[C@@]3(C)[C@H]2[C@H](O)C[C@H]4/C(=C(\CCC=C(C)C)/C(=O)O)/[C@H](C[C@@]43C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M23 mock treatment 80600.0 -15500.0 -0.13 51960.0 -21400.0 -0.18 -0.2181 -0.9895 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 M24 mock treatment 36640.0 -59400.0 -0.51 45640.0 -27700.0 -0.23 -0.5197 -0.9358 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N01 mock treatment 78480.0 -17600.0 -0.15 58480.0 -14800.0 -0.12 -0.1927 -0.9952 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N02 mock treatment 90840.0 -5220.0 -0.04 78960.0 5630.0 0.05 0.0015 0.0237 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N03 compound treatment 45040.0 -51000.0 -0.43 39360.0 -34000.0 -0.28 -0.5059 -0.9778 2830 SPBio_002501 Clc1ccc2n(C3CCN(CCCn4c(=O)[nH]c5ccccc45)CC3)c(=O)[nH]c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N04 compound treatment 5440.0 -90600.0 -0.77 4760.0 -68600.0 -0.57 -0.9467 -0.9886 1309 SPBio_002502 Cc1cc(C2CCCCC2)n(O)c(=O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N05 compound treatment 93920.0 -2140.0 -0.02 55800.0 -17500.0 -0.14 -0.1154 -0.7898 3189434 SPBio_002503 Nc1nc(cs1)/C(=N\OCC(=O)O)/C(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)C=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N06 compound treatment 98200.0 2140.0 0.02 82640.0 9310.0 0.08 0.0674 0.8508 722 SPBio_002504 CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N07 compound treatment 79840.0 -16200.0 -0.14 53680.0 -19600.0 -0.16 -0.2126 -0.9967 3069124 SPBio_002505 CN(C(=O)C)c1c(I)c(NC(=O)C)c(I)c(C(=O)NC2[C@H](O)OC(CO)[C@@H](O)[C@H]2O)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N08 compound treatment 71720.0 -24300.0 -0.21 45760.0 -27600.0 -0.23 -0.3078 -0.9989 1213 SPBio_002506 CNCCc1ccccn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N09 compound treatment 113800.0 17700.0 0.15 61880.0 -11400.0 -0.09 0.0398 0.2235 3189435 SPBio_002507 C[C@@H](O[C@@H]1[C@H](O)C(CO)O[C@H](O)C1NC(=O)C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N10 compound treatment 113360.0 17300.0 0.15 80200.0 6870.0 0.06 0.1444 0.9143 1000177 SPBio_002508 NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(N)CC1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N11 compound treatment 124600.0 28500.0 0.24 79480.0 6150.0 0.05 0.2078 0.8371 2181 SPBio_002509 Oc1cc(O)c2c(=O)c(O)c(oc2c1)c3cc(O)c(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N12 compound treatment 179080.0 83000.0 0.71 145680.0 72400.0 0.6 0.9231 0.9966 1000096 SPBio_002510 C1CN2CC(N=C2S1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N13 compound treatment 206240.0 110000.0 0.94 157840.0 84500.0 0.7 1.1577 0.9895 1733214 SPBio_002511 Oc1ccc(cc1)C2CC(=O)c3c(O)cc(O)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N14 compound treatment 57000.0 -39100.0 -0.33 41920.0 -31400.0 -0.26 -0.4189 -0.9925 3068775 SPBio_002512 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N15 compound treatment 92000.0 -4060.0 -0.03 87040.0 13700.0 0.11 0.0558 0.4702 895 SPBio_002513 C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc3cc(O)c4C(=O)C[C@H](Oc4c3)c5ccc(O)cc5)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N16 compound treatment 65600.0 -30500.0 -0.26 48640.0 -24700.0 -0.2 -0.3278 -0.993 1214 SPBio_002514 CCOC(=O)Nc1c[n+](no1)N2CCOCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N17 compound treatment 53720.0 -42300.0 -0.36 46800.0 -26500.0 -0.22 -0.4101 -0.9717 822 SPBio_002515 CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N18 compound treatment 56480.0 -39600.0 -0.34 40360.0 -33000.0 -0.27 -0.4311 -0.9945 1000114 SPBio_002516 CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N19 compound treatment 91160.0 -4900.0 -0.04 69840.0 -3490.0 -0.03 -0.0499 -0.9837 1067495 SPBio_002517 [O-][N+](=O)c1cnc(s1)N2CCNC2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N20 compound treatment 80920.0 -15100.0 -0.13 56800.0 -16500.0 -0.14 -0.1878 -0.9996 1365793 SPBio_002518 COc1ccc(CN2CCNCC2)c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N21 compound treatment 74000.0 -22100.0 -0.19 67680.0 -5650.0 -0.05 -0.1658 -0.8568 3069161 SPBio_002519 NCc1ccccc1CC(=O)N[C@H]2[C@H]3SCC(=C(N3C2=O)C(=O)O)CSc4nnnn4CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N22 compound treatment 4880.0 -91200.0 -0.78 5000.0 -68300.0 -0.57 -0.9486 -0.9878 3103826 SPBio_002520 C/C/1=C\CC[C@@]2(C)O[C@@H]2[C@H]3OC(=O)C(=C)[C@@H]3CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N23 mock treatment 78640.0 -17400.0 -0.15 83920.0 10600.0 0.09 -0.0429 -0.2491 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 N24 mock treatment 54640.0 -41400.0 -0.35 60720.0 -12600.0 -0.1 -0.3231 -0.8786 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O01 mock treatment 78840.0 -17200.0 -0.15 42920.0 -30400.0 -0.25 -0.2815 -0.967 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O02 mock treatment 78000.0 -18100.0 -0.15 43200.0 -30100.0 -0.25 -0.285 -0.9731 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O03 compound treatment 29480.0 -66600.0 -0.57 25960.0 -47400.0 -0.39 -0.6779 -0.9837 3177204 SPBio_002521 CC(C(O)c1ccc(O)cc1)N2CCC(Cc3ccccc3)CC2.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O04 compound treatment 56040.0 -40000.0 -0.34 71200.0 -2130.0 -0.02 -0.2534 -0.7426 743 SPBio_002522 CC(C)(C)NCC(O)c1cc(O)cc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O05 compound treatment 28360.0 -67700.0 -0.58 42800.0 -30500.0 -0.25 -0.5862 -0.9314 43 SPBio_002523 Fc1ccc(cc1)C(N2CCN(C/C=C/c3ccccc3)CC2)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O06 compound treatment 67840.0 -28200.0 -0.24 38960.0 -34400.0 -0.28 -0.3709 -0.9965 3061431 SPBio_002524 OC(C(O)C(=O)O)C(=O)O.Fc1ccc(cc1)C(=O)C2CCN(CCn3c(=O)[nH]c4ccccc4c3=O)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O07 compound treatment 5960.0 -90100.0 -0.77 4240.0 -69100.0 -0.57 -0.9466 -0.9895 437 SPBio_002525 CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O08 compound treatment 48880.0 -47200.0 -0.4 31840.0 -41500.0 -0.34 -0.5267 -0.9969 907335 SPBio_002526 C[N+]1(C)CCOC(O)(C1)c2ccc(cc2)c3ccc(cc3)C4(O)C[N+](C)(C)CCO4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O09 compound treatment 45160.0 -50900.0 -0.43 33960.0 -39400.0 -0.33 -0.5367 -0.9901 3189181 SPBio_002527 CCOC(=O)[C@@H](CCc1ccccc1)NC(C)C(=O)N2CCC[C@@H]2C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O10 compound treatment 60680.0 -35400.0 -0.3 43360.0 -30000.0 -0.25 -0.3883 -0.9953 3471415 SPBio_002528 NCC1OC(OC2C(N)CC(N)C(OC3OC(CO)C(O)C(N)C3O)C2O)C(O)C(O)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O11 compound treatment 95440.0 -621.0 -0.01 59200.0 -14100.0 -0.12 -0.0864 -0.7384 1077 SPBio_002529 CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O12 compound treatment 194360.0 98300.0 0.84 165560.0 92200.0 0.76 1.1314 0.9989 3068923 SPBio_002530 NCC[C@H](O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)C(O)C2O)C(O)C1OC3OC(CO)C(O)C(N)C3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O13 compound treatment 175120.0 79100.0 0.67 140840.0 67500.0 0.56 0.8709 0.9957 74 SPBio_002531 COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O14 compound treatment 91200.0 -4860.0 -0.04 66120.0 -7210.0 -0.06 -0.0714 -0.9841 3189304 SPBio_002532 COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)[C@H](O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O15 compound treatment 71000.0 -25100.0 -0.21 55840.0 -17500.0 -0.14 -0.2532 -0.9821 3055 SPBio_002533 NC(=N)NCCN1CCCCCCC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O16 compound treatment 5200.0 -90900.0 -0.77 3880.0 -69400.0 -0.57 -0.9533 -0.9893 3068926 SPBio_002534 CCN(CC)CCOc1ccc(cc1)/C(=C(/Cl)\c2ccccc2)/c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O17 compound treatment 4120.0 -91900.0 -0.78 3200.0 -70100.0 -0.58 -0.9637 -0.9891 763 SPBio_002535 CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O18 compound treatment 28160.0 -67900.0 -0.58 24040.0 -49300.0 -0.41 -0.6971 -0.9854 3189305 SPBio_002536 CN1CCCN=C1/C=C/c2cccc(O)c2.OC(=O)c1cc2ccccc2c(Cc3cc4ccccc4c(C(=O)O)c3O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O19 compound treatment 26320.0 -69700.0 -0.59 16400.0 -56900.0 -0.47 -0.7529 -0.9934 907228 SPBio_002537 CCCCCCC[N+](CC)(CC)CCCCc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O20 compound treatment 5800.0 -90300.0 -0.77 4480.0 -68800.0 -0.57 -0.9461 -0.9891 1041 SPBio_002538 CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O21 compound treatment 5360.0 -90700.0 -0.77 4440.0 -68900.0 -0.57 -0.949 -0.9888 1130 SPBio_002539 OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O22 compound treatment 87080.0 -8980.0 -0.08 66440.0 -6890.0 -0.06 -0.0944 -0.9895 3189306 SPBio_002540 COc1ccc(cc1O)[C@@H]2CC(=O)c3c(O)cc(O[C@@H]4OC(CO[C@@H]5OC(C)[C@H](O)[C@H](O)C5O)[C@@H](O)[C@@H](O)C4O)cc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O23 mock treatment 76720.0 -19300.0 -0.16 66840.0 -6490.0 -0.05 -0.1544 -0.8914 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 O24 mock treatment 43600.0 -52500.0 -0.45 52440.0 -20900.0 -0.17 -0.438 -0.9146 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P01 mock treatment 74000.0 -22100.0 -0.19 52680.0 -20600.0 -0.17 -0.2536 -0.9989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P02 mock treatment 75560.0 -20500.0 -0.17 55840.0 -17500.0 -0.14 -0.2257 -0.9956 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P03 compound treatment 10400.0 -85700.0 -0.73 7560.0 -65800.0 -0.54 -0.9004 -0.9896 1000325 SPBio_002541 C[C@@H]1O[C@@H](O[C@H]2C[C@@H](O)[C@]3(CO)[C@H]4[C@H](O)C[C@]5(C)[C@H](CC[C@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6)[C@H](O)[C@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P04 compound treatment 15160.0 -80900.0 -0.69 10760.0 -62600.0 -0.52 -0.8531 -0.9901 922 SPBio_002542 CCCCC(CC)CN1CN(CC(CC)CCCC)CC(C)(N)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P05 compound treatment 52080.0 -44000.0 -0.37 38600.0 -34700.0 -0.29 -0.4679 -0.9914 3069162 SPBio_002543 CC(C)(CO)[C@H](O)C(=O)NCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P06 compound treatment 43880.0 -52200.0 -0.44 35920.0 -37400.0 -0.31 -0.533 -0.9844 2284 SPBio_002544 C[C@H](Cc1ccccc1)N(C)CC#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P07 compound treatment 38880.0 -57200.0 -0.49 33240.0 -40100.0 -0.33 -0.5787 -0.9825 3189436 SPBio_002545 CO[C@]1(NC(=O)C2SC(=C(C(=O)N)C(=O)O)S2)[C@H]3SCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P08 compound treatment 27120.0 -68900.0 -0.59 15640.0 -57700.0 -0.48 -0.7525 -0.9947 1020 SPBio_002546 NC(=N)c1ccc(OCCCCCOc2ccc(cc2)C(=N)N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P09 compound treatment 29880.0 -66200.0 -0.56 29640.0 -43700.0 -0.36 -0.654 -0.977 1534 SPBio_002547 O=C(/C=C/C=C/c1ccc2OCOc2c1)N3CCCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P10 compound treatment 53480.0 -42600.0 -0.36 29480.0 -43800.0 -0.36 -0.5128 -1.0 196 SPBio_002548 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P11 compound treatment 58160.0 -37900.0 -0.32 44080.0 -29200.0 -0.24 -0.3993 -0.9899 1537011 SPBio_002549 CN(C)CCC(c1ccc(Br)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P12 compound treatment 54840.0 -41200.0 -0.35 52920.0 -20400.0 -0.17 -0.3675 -0.9437 1931603 SPBio_002550 Oc1ccc(cc1)C(=O)N/N=C/c2ccc(o2)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P13 compound treatment 5920.0 -90100.0 -0.77 5000.0 -68300.0 -0.57 -0.9424 -0.9887 2551 SPBio_002551 COc1cc(NC(C)CCCN)c2ncccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P14 compound treatment 63480.0 -32600.0 -0.28 65440.0 -7890.0 -0.07 -0.2423 -0.8502 804 SPBio_002552 COc1c(C)c2COC(=O)c2c(O)c1C/C=C(\C)/CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P15 compound treatment 17040.0 -79000.0 -0.67 13720.0 -59600.0 -0.49 -0.8244 -0.9883 1072 SPBio_002553 CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P16 compound treatment 43720.0 -52300.0 -0.45 47920.0 -25400.0 -0.21 -0.4637 -0.9412 3189565 SPBio_002554 CC[C@@H]1OC(=O)[C@H](C)[C@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@](C)(O)C[C@@H](C)[C@@H]4N[C@H](COCCOC)OC([C@H]4C)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P17 compound treatment 4400.0 -91700.0 -0.78 2280.0 -71000.0 -0.59 -0.9674 -0.9902 3480329 SPBio_002555 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(Cl)c2Cl)C(=O)OC)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P18 compound treatment 39080.0 -57000.0 -0.49 22720.0 -50600.0 -0.42 -0.6391 -0.9973 3474312 SPBio_002556 Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CC3CCCC3C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P19 compound treatment 47040.0 -49000.0 -0.42 49280.0 -24000.0 -0.2 -0.4358 -0.9425 1362 SPBio_002557 COc1c2occc2cc3ccc(=O)oc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P20 compound treatment 14040.0 -82000.0 -0.7 11200.0 -62100.0 -0.51 -0.8572 -0.9886 3060137 SPBio_002558 COc1ccccc1N2CCN(CCCCNC(=O)c3ccc4ccccc4c3)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P21 compound treatment 63680.0 -32400.0 -0.28 77360.0 4030.0 0.03 -0.1714 -0.617 3189437 SPBio_002559 COc1ccc(CC(N)C(=O)N[C@@H]2C(O)[C@@H](O[C@@H]2CO)n3cnc4c(ncnc34)N(C)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P22 compound treatment 3520.0 -92500.0 -0.79 4680.0 -68600.0 -0.57 -0.9587 -0.9871 1137095 SPBio_002560 CC(Cc1ccccc1)NCCC(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P23 mock treatment 74240.0 -21800.0 -0.19 63560.0 -9770.0 -0.08 -0.1885 -0.9304 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2165 P24 mock treatment 56800.0 -39300.0 -0.33 54800.0 -18500.0 -0.15 -0.3447 -0.9375 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A01 mock treatment 90800.0 -29900.0 -0.25 99640.0 -24500.0 -0.2 -0.3233 -0.9938 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A02 mock treatment 101840.0 -18800.0 -0.16 110600.0 -13600.0 -0.11 -0.1927 -0.9849 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A03 compound treatment 102880.0 -17800.0 -0.15 104800.0 -19400.0 -0.16 -0.2204 -0.9996 3189566 SPBio_002561 COc1cc2CC[N+](C)(C)[C@@H]3Cc4ccc(O)c(Oc5cc6[C@H](Cc7cccc(Oc(c1O)c32)c7)N(C)CCc6cc5OC)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A04 compound treatment 96440.0 -24200.0 -0.21 115400.0 -8780.0 -0.07 -0.1971 -0.9018 3187611 SPBio_002562 COc1cc(ccc1c2nc3ncccc3[nH]2)S(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A05 compound treatment 46280.0 -74400.0 -0.63 54240.0 -69900.0 -0.58 -0.8569 -0.999 907285 SPBio_002563 CC(C)[C@@]1(NC(=O)[C@@H]2C[C@H]3[C@@H](Cc4c[nH]c5cccc3c45)N(C)C2)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](Cc8ccccc8)N6C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A06 compound treatment 66880.0 -53800.0 -0.46 85800.0 -38400.0 -0.32 -0.5482 -0.984 1254 SPBio_002564 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A07 compound treatment 37760.0 -82900.0 -0.71 38280.0 -85900.0 -0.71 -1.0015 -1.0 961 SPBio_002565 COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5c(OC)c34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A08 compound treatment 64480.0 -56200.0 -0.48 77280.0 -46900.0 -0.39 -0.6125 -0.9946 3187612 SPBio_002566 CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A09 compound treatment 34240.0 -86400.0 -0.74 35800.0 -88400.0 -0.73 -1.0372 -1.0 3487467 SPBio_002567 CCOC(=O)Oc1c(OC)cc(cc1OC)C(=O)OC2CC3CN4CCc5c([nH]c6cc(OC)ccc56)C4CC3C(C2OC)C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A10 compound treatment 58680.0 -62000.0 -0.53 69200.0 -55000.0 -0.45 -0.6947 -0.9973 3069530 SPBio_002568 CC(=O)NC1CCSC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A11 compound treatment 76080.0 -44600.0 -0.38 78480.0 -45700.0 -0.38 -0.5357 -1.0 1000124 SPBio_002569 CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A12 compound treatment 138440.0 17800.0 0.15 149960.0 25800.0 0.21 0.2579 0.9859 1000240 SPBio_002570 CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)CC[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A13 compound treatment 107520.0 -13100.0 -0.11 102680.0 -21500.0 -0.18 -0.2048 -0.975 976 SPBio_002571 CNC(=O)Oc1ccc2N(C)[C@H]3N(C)CC[C@@]3(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A14 compound treatment 11680.0 -109000.0 -0.93 12840.0 -111000.0 -0.92 -1.3074 -1.0 3187613 SPBio_002572 C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)OC2CC[C@]3(C=O)[C@H]4CC[C@]5(C)[C@H](CC[C@@]5(O)[C@@H]4CC[C@]3(O)C2)C6=CC(=O)OC6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A15 compound treatment 63400.0 -57300.0 -0.49 74520.0 -49700.0 -0.41 -0.6352 -0.9964 3189567 SPBio_002573 CCN1C[C@@]2(COC)C3[C@@H](OC)[C@H]4[C@@H]1[C@@]3(C5C[C@@]6(O)[C@H](OC(=O)c7ccccc7)C5[C@]4(OC(=O)C)[C@@H](O)[C@H]6OC)[C@H](C[C@H]2O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A16 compound treatment 60920.0 -59700.0 -0.51 71200.0 -53000.0 -0.44 -0.6695 -0.9973 2060360 SPBio_002574 C1CN=C(C1)c2cccnc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A17 compound treatment 29360.0 -91300.0 -0.78 27920.0 -96300.0 -0.8 -1.1127 -0.9999 3141 SPBio_002575 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)/C=C/c6cc(OC)c(OC)c(OC)c6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A18 compound treatment 64240.0 -56400.0 -0.48 71440.0 -52700.0 -0.44 -0.6481 -0.9988 3069532 SPBio_002576 C[N+]1(C)C[C@@H](O)C[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A19 compound treatment 54360.0 -66300.0 -0.56 57120.0 -67100.0 -0.55 -0.7914 -1.0 3068781 SPBio_002577 CC(C)[C@@H]1N2C(=O)[C@](NC(=O)[C@@H]3C[C@H]4[C@@H](Cc5c[nH]c6cccc4c56)N(C)C3)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A20 compound treatment 79760.0 -40900.0 -0.35 88080.0 -36100.0 -0.3 -0.4574 -0.9971 946 SPBio_002578 OCCNC(=O)Cn1ccnc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A21 compound treatment 6040.0 -115000.0 -0.98 7720.0 -116000.0 -0.96 -1.3713 -1.0 3189569 SPBio_002579 CC[C@H]1CN2CCc3cc(OC)c(OC)cc3[C@@H]2C[C@@H]1CC4NCCc5cc(OC)c(OC)cc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A22 compound treatment 100800.0 -19900.0 -0.17 125200.0 1020.0 0.01 -0.1136 -0.6708 3187614 SPBio_002580 NCCC(O)C(=O)NC1CC(N)C(OC2OC(CN)C(O)[C@H](O)[C@@H]2N)[C@H](OC3O[C@H](CO)[C@@H](O)[C@@H]3O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A23 mock treatment 73600.0 -47100.0 -0.4 104080.0 -20100.0 -0.17 -0.4009 -0.9241 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 A24 mock treatment 74560.0 -46100.0 -0.39 119960.0 -4220.0 -0.03 -0.3022 -0.7669 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B01 mock treatment 124680.0 4020.0 0.03 135400.0 11200.0 0.09 0.0899 0.9082 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B02 mock treatment 105000.0 -15700.0 -0.13 99840.0 -24300.0 -0.2 -0.2366 -0.98 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B03 compound treatment 96080.0 -24600.0 -0.21 116200.0 -7980.0 -0.07 -0.1946 -0.887 1606 SPBio_002581 NS(=O)(=O)c1cc2c(NC(CSCC=C)NS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B04 compound treatment 73240.0 -47400.0 -0.4 74760.0 -49400.0 -0.41 -0.5745 -1.0 1412 SPBio_002582 CN(C)CCOC(c1ccc(Cl)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B05 compound treatment 102120.0 -18500.0 -0.16 102520.0 -21700.0 -0.18 -0.2383 -0.998 1524 SPBio_002583 CC(C)Nc1c(C)n(C)n(c2ccccc2)c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B06 compound treatment 82480.0 -38200.0 -0.33 92480.0 -31700.0 -0.26 -0.4153 -0.9943 3069629 SPBio_002584 CC(=O)/N=c/1\sc(nn1C)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B07 compound treatment 60000.0 -60700.0 -0.52 68840.0 -55300.0 -0.46 -0.6889 -0.9982 883 SPBio_002585 CC(Oc1ccccc1)C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B08 compound treatment 50240.0 -70400.0 -0.6 60560.0 -63600.0 -0.53 -0.7961 -0.9979 818 SPBio_002586 CCC1(CC)C(=O)NC=CC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B09 compound treatment 41200.0 -79500.0 -0.68 59640.0 -64500.0 -0.53 -0.8559 -0.9931 887 SPBio_002587 COc1ccc(NS(=O)(=O)c2ccc(N)cc2)nn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B10 compound treatment 62040.0 -58600.0 -0.5 69760.0 -54400.0 -0.45 -0.6712 -0.9987 795 SPBio_002588 CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B11 compound treatment 97520.0 -23100.0 -0.2 107800.0 -16400.0 -0.14 -0.2351 -0.9833 745 SPBio_002589 CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B12 compound treatment 173360.0 52700.0 0.45 180920.0 56700.0 0.47 0.6492 0.9997 1129 SPBio_002590 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B13 compound treatment 175960.0 55300.0 0.47 175240.0 51100.0 0.42 0.6317 0.9985 3263 SPBio_002591 CNC(C)(C)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B14 compound treatment 73080.0 -47600.0 -0.41 82520.0 -41700.0 -0.34 -0.5301 -0.9968 755 SPBio_002592 CC(CN(C)C)CN1c2ccccc2CCc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B15 compound treatment 65520.0 -55100.0 -0.47 66760.0 -57400.0 -0.47 -0.6678 -1.0 3187750 SPBio_002593 CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@@H]4Cc5c[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B16 compound treatment 47640.0 -73000.0 -0.62 65160.0 -59000.0 -0.49 -0.7848 -0.9928 1088922 SPBio_002594 CN(C)CCN(Cc1ccc(Cl)cc1)c2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B17 compound treatment 39520.0 -81100.0 -0.69 61280.0 -62900.0 -0.52 -0.8564 -0.9902 751 SPBio_002595 COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B18 compound treatment 38880.0 -81800.0 -0.7 56000.0 -68200.0 -0.56 -0.8911 -0.9945 3043753 SPBio_002596 [O-][N+](=O)c1ccc(/C=N/N2CCOC2=O)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B19 compound treatment 75560.0 -45100.0 -0.38 99280.0 -24900.0 -0.21 -0.4171 -0.9574 1146 SPBio_002597 Nc1ccc(cc1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B20 compound treatment 99360.0 -21300.0 -0.18 105360.0 -18800.0 -0.16 -0.2383 -0.9971 2570 SPBio_002598 NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B21 compound treatment 85760.0 -34900.0 -0.3 88600.0 -35600.0 -0.29 -0.4182 -1.0 3069577 SPBio_002599 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC(=O)[C@]23C)OC61CCC(C)CO6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B22 compound treatment 6640.0 -114000.0 -0.97 6920.0 -117000.0 -0.97 -1.3723 -1.0 871 SPBio_002600 Clc1ccc(CSC(Cn2ccnc2)c3ccc(Cl)cc3Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B23 mock treatment 116000.0 -4660.0 -0.04 116960.0 -7220.0 -0.06 -0.0702 -0.9802 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 B24 mock treatment 94400.0 -26300.0 -0.22 126720.0 2540.0 0.02 -0.1432 -0.6377 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C01 mock treatment 99160.0 -21500.0 -0.18 96600.0 -27600.0 -0.23 -0.2907 -0.994 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C02 mock treatment 111480.0 -9180.0 -0.08 112160.0 -12000.0 -0.1 -0.1255 -0.9929 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C03 compound treatment 47120.0 -73500.0 -0.63 49200.0 -75000.0 -0.62 -0.8813 -1.0 1218 SPBio_002601 CCCCNc1ccc(cc1)C(=O)OCCN(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C04 compound treatment 96920.0 -23700.0 -0.2 119640.0 -4540.0 -0.04 -0.1694 -0.8243 1624 SPBio_002602 CCC1=C(C)CN(C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)N[C@H]3CC[C@H](C)CC3)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C05 compound treatment 50880.0 -69800.0 -0.59 51520.0 -72700.0 -0.6 -0.8451 -1.0 1000293 SPBio_002603 C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C06 compound treatment 134000.0 13300.0 0.11 136000.0 11800.0 0.1 0.1495 0.9972 3187615 SPBio_002604 CC(=C)[C@@H]1[C@H]2OC(=O)[C@@H]1[C@]3(O)C[C@H]4O[C@]45C(=O)OC2[C@@]53C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C07 compound treatment 62160.0 -58500.0 -0.5 52760.0 -71400.0 -0.59 -0.7699 -0.9964 3189571 SPBio_002605 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]61CCC(C)CN6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C08 compound treatment 77360.0 -43300.0 -0.37 80200.0 -44000.0 -0.36 -0.5179 -1.0 1244 SPBio_002606 C[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C09 compound treatment 64640.0 -56000.0 -0.48 79080.0 -45100.0 -0.37 -0.601 -0.9926 964 SPBio_002607 CN(C)N=Nc1[nH]cnc1C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C10 compound treatment 80920.0 -39700.0 -0.34 85440.0 -38700.0 -0.32 -0.4658 -0.9996 3187616 SPBio_002608 C/C(=C(\CCOP(=O)(O)O)/SC(=O)c1ccccc1)/N(Cc2cnc(C)nc2N)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C11 compound treatment 114400.0 -6260.0 -0.05 120320.0 -3860.0 -0.03 -0.0602 -0.9699 3471597 SPBio_002609 CC(C)[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C12 compound treatment 193360.0 72700.0 0.62 171000.0 46800.0 0.39 0.7116 0.9745 3069534 SPBio_002610 CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)CC[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C13 compound treatment 163720.0 43100.0 0.37 135000.0 10800.0 0.09 0.3226 0.8547 1092107 SPBio_002611 CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C14 compound treatment 30600.0 -90100.0 -0.77 24480.0 -99700.0 -0.82 -1.1254 -0.9993 3187617 SPBio_002612 CC1OC(C[C@@H](O)[C@@H]1OC2C[C@@H](O)[C@H](OC3C[C@@H](OC(=O)C)[C@H](OC4OC(CO)[C@@H](O)[C@@H](O)[C@@H]4O)C(C)O3)C(C)O2)OC5CC[C@@]6(C)[C@H](CC[C@@]7(C)[C@@]8(O)CC[C@H](C9=CC(=O)OC9)[C@@]8(C)[C@H](O)C[C@]67C)C5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C15 compound treatment 76560.0 -44100.0 -0.38 77240.0 -46900.0 -0.39 -0.54 -0.9999 1000115 SPBio_002613 COC(=O)[C@@H]1[C@@H](O)CC[C@@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C16 compound treatment 54400.0 -66300.0 -0.56 61560.0 -62600.0 -0.52 -0.7652 -0.9991 3103678 SPBio_002614 N/C(=N\C(=O)c1nc(Cl)c(N)nc1N)/NCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C17 compound treatment 60920.0 -59700.0 -0.51 62280.0 -61900.0 -0.51 -0.7217 -1.0 450 SPBio_002615 COC(=O)[C@@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C18 compound treatment 69160.0 -51500.0 -0.44 71520.0 -52700.0 -0.44 -0.6181 -1.0 827 SPBio_002616 CCCCC1(COC(=O)CCC(=O)O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C19 compound treatment 97600.0 -23100.0 -0.2 93120.0 -31100.0 -0.26 -0.3205 -0.9912 1084508 SPBio_002617 COc1ccc2cc3-c4cc(OC)c(OC)cc4CC[n+]3cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C20 compound treatment 102720.0 -17900.0 -0.15 97000.0 -27200.0 -0.22 -0.267 -0.9822 3069535 SPBio_002618 C(Nc1ncnc2nc[nH]c12)c3ccco3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C21 compound treatment 131160.0 10500.0 0.09 100440.0 -23700.0 -0.2 -0.0756 -0.3504 1219467 SPBio_002619 COc1cc2CCC(N)c3cc(=O)c(O)ccc3-c2c(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C22 compound treatment 46280.0 -74400.0 -0.63 34400.0 -89800.0 -0.74 -0.9729 -0.9969 3187618 SPBio_002620 CC[C@H](C)[C@H]1O[C@@]2(C[C@@H]3C[C@@H](C/C=C(\C)/C(O[C@H]4C[C@H](OC)C(O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)/C=C/C=C/6\CO[C@@H]7[C@H](O)C(=C[C@@H](C(=O)O3)[C@@]76O)C)O2)C=C[C@@H]1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C23 mock treatment 101120.0 -19500.0 -0.17 106920.0 -17300.0 -0.14 -0.2186 -0.9971 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 C24 mock treatment 105320.0 -15300.0 -0.13 129120.0 4940.0 0.04 -0.0634 -0.4634 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D01 mock treatment 74240.0 -46400.0 -0.4 77800.0 -46400.0 -0.38 -0.5507 -0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D02 mock treatment 72040.0 -48600.0 -0.41 80160.0 -44000.0 -0.36 -0.5502 -0.998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D03 compound treatment 85000.0 -35700.0 -0.3 94760.0 -29400.0 -0.24 -0.3867 -0.994 706 SPBio_002621 Nc1ccc(cc1)S(=O)(=O)Nc2cnc3ccccc3n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D04 compound treatment 121880.0 1220.0 0.01 109520.0 -14700.0 -0.12 -0.0784 -0.644 3472295 SPBio_002622 COc1c(O)cc2C(=O)OC3C(O)C(O)C(CO)OC3c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D05 compound treatment 141880.0 21200.0 0.18 166920.0 42700.0 0.35 0.3778 0.9514 3187751 SPBio_002623 CN(N=O)C(=O)NC1[C@@H](O)OC(CO)[C@@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D06 compound treatment 153600.0 32900.0 0.28 182680.0 58500.0 0.48 0.5406 0.9664 1446 SPBio_002624 OC(COc1cccc2oc(cc(=O)c12)C(=O)O)COc3cccc4oc(cc(=O)c34)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D07 compound treatment 91480.0 -29200.0 -0.25 90880.0 -33300.0 -0.28 -0.3704 -0.9987 3173081 SPBio_002625 COCCc1ccc(OCC(O)CNC(C)C)cc1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D08 compound treatment 109720.0 -10900.0 -0.09 114520.0 -9660.0 -0.08 -0.1223 -0.9971 3187884 SPBio_002626 CCCC(=O)Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(=O)(O)O[C@@H]4C3OC(=O)CCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D09 compound treatment 97440.0 -23200.0 -0.2 123560.0 -616.0 -0.01 -0.1434 -0.7251 3187752 SPBio_002627 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D10 compound treatment 96680.0 -24000.0 -0.2 98320.0 -25900.0 -0.21 -0.2956 -0.9997 3176931 SPBio_002628 NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@@H](c4ccccc4)S(=O)(=O)O)C3=O)C(=O)O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D11 compound treatment 129400.0 8740.0 0.07 163480.0 39300.0 0.33 0.2826 0.8471 359 SPBio_002629 FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC2CCCCN2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D12 compound treatment 214640.0 94000.0 0.8 221560.0 97400.0 0.81 1.1355 1.0 717 SPBio_002630 OC(=O)c1ccccc1OP(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D13 compound treatment 212040.0 91400.0 0.78 220280.0 96100.0 0.8 1.1124 0.9999 689 SPBio_002631 Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn4cnnn4)C3=O)C(=O)O)s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D14 compound treatment 130360.0 9700.0 0.08 149400.0 25200.0 0.21 0.206 0.9178 1102 SPBio_002632 CC(C(=O)O)c1ccc(cc1)C(=O)c2cccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D15 compound treatment 111560.0 -9100.0 -0.08 129040.0 4860.0 0.04 -0.0263 -0.3015 3173859 SPBio_002633 CC(C)CC(=O)OC1C(O[C@@H]2C[C@H]([C@H]3CC[C@]4(CC5CC[C@H]4[C@]3(C)C2)[C@@H](O)C5=C)C(=O)O)OC(CO)C(OS(=O)(=O)O)C1OS(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D16 compound treatment 111520.0 -9140.0 -0.08 131240.0 7060.0 0.06 -0.0137 -0.1406 1254 SPBio_002634 O[C@H]1Cc2c(O)cc(O)cc2O[C@@H]1c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D17 compound treatment 86960.0 -33700.0 -0.29 95640.0 -28500.0 -0.24 -0.3698 -0.9953 873 SPBio_002635 Nc1nc(=O)c2N(C=O)C(CNc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)CNc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D18 compound treatment 93080.0 -27600.0 -0.23 121120.0 -3060.0 -0.03 -0.1839 -0.7787 1055 SPBio_002636 CC(C)(C)NCC(O)COc1cccc2C[C@@H](O)[C@@H](O)Cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D19 compound treatment 86960.0 -33700.0 -0.29 88160.0 -36000.0 -0.3 -0.4136 -0.9998 1402956 SPBio_002637 CC(N)C(O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D20 compound treatment 124240.0 3580.0 0.03 123280.0 -896.0 -0.01 0.0163 0.5202 1000139 SPBio_002638 CO[C@]1(NC(=O)C(C(=O)O)c2ccc(O)cc2)[C@H]3OCC(=C(N3C1=O)C(=O)O)CSc4nnnn4C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D21 compound treatment 14640.0 -106000.0 -0.9 10240.0 -114000.0 -0.94 -1.3048 -0.9998 1531 SPBio_002639 O=c1n([se]c2ccccc12)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D22 compound treatment 90200.0 -30500.0 -0.26 89720.0 -34500.0 -0.29 -0.3849 -0.9989 856 SPBio_002640 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D23 mock treatment 90320.0 -30300.0 -0.26 97680.0 -26500.0 -0.22 -0.3376 -0.9967 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 D24 mock treatment 72160.0 -48500.0 -0.41 67280.0 -56900.0 -0.47 -0.6248 -0.9979 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E01 mock treatment 62920.0 -57700.0 -0.49 54800.0 -69400.0 -0.57 -0.7534 -0.997 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E02 mock treatment 57440.0 -63200.0 -0.54 58200.0 -66000.0 -0.55 -0.7665 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E03 compound treatment 113240.0 -7420.0 -0.06 117480.0 -6700.0 -0.06 -0.0838 -0.9979 3180327 SPBio_002641 COc1ccc2[C@H](OC(=O)c2c1OC)[C@@H]3N(C)CCc4cc5OCOc5cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E04 compound treatment 157880.0 37200.0 0.32 178520.0 54300.0 0.45 0.542 0.9854 3069536 SPBio_002642 OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c2c(O)cc(O)c3c(=O)cc(oc23)c4ccc(O)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E05 compound treatment 153240.0 32600.0 0.28 170240.0 46100.0 0.38 0.4656 0.9878 1054667 SPBio_002643 CN1C(CC(O)c2ccccc2)CCCC1CC(O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E06 compound treatment 155000.0 34300.0 0.29 185120.0 60900.0 0.5 0.5633 0.9664 1001945 SPBio_002644 CN1C[C@@]2(C=C)C3CC4OCC3C1[C@@H]2[C@@]45C(=O)Nc6ccccc65 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E07 compound treatment 102640.0 -18000.0 -0.15 105520.0 -18700.0 -0.15 -0.2176 -1.0 959 SPBio_002645 COc1ccc(Cc2nccc3cc(OC)c(OC)cc23)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E08 compound treatment 122760.0 2100.0 0.02 122520.0 -1660.0 -0.01 0.003 0.132 3187619 SPBio_002646 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)OC61CCC(C)CN6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E09 compound treatment 137440.0 16800.0 0.14 162200.0 38000.0 0.31 0.3235 0.9363 3000363 SPBio_002647 COC(=O)[C@H]1[C@@H](O)CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E10 compound treatment 135800.0 15100.0 0.13 160480.0 36300.0 0.3 0.3035 0.9287 3069538 SPBio_002648 CCN1C[C@]2(COC)CC[C@H](OC)[C@]3(C4C[C@H]5[C@H](OC)C4C6(C[C@@H]5OC)OCO[C@@]76[C@@H](O)C32)[C@@H]17 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E11 compound treatment 167600.0 46900.0 0.4 169080.0 44900.0 0.37 0.5453 0.9993 3061052 SPBio_002649 CN1[C@H](C[C@H](O)c2ccccc2)CCC[C@@H]1CC(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E12 compound treatment 210480.0 89800.0 0.76 258840.0 135000.0 1.11 1.3285 0.9832 1054504 SPBio_002650 COc1c(OCC(O)C(C)(C)O)ccc2c(OC)c3ccoc3nc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E13 compound treatment 181520.0 60900.0 0.52 179920.0 55700.0 0.46 0.6925 0.9983 909 SPBio_002651 COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E14 compound treatment 179560.0 58900.0 0.5 237480.0 113000.0 0.94 1.0174 0.9571 3187620 SPBio_002652 C[C@H]1CCC[C@@H](C)N1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E15 compound treatment 114480.0 -6180.0 -0.05 126000.0 1820.0 0.02 -0.0265 -0.4847 3189572 SPBio_002653 CN1Cc2c3OCOc3ccc2[C@H]4[C@@H](O)Cc5cc6OCOc6cc5[C@H]41 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E16 compound treatment 147680.0 27000.0 0.23 155960.0 31800.0 0.26 0.3486 0.9978 1540789 SPBio_002654 COc1cc(=O)n(C)c2c(OCC(O)C(C)(C)O)cccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E17 compound treatment 158320.0 37700.0 0.32 150400.0 26200.0 0.22 0.3802 0.9819 1202 SPBio_002655 COc1ccc2CN(C)CC[C@]34C=C[C@H](O)C[C@@H]4Oc1c23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E18 compound treatment 119480.0 -1180.0 -0.01 140960.0 16800.0 0.14 0.0911 0.6544 1054505 SPBio_002656 COc1ccc2c(OC)c3ccoc3nc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E19 compound treatment 156760.0 36100.0 0.31 176080.0 51900.0 0.43 0.521 0.9866 1220 SPBio_002657 CN1CCc2cc3OCOc3cc2[C@H]1[C@@H]4OC(=O)c5c6OCOc6ccc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E20 compound treatment 146600.0 25900.0 0.22 178960.0 54800.0 0.45 0.4767 0.9454 852250 SPBio_002658 C1CCC(NC1)c2cccnc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E21 compound treatment 141400.0 20700.0 0.18 141600.0 17400.0 0.14 0.2268 0.9949 3173993 SPBio_002659 O[C@H]1CC[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E22 compound treatment 71720.0 -48900.0 -0.42 78320.0 -45900.0 -0.38 -0.5629 -0.9989 193 SPBio_002660 COc1cc2CCN(C)[C@H]3Cc4ccc(OC)c(Oc5ccc(C[C@@H]6N(C)CCc7cc(OC)c(Oc(c1OC)c32)cc67)cc5)c4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E23 mock treatment 148040.0 27400.0 0.23 134280.0 10100.0 0.08 0.224 0.9043 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 E24 mock treatment 71520.0 -49100.0 -0.42 77520.0 -46700.0 -0.39 -0.5688 -0.9992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F01 mock treatment 68360.0 -52300.0 -0.45 42480.0 -81700.0 -0.68 -0.7927 -0.9795 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F02 mock treatment 52800.0 -67900.0 -0.58 71640.0 -52500.0 -0.43 -0.7159 -0.9902 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F03 compound treatment 83080.0 -37600.0 -0.32 119800.0 -4380.0 -0.04 -0.2518 -0.7821 3069579 SPBio_002661 NC(=O)c1ccc[n+](c1)[C@H]2O[C@@H](COP(=O)(O)OP(=O)(O)OC[C@H]3O[C@H](C(O)[C@H]3O)n4cnc5c(N)ncnc45)C(O)[C@H]2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F04 compound treatment 154880.0 34200.0 0.29 147600.0 23400.0 0.19 0.3431 0.9804 691 SPBio_002662 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](NC(=O)N3CCNC3=O)c4ccccc4)C(=O)N2C1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F05 compound treatment 200320.0 79700.0 0.68 199720.0 75500.0 0.62 0.9215 0.9992 799 SPBio_002663 Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F06 compound treatment 187000.0 66300.0 0.56 205840.0 81700.0 0.68 0.8771 0.996 1303 SPBio_002664 C[N+]1(CCC2CC1)CC2OC(=O)C(O)(c3ccccc3)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F07 compound treatment 129800.0 9140.0 0.08 134360.0 10200.0 0.08 0.1146 0.9992 3187753 SPBio_002665 C[C@H]1C[C@H]2[C@@H]3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)CCC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F08 compound treatment 183000.0 62300.0 0.53 171280.0 47100.0 0.39 0.6509 0.9884 1529 SPBio_002666 COc1cc(NS(=O)(=O)c2ccc(N)cc2)ncn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F09 compound treatment 126640.0 5980.0 0.05 156040.0 31900.0 0.26 0.2224 0.8284 3187754 SPBio_002667 CNCC(O)C(O)C(O)C(O)CO.Cc1c(Nc2ncccc2C(=O)O)cccc1C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F10 compound treatment 196800.0 76100.0 0.65 207440.0 83300.0 0.69 0.9455 0.9995 1114 SPBio_002668 NS(=O)(=O)c1cc2c(N=C(CSCc3ccccc3)NS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F11 compound treatment 214720.0 94100.0 0.8 233520.0 109000.0 0.9 1.2059 0.9982 3187755 SPBio_002669 CO[C@H]1[C@H](O)CC(=O)O[C@H](C)C/C=C/C=C/[C@H](OC2CCC(C(C)O2)N(C)C)[C@H](C)C[C@H](CC=O)[C@@H]1OC3OC(C)C(OC4CC(C)(O)C(O)C(C)O4)C(C3O)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F12 compound treatment 230200.0 110000.0 0.93 240720.0 117000.0 0.96 1.3413 0.9999 1000 SPBio_002670 NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F13 compound treatment 237240.0 117000.0 0.99 270080.0 146000.0 1.21 1.5554 0.9953 3069580 SPBio_002671 C[N+]1(C)CCC(C1)OC(=O)C(O)(C2CCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F14 compound treatment 164840.0 44200.0 0.38 167400.0 43200.0 0.36 0.5189 0.9997 1052436 SPBio_002672 CCN(CC)CCc1nc(no1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F15 compound treatment 173440.0 52800.0 0.45 191200.0 67000.0 0.55 0.7099 0.9946 3069581 SPBio_002673 Cn1nnnc1SCC2=C(N3[C@H](SC2)[C@H](NC(=O)[C@H](O)c4ccccc4)C3=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F16 compound treatment 181080.0 60400.0 0.51 197760.0 73600.0 0.61 0.7942 0.9965 1397 SPBio_002674 CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F17 compound treatment 120480.0 -176.0 0.0 102000.0 -22200.0 -0.18 -0.1308 -0.7129 3187756 SPBio_002675 CC[C@]1(CC[C@@H](O1)[C@]2(C)CC[C@]3(C[C@H](O)[C@@H](C)[C@H](O3)[C@@H](C)[C@@H](OC)C(C)C(=O)O)O2)[C@@H]4O[C@H](C[C@@H]4C)[C@H]5O[C@@](O)(CO)[C@H](C)C[C@@H]5C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F18 compound treatment 12920.0 -108000.0 -0.92 14680.0 -109000.0 -0.91 -1.2891 -1.0 3187885 SPBio_002676 CC[C@H]([C@H]1O[C@@](CC)(C[C@@H]1C)[C@H]2CC[C@](O)(CC)[C@H](C)O2)C(=O)[C@@H](C)[C@@H](O)[C@H](C)CCc3ccc(C)c(O)c3C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F19 compound treatment 156240.0 35600.0 0.3 203280.0 79100.0 0.65 0.677 0.9388 4338 SPBio_002677 CCC(NC(C)C)C(O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F20 compound treatment 173880.0 53200.0 0.45 176040.0 51900.0 0.43 0.6238 0.9996 1519 SPBio_002678 CC1(C)OC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F21 compound treatment 176240.0 55600.0 0.47 185680.0 61500.0 0.51 0.6944 0.9993 3069582 SPBio_002679 C[C@@]1(O)CCOC(=O)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F22 compound treatment 124320.0 3660.0 0.03 148160.0 24000.0 0.2 0.1624 0.8083 852 SPBio_002680 CCOc1ccc(Cc2nccc3cc(OCC)c(OCC)cc23)cc1OCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F23 mock treatment 165200.0 44500.0 0.38 123800.0 -376.0 0.0 0.266 0.7013 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 F24 mock treatment 58000.0 -62700.0 -0.53 74880.0 -49300.0 -0.41 -0.6656 -0.9912 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G01 mock treatment 117320.0 -3340.0 -0.03 78680.0 -45500.0 -0.38 -0.2862 -0.7583 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G02 mock treatment 62200.0 -58500.0 -0.5 56680.0 -67500.0 -0.56 -0.7468 -0.9984 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G03 compound treatment 106320.0 -14300.0 -0.12 107040.0 -17100.0 -0.14 -0.1866 -0.9972 1000946 SPBio_002681 COc1ccc(CC2N(C)CCc3cc(OC)c(OC)cc23)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G04 compound treatment 68520.0 -52100.0 -0.44 78240.0 -45900.0 -0.38 -0.5826 -0.997 3129 SPBio_002682 CC(=O)[C@H]1CC[C@H]2[C@@H]3C=CC4=CC(=O)CC[C@@]4(C)[C@@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G05 compound treatment 174200.0 53500.0 0.46 194520.0 70300.0 0.58 0.7338 0.9927 3054974 SPBio_002683 COC(=O)C1=CO[C@@H](C)[C@H]2CN3CCc4c([nH]c5ccccc45)[C@@H]3C[C@@H]21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G06 compound treatment 201040.0 80400.0 0.68 222200.0 98000.0 0.81 1.0574 0.9964 1025381 SPBio_002684 COc1ccc2CC3N(CCc4cc5OCOc5cc34)Cc2c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G07 compound treatment 151680.0 31000.0 0.26 173840.0 49700.0 0.41 0.4773 0.9772 3189573 SPBio_002685 COC(=O)C1=CO[C@@H](C)[C@@H]2CN3CCc4c([nH]c5ccccc45)C3C[C@@H]21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G08 compound treatment 199000.0 78300.0 0.67 203680.0 79500.0 0.66 0.9367 1.0 3187622 SPBio_002686 CCN1C[C@]2(C)CC[C@H](OC)[C@@]34C2[C@H](OC(=O)C)C5(OCO[C@]65C[C@H](OC)C7C[C@]4(O)C6[C@H]7OC)[C@@H]13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G09 compound treatment 194840.0 74200.0 0.63 182720.0 58500.0 0.48 0.7891 0.9914 915 SPBio_002687 OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G10 compound treatment 204840.0 84200.0 0.72 204320.0 80100.0 0.66 0.9756 0.9992 1182082 SPBio_002688 Cn1c(cc(=O)c2ccccc12)c3ccc4OCOc4c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G11 compound treatment 244120.0 123000.0 1.05 227000.0 103000.0 0.85 1.3448 0.9945 1056553 SPBio_002689 CN1CCC23C4Nc5ccccc5C3(CCN4C)C1Nc6ccccc62 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G12 compound treatment 237120.0 116000.0 0.99 226400.0 102000.0 0.85 1.2991 0.9969 3069539 SPBio_002690 CN1CCC2=C[C@@H](O)[C@@H]3OC(=O)c4cc5OCOc5cc4C3[C@@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G13 compound treatment 144400.0 23700.0 0.2 138920.0 14700.0 0.12 0.2292 0.9707 3069519 SPBio_002691 COc1ccc(cc1OC)C(=O)O[C@@H]2C[C@@H]3CC[C@H](C2)N3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G14 compound treatment 19560.0 -101000.0 -0.86 18600.0 -106000.0 -0.87 -1.2262 -1.0 3187623 SPBio_002692 CC=C(C)C(=O)OC1[C@H](OC(=O)C)C2(CO)[C@H](O)C[C@]3(C)C(=CCC4C5(C)CCC(OC6OC([C@H](O[C@H]7OC(CO)[C@H](O)[C@H](O)C7O)[C@H](O)C6O[C@H]8OC(CO)[C@H](O)[C@H](O)C8O)C(=O)O)[C@](C)(CO)C5CCC43C)C2CC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G15 compound treatment 201280.0 80600.0 0.69 196040.0 71900.0 0.59 0.9058 0.9974 2060325 SPBio_002693 COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(c34)-c2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G16 compound treatment 15400.0 -105000.0 -0.9 16120.0 -108000.0 -0.89 -1.2658 -1.0 829 SPBio_002694 CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G17 compound treatment 162040.0 41400.0 0.35 176760.0 52600.0 0.44 0.5568 0.9945 1076 SPBio_002695 Cc1cccc(C)c1NC2=NCCCS2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G18 compound treatment 205760.0 85100.0 0.72 195640.0 71500.0 0.59 0.9304 0.9949 1115322 SPBio_002696 COc1ccn(C)c(=O)c1C#N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G19 compound treatment 199680.0 79000.0 0.67 200720.0 76500.0 0.63 0.9235 0.9995 3179848 SPBio_002697 C/C=C\1/CC(=C)[C@@](C)(O)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G20 compound treatment 200880.0 80200.0 0.68 203280.0 79100.0 0.65 0.9457 0.9998 3069540 SPBio_002698 CCN1C[C@]2(COC)CC[C@H](O)[C@]3(C4C[C@H]5C(OC)C4[C@](O)(C[C@H]5OC)C6(O)C(OC)C32)[C@H]16 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G21 compound treatment 115320.0 -5340.0 -0.05 129840.0 5660.0 0.05 0.001 0.0154 1737132 SPBio_002699 COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c2c34)cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G22 compound treatment 157960.0 37300.0 0.32 175400.0 51200.0 0.42 0.5242 0.9899 3187624 SPBio_002700 C/C=C\1/C[N@@+]2(C)CCC34[C@@H]2C[C@@H]1C(=C4Nc5ccccc53)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G23 mock treatment 148000.0 27300.0 0.23 152320.0 28100.0 0.23 0.3293 1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 G24 mock treatment 72640.0 -48000.0 -0.41 86360.0 -37800.0 -0.31 -0.5103 -0.9913 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H01 mock treatment 135640.0 15000.0 0.13 96400.0 -27800.0 -0.23 -0.0723 -0.275 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H02 mock treatment 85200.0 -35500.0 -0.3 100040.0 -24100.0 -0.2 -0.3547 -0.9799 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H03 compound treatment 108640.0 -12000.0 -0.1 110400.0 -13800.0 -0.11 -0.1529 -0.9986 3480633 SPBio_002701 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4CCCO4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H04 compound treatment 74280.0 -46400.0 -0.39 73520.0 -50700.0 -0.42 -0.5755 -0.9996 1452 SPBio_002702 CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H05 compound treatment 155400.0 34700.0 0.3 160920.0 36700.0 0.3 0.4241 0.9999 1404 SPBio_002703 Nc1ccc(N=Nc2ccccc2)c(N)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H06 compound treatment 207960.0 87300.0 0.74 210960.0 86800.0 0.72 1.0333 0.9998 1189 SPBio_002704 CO[C@]1(NC(=O)Cc2cccs2)[C@H]3SCC(=C(N3C1=O)C(=O)O)COC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H07 compound treatment 214000.0 93300.0 0.79 209720.0 85500.0 0.71 1.0624 0.9983 1451 SPBio_002705 CN(C)[C@H]1[C@@H]2C[C@@H]3[C@H](O)c4c(Cl)ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H08 compound treatment 217920.0 97300.0 0.83 216920.0 92700.0 0.77 1.1281 0.9993 1000080 SPBio_002706 ClCCNP1(=O)OCCCN1CCCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H09 compound treatment 212360.0 91700.0 0.78 236040.0 112000.0 0.93 1.2065 0.9964 1438 SPBio_002707 CC(C(=O)O)c1cccc(Oc2ccccc2)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H10 compound treatment 218000.0 97300.0 0.83 238320.0 114000.0 0.94 1.2538 0.9979 3187886 SPBio_002708 CO[C@@H]1[C@H](OC(=O)N)C(O)[C@H](Oc2ccc3c(O)c(NC(=O)c4ccc(O)c(CC=C(C)C)c4)c(=O)oc3c2C)OC1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H11 compound treatment 273200.0 153000.0 1.3 257480.0 133000.0 1.1 1.6982 0.9967 963 SPBio_002709 CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SC(C)(C)[C@@H](N3C2=O)C(=O)O)c4ccccc4)C(=O)C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H12 compound treatment 271440.0 151000.0 1.28 253000.0 129000.0 1.07 1.6614 0.9957 1232 SPBio_002710 OC1=C(O)C(=O)C(=C(O)C1=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H13 compound treatment 51280.0 -69400.0 -0.59 45040.0 -79100.0 -0.65 -0.8806 -0.9987 1138 SPBio_002711 CC/C(=C(/CC)\c1ccc(O)cc1)/c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H14 compound treatment 192960.0 72300.0 0.62 193560.0 69400.0 0.57 0.8412 0.9994 1029 SPBio_002712 CC(C(=O)O)c1ccc(cc1)N2Cc3ccccc3C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H15 compound treatment 181640.0 61000.0 0.52 218640.0 94500.0 0.78 0.9197 0.9803 3057880 SPBio_002713 COc1ccc(cc1)C(=C(c2ccc(OC)cc2)c3ccc(OC)cc3)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H16 compound treatment 157560.0 36900.0 0.31 172000.0 47800.0 0.4 0.5019 0.9935 1276 SPBio_002714 CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]3(C)[C@@H]2C(=O)C=C4[C@@H]5C[C@](C)(CC[C@]5(C)CC[C@]43C)C(=O)O)OC(=O)CCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H17 compound treatment 193040.0 72400.0 0.62 236920.0 113000.0 0.93 1.0953 0.9798 3187757 SPBio_002715 NCC1OC(OC2C(N)CC(N)C(O)C2O[C@@H]3O[C@H](CO)[C@H](O)C3O)C(N)C(O)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H18 compound treatment 221320.0 101000.0 0.86 221880.0 97700.0 0.81 1.1776 0.9996 3187887 SPBio_002716 CC(CN(C(=O)C)c1c(I)cc(I)c(N)c1I)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H19 compound treatment 220000.0 99300.0 0.85 244880.0 121000.0 1.0 1.3042 0.9966 1094620 SPBio_002717 CC(C[N+](C)(C)C)OC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H20 compound treatment 216440.0 95800.0 0.82 215000.0 90800.0 0.75 1.108 0.9992 1670 SPBio_002718 Nc1nc2n(COC(CO)CO)cnc2c(=O)[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H21 compound treatment 203920.0 83300.0 0.71 199600.0 75400.0 0.62 0.9425 0.998 1246 SPBio_002719 CC[N+]1(C)CCCC(C1)OC(=O)C(O)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H22 compound treatment 104400.0 -16300.0 -0.14 122960.0 -1220.0 -0.01 -0.105 -0.7565 727 SPBio_002720 CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H23 mock treatment 142080.0 21400.0 0.18 141560.0 17400.0 0.14 0.2307 0.9931 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 H24 mock treatment 84720.0 -35900.0 -0.31 91000.0 -33200.0 -0.27 -0.4104 -0.9985 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I01 mock treatment 135720.0 15100.0 0.13 111520.0 -12700.0 -0.1 0.0167 0.1006 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I02 mock treatment 99200.0 -21500.0 -0.18 112160.0 -12000.0 -0.1 -0.1995 -0.9591 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I03 compound treatment 90040.0 -30600.0 -0.26 105200.0 -19000.0 -0.16 -0.2953 -0.9705 3069520 SPBio_002721 COc1ccc2CC3N(CCc4cc(OC)c(O)cc34)Cc2c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I04 compound treatment 165920.0 45300.0 0.39 178400.0 54200.0 0.45 0.5897 0.9971 3069541 SPBio_002722 C[C@H]1[C@H]2[C@H](OC1=O)[C@H]3C(=CC(=O)C3=C(C)C[C@@H]2O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I05 compound treatment 208640.0 88000.0 0.75 222080.0 97900.0 0.81 1.1024 0.9992 3069521 SPBio_002723 CCC1[C@@H](O)N2C3C[C@@]45[C@H](O)C3C1CC2[C@@H]5N(C)c6ccccc64 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I06 compound treatment 195920.0 75300.0 0.64 241240.0 117000.0 0.97 1.1379 0.9799 3187625 SPBio_002724 CC[N+]1(C)C2CCC1CC(C2)OC(=O)[C@H]3CCC(C(=O)OC4CC5CCC(C4)[N+]5(C)CC)(c6ccccc6)c7ccccc37 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I07 compound treatment 198480.0 77800.0 0.66 195920.0 71700.0 0.59 0.8882 0.9985 1539 SPBio_002725 C[C@H]1C(=O)O[C@@H]2CCN3CC=C(COC(=O)[C@](C)(O)[C@]1(C)O)[C@H]23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I08 compound treatment 233760.0 113000.0 0.96 237440.0 113000.0 0.94 1.3435 0.9999 3173628 SPBio_002726 CN1C(C)(C)CCCC1(C)C.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I09 compound treatment 21760.0 -98900.0 -0.84 22760.0 -101000.0 -0.84 -1.1887 -1.0 3069522 SPBio_002727 COc1cc(/C=C/C(=O)N2CCC=CC2=O)cc(OC)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I10 compound treatment 227200.0 107000.0 0.91 243160.0 119000.0 0.98 1.3375 0.9992 3069542 SPBio_002728 COC(C)C(O)(C(C)C)C(=O)OCC1=CCN2CC[C@H](O)[C@H]21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I11 compound treatment 240560.0 120000.0 1.02 222960.0 98800.0 0.82 1.2997 0.9939 3100 SPBio_002729 COc1c2OCOc2cc3CCN(C)Cc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I12 compound treatment 244200.0 124000.0 1.05 247480.0 123000.0 1.02 1.4651 0.9999 3487155 SPBio_002730 C1CNC2C(C1)C3CCC2C4N3CCc5c4[nH]c6ccccc56 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I13 compound treatment 267160.0 147000.0 1.25 275600.0 151000.0 1.25 1.7678 1.0 3189574 SPBio_002731 O[C@H]([C@@H]1CC2CCN1C[C@@H]2C=C)c3ccnc4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I14 compound treatment 128480.0 7820.0 0.07 143760.0 19600.0 0.16 0.1617 0.9229 3069543 SPBio_002732 O[C@H]1C=C2CCN3Cc4cc5OCOc5cc4[C@@H](C32)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I15 compound treatment 130200.0 9540.0 0.08 143120.0 18900.0 0.16 0.1683 0.9532 1039 SPBio_002733 CC[C@]1(CCCN2CCc3c4[C@@H]21)CC(=O)n4c5ccccc35 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I16 compound treatment 253160.0 133000.0 1.13 255960.0 132000.0 1.09 1.5686 0.9999 3187744 SPBio_002734 CCN1C[C@]2(C)CC[C@H](O)C3(C4C[C@H]5C(O)C4[C@](O)(C[C@@H]5OC)C6CC32)[C@H]61 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I17 compound treatment 256320.0 136000.0 1.16 259840.0 136000.0 1.12 1.6104 0.9999 3069523 SPBio_002735 O[C@@H]([C@H]1CC2CCN1C[C@H]2C=C)c3ccnc4ccccc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I18 compound treatment 151080.0 30400.0 0.26 145760.0 21600.0 0.18 0.3094 0.9835 3187745 SPBio_002736 C[C@@]12CC[C@H]3[C@@H](CCc4cc(OS(=O)(=O)O)ccc34)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I19 compound treatment 222640.0 102000.0 0.87 230400.0 106000.0 0.88 1.2354 1.0 3189575 SPBio_002737 N[C@H](CCONC(=N)N)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I20 compound treatment 189800.0 69100.0 0.59 205320.0 81100.0 0.67 0.8909 0.9979 3069544 SPBio_002738 CO[C@@H]1C=C2CCN(C)[C@@H]2C3[C@H]1OC(=O)c4cc5OCOc5cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I21 compound treatment 150200.0 29500.0 0.25 200120.0 75900.0 0.63 0.6221 0.9193 1530 SPBio_002739 COc1ccc2c3CCN=C(C)c3[nH]c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I22 compound treatment 190760.0 70100.0 0.6 202520.0 78300.0 0.65 0.8803 0.9992 3187746 SPBio_002740 CCN1C[C@]2(C)CC[C@H](O)C3(C2CC4[C@H]13)C5C[C@H](O)C6C[C@]45[C@H](O)C6=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I23 mock treatment 146200.0 25500.0 0.22 169040.0 44900.0 0.37 0.4162 0.9676 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 I24 mock treatment 117960.0 -2700.0 -0.02 112040.0 -12100.0 -0.1 -0.0872 -0.8469 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J01 mock treatment 185280.0 64600.0 0.55 169960.0 45800.0 0.38 0.6569 0.9834 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J02 mock treatment 156520.0 35900.0 0.31 121600.0 -2580.0 -0.02 0.2008 0.6562 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J03 compound treatment 101960.0 -18700.0 -0.16 113320.0 -10900.0 -0.09 -0.1761 -0.9633 1429 SPBio_002741 CCCCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J04 compound treatment 117960.0 -2700.0 -0.02 132440.0 8260.0 0.07 0.0321 0.4452 3187888 SPBio_002742 O=C1OC2(C[C@H]3C=CC2=C1)[C@H]4CCCCN34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J05 compound treatment 218880.0 98200.0 0.84 175600.0 51400.0 0.43 0.8922 0.9508 867 SPBio_002743 Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J06 compound treatment 139440.0 18800.0 0.16 134640.0 10500.0 0.09 0.1743 0.9584 3044756 SPBio_002744 CC(CN(C)C)CN1c2ccccc2Sc3ccccc13.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J07 compound treatment 213280.0 92600.0 0.79 217560.0 93400.0 0.77 1.1039 0.9999 1001 SPBio_002745 CN(C)CCOC(=O)COc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J08 compound treatment 232320.0 112000.0 0.95 251480.0 127000.0 1.05 1.417 0.9987 3187889 SPBio_002746 CCOc1ccc2ccccc2c1C(=O)N[C@H]3[C@H]4SC(C)(C)[C@@H](N4C3=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J09 compound treatment 235840.0 115000.0 0.98 235120.0 111000.0 0.92 1.3425 0.9995 3069584 SPBio_002747 [O-][N+](=O)c1ccc(/C=N/N2CC(CN3CCOCC3)OC2=O)o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J10 compound treatment 231800.0 111000.0 0.95 235960.0 112000.0 0.92 1.323 0.9999 1057 SPBio_002748 OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J11 compound treatment 215000.0 94300.0 0.8 247640.0 123000.0 1.02 1.2902 0.9929 837 SPBio_002749 CCOc1ccc2NC(C)(C)C=C(C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J12 compound treatment 266920.0 146000.0 1.25 260560.0 136000.0 1.13 1.6784 0.9988 3069693 SPBio_002750 CN(C)CCCO[C@H]1[C@H](OC2OC(C)(C)O[C@@H]12)C(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J13 compound treatment 241080.0 120000.0 1.03 248840.0 125000.0 1.03 1.4543 1.0 2575 SPBio_002751 CCS(=O)(=O)CCn1c(C)ncc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J14 compound treatment 129280.0 8620.0 0.07 126680.0 2500.0 0.02 0.0666 0.8725 2710 SPBio_002752 COc1ccc2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(O)C#C)[C@@H]3CCc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J15 compound treatment 222240.0 102000.0 0.86 262440.0 138000.0 1.14 1.4204 0.9905 3187758 SPBio_002753 NC(=N)NCC1COC2(CCCCC2)O1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J16 compound treatment 234200.0 114000.0 0.97 246040.0 122000.0 1.01 1.3965 0.9998 3452 SPBio_002754 CC(C)(C)NC[C@H](O)COc1cccc2C(=O)CCCc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J17 compound treatment 208000.0 87300.0 0.74 194880.0 70700.0 0.58 0.9394 0.9929 3060003 SPBio_002755 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H](O)C3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J18 compound treatment 250520.0 130000.0 1.11 212120.0 87900.0 0.73 1.2963 0.9794 3487254 SPBio_002756 CC(=O)N(CC(O)CN(C(=O)C)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I)c2c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c2I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J19 compound treatment 234000.0 113000.0 0.97 243680.0 120000.0 0.99 1.3814 0.9999 1094 SPBio_002757 COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J20 compound treatment 229800.0 109000.0 0.93 221360.0 97200.0 0.8 1.2256 0.9974 3069696 SPBio_002758 CN(C)[C@H]1C2CC3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCN4CCCC4)C(=O)c5c(O)cccc5[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J21 compound treatment 202400.0 81700.0 0.7 214800.0 90600.0 0.75 1.0223 0.9993 888 SPBio_002759 CC(C)[N+](C)(CCC(C(=O)N)(c1ccccc1)c2ccccc2)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J22 compound treatment 128680.0 8020.0 0.07 161000.0 36800.0 0.3 0.2637 0.8447 1405 SPBio_002760 C[C@@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J23 mock treatment 168160.0 47500.0 0.4 179280.0 55100.0 0.46 0.6083 0.9982 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 J24 mock treatment 132480.0 11800.0 0.1 150880.0 26700.0 0.22 0.2274 0.9367 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K01 mock treatment 176000.0 55300.0 0.47 183520.0 59300.0 0.49 0.6803 0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K02 mock treatment 127240.0 6580.0 0.06 163280.0 39100.0 0.32 0.2684 0.8175 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K03 compound treatment 123600.0 2940.0 0.03 132120.0 7940.0 0.07 0.0642 0.9127 1578 SPBio_002761 CC1=NCCc2c1[nH]c3cc(O)ccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K04 compound treatment 111480.0 -9180.0 -0.08 118160.0 -6020.0 -0.05 -0.0904 -0.9763 3187747 SPBio_002762 COc1cc(ccc1O)C(=O)OC2CC3CCC(C2)N3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K05 compound treatment 170440.0 49800.0 0.42 182640.0 58500.0 0.48 0.6417 0.9978 1043296 SPBio_002763 Cc1nccc2c3ccc(O)cc3[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K06 compound treatment 241200.0 121000.0 1.03 284320.0 160000.0 1.32 1.6625 0.992 3187748 SPBio_002764 CC(=O)O[C@H]1C2[C@]3([C@H]4[C@@H]5[C@@H](O)[C@@H]1C(=C)CC52CC6C37)[C@H](OC(=O)C)[C@H](C[C@@]7(C)CN46)OC(=O)c8ccccc8 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K07 compound treatment 136560.0 15900.0 0.14 155680.0 31500.0 0.26 0.28 0.9535 297849 SPBio_002765 COc1ccc2c(c1)[nH]c3c(C)nccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K08 compound treatment 157240.0 36600.0 0.31 173960.0 49800.0 0.41 0.5115 0.9905 1047 SPBio_002766 CN(C)CCCN1c2ccccc2Sc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K09 compound treatment 21320.0 -99300.0 -0.85 22960.0 -101000.0 -0.84 -1.1901 -1.0 2057 SPBio_002767 Cc1c2[nH]c3ccccc3c2c(C)c4cnccc14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K10 compound treatment 239840.0 119000.0 1.01 300800.0 177000.0 1.46 1.7507 0.9841 1177 SPBio_002768 Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K11 compound treatment 23400.0 -97300.0 -0.83 26840.0 -97300.0 -0.81 -1.1549 -0.9999 3069524 SPBio_002769 O=C1C=CC(=O)c2c1ccc3c2ccc4ccccc43 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K12 compound treatment 209880.0 89200.0 0.76 244200.0 120000.0 0.99 1.2393 0.9913 1463 SPBio_002770 COc1ccc(cc1)c2cc(=O)c3c(O)cc(O)cc3o2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K13 compound treatment 243320.0 123000.0 1.04 253480.0 129000.0 1.07 1.4949 0.9999 3189576 SPBio_002771 CN(CCCCCCCCCCN(C)C(=O)Oc1ccccc1[N+](C)(C)C)C(=O)Oc2ccccc2[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K14 compound treatment 258080.0 137000.0 1.17 267760.0 144000.0 1.19 1.6673 1.0 1424515 SPBio_002772 CCN1C(=O)NC(C1=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K15 compound treatment 311320.0 191000.0 1.62 223480.0 99300.0 0.82 1.7288 0.9502 1494 SPBio_002773 C1CN(CCN1)c2ccc3ccccc3n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K16 compound treatment 251400.0 131000.0 1.11 260360.0 136000.0 1.13 1.5838 1.0 3069570 SPBio_002774 C[C@@]12CCC3[C@@H](CC[C@@H]4C[C@H](O)CC[C@@]43C)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K17 compound treatment 224240.0 104000.0 0.88 267080.0 143000.0 1.18 1.4596 0.9896 3069525 SPBio_002775 C1CCN2C[C@@H]3C[C@H](CN4CCCC[C@H]34)[C@@H]2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K18 compound treatment 214920.0 94300.0 0.8 247280.0 123000.0 1.02 1.2876 0.9931 1444 SPBio_002776 C1CN=C(N1)C2CCCc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K19 compound treatment 221920.0 101000.0 0.86 289200.0 165000.0 1.37 1.575 0.9754 3043 SPBio_002777 C[C@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)C)C(=O)COC(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K20 compound treatment 17920.0 -103000.0 -0.87 18360.0 -106000.0 -0.88 -1.2375 -1.0 1070 SPBio_002778 CCC(C(CC)c1ccc(O)cc1)c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K21 compound treatment 179720.0 59100.0 0.5 179760.0 55600.0 0.46 0.6807 0.999 1035065 SPBio_002779 Cc1nccc2c3ccccc3[nH]c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K22 compound treatment 194360.0 73700.0 0.63 223200.0 99000.0 0.82 1.023 0.9913 1000312 SPBio_002780 CO[C@]1(NC(=O)CSCC#N)[C@H]2SCC(=C(N2C1=O)C(=O)O)CSc3nnnn3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K23 mock treatment 155640.0 35000.0 0.3 192440.0 68300.0 0.56 0.6099 0.9553 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 K24 mock treatment 179840.0 59200.0 0.5 194920.0 70700.0 0.59 0.7701 0.9972 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L01 mock treatment 174600.0 53900.0 0.46 148920.0 24700.0 0.2 0.4695 0.9337 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L02 mock treatment 164440.0 43800.0 0.37 151520.0 27300.0 0.23 0.4236 0.9713 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L03 compound treatment 159000.0 38300.0 0.33 171400.0 47200.0 0.39 0.5071 0.996 3187759 SPBio_002781 CCC(=O)OCC(=O)C1(OC(=O)CC)[C@H](C)C[C@H]2[C@@H]3[C@H](Cl)CC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L04 compound treatment 173600.0 52900.0 0.45 179120.0 54900.0 0.45 0.6402 1.0 712 SPBio_002782 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)CSc3ccncc3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L05 compound treatment 183880.0 63200.0 0.54 187960.0 63800.0 0.53 0.7538 1.0 1499 SPBio_002783 Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L06 compound treatment 298080.0 177000.0 1.51 281800.0 158000.0 1.3 1.9902 0.9973 3187892 SPBio_002784 C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(=C(C(=O)N)C(=O)C3(O)C(=C2C(=O)c4c(O)cccc14)O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L07 compound treatment 218840.0 98200.0 0.84 282400.0 158000.0 1.31 1.5167 0.9765 3069624 SPBio_002785 CC[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]2CC[C@@]1(O)C#C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L08 compound treatment 303360.0 183000.0 1.56 253960.0 130000.0 1.07 1.8592 0.9836 1000323 SPBio_002786 N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L09 compound treatment 241400.0 121000.0 1.03 281360.0 157000.0 1.3 1.6464 0.9932 3187760 SPBio_002787 CC(=O)OCC(=O)[C@]12OC(C)(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]31C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L10 compound treatment 279240.0 159000.0 1.35 254600.0 130000.0 1.08 1.7177 0.9938 3187893 SPBio_002788 CC[C@H]1OC(=O)[C@H](C)[C@@H](OC2CC(C)(OC)C(O)C(C)O2)[C@H](C)[C@@H](OC3OC(C)CC(C3O)N(C)C)[C@](C)(O)C[C@@H](C)/C(=N\OCOCCOC)/[C@H](C)[C@@H](O)[C@]1(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L11 compound treatment 255840.0 135000.0 1.15 306280.0 182000.0 1.51 1.8791 0.9912 934 SPBio_002789 Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L12 compound treatment 291800.0 171000.0 1.46 280040.0 156000.0 1.29 1.9421 0.9981 1000270 SPBio_002790 CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L13 compound treatment 284040.0 163000.0 1.39 308520.0 184000.0 1.53 2.062 0.9989 896 SPBio_002791 COc1ccccc1OCC(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L14 compound treatment 258800.0 138000.0 1.18 251440.0 127000.0 1.05 1.5761 0.9985 865 SPBio_002792 Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L15 compound treatment 24200.0 -96500.0 -0.82 23880.0 -100000.0 -0.83 -1.1674 -1.0 1324 SPBio_002793 CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L16 compound treatment 269960.0 149000.0 1.27 255400.0 131000.0 1.09 1.6665 0.9969 3069698 SPBio_002794 CC(C)(C)NC[C@@H](O)COc1cccc2C(=O)CCCc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L17 compound treatment 114680.0 -5980.0 -0.05 202560.0 78400.0 0.65 0.4225 0.6496 1338 SPBio_002795 CCCC(C(=O)OCCN(CC)CC)(c1ccccc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L18 compound treatment 194920.0 74300.0 0.63 226760.0 103000.0 0.85 1.0472 0.9895 1215118 SPBio_002796 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)C4COc5ccccc5O4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L19 compound treatment 219400.0 98700.0 0.84 329400.0 205000.0 1.7 1.795 0.9475 1533 SPBio_002797 Cc1cc(CC(=O)O)n(C)c1C(=O)c2ccc(Cl)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L20 compound treatment 80200.0 -40500.0 -0.34 82440.0 -41700.0 -0.35 -0.4877 -1.0 1736 SPBio_002798 CC(C)n1c(/C=C/[C@@H](O)C[C@@H](O)CC(=O)O)c(c2ccc(F)cc2)c3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L21 compound treatment 246880.0 126000.0 1.07 238440.0 114000.0 0.95 1.4283 0.998 956 SPBio_002799 CCn1nc(C(=O)O)c(=O)c2cc3OCOc3cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L22 compound treatment 190560.0 69900.0 0.6 206760.0 82600.0 0.68 0.9039 0.9976 3069699 SPBio_002800 C[C@@H]1NC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L23 mock treatment 159840.0 39200.0 0.33 184880.0 60700.0 0.5 0.591 0.9803 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 L24 mock treatment 169400.0 48700.0 0.42 178960.0 54800.0 0.45 0.6139 0.999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M01 mock treatment 187440.0 66800.0 0.57 185960.0 61800.0 0.51 0.7635 0.9986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M02 mock treatment 184240.0 63600.0 0.54 165160.0 41000.0 0.34 0.6225 0.9746 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M03 compound treatment 108480.0 -12200.0 -0.1 125280.0 1100.0 0.01 -0.0669 -0.6423 1048750 SPBio_002801 COc1ccc2[nH]c3C(=NCCc3c2c1)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M04 compound treatment 168400.0 47700.0 0.41 186560.0 62400.0 0.52 0.6524 0.993 1005 SPBio_002802 OC(CCN1CCCCC1)(C2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M05 compound treatment 211280.0 90600.0 0.77 211560.0 87400.0 0.72 1.0568 0.9995 3069526 SPBio_002803 C[N+]1(C)CCC[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M06 compound treatment 215680.0 95000.0 0.81 218480.0 94300.0 0.78 1.1237 0.9998 1603 SPBio_002804 OC(=O)CCC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2nccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M07 compound treatment 241480.0 121000.0 1.03 246720.0 123000.0 1.01 1.4443 1.0 2709 SPBio_002805 Cc1ncc(CO)c(CO)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M08 compound treatment 203800.0 83100.0 0.71 196600.0 72400.0 0.6 0.9242 0.9966 907320 SPBio_002806 CC(C)c1c(CN(C)C(C)Cc2ccccc2)n(C)n(c3ccccc3)c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M09 compound treatment 255600.0 135000.0 1.15 259400.0 135000.0 1.12 1.6034 0.9999 3189578 SPBio_002807 O=c1cccc2[C@@H]3CNCC(C3)Cn21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M10 compound treatment 255640.0 135000.0 1.15 264240.0 140000.0 1.16 1.632 1.0 955 SPBio_002808 CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M11 compound treatment 243920.0 123000.0 1.05 254680.0 131000.0 1.08 1.5055 0.9999 1039072 SPBio_002809 CN1C2CCCC1CC(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M12 compound treatment 21200.0 -99500.0 -0.85 29200.0 -95000.0 -0.79 -1.1544 -0.9993 1286 SPBio_002810 Cc1cc(ccc1OCCOCC[N+](C)(C)Cc2ccccc2)C(C)(C)CC(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M13 compound treatment 222160.0 102000.0 0.86 235240.0 111000.0 0.92 1.2608 0.9995 3189579 SPBio_002811 CC(=O)SCC(Cc1ccccc1)C(=O)NCC(=O)OCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M14 compound treatment 203280.0 82600.0 0.7 225160.0 101000.0 0.84 1.0882 0.9963 863 SPBio_002812 CN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M15 compound treatment 246680.0 126000.0 1.07 262560.0 138000.0 1.14 1.5682 0.9995 3069527 SPBio_002813 Nc1nc(=O)c2nc(CNc3ccc(cc3)C(=O)N[C@H](CCC(=O)O)C(=O)O)cnc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M16 compound treatment 213760.0 93100.0 0.79 241880.0 118000.0 0.97 1.2491 0.9948 1441 SPBio_002814 CN1CCC(CC1)OC(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M17 compound treatment 183640.0 63000.0 0.54 198400.0 74200.0 0.61 0.8134 0.9977 3189580 SPBio_002815 C[C@@H]1NCCc2cc(O)c(O)cc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M18 compound treatment 18000.0 -103000.0 -0.87 24200.0 -100000.0 -0.83 -1.2029 -0.9996 1373 SPBio_002816 CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M19 compound treatment 185880.0 65200.0 0.56 208960.0 84800.0 0.7 0.8886 0.9933 1014994 SPBio_002817 CN(C)Cc1c[nH]c2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M20 compound treatment 198240.0 77600.0 0.66 222760.0 98600.0 0.82 1.0438 0.9945 1012 SPBio_002818 Cc1cc2cc3c(C)cc(=O)oc3c(C)c2o1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M21 compound treatment 103680.0 -17000.0 -0.14 109480.0 -14700.0 -0.12 -0.1882 -0.9963 3189581 SPBio_002819 CCCCc1cc2ccccc2c(OCCN(C)C)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M22 compound treatment 28880.0 -91800.0 -0.78 28080.0 -96100.0 -0.79 -1.1147 -1.0 2117332 SPBio_002820 C[C@@]12CC[C@H]3[C@@H](CC[C@]4(O)C[C@@H](O)CC[C@]34C=O)[C@@]2(O)CC[C@@H]1C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M23 mock treatment 178440.0 57800.0 0.49 171360.0 47200.0 0.39 0.6239 0.9934 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 M24 mock treatment 135800.0 15100.0 0.13 179480.0 55300.0 0.46 0.4147 0.8724 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N01 mock treatment 180080.0 59400.0 0.51 172520.0 48300.0 0.4 0.6406 0.9932 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N02 mock treatment 195680.0 75000.0 0.64 195160.0 71000.0 0.59 0.8669 0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N03 compound treatment 179920.0 59300.0 0.5 172680.0 48500.0 0.4 0.6405 0.9936 3069627 SPBio_002821 CCC(=O)OC1([C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)CCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N04 compound treatment 211480.0 90800.0 0.77 214720.0 90500.0 0.75 1.0765 0.9999 1764 SPBio_002822 NCC1(CC(=O)O)CCCCC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N05 compound treatment 148120.0 27500.0 0.23 143360.0 19200.0 0.16 0.2776 0.9822 1001531 SPBio_002823 COc1cc(cc(OC)c1OC)[C@H]2[C@@H]3[C@H](COC3=O)[C@@H](O)c4cc5OCOc5cc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N06 compound treatment 19000.0 -102000.0 -0.87 17880.0 -106000.0 -0.88 -1.2338 -1.0 1694 SPBio_002824 Oc1ccc(cc1)c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N07 compound treatment 221360.0 101000.0 0.86 223280.0 99100.0 0.82 1.186 0.9997 877 SPBio_002825 CC(C)(Oc1ccc(Cl)cc1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N08 compound treatment 211520.0 90900.0 0.77 225400.0 101000.0 0.84 1.1392 0.9992 2764 SPBio_002826 CC(O)(P(=O)(O)O)P(=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N09 compound treatment 258880.0 138000.0 1.18 252280.0 128000.0 1.06 1.5815 0.9986 917 SPBio_002827 NS(=O)(=O)c1cc2c(NC(Cc3ccccc3)NS2(=O)=O)cc1C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N10 compound treatment 262760.0 142000.0 1.21 241120.0 117000.0 0.97 1.5396 0.9939 3069700 SPBio_002828 C[C@H]1NC(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N11 compound treatment 163880.0 43200.0 0.37 162800.0 38600.0 0.32 0.4862 0.9975 1481 SPBio_002829 Oc1c(Cc2c(O)c3ccccc3oc2=O)c(=O)oc4ccccc14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N12 compound treatment 29080.0 -91600.0 -0.78 73800.0 -50400.0 -0.42 -0.846 -0.9569 1000094 SPBio_002830 CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(=O)O3)[C@@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N13 compound treatment 244640.0 124000.0 1.06 241240.0 117000.0 0.97 1.4312 0.9991 3092 SPBio_002831 Cn1ccnc1S 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N14 compound treatment 31080.0 -89600.0 -0.76 35640.0 -88500.0 -0.73 -1.0572 -0.9998 3187895 SPBio_002832 Nc1ncn(C2O[C@H](CO)[C@H](O)[C@@H]2O)c(=O)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N15 compound treatment 235760.0 115000.0 0.98 240640.0 116000.0 0.96 1.3743 1.0 1043 SPBio_002833 O[Hg]c1c(O)c(Br)cc2c(c3ccccc3C(=O)O)c4cc(Br)c(=O)cc4oc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N16 compound treatment 231560.0 111000.0 0.94 239240.0 115000.0 0.95 1.3408 1.0 3187896 SPBio_002834 NCC1OC(O[C@@H]2C(O)[C@H](OC3C(O)C(N)CC(N)C3OC4OC(CO)C(O)C(O)C4N)O[C@@H]2CO)C(N)C(O)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N17 compound treatment 243720.0 123000.0 1.05 238960.0 115000.0 0.95 1.4124 0.9988 3187761 SPBio_002835 CC(CNC1CCCCC1)OC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N18 compound treatment 229560.0 109000.0 0.93 240320.0 116000.0 0.96 1.3351 0.9998 1267 SPBio_002836 CC(=O)Nc1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N19 compound treatment 138960.0 18300.0 0.16 178680.0 54500.0 0.45 0.429 0.8993 793 SPBio_002837 CCN(CC)CCOC(=O)C(C1CCCCC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N20 compound treatment 218280.0 97600.0 0.83 242480.0 118000.0 0.98 1.2798 0.9967 1604 SPBio_002838 OC(=O)c1ccccc1C(=O)Nc2ccc(cc2)S(=O)(=O)Nc3nccs3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N21 compound treatment 60800.0 -59900.0 -0.51 59200.0 -65000.0 -0.54 -0.7405 -0.9996 2080598 SPBio_002839 C[C@H]1C[C@H](C)C(=O)[C@@H](C1)[C@H](O)CC2CC(=O)NC(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N22 compound treatment 158200.0 37500.0 0.32 162840.0 38700.0 0.32 0.4522 1.0 2137 SPBio_002840 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccc(O)c(O)c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N23 mock treatment 187960.0 67300.0 0.57 183720.0 59500.0 0.49 0.7535 0.9972 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 N24 mock treatment 126760.0 6100.0 0.05 143400.0 19200.0 0.16 0.1492 0.8918 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O01 mock treatment 112640.0 -8020.0 -0.07 102280.0 -21900.0 -0.18 -0.1763 -0.911 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O02 mock treatment 194840.0 74200.0 0.63 178480.0 54300.0 0.45 0.7643 0.9861 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O03 compound treatment 200840.0 80200.0 0.68 187320.0 63100.0 0.52 0.8521 0.9913 3382 SPBio_002841 Cc1c(CCO)sc[n+]1Cc2cnc(C)nc2N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O04 compound treatment 312640.0 192000.0 1.63 258760.0 135000.0 1.11 1.9431 0.9825 1155 SPBio_002842 Nc1ccc(cc1)S(=O)(=O)NC(=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O05 compound treatment 207320.0 86700.0 0.74 185480.0 61300.0 0.51 0.8804 0.9833 3487152 SPBio_002843 CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O06 compound treatment 220360.0 99700.0 0.85 183920.0 59700.0 0.49 0.9498 0.9669 1513 SPBio_002844 CCOC(=O)c1ccc(N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O07 compound treatment 264000.0 143000.0 1.22 228440.0 104000.0 0.86 1.4729 0.9856 2041 SPBio_002845 OC(=O)CNC(=O)C(CS)Cc1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O08 compound treatment 248000.0 127000.0 1.08 295120.0 171000.0 1.41 1.7666 0.9914 1242 SPBio_002846 CN(CS(=O)(=O)O)c1c(C)n(C)n(c2ccccc2)c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O09 compound treatment 233840.0 113000.0 0.96 314600.0 190000.0 1.58 1.7953 0.9722 1015808 SPBio_002847 Cc1cc2nc3c(=O)[nH]c(=O)nc3n(CC(O)C(O)C(O)CO)c2cc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O10 compound treatment 251880.0 131000.0 1.12 259720.0 136000.0 1.12 1.5829 1.0 1064 SPBio_002848 [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@H](CO[C@H]12)O[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O11 compound treatment 271400.0 151000.0 1.28 282520.0 158000.0 1.31 1.8338 0.9999 3189582 SPBio_002849 CC[C@H]1CN2CCC1C[C@H]2[C@H](O)c3ccnc4ccc(OC)cc34 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O12 compound treatment 251880.0 131000.0 1.12 259280.0 135000.0 1.12 1.5803 1.0 1668673 SPBio_002850 Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O13 compound treatment 235600.0 115000.0 0.98 234880.0 111000.0 0.92 1.3396 0.9995 824 SPBio_002851 CC[C@]1(CCCN2CCc3c4[C@@H]21)C[C@@](O)(C(=O)OC)n4c5ccccc35 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O14 compound treatment 72040.0 -48600.0 -0.41 71360.0 -52800.0 -0.44 -0.6017 -0.9996 1467 SPBio_002852 CCCCOc1ccc(OCCCN2CCOCC2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O15 compound treatment 246120.0 125000.0 1.07 237040.0 113000.0 0.93 1.4156 0.9977 3069528 SPBio_002853 C/C=C\1/C[C@@H](C)[C@](O)(CO)C(=O)OCC2=CCN3CC[C@@H](OC1=O)[C@H]32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O16 compound treatment 247560.0 127000.0 1.08 220160.0 96000.0 0.79 1.3255 0.9885 3069574 SPBio_002854 CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O17 compound treatment 306040.0 185000.0 1.58 227680.0 104000.0 0.86 1.7216 0.9587 3187609 SPBio_002855 C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O18 compound treatment 206280.0 85600.0 0.73 238280.0 114000.0 0.94 1.183 0.9918 2081008 SPBio_002856 C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O19 compound treatment 230720.0 110000.0 0.94 204720.0 80500.0 0.67 1.1338 0.986 3187610 SPBio_002857 CC[C@@H](C)C(=O)O[C@H]1[C@H](O)[C@H]2[C@@H](CN3C[C@@H](C)CC[C@H]3[C@@]2(C)O)C4C[C@]5(O[C@]6(O)[C@H]7[C@@H](OC(=O)C)[C@@H](OC(=O)C)[C@H]5[C@@]41O)[C@@]7(C)CC[C@@H]6OC(=O)C(C)(O)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O20 compound treatment 239080.0 118000.0 1.01 253720.0 130000.0 1.07 1.4708 0.9995 759 SPBio_002858 CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc3cccs3)C2=O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O21 compound treatment 224480.0 104000.0 0.88 176640.0 52500.0 0.43 0.932 0.9464 3069529 SPBio_002859 C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]6(C[C@@H](O[C@@H]7OC(CO)[C@@H](O)[C@@H](O)C7O)[C@@H](O)C(CO)O6)O[C@H]8OC(C)[C@H](O)[C@H](O)C8O)N9C[C@@H](C)CC[C@H]19 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O22 compound treatment 192520.0 71900.0 0.61 204320.0 80100.0 0.66 0.9015 0.9992 3187749 SPBio_002860 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)COC(=O)N)\c3ccco3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O23 mock treatment 183280.0 62600.0 0.53 207480.0 83300.0 0.69 0.8643 0.992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 O24 mock treatment 110280.0 -10400.0 -0.09 155040.0 30900.0 0.26 0.1181 0.437 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P01 mock treatment 34760.0 -85900.0 -0.73 35040.0 -89100.0 -0.74 -1.0386 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P02 mock treatment 83400.0 -37300.0 -0.32 82000.0 -42200.0 -0.35 -0.471 -0.9989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P03 compound treatment 120200.0 -456.0 0.0 89400.0 -34800.0 -0.29 -0.2062 -0.7166 890 SPBio_002861 COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P04 compound treatment 156320.0 35700.0 0.3 141720.0 17500.0 0.15 0.3173 0.9429 3069701 SPBio_002862 C[C@H](O)C(=O)Nc1c(I)c(C(=O)NC(CO)CO)c(I)c(C(=O)NC(CO)CO)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P05 compound treatment 183880.0 63200.0 0.54 199640.0 75500.0 0.62 0.8221 0.9973 244 SPBio_002863 CC[N+](C)(CC)CCC[n+]1c(c2ccccc2)c3cc(N)ccc3c4ccc(N)cc14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P06 compound treatment 247480.0 127000.0 1.08 218240.0 94100.0 0.78 1.3138 0.9871 3487261 SPBio_002864 COCC(=O)Nc1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)N(C)CC(O)CO)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P07 compound treatment 153280.0 32600.0 0.28 162920.0 38700.0 0.32 0.4231 0.9975 1431 SPBio_002865 Clc1ccc(cc1)C(OCCN2CCCCC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P08 compound treatment 190400.0 69700.0 0.59 240520.0 116000.0 0.96 1.1005 0.9731 856 SPBio_002866 Cn1c(=O)n(C)c2nc[nH]c2c1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P09 compound treatment 223440.0 103000.0 0.88 252080.0 128000.0 1.06 1.367 0.9956 3187762 SPBio_002867 CC1CC(CC(C)(C)N1C)OC(=O)C(O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P10 compound treatment 256280.0 136000.0 1.15 262560.0 138000.0 1.14 1.626 1.0 1222 SPBio_002868 Cn1cnc2n(C)c(=O)[nH]c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P11 compound treatment 253880.0 133000.0 1.13 327480.0 203000.0 1.68 1.9913 0.9816 3383 SPBio_002869 Cc1cc(no1)C(=O)NNCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P12 compound treatment 242320.0 122000.0 1.04 274040.0 150000.0 1.24 1.6091 0.996 687 SPBio_002870 CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P13 compound treatment 135040.0 14400.0 0.12 142720.0 18500.0 0.15 0.1951 0.9938 2105063 SPBio_002871 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3CC[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P14 compound treatment 247320.0 127000.0 1.08 290520.0 166000.0 1.38 1.7356 0.9927 989 SPBio_002872 NC(=N)NCCCCNC(=N)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P15 compound treatment 142920.0 22300.0 0.19 140280.0 16100.0 0.13 0.2282 0.9851 2752 SPBio_002873 COc1ccc2Sc3ccccc3N(C[C@H](C)CN(C)C)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P16 compound treatment 230000.0 109000.0 0.93 275320.0 151000.0 1.25 1.5424 0.9895 3060919 SPBio_002874 CN1C2CC(CC1C3OC32)OC(=O)[C@H](CO)c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P17 compound treatment 14320.0 -106000.0 -0.91 15080.0 -109000.0 -0.9 -1.2784 -1.0 1370 SPBio_002875 C/C=C(/C(=C/C)/c1ccc(O)cc1)\c2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P18 compound treatment 225440.0 105000.0 0.89 269280.0 145000.0 1.2 1.4797 0.9893 3487262 SPBio_002876 OCCN(C(=O)CO)c1c(I)c(C(=O)NCC(O)CO)c(I)c(C(=O)NCC(O)CO)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P19 compound treatment 185240.0 64600.0 0.55 195920.0 71700.0 0.59 0.8085 0.9993 1328 SPBio_002877 OC(CCN1CCCCC1)(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P20 compound treatment 126000.0 5340.0 0.05 129040.0 4860.0 0.04 0.0606 0.9981 446 SPBio_002878 COc1cc(CNC(=O)CCCC/C=C/C(C)C)ccc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P21 compound treatment 153680.0 33000.0 0.28 173040.0 48900.0 0.4 0.4847 0.9843 794 SPBio_002879 Nc1cc(c[nH]c1=O)c2ccncc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P22 compound treatment 116400.0 -4260.0 -0.04 142000.0 17800.0 0.15 0.0786 0.5179 1327 SPBio_002880 C[N+](C)(C)CCOC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P23 mock treatment 90800.0 -29900.0 -0.25 82960.0 -41200.0 -0.34 -0.4209 -0.9895 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2166 P24 mock treatment 48280.0 -72400.0 -0.62 60760.0 -63400.0 -0.52 -0.8067 -0.9968 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A01 mock treatment 81200.0 -82900.0 -0.71 68320.0 -76800.0 -0.64 -0.9483 -0.9986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A02 mock treatment 126600.0 -37500.0 -0.32 122080.0 -23000.0 -0.19 -0.3605 -0.9694 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A03 compound treatment 90000.0 -74100.0 -0.63 137120.0 -7980.0 -0.07 -0.4929 -0.7768 1300 SPBio_002881 OC(=O)c1cccnc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A04 compound treatment 90880.0 -73200.0 -0.62 158600.0 13500.0 0.11 -0.3619 -0.5714 1073908 SPBio_002882 CC[N+](CC)(CC(=O)Nc1c(C)cccc1C)Cc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A05 compound treatment 79880.0 -84200.0 -0.72 231720.0 86600.0 0.72 -4.0E-4 -4.0E-4 2819 SPBio_002883 CCC1(C)CC(=O)NC(=O)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A06 compound treatment 89400.0 -74700.0 -0.64 220000.0 74900.0 0.62 -0.0117 -0.0132 1322 SPBio_002884 COc1cc2ccc(=O)oc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A07 compound treatment 10120.0 -154000.0 -1.31 20960.0 -124000.0 -1.03 -1.6533 -0.9927 3187897 SPBio_002885 C[C@]12[C@H](CC[C@]2(O)[C@@H]3CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3C[C@H]1O)C5=CC(=O)OC5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A08 compound treatment 36800.0 -127000.0 -1.08 175200.0 30100.0 0.25 -0.5904 -0.5308 1081653 SPBio_002886 Clc1ccc(C(Cn2ccnc2)OCC=C)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A09 compound treatment 55800.0 -108000.0 -0.92 245800.0 101000.0 0.83 -0.0631 -0.0507 4370 SPBio_002887 CNCC(O)C(O)C(O)C(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A10 compound treatment 82120.0 -82000.0 -0.7 268360.0 123000.0 1.02 0.2274 0.184 1203 SPBio_002888 CN(C)[C@H]1[C@@H]2[C@@H](O)[C@@H]3C(=C)c4cccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A11 compound treatment 8400.0 -156000.0 -1.33 15920.0 -129000.0 -1.07 -1.6932 -0.9943 3172726 SPBio_002889 C[C@]12C3CCC(O3)[C@]2(C)C(=O)OC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A12 compound treatment 176640.0 12500.0 0.11 226320.0 81200.0 0.67 0.5505 0.8092 2060138 SPBio_002890 C[C@]1([C@H]2[C@H](C(=O)O)[C@]3(CC(=C)[C@@]4(O)C3)[C@@H](CC4)[C@]52OC1=O)[C@@H](O)C=C5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A13 compound treatment 8240.0 -156000.0 -1.33 14480.0 -131000.0 -1.08 -1.7025 -0.9948 1999 SPBio_002891 Oc1c(I)cc(Cl)c2cccnc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A14 compound treatment 112240.0 -51900.0 -0.44 256800.0 112000.0 0.92 0.3411 0.333 3480627 SPBio_002892 CC(C)NCC(O)c1ccc(NS(=O)(=O)C)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A15 compound treatment 76480.0 -87600.0 -0.75 216000.0 70900.0 0.59 -0.1129 -0.1189 838 SPBio_002893 COc1ccc(C(=O)c2ccccc2)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A16 compound treatment 63320.0 -101000.0 -0.86 249360.0 104000.0 0.86 0.003 0.0025 3188025 SPBio_002894 CN1C2CC(O)C1CC(=O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A17 compound treatment 42160.0 -122000.0 -1.04 160840.0 15700.0 0.13 -0.6422 -0.6136 681 SPBio_002895 CC(CN1c2ccccc2Sc3ccccc13)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A18 compound treatment 60520.0 -104000.0 -0.88 228680.0 83600.0 0.69 -0.1348 -0.1203 3855 SPBio_002896 C[N+](C)(C)CCCCCCCCCC[N+](C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A19 compound treatment 116840.0 -47300.0 -0.4 228720.0 83600.0 0.69 0.2045 0.2555 1225 SPBio_002897 Oc1cc(O)c2c(=O)cc(oc2c1)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A20 compound treatment 76680.0 -87400.0 -0.74 199920.0 54800.0 0.45 -0.2057 -0.236 1040327 SPBio_002898 CC(=O)Nc1cc2ccccc2oc1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A21 compound treatment 111440.0 -52700.0 -0.45 178880.0 33800.0 0.28 -0.1195 -0.2262 3487233 SPBio_002899 CC(O)Cn1cnc2n(C)c(=O)n(C)c(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A22 compound treatment 116400.0 -47700.0 -0.41 163480.0 18400.0 0.15 -0.1798 -0.4144 1120 SPBio_002900 Oc1ccc(cc1[N+](=O)[O-])[As](=O)(O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A23 mock treatment 113680.0 -50400.0 -0.43 105320.0 -39800.0 -0.33 -0.5364 -0.9914 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 A24 mock treatment 133240.0 -30900.0 -0.26 69000.0 -76100.0 -0.63 -0.6311 -0.925 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B01 mock treatment 124200.0 -39900.0 -0.34 142520.0 -2580.0 -0.02 -0.2554 -0.75 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B02 mock treatment 78200.0 -85900.0 -0.73 188560.0 43500.0 0.36 -0.263 -0.3227 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B03 compound treatment 89120.0 -75000.0 -0.64 204040.0 58900.0 0.49 -0.1067 -0.1328 3069812 SPBio_002901 CCOC(=O)c1cncn1C(C)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B04 mock treatment 81080.0 -83000.0 -0.71 220680.0 75600.0 0.63 -0.0578 -0.0612 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B05 compound treatment 84440.0 -79700.0 -0.68 226440.0 81300.0 0.67 -0.0039 -0.0041 3188157 SPBio_002902 CC[N+](CC)(CC)CCC(O)(C1CCCCC1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B06 mock treatment 105160.0 -59000.0 -0.5 231200.0 86100.0 0.71 0.1487 0.1707 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B07 compound treatment 38120.0 -126000.0 -1.07 224520.0 79400.0 0.66 -0.294 -0.2337 3487585 SPBio_002903 CC(C)(C)NCC(O)COc1ccccc1C2CCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B08 mock treatment 51320.0 -113000.0 -0.96 267720.0 123000.0 1.01 0.0382 0.0273 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B09 compound treatment 44960.0 -119000.0 -1.01 258400.0 113000.0 0.94 -0.0546 -0.0395 3188158 SPBio_002904 CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C)C(=O)COC(=O)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B10 mock treatment 73640.0 -90500.0 -0.77 238640.0 93500.0 0.77 0.0025 0.0023 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B11 compound treatment 9120.0 -155000.0 -1.32 17680.0 -127000.0 -1.05 -1.6785 -0.9938 3069813 SPBio_002905 Clc1ccc(C(Cn2ccnc2)OCc3csc4c(Cl)cccc34)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B12 mock treatment 180800.0 16700.0 0.14 204600.0 59500.0 0.49 0.4485 0.8754 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B13 compound treatment 118080.0 -46000.0 -0.39 168680.0 23600.0 0.2 -0.1392 -0.318 3188159 SPBio_002906 CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B14 mock treatment 145480.0 -18600.0 -0.16 257280.0 112000.0 0.93 0.544 0.5778 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B15 compound treatment 81280.0 -82800.0 -0.71 236280.0 91200.0 0.75 0.0347 0.0336 3168 SPBio_002907 NS(=O)(=O)c1cc(cc(N2CCCC2)c1Oc3ccccc3)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B16 mock treatment 59520.0 -105000.0 -0.89 258040.0 113000.0 0.93 0.0309 0.024 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B17 compound treatment 41960.0 -122000.0 -1.04 204000.0 58900.0 0.49 -0.3909 -0.3403 3188160 SPBio_002908 CC(=O)c1ccc2Sc3ccccc3N(CCCN4CCC(CCO)CC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B18 mock treatment 62080.0 -102000.0 -0.87 223800.0 78700.0 0.65 -0.1539 -0.1418 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B19 compound treatment 11280.0 -153000.0 -1.3 50040.0 -95100.0 -0.79 -1.4762 -0.9709 943 SPBio_002909 CCCCC1C(=O)N(N(C1=O)c2ccc(O)cc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B20 mock treatment 88320.0 -75800.0 -0.65 266240.0 121000.0 1.0 0.2523 0.2117 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B21 compound treatment 77560.0 -86600.0 -0.74 213440.0 68300.0 0.57 -0.1213 -0.1306 3069814 SPBio_002910 CCC1NC(=O)c2cc(c(Cl)cc2N1)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B22 mock treatment 106200.0 -57900.0 -0.49 213080.0 68000.0 0.56 0.049 0.0655 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B23 mock treatment 159880.0 -4240.0 -0.04 204280.0 59200.0 0.49 0.3207 0.6532 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 B24 mock treatment 150080.0 -14000.0 -0.12 93760.0 -51300.0 -0.42 -0.3848 -0.8722 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C01 mock treatment 109120.0 -55000.0 -0.47 143080.0 -2020.0 -0.02 -0.3429 -0.7319 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C02 mock treatment 120080.0 -44000.0 -0.37 178080.0 33000.0 0.27 -0.0722 -0.1557 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C03 compound treatment 95920.0 -68200.0 -0.58 178920.0 33800.0 0.28 -0.2127 -0.3301 1022907 SPBio_002911 CC(=O)c1cc2ccccc2oc1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C04 compound treatment 137280.0 -26800.0 -0.23 198200.0 53100.0 0.44 0.1491 0.301 3188026 SPBio_002912 CCN1CCC[C@H]1CNC(=O)c2c(OC)ccc(Br)c2OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C05 compound treatment 151640.0 -12500.0 -0.11 207480.0 62400.0 0.52 0.2898 0.55 3187898 SPBio_002913 OCC1O[C@@H](Oc2cc3ccc(=O)oc3cc2O)C(O)[C@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C06 compound treatment 142920.0 -21200.0 -0.18 235440.0 90300.0 0.75 0.4008 0.5214 864 SPBio_002914 Oc1noc2CNCCc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C07 compound treatment 63400.0 -101000.0 -0.86 243960.0 98900.0 0.82 -0.0281 -0.0237 2776 SPBio_002915 OC(=O)Cc1ccc(cc1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C08 compound treatment 55880.0 -108000.0 -0.92 240720.0 95600.0 0.79 -0.0923 -0.076 1134931 SPBio_002916 Cc1ccc2n3CCNC4CCCc(c43)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C09 compound treatment 79360.0 -84800.0 -0.72 235600.0 90500.0 0.75 0.0191 0.0184 1012530 SPBio_002917 CCCCOC(=O)c1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C10 compound treatment 99000.0 -65100.0 -0.55 241720.0 96600.0 0.8 0.1732 0.178 1512 SPBio_002918 CC(C)NCC(O)c1ccc2ccccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C11 compound treatment 130920.0 -33200.0 -0.28 231400.0 86300.0 0.71 0.305 0.3972 1299 SPBio_002919 Nc1ccc(cc1)C(=O)NCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C12 compound treatment 114400.0 -49700.0 -0.42 178800.0 33700.0 0.28 -0.1022 -0.2016 3480607 SPBio_002920 COc1ccccc1N2CCN(CC(O)COc3cccc4ccccc34)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C13 compound treatment 192200.0 28100.0 0.24 245600.0 101000.0 0.83 0.757 0.875 1231 SPBio_002921 CC(C)C[C@H](NC(=O)C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C14 compound treatment 94840.0 -69300.0 -0.59 222360.0 77300.0 0.64 0.0349 0.0401 907524 SPBio_002922 CCCCNc1c(C(=O)OCC)c(C)nc2n(CC)ncc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C15 compound treatment 107040.0 -57100.0 -0.49 250600.0 106000.0 0.87 0.2735 0.2738 1258 SPBio_002923 CCn1cc(C(=O)O)c(=O)c2cnc(nc12)N3CCNCC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C16 compound treatment 80600.0 -83500.0 -0.71 249240.0 104000.0 0.86 0.1064 0.0952 2372 SPBio_002924 COc1cc(ccc1OC(F)F)c2ccc(=O)[nH]n2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C17 compound treatment 93840.0 -70300.0 -0.6 218840.0 73700.0 0.61 0.0083 0.0097 3059213 SPBio_002925 COc1ccc(C(=O)c2ccccc2O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C18 compound treatment 79720.0 -84400.0 -0.72 231560.0 86500.0 0.72 -0.0023 -0.0023 733 SPBio_002926 CC1(CC2CC3(C)C1)CC(N)(C2)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C19 compound treatment 66240.0 -97900.0 -0.83 98760.0 -46300.0 -0.38 -0.8603 -0.9379 3187899 SPBio_002927 C[C@@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C20 compound treatment 110280.0 -53800.0 -0.46 224760.0 79700.0 0.66 0.1419 0.1767 2742 SPBio_002928 OC(=O)/C=C/c1ccc(Cn2ccnc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C21 compound treatment 119120.0 -45000.0 -0.38 209280.0 64200.0 0.53 0.1045 0.1597 1019709 SPBio_002929 C[N+]1(C)C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C22 compound treatment 87440.0 -76700.0 -0.65 179520.0 34400.0 0.28 -0.2603 -0.3654 2245 SPBio_002930 C(N1CCN(CC1)c2ncccn2)c3ccc4OCOc4c3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C23 mock treatment 126680.0 -37400.0 -0.32 147920.0 2820.0 0.02 -0.2089 -0.6536 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 C24 mock treatment 126400.0 -37700.0 -0.32 39680.0 -105000.0 -0.87 -0.8437 -0.9079 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D01 mock treatment 52160.0 -112000.0 -0.95 138480.0 -6620.0 -0.05 -0.7128 -0.7465 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D02 mock treatment 78560.0 -85600.0 -0.73 168160.0 23100.0 0.19 -0.3802 -0.5049 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D03 compound treatment 92200.0 -71900.0 -0.61 167120.0 22000.0 0.18 -0.3042 -0.4761 1267101 SPBio_002931 CCOC(=O)Nc1ccc2Sc3ccccc3N(C(=O)CCN4CCOCC4)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D04 mock treatment 126000.0 -38100.0 -0.32 216680.0 71600.0 0.59 0.1892 0.2802 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D05 compound treatment 111960.0 -52200.0 -0.44 187120.0 42000.0 0.35 -0.0682 -0.1209 1487 SPBio_002932 CCC(Cc1c(I)cc(I)c(N)c1I)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D06 mock treatment 167040.0 2920.0 0.02 229400.0 84300.0 0.7 0.5107 0.7319 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D07 compound treatment 84400.0 -79700.0 -0.68 231440.0 86300.0 0.71 0.0251 0.0255 3188161 SPBio_002933 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](/N=C/N3CCCCCC3)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D08 mock treatment 86720.0 -77400.0 -0.66 219360.0 74300.0 0.61 -0.0316 -0.035 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D09 compound treatment 104840.0 -59300.0 -0.5 235360.0 90300.0 0.75 0.1711 0.1899 3188162 SPBio_002934 CCC(=O)OC(Cc1ccccc1)(C(C)CN(C)C)c2ccccc2.OS(=O)(=O)c1ccc2ccccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D10 mock treatment 118320.0 -45800.0 -0.39 249800.0 105000.0 0.87 0.3367 0.3545 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D11 compound treatment 89040.0 -75100.0 -0.64 188800.0 43700.0 0.36 -0.1964 -0.2674 772 SPBio_002935 CCN1CCCC(C1)OC(=O)C(c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D12 mock treatment 198520.0 34400.0 0.29 239880.0 94800.0 0.78 0.7616 0.9098 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D13 compound treatment 143400.0 -20700.0 -0.18 174560.0 29500.0 0.24 0.0476 0.1582 3069815 SPBio_002936 OC[C@H]1O[C@H](C[C@H]1O)n2cc(c(=O)[nH]c2=O)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D14 mock treatment 147520.0 -16600.0 -0.14 246520.0 101000.0 0.84 0.4934 0.5798 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D15 compound treatment 103080.0 -61000.0 -0.52 224920.0 79800.0 0.66 0.0995 0.1184 1001977 SPBio_002937 CC(C)NCC(O)COc1ccccc1OCC=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D16 mock treatment 115600.0 -48500.0 -0.41 226000.0 80900.0 0.67 0.1811 0.2303 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D17 compound treatment 82120.0 -82000.0 -0.7 178840.0 33700.0 0.28 -0.2963 -0.3941 1434439 SPBio_002938 Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D18 mock treatment 102640.0 -61500.0 -0.52 229400.0 84300.0 0.7 0.123 0.1411 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D19 compound treatment 114360.0 -49800.0 -0.42 218240.0 73100.0 0.61 0.1283 0.1737 3069816 SPBio_002939 CCCOc1cc(N)ccc1C(=O)OCCN(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D20 mock treatment 126840.0 -37300.0 -0.32 228280.0 83200.0 0.69 0.2622 0.3459 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D21 compound treatment 91040.0 -73100.0 -0.62 186920.0 41800.0 0.35 -0.1953 -0.2744 1672 SPBio_002940 OC(=O)CCc1nc(c(o1)c2ccccc2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D22 mock treatment 110040.0 -54100.0 -0.46 185560.0 40500.0 0.33 -0.0889 -0.1561 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D23 mock treatment 118200.0 -45900.0 -0.39 167280.0 22200.0 0.18 -0.1467 -0.3397 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 D24 mock treatment 68560.0 -95600.0 -0.81 51000.0 -94100.0 -0.78 -1.1258 -0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E01 mock treatment 50880.0 -113000.0 -0.96 169440.0 24300.0 0.2 -0.5394 -0.5476 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E02 mock treatment 70520.0 -93600.0 -0.8 151640.0 6540.0 0.05 -0.5252 -0.6576 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E03 compound treatment 153080.0 -11000.0 -0.09 198120.0 53000.0 0.44 0.2437 0.5433 2732 SPBio_002941 Cc1cc(=O)oc2cc(O)ccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E04 compound treatment 117240.0 -46900.0 -0.4 183480.0 38400.0 0.32 -0.0577 -0.1131 3188027 SPBio_002942 CCN(CC)CCOC(=O)C1(CCCC1)c2ccc(cc2)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E05 compound treatment 188760.0 24600.0 0.21 225040.0 79900.0 0.66 0.616 0.8878 1978 SPBio_002943 OC(=O)/C=C/c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E06 compound treatment 146880.0 -17200.0 -0.15 208160.0 63100.0 0.52 0.2651 0.4892 2098610 SPBio_002944 C1CC1C(NC2=NCCO2)C3CC3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E07 compound treatment 111320.0 -52800.0 -0.45 226400.0 81300.0 0.67 0.1577 0.195 3069737 SPBio_002945 CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E08 compound treatment 155840.0 -8280.0 -0.07 226480.0 81400.0 0.67 0.4262 0.6296 3723 SPBio_002946 CN(C)CCCSC(=N)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E09 compound treatment 149360.0 -14800.0 -0.13 227880.0 82800.0 0.68 0.3954 0.5679 2743 SPBio_002947 CC(C)(C(=O)c1cccnc1)c2cccnc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E10 compound treatment 162680.0 -1440.0 -0.01 236480.0 91400.0 0.76 0.5259 0.6956 3069774 SPBio_002948 CO[C@H]1[C@H](O)C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E11 compound treatment 183880.0 19800.0 0.17 245720.0 101000.0 0.83 0.7076 0.8332 3202 SPBio_002949 COc1ccccc1N2CCN(CCCNc3cc(=O)n(C)c(=O)n3C)CC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E12 compound treatment 222440.0 58300.0 0.5 240000.0 94900.0 0.79 0.9063 0.9756 3069775 SPBio_002950 CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E13 compound treatment 16680.0 -147000.0 -1.26 22040.0 -123000.0 -1.02 -1.6075 -0.9946 23081 SPBio_002951 Fc1ccc(cc1)C(CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4)c5ccc(F)cc5 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E14 compound treatment 32800.0 -131000.0 -1.12 34560.0 -111000.0 -0.91 -1.4372 -0.995 3188028 SPBio_002952 CC1O[C@@H](O[C@H]2CC[C@]3(C)C4CC[C@]5(C)[C@H](CC[C@]5(O)C4CCC3=C2)c6ccc(=O)oc6)C(O)[C@@H](O)[C@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E15 compound treatment 182280.0 18200.0 0.15 241880.0 96800.0 0.8 0.6755 0.8284 1472 SPBio_002953 CC(C)Cc1ccc(cc1)[C@H](C)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E16 compound treatment 13440.0 -151000.0 -1.28 20640.0 -124000.0 -1.03 -1.6352 -0.9941 2549 SPBio_002954 C[n+]1cc2c3OCOc3ccc2c4ccc5cc6OCOc6cc5c14 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E17 compound treatment 91920.0 -72200.0 -0.61 195880.0 50800.0 0.42 -0.1376 -0.1848 3187900 SPBio_002955 CC(=O)O[C@H]1CC[C@@H]2[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(OC(=O)C)C#C)[C@@H]3CCC2=C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E18 compound treatment 129280.0 -34800.0 -0.3 219320.0 74200.0 0.61 0.2244 0.3291 3069776 SPBio_002956 C[C@]1(C[C@H](O)[C@@]2(O)C=CO[C@H](OC3OC(CO)C(O)C(O)C3O)C12)OC(=O)/C=C\c4ccccc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E19 compound treatment 187880.0 23800.0 0.2 234360.0 89300.0 0.74 0.6652 0.8688 1440 SPBio_002957 COc1ccc2cc(CCC(=O)C)ccc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E20 compound treatment 173760.0 9640.0 0.08 231760.0 86700.0 0.72 0.565 0.783 3188029 SPBio_002958 C[C@@H]1CCC2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)C5CC[C@]43C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6OC(CO[C@@H]7OC(CO)[C@@H](O[C@@H]8OC(C)[C@H](O)[C@H](O)C8O)[C@@H](O)C7O)[C@@H](O)[C@@H](O)C6O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E21 compound treatment 135040.0 -29100.0 -0.25 212320.0 67200.0 0.56 0.2182 0.3584 907434 SPBio_002959 CNCCC(Oc1ccccc1OC)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E22 compound treatment 86640.0 -77500.0 -0.66 167320.0 22200.0 0.18 -0.3365 -0.4913 3069777 SPBio_002960 CC(=C)[C@@H]1CC[C@]2(CO)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E23 mock treatment 130280.0 -33800.0 -0.29 161720.0 16600.0 0.14 -0.1065 -0.3336 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 E24 mock treatment 67680.0 -96400.0 -0.82 76280.0 -68800.0 -0.57 -0.9832 -0.984 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F01 mock treatment 37440.0 -127000.0 -1.08 174280.0 29200.0 0.24 -0.592 -0.5356 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F02 mock treatment 82640.0 -81500.0 -0.69 146600.0 1500.0 0.01 -0.4818 -0.6943 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F03 compound treatment 90240.0 -73900.0 -0.63 262240.0 117000.0 0.97 0.2405 0.2081 3188163 SPBio_002961 CN1C(=O)CC(C1=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F04 mock treatment 168080.0 3960.0 0.03 221440.0 76300.0 0.63 0.4704 0.7438 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F05 compound treatment 184560.0 20400.0 0.17 234560.0 89500.0 0.74 0.6464 0.8502 2957 SPBio_002962 CNC(=O)c1c(I)c(N(C)C(=O)C)c(I)c(C(=O)NCC(=O)Nc2c(I)c(C(=O)O)c(I)c(C(=O)NCCO)c2I)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F06 mock treatment 196560.0 32400.0 0.28 238960.0 93900.0 0.78 0.7444 0.9032 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F07 compound treatment 130240.0 -33900.0 -0.29 194160.0 49100.0 0.41 0.083 0.1668 3069817 SPBio_002963 CN(C/C=C/c1ccccc1)Cc2cccc3ccccc23 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F08 mock treatment 172120.0 8000.0 0.07 262240.0 117000.0 0.97 0.7334 0.755 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F09 compound treatment 158760.0 -5360.0 -0.05 225040.0 79900.0 0.66 0.4354 0.6568 907413 SPBio_002964 CCCNC(C)(C)COC(=O)c1ccccc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F10 mock treatment 215960.0 51800.0 0.44 256200.0 111000.0 0.92 0.962 0.9435 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F11 compound treatment 197960.0 33800.0 0.29 265520.0 120000.0 1.0 0.9082 0.8757 1666 SPBio_002965 Cc1[nH]c(=O)c(C#N)cc1c2ccncc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F12 mock treatment 245280.0 81200.0 0.69 233200.0 88100.0 0.73 1.004 0.9996 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F13 compound treatment 258680.0 94600.0 0.81 294720.0 150000.0 1.24 1.4446 0.9783 4382 SPBio_002966 CC[N+](C)(CC)CCOC(=O)C1c2ccccc2Oc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F14 mock treatment 204720.0 40600.0 0.35 235680.0 90600.0 0.75 0.7743 0.9383 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F15 compound treatment 190800.0 26700.0 0.23 265200.0 120000.0 0.99 0.8632 0.8469 2586 SPBio_002967 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C(=O)O)c3ccsc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F16 mock treatment 215200.0 51100.0 0.43 218880.0 73800.0 0.61 0.7391 0.9862 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F17 compound treatment 64440.0 -99700.0 -0.85 163920.0 18800.0 0.16 -0.49 -0.5679 3188276 SPBio_002968 CCSc1ccc2Sc3ccccc3N(CCCN4CCN(C)CC4)c2c1.OC(CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F18 mock treatment 188680.0 24600.0 0.21 218800.0 73700.0 0.61 0.579 0.8983 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F19 compound treatment 182720.0 18600.0 0.16 239120.0 94000.0 0.78 0.662 0.834 1778 SPBio_002969 Nc1ccc(O)c(c1)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F20 mock treatment 197360.0 33200.0 0.28 230000.0 84900.0 0.7 0.6968 0.9201 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F21 compound treatment 138680.0 -25400.0 -0.22 212320.0 67200.0 0.56 0.2401 0.4023 3047 SPBio_002970 C[C@H]1[C@@H]2CC[C@@]3(C)C=CC(=O)C(=C3[C@H]2OC1=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F22 mock treatment 124920.0 -39200.0 -0.33 181720.0 36600.0 0.3 -0.0218 -0.0483 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F23 mock treatment 109000.0 -55100.0 -0.47 165560.0 20500.0 0.17 -0.2121 -0.4252 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 F24 mock treatment 74440.0 -89700.0 -0.76 32120.0 -113000.0 -0.93 -1.2008 -0.995 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G01 mock treatment 81240.0 -82900.0 -0.71 128960.0 -16100.0 -0.13 -0.5934 -0.8262 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G02 mock treatment 67360.0 -96800.0 -0.82 141600.0 -3500.0 -0.03 -0.603 -0.7315 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G03 compound treatment 111600.0 -52500.0 -0.45 172200.0 27100.0 0.22 -0.1576 -0.3152 3069738 SPBio_002971 CC(C)NCC(O)c1ccc(O)c(O)c1.OC(C(O)C(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G04 compound treatment 124280.0 -39800.0 -0.34 163320.0 18200.0 0.15 -0.1333 -0.359 1327636 SPBio_002972 COc1ccc2c(c1)C(=O)N(CCc3ccc(cc3)S(=O)(=O)NC(=O)NC4CCCCC4)C(=O)C2(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G05 compound treatment 81560.0 -82600.0 -0.7 89840.0 -55300.0 -0.46 -0.8203 -0.9783 1001471 SPBio_002973 Oc1ccc(OCc2ccccc2)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G06 compound treatment 127320.0 -36800.0 -0.31 159200.0 14100.0 0.12 -0.1391 -0.4159 3069778 SPBio_002974 CN1CCC(=C2c3ccsc3CCc4ccccc24)CC1.OC(CC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G07 compound treatment 190680.0 26600.0 0.23 235680.0 90600.0 0.75 0.6898 0.8813 1025776 SPBio_002975 Nc1ccccc1S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G08 compound treatment 178000.0 13900.0 0.12 245920.0 101000.0 0.83 0.6734 0.7993 3188030 SPBio_002976 NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@H](O)C2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G09 compound treatment 154960.0 -9160.0 -0.08 213040.0 67900.0 0.56 0.3423 0.6032 3060043 SPBio_002977 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2CCC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G10 compound treatment 198720.0 34600.0 0.29 244160.0 99100.0 0.82 0.7878 0.9046 1057366 SPBio_002978 NS(=O)(=O)c1cc2c(NC(CC3CCCC3)NS2(=O)=O)cc1Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G11 compound treatment 188720.0 24600.0 0.21 206560.0 61500.0 0.51 0.5076 0.9231 907370 SPBio_002979 CCCCCN(CCCCC)C(=O)C(CCC(=O)O)NC(=O)c1ccc(Cl)c(Cl)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G12 compound treatment 193640.0 29500.0 0.25 230720.0 85600.0 0.71 0.6786 0.9029 3177109 SPBio_002980 COCCCC/C(=N\OCCN)/c1ccc(cc1)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G13 compound treatment 225960.0 61800.0 0.53 235880.0 90800.0 0.75 0.9034 0.9849 117 SPBio_002981 CCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G14 compound treatment 209680.0 45600.0 0.39 221360.0 76300.0 0.63 0.7204 0.9727 3069779 SPBio_002982 NC(=O)c1cc[n+](CC2=C(N3[C@H](SC2)[C@H](NC(=O)Cc4cccs4)C3=O)C(=O)O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G15 compound treatment 186920.0 22800.0 0.19 214080.0 69000.0 0.57 0.5408 0.8972 1000135 SPBio_002983 CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G16 compound treatment 207720.0 43600.0 0.37 216000.0 70900.0 0.59 0.6773 0.9757 1000221 SPBio_002984 CCC(=O)O[C@@]1([C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C)C(=O)SCF 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G17 compound treatment 192080.0 28000.0 0.24 198400.0 53300.0 0.44 0.4801 0.9581 115 SPBio_002985 COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G18 compound treatment 26360.0 -138000.0 -1.17 36320.0 -109000.0 -0.9 -1.4657 -0.9914 3069780 SPBio_002986 OCCN1CCN(CC/C=C\2/c3ccccc3Sc4ccc(Cl)cc24)CC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G19 compound treatment 246160.0 82000.0 0.7 216520.0 71400.0 0.59 0.9117 0.9965 3221506 SPBio_002987 CCC(C)C(N)C1=NC(CS1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H]2CCCCNC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@H](Cc3cnc[nH]3)NC(=O)[C@@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@@H](CCCN)NC2=O)[C@@H](C)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G20 compound treatment 171440.0 7320.0 0.06 202480.0 57400.0 0.47 0.3797 0.7932 4480 SPBio_002988 CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G21 compound treatment 155640.0 -8480.0 -0.07 176200.0 31100.0 0.26 0.1309 0.4898 1008 SPBio_002989 OC1CCCCC1N2CCC(CC2)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G22 compound treatment 178960.0 14800.0 0.13 196840.0 51700.0 0.43 0.392 0.8784 3188032 SPBio_002990 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(=O)NCNC(CCCCN)C(=O)O)C(=O)c4c(O)cccc4[C@@]3(C)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G23 mock treatment 122240.0 -41900.0 -0.36 162200.0 17100.0 0.14 -0.1521 -0.3965 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 G24 mock treatment 72400.0 -91700.0 -0.78 17280.0 -128000.0 -1.06 -1.2999 -0.9889 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H01 mock treatment 105360.0 -58800.0 -0.5 62400.0 -82700.0 -0.68 -0.8375 -0.9882 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H02 mock treatment 102000.0 -62100.0 -0.53 139200.0 -5900.0 -0.05 -0.4085 -0.7691 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H03 compound treatment 133280.0 -30800.0 -0.26 195600.0 50500.0 0.42 0.1098 0.2224 3069853 SPBio_002991 OCN1C(NC(=O)NCNC(=O)NC2N(CO)C(=O)NC2=O)C(=O)NC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H04 mock treatment 210720.0 46600.0 0.4 209280.0 64200.0 0.53 0.656 0.9897 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H05 compound treatment 178920.0 14800.0 0.13 172080.0 27000.0 0.22 0.247 0.9634 1503 SPBio_002992 Cc1c(CS(=O)c2nc3ccccc3[nH]2)nccc1OCC(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H06 mock treatment 244000.0 79900.0 0.68 217080.0 72000.0 0.6 0.902 0.9978 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H07 compound treatment 209040.0 44900.0 0.38 236360.0 91300.0 0.75 0.8043 0.9503 834 SPBio_002993 CC(C[N+](C)(C)C)OC(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H08 mock treatment 192480.0 28400.0 0.24 233680.0 88600.0 0.73 0.6889 0.8929 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H09 compound treatment 164720.0 602.0 0.01 180280.0 35200.0 0.29 0.2094 0.7194 3188277 SPBio_002994 CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(Cl)C4=CC(=O)C5CC5[C@]4(C)[C@H]3CC[C@@]21C)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H10 mock treatment 247840.0 83700.0 0.71 235520.0 90400.0 0.75 1.033 0.9997 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H11 compound treatment 215240.0 51100.0 0.44 240760.0 95700.0 0.79 0.8674 0.9603 1000206 SPBio_002995 CC(C)NC[C@@H](O)COc1cccc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H12 mock treatment 236120.0 72000.0 0.61 310320.0 165000.0 1.37 1.4 0.9346 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H13 compound treatment 253520.0 89400.0 0.76 245840.0 101000.0 0.83 1.1276 0.999 3903 SPBio_002996 CC(C)(Oc1ccc(cc1)C2CC2(Cl)Cl)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H14 mock treatment 266240.0 102000.0 0.87 213560.0 68500.0 0.57 1.0153 0.9784 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H15 compound treatment 252440.0 88300.0 0.75 225920.0 80800.0 0.67 1.0045 0.9983 1029881 SPBio_002997 CN1C2CCC1CC(O)C2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H16 mock treatment 242520.0 78400.0 0.67 193560.0 48500.0 0.4 0.7555 0.9702 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H17 compound treatment 220880.0 56800.0 0.48 212840.0 67700.0 0.56 0.738 0.9973 954 SPBio_002998 CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H18 mock treatment 222560.0 58400.0 0.5 210560.0 65500.0 0.54 0.7348 0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H19 compound treatment 197600.0 33500.0 0.29 198000.0 52900.0 0.44 0.511 0.9784 1295 SPBio_002999 OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H20 mock treatment 218520.0 54400.0 0.46 199560.0 54500.0 0.45 0.6461 0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H21 compound treatment 127720.0 -36400.0 -0.31 126840.0 -18300.0 -0.15 -0.3259 -0.9454 3188278 SPBio_003000 COC(=O)Nc1nc2cc(SC(C)C)ccc2[nH]1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H22 mock treatment 181160.0 17000.0 0.15 178280.0 33200.0 0.27 0.2967 0.9556 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H23 mock treatment 119320.0 -44800.0 -0.38 135320.0 -9780.0 -0.08 -0.3269 -0.8384 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 H24 mock treatment 76120.0 -88000.0 -0.75 30000.0 -115000.0 -0.95 -1.2031 -0.993 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I01 mock treatment 119520.0 -44600.0 -0.38 54200.0 -90900.0 -0.75 -0.8002 -0.9499 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I02 mock treatment 142280.0 -21800.0 -0.19 109400.0 -35700.0 -0.3 -0.3403 -0.9751 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I03 compound treatment 157560.0 -6560.0 -0.06 170120.0 25000.0 0.21 0.1069 0.4985 3188016 SPBio_003001 CN/C(=C\[N+](=O)[O-])/NCCSCc1csc(CN(C)C)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I04 compound treatment 172000.0 7880.0 0.07 202040.0 56900.0 0.47 0.3805 0.7998 3069781 SPBio_003002 CC(=O)OCC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I05 compound treatment 156440.0 -7680.0 -0.07 165480.0 20400.0 0.17 0.073 0.4037 3188017 SPBio_003003 S=C(NC1CCCCC1)N2CCC(CC2)C3C=NC=N3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I06 compound treatment 207040.0 42900.0 0.37 223000.0 77900.0 0.64 0.7141 0.9639 3177333 SPBio_003004 CC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4C[C@H](O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I07 compound treatment 217000.0 52900.0 0.45 200840.0 55700.0 0.46 0.6444 0.9999 3061617 SPBio_003005 OC(CNCCNC(=O)N1CCOCC1)COc2ccc(O)cc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I08 compound treatment 234640.0 70500.0 0.6 208320.0 63200.0 0.52 0.7944 0.9976 1053328 SPBio_003006 CCCC1C(=O)N2N(C1=O)c3cc(C)ccc3N=C2N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I09 compound treatment 229400.0 65300.0 0.56 197560.0 52500.0 0.43 0.6999 0.9925 1000092 SPBio_003007 COc1ccc(cc1OC2CCCC2)C3CNC(=O)C3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I10 compound treatment 207400.0 43300.0 0.37 209680.0 64600.0 0.53 0.6384 0.9836 3188033 SPBio_003008 CCC1(CCCCN(C)C1)c2cccc(O)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I11 compound treatment 21680.0 -142000.0 -1.21 23160.0 -122000.0 -1.01 -1.5708 -0.9958 1007994 SPBio_003009 CCCCCCCCCCCCCCCC[N+](C)(C)CCN(Cc1ccc(OC)cc1)c2ncccn2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I12 compound treatment 271080.0 107000.0 0.91 228720.0 83600.0 0.69 1.1331 0.9908 3188034 SPBio_003010 CNC1C(O)C2O[C@H](OC3C(N)C[C@@H](N)C(O)[C@H]3O)C(N)C[C@@H]2O[C@@H]1O[C@H]4OC(CO)[C@@H](N)[C@H](O)C4O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I13 compound treatment 217120.0 53000.0 0.45 214280.0 69200.0 0.57 0.7238 0.9931 3060036 SPBio_003011 C1CN=C(N1)C2COc3ccccc3O2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I14 compound treatment 222480.0 58400.0 0.5 235840.0 90700.0 0.75 0.8822 0.9799 3069782 SPBio_003012 C[C@@]12CC[C@H]3[C@@H](CC[C@H]4CC5SC5C[C@@]43C)[C@@H]2CC[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I15 compound treatment 241640.0 77500.0 0.66 194240.0 49100.0 0.41 0.7542 0.9729 3188018 SPBio_003013 CCN(CC)C(=O)N[C@@H]1CC2C(Cc3c[nH]c4cccc2c34)N(C)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I16 compound treatment 208840.0 44700.0 0.38 146320.0 1220.0 0.01 0.2764 0.7256 3188035 SPBio_003014 C/C(=C(/CCO)\SSCC1CCCO1)/N(Cc2cnc(C)nc2N)C=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I17 compound treatment 234440.0 70300.0 0.6 189920.0 44800.0 0.37 0.6856 0.9735 1765 SPBio_003015 CC1(C)NC(=O)N(C1=O)c2ccc([N+](=O)[O-])c(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I18 compound treatment 219160.0 55000.0 0.47 204800.0 59700.0 0.49 0.6806 0.9997 2080 SPBio_003016 CCOC(=O)c1ccc(OC(=O)CCCCCNC(=N)N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I19 compound treatment 206040.0 41900.0 0.36 208800.0 63700.0 0.53 0.625 0.982 3172846 SPBio_003017 NC(CO)(CO)CO.OC(=O)C1CCn2c(ccc12)C(=O)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I20 compound treatment 169640.0 5520.0 0.05 203320.0 58200.0 0.48 0.3738 0.7725 3188145 SPBio_003018 CC(C)(C)C(=O)OCOC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](NC(=O)[C@H](N)c3ccccc3)C2=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I21 compound treatment 169720.0 5600.0 0.05 137720.0 -7380.0 -0.06 -0.0094 -0.1218 4487 SPBio_003019 CNCCCC1c2ccccc2C=Cc3ccccc13 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I22 compound treatment 151720.0 -12400.0 -0.11 137640.0 -7460.0 -0.06 -0.1183 -0.9673 3188146 SPBio_003020 CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C(=O)OC4OC(=O)c5ccccc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I23 mock treatment 119120.0 -45000.0 -0.38 131720.0 -13400.0 -0.11 -0.3492 -0.8756 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 I24 mock treatment 88000.0 -76100.0 -0.65 28640.0 -116000.0 -0.96 -1.1395 -0.9814 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J01 mock treatment 163600.0 -518.0 0.0 45920.0 -99200.0 -0.82 -0.5833 -0.7109 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J02 mock treatment 149400.0 -14700.0 -0.13 126160.0 -18900.0 -0.16 -0.1994 -0.9939 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J03 compound treatment 181400.0 17300.0 0.15 143000.0 -2100.0 -0.02 0.0918 0.6194 3002368 SPBio_003021 CC(C)NC[C@H](O)COc1cccc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J04 mock treatment 196640.0 32500.0 0.28 190200.0 45100.0 0.37 0.4596 0.9892 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J05 compound treatment 95360.0 -68800.0 -0.59 82760.0 -62300.0 -0.52 -0.7786 -0.998 907302 SPBio_003022 CN1CC[C@]2(C)C1N(C)c3ccc(O)cc32 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J06 mock treatment 225280.0 61200.0 0.52 228760.0 83700.0 0.69 0.8576 0.9902 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J07 compound treatment 227560.0 63400.0 0.54 216520.0 71400.0 0.59 0.7997 0.999 3188279 SPBio_003023 CCN1C[C@]2(COC)CC[C@H](O)C3(C4C[C@H]5[C@H](OC(=O)C)C4[C@](O)(CC5OC)[C@H]6CC32)[C@@H]61 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J08 mock treatment 232920.0 68800.0 0.59 197400.0 52300.0 0.43 0.7202 0.9889 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J09 compound treatment 233840.0 69700.0 0.59 202960.0 57900.0 0.48 0.7582 0.9943 2060476 SPBio_003024 C[C@H]1[C@@H]2CCC(=C3[C@@H]([C@H]2OC1=O)C(=CC3=O)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J10 mock treatment 237040.0 72900.0 0.62 226440.0 81300.0 0.67 0.9149 0.9992 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J11 compound treatment 239320.0 75200.0 0.64 285320.0 140000.0 1.16 1.273 0.9608 1336284 SPBio_003025 COc1c2CC(Oc2nc3ccccc13)C(C)(O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J12 mock treatment 252840.0 88700.0 0.76 224240.0 79100.0 0.65 0.9971 0.9975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J13 compound treatment 240480.0 76400.0 0.65 238120.0 93000.0 0.77 1.0039 0.9965 3176921 SPBio_003026 N[C@H]1CONC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J14 mock treatment 265520.0 101000.0 0.86 200560.0 55500.0 0.46 0.9349 0.9562 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J15 compound treatment 244360.0 80200.0 0.68 197520.0 52400.0 0.43 0.7897 0.9759 3069855 SPBio_003027 Clc1cnccn1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J16 mock treatment 251160.0 87000.0 0.74 209960.0 64900.0 0.54 0.9035 0.9874 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J17 compound treatment 194920.0 30800.0 0.26 155600.0 10500.0 0.09 0.2469 0.8936 1076620 SPBio_003028 CNCC(O)c1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J18 mock treatment 244720.0 80600.0 0.69 186520.0 41400.0 0.34 0.7276 0.9485 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J19 compound treatment 199640.0 35500.0 0.3 194760.0 49700.0 0.41 0.5044 0.9886 760 SPBio_003029 N[C@@H]1CONC1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J20 mock treatment 232200.0 68100.0 0.58 198040.0 52900.0 0.44 0.7196 0.9904 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J21 compound treatment 205400.0 41300.0 0.35 163880.0 18800.0 0.16 0.3584 0.9326 1076027 SPBio_003030 CC1CC(CC(C)(C)C1)OC(=O)c2ccccc2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J22 mock treatment 163680.0 -438.0 0.0 138040.0 -7060.0 -0.06 -0.0439 -0.7507 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J23 mock treatment 175960.0 11800.0 0.1 145480.0 382.0 0.0 0.0735 0.7289 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 J24 mock treatment 132040.0 -32100.0 -0.27 61880.0 -83200.0 -0.69 -0.6799 -0.918 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K01 mock treatment 193080.0 29000.0 0.25 41360.0 -104000.0 -0.86 -0.4325 -0.4843 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K02 mock treatment 178720.0 14600.0 0.12 123520.0 -21600.0 -0.18 -0.0383 -0.1761 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K03 compound treatment 150600.0 -13500.0 -0.12 102000.0 -43100.0 -0.36 -0.3335 -0.8901 1677 SPBio_003031 CC(C)c1cccc(C(C)C)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K04 compound treatment 211560.0 47400.0 0.4 203600.0 58500.0 0.48 0.6278 0.996 3188147 SPBio_003032 Cc1onc(c1C(=O)N[C@H]2[C@H]3SC(C)(C)C(N3C2=O)C(=O)O)c4c(F)cccc4Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K05 compound treatment 70280.0 -93800.0 -0.8 59240.0 -85900.0 -0.71 -1.0672 -0.9983 3188019 SPBio_003033 CCN1CCCC1CNC(=O)c2c(O)c(CC)cc(Cl)c2OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K06 compound treatment 296120.0 132000.0 1.12 223400.0 78300.0 0.65 1.2528 0.9657 2920 SPBio_003034 CCN(CC)c1cc(C)nc2ncnn12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K07 compound treatment 273680.0 110000.0 0.93 192080.0 47000.0 0.39 0.9344 0.9247 962 SPBio_003035 CCC1(C(=O)NCNC1=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K08 compound treatment 105080.0 -59000.0 -0.5 64320.0 -80800.0 -0.67 -0.828 -0.9901 3188148 SPBio_003036 CN1C2CCC1CC(C2)OC3c4ccccc4CCc5ccccc35 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K09 compound treatment 359800.0 196000.0 1.67 181840.0 36700.0 0.3 1.393 0.8225 1910 SPBio_003037 Nc1nc(=O)[nH]cc1F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K10 compound treatment 50760.0 -113000.0 -0.97 38040.0 -107000.0 -0.89 -1.3087 -0.9991 3069806 SPBio_003038 OCCOCCOC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K11 compound treatment 258280.0 94200.0 0.8 178000.0 32900.0 0.27 0.7594 0.8969 3069740 SPBio_003039 C[C@]1(N[C@H]2Cc3ccccc31)c4ccccc24 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K12 compound treatment 277480.0 113000.0 0.97 212480.0 67400.0 0.56 1.0767 0.966 1022844 SPBio_003040 Oc1ccc(O)c(c1)S(=O)(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K13 compound treatment 278040.0 114000.0 0.97 233800.0 88700.0 0.73 1.2047 0.9905 3188020 SPBio_003041 C[N+](C)(CCCOc1ccccc1)c2ccccc2.OC(=O)c1cc2ccccc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K14 compound treatment 247680.0 83600.0 0.71 173920.0 28800.0 0.24 0.6717 0.8951 1779 SPBio_003042 COc1nc(C)nc(Cl)c1NC2=NCCN2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K15 compound treatment 73840.0 -90300.0 -0.77 55840.0 -89300.0 -0.74 -1.0657 -0.9998 3069741 SPBio_003043 CC(=O)O[C@H]1CC[C@]2(C)[C@H]3CC[C@@]4(C)[C@@H](CCC4=O)[C@@H]3CC=C2C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K16 compound treatment 320200.0 156000.0 1.33 184320.0 39200.0 0.32 1.1691 0.8546 1326779 SPBio_003044 CCNCC(O)c1cccc(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K17 compound treatment 227160.0 63000.0 0.54 146520.0 1420.0 0.01 0.3879 0.7224 1095 SPBio_003045 NC(CO)C(=O)NNCc1ccc(O)c(O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K18 compound treatment 233840.0 69700.0 0.59 196720.0 51600.0 0.43 0.7217 0.9869 220 SPBio_003046 CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K19 compound treatment 274240.0 110000.0 0.94 197880.0 52800.0 0.44 0.9717 0.9395 2685 SPBio_003047 OC(=O)c1c(I)cc(I)c(NC(=O)CCCCC(=O)Nc2c(I)cc(I)c(C(=O)O)c2I)c1I 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K20 compound treatment 228200.0 64100.0 0.55 150040.0 4940.0 0.04 0.4147 0.758 3188149 SPBio_003048 CCO[C@@H]1O[C@H](C(COCc2ccccc2)OCc3ccccc3)[C@@H](OCc4ccccc4)C1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K21 compound treatment 198880.0 34800.0 0.3 136760.0 -8340.0 -0.07 0.1605 0.5282 1020463 SPBio_003049 Oc1cc2ccc(=O)oc2cc1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K22 compound treatment 145080.0 -19000.0 -0.16 95440.0 -49700.0 -0.41 -0.4051 -0.9173 3188150 SPBio_003050 CCC(=O)[C@@]1(C)[C@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K23 mock treatment 135760.0 -28400.0 -0.24 110440.0 -34700.0 -0.29 -0.3735 -0.9963 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 K24 mock treatment 164040.0 -78.1 0.0 38880.0 -106000.0 -0.88 -0.6218 -0.7076 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L01 mock treatment 183480.0 19400.0 0.16 43400.0 -102000.0 -0.84 -0.4783 -0.5579 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L02 mock treatment 169040.0 4920.0 0.04 120800.0 -24300.0 -0.2 -0.1125 -0.5479 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L03 compound treatment 170160.0 6040.0 0.05 134720.0 -10400.0 -0.09 -0.0243 -0.2431 1269 SPBio_003051 CC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L04 mock treatment 215160.0 51000.0 0.43 133400.0 -11700.0 -0.1 0.2389 0.5365 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L05 compound treatment 264280.0 100000.0 0.85 155440.0 10300.0 0.09 0.6635 0.7742 3069858 SPBio_003052 Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(=O)(O)O[C@@H]4C3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L06 mock treatment 241080.0 77000.0 0.66 200840.0 55700.0 0.46 0.7894 0.9852 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L07 compound treatment 224640.0 60500.0 0.52 165840.0 20700.0 0.17 0.4857 0.8943 907479 SPBio_003053 CCCN1CCC[C@@H]2Cc3n[nH]cc3C[C@H]21 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L08 mock treatment 281680.0 118000.0 1.0 191000.0 45900.0 0.38 0.9763 0.9119 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L09 compound treatment 247840.0 83700.0 0.71 149320.0 4220.0 0.03 0.5287 0.7409 3188280 SPBio_003054 COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L10 mock treatment 276160.0 112000.0 0.95 198160.0 53100.0 0.44 0.9849 0.9379 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L11 compound treatment 259200.0 95100.0 0.81 209720.0 64600.0 0.53 0.9505 0.9797 1221 SPBio_003055 CN(C)CCOC(=O)C(c1ccccc1)C2(O)CCCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L12 mock treatment 241440.0 77300.0 0.66 248240.0 103000.0 0.85 1.0689 0.9918 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L13 compound treatment 239200.0 75100.0 0.64 225480.0 80400.0 0.66 0.9222 0.9998 3188281 SPBio_003056 C[C@@]12CC[C@H]3[C@@H](CCc4cc(O)ccc34)[C@@H]2C[C@@H](O)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L14 mock treatment 277840.0 114000.0 0.97 180960.0 35900.0 0.3 0.8944 0.8832 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L15 compound treatment 231760.0 67600.0 0.58 124720.0 -20400.0 -0.17 0.288 0.48 1479 SPBio_003057 CC(C)NCC(O)c1ccc(O)c(O)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L16 mock treatment 258040.0 93900.0 0.8 148360.0 3260.0 0.03 0.5845 0.7306 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L17 compound treatment 182200.0 18100.0 0.15 115160.0 -29900.0 -0.25 -0.0663 -0.2272 2121 SPBio_003058 Oc1ccc(cc1)c2oc3cc(O)cc(O)c3c(=O)c2O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L18 mock treatment 292800.0 129000.0 1.1 121800.0 -23300.0 -0.19 0.6384 0.5739 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L19 compound treatment 213800.0 49700.0 0.42 183720.0 38600.0 0.32 0.525 0.9904 865102 SPBio_003059 O=C(CCNNC(=O)c1ccncc1)NCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L20 mock treatment 262320.0 98200.0 0.84 146000.0 902.0 0.01 0.5965 0.7134 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L21 compound treatment 24440.0 -140000.0 -1.19 12160.0 -133000.0 -1.1 -1.6186 -0.9992 3188282 SPBio_003060 CC1C(C/C=C(\C)/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)C(=O)c2ccccc2C1=O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L22 mock treatment 157840.0 -6280.0 -0.05 80240.0 -64900.0 -0.54 -0.4172 -0.7737 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L23 mock treatment 183680.0 19600.0 0.17 105600.0 -39500.0 -0.33 -0.1133 -0.3089 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 L24 mock treatment 159920.0 -4200.0 -0.04 43160.0 -102000.0 -0.84 -0.6216 -0.7364 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M01 mock treatment 172440.0 8320.0 0.07 39160.0 -106000.0 -0.88 -0.5696 -0.6478 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M02 mock treatment 170640.0 6520.0 0.06 93880.0 -51200.0 -0.42 -0.2603 -0.6092 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M03 compound treatment 165520.0 1400.0 0.01 89680.0 -55400.0 -0.46 -0.3157 -0.6885 2030 SPBio_003061 OC(=O)CN(CCN(CC(=O)O)CC(=O)O)CCN(CC(=O)O)CC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M04 compound treatment 192480.0 28400.0 0.24 103440.0 -41700.0 -0.34 -0.0729 -0.1733 3480040 SPBio_003062 COC(=O)C1=C(C)NC(=C(C1c2cccc3nonc23)C(=O)OC(C)C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M05 compound treatment 199080.0 35000.0 0.3 124280.0 -20800.0 -0.17 0.0887 0.2579 907192 SPBio_003063 CC[N+](C)(C)Cc1ccccc1Br 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M06 compound treatment 203840.0 39700.0 0.34 104720.0 -40400.0 -0.33 0.0029 0.0062 1077199 SPBio_003064 CCNC1(CCCCC1=O)c2cccs2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M07 compound treatment 225000.0 60900.0 0.52 105720.0 -39400.0 -0.33 0.1362 0.2225 3172714 SPBio_003065 C[n+]1ccccc1/C=N/O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M08 compound treatment 235960.0 71800.0 0.61 91960.0 -53100.0 -0.44 0.1217 0.1615 3069807 SPBio_003066 CNC(C)CCC=C(C)C.OC(C(O)C(O)C(=O)O)C(O)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M09 compound treatment 173400.0 9280.0 0.08 70480.0 -74600.0 -0.62 -0.3806 -0.6116 1395 SPBio_003067 CC(COc1ccccc1)N(CCCl)Cc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M10 compound treatment 247920.0 83800.0 0.71 133840.0 -11300.0 -0.09 0.4387 0.6096 3188151 SPBio_003068 CC1CS(=O)(=O)CCN1/N=C/c2ccc(o2)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M11 compound treatment 232160.0 68000.0 0.58 155840.0 10700.0 0.09 0.4725 0.8061 2844 SPBio_003069 CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M12 compound treatment 244240.0 80100.0 0.68 186240.0 41100.0 0.34 0.723 0.9484 1698 SPBio_003070 N#Cc1ccc(cc1)C(c2ccc(C#N)cc2)n3cncn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M13 compound treatment 244240.0 80100.0 0.68 195800.0 50700.0 0.42 0.779 0.9727 1371 SPBio_003071 CN(C)c1nc(nc(n1)N(C)C)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M14 compound treatment 243880.0 79800.0 0.68 124440.0 -20700.0 -0.17 0.3594 0.5132 4425 SPBio_003072 CC(C)NCC1CCc2cc(CO)c(cc2N1)[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M15 compound treatment 201280.0 37200.0 0.32 71680.0 -73400.0 -0.61 -0.2057 -0.3004 349 SPBio_003073 COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M16 compound treatment 219520.0 55400.0 0.47 68960.0 -76100.0 -0.63 -0.1118 -0.1421 3188152 SPBio_003074 CC(N)C(=O)Nc1c(C)cccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M17 compound treatment 238440.0 74300.0 0.63 93920.0 -51200.0 -0.42 0.1481 0.1945 1428570 SPBio_003075 CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M18 compound treatment 250920.0 86800.0 0.74 89680.0 -55400.0 -0.46 0.1984 0.2281 3188153 SPBio_003076 CC1(C)S[C@@H]2[C@H](NC(=O)COc3ccccc3)C(=O)N2C1C(=O)O.C(CNCc1ccccc1)NCc2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M19 compound treatment 199320.0 35200.0 0.3 127720.0 -17400.0 -0.14 0.1103 0.3317 893 SPBio_003077 NCC(O)c1ccc(O)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M20 compound treatment 143320.0 -20800.0 -0.18 86240.0 -58900.0 -0.49 -0.4695 -0.9062 1795 SPBio_003078 Cc1nc2CCCCn2c(=O)c1CCN3CCC(CC3)c4noc5cc(F)ccc45 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M21 compound treatment 232640.0 68500.0 0.58 111640.0 -33500.0 -0.28 0.2168 0.3358 806 SPBio_003079 OC(=O)C1CCCNC1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M22 compound treatment 183120.0 19000.0 0.16 75440.0 -69700.0 -0.58 -0.2931 -0.4897 1001638 SPBio_003080 CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M23 mock treatment 132920.0 -31200.0 -0.27 76320.0 -68800.0 -0.57 -0.5902 -0.9398 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 M24 mock treatment 128840.0 -35300.0 -0.3 38520.0 -107000.0 -0.88 -0.8358 -0.8974 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N01 mock treatment 177520.0 13400.0 0.11 49680.0 -95400.0 -0.79 -0.4775 -0.5987 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N02 mock treatment 206440.0 42300.0 0.36 103280.0 -41800.0 -0.35 0.0102 0.0204 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N03 compound treatment 188080.0 24000.0 0.2 79840.0 -65300.0 -0.54 -0.2375 -0.4115 3487604 SPBio_003081 CCNC1CC(N)C(OC2OC(=CCC2N)CN)C(O)C1OC3OCC(C)(O)C(NC)C3O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N04 mock treatment 208760.0 44600.0 0.38 95680.0 -49400.0 -0.41 -0.0203 -0.0364 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N05 compound treatment 212120.0 48000.0 0.41 94280.0 -50800.0 -0.42 -0.0083 -0.0141 3173761 SPBio_003082 N[C@@H](C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)Cl)c3ccccc3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N06 mock treatment 233560.0 69400.0 0.59 110480.0 -34600.0 -0.29 0.2156 0.3281 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N07 compound treatment 241440.0 77300.0 0.66 88240.0 -56900.0 -0.47 0.1329 0.1643 1111897 SPBio_003083 COc1ccc2nccc(C(=O)O)c2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N08 mock treatment 247720.0 83600.0 0.71 75040.0 -70100.0 -0.58 0.0935 0.1019 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N09 compound treatment 229920.0 65800.0 0.56 102800.0 -42300.0 -0.35 0.1487 0.2252 3188283 SPBio_003084 CC1O[C@@H](OC/2C[C@@H]3O[C@@](O)(C[C@H](O)[C@H]3C(=O)O)C[C@@H](O)C[C@H]4O[C@@H]4\C=C\C(=O)O[C@H](C)C\C=C\C=C\C=C\C=C2)C(O)C(N)[C@@H]1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N10 mock treatment 234320.0 70200.0 0.6 103360.0 -41700.0 -0.35 0.1785 0.2586 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N11 compound treatment 23320.0 -141000.0 -1.2 11800.0 -133000.0 -1.1 -1.6274 -0.9991 3188284 SPBio_003085 COC(=O)CCc1c(C)c2cc3[nH]c(cc4nc(cc5[nH]c(cc1n2)c(CCC(=O)O)c5C)[C@]6(C)C(C(=O)OC)C(=CC=C46)C(=O)OC)c(C)c3C=C.COC(=O)CCc1c(C)c2cc3nc(cc4[nH]c(cc5nc(cc1[nH]2)c(CCC(=O)O)c5C)c(C=C)c4C)C6=CC=C(C(C(=O)OC)[C@]63C)C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N12 mock treatment 226320.0 62200.0 0.53 188320.0 43200.0 0.36 0.6273 0.9817 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N13 compound treatment 237920.0 73800.0 0.63 196640.0 51500.0 0.43 0.7458 0.9822 1000348 SPBio_003086 C[C@@H](O)[C@@H]1[C@H]2[C@@H](C)C(=C(N2C1=O)C(=O)O)S[C@@H]3CN[C@@H](C3)C(=O)N(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N14 mock treatment 237920.0 73800.0 0.63 145880.0 782.0 0.01 0.4489 0.7143 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N15 compound treatment 243840.0 79700.0 0.68 101320.0 -43800.0 -0.36 0.2239 0.291 3069861 SPBio_003087 CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2C(C[C@@H]3CCC[C@@H]32)C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N16 mock treatment 261400.0 97300.0 0.83 80800.0 -64300.0 -0.53 0.2096 0.2129 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N17 compound treatment 222000.0 57900.0 0.49 55080.0 -90000.0 -0.74 -0.1781 -0.1994 1517 SPBio_003088 CCC1(NC(=O)N(C)C1=O)c2ccccc2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N18 mock treatment 238240.0 74100.0 0.63 68720.0 -76400.0 -0.63 -5.0E-4 -6.0E-4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N19 compound treatment 229200.0 65100.0 0.55 93880.0 -51200.0 -0.42 0.0922 0.1322 3188285 SPBio_003089 CO[C@H]1/C=C/O[C@@]2(C)Oc3c(C2=O)c4C5=NC6(CCN(CC(C)C)CC6)NC5=C(NC(=O)/C(=C\C=C\[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(=O)C)[C@@H]1C)/C)C(=O)c4c(O)c3C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N20 mock treatment 219920.0 55800.0 0.48 114520.0 -30600.0 -0.25 0.1571 0.2918 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N21 compound treatment 138760.0 -25400.0 -0.22 97600.0 -47500.0 -0.39 -0.4305 -0.9602 3069862 SPBio_003090 CCCCc1ccc2[nH]c(NC(=O)OC)nc2c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N22 mock treatment 167880.0 3760.0 0.03 86080.0 -59000.0 -0.49 -0.3226 -0.6593 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N23 mock treatment 147400.0 -16700.0 -0.14 56760.0 -88300.0 -0.73 -0.6174 -0.8293 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 N24 mock treatment 151040.0 -13100.0 -0.11 66920.0 -78200.0 -0.65 -0.5361 -0.8168 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O01 mock treatment 94760.0 -69400.0 -0.59 64600.0 -80500.0 -0.67 -0.8885 -0.9982 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O02 mock treatment 184520.0 20400.0 0.17 89280.0 -55800.0 -0.46 -0.2037 -0.4129 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O03 compound treatment 196160.0 32000.0 0.27 60320.0 -84800.0 -0.7 -0.303 -0.4027 2660 SPBio_003091 CCN(C(=O)/C=C/C)c1ccccc1C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O04 compound treatment 184280.0 20200.0 0.17 34920.0 -110000.0 -0.91 -0.5231 -0.564 2080909 SPBio_003092 CCCCN(CCCC)CCC(O)c1cc2c(Cl)cc(Cl)cc2c3cc(ccc13)C(F)(F)F 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O05 compound treatment 226520.0 62400.0 0.53 68520.0 -76600.0 -0.63 -0.0723 -0.0874 351 SPBio_003093 CC(C)NCC(O)COc1cccc2ccccc12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O06 compound treatment 233960.0 69800.0 0.59 64600.0 -80500.0 -0.67 -0.0504 -0.0565 3069809 SPBio_003094 CCCNC(C)C(=O)Nc1c(C)csc1C(=O)OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O07 compound treatment 219520.0 55400.0 0.47 52600.0 -92500.0 -0.77 -0.2075 -0.2309 1001857 SPBio_003095 CC(C)NC[C@@H](O)COc1ccc(CC(=O)N)cc1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O08 compound treatment 224160.0 60000.0 0.51 36800.0 -108000.0 -0.9 -0.272 -0.2637 3188154 SPBio_003096 CC(=O)CC(=O)[C@@]1(O)CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O09 compound treatment 225960.0 61800.0 0.53 20800.0 -124000.0 -1.03 -0.3548 -0.3071 3188022 SPBio_003097 CC(C)(C)CC(C)(C)c1ccc(OCOCCOCCO)c(Cc2cc(cc(Cc3cc(ccc3OCOCCOCCO)C(C)(C)CC(C)(C)C)c2OCOCCOCCO)C(C)(C)CC(C)(C)C)c1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O10 compound treatment 275680.0 112000.0 0.95 75120.0 -70000.0 -0.58 0.2623 0.2358 3177327 SPBio_003098 CC(=O)O[C@H]1[C@H](C[C@H]2[C@@H]3CC[C@H]4C[C@H](OC(=O)C)[C@H](C[C@]4(C)[C@H]3CC[C@]12C)[N+]5(C)CCCCC5)[N+]6(C)CCCCC6 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O11 compound treatment 277000.0 113000.0 0.96 98480.0 -46600.0 -0.39 0.4069 0.3929 3069742 SPBio_003099 CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O12 compound treatment 280560.0 116000.0 0.99 191400.0 46300.0 0.38 0.9719 0.9144 1511611 SPBio_003100 CCc1c(C)[nH]c2CCC(CN3CCOCC3)C(=O)c12 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O13 compound treatment 212160.0 48000.0 0.41 154240.0 9140.0 0.08 0.3427 0.8239 4369 SPBio_003101 CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@]4(C)[C@H]3CC[C@@]21C)C(=O)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O14 compound treatment 304120.0 140000.0 1.19 148720.0 3620.0 0.03 0.8641 0.7247 3188155 SPBio_003102 OC/C=C\1/[C@@H]2C[C@@H]3[C@@H](CC[C@]34C5N(C=C6C7N(C=C52)c8ccccc8[C@]97CC[C@@H]%10[C@H]9C[C@H]6\C(=C\CO)\N%10CC=C)c%11ccccc%114)N1CC=C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O15 compound treatment 198640.0 34500.0 0.29 51240.0 -93900.0 -0.78 -0.3412 -0.411 3069771 SPBio_003103 C[C@@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]2CC[C@@H]1C(=O)CO 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O16 compound treatment 342600.0 178000.0 1.52 49040.0 -96100.0 -0.79 0.5126 0.2989 2747 SPBio_003104 Nc1ccn([C@H]2CC[C@@H](CO)O2)c(=O)n1 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O17 compound treatment 260440.0 96300.0 0.82 45960.0 -99100.0 -0.82 0.0 0.0 1000212 SPBio_003105 C[C@H](CCC(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O18 compound treatment 204760.0 40600.0 0.35 33960.0 -111000.0 -0.92 -0.4054 -0.4127 3069810 SPBio_003106 COc1ccc(C[C@](C)(N)C(=O)O)cc1OC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O19 compound treatment 113880.0 -50200.0 -0.43 51960.0 -93100.0 -0.77 -0.8473 -0.9614 4481 SPBio_003107 CCCOc1ccc(cc1N)C(=O)OCCN(CC)CC 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O20 compound treatment 259240.0 95100.0 0.81 85920.0 -59200.0 -0.49 0.2265 0.2393 3069811 SPBio_003108 C[C@@H]1CN(CC[C@]1(C(=O)O)c2ccccc2)[C@H]3CC[C@](CC3)(C#N)c4ccc(F)cc4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O21 compound treatment 243960.0 79800.0 0.68 99600.0 -45500.0 -0.38 0.2145 0.2761 1167 SPBio_003109 NCCCCCC(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O22 compound treatment 18320.0 -146000.0 -1.24 7880.0 -137000.0 -1.14 -1.6805 -0.999 3188156 SPBio_003110 CN(C)c1ccc2[n+](C)c(/C=C\c3cc(C)n(c3C)c4ccccc4)ccc2c1.OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O23 mock treatment 190600.0 26500.0 0.23 65840.0 -79300.0 -0.66 -0.3042 -0.4387 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 O24 mock treatment 137800.0 -26300.0 -0.22 50680.0 -94400.0 -0.78 -0.7108 -0.8747 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P01 mock treatment 55960.0 -108000.0 -0.92 87040.0 -58100.0 -0.48 -0.9908 -0.954 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P02 mock treatment 92400.0 -71700.0 -0.61 90440.0 -54700.0 -0.45 -0.7515 -0.9891 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P03 compound treatment 116800.0 -47300.0 -0.4 86800.0 -58300.0 -0.48 -0.6259 -0.996 3856 SPBio_003111 CNC1(C)C2CCC(C2)C1(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P04 mock treatment 147760.0 -16400.0 -0.14 54440.0 -90700.0 -0.75 -0.6288 -0.8243 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P05 compound treatment 183360.0 19200.0 0.16 40760.0 -104000.0 -0.86 -0.4945 -0.5628 3199 SPBio_003112 CNNCc1ccc(cc1)C(=O)NC(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P06 mock treatment 308400.0 144000.0 1.23 55680.0 -89400.0 -0.74 0.3456 0.241 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P07 compound treatment 271680.0 108000.0 0.92 42920.0 -102000.0 -0.85 0.0499 0.04 3188286 SPBio_003113 NCCCC(N)CC(=O)NC1CNC(=O)C(NC(=O)/C(=C/NC(=O)N)/NC(=O)C(CO)NC(=O)C(CO)NC1=O)C2CC(O)N=C(N)N2 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P08 mock treatment 266840.0 103000.0 0.87 52800.0 -92300.0 -0.76 0.0785 0.0676 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P09 compound treatment 223360.0 59200.0 0.5 46080.0 -99000.0 -0.82 -0.2226 -0.2314 3069863 SPBio_003114 CC(C)(C)NC(=O)[C@@H]1C[C@@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc3ccccc3)NC(=O)[C@H](CC(=O)N)NC(=O)c4ccc5ccccc5n4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P10 mock treatment 275720.0 112000.0 0.95 45720.0 -99400.0 -0.82 0.0906 0.0721 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P11 compound treatment 325440.0 161000.0 1.37 58400.0 -86700.0 -0.72 0.4641 0.2995 1509 SPBio_003115 Cn1c(COC(=O)N)ncc1[N+](=O)[O-] 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P12 mock treatment 285400.0 121000.0 1.03 152240.0 7140.0 0.06 0.772 0.7463 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P13 compound treatment 272400.0 108000.0 0.92 148600.0 3500.0 0.03 0.6724 0.729 1829 SPBio_003116 CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(=O)(=O)N 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P14 mock treatment 262520.0 98400.0 0.84 90320.0 -54800.0 -0.45 0.272 0.2856 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P15 compound treatment 137400.0 -26700.0 -0.23 45280.0 -99800.0 -0.83 -0.7448 -0.8695 1078453 SPBio_003117 Fc1ccc(cc1)C(=O)CCCN2CCN(CC2)c3ccccn3 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P16 mock treatment 266800.0 103000.0 0.87 51160.0 -93900.0 -0.78 0.0687 0.0587 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P17 compound treatment 228120.0 64000.0 0.54 60680.0 -84400.0 -0.7 -0.1085 -0.1225 3188288 SPBio_003118 CO/N=C(/C(=O)N[C@H]1[C@H]2SCC(=C(N2C1=O)C(=O)O)C[N+]3(C)CCCC3)\c4csc(N)n4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P18 mock treatment 260280.0 96200.0 0.82 36920.0 -108000.0 -0.89 -0.0539 -0.0444 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P19 compound treatment 192720.0 28600.0 0.24 26440.0 -119000.0 -0.98 -0.5219 -0.516 3188289 SPBio_003119 C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@H]1C(=O)COC(=O)C(C)(C)C 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P20 mock treatment 169640.0 5520.0 0.05 46280.0 -98800.0 -0.82 -0.5448 -0.6653 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P21 compound treatment 126040.0 -38100.0 -0.32 82600.0 -62500.0 -0.52 -0.5948 -0.9747 2884 SPBio_003120 CC1(C)S[C@@H]2[C@H](NC(=O)C3(N)CCCCC3)C(=O)N2[C@H]1C(=O)O 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P22 mock treatment 91640.0 -72500.0 -0.62 85200.0 -59900.0 -0.5 -0.7867 -0.9941 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P23 mock treatment 87640.0 -76500.0 -0.65 88720.0 -56400.0 -0.47 -0.7902 -0.9866 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.2167 P24 mock treatment 47400.0 -117000.0 -0.99 40840.0 -104000.0 -0.86 -1.3126 -0.9975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A01 mock treatment 109400.0 -109000.0 -0.93 86880.0 -130000.0 -1.08 -1.4193 -0.9972 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A02 mock treatment 144600.0 -73900.0 -0.63 127920.0 -89300.0 -0.74 -0.9674 -0.9968 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A03 mock treatment 135720.0 -82800.0 -0.7 179080.0 -38100.0 -0.32 -0.7215 -0.9343 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A04 mock treatment 125360.0 -93100.0 -0.79 217840.0 611.0 0.01 -0.5572 -0.7026 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A05 mock treatment 82200.0 -136000.0 -1.16 251120.0 33900.0 0.28 -0.6224 -0.5213 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A06 mock treatment 87760.0 -131000.0 -1.11 276960.0 59700.0 0.49 -0.4377 -0.3594 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A07 mock treatment 41760.0 -177000.0 -1.5 275960.0 58700.0 0.49 -0.7205 -0.4556 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A08 mock treatment 77800.0 -141000.0 -1.2 280520.0 63300.0 0.52 -0.4769 -0.3647 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A09 mock treatment 71440.0 -147000.0 -1.25 263600.0 46400.0 0.38 -0.6141 -0.469 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A10 mock treatment 54360.0 -164000.0 -1.4 266480.0 49300.0 0.41 -0.7001 -0.4809 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A11 mock treatment 118440.0 -100000.0 -0.85 288520.0 71300.0 0.59 -0.1854 -0.1789 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A12 mock treatment 213200.0 -5300.0 -0.05 272160.0 54900.0 0.45 0.2894 0.6337 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A13 mock treatment 210640.0 -7860.0 -0.07 302640.0 85400.0 0.71 0.4523 0.6373 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A14 mock treatment 134720.0 -83800.0 -0.71 292640.0 75400.0 0.62 -0.0633 -0.0668 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A15 mock treatment 86120.0 -132000.0 -1.13 289120.0 71900.0 0.59 -0.3765 -0.2954 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A16 mock treatment 98560.0 -120000.0 -1.02 313200.0 96000.0 0.79 -0.1607 -0.1242 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A17 mock treatment 81720.0 -137000.0 -1.16 274480.0 57300.0 0.47 -0.4886 -0.3886 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A18 mock treatment 82960.0 -136000.0 -1.15 274440.0 57200.0 0.47 -0.4814 -0.3859 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A19 mock treatment 119000.0 -99500.0 -0.85 262000.0 44800.0 0.37 -0.3372 -0.3646 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A20 mock treatment 134440.0 -84100.0 -0.72 226920.0 9690.0 0.08 -0.4494 -0.624 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A21 mock treatment 122720.0 -95800.0 -0.82 194160.0 -23100.0 -0.19 -0.7116 -0.8496 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A22 mock treatment 139680.0 -78800.0 -0.67 159560.0 -57700.0 -0.48 -0.8119 -0.986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A23 mock treatment 123280.0 -95200.0 -0.81 107200.0 -110000.0 -0.91 -1.2169 -0.9983 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base A24 mock treatment 158320.0 -60200.0 -0.51 52440.0 -165000.0 -1.36 -1.3263 -0.9107 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B01 mock treatment 135480.0 -83000.0 -0.71 164440.0 -52800.0 -0.44 -0.8086 -0.9732 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B02 mock treatment 145640.0 -72900.0 -0.62 219040.0 1810.0 0.01 -0.4281 -0.6898 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B03 mock treatment 148720.0 -69800.0 -0.59 235720.0 18500.0 0.15 -0.312 -0.5085 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B04 mock treatment 117040.0 -101000.0 -0.86 241560.0 24300.0 0.2 -0.4685 -0.5282 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B05 mock treatment 132400.0 -86100.0 -0.73 263840.0 46600.0 0.39 -0.2457 -0.2966 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B06 mock treatment 141480.0 -77000.0 -0.66 279680.0 62500.0 0.52 -0.0984 -0.1179 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B07 mock treatment 79840.0 -139000.0 -1.18 291920.0 74700.0 0.62 -0.3979 -0.2986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B08 mock treatment 69040.0 -149000.0 -1.27 302440.0 85200.0 0.7 -0.4014 -0.2759 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B09 mock treatment 59880.0 -159000.0 -1.35 308880.0 91700.0 0.76 -0.4189 -0.2704 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B10 mock treatment 107680.0 -111000.0 -0.94 316520.0 99300.0 0.82 -0.0864 -0.069 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B11 mock treatment 165440.0 -53100.0 -0.45 324160.0 107000.0 0.88 0.3061 0.3081 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B12 mock treatment 249600.0 31100.0 0.26 306600.0 89400.0 0.74 0.71 0.9041 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B13 mock treatment 256360.0 37900.0 0.32 297280.0 80100.0 0.66 0.6962 0.9453 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B14 mock treatment 199800.0 -18700.0 -0.16 304800.0 87600.0 0.72 0.3997 0.5388 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B15 mock treatment 109880.0 -109000.0 -0.92 280800.0 63600.0 0.53 -0.2821 -0.2651 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B16 mock treatment 97360.0 -121000.0 -1.03 300160.0 82900.0 0.69 -0.2442 -0.1971 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B17 mock treatment 73120.0 -145000.0 -1.24 273320.0 56100.0 0.46 -0.5472 -0.4139 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B18 mock treatment 70440.0 -148000.0 -1.26 283720.0 66500.0 0.55 -0.5025 -0.3653 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B19 mock treatment 115240.0 -103000.0 -0.88 279000.0 61800.0 0.51 -0.2603 -0.256 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B20 mock treatment 104400.0 -114000.0 -0.97 268360.0 51100.0 0.42 -0.3879 -0.366 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B21 mock treatment 113880.0 -105000.0 -0.89 234280.0 17100.0 0.14 -0.5301 -0.5878 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B22 mock treatment 155720.0 -62800.0 -0.53 239000.0 21800.0 0.18 -0.2506 -0.4443 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B23 mock treatment 163480.0 -55000.0 -0.47 222040.0 4810.0 0.04 -0.3031 -0.6447 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base B24 mock treatment 151360.0 -67100.0 -0.57 126400.0 -90800.0 -0.75 -0.9355 -0.9909 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C01 mock treatment 123080.0 -95400.0 -0.81 160320.0 -56900.0 -0.47 -0.9074 -0.9663 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C02 mock treatment 161560.0 -56900.0 -0.48 197400.0 -19800.0 -0.16 -0.4588 -0.8964 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C03 mock treatment 110160.0 -108000.0 -0.92 221920.0 4690.0 0.04 -0.6248 -0.6768 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C04 mock treatment 138000.0 -80500.0 -0.69 219880.0 2650.0 0.02 -0.4692 -0.6841 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C05 mock treatment 157440.0 -61100.0 -0.52 250800.0 33600.0 0.28 -0.1712 -0.2905 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C06 mock treatment 172160.0 -46300.0 -0.39 288840.0 71600.0 0.59 0.1399 0.1965 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C07 mock treatment 95200.0 -123000.0 -1.05 280000.0 62800.0 0.52 -0.3751 -0.3203 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C08 mock treatment 92320.0 -126000.0 -1.07 321040.0 104000.0 0.86 -0.1524 -0.1108 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C09 mock treatment 81440.0 -137000.0 -1.17 284040.0 66800.0 0.55 -0.4344 -0.3364 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C10 mock treatment 117480.0 -101000.0 -0.86 338600.0 121000.0 1.0 0.1018 0.077 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C11 mock treatment 172960.0 -45500.0 -0.39 324800.0 108000.0 0.89 0.3551 0.3658 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C12 mock treatment 235080.0 16600.0 0.14 333560.0 116000.0 0.96 0.7803 0.8022 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C13 mock treatment 226480.0 7980.0 0.07 295000.0 77800.0 0.64 0.503 0.7774 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C14 mock treatment 155640.0 -62900.0 -0.54 274200.0 57000.0 0.47 -0.0452 -0.0634 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C15 mock treatment 116680.0 -102000.0 -0.87 320640.0 103000.0 0.86 -0.0081 -0.0066 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C16 mock treatment 91520.0 -127000.0 -1.08 261920.0 44700.0 0.37 -0.5031 -0.4403 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C17 mock treatment 87840.0 -131000.0 -1.11 286200.0 69000.0 0.57 -0.3832 -0.3065 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C18 mock treatment 102320.0 -116000.0 -0.99 266120.0 48900.0 0.4 -0.4135 -0.3869 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C19 mock treatment 128720.0 -89800.0 -0.76 259520.0 42300.0 0.35 -0.2931 -0.3487 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C20 mock treatment 120000.0 -98500.0 -0.84 241480.0 24300.0 0.2 -0.4512 -0.5232 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C21 mock treatment 108360.0 -110000.0 -0.94 246320.0 29100.0 0.24 -0.4929 -0.5091 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C22 mock treatment 90320.0 -128000.0 -1.09 206720.0 -10500.0 -0.09 -0.8332 -0.761 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C23 mock treatment 133320.0 -85200.0 -0.73 180600.0 -36600.0 -0.3 -0.7271 -0.925 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base C24 mock treatment 133000.0 -85500.0 -0.73 111080.0 -106000.0 -0.88 -1.1357 -0.9957 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D01 mock treatment 80440.0 -138000.0 -1.18 142280.0 -74900.0 -0.62 -1.2696 -0.9553 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D02 mock treatment 107520.0 -111000.0 -0.94 181840.0 -35400.0 -0.29 -0.8752 -0.8847 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D03 mock treatment 138640.0 -79900.0 -0.68 207200.0 -10000.0 -0.08 -0.5395 -0.7875 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D04 mock treatment 165920.0 -52600.0 -0.45 230240.0 13000.0 0.11 -0.2405 -0.5222 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D05 mock treatment 201320.0 -17200.0 -0.15 265280.0 48100.0 0.4 0.1776 0.4194 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D06 mock treatment 190400.0 -28100.0 -0.24 280760.0 63500.0 0.53 0.2024 0.3506 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D07 mock treatment 127200.0 -91300.0 -0.78 287600.0 70400.0 0.58 -0.138 -0.1421 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D08 mock treatment 139120.0 -79400.0 -0.68 288480.0 71300.0 0.59 -0.0611 -0.0682 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D09 mock treatment 154240.0 -64300.0 -0.55 327560.0 110000.0 0.91 0.2585 0.2429 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D10 mock treatment 132920.0 -85600.0 -0.73 305040.0 87800.0 0.73 -0.0016 -0.0015 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D11 mock treatment 204240.0 -14300.0 -0.12 315160.0 97900.0 0.81 0.487 0.5945 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D12 mock treatment 251520.0 33000.0 0.28 293520.0 76300.0 0.63 0.6451 0.9336 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D13 mock treatment 253080.0 34600.0 0.29 309520.0 92300.0 0.76 0.7481 0.9142 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D14 mock treatment 195960.0 -22500.0 -0.19 285200.0 68000.0 0.56 0.2619 0.4408 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D15 mock treatment 134000.0 -84500.0 -0.72 315720.0 98500.0 0.81 0.0674 0.062 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D16 mock treatment 119640.0 -98900.0 -0.84 295040.0 77800.0 0.64 -0.14 -0.1321 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D17 mock treatment 126480.0 -92000.0 -0.78 273480.0 56300.0 0.47 -0.225 -0.2469 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D18 mock treatment 140960.0 -77500.0 -0.66 281000.0 63800.0 0.53 -0.0938 -0.111 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D19 mock treatment 146600.0 -71900.0 -0.61 275040.0 57800.0 0.48 -0.0947 -0.1219 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D20 mock treatment 172760.0 -45700.0 -0.39 265640.0 48400.0 0.4 0.0078 0.014 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D21 mock treatment 128400.0 -90100.0 -0.77 244920.0 27700.0 0.23 -0.3805 -0.4752 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D22 mock treatment 122000.0 -96500.0 -0.82 213080.0 -4150.0 -0.03 -0.6053 -0.736 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D23 mock treatment 105680.0 -113000.0 -0.96 194240.0 -23000.0 -0.19 -0.8137 -0.831 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base D24 mock treatment 142920.0 -75600.0 -0.64 122440.0 -94800.0 -0.78 -1.0095 -0.9952 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E01 mock treatment 57080.0 -161000.0 -1.37 190320.0 -26900.0 -0.22 -1.1293 -0.8111 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E02 mock treatment 102760.0 -116000.0 -0.99 194200.0 -23000.0 -0.19 -0.8315 -0.8285 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E03 mock treatment 136800.0 -81700.0 -0.7 214200.0 -3030.0 -0.03 -0.5096 -0.7321 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E04 mock treatment 190040.0 -28500.0 -0.24 247680.0 30500.0 0.25 0.0068 0.0194 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E05 mock treatment 204360.0 -14100.0 -0.12 274920.0 57700.0 0.48 0.2523 0.5126 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E06 mock treatment 233040.0 14500.0 0.12 267840.0 50600.0 0.42 0.3836 0.8786 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E07 mock treatment 171320.0 -47200.0 -0.4 281360.0 64100.0 0.53 0.0911 0.1369 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E08 mock treatment 159400.0 -59100.0 -0.5 298400.0 81200.0 0.67 0.119 0.1418 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E09 mock treatment 192760.0 -25700.0 -0.22 303960.0 86700.0 0.72 0.3524 0.4697 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E10 mock treatment 190480.0 -28000.0 -0.24 325040.0 108000.0 0.89 0.462 0.5004 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E11 mock treatment 224480.0 5980.0 0.05 304040.0 86800.0 0.72 0.5438 0.7553 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E12 mock treatment 259800.0 41300.0 0.35 471360.0 254000.0 2.1 1.7352 0.8141 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E13 mock treatment 263760.0 45300.0 0.39 308120.0 90900.0 0.75 0.8042 0.9518 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E14 mock treatment 227640.0 9140.0 0.08 306280.0 89100.0 0.74 0.5759 0.7775 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E15 mock treatment 197360.0 -21100.0 -0.18 293880.0 76700.0 0.63 0.3211 0.4871 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E16 mock treatment 138640.0 -79900.0 -0.68 286720.0 69500.0 0.57 -0.0743 -0.0835 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E17 mock treatment 186120.0 -32400.0 -0.28 308320.0 91100.0 0.75 0.3379 0.4211 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E18 mock treatment 172520.0 -46000.0 -0.39 268560.0 51300.0 0.42 0.0234 0.0406 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E19 mock treatment 212280.0 -6220.0 -0.05 269520.0 52300.0 0.43 0.2684 0.6159 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E20 mock treatment 204880.0 -13600.0 -0.12 327960.0 111000.0 0.92 0.5657 0.6127 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E21 mock treatment 159560.0 -58900.0 -0.5 251080.0 33900.0 0.28 -0.1568 -0.2729 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E22 mock treatment 140240.0 -78300.0 -0.67 225400.0 8170.0 0.07 -0.4234 -0.6321 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E23 mock treatment 137840.0 -80700.0 -0.69 201920.0 -15300.0 -0.13 -0.5752 -0.8236 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base E24 mock treatment 78560.0 -140000.0 -1.19 110160.0 -107000.0 -0.89 -1.4688 -0.9893 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F01 mock treatment 55880.0 -163000.0 -1.38 192040.0 -25200.0 -0.21 -1.1264 -0.8045 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F02 mock treatment 97480.0 -121000.0 -1.03 172520.0 -44700.0 -0.37 -0.9901 -0.9044 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F03 mock treatment 121880.0 -96600.0 -0.82 224280.0 7050.0 0.06 -0.5405 -0.6553 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F04 mock treatment 188800.0 -29700.0 -0.25 247920.0 30700.0 0.25 7.0E-4 0.002 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F05 mock treatment 239440.0 20900.0 0.18 291440.0 74200.0 0.61 0.5602 0.8762 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F06 mock treatment 238120.0 19600.0 0.17 273240.0 56000.0 0.46 0.4458 0.905 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F07 mock treatment 215440.0 -3060.0 -0.03 272360.0 55100.0 0.46 0.3041 0.6656 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F08 mock treatment 230200.0 11700.0 0.1 308120.0 90900.0 0.75 0.6021 0.7938 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F09 mock treatment 238240.0 19700.0 0.17 297360.0 80100.0 0.66 0.5876 0.8592 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F10 mock treatment 225720.0 7220.0 0.06 299640.0 82400.0 0.68 0.5255 0.7677 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F11 mock treatment 250400.0 31900.0 0.27 315240.0 98000.0 0.81 0.7654 0.8951 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F12 mock treatment 282920.0 64400.0 0.55 335360.0 118000.0 0.98 1.0789 0.9627 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F13 mock treatment 263480.0 45000.0 0.38 290840.0 73600.0 0.61 0.7014 0.975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F14 mock treatment 223040.0 4540.0 0.04 300760.0 83500.0 0.69 0.516 0.7455 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F15 mock treatment 224880.0 6380.0 0.05 286440.0 69200.0 0.57 0.4433 0.7707 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F16 mock treatment 217120.0 -1380.0 -0.01 269440.0 52200.0 0.43 0.2971 0.6876 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F17 mock treatment 223480.0 4980.0 0.04 308000.0 90800.0 0.75 0.561 0.7458 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F18 mock treatment 216560.0 -1940.0 -0.02 295320.0 78100.0 0.65 0.4451 0.6888 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F19 mock treatment 232360.0 13900.0 0.12 268720.0 51500.0 0.43 0.3846 0.8702 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F20 mock treatment 215960.0 -2540.0 -0.02 263320.0 46100.0 0.38 0.2543 0.6659 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F21 mock treatment 204800.0 -13700.0 -0.12 253040.0 35800.0 0.3 0.127 0.3988 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F22 mock treatment 165280.0 -53200.0 -0.45 227000.0 9770.0 0.08 -0.2633 -0.5719 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F23 mock treatment 122720.0 -95800.0 -0.82 216800.0 -429.0 0.0 -0.5792 -0.7102 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base F24 mock treatment 80400.0 -138000.0 -1.18 79080.0 -138000.0 -1.14 -1.6396 -0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G01 mock treatment 113480.0 -105000.0 -0.89 141280.0 -75900.0 -0.63 -1.0766 -0.9851 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G02 mock treatment 92160.0 -126000.0 -1.08 201320.0 -15900.0 -0.13 -0.8537 -0.7877 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G03 mock treatment 165920.0 -52600.0 -0.45 204520.0 -12700.0 -0.11 -0.3909 -0.85 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G04 mock treatment 213040.0 -5460.0 -0.05 260920.0 43700.0 0.36 0.2227 0.6111 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G05 mock treatment 238760.0 20300.0 0.17 270040.0 52800.0 0.44 0.4309 0.9174 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G06 mock treatment 227120.0 8620.0 0.07 280360.0 63100.0 0.52 0.4212 0.7986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G07 mock treatment 233440.0 14900.0 0.13 264880.0 47700.0 0.39 0.3687 0.8901 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G08 mock treatment 231520.0 13000.0 0.11 287240.0 70000.0 0.58 0.4879 0.8274 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G09 mock treatment 247360.0 28900.0 0.25 306120.0 88900.0 0.74 0.6937 0.8947 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G10 mock treatment 264360.0 45900.0 0.39 316040.0 98800.0 0.82 0.8541 0.9428 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G11 mock treatment 265560.0 47100.0 0.4 296080.0 78900.0 0.65 0.7446 0.9726 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G12 mock treatment 280520.0 62000.0 0.53 326920.0 110000.0 0.91 1.015 0.9668 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G13 mock treatment 293120.0 74600.0 0.64 300680.0 83500.0 0.69 0.9374 0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G14 mock treatment 250120.0 31600.0 0.27 277360.0 60100.0 0.5 0.5421 0.9584 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G15 mock treatment 239400.0 20900.0 0.18 253080.0 35900.0 0.3 0.3355 0.9701 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G16 mock treatment 230600.0 12100.0 0.1 254880.0 37700.0 0.31 0.2931 0.8934 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G17 mock treatment 225680.0 7180.0 0.06 277000.0 59800.0 0.49 0.3929 0.7885 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G18 mock treatment 213960.0 -4540.0 -0.04 271120.0 53900.0 0.45 0.2879 0.6434 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G19 mock treatment 243560.0 25100.0 0.21 279560.0 62300.0 0.52 0.5155 0.9237 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G20 mock treatment 215960.0 -2540.0 -0.02 283440.0 66200.0 0.55 0.372 0.6786 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G21 mock treatment 197680.0 -20800.0 -0.18 232560.0 15300.0 0.13 -0.0357 -0.1637 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G22 mock treatment 208960.0 -9540.0 -0.08 222320.0 5090.0 0.04 -0.0277 -0.3023 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G23 mock treatment 145880.0 -72600.0 -0.62 220120.0 2890.0 0.02 -0.4203 -0.6792 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base G24 mock treatment 111280.0 -107000.0 -0.91 57280.0 -160000.0 -1.32 -1.5812 -0.9836 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H01 mock treatment 93640.0 -125000.0 -1.06 92640.0 -125000.0 -1.03 -1.4805 -0.9999 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H02 mock treatment 135200.0 -83300.0 -0.71 134760.0 -82500.0 -0.68 -0.9839 -0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H03 mock treatment 183200.0 -35300.0 -0.3 216800.0 -429.0 0.0 -0.215 -0.7154 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H04 mock treatment 214080.0 -4420.0 -0.04 233040.0 15800.0 0.13 0.0659 0.4839 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H05 mock treatment 236400.0 17900.0 0.15 265200.0 48000.0 0.4 0.3884 0.9136 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H06 mock treatment 241760.0 23300.0 0.2 270880.0 53700.0 0.44 0.4539 0.9339 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H07 mock treatment 245120.0 26600.0 0.23 279760.0 62500.0 0.52 0.526 0.9314 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H08 mock treatment 242520.0 24000.0 0.2 288560.0 71300.0 0.59 0.5619 0.8997 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H09 mock treatment 264120.0 45600.0 0.39 278160.0 60900.0 0.5 0.6311 0.9917 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H10 mock treatment 280160.0 61700.0 0.52 301880.0 84700.0 0.7 0.8664 0.9899 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H11 mock treatment 291920.0 73400.0 0.63 283200.0 66000.0 0.55 0.8279 0.9977 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H12 mock treatment 352160.0 134000.0 1.14 292440.0 75200.0 0.62 1.2447 0.9596 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H13 mock treatment 301120.0 82600.0 0.7 315160.0 97900.0 0.81 1.0703 0.9975 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H14 mock treatment 284240.0 65700.0 0.56 276400.0 59200.0 0.49 0.7419 0.9978 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H15 mock treatment 275400.0 56900.0 0.48 262280.0 45100.0 0.37 0.6061 0.9916 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H16 mock treatment 239560.0 21100.0 0.18 237320.0 20100.0 0.17 0.2443 0.9993 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H17 mock treatment 249960.0 31500.0 0.27 248240.0 31000.0 0.26 0.3708 0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H18 mock treatment 244000.0 25500.0 0.22 256000.0 38800.0 0.32 0.3803 0.9819 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H19 mock treatment 248960.0 30500.0 0.26 257360.0 40100.0 0.33 0.4181 0.9925 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H20 mock treatment 249880.0 31400.0 0.27 242920.0 25700.0 0.21 0.3392 0.9936 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H21 mock treatment 225920.0 7420.0 0.06 238600.0 21400.0 0.18 0.1697 0.9038 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H22 mock treatment 204480.0 -14000.0 -0.12 234280.0 17100.0 0.14 0.0153 0.0829 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H23 mock treatment 184160.0 -34300.0 -0.29 181640.0 -35600.0 -0.29 -0.4149 -1.0 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base H24 mock treatment 112640.0 -106000.0 -0.9 62240.0 -155000.0 -1.28 -1.544 -0.9851 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I01 mock treatment 143000.0 -75500.0 -0.64 60440.0 -157000.0 -1.3 -1.3717 -0.9476 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I02 mock treatment 183160.0 -35300.0 -0.3 171800.0 -45400.0 -0.38 -0.4785 -0.9939 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I03 mock treatment 209320.0 -9180.0 -0.08 181600.0 -35600.0 -0.29 -0.2637 -0.8648 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I04 mock treatment 246840.0 28300.0 0.24 226880.0 9650.0 0.08 0.2271 0.8934 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I05 mock treatment 266160.0 47700.0 0.41 280120.0 62900.0 0.52 0.6548 0.9924 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I06 mock treatment 240640.0 22100.0 0.19 250280.0 33100.0 0.27 0.3266 0.9835 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I07 mock treatment 278200.0 59700.0 0.51 262160.0 44900.0 0.37 0.6222 0.9882 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I08 mock treatment 272440.0 53900.0 0.46 246520.0 29300.0 0.24 0.4961 0.9554 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I09 mock treatment 284800.0 66300.0 0.56 261880.0 44700.0 0.37 0.6603 0.9789 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I10 mock treatment 311320.0 92800.0 0.79 256560.0 39300.0 0.33 0.7889 0.9231 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I11 mock treatment 282040.0 63500.0 0.54 277400.0 60200.0 0.5 0.7345 0.9991 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I12 mock treatment 294920.0 76400.0 0.65 300080.0 82900.0 0.69 0.9447 0.9997 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I13 mock treatment 272360.0 53900.0 0.46 267200.0 50000.0 0.41 0.6166 0.9987 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I14 mock treatment 311440.0 92900.0 0.79 255880.0 38700.0 0.32 0.7856 0.9205 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I15 mock treatment 252240.0 33700.0 0.29 219000.0 1770.0 0.01 0.2135 0.7422 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I16 mock treatment 257040.0 38500.0 0.33 219360.0 2130.0 0.02 0.2445 0.744 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I17 mock treatment 271120.0 52600.0 0.45 231880.0 14700.0 0.12 0.4025 0.8672 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I18 mock treatment 264800.0 46300.0 0.39 243840.0 26600.0 0.22 0.4344 0.9621 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I19 mock treatment 259960.0 41500.0 0.35 307760.0 90500.0 0.75 0.7792 0.9411 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I20 mock treatment 233160.0 14700.0 0.12 265920.0 48700.0 0.4 0.3731 0.8847 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I21 mock treatment 220440.0 1940.0 0.02 244240.0 27000.0 0.22 0.1697 0.7573 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I22 mock treatment 195840.0 -22700.0 -0.19 196040.0 -21200.0 -0.18 -0.2604 -0.9989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I23 mock treatment 171560.0 -46900.0 -0.4 202360.0 -14900.0 -0.12 -0.3696 -0.8838 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base I24 mock treatment 148240.0 -70300.0 -0.6 38800.0 -178000.0 -1.48 -1.4668 -0.9209 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J01 mock treatment 160560.0 -57900.0 -0.49 74840.0 -142000.0 -1.18 -1.1818 -0.9254 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J02 mock treatment 189280.0 -29200.0 -0.25 139040.0 -78200.0 -0.65 -0.6333 -0.9138 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J03 mock treatment 243640.0 25100.0 0.21 218560.0 1330.0 0.01 0.1591 0.7425 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J04 mock treatment 244400.0 25900.0 0.22 238080.0 20900.0 0.17 0.2779 0.9926 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J05 mock treatment 264760.0 46300.0 0.39 267960.0 50700.0 0.42 0.5753 0.9995 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J06 mock treatment 250320.0 31800.0 0.27 261360.0 44100.0 0.37 0.4497 0.9892 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J07 mock treatment 263000.0 44500.0 0.38 239280.0 22100.0 0.18 0.3969 0.9439 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J08 mock treatment 263080.0 44600.0 0.38 254840.0 37600.0 0.31 0.4884 0.9951 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J09 mock treatment 270040.0 51500.0 0.44 256320.0 39100.0 0.32 0.539 0.9887 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J10 mock treatment 276760.0 58300.0 0.5 281560.0 64300.0 0.53 0.7271 0.9994 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J11 mock treatment 324600.0 106000.0 0.9 291480.0 74300.0 0.61 1.0731 0.9823 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J12 mock treatment 298080.0 79600.0 0.68 279520.0 62300.0 0.52 0.8435 0.9909 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J13 mock treatment 296120.0 77600.0 0.66 305080.0 87900.0 0.73 0.9812 0.9989 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J14 mock treatment 293840.0 75300.0 0.64 250640.0 33400.0 0.28 0.649 0.9292 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J15 mock treatment 277440.0 58900.0 0.5 213800.0 -3430.0 -0.03 0.3348 0.6661 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J16 mock treatment 263800.0 45300.0 0.39 216320.0 -909.0 -0.01 0.2674 0.6932 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J17 mock treatment 273600.0 55100.0 0.47 301440.0 84200.0 0.7 0.8243 0.9815 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J18 mock treatment 254200.0 35700.0 0.3 239840.0 22600.0 0.19 0.3472 0.9728 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J19 mock treatment 273280.0 54800.0 0.47 271520.0 54300.0 0.45 0.6474 0.9998 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J20 mock treatment 256440.0 37900.0 0.32 306640.0 89400.0 0.74 0.7514 0.931 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J21 mock treatment 228720.0 10200.0 0.09 220920.0 3690.0 0.03 0.0831 0.9014 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J22 mock treatment 221920.0 3420.0 0.03 206320.0 -10900.0 -0.09 -0.0432 -0.456 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J23 mock treatment 192960.0 -25500.0 -0.22 181120.0 -36100.0 -0.3 -0.365 -0.9878 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base J24 mock treatment 181040.0 -37500.0 -0.32 58440.0 -159000.0 -1.31 -1.1544 -0.854 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K01 mock treatment 243920.0 25400.0 0.22 43760.0 -173000.0 -1.44 -0.8617 -0.5938 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K02 mock treatment 217640.0 -862.0 -0.01 165280.0 -51900.0 -0.43 -0.3091 -0.7191 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K03 mock treatment 187600.0 -30900.0 -0.26 175880.0 -41300.0 -0.34 -0.4279 -0.9916 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K04 mock treatment 235760.0 17300.0 0.15 214200.0 -3030.0 -0.03 0.0862 0.5782 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K05 mock treatment 251200.0 32700.0 0.28 235760.0 18500.0 0.15 0.3053 0.9605 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K06 mock treatment 352200.0 134000.0 1.14 241160.0 23900.0 0.2 0.9449 0.8178 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K07 mock treatment 301480.0 83000.0 0.71 227000.0 9770.0 0.08 0.5567 0.7829 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K08 mock treatment 256560.0 38100.0 0.32 236200.0 19000.0 0.16 0.3401 0.9446 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K09 mock treatment 286920.0 68400.0 0.58 240120.0 22900.0 0.19 0.5458 0.8911 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K10 mock treatment 349720.0 131000.0 1.12 298400.0 81200.0 0.67 1.2648 0.9703 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K11 mock treatment 302240.0 83700.0 0.71 236520.0 19300.0 0.16 0.617 0.8445 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K12 mock treatment 280000.0 61500.0 0.52 276680.0 59500.0 0.49 0.718 0.9995 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K13 mock treatment 453440.0 235000.0 2.0 286600.0 69400.0 0.57 1.8202 0.8747 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K14 mock treatment 301800.0 83300.0 0.71 230080.0 12900.0 0.11 0.5767 0.8041 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K15 mock treatment 310400.0 91900.0 0.78 193760.0 -23500.0 -0.19 0.416 0.516 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K16 mock treatment 297960.0 79500.0 0.68 159840.0 -57400.0 -0.47 0.1427 0.1726 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K17 mock treatment 274320.0 55800.0 0.48 186040.0 -31200.0 -0.26 0.1536 0.2841 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K18 mock treatment 282040.0 63500.0 0.54 275080.0 57900.0 0.48 0.7209 0.9981 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K19 mock treatment 310840.0 92300.0 0.79 244560.0 27300.0 0.23 0.7158 0.875 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K20 mock treatment 254840.0 36300.0 0.31 229920.0 12700.0 0.1 0.293 0.8968 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K21 mock treatment 234240.0 15700.0 0.13 175160.0 -42100.0 -0.35 -0.1513 -0.4058 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K22 mock treatment 209600.0 -8900.0 -0.08 120320.0 -96900.0 -0.8 -0.6205 -0.7705 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K23 mock treatment 173160.0 -45300.0 -0.39 181760.0 -35500.0 -0.29 -0.4805 -0.9908 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base K24 mock treatment 214720.0 -3780.0 -0.03 50040.0 -167000.0 -1.38 -1.0008 -0.7234 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L01 mock treatment 217920.0 -582.0 0.0 46920.0 -170000.0 -1.41 -0.9998 -0.7096 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L02 mock treatment 220760.0 2260.0 0.02 110320.0 -107000.0 -0.88 -0.6118 -0.6916 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L03 mock treatment 193880.0 -24600.0 -0.21 125000.0 -92200.0 -0.76 -0.6877 -0.8692 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L04 mock treatment 222560.0 4060.0 0.03 175480.0 -41700.0 -0.35 -0.2198 -0.6332 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L05 mock treatment 263800.0 45300.0 0.39 193560.0 -23700.0 -0.2 0.1343 0.3104 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L06 mock treatment 277440.0 58900.0 0.5 228840.0 11600.0 0.1 0.4228 0.8274 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L07 mock treatment 284160.0 65700.0 0.56 255240.0 38000.0 0.31 0.6176 0.963 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L08 mock treatment 287200.0 68700.0 0.58 211920.0 -5310.0 -0.04 0.3825 0.6522 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L09 mock treatment 266160.0 47700.0 0.41 238600.0 21400.0 0.18 0.4119 0.9307 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L10 mock treatment 278640.0 60100.0 0.51 228440.0 11200.0 0.09 0.4276 0.8218 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L11 mock treatment 305240.0 86700.0 0.74 244560.0 27300.0 0.23 0.6821 0.8831 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L12 mock treatment 338080.0 120000.0 1.02 265520.0 48300.0 0.4 1.0024 0.9165 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L13 mock treatment 276920.0 58400.0 0.5 264360.0 47100.0 0.39 0.6274 0.9927 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L14 mock treatment 355560.0 137000.0 1.17 182280.0 -34900.0 -0.29 0.6207 0.5163 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L15 mock treatment 295360.0 76900.0 0.65 183080.0 -34100.0 -0.28 0.263 0.3689 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L16 mock treatment 346480.0 128000.0 1.09 152200.0 -65000.0 -0.54 0.3901 0.321 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L17 mock treatment 281760.0 63300.0 0.54 172400.0 -44800.0 -0.37 0.1186 0.1814 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L18 mock treatment 270640.0 52100.0 0.44 179440.0 -37800.0 -0.31 0.0928 0.171 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L19 mock treatment 256920.0 38400.0 0.33 217040.0 -189.0 0.0 0.2302 0.7037 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L20 mock treatment 274120.0 55600.0 0.47 183480.0 -33700.0 -0.28 0.1374 0.25 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L21 mock treatment 230400.0 11900.0 0.1 177960.0 -39300.0 -0.32 -0.1581 -0.4645 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L22 mock treatment 217480.0 -1020.0 -0.01 103720.0 -114000.0 -0.94 -0.6701 -0.7136 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L23 mock treatment 205560.0 -12900.0 -0.11 127880.0 -89300.0 -0.74 -0.6006 -0.8036 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base L24 mock treatment 225360.0 6860.0 0.06 65600.0 -152000.0 -1.25 -0.8457 -0.6735 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M01 mock treatment 202240.0 -16300.0 -0.14 70360.0 -147000.0 -1.22 -0.957 -0.7826 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M02 mock treatment 205840.0 -12700.0 -0.11 128160.0 -89100.0 -0.74 -0.5973 -0.802 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M03 mock treatment 223960.0 5460.0 0.05 103680.0 -114000.0 -0.94 -0.6314 -0.6713 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M04 mock treatment 233720.0 15200.0 0.13 127680.0 -89500.0 -0.74 -0.4322 -0.5747 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M05 mock treatment 269400.0 50900.0 0.43 167040.0 -50200.0 -0.42 0.0128 0.0214 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M06 mock treatment 296960.0 78500.0 0.67 179080.0 -38100.0 -0.32 0.2492 0.3373 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M07 mock treatment 301080.0 82600.0 0.7 156920.0 -60300.0 -0.5 0.1444 0.1675 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M08 mock treatment 268840.0 50300.0 0.43 127200.0 -90000.0 -0.74 -0.2236 -0.2602 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M09 mock treatment 310280.0 91800.0 0.78 191320.0 -25900.0 -0.21 0.401 0.4949 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M10 mock treatment 294040.0 75500.0 0.64 180760.0 -36500.0 -0.3 0.2414 0.3399 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M11 mock treatment 269960.0 51500.0 0.44 214560.0 -2670.0 -0.02 0.2942 0.6706 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M12 mock treatment 280480.0 62000.0 0.53 253360.0 36100.0 0.3 0.5845 0.9638 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M13 mock treatment 291360.0 72900.0 0.62 260920.0 43700.0 0.36 0.6942 0.9669 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M14 mock treatment 314360.0 95900.0 0.82 193280.0 -23900.0 -0.2 0.437 0.5203 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M15 mock treatment 322640.0 104000.0 0.89 120440.0 -96800.0 -0.8 0.0608 0.0509 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M16 mock treatment 297760.0 79300.0 0.67 134120.0 -83100.0 -0.69 -0.009 -0.0093 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M17 mock treatment 292560.0 74100.0 0.63 114280.0 -103000.0 -0.85 -0.1564 -0.1475 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M18 mock treatment 285000.0 66500.0 0.57 146240.0 -71000.0 -0.59 -0.0149 -0.0183 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M19 mock treatment 290520.0 72000.0 0.61 179160.0 -38100.0 -0.31 0.2109 0.3059 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M20 mock treatment 260760.0 42300.0 0.36 146480.0 -70700.0 -0.59 -0.1594 -0.2321 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M21 mock treatment 271520.0 53000.0 0.45 139440.0 -77800.0 -0.64 -0.1358 -0.1728 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M22 mock treatment 214080.0 -4420.0 -0.04 100680.0 -117000.0 -0.96 -0.7084 -0.7342 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M23 mock treatment 199200.0 -19300.0 -0.16 105440.0 -112000.0 -0.92 -0.7701 -0.8199 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base M24 mock treatment 214600.0 -3900.0 -0.03 49560.0 -168000.0 -1.39 -1.0043 -0.7238 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N01 mock treatment 166640.0 -51900.0 -0.44 97160.0 -120000.0 -0.99 -1.0146 -0.9334 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N02 mock treatment 229200.0 10700.0 0.09 130520.0 -86700.0 -0.72 -0.4428 -0.6124 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N03 mock treatment 237240.0 18700.0 0.16 88040.0 -129000.0 -1.07 -0.6429 -0.595 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N04 mock treatment 243720.0 25200.0 0.21 108560.0 -109000.0 -0.9 -0.4839 -0.5235 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N05 mock treatment 256360.0 37900.0 0.32 114080.0 -103000.0 -0.85 -0.3755 -0.4116 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N06 mock treatment 276880.0 58400.0 0.5 121600.0 -95600.0 -0.79 -0.2079 -0.2226 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N07 mock treatment 277720.0 59200.0 0.5 107720.0 -110000.0 -0.91 -0.2841 -0.274 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N08 mock treatment 284600.0 66100.0 0.56 121640.0 -95600.0 -0.79 -0.1612 -0.1661 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N09 mock treatment 299520.0 81000.0 0.69 133080.0 -84100.0 -0.7 -0.0045 -0.0046 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N10 mock treatment 274160.0 55700.0 0.47 148360.0 -68900.0 -0.57 -0.0678 -0.0915 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N11 mock treatment 272720.0 54200.0 0.46 153760.0 -63500.0 -0.53 -0.0449 -0.0642 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N12 mock treatment 294640.0 76100.0 0.65 237800.0 20600.0 0.17 0.5787 0.8635 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N13 mock treatment 309560.0 91100.0 0.78 239720.0 22500.0 0.19 0.6798 0.8526 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N14 mock treatment 285280.0 66800.0 0.57 164760.0 -52500.0 -0.43 0.0951 0.133 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N15 mock treatment 269880.0 51400.0 0.44 114480.0 -103000.0 -0.85 -0.2917 -0.3052 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N16 mock treatment 269480.0 51000.0 0.43 77400.0 -140000.0 -1.16 -0.511 -0.4136 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N17 mock treatment 284160.0 65700.0 0.56 74600.0 -143000.0 -1.18 -0.439 -0.3363 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N18 mock treatment 283920.0 65400.0 0.56 68800.0 -148000.0 -1.23 -0.4744 -0.3519 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N19 mock treatment 267480.0 49000.0 0.42 120920.0 -96300.0 -0.8 -0.2685 -0.2986 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N20 mock treatment 276320.0 57800.0 0.49 121280.0 -95900.0 -0.79 -0.2132 -0.2282 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N21 mock treatment 257320.0 38800.0 0.33 100480.0 -117000.0 -0.97 -0.4492 -0.4401 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N22 mock treatment 224600.0 6100.0 0.05 106320.0 -111000.0 -0.92 -0.6121 -0.666 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N23 mock treatment 206440.0 -12100.0 -0.1 79360.0 -138000.0 -1.14 -0.8791 -0.7677 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base N24 mock treatment 185840.0 -32700.0 -0.28 72240.0 -145000.0 -1.2 -1.0448 -0.8485 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O01 mock treatment 124760.0 -93700.0 -0.8 83080.0 -134000.0 -1.11 -1.3491 -0.9869 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O02 mock treatment 247960.0 29500.0 0.25 105800.0 -111000.0 -0.92 -0.4745 -0.4967 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O03 mock treatment 226040.0 7540.0 0.06 73240.0 -144000.0 -1.19 -0.7969 -0.668 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O04 mock treatment 259720.0 41200.0 0.35 86720.0 -131000.0 -1.08 -0.5153 -0.4539 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O05 mock treatment 256800.0 38300.0 0.33 73880.0 -143000.0 -1.19 -0.608 -0.4943 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O06 mock treatment 275040.0 56500.0 0.48 97760.0 -119000.0 -0.99 -0.3585 -0.3261 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O07 mock treatment 363000.0 144000.0 1.23 68320.0 -149000.0 -1.23 -0.0011 -6.0E-4 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O08 mock treatment 288880.0 70400.0 0.6 70400.0 -147000.0 -1.21 -0.4352 -0.3213 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O09 mock treatment 285400.0 66900.0 0.57 62520.0 -155000.0 -1.28 -0.5022 -0.3585 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O10 mock treatment 325680.0 107000.0 0.91 89640.0 -128000.0 -1.06 -0.1011 -0.0724 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O11 mock treatment 292920.0 74400.0 0.63 109200.0 -108000.0 -0.89 -0.1839 -0.1679 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O12 mock treatment 302320.0 83800.0 0.71 243840.0 26600.0 0.22 0.6603 0.8841 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O13 mock treatment 337000.0 118000.0 1.01 255480.0 38300.0 0.32 0.9372 0.8863 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O14 mock treatment 305480.0 87000.0 0.74 169800.0 -47400.0 -0.39 0.2462 0.2938 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O15 mock treatment 313720.0 95200.0 0.81 115040.0 -102000.0 -0.85 -0.0245 -0.0209 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O16 mock treatment 345400.0 127000.0 1.08 74880.0 -142000.0 -1.18 -0.0687 -0.043 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O17 mock treatment 313800.0 95300.0 0.81 60480.0 -157000.0 -1.3 -0.3432 -0.2244 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O18 mock treatment 306760.0 88300.0 0.75 70240.0 -147000.0 -1.22 -0.3285 -0.2298 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O19 mock treatment 294480.0 76000.0 0.65 86240.0 -131000.0 -1.08 -0.3088 -0.2447 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O20 mock treatment 306640.0 88100.0 0.75 93680.0 -124000.0 -1.02 -0.1921 -0.1515 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O21 mock treatment 270840.0 52300.0 0.45 114200.0 -103000.0 -0.85 -0.2876 -0.299 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O22 mock treatment 241480.0 23000.0 0.2 71440.0 -146000.0 -1.21 -0.7145 -0.5848 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O23 mock treatment 215360.0 -3140.0 -0.03 111640.0 -106000.0 -0.87 -0.6366 -0.7284 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base O24 mock treatment 205920.0 -12600.0 -0.11 51680.0 -166000.0 -1.37 -1.0442 -0.7601 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P01 mock treatment 50880.0 -168000.0 -1.43 96200.0 -121000.0 -1.0 -1.7172 -0.985 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P02 mock treatment 107760.0 -111000.0 -0.94 117120.0 -100000.0 -0.83 -1.2523 -0.9979 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P03 mock treatment 120960.0 -97500.0 -0.83 81360.0 -136000.0 -1.12 -1.382 -0.9889 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P04 mock treatment 199960.0 -18500.0 -0.16 67480.0 -150000.0 -1.24 -0.9876 -0.7908 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P05 mock treatment 290120.0 71600.0 0.61 47480.0 -170000.0 -1.4 -0.5618 -0.367 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P06 mock treatment 272560.0 54100.0 0.46 80560.0 -137000.0 -1.13 -0.474 -0.3883 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P07 mock treatment 329840.0 111000.0 0.95 60640.0 -157000.0 -1.3 -0.2457 -0.1531 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P08 mock treatment 316560.0 98100.0 0.83 71800.0 -145000.0 -1.2 -0.2604 -0.1778 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P09 mock treatment 311280.0 92800.0 0.79 54360.0 -163000.0 -1.35 -0.3942 -0.2524 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P10 mock treatment 345680.0 127000.0 1.08 48240.0 -169000.0 -1.4 -0.2229 -0.126 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P11 mock treatment 312200.0 93700.0 0.8 86840.0 -130000.0 -1.08 -0.1986 -0.148 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P12 mock treatment 318760.0 100000.0 0.85 185480.0 -31700.0 -0.26 0.4179 0.4679 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P13 mock treatment 330720.0 112000.0 0.96 156360.0 -60900.0 -0.5 0.3195 0.2959 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P14 mock treatment 355000.0 136000.0 1.16 94400.0 -123000.0 -1.02 0.1033 0.0669 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P15 mock treatment 342520.0 124000.0 1.06 75120.0 -142000.0 -1.18 -0.0846 -0.0536 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P16 mock treatment 334640.0 116000.0 0.99 53040.0 -164000.0 -1.36 -0.2612 -0.1555 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P17 mock treatment 359840.0 141000.0 1.2 52680.0 -165000.0 -1.36 -0.1116 -0.0614 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P18 mock treatment 322560.0 104000.0 0.89 40840.0 -176000.0 -1.46 -0.4053 -0.2374 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P19 mock treatment 287920.0 69400.0 0.59 45680.0 -172000.0 -1.42 -0.5856 -0.3809 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P20 mock treatment 245600.0 27100.0 0.23 52120.0 -165000.0 -1.37 -0.8027 -0.5795 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P21 mock treatment 194040.0 -24500.0 -0.21 80440.0 -137000.0 -1.13 -0.9474 -0.8234 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P22 mock treatment 141040.0 -77500.0 -0.66 94640.0 -123000.0 -1.01 -1.1835 -0.9783 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P23 mock treatment 115040.0 -103000.0 -0.88 70120.0 -147000.0 -1.22 -1.4834 -0.9874 1108.0001 CellTiterGlo(1108.0001) e-CadherinSyntheticLethalAssay 1108.0001.Base P24 mock treatment 52800.0 -166000.0 -1.41 69280.0 -148000.0 -1.22 -1.8631 -0.9975